LOCUS BC002427 2888 bp mRNA linear HUM 07-AUG-2008
DEFINITION Homo sapiens caspase 2, apoptosis-related cysteine peptidase, mRNA
(cDNA clone MGC:2181 IMAGE:3346279), complete cds.
ACCESSION BC002427
VERSION BC002427.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2888)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2888)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (05-FEB-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Oct 8, 2003 this sequence version replaced BC002427.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC/DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 5 Row: c Column: 12
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 39995057.
FEATURES Location/Qualifiers
source 1..2888
/db_xref="H-InvDB:HIT000030885"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:2181 IMAGE:3346279"
/tissue_type="Skin, melanotic melanoma."
/clone_lib="NIH_MGC_20"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2888
/gene="CASP2"
/gene_synonym="CASP-2"
/gene_synonym="ICH-1L"
/gene_synonym="ICH-1L/1S"
/gene_synonym="ICH1"
/db_xref="GeneID:835"
/db_xref="HGNC:HGNC:1503"
/db_xref="MIM:600639"
CDS 14..1372
/gene="CASP2"
/gene_synonym="CASP-2"
/gene_synonym="ICH-1L"
/gene_synonym="ICH-1L/1S"
/gene_synonym="ICH1"
/codon_start=1
/product="caspase 2, apoptosis-related cysteine peptidase"
/protein_id="AAH02427.2"
/db_xref="GeneID:835"
/db_xref="HGNC:HGNC:1503"
/db_xref="MIM:600639"
/translation="MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNR
VVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAF
CEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDT
VEHSLDNKDGPLCLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEF
RSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLS
HGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDG
KNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQ
VFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPGHP
PT"
BASE COUNT 665 a 744 c 679 g 800 t
ORIGIN
1 ggaaaagcgg gaaatggcgg cgccgagcgc ggggtcttgg tccaccttcc agcacaagga
61 gctgatggcc gctgacaggg gacgcaggat attgggagtg tgtggcatgc atcctcatca
121 tcaggaaact ctaaaaaaga accgagtggt gctagccaaa cagctgttgt tgagcgaatt
181 attagaacat cttctggaga aggacatcat caccttggaa atgagggagc tcatccaggc
241 caaagtgggc agtttcagcc agaatgtgga actcctcaac ttgctgccta agaggggtcc
301 ccaagctttt gatgccttct gtgaagcact gagggagacc aagcaaggcc acctggagga
361 tatgttgctc accacccttt ctgggcttca gcatgtactc ccaccgttga gctgtgacta
421 cgacttgagt ctcccttttc cggtgtgtga gtcctgtccc ctttacaaga agctccgcct
481 gtcgacagat actgtggaac actccctaga caataaagat ggtcctctct gccttcaggt
541 gaagccttgc actcctgaat tttatcaaac acacttccag ctggcatata ggttgcagtc
601 tcggcctcgt ggcctagcac tggtgttgag caatgtgcac ttcactggag agaaagaact
661 ggaatttcgc tctggagggg atgtggacca cagtactcta gtcaccctct tcaagctttt
721 gggctatgac gtccatgttc tatgtgacca gactgcacag gaaatgcaag agaaactgca
781 gaattttgca cagttacctg cacaccgagt cacggactcc tgcatcgtgg cactcctctc
841 gcatggtgtg gagggcgcca tctatggtgt ggatgggaaa ctgctccagc tccaagaggt
901 ttttcagctc tttgacaacg ccaactgccc aagcctacag aacaaaccaa aaatgttctt
961 catccaggcc tgccgtggag atgagactga tcgtggggtt gaccaacaag atggaaagaa
1021 ccacgcagga tcccctgggt gcgaggagag tgatgccggt aaagaaaagt tgccgaagat
1081 gagactgccc acgcgctcag acatgatatg cggctatgcc tgcctcaaag ggactgccgc
1141 catgcggaac accaaacgag gttcctggta catcgaggct cttgctcaag tgttttctga
1201 gcgggcttgt gatatgcacg tggccgacat gctggttaag gtgaacgcac ttatcaagga
1261 tcgggaaggt tatgctcctg gcacagaatt ccaccggtgc aaggagatgt ctgaatactg
1321 cagcactctg tgccgccacc tctacctgtt cccaggacac cctcccacat gatgtcacct
1381 ccccatcatc cacgccaagt ggaagccact ggaccacagg aggtgtgata gagcctttga
1441 tcttcaggat gcacggtttc tgttctgccc cctcagggat gtgggaatct cccagacttg
1501 tttcctgtgc ccatcatctc tgcctttgag tgtgggactc caggccagct ccttttctgt
1561 gaagcccttt gcctgtagag ccagccttgg ttggacctat tgccaggaat gtttcagctg
1621 cagttgaaga gcctgacaag tgaagttgta aacacagtgt ggttatgggg agagggcata
1681 taaattcccc atatttgtgt tcagttccag cttttgtaga tggcacttta gtgattgctt
1741 ttattacatt agttaagatg tctgagagac catctcctat cttttatttc attcatatcc
1801 tccgcccttt ttgtcctaga gtgagagttt ggaaggtgtc caaatttaat gtagacatta
1861 tcttttggct ctgaagaagc aaacatgact agagacgcac cttgctgcag tgtccagaag
1921 cggcctgtgc gttcccttca gtactgcagc gccacccagt ggaaggacac tcttggctcg
1981 tttgggctca aggcaccgca gcctgtcagc caacattgcc ttgcatttgt accttattga
2041 tctttgccca tggaagtctc aaagatcttt cgttggttgt ttctctgagc tttgttactg
2101 aaatgagcct cgtggggagc atcagagaag gccaggaaga atggtgtgtt tccctagact
2161 ctgtaaccac ctctctgtct ttttccttcc tgagaaacgt ccatctctct cccttactat
2221 tcccactttc attcaatcaa cctgcacttc atatctagat ttctagaaaa gcttcctagc
2281 ttatctccct gcttcatatc tctcccttct ttaccttcat ttcatcctgt tggctgctgc
2341 caccaaatct gtctagaatc ctgctttaca ggatcatgta aatgctcaaa gatgtaatgt
2401 agttctttgt tcctgctttc tctttcagta ttaaactctc ctttgatatt atgtggcttt
2461 tatttcagtg ccatacatgt tattgttttc aacctagaaa cctttatccc tgcttatctg
2521 aaacttccca acttccctga tctttaagac tttttttttt tttttttttt ttttgagaca
2581 gagtctcgct ctgtcgccca ggctggaggg cagtggcacg atctcagctc actgcaagct
2641 ccaactcccg ggttcacgcc attctcctgc ctcagccttc caagtagctg ggactacagg
2701 tgcccgccac cgtgcccggc taattttttt gtatttttag tagagacagg gtttcaccat
2761 gttagccggg atggtcttga tctcctgacc tcatgatcca cccacctcag cctcccaaag
2821 tgttgggatt acaggcgtga gccactgcgc ccgggcaaga ccttttttta aaaaaaaaaa
2881 aaaaaaaa
//