LOCUS BC001645 2672 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens spleen tyrosine kinase, mRNA (cDNA clone MGC:2390
IMAGE:2959066), complete cds.
ACCESSION BC001645
VERSION BC001645.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2672)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2672)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (08-JAN-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 19, 2003 this sequence version replaced BC001645.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Louis M. Staudt, M.D., Ph.D.
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 2 Row: e Column: 10
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 34147655.
FEATURES Location/Qualifiers
source 1..2672
/db_xref="H-InvDB:HIT000030543"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:2390 IMAGE:2959066"
/tissue_type="Lymph, Burkitt lymphoma"
/clone_lib="NIH_MGC_8"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2672
/gene="SYK"
/db_xref="GeneID:6850"
/db_xref="HGNC:HGNC:11491"
/db_xref="MIM:600085"
CDS 148..2055
/gene="SYK"
/codon_start=1
/product="spleen tyrosine kinase"
/protein_id="AAH01645.1"
/db_xref="GeneID:6850"
/db_xref="HGNC:HGNC:11491"
/db_xref="MIM:600085"
/translation="MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQS
RNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCL
LKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIAT
TAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRI
DKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQL
PGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADK
GPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQM
KKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEM
AELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA
KISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAF
SYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVEL
RLRNYYYDVVN"
BASE COUNT 720 a 684 c 725 g 543 t
ORIGIN
1 aggaagagcc gcgggcccgg cggctgaggc caccccggcg gcggctggag agcgaggagg
61 agcgggtggc cccgcgctgc gcccgccctc gcctcacctg gcgcaggtgg acacctgcgc
121 aggtgtgtgc cctccggccc ctgaagcatg gccagcagcg gcatggctga cagcgccaac
181 cacctgccct tctttttcgg caacatcacc cgggaggagg cagaagatta cctggtccag
241 gggggcatga gtgatgggct ttatttgctg cgccagagcc gcaactacct gggtggcttc
301 gccctgtccg tggcccacgg gaggaaggca caccactaca ccatcgagcg ggagctgaat
361 ggcacctacg ccatcgccgg tggcaggacc catgccagcc ccgccgacct ctgccactac
421 cactcccagg agtctgatgg cctggtctgc ctcctcaaga agcccttcaa ccggccccaa
481 ggggtgcagc ccaagactgg gccctttgag gatttgaagg aaaacctcat cagggaatat
541 gtgaagcaga catggaacct gcagggtcag gctctggagc aggccatcat cagtcagaag
601 cctcagctgg agaagctgat cgctaccaca gcccatgaaa aaatgccttg gttccatgga
661 aaaatctctc gggaagaatc tgagcaaatt gtcctgatag gatcaaagac aaatggaaag
721 ttcctgatcc gagccagaga caacaacggc tcctacgccc tgtgcctgct gcacgaaggg
781 aaggtgctgc actatcgcat cgacaaagac aagacaggga agctctccat ccccgaggga
841 aagaagttcg acacgctctg gcagctagtc gagcattatt cttataaagc agatggtttg
901 ttaagagttc ttactgtccc atgtcaaaaa atcggcacac agggaaatgt taattttgga
961 ggccgtccac aacttccagg ttcccatcct gcgacttggt cagcgggtgg aataatctca
1021 agaatcaaat catactcctt cccaaagcct ggccacagaa agtcctcccc tgcccaaggg
1081 aaccggcaag agagtactgt gtcattcaat ccgtatgagc cagaacttgc accctgggct
1141 gcagacaaag gcccccagag agaagcccta cccatggaca cagaggtgta cgagagcccc
1201 tacgcggacc ctgaggagat caggcccaag gaggtttacc tggaccgaaa gctgctgacg
1261 ctggaagaca aagaactggg ctctggtaat tttggaactg tgaaaaaggg ctactaccaa
1321 atgaaaaaag ttgtgaaaac cgtggctgtg aaaatactga aaaacgaggc caatgacccc
1381 gctcttaaag atgagttatt agcagaagca aatgtcatgc agcagctgga caacccgtac
1441 atcgtgcgca tgatcgggat atgcgaggcc gagtcctgga tgctagttat ggagatggca
1501 gaacttggtc ccctcaataa gtatttgcag cagaacagac atgtcaagga taagaacatc
1561 atagaactgg ttcatcaggt ttccatgggc atgaagtact tggaggagag caattttgtg
1621 cacagagatc tggctgcaag aaatgtgttg ctagttaccc aacattatgc caagatcagt
1681 gatttcggac tctccaaagc actgcgtgct gatgaaaact actacaaggc ccagacccat
1741 ggaaagtggc ctgtcaagtg gtacgctccg gaatgcatca actactacaa gttctccagc
1801 aaaagcgatg tctggagctt tggagtgttg atgtgggaag cattctccta tgggcagaag
1861 ccatatcgag ggatgaaagg aagtgaagtc accgctatgt tagagaaagg agagcggatg
1921 gggtgccctg cagggtgtcc aagagagatg tacgatctca tgaatctgtg ctggacatac
1981 gatgtggaaa acaggcccgg attcgcagca gtggaactgc ggctgcgcaa ttactactat
2041 gacgtggtga actaaccgct cccgcacctg tcggtggctg cctttgatca caggagcaat
2101 cacaggaaaa tgtatccaga ggaattgatt gtcagccacc tccctctgcc agtcgggaga
2161 gccaggcttg gatggaacat gcccacaact tgtcacccaa agcctgtccc aggactcacc
2221 ctccacaaag caaaggcagt cccgggagaa aagacggatg gcaggatcca aggggctagc
2281 tggatttgtt tgttttcttg tctgtgtgat tttcatacag gttattttta cgatctgttt
2341 ccaaatccct ttcatgtctt tccacttctc tgggtcccgg ggtgcatttg ttactcatcg
2401 ggcccaggga cattgcagag tggcctagag cactctcacc ccaagcggcc ttttccaaat
2461 gcccaaggat gccttagcat gtgactcctg aagggaaggc aaaggcagag gaatttggct
2521 gcttctacgg ccatgagact gatccctggc cactgaaaag ctttcctgac aataaaaatg
2581 ttttgaggct ttaaaaagaa aatcaagttt gaccagtgca gtttctaagc atgtagccag
2641 ttaaggaaag aaagaaaaaa aaaaaaaaaa aa
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