LOCUS BC001188 5015 bp mRNA linear HUM 04-OCT-2003
DEFINITION Homo sapiens transferrin receptor (p90, CD71), mRNA (cDNA clone
MGC:3151 IMAGE:3354176), complete cds.
ACCESSION BC001188
VERSION BC001188.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5015)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 5015)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (11-DEC-2000) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steven Jones, Jennifer Asano, Ian Bosdet, Yaron Butterfield,
Susanna Chan, Readman Chiu, Chris Fjell, Erin Garland, Ran Guin,
Letticia Hsiao, Martin Krzywinski, Reta Kutsche, Oliver Lee, Soo
Sen Lee, Victor Ling, Carrie Mathewson, Candice McLeavy, Steven
Ness, Pawan Pandoh, Anna-Liisa Prabhu, Parvaneh Saeedi, Jacqueline
Schein, Duane Smailus, Michael Smith, Lorraine Spence, Jeff Stott,
Michael Thorne, Miranada Tsai, Natasja van den Bosch, Jill Vardy,
George Yang, Scott Zuyderduyn, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 6 Row: f Column: 7.
FEATURES Location/Qualifiers
source 1..5015
/db_xref="H-InvDB:HIT000030208"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:3151 IMAGE:3354176"
/tissue_type="Eye, retinoblastoma"
/clone_lib="NIH_MGC_16"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..5015
/gene="TFRC"
/gene_synonym="CD71"
/gene_synonym="TFR"
/gene_synonym="TRFR"
/db_xref="GeneID:7037"
/db_xref="MIM:190010"
CDS 57..2339
/gene="TFRC"
/gene_synonym="CD71"
/gene_synonym="TFR"
/gene_synonym="TRFR"
/codon_start=1
/product="TFRC protein"
/protein_id="AAH01188.1"
/db_xref="GeneID:7037"
/db_xref="MIM:190010"
/translation="MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDE
EENADNNTKANVTKPKRCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLA
GTESPVREEPGEDFPAARRLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQ
KDENLALYVENQFREFKLSKVWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGG
YVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNA
IGVLIYMDQTKFPIVNAELSFFGHAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPV
QTISRAAAEKLFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGV
IKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIF
ASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEK
TMQNVKHPVTGQFLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYL
GTTMDTYKELIERIPELNKVARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRD
LNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVE
YHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRKQNNGAFNETLFRNQLALATW
TIQGAANALSGDVWDIDNEF"
misc_feature 513..1511
/gene="TFRC"
/gene_synonym="CD71"
/gene_synonym="TFR"
/gene_synonym="TRFR"
/note="Iap; Region: Predicted aminopeptidases [General
function prediction only]"
/db_xref="CDD:COG2234"
misc_feature 1899..2312
/gene="TFRC"
/gene_synonym="CD71"
/gene_synonym="TFR"
/gene_synonym="TRFR"
/note="TFR_dimer; Region: Transferring receptor-like
dimerisation domain. This domain is involved in
dimerisation of the transferrin receptor as shown in its
crystal structure"
/db_xref="CDD:pfam04253"
BASE COUNT 1446 a 941 c 1099 g 1529 t
ORIGIN
1 cgggtggcgg ctcgggacgg aggacgcgct agtgttcttc tgtgtggcag ttcagaatga
61 tggatcaagc tagatcagca ttctctaact tgtttggtgg agaaccattg tcatataccc
121 ggttcagcct ggctcggcaa gtagatggcg ataacagtca tgtggagatg aaacttgctg
181 tagatgaaga agaaaatgct gacaataaca caaaggccaa tgtcacaaaa ccaaaaaggt
241 gtagtggaag tatctgctat gggactattg ctgtgatcgt ctttttcttg attggattta
301 tgattggcta cttgggctat tgtaaagggg tagaaccaaa aactgagtgt gagagactgg
361 caggaaccga gtctccagtg agggaggagc caggagagga cttccctgca gcacgtcgct
421 tatattggga tgacctgaag agaaagttgt cggagaaact ggacagcaca gacttcaccg
481 gcaccatcaa gctgctgaat gaaaattcat atgtccctcg tgaggctgga tctcaaaaag
541 atgaaaatct tgcgttgtat gttgaaaatc aatttcgtga atttaaactc agcaaagtct
601 ggcgtgatca acattttgtt aagattcagg tcaaagacag cgctcaaaac tcggtgatca
661 tagttgataa gaacggtaga cttgtttacc tggtggagaa tcctgggggt tatgtggcgt
721 atagtaaggc tgcaacagtt actggtaaac tggtccatgc taattttggt actaaaaaag
781 attttgagga tttatacact cctgtgaatg gatctatagt gattgtcaga gcagggaaaa
841 tcacctttgc agaaaaggtt gcaaatgctg aaagcttaaa tgcaattggt gtgttgatat
901 acatggacca gactaaattt cccattgtta acgcagaact ttcattcttt ggacatgctc
961 atctggggac aggtgaccct tacacacctg gattcccttc cttcaatcac actcagtttc
1021 caccatctcg gtcatcagga ttgcctaata tacctgtcca gacaatctcc agagctgctg
1081 cagaaaagct gtttgggaat atggaaggag actgtccctc tgactggaaa acagactcta
1141 catgtaggat ggtaacctca gaaagcaaga atgtgaagct cactgtgagc aatgtgctga
1201 aagagataaa aattcttaac atctttggag ttattaaagg ctttgtagaa ccagatcact
1261 atgttgtagt tggggcccag agagatgcat ggggccctgg agctgcaaaa tccggtgtag
1321 gcacagctct cctattgaaa cttgcccaga tgttctcaga tatggtctta aaagatgggt
1381 ttcagcccag cagaagcatt atctttgcca gttggagtgc tggagacttt ggatcggttg
1441 gtgccactga atggctagag ggataccttt cgtccctgca tttaaaggct ttcacttata
1501 ttaatctgga taaagcggtt cttggtacca gcaacttcaa ggtttctgcc agcccactgt
1561 tgtatacgct tattgagaaa acaatgcaaa atgtgaagca tccggttact gggcaatttc
1621 tatatcagga cagcaactgg gccagcaaag ttgagaaact cactttagac aatgctgctt
1681 tccctttcct tgcatattct ggaatcccag cagtttcttt ctgtttttgc gaggacacag
1741 attatcctta tttgggtacc accatggaca cctataagga actgattgag aggattcctg
1801 agttgaacaa agtggcacga gcagctgcag aggtcgctgg tcagttcgtg attaaactaa
1861 cccatgatgt tgaattgaac ctggactatg agaggtacaa cagccaactg ctttcatttg
1921 tgagggatct gaaccaatac agagcagaca taaaggaaat gggcctgagt ttacagtggc
1981 tgtattctgc tcgtggagac ttcttccgtg ctacttccag actaacaaca gatttcggga
2041 atgctgagaa aacagacaga tttgtcatga agaaactcaa tgatcgtgtc atgagagtgg
2101 agtatcactt cctctctccc tacgtatctc caaaagagtc tcctttccga catgtcttct
2161 ggggctccgg ctctcacacg ctgccagctt tactggagaa cttgaaactg cgtaaacaaa
2221 ataacggtgc ttttaatgaa acgctgttca gaaaccagtt ggctctagct acttggacta
2281 ttcagggagc tgcaaatgcc ctctctggtg acgtttggga cattgacaat gagttttaaa
2341 tgtgataccc atagcttcca tgagaacagc agggtagtct ggtttctaga cttgtgctga
2401 tcgtgctaaa ttttcagtag ggctacaaaa cctgatgtta aaattccatc ccatcatctt
2461 ggtactacta gatgtcttta ggcagcagct tttaatacag ggtagataac ctgtacttca
2521 agttaaagtg aataaccact taaaaaatgt ccatgatgga atattcccct atctctagaa
2581 ttttaagtgc tttgtaatgg gaactgcctc tttcctgttg ttgttaatga aaatgtcaga
2641 aaccagttat gtgaatgatc tctctgaatc ctaagggctg gtctctgctg aaggttgtaa
2701 gtggtcgctt actttgagtg atcctccaac ttcatttgat gctaaatagg agataccagg
2761 ttgaaagacc ttctccaaat gagatctaag cctttccata aggaatgtag ctggtttcct
2821 cattcctgaa agaaacagtt aactttcaga agagatgggc ttgttttctt gccaatgagg
2881 tctgaaatgg aggtccttct gctggataaa atgaggttca actgttgatt gcaggaataa
2941 ggccttaata tgttaacctc agtgtcattt atgaaaagag gggaccagaa gccaaagact
3001 tagtatattt tcttttcctc tgtcccttcc cccataagcc tccatttagt tctttgttat
3061 ttttgtttct tccaaagcac attgaaagag aaccagtttc aggtgtttag ttgcagactc
3121 agtttgtcag actttaaaga ataatatgct gccaaatttt ggccaaagtg ttaatcttag
3181 gggagagctt tctgtccttt tggcactgag atatttattg tttatttatc agtgacagag
3241 ttcactataa atggtgtttt tttaatagaa tataattatc ggaagcagtg ccttccataa
3301 ttatgacagt tatactgtcg gtttttttta aataaaagca gcatctgcta ataaaaccca
3361 acagatactg gaagttttgc atttatggtc aacacttaag ggttttagaa aacagccgtc
3421 agccaaatgt aattgaataa agttgaagct aagatttaga gatgaattaa atttaattag
3481 gggttgctaa gaagcgagca ctgaccagat aagaatgctg gttttcctaa atgcagtgaa
3541 ttgtgaccaa gttataaatc aatgtcactt aaaggctgtg gtagtactcc tgcaaaattt
3601 tatagctcag tttatccaag gtgtaactct aattcccatt ttgcaaaatt tccagtacct
3661 ttgtcacaat cctaacacat tatcgggagc agtgtcttcc ataatgtata aagaacaagg
3721 tagtttttac ctaccacagt gtctgtatcg gagacagtga tctccatatg ttacactaag
3781 ggtgtaagta attatcggga acagtgtttc ccataatttt cttcatgcaa tgacatcttc
3841 aaagcttgaa gatcgttagt atctaacatg tatcccaact cctataattc cctatctttt
3901 agttttagtt gcagaaacat tttgtggtca ttaagcattg ggtgggtaaa ttcaaccact
3961 gtaaaatgaa attactacaa aatttgaaat ttagcttggg tttttgttac ctttatggtt
4021 tctccaggtc ctctacttaa tgagatagta gcatacattt ataatgtttg ctattgacaa
4081 gtcattttaa ctttatcaca ttatttgcat gttacctcct ataaacttag tgcggacaag
4141 ttttaatcca gaattgacct tttgacttaa agcaggggga ctttgtatag aaggtttggg
4201 ggctgtgggg aaggagagtc ccctgaaggt ctgacacgtc tgcctaccca ttcgtggtga
4261 tcaattaaat gtaggtatga ataagttcga agctccgtga gtgaaccatc attataaacg
4321 tgatgatcag ctgtttgtca tagggcagtt ggaaacggcc tcctagggaa aagttcatag
4381 ggtctcttca ggttcttagt gtcacttacc tagatttaca gcctcacttg aatgtgtcac
4441 tactcacagt ctctttaatc ttcagtttta tctttaatct cctcttttat cttggactga
4501 catttagcgt agctaagtga aaaggtcata gctgagattc ctggttcggg tgttacgcac
4561 acgtacttaa atgaaagcat gtggcatgtt catcgtataa cacaatatga atacagggca
4621 tgcattttgc agcagtgagt ctcttcagaa aacccttttc tacagttagg gttgagttac
4681 ttcctatcaa gccagtacgt gctaacaggc tcaatattcc tgaatgaaat atcagactag
4741 tgacaagctc ctggtcttga gatgtcttct cgttaaggag atgggccttt tggaggtaaa
4801 ggataaaatg aatgagttct gtcatgattc actattctag aacttgcatg acctttactg
4861 tgttagctct ttgaatgttc ttgaaatttt agactttctt tgtaaacaaa taatatgtcc
4921 ttatcattgt ataaaagctg ttatgtgcaa cagtgtggag attccttgtc tgatttaata
4981 aaatacttaa acactgaaaa aaaaaaaaaa aaaaa
//