LOCUS BC001158 2560 bp mRNA linear HUM 04-OCT-2003
DEFINITION Homo sapiens platelet-activating factor acetylhydrolase 2, 40kDa,
mRNA (cDNA clone MGC:1493 IMAGE:3354450), complete cds.
ACCESSION BC001158
VERSION BC001158.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2560)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2560)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (11-DEC-2000) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steven Jones, Jennifer Asano, Ian Bosdet, Yaron Butterfield,
Susanna Chan, Readman Chiu, Chris Fjell, Erin Garland, Ran Guin,
Letticia Hsiao, Martin Krzywinski, Reta Kutsche, Oliver Lee, Soo
Sen Lee, Victor Ling, Carrie Mathewson, Candice McLeavy, Steven
Ness, Pawan Pandoh, Anna-Liisa Prabhu, Parvaneh Saeedi, Jacqueline
Schein, Duane Smailus, Michael Smith, Lorraine Spence, Jeff Stott,
Michael Thorne, Miranada Tsai, Natasja van den Bosch, Jill Vardy,
George Yang, Scott Zuyderduyn, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 6 Row: f Column: 9
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4758877.
FEATURES Location/Qualifiers
source 1..2560
/db_xref="H-InvDB:HIT000030182"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:1493 IMAGE:3354450"
/tissue_type="Eye, retinoblastoma"
/clone_lib="NIH_MGC_16"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2560
/gene="PAFAH2"
/gene_synonym="HSD-PLA2"
/db_xref="GeneID:5051"
/db_xref="MIM:602344"
CDS 126..1304
/gene="PAFAH2"
/gene_synonym="HSD-PLA2"
/codon_start=1
/product="PAFAH2 protein"
/protein_id="AAH01158.1"
/db_xref="GeneID:5051"
/db_xref="MIM:602344"
/translation="MGVNQSVGFPPVTGPHLVGCGDVMEGQNLQGSFFRLFYPCQKAE
ETMEQPLWIPRYEYCTGLAEYLQFNKRCGGLLFNLAVGSCRLPVSWNGPFKTKDSGYP
LIIFSHGLGAFRTLYSAFCMELASRGFVVAVPEHRDRSAATTYFCKQAPEENQPTNES
LQEEWIPFRRVEEGEKEFHVRNPQVHQRVSECLRVLKILQEVTAGQTVFNILPGGLDL
MTLKGNIDMSRVAVMGHSFGGATAILALAKETQFRCAVALDAWMFPLERDFYPKARGP
VFFINTEKFQTMESVNLMKKICAQHEQSRIITVLGSVHRSQTDFAFVTGNLIGKFFST
ETRGSLDPYEGQEVMVRAMLAFLQKHLDLKEDYNQWNNLIEGIGPSLTPGAPHHLSSL
"
misc_feature 126..1268
/gene="PAFAH2"
/gene_synonym="HSD-PLA2"
/note="PAF-AH_p_II; Region: Platelet-activating factor
acetylhydrolase, plasma/intracellular isoform II.
Platelet-activating factor acetylhydrolase (PAF-AH) is a
subfamily of phospholipases A2, responsible for
inactivation of platelet-activating factor through
cleavage of an acetyl group. Three known PAF-AHs are the
brain heterotrimeric PAF-AH Ib, whose catalytic beta and
gamma subunits are aligned in pfam02266, the
extracellular, plasma PAF-AH (pPAF-AH), and the
intracellular PAF-AH isoform II (PAF-AH II). This family
aligns pPAF-AH and PAF-AH II, whose similarity was
previously noted"
/db_xref="CDD:pfam03403"
BASE COUNT 690 a 610 c 663 g 597 t
ORIGIN
1 tgaggaatca gcttggctgg caacaggaag ccgagaggaa accagcaagc ggctgctgtt
61 ctgtgttccc ccatccagcc agcaagttca gctccggcaa gtcatttgat tcacccggtg
121 atgaaatggg ggtcaaccag tctgtgggct ttccacctgt cacaggaccc cacctcgtag
181 gctgtgggga tgtgatggag ggtcagaatc tccaggggag cttctttcga ctcttctacc
241 cctgccaaaa ggcagaggag accatggagc agcccctgtg gattccccgc tatgagtact
301 gcactggcct ggccgagtac ctgcagttta ataagcgctg cgggggcttg ctgttcaacc
361 tggcggtggg atcttgtcgc ctgcctgtta gctggaatgg cccctttaag acaaaggact
421 ctggataccc cttgatcatc ttctcccatg gcctaggagc cttcaggact ttgtattcag
481 ccttctgcat ggagctggcc tcacgtggct ttgtggttgc tgtgccagag cacagggacc
541 ggtcagcggc aaccacctat ttctgcaagc aggccccaga agagaaccag cccaccaatg
601 aatcgctgca ggaggaatgg atccctttcc gtcgagttga ggaaggggag aaggaatttc
661 atgttcggaa tccccaggtg catcagcggg taagcgagtg tttacgggtg ttgaagatcc
721 tgcaagaggt cactgctggg cagactgtct tcaacatctt gcctggtggc ttggatctga
781 tgactttgaa gggcaacatt gacatgagcc gtgtggctgt gatgggacat tcatttggag
841 gggccacagc tattctggct ttggccaagg agacccaatt tcggtgtgcg gtggctctgg
901 atgcttggat gtttcctctg gaacgtgact tttaccccaa ggcccgagga cctgtgttct
961 ttatcaatac tgagaaattc cagacaatgg agagtgtcaa tttgatgaag aagatatgtg
1021 cccagcatga acagtctagg atcataaccg ttcttggttc tgttcatcgg agtcaaactg
1081 actttgcttt tgtgactggc aacttgattg gtaaattctt ctccactgaa acccgtggga
1141 gcctggaccc ctatgaaggg caggaggtta tggtacgggc catgttggcc ttcctgcaga
1201 agcacctcga cctgaaagaa gactataatc aatggaacaa ccttattgaa ggcattggac
1261 cgtcgctcac cccaggggcc ccccaccatc tgtccagcct gtaggcacaa ctggccattt
1321 gtaaagtcac ttcagccaag ttttcatttg ggagctaccc aagggcaccc atgagctcct
1381 atcaagaagt gatcaacgtg accccttttc acagattgaa aggtgtaatc acactgctgc
1441 ttggataact gggtactttg atcttagatt tgatcttaaa atcactttgg gactgggatc
1501 ccttgctgat tgacaaacag actttctggg accttgatgg agtggggaac aagcagtaga
1561 gtgggactgg gggagaccca ggccccgggc tgagcactgt gaggcctgga tgtgaagact
1621 cagcccagcg aagctcattc ccttaccccc ggccagtgct gctgcttcag tggaagagat
1681 gaagccaaag gacagaatga aaatccctac cttcagagac tctagcccag cccaacacca
1741 tctcttccta cctctcagcc ttctccctcc ccagggccac ttgttgaagt ctgagcactt
1801 tatgtaaatt tctaggtgtg agccgtgatc acattttcta tttatttcca agtcttctca
1861 ttgtatggaa catagtacta cttatactta cagtagtaag ttatacttgt gagcccacag
1921 agtggcagac agcatggctc tcacagcaca gggagaaaaa ctgaggtaca cagaggtacc
1981 tcagaagctc tggatgtctt tgggggtttt gctaagtgta tcttgatagg aaacaacaaa
2041 agcaggttga gatggggaag atgacagaac aacagtgtta aatggccatt tgcacaggcc
2101 tttgccacaa cagagaagta gtttggtcag ctaaaactca gctgcagcct ggacagtaga
2161 gcgagacccc atcttaaaaa taaagaaggc tgggcgtggt ggctcatgcc tgtaatccca
2221 gcactttggg aggccaaggc aggcagatca cttaaggcca ggagttcaag accacctggc
2281 caacatggtg aaaccccgtc tctactaaaa atacaaaaaa ttagcctggc gtaatggcag
2341 gcgcctataa tcccagctac tcaggaggct gaagcagaag aatcacttga acctaggagg
2401 cggaggttgc agtgagtcaa gatcgcgcca ctgcactcca gcctgggtga cagagcaaga
2461 ctctgtctta aaaaaaaaaa aagaaaaaga aaaatttaaa ataaataaaa tttaaaaacg
2521 caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//