LOCUS BC001158 2560 bp mRNA linear HUM 04-OCT-2003 DEFINITION Homo sapiens platelet-activating factor acetylhydrolase 2, 40kDa, mRNA (cDNA clone MGC:1493 IMAGE:3354450), complete cds. ACCESSION BC001158 VERSION BC001158.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2560) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 2560) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (11-DEC-2000) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: ATCC cDNA Library Preparation: Rubin Laboratory cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Genome Sequence Centre, BC Cancer Agency, Vancouver, BC, Canada info@bcgsc.bc.ca Steven Jones, Jennifer Asano, Ian Bosdet, Yaron Butterfield, Susanna Chan, Readman Chiu, Chris Fjell, Erin Garland, Ran Guin, Letticia Hsiao, Martin Krzywinski, Reta Kutsche, Oliver Lee, Soo Sen Lee, Victor Ling, Carrie Mathewson, Candice McLeavy, Steven Ness, Pawan Pandoh, Anna-Liisa Prabhu, Parvaneh Saeedi, Jacqueline Schein, Duane Smailus, Michael Smith, Lorraine Spence, Jeff Stott, Michael Thorne, Miranada Tsai, Natasja van den Bosch, Jill Vardy, George Yang, Scott Zuyderduyn, Marco Marra. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAL Plate: 6 Row: f Column: 9 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 4758877. FEATURES Location/Qualifiers source 1..2560 /db_xref="H-InvDB:HIT000030182" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:1493 IMAGE:3354450" /tissue_type="Eye, retinoblastoma" /clone_lib="NIH_MGC_16" /lab_host="DH10B-R" /note="Vector: pOTB7" gene 1..2560 /gene="PAFAH2" /gene_synonym="HSD-PLA2" /db_xref="GeneID:5051" /db_xref="MIM:602344" CDS 126..1304 /gene="PAFAH2" /gene_synonym="HSD-PLA2" /codon_start=1 /product="PAFAH2 protein" /protein_id="AAH01158.1" /db_xref="GeneID:5051" /db_xref="MIM:602344" /translation="MGVNQSVGFPPVTGPHLVGCGDVMEGQNLQGSFFRLFYPCQKAE ETMEQPLWIPRYEYCTGLAEYLQFNKRCGGLLFNLAVGSCRLPVSWNGPFKTKDSGYP LIIFSHGLGAFRTLYSAFCMELASRGFVVAVPEHRDRSAATTYFCKQAPEENQPTNES LQEEWIPFRRVEEGEKEFHVRNPQVHQRVSECLRVLKILQEVTAGQTVFNILPGGLDL MTLKGNIDMSRVAVMGHSFGGATAILALAKETQFRCAVALDAWMFPLERDFYPKARGP VFFINTEKFQTMESVNLMKKICAQHEQSRIITVLGSVHRSQTDFAFVTGNLIGKFFST ETRGSLDPYEGQEVMVRAMLAFLQKHLDLKEDYNQWNNLIEGIGPSLTPGAPHHLSSL " misc_feature 126..1268 /gene="PAFAH2" /gene_synonym="HSD-PLA2" /note="PAF-AH_p_II; Region: Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II. Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in pfam02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted" /db_xref="CDD:pfam03403" BASE COUNT 690 a 610 c 663 g 597 t ORIGIN 1 tgaggaatca gcttggctgg caacaggaag ccgagaggaa accagcaagc ggctgctgtt 61 ctgtgttccc ccatccagcc agcaagttca gctccggcaa gtcatttgat tcacccggtg 121 atgaaatggg ggtcaaccag tctgtgggct ttccacctgt cacaggaccc cacctcgtag 181 gctgtgggga tgtgatggag ggtcagaatc tccaggggag cttctttcga ctcttctacc 241 cctgccaaaa ggcagaggag accatggagc agcccctgtg gattccccgc tatgagtact 301 gcactggcct ggccgagtac ctgcagttta ataagcgctg cgggggcttg ctgttcaacc 361 tggcggtggg atcttgtcgc ctgcctgtta gctggaatgg cccctttaag acaaaggact 421 ctggataccc cttgatcatc ttctcccatg gcctaggagc cttcaggact ttgtattcag 481 ccttctgcat ggagctggcc tcacgtggct ttgtggttgc tgtgccagag cacagggacc 541 ggtcagcggc aaccacctat ttctgcaagc aggccccaga agagaaccag cccaccaatg 601 aatcgctgca ggaggaatgg atccctttcc gtcgagttga ggaaggggag aaggaatttc 661 atgttcggaa tccccaggtg catcagcggg taagcgagtg tttacgggtg ttgaagatcc 721 tgcaagaggt cactgctggg cagactgtct tcaacatctt gcctggtggc ttggatctga 781 tgactttgaa gggcaacatt gacatgagcc gtgtggctgt gatgggacat tcatttggag 841 gggccacagc tattctggct ttggccaagg agacccaatt tcggtgtgcg gtggctctgg 901 atgcttggat gtttcctctg gaacgtgact tttaccccaa ggcccgagga cctgtgttct 961 ttatcaatac tgagaaattc cagacaatgg agagtgtcaa tttgatgaag aagatatgtg 1021 cccagcatga acagtctagg atcataaccg ttcttggttc tgttcatcgg agtcaaactg 1081 actttgcttt tgtgactggc aacttgattg gtaaattctt ctccactgaa acccgtggga 1141 gcctggaccc ctatgaaggg caggaggtta tggtacgggc catgttggcc ttcctgcaga 1201 agcacctcga cctgaaagaa gactataatc aatggaacaa ccttattgaa ggcattggac 1261 cgtcgctcac cccaggggcc ccccaccatc tgtccagcct gtaggcacaa ctggccattt 1321 gtaaagtcac ttcagccaag ttttcatttg ggagctaccc aagggcaccc atgagctcct 1381 atcaagaagt gatcaacgtg accccttttc acagattgaa aggtgtaatc acactgctgc 1441 ttggataact gggtactttg atcttagatt tgatcttaaa atcactttgg gactgggatc 1501 ccttgctgat tgacaaacag actttctggg accttgatgg agtggggaac aagcagtaga 1561 gtgggactgg gggagaccca ggccccgggc tgagcactgt gaggcctgga tgtgaagact 1621 cagcccagcg aagctcattc ccttaccccc ggccagtgct gctgcttcag tggaagagat 1681 gaagccaaag gacagaatga aaatccctac cttcagagac tctagcccag cccaacacca 1741 tctcttccta cctctcagcc ttctccctcc ccagggccac ttgttgaagt ctgagcactt 1801 tatgtaaatt tctaggtgtg agccgtgatc acattttcta tttatttcca agtcttctca 1861 ttgtatggaa catagtacta cttatactta cagtagtaag ttatacttgt gagcccacag 1921 agtggcagac agcatggctc tcacagcaca gggagaaaaa ctgaggtaca cagaggtacc 1981 tcagaagctc tggatgtctt tgggggtttt gctaagtgta tcttgatagg aaacaacaaa 2041 agcaggttga gatggggaag atgacagaac aacagtgtta aatggccatt tgcacaggcc 2101 tttgccacaa cagagaagta gtttggtcag ctaaaactca gctgcagcct ggacagtaga 2161 gcgagacccc atcttaaaaa taaagaaggc tgggcgtggt ggctcatgcc tgtaatccca 2221 gcactttggg aggccaaggc aggcagatca cttaaggcca ggagttcaag accacctggc 2281 caacatggtg aaaccccgtc tctactaaaa atacaaaaaa ttagcctggc gtaatggcag 2341 gcgcctataa tcccagctac tcaggaggct gaagcagaag aatcacttga acctaggagg 2401 cggaggttgc agtgagtcaa gatcgcgcca ctgcactcca gcctgggtga cagagcaaga 2461 ctctgtctta aaaaaaaaaa aagaaaaaga aaaatttaaa ataaataaaa tttaaaaacg 2521 caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa //