LOCUS       BC000627                2654 bp    mRNA    linear   HUM 15-JUL-2006
DEFINITION  Homo sapiens signal transducer and activator of transcription 3
            (acute-phase response factor), mRNA (cDNA clone MGC:1607
            IMAGE:3347434), complete cds.
ACCESSION   BC000627
VERSION     BC000627.2
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2654)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 2654)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-NOV-2000) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     On Aug 20, 2003 this sequence version replaced BC000627.1.
            Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: DCTD/DTP
            cDNA Library Preparation: Rubin Laboratory
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: National Institutes of Health Intramural
            Sequencing Center (NISC),
            Gaithersburg, Maryland;
            Web site: http://www.nisc.nih.gov/
            Contact: nisc_mgc@nhgri.nih.gov
            Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
            Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
            Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
            Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
            Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
            McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
            Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
            Young,A., Zhang,L.-H. and Green,E.D.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAL Plate: 5 Row: o Column: 24
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 47458819.
FEATURES             Location/Qualifiers
     source          1..2654
                     /db_xref="H-InvDB:HIT000029786"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:1607 IMAGE:3347434"
                     /tissue_type="Kidney, renal cell adenocarcinoma"
                     /clone_lib="NIH_MGC_14"
                     /lab_host="DH10B-R"
                     /note="Vector: pOTB7"
     gene            1..2654
                     /gene="STAT3"
                     /gene_synonym="APRF"
                     /gene_synonym="FLJ20882"
                     /gene_synonym="MGC16063"
                     /db_xref="GeneID:6774"
                     /db_xref="HGNC:HGNC:11364"
                     /db_xref="MIM:102582"
     CDS             138..2447
                     /gene="STAT3"
                     /gene_synonym="APRF"
                     /gene_synonym="FLJ20882"
                     /gene_synonym="MGC16063"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     3 (acute-phase response factor)"
                     /protein_id="AAH00627.1"
                     /db_xref="GeneID:6774"
                     /db_xref="HGNC:HGNC:11364"
                     /db_xref="MIM:102582"
                     /translation="MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWA
                     YAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIA
                     RIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQ
                     KMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIV
                     SELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQ
                     TRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPD
                     RPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTK
                     VMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGL
                     KIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVL
                     SWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLD
                     NIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWV
                     EKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEA
                     FGKYCRPESQEHPEADPGAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNG
                     EGAEPSAGGQFESLTFDMELTSECATSPM"
BASE COUNT          727 a          678 c          689 g          560 t
ORIGIN      
        1 ggatcctgga caggcacccc ggcttggcgc tgtctctccc cctcggctcg gagaggccct
       61 tcggcctgag ggagcctcgc cgcccgtccc cggcacacgc gcagccccgg cctctcggcc
      121 tctgccggag aaacaggatg gcccaatgga atcagctaca gcagcttgac acacggtacc
      181 tggagcagct ccatcagctc tacagtgaca gcttcccaat ggagctgcgg cagtttctgg
      241 ccccttggat tgagagtcaa gattgggcat atgcggccag caaagaatca catgccactt
      301 tggtgtttca taatctcctg ggagagattg accagcagta tagccgcttc ctgcaagagt
      361 cgaatgttct ctatcagcac aatctacgaa gaatcaagca gtttcttcag agcaggtatc
      421 ttgagaagcc aatggagatt gcccggattg tggcccggtg cctgtgggaa gaatcacgcc
      481 ttctacagac tgcagccact gcggcccagc aagggggcca ggccaaccac cccacagcag
      541 ccgtggtgac ggagaagcag cagatgctgg agcagcacct tcaggatgtc cggaagagag
      601 tgcaggatct agaacagaaa atgaaagtgg tagagaatct ccaggatgac tttgatttca
      661 actataaaac cctcaagagt caaggagaca tgcaagatct gaatggaaac aaccagtcag
      721 tgaccaggca gaagatgcag cagctggaac agatgctcac tgcgctggac cagatgcgga
      781 gaagcatcgt gagtgagctg gcggggcttt tgtcagcgat ggagtacgtg cagaaaactc
      841 tcacggacga ggagctggct gactggaaga ggcggcaaca gattgcctgc attggaggcc
      901 cgcccaacat ctgcctagat cggctagaaa actggataac gtcattagca gaatctcaac
      961 ttcagacccg tcaacaaatt aagaaactgg aggagttgca gcaaaaagtt tcctacaaag
     1021 gggaccccat tgtacagcac cggccgatgc tggaggagag aatcgtggag ctgtttagaa
     1081 acttaatgaa aagtgccttt gtggtggagc ggcagccctg catgcccatg catcctgacc
     1141 ggcccctcgt catcaagacc ggcgtccagt tcactactaa agtcaggttg ctggtcaaat
     1201 tccctgagtt gaattatcag cttaaaatta aagtgtgcat tgacaaagac tctggggacg
     1261 ttgcagctct cagaggatcc cggaaattta acattctggg cacaaacaca aaagtgatga
     1321 acatggaaga atccaacaac ggcagcctct ctgcagaatt caaacacttg accctgaggg
     1381 agcagagatg tgggaatggg ggccgagcca attgtgatgc ttccctgatt gtgactgagg
     1441 agctgcacct gatcaccttt gagaccgagg tgtatcacca aggcctcaag attgacctag
     1501 agacccactc cttgccagtt gtggtgatct ccaacatctg tcagatgcca aatgcctggg
     1561 cgtccatcct gtggtacaac atgctgacca acaatcccaa gaatgtaaac ttttttacca
     1621 agcccccaat tggaacctgg gatcaagtgg ccgaggtcct gagctggcag ttctcctcca
     1681 ccaccaagcg aggactgagc atcgagcagc tgactacact ggcagagaaa ctcttgggac
     1741 ctggtgtgaa ttattcaggg tgtcagatca catgggctaa attttgcaaa gaaaacatgg
     1801 ctggcaaggg cttctccttc tgggtctggc tggacaatat cattgacctt gtgaaaaagt
     1861 acatcctggc cctttggaac gaagggtaca tcatgggctt tatcagtaag gagcgggagc
     1921 gggccatctt gagcactaag cctccaggca ccttcctgct aagattcagt gaaagcagca
     1981 aagaaggagg cgtcactttc acttgggtgg agaaggacat cagcggtaag acccagatcc
     2041 agtccgtgga accatacaca aagcagcagc tgaacaacat gtcatttgct gaaatcatca
     2101 tgggctataa gatcatggat gctaccaata tcctggtgtc tccactggtc tatctctatc
     2161 ctgacattcc caaggaggag gcattcggaa agtattgtcg gccagagagc caggagcatc
     2221 ctgaagctga cccaggcgct gccccatacc tgaagaccaa gtttatctgt gtgacaccaa
     2281 cgacctgcag caataccatt gacctgccga tgtccccccg cactttagat tcattgatgc
     2341 agtttggaaa taatggtgaa ggtgctgaac cctcagcagg agggcagttt gagtccctca
     2401 cctttgacat ggagttgacc tcggagtgcg ctacctcccc catgtgagga gctgagaacg
     2461 gaagctgcag aaagatacga ctgaggcgcc tacctgcatt ctgccacccc tcacacagcc
     2521 aaaccccaga tcatctgaaa ctactaactt tgtggttcca gatttttttt aatctcctac
     2581 ttctgctatc tttgagcaat ctgggcactt ttaaaaatag agaaatgagt gaaaaaaaaa
     2641 aaaaaaaaaa aaaa
//