LOCUS BC000529 1198 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens growth differentiation factor 15, mRNA (cDNA clone
MGC:8645 IMAGE:2961614), complete cds.
ACCESSION BC000529
VERSION BC000529.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1198)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1198)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (15-NOV-2000) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Nov 6, 2003 this sequence version replaced BC000529.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 1 Row: n Column: 12
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4758935.
FEATURES Location/Qualifiers
source 1..1198
/db_xref="H-InvDB:HIT000029711"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:8645 IMAGE:2961614"
/tissue_type="Muscle, rhabdomyosarcoma"
/clone_lib="NIH_MGC_17"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..1198
/gene="GDF15"
/gene_synonym="GDF-15"
/gene_synonym="MIC-1"
/gene_synonym="MIC1"
/gene_synonym="NAG-1"
/gene_synonym="PDF"
/gene_synonym="PLAB"
/gene_synonym="PTGFB"
/db_xref="GeneID:9518"
/db_xref="HGNC:HGNC:30142"
/db_xref="MIM:605312"
CDS 12..938
/gene="GDF15"
/gene_synonym="GDF-15"
/gene_synonym="MIC-1"
/gene_synonym="MIC1"
/gene_synonym="NAG-1"
/gene_synonym="PDF"
/gene_synonym="PLAB"
/gene_synonym="PTGFB"
/codon_start=1
/product="growth differentiation factor 15"
/protein_id="AAH00529.1"
/db_xref="GeneID:9518"
/db_xref="HGNC:HGNC:30142"
/db_xref="MIM:605312"
/translation="MPGQELRTVNGSQMLLVLLVLSWLPHGGALSLAEASRASFPGPS
ELHSEDSRFRELRKRYEDLLTRLRANQSWEDSNTDLVPAPAVRILTPEVRLGSGGHLH
LRISRAALPEGLPEASRLHRALFRLSPTASRSWDVTRPLRRQLSLARPQAPALHLRLS
PPPSQSDQLLAESSSARPQLELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRA
SLEDLGWADWVLSPREVQVTMCIGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVP
ASYNPMVLIQKTDTGVSLQTYDDLLAKDCHCI"
BASE COUNT 228 a 382 c 360 g 228 t
ORIGIN
1 cctgcacagc catgcccggg caagaactca ggacggtgaa tggctctcag atgctcctgg
61 tgttgctggt gctctcgtgg ctgccgcatg ggggcgccct gtctctggcc gaggcgagcc
121 gcgcaagttt cccgggaccc tcagagttgc actccgaaga ctccagattc cgagagttgc
181 ggaaacgcta cgaggacctg ctaaccaggc tgcgggccaa ccagagctgg gaagattcga
241 acaccgacct cgtcccggcc cctgcagtcc ggatactcac gccagaagtg cggctgggat
301 ccggcggcca cctgcacctg cgtatctctc gggccgccct tcccgagggg ctccccgagg
361 cctcccgcct tcaccgggct ctgttccggc tgtccccgac ggcgtcaagg tcgtgggacg
421 tgacacgacc gctgcggcgt cagctcagcc ttgcaagacc ccaggcgccc gcgctgcacc
481 tgcgactgtc gccgccgccg tcgcagtcgg accaactgct ggcagaatct tcgtccgcac
541 ggccccagct ggagttgcac ttgcggccgc aagccgccag ggggcgccgc agagcgcgtg
601 cgcgcaacgg ggaccactgt ccgctcgggc ccgggcgttg ctgccgtctg cacacggtcc
661 gcgcgtcgct ggaagacctg ggctgggccg attgggtgct gtcgccacgg gaggtgcaag
721 tgaccatgtg catcggcgcg tgcccgagcc agttccgggc ggcaaacatg cacgcgcaga
781 tcaagacgag cctgcaccgc ctgaagcccg acacggtgcc agcgccctgc tgcgtgcccg
841 ccagctacaa tcccatggtg ctcattcaaa agaccgacac cggggtgtcg ctccagacct
901 atgatgactt gttagccaaa gactgccact gcatatgagc agtcctggtc cttccactgt
961 gcacctgcgc ggaggacgcg acctcagttg tcctgccctg tggaatgggc tcaaggttcc
1021 tgagacaccc gattcctgcc caaacagctg tatttatata agtctgttat ttattattaa
1081 tttattgggg tgaccttctt ggggactcgg gggctggtct gatggaactg tgtatttatt
1141 taaaactctg gtgataaaaa taaagctgtc tgaactgtta aaaaaaaaaa aaaaaaaa
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