LOCUS BC000373 3706 bp mRNA linear HUM 04-OCT-2003
DEFINITION Homo sapiens amyloid beta (A4) precursor-like protein 2, mRNA (cDNA
clone MGC:8371 IMAGE:2820109), complete cds.
ACCESSION BC000373
VERSION BC000373.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3706)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3706)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (15-NOV-2000) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 19, 2003 this sequence version replaced BC000373.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 1 Row: c Column: 2
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4502146.
FEATURES Location/Qualifiers
source 1..3706
/db_xref="H-InvDB:HIT000029563"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:8371 IMAGE:2820109"
/tissue_type="Lung, small cell carcinoma"
/clone_lib="NIH_MGC_7"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3706
/gene="APLP2"
/gene_synonym="APPH"
/gene_synonym="APPL2"
/gene_synonym="CDEBP"
/db_xref="GeneID:334"
/db_xref="MIM:104776"
CDS 58..2313
/gene="APLP2"
/gene_synonym="APPH"
/gene_synonym="APPL2"
/gene_synonym="CDEBP"
/codon_start=1
/product="APLP2 protein"
/protein_id="AAH00373.1"
/db_xref="GeneID:334"
/db_xref="MIM:104776"
/translation="MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTG
FAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITN
VMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVC
ENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEE
EDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYD
TFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGK
CVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTNDVDVYFETSADDNEHARFQK
AKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQ
QLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTI
RHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQ
EQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFHPFPALPENEGSGVGEQDGGLI
GAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSA
LIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYEN
PTYKYLEQMQI"
misc_feature 181..669
/gene="APLP2"
/gene_synonym="APPH"
/gene_synonym="APPL2"
/gene_synonym="CDEBP"
/note="A4_EXTRA; Region: amyloid A4"
/db_xref="CDD:smart00006"
misc_feature 982..1140
/gene="APLP2"
/gene_synonym="APPH"
/gene_synonym="APPL2"
/gene_synonym="CDEBP"
/note="KU; Region: BPTI/Kunitz family of serine protease
inhibitors. Serine protease inhibitors. One member of the
family is encoded by an alternatively-spliced form of
Alzheimer's amyloid beta-protein"
/db_xref="CDD:smart00131"
BASE COUNT 1002 a 833 c 965 g 906 t
ORIGIN
1 gcgaggagtc cgagtgtgtg agcttgagag ccgcgcgcta gagcgacccg gcgagggatg
61 gcggccaccg ggaccgcggc cgccgcagcc acgggcaggc tcctgcttct gctgctggtg
121 gggctcacgg cgcctgcctt ggcgctggcc ggctacatcg aggctcttgc agccaatgcc
181 ggaacaggat ttgctgttgc tgagcctcaa atcgcaatgt tttgtgggaa gttaaatatg
241 catgtgaaca ttcagactgg gaaatgggaa cctgatccaa caggcaccaa gagctgcttt
301 gaaacaaaag aagaagttct tcagtactgt caggagatgt atccagagct acagatcaca
361 aatgtgatgg aggcaaacca gcgggttagt attgacaact ggtgccggag ggacaaaaag
421 caatgcaaga gtcgctttgt tacacctttc aagtgtctcg tgggtgaatt tgtaagtgat
481 gtcctgctag ttccagaaaa gtgccagttt ttccacaaag agcggatgga ggtgtgtgag
541 aatcaccagc actggcacac ggtagtcaaa gaggcatgtc tgactcaggg aatgacctta
601 tatagctacg gcatgctgct cccatgtggg gtagaccagt tccatggcac tgaatatgtg
661 tgctgccctc agacaaagat tattggatct gtgtcaaaag aagaggaaga ggaagatgaa
721 gaggaagagg aagaggaaga tgaagaggaa gactatgatg tttataaaag tgaatttcct
781 actgaagcag atctggaaga cttcacagaa gcagctgtgg atgaggatga tgaggatgag
841 gaagaagggg aggaagtggt ggaggaccga gattactact atgacacctt caaaggagat
901 gactacaatg aggagaatcc tactgaaccc ggcagcgacg gcaccatgtc agacaaggaa
961 attactcatg atgtcaaagc tgtctgctcc caggaggcga tgacggggcc ctgccgggcc
1021 gtgatgcctc gttggtactt cgacctctcc aagggaaagt gcgtgcgctt tatatatggt
1081 ggctgcggcg gcaacaggaa caattttgag tctgaggatt attgtatggc tgtgtgtaaa
1141 gcgatgattc ctccaactcc tctgccaacc aatgatgttg atgtgtattt cgagacctct
1201 gcagatgata atgagcatgc tcgcttccag aaggctaagg agcagctgga gattcggcac
1261 cgcaaccgaa tggacagggt aaagaaggaa tgggaagagg cagagcttca agctaagaac
1321 ctccccaaag cagagaggca gactctgatt cagcacttcc aagccatggt taaagcttta
1381 gagaaggaag cagccagtga gaagcagcag ctggtggaga cccacctggc ccgagtggaa
1441 gctatgctga atgaccgccg tcggatggct ctggagaact acctggctgc cttgcagtct
1501 gacccgccac ggcctcatcg cattctccag gccttacggc gttatgtccg tgctgagaac
1561 aaagatcgct tacataccat ccgtcattac cagcatgtgt tggctgttga cccagaaaag
1621 gcggcccaga tgaaatccca ggtgatgaca catctccacg tgattgaaga aaggaggaac
1681 caaagcctct ctctgctcta caaagtacct tatgtagccc aagaaattca agaggaaatt
1741 gatgagctcc ttcaggagca gcgtgcagat atggaccagt tcactgcctc aatctcagag
1801 acccctgtgg acgtccgggt gagctctgag gagagtgagg agatcccacc gttccacccc
1861 ttccacccct tcccagccct acctgagaac gaaggatctg gagtgggaga gcaggatggg
1921 ggactgatcg gtgccgaaga gaaagtgatt aacagtaaga ataaagtgga tgaaaacatg
1981 gtcattgacg agactctgga tgttaaggaa atgattttca atgccgagag agttggaggc
2041 ctcgaggaag agcgggaatc cgtgggccca ctgcgggagg acttcagtct gagtagcagt
2101 gctctcattg gcctgctggt catcgcagtg gccattgcca cggtcatcgt catcagcctg
2161 gtgatgctga ggaagaggca gtatggcacc atcagccacg ggatcgtgga ggttgatcca
2221 atgctcaccc cagaagagcg tcacctgaac aagatgcaga accatggcta tgagaacccc
2281 acctacaaat acctggagca gatgcagatt taggtggcag ggagcgcggc agccctggcg
2341 gagggatgca ggtgggccgg aagatcccac gattccgatc gactgccaag cagcagccgc
2401 tgccaggggc tgcgtctgac atcctgacct cctggactgt aggactatat aaagtactac
2461 tgtagaactg caatttccat tcttttaaat gggtgaaaga tggtaatata acaatatatg
2521 atatataaac cttaaatgaa aaaaatgatc tattgcagat atttgatgta gttttctttt
2581 ttaaattaat cagaaacccc acttccattg tattgtctga cacatgctct caatatataa
2641 taaatgggaa atgtcgattt tcaataatag acttatatgc aggctgtcgt tccggttatg
2701 ttgtgtaagt caactcttca gcctcattca ctgtcctggc ttttatttaa agaaaaaaaa
2761 ggcagtattc cctttttaaa tgagctttca ggaagttgct gagaaatggg gtggaatagg
2821 gaactgtaat ggccactgaa gcacgtgaga gaccctcgca aaatgatgtg aaaggaccag
2881 tttcttgaag tccagtgttt ccacggctgg atacctgtgt gtctccataa aagtcctgtc
2941 accaaggacg ttaaaggcat tttattccag cgtcttctag agagcttagt gtatacagat
3001 gagggtgtcc gctgctgctt tccttcggaa tccagtgctt ccacagagat tagcctgtag
3061 cttatatttg acattcttca ctgtctgttg tttacctacc gtagcttttt accgttcact
3121 tccccttcca actatgtcca gatgtgcagg ctcctcctct ctggactttc tccaaaggca
3181 ctgaccctcg gcctctactt tgtcccctca cctccacccc ctcctgtcac cggccttgtg
3241 acattcactc agagaagacc acaccaagga ggcggccgct ggcccaggag agaacacggg
3301 gaggtttgtt tgtgtgaaag gaaagtagtc caggctgtcc ctgaaactga gtctgtggac
3361 actgtggaaa gctttgaaca attgtgtttt cgtcacagga gtctttgtaa tgcttgtaca
3421 gttgatgtcg atgctcactg cttctgcttt ttctttcttt ttattttaaa tctgaaggtt
3481 ctggtaacct gtggtgtatt tttattttcc tgtgactgtt tttgttttgt ttttttcctt
3541 tttcctcccc tttgacccta ttcatgtctc tacccactat gcacagatta aacttcacct
3601 acaaactcct taatatgatc tgtggagaat gtacacagtt taaacacatc aataaatact
3661 ttaacttcct aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//