LOCUS Y00545 6442 bp DNA linear BCT 14-NOV-2006 DEFINITION Bordetella pertussis cya gene for calmodulin-sensitive adenylate cyclase. ACCESSION Y00545 VERSION Y00545.1 KEYWORDS adenylate cyclase; cya gene; toxin. SOURCE Bordetella pertussis ORGANISM Bordetella pertussis Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Alcaligenaceae; Bordetella. REFERENCE 1 (bases 1 to 6442) AUTHORS Danchin A. JOURNAL Submitted (05-JAN-1988) to the INSDC. Danchin A., Regulation de l'Expression Genetique , Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris, France. REFERENCE 2 (bases 1 to 6442) AUTHORS Glaser P., Ladant D., Sezer O., Pichot F., Ullmann A., Danchin A. TITLE The calmodulin-sensitive adenylate cyclase of Bordetella pertussis: cloning and expression in Escherichia coli JOURNAL Mol. Microbiol. 2(1), 19-30(1988). PUBMED 2897067 REFERENCE 4 (bases 1 to 6442) AUTHORS Munier H., Gilles A.M., Glaser P., Krin E., Danchin A., Sarfati R., Barzu O. TITLE Isolation and characterization of catalytic and calmodulin-binding domains of Bordetella pertussis adenylate cyclase JOURNAL Eur. J. Biochem. 196(2), 469-474(1991). PUBMED 2007407 COMMENT Data kindly reviewed (13-JUN-1988) by Danchin A. Ref. [3] and [4] refer to position 2178. FEATURES Location/Qualifiers source 1..6442 /organism="Bordetella pertussis" /strain="18323" /mol_type="genomic DNA" /clone="pDIA4, pDIA5, pDIA6, pDIA7 and pDIA8" /db_xref="taxon:520" regulatory 828..833 /note="pot. -35 region" /regulatory_class="promoter" regulatory 834..839 /note="pot. alt. -35 region" /regulatory_class="promoter" regulatory 853..858 /note="pot. -10 region" /regulatory_class="promoter" regulatory 855..860 /note="pot. alt. -10 region" /regulatory_class="promoter" misc_feature 865..867 /note="transcription initiation site" CDS 981..6101 /transl_table=11 /note="calmodulin-sensitive adenylate cyclase (AA 1-1706)" /db_xref="GOA:J7QLC0" /db_xref="InterPro:IPR001343" /db_xref="InterPro:IPR003995" /db_xref="InterPro:IPR005165" /db_xref="InterPro:IPR011049" /db_xref="InterPro:IPR018504" /db_xref="InterPro:IPR018511" /db_xref="InterPro:IPR035099" /db_xref="InterPro:IPR037017" /db_xref="PDB:5CVW" /db_xref="UniProtKB/Swiss-Prot:J7QLC0" /protein_id="CAA68613.1" /translation="MQQSHQAGYANAADRESGIPAAVLDGIKAVAKEKNATLMFRLVN PHSTSLIAEGVATKGLGVHAKSSDWGLQAGYIPVNPNLSKLFGRAPEVIARADNDVNS SLAHGHTAVDLTLSKERLDYLRQAGLVTGMADGVVASNHAGYEQFEFRVKETSDGRYA VQYRRKGGDDFEAVKVIGNAAGIPLTADIDMFAIMPHLSNFRDSARSSVTSGDSVTDY LARTRRAASEATGGLDRERIDLLWKIARAGARSAVGTEARRQFRYDGDMNIGVITDFE LEVRNALNRRAHAVGAQDVVQHGTEQNNPFPEADEKIFVVSATGESQMLTRGQLKEYI GQQRGEGYVFYENRAYGVAGKSLFDDGLGAAPGVPSGRSKFSPDVLETVPASPGLRRP SLGAVERQDSGYDSLDGVGSRSFSLGEVSDMAAVEAAELEMTRQVLHAGARQDDAEPG VSGASAHWGQRALQGAQAVAAAQRLVHAIALMTQFGRAGSTNTPQEAASLSAAVFGLG EASSAVAETVSGFFRGSSRWAGGFGVAGGAMALGGGIAAAVGAGMSLTDDAPAGQKAA AGAEIALQLTGGTVELASSIALALAAARGVTSGLQVAGASAGAAAGALAAALSPMEIY GLVQQSHYADQLDKLAQESSAYGYEGDALLAQLYRDKTAAEGAVAGVSAVLSTVGAAV SIAAAASVVGAPVAVVTSLLTGALNGILRGVQQPIIEKLANDYARKIDELGGPQAYFE KNLQARHEQLANSDGLRKMLADLQAGWNASSVIGVQTTEISKSALELAAITGNADNLK SVDVFVDRFVQGERVAGQPVVLDVAAGGIDIASRKGERPALTFITPLAAPGEEQRRRT KTGKSEFTTFVEIVGKQDRWRIRDGAADTTIDLAKVVSQLVDANGVLKHSIKLDVIGG DGDDVVLANASRIHYDGGAGTNTVSYAALGRQDSITVSADGERFNVRKQLNNANVYRE GVATQTTAYGKRTENVQYRHVELARVGQVVEVDTLEHVQHIIGGAGNDSITGNAHDNF LAGGSGDDRLDGGAGNDTLVGGEGQNTVIGGAGDDVFLQDLGVWSNQLDGGAGVDTVK YNVHQPSEERLERMGDTGIHADLQKGTVEKWPALNLFSVDHVKNIENLHGSRLNDRIA GDDQDNELWGHDGNDTIRGRGGDDILRGGLGLDTLYGEDGNDIFLQDDETVSDDIDGG AGLDTVDYSAMIHPGRIVAPHEYGFGIEADLSREWVRKASALGVDYYDNVRNVENVIG TSMKDVLIGDAQANTLMGQGGDDTVRGGDGDDLLFGGDGNDMLYGDAGNDTLYGGLGD DTLEGGAGNDWFGQTQAREHDVLRGGDGVDTVDYSQTGAHAGIAAGRIGLGILADLGA GRVDKLGEAGSSAYDTVSGIENVVGTELADRITGDAQANVLRGAGGADVLAGGEGDDV LLGGDGDDQLSGDAGRDRLYGEAGDDWFFQDAANAGNLLDGGDGRDTVDFSGPGRGLD AGAKGVFLSLGKGFASLMDEPETSNVLRNIENAVGSARDDVLIGDAGANVLNGLAGND VLSGGAGDDVLLGDEGSDLLSGDAGNDDLFGGQGDDTYLFGVGYGHDTIYESGGGHDT IRINAGADQLWFARQGNDLEIRILGTDDALTVHDWYRDADHRVEIIHAANQAVDQAGI EKLVEAMAQYPDPGAAAAAPPAARVPDTLMQSLAVNWR" misc_feature 2061..3716 /note="domain II; Ala /Gly rich (AA 361 - 912)" variation 2178 /replace="t" /note="permits isolation of calmodulin-sensitive adenylate cyclase catalytic domain" /citation=[4] misc_feature 3717..5951 /note="domain III; (AA 913 - 1656)" misc_feature 5952..6098 /note="domain IV; Asp /Gly rich (AA 1657 - 1706)" BASE COUNT 1148 a 1951 c 2270 g 1073 t ORIGIN 1 tgcgatcatt cggcatgtac ggtccagctg cgcgcgagcg gcggccgcgt ccagcgcgcg 61 gcctcggtac tccttgacgc gcgcggtgtc gccgccgcgc cgaacgcgca gcgaacggcc 121 cacgctgtcg gggtgccgtt cggccagcgc gcggcgcagc gcacgattgt cgtcgcgcga 181 gaatggcgcg atccagtcga tgatccacag tcggtcgccg cagttccagg cattcccgcc 241 cagcgacgag ggcgccatga cataggagag ttcggtgtcg gcgtccatta gggcccagct 301 gcagtatgca accggcacgt cattgcatcg cagcagaatg tattggccca gttgaatcgg 361 cgcgagcgct gttgcgtgcg agcagatgca ccggccagtc gcggtgcatg ggagagttca 421 tccacagcca ggcaatattg cccagtgccg cgaagtcgtc ggtgggattg aggagggagg 481 gcgcttgggc ggacggaagc atgacatcgg tgcatggtgg agcggggggc atattccgtg 541 ttgggtgcgc gcatggcaag ccgccggcgc atcatggttg cgccggaatg gcttttctta 601 catgtttcca ggatatgtcc gtatttcggg cgatgcctcg gtcgcggcgc ctgcttttgt 661 cgaacatgtg caatgttgtt gtcgcgatcg cgttggcgct tgctcgctta tttatctccc 721 ttgaagcctt gttcttcttt tcattagaaa gaaatatgcg ctttgtgttt aggatgattt 781 tcctgtccga gtagggtgga tccaaatttt ccggattggt gggaatttgt gcattttcac 841 tgcgaatgtt ggaataattt cgcccatcgt catacgacat gctggatgtt tggttcttgc 901 agaaggatga ggttctgagc gctacacacc ggttgcgtcg gtgcgaatcc gttcaatcga 961 ctacttatcg acagatccac atgcagcaat cgcatcaggc tggttacgca aacgccgccg 1021 accgggagtc tggcatcccc gcagccgtac tcgatggcat caaggccgtg gcgaaggaaa 1081 aaaacgccac attgatgttc cgcctggtca acccccattc caccagcctg attgccgaag 1141 gggtggccac caaaggattg ggcgtgcacg ccaagtcgtc cgattggggg ttgcaggcgg 1201 gctacattcc cgtcaacccg aatctttcca aactgttcgg ccgtgcgccc gaggtgatcg 1261 cgcgggccga caacgacgtc aacagcagcc tggcgcatgg ccataccgcg gtcgacctga 1321 cgctgtcgaa agagcggctt gactatctgc ggcaagcggg cctggtcacc ggcatggccg 1381 atggcgtggt cgcgagcaac cacgcaggct acgagcagtt cgagtttcgc gtgaaggaaa 1441 cctcggacgg gcgctatgcc gtgcagtatc gccgcaaggg cggcgacgat ttcgaggcgg 1501 tcaaggtgat cggcaatgcc gccggtattc cactgacggc ggatatcgac atgttcgcca 1561 ttatgccgca tctgtccaac ttccgcgact cggcgcgcag ttcggtgacc agcggcgatt 1621 cggtgaccga ttacctggcg cgcacgcggc gggccgccag cgaggccacg ggcggcctgg 1681 atcgcgaacg catcgacttg ttgtggaaaa tcgctcgcgc cggcgcccgt tccgcagtgg 1741 gcaccgaggc gcgtcgccag ttccgctacg acggcgacat gaatatcggc gtgatcaccg 1801 atttcgagct ggaagtgcgc aatgcgctga acaggcgggc gcacgccgtc ggcgcgcagg 1861 acgtggtcca gcatggcact gagcagaaca atcctttccc ggaggcagat gagaagattt 1921 tcgtcgtatc ggccaccggt gaaagccaga tgctcacgcg cgggcaactg aaggaataca 1981 ttggccagca gcgcggcgag ggctatgtct tctacgagaa ccgtgcatac ggcgtggcgg 2041 ggaaaagcct gttcgacgat gggctgggag ccgcgcccgg cgtgccgagc ggacgttcga 2101 agttctcgcc ggatgtactg gaaacggtgc cggcgtcacc cggattgcgg cggccgtcgc 2161 tgggcgcagt ggaacgccag gattccggct atgacagcct tgatggggtg ggatcgcgat 2221 cgttctcgtt gggcgaggtg tccgacatgg ccgccgtgga agcggcggaa ctggaaatga 2281 cccggcaagt cttgcacgcc ggggcgcggc aggacgatgc cgagccgggc gtgagcggtg 2341 cgtcggcgca ctgggggcag cgggcgctgc agggcgccca ggcggtggcg gcggcgcagc 2401 ggctggttca tgccattgcc ctgatgacgc aattcggccg ggccggttcc accaacacgc 2461 cgcaggaagc ggcctcgttg tcggcggccg tgttcggctt gggcgaggcc agcagcgccg 2521 tggccgaaac cgtgagcggt tttttccgcg ggtcttcgcg ctgggccggc ggtttcggcg 2581 tggctggcgg cgcgatggcg ctgggaggcg gcatcgccgc ggccgttggc gccgggatgt 2641 cgttgaccga tgacgcgccg gccggacaga aggccgccgc cggcgccgag atcgcgctgc 2701 agttgacagg tggaacggtc gagctggctt cttccatcgc gttggcgctg gccgcggcgc 2761 gcggcgtgac cagcggcttg caggtggccg gggcgtcggc cggggcggct gccggcgcat 2821 tggccgcggc gctcagtccc atggagatct acggcctggt gcagcaatcg cactatgcgg 2881 atcagctgga caagctggcg caggaatcga gcgcatacgg ttacgagggc gacgccttgc 2941 tggcccagct gtatcgcgac aagacggccg ccgagggcgc cgtcgccggc gtctccgccg 3001 tcctgagcac ggtgggggcg gcggtgtcga tcgccgcggc ggccagcgtg gtaggggccc 3061 cggtggcggt ggtcacttcc ttgctgaccg gggctctcaa cggcatcctg cgcggcgtgc 3121 agcagcccat catcgaaaag ctggccaacg attacgctcg caagatcgac gagctgggcg 3181 ggccgcaagc gtacttcgag aaaaacctgc aggcgcgtca cgaacaactg gccaattcgg 3241 acggcctacg gaaaatgctg gccgacctgc aggccggttg gaacgccagc agcgtgatcg 3301 gggtgcagac gacagagatc tccaagtcgg cgctcgaact ggccgccatt accggcaacg 3361 cggacaacct gaaatccgtc gacgtgttcg tggaccgctt cgtccagggc gagcgggtgg 3421 ccggccagcc ggtggtcctc gacgtcgccg ccggcggcat cgatatcgcc agccgcaagg 3481 gcgagcggcc ggcgctgacg ttcatcacgc cgctggccgc gccaggagaa gagcagcgcc 3541 ggcgcacgaa aacgggcaag agcgaattca ccacattcgt cgagatcgtg ggcaagcagg 3601 accgctggcg catccgggac ggcgcggccg acaccaccat cgatctggcc aaggtggtgt 3661 cgcaactggt cgacgccaat ggcgtgctca agcacagcat caaactggat gtgatcggcg 3721 gagatggcga tgacgtcgtg cttgccaatg cttcgcgcat ccattatgac ggcggcgcgg 3781 gcaccaacac ggtcagctat gccgccctgg gtcgacagga ttccattacc gtgtccgccg 3841 acggggaacg tttcaacgtg cgcaagcagt tgaacaacgc caacgtgtat cgcgaaggcg 3901 tggctaccca gacaaccgcc tacggcaagc gcacggagaa tgtccaatac cgccatgtcg 3961 agctggcccg tgtcgggcaa gtggtggagg tcgacacgct cgagcatgtg cagcacatca 4021 tcggcggggc cggcaacgat tcgatcaccg gcaatgcgca cgacaacttc ctagccggcg 4081 ggtcgggcga cgacaggctg gatggcggcg ccggcaacga caccctggtt ggcggcgagg 4141 gccaaaacac ggtcatcggc ggcgccggcg acgacgtatt cctgcaggac ctgggggtat 4201 ggagcaacca gctcgatggc ggcgcgggcg tcgataccgt gaagtacaac gtgcaccagc 4261 cttccgagga gcgcctcgaa cgcatgggcg acacgggcat ccatgccgat cttcaaaagg 4321 gcacggtcga gaagtggccg gccctgaacc tgttcagcgt cgaccatgtc aagaatatcg 4381 agaatctgca cggctcccgc ctaaacgacc gcatcgccgg cgacgaccag gacaacgagc 4441 tctggggcca cgatggcaac gacacgatac gcggccgggg cggcgacgac atcctgcgcg 4501 gcggcctggg cctggacacg ctgtatggcg aggacggcaa cgacatcttc ctgcaggacg 4561 acgagaccgt cagcgatgac atcgacggcg gcgcggggct ggacaccgtc gactactccg 4621 ccatgatcca tccaggcagg atcgttgcgc cgcatgaata cggcttcggg atcgaggcgg 4681 acctgtccag ggaatgggtg cgcaaggcgt ccgcgctggg cgtggactat tacgataatg 4741 tccgcaatgt cgaaaacgtc atcggtacga gcatgaagga tgtgctcatc ggcgacgcgc 4801 aagccaatac cctgatgggc cagggcggcg acgataccgt gcgcggcggc gacggcgatg 4861 atctgctgtt cggcggcgac ggcaacgaca tgctgtatgg cgacgccggc aacgacaccc 4921 tctacggggg gctgggcgac gatacccttg aaggcggcgc gggcaacgat tggttcggcc 4981 agacgcaggc gcgcgagcat gacgtgctgc gcggcggaga tggggtggat accgtcgatt 5041 acagccagac cggcgcgcat gccggcattg ccgcgggtcg catcgggctg ggcatcctgg 5101 ctgacctggg cgccggccgc gtcgacaagc tgggcgaggc cggcagcagc gcctacgata 5161 cggtttccgg tatcgagaac gtggtgggca cggaactggc cgaccgcatc acgggcgatg 5221 cgcaggccaa cgtgctgcgc ggcgcgggtg gcgccgacgt gcttgcgggc ggcgagggcg 5281 acgatgtgct gctgggcggc gacggcgacg accagctgtc gggcgacgcc ggacgcgatc 5341 gcttgtacgg cgaagccggt gacgactggt tcttccagga tgccgccaat gccggcaatc 5401 tgctcgacgg cggcgacggc cgcgataccg tggatttcag cggcccgggc cggggcctcg 5461 acgccggcgc aaagggcgta ttcctgagct tgggcaaggg gttcgccagc ctgatggacg 5521 aacccgaaac cagcaacgtg ttgcgcaata tcgagaacgc cgtgggcagc gcgcgtgatg 5581 acgtgctgat cggcgacgca ggcgccaacg tcctcaatgg cctggcgggc aacgacgtgc 5641 tgtccggcgg cgctggcgac gatgtgctgc tgggcgacga gggctcggac ctgctcagcg 5701 gcgatgcggg caacgacgat ctgttcggcg ggcagggcga tgatacttat ctgttcgggg 5761 tcgggtacgg gcacgacacg atctacgaat cgggcggcgg ccatgacacc atccgcatca 5821 acgcgggggc ggaccagctg tggttcgcgc gccagggcaa cgacctggag atccgcattc 5881 tcggcaccga cgatgcactt accgtgcacg actggtatcg cgacgccgat caccgggtgg 5941 aaatcatcca tgccgccaac caggcggtag accaggcagg catcgaaaag ctggtcgagg 6001 caatggcgca gtatccggac cccggcgcgg cggcggctgc cccgccggcg gcgcgcgtgc 6061 cggacacgct gatgcagtcc ctggctgtca actggcgctg aagcgccgtg aatcacggcc 6121 cgcctgcctc gcgcggcggc gccgtctctt tgcgttcttc tccgaggtat ttcccatcat 6181 gacgtcgccc gcggcgcaat gcgccagcgt gcccgattcc gggttgctct gcctggtcat 6241 gctggctcgc tatcacggat tggcagccga tcccgagcag ttgcggcatg agttcgccga 6301 gaggcattct gtagcgaaac gatacagcct ggcggcgcgc cgggtcggcc tgaaagtgcg 6361 gcggcaccga cccgcgccgg cgcggctgcc acgcgcgccg ctgccggcca tcgcgctgga 6421 ccggtagggc ggctactttg tt //