LOCUS       X98102                  1018 bp    DNA     linear   BCT 14-NOV-2006
DEFINITION  Klebsiella pneumoniae blaSHV-2a gene, strain KPLA-10.
ACCESSION   X98102
VERSION     X98102.1
KEYWORDS    beta-lactamase; Plasmid.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella.
REFERENCE   1
  AUTHORS   Nuesch-Inderbinen M., Kayser F.H., Hachler H.
  TITLE     Survey and molecular genetics of SHV beta-lactamases in
            Enterobacteriaceae in Switzerland: two novel enzymes, SHV-11 and
            SHV-12
  JOURNAL   Antimicrob. Agents Chemother. 41(5), 943-949(1997).
   PUBMED   9145849
REFERENCE   2  (bases 1 to 1018)
  AUTHORS   Nuesch-Inderbinen M.
  JOURNAL   Submitted (23-MAY-1996) to the INSDC. M. Nuesch-Inderbinen,
            University of Zurich, Institute of Medical Microbiology,
            Gloriastrasse 32, CH-8028 Zurich, SWITZERLAND
COMMENT     Related sequences:X55640, M59181, X53433, X53817 and X84314.
FEATURES             Location/Qualifiers
     source          1..1018
                     /organism="Klebsiella pneumoniae"
                     /strain="KPLA-10"
                     /mol_type="genomic DNA"
                     /note="Plasmid"
                     /db_xref="taxon:573"
     regulatory      11..16
                     /regulatory_class="minus_10_signal"
     regulatory      57..64
                     /regulatory_class="ribosome_binding_site"
     CDS             74..934
                     /transl_table=11
                     /gene="blaSHV-2a"
                     /product="beta-lactamase SHV-2a"
                     /function="antibiotic resistance gene"
                     /db_xref="GOA:P0A9Z8"
                     /db_xref="InterPro:IPR000871"
                     /db_xref="InterPro:IPR012338"
                     /db_xref="InterPro:IPR023650"
                     /db_xref="UniProtKB/Swiss-Prot:P0A9Z8"
                     /protein_id="CAA66730.1"
                     /translation="MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIE
                     MDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYS
                     PVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDR
                     WETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIR
                     SVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGI
                     GAALIEHWQR"
     variation       727
                     /replace="c"
                     /note="silent point mutation"
BASE COUNT          194 a          315 c          320 g          189 t
ORIGIN      
        1 aacgccgggt tattcttatt tgtcgcttct ttactcgcct ttatcggcct tcactcaagg
       61 atgtattgtg gttatgcgtt atattcgcct gtgtattatc tccctgttag ccaccctgcc
      121 gctggcggta cacgccagcc cgcagccgct tgagcaaatt aaacaaagcg aaagccagct
      181 gtcgggccgc gtaggcatga tagaaatgga tctggccagc ggccgcacgc tgaccgcctg
      241 gcgcgccgat gaacgctttc ccatgatgag cacctttaaa gtagtgctct gcggcgcagt
      301 gctggcgcgg gtggatgccg gtgacgaaca gctggagcga aagatccact atcgccagca
      361 ggatctggtg gactactcgc cggtcagcga aaaacacctt gccgacggca tgacggtcgg
      421 cgaactctgc gccgccgcca ttaccatgag cgataacagc gccgccaatc tgctactggc
      481 caccgtcggc ggccccgcag gattgactgc ctttttgcgc cagatcggcg acaacgtcac
      541 ccgccttgac cgctgggaaa cggaactgaa tgaggcgctt cccggcgacg cccgcgacac
      601 cactaccccg gccagcatgg ccgcgaccct gcgcaagctg ctgaccagcc agcgtctgag
      661 cgcccgttcg caacggcagc tgctgcagtg gatggtggac gatcgggtcg ccggaccgtt
      721 gatccgttcc gtgctgccgg cgggctggtt tatcgccgat aagaccggag ctagcgagcg
      781 gggtgcgcgc gggattgtcg ccctgcttgg cccgaataac aaagcagagc gcattgtggt
      841 gatttatctg cgggatacgc cggcgagcat ggccgagcga aatcagcaaa tcgccgggat
      901 cggcgcggcg ctgatcgagc actggcaacg ctaagccggc ggtggccgcg cgcgttatcc
      961 ggcccgcagc acctcgcagg cgtgccgggc gatatgactg gcggcggcat cggaaaga
//