LOCUS X81123 11453 bp DNA linear BCT 23-OCT-2008 DEFINITION Escherichia coli plasmid IncW R388 mating pair formation region. ACCESSION X81123 VERSION X81123.3 KEYWORDS eex gene; entry exclusion protein; korA gene; korB gene; ORF34; transcriptional repressor; trwD gene; trwE gene; trwF gene; trwG gene; trwH gene; trwI gene; trwJ gene; trwK gene; trwL gene; trwM gene; trwN gene. SOURCE Escherichia coli ORGANISM Escherichia coli Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. REFERENCE 1 AUTHORS Bolland S., Llosa M., de la Cruz F. TITLE Genetic organization of the region involved in conjugative pilus synthesis, export and assembly of the incW plasmid R388 JOURNAL J Biol Chem 272(41), 25583-25590(1997). PUBMED 9325277 REFERENCE 2 AUTHORS de la Cruz F. JOURNAL Submitted (19-AUG-1994) to the INSDC. F. de la Cruz, Dept de Biologia Molecular, Universidad de Cantabria, Herrera Oria s/n, 39011 Santander, SPAIN REMARK revised by [3] REFERENCE 3 AUTHORS de la Cruz F. JOURNAL Submitted (27-MAR-2002) to the INSDC. F. de la Cruz, Dept de Biologia Molecular, Universidad de Cantabria, Herrera Oria s/n, 39011 Santander, SPAIN REMARK revised by [4] REFERENCE 4 (bases 1 to 11453) AUTHORS de la Cruz F. JOURNAL Submitted (11-JUL-2002) to the INSDC. F. de la Cruz, Dept de Biologia Molecular, Universidad de Cantabria, Herrera Oria s/n, 39011 Santander, SPAIN FEATURES Location/Qualifiers source 1..11453 /organism="Escherichia coli" /plasmid="IncW R388" /strain="K-12" /mol_type="genomic DNA" /clone="pSU4058" /db_xref="taxon:562" CDS complement(142..1218) /transl_table=11 /gene="trwD" /product="TrwdD protein" /db_xref="GOA:O50338" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR014155" /db_xref="InterPro:IPR027417" /db_xref="UniProtKB/TrEMBL:O50338" /protein_id="CAA57032.1" /translation="MSTVSKASPLSSGNRVGKDQAVAQLLRPLDRFLDAPEVTELSIC RPGEVWTKTFEGWQVHEVPELTEPFLQALITAIIVYNGVAPKSVNYVVLPGGQRGTIA QAPAVIDGTLSFLIRKHSLVVKTLEELDAEGAFDTFTDVSFNKPSAEEANHYLTVQDF TRLEPFEVELLKLKRDGTIREFLEKCVLYKRNIIIAGKTGSGKTTFARSLIEKVPPEE RIITIEDVHELFLPNHPNRVHMLYGYGAGRVSADECLAACMRQSPDRIFLAELRGNEA WEYLNSLNTGHPGSITTTHANNALQTFERCATLIKKSDVGRQLEMEMIKLVLYTTIDV VLFFKDRKLVEVFYDPIFSKSKMA" CDS complement(1184..2371) /transl_table=11 /gene="trwE" /product="TrwE protein" /db_xref="GOA:O50337" /db_xref="InterPro:IPR005498" /db_xref="InterPro:IPR042217" /db_xref="UniProtKB/TrEMBL:O50337" /protein_id="CAA57031.1" /translation="MFGRKKGDVIDAGAELERAEQERIEGEYGASELASERRPHTPGA RTLLMVLLCVIAVVLVTLSYKAYKVRGVVEDDDAQPQQVVRQVIPGYTPRPIRPEPEN VPEPPQPTTSVPAIQPAPVTQPVRPQPTGPREKTPYELARERMLRSGLTAGSGGGEDL PRPQGGDVPAGGLMGGGGGGGELAEKLQPMRLSGSSAGRLGNRDMLITQGTQLDCVLE TRLVTTQPGMTTCHLTRDVYSTSGRVVLLDRGSKVVGFYQGGLRQGQARIFVQWSRIE TPSGVVINLDSPGTGPLGEAGLGGWIDRHFWERFGGAIMISLIGDLGDWASRQGSRQG NNSIQFSNTANGVESAAAEALRNSINIPPTLYKNQGERVNILVARDLDFSDVYSLESI PTK" regulatory 1227..1229 /note="RBS21" /regulatory_class="ribosome_binding_site" CDS complement(2371..3171) /transl_table=11 /gene="trwF" /product="TrwF protein" /db_xref="InterPro:IPR010258" /db_xref="InterPro:IPR033645" /db_xref="InterPro:IPR038161" /db_xref="UniProtKB/TrEMBL:O50336" /protein_id="CAA57030.1" /translation="MKKLAIVALLASLHAVPALALDVPSSSRYDHRIRYVTYNPADVV QVDTVLGVATHIMLEEGEQYLTHAFGIPKPMPLPGRAGIFLSSRTAELANTNLIVVTD RRSYKFRLQMRNDRNGAMYELAFRYPDTQARQTREANARAAVEAAFEQRVGAYYNLKY MMSGDKDIAPVNAWDDGRFTYFKFSANADLPSIYFVDAEGNESLVPRTTVGSSNNIIA VHKVNPKWMIRLGNRALAIFNEAYDPNGVPNDTGTASPAVRRVNKGGN" regulatory 2378..2382 /note="RBS22" /regulatory_class="ribosome_binding_site" regulatory 3180..3183 /note="RBS23" /regulatory_class="ribosome_binding_site" CDS complement(3182..3877) /transl_table=11 /gene="trwG" /product="TrwG protein" /db_xref="GOA:O50335" /db_xref="InterPro:IPR007430" /db_xref="InterPro:IPR026264" /db_xref="InterPro:IPR032710" /db_xref="UniProtKB/TrEMBL:O50335" /protein_id="CAA57029.1" /translation="MSKKQPKPVKAEQLKSYYEESRGLERDLIGEFVKSRKTAWRVAT ASGLFGLLGMVCGIVGFSQPAPAPLVLRVDNATGAVDVVTTLREHESSYGEVVDTYWL NQYVLNREAYDYNTIQMNYDTTALLSAPAVQQDYYKLFDGSNARDRVLGNKARITVRV RSIQPNGRGQATVRFTTQQHNSNGTVERPQHQIATIGYTYIGAPMRSSDRLLNPLGFQ VTSYRADPEILNN" CDS complement(3874..4017) /transl_table=11 /gene="trwH" /product="TrwH protein" /db_xref="UniProtKB/TrEMBL:O50334" /protein_id="CAA57028.1" /translation="MKTIIFAILMTGLLSACASAPKPKQPSDFNREPVNKTVPVEIQR GAL" regulatory 3884..3887 /note="RBS24" /regulatory_class="ribosome_binding_site" repeat_region 3989..4008 /note="Korbox4" regulatory 4025..4028 /note="RBS25" /regulatory_class="ribosome_binding_site" regulatory 4051..4056 /note="-10 Signal 4" /regulatory_class="minus_10_signal" repeat_region 4067..4086 /note="Korbox5" regulatory 4074..4079 /note="-35 Signal 4" /regulatory_class="minus_35_signal" CDS complement(4131..5159) /transl_table=11 /gene="trwI" /product="TrwI protein" /db_xref="GOA:O50333" /db_xref="InterPro:IPR007688" /db_xref="UniProtKB/TrEMBL:O50333" /protein_id="CAA57027.1" /translation="MAFELFTPLFNKIDQTTATYVTDISSRAIAAITPVVSVGLTLGF ITYGWLIIRGAVEMPVAEFLNRCLRIGIIVSIALAGGLYQGEIANAITTVPDELASAL LGNPTEGASAAALVDQSAQQGFDRASEAFEEAGFFSSDGLLYGLFGIIIPAGYGPAGA IGGAFLLLAKIALALLAGLGPLFILALIWQPTHRFFDQWAQQVLNYGLLIVLFAAVFG LLMQIFGSYMADLRFDGAQNVAYAIGGSVILSIVSIVLLMQLPSIASGLAGGIGLGYM WELRSMRSGAGAAMRGGRAMARGARAAPGAARGAAVGAANMAKTVATGGAGVARAAAG YFRGRKAG" regulatory 5166..5172 /note="RBS26" /regulatory_class="ribosome_binding_site" CDS complement(5173..5403) /transl_table=11 /gene="eex" /product="entry exclusion protein" /db_xref="UniProtKB/TrEMBL:O50332" /protein_id="CAA57026.1" /translation="MKKILVPLLMVSALSACKDEPTHDVQYYLDNPKERTEKIAECKN NPGEKALAANCVNATEAQRKAMFQGDGMPKIR" CDS complement(5400..6080) /transl_table=11 /gene="trwJ" /product="TrwJ protein" /db_xref="GOA:O50331" /db_xref="InterPro:IPR014158" /db_xref="InterPro:IPR023220" /db_xref="UniProtKB/TrEMBL:O50331" /protein_id="CAA57025.1" /translation="MKKLVMTAAVAAILGAASPVMAQGIPVFDGTRALDFVQQFARMK EQLDTAKDQLAEAQRMYEAVTGGRGLGDLMRNAQLREYLPDDLRTVYDSANGGGYSGI SGSINDILRDERLNGSVADMRRSIEERSRTARTTDKAVGCGPTKGHSNASRRLKDEIS RTQDQKAIEELQARIAGEQAAIQNETTKLQMIAQLRQAEQALISEQRRERNMPILSSG NQGMPTIQ" CDS complement(6077..8548) /transl_table=11 /gene="trwK" /product="TrwK protein" /db_xref="GOA:O50330" /db_xref="InterPro:IPR004346" /db_xref="InterPro:IPR018145" /db_xref="InterPro:IPR027417" /db_xref="UniProtKB/TrEMBL:O50330" /protein_id="CAA57024.2" /translation="MGAIESRKLLASETPVGQFIPYSHHVTDTIISTKNAEYLSVWKI DGRSHQSASEADVFQWIRELNNTLRGISSANLSLWTHIVRRRVYEYPDAEFDNVFCRQ LDEKYRESFTGYNLMVNDLYLTVVYRPVSDKVLSFFAKRERETPDQKKHRQESCIKAL EDINRTLGQSFKRYGAELLSVYEKGGHAFSAPLEFLARLVNGEHIPMPICRDRFSDYM AVNRPMFSKWGEVGELRSLTGLRRFGMLEIREYDDATEPGQLNVLLESDYEFVLTHSF SVLSRPAAKEYLQRHQKNLIDARDVATDQIEEIDEALNQLISGHFVMGEHHCTLTVYG ETVQQVRDNLAHASAAMLDVAVLPKPVDLALEAGYWAQLPANWQWRPRPAPITSLNFL SFSPFHNFMSGKPTGNPWGPAVTILKTVSGTPLYFNFHASKEEEDATDKRLLGNTMLI GQSSSGKTVLLGFLLAQAQKFKPTIVAFDKDRGMEISIRAMGGRYLPLKTGEPSGFNP FQLPPTHANLIFLKQFVKKLAAAGGEVTHRDEEEIDQAITAMMSDSIDKSLRRLSLLL QFLPNPRSDDMDARPTVHARLVKWCEGGDYGWLFDNPTDALDLSTHQIYGFDITEFLD NPEARTPVMMYLLYRTESMIDGRRFMYVFDEFWKPLQDEYFEDLAKNKQKTIRKQNGI FVFATQEPSDALESNIAKTLIQQCATYIFLANPKADYEDYTQGFKLTDSEFELVRGLG EFSRRFLIKQGDQSALAEMNLGKFRTIVDGETVERDFDDELLVLSGTPDNAEIAESII AEVGDDPAVWLPIFLDRVKAERSDV" regulatory 6087..6090 /note="RBS28" /regulatory_class="ribosome_binding_site" CDS complement(8551..8865) /transl_table=11 /gene="trwM" /product="TrwM protein" /db_xref="GOA:O50329" /db_xref="InterPro:IPR007792" /db_xref="UniProtKB/TrEMBL:O50329" /protein_id="CAA57023.1" /translation="MKPPQQQHEAFPLFKGATRLPTILGEPMIPLMAMVMGVAVIALT VSIWWWALVPPLWFIMAQITKNDDKAFRIWWLWIDTKFRNRNKGFWGASSYSPANYRK RR" regulatory 8555..8558 /note="RBS29" /regulatory_class="ribosome_binding_site" regulatory 8872..8876 /note="RBS30" /regulatory_class="ribosome_binding_site" CDS complement(8878..9216) /transl_table=11 /gene="trwL" /product="TrwL protein" /db_xref="GOA:O50328" /db_xref="InterPro:IPR007039" /db_xref="UniProtKB/TrEMBL:O50328" /protein_id="CAA57021.2" /translation="MATSILTRKTNMKNLNYLRAKANGKLAAIFGAIAAMLTAQPAAA QGLEKARSVLETLQQELTTIVPIAAAVILLCLGIAYAGRFIEKDTFVRWSIGVIIAGS AVQITAMLFT" CDS complement(9149..9445) /transl_table=11 /gene="korA" /product="putative transcriptional repressor" /db_xref="UniProtKB/TrEMBL:Q8KMU8" /protein_id="CAD42328.1" /translation="MRAIEQQSVDKAFSQRAVREVTVVKRSEKEWYFTFVADDPVTKK PVTYALLTQRGKLRTWADPRHLFNFLRERGVTHGNFNLDEENKHEEPELPPGES" regulatory 9225..9228 /note="RBS31" /regulatory_class="ribosome_binding_site" regulatory 9456..9458 /note="RBS32" /regulatory_class="ribosome_binding_site" regulatory 9511..9516 /note="-10 Signal 3" /regulatory_class="minus_10_signal" regulatory 9534..9539 /note="-35 Signal 3" /regulatory_class="minus_35_signal" repeat_region 9535..9554 /note="Korbox2" repeat_region 9558..9577 /note="Korbox3" CDS complement(9670..10266) /transl_table=11 /gene="trwN" /product="TrwN protein" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="UniProtKB/TrEMBL:Q8KMV0" /protein_id="CAD42326.1" /translation="MALAEFAVIAAMCAPAIHPTTLSAVVTQESRGNIYAIGINGDHK LPRQPQTLEEAIATAEQLRRDGYNFDAGLGQINIKNLEWLGMSIADLFDPCKNLKGAQ TVLLDCYERAVPRYGDGQGALQAALSCYNTGNFQRGFSNGYVQKVASHVGVTVPALEP VSGGTQEPAKLQAVPKGAARLAPAQTKATGRACRCLLS" CDS complement(10268..10861) /transl_table=11 /product="hypothetical protein" /note="ORF34" /db_xref="UniProtKB/TrEMBL:Q8KMU7" /protein_id="CAD42329.1" /translation="MNRKMTVVSASLVGALSLFSQTAKADDWGCQVLLCLSDPRGPTT ESECKPPIHKLWDHLRKGKPFPSCAMATNSRTGKRSYAQLVYDPYDPCPDGTKPAGGY IAQSQSADRKDWRRLQYAFSTHGRRYDSGGAWNMYEGNGPRACVGNHLGSYSVYRGND DSNISVQVYDQVVWQQPQNPRAIDVFIDEAFHHRVRY" regulatory 10278..10280 /note="RBS33" /regulatory_class="ribosome_binding_site" regulatory 10869..10875 /note="RBS34" /regulatory_class="ribosome_binding_site" regulatory 10889..10894 /note="-35 Signal 2" /regulatory_class="minus_35_signal" repeat_region 10891..10910 /note="Korbox1" regulatory 10912..10917 /note="-10 Signal 1" /regulatory_class="minus_10_signal" regulatory 10913..10918 /note="-10 Signal 2" /regulatory_class="minus_10_signal" regulatory 10936..10941 /note="-35 Signal 1" /regulatory_class="minus_35_signal" regulatory 10985..10988 /note="RBS35" /regulatory_class="ribosome_binding_site" CDS 10998..11285 /transl_table=11 /gene="korB" /product="putative transcriptional repressor" /db_xref="GOA:Q8KMU9" /db_xref="InterPro:IPR001801" /db_xref="InterPro:IPR027444" /db_xref="InterPro:IPR037150" /db_xref="UniProtKB/TrEMBL:Q8KMU9" /protein_id="CAD42327.1" /translation="MNDLKNMSADELRAQRAQIDAELKKREAKERQEARKKILEIANT HGINIAELASKERQYRNPDDQWETWNGRGRKPKWVKEWLAKGHSLEELEVS" BASE COUNT 2486 a 3320 c 3132 g 2515 t ORIGIN 1 cgcatgatcg gcagaaggcc gccagagaag ccgagcgcgg catggaggcc ggaaggtaag 61 cagggacaag aaaaagcccg tagcgcgtgc tacgggcttt cttgccggtt ccccgataca 121 gccgagggga ggggagggcg gctaagccat cttggacttg gaaaagatcg ggtcatagaa 181 cacttcgacc agcttccgat ctttgaagaa cagcacaacg tcaattgtcg tgtagagcac 241 cagctttatc atttccattt cgagctgacg gcccacatcg gatttcttga tgagtgtggc 301 gcaccgctcg aatgtctgca aagcattgtt cgcgtgcgtc gtcgtgatcg agccgggatg 361 cccggtgttc agtgaattga ggtattccca agcctcattg ccgcgcagct cggccagaaa 421 gatgcggtcg ggtgactggc gcatacacgc ggccaagcac tcgtcggccg acacccggcc 481 cgcaccgtag ccatagagca tgtgaacccg gttcggatgg ttcggcaaga aaagctcgtg 541 cacatcttca atcgtgatga tgcgttcctc gggcggcact ttttcaatca acgaccgggc 601 aaacgtggtt ttgcccgagc cggtcttgcc cgcgatgatg atgttgcgct tgtagagcac 661 gcacttttcg agaaattcgc ggatagtgcc gtcgcgcttg agcttcaata gctcaacctc 721 gaacggctcc aatcgcgtga agtcctgcac cgtcagatag tggttcgctt cttcggccga 781 gggcttgtta aagctcacat cggtaaaggt atcgaacgcg ccttccgcat cgagttcttc 841 cagtgtcttg acgacaaggg agtgtttgcg gatgaggaaa gacagcgtgc cgtcaatcac 901 ggcgggcgct tgcgcgatcg ttccacgctg cccgccggga agtacaacat agttgacgct 961 ttttggagcc accccgttat aaacgatgat ggccgtgata agcgcctgca agaagggttc 1021 ggtaagctcc ggcacctcat gcacctgcca gccttcaaag gtttttgtcc aaacctctcc 1081 agggcggcaa atggacagtt ccgtaacctc cggcgcatcg agaaaccgat caagcgggcg 1141 caggagttgc gccacggcct gatctttccc gacgcggttc ccgctactta gtggggatgc 1201 tttcgagact gtagacatcg ctgaaatcca gatcacgggc gacgaggata ttcacccgct 1261 cgccttggtt tttatacaga gtgggcggaa tgttgatcga gttgcgcaga gcttccgcag 1321 cagccgattc caccccgttc gcagtgttgg aaaactggat agagttattg ccttggcgac 1381 tgccttgacg gcttgcccaa tcgcccaaat caccgatcaa gctaatcatg atggcaccgc 1441 cgaaacgctc ccaaaaatgc cgatcaatcc agccacccaa accagcttcg ccaagcgggc 1501 cagtaccggg agaatctagg ttgatgacga caccggaggg cgtttcaatc cgcgaccact 1561 gcacaaagat tcgcgcttgg ccttgccgca gcccgccttg atagaacccg acgactttag 1621 agccacgatc aagcagcact acgcggccac tggtcgagta aacgtcccgc gtcagatggc 1681 aggtagtcat gccgggttgc gtcgtcacaa ggcgcgtttc aagcacgcaa tcgagctgcg 1741 ttccctgcgt tatcagcatg tcacggttgc caaggcggcc agcacttgaa cccgaaaggc 1801 gcatcggttg cagcttttcg gccagctcac cgccgccacc accgccaccc atcagaccac 1861 cggcaggcac atcgccgcct tgcggccgag gaagatcctc accgccaccg ctgcccgccg 1921 tcaggccaga gcgcaacatg cgttcgcggg ccagctcata gggcgttttt tcacgcgggc 1981 cggtcggttg cgggcgcact ggctgcgtta ccggcgcggg ctgaatcgct ggaaccgatg 2041 tagtcggttg cggcggttca ggtacgtttt ccggctcggg tcggattgga cgcggcgtat 2101 aacccggaat gacttggcgc acgacctgtt gcggctgcgc gtcgtcatcc tcgacaaccc 2161 cgcgcacttt gtacgccttg tatgagagcg tcaccagcac cacggcaatc acgcacagca 2221 gcaccataag cagcgtgcga gcaccgggag tatgcgggcg acgttccgaa gccagctcgg 2281 aagcgccata ttcgccctcg atacgttcct gctcggcgcg ttccagttcc gcgcccgcgt 2341 cgattacgtc tcctttcttg cgaccgaaca ttagttgcct cctttgttga cgcgacgaac 2401 cgccggggag gctgtgccag tgtcattcgg cacaccattg gggtcatacg cttcattgaa 2461 gatcgccaag gcgcggttac caagtcgaat catccacttg ggattgacct tgtgaacggc 2521 aatgatgttg ttggacgagc caaccgtagt gcgcggcaca aggctttcat tgccttccgc 2581 atccacaaag tagatcgacg gcaaatcggc attggcagag aacttgaagt aggtgaaacg 2641 cccatcatcc caagcgttga ccggcgcaat gtccttgtcg ccgctcatca tgtatttgag 2701 gttgtaatag gcccctacac gttgctcgaa tgcagcctcg acagcggccc gtgcgttcgc 2761 ttcccgagtt tgccgggcct gcgtatcggg ataacggaaa gccagctcat acatggcccc 2821 attgcggtca ttccgcattt gcaaacggaa tttgtagctg cgtcggtcag tcacgacgat 2881 gaggttggta ttggctagct cggccgtgcg gcttgataaa aatatgcccg cccttccggg 2941 caaaggcata ggcttcggaa tcccaaaggc atgcgtcaga tattgctcac cttcctcaag 3001 catgatgtgt gttgcgacac caagaacggt atcgacctgc accacatcag ccgggttgta 3061 cgtcacgtat cgaatccgat ggtcgtaacg cgagctggac ggcacatcga gggccaaagc 3121 gggcaccgca tgaagcgagg ccagcaatgc aacgatagct agtttcttca tggtgccccc 3181 ctcagttatt gagtatttcc gggtcagcgc gatagcttgt gacctggaaa ccaagagggt 3241 taagcaaccg atcagatgaa cgcatcggcg caccgatgta ggtatagcca atcgtcgcta 3301 tctgatgttg cggacgttcg accgtgccat tgctgttgtg ctgttgcgtc gtaaagcgca 3361 ccgtcgcttg gccgcggcca ttaggttgga tggagcgcac ccgaacggta atgcgggctt 3421 tgttccccaa gacccgatca cgcgcattcg agccgtcaaa gagcttgtag taatcctgct 3481 gaaccgccgg ggcgctcaat agcgccgtcg tgtcatagtt catttggatt gtgttgtagt 3541 cgtaggcttc gcgattgagc acgtactgat tgagccagta cgtatcgacc acttcgccat 3601 agctggactc atgctcgcgc agcgtcgtca ccacatcgac ggcacccgtg gcgttatcca 3661 cccgaagcac caagggcgcg ggagccggtt gggagaaccc gacaattcca cacaccatgc 3721 caagcaggcc gaaaaggccg ctcgccgttg ccacccgcca agcggtcttg cgcgatttga 3781 cgaactcgcc aatcaaatcc cgttccaagc cacggctttc ctcatagtag cttttgagct 3841 gttctgcctt gaccggtttt ggttgcttct tgctcatagt gcccctcgct gaatttccac 3901 gggcaccgtc ttgttgaccg gctcccggtt gaaatcactc ggctgcttcg gcttgggagc 3961 cgatgcacac gccgacaata gccccgtcat caaaattgca aaaatgatgg ttttcacgtc 4021 aacacctctc ctttctcggc tgtagaaccg agtctaacag tttcgtatca ggattgcaat 4081 tttgatgtgt aaaggggcgg gtataaaacc gccgctttac accctgacaa ctaccctgct 4141 ttgcgtcccc ggaagtaacc ggcggctgcc cgtgctacac cggcgccgcc ggtagcaacg 4201 gttttcgcca tattggcggc accaaccgcc gcgccacgtg ctgcaccggg cgcagctctt 4261 gccccacggg ccatagcgcg gccaccacgc atagcggcac ccgcaccgct gcgcatcgag 4321 cgcaattccc acatatagcc aaggccaatg ccaccggcta acccgctggc aatgcttggc 4381 aattgcatca gcagcacgat ggagacaatc gagaggatga cggagccgcc aatcgcgtag 4441 gcgacgtttt gcgcgccatc aaaccgcaga tcggccatgt aactcccgaa tatctgcatc 4501 agcagcccga acacagccgc aaagagcaca atcagcaggc catagttcaa aacctgttgt 4561 gcccattgat cgaaaaagcg gtgcgtcggc tgccagatca gggcgaggat aaacagcggc 4621 ccaagccctg ccagcagagc aagggcaatc ttcgcaagaa gcaaaaacgc gccgcctatc 4681 gcgccagcag gcccgtagcc agcaggaatg atgatgccga acaatccata gagcaggccg 4741 tcagagctga agaaccccgc ttcctcaaac gcctcgcttg cccggtcaaa cccttgttgc 4801 gccgactggt caaccaacgc ggccgccgac gccccttctg tcggatttcc gagcagggcc 4861 gaagccagct catccggcac cgtggtaatg gcattagcga tttcgccttg atacaaacca 4921 ccggccaggg caattgacac gatgatgcct attcgtaggc agcggttgag aaattccgcc 4981 accggcattt ccaccgcgcc ccgaataatg agccagccat aggtaatgaa gccaagggtc 5041 aaacccaccg aaacaaccgg cgtgatagca gcgattgccc gcgaggaaat gtccgtgaca 5101 tacgttgccg ttgtctggtc aatcttgttg aaaagcggtg tgaacagctc gaaggccacg 5161 gcaatttcct ccctaccgga tttttggcat cccgtcgcct tggaacatgg ccttgcgctg 5221 cgcttcggtt gcgttcacgc agtttgctgc aagggctttt tcaccgggat tgttcttgca 5281 ctcggcaatt ttctcggtgc gttccttggg gttgtcgaga tagtattgaa cgtcatgcgt 5341 cggctcgtcc ttgcaagcgg acagagccga caccatcaac aggggtacga gtatcttttt 5401 cattggatag tcggcattcc ttggtttcca ctactcagga tcggcatgtt gcgctcgcgt 5461 cgttgctccg aaatcaacgc ctgttctgct tgccgcagtt gcgcgatcat ttgcagcttc 5521 gtcgtttcgt tctggatagc ggcttgctcg cccgcgatac gggcttgcaa ttcttcaatg 5581 gccttttggt cttgggtacg gctaatttca tccttcaatc tgcgtgaggc gttgctgtgc 5641 cccttcgtag gcccgcagcc aacggccttg tcggttgtcc gcgccgtgcg gctacgttcc 5701 tcgatagagc ggcgcatatc ggccacggag ccgttaaggc gctcatcccg cagaatgtca 5761 ttgatcgagc cagaaatgcc cgaatacccg ccaccattgg ccgagtcata gacagtgcgc 5821 aaatcatccg gcagatattc gcggagttgc gcattgcgca tcaaatcccc aagaccacgg 5881 ccacccgtga cggcctcata catgcgctgc gcttcggcga gctgatcttt ggccgtgtcg 5941 agctgttctt tcatgcgggc aaactgttgg acaaaatcta gtgcccgcgt gccgtcgaaa 6001 acaggaatac cctgggccat tacagggctt gccgccccaa gaatggcggc caccgccgcc 6061 gtcataacca gcttcttcat acgtcgctcc tttcggcttt cacacggtct aggaagatcg 6121 gcaaccacac cgccgggtcg tctccgactt cggcaataat gctttcggca atttcggcat 6181 tgtctggcgt gcccgacagc acaagcagct catcatcaaa gtcacgctcg accgtctcac 6241 catcgacaat cgtgcggaac ttaccgagat tcatttcggc aagcgccgat tggtcgccct 6301 gctttatcag gaaccggcgg ctgaactcac caaggccccg aacaagctca aattccgagt 6361 cagtcagctt gaaaccttgc gtgtaatcct cgtaatccgc cttggggtta gcgaggaaaa 6421 tgtaggtcgc gcattgctga atgagcgtct tggcaatgtt gctttccaag gcgtcgctcg 6481 gctcctgcgt ggcgaataca aagatgccgt tttgcttacg gatggtcttt tgcttgttct 6541 ttgccaaatc ctcgaaatac tcgtcctgca agggcttcca gaactcgtca aacacgtaca 6601 tgaaccggcg accgtcgatc atgctttccg tgcgatacag caggtacatc atgaccggtg 6661 tacgcgcttc ggggttgtcc aagaactcgg taatgtcgaa cccgtaaatt tggtgcgttg 6721 atagatcgag ggcatcagtc gggttgtcga acagccagcc ataatcgcca ccctcgcacc 6781 acttcaccaa tcgcgcatgg acggtcgggc gagcgtccat gtcgtccgag cgcgggttag 6841 gcaggaattg cagcagcaac gacaagcgcc gtagcgactt gtcgatactg tcactcatca 6901 ttgccgtaat ggcctggtcg atttcttcct cgtcccggtg cgtgacctcg ccaccggcag 6961 ccgcgagctt cttcacgaac tgtttgagga aaatcaggtt tgcgtgcgtc ggcgggagct 7021 gaaacgggtt gaacccgctt ggctcgccgg ttttaagcgg cagataccgg ccacccattg 7081 ccctgatcga gatttccatg ccgcgatctt tgtcaaaggc aacaatcgtc ggcttgaatt 7141 tttgcgcttg ggccagcagg aagccgagca gcaccgtttt accggagctt gattgcccga 7201 tgagcatggt gttaccgagc aggcgcttat cggtcgcatc ttcttcttcc ttggaggcgt 7261 ggaagttgaa gtagagcggc gttccgctca cggtcttgag aatcgtgacc gcaggccccc 7321 aagggtttcc agtcggcttg cccgacatga aattatggaa gggcgaaaac gacaggaagt 7381 taagcgacgt gatcggagct ggacgcggcc gccattgcca gttagcaggc agttgcgccc 7441 aatatcccgc ttccaaagcc agatcgaccg gcttgggcag cacagccaca tcaagcatgg 7501 cagcgctcgc gtgcgccaag ttatcgcgca cttgctgcac cgtctcaccg taaaccgtca 7561 gggtgcaatg atgctcgccc atgacgaaat gcccactgat gagctggttc agggcttcgt 7621 caatttcctc aatctgatcg gttgccacat cacgggcatc aatcaggttc ttttggtgcc 7681 gctgcaaata ttccttcgcg gcaggccgcg acagaaccga gaaactatgc gtcagcacaa 7741 attcgtaatc actttccagc aatacattga gttggccggg ttcggtcgcg tcgtcgtact 7801 cgcggatttc cagcatcccg aagcggcgca ggccggtaag ggaacgcagc tcccctactt 7861 cgccccactt cgagaacatg ggccgattca cggccatgta atccgaaaaa cggtcgcggc 7921 aaatcggcat ggggatatgc tcgccattga ccaagcgggc cagaaattct agcggcgctg 7981 aaaaggcatg gccgcccttt tcatagacac taagcagctc ggccccgtac cgtttgaatg 8041 actggcccaa ggtacggttt atgtcctcca atgccttgat gcaggactct tgccgatgct 8101 tcttttggtc gggcgtttcg cgctcccgct tggcaaagaa cgacaacacc ttgtcggaca 8161 caggccggta aacaaccgtc agatagaggt cattcaccat caggttatag ccggtgaagc 8221 tctcccggta tttctcatcg agttgacggc aaaacacgtt gtcaaactcg gcatcggggt 8281 actcatagac gcggcggcgc acgatgtgcg tccatagcga caggttcgcc gaggaaatac 8341 cgcgcagtgt attgttcagc tcccgaatcc actggaaaac atcagcctcc gaggcgcttt 8401 gatgggaacg gccgtcaatc ttccaaaccg acaggtattc cgcgtttttc gtggaaatga 8461 tcgtgtcagt aacgtggtgc gagtatggaa tgaactggcc taccggcgtc tccgaagcca 8521 ggagcttgcg ggattcaatt gcccccatgc ctatctcctt tttcggtagt tagcggggct 8581 atacgacgat gcgccccaaa agcccttgtt gcggttgcgg aacttggtat caatccacaa 8641 ccaccagata cggaacgcct tgtcgtcgtt cttcgtgatt tgggccatga tgaaccacag 8701 cggcggcaca agcgcccacc accagatgct gaccgtcaac gctatgacgg ccacgcccat 8761 gaccattgcc attagcggaa tcatcggctc gcccaaaatc gttggaagtc gcgttgcccc 8821 cttgaacagg gggaacgctt cgtgctgctg ctgtggcggc ttcatgactg tcccccttta 8881 ggtaaacagc atggccgtaa tctggacggc ggaaccggca atgatgacgc cgatagacca 8941 ccgcacaaac gtatcctttt cgatgaatcg gcccgcgtat gcgatgccga ggcagagcag 9001 gatgacagcg gccgcaatgg gcacaatcgt cgtaagttcc tgctgcaatg tttcgaggac 9061 gctcctcgcc ttttccaatc cttgagccgc cgccggttga gcggtgagca tggccgctat 9121 tgctccaaaa atcgcggcca gctttccgtt agctttcgcc cggaggtagt tcaggttctt 9181 catgtttgtt ttcctcgtca agattgaagt tgccatgagt aacgcccctt tcgcgcagaa 9241 aattaaaaag gtgtcttggg tcagcccaag ttctcaattt gccccgttga gtaagaagcg 9301 cgtaggtgac tggctttttt gtcaccggat catccgcaac aaacgtgaag taccattcct 9361 tttccgaacg cttcacgact gttacttcgc gcacagccct ttgactaaag gctttatcaa 9421 cgctttgctg ttctatagct ctcattttgg ttggcccttg atcgcatgtt taatcgtttc 9481 aagtttatca gtcagggcct aaaattctcc attgaatttc gaccaccgta ttatatcaaa 9541 attgcaatct tgatgctatc aaattttcaa ttttgatcaa cggcggcagt tgccttcacc 9601 tccttttctt cttcttcatt ctccgaaaag gcgtcgcttg cattaaatgc gtcacgtaca 9661 ccgctcgcct catgagagaa ggcatctgca agcccttccc gtggccttcg tttgtgccgg 9721 agctaaacgc gccgcaccct tgggcaccgc ttgcagcttg gccggttctt gtgtcccacc 9781 agataccggc tcaagcgcag gcaccgttac gccaacatga gaagccactt tctgcacata 9841 gccattggag aatccgcgct ggaaattgcc cgtgttgtag cagctcaaag ccgcctgcaa 9901 tgcgccctgg ccgtcgccgt atcgcggcac tgccctttcg tagcagtcga gcaatacggt 9961 ttgcgcccct ttcaggttct tgcacgggtc gaacaggtcg gcgatagaca tgccgagcca 10021 ttccagattt ttgatgttga tctgaccgag gcccgcatcg aagttgtacc catcacggcg 10081 gagctgttcg gcggtcgcaa tggcttcttc aagcgtttgc ggctgacgcg gcaatttgtg 10141 atcgccgtta atcccgatgg cgtagatatt gccccgagat tcttgcgtca caaccgccga 10201 aagcgttgtc ggatggatag cgggcgcgca catggcagcg atcaccgcga actctgccag 10261 tgccatatca gtaccgcacc cgatgatgga atgcttcgtc tatgaaaacg tcgatagctc 10321 gtgggttttg tggctgttgc cacacaactt ggtcatagac ttgtaccgag atgttgctgt 10381 cgtcattgcc ccgatagacc gaatagctgc caaggtgatt gccgacgcag gcacgtggcc 10441 cattaccttc gtacatattc catgccccgc cgctatcgta gcgacggcca tgcgtggaga 10501 aggcatattg gagccgacgc cagtctttac ggtcggccga ttgagattgc gcgatatatc 10561 cccctgctgg cttcgtgccg tccgggcacg ggtcataggg gtcatatacc aactgcgcat 10621 aactgcgttt tccagtgcgc gagttggtcg ccatagcgca gctcgggaac ggcttgccct 10681 ttcgcaagtg atcccacagc ttatggattg gcggtttgca ttcgctttcc gtggttggcc 10741 cacgcgggtc tgacaggcac aatagaacct gacaacccca gtcatcagcc tttgcagttt 10801 gactgaaaag tgacaatgca cctacaagag aggctgaaac gacggtcatt tttcggttca 10861 cggtgtaacc tccttgggag tgagatagtt gtcaaaattg caattttgat tgatgatgac 10921 aggaaggccg aaggctgtca agcaatacgg tcgcaatctg accatccgca attctagtgt 10981 agaaggagag tagaaaagtg aatgacctca agaacatgag cgccgacgag ctgcgtgcac 11041 agcgtgccca gatcgacgca gaactcaaga aacgagaggc caaagagagg caggaagccc 11101 gcaagaaaat tctcgaaatt gccaacacgc atggaataaa catcgccgag cttgcgagca 11161 aggaacgtca gtatcgtaat cctgacgacc aatgggaaac atggaacgga cgcgggcgca 11221 agcccaaatg ggtcaaagaa tggctcgcca aggggcactc gctcgaagaa ctggaagtat 11281 catgaattga agatcgggcc gtaaggccag gaggaacact atggaacccc accgcaccaa 11341 cgtcattatt tttccgaagg tgcgcgaagt cgcagaggcg gccgagcaag cctgacaggc 11401 ccgaaaagcc cggcacgggc gtcggcggcg atgacggcgg cggcattatc cag //