LOCUS       X65019                  1358 bp    mRNA    linear   HUM 02-JUL-1992
DEFINITION  H.sapiens mRNA for interleukin-1B converting enzyme.
ACCESSION   X65019
VERSION     X65019.1
KEYWORDS    interleukin-1B converting enzyme.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1358)
  AUTHORS   Thornberry et al.
  TITLE     Interleukin-1B converting enzyme:  a heterrodimeric cysteine
            protease required for processing of the IL-1B precursor in human
            blood monocytes
  JOURNAL   Nature 0, 0(0).
REFERENCE   2  (bases 1 to 1358)
  AUTHORS   Tocci M.
  JOURNAL   Submitted (27-FEB-1992) to the INSDC. M. Tocci, Merck, Sharp and
            Dohme Research Lab, 126 E. Lincoln Avenue, R80W-183, Rahway, NJ
            07065, USA
FEATURES             Location/Qualifiers
     source          1..1358
                     /db_xref="H-InvDB:HIT000322733"
                     /organism="Homo sapiens"
                     /isolate="1 year old male"
                     /mol_type="mRNA"
                     /clone_lib="lambda gt10"
                     /cell_line="THP.1 - acute monocytic leukemia"
                     /db_xref="taxon:9606"
     CDS             8..1222
                     /product="interleukin-1B converting enzyme"
                     /note="subunit structure p20 1 p10 1"
                     /db_xref="GOA:P29466"
                     /db_xref="H-InvDB:HIT000322733.13"
                     /db_xref="HGNC:HGNC:1499"
                     /db_xref="InterPro:IPR001309"
                     /db_xref="InterPro:IPR001315"
                     /db_xref="InterPro:IPR002138"
                     /db_xref="InterPro:IPR002398"
                     /db_xref="InterPro:IPR011029"
                     /db_xref="InterPro:IPR015917"
                     /db_xref="InterPro:IPR016129"
                     /db_xref="InterPro:IPR029030"
                     /db_xref="InterPro:IPR033139"
                     /db_xref="PDB:1BMQ"
                     /db_xref="PDB:1IBC"
                     /db_xref="PDB:1ICE"
                     /db_xref="PDB:1RWK"
                     /db_xref="PDB:1RWM"
                     /db_xref="PDB:1RWN"
                     /db_xref="PDB:1RWO"
                     /db_xref="PDB:1RWP"
                     /db_xref="PDB:1RWV"
                     /db_xref="PDB:1RWW"
                     /db_xref="PDB:1RWX"
                     /db_xref="PDB:1SC1"
                     /db_xref="PDB:1SC3"
                     /db_xref="PDB:1SC4"
                     /db_xref="PDB:2FQQ"
                     /db_xref="PDB:2H48"
                     /db_xref="PDB:2H4W"
                     /db_xref="PDB:2H4Y"
                     /db_xref="PDB:2H51"
                     /db_xref="PDB:2H54"
                     /db_xref="PDB:2HBQ"
                     /db_xref="PDB:2HBR"
                     /db_xref="PDB:2HBY"
                     /db_xref="PDB:2HBZ"
                     /db_xref="PDB:3D6F"
                     /db_xref="PDB:3D6H"
                     /db_xref="PDB:3D6M"
                     /db_xref="PDB:3E4C"
                     /db_xref="PDB:3NS7"
                     /db_xref="PDB:5FNA"
                     /db_xref="PDB:5MMV"
                     /db_xref="PDB:5MTK"
                     /db_xref="PDB:6BZ9"
                     /db_xref="PDB:6F6R"
                     /db_xref="UniProtKB/Swiss-Prot:P29466"
                     /protein_id="CAA46153.1"
                     /translation="MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVK
                     RENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQ
                     DSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSS
                     RTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAF
                     AHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDK
                     PKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSST
                     PDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERV
                     TLTRCFYLFPGH"
BASE COUNT          435 a          270 c          314 g          339 t
ORIGIN      
        1 aaaagccatg gccgacaagg tcctgaagga gaagagaaag ctgtttatcc gttccatggg
       61 tgaaggtaca ataaatggct tactggatga attattacag acaagggtgc tgaacaagga
      121 agagatggag aaagtaaaac gtgaaaatgc tacagttatg gataagaccc gagctttgat
      181 tgactccgtt attccgaaag gggcacaggc atgccaaatt tgcatcacat acatttgtga
      241 agaagacagt tacctggcag ggacgctggg actctcagca gatcaaacat ctggaaatta
      301 ccttaatatg caagactctc aaggagtact ttcttccttt ccagctcctc aggcagtgca
      361 ggacaaccca gctatgccca catcctcagg ctcagaaggg aatgtcaagc tttgctccct
      421 agaagaagct caaaggatat ggaaacaaaa gtcggcagag atttatccaa taatggacaa
      481 gtcaagccgc acacgtcttg ctctcattat ctgcaatgaa gaatttgaca gtattcctag
      541 aagaactgga gctgaggttg acatcacagg catgacaatg ctgctacaaa atctggggta
      601 cagcgtagat gtgaaaaaaa atctcactgc ttcggacatg actacagagc tggaggcatt
      661 tgcacaccgc ccagagcaca agacctctga cagcacgttc ctggtgttca tgtctcatgg
      721 tattcgggaa ggcatttgtg ggaagaaaca ctctgagcaa gtcccagata tactacaact
      781 caatgcaatc tttaacatgt tgaataccaa gaactgccca agtttgaagg acaaaccgaa
      841 ggtgatcatc atccaggcct gccgtggtga cagccctggt gtggtgtggt ttaaagattc
      901 agtaggagtt tctggaaacc tatctttacc aactacagaa gagtttgagg atgatgctat
      961 taagaaagcc cacatagaga aggattttat cgctttctgc tcttccacac cagataatgt
     1021 ttcttggaga catcccacaa tgggctctgt ttttattgga agactcattg aacatatgca
     1081 agaatatgcc tgttcctgtg atgtggagga aattttccgc aaggttcgat tttcatttga
     1141 gcagccagat ggtagagcgc agatgcccac cactgaaaga gtgactttga caagatgttt
     1201 ctacctcttc ccaggacatt aaaataagga aactgtatga atgtctgtgg gcagggtgaa
     1261 gagatccttc tgtaaaggtt tttgaattat gtctgctgaa taataaactt ttttgaaata
     1321 ataaatctgg tagaaaaatg aaaaaaaaaa aaaaaaaa
//