LOCUS       X63598                  2471 bp    DNA     linear   BCT 18-APR-2005
DEFINITION  S.aureus mecR1 and mecI genes.
ACCESSION   X63598 S90543
VERSION     X63598.1
KEYWORDS    mecI gene; mecR1 gene; methicillin resistance; regulator region.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 2471)
  AUTHORS   Hiramatsu K.
  JOURNAL   Submitted (27-DEC-1991) to the INSDC. K. Hiramatsu, Dept of
            Bacteriology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo
            113, JAPAN
REFERENCE   2  (bases 1 to 2471)
  AUTHORS   Hiramatsu K., Asada K., Suzuki E., Okonagi K., Yokota T.
  TITLE     Molecular cloning and nucleotide sequence determination of the
            regulator region of mecA gene in methicillin-resistant
            Staphylococcus aureus (MRSA)
  JOURNAL   FEBS Lett. 298(2-3), 133-136(1992).
   PUBMED   1544435
FEATURES             Location/Qualifiers
     source          1..2471
                     /organism="Staphylococcus aureus"
                     /strain="Methicillin resistant, N315"
                     /mol_type="genomic DNA"
                     /clone="pES1"
                     /cell_line="N315"
                     /db_xref="taxon:1280"
     CDS             complement(<1..125)
                     /transl_table=11
                     /gene="mecA"
                     /db_xref="GOA:Q6LBL3"
                     /db_xref="UniProtKB/TrEMBL:Q6LBL3"
                     /protein_id="CAA45141.1"
                     /translation="MKKIKIVPLILIVVVVGFGIYFYASKDKEINNTIDAIEDKN"
     regulatory      complement(131..136)
                     /regulatory_class="ribosome_binding_site"
     regulatory      complement(157..162)
                     /regulatory_class="TATA_box"
     regulatory      163..168
                     /note="mecR1"
                     /regulatory_class="minus_35_signal"
     regulatory      complement(181..186)
                     /note="mecA"
                     /regulatory_class="minus_35_signal"
     regulatory      195..200
                     /regulatory_class="TATA_box"
     regulatory      212..218
                     /regulatory_class="ribosome_binding_site"
     CDS             225..1982
                     /transl_table=11
                     /gene="mecR1"
                     /db_xref="GOA:P0A0B0"
                     /db_xref="InterPro:IPR001460"
                     /db_xref="InterPro:IPR008756"
                     /db_xref="InterPro:IPR012338"
                     /db_xref="PDB:2IWB"
                     /db_xref="PDB:2IWC"
                     /db_xref="PDB:2IWD"
                     /db_xref="UniProtKB/Swiss-Prot:P0A0B0"
                     /protein_id="CAA45142.1"
                     /translation="MLSSFLMLSIISSLLTICVIFLVRMLYIKYTQNIMSHKIWLLVL
                     VSTLIPLIPFYKISNFTFSKDMMNRNVSDTTSSVSHMLDGQQSSVTKDLAINVNQFET
                     SNITYMILLIWVFGSLLCLFYMIKAFRQIDVIKSSSLESSYLNERLKVCQSKMQFYKK
                     HITISYSSNIDNPMVFGLVKSQIVLPTVVVETMNDKEIEYIILHELSHVKSHDLIFNQ
                     LYVVFKMIFWFNPALYISKTMMDNDCEKVCDRNVLKILNRHEHIRYGESILKCSILKS
                     QHINNVAAQYLLGFNSNIKERVKYIALYDSMPKPNRNKRIVAYIVCSISLLIQAPLLS
                     AHVQQDKYETNVSYKKLNQLAPYFKGFDGSFVLYNEREQAYSIYNEPESKQRYSPNST
                     YKIYLALMAFDQNLLSLNHTEQQWDKHQYPFKEWNQDQNLNSSMKYSVNWYYENLNKH
                     LRQDEVKSYLDLIEYGNEEISGNENYWNESSLKISAIEQVNLLKNMKQHNMHFDNKAI
                     EKVENSMTLKQKDTYKYVGKTGTGIVNHKEANGWFVGYVETKDNTYYFATHLKGEDNA
                     NGEKAQQISERILKEMELI"
     regulatory      1970..1973
                     /regulatory_class="ribosome_binding_site"
     CDS             1982..2353
                     /transl_table=11
                     /gene="mecI"
                     /db_xref="GOA:P68261"
                     /db_xref="InterPro:IPR005650"
                     /db_xref="InterPro:IPR036388"
                     /db_xref="InterPro:IPR036390"
                     /db_xref="PDB:1OKR"
                     /db_xref="PDB:1SAX"
                     /db_xref="PDB:1SD6"
                     /db_xref="PDB:1SD7"
                     /db_xref="PDB:2D45"
                     /db_xref="UniProtKB/Swiss-Prot:P68261"
                     /protein_id="CAA45143.1"
                     /translation="MDNKTYEISSAEWEVMNIIWMKKYASANNIIEEIQMQKDWSPKT
                     IRTLITRLYKKGFIDRKKDNKIFQYYSLVEESDIKYKTSKNFINKVYKGGFNSLVLNF
                     VEKEDLSQDEIEELRNILNKK"
BASE COUNT          975 a          312 c          376 g          808 t
ORIGIN      
        1 aaatttttat cttcaattgc atcaatagta ttattaattt ctttatcttt ggaagcataa
       61 aaatatatac caaacccgac aactacaact attaaaataa gtggaacaat ttttatcttt
      121 ttcatcaata tcctccttat ataagactac atttgtagta tattacaaat gtagtattta
      181 tgtcaaaata atgttataat ttttgtgata tggaggtgta gaaggtgtta tcatcttttt
      241 taatgttaag tataatcagt tcattgctca cgatatgtgt aattttttta gtgagaatgc
      301 tctatataaa atatactcaa aatattatgt cacataagat ttggttatta gtgctcgtct
      361 ccacgttaat tccattaata ccattttaca aaatatcgaa ttttacattt tcaaaagata
      421 tgatgaatcg aaatgtatct gacacgactt cttcggttag tcatatgtta gatggtcaac
      481 aatcatctgt tacgaaagac ttagcaatta atgttaatca gtttgagacc tcaaatataa
      541 cgtatatgat tcttttgata tgggtatttg gtagtttgtt gtgcttattt tatatgatta
      601 aggcattccg acaaattgat gttattaaaa gttcgtcatt ggaatcgtca tatcttaatg
      661 aacgacttaa agtatgtcaa agtaagatgc agttctacaa aaagcatata acaattagtt
      721 atagttcaaa cattgataat ccgatggtat ttggtttagt gaaatcccaa attgtactac
      781 caactgtcgt agtcgaaacc atgaatgaca aagaaattga atatattatt ctacatgaac
      841 tatcacatgt gaaaagtcat gacttaatat tcaaccagct ttatgttgtt tttaaaatga
      901 tattctggtt taatcctgca ctatatataa gtaaaacaat gatggacaat gactgtgaaa
      961 aagtatgtga tagaaacgtt ttaaaaattt tgaatcgcca tgaacatata cgttatggtg
     1021 aatcgatatt aaaatgctct attttaaaat ctcagcacat aaataatgtg gcagcacaat
     1081 atttactagg ttttaattca aatattaaag aacgtgttaa gtatattgca ctttatgatt
     1141 caatgcctaa acctaatcga aacaagcgta ttgttgcgta tattgtatgt agtatatcgc
     1201 ttttaataca agcaccgtta ctatctgcac atgttcaaca agacaaatat gaaacaaatg
     1261 tatcatataa aaaattaaat caactagctc cgtatttcaa aggatttgat ggaagttttg
     1321 tgctttataa tgaacgggag caagcttatt ctatttataa tgaaccagaa agtaaacaac
     1381 gatattcacc taattctact tacaaaattt atttagcgtt aatggcattc gaccaaaatt
     1441 tactctcatt aaatcatact gaacaacaat gggataaaca tcaatatcca tttaaagaat
     1501 ggaaccaaga tcaaaattta aattcttcaa tgaaatattc agtaaattgg tattacgaaa
     1561 atttaaacaa acatttaaga caagatgagg ttaaatctta tttagatcta attgaatatg
     1621 gtaatgaaga aatatcaggg aatgaaaatt attggaatga atcttcatta aaaatttctg
     1681 caatagaaca ggttaatttg ttgaaaaata tgaaacaaca taacatgcat tttgataata
     1741 aggctattga aaaagttgaa aatagtatga ctttgaaaca aaaagatact tataaatatg
     1801 taggtaaaac tggaacagga atcgtgaatc acaaagaagc aaatggatgg ttcgtaggtt
     1861 atgttgaaac gaaagataat acgtattatt ttgctacaca tttaaaaggc gaagacaatg
     1921 cgaatggcga aaaagcacaa caaatttctg agcgtatttt aaaagaaatg gagttaatat
     1981 aatggataat aaaacgtatg aaatatcatc tgcagaatgg gaagttatga atatcatttg
     2041 gatgaaaaaa tatgcaagtg cgaataatat aatagaagaa atacaaatgc aaaaggactg
     2101 gagtccaaaa accattcgta cacttataac gagattgtat aaaaagggat ttatagatcg
     2161 taaaaaagac aataaaattt ttcaatatta ctctcttgta gaagaaagtg atataaaata
     2221 taaaacatct aaaaacttta tcaataaagt atacaaaggc ggtttcaatt cacttgtctt
     2281 aaactttgta gaaaaagaag atctatcaca agatgaaata gaagaattga gaaatatatt
     2341 gaataaaaaa taaaattgtt gtgtttacaa caatacatag aaaacagagg aaacaatcaa
     2401 gtcgttgaat atttcctctg ttttttagtt gaaaaaatta accgaaagcc tgaatgcaag
     2461 tcttgattaa a
//