LOCUS       X13224                  1668 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  Human mRNA for perforin (P1).
ACCESSION   X13224 X12940
VERSION     X13224.1
KEYWORDS    cytolytic protein; perforin; protein P1.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1668)
  AUTHORS   Lichtenheld M.G., Olsen K.J., Lu P., Lowrey D.M., Hameed A.,
            Hengartner H., Podack E.R.
  TITLE     Structure and function of human perforin
  JOURNAL   Nature 335(6189), 448-451(1988).
   PUBMED   3419519
REFERENCE   2  (bases 1 to 1668)
  AUTHORS   Hameed A., Hemgartner H., Lichtenheld M.G., Lovrey D.M., Lu P.,
            Olsen K.J., Podack E.R.
  JOURNAL   Submitted (13-SEP-1988) to the INSDC. A. Hameed, H. Hemgartner,
            M.G. Lichtenheld, D.M. Lovrey, P. Lu, K.J. Olsen and E.R. Podack,
            UNIVERSITY MIAMI MEDICAL SCHOOL, POB 016960 R138, MIAMI, FAL 33101,
            USA
FEATURES             Location/Qualifiers
     source          1..1668
                     /db_xref="H-InvDB:HIT000321353"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /cell_type="IL2 lymphokine-activated killer cells"
                     /db_xref="taxon:9606"
     CDS             1..1668
                     /note="perforin (AA 1 - 555)"
                     /db_xref="GOA:P14222"
                     /db_xref="H-InvDB:HIT000321353.12"
                     /db_xref="HGNC:HGNC:9360"
                     /db_xref="InterPro:IPR000008"
                     /db_xref="InterPro:IPR020863"
                     /db_xref="InterPro:IPR020864"
                     /db_xref="InterPro:IPR035892"
                     /db_xref="InterPro:IPR037300"
                     /db_xref="UniProtKB/Swiss-Prot:P14222"
                     /protein_id="CAA31612.1"
                     /translation="MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLA
                     GEGVDVTSLRRSGSFPVDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGC
                     QRHVTRAKVSSTEAVARDAARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQ
                     KTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISN
                     YGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEA
                     KACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGIQAGPEQYSAWVNSVPG
                     SPGLVDYTLEPLHVLLDSQDPRREALRRALSQYLTDRARWRDCSRPCPPGRQKSPRDP
                     CQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWSLWGDWFTATDAYVKLFFGGQELRT
                     STVWDNNNPIWSVRLDFGDVLLATGGPLRLQVWDQDSGRDDDLLGTCDQAPKSGSHEV
                     RCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQMLLGEPPGNRSGAVW"
     misc_feature    613..621
                     /note="pot. N-linked glycosylation site"
     misc_feature    1645..1653
                     /note="pot. N-linked glycosylation site"
BASE COUNT          315 a          558 c          508 g          287 t
ORIGIN      
        1 atggcagccc gtctgctcct cctgggcatc cttctcctgc tgctgcccct gcccgtccct
       61 gccccgtgcc acacagccgc acgctcagag tgcaagcgca gccacaagtt cgtgcctggt
      121 gcatggctgg ccggggaggg tgtggacgtg accagcctcc gccgctcggg ctccttccca
      181 gtggacacac aaaggttcct gcggcccgac ggcacctgca ccctctgtga aaatgcccta
      241 caggagggca ccctccagcg cctgcctctg gcgctcacca actggcgggc ccagggctct
      301 ggctgccagc gccatgtaac cagggccaaa gtcagctcca ctgaagctgt ggcccgggat
      361 gcggctcgta gcatccgcaa cgactggaag gtcgggctgg acgtgactcc taagcccacc
      421 agcaatgtgc atgtgtctgt ggccggctca cactcacagg cagccaactt tgcagcccag
      481 aagacccacc aggaccagta cagcttcagc actgacacgg tggagtgccg cttctacagt
      541 ttccatgtgg tacacactcc cccgctgcac cctgacttca agagggccct cggggacctg
      601 ccccaccact tcaacgcctc cacccagccc gcctacctca ggcttatctc caactacggc
      661 acccacttca tccgggctgt ggagctgggt ggccgcatat cggccctcac tgccctgcgc
      721 acctgcgagc tggccctgga agggctcacg gacaacgagg tggaggactg cctgactgtc
      781 gaggcccagg tcaacatagg catccacggc agcatctctg ccgaagccaa ggcctgtgag
      841 gagaagaaga agaagcacaa gatgacggcc tccttccacc aaacctaccg ggagcgccac
      901 tcggaagtgg ttggcggcca tcacacctcc attaacgacc tgctgttcgg gatccaggcc
      961 gggcccgagc agtactcagc ctgggtaaac tccgtgcccg gcagccctgg cctggtggac
     1021 tacaccctgg aacccctgca cgtgctgctg gacagccagg acccgcggcg ggaggcactg
     1081 aggagggccc tgagtcagta cctgacggac agggctcgct ggagggactg cagccggccg
     1141 tgcccaccag ggcggcagaa gagcccccga gacccatgcc agtgtgtgtg ccatggctca
     1201 gcggtcacca cccaggactg ctgccctcgg cagaggggcc tggcccagct ggaggtgacc
     1261 ttcatccaag catggagcct gtggggggac tggttcactg ccacggatgc ctatgtgaag
     1321 ctcttctttg gtggccagga gctgaggacg agcaccgtgt gggacaataa caaccccatc
     1381 tggtcagtgc ggctggattt tggggatgtg ctcctggcca caggggggcc cctgaggttg
     1441 caggtctggg atcaggactc tggcagggac gatgacctcc ttggcacctg tgatcaggct
     1501 cccaagtctg gttcccatga ggtgagatgc aacctgaatc atggccacct aaaattccgc
     1561 tatcatgcca ggtgcttgcc ccacctggga ggaggcacct gcctggacta tgtcccccaa
     1621 atgcttctgg gggagcctcc aggaaaccgg agtggggccg tgtggtga
//