LOCUS       X12506                  2051 bp    DNA     linear   INV 14-NOV-2006
DEFINITION  Drosophila melanogaster twist gene.
ACCESSION   X12506
VERSION     X12506.1
KEYWORDS    developmental regulation; glycoprotein; nucleoprotein; twist gene.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Holometabola; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 2051)
  AUTHORS   Thisse B., Stoetzel C., Gorostiza-Thisse C., Perrin-Schmitt F.
  TITLE     Sequence of the twist gene and nuclear localization of its protein
            in endomesodermal cells of early Drosophila embryos
  JOURNAL   EMBO J. 7(7), 2175-2183(1988).
   PUBMED   3416836
COMMENT     see x14569 for twist cDNA seq
FEATURES             Location/Qualifiers
     source          1..2051
                     /organism="Drosophila melanogaster"
                     /strain="Oregon R."
                     /mol_type="genomic DNA"
                     /clone_lib="lambda EMBL 18+"
                     /db_xref="taxon:7227"
     precursor_RNA   37..2051
                     /note="minor primary transcript"
     precursor_RNA   41..2051
                     /note="major primary transcript"
     exon            41..1423
                     /number=1
     CDS             join(200..1423,1544..1792)
                     /product="twist protein"
                     /db_xref="GOA:P10627"
                     /db_xref="InterPro:IPR011598"
                     /db_xref="InterPro:IPR015789"
                     /db_xref="InterPro:IPR036638"
                     /db_xref="UniProtKB/Swiss-Prot:P10627"
                     /protein_id="CAA31024.1"
                     /translation="MMSARSVSPKVLLDISYKPTLPNIMELQNNVIKLIQVEQQAYMH
                     SGYQLQHQQQHLHSHQHHQQHHQQQHAQYAPLPSEYAAYGITELEDTDYNIPSNEVLS
                     TSSNQSAQSASLELNNNNTSSNTNSSGNNPSGFDGQASSGSSWNEHGKRARSSGDYDC
                     QTGGSLVMQPEHKKLIHQQQQQQQQHQQQIYVDYLPTTVDEVASAQSCPGVQSTCTSP
                     QSHFDFPDEELPEHKAQVFLPLYNNQQQQSQQQQQQQPHQQSHAQMHFQNAYRQSFEG
                     YEPANSLNGSAYSSSDRDDMEYARHNALSSVSDLNGGVMSPACLADDGSAGSLLDGSD
                     AGGKAFRKPRRRLKRKPSKTEETDEFSNQRVMANVRERQRTQSLNDAFKSLQQIIPTL
                     PSDKLSKIQTLKLATRYIDFLCRMLSSSDISLLKALEAQGSPSAYGSASSLLSAAANG
                     AEGDLKCLRKANGAPIIPPEKLSYLFGVWRMEGDAQHQKA"
     misc_feature    515..523
                     /note="pot. N-linked glycosylation site"
     misc_feature    557..565
                     /note="pot. N-linked glycosylation site"
     misc_feature    575..583
                     /note="pot. N-linked glycosylation site"
     misc_feature    590..598
                     /note="pot. N-linked glycosylation site"
     intron          1424..1543
                     /number=1
     exon            1544..2051
                     /number=2
     regulatory      2025..2030
                     /regulatory_class="polyA_signal_sequence"
     polyA_site      2051..2051
BASE COUNT          574 a          604 c          511 g          362 t
ORIGIN      
        1 aaaatgtcaa tttgagcaat ggccggaagg atcctgcgtc agttgcgttc cgtaagtgcg
       61 tgcgagcaga tcgatccagc aaaacgcggg cgtgaagaat atccacggag ttatacagtt
      121 ccgaaataag aatatattgt tagataccac aaattctaac gtgaagaagg tgcgctaaaa
      181 agccaagcaa gatcaccaaa tgatgagcgc tcgctcggtg tcgcccaaag tgctgctgga
      241 cataagctac aagcccacac tgcccaacat catggagctg cagaacaatg tgatcaagct
      301 gatacaggtg gagcagcagg cctacatgca ctccggctat cagctgcagc accagcagca
      361 gcacctccac tcccaccagc accaccagca gcaccaccag cagcagcatg cccagtacgc
      421 cccactgccc tcggagtacg ccgcctatgg tattaccgaa ctggaggaca cagactacaa
      481 catacccagc aacgaggtcc tgagcaccag cagcaaccag agtgcccaga gcgccagtct
      541 ggagctgaac aacaacaaca ccagcagcaa caccaacagc tccggcaaca atcccagtgg
      601 cttcgatggc caggccagca gcggatcctc ttggaacgag cacggcaaga gggccaggag
      661 cagtggcgac tacgattgcc aaaccggggg atcactggtc atgcagcccg agcacaagaa
      721 gctaatccac cagcaacagc agcagcaaca acagcaccag caacagatct atgtggatta
      781 cttgcccacc accgtggacg aggtggcctc ggctcaatct tgtcctggcg tccagagcac
      841 atgcacctcc ccgcaatccc acttcgattt tcccgacgag gagctgcccg agcacaaggc
      901 ccaggtgttc ctgcccctct acaacaacca gcagcagcag tcgcagcagc agcaacagca
      961 gcagccgcac cagcaaagcc acgcccagat gcacttccaa aacgcctaca gacaaagttt
     1021 cgagggctac gagccggcca actcgctgaa cggcagtgct tactccagct cggatcggga
     1081 tgacatggag tacgcccgcc acaacgccct gagttcagtt agcgatctca acggaggagt
     1141 catgtcgccc gcctgcttgg cggatgacgg cagtgccggc agtttgctgg acggatccga
     1201 tgccggcgga aaggccttcc gcaagccacg tcgccggctg aagcggaagc ccagcaagac
     1261 ggaggagacg gacgagttca gcaaccagcg ggtcatggcc aatgtgaggg agcgccagcg
     1321 cacccagagc ctcaacgacg ccttcaagtc cctgcagcag atcatcccca cgctgcccag
     1381 cgacaagctc agcaagatcc agaccctcaa actggccaca aggtaatata tctttagttt
     1441 acatcttcat aatagttaaa agcattcata gatagataga tagataatag atgaatgaat
     1501 cgaaactcgt aattaatcga actcttttta accaacttac agatacatcg acttcctgtg
     1561 ccgcatgctc agctcgagtg atatatcttt gctgaaggcc ttggaggccc agggatcgcc
     1621 ctcggcgtat ggatcggcca gctccctcct gagtgccgcc gccaatggag ccgaaggtga
     1681 tctgaagtgc ctgcgcaagg ccaacggagc acccattatc ccgcccgaga agctgagtta
     1741 tctgttcggg gtgtggcgca tggagggcga cgcgcagcac cagaaggcat agcggcggat
     1801 caggacacta tagctatagt cctgtttcga gaggggcttc cagcagcaac tatcgtgtga
     1861 attcagagcc ctggcgcatc tcactcttca attctctgtc acgctttcca tatatacgtg
     1921 tcgactagat gattctaaga tgtctaagcc taaaacctac tgttaatgcc tatttaatgt
     1981 catagtctaa actaaattaa ttgtaaaaag ccaacaagcc aagaaacaaa gaaacgcatg
     2041 aacaaaacca g
//