LOCUS       X07427                    93 bp    DNA     linear   HUM 14-NOV-2006
DEFINITION  H.sapiens gene for C1 inhibitor exon 2 (and joined CDS).
ACCESSION   X07427
VERSION     X07427.1
KEYWORDS    C1 inhibitor; plasma protein; protease inhibitor; serpin.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 93)
  AUTHORS   Carter P.E., Dunbar B., Fothergill J.E.
  TITLE     Genomic and cDNA cloning of the human C1 inhibitor. Intron-exon
            junctions and comparison with other serpins
  JOURNAL   Eur. J. Biochem. 173(1), 163-169(1988).
   PUBMED   3267220
COMMENT     see X07427-X07433 for C1 inhibitor genomic sequences;
            see X07577 for corresponding cDNA;
            see M14036 for cDNA sequence with slight difference (AA 165);
            see M13203 for cDNA sequence with a number of discrepancies
FEATURES             Location/Qualifiers
     source          1..93
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /clone="overlapping cosmid clones 5c, 6c and 6d"
                     /db_xref="taxon:9606"
     mRNA            join(11..93,X07428.1:11..509,X07429.1:11..145,
                     X07430.1:11..214,X07431.1:11..150,X07432.1:11..230,
                     X07433.1:11..528)
                     /gene="c1in"
     exon            11..83
                     /gene="c1in"
                     /note="label:ex2"
     CDS             join(33..83,X07428.1:11..509,X07429.1:11..145,
                     X07430.1:11..214,X07431.1:11..150,X07432.1:11..230,
                     X07433.1:11..264)
                     /gene="c1in"
                     /product="C1 inhibitor"
                     /db_xref="GOA:P05155"
                     /db_xref="HGNC:HGNC:1228"
                     /db_xref="InterPro:IPR000215"
                     /db_xref="InterPro:IPR015553"
                     /db_xref="InterPro:IPR023795"
                     /db_xref="InterPro:IPR023796"
                     /db_xref="InterPro:IPR036186"
                     /db_xref="InterPro:IPR042178"
                     /db_xref="InterPro:IPR042185"
                     /db_xref="PDB:1M6Q"
                     /db_xref="PDB:2OAY"
                     /db_xref="PDB:5DU3"
                     /db_xref="PDB:5DUQ"
                     /db_xref="UniProtKB/Swiss-Prot:P05155"
                     /protein_id="CAA30314.1"
                     /translation="MASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGK
                     VATTVISKMLFVEPILEVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQP
                     TQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAM
                     KKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGV
                     TSVSQIFHSPDLAIRDTFVNASRTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISR
                     LLDSLPSDTRLVLLNAIYLSAKWKTTFDPKKTRMEPFHFKNSVIKVPMMNSKKYPVAH
                     FIDQTLKAKVGQLQLSHNLSLVILVPQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQ
                     PTLLTLPRIKVTTSQDMLSIMEKLEFFDFSYDLNLCGLTEDPDLQVSAMQHQTVLELT
                     ETGVEAAAASAISVARTLLVFEVQQPFLFVLWDQQHKFPVFMGRVYDPRA"
     misc_feature    33..83
                     /gene="c1in"
                     /note="label:start"
BASE COUNT            8 a           34 c           31 g           20 t
ORIGIN      
        1 ggctccgcag gtccgctgac gtcgccgccc agatggcctc caggctgacc ctgctgaccc
       61 tcctgctgct gctgctggct ggggtatgtg gtc
//