LOCUS VLTB01000223 12556 bp DNA linear BCT 10-FEB-2020 DEFINITION Escherichia coli strain ATCC 11230 IBCONMGI_119, whole genome shotgun sequence. ACCESSION VLTB01000223 VLTB01000000 VERSION VLTB01000223.1 DBLINK BioProject: PRJNA555823 BioSample: SAMN12330955 KEYWORDS WGS. SOURCE Escherichia coli ORGANISM Escherichia coli Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. REFERENCE 1 (bases 1 to 12556) AUTHORS Kedziora,A., Wernecki,M., Korzekwa,K., Speruda,M., Gerasymchuk,Y., Lukowiak,A. and Bugla-Ploskonska,G. TITLE Consequences Of Long-Term Bacteria's Exposure To Silver Nanoformulations With Different PhysicoChemical Properties JOURNAL Int J Nanomedicine 15, 199-213 (2020) PUBMED 32021174 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 12556) AUTHORS Kedziora,A. and Wernecki,M. TITLE Direct Submission JOURNAL Submitted (22-JUL-2019) Department of Microbiology, Institute of Genetics and Microbiology, University of Wroclaw, Przybyszewskiego 63/77, Wroclaw 51-148, Poland COMMENT The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ ##Genome-Assembly-Data-START## Assembly Method :: SPAdes v. 3.13.1 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 80x Sequencing Technology :: Illumina MiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Date :: 07/22/2019 14:17:00 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 4.8 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region Genes (total) :: 6,675 CDSs (total) :: 6,577 Genes (coding) :: 6,206 CDSs (with protein) :: 6,206 Genes (RNA) :: 98 rRNAs :: 2, 1, 1 (5S, 16S, 23S) complete rRNAs :: 1, 1 (5S, 16S) partial rRNAs :: 1, 1 (5S, 23S) tRNAs :: 86 ncRNAs :: 8 Pseudo Genes (total) :: 371 CDSs (without protein) :: 371 Pseudo Genes (ambiguous residues) :: 5 of 371 Pseudo Genes (frameshifted) :: 158 of 371 Pseudo Genes (incomplete) :: 184 of 371 Pseudo Genes (internal stop) :: 87 of 371 Pseudo Genes (multiple problems) :: 57 of 371 CRISPR Arrays :: 2 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..12556 /organism="Escherichia coli" /mol_type="genomic DNA" /submitter_seqid="IBCONMGI_119" /strain="ATCC 11230" /culture_collection="ATCC:11230" /db_xref="taxon:562" /collection_date="2004" gene complement(<1..149) /locus_tag="FPI65_12980" CDS complement(<1..149) /locus_tag="FPI65_12980" /EC_number="1.1.1.44" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_000043504.1" /note="catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="NADP-dependent phosphogluconate dehydrogenase" /protein_id="NDR92155.1" /translation="MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIA ENPGK" gene complement(312..1682) /gene="cpsG" /locus_tag="FPI65_12985" CDS complement(312..1682) /gene="cpsG" /locus_tag="FPI65_12985" /EC_number="5.4.2.8" /inference="COORDINATES: similar to AA sequence:RefSeq:NP_310862.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="phosphomannomutase CpsG" /protein_id="NDR92156.1" /translation="MSSLPCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLG GDVRLTSETLKLALAKGLQDAGVDVLDIGMSGTEEIYFATFHLGVDGGIEVTASHNPM DYNGMKLVREGARPISGDTGLRDIQRLAEANDFPPVDETKRGRYQQINLRDAYVDHLF GYINVKNLTPLKLVINSGNGAAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPNGIP NPLLPECRDDTRNAVIKHGADMGIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLE KNPGAKIIHDPRLSWNTVDVVTAAGGTPVMSKTGHAFIKERMRKEDAIYGGEMSAHHY FRDFAYCDSGMIPWLLVAELVCLKGKTLGELVRDRMAAFPASGEINSKLAQPVEAINR VEQHFSREALAVDRTDGISMTFADWRFNLRSSNTEPVVRLNVESRGDVPLMEEKTKLI LELLNK" gene complement(1765..3204) /gene="cpsB" /locus_tag="FPI65_12990" CDS complement(1765..3204) /gene="cpsB" /locus_tag="FPI65_12990" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_001063573.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="mannose-1-phosphate guanyltransferase" /protein_id="NDR92157.1" /translation="MNNNKIITPIIMAGGSGSRLWPLSRILYPKQFLSLIGSHTMLQT TANRLDGLDCTNPYVICNEQYRFIVAEQLRKIDRLTSKNIILEPVGRNTAPAIALAAL LMSKSDKSADDLMLVLAADHVIHDEEKFCNAVRSAIPYAADGKLVTFGIIPDKAETGY GYIHRGQYINQEDSDAFIVSSFVEKPNHETATKYLASGEYYWNSGMFLFSANRYIEEL KQFRPDILSACEKAIASANFDLDFVRLDESSFSKCPEESIDYAVMEKTKDAIVIPMDA GWSDVGSWSSLWEINDKDSDGNVIVGDIFSHETKNSFIYAESGIVATVGVENLVVVQT KDAVLVSERNKVQDVKKIVEQIKNSGRSEHYVHREVYRPWGKYDSIDTGERYQVKRIT VNPGEGLSLQMHHHRAEHWIIVSGTARVTIGSETKILSENESVYIPLGVIHCLENPGK IPLDLIEVRSGSYLEEDDVIRFQDRYGRS" gene complement(3194..4399) /locus_tag="FPI65_12995" CDS complement(3194..4399) /locus_tag="FPI65_12995" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_001076403.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="glycosyltransferase" /protein_id="NDR92158.1" /translation="MNQSEQRKKILVLTPRFPYPVIGGDRLRVYMLCKELSKKYDLIL LSLCDQPLELEININDSVFKEIHRVYLPKYKSYYNVLKALVTQKPLQIAYYQSDTFKN KYNKLIKQCDAVFCHLIRVADYVKDTDKFKILDMTDAISLNYSRVKKLASKKSLRAII YSLEQKRLESYERSVANLFDLTTFISSVDRDYLYPNPGSNIHIVNNGVDTSALRYIKR EIKIDKPVELIFIGNMYSLQNMDAAKHFAKNILPCLYDEFNIIFKVIGKISETNKNIL NSFKNTIALGTVDDINSSASTGHIGICPVRLGAGVQNKILEYMALGLPCITSSIGYEG INAKSGSEIFVADTVEQYKNVLREIIYDYNRYTEVAENARSFVENNFSWESKVANLMN TLDEKLYEQ" gene complement(4420..5427) /gene="galE" /locus_tag="FPI65_13000" CDS complement(4420..5427) /gene="galE" /locus_tag="FPI65_13000" /EC_number="5.1.3.2" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_001024185.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase GalE" /protein_id="NDR92159.1" /translation="MNILVTGGAGYIGSHTAIELLNAGHEIIVLDNFSNASYKCIEKI KEITRRDFITITGDAGCRKTLSAIFEKHAIDIVIHFAGFKSVSESKSEPLKYYQNNVG VTITLLQVMEEYRIKKFIFSSSATVYGEPEIIPIPETAKIGGTTNPYGTSKYFVEKIL EDVSSTGKLDIICLRYFNPVGAHSSGKIGEAPSGIPNNLVPYLLDVASGKRDKLFIYG NDYPTNDGTGVRDFIHVVDLAKGHLAAMNYLSINSGYNIFNLGTGKGYSVLELITTFE KLTNIKVNKSFIERRAGDVASCWADADKANSLLDWQAEQTLEQMLLDSWRWKKNYPDG F" gene complement(5444..6589) /locus_tag="FPI65_13005" CDS complement(5444..6589) /locus_tag="FPI65_13005" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_000739678.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="glycosyltransferase family 4 protein" /protein_id="NDR92160.1" /translation="MKKNKKLCLISINSYNELTGGGVYLRTLVSFLQKQNVNLTLIDK KSSGKLFEDNTFQHISFIKGKRQDIISRLFFIPSFYVPYIFSIIKILRKQDILAFHNS RLGLLCLLFRILMPHKKIILFTDNFEYDLIRQKDKNITTFIEKLIVYLNEFIGLKNSD LVSYITRQDKNAMDKFYGIKKSRNLILPVIFSREKPTDVLSAHFINEYNRLNNDNRKK VVFTASFDFFPNIDAANYVLNAAKSNNDYCYILAGRKSTTLNLPDLDNLFFFDNLSNS EMSYLLSACDVFYSPIVLGSGMKTKIAEALSYGLYIYATEHSLIGYDEIINNKECVKK ISHLDEEFPKDFKMKSINKQLIMSYQQKYYSHYRFNGHELDIINFDD" gene complement(6576..7607) /locus_tag="FPI65_13010" CDS complement(6576..7607) /locus_tag="FPI65_13010" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_000587911.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="glycosyltransferase family 4 protein" /protein_id="NDR92161.1" /translation="MIIYIAAYNGSGGQGGVERVVAQQCNILKNLGVKVIILDKTYFK ISNKIRNKKIQVALYPILVSLYLTLQKLRGVTFKVIAHGYCSPFYRNDILIAHGNMKC YFQTVMNKKPNRLSGSGLLSFYERWAGAFSKNIWAVSNKVKSEWNELYNINSHKIKVV RNFINLAQFDYTDVNEAEYVTFVGRLEKGKGIDDLYYICKNLPDTSFHLVSSIPAPQN FASLNNVLTSIAVPYAKMPEIFKKSRVLILPSYYEGYELVTIEALCCGCPVIGYNVGA IRELYAESFPGVFIANNKEDLAQVAYKLISLDNEKYYHLRQTIYSKRELFSEERYAEI LTAAFNEKK" gene complement(7604..8464) /locus_tag="FPI65_13015" CDS complement(7604..8464) /locus_tag="FPI65_13015" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_001291425.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="glycosyltransferase family 2 protein" /protein_id="NDR92162.1" /translation="MSEKNVSIIIPSYNRAHILKEVIPSYFQDETLEVIVINDGSTDN TNSVLAELKEKYSQLVILENETNKKQMYSKNRGIEIAKGKYIFFGDDDSYLLPGVISR LLATKYETGADVIGARILYMNNNEKTIEDCINRHKKEGRFVSDLNRLDFSYTCDLDHP IECFYAQPFVLAERELISKYRFDISYTGNCYREETDFMLSLFIKNKKFIYDSKALLIN LPPRKATGGARTANRLKYHYESCINNYRFLKKYNDNLNLLSGQKHAIFYRQCQFVLLK MKSFIGKFLK" gene complement(8470..9813) /gene="wzy" /locus_tag="FPI65_13020" CDS complement(8470..9813) /gene="wzy" /locus_tag="FPI65_13020" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_000864941.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="O6 family O-antigen polymerase" /protein_id="NDR92163.1" /translation="MKVKAVPAITFYLSLMLTILVLLFGNEPNKSQYILVIATITVFY IAYITNKITSPASLLVISSFVFLGCRPLLSLFANYDYRIADWFIEGYMDDDVILANYA ITLMYYGYTLGLILCKNTEKFYPHGPYPEKQLLKIKFLLTLFFLGSIGMVVKGIFFFN FIESNSYVDIYQSNITTPIGYDFLSYLFYCSFFLICAFHIQFRTNKKFLFIAICIAAF STLKGSRSEAITFLLTVTCIYFNEVKTRNLRLLITMIFVFSVIFVISEFISMWRTGGS FFQLMQGNNPVINFVYGMGVSYLSIYQSVKLQLLSGGYNVTYLFSQLIITCSSIFNVK LSLPEISYSHLASYTANPELYNLGFGLGGSYLAESFLAFGLIGCFIIPFLLLLNLNVL EKYTKNKPIIYFVYYSVLPPILFTPRETLFYFFPYLVKSIFVAFLVTLYIQYKKD" gene complement(9813..11069) /gene="wzx" /locus_tag="FPI65_13025" CDS complement(9813..11069) /gene="wzx" /locus_tag="FPI65_13025" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_001297889.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="O6 family O-antigen flippase" /protein_id="NDR92164.1" /translation="MNRIQRVHNYLRLKDKIKNVFLGLYILQLFNYIAPLVIIPILIK YIGLGEYGELVYITSIYQIVALIIDFGFTYTGPVVAARHRCETQNLQRYYSIVVLLKS LLFIIALTCVFLLCRLNIVHLSFFGFLSIFLCTIGNILSPNWFLQGIGDFKKLSYSQV IVRITLFIILLVYVCSGGDNVFILSFLQNATLLICCIYLWPNIHISHVVHLKPNECIV EFKKAGNVFIGVIGTIGYNGLIPVLIGNLCGNTSLGVFSIVQKMTTACQSLINPISQY MLSQVSEIKPQDKLFYYRIKKSFFVHLTISIIACLCYMGLGQYVATFIGKVDVSFVII LFASIITIFSSLNNVLGIQFLIPTDNVKILRSINVMAGIIVVSLSWLLISRFDILGGV LLNLIGEFLVFSMLAFIAHRKWGARV" gene complement(11426..12319) /gene="galF" /locus_tag="FPI65_13030" CDS complement(11426..12319) /gene="galF" /locus_tag="FPI65_13030" /EC_number="2.7.7.9" /inference="COORDINATES: similar to AA sequence:RefSeq:NP_310873.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="UTP--glucose-1-phosphate uridylyltransferase GalF" /protein_id="NDR92165.1" /translation="MTNLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYIVDEI VAAGIKEILLVTHASKNAVENHFDTSYELESLLEQRVKRQLLAEVQSICPPGVTIMNV RQGEPLGLGHSILCARPAIGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNETGRS QVLAKRMPGDLSEYSVIQTKEPLDREGKVSRIVEFIEKPDQPQTLDSDIMAVGRYVLS ADIWPELERTQPGAWGRIQLTDAIAELAKKQSVDAMLMTGDSYDCGKKMGYMQAFVKY GLRNLKEGAKFRKGIEKLLSE" BASE COUNT 3986 a 2539 c 2081 g 3950 t ORIGIN 1 tttttgcctg gattttcggc aatcacttct tccgtctttt cacgggaacg gttgaaaata 61 gagacggtat aaccacgact ttcgatgttg agcgcaaggt tgcgccccat cactgccata 121 ccgactacgc cgatctgttg ctttgacatt gtttactcct gtcaggggtg gtcaccgcga 181 agtgtgcggc ttaaatgtgg tatagatgtt aactcactca tagagatact gaatagcatt 241 accttggata taccacaccg gatatctcat cttttccgtt ttttaaaacc catttatatg 301 aaattactga attacttgtt cagtaactca aggataagtt ttgtcttttc ttccatcagc 361 ggtacatcgc cgcgcgattc cacattcaac cgcaccaccg gttcggtgtt ggaggagcgc 421 aggttaaagc gccagtcggc aaaggtcatg ctgatgccat cggtacgatc caccgccagc 481 gcctcacggc taaaatgctg ttccacgcgg ttaatcgcct caacgggttg cgccagtttg 541 ctgttgatct caccgcttgc cggaaacgct gccatccggt cgcgcaccag ttcgcccagc 601 gtttttcctt tcaggcacac cagttcggcg accagcagcc acgggatcat gccgctgtcg 661 cagtaagcga aatcacggaa gtaatggtgg gcgctcattt cgccaccgta gatagcgtct 721 tccttgcgca tacgttcttt aataaaggcg tgtccggttt tcgacattac cggggtgccg 781 cctgcggcag tcaccacatc aacggtgttc caggagagac gtggatcgtg gatgatcttc 841 gcgccgggat ttttttcgag gaacgcttct gccagcaggc cgacaatgta gtagccctca 901 ataaactgcc ctttttcgtc aaacaggaaa cagcggtcaa aatcgccatc aaaggcaatg 961 cccatatccg cgccgtgttt gatgaccgca ttgcgggtgt cgtcgcgaca ttccggcagt 1021 agcgggttag gaataccgtt ggggaaattg ccgtccggcg tgttgtgcac tttgattaat 1081 tccacgggtg cgccgagggc tttaaagcgg gcttcaatgg cgtccaccac cggacccgcc 1141 gcgccgttcc cggagttaat caccagcttg agcggcgtga ggtttttgac gttgatataa 1201 ccgaacaggt gatcaacgta agcgtcacgc agattgattt gctgatagcg accgcgtttg 1261 gtttcatcaa cgggaggaaa gtcgttggct tctgccagac gctggatgtc gcgcagtccg 1321 gtatcaccgc tgatcgggcg agccccttcg cgcaccagtt tcatgccgtt gtaatccatc 1381 gggttatggc tggcggtaac ttcgatgccg ccatccacgc cgagatggaa cgtggcgaaa 1441 tagatttctt cggtgccgga catgccaata tccagcacat cgacgcccgc atcctgtaac 1501 cccttcgcca gcgccagttt taaggtttcg ctggtgagtc ggacgtcacc gcctaacaca 1561 atggttttcg gtttgagaaa ttcgccataa gcgcgaccaa tgcgccaggc aatatcttca 1621 ttcagttctt cgcctaattt cccgcgaata tcataggctt taaagcaggg taaactcgac 1681 atgatatacc ttaaacaaat aatacttatt acagattaac taaaaatatt agcgctcttc 1741 tactaacgtt acattatcaa aaatttagct acgaccatat cggtcctgaa aacggataac 1801 atcgtcttct tctaaataag atccagaacg aacttcaatt aaatcaagag gaattttccc 1861 tggattttcc aagcagtgta ttacaccaag aggtatgtaa acagattcat tttcgctaag 1921 aatcttagtt tcagaaccta tagtcaccct tgcagttcca gaaactatga tccaatgttc 1981 tgccctatga tggtgcattt gtaaagaaag tccttcacca ggatttactg ttatacgttt 2041 gacctgataa cgctcccctg tgtcaatgga atcatattta ccccaaggac gatatacttc 2101 gcgatgaaca taatgctcgc tacgacctga atttttaatt tgttcgacta ttttctttac 2161 atcctgaact ttatttctct ctgagacaag aacagcatcc tttgtttgga caacaactaa 2221 attttccact ccaactgtag caacaattcc cgattcggca tatatgaaag aattctttgt 2281 ttcatgagag aaaatatccc caactattac gttgccgtct gagtctttat cattaatttc 2341 ccaaagagaa gaccatgaac cgacatcact ccagccagca tccattggaa taacaattgc 2401 gtcttttgtt ttttccatta cagcgtaatc aattgactct tcaggacact tagagaaaga 2461 actttcatct aaacgcacaa aatcaaggtc aaagttcgct gaagcaattg ctttttcaca 2521 agcggataaa atatcaggcc gaaattgttt aagttcctct atataacgat ttgcactaaa 2581 caaaaacata ccgctattcc aataatactc accggaagca agatatttag tggctgtctc 2641 atgatttggc ttttcaacaa atgatgacac tataaatgca tccgaatctt cctgattaat 2701 atattgtcct cgatgtatat aaccataacc agtttctgct ttgtctggaa ttataccaaa 2761 tgttaccaat ttcccatcag cagcgtatgg aattgccgat ctaacagcgt tacaaaattt 2821 ttcttcatcg tgtataacgt gatctgcagc cagtacgagc ataagatcat ctgcactttt 2881 atcagactta gacatcagca acgccgctaa tgcaattgca ggggcagtgt tacgcccaac 2941 aggctcaagg atgatattct ttgaagtcaa tctatcgatt tttctaagct gttcagcaac 3001 tataaagcgg tattgttcat tacaaatgac ataagggttg gtacaatcca aaccatccag 3061 acgattagcc gttgtttgaa gcatggtatg actaccgatt aggctaagaa attgtttcgg 3121 atagagaatt cttgatagtg gccacaaccg actgcctgaa ccaccagcca taatgatagg 3181 tgtaataatt ttattattgt tcatataatt tctcatctaa tgtattcatt aaattggcaa 3241 cttttgattc ccaagaaaaa ttattttcta caaaactacg ggcattttca gccacttcag 3301 tataacgatt ataatcgtaa attatttctc ttagtacgtt tttatattgc tctactgtat 3361 ctgcaacaaa aatttcgcta cctgattttg cattaatacc ttcataacca atgctagatg 3421 taatacatgg taaacctaaa gccatgtatt caagaatttt attttgtacg cctgctccaa 3481 gacgaacagg acatatacct atatgccctg tagaagcgga agaattgata tcatcaacag 3541 tacctaaagc aattgtattt ttaaatgaat ttaatatatt tttattagtt tctgagatct 3601 taccaatcac tttaaaaata atattaaact catcatacaa gcaaggtaaa atattcttag 3661 caaaatgttt tgcagcatcc atattttgta aagaatacat atttccgata aatataagtt 3721 ccacaggctt atcgattttt atttctcttt ttatatatct caaggctgat gtatcaaccc 3781 cattattgac tatatggata ttactgcccg gattagggta gagatagtca cggtctacgg 3841 atgaaataaa agtggtcaaa tcaaaaagat tcgccacaga acgttcatat gattctaatc 3901 ttttttgttc cagagaataa ataattgcac gcaaactttt tttacttgct aattttttaa 3961 cgcgactgta attcaaagat attgcatctg tcatatcaag aattttgaac ttgtctgtat 4021 ccttaacata atcagcaact cttatcagat gacaaaatac tgcatcgcat tgtttaatta 4081 atttattgta tttattctta aatgtgtccg attgataata agcaatttgc aacggttttt 4141 gcgtaaccaa agcttttaat acattataat atgatttata ttttggtaga tagacacgat 4201 gaatttcttt gaagaccgag tcatttatat ttatttcaag ttctagtggt tgatcacata 4261 agctcagaag aataagatca tattttttgg aaagttcttt acataacata tagactctta 4321 atctatcccc tccaatgaca gggtagggaa agcgaggtgt aagaaccagt attttttttc 4381 tctgctctga ttgattcata aaactgaaac cttttatatt cagaatccgt ctggataatt 4441 ttttttccaa cgccacgagt ccaataacat ctgttctaga gtttgttcgg cttgccagtc 4501 caataaagaa ttagctttat ctgcatcagc ccaacaagac gcaacatccc ctgcccttct 4561 ctctataaaa gatttattga ccttaatgtt tgttaatttt tcaaatgtag tgattaattc 4621 aagcaccgaa taaccttttc ctgtaccaag attaaagata ttatatcccg aattgatact 4681 taaataattc attgcagcca aatgaccttt cgctaagtca acaacatgaa taaaatccct 4741 tacacctgtt ccatcattag tagggtaatc attgccataa ataaataatt tatcacgttt 4801 accactcgca acatccaata aataaggaac aagattatta gggataccag atggagcctc 4861 acctatttta ccactagaat gagcaccgac aggattaaaa tatctcaagc aaattatatc 4921 cagttttccc gtggaactaa catcctctag aattttttca acaaaatact tcgatgtgcc 4981 atatggattc gtagttcctc caattttagc tgtttctgga attggaatta tctctggttc 5041 accatagact gtcgcagatg agctaaagat aaatttttta attctgtact cttccattac 5101 ctgtaataaa gtaatggtca ctccaacatt attctggtaa tactttaagg gttcactttt 5161 agactctgaa acagatttaa agccagcaaa atgaataact atatctatgg cgtgtttctc 5221 gaaaatagcg gagagtgtct tcctacaccc agcatctcca gtaattgtta taaaatcacg 5281 tcgagtaatt tcttttattt tttcgataca cttgtatgaa gcattactga aattgtccag 5341 aacgataatc tcatgacctg cattcagtaa ttcaatagcc gtatgagatc cgatatatcc 5401 agcaccacca gttactaata tgttcatatt atatctccac taactaatcg tcaaaattta 5461 ttatatcaag ttcatggcca ttaaaccgat aatgtgaata atatttttgc tgataagaca 5521 ttattagctg tttattgata cttttcatct tgaaatcttt aggaaattcc tcatccaaat 5581 gtgagatttt tttaacacac tccttattgt ttataatttc atcatagccg attaaggaat 5641 gctctgtcgc ataaatatat aatccatatg atagtgcttc tgcaattttt gttttcattc 5701 cacttcctaa aactatagga gaataaaaaa catcacaagc agataataaa tatgacattt 5761 cactattaga tagattatcg aaaaaaaata aattatccaa atcaggaaga ttcaaagtag 5821 tacttttcct acctgccaaa atatagcaat aatcattatt agactttgct gcatttaaaa 5881 catagttggc agcatctata tttggaaaaa aatcaaaaga tgcagtaaat actacttttt 5941 tcctattatc attattcaat cgattatact cattaataaa gtgagctgac aatacatcag 6001 ttggtttttc tctactaaat atcacaggga gaattaaatt tctgcttttt ttaatcccat 6061 aaaatttatc cattgcattt ttatcttgcc gggtaatata gctaactaaa tctgaattct 6121 taagcccgat aaattcattg agataaacaa ttaatttttc aataaaagta gttatgtttt 6181 tatctttttg tcttattaag tcatattcga agttatccgt aaacaatatg atctttttgt 6241 ggggcatgag tattctaaaa agcagacata acaatccaag ccgagagttg tgaaaagcaa 6301 gaatatcttg cttccgtaaa attttaatta ttgagaaaat ataagggaca taaaatgatg 6361 gtataaaaaa aagcctggat attatatcct gacgtttacc tttaataaat gatatatgtt 6421 gaaaagtatt gtcttcgaat agtttacctg aggatttttt atcaataagt gttaaattaa 6481 cattctgttt ttgtagaaaa ctaacaagcg tacgtaaata tactcctcct ccggtaagtt 6541 cattatatga gttaattgaa atgagacaga gtttcttatt ttttttcatt aaatgccgcc 6601 gttaaaattt ccgcatatct ctcttcagaa aaaagctcac gcttgctata aatagtttgt 6661 ctcaaatgat aatatttttc attatcaaga ctaattaatt tgtaggctac ttgtgctaaa 6721 tcttctttat tattggcaat aaatacgcca ggaaaacttt ctgcatacaa ctctctaatt 6781 gcaccaacat tatagcctat cacagggcaa ccacagcata gcgcttcaat agtaaccagc 6841 tcatatcctt cataatagga cggtaaaata agtactctgg atttcttaaa tatttctggc 6901 attttcgcat aggggacagc aatgctggtc agaacattat ttagcgaagc aaaattttgt 6961 ggggcgggaa tacttgaaac taaatggaag gaagtatctg gcagattttt acatatgtaa 7021 tacagatcat ctattccttt tcctttttcc aatcgcccga caaatgtcac atattctgct 7081 tcattaacat cagtgtaatc aaattgtgca agatttataa aatttcgaac aactttgatt 7141 ttatgtgaat taatattgta aagctcattc cattcacttt taaccttatt tgaaacagcc 7201 cagatatttt ttgaaaatgc tccagcccaa cgctcataga aagataaaag accactgcca 7261 gacaaccgat taggtttttt attcatgact gtttgaaaat aacatttcat attgccatga 7321 gctattaaga tgtcattcct ataaaaagga gaacaatagc catgtgcaat aactttaaac 7381 gtcacgccac gtaatttttg taaggttaaa taaagagaaa ctaatattgg ataaagtgct 7441 acttgtattt ttttgttacg aattttgtta gaaattttga agtatgtttt atcaagtata 7501 atgactttaa cccccaaatt tttaagaatg ttacattgtt gggcaacaac cctttccacc 7561 ccaccttgcc ctcctgaacc attatacgcg gcgatatata taatcatttt aaaaacttcc 7621 cgataaacga cttcattttt agcagaacga attgacactg tcggtaaaat atagcatgct 7681 tttgtcctga aagaagattc aaattatcat tatatttttt taaaaatcta taattattta 7741 tgcaactttc gtaatgatat tttaatcgat tagctgttct tgcccctccc gtcgcttttc 7801 ttggaggtaa atttattaac aaagcctttg aatcatatat aaatttttta tttttaataa 7861 atagagatag catgaaatca gtttcctcac gatagcagtt tcccgtataa gatatatcaa 7921 atcgatattt cgatattagt tccctttcag ctagaacaaa aggctgtgca taaaaacatt 7981 caatcggatg gtccaaatca catgtataac taaaatccaa tctatttaga tcactaacaa 8041 aacgcccctc ttttttatgt cgatttatgc aatcttcaat tgttttctcg ttattattca 8101 tataaagtat tcttgcgccg attacatcag cgcctgtctc atattttgta gccaataacc 8161 gagatataac accgggtaag aggtaagagt catcatcacc aaaaaaaata tatttccctt 8221 tggctatttc aatccctcgg tttttagaat acatctgttt tttattcgtt tcattttcta 8281 aaataactaa ctgagaatat ttttccttca gttcagctaa tacactattt gtattatctg 8341 ttgatccatc attgataact ataacctcta aagtctcatc ctgaaaataa cttggtatga 8401 cctccttaag aatatgagcc ctgttataac ttgggattat tatgctgaca tttttttctg 8461 acattttggt caatcctttt tatactggat gtataatgta actaaaaaag caacaaatat 8521 acttttgaca agatagggga agaaatagaa caaagtctct cttggtgtga ataatatagg 8581 tggcaacaca ctataataaa caaaatatat aattggtttg ttttttgtat atttttccaa 8641 tacatttaaa ttaagtaaaa gtaaaaaggg tataatgaaa catccaatca gaccaaatgc 8701 taaaaacgat tctgctaaat aactcccccc aagtccgaac ccaagattat atagttctgg 8761 gtttgctgtg tatgaggcca aatggctata gcttatttcc ggcaagctca atttaacatt 8821 aaatattgac gagcaagtta ttattaactg gctgaataga taggtaacat tatatccccc 8881 tgacaatagt tgtagtttta ctgattgata aatggaaaga tatgatactc ccatgccgta 8941 tacaaagttt ataacaggat tattaccctg cattaattga aaaaaactcc ctccagtgcg 9001 ccacattgag ataaattcac taatcacaaa aatgacgcta aaaacaaaaa tcattgtaat 9061 cagcagacgt aagtttcttg tctttacttc attaaaatat atacatgtaa ccgttaaaag 9121 aaacgttata gcttcactac gactaccctt caaggtgcta aatgcagcaa tgcatatcgc 9181 aataaaaaga aattttttat ttgttctgaa ctgtatatga aacgcacata taaggaaaaa 9241 agaacaataa aataaataag atagaaaatc ataacctatt ggcgttgtta tatttgattg 9301 ataaatatca acataactat tagattctat aaagttaaaa aagaatatcc cttttacaac 9361 catacctatc gaacccagaa aaaataaagt caaaagaaac tttattttta gcaattgttt 9421 ttcaggataa ggaccatgcg gataaaattt ttcagtattt ttgcatagaa ttagtcccaa 9481 tgtataacca taatacatta gtgttatagc atagttagcc aaaatcacat cgtcatccat 9541 atatccttca ataaaccaat cggcaatcct ataatcatag tttgcaaaca aagataataa 9601 agggcgacaa cctaaaaaca caaaagatga tataacgaga aggctggccg gagaagttat 9661 tttattagtg atatatgcga tataaaaaac tgttatcgtt gctataacaa ggatatattg 9721 tgatttattt ggttcattac caaacagtaa cactaaaatt gtcagcatta aacttaaata 9781 gaatgtaata gcaggaaccg ccttcacttt cattatactc tcgctcccca ctttcgatgg 9841 gcaataaaag ctagcatact gaatacaaga aactcaccaa ttaggtttaa taaaaccccc 9901 cccagaatgt caaagcgtga tattaacagc caggacaaac taacaacaat aattcccgcc 9961 ataacattta tacttcgtag tatttttaca ttatctgtcg gtataagaaa ctgtatacca 10021 aggacattat ttaaagatga aaaaatggta attattgacg caaataaaat aataacaaat 10081 gaaacgtcaa ctttacctat aaaagtcgcc acatattgcc ctaatcccat ataacataaa 10141 catgcaatta tgctaattgt taaatgcaca aaaaaacttt ttttaattct ataataaaac 10201 agtttatctt gaggtttaat ttctgaaact tgagataaca tatactgtga tattggatta 10261 attagacttt gacatgctgt tgtcattttt tgaacgattg aaaaaacacc aagactcgta 10321 ttaccgcaaa ggtttccaat taacacagga attagaccat tgtaaccaat cgtacctatt 10381 acgccaataa aaacatttcc tgccttctta aattccacaa tgcattcatt aggtttaaga 10441 tgaacaacat ggctaatatg aatatttggc cataagtata tacagcatat gagtaatgtt 10501 gcattttgca aaaaacttag gataaaaaca ttatctccgc cactacagac ataaacaaga 10561 agtatgataa acaatgttat tctcactatt acttgtgagt atgaaagttt tttaaaatca 10621 ccaatcccct gcaaaaacca attgggcgat aatatattac caatagtgca tagaaaaatt 10681 gacaaaaacc caaaaaatga caagtggact atatttaatc tgcacaataa aaatacacat 10741 gttaatgcaa ttataaaaag caatgatttt aaaagaacaa ctattgagta atagcgctgt 10801 aaattttggg tctcacatct atgtctcgca gcaaccacag gtcctgtgta agtaaagcca 10861 aaatcaataa tcaaagccac tatttgataa atagatgtaa tatagaccaa ttccccatat 10921 tcccccaacc caatatattt tatcaggata gggataatta ccaatggcgc gatataatta 10981 aataactgca atatatacaa ccctaaaaat acgtttttta ttttatcttt aagccttaaa 11041 taattgtgca cacgttgtat cctattcatt taggtgtaat tatattattg aaatgcgatg 11101 ttctataaga atgactttat aatttcagca cgctaccgcc cctggcttta cagctaccag 11161 agcactgcat gcatgcctac gatgtagcga gcgttaccca ctcgcgctaa acccgaaaaa 11221 ttcaaacgct aattgtctta ccaatccgct ctggaaacaa ggaaaatcct ggaaaacttt 11281 gactaaaatc ctattgctaa ctcgttgtta ttctgattgt ttatataaaa caacggcagg 11341 aaaattcgca acaaattact ttcgccacga atcttcactg ccgttataat tttcttatca 11401 accgttacat tcggtcagat tttcattatt cgcttaacag cttctcaatc cctttacgga 11461 acttcgcccc ttctttcagg ttgcgtagtc catacttcac aaatgcctgc atatacccca 11521 tttttttacc gcagtcgtag ctgtcacctg tcatcagcat ggcatcaacg gactgttttt 11581 tcgccagttc agcgatggca tcagtcagct gaatacgccc ccatgcacca ggctgagtgc 11641 gttcaagttc cggccaaata tctgcagaaa gcacatagcg accaacggcc atgatgtctg 11701 agtccagcgt ctgcggctga tccggttttt cgataaattc aacaatgcgg ctgactttac 11761 cttcgcgatc cagcggttct ttggtctgaa tgacggagta ttcagagagg tcacccggca 11821 tacgttttgc cagcacctgg ctgcggcccg tttcgttgaa gcgcgcaatc atggcagcaa 11881 ggttgtaacg tagcgggtcg gcgctggcat cgtcgatcac aacgtctggc agtaccacga 11941 caaatgggtt gtcaccaatg gcaggtcgcg cacacaaaat ggaatggccc aaacctaaag 12001 gttcgccctg acgcacgttc ataattgtca cgcccggcgg gcaaatggac tgtacttccg 12061 ccagcagttg gcgcttcacg cgctgttcaa ggagagattc taattcataa gaggtgtcga 12121 agtggttttc gaccgcgttc ttggaagcgt gagttaccag gaggatttct ttgatccctg 12181 cagccacaat ctcgtcaacg atgtactgaa tcattggctt gtcgacgatc ggtagcatct 12241 ctttgggaat cgccttagtg gcaggcaaca tatgcatccc aagacccgct acaggaataa 12301 ctgcttttaa attcgtcatt atttcatcca cctgtaaaat ggttgctgaa ttatagcttg 12361 ttcgattttt ttcgccagca tcaattaccc tgaattgatt actgaattac ttgtgatgtt 12421 acgccgcttc gttgtggatt gcagtagcat tgttcctaag tatggctcca tttttccagg 12481 aatggtcgca aatctactcc ctccgttctg gcaatctaaa gttaatcttc tccacattaa 12541 caatatggtg attaat //