LOCUS V00523 1027 bp mRNA linear HUM 07-OCT-2008 DEFINITION Human mRNA for histocompatibility antigen HLA-DR (fragment). The alpha chain. ACCESSION V00523 J00196 VERSION V00523.1 KEYWORDS complementary DNA; histocompatibility antigen. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1027) AUTHORS Larhammar D.G., Gustafsson K., Claesson L., Bill P., Wiman K.G., Schenning L., Sundelin J., Widmark E., Peterson P.A., Rask L. TITLE Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins JOURNAL Cell 30(1), 153-161(1982). PUBMED 6812963 COMMENT The N-terminal protein sequence has also been obtained and gives information about the 6 N-terminal amino acids. The complete amino acid sequence is: IKEDHVIIQA EFYLNPDQDG EFMFDFDGDE IFHVDMAKKE TVWRLEEFGR FACFEAQGAL ANIAVDKANL EIMTKRSNYT PITNVPPEVT VLTNSPVELR EPNVLICFID KFTPPVVNVT WLRNGKPVTT GVSETVFLPR EDHLFRKFHY LPFLPSTEDV YDCRVEHWGL DEPLLKHWEF DAPSPLPETT ENVVCALGLT VGLVGIIIGT IFIIKGVRKS NAAERRGPL The W in position 178 corresponds to a termination codon in the nucleotide sequence which may be a cloning or splicing artefact. Data kindly reviewed (15-JUL-1983) by D. Larhammar FEATURES Location/Qualifiers source 1..1027 /db_xref="H-InvDB:HIT000320813_05" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" mRNA <1..>1027 CDS <1..518 /codon_start=3 /product="histocompatibility antigen HLA-DR" /note="alpha chain" /db_xref="GOA:P01903" /db_xref="H-InvDB:HIT000320813_02.4" /db_xref="HGNC:HGNC:4947" /db_xref="InterPro:IPR001003" /db_xref="InterPro:IPR003006" /db_xref="InterPro:IPR003597" /db_xref="InterPro:IPR007110" /db_xref="InterPro:IPR011162" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014745" /db_xref="InterPro:IPR036179" /db_xref="PDB:1A6A" /db_xref="PDB:1AQD" /db_xref="PDB:1BX2" /db_xref="PDB:1D5M" /db_xref="PDB:1D5X" /db_xref="PDB:1D5Z" /db_xref="PDB:1D6E" /db_xref="PDB:1DLH" /db_xref="PDB:1FV1" /db_xref="PDB:1FYT" /db_xref="PDB:1H15" /db_xref="PDB:1HQR" /db_xref="PDB:1HXY" /db_xref="PDB:1J8H" /db_xref="PDB:1JWM" /db_xref="PDB:1JWS" /db_xref="PDB:1JWU" /db_xref="PDB:1KG0" /db_xref="PDB:1KLG" /db_xref="PDB:1KLU" /db_xref="PDB:1LO5" /db_xref="PDB:1PYW" /db_xref="PDB:1R5I" /db_xref="PDB:1SEB" /db_xref="PDB:1SJE" /db_xref="PDB:1SJH" /db_xref="PDB:1T5W" /db_xref="PDB:1T5X" /db_xref="PDB:1YMM" /db_xref="PDB:1ZGL" /db_xref="PDB:2FSE" /db_xref="PDB:2G9H" /db_xref="PDB:2IAM" /db_xref="PDB:2IAN" /db_xref="PDB:2ICW" /db_xref="PDB:2IPK" /db_xref="PDB:2OJE" /db_xref="PDB:2Q6W" /db_xref="PDB:2SEB" /db_xref="PDB:2WBJ" /db_xref="PDB:2XN9" /db_xref="PDB:3C5J" /db_xref="PDB:3L6F" /db_xref="PDB:3O6F" /db_xref="PDB:3PDO" /db_xref="PDB:3PGC" /db_xref="PDB:3PGD" /db_xref="PDB:3QXA" /db_xref="PDB:3QXD" /db_xref="PDB:3S4S" /db_xref="PDB:3S5L" /db_xref="PDB:3T0E" /db_xref="PDB:4AEN" /db_xref="PDB:4AH2" /db_xref="PDB:4C56" /db_xref="PDB:4E41" /db_xref="PDB:4FQX" /db_xref="PDB:4GBX" /db_xref="PDB:4H1L" /db_xref="PDB:4H25" /db_xref="PDB:4H26" /db_xref="PDB:4I5B" /db_xref="PDB:4IS6" /db_xref="PDB:4MCY" /db_xref="PDB:4MCZ" /db_xref="PDB:4MD0" /db_xref="PDB:4MD4" /db_xref="PDB:4MD5" /db_xref="PDB:4MDI" /db_xref="PDB:4MDJ" /db_xref="PDB:4OV5" /db_xref="PDB:4X5W" /db_xref="PDB:4X5X" /db_xref="PDB:4Y19" /db_xref="PDB:4Y1A" /db_xref="PDB:5JLZ" /db_xref="PDB:5LAX" /db_xref="PDB:5NI9" /db_xref="PDB:5NIG" /db_xref="PDB:5V4M" /db_xref="PDB:5V4N" /db_xref="PDB:6ATF" /db_xref="PDB:6ATI" /db_xref="PDB:6ATZ" /db_xref="PDB:6BIJ" /db_xref="PDB:6BIL" /db_xref="PDB:6BIN" /db_xref="PDB:6BIR" /db_xref="PDB:6BIV" /db_xref="PDB:6BIX" /db_xref="PDB:6BIY" /db_xref="PDB:6BIZ" /db_xref="PDB:6CPL" /db_xref="PDB:6CPN" /db_xref="PDB:6CPO" /db_xref="PDB:6CQJ" /db_xref="PDB:6CQL" /db_xref="PDB:6CQN" /db_xref="PDB:6CQQ" /db_xref="PDB:6CQR" /db_xref="UniProtKB/Swiss-Prot:P01903" /protein_id="CAA23782.1" /translation="IIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGR FASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICF IDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVE HWGLDEPLLKH" BASE COUNT 248 a 259 c 240 g 280 t ORIGIN 1 tgatcatcca ggccgagttc tatctgaatc ctgaccaatc aggcgagttt atgtttgact 61 ttgatggtga tgagattttc catgtggata tggcaaagaa ggagacggtc tggcggcttg 121 aagaatttgg acgatttgcc agctttgagg ctcaaggtgc attggccaac atagctgtgg 181 acaaagccaa cctggaaatc atgacaaagc gctccaacta tactccgatt accaatgtac 241 ctccagaggt aactgtgctc acgaacagcc ctgtggaact gagagagccc aacgtcctca 301 tctgtttcat cgacaagttc accccaccag tggtcaatgt cacgtggctt cgaaatggaa 361 aacctgtcac cacaggagtg tcagagacag tcttcctgcc cagggaagac caccttttcc 421 gcaagttcca ctatctcccc ttcctgccct caactgagga cgtttacgac tgcagggtgg 481 agcactgggg cttggatgag cctcttctca agcactagga gtttgatgct ccaagccctc 541 tcccagagac tacagagaac gtggtgtgtg ccctgggcct gactgtgggt ctggtgggca 601 tcattattgg gaccatcttc atcatcaagg gagtgcgcaa aagcaatgca gcagaacgca 661 gggggcctct gtaaggcaca tggaggtgat ggtgtttctt agagagaaga tcactgaaga 721 aacttctgct ttaatgactt tacaaagctg gcaatattac aatccttgac ctcagtgaaa 781 gcagtcatct tcagcgtttt ccagccctat agccacccca agtgtggtta tgcctcctcg 841 attgctccgt actctaacat ctagctggct tccctgtcta ttgccttttc ctgtatctat 901 tttcctctat ttcctatcat tttattatca ccatgcaatg cctctggaat aaaacataca 961 ggagtctgtc tctgctatgg aatgccccat ggggcatctc ttgtgtactt attgtttaag 1021 gtttcct //