LOCUS HSU78168 3394 bp mRNA linear HUM 05-FEB-1999 DEFINITION Homo sapiens cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI) mRNA, complete cds. ACCESSION U78168 VERSION U78168.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3394) AUTHORS Kawasaki,H., Springett,G.M., Mochizuki,N., Toki,S., Nakaya,M., Matsuda,M., Housman,D.E. and Graybiel,A.M. TITLE A family of cAMP-binding proteins that directly activate Rap1 JOURNAL Science 282 (5397), 2275-2279 (1998) PUBMED 9856955 REFERENCE 2 (bases 1 to 3394) AUTHORS Kawasaki,H., Housman,D.E. and Graybiel,A.M. TITLE Direct Submission JOURNAL Submitted (14-NOV-1996) Center for Cancer Research/Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E17-540, Cambridge, MA 02135, USA FEATURES Location/Qualifiers source 1..3394 /db_xref="H-InvDB:HIT000221411" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="12" /map="12q13" gene 1..3394 /gene="cAMP-GEFI" CDS 216..2861 /gene="cAMP-GEFI" /note="GEF domain shows highest similarity to RasGEF family; contains cyclic AMP binding domain" /codon_start=1 /product="cAMP-regulated guanine nucleotide exchange factor I" /protein_id="AAD12740.1" /translation="MVLRRMHRPRSCSYQLLLEHQHPSCIQGLRWTPLTNSEESLDFS ESLEQASTERVLRAGRQLHQHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGL GVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELA EAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAV LLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVND APRAATIILREYNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPS RPPTPGRNRYTVMSGTPDKILELLLEAMGLDSSAHDPKETFLSDFLLTHRVFMPSAQL CAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLHK LSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLPGS SCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQVLVKVNSAG DAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDL AGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL CPVPGPRAQLLKKFIKLAAHLKEQKNVNSFFAVMFGLSNSPISRLAHTWERLPHKVRK LYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFE KMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPAST WAYVQQLKVIDNQRELSRLSRELEP" BASE COUNT 721 a 996 c 1042 g 635 t ORIGIN 1 ggatcccctt atcaaagctg atgggggtcg ctggggaccc cccagccttt tgctagagcc 61 tgcacggctg tgggagcttg aaaagaaaca tgaaggtggg ctggccaggt gagagctgct 121 ggcaggtggg cctggctgtg gaggatagcc cagctctggg agcaccgcgg gtgggagccc 181 tccctgacgt ggtgccggag gggacactac tcaacatggt gttgagaagg atgcaccggc 241 cccgaagctg ctcctaccag ctgctgctgg agcaccagca tccgagctgc atccaggggc 301 tgcgctggac accactcacc aacagcgagg agtccctgga tttcagcgag agcctggagc 361 aggcctccac agagcgggtg ctcagggctg ggaggcagct gcatcagcat ctactggcca 421 cctgcccaaa cctcatccga gaccggaagt accaccttag gctctatcgg cagtgctgct 481 ctggccggga gctggtggat gggatcttgg ccctgggact tggggtccat tcccggagcc 541 aagttgtggg aatctgccag gtgctgctgg atgaaggtgc cctctgccat gtgaaacacg 601 actgggcctt ccaggaccga gatgcccaat tctaccggtt ccccgggccc gagcccgagc 661 ccgtgggaac tcatgagatg gaggaggagt tggccgaagc tgtggccctg ctctcccagc 721 gggggcctga cgccctgctc actgtggcac ttcgaaagcc cccaggtcag cgcacggatg 781 aagagctgga cctcatcttt gaggagctgc tgcacatcaa ggctgtggcc cacctctcca 841 actcggtgaa gcgagaatta gcggctgttc tgctctttga accacacagc aaggcaggga 901 ccgtgttgtt cagccagggg gacaagggca cttcgtggta cattatctgg aagggatctg 961 tcaacgtggt gacccatggc aaggggctgg tgaccaccct gcatgaggga gatgattttg 1021 gacagctggc tctggtgaat gatgcacccc gggcagccac catcatcctg cgagaataca 1081 actgtcattt cctgcgtgtg gacaagcagg acttcaaccg tatcatcaag gatgtggagg 1141 caaagaccat gcggctggaa gaacatggca aagtggtgct ggtgctggag agagcctctc 1201 agggcgccgg cccttcccga cccccaaccc caggcaggaa ccggtataca gtgatgtctg 1261 gcactccaga taagatccta gagcttctgt tggaggccat gggactagat tccagtgctc 1321 atgacccaaa agaaacattc ctcagcgact tcctcctgac ccacagggtc ttcatgccca 1381 gcgcccaact ctgcgctgcc cttctgcacc acttccatgt ggagcctgcg ggtggcagcg 1441 agcaggagcg cagcacctac gtctgcaaca agaggcagca gatcttgcgg ctggtcagcc 1501 agtgggtggc cctgtatggc tccatgctcc acactgaccc tgtggccacc agcttcctcc 1561 acaaactctc agacctggtg ggcagggaca cccgactcag caacctgctg agggagcagt 1621 ggccagagag gcggcgatgc cacaggttgg agaatggctg tgggaatgca tctcctcaga 1681 tgaaggcccg gaacttgcct gtttggctcc ccaaccagga cgagcccctt cctggcagca 1741 gctgtgccat ccaagttggg gataaagtcc cctatgacat ctgccggcca gaccactcag 1801 tgttgaccct gcagctgcct gtgacagcct ccgtgagaga ggtgatggca gcgttggccc 1861 aggaggatgg ctggaccaag gggcaggtgc tggtgaaggt caattctgca ggtgatgcca 1921 ttggcctgca gccagatgcc cgtggtgtgg ccacatctct ggggctcaat gagcgtctct 1981 ttgttgtcaa cccacaggaa gtgcatgagc tgatcccaca ccctgaccag ctggggccca 2041 ctgtgggctc tgctgagggg ctggacctgg tgagtgccaa ggacctggca ggccagctga 2101 cggaccacga ctggagcctc ttcaacagta tccaccaggt ggagctgatc cactatgtgc 2161 tgggccccca gcatctgcgg gatgtcacca ccgccaacct ggagcgcttc atgcgccgct 2221 tcaatgagct gcagtactgg gtggccaccg agctgtgtct ctgccccgtg cccggccccc 2281 gggcccagct gctcaaaaag ttcattaagc tggcggccca cctcaaggag cagaagaatg 2341 tcaattcctt ctttgccgtc atgtttggcc tcagcaactc gcccatcagc cgcctagccc 2401 acacctggga gcggctgcct cacaaagtcc ggaagctgta ctccgccctc gagaggctgc 2461 tggatccctc atggaaccac cgggtatacc gactggccct cgccaagctc tcccctcctg 2521 tcatcccctt catgcccctt cttctcaaag acatgacctt cattcatgag ggaaaccaca 2581 cactagtgga gaatctcatc aactttgaga agatgagaat gatggccaga gccgcgcgga 2641 tgctgcacca ctgccgaagc cacaaccctg tgcctctctc accactcaga agccgagttt 2701 cccacctcca cgaggacagc caggtggcga ggatttccac atgctcggag cagtccctga 2761 gcacccggag tccagccagc acctgggctt atgtccagca gctgaaggtc attgacaacc 2821 agcgggaact ctcccgcctg tcccgagagc tggagccatg aggaggggct gggactggag 2881 ctggagcagg cacttgcagc cgggaaagcc agggtgtgcc gggccaagat actcacaggc 2941 tggccacagc tgggcaaggc tctccgtgga gtggactcga gtccctggag caggcagtgt 3001 ggaggcagcc atcccctgtg atgactggca gctaaggagg acctcggagt ggaccaaagc 3061 caggaataac gaatgaccaa gggccaagga agggaggaca gagaggcccc aggagtgggt 3121 ggagagtgga gtgcgctggg acgttgtgtg caatagagag gtctccacac cagatgtctt 3181 ccagattctg tgcctctggc tttgttgtcc agccaggcct gcagtttatt ttcacagtgg 3241 acagagagag agagagaggc tgcatgtgtg taccgtgtgt ggcaagggca gggccttggc 3301 ctggggcagg ggcccctgct ttctttccac agctttcttc caacagcagg cagtggggct 3361 gcgggcctga aaaaaaaaaa aaaaaaaaaa aaaa //