LOCUS       CGU50395                1829 bp    mRNA    linear   ROD 18-FEB-1997
DEFINITION  Cricetulus griseus wild type tumor supressor P53 (p53) mRNA,
            complete cds.
ACCESSION   U50395
VERSION     U50395.1
KEYWORDS    .
SOURCE      Cricetulus griseus (Chinese hamster)
  ORGANISM  Cricetulus griseus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Cricetidae; Cricetinae; Cricetulus.
REFERENCE   1  (bases 1 to 1829)
  AUTHORS   Lee,H., Larner,J.M. and Hamlin,J.L.
  TITLE     Cloning and characterization of Chinese hamster p53 cDNA
  JOURNAL   Gene 184 (2), 177-183 (1997)
   PUBMED   9031625
REFERENCE   2  (bases 1 to 1829)
  AUTHORS   Lee,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-MAR-1996) Hyon Lee, Department of Radiation
            Oncology/Biochemistry, University of Virginia School of Medicine,
            Box 440, Charlottesville, VA 22908, USA
FEATURES             Location/Qualifiers
     source          1..1829
                     /organism="Cricetulus griseus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10029"
                     /sex="male"
                     /tissue_type="liver"
     gene            1..1829
                     /gene="p53"
     CDS             106..1287
                     /gene="p53"
                     /function="overexpression rescues p53-mediated G1 function
                     in p53 defective cells"
                     /note="generated by PCR of reverse transcription of mRNA;
                     investigation of G1 checkpoint function of several Chinese
                     Hamster cell lines (CHO, CHOC 400, CHEF 18-1) suggests
                     this is wild type"
                     /codon_start=1
                     /product="P53"
                     /protein_id="AAC53040.1"
                     /translation="MEEPQSDLSIELPLSQETFSDLWKLLPPNNVLSTLPSSDSIEEL
                     FLSENVTGWLEDSGGALQGVAAAAASTAEDPVTETPAPVASAPATPWPLSSSVPSYKT
                     FQGDYGFRLGFLHSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVNSTPPPGTRVRAM
                     AIYKKLQYMTEVVRRCPHHERSSEGDSLAPPQHLIRVEGNLHAEYLDDKQTFRHSVVV
                     PYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDPSGNLLGRNSFEVRICA
                     CPGRDRRTEEKNFQKKGEPCPELPPKSAKRALPTNTSSSPPPKKKTLDGEYFTLKIRG
                     HERFKMFQELNEALELKDAQASKGSEDNGAHSSYLKSKKGQSASRLKKLMIKREGPDS
                     D"
BASE COUNT          434 a          523 c          439 g          433 t
ORIGIN      
        1 ttgggatcag ggggcacctg ggatccgggt ccggaatcta cttcccagcg ggtaacacgc
       61 tcccccctga agacctgaag cctggctgac ttcttgggtg ctgccatgga ggagccacag
      121 tcagacctca gcatcgagct ccctctgagc caggagacat tttcagacct gtggaaacta
      181 cttcctccaa acaatgttct gtccaccttg ccgtcatccg attccattga agagctgttc
      241 ctgtcagaga atgttacagg ctggttagaa gactcaggtg gagcgctcca aggggtggca
      301 gcagcagcag cttctacagc agaagaccct gtaactgaga ctcctgcacc ggtggcctct
      361 gcaccagcca ctccctggcc cctctcatct tctgtcccat cctataaaac cttccagggc
      421 gactatggct tccgtctggg cttcctgcac tcagggacgg ccaaatctgt cacgtgcacg
      481 tactcccctt ccctaaataa gctattttgc cagctggcaa aaacatgccc tgtgcagctg
      541 tgggtcaact ccacccctcc acctggcacc cgtgtccgtg ccatggccat ctacaagaag
      601 ctacaataca tgacagaagt tgtaagacgc tgccctcacc acgagcgctc ctccgaaggc
      661 gatagtttgg ctcctcctca gcatcttatc cgagtggaag gaaatttgca tgccgagtac
      721 ctggatgaca agcaaacatt tcggcacagt gtggtggtac catatgagcc acctgaggtt
      781 ggctctgact gtaccaccat ccattacaac tacatgtgca atagttcctg catggggggc
      841 atgaaccggc ggcccatcct taccatcatc acactggaag accccagtgg taacctgctg
      901 ggacggaaca gctttgaggt tcgtatttgt gcctgtcctg ggagagaccg tcgtaccgag
      961 gaaaaaaatt tccagaaaaa aggagaacct tgcccagagc tgcccccaaa gagtgctaaa
     1021 cgagcattgc ctaccaacac aagctcctct cccccgccaa agaaaaaaac acttgatgga
     1081 gaatatttca cccttaagat ccgaggtcat gagcgcttca agatgtttca agagctgaat
     1141 gaggccttgg aattgaagga tgctcaggct tcaaaggggt cagaggacaa tggtgctcac
     1201 tccagctacc tgaagtccaa gaagggccag tctgcctccc gtcttaaaaa actaatgatc
     1261 aagagagagg ggcctgactc ggactgactt ccttcctagg cctcctgtcc cccaccagca
     1321 acttcccaac ccccacctcc tttcctgaca ttttgtcact tgggtgcttg aaccccggct
     1381 tgggtggatc tgtcatctct gatatctggg gagggtggtg ggatacacca atacaccatc
     1441 ttagctttta ggattctggc catgaggaaa ggaagaaaat tctcaatagg tggtgttgga
     1501 atttacaatt ggccatgtgc aattgtgagg ccccacccaa ttctctaaga aagccatctg
     1561 agtttacttt ctcctgactt gaaagccaca tctataaaat gcagatgagc atacctgact
     1621 tctcagggtt tgttgtgtac ttgtgatact tgtcccttcc gcaccattta ttaccttgtg
     1681 gcctggactc agccccctct gtgagtgctg gttcctggcc ctgttggggg atgggttggt
     1741 agctgccagg tctctgctgg ccagcgaaat cctatccagc cacttgatgg accctggcac
     1801 ctaaaatgaa atttcacccc cccgattcg
//