LOCUS MLU36602 2941 bp mRNA linear VRL 17-OCT-2007 DEFINITION Murine leukemia virus gPr80 envelope polyprotein precursor (env) mRNA, complete cds. ACCESSION U36602 VERSION U36602.1 KEYWORDS . SOURCE Murine leukemia virus ORGANISM Murine leukemia virus Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Ortervirales; Retroviridae; Orthoretrovirinae; Gammaretrovirus. REFERENCE 1 (bases 1 to 2941) AUTHORS Purcell,D.F., Broscius,C.M., Vanin,E.F., Buckler,C.E., Nienhuis,A.W. and Martin,M.A. TITLE An array of murine leukemia virus-related elements is transmitted and expressed in a primate recipient of retroviral gene transfer JOURNAL J. Virol. 70 (2), 887-897 (1996) PUBMED 8551628 REFERENCE 2 (sites) AUTHORS Vanin,E.F., Kaloss,M., Broscius,C. and Nienhuis,A.W. TITLE Characterization of replication-competent retroviruses from nonhuman primates with virus-induced T-cell lymphomas and observations regarding the mechanism of oncogenesis JOURNAL J. Virol. 68 (7), 4241-4250 (1994) PUBMED 8207799 REFERENCE 3 (bases 1 to 2941) AUTHORS Purcell,D.F.J. TITLE Direct Submission JOURNAL Submitted (19-SEP-1995) Damian F.J. Purcell, AIDS cellular biology, Macfarlane Burnet Centre for Medical Research, Yarra Bend Road, PO Box 254, Fairfield, Victoria 3078, Australia FEATURES Location/Qualifiers source 1..2941 /organism="Murine leukemia virus" /mol_type="mRNA" /strain="Mo Ampho" /db_xref="taxon:11786" /lab_host="rhesus monkey (Macaca mulatta)" /note="this is a recombinant virus that arose naturally in a mouse cell line that was being used to produce a gene therapy vector; it subsequently infected a rhesus monkey during the gene therapy protocol" gene 1..2941 /gene="env" misc_feature 1..132 /gene="env" /note="Moloney MuLV sequence" repeat_region 1..72 /gene="env" /note="U5 of LTR" /rpt_type=long_terminal_repeat primer_bind 54..74 /note="U5 PCR primer 1" misc_feature 133..2289 /gene="env" /note="4070A Amphotropic MuLV sequence" CDS 419..2383 /gene="env" /note="this precursor is proteolytically cleaved into gp70SU and p15TM subunits" /codon_start=1 /product="gPr80 envelope polyprotein precursor" /protein_id="AAC54625.1" /translation="MARSTLSKPPQDKINPWKPLIVMGVLLGVGMAESPHQVFNVTWR VTNLMTGRTANATSLLGTVQDAFPKLYFDLCDLVGEEWDPSDQEPYVGYGCKYPAGRQ RTRTFDFYVCPGHTVKSGCGGPGEGYCGKWGCETTGQAYWKPTSSWDLISLKRGNTPW DTGCSKVACGPCYDLSKVSNSFQGATRGGRCNPLVLEFTDAGKKANWDGPKSWGLRLY RTGTDPITMFSLTRQVLNVGPRVPIGPNPVLPDQRLPSSPIEIVPAPQPPSPLNTSYP PSTTSTPSTSPTSPSVPQPPPGTGDRLLALVKGAYQALNLTNPDKTQECWLCLVSGPP YYEGVAVVGTYTNHSTAPANCTATSQHKLTLSEVTGQGLCMGAVPKTHQALCNTTQSA GSGSYYLAAPAGTMWACSTGLTPCLSTTVLNLTTDYCVLVELWPRVIYHSPDYMYGQL EQRTKYKREPVSLTLALLLGGLTMGGIAAGIGTGTTALIKTQQFEQLHAAIQTDLNEV EKSITNLEKSLTSLSEVVLQNRRGLDLLFLKEGGLCAALKEECCFYADHTGLVRDSMA KLRERLNQRQKLFETGQGWFEGLFNRSPWFTTLISTIMGPLIVLLLILLFGPCILNRL VQFVKDRISVVQALVLTQQYHQLKPIEYEP" mat_peptide 419..1792 /gene="env" /product="gp70SU" /note="proteolytic subunit of gPr80; envelope surface glycoprotein" mat_peptide 1793..2380 /gene="env" /product="p15TM" /note="proteolytic subunit of gPr80; envelope transmembrane protein" misc_feature 2282..2941 /gene="env" /note="Moloney MuLV sequence" misc_recomb 2282..2289 /gene="env" /note="minimum recombination region" repeat_region 2425..2869 /gene="env" /note="U3 of LTR" /rpt_type=long_terminal_repeat primer_bind complement(2452..2469) /note="U3 reverse PCR primer 2" repeat_region 2557..2612 /gene="env" /note="different mRNAs either delete or duplicate this repeated U3 enhancer region" repeat_region 2870..2941 /gene="env" /note="R of LTR" /rpt_type=long_terminal_repeat regulatory 2916..2921 /regulatory_class="polyA_signal_sequence" /gene="env" BASE COUNT 773 a 827 c 711 g 630 t ORIGIN 1 acttgtggtc tcgctgttcc ttgggagggt ctcctctgag tgattgacta ccgtcagcgg 61 gggtctttca tttgggggct cgtccgggat cgggagaccc ctgcccaggg accaccgacc 121 caccaccggg agctcactta caggctctct acttagtcca gcacgaagtt tggagaccac 181 tggcggcagc ttaccaagaa caactggacc ggccggtggt gcctcaccct taccgggtcg 241 gcgacacagt gtgggtccgc cgacatcaaa ccaagaacct agaacctcgc tggaaaggac 301 cttacacagt cctgctgacc acccccaccg ccctcaaagt agacggtatc gcagcttgga 361 tacacgcagc ccacgtaaag gcggccgaca ccgagagtgg accatcctct ggacggacat 421 ggcgcgttca acgctctcaa aaccccctca agataagatt aacccgtgga agcccttaat 481 agtcatggga gtcctgttag gagtagggat ggcagagagc ccccatcagg tctttaatgt 541 aacctggaga gtcaccaacc tgatgactgg gcgtaccgcc aatgccacct ccctcctggg 601 aactgtacaa gatgccttcc caaaattata ttttgatcta tgtgatctgg tcggagagga 661 gtgggaccct tcagaccagg aaccgtatgt cgggtatggc tgcaagtacc ccgcagggag 721 acagcggacc cggacttttg acttttacgt gtgccctggg cataccgtaa agtcggggtg 781 tgggggacca ggagagggct actgtggtaa atgggggtgt gaaaccaccg gacaggctta 841 ctggaagccc acatcatcgt gggacctaat ctcccttaag cgcggtaaca ccccctggga 901 cacgggatgc tctaaagttg cctgtggccc ctgctacgac ctctccaaag tatccaattc 961 cttccaaggg gctactcgag ggggcagatg caaccctcta gtcctagaat tcactgatgc 1021 aggaaaaaag gctaactggg acgggcccaa atcgtgggga ctgagactgt accggacagg 1081 aacagatcct attaccatgt tctccctgac ccggcaggtc cttaatgtgg gaccccgagt 1141 ccccataggg cccaacccag tattacccga ccaaagactc ccttcctcac caatagagat 1201 tgtaccggct ccacagccac ctagccccct caataccagt tacccccctt ccactaccag 1261 tacaccctca acctccccta caagtccaag tgtcccacag ccacccccag gaactggaga 1321 tagactacta gctctagtca aaggagccta tcaggcgctt aacctcacca atcccgacaa 1381 gacccaagaa tgttggctgt gcttagtgtc gggacctcct tattacgaag gagtagcggt 1441 cgtgggcact tataccaatc attccaccgc tccggccaac tgtacggcca cttcccaaca 1501 taagcttacc ctatctgaag tgacaggaca gggcctatgc atgggagcag tacctaaaac 1561 tcaccaggcc ttatgtaaca ccacccaaag cgccggctca ggatcctact accttgcagc 1621 acccgccgga acaatgtggg cttgcagcac tggattgact ccctgcttgt ccaccacggt 1681 gctcaatcta accacagatt attgtgtatt agttgaactc tggcccagag taatttacca 1741 ctcccccgat tatatgtatg gtcagcttga acagcgtacc aaatataaaa gagagccagt 1801 atcattgacc ctggcccttc tactaggagg attaaccatg ggagggattg cagctggaat 1861 agggacgggg accactgcct taattaaaac ccagcagttt gagcagcttc atgccgctat 1921 ccagacagac ctcaacgaag tcgaaaagtc aattaccaac ctagaaaagt cactgacctc 1981 gttgtctgaa gtagtcctac agaaccgcag aggcctagat ttgctattcc taaaggaggg 2041 aggtctctgc gcagccctaa aagaagaatg ttgtttttat gcagaccaca cggggctagt 2101 gagagacagc atggccaaat taagagaaag gcttaatcag agacaaaaac tatttgagac 2161 aggccaagga tggttcgaag ggctgtttaa tagatccccc tggtttacca ccttaatctc 2221 caccatcatg ggacctctaa tagtactctt actgatctta ctctttggac cttgcattct 2281 caatcgatta gtccaatttg ttaaagacag gatatcagtg gtccaggctc tagttttgac 2341 tcaacaatat caccagctga agcctataga gtacgagcca tagataaaat aaaagatttt 2401 atttagtctc cagaaaaagg ggggaatgaa agaccccacc tgtaggtttg gcaagctagc 2461 ttaacgccat tttgcaaggc atggaaaaat acataactga gaatagagaa gttcagatca 2521 aggtcaggaa cagatggaac agctgaatat gggccaaaca ggatatctgt ggtaagcagt 2581 tcctgccccg gctcagggcc aagaacagat ggaacagctg aatatgggcc aaacaggata 2641 tctgtggtaa gcagttcctg ccccggctca gggccaagaa cagatggtcc ccagatgcgg 2701 tccagccctc agcagtttct agagaaccat cagatgtttc cagggtgccc caaggacctg 2761 aaatgaccct gtgccttatt tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc 2821 gcttctgctc cccgagctca ataaaagagc ccacaacccc tcactcgggg cgccagtcct 2881 ccgattgact gagtcgcccg ggtacccgtg tatccaataa accctcttgc agttgcatcc 2941 g //