LOCUS DMU14395 6376 bp DNA linear INV 09-MAR-1995 DEFINITION Drosophila melanogaster tyrosine hydroxylase (ple) gene, complete cds. ACCESSION U14395 VERSION U14395.1 KEYWORDS Th; pale. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 638; 1603 to 1747; 1939 to 2098; 2185 to 2317; 2662 to 3521; 3784 to 3950; 4250 to 6376) AUTHORS Birman,S., Morgan,B., Anzivino,M. and Hirsh,J. TITLE A novel and major isoform of tyrosine hydroxylase in Drosophila is generated by alternative RNA processing JOURNAL J. Biol. Chem. 269 (42), 26559-26567 (1994) PUBMED 7929381 REFERENCE 2 (bases 460 to 618; 1616 to 1726; 2682 to 3501; 3804 to 3930; 4270 to 4701) AUTHORS Neckameyer,W.S. and Quinn,W.G. TITLE Isolation and characterization of the gene for Drosophila tyrosine hydroxylase JOURNAL Neuron 2 (2), 1167-1175 (1989) PUBMED 2483109 REFERENCE 3 (bases 1 to 6376) AUTHORS Birman,S. TITLE Direct Submission JOURNAL Submitted (04-SEP-1994) Serge Birman, Biology, University of Virginia, Charlottesville, VA 22903, USA FEATURES Location/Qualifiers source 1..6376 /organism="Drosophila melanogaster" /mol_type="genomic DNA" /strain="Canton S" /db_xref="taxon:7227" /chromosome="3L" /map="65C" prim_transcript 99..6278 exon 99..618 /number=1 gene join(550..618,1616..1726,1958..2077,2204..2296,2681..3502, 3805..3930,4270..4668) /gene="ple" CDS join(550..618,1616..1726,1958..2077,2204..2296,2681..3502, 3805..3930,4270..4668) /gene="ple" /standard_name="pale" /note="Th" /codon_start=1 /product="tyrosine hydroxylase type 2, hypodermal form" /protein_id="AAA62876.1" /translation="MMAVAAAQKNREMFAIKKSYSIENGYPSRRRSLVDDARFETLVV KQTKQTVLEEARSKANDDSLEDCIVQAQEHIPSEQDVELQDEHANLENLPLEEYVPVE EDVEFESVEQEQSESQSQEPEGNQQPTKNDYGLTEDEILLANAASESSDAEAAMQSAA LVVRLKEGISSLGRILKAIETFHGTVQHVESRQSRVEGVDHDVLIKLDMTRGNLLQLI RSLRQSGSFSSMNLMADNNLNVKAPWFPKHASELDNCNHLMTKYEPDLDMNHPGFADK VYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAF QKLQDEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQY VRHVNSPYHTPEPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYW FTVEFGLCKEHGQIKAYGAGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQP IYYVAESFEDAKDKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLVHQMNTEIL HLTNAISKLRRPF" CDS join(550..618,1616..1726,2681..3502,3805..3930,4270..4668) /gene="ple" /standard_name="pale" /note="Th" /codon_start=1 /product="tyrosine hydroxylase type 1, neuronal form" /protein_id="AAA62877.1" /translation="MMAVAAAQKNREMFAIKKSYSIENGYPSRRRSLVDDARFETLVV KQTKQTVLEEARSKANDYGLTEDEILLANAASESSDAEAAMQSAALVVRLKEGISSLG RILKAIETFHGTVQHVESRQSRVEGVDHDVLIKLDMTRGNLLQLIRSLRQSGSFSSMN LMADNNLNVKAPWFPKHASELDNCNHLMTKYEPDLDMNHPGFADKVYRQRRKEIAEIA FAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAFQKLQDEQIFVETR LPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPYHTPEP DSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQ IKAYGAGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKD KFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLVHQMNTEILHLTNAISKLRRPF " intron 619..1615 /note="intron A" exon 1616..1727 /number=2 intron 1728..1958 /note="intron B" exon 1959..2078 /note="first alternatively spliced exon" /number=3 intron 2079..2204 /note="intron C" exon 2205..2297 /note="second alternatively spliced exon" /number=4 intron 2298..2681 /note="intron D" exon 2682..3501 /gene="ple" /number=5 intron 3502..3803 /note="intron E" exon 3804..3930 /number=6 intron 3931..4269 /note="intron F" exon 4270..6278 /note="long last exon, neuronal mRNA" /number=7 exon 4270..5597 /note="short last exon, hypodermal mRNA" /number=7 BASE COUNT 1886 a 1443 c 1261 g 1786 t ORIGIN 1 tgaagcaaac aatcgtcggc aatcggccga aacgttcgtt aacttggccg tcggaatcgg 61 aatctggggg tatttaagcg gcggcaactc gacatgaagc atgcattgat tcgctatcat 121 tcgccctaaa gacttgtgcc cagcctcaag tagtttgctg actctgtttg ttgtaataca 181 atttagctga caaggataat acacatcacc acatcagttt cgagttcgcg aaaggatcca 241 gctaaagttc aaccgatcaa ccatctatat atcccgccgt gaattcgaga gtcgagagtt 301 cttgtccagc tcaattctag acgcaaacag ttcagtacca ggagcgattt tcttgaaaaa 361 caaaaccacc cagccagatc gccaataagc agtgaaagtg tcaacacatt tcgagtgctt 421 attgcaaatc aaacaagaaa agcgtaacca agcacataag caaatagtat tctaagtgtt 481 tttgccaaca ctttgcgtaa atttttgttg ttcaccccaa acgaaaacaa cccaaacaca 541 caaaacaaaa tgatggccgt tgcagcagcc caaaagaacc gcgagatgtt cgccatcaag 601 aaatcctaca gtattgaggt gagtcgaaaa tccagcaaaa catacaattt ccaaatcgaa 661 ttgtaaaaaa aaagaagcaa atgagtgact agatttggtc tacgtgacta tctaaaggtt 721 ttgtgttttc aaaaaaaaac cagttaaccg gccagtagtc gagcccattt ttgtgatccc 781 gcatttcttt ttcgccaatt caatttgacc aaactcaatc ctcggttggc cattaagtca 841 cacctctaag aacaggcggc ccaaatcgaa aggcccaaat cgccaacgga cacaacgggt 901 tgagagttaa gttattattt aacaaataag tgaaagtggc tgcctttggg ccccatgcac 961 ttagcctggc cgaaacagtc gcgcctcatt gttgttgact cgtctctgtt tatgtttatg 1021 ctgcgtccga gcaaaacaaa aaatatgaaa tcaatataaa tgattcaatg attcaatgag 1081 ttggtcatct ttcatcagcc aaagcggtgg ccccaaaaaa aaaaactgaa gaaaacaaac 1141 aaacaaaaaa aaaaaaaaac gagctgacag tgaaaactgc aagtgatgga aacctttttc 1201 cccccatcaa gaaaaagaaa gaaaaaaaac ctttaacgat cgccagttgc atttttttcc 1261 cgccagaatc gcatggggat tttcgatttc tcagtcacat ataatttatc ttcgcacctg 1321 ccgcttcgaa gcggcgacat cgcattaaat taccattcgt ggctttgaat cacaatcaat 1381 acagttccat gaatagccag ctttattcaa agaaaaagat ctgaagacgg cgctttcaca 1441 caccatttta tataatattt tcaaaattgc gcaatactct gctcaaagtc accacccaag 1501 cgtggagccg aagaaagcca ccctggcttg aaggtcaagg caatcgtcta atttccgctc 1561 cacatcctgc cagtgtcact aacacggact tcaatctctt cgcttttgtt tccagaatgg 1621 ctatccatcc cgccgtcgca gcctggtgga tgatgcccgt ttcgagaccc tggtggtcaa 1681 gcagaccaaa caaaccgtcc tcgaggaggc ccgcagcaag gcaaatggta agtgaatagg 1741 gtccaacaag tgggtcacta aaatagctcc aaagagggtt tctatttggg atcaaaaggg 1801 aaattttgca gctagggctt tacttgttga ttaaaaactt aaaaagttgc aatttttatt 1861 tcattttatt cgttttgaca tagatttgcg tttttttctt attcatttta accctttatt 1921 tattatttgc cttcgttttt atttttatga ttttaaagac gattccctgg aagattgcat 1981 tgtgcaggct caggagcaca ttccctccga gcaagatgtg gagctccagg acgagcatgc 2041 caatctggag aacctgccct tggaggaata tgttccaggt taatatccat ttccatttca 2101 attcccatgc cagttactcc tctttctgag cctattatct ttgatttgat tttgattatg 2161 attttcatgg gctttattat tatttttatt tcattcgctt ttagttgagg aggatgttga 2221 gtttgagagc gttgaacagg agcagtcgga gtcgcagtcg caggagccag aaggcaacca 2281 acagccgacc aagaacggtg agcagggggt tctagaatcc agcagccaac cataagtagt 2341 acttaacttc tgagaggggc ttttgaaaag cgtgcgacat tgatttaagt gcttaatatg 2401 ataaagtgcc agggcagagg aaaagcactc agccacacgg acaattgtga gtgggcgcgc 2461 tcgctcgctc tctctctctc tctctctctc tctgtggaaa tgtcgcattt ccctttttca 2521 tttgttacgc tcgacttaat acaagtacga aatgcgtttg cctggcaacc gtctcactgc 2581 cactgccacg tagctcgctt atcgtttacg tgaccctaag ccttggaaga ttgcatcctt 2641 aaccatcaca ttatccccgc ttttttttgg cccttttgca gattacggtc tcaccgagga 2701 cgagattttg ttggccaatg ccgcctccga atcctcggat gccgaggctg ccatgcagag 2761 tgccgctttg gtggtccgcc tcaaggaggg catctcctcc ttgggtcgca tcctcaaggc 2821 catcgaaacc ttccacggca ccgtccagca tgtggagtcc cgtcagtcgc gcgtggaggg 2881 cgtggaccac gatgtcctca tcaagttgga catgacccgt ggcaatctgc tgcagctgat 2941 ccgctccctc aggcagtcgg gctccttcag cagcatgaat ctgatggccg acaataactt 3001 gaatgtcaag gctccgtggt tccccaagca cgcctccgaa ttggataact gcaaccatct 3061 gatgaccaag tacgagcccg atttggacat gaaccacccc ggattcgccg acaaggtata 3121 ccgccagcgt cgcaaggaaa ttgccgagat cgcattcgcc tacaagtacg gagacccgat 3181 cccattcatc gactactccg atgtggaggt caagacctgg cgctcggtgt tcaagaccgt 3241 tcaggatctg gctcccaagc acgcctgtgc cgagtaccgg gccgccttcc agaagctcca 3301 ggatgagcag atcttcgtgg agacccgtct gccccagttg caggagatgt ccgactttct 3361 gcgcaagaac accggattct ctctccgtcc tgccgccggt cttttgactg cccgggactt 3421 ccttgcctcc ttggccttcc gcatcttcca gagcacccag tatgtgcgcc acgttaactc 3481 accataccac acccccgagc cgtaagtatc tatcatcata ttttactagg gggttaaaat 3541 cacttcaaaa agggggagaa aaaggctctt tgtcctagcc taattgcatt tgcctgcctg 3601 cctgccgcct gcctctgtgt gtgtgtgtgt gtgggtggct gggtttcctt ttccgctttt 3661 cccaagcaac ttttgtcgcc tggaacacag gcaaattggc tacaggaact gcggcaggct 3721 gcccagctca tttaaccagg ctaattgcct tatgccagca cattttccac acttttaaca 3781 agcattattc tatgccatta cagcgactcc attcacgagc tgctgggtca catgcccctg 3841 ctggccgatc ccagcttcgc ccagttctcg caggagattg gactggcctc gctgggtgcc 3901 tccgacgaag aaatcgagaa gctgtccacg gtgagttgat tttctaattg agttgcaatg 3961 taacgacctt agactcaagt gcagctatga cgcagctagt tttttttcgc aaccaagatc 4021 attgtttagt cactgtcaaa gtcgaagagg aaaagtgaac ttcaatgcca gaataatttt 4081 tttcttttta ttcatatagt ttacagatac aatttaatgc atttcaaaac acttaattgt 4141 gattttaaat aagtttttaa gttcagaaaa ccttgatctt ataagtcata caacttcctg 4201 ccctatctgg ctttgctttt attttcctta ttatttactc attggttcct taccattcca 4261 tttcttcagg tatactggtt cactgttgag ttcggtctct gcaaggaaca tggtcagatc 4321 aaggcctacg gtgctggact cctgagctcc tacggtgagc tgctccatgc catcagcgac 4381 aagtgcgagc accgcgcctt cgagcccgca tccaccgccg tgcagcccta ccaggatcag 4441 gagtaccagc ccatctacta tgtggccgag agcttcgagg atgccaagga caagttccgt 4501 cgctgggtga gcaccatgtc gcgtccattc gaggtgcgtt tcaacccgca caccgagcgc 4561 gtcgaggtgc tggactccgt ggacaagctg gagactctgg tgcaccagat gaacacggag 4621 attttgcatc tgaccaacgc catctccaag ttgcgacgcc cgttttaagt ggatgggggg 4681 gagatatatg tatgatatat agaagcaccc aaaaacatcg cccaaaaaac acaccagcca 4741 cccctaccac ccaaacatac acatacaggt gcaacggtct catttataca aattaatttt 4801 aaattgacat accgcacaat ccctcgtaca cgtaatcctt aaaccaaaat taaggcatcg 4861 cgcattattt tttatttttt gtttattgtt ttttgtttaa tttttattta attgtcatcg 4921 aaaagttgta attgtcgaat cgcgcacatg gtaaaaaaca caaaaatcaa gcatatttat 4981 ttgttgatca cccgatacac cacccaacct gcatatttat cacctattat tggaccaaaa 5041 aatctttaga cgtttaagtg atgtgaaaac aaagccaagc caagccaagc aaagcaaagc 5101 gaattaagtg aagtgaaaag ctgggaaagc aaagttcaga tacatccgca cttagtaggc 5161 aaagtaccac acaaaaaccg attgtatact cagacaaaaa ttgtttttgt attattatta 5221 tcttcatttt gcctctcaca atatttacct agactatata gacacgcgat atagtattcc 5281 cggtatagga agcttcattt agagagagta tttctaaaca aaaatgatat agatacaaca 5341 atcgagcaag gaacaaatgg aaaacaaaca aaaaaaaaaa cggaaaagat aaaaaatgaa 5401 atggaaaaca aaatagaatt ttcttacatt gtacaataac tgtaaacgac aatattacta 5461 ttgtgtacta ttattattat tatctattat tatacttatg actattacgt attgtattgt 5521 aggtatgtag agtttaaaca ttattatttt atttaagttt tgtgtattaa taaaattaaa 5581 aatgcaattg aaaaataatt actctttggt ttttcatttg attatcttct ttggcaattc 5641 gaaactctaa agtctgaatc tgtttaggga acattttatg acatcaaaat ggaatattta 5701 tttaaaatta atgagtagaa tcgaggaata tgataaatat atttatgggt gagaagaagt 5761 gaatctcatg tgaactaaaa tcgagctatg tagaaaatat ttcacaaatt tgatgaaatt 5821 atataaaata acgaaaaacc ttggaccaat acatatgtat tattataaag taattaaaat 5881 caaaatattt caaagtaaac aaagtaaaac attgggatca agaatattac atatttatag 5941 ttaacgtagc atggaatttt attgttattg ttcgatgtat tgtagttgca attggatcga 6001 aagccaacca agtgttaaca tttctgcaag caattagcca aactaattac taattatatt 6061 cgcacataaa tctatatata taatcaactt aaagcgcagt tggtccccaa gccaggcttc 6121 gttggttctg aaaaattcaa taaaattata tgtttgaatg gagcacaaaa cgtgcagata 6181 tcgtaaatat atatataaat atatatatat acacattctt ctctatatgt acatttaatc 6241 gctattatat gaataaagtt gaaatcgttt aaacttgaaa acgaactaaa attctgggag 6301 gggctgtggc acgcccccac aattttacaa tgattttttt attttttatt tgcacacctt 6361 gacttgccag agatcc //