LOCUS       HSU12789                1542 bp    mRNA    linear   HUM 23-MAR-1996
DEFINITION  Human clone HSH1 HMG CoA synthase mRNA, partial cds.
ACCESSION   U12789
VERSION     U12789.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1542)
  AUTHORS   Boukaftane,Y., Duncan,A., Wang,S., Labuda,D., Robert,M.F.,
            Sarrazin,J., Schappert,K. and Mitchell,G.A.
  TITLE     Human mitochondrial HMG CoA synthase: liver cDNA and partial
            genomic cloning, chromosome mapping to 1p12-p13, and possible role
            in vertebrate evolution
  JOURNAL   Genomics 23 (3), 552-559 (1994)
   PUBMED   7851882
REFERENCE   2  (bases 1 to 1542)
  AUTHORS   Mitchell,G.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUL-1994) Grant A. Mitchell, Centre de Recherche,
            Hopital Ste-Justine, 3175 Cote Ste-Catherine, Montreal, Quebec H3T
            1C5, Canada
FEATURES             Location/Qualifiers
     source          1..1542
                     /db_xref="H-InvDB:HIT000218105"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p12-13"
                     /clone="HSH1"
                     /tissue_type="liver"
                     /clone_lib="human liver cDNA, Kwok et al., Biochemistry
                     (1985) 24: 556-561"
     CDS             <1..1094
                     /note="Residue 1 aligns with residue 146 in the rat
                     mitochondrial HMG CoA synthase, Ayte et al., PNAS (1990)
                     87:3874-3878, Swiss-Prot Accession Number P22791"
                     /codon_start=3
                     /product="HMG CoA synthase"
                     /protein_id="AAA92674.1"
                     /translation="MELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSSWDGRY
                     AMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYDFYKPNLA
                     SEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIFHTPFC
                     KMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDM
                     FDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFF
                     SFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPP
                     GDTNSLFPGTWYLERVDEQHRRKYARRPV"
     polyA_site      1542
                     /note="17 A nucleotides"
BASE COUNT          381 a          398 c          363 g          400 t
ORIGIN      
        1 tcatggaact cttccaggat tcaggcaata ctgatattga gggcatagat accaccaatg
       61 cctgctacgg tggtactgcc tccctcttca atgctgccaa ctggatggag tccagttcct
      121 gggatggtcg ttatgccatg gtggtctgtg gagacattgc cgtctatccc agtggtaatg
      181 ctcgtcccac aggtggggcc ggagctgtgg ctatgctgat tgggcccaag gcccctctgg
      241 ccctggagcg agggctgagg ggaacccata tggagaatgt gtatgacttc tacaaaccaa
      301 atttggcctc ggagtaccca atagtggatg ggaagctttc catccagtgc tacttgcggg
      361 ccttggatcg atgttacaca tcataccgta aaaaaatcca gaatcagtgg aagcaagctg
      421 gcagcgatcg acccttcacc cttgacgatt tacagtacat gatctttcat acaccctttt
      481 gcaagatggt ccagaagtct ctggctcgcc tgatgttcaa tgacttcctg tcagccagca
      541 gtgacacaca aaccagctta tataaggggc tggaggcttt cggggggcta aagctggaag
      601 acacctacac caacaaggac ctggataaag cacttctaaa ggcctctcag gacatgttcg
      661 acaagaaaac caaggcttcc ctttacctct ccactcacaa tgggaacatg tacacctcat
      721 ccctgtacgg gtgcctggcc tcgcttctgt cccaccactc tgcccaagaa ctggctggct
      781 ccaggattgg tgccttctct tatggctctg gtttagcagc aagtttcttt tcatttcgag
      841 tatcccagga tgctgctcca ggctctcccc tggacaagtt ggtgtccagc acatcagacc
      901 tgccaaaacg cctagcctcc cgaaagtgtg tgtctcctga ggagttcaca gaaataatga
      961 accaaagaga gcaattctac cataaggtga atttctcccc acctggtgac acaaacagcc
     1021 ttttcccagg tacttggtac ctggagcgag tggacgagca gcatcgccga aagtatgccc
     1081 ggcgtcccgt ctaaaggtgt tctgcagatc catggaaagc ttcctgggaa agtatgctag
     1141 cagagcttct ccccgtgaat catattttta agatcccact cttagctggt aaatgaattt
     1201 gaatcgacat agtagcccca taagcatcag ccctgtagag tgaggagcca tctctagcgg
     1261 gcccttcatt cctctccatg ctgcaatcac tgtcctgggc ttatggtgct atgcactagg
     1321 ggtcctttgt gaaagagcaa gatggagcaa tggagagaag acctcttcct gaatcactgg
     1381 actccagaaa tgtgcatgca gatcagctgt tgccttcaag atccagataa actttcctgt
     1441 catgtgttag aactttatta ttattaatat tgttaaactt ctgtgctgtt cctgtgaatc
     1501 tccaaatttt gtaccttgtt ctaagctaat atatagcaat ta
//