LOCUS MW646509 17373 bp DNA linear VRT 14-JUL-2021 DEFINITION Bombina bombina voucher BomBom_A_KQ02 mitochondrion, partial genome. ACCESSION MW646509 VERSION MW646509.1 KEYWORDS . SOURCE mitochondrion Bombina bombina (fire-bellied toad) ORGANISM Bombina bombina Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Bombinatoridae; Bombina. REFERENCE 1 (bases 1 to 17373) AUTHORS De Cahsan,B., Westbury,M.V., Paraskevopoulou,S., Drews,H., Ott,M., Gollmann,G. and Tiedemann,R. TITLE Genomic consequences of human-mediated translocations in margin populations of an endangered amphibian JOURNAL Evol Appl 14 (6), 1623-1634 (2021) PUBMED 34178108 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 17373) AUTHORS De Cahsan,B., Westbury,M.V., Paraskevopoulou,S., Drews,H., Ott,M., Gollmann,G. and Tiedemann,R. TITLE Direct Submission JOURNAL Submitted (22-FEB-2021) Globe Institute, University of Copenhagen, Oster Farimagsgade 5, Copenhagen 1353, Denmark COMMENT ##Assembly-Data-START## Assembly Method :: BWA v. v0.7.15 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..17373 /organism="Bombina bombina" /organelle="mitochondrion" /mol_type="genomic DNA" /specimen_voucher="BomBom_A_KQ02" /db_xref="taxon:8345" /geo_loc_name="Germany" /collection_date="2016" /collected_by="G.Gollmann" rRNA <1..921 /product="12S ribosomal RNA" tRNA 922..989 /product="tRNA-Val" /anticodon=(pos:951..953,aa:Val,seq:tac) rRNA 990..2589 /product="16S ribosomal RNA" tRNA 2590..2664 /product="tRNA-Leu" /anticodon=(pos:2625..2627,aa:Leu,seq:taa) gene 2665..3626 /gene="ND1" CDS 2665..3626 /gene="ND1" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:3625..3626,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="QXL58389.1" /translation="MFIILTHLVNFLLYIIPVLLAVAFLTLVERKVLGYMQLRKGPNI VGPTGILQPVADGLKLFLKEPIRPSTSSQLLFMITPTMALALAMFIWTPLPMPFSLVE INLSILFILAISSLTVYSILGSGWASNSKYALIGALRAVAQTISYEVTLALILLCLIM FTGNFTLFSFNTSQEWIWLIAPGWPMAMMWYISTLAETNRAPFDLTEGESELVSGFNV EYAGGPFALFFLAEYANILMMNTLSAILFLGSYYFIIQSPIILMIKATALSMLFLWVR ASYPRFRYDQLMHLVWKNFLPITLALTIWHIALPISTAGLPPQI" tRNA 3627..3695 /product="tRNA-Ile" /anticodon=(pos:3658..3660,aa:Ile,seq:gat) tRNA complement(3697..3766) /product="tRNA-Gln" /anticodon=(pos:complement(3733..3735),aa:Gln,seq:ttg) tRNA 3767..3835 /product="tRNA-Met" /anticodon=(pos:3797..3799,aa:Met,seq:cat) gene 3836..4880 /gene="ND2" CDS 3836..4880 /gene="ND2" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:4880,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="QXL58390.1" /translation="MSPLVLSILMSSLALGTVITASSHHWLLAWMGLEINTLAIIPLM AKMHHPRAIEAATKYFITQAAASAVILFSSTTNAWTTGEWDIMNLTSHLSTTTLLMAI LMKLGVAPFHFWLPEVLQGIDLTTGLILSTWQKLAPMALLIQVSPNLNPQLLFISGII STMIGGWGGLNQTQLRKIMAYSSIAHLGWMMAALTISPQLTTLNLIIYIIMTTAMFLT LKMFSSTKISTLSSSWQKTPTLAAMSTLTLLSMGGLPPLTGFMPKWLILQEMTKQSAT ILATMMALSALLSLFFYIRLTYTMTLTTHPNTTPSTQVWRFSTTQPKLLLMASATASV ALLPSTPLLFSILP" tRNA 4881..4950 /product="tRNA-Trp" /anticodon=(pos:4911..4913,aa:Trp,seq:tca) tRNA complement(4951..5020) /product="tRNA-Ala" /anticodon=(pos:complement(4987..4989),aa:Ala,seq:tgc) tRNA complement(5021..5093) /product="tRNA-Asn" /anticodon=(pos:complement(5058..5060),aa:Asn,seq:gtt) rep_origin 5094..5119 /note="L-strand origin of replication" tRNA complement(5120..5185) /product="tRNA-Cys" /anticodon=(pos:complement(5155..5157),aa:Cys,seq:gca) tRNA complement(5187..5255) /product="tRNA-Tyr" /anticodon=(pos:complement(5222..5224),aa:Tyr,seq:gta) gene 5257..6810 /gene="COX1" CDS 5257..6810 /gene="COX1" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit I" /protein_id="QXL58391.1" /translation="MAITRWLFSTNHKDIGTLYLVFGAWAGMVGTALSLLIRAELSQP GTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSF WLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILG AINFITTTINMKPPAMSQYQTPLFVWSVLITAILLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPVLYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWA MMSIGLLGFIVWAHHMFTVDLNVDTRAYFTSATMIIAIPTGVKVFSWLATMHGGTIKW DAAMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG FVHWFPLFTGYTLHETWTKIHFGVMFAGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLW NTVSSVGSLISLVAVIMMMFIIWEAFSTKREVLLTELTSTNIEWLHGCPPPYHTFEEP AFVQTPYRA" tRNA complement(6811..6881) /product="tRNA-Ser" /anticodon=(pos:complement(6847..6849),aa:Ser,seq:tga) tRNA 6885..6951 /product="tRNA-Asp" /anticodon=(pos:6913..6915,aa:Asp,seq:gtc) gene 6954..7641 /gene="COX2" CDS 6954..7641 /gene="COX2" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:7641,aa:TERM) /transl_table=2 /product="cytochrome c oxidase subunit II" /protein_id="QXL58392.1" /translation="MAHPAQLGFQDAASPIMEELLHFHDHALMAVFLISTLVLYIITT MMTTKLTNTNAMDAQEIEMVWTIMPAIILIVIALPSLRILYLMDEISDPHLTVKAIGH QWYWSYEFTNYEDLAFDSYMIPTQDLSPGQFRLLEVDNRMVVPMESPTRMLITAEDVL HSWAVPALGIKTDAIPGRLNQTSFIATRPGVFYGQCSEICGANHSFMPIVVEAVPLKT FENWSSSMLET" tRNA 7642..7714 /product="tRNA-Lys" /anticodon=(pos:7675..7677,aa:Lys,seq:ttt) gene 7716..7883 /gene="ATP8" CDS 7716..7883 /gene="ATP8" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="QXL58393.1" /translation="MPQLNPGPWFAILIFSWLILLTIFPQKVTKHLSMNEPATQNTEK SKPTPWTWPWA" gene 7874..8557 /gene="ATP6" CDS 7874..8557 /gene="ATP6" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="QXL58394.1" /translation="MSLSFFDQFMSPFLLGIPLIAVAILMPSLLIPTPSSRWINNRLI TLQTWFINNFTKQIFSPINLGGHKWALMLTSLMLFLISMNLLGLLPYTFTPTTQLSLN MGLAVPLWLATVLIGLRNQPTVALGHLLPEGTPTLLIPVLIIIETISLFIRPLALGVR LTANLTAGHLLIQLIATAAFVLLPIMPTVSIITSIILFLLTILEIAVAMIQAYVFVLL LSLYLQENV" gene 8561..9344 /gene="COX3" CDS 8561..9344 /gene="COX3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9344,aa:TERM) /transl_table=2 /product="cytochrome c oxidase subunit III" /protein_id="QXL58395.1" /translation="MAHQAHAYHMVDPSPWPLTGAVAALLLTSGLAMWFHFDSLSLLY LGLIIMVLTMLQWWRDVIREGTFQGHHTPPVQKGLRYGMILFITSEVFFFIGFFWAFY NSSLAPTLELGECWPPAGITPLNPFEVPLLNTAVLLASGVTVTWAHHSIMQGDRKEAI QSLGLTILLGLYFTALQAMEYYEAPFTIADGVYGSTFFVATGFHGLHVIIGSLFLAVC LIRQIQFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS" tRNA 9345..9416 /product="tRNA-Gly" /anticodon=(pos:9378..9380,aa:Gly,seq:tcc) gene 9417..9759 /gene="ND3" CDS 9417..9759 /gene="ND3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9759,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="QXL58396.1" /translation="MIHTILLTASAVATLLALISFWLPQISPDTEKLSPYECGFDPLG SARLPFSMRFFLVAILFLLFDLEIALLLPTPWAIQLDFPMLTIFWSFLILTLLTLGLI YEWLQGGLEWAE" tRNA 9760..9828 /product="tRNA-Arg" /anticodon=(pos:9790..9792,aa:Arg,seq:tcg) gene 9829..10125 /gene="ND4L" CDS 9829..10125 /gene="ND4L" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="QXL58397.1" /translation="MTLTHFSFCSAFILGLTGLAFHRTHLLSALLCLEGMMLSLFLGL SLWSSQMPSVSFSLAPMLILTFSACEAGTGLALLVATTRTHGTDNLHNLNLLQC" gene 10119..11496 /gene="ND4" CDS 10119..11496 /gene="ND4" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:11496,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="QXL58398.1" /translation="MLKIILPSLMLIPLIWLSPSKWLWTLSTIHSLVIALISLTWFAS PTETVHFTTHILSVDQLSSPLLILSCWLLPIMIIASQNHLATEPLNRQRTYITTLTSL QIALIVAFSATELILFYITFEITLIPTLMLITRWGNQAERLNAGIYFLFYTLMGSLPL LVALLSLQNSEGTLSTLLMQLDTPTMPTSWANKAWWLACLIAFMVKMPLYGAHLWLPK AHVEAPIAGSMVLAAILLKLGGYGIMRVSMLLPASMNDLAYPFIILALWGVIMTSSIC LRQTDLKSMIAYSSVSHMGLVIAAAMIQTPWSFSGAIVLMVAHGLISSALFCLANTNY ERTHSRTLLLSRGMQIILPLMGAWWLLSNLANMALPPSPNLMGELSVMVAMFNWSNWT ILLTGSGTLLTAAYSLYMFLMTQRGPTPQHLTALNPTHTREHTLMLLHLLPIMPLIMN PSLIWGAFS" tRNA 11497..11564 /product="tRNA-His" /anticodon=(pos:11526..11528,aa:His,seq:gtg) tRNA 11565..11631 /product="tRNA-Ser" /anticodon=(pos:11590..11592,aa:Ser,seq:gct) tRNA 11632..11704 /product="tRNA-Leu" /anticodon=(pos:11665..11667,aa:Leu,seq:tag) gene 11705..13513 /gene="ND5" CDS 11705..13513 /gene="ND5" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="QXL58399.1" /translation="MNLPLIFSSSLLLTITTLLLPIFFSLLLKQPAAHLTKSSVKTAF FISLIPLFIFLDQGTESIVTNFHWITINTYDINVSFKFDLYSTVFIPIALFVTWSILE FAVWYMSADPLIDRFFKYLLTFLVTMLILVTANNLFQLFIGWEGVGIMSFLLIGWWYS RADANTAALQAVIYNRVGDIGLILSMVWLSVHLNSWELHQIFSLQNDDMTLPILGFIL AATGKSAQFGLHPWLPAAMEGPTPVSALLHSSTMVVAGIFLLIRIHPTMENNQLMLTT CLCLGALTTLFTAACALTQNDIKKIVAFSTSSQLGLMMVTIGLNCPQLAFLHICTHAF FKAMLFLCSGSIIHSLNDEQDIRKMGGLQHSLPITTTCLTIGSLALMGTPFLAGFFSK DAIIEALNTSPANSWALVLTILATSFTAIYSFRIIYFASMNHPRSLPLSPINENNHLI FNPIKRLAWGSIIAGLILTSNLTLIKTPVLTMPFLAKLAALLVTIIGFTIAFDLSNMT MKQSKTPSRTHTFSNLLGFYPNIIHRMMPKISLNMGQVISTHLLDVSWYEKAGPKGIT DQQLPMIKTTTNIQQGLIKTYLTIFLLTTAAAVMLT" gene complement(13509..14018) /gene="ND6" CDS complement(13509..14018) /gene="ND6" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="QXL58400.1" /translation="MIYLVSFFLVGLVLGLVAVASNPSPYYAALGLVMAAGAGCCVIV NFGASFLSLVLFLIYLGGMLVVFAYSAALTAEPYPEAWGSWSVAGYVLVYLLLVVAGY YAVGGLTFSEFLLGGGAVVVRGDLVGVSLMYSSGGLMLIVGGWILLLTLFVVLELTRG HHRGGLRAV" tRNA complement(14019..14087) /product="tRNA-Glu" /anticodon=(pos:complement(14055..14057),aa:Glu,seq:ttc) gene 14096..15236 /gene="CYTB" CDS 14096..15236 /gene="CYTB" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15236,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="QXL58401.1" /translation="MAPNLRKSHPLVKIINGSFIDLPAPSNISAWWNFGSLLGICLII QILTGLFLAMHYTADTTMAFSSVAHICRDVNYGWLIRNLHANGASFFFICIYFHIGRG IYYGSFLFKETWNIGVVLLFLVMATAFVGYVLPWGQMSFWGATVITNLLSAVPYVGTT LVQWIWGGFSVDNATLTRFFAFHFLLPFVIAGATILHLLFLHETGSNNPTGLNSNTDK IPFHPYFSYKDLLGFLLMLTMLTLLAMFSPNLLGDPDNFTPANPLVTPPHIKPEWYFL FAYAILRSIPNKLGGVLALVFSILILALLPLLHTAKQRSMMFRPITQIIFWSLIADAL ILTWIGGQPVEEPFILIGQVASVIYFFIFLILLPASGWLENKLLSW" tRNA 15237..15305 /product="tRNA-Thr" /anticodon=(pos:15267..15269,aa:Thr,seq:tgt) tRNA complement(15330..15398) /product="tRNA-Pro" /anticodon=(pos:complement(15366..15368),aa:Pro,seq:tgg) D-loop 15399..17373 /note="control region" BASE COUNT 5212 a 4642 c 2724 g 4795 t ORIGIN 1 ccctgcctta cagtcaattg tagctaaatt tacacatgca agtatccgca ccccagtgaa 61 aatgcccttg cattctccac acagagaaca aggagctggt atcaggcacc acttatgccc 121 atgacacctt gctctgccac acccccaagg gaactcagca gtgataaact ttgaatataa 181 gcgaaagctt gaatcagtta tagctcacag agtcggtcaa tctcgtgcca gccgccgcgg 241 ttatacgaaa gactcaaact gacagaaatc ggcgtaaaga gtgattaagg aaaacgccac 301 ccagagccaa acagctacta agccgtcgca cgcattagta agctagaaga actttactaa 361 agtagccctg ccacccctga attcacgaca gctaggaaac aaactgggat tagatacccc 421 actatgccta gcctcaaact atgactcaat acaaaatacc atccgcccgg gaactacgag 481 ccccagctta aaacccaaag gacttggcgg tgccccaccc acctagagga gcctgttcta 541 taatcgataa cccccgctta acctcaccac ttcttgccaa taccgcctat ataccaccgt 601 cgccagccca ccccgtgagg gaatagtagg cacaatgata agtcaccaaa acgtcaggtc 661 aaggtgtagc gtatgaagtg ggaagaaatg ggctacattc tctaacctag agcacacgaa 721 aaatcttatg aaattagatt ggaaggagga tttagtagca aaaagaaacg atagtgttct 781 ttttaaactg gccctggggc gcgcacacac cgcccgtcac cctcttcaac taaaactaat 841 agatccccta aaacataaaa caagtacaag aagaggtaag tcgtaacatg gtaagtatac 901 cggaaggtgt gcttggaatc acaagatgta gcttaataaa gcaattcgct tacaccgaat 961 agatgcccgc taaaaccggg ccattttgta gccataattc tagttcaact acaccaccca 1021 tctcaagtca tagaaaacta aaacattacc taactttagt agaggcgata gaacgaaaaa 1081 tagaaacaat agattaagta ccgcaaggga acgatgaaat agaaatgaaa aaactcataa 1141 aagcacaaaa aagcaaagac tcatccttgt accttttgca tcatggtcta acaagtcaac 1201 ccaagcaaaa agactttcag cttgaccccc cgaaactaag cgagctactc ctagacagct 1261 ccaagagcaa acccatctct gtggcaaaag agtgggaaga tctatgagta gtggtgacag 1321 acctaacgag cttagtgata gctggttgct cgagaaaaga acataaattc tgccttaaac 1381 cttagacacc ataaaagtgt actccagctt taagagttat tcaaatgggg tacagctcat 1441 ttgaaacagg aaacaaccta acacctaggt aaagattata ctttttaagg tcttgacaaa 1501 gttggcccaa aagcagccac cttttaagaa agcgtcacag ctcaaacaaa caaccacact 1561 aatacctata actttttctg accctgccaa actatcgagc ccatttatac tagtataaaa 1621 aagtttatgt tagaactagt aacaagaaac gaacttctct taatgcaagt gtacatcaga 1681 ttgaaccact cactgataac taccggccca tcactaaggg aaatgtaaaa acccttcaag 1741 aaaatcctac ataactagcc gttaaactta cacaagagca tctaaagaaa gattaaaagg 1801 tgaggaagga actcggcaaa catgaacttc gcctgtttac caaaaacatc gcctcttgca 1861 acccacatat aagaggtaac gcctgcccag tgaccatgtg ttcaacggcc gcggtattct 1921 gaccgtgcaa aggtagcgta atcacttgtc ttttaaataa agactagtat gaatggcatc 1981 acgagagttc aactgtctcc cccacccaat cagtgaaact gatctccccg tgcagaagcg 2041 gggataaaat cataagacga gaagacccca tggagcttta aactaaaggc actagccctc 2101 aaattacccc taagggtaaa acatttaacc ggctaaagtg acccaccgtt ttcggttggg 2161 gcgaccacgg agaaaaacag atcctccgag atgaaaggga taacccttag ccaagaccaa 2221 caattctaag caatagaacg tctaacacac tgatccaatc aaattgatca acgaaccaag 2281 ttaccctggg gataacagcg caatctattt tcagagttca tatcgacaaa taggtttacg 2341 acctcgatgt tggatcaggg cctcctagcg gtgcagccgc tgctaagggt tcgtttgttc 2401 aacgattaaa gccctacgtg atctgagttc agaccggagt aatccaggtc agtttctatc 2461 tatgcaagaa ttttcctagt acgaaaggac cagaaaaatg tggccactac cccctctatg 2521 ccacactcca aaccaatgta aacaacttaa ttaaatagga gcttgcaacc aagcgcaaga 2581 ttaacgcttg ttagtgtggc agagcccggt aaatgcaaaa gacctaagtc ctttgaccca 2641 ggggttcaac tcccctcact aactatgttt attattctta ctcaccttgt caattttctg 2701 ctatatatta tcccagttct tttagccgta gcttttctta cactagttga gcgcaaagta 2761 ttaggataca tacaactccg aaaaggtcct aatattgttg gacccaccgg catcctccaa 2821 ccagtggctg acggactaaa actattctta aaagaaccaa ttcgcccatc cacctcctct 2881 caactgcttt ttataatcac gccaaccata gccctcgccc tagccatatt tatttgaacc 2941 cccctaccaa taccattttc actagtagaa atcaatctta gcattctttt tatcctagca 3001 atctcaagcc tgactgttta ctctatctta ggatctggct gggcctctaa ttcaaaatat 3061 gctctaatcg gagccctgcg agccgttgcc caaaccattt cttacgaagt aacgctggca 3121 ctaattctcc tctgtttaat tatatttaca ggcaacttca ccctgttcag ctttaacaca 3181 tcccaagaat gaatctgact aattgcccca ggatgaccca tagccataat atggtacatc 3241 tcaacactag ccgaaacaaa tcgagccccc tttgatctca ctgaggggga gtccgaacta 3301 gtctctggtt tcaacgtaga gtacgcagga ggaccattcg ccctcttttt tttagcggaa 3361 tacgccaaca ttcttatgat aaacacccta tccgccatcc tcttcctagg ctcatactat 3421 tttattattc aatccccaat tatccttata atcaaagcca ctgcactatc aatattattt 3481 ctctgagttc gagcctccta tccacgcttt cgatatgacc aactcataca cctagtgtga 3541 aaaaacttcc tcccaattac cctggcccta acaatttgac acattgccct tccaatctca 3601 actgcaggcc tcccaccaca aatttaggaa atgtgcccga aagccaagga tcactttgat 3661 agagtgaaac ataggggttc aaaccccctc atttccttag aaagatagga attgaaccta 3721 cccccgagag atcaaaactc tctgtacttc cactatacca cttcctagta aagtcagcta 3781 aaaaagcttt tgggcccata ccccaaacat gttggttaaa ccccctcctt tactaatgag 3841 ccccttagta ctatcaattc ttatatcaag cctggcttta ggaactgtaa ttacagcatc 3901 cagccaccac tggcttctag cctgaatagg ccttgaaatc aacacgctag caattattcc 3961 actcatagct aaaatgcacc accctcgagc aattgaagcc gcaacaaaat attttattac 4021 acaagccgct gcatcagccg tcatcctatt ttctagcact actaacgcat gaactaccgg 4081 agagtgggac atcataaacc taacctcaca cctctcaaca acaaccctgt tgatagccat 4141 cttgatgaaa ctcggggttg caccatttca cttctgactt cctgaggtcc tgcaaggaat 4201 tgacttaaca acaggactca tcttatccac atgacaaaaa ttagccccaa tagcacttct 4261 catccaagtg tccccgaacc ttaacccaca actcctattt atttcaggta tcatttctac 4321 aataattggg ggctgaggcg gacttaatca gacacaactc cgaaaaatta tagcttactc 4381 atcaatcgcc catcttggct ggataatagc agctctaacc atctccccac aacttactac 4441 tcttaacctg attatttata ttatcataac aacagcaata ttcttaacac ttaaaatatt 4501 ctcatcaact aaaatttcaa ccctatcttc atcctgacaa aaaacaccaa cactggccgc 4561 catatcaaca ctcacactcc tctcaatagg aggacttcca cccttaacag gattcatgcc 4621 caaatgactt attcttcaag aaataacaaa acagagtgcc acaatcttag ccaccataat 4681 agctctatct gcattattaa gcttattttt ttacatccga cttacttaca ccataactct 4741 cacgacacac cccaatacga ccccctccac acaagtatga cgcttctcaa ccacccagcc 4801 gaaacttctt ctaatagcat cagcaacagc ctctgttgcc ctcctaccat ctacacccct 4861 cctattctcc attttaccat agaaacttag gataattaga ccaaaagcct tcaaagcttt 4921 cagcaggagt tagaccctcc tagtttctgt taagacttgc aggactctat ccaacatcac 4981 ctgaatgcaa ctcagacact tttattaagc taaagccttt ctagaaagac gggcctcgat 5041 cccgtaaaaa tttagttaac agctaaaagc tctatccagc gagcttcatt ctacttctcc 5101 cgcctgttag agacgggaga agccccggcg agtcttatct cgcttcttga gatttgcaat 5161 ctcatgtgtg gtacaccacg gggcttggta ggaagaggac tttaacctct gttcgcggag 5221 ctacaagccg ccgcctaacc ctcggccatt ctacctgtgg caatcacacg ttgacttttt 5281 tcgacaaatc acaaagatat tggcaccctg tatttagtat tcggtgcctg agccggaatg 5341 gttggaactg ccctcagctt gttgattcga gctgagctga gccagcccgg aaccttgctt 5401 ggggatgacc agatctacaa tgtaattgtc actgcccatg ccttcgtaat aattttcttc 5461 atagttatgc ccatcatgat tgggggattc ggtaactgac tgattcctct aataatcgga 5521 gccccagaca tggcgttccc tcgaatgaat aacatgagct tttgacttct tcccccatca 5581 ttcctcttac tcttagcatc ctcgggcgta gaggccgggg ccggaaccgg ttgaactgtt 5641 tacccgcctt tagcgggaaa cctagcccat gcaggagcat cagtagacct aactattttt 5701 tctttacatc ttgctggggt atcctcaatc ctgggcgcta tcaactttat tacaacaaca 5761 attaacatga aacccccagc aatgtcacag tatcaaacac cattgtttgt gtgatctgta 5821 ctaattacag ctattcttct actcctttca cttcctgttc tggccgcagg aattactatg 5881 cttcttacag accgtaattt aaacacaacc ttttttgacc ctgctggagg gggagatcct 5941 gtactatacc aacacctatt ctgattcttt ggtcacccag aggtatacat tcttatttta 6001 ccaggatttg gtataatttc acatattgtt acttactatt caggtaaaaa agagccattt 6061 ggttacatag gcatagtctg agccatgatg tctattggcc tgctgggctt tatcgtctga 6121 gctcaccaca tatttacagt agacttaaac gtagacactc gagcctactt tacttcggca 6181 acaataatta ttgctatccc aacaggagta aaagtattca gctgattagc cacaatacat 6241 gggggtacaa tcaaatgaga cgcagccatg ctgtgggcac tgggcttcat cttcttattt 6301 acggttgggg gcctgaccgg cattgttcta gccaactcct cactagacat cgtcctccat 6361 gatacgtact acgttgtagc tcacttccac tatgttctat ctataggagc tgtatttgct 6421 attataggcg gatttgtcca ctgatttcca ctatttaccg gctacaccct tcatgagact 6481 tgaacaaaaa ttcattttgg tgtaatattt gcaggggtta atctaacatt cttccctcaa 6541 catttcctag gactagccgg gatgccccga cgctactctg actaccccga tgcctacacc 6601 ctttgaaata cagtctcatc agtgggctcc ctgatctctc ttgtagccgt gatcataatg 6661 atgtttatca tctgagaagc cttttcaaca aaacgtgaag ttctccttac tgaactaact 6721 tcaacaaata ttgaatgact ccacggctgc cctccgccct atcacacatt tgaagaacca 6781 gcatttgtcc agacacccta tcgagcttaa cgagaaggga gggaatcgaa cccccatcaa 6841 ctgatttcaa gtcagtcaca tgaccactct gtcaccttct taataagata ttagtaaata 6901 ttatactgcc ttgtcaaggc agagttgtgg gttgaactcc cgcatatctt aacatggccc 6961 acccagcaca attaggattt caagatgcag catcacccat catagaagaa ctcttacact 7021 tccacgacca tgcattaata gcagtatttt taattagcac actggttctc tatattatca 7081 caacaataat gacaacaaaa ttaactaaca ccaatgcaat agacgcccaa gagattgaga 7141 tggtctgaac aattatgccc gcaatcattc ttattgtcat tgcccttcca tcacttcgta 7201 ttctttattt aatagacgaa attagcgacc cacacctaac agtaaaggcc attggccatc 7261 aatgatactg aagctacgag ttcactaact atgaagacct tgcattcgac tcttacataa 7321 ttccgactca agatttatcc cccggacaat ttcgcctttt agaagtcgac aaccgtatag 7381 tagtcccaat agaatcacca acccgaatac taatcacagc agaagacgtt ctacactcat 7441 gagctgtccc ggcgctgggg attaaaacag atgccatccc agggcgatta aatcaaacat 7501 catttattgc cacacgccca ggtgtcttct acggccaatg ttctgagatc tgcggagcca 7561 accacagctt tataccaatt gtggtcgaag cagtgccatt aaaaaccttt gaaaattgat 7621 cttcatcaat actagagacc tcactaagaa gctaatatgg aatagcaaca gccttttaag 7681 ctgaagacag gtggccccca accaccccta gtgaaatgcc acaactcaac ccaggcccat 7741 gatttgctat cttaatcttc tcatgattaa ttctcctcac aatttttcca caaaaagtaa 7801 caaaacatct atcaataaat gagccagcaa ctcagaacac agaaaaatct aaaccaactc 7861 catgaacctg accatgagcc taagcttctt tgatcaattt atgagcccat tccttctagg 7921 tattccccta attgcagttg caattttaat accaagcctc cttattccaa ccccatcaag 7981 tcgatggatt aataaccgcc ttattacact acaaacatga tttattaata atttcacaaa 8041 acaaatcttt tccccaatta acctcggggg ccacaaatga gccctaatat taacatcctt 8101 aatattattt ttgatctcaa taaaccttct tggactactc ccttacacat tcaccccaac 8161 aactcaacta tcccttaaca tgggactggc tgtcccacta tgactggcca cagtactgat 8221 tggcctgcga aatcaaccaa ctgtagccct aggacacctt cttccggaag gcactcccac 8281 cttactaatc ccggtcctta tcattattga aacaattagt ctatttatcc gcccccttgc 8341 tttaggagta cgactcacag ccaaccttac ggcaggtcac cttcttattc aactaattgc 8401 cacagcagcc tttgtactac tcccaattat acccaccgta tcaattatta catcaattat 8461 cctcttcctc ctgacaattt tagaaattgc agtagccata attcaagctt atgtattcgt 8521 tcttttatta agcctttatc tacaagaaaa cgtataacca atggcccacc aagcacacgc 8581 ctatcacata gtagacccaa gcccttgacc actaacagga gcagtagcag ccctccttct 8641 cacctctgga ctcgccatat gatttcactt tgattctcta agccttcttt acctcggctt 8701 aatcatcata gtcttaacta tacttcaatg atgacgagac gtaattcgtg agggcacatt 8761 ccaaggccac cacaccccgc ccgtccaaaa gggcctgcgc tatggcataa ttctatttat 8821 cacatcagaa gtcttttttt ttattggctt tttctgagcc ttctacaact caagcctggc 8881 tccaaccctg gagctagggg agtgctgacc ccccgcagga attacccctt taaacccatt 8941 cgaggtacca ctgctaaaca ccgcggtctt actcgcttct ggggttacag taacatgggc 9001 ccaccacagc atcatacaag gcgaccgaaa agaagccatc caatcactcg gactgacgat 9061 tcttcttggc ctttatttca cagccctcca agcaatagaa tactacgaag cacctttcac 9121 aattgctgac ggagtttatg ggtcaacatt ctttgttgcc accggcttcc acggcttaca 9181 cgtaattatc ggctccttat tcttagcagt gtgcctaatt cgacagattc agttccattt 9241 tacttccaaa caccattttg ggtttgaggc agccgcctga tactgacact tcgtagacgt 9301 tgtatgacta ttcctctacg tctccatcta ttgatgaggt tcatattttc ttagtattaa 9361 cgccagtaca agtgacttcc aatcacacag cctcggttaa accccgggag aaaataatga 9421 ttcatactat tcttctaaca gcatctgcag ttgcaacact actagccctt atcagcttct 9481 gactaccaca aatttcacct gacacagaaa aactgtcacc ttatgagtgc ggttttgacc 9541 cgctaggctc tgcccgtcta ccattctcaa tacggttctt tcttgttgcc attttatttc 9601 ttctatttga ccttgaaatt gcccttcttc taccaacccc ctgagcaatc caactcgatt 9661 ttccaatatt aacgatcttt tgatcatttt tgatcttaac acttttgacc ctgggactaa 9721 tttatgagtg actacaaggc ggtctagaat gagcagaatg ggtatctagt ccaaacaaga 9781 cagctgattt cggcttagca aattgcggtt aaactccaca gctaccctat gactctcaca 9841 cactttagct tttgtagcgc atttatttta ggtctcacag gactagcctt ccaccgaaca 9901 caccttttat cggccttgct gtgcctggaa ggaataatac tatccctctt ccttggcctt 9961 tcactttgat cttctcaaat gccctctgta tcattttcac tcgccccaat acttatttta 10021 acattctccg cttgcgaggc gggcacggga ttagccctct tagttgccac gacacgaact 10081 cacggcacag ataatctcca caaccttaat cttctgcaat gctaaaaatt atccttccat 10141 ctcttatgct aattccactc atctgacttt ccccttcaaa atgactatga acactctcca 10201 ctattcacag cttagttatt gctttaatta gtttaacatg atttgccagc ccaacagaaa 10261 ctgtccactt tacaacccat attttatcag ttgaccaact gtcgtctcca ttgttaattc 10321 tatcctgctg acttctccca attataatca ttgcaagtca aaatcacttg gcaacagaac 10381 ccctgaatcg acaacgaacc tacattacta cactaacctc actacaaatt gcccttattg 10441 tggccttttc ggccacagaa cttatcctat tttatattac attcgaaatt actctcatcc 10501 caacactcat attgattacg cgctgaggaa atcaagcgga acgcctgaac gcaggcattt 10561 atttcttatt ttatacacta ataggatctc ttccacttct agttgcctta ttatctctac 10621 aaaactctga aggaactcta tcaacactac ttatgcaact tgatacccca accataccaa 10681 cctcttgagc taataaagcc tgatgacttg cctgccttat cgcattcata gtcaaaatgc 10741 cactttacgg ggcccacctt tgactaccaa aagcccacgt agaagcaccg attgctggct 10801 ctatggttct agccgcaatt cttcttaaac taggagggta cggtattata cgagtttcta 10861 tactcctgcc cgcctcgata aacgacctag catacccgtt tattattcta gccctctgag 10921 gtgttatcat aactagctct atctgccttc gtcaaacaga cttaaaatca ataattgcat 10981 actcatccgt cagtcacatg gggttggtaa ttgccgcagc aataatccaa acaccctgaa 11041 gcttcagcgg cgcaattgtt ctaatagtag cccacggact tatctcatct gccttattct 11101 gtttggctaa tacaaactac gaacgcactc acagccgaac tctactactc tcccgaggca 11161 tacaaattat cctgcccctt ataggagcct gatgactact atctaatctt gcaaacatag 11221 ccctcccacc atcccccaat cttataggag agctatccgt tatagtagcc atattcaact 11281 gatcaaactg aaccatctta cttacaggtt caggcaccct actaactgca gcctattccc 11341 tgtatatgtt cctgataacc caacgaggcc ccaccccaca acacctcaca gcccttaatc 11401 caacacacac ccgggagcac actcttatat tactacacct ccttccgatt atacccctaa 11461 ttataaaccc atctttaatt tgaggagcct tctcatgtaa atatagttta gcaaaacact 11521 agattgtgat tctagagtca gaagttaaac ccttcttatt taccgaataa ggttggaaca 11581 ccaagaactg ctaattactt gcccccgcgg ttcaattccg cggcttcttc ggcttttaaa 11641 ggaaaaaagt cgatccgttg gtcttaggaa ccaaaaactc ttggtgcaaa tccaagtaaa 11701 agttatgaat ctcccactta tctttagctc ttctctactg ctaacaatca ccaccctact 11761 tctacctatt ttcttcagcc tcttgttaaa acagccggca gcccacctca caaagtccag 11821 tgtaaaaacc gcatttttta ttagcttaat ccccctattc atcttcctcg accagggtac 11881 agaatctatt gttaccaact ttcattgaat taccattaac acatacgata ttaatgtgag 11941 ctttaaattc gatttatatt caacagtatt tatcccaatt gctctttttg taacatggtc 12001 aattctggaa ttcgcagttt ggtatatgtc agcggacccg ttaatcgacc gatttttcaa 12061 atacttatta acctttttag taacaatact gattcttgtc acagccaaca acctcttcca 12121 gctatttatt ggctgagagg gggtcggaat tatatcattc ctgctaatcg gatgatgata 12181 ctcacgtgca gatgctaaca ctgcagcctt acaagcagtt atctacaacc gggtgggtga 12241 tattggcctt attctaagca tagtctgact ttcagtacac ctaaactcct gagaacttca 12301 tcagattttt tctctacaaa acgacgacat aacccttcca atcctaggct tcattttggc 12361 agcaacaggt aaatcagccc aatttggcct acacccgtga ctccctgccg caatagaggg 12421 ccccacccca gtatcagccc tactccactc aagcactatg gtagtagccg gaatttttct 12481 gctaattcgc attcacccaa ccatggagaa taatcaactt atgctaacca cctgtctttg 12541 tcttggcgct ctaacaacgt tgttcacagc agcttgtgcc ctcacacaaa atgacattaa 12601 aaaaattgtt gccttctcca catcaagcca actgggctta ataatagtaa ccattggact 12661 taactgccca caactagcct tcctgcacat ctgcacccac gctttcttca aagccatact 12721 attcctttgc tcaggatcta ttattcacag cctaaatgac gaacaagata ttcggaaaat 12781 agggggactc cagcactcac tcccaatcac aacaacttgt cttacaattg gcagtcttgc 12841 tttaatgggc acgccctttc tagccggatt cttttctaaa gatgcaatta ttgaagcgct 12901 aaacacctca ccagccaact cctgagcact cgttttaacc atcctagcca cctctttcac 12961 agcaatctac agctttcgca ttatttactt tgcctcaata aatcacccac gctcactgcc 13021 actctcccca attaatgaaa acaaccacct aatctttaac ccaatcaaac gccttgcttg 13081 aggaagcatc attgccggac tcatcttaac atcaaactta accctcatta aaacaccagt 13141 tttaaccata ccttttttgg ctaaattagc cgcactactc gtcaccatta ttggctttac 13201 gatcgcattt gacctttcca acatgaccat aaaacaatca aaaacaccat ctcgtactca 13261 caccttctct aatcttttgg ggttctaccc taatattatt catcgaataa tacccaaaat 13321 ctcattaaat ataggacaag ttatctcaac acacctactc gatgtgagct ggtatgaaaa 13381 agccggcccc aaaggaatta ctgaccaaca actgccaata atcaaaacca ctacaaacat 13441 tcaacaaggc ttaattaaaa cctatttaac aatttttctc ctgacaactg cagcagccgt 13501 tatactcacc taactgcacg aagaccacct cgatggtgcc cgcgagtcaa ctccaaaaca 13561 acaaataaag ttaacaataa aattcaaccg ccaacaatta atattaatcc ccccgacgaa 13621 tatattaatg aaaccccaac caaatcacca cgaacaacca ctgccccgcc cccaagcaaa 13681 aattcactaa aagttaaacc ccctaccgca tagtacccag ccacaaccaa caataaatat 13741 actagaacat acccagcaac agatcaactt ccccatgcct cagggtatgg ctcagcagtt 13801 aaagccgcgg aataagcaaa aaccaccaat attccaccca agtaaattaa aaataaaact 13861 aaggacaaaa aagaggcccc aaaattaaca attacacaac acccagcacc agcagccatc 13921 accaacccaa gagccgcata atatggagac gggttagaag caactgctac caaccccaaa 13981 accaacccca ctaaaaagaa ggataccaaa taaatcatag ttcttacctg gactttaacc 14041 aagaccagag gtctgaaaaa ccaccgttgt ctttcaacta taaaaacccc tcctaatggc 14101 acccaacctc cgaaaatcac accccctagt aaaaattatt aacggatctt ttattgacct 14161 ccccgccccc tccaacattt cagcatgatg aaatttcggc tctttattag gcatctgcct 14221 tattattcaa atcctcactg gcctatttct tgcaatacac tacaccgccg acactacaat 14281 agcattctcg tcagtcgccc acatctgccg ggacgttaac tacggctgac taatccgcaa 14341 cctccatgca aacggagcct ccttcttctt catctgcatt tatttccaca ttggacgcgg 14401 catttattat ggatcatttc tatttaaaga aacctgaaat attggggttg tcttgttgtt 14461 cttagtaata gcaaccgcct ttgtcggcta cgtcctccca tgaggtcaga tgtctttctg 14521 aggagcaact gtcattacaa accttttatc agctgtcccc tacgttggca caacacttgt 14581 ccaatgaatc tgaggcggat tctcagtaga caatgcaacc ctgactcgat ttttcgcctt 14641 tcacttcctt ctcccattcg tcattgccgg agctactatt cttcacctcc tctttcttca 14701 cgaaacagga tcaaacaacc caacaggact taactcaaac acagacaaaa ttccatttca 14761 cccctacttc tcatacaaag acctccttgg cttcctactc atgttaacaa tattaacctt 14821 acttgccatg ttctccccaa acctgttagg agacccggac aacttcaccc ccgccaaccc 14881 gttagtcaca ccccctcaca tcaaacccga gtggtacttc ctgtttgcct atgcaatcct 14941 ccgatcaatt ccaaacaaac taggaggggt actagccctg gtcttctcaa tcctcatcct 15001 tgccctcctg cccctccttc acacagccaa acagcgcagc ataatatttc gaccaattac 15061 ccaaattatc ttctgatcac taattgcaga cgccctaatc ctaacatgaa ttggaggaca 15121 gccagttgaa gagccattta ttcttattgg ccaagtagcc tcagtcatct acttcttcat 15181 cttcctaatc ctactccctg cgtcaggatg gctggaaaat aaactcctaa gttgatgtca 15241 acgtagctta atgaaagcac cggtcttgta aaccgaagag tgaaggttca ccccatcctt 15301 tgacacacac tattggcagt tgttggttat cgaaacagag ggacttaaac ccccatcatc 15361 gacccccaaa gccgacattc tccttaaact atgtttcgca tcttcctcat gaatatcctc 15421 atgaatatcc tcatgaatat cctcatgaat atcctcatga atatcctcat gaatatcctc 15481 atgaatatcc tcatgaatat cctcatgaat atcctcatga atatcctcat gaatatcctc 15541 atgaatatcc tcatgaatat cctcatgaat atcctatgaa tatcctcatg aatatcctca 15601 tgaatatcct catgaatatc ctcatgaata tcctcatgaa tatcctcatt atatgcatat 15661 taatgtgtag ggattatcta tgtataattg agcattcatc tcgtttcctc atgaatatcc 15721 tcattatatg catattaatg tgtagggatt atctatgtat aattgagcat tcatctcatt 15781 tcctcatgaa tatcctcact atttatatat gtcatgtaca cgaccattat atgtacgata 15841 cattcatctc atttcctcat gaatatcctc actatatata tattaatgta taaggactat 15901 atatgtacaa cgagcattca tctcatttcc tcatgaatat tcttatacac ctaaatatct 15961 atgtgtaagg gttatctatg tataattgag cattcatttc atttcctcat gaatatcctt 16021 attattaata taatgtcatg tatacgacca taaatgtgta attgagcata ttgttatctc 16081 atatcatgaa tatgcttaaa cctgactata ctgcgtactt ataacaacct agaaacatga 16141 tattatttat tgaatattat tacaagatca gtatgactga taggaataca aagtacaccc 16201 ttaaccatca aatcgatgcg tacgcccata acataattcg agcagttaca gacatataaa 16261 catgaatgtg tttttccaca tattaagatt aattttacaa cttaagattg agcatgagtg 16321 agagcagcat aaccgtcttt ctcaacatca ctgcataatc taatacgaat aatacaatcc 16381 taacaattga aaaattacca agcttgtaat aaagactaaa aaataagaat acttcaaatt 16441 aattcaacac acgtatatcc cctctgacta ttactacgtc tagtctaaaa gatttgctat 16501 gcttgtgttt ctagatggcc catgctgaag cctaactgat ctcaggtgtt tgggccctaa 16561 tgcgctttcc aaggaacatg gagtgaagag tggcagtcct cacttttcaa aaggccactg 16621 acggatgtga atctatggac acttcccgca acgtagctac gattgctctt taaaaagcct 16681 ccctcctatg ctcatgttcc tagatggccc atgatgaggc ctaactgaga taaatggccc 16741 tcattgtttt ttttggggaa cctttcacca acatctctga gtgggttcaa gcaaacattt 16801 cgggttggac atctcaatgc tcgagttaag aatcaccaac ttaaagggtg ctgaccatgc 16861 tattaatgct agatggacat aaattgcctg ttcgatatga aattttaccc taaatttttc 16921 tccccccggc tctaaattcc tgtcatattc aaaaattggc caaaatttgg cgaaaaatta 16981 cacattttca gaaatttaaa aaacccatac gcagggtttt tggcgttaaa cccccctacc 17041 ccccgtaaga aaccaatagc tcggcatctc ccgtcaaacc ccgaaaccgg gatgcaagaa 17101 actactgtaa ttaactcacg ctgtgtaatt tggactgttc gatggcccta ccaacccact 17161 cccgcatcag aaatctagca catgtgcaga atctttttgg gaatctttaa aacgtatatt 17221 gatataatat gtgtaatttt aacagaaact cctgggcgtg cgctataagg aaattctggt 17281 gtatatatgt atgtgttttt tttttaacgg gaaccccaga gcgtgtgata tggaaattat 17341 ggtgtacgtg tatttacaac tcctaacaca cag //