LOCUS MT899927 16272 bp RNA linear VRL 21-JUN-2021 DEFINITION Grapevine leafroll-associated virus 2 isolate DSJPN3_GLRaV2-01, partial genome. ACCESSION MT899927 VERSION MT899927.1 KEYWORDS . SOURCE Grapevine leafroll-associated virus 2 ORGANISM Grapevine leafroll-associated virus 2 Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes; Martellivirales; Closteroviridae; Closterovirus. REFERENCE 1 (bases 1 to 16272) AUTHORS Fall,M.L., Xu,D., Lemoyne,P., Moussa,I.E.B., Beaulieu,C. and Carisse,O. TITLE A Diverse Virome of Leafroll-Infected Grapevine Unveiled by dsRNA Sequencing JOURNAL Viruses 12 (10), E1142 (2020) PUBMED 33050079 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 16272) AUTHORS Fall,M.L., Xu,D., Lemoyne,P., Ben Moussa,I.E., Beaulieu,C. and Carisse,O. TITLE Direct Submission JOURNAL Submitted (18-AUG-2020) Agriculture and Agri-Food Canada, Research and Development Centre of St-Jean-Sur-Richelieu, 430 Gouin Blvd, St-Jean-sur-Richelieu, Quebec J3B 3E6, Canada COMMENT ##Assembly-Data-START## Assembly Method :: Bowtie2 v. 2.4.1; Velvet de novo assembler v. 1.2.10 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..16272 /organism="Grapevine leafroll-associated virus 2" /mol_type="genomic RNA" /isolate="DSJPN3_GLRaV2-01" /isolation_source="leaves" /host="Vitis vinifera cv. Pinot Noir" /db_xref="taxon:64003" /geo_loc_name="Canada" /collection_date="09-Sep-2019" /collected_by="P. Lemoyene" CDS <1..>7589 /note="conserved domains for papain-like endopeptidases, RNA methyltransferase and viral RNA helicase" /codon_start=2 /product="polyprotein" /protein_id="QOU11796.1" /translation="YMTSLPSLQTCFTQCEFSSLFICLASFQKIKTFLSFLSSVRELA LFSELSTIGFCCEFIRLGVGEHPLFFVSFQCGPLSVCLGCVNGIFAVLNISFPFFDVA SLLMDVGDVVAPTKVRISKREKKLNKRAFSIARAAARIRRSKVGNKEVRISHVQPLPA GCLRFSQNKNRSELIIIGRDVGVVARVKTXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIREVVLRFRVGGDMRF SRFFASTHGCKIVANVRTNTSVWLNCTKVNGEKFSVAIPCSVDYVAMLRYVSGGKFPL VLMSRECYPDGLCYMAHMRYLCAFFCQPFRESDYPLGSWPSVARLKALVLKRFGDEAL NIGVRGYYVSRRAFHCDYDSKYARSLMRLVGHVGGDEVVHSTLASTVVLKPGERARDR PKSISFGSFCCELRYVESVNPDAPRLRSEKVLRKVEPRNGVRTESADVGSNVTRKRDA RIDRKFSHLLAGSVNKVKKRIAAGVLRYRVGGDMDFHNSFLTQAGYHLLVRXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXCLPGYDIIYLDSKFVSRVFDYVVCNCSAVNSKTFEWVWSFIKSSKSRVIISGKI IHKDVNLDLKYVESFAAVMLASGVRSRLASEYLAKNLSHFSGDCSFIEATSFVLREKI RNMTLNFNECLLQLVKRVAFATLDVSFLDLDATMESITDFAECKVAVELEELGCLRAN AENEKIRNLAGDSMAAKLASEIVVDIDAKPVAKHAEHPKSEVSEKKEHAKPGLRGGSK AGVLKEFLGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XAFLLQITKSFSLELIVRNVVRVTHSLSTTATDGVMRSVFSQIISHLLVGNTGNLAYQ IAFLTGVVPLLVKKCVGLIFSMSEDTYSGFIKHGVSEFSFITNILKYLRGQLVDELKA VVQGVFDSNKHLFRDVTQEAIRSTVMQIPTAVVDGLKCAASKVYSGIVGKKTNVGEXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRILIGRIKHRCFSKI FESISLKIHELRTFLLGKKRSGVGVYEFLSEDVAAALSSINECDEIENLIGDGFRDMA DDSLTDMEYFDFSDEFLTSVNGLPCAGLRGGGRRVGMLAILNYVYNSLSVVARAASKN STFTSLIIFSRGLVDRIRNIFSNKESVVELVRKYVKNFLKSRMRGLGLRNEHVVNSFG ELVPLLLRNKLSETFIYRAVPMSKWCWEVCLSAERREKFFALVCLVTLGFPYFARLLG GVVCDKLLSSLRRAYDRVIVFLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGNPLLRGVRRFL RLIAVKLNLRRKRGLRTRNGGYPSQRAVPVIPSNRVTNDGCERLSEKMQGVEALRSEL RILEELDAAVVEKLNKRRNREADDSEFSRPMHESTHDVTSFCSKANSVGTALERAVLV EDAVKSEKISRMAKDLVRKGTVSDEEITNTLSDDEAIEEVPISEERDDSPKTVRVSEY LNRLNSSFEFPKPIVVDDNKETGGLTNAVREFYYMQELALFEIHSKLCAYYDQLRIVN FERSMAPCNEDAQLYVRKSGSTIVQGKDVRSNIKDFHDHDFLFDGKISVNRRRRSGNV LYHDNLSFLASNLFLAGYPFSRSFVFTNSSVDILLYEAPPGGGKTTTLI" gap 570..1127 /estimated_length=558 gap 2028..3449 /estimated_length=1422 gap 4162..4658 /estimated_length=497 gap 5174..5308 /estimated_length=135 gap 6118..6534 /estimated_length=417 gap 7590..9077 /estimated_length=1488 CDS <9078..10088 /codon_start=1 /product="RNA-dependent RNA polymerase" /protein_id="QOU11797.1" /translation="TKHSAAQNIMFHRKSINAIFSPIFNEVKNRIMSCLKPNIKFFTE MTNRDFASVVSNMLGDDDVYHIGEVDFSKYDKSQDAFVKSFEEVMYKELGVDEELLAI WMCGERLSIANTLDGQLSFTIENQRKSGASNTWIGNSLVTLGILSLYYDVRHFEALYV SGDDSLIFSRNKISNYADDICADMGFETKFMSPSVPYFCSKFVVMCGHKTFFVPDPYK LFVKLGAVKEDVSMDFLFETFTSFKDLTSDFNDERVIQKLAELVALKYDVQSGNTTLA LSVIHCLRSNFLSFSKLYPRVKGWQVFYTSVKKALFKSGCSLYESYVTPFGHAVTVWD DE" misc_feature 10360..12159 /note="similar to putative heat shock protein 70; HSP70h" gap 10461..12024 /estimated_length=1564 CDS 12086..13690 /note="similar to viral heat shock protein Hsp90" /codon_start=1 /product="63 kDa putative cell to cell movement protein" /protein_id="QOU11798.1" /translation="MSNHSWGSLFKKYYGEADWRKYLSKSIVAHTANIKTLPDVQLYG GRTVKKSEFESVTPRSFEQELGLLMLNERDVGWCKMCGITVEEAMYQITNPEAYPITA EKCDPDVKTEGQKYTMEDVMNFMRRSNLDINDKILAEQCWSLSNXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYCAYIRT YLENTDLYFTSPDRIPLLTGILYDFCKEYNIFYSTYKRNVDNFRFFLTNYMPLISDIF VFQWVKPAPDVRLLFDISAAELTLEVPTLSLVDSQVVIGHVLRFVESYTADPAIDALE EKLDAIMKESXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYKTPNSVGGFEINMK NVEEFFDKIQREVPNVSLRRQFNGARAHEAFKVFKKGNISFKPISRLNIPREFWYLNV DYFRHANRSGLSEEEVLILNNISVDVRKLCAERACSTLPSAKRFSKGHKSSVPSLRQE KNYRDPLITLRNSLHEFRHGSRDRRV" gap 12524..12717 /estimated_length=194 CDS 13653..14324 /note="CPm" /codon_start=1 /product="minor capsid protein" /protein_id="QOU11799.1" /translation="MSSGTGVAIGGSEAIETSGFVLSTRKEAVDKFFNELRNENYSSV DSSRLSDQEVKEVLEKSKESFKSELASTDEHFVYHIIFFLIRCAIISTSDKVKYVGSH KYVVEGKTYTVQDVWVFNMIKGLTKQYKRVNGLRAFCCACEDLYLTVAPAMSERFKTK AIGMKGLPVGKEYLGADFLSGTSRLMSDHDRAVSIVAAKNAVDRSAFTGGERKIVSLY DLGRN" CDS 14412..15008 /note="CP" /codon_start=1 /product="major capsid protein" /protein_id="QOU11800.1" /translation="MELMSDDNLSGLVITDASSLNGADKKLLFAEVIKMLVQKGAPSE GIEIVFGLLLYALAARTTSPKVQRADSDIIFQNTYGDKTVVVTEGDLKKVLEGCAPLN RFTNKLRTFGRTFTEAYIDFCAAYKHKMPQLNAAAKLGIPAEDSYLAADFLGACPKLS ELQQSRKMFASMYALKTEGGVENTPVSNLRQLGRREVM" CDS 15008..15493 /codon_start=1 /product="19 kDa protein" /protein_id="QOU11801.1" /translation="MEICAQNPEALVLLRTNQNTTLLVVKSDDEVNLPKLLICGYLRV SHRGDVTGCNREDIIKDFEGAHHTVIRSRTVRYDYESAVKEYNNADCVVKFFLETGDV FWFFLQSDIKGRAARHLRTFFEANNFFFGSHCGTMEYCLKQVLIETESVIESFCEERN R" CDS 15495..16112 /codon_start=1 /product="24 kDa protein" /protein_id="QOU11802.1" /translation="MRVIVSPYEAEDILTRSTEMLRNIDSGALDTKECIEAFSTLTRD LHCAKASYQWCVDTGLCQRDCAEKRLIDTVESNLRLAQPLIREKVATHFCKDEPKELV AFITRKYVKLTGVAAREAVKIEMRTLSKTVLNKLSLEMAFYISPRAWKNAEWLDLRYT PLKIYRDLLLDVDTLNALCEEDEIHVVVTNKDEDENHDLELQEDC" BASE COUNT 2632 a 1981 c 2549 g 2737 t ORIGIN 1 ttacatgact tcccttccgt cccttcagac ttgcttcact cagtgcgagt tttcctctct 61 ttttatttgt ttggcttctt tccaaaaaat aaaaacattt ctttctttcc taagttcagt 121 gcgtgaactc gctctctttt ctgaactgtc cacgattgga ttctgctgtg aattcattcg 181 cttaggtgtt ggagaacatc ctttgttttt tgtttccttc cagtgcggac ctttgtccgt 241 gtgtttgggg tgtgtgaatg gtatttttgc cgttctcaac atttcttttc cctttttcga 301 cgttgcttcg ttgttgatgg acgttggtga tgtggtcgct ccgaccaagg taagaatttc 361 caaacgagag aagaagttga ataagcgcgc tttttcaata gcccgtgctg ctgcgcgtat 421 taggcgttcc aaggttggaa ataaggaggt tcgcatctct catgtgcagc ccctccctgc 481 tggttgctta cggttttccc aaaacaaaaa cagatcagaa ctcatcataa taggtcggga 541 cgtaggtgtt gtggcgcgcg taaaaaccgn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnaga ttagagaggt 1141 cgttttgcgc tttcgcgtgg gcggtgatat gcgtttctct aggttcttcg catcaaccca 1201 cggttgcaaa attgttgcca acgtgcgcac caacacttcc gtgtggttga actgcactaa 1261 ggtcaatggt gaaaaatttt cggtggcgat cccttgttcg gtggattatg tagcgatgct 1321 gcgttacgtg agtggcggga aattcccgct tgtcctgatg agcagggaat gttaccctga 1381 tgggctatgt tacatggctc acatgaggta tctgtgtgct ttcttttgcc aacctttcag 1441 agaatcagac tatcctctgg gttcgtggcc atcggtggcg cgattgaagg cgttggtttt 1501 gaagcgcttt ggtgacgagg cgctgaatat aggcgttcgc ggctactatg tctctcgtag 1561 ggcttttcat tgcgactacg attctaaata cgcgagaagc ttgatgaggc ttgtggggca 1621 tgtcggggga gacgaggttg tacattcaac gttggcgtcc acggtcgtgt taaaaccggg 1681 tgaacgcgca cgcgatcgtc cgaaaagcat aagttttgga tcgttttgct gcgagttgcg 1741 ttacgtcgaa tccgtcaatc ctgacgcccc tcgcttgcga agtgagaagg ttctgaggaa 1801 agtggagccg cgcaatgggg ttcgcacgga aagcgctgac gttggttcga acgtcacacg 1861 gaagcgcgac gcccgcatcg atagaaagtt ttcgcatctt ttagcgggaa gtgttaataa 1921 agtgaagaaa cgaatcgcgg ccggggtgtt gcgatatcga gtcggcggtg acatggactt 1981 tcataactcc tttcttaccc aagcgggcta ccacttgcta gtgcggcnnn nnnnnnnnnn 2041 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2101 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2281 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2341 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2401 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2461 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2581 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2761 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2821 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2881 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2941 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3001 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3061 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt gtgtttaccc gggtacgata ttatatactt 3481 agattcaaaa tttgtgagtc gtgttttcga ctacgtagtg tgtaattgtt ccgcggtgaa 3541 ctcaaagact ttcgaatggg tctggagttt cattaagtcc agcaaatcga gagtgattat 3601 tagtgggaag atcattcata aagatgtcaa ccttgatctc aagtacgtcg agagtttcgc 3661 tgccgtgatg cttgcgtcgg gtgtgcgcag caggttggct tcggagtatc tcgcgaagaa 3721 tctcagtcat ttttcgggag attgctcctt tatcgaagcg acctcttttg ttctgcgtga 3781 gaagattaga aatatgaccc ttaacttcaa tgaatgtctt ctgcagttgg tgaaacgcgt 3841 ggcatttgcg actttagacg taagtttctt agatctggat gccactatgg aatcaatcac 3901 agacttcgcc gaatgcaaag tagctgtgga acttgaagag ttgggatgtt tgagagcgaa 3961 tgccgagaat gagaaaattc ggaacctcgc tggcgactca atggcagcga aattggctag 4021 cgagatagtg gtcgacatag acgcgaaacc tgtcgctaaa cacgcagaac acccgaagag 4081 tgaagtgagt gaaaagaagg agcacgcgaa acccggcttg cgtggaggct cgaaagccgg 4141 agttttgaaa gagttcctcg gnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4621 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnat gctttcctgc tccaaattac 4681 taagagcttc tctttggagc ttatcgtccg gaacgtggtg cgcgtgacgc attctttgag 4741 caccacggcg actgatggag tgatgcgcag cgtcttctct caaataatca gtcacctgct 4801 tgtgggaaac actggtaact tagcttatca aatagctttt ttaaccgggg tggtgccctt 4861 gttagtgaag aaatgcgtgg gtttgatttt ttcgatgagc gaggacacat actctggctt 4921 tatcaagcat ggggttagtg aattttcgtt catcactaat atcttaaaat acctgagagg 4981 acagctggta gacgaattga aagcggtggt tcaaggagtt tttgactcga ataaacatct 5041 ctttcgtgat gttactcagg aggcgatccg gtcgaccgtt atgcagatac caaccgccgt 5101 ggtggatggt ttgaaatgtg cggctagtaa agtgtatagc ggaatagtcg gtaaaaagac 5161 gaatgttggg gaannnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5281 nnnnnnnnnn nnnnnnnnnn nnnnnnnncg cattttgatt ggtagaataa agcataggtg 5341 cttctcgaaa atttttgaga gtatctcgtt gaagattcat gagcttagaa cctttctcct 5401 tggaaagaag cgaagcggcg taggggtgta cgaattccta tccgaggacg tagctgctgc 5461 tctatcctcg ataaatgaat gtgacgaaat cgaaaatctg atcggagacg ggtttcgcga 5521 tatggcggat gactctctca cggacatgga atacttcgac ttctcagacg aatttttaac 5581 ctccgttaat ggcttacctt gcgctgggtt gcgcggaggc ggtaggaggg tgggaatgct 5641 cgccattctg aattacgttt ataactctct aagcgtcgtg gctagagcag cttcgaaaaa 5701 ttcgactttc acatctctaa tcattttttc gcgcggattg gttgatagaa tccgcaacat 5761 tttttcaaat aaggaaagtg tcgttgagct tgtgcgcaag tacgttaaaa actttttaaa 5821 aagtcgcatg cgcggtttgg gtctaagaaa cgaacatgta gtgaattcgt tcggggagtt 5881 ggtgccactg ctcttacgaa acaagttgtc tgaaactttc atctatcgtg cggtccccat 5941 gtcgaagtgg tgctgggaag tgtgcttgtc agctgagcgg cgggaaaagt ttttcgcgct 6001 cgtgtgctta gtcactctgg gatttcccta cttcgctcgt cttttgggtg gggtagtgtg 6061 cgataagctc ttgtcttcat tacgacgtgc gtacgaccgt gtgatagttt ttctaaannn 6121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnncggtaa 6541 tcctctattg aggggcgttc ggagattcct tcgcttgatc gcggtgaagc tgaaccttcg 6601 aaggaagaga ggactgagaa cgagaaatgg tggttacccc agccaaaggg ccgtgccggt 6661 tataccatct aatcgcgtga caaatgacgg atgtgagaga ctgtctgaga agatgcaagg 6721 agtcgaagca ctacgatccg aattaaggat tcttgaagaa cttgatgccg cagtggtgga 6781 gaagctcaac aaacgcagga accgtgaagc ggatgatagc gagttctcgc gccctatgca 6841 cgagagcacg catgatgtga cttccttttg ttcaaaagcg aattcggtag gcacggccct 6901 cgaaagggcg gtgctcgtgg aagatgcggt gaaatctgaa aagatctcga ggatggctaa 6961 agatctggtt cgtaagggga ctgtttccga tgaggaaatc accaacactt tatctgatga 7021 tgaagcgatt gaagaagttc caatctccga agagcgcgac gactcaccca aaacggtaag 7081 ggtgagtgaa tatttgaata gattgaactc aagcttcgaa ttcccgaagc cgatcgtggt 7141 ggacgacaat aaggagactg gagggttaac caacgcggta cgcgaattct actatatgca 7201 ggagctcgct ctatttgaaa tccacagcaa actgtgcgct tactacgacc agttgcggat 7261 cgtgaatttc gaacgctcta tggccccatg taatgaggat gctcagttgt acgttcgtaa 7321 aagcggttcc acaatagtgc agggcaaaga tgtgcgttcg aacatcaagg attttcacga 7381 tcacgatttt ctcttcgatg gcaagatctc cgtaaataga cgacggcgat ctggaaacgt 7441 tctgtaccat gataaccttt cttttctggc gagcaacctg tttctggcgg gatacccttt 7501 ttcacggagt tttgttttca ctaactcttc ggtggatatt cttctttatg aagctcctcc 7561 cggtggtggc aagaccacga ccctaatagn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7621 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7741 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7861 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8041 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8101 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8281 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8341 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8401 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8461 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8581 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8761 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8821 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8881 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8941 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9001 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9061 nnnnnnnnnn nnnnnnnacc aaacacagcg ctgctcagaa cattatgttt catcgtaaaa 9121 gtatcaacgc gattttttca cccattttta acgaagtgaa gaaccgtatc atgagctgtc 9181 ttaagcccaa cataaaattc ttcaccgaga tgactaatag ggattttgct tccgttgtga 9241 gcaacatgct cggtgatgac gatgtttacc atataggcga agtcgatttc tcgaagtatg 9301 acaagtctca ggatgctttc gtgaagtcct ttgaagaagt catgtacaaa gaactcgggg 9361 ttgacgagga actcttagcg atttggatgt gtggtgaaag gctttccatt gcgaatacgc 9421 ttgacggtca gctgtctttc acgattgaga accagagaaa atcgggtgcc tcaaacacgt 9481 ggatcggtaa ttctcttgtt acgctgggca tactaagcct ctattatgac gtgaggcatt 9541 ttgaggctct ctacgtctct ggtgacgact ctctgatttt ttcacgcaac aaaatttcga 9601 attacgctga tgatatctgc gctgatatgg gtttcgaaac gaagtttatg tctccgagtg 9661 ttccgtattt ttgttccaaa ttcgtcgtta tgtgcggaca caagaccttt tttgtgcctg 9721 atccgtataa gttattcgtg aaactgggag ctgtaaagga ggatgtctct atggattttc 9781 tctttgaaac tttcacctcc tttaaggatt tgacttcgga ttttaacgat gagcgcgtga 9841 ttcagaaact cgctgagctt gttgctctca aatacgacgt tcagagtggt aataccactc 9901 tagcgttgag cgtgatacat tgtttgcgtt ctaactttct atcgttcagc aaactgtacc 9961 ctcgtgtgaa aggatggcag gttttttaca cctccgttaa gaaagcactt tttaagagcg 10021 ggtgctcact ctacgaaagc tacgtcactc cattcggtca tgcagtgacg gtgtgggatg 10081 atgagtagca cgcgactctt gcgtagtttt gaacggtact gtttccgcga ctgcgggatg 10141 atcacgtgac atacacgatg tgtgtcactg tatagatatt atggaccagg ttctgcagtt 10201 cgagtgtctg tatctgctca accaggcggt ttttgcaata acattcgtct tcattctgct 10261 catcattcgc gtgattaaat ctttccgcag aaacgtacac gaaactccag tatcggccgt 10321 ccgtgggcag gggttctcga ctgttgtgtg atttgcgaaa tggttgtttt tggtttagag 10381 ttcgggacga ctttttcgac gggctgcgtg tataaagatg gtaaggttta ctcattcaaa 10441 caaaacaatt ctgcgtacat nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10621 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10741 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10861 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11041 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11101 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11281 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11341 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11401 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11461 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11581 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11761 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11821 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11881 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11941 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 12001 nnnnnnnnnn nnnnnnnnnn nnnngttgcg gatgtgctaa aagaatttaa gagctacaac 12061 gctagttctc taccaccaga cgaagatgtc gaaccactca tggggaagtc tgttcaaaaa 12121 gtactacggg gaggcagatt ggaggaaata cctctctaag agcattgtag cccacacagc 12181 taacataaaa actttgccgg acgttcagtt gtacggcggt agaactgtga agaagtccga 12241 atttgaatcg gtgactccga ggtcgttcga gcaggaatta ggacttctga tgttaaatga 12301 acgggacgtg ggttggtgta agatgtgcgg gataactgtg gaggaggcaa tgtaccaaat 12361 cacgaaccct gaagcgtatc cgatcacagc ggaaaaatgc gatccagatg tgaaaactga 12421 ggggcagaaa tacacgatgg aagacgtgat gaatttcatg cgtcgttcca acctagatat 12481 aaatgataaa atcttagcgg aacagtgttg gtctctatcc aatnnnnnnn nnnnnnnnnn 12541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 12601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 12661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnngta 12721 ttgcgcttac atcagaactt acttagaaaa taccgatttg tatttcactt ctcccgatag 12781 gataccgtta ctcaccggca ttctctatga tttctgcaag gagtataata tcttttattc 12841 cacatacaaa cgaaacgttg ataatttcag gttcttccta acgaattata tgcccttgat 12901 ttcagacata ttcgttttcc agtgggtaaa accggcaccg gacgtgagat tactattcga 12961 tataagcgca gccgaattga ctttagaagt tccaacgtta agcttagtgg attcgcaggt 13021 ggtgatagga catgtcctga gatttgtcga atcatacact gctgatccgg ctattgacgc 13081 gttggaagag aaattggacg ctataatgaa ggagagtnnn nnnnnnnnnn nnnnnnnnnn 13141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 13201 nnnnnnnnnn nnnnngtata agacgcccaa ttcggtcgga ggtttcgaga ttaatatgaa 13261 aaacgtcgaa gagttttttg ataagatcca acgagaggtg ccaaacgtgt ctctgcggcg 13321 acaattcaac ggagccagag cgcacgaggc attcaaagta tttaaaaagg gaaacatcag 13381 cttcaaaccc atatctcggt taaacatacc gagggagttc tggtatctga atgtggatta 13441 ttttagacat gcgaacagaa gcggactgag cgaagaggag gtgctcattc ttaataatat 13501 aagcgtagat gttcgtaaat tgtgtgcgga aagagcgtgc agcactctgc ctagcgcgaa 13561 gcgctttagc aaaggtcata aaagtagtgt gccatcattg cgtcaagaga aaaattatag 13621 agatccgttg atcacgttaa gaaactcttt acatgagttc cggcacggga gtcgcgatag 13681 gagggtctga ggccatcgag acctcaggtt tcgtgctatc tacgcgaaag gaagccgtcg 13741 ataagttctt caatgaacta aggaacgaaa attattcttc ggtcgacagc agtcggttaa 13801 gcgaccaaga ggtgaaagaa gttctggaga aaagtaaaga gagctttaaa agcgaattag 13861 cgtccaccga cgaacacttc gtttatcaca tcatcttctt tctgattcga tgcgccatta 13921 tatccacgag cgataaggta aaatacgtag ggagccataa gtacgtagtc gaaggaaaga 13981 cgtacacagt tcaagacgtt tgggttttta acatgattaa ggggctgacc aagcagtaca 14041 aaagggtgaa tggtttgcgt gctttctgtt gtgcctgtga agatttgtat ctgacagttg 14101 ctcccgcgat gtctgaacgc ttcaaaacca aggctatcgg tatgaagggc ctacccgtcg 14161 gaaaggagta tttaggtgct gactttctct ctggaacgag tagattgatg agcgatcacg 14221 atagagctgt atccatagtc gcggccaaga acgctgtcga tcgtagcgca tttaccggtg 14281 gagagaggaa gatagttagt ttgtatgact taggaaggaa ctaagcacgt tgtgctatag 14341 tgcgcgtcat aatattaagt actagtgcat attaacaagc agtagtgttt aaagtgtagt 14401 gataagaaac aatggagttg atgtccgatg ataacttgag cggtctcgtc ataaccgacg 14461 cttctagttt gaatggtgcc gataagaaac tgctgtttgc ggaggtcata aaaatgcttg 14521 tgcagaaggg ggcgcccagc gaaggtattg aaatagtctt tgggctactg ctctacgctc 14581 tcgcagcgag aaccacatcg cccaaagttc agagggctga ttctgatata atctttcaaa 14641 acacttacgg tgacaagact gttgtcgtga cagaaggtga tctcaagaaa gtgcttgaag 14701 ggtgcgcacc tcttaataga ttcactaaca agctgcgaac tttcggccgc acgtttacgg 14761 aggcgtatat tgatttctgc gcggcttaca agcataagat gcctcagctc aacgcggccg 14821 caaaattggg gataccagca gaagattcgt acctagctgc ggacttttta ggtgcttgcc 14881 cgaaactctc tgaattacaa caaagtagaa aaatgtttgc aagtatgtac gctttgaaga 14941 ctgagggcgg agtagaaaat acgcccgtta gtaatttgcg ccaattaggt aggagagaag 15001 ttatgtgatg gaaatttgcg ctcagaatcc tgaggcacta gtgctattac gcacaaatca 15061 aaacacaaca ttactagtcg tcaagtctga tgatgaagtt aatctgccga aattgttaat 15121 atgcgggtat ttacgcgtgt cgcatcgtgg ggatgtgact ggttgtaatc gcgaagacat 15181 aataaaggat tttgaaggtg cacatcatac cgtcatccgc tcgagaacgg tacggtatga 15241 ttacgagtcc gcagttaaag agtacaataa cgctgattgc gtggtgaaat tctttttaga 15301 aacaggagac gttttttggt tttttctcca aagtgacatc aaaggaagag cggcgcgaca 15361 cttgcgcacc ttcttcgaag ctaacaattt cttctttgga tcgcattgcg gtaccatgga 15421 gtattgtttg aagcaggtac tgatagaaac tgagtctgta atcgaatctt tttgtgaaga 15481 aagaaatcgt taagatgagg gtgatagtat ctccttatga agctgaagac attctaacaa 15541 gatcaactga aatgttgcga aacatagaca gtggagcgtt ggatacgaaa gagtgcattg 15601 aagcgttctc gacgctaacg cgagatttgc actgcgcaaa agcatcgtac caatggtgcg 15661 ttgacacagg gttgtgccaa cgtgattgcg ccgaaaaacg cttgatcgac accgttgaat 15721 caaatctgag actcgctcaa cctctcatac gcgagaaggt ggcgactcat ttttgcaaag 15781 atgaacccaa agaactagtg gcgttcatca cgcggaaata cgttaagctc acaggtgtgg 15841 cggcgcggga ggctgtaaaa atagaaatgc gcactctatc taagacagtt ttaaataaac 15901 tatctttaga aatggccttc tatatatcac ctcgagcgtg gaaaaacgca gaatggttag 15961 atctcaggta tacgcctcta aaaatataca gagatctttt actagacgtg gacacactca 16021 acgccttatg cgaggaggat gaaattcacg tcgtcgtgac caataaagat gaagacgaga 16081 atcatgatct cgagcttcaa gaagactgtt aaagtctaaa attctagaat cgcaatatgt 16141 ttgcgagtag taaataaaat cgaacgtggg tggatctacc tgacgtatca actttagctg 16201 ttactgggta attaagctaa caagtgttag cgtaatgtgt atgttgatga agagaaaata 16261 ccgtttctag at //