LOCUS MF056836 16513 bp DNA circular HUM 12-AUG-2017 DEFINITION Homo sapiens isolate 2388 mitochondrion, partial genome. ACCESSION MF056836 VERSION MF056836.1 KEYWORDS . SOURCE mitochondrion Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 16513) AUTHORS Pierron,D., Heiske,M., Razafindrazaka,H., Rakoto,I., Rabetokotany,N., Ravololomanga,B., Rakotozafy,L.M., Rakotomalala,M.M., Razafiarivony,M., Rasoarifetra,B., Raharijesy,M.A., Razafindralambo,L., Ramilisonina, Fanony,F., Lejamble,S., Thomas,O., Mohamed Abdallah,A., Rocher,C., Arachiche,A., Tonaso,L., Pereda-Loth,V., Schiavinato,S., Brucato,N., Ricaut,F.X., Kusuma,P., Sudoyo,H., Ni,S., Boland,A., Deleuze,J.F., Beaujard,P., Grange,P., Adelaar,S., Stoneking,M., Rakotoarisoa,J.A., Radimilahy,C. and Letellier,T. TITLE Genomic landscape of human diversity across Madagascar JOURNAL Proc. Natl. Acad. Sci. U.S.A. (2017) In press PUBMED 28716916 REMARK Publication Status: Available-Online prior to print REFERENCE 2 (bases 1 to 16513) AUTHORS Pierron,D., Heiske,M., Razafindrazaka,H., Rakoto,I., Ravololomanga,B., Rakotozafy,L., Rakotomalala,M., Razafiarivony,M., Rasoarifetra,B., Raharijesy,M., Razafindralambo,L., Ramilisonina,R., Fanony,F., Lejamble,S., Thomas,O., Abdallah,A., Rocher,C., Arachiche,A., Tonaso,L., Pereda-loth,V., Schiavinato,S., Brucato,N., Ricaut,F.-X., Kusuma,P., Sudoyo,H., Ni,S., Boland,A., Deleuze,J.-F., Beaujard,P., Grange,P., Adelaar,S., Stoneking,M., Rakotoarisoa,J.-A., Radimilahy,C. and Letellier,T. CONSRTM Mage TITLE Direct Submission JOURNAL Submitted (04-MAY-2017) Equipe de medecine evolutive Laboratoire d'Anthropologie Moleculaire et Imagerie de Synthese, CNRS, Universite de Toulouse, allee jule guesdes, Toulouse 31073, France COMMENT ##Assembly-Data-START## Assembly Method :: Burrows-Wheeler Aligner v. 2010 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..16513 /organism="Homo sapiens" /organelle="mitochondrion" /mol_type="genomic DNA" /isolate="2388" /db_xref="taxon:9606" D-loop complement(<1..563) tRNA 563..633 /product="tRNA-Phe" rRNA 634..1587 /product="12S ribosomal RNA" gap 936..1038 /estimated_length=103 tRNA 1588..1656 /product="tRNA-Val" rRNA 1657..3214 /product="16S ribosomal RNA" tRNA 3215..3289 /product="tRNA-Leu" /note="codons recognized: UUR" gene 3292..4247 /gene="ND1" CDS 3292..4247 /gene="ND1" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:4246..4247,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="ASS07782.1" /translation="MPMANLLLLIVPILIAMAFLMLTERKILXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXALTIALLLWTPLPMPNPLVNLNLGL LFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTIXXXXXXXXXXXXTXLMSGSF NLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAG PFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTXLXXXXXXXXXTA YPRFRYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT" gap 3375..3520 /estimated_length=146 tRNA 4248..4316 /product="tRNA-Ile" tRNA complement(4314..4385) /product="tRNA-Gln" tRNA 4387..4454 /product="tRNA-Met" gene 4455..5496 /gene="ND2" CDS 4455..5496 /gene="ND2" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:5496,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="ASS07783.1" /translation="MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVL TKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAM AMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLL LNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSL IIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTT LLLPISPFMLMIL" tRNA 5497..5564 /product="tRNA-Trp" tRNA complement(5572..5640) /product="tRNA-Ala" tRNA complement(5642..5714) /product="tRNA-Asn" tRNA complement(5746..5811) /product="tRNA-Cys" tRNA complement(<5811..5856) /product="tRNA-Tyr" gap 6054..6351 /estimated_length=298 gene <6364..7430 /gene="COX1" CDS <6364..7430 /gene="COX1" /codon_start=3 /transl_table=2 /product="cytochrome c oxidase subunit I" /protein_id="ASS07784.1" /translation="GAINFITTIINMKPPAMTQYQTPLFVWSXLITAVLLLLXXXXXX XXXXXXXXXRXXNXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPGFGMISHIVTYY SGKKEPFGYMGMVWAMMSIGFLGFIVWAXHXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXLGXIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHF HYVLSMGAVFXXXXXXXXXXXXXXGYTXXQXXXXXHFTIMFIGVNLTFFPQHFLGLSG MPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLE WLYGCPPPYHTFEEPVYMKS" gap 6763..6910 /estimated_length=148 tRNA complement(7430..7501) /product="tRNA-Ser" /note="codons recognized: UCN" tRNA 7503..7570 /product="tRNA-Asp" gene 7571..8254 /gene="COX2" CDS 7571..8254 /gene="COX2" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit II" /protein_id="ASS07785.1" /translation="MXXAAQXGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFL TLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGH QWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVL HSWAVPTLGLKXXAIPGRLNXXXXXXXRPGVYYGQCSEICGANHSFMPIVLELIPLKI FEMGPVFTL" tRNA 8280..8349 /product="tRNA-Lys" gene 8351..>8557 /gene="ATP8" CDS 8351..>8557 /gene="ATP8" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="ASS07786.1" /translation="MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLPPSPKPMKM KNYNKPWEPKWTKIXXXXXXXXXXX" gene 8512..9192 /gene="ATP6" CDS 8512..9192 /gene="ATP6" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="ASS07787.1" /translation="MNENXXXXXXXXXXXXXXXXXXXXXXXPLLXXXSKYLINNRLIT TQQWLIKLTSKQMMAMHNTKGRTWSLMLVSLIIFIATTXXXGLLPHSFTPTTXLXXXX XXXXXXXXXXXXXXXXXXXXXXXXXFXPQGTPTPLIPMLVIIETISLLIQPMALAVRL SANITAGHLLMHLIGSTTLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLV SLYLHDNT" gene 9192..>9965 /gene="COX3" CDS 9192..>9965 /gene="COX3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit III" /protein_id="ASS07788.1" /translation="MTHQSHAYXXXXXXPWPLTXALSALLMTSGLAMWFHFHSMTLLM LGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXVPXXNXSVLLASGVSITWAXHSLMENXRNQXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTGFHGLHVIIGSTFLTIC FIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYW" gap 9668..9781 /estimated_length=114 tRNA 9976..10043 /product="tRNA-Gly" gene 10044..10389 /gene="ND3" CDS 10044..10389 /gene="ND3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:10389,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="ASS07789.1" /translation="MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPM SPAXXXXSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSL AYEWLQKGLDWAE" tRNA 10390..10454 /product="tRNA-Arg" gene 10455..10751 /gene="ND4L" CDS 10455..10751 /gene="ND4L" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="ASS07790.1" /translation="MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMA TLMTLNTHSLLANIVPIAMLVFAACEAAVGLAXXXXXXXXXXXXXXXXXXXXXC" gene 10745..12122 /gene="ND4" CDS 10745..12122 /gene="ND4" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:12122,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="ASS07791.1" /translation="MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQ INNNLFSCSPTXXXXXXXXPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISL QISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPL LIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPK AHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSIC LRQTXLKSLIAXSXXXXXXXXVTAILIQTPWSFTGAVXXXXXXXXTSSLLFCLANSNY ERTXSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNXX LLLTGLNMLVTXXXXXXXFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLN PDIITGFSS" tRNA 12123..12191 /product="tRNA-His" tRNA 12192..12250 /product="tRNA-Ser" /note="codons recognized: AGY" tRNA 12251..12321 /product="tRNA-Leu" /note="codons recognized: CUN" gene 12322..14133 /gene="ND5" CDS 12322..14133 /gene="ND5" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="ASS07792.1" /translation="MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTF IISLFPTTMFMCLDQEVIISNWHWATTQTTXXXXSFKLDYFSMMFIPVALFVTWSIME FSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLXXXXXX XADANTXAIQAXLYXRIGDIGFILALAWFILXSXXWXXXXXXXXXXXXXXXXXXXXXX XXXXXXXQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLTENSPLIQTL TLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAXLHXXXXXX XKAMXXXXXXXXXXXXXXXXXXXXXXXXXXXXPLXSXSLXIGSLALAGMPFLTGFYSK DHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTL LNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTAXXXTFLGLLTALDLNYLT SKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTI SQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT" gene complement(14134..14658) /gene="ND6" CDS complement(14134..14658) /gene="ND6" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="ASS07793.1" /translation="MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIIL NFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGL VLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL FVGVYIVIEIARGN" tRNA complement(14659..14727) /product="tRNA-Glu" gene 14732..15872 /gene="CYTB" CDS 14732..15872 /gene="CYTB" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15872,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="ASS07794.1" /translation="MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQ ITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGL YYGSFLYSETWNIGIILLLATMATAFMGYXXPXXXXXXXXXXXXTNXXXXXXXXXXXX XXXXXXXYSVDSPTLTRFFXFXFILPFIITALAALHLLFLHETGSNNPLGITSHSDKI TFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLF AYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLI LTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA" tRNA 15873..15938 /product="tRNA-Thr" tRNA complement(15940..16008) /product="tRNA-Pro" D-loop complement(16013..>16513) BASE COUNT 4402 a 4411 c 1807 g 3446 t ORIGIN 1 tcnnnnnnnn nnnnncncnc gggngcnctc catgcanntg gtatttncgn ctggggggtg 61 tgcacgcnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnncc ctatgtcgca gnanctgnct 121 ttgattcctg cctcatccat tatttatcgc acctacgttc aatattacag gcgaacatac 181 ttactaaagt gtgttaatta attaatgctt gtaggacata gtaataacaa ttgaatgtct 241 gcacagccgc tttccacaca gacatcataa caaaaaattt ccaccaaacc ccnnnncccc 301 cncntctggc cacagcactt aaacacatct ctgccaaacc ccaaaaacaa agaaccctaa 361 caccagccta accagattnc aantnttatc nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnntnnn nnnnnnnnca tcaatacaat 481 ccccgcccat cctacccagc acacacacac cgctgctaac cccatacccc gaaccaacca 541 aaccccaaag acacccccca cagtttatgt agcttacctc ctcaaagcaa tacactgaaa 601 atgtttagac ggnntcanan cnccccatan ncaantaggt nnggtcctag cctttctnnn 661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc 721 gccacgatca nnnnnnnnnn nnnnnnnnnn nnnnnnnatg cagctcaaaa cgcttagcct 781 agccacaccc ccacgggaaa cagcagtgat taacctttag caataaacga aagtttaact 841 aagctatact aaccccaggg ttggtcaatt tcgtgccagc caccgcggtc acacgattaa 901 cccaannnna nnnnnnncnn ngnnaagngn gntttnnnnn nnnnnnnnnn nnnnnnnnnn 961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1021 nnnnnnnnnn nnnnnnnnaa tagctaagac ccaaactggg attagatacc ccactatgct 1081 tagccctaaa cctcaacagt taaatcaaca aaactgctcg ccagaacact acgannnnnn 1141 nnnnnnnnnn nnnnggacct ggcggtgctt catatccctc tagaggagcc tgttctgtaa 1201 tcgataaacc ccgatcaacc tcaccacctc ttgctcagcc tatataccgc catcttcagc 1261 aaaccctgat gaaggctaca aagtaannnn nannncccnn gnnannacgt taggtcaagg 1321 tgtagcccat gaggtggcaa gaaatgggct acattttcta ccccagnaan ctacganagc 1381 ccttatgaaa cttaagggtc ganggtggnt ttngcagtaa actgagagta gagngcttng 1441 ttnnncnggn ccntgnnncn cgtnnncncc gnnnntcann ctcctcaagt atacttcaaa 1501 ggacatttaa ctaaancccc tacgcattta tanagaggnn acaagnnnnn nnnnnntaag 1561 ngnactggan ngnncacnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1621 cacttaggag atttcaactt aacttgaccg ctctgagcta aacctagccc caaacccact 1681 ccaccttact accagacaac cttagccaaa ccatttaccc aaataaagta taggcgatag 1741 aaattgaaac ctggcgcaat agatatagta ccgcaaggga aagatgaaaa attataacca 1801 agcataatat agcaaggact aacccctata ccttctgcat aatgaattaa ctagaaataa 1861 ctttgcaagg agagccaaag ctaagacccc cgaaaccaga cgagctacct aagaacagct 1921 aaaagagcac acccgtctat gtagcaaaat agtgggaaga tttataggta gaggcgacaa 1981 acctaccgag cctggtgata gctggttgtc caagatagaa tcttagttca actttaaatt 2041 tgcccacaga accctctaaa tccccttgta aatttaactg ttagtccaaa gaggaacagc 2101 tctttggaca ctaggaaaaa accttgtaga gagagtaaaa aatttaacac ccatagtagg 2161 cctaaaagca gccaccaatt aagaaagcgt tcaagctcaa cacccactac ctaaaaaatc 2221 ccaaacatat aactgaactc ctcacaccca attggaccaa tctatcaccc tatagaagaa 2281 ctaatgttag tataagtaac atgaaaacat tctcctccgc ataagcctgc gtcagattaa 2341 aacactgaac tgacaattaa cagcccaata tctacaatca accaacaagt cattattacc 2401 ctcactgtca acccaacaca ggcatgctca taaggaaagg ttaaaaaaag taaaaggaac 2461 tcggcaaatc ttaccccgcc tgtttaccaa aaacatcacc tctagcatca ccagtattag 2521 aggcaccgcc tgcccagtga cacatgttta acggccgcgg taccctaacc gtgcaaaggn 2581 agcnnaatcn cttgntnctn aaatagggac ctgtatgaat ggctccacnn nngttcagct 2641 gtctcttact tttaaccagt gaaattgacc tgcccgtgaa gaggcgggca tgacacagca 2701 agacgagaag accctatgga gctttaattt attaatgcaa acagtaccta acaaacccac 2761 aggncctaaa ctaccaaacc tgcattaaaa atttcggttg gggcgacctc ggagcagaac 2821 ccaacctccg agcagtacat gctaagactt caccagtcaa agcgaactac tatactcaat 2881 tgatccaata acttgaccaa cggaacaagt taccctaggg ataacagcgc aatcctattc 2941 tagagtccat atcaacaann gggtttacga cctcgatgtt ggatcaggac atcccgatgg 3001 tgcagccgct attaaaggtt cgtttgttca angantaann nncnacgnga tctgagttca 3061 gaccggagta atccaggtcg gtttctatct acttcaaatt cctccctgta cgaaaggaca 3121 agagaaataa ggcctacttc acaannnnnn nnnnnnnnna aatgatatca tctcaactta 3181 gtattatacc cacacccacc caagaacagg gtttgttaag atggcagagc ccggtaatcg 3241 cataaaactt aaaactttac agtcagaggt tcaattcctc ttcttaacaa catacccatg 3301 gccaacctcc tactcctcat tgtacccatt ctaatcgcaa tggcattcct aatgcttacc 3361 gaacgaaaaa ttctnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn tagctctcac catcgctctt 3541 ctactatgaa cccccctccc catacccaac cccctggtca acctcaacct aggcctccta 3601 tttattctag ccacctctag cctagccgtt tactcaatcc tctgatcagg gtgagcatca 3661 aactcaaact acgccctgat cggcgcactg cgagcagtag cncaaacaat cnnnnnnnnn 3721 nnnnnnnnnn nnnnnnnnnn nnnnnnaaca nnactaataa gtggctcctt taacctctcc 3781 acccttatca caacacaaga acacctctga ttactcctgc catcatgacc cttggccata 3841 atatgattta tctccacact agcagagacc aaccgaaccc ccttcgacct tgccgaaggg 3901 gaatccgaac tagtctcagg cttcaacatc gaatacgccg caggcccctt cgccctattc 3961 ttcatagccg aatacacaaa cattattata ataaacaccc tcaccactac aatcttccta 4021 ggaacaacat atgacgcact ctcccctgaa ctctacacaa catattttgt caccaagacc 4081 cnactnnnan nnnnccngnt nnnnnnnnnn nnaacagcat acccccgatt ccgctacgac 4141 caactcatac acctcctatg aaaaaacttc ctaccactca ccctagcatt acttatatga 4201 tatgtctcca tacccattac aatctccagc attccccctc aaacctaaga aatatgtctg 4261 ataaaagagt tactttgata gagtaaataa taggagccta aaccccctta tttctaggac 4321 tatgagaatc gaacccatcc ctgagaatcc aaaattctcc gtgccaccta tcacacccca 4381 tcctaaagta aggtcagcta aataagctat cgggcccata ccccgaaaat gttggttata 4441 cccttcccgt actaattaat cccctggccc aacccgtcat ctactctacc atctttgcag 4501 gcacactcat cacagcgcta agctcgcact gattttttac ctgagtaggc ctagaaataa 4561 acatgctagc ttttattcca gttctaacca aaaaaataaa ccctcgttcc acagaagctg 4621 ccatcaagta tttcctcacg caagcaaccg catccataat ccttctaata gctatcctct 4681 tcaacaatat actctccgga caatgaacca taaccaatac taccaatcaa tactcatcat 4741 taataatcat aatggctata gcaataaaac taggaatagc cccctttcac ttctgagtcc 4801 cagaggttac ccaaggcacc cctctgacat ccggcctgct tcttctcaca tgacaaaaac 4861 tagcccccat ctcaatcata taccaaatct ctccctcact aaacgtaagc cttctcctca 4921 ctctctcaat cttatccatc atagcaggca gttgaggtgg attaaaccaa acccagctac 4981 gcaaaatctt agcatactcc tcaattaccc acataggatg aataatagca gttctaccgt 5041 acaaccctaa cataaccatt cttaatttaa ctatttatat tatcctaact actaccgcat 5101 tcctactact caacttaaac tccagcacca cgaccctact actatctcgc acctgaaaca 5161 agctaacatg actaacaccc ttaattccat ccaccctcct ctccctagga ggcctgcccc 5221 cgctaaccgg ctttttgccc aaatgggcca ttatcgaaga attcacaaaa aacaatagcc 5281 tcatcatccc caccatcata gccaccatca ccctccttaa cctctacttc tacctacgcc 5341 taatctactc cacctcaatc acactactcc ccatatctaa caacgtaaaa ataaaatgac 5401 agtttgaaca tacaaaaccc accccattcc tccccacact catcgccctt accacgctac 5461 tcctacctat ctcccctttt atactaataa tcttatagaa atttaggtta aatacagacc 5521 aagagccttc aaagccctca gtaagttgca atacttaatt tctgtaacag ctaaggactg 5581 caaaacccca ctctgcatca actgaacgca aatcagccac tttaattaag ctaagccctt 5641 actagaccaa tgggacttaa acccacaaac acttagttaa cagctaagca ccctaatcaa 5701 ctggcttcaa tctacttctc ccgccgnngg gaaanaaggc gggngnagcc ncggcaggtt 5761 tgaagctgct tcttcgaatt tgcaattcaa tatgaaaatc acctcggagc tggtaaaaag 5821 aggcctaacc cctgtcttta gatttacagt ccaatgnnnn nnnnnnnnnn nnnnnnnnnn 5881 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5941 nnnnnnnnnn nnnnngcgca tgagctggag tcctaggcac agctctaagc ctccttattc 6001 gagccgagct gggccagcca ggcaaccttc taggtaacga ccacatctac ancnnnnnnn 6061 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ntcncnncna 6361 ncntaggggc catcaatttc atcacaacaa ttatcaatat aaaaccccct gccataaccc 6421 aataccaaac gcccctcttc gtctgatccg ncctaatcac agcagtccta cttctcctnn 6481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc agnccgcanc cncaacnccn 6541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnctgntnnn 6601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn taccaggctt cggaataatc tcccatattg 6661 taacttacta ctccggaaaa aaagaaccat ttggatacat aggtatggtc tgagctatga 6721 tatcaattgg cttcctaggg tttatcgtgt gagcacncca tannnnnnnn nnnnnnnnnn 6781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6901 nnnnnnnnnn cctaggantc atctttcttt tcaccgtagg tggcctgact ggcattgtat 6961 tagcaaactc atcactagac atcgtactac acgacacgta ctacgttgta gctcacttcc 7021 actatgtcct atcaatagga gctgtatttn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7081 nnnnnnnnnc aggctacacc ntanaccaan nnnnnnnnna antccatttc actatcatat 7141 tcatcggcgt aaatctaact ttcttcccac aacactttct cggcctgtcc ggaatgcccc 7201 gacgttactc ggactacccc gatgcataca ccacatgaaa catcctatca tctgtaggct 7261 cattcatttc tctaacagca gtaatattaa taattttcat gatttgagaa gccttcgctt 7321 cgaagcgaaa agtcctaata gtagaagaac cctccataaa cctggagtga ctatatggat 7381 gccccccacc ctaccacaca ttcgaagaac ccgtatacat aaaatctaga caaaaaagga 7441 aggaatcgaa ccccccaaag ctggtttcaa gccaacccca tggcctccat gactttttca 7501 aaaaggtatt agaaaancca tnnnnnnnnn nnntcaannn nnnnnnnnnn nnnnnnnnnn 7561 nnntatctna atgncncntg cagcncaagn aggtctacaa gacgctactt cccctatcat 7621 agaagagctt atcacctttc atgatcacgc cctcataatc attttcctta tctgcttcct 7681 agtcctgtat gcccttttcc taacactcac aacaaaacta actaatacta acatctcaga 7741 cgctcaggaa atagaaaccg tctgaactat cctgcccgcc atcatcctag tcctcatcgc 7801 cctcccatcc ctacgcatcc tttacataac agacgaggtc aacgatccct cccttaccat 7861 caaatcaatt ggccaccaat ggtactgaac ctacgagtac accgactacg gcggactaat 7921 cttcaactcc tacatacttc ccccattatt cctagaacca ggcgacctgc gactccttga 7981 cgttgacaat cgagtagtac tcccgattga agcccccatt cgtataataa ttacatcaca 8041 agacgtcttg cactcatgag ctgtccccac attaggctta aaannngnng caattcccgg 8101 ncgtctaaac naanncnnnn nnnnnnnnnc acgaccgggg gtatactacg gtcaatgctc 8161 tgaaatctgt ggagcaaacc acagtttcat gcccatcgtc ctagaattaa ttcccctaaa 8221 aatctttgaa atagggcccg tatttaccct atagcacccc ctctaccccc tctagagccc 8281 actgtaaagc taacttagca ttaacctttt aagttaaaga ttaagagaac caacacctct 8341 ttacagtgaa atgccccaac taaatactac cgtatggccc accataatta cccccatact 8401 ccttacacta ttcctcatca cccaactaaa aatattaaac acaaactacc acctacctcc 8461 ctcaccaaag cccataaaaa taaaaaatta taacaaaccc tgagaaccaa aatgaacgaa 8521 aatcnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8581 nnnnnnnnnn nncctctntt gntcnccncc tccaaatatc tcatcaacaa ccggctaatc 8641 accacccaac aatgactaat caaactaacc tcaaaacaaa tgatagccat acacaacact 8701 aaaggacgaa cctgatctct tatactagta tccttaatca tttttattgc cacaactanc 8761 cnccncggnc tcctgcctca ctcatttaca ccaaccaccc ntctnnnnnn nnnnnnnnnn 8821 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8881 nnnnnnnnnn acttcttncc acaaggcaca cctacacccc ttatccccat actagttatt 8941 atcgaaacca tcagcctact cattcaacca atagccctgg ccgtacgcct atccgctaac 9001 attactgcag gccacctact catgcaccta attggaagca ccaccctagc aatatcaacc 9061 attaaccttc cctctacact tatcatcttc acaattctaa ttctactgac tatcctagaa 9121 atcgctgtcg ccttaatcca agcctacgtt ttcacacttc tagtaagcct ctacctgcac 9181 gacaacacat aatgacccac caatcacatg cctatcannt ngnnnaancc ngcccatgac 9241 ccctaacann ggccctctca gccctcctaa tgacctccgg cctagccatg tgatttcact 9301 tccactccat aacgctcctc atactaggcc tactaaccaa cacactaacc atataccaat 9361 gatggcgcga tgtaacacga gaaagcacat accaaggcca ccacacacca cctgtccaaa 9421 aaggccttcg atacgggata atcctattta tcacctcaga agtttttttc ttcgcannnn 9481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nagnagtccc acnccnaaac anatccgtat 9601 tactcgcatc aggagtatca atcacctgag ctnaccatag tctaatagaa aacanccgaa 9661 accaaatnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9781 ntnntgnnnc cacnggcttc cacggacttc acgtcattat tggctcaact ttcctcacta 9841 tctgcttcat ccgccaacta atatttcact ttacatccaa acatcacttt ggcttcgaag 9901 ccgccgcctg atactggcat tttgtagatg tggtttgact atttctgtat gtctccatct 9961 attgangang nnnnnnnnnn nnnnnnnnan atngnaccgt taacttccaa ttaactagtt 10021 ttgacaacat tcaaaaaaga gtaataaact tcgccttaat tttaataatc aacaccctcc 10081 tagccttact actaataatt attacatttt gactaccaca actcaacggc tacatagaaa 10141 aatccacccc ttacgagtgc ggcttcgacc ctatatcccc cgcnnnnnnn nnnnnctcca 10201 taaaattctt cttagtagct attaccttct tattatttga tctagaaatt gccctccttt 10261 tacccctacc atgagcccta caaacaacta acctgccact aatagttatg tcatccctct 10321 tattaatcat catcctagcc ctaagtctgg cctatgagtg actacaaaaa ggattagact 10381 gagccgaatt ggtatatagt ttaaacaaaa cgaatgattt cgactcatta aattatgata 10441 atcatattta ccaaatgccc ctcatttaca taaatattat actagcattt accatctcac 10501 ttctaggaat actagtatat cgctcacacc tcatatcctc cctactatgc ctagaaggaa 10561 taatactatc gctgttcatt atagctactc tcataaccct caacacccac tccctcttag 10621 ccaatattgt gcctattgcc atactagtct ttgccgcctg cgaagcagcg gtgggcctag 10681 ccnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10741 nnnaatgcta aaactaatcg tcccaacaat tatattacta ccactgacat gactttccaa 10801 aaagcacata atttgaatca acacaaccac ccacagccta attattagca tcatccccct 10861 actatttttt aaccaaatca acaacaacct atttagctgt tccccaaccn nnnnnnnnnn 10921 nnnnnnnnca ncccccctcc taatactaac tacctgactc ctacccctca caatcatggc 10981 aagccaacgc cacttatcca gtgaaccact atcacgaaaa aaactctacc tctctatact 11041 aatctcccta caaatctcct taattataac attcacagcc acagaactaa tcatatttta 11101 tatcttcttc gaaaccacac ttatccccac cttggctatc atcacccgat gaggcaacca 11161 gccagaacgc ctgaacgcag gcacatactt cctattctac accctagtag gctcccttcc 11221 cctactcatc gcactaattt acactcacaa caccctaggc tcactaaaca ttctactact 11281 cactctcact gcccaagaac tatcaaactc ctgagccaac aacttaatat gactagctta 11341 cacaatagct tttatagtaa agatacctct ttacggactc cacttatgac tccctaaagc 11401 ccatgtcgaa gcccccatcg ctgggtcaat agtacttgcc gcagtactct taaaactagg 11461 cggctatggt ataatacgcc tcacactcat tctcaacccc ctgacaaaac acatagccta 11521 ccccttcctt gtactatccc tatgaggcat aattataaca agctccatct gcctacgaca 11581 aacagnccta aaatcgctca ttgcatnctc tncaatnnnn nnnnnnnnnn nnnnngtaac 11641 agccattctc atccaaaccc cctgaagctt caccggcgca gtcnnnnnnn nnnnnnnnnn 11701 nnnnnntaca tcctcattac tattctgcct agcaaactca aactacgaac gcactcncag 11761 tcgcatcata atcctctctc aaggacttca aactctactc ccactaatag ctttttgatg 11821 acttctagca agcctcgcta acctcgcctt accccccact attaacctac tgggagaact 11881 ctctgtgcta gtaaccacgt tctcctgatc aaatancnct ctcctnctta caggactcaa 11941 catactagtc acagnnnnan ncnnnnncna catntttacc acaacacaat ggggctcact 12001 cacccaccac attaacaaca taaaaccctc attcacacga gaaaacaccc tcatgttcat 12061 acacctatcc cccattctcc tcctatccct caaccccgac atcattaccg ggttttcctc 12121 ttgtaaatat agtttaacca aaacatcaga ttgtgaatct gacaacagag gcttacgacc 12181 ccttatttac cgagaaagct cacaagaact gctaactcat gcccccatgt ctaacaacat 12241 ggctttctca acttttaaag gataacagct atccattggt cttaggcccc aaaaattttg 12301 gtgcaactcc aaataaaagt aataaccatg cacactacta taaccaccct aaccctgact 12361 tccctaattc cccccatcct taccaccctc gttaacccta acaaaaaaaa ctcatacccc 12421 cattatgtaa aatccattgt cgcatccacc tttattatca gtctcttccc cacaacaata 12481 ttcatgtgcc tagaccaaga agttattatc tcgaactgac actgagccac aacccaaaca 12541 acnnnnnnnn nnnnaagctt caaactagac tacttctcca taatattcat ccctgtagca 12601 ttgttcgtta catggtccat catagaattc tcactgtgat atataaactc agacccaaac 12661 attaatcagt tcttcaaata tctactcatt ttcctaatta ccatactaat cttagttacc 12721 gctaacaacc tattccaact gttcatcggc tgagagggcg taggaattat atccttcttg 12781 ctcatnnnnn nnnnnnnnnn nnnagcagat gccaacacan cagccattca agcaanccta 12841 tacanccgta tcggcgatat cggtttcatc ctcgccttag catgatttat cctacnctcc 12901 ancncatgag ancnacnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 12961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnngnccaat taggtctcca cccctgactc 13021 ccctcagcca tagaaggccc caccccagtc tcagccctac tccactcaag cactatagtt 13081 gtagcaggaa tcttcttact catccgcttc caccccctaa cagaaaatag cccactaatc 13141 caaacnctaa cactatgctt aggcgctatc accactctgt tcgcagcagt ctgcgccctt 13201 acacaaaatg acatcaaaaa aatcgtagcc ttctccactt caagtcaact aggactcata 13261 atagttacaa tcggcatcaa ccaaccacac ctagcantcc tgcacannnn nnnnnnnnnn 13321 nnnntcaaag ccatannnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 13381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnncnntac cnctnncntc nncctccctc 13441 ancattggca gcctagcatt agcaggaata cctttcctca caggtttcta ctccaaagac 13501 cacatcatcg aaaccgcaaa catatcgtac acaaacgcct gagccctatc tattactctc 13561 atcgctacct ccctgacaag cgcctatagc actcgaataa ttcttctcac cctaacaggt 13621 caacctcgct tccccaccct tactaacatt aacgaaaata accccaccct actaaacccc 13681 attaaacgcc tggcagccgg aagcctattc gcaggatttc tcattactaa caacatttcc 13741 cccgcatccc ccttccaaac aacaatcccc ctctacctaa aactcacagc ccnnnctgnc 13801 actttcctag gacttctaac agccctagac ctcaactacc taaccagcaa acttaaaata 13861 aaatccccac tatgcacatt ttatttctcc aacatactcg gattctaccc tagcatcaca 13921 caccgcacaa tcccctatct aggccttctt acgagccaaa acctgcccct actccttcta 13981 gacctaacct gactagagaa gctattacct aaaacaattt cacagcacca aatctccacc 14041 tccatcatca cctcaaccca aaaaggcata attaaacttt acttcctctc tttcttcttc 14101 ccactcatcc taaccctact cctaatcaca taacctattc ccccgagcaa tctcaattac 14161 aatatataca ccaacaaaca atgttcaacc agtaactact actaatcaac gcccataatc 14221 atacaaagcc cccgcaccaa taggatcctc ccgaatcaac cctgacccct ctccttcata 14281 aattattcag cttcctacac tattaaagtt taccacaacc accaccccat catactcttt 14341 cacccacagc accaatccta cctccatcgc taaccccact aaaacactca ccaagacctc 14401 aacccctgac ccccatgcct caggatactc ctcaatagcc atcgctgtag tatatccaaa 14461 gacaaccatc attcccccta aataaattaa aaaaactatt aaacccatat aacctccccc 14521 aaaattcaga ataataacac acccgaccac accgctaaca atcaatacta aacccccata 14581 aataggagaa ggcttagaag aaaaccccac aaaccccatt actaaaccca cactcaacag 14641 aaacaaagca tacatcatta ttctcgcacg gactacaacc acgaccaatg atatgaaaaa 14701 ccatcgttgt atttcaacta caagaacacc aatgacccca atacgcaaaa ttaaccccct 14761 aataaaatta attaaccact cattcatcga cctccccacc ccatccaaca tctccgcatg 14821 atgaaacttc ggctcactcc ttggcgcctg cctgatcctc caaatcacca caggactatt 14881 cctagccatg cactactcac cagacgcctc aaccgccttt tcatcaatcg cccacatcac 14941 tcgngacgta aattatggct gaatcatccg ctaccttcac gccaatggcg cctcaatatt 15001 ctttatctgc ctcttcctac acatcgggcg aggcctatat tacggatcat ttctctactc 15061 agaaacctga aacatcggca ttatcctcct gcttgcaact atagcaacag ccttcatagg 15121 ctatgnncnc ccgnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna cnaactnnnn 15181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntactcagt 15241 agacagtccc accctcacac gattctttnn ntttcncttc atcttaccct tcattattac 15301 agccctagca gcactccacc tcctattctt gcacgaaacg ggatcaaaca accccctagg 15361 aatcacctcc cattccgata aaatcacctt ccacccttac tacacaatca aagacgccct 15421 cggcttactt ctcttccttc tctccttaat gacattaaca ctattctcac cagacctcct 15481 aggcgaccca gacaattata ccctagccaa ccccttaaac acccctcccc acatcaagcc 15541 cgaatgatat ttcctattcg cctacacaat tctccgatcc gtccctaaca aactaggagg 15601 cgtccttgcc ctattactat ccatcctcat cctagcaata atccccatcc tccatatatc 15661 caaacaacaa agcataatat ttcgcccact aagccaatca ctttattgac tcctagccgc 15721 agacctcctc attctaacct gaatcggagg acaaccagta agctaccctt ttaccatcat 15781 tggacaagta gcatccgtac tatacttcac aacaatccta atcctaatac caactatctc 15841 cctaattgaa aacaaaatac tcaaatgggc ctgtccttgt agtataaact aatacaccag 15901 tcttgtaaac cggagatgaa aacctttttc caaggacaaa tcagagaaaa agtctttaac 15961 tccaccatta gcacccaaag ctaagattct aatttaaact attctctgtt ctttcatggg 16021 gaagcagatt tgggtaccac ccaagtattg actcacccat caacaaccgc tatgtatctc 16081 gtacattact gccagccacc atgaatattg tacggtacca taaatacttg accacctgta 16141 gtacataaaa acccaatcca catcaaaacc ccctccccat gcttacaagc aagtacagca 16201 atcaaccttc aactatcaca catcaactgc aactccaaag ccacccctca cccactagga 16261 taccaacaaa cctacccacc cttaacagta catagtacat aaagccattt accgtacata 16321 gcacattaca gtcaaatcct ttctcgtccc catggatgac ccccctcaga taggggtccc 16381 ttgaccacca tcctccgtga aatcaatatc ccgcacaaga gtgctactct cctcgctccg 16441 ggcccataac acttgggggt agctaaagtg aactgtatcc gacatctggt tcctacttca 16501 gggtcataaa gcc //