LOCUS       HUMDNASEI               1039 bp    mRNA    linear   HUM 06-MAR-1995
DEFINITION  Human DNase I mRNA, complete cds.
ACCESSION   M55983
VERSION     M55983.1
KEYWORDS    DNase I.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1039)
  AUTHORS   Shak,S., Capon,D.J., Hellmiss,R., Marsters,S.A. and Baker,C.L.
  TITLE     Recombinant human DNase I reduces the viscosity of cystic fibrosis
            sputum
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (23), 9188-9192 (1990)
   PUBMED   2251263
COMMENT     Original source text: Human pancreus, cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..1039
                     /db_xref="H-InvDB:HIT000195815"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="hDNase-18-1"
                     /tissue_type="pancreas"
     gene            1..1039
                     /gene="DNase I"
     CDS             160..1008
                     /gene="DNase I"
                     /codon_start=1
                     /product="DNase I"
                     /protein_id="AAA63170.1"
                     /translation="MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLV
                     SYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERY
                     LFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPG
                     DAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLI
                     PDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYP
                     VEVMLK"
     sig_peptide     160..225
                     /gene="DNase I"
     mat_peptide     226..1005
                     /gene="DNase I"
                     /product="DNase I"
BASE COUNT          226 a          305 c          282 g          226 t
ORIGIN      
        1 tcctgcacag gcagtgcctt gaagtgcttc ttcagagacc tttcttcata gactactttt
       61 ttttctttaa gcagcaaaag gagaaaattg tcatcaaagg atattccaga ttcttgacag
      121 cattctcgtc atctctgagg acatcaccat catctcagga tgaggggcat gaagctgctg
      181 ggggcgctgc tggcactggc ggccctactg cagggggccg tgtccctgaa gatcgcagcc
      241 ttcaacatcc agacatttgg ggagaccaag atgtccaatg ccaccctcgt cagctacatt
      301 gtgcagatcc tgagccgcta tgacatcgcc ctggtccagg aggtcagaga cagccacctg
      361 actgccgtgg ggaagctgct ggacaacctc aatcaggatg caccagacac ctatcactac
      421 gtggtcagtg agccactggg acggaacagc tataaggagc gctacctgtt cgtgtacagg
      481 cctgaccagg tgtctgcggt ggacagctac tactacgatg atggctgcga gccctgcggg
      541 aacgacacct tcaaccgaga gccagccatt gtcaggttct tctcccggtt cacagaggtc
      601 agggagtttg ccattgttcc cctgcatgcg gccccggggg acgcagtagc cgagatcgac
      661 gctctctatg acgtctacct ggatgtccaa gagaaatggg gcttggagga cgtcatgttg
      721 atgggcgact tcaatgcggg ctgcagctat gtgagaccct cccagtggtc atccatccgc
      781 ctgtggacaa gccccacctt ccagtggctg atccccgaca gcgctgacac cacagctaca
      841 cccacgcact gtgcctatga caggatcgtg gttgcaggga tgctgctccg aggcgccgtt
      901 gttcccgact cggctcttcc ctttaacttc caggctgcct atggcctgag tgaccaactg
      961 gcccaagcca tcagtgacca ctatccagtg gaggtgatgc tgaagtgagc agcccctccc
     1021 cacaccagtt gaactgcag
//