LOCUS HUMIBP3 10884 bp DNA linear HUM 04-APR-2002 DEFINITION Homo sapiens growth factor-binding protein-3 precursor (IGFBP3) gene, complete cds. ACCESSION M35878 J05537 J05538 M35879 M35880 M35881 M35882 M35883 M35884 M35885 M35886 M36121 M36122 VERSION M35878.1 KEYWORDS insulin-like growth factor binding protein 3. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 10884) AUTHORS Cubbage,M.L., Suwanichkul,A. and Powell,D.R. TITLE Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity JOURNAL J. Biol. Chem. 265 (21), 12642-12649 (1990) PUBMED 1695633 COMMENT On Apr 4, 2002 this sequence version replaced M36121.1. Draft entry and computer-readable sequence kindly submitted by D.R.Powell, 03-JUL-1990. FEATURES Location/Qualifiers source 1..10884 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="HL1006d" /cell_type="leukocyte" gene 102..10775 /gene="IGFBP3" regulatory 102..1905 /regulatory_class="promoter" /gene="IGFBP3" /note="G00-126-724" protein_bind 1808..1821 /gene="IGFBP3" /note="G00-126-724" /bound_moiety="Sp1 and AP-2" regulatory 1876..1881 /regulatory_class="TATA_box" /gene="IGFBP3" /note="G00-126-724" mRNA join(1906..2440,5726..5952,6497..6616,8212..10775) /gene="IGFBP3" /product="growth factor-binding protein-3" exon 1906..2440 /gene="IGFBP3" /note="G00-126-724" /number=1 CDS join(2038..2440,5726..5952,6497..6616,8212..8337) /gene="IGFBP3" /note="The AAs encoded by bases 5728-5736 and 5917-5926 may be ASN-linked glycosylation sites; insulin-like precursor" /codon_start=1 /product="growth factor-binding protein-3 precursor" /protein_id="AAA52706.1" /db_xref="GDB:G00-126-724" /translation="MQRARPTLWAAALTLLVLLRGPPVARAGASSGGLGPVVRCEPCD ARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEAR PLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRV SDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREME DTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYT TKGKEDVHCYSMQSK" sig_peptide 2038..2118 /gene="IGFBP3" /note="G00-126-724" mat_peptide join(2119..2440,5726..5952,6497..6616,8212..8334) /gene="IGFBP3" /product="growth factor-binding protein-3" /note="G00-126-724" exon 5726..5952 /gene="IGFBP3" /note="G00-126-724" /number=2 exon 6497..6616 /gene="IGFBP3" /note="G00-126-724" /number=3 exon 8212..10775 /gene="IGFBP3" /note="G00-126-724" /number=4 regulatory 10751..10756 /regulatory_class="polyA_signal_sequence" /gene="IGFBP3" /note="G00-126-724" BASE COUNT 2796 a 2578 c 2737 g 2773 t ORIGIN 1 ctgcagacct gggacctcaa gaattgcatt tgatgccgaa cccagctcta atttcagagt 61 caaggtctct gcgagtattt aaggaacgga tgtaaacctg ggggattcgt tttgtttcct 121 tcaattttcc aatgaaatca gagatcctgt tcttgggtgt caacgcagat actagaagga 181 ggtgatacaa gagaaaggaa acagcaagcg acgattatgg cacggtttcc tgtaaacaag 241 gttgagtgta gccacagcct gagcactgtg ggagaagagc tcataagaaa atgacggtgc 301 tgggccttcg tcaccccggg gccctccatt gttcttgtct ttggtctctt tttatttgta 361 gaggtccaat tatttattta tttagtacaa gagggaacga aattgatctt tccattctaa 421 aaggagagta tatatgtata aaaggaagct gtatagatat gggggaagag gtggacaggg 481 ggaaaagggg agaggacgag agagagaaag ggagggagag ggacaaggag agacactggg 541 cgagagatcg attaggagag acagaaatga tgaatgaaga ttaacttcac ccaaggcttc 601 gtcgctggag gggaatggag gagctcctga tttgctatta ctactccaaa ctgcaaaggg 661 ctccttcaag tcacctatcc acctcctaag gcaagcgtcc aatttcaaca gcgttcagga 721 aagtctcctc ccgcggaggt ctcaccgctt cccactccac ccccacaaac tctttggaaa 781 agtgccttga aaaatttaat cctcaatcca atcctggacc accagcgtcc tctgttggtc 841 accgaaggag ggggtgcgca gacaaaactg aagaaactcg agtgccagag aaggccgaca 901 ggagttacag cgacctcagc gcgcaattgc gccccgaact ttactgaaaa gtgtttagat 961 tgcagagata agctagaatc ccaacgcatc gagaatacag taatacgaag tcgccttcaa 1021 aaaatgacaa tgaaaattgc ctattaaagg actatttggt taattacgtt tcagcagtgc 1081 ccagtttatt gtctttatta ttcttttgtc gtgggtgtaa actccatttg aaaacataat 1141 cagggagaat acccaagaca agaagaacag ttgtcattta aaatatttga aaagccctgc 1201 cttaaggagc attcgcttgc cggtccactc ttaattgggg acttgcggtg tagcaacacg 1261 tgagagtctt cttgcgttga gaagtaagcc tggaaaggcg aaggccccgg ggcatcttca 1321 gatgcgtatt tgtgggcccc tggggatata aacagcccag cgggtgtaaa ttaaaccccg 1381 cagtgccttg gctccctgag acccaaatgt aagtcagaaa tgtcccaaga cttcgcctgc 1441 caacggaatt aaattttaga aagctccacg aggtacacac gaatgcggag cgctgtatgc 1501 cagtttcccc gacaccggct cgccgcaggg agacctcacc ccgagagcgg aaggggtaag 1561 ggcggcgggg tcaaggagat cgggggtgct gagttggcca ggagtgactg gggtgaccgg 1621 gggtgctgag gtggcctgga gtgccggggt ggccgggcac accttggttc ttgtagacga 1681 caaggtgacg ggctccgggc gtgagcacga ggagcaggtg cccgggcgag tctcgagctg 1741 cacgcccccg agctcggccc cggctgctca gggcgaagca cgggccccgc agccgtgcct 1801 gcgccgaccc gcccccctcc caacccccac tcctgggcgc gcgttccggg gcgtgtcctg 1861 ggccaccccg gcttctatat acgggccggc gcgcccgggc cgcccagatg cgagcactgc 1921 ggctgggcgc tgaggatcag ccgcttcctg cctggattcc acagcttcgc gccgtgtact 1981 gtcgccccat ccctgcgcgc ccagcctgcc aagcagcgtg ccccggttgc aggcgtcatg 2041 cagcgggcgc gacccacgct ctgggccgct gcgctgactc tgctggtgct gctccgcggg 2101 ccgccggtgg cgcgggctgg cgcgagctcg gggggcttgg gtcccgtggt gcgctgcgag 2161 ccgtgcgacg cgcgtgcact ggcccagtgc gcgcctccgc ccgccgtgtg cgcggagctg 2221 gtgcgcgagc cgggctgcgg ctgctgcctg acgtgcgcac tgagcgaggg ccagccgtgc 2281 ggcatctaca ccgagcgctg tggctccggc cttcgctgcc agccgtcgcc cgacgaggcg 2341 cgaccgctgc aggcgctgct ggacggccgc gggctctgcg tcaacgctag tgccgtcagc 2401 cgcctgcgcg cctacctgct gccagcgccg ccagctccag gtgagccgcc cgccaggtgc 2461 gctgcgtgca gcaccgccac tggcgccgaa gggcctgggg gttgctgggt gccgctgcgg 2521 gagactccgc ttttcttctc actggagata atatgtgggg aaactgaagg cgctccggga 2581 aaggtgaagg cggtcgccga gggaccctcc ccagccggcc ctctacttgc tcgattctct 2641 aagtgcagag tacttgtaaa ttgcaaagcg ctttcagtga aaatgggtaa aggtttccgg 2701 agctgagggg agcggtaccg atgtttagct gttggaaaga tcctggacac aggagattct 2761 cctcgccccg cacgggtgca cacggactgc aatcccaggg atgcttgggg atggggggat 2821 ataggcggat ttggaccaag gaaggtgggt aggcacgttg taggaaatag tacctctctt 2881 ttaaaatact gactttgcac agccttttgg tttgcaaagc aatgtctagt cccggtatgt 2941 ccaaaaacaa gtaaagtgga ttcgggtttt gatatcttct gcggttggaa aacctgaagc 3001 tgaaaaagaa gtaacttctt aaggttaccc agcggccaca acagagtgta ggtttgaact 3061 ccgcgtgcca ctttcagtac cataccattc ttacaactcg ggccacccct gcacctgcgc 3121 cgacctcaaa caaacttcca ggtgcgtggt gggtgcgggc aatgtggact aagtcaattt 3181 caatgacacg gcaagggaat tggaatcagt cctaggctgt ctcccttctt aatctgaaat 3241 gggggggggg aatgagatgt tgttaagggg agccccagaa gaggaaaaat gcaaacattt 3301 ggcagagtta ccctcttgct tagccactat cagtatcagg cagacagcga ctctggtaag 3361 ggcatcacat tgttccctta aaaaaaggag cgggggttgt ttaaatggat ttggcagctg 3421 ttctttcaag cattcttagc cagcctcacc tagttatatg agaaataaag ttcctgcctt 3481 gcacagctga aggctgggag aattctcccc atcctaattc ccccaactcc ccaacgatca 3541 cgttggacag atgtcactgg gcaggccccc atctagggct agcaggatga acagtccctt 3601 tataatttat gtagctgtag agttccacgc ccgggtgaag ttattttctg gctcggcaag 3661 gctggctctg ttcacccctg agaaatgctg gattcatgga aaggcaagat gcctgaaaca 3721 tacactggct ctggtcagct gttaaagctg ctggaggcat ttgtctctcg gggcaaagtt 3781 atgtcatttg ccaagtgtcg tacattattg tgcattttgg ggtattcaaa aagtgatctt 3841 agaaatactg atacacatcg tcattcttgg gctttagcaa tcatcatgat taccacctta 3901 gtagcactgt agtataggtt gatgtgagtt ataagattat aaaaagatct aagtgacttc 3961 tagaatctat ttgacaaaaa aaggtaaatt ttcgacagtc aaaagtcaca attatctgtt 4021 gcttaaatag aactgttttg tcttcatgcc ctagtctgca gcccaggcat taagaagaaa 4081 ccaaggaaat ttaagaaatt actcaaggtt cttagaaaag aagtataaat acgtttattt 4141 acatgttctt agagtattta cattcttagt atctctttta tctcagtatt tccttgaaaa 4201 agaaagcaag ctaagattaa aagaaattga aaccaaatcc tcgcaggtag ggacctcctc 4261 tgtgaggctc tgtgctggac cctgggaatg tgtgcttccc aaggtatgaa accccttggg 4321 gaactttaca gcaggacctc agtgagctgt ttggcaggtg aggaaactaa gacccagaga 4381 ggagagggac tttcctaagg ccctggtgag tgacctgcca gtagccactt ccaggggaga 4441 gcagagcatc tgcagccaaa tcattgcagc cccaggtagc tttctagata gactgtggac 4501 cagatgggcc acctgagctc cctgctaggg ttacacatta tagccctgtt tgtgtagtag 4561 agaaatttca tgactctcaa ttgtggactt aagccgatgc ctccagacct tggcatggtc 4621 cacaggccct gggagcatgg gctctgaatg tagcctttga tccccatagc ggtcttacag 4681 cccctccaag ttcattctga agaaggaatg gagtgagaat cctggctgca gatccagtct 4741 tgaatttagt catatactta aaattccaat tcaactgtta acattccagc atccatttta 4801 agcatcagac tttcttcatt tagcactttt tattataaaa gggagatctg ctggaggggg 4861 atttctccta ccccaccccc acccagggaa ggaaaagctc tttggcactt agaagtctga 4921 gccgtgagtg ggactttggc attgtctgca tccatgtgct gctgtgttca cccggggtga 4981 aaaggactca cttaggcagg caccagcaag atgcacaggg tctgtgtaga ccttgagttt 5041 tagagatgta acggggacct agaaaacaag ccaccaacat gcttgcatga ttctgagccc 5101 ctgaggcaaa acgctttgca ggtaataatt cagttttccc atctgagctg gacaccaagc 5161 tcttataagc gtgtttacct ggtagcattg aggacggtac tggtcaacct tggaattccc 5221 ataagggctt gttacaactc agactcgtgc cgccactcca gcgtttccgg agtggagaat 5281 gtgcatttct tccaagtccc cgggctgccg ctgctcccgc gggtgggagg accacacttg 5341 gagttgactg caaaatttct gagccggcgc tgcagcagcc tcccgtggct caggtctgcc 5401 ccctgccggt ggaagatgaa gcatactgcc ttcacctact gaggggcact gaagcgtttg 5461 tctgccttct ttagttgcag ctacttagga agagcacctg tcagattgac tttcaaacag 5521 ataacttctt gaggtagagc aaccaccatg tagtgagtag tatgatggaa taatacttca 5581 tcgaggtatt taaaaaaaaa acctcacttg gattgccaac taatattgtc atttacatgt 5641 gacctggttg caacgttaag atttttacaa gactgtgata gatattgatg actctcatgt 5701 gtttgtctct cttgggcgtt ttaaggaaat gctagtgagt cggaggaaga ccgcagcgcc 5761 ggcagtgtgg agagcccgtc cgtctccagc acgcaccggg tgtctgatcc caagttccac 5821 cccctccatt caaagataat catcatcaag aaagggcatg ctaaagacag ccagcgctac 5881 aaagttgact acgagtctca gagcacagat acccagaact tctcctccga gtccaagcgg 5941 gagacagaat atgtgagagc ttttcctctt gttaaaggag gagggcaaga cctgccaagc 6001 ctgggtactc agagcctctt gagggcaatt cttactcaac aaaccccagc gcctggctga 6061 tgggtgggca acccctagcc cctctgtgcc ctacctctct cctctcctta cataaagaat 6121 attgaccctt ttggagaatc ttatgaggat caagctgaaa taacactctt aaaagcatat 6181 gggatgtcat aaagacctct gcagataatg aaaatattct cataaagata gttttattta 6241 cttcatcctc tatgcttgtt gacctgctat tggttccatg ccagcttctg tgccttactc 6301 tgggaagagc aaaaaggaga cagggagtga tggttagctt attcggggga ctttcgtgct 6361 acatcagaca taaggtatct gaggagcaaa ttacaggtcc cacttttggt agttgtgcag 6421 catcgtaaga tttttaaagc acacattcta gagtaaaaac tgtgactctg ttgctctggt 6481 ccttcctgat ccccagggtc cctgccgtag agaaatggaa gacacactga atcacctgaa 6541 gttcctcaat gtgctgagtc ccaggggtgt acacattccc aactgtgaca agaagggatt 6601 ttataagaaa aagcaggtga gtgaggtcct cagtgtgttt tcttcctctt ctgttgacac 6661 agaggagaaa cccatgtcac cagcgcccag gctcttgtgg ccatagctct aactctgagc 6721 ctgtgcagca ccagtgccca ggacttggtg ccagtctcag gaggtcagac caagggctgc 6781 tttgacttgt tgctctgagt gctgctatat tggccataat cctcaaccct agtgcctttc 6841 caccacccgc ttcccactcc tgtcctttca atggttcacc cacaggcgga caagatgctg 6901 cccagtggca ccctttataa actgcaagtg gacatgttaa cacatttgtt aatgctgcgt 6961 cagggagtga catttcaaac aactattata gtcagtttcc aagaagtgtg acatgaggtc 7021 ataccacaaa aaagcttacc ctgaaatccc acaatcgtcc cctttcctac tgatgccttc 7081 ccgatagtga gcaggttgca atattaagat tttgaaaagg ctgttgctag atgttggtga 7141 ctcgtgtgtc tctgtctccc ttgggctttt caaggaaatg ctagtgagtg gggggatgac 7201 tgcagcatgg ccagcttgga gagcccagcc atccccagca cataccaggt gtctgtcttg 7261 gcgtggaggg gatggaactt gaaatcagac actcggtcca tgctggggat ggccagtctc 7321 tccaaactgg catgtggtct tcctccgagt cactggcatt tccctagaaa gtccaagtga 7381 gaagaaggca tgagagtcat caacatcaaa caacagtctt ttcaaaatct ttatattgca 7441 acatagtccc attcctggaa aaggaatgga gtgagaatcc tggctacaca tcagccccaa 7501 atgtagtcat tgcctaaaat cccaattaac ctgaaaatga tcaaacaaat ttaagatata 7561 gtaatattaa gctgtaataa atatgcttct ataggctttg tgttatgtga tggcactatt 7621 tcaattggct ttctaattgg acaattgata ctatgctatc tacagaattg gcctttggag 7681 acctaagtga gccacagtgg cctcagggtg accatatact aggattcata gcagtggcca 7741 cagtcagaag cctaagcttt cctccattgc cattgctcgt ttataccacg tttctgtcaa 7801 agtcatattc attcaacaaa gtcatactga gaaggtgtca tgtgaggctg gatgtgggct 7861 ccaaagtcat agctgtgaca ttcgcaggca gcgggatgtt ctcagttcca catttggcag 7921 agaagtcagt caagaggttc tacaagggct ggtgtccacc ttatactcct agaaacacaa 7981 aactgccccc acccccgctt tcttggagca ggaagttaca cccacacgca tgcacaggcg 8041 cacactcagc gggcctaggc agcgtggctc ttgtgttgcc ttagctgaaa tttctgttgt 8101 gctttctcag catagcagag tcacgctggc aaaccatcat gcgccctggc caccgacctg 8161 acaccagacc caggagcatt cacttctctg tcttctgttt ctctcccaca gtgtcgccct 8221 tccaaaggca ggaagcgggg cttctgctgg tgtgtggata agtatgggca gcctctccca 8281 ggctacacca ccaaggggaa ggaggacgtg cactgctaca gcatgcagag caagtagacg 8341 cctgccgcaa gggtgagtac tcaggagggg cagcctgggc tccagggcct cactgtcctt 8401 ggaccagcct caggggctgg gcgtggccac tggccttccc caggcttaca gacccaggag 8461 ctgcagctca gggccagaaa gagcaaagca aataggacag agccctcaga agggtgcagg 8521 gagagggaga ccccatcaac ccaaccaaac aagtgtgggg aaggaggccg gccagtgcac 8581 ctcagggaca ctctgcttta tctcagatac ctcacagcac ctaagctatc attcatccac 8641 acacaaagtg aagattttca aagttaggct ttacccgtga gtctggaggt catttatctt 8701 cacagagaac gtttatcgca gactgctaag atacatgttc taattaagat gtgatgtgag 8761 aacgctgaat gctcgttgga gactcagttg aagtgcagct ttttttctgt caaatatata 8821 atgaatattc tgttagtctg tggctaatat aattttaata aagttaattt aaatctgata 8881 gaaaaatgaa attttaaacg ataattttag agaatgctat tatatccagt cttctttttt 8941 cttttaataa atgagggaac tattggggga aaggaataaa tacattttct ttcattttat 9001 taagacaaat ttagtaagca gaagaaattt gcatgtttag ttataagggt ttcttttttc 9061 cttacaagtt ggaaaaaata attctaattt aagggtaact ctttgacaat gaacactgtg 9121 agcagcatct ggtactcgtt gctttgtttg aaaacatgag ttgagacccc agccgcactt 9181 gcagcctagt gccattagcc tgcaggctgt gctggatatc tcagggcaag agtcgagccc 9241 ttttgatttt ggggggatta tttcaatata tttgcttttt ctttttgttt tagttaatgt 9301 ggagctcaaa tatgccttat tttgcacaaa agactgccaa ggacatgacc agcagctggc 9361 tacagcctcg atttatattt ctgtttgtgg tgaactgatt ttttttaaac caaagtttag 9421 aaagaggttt ttgaaatgcc tatggtttct ttgaatggta aacttgagca tcttttcact 9481 ttccagtagt cagcaaagag cagtttgaat tttcttgtcg cttcctatca aaatattcag 9541 agactcgagc acagcaccca gacttcatgc gcccgtggaa tgctcaccac atgttggtcg 9601 aagcggccga ccactgactt tgtgacttag gcggctgtgt tgcctatgta gagaacacgc 9661 ttcaccccca ctccccgtac agtgcgcaca ggctttatcg agaataggaa aacctttaaa 9721 ccccggtcat ccggacatcc caacgcatgc tcctggagct cacagccttc tgtggtgtca 9781 tttctgaaac aagggcgtgg atccctcaac caagaagaat gtttatgtct tcaagtgacc 9841 tgtactgctt ggggactatt ggagaaaata aggtggagtc ctacttgttt aaaaaatatg 9901 tatctaagaa tgttctaggg cactctggga acctataaag gcaggtattt cgggccctcc 9961 tcttcaggaa tcttcctgaa gacatggccc agtcgaaggc ccaggatggc ttttgctgcg 10021 gccccgtggg gtaggaggga cagagagacg ggagagtcag cctccacatt cagaggcatc 10081 acaagtaatg gcacaattct tcggatgact gcagaaaata gtgttttgta gttcaacaac 10141 tcaagacgaa gcttatttct gaggataagc tctttaaagg caaagcttta ttttcatctc 10201 tcatcttttg tcctccttag cacaatgtaa aaaagaatag taatatcaga acaggaagga 10261 ggaatggctt gctggggagc ccatccagga cactgggagc acatagagat tcacccatgt 10321 ttgttgaact tagagtcatt ctcatgcttt tctttataat tcacacatat atgcagagaa 10381 gatatgttct tgttaacatt gtatacaaca tagccccaaa tatagtaaga tctatactag 10441 ataatcctag atgaaatgtt agagatgcta tatgatacaa ctgtggccat gactgaggaa 10501 aggagctcac gcccagagac tgggctgctc tcccggaggc caaacccaag aaggtctggc 10561 aaagtcaggc tcagggagac tctgccctgc tgcagacctc ggtgtggaca cacgctgcat 10621 agagctctcc ttgaaaacag aggggtctca agacattctg cctacctatt agcttttctt 10681 tattttttta actttttggg gggaaaagta tttttgagaa gtttgtcttg caatgtattt 10741 ataaatagta aataaagttt ttaccattaa aaaaatatct ttccctttgt tattgaccat 10801 ctctgggctt tgtatcacta attattttat tttattatat aataattatt ttattaaaat 10861 gttccctgct ttccctttta gcaa //