LOCUS AH003534 7125 bp DNA linear HUM 28-JUL-2016 DEFINITION Homo sapiens butyrylcholinesterase (BCHE) gene, complete cds. ACCESSION AH003534 J02879 M32388 M32389 M32390 M32391 VERSION AH003534.2 KEYWORDS butyrylcholinesterase. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 2255 to 2599; 2700 to 5381; 5482 to 6101; 6202 to 7125) AUTHORS Arpagaus,M., Kott,M., Vatsis,K.P., Bartels,C.F., La Du,B.N. and Lockridge,O. TITLE Structure of the gene for human butyrylcholinesterase. Evidence for a single copy JOURNAL Biochemistry 29 (1), 124-131 (1990) PUBMED 2322535 REFERENCE 2 (bases 1 to 7125) AUTHORS Jbilo,O., Toutant,J.P., Vatsis,K.P., Chatonnet,A. and Lockridge,O. TITLE Promoter and transcription start site of human and rabbit butyrylcholinesterase genes JOURNAL J. Biol. Chem. 269 (33), 20829-20837 (1994) PUBMED 8063698 REFERENCE 3 (bases 1 to 2599) AUTHORS Chatonnet,A. TITLE Direct Submission JOURNAL Submitted (18-NOV-1989) A. Chatonnet, Departement de Physiologie Animale, Institut National de la Recherche Agronomique, Place Viala, 34060 cedex 1, Montpellier, France REFERENCE 4 (bases 2255 to 2599; 2700 to 5381; 5482 to 6101; 6202 to 7125) AUTHORS Lockridge,O. TITLE Direct Submission JOURNAL Submitted (18-NOV-1989) O. Lockridge, Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109-0626 COMMENT On or before Apr 6, 2016 this sequence version replaced M32388.1, M32389.1, M32390.1, M32391.1, AH003534.1. FEATURES Location/Qualifiers source 1..7125 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /map="3q26" /cell_type="white blood cell" gene 2292..6910 /gene="BCHE" mRNA join(2292..2440,2834..4358,5691..5857,6307..6910) /gene="BCHE" /experiment="experimental evidence, no additional details recorded" exon 2292..2440 /gene="BCHE" /note="G00-120-558" /number=1 variation 2417 /gene="BCHE" /note="g in wild-type; a in variant (Cys->Tyr)" /replace="a" intron 2441..>2599 /gene="BCHE" /note="G00-120-558" /number=1 gap 2600..2699 /estimated_length=unknown intron <2700..2833 /gene="BCHE" /note="G00-120-558" /number=1 exon 2834..4358 /gene="BCHE" /note="G00-120-558" /number=2 CDS join(2842..4358,5691..5857,6307..6431) /gene="BCHE" /EC_number="3.1.1.8" /note="precursor" /codon_start=1 /product="butyrylcholinesterase" /protein_id="AAA99296.1" /db_xref="GDB:G00-120-558" /translation="MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGM NLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFP GFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKF LARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPK SVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAK LTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDIL LELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEF GKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFE HRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDE AEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL" sig_peptide 2842..2925 /gene="BCHE" /note="G00-120-558" mat_peptide join(2926..4358,5691..5857,6307..6428) /gene="BCHE" /product="butyrylcholinesterase" /EC_number="3.1.1.8" /note="G00-120-558" variation 3134 /gene="BCHE" /note="a in wild-type; g in atypical variant (Asp-> Gly)" /replace="g" variation 3275..3277 /gene="BCHE" /note="gtt in wild-type; gagt in silent variant" /replace="gagt" variation 4094 /gene="BCHE" /note="g in wild-type; t in variant (Gly->Val)" /replace="t" intron 4359..>5381 /gene="BCHE" /note="G00-120-558" /number=2 gap 5382..5481 /estimated_length=unknown intron <5482..5690 /gene="BCHE" /note="G00-120-558" /number=2 exon 5691..5857 /gene="BCHE" /note="G00-120-558" /number=3 intron 5858..>6101 /gene="BCHE" /note="G00-120-558" /number=3 gap 6102..6201 /estimated_length=unknown intron <6202..6306 /gene="BCHE" /note="BChE intron C" exon 6307..6910 /gene="BCHE" /note="G00-120-558" /number=4 variation 6321 /gene="BCHE" /note="g in wild-type; a in K variant (Ala->Thr)" /replace="a" variation 6620 /gene="BCHE" /note="a in wild-type; g in variant" /replace="g" BASE COUNT 2205 a 1142 c 1202 g 2276 t ORIGIN 2360 bp upstream of PvuII site; chromosome 3q21-25. 1 cagctgctgc tgtaagttga gccacaagga agaaactcta agacaggaag aataaatgct 61 ttagaggtgc actaaaataa tgaatgaact aatgtggcat agctgtgaaa tcatgcgagg 121 aaaagaacta cagggacagt aacagaaggt ggttctttga agtaaagaca ttgagaagaa 181 gaaaaattgc caacttgtgt aatcagttga tgttgctagt tagccagttt aaacatgcgt 241 taaagataaa gatctgcttg aaaccaatta ttttattgtt tggcttcctg tttaaagatg 301 aaaatgaaat atgtgtatat atgtgacata ttttacctag cagtgagtag atgcaggaag 361 catgtaaaat gctctgctga attcactaac gtcacaaaat attccttaat aattgccgcg 421 tttgataggc tgaccgtatg ctagcacagg aaacaatgca gtggacttgg gttggagaga 481 agaattttga catttggatt tttaaaaatc atgtatattg aacccatgaa ctctcatgtg 541 gaacatcaga tttactatat tttaaacaga aatgcccatc actataaaaa ccattgcaaa 601 tttgtcaata tacttcccat ttaaaaagcc ttttcctgct tttattgatt tattgattaa 661 tttttttttg agacaggatc tcactctgtc acccacgatg aagtccagtg gcacaatcgt 721 ggcttgcagc ctcgacctcc taggctcagg tgatactctt acctcagcta cctcccaagt 781 aactgggaat gtaggcttgc accaccatgt ctgacccatt ttcttgcaga aattgagttt 841 tgctatgttg tccagacttg tcttgaactc ccagactgaa gcaatccgcc cacttaggcc 901 tcctaaaatg ttgggattac agctatgaac cactgtgctc cacctccttt ttctcctttt 961 cagatagatt gtgtattctg taccttttgt gtaactaact tgttattaca taaactatat 1021 tctaaataca ttataaatta ttgtgatcat gatatttatc attgaattaa cactgcctaa 1081 gtagcaattt tcacagaaaa gataatttta aaagaccaaa atggttattc tcttggaagc 1141 agttgacata aaataacaga ataatacaga ttaaaattct gttttccaac agctactagt 1201 ggtaagaaat atagtaagct tctgatttgt agaaacctta gctttctcat ctgatgaggt 1261 ggttaataat attaactctc atatttgctg aaataatata aaatatttaa tcataaattg 1321 tcaattataa tgactggcat aaggtagaat tacaccaaat gctaacttat atttgcttgt 1381 ttgaaaattt aacactctat taaaaggcaa aaaagtgctc cacctgcaaa tattaataca 1441 tgccttctgt ttagtccata cgaataagcc acaagtaaga gattcaaaag tgaaagctat 1501 cacttacaga agattaagaa tatattgcat tgagaagata gggattaagg agttcatcaa 1561 aggtttttta aaaaattatt ttcctgaaca tcatttcaag aaagataagc gccaaagaca 1621 taaatatatt ctccagagca tgtgcactgc aagttgacaa atgtgtctct tttatagagt 1681 ttggtgaagg ttattcattt tatttttcct gtcttgacca gaaaattgtg gtttctcatc 1741 atgtatgact gcctgcaggg tcttctgaat aggaaattac caatgctgaa atttgtatga 1801 cttaaataag tgttgaagtg tgggggttga aaggagatac atatcagaga catccattca 1861 gttaatagaa ctaagttttt gatttgcata gcttatatct agagcattgt gtttcttatt 1921 ttctatatta ctatcttctc taactatata attagcacag attgaagcta taatggattt 1981 caataatagc actactttag aatgatgtat acgtctttaa atcttaagac aagcatagga 2041 aatatgtata ttcttaaaaa aagaaaattt ttttaaagtt tagagttaaa agaaacatgc 2101 attttctgtt acatttcaga ttattttagt taaagaatct tctatgcttt ttttcttcat 2161 tcttagaaga ctacctgcaa ttgtaaagca tgaatcctgt aatacttctg taaatgaatc 2221 actattgcat ttataccatt agcctctgaa cagatttcaa gttgctgctg ccaactctcg 2281 cgagctttgt cagtaacagt tgattgttac attcagtaac actgaatgtc agtgcagtcc 2341 aatttacagg ctggagcagc agctgcatcc tgcatttccc cgaagtatta catgattttc 2401 actccttgca aactttacca tctttgttgc agagaatcgg gtaagttgct ctgaatttac 2461 accttcgtgt agagatccaa gttactgtaa agctcattct gtgggatgag agtgatctct 2521 tcatgtgttt gttgtgtccc tttggtgctc tgtggggaac agttactgaa gcttgcaaat 2581 gggacagagg aagtgagccn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt 2701 ttacagaatc aggtttattt gtttcataat ttgtagaatt atcaagcatc atattttagg 2761 taattatcat caataaagta taatatgcta tatgcagaag gcttataaaa cattatactt 2821 acctctcttt cagaaatcaa tatgcatagc aaagtcacaa tcatatgcat cagatttctc 2881 ttttggtttc ttttgctctg catgcttatt gggaagtcac atactgaaga tgacatcata 2941 attgcaacaa agaatggaaa agtcagaggg atgaacttga cagtttttgg tggcacggta 3001 acagcctttc ttggaattcc ctatgcacag ccacctcttg gtagacttcg attcaaaaag 3061 ccacagtctc tgaccaagtg gtctgatatt tggaatgcca caaaatatgc aaattcttgc 3121 tgtcagaaca tagatcaaag ttttccaggc ttccatggat cagagatgtg gaacccaaac 3181 actgacctca gtgaagactg tttatatcta aatgtatgga ttccagcacc taaaccaaaa 3241 aatgccactg tattgatatg gatttatggt ggtggttttc aaactggaac atcatcttta 3301 catgtttatg atggcaagtt tctggctcgg gttgaaagag ttattgtagt gtcaatgaac 3361 tatagggtgg gtgccctagg attcttagct ttgccaggaa atcctgaggc tccagggaac 3421 atgggtttat ttgatcaaca gttggctctt cagtgggttc aaaaaaatat agcagccttt 3481 ggtggaaatc ctaaaagtgt aactctcttt ggagaaagtg caggagcagc ttcagttagc 3541 ctgcatttgc tttctcctgg aagccattca ttgttcacca gagccattct gcaaagtgga 3601 tcctttaatg ctccttgggc ggtaacatct ctttatgaag ctaggaacag aacgttgaac 3661 ttagctaaat tgactggttg ctctagagag aatgagactg aaataatcaa gtgtcttaga 3721 aataaagatc cccaagaaat tcttctgaat gaagcatttg ttgtccccta tgggactcct 3781 ttgtcagtaa actttggtcc gaccgtggat ggtgattttc tcactgacat gccagacata 3841 ttacttgaac ttggacaatt taaaaaaacc cagattttgg tgggtgttaa taaagatgaa 3901 gggacagctt ttttagtcta tggtgctcct ggcttcagca aagataacaa tagtatcata 3961 actagaaaag aatttcagga aggtttaaaa atattttttc caggagtgag tgagtttgga 4021 aaggaatcca tcctttttca ttacacagac tgggtagatg atcagagacc tgaaaactac 4081 cgtgaggcct tgggtgatgt tgttggggat tataatttca tatgccctgc cttggagttc 4141 accaagaagt tctcagaatg gggaaataat gcctttttct actattttga acaccgatcc 4201 tccaaacttc cgtggccaga atggatggga gtgatgcatg gctatgaaat tgaatttgtc 4261 tttggtttac ctctggaaag aagagataat tacacaaaag ccgaggaaat tttgagtaga 4321 tccatagtga aacgttgggc aaattttgca aaatatgggt aagtgctgat tttttgtcat 4381 tgttctctgg cttggtttga tccgttttgc ttagctttgc ttggtctctg gggtagactt 4441 tagtataaag acacagaaat gttttaatta tttgttctat ttgtaccaaa gctggtttta 4501 ttttttctta tgaactgcat ttcaactccc tgtgtcagag tgtttaaatc atcatcttag 4561 acattttata cgaaaatatc ttctgatttc atctccaaaa tatttcaaag tatttcaaca 4621 atgttagcca aagtttttat agaaaaagat gcttagttgg agaactaaaa ttaatgtgag 4681 aatacttttt aacctgcaag tttacaatgt tcacagattt acgtcagagt aggactattt 4741 cttccaagct cttcgagctt ggtaccatga tacctgatac atgaagtaat gtatctctgc 4801 ttaggaaatt gaagggacat gatggtgatg cagttggccc tcagtttacc caaaatatac 4861 atttgccatt gtattgtttg gtttttcttt ttttcctaat aggcctgatc agatttgagg 4921 cagcctgtgt ttgactgggg ccatgagggt ttagctaagc cgttctccac ctgagcagtc 4981 ttatggctga cattagataa tcagagacat tacaaaaaac atatttcccc catatattat 5041 aagtattgtg atagtatgtc caaaagagtc agaaaaaata accatttaga atatattttc 5101 taaatatgta tgtgtatcta tagaaaataa agtagttttt ttttctccca ctacatttgt 5161 aaaccaaaac cacattttat acatgggagt aaattgcacc aatgtgaata atttaaaaaa 5221 aatagaaatt tagaaattta cttatacaag aaatgtttac ataaatcata agttgattga 5281 ttcagtaatt cagtctatca cactatcttt tataactaaa caaaatgccg atagttacat 5341 tattgctttc tggtgttctt ttccaccctc catttgaatt cnnnnnnnnn nnnnnnnnnn 5401 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5461 nnnnnnnnnn nnnnnnnnnn nttcaattct tacaatttta aataacatag tggttctcag 5521 tgctcaaacc actaagccca ggttcacata cgtttcatat catcaatata tatccacatt 5581 ttttctgtct taaattcttt aaagctctgt gaacagtgtt agaaaacaat attcttttta 5641 atctaacaat gatttcaatt ttactataat gtctctattt tattatttag gaatccaaat 5701 gagactcaga acaatagcac aagctggcct gtcttcaaaa gcactgaaca aaaatatcta 5761 accttgaata cagagtcaac aagaataatg acgaaactac gtgctcaaca atgtcgattc 5821 tggacatcat tttttccaaa agtcttggaa atgacaggtg tgtctgtttt tagtgtttgg 5881 ttatttaata gatgatgggt tatgtaaaaa agggatgaag tatactctcc aaggcacggt 5941 gatggagtta ctatatgtat ctctgacttt aaaataactt ggtttaatga acacattatt 6001 tttaagactt tcttctatca agtttagata tgttttgaac tcttactata tgaccagtac 6061 tttagtagtt aaataaagaa aactaaaata tagatttcac cnnnnnnnnn nnnnnnnnnn 6121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6181 nnnnnnnnnn nnnnnnnnnn nctgtactgt gtagttagag aaaatggctt ttgtattcga 6241 aattattttt cagttaatga aacagataaa aattttgatt aatacaactt attccatatt 6301 ttacaggaaa tattgatgaa gcagaatggg agtggaaagc aggattccat cgctggaaca 6361 attacatgat ggactggaaa aatcaattta acgattacac tagcaagaaa gaaagttgtg 6421 tgggtctcta attaatagat ttacccttta tagaacatat tttcctttag atcaaggcaa 6481 aaatatcagg agctttttta cacacctact aaaaaagtta ttatgtagct gaaacaaaaa 6541 tgccagaagg ataatattga ttcctcacat ctttaactta gtattttacc tagcatttca 6601 aaacccaaat ggctagaaca tgtttaatta aatttcacaa tataaagttc tacagttaat 6661 tatgtgcata ttaaaacaat ggcctggttc aatttctttc tttccttaat aaatttaagt 6721 tttttccccc caaaattatc agtgctctgc ttttagtcac gtgtattttc attaccactc 6781 gtaaaaaggt atctttttta aatgaattaa atattgaaac actgtacacc atagtttaca 6841 atattatgtt tcctaattaa aataagaatt gaatgtcaat atgagatatt aaaataagca 6901 cagaaaatca ttggtctctt tgttttttat ataaaggcaa gaaagaatct taaaatgaga 6961 ggctcagcca ctttaaaaca ccttataata agaaacagaa tgctgctacc aagaaacaaa 7021 atataaaata atgtaattat ttatgtaatg ccttcaaatt atattcttca tttgactctt 7081 gctctccctc acctcctcta tcctcaaatc accacaaaca tgtac //