LOCUS AH002608 2943 bp DNA linear HUM 10-JUN-2016 DEFINITION Homo sapiens amphiregulin (AREG) gene, complete cds. ACCESSION AH002608 M30698 M30699 M30700 M30701 M30702 M30703 VERSION AH002608.2 KEYWORDS amphiregulin; growth regulator; tumor inhibitory factor. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2943) AUTHORS Plowman,G.D., Green,J.M., McDonald,V.L., Neubauer,M.G., Disteche,C.M., Todaro,G.J. and Shoyab,M. TITLE The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity JOURNAL Mol. Cell. Biol. 10 (5), 1969-1981 (1990) PUBMED 2325643 COMMENT On or before Jun 10, 2016 this sequence version replaced M30698.1, M30699.1, M30700.1, M30701.1, M30702.1, M30703.1, AH002608.1. FEATURES Location/Qualifiers source 1..2943 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /map="4q13-q21" /cell_line="MCF-7" /tissue_type="breast carcinoma" gene 649..2883 /gene="AREG" exon 649..919 /gene="AREG" /note="G00-119-697" /number=1 CDS join(859..919,1119..1367,1568..1768,1969..2122,2322..2415) /gene="AREG" /note="precursor" /codon_start=1 /product="amphiregulin" /protein_id="AAA51773.1" /db_xref="GDB:G00-119-697" /translation="MRAPLLPPAPVVLSLLILGSGHYAAGLDLNDTYSGKREPFSGDH SADGFEVTSRSEMSSGSEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSV RVEQVVKPPQNKTESENTSDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECK YIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAIAAFMSAVILTAVAV ITVQLRRQYVRKYEGEAEERKKLRQENGNVHAIA" sig_peptide 859..915 /gene="AREG" /note="G00-119-697" mat_peptide join(1358..1367,1568..1768,1969..2009) /gene="AREG" /product="amphiregulin" /note="alternative mature peptide; G00-119-697" mat_peptide join(1576..1768,1969..2009) /gene="AREG" /product="amphiregulin" /note="alternative mature peptide; G00-119-697" intron 920..>968 /gene="AREG" /note="G00-119-697" /number=1 gap 969..1068 /estimated_length=unknown intron <1069..1118 /gene="AREG" /note="G00-119-697" /number=1 exon 1119..1367 /gene="AREG" /note="G00-119-697" /number=2 intron 1368..>1416 /gene="AREG" /note="G00-119-697" /number=2 gap 1417..1516 /estimated_length=unknown intron <1517..1567 /gene="AREG" /note="G00-119-697" /number=2 exon 1568..1768 /gene="AREG" /note="G00-119-697" /number=3 intron 1769..>1818 /gene="AREG" /note="G00-119-697" /number=3 gap 1819..1918 /estimated_length=unknown intron <1919..1968 /gene="AREG" /note="G00-119-697" /number=3 exon 1969..2122 /gene="AREG" /note="G00-119-697" /number=4 intron 2123..>2172 /gene="AREG" /note="G00-119-697" /number=4 gap 2173..2272 /estimated_length=unknown intron <2273..2321 /gene="AREG" /note="G00-119-697" /number=4 exon 2322..2433 /gene="AREG" /note="G00-119-697" /number=5 intron 2434..>2489 /gene="AREG" /note="G00-119-697" /number=5 gap 2490..2589 /estimated_length=unknown intron <2590..2639 /gene="AREG" /note="G00-119-697" /number=5 exon 2640..2883 /gene="AREG" /note="G00-119-697" /number=6 BASE COUNT 693 a 517 c 543 g 690 t ORIGIN 1 gaattcatat ccacctggct ttgaacatta tcggctgtga gatggtgtag gtaaaatttt 61 aagtgcataa tttggcaata ataaatcatc aataaatatt aatgttgatg aggcccctgg 121 gccacataaa gaaataggga gtgaggggat ttgaaattct ggccacttca cagaaatggg 181 tgggaagggg ctcttgattg agatagaagc ccatcctaca tgaagcaatt cctcattgag 241 ttctctcgtc ctttatcctt gttggaaaca tcaggcaaag tcactcttgg tcttaaagta 301 cttttacatc taaatacgga actcttctat ttaatccctg tctgttgtag atgttaagta 361 tacaaagagg ttgtcagagt ttgaaacatc tggacttctg tcaggtacta gctccggaac 421 tccagtcctg ctcgccctca aaaacggctt gcagctagag gtttaagttc cacttcctct 481 cagcgaatcc ttacgcacga gggaggcggg gcgtgtgtcc tccgcgcgtg gttttcgggt 541 agcaccttct ggggcgccgc ctgcctccac ccacggccgg gccttgacgt catgggctgc 601 ggccccctcc cggctgagcc tataaagcgg caggtgcgcg ccgccctaca gacgttcgca 661 cacctgggtg ccagcgcccc agaggtcccg ggacagcccg aggcgccgcg cccgccgccc 721 cgagctcccc aagccttcga gagcggcgca cactcccggt ctccactcgc tcttccaaca 781 cccgctcgtt ttgcggcagc tcgtgtccca gagaccgagt tgccccagag accgagacgc 841 cgccgctgcg aaggaccaat gagagccccg ctgctaccgc cggcgccggt ggtgctgtcg 901 ctcttgatac tcggctcagg tgaggattca acggcgctga actgctgggc tctcctccca 961 tggcaggtnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnag caccctactt 1081 taccttttcg ttttcttcct ttattccctc ccctgcaggc cattatgctg ctggattgga 1141 cctcaatgac acctactctg ggaagcgtga accattttct ggggaccaca gtgctgatgg 1201 atttgaggtt acctcaagaa gtgagatgtc ttcagggagt gagatttccc ctgtgagtga 1261 aatgccttct agtagtgaac cgtcctcggg agccgactat gactactcag aagagtatga 1321 taacgaacca caaatacctg gctatattgt cgatgattca gtcagaggtg agtaggggat 1381 aaagcaaaaa tatggcctgt gagatgtggg tttatannnn nnnnnnnnnn nnnnnnnnnn 1441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1501 nnnnnnnnnn nnnnnnaatt atattcaagt ttgagagact cttgtcaata aatcttttct 1561 tttttagttg aacaggtagt taagcccccc caaaacaaga cggaaagtga aaatacttca 1621 gataaaccca aaagaaagaa aaagggaggc aaaaatggaa aaaatagaag aaacagaaag 1681 aagaaaaatc catgtaatgc agaatttcaa aatttctgca ttcacggaga atgcaaatat 1741 atagagcacc tggaagcagt aacatgcagt aagttttcct aaagcatata gatttttgta 1801 tttctagcac catgtctgnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1861 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnca 1921 caccgcacgt gagtgtgatt ataattttta aatgtgaatt gcttgcagaa tgtcagcaag 1981 aatatttcgg tgaacggtgt ggggaaaagt ccatgaaaac tcacagcatg attgacagta 2041 gtttatcaaa aattgcatta gcagccatag ctgcctttat gtctgctgtg atcctcacag 2101 ctgttgctgt tattacagtc cagtaagtat gacataactt acaaattctt aataaaataa 2161 tgggaggtta atnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntatagatg 2281 aatagaacct tgataacatt agaatgcctt gttctctgaa ggcttagaag acaatacgtc 2341 aggaaatatg aaggagaagc tgaggaacga aagaaacttc gacaagagaa tggaaatgta 2401 catgctatag cataactgaa gataaaatta caggtttgag ttttaaaata tatctttaga 2461 tcatatccta taattttgaa aaatttaacn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2581 nnnnnnnnng taacattttg ttttatttta ttattttatt ttattttatt ttctcacagg 2641 atatcacatt ggagtcactg ccaagtcata gccataaatg atgagtcggt cctctttcca 2701 gtggatcata agacaatgga ccctttttgt tatgatggtt ttaaactttc aattgtcact 2761 ttttatgcta tttctgtata taaaggtgca cgaaggtaaa aagtattttt tcaagttgta 2821 aataatttat ttaatattta atggaagtgt atttatttta cagctcatta aactttttta 2881 accaaacaaa ttgagagttt gaatattagt tctgatattg caagactcca gtgtactttt 2941 ctc //