LOCUS       AH002699                1303 bp    DNA     linear   HUM 01-AUG-2016
DEFINITION  Homo sapiens follicle stimulating hormone beta-subunit (FSHB) gene,
            complete cds.
ACCESSION   AH002699 J04612 M24538 M24539 M24540 M24541
VERSION     AH002699.2
KEYWORDS    follicle-stimulating hormone beta-subunit; follitropin.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1303)
  AUTHORS   Keene,J.L., Matzuk,M.M., Otani,T., Fauser,B.C., Galway,A.B.,
            Hsueh,A.J. and Boime,I.
  TITLE     Expression of biologically active human follitropin in Chinese
            hamster ovary cells
  JOURNAL   J. Biol. Chem. 264 (9), 4769-4775 (1989)
   PUBMED   2494176
COMMENT     On or before Aug 1, 2016 this sequence version replaced M24538.1,
            M24539.1, M24540.1, M24541.1, AH002699.1.
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /map="11p13"
                     /cell_line="JAr"
                     /tissue_type="choriocarcinoma"
     gene            69..1296
                     /gene="FSHB"
     regulatory      69..75
                     /regulatory_class="TATA_box"
                     /gene="FSHB"
                     /note="G00-119-955"
     exon            101..163
                     /gene="FSHB"
                     /note="alternative exon; G00-119-955"
                     /number=1
     exon            134..163
                     /gene="FSHB"
                     /note="alternative exon; G00-119-955"
                     /number=1
     intron          order(161..>209,<310..328)
                     /gene="FSHB"
                     /note="0.7 kb gap; G00-119-955"
     gap             210..309
                     /estimated_length=unknown
     exon            329..493
                     /gene="FSHB"
                     /note="G00-119-955"
                     /number=2
     CDS             join(335..493,658..888)
                     /gene="FSHB"
                     /codon_start=1
                     /product="follicle stimulating hormone beta-subunit"
                     /protein_id="AAA52470.1"
                     /db_xref="GDB:G00-119-955"
                     /translation="MKTLQFFFLFCCWKAICCNSCELTNITIAIEKEECRFCISINTT
                     WCAGYCYTRDLVYKDPARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHC
                     GKCDSDSTDCTVRGLGPSYCSFGEMKE"
     intron          order(494..>505,<606..657)
                     /gene="FSHB"
                     /note="1.35 kb gap; G00-119-955"
                     /number=2
     gap             506..605
                     /estimated_length=unknown
     exon            658..1059
                     /gene="FSHB"
                     /note="G00-119-955"
                     /number=3
     regulatory      884..889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSHB"
                     /note="G00-119-955; putative"
     gap             1060..1159
                     /estimated_length=unknown
     exon            1160..1296
                     /gene="FSHB"
                     /note="G00-119-955"
     polyA_site      1296
                     /gene="FSHB"
BASE COUNT          286 a          237 c          223 g          257 t
ORIGIN      
        1 gcttcaggct agcattggtc atattaatac ccaacaaatc cacaaggtgt tagttgcaca
       61 tgattttgta taaaaggtga actgagattt cattcagtct acagctcttg ccaggcaagg
      121 cagccgacca caggtgagtc ttggcatcta ccgttttcaa gtgacagcta cttttgaaat
      181 tacagatttg tcaggacatg gaggacaaan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      301 nnnnnnnnnt tcattgtttg cttcccagac caggatgaag acactccagt ttttcttcct
      361 tttctgttgc tggaaagcaa tctgctgcaa tagctgtgag ctgaccaaca tcaccattgc
      421 aatagagaaa gaagaatgtc gtttctgcat aagcatcaac accacttggt gtgctggcta
      481 ctgctacacc agggtaggta ccatgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      601 nnnnnaaata ggaacttcca caataccata acctaactct cttcttaaac tcctcaggat
      661 ctggtgtata aggacccagc caggcccaaa atccagaaaa catgtacctt caaggaactg
      721 gtatacgaaa cagtgagagt gcccggctgt gctcaccatg cagattcctt gtatacatac
      781 ccagtggcca cccagtgtca ctgtggcaag tgtgacagcg acagcactga ttgtactgtg
      841 cgaggcctgg ggcccagcta ctgctccttt ggtgaaatga aagaataaag atcagtggac
      901 atttcaggcc acataccctt gtcctgaagg accaagatat tcaaaaagtc tgtgtgtgtg
      961 caatgtgccc aggggacaaa ccactggatc aggggattca gactctactg atccctggtc
     1021 tactggcaga gggaactctg ggaattgaga gtgctggggn nnnnnnnnnn nnnnnnnnnn
     1081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1141 nnnnnnnnnn nnnnnnnnna aattgtaatt tggggctgtg gaaattagcc tgcctctatt
     1201 cattacttaa acaaattgat cacatgctac taggctcctg caaactcctt tttgagataa
     1261 agggaaaaaa ccaaactatc tcaccctacc ctccctagga tcc
//