LOCUS       HUMG6PDA                2167 bp    mRNA    linear   HUM 08-NOV-1994
DEFINITION  Human glucose-6-phosphate dehydrogenase variant A-, complete cds.
ACCESSION   M21248 J03231
VERSION     M21248.1
KEYWORDS    dehydrogenase; glucose-6-phosphate dehydrogenase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2167)
  AUTHORS   Hirono,A. and Beutler,E.
  JOURNAL   Unpublished
REFERENCE   2  (bases 538 to 675)
  AUTHORS   Hirono,A. and Beutler,E.
  TITLE     Molecular cloning and nucleotide sequence of cDNA for human
            glucose-6-phosphate dehydrogenase variant A(-)
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (11), 3951-3954 (1988)
   PUBMED   2836867
COMMENT     Original source text: Human black male Epstein-Barr
            virus-transformed lymphoblastoid cells, cDNA to mRNA, clone A-19.
            Draft entry and computer readable copy of sequence [2] kindly
            provided by A.Hirono (13-MAY-1988).
FEATURES             Location/Qualifiers
     source          1..2167
                     /db_xref="H-InvDB:HIT000194779"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="Xq28"
     gene            1..2167
                     /gene="G6PD"
     CDS             15..1562
                     /gene="G6PD"
                     /note="glucose-6-phosphate dehydrogenase variant A- (EC
                     1.1.1.49)"
                     /codon_start=1
                     /protein_id="AAA52500.1"
                     /db_xref="GDB:G00-120-621"
                     /translation="MAEQVALSRTHVCGILREELFQGDAFHQSDTHIFIIMGASGDLA
                     KKKIYPTIWWLFRDGLLPENTFIMGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFF
                     ARNSYVAGQYDDAASYQRLNSHMDALHLGSQANRLFYLALPPTVYEAVTKNIHESCMS
                     QIGWNRIIVEKPFGRDLQSSDRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFAN
                     RIFGPIWNRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKP
                     ASTNSDDVRDEKVKVLKCISEVQANNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTT
                     ATFAAVVLYVENERWDGVPFILRCGKALNERKAEVRLQFHDVAGDIFHQQCKRNELVI
                     RVQPNEAVYTKMMTKKPGMFFNPEESELDLTYGNRYKNVKLPDAYERLILDVFCGSQM
                     HFVRSDELREAWRIFTPLLHQIELEKPKPIPYIYGSRGPTEADELMKRVGFQYEGTYK
                     WVNPHKL"
     variation       216
                     /gene="G6PD"
                     /note="a in G6PD(-); g in G6PD(+)"
     variation       390
                     /gene="G6PD"
                     /note="g in G6PD(-); a in G6PD(+)"
BASE COUNT          457 a          717 c          604 g          389 t
ORIGIN      17 bp upstream of NaqIII site; chromosome Xq28.
        1 gcgcagacag cgtcatggca gagcaggtgg ccctgagccg gacccacgtg tgcgggatcc
       61 tgcgggaaga gcttttccag ggcgatgcct tccatcagtc ggatacacac atattcatca
      121 tcatgggtgc atcgggtgac ctggccaaga agaagatcta ccccaccatc tggtggctgt
      181 tccgggatgg ccttctgccc gaaaacacct tcatcatggg ctatgcccgt tcccgcctca
      241 cagtggctga catccgcaaa cagagtgagc ccttcttcaa ggccacccca gaggagaagc
      301 tcaagctgga ggacttcttt gcccgcaact cctatgtggc tggccagtac gatgatgcag
      361 cctcctacca gcgcctcaac agccacatgg atgccctcca cctggggtca caggccaacc
      421 gcctcttcta cctggccttg cccccgaccg tctacgaggc cgtcaccaag aacattcacg
      481 agtcctgcat gagccagata ggctggaacc gcatcatcgt ggagaagccc ttcgggaggg
      541 acctgcagag ctctgaccgg ctgtccaacc acatctcctc cctgttccgt gaggaccaga
      601 tctaccgcat cgaccactac ctgggcaagg agatggtgca gaacctcatg gtgctgagat
      661 ttgccaacag gatcttcggc cccatctgga accgggacaa catcgcctgc gttatcctca
      721 ccttcaagga gccctttggc actgagggtc gcgggggcta tttcgatgaa tttgggatca
      781 tccgggacgt gatgcagaac cacctactgc agatgctgtg tctggtggcc atggagaagc
      841 ccgcctccac caactcagat gacgtccgtg atgagaaggt caaggtgttg aaatgcatct
      901 cagaggtgca ggccaacaat gtggtcctgg gccagtacgt ggggaacccc gatggagagg
      961 gcgaggccac caaagggtac ctggacgacc ccacggtgcc ccgcgggtcc accaccgcca
     1021 cttttgcagc cgtcgtcctc tatgtggaga atgagaggtg ggatggggtg cccttcatcc
     1081 tgcgctgcgg caaggccctg aacgagcgca aggccgaggt gaggctgcag ttccatgatg
     1141 tggccggcga catcttccac cagcagtgca agcgcaacga gctggtgatc cgcgtgcagc
     1201 ccaacgaggc cgtgtacacc aagatgatga ccaagaagcc gggcatgttc ttcaaccccg
     1261 aggagtcgga gctggacctg acctacggca acagatacaa gaacgtgaag ctccctgacg
     1321 cctacgagcg cctcatcctg gacgtcttct gcgggagcca gatgcacttc gtgcgcagcg
     1381 acgagctccg tgaggcctgg cgtattttca ccccactgct gcaccagatt gagctggaga
     1441 agcccaagcc catcccctat atttatggca gccgaggccc cacggaggca gacgagctga
     1501 tgaagagagt gggtttccag tatgagggca cctacaagtg ggtgaacccc cacaagctct
     1561 gagccctggg cacccacctc cacccccgcc acggccaccc tccttcccgc cgcccgaccc
     1621 cgagtcggga ggactccggg accattgacc tcagctgcac attcctggcc ccgggctctg
     1681 gccacctggc cgcccctcgc tgctgctact acccgagccc agctacattc ctcagctgcc
     1741 aagcactcga gaccatcttg gcccctccag accctgcctg agcctaggag cttgagtcac
     1801 ctcctccact cactccagcc caacagaagg aaggaggagg gcgcccattc gtctgtccca
     1861 gagcttattg gccactgggt ctcgctccga gtggggccag ggtgggaggg agggtcaggg
     1921 ggaggaaagg ggcgagcacc cacgtgagag aatctgcctg tggccttgcc cgccagcctc
     1981 agtgccactt gacattcctt gtcaccagca acatctcgag ccccctggat gtcccctgtc
     2041 ccaccaactc tgcactccat ggccaccccg tgccacccgt aggcagcctc tctgctataa
     2101 gaaaagcaga cgcagcagct gggacccctc ccaacctcaa tgccctgcca ttaaatccgc
     2161 aaacagc
//