LOCUS       HUMFUMA                 1447 bp    mRNA    linear   HUM 08-NOV-1994
DEFINITION  Human mitochondrial fumarase mRNA, complete cds.
ACCESSION   M15502
VERSION     M15502.1
KEYWORDS    fumarase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1447)
  AUTHORS   Kinsella,B.T. and Doonan,S.
  TITLE     Nucleotide sequence of a cDNA coding for mitochondrial fumarase
            from human liver
  JOURNAL   Biosci. Rep. 6 (10), 921-929 (1986)
   PUBMED   3828494
COMMENT     Original source text: Human liver, cDNA to mRNA, clone pUC18.
FEATURES             Location/Qualifiers
     source          1..1447
                     /db_xref="H-InvDB:HIT000194400"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="1q42.1"
     gene            1..1447
                     /gene="FH"
     mRNA            <1..1447
                     /gene="FH"
                     /note="fumarase mRNA; G00-119-133"
     CDS             1..1407
                     /gene="FH"
                     /note="fumarase precursor (EC 4.2.1.2)"
                     /codon_start=1
                     /protein_id="AAA52483.1"
                     /db_xref="GDB:G00-119-133"
                     /translation="MASQNSFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTER
                     MPTPVIKAFGILKRAAAEVNQDYGLDPKIANAIMKAADEVAEGKLNDHFPLVVWQTGS
                     GTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEV
                     HEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTR
                     IKAAMPRIYELARGGTAVGTGLNTRIGFAEKLAAKVAALTGLPFVTAPNKFEALAAHD
                     ALVELSGAMNTSSCSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQC
                     EAAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENC
                     VVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYL
                     TAEQFDEWVKPKDMLGPK"
     mat_peptide     4..1404
                     /gene="FH"
                     /product="fumarase; G00-119-133"
BASE COUNT          456 a          274 c          344 g          373 t
ORIGIN      871 bp upstream of PstI site.
        1 atggcaagcc aaaattcctt ccggatagaa tatgatacct ttggtgaact aaaggtgcca
       61 aatgataagt attatggcgc ccagaccgtg agatctacga tgaactttaa gattggaggt
      121 gtgacagaac ggatgccaac cccagttatt aaagcttttg gcatcttgaa gcgagcggcc
      181 gctgaagtaa accaggatta tggtcttgat ccaaagattg ctaatgcaat aatgaaggca
      241 gcagatgagg tagctgaagg taaattaaat gatcattttc ctctcgtggt atggcagact
      301 ggatcaggaa ctcagacaaa tatgaatgta aatgaagtca ttagcaatag agcaattgaa
      361 atgttaggag gtgaacttgg cagcaagata cctgtgcatc ccaacgatca tgttaataaa
      421 agccagagct caaatgatac ttttcccaca gcaatgcaca ttgctgctgc aatagaagtt
      481 catgaagtac tgttaccagg actacagaag ttacatgatg ctcttgatgc aaaatccaaa
      541 gagtttgcac agatcatcaa gattggacgt actcatactc aggatgctgt tccacttact
      601 cttgggcagg aatttagtgg ttatgttcaa caagtaaaat atgcaatgac aagaataaaa
      661 gctgccatgc caagaatcta tgagctcgca cgtggaggca ctgctgttgg tacaggttta
      721 aatactagaa ttggctttgc agaaaagctt gctgcaaaag tggctgcact tacaggcttg
      781 ccttttgtca ctgctccgaa taaatttgaa gctctggctg ctcatgacgc tctggttgag
      841 ctcagtggag ccatgaatac tagctcctgc agtctgatga agatagcaaa tgatattcga
      901 tttttgggtt ctggtcctcg gtcaggtctg ggagaattga tcttgcctga aaatgaacca
      961 ggaagcagta tcatgccagg caaggtgaac cctactcagt gtgaagctgc aatgaccatg
     1021 gttgcagccc aagtcatggg gaaccatgtt gctgtcactg tcggaggcag caatggacat
     1081 tttgagttga atgttttcaa gccaatgatg attaaaaatg tgttacactc agccaggctg
     1141 ctgggggatg cttcagtttc ctttacagaa aactgcgtgg tgggaatcca ggccaataca
     1201 gaaaggatca acaagctgat gaatgagtct ctaatgttgg tgacagctct caatcctcat
     1261 atagggtatg acaaggcagc aaagattgct aagacagcac acaaaaatgg atcaacctta
     1321 aaggaaactg ctatcgaact tggctatctc acagcagagc agtttgacga atgggtaaaa
     1381 cctaaggaca tgctgggtcc aaagtgattt acaaaattta taatgaaaat aaacatgtat
     1441 aaaattt
//