LOCUS LQHI01000003 13866 bp DNA linear BCT 14-JAN-2016 DEFINITION Hadesarchaea archaeon DG-33 contig16455, whole genome shotgun sequence. ACCESSION LQHI01000003 LQHI01000000 VERSION LQHI01000003.1 DBLINK BioProject: PRJNA270657 BioSample: SAMN04385803 KEYWORDS WGS. SOURCE Hadesarchaea archaeon DG-33 (sediment metagenome) ORGANISM Hadesarchaea archaeon DG-33 Archaea; Euryarchaeota; Hadesarchaea. REFERENCE 1 (bases 1 to 13866) AUTHORS Baker,B.J., Saw,J.H., Lind,A.E., Lazar,C.S., Hinrichs,K.U., Teske,A.P. and Ettema,T.J. TITLE Genomic inference of the metabolism of cosmopolitan subsurface Archaea, Hadesarchaea JOURNAL Nat Microbiol 1, 16002 (2016) PUBMED 27572167 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 13866) AUTHORS Baker,B.J., Saw,J.H., Lind,A.E., Lazar,C.S., Hinrichs,K.-U., Teske,A.P. and Ettema,T.J. TITLE Direct Submission JOURNAL Submitted (29-DEC-2015) Marine Sciences, Univ of Texas Austin, 750 Channel View Dr., Port Aransas, TX 78373, USA COMMENT Annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (released 2013). Information about the Pipeline can be found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/ ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Date :: 01/05/2016 17:49:22 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline Annotation Method :: Best-placed reference protein set; GeneMarkS+ Annotation Software revision :: 3.0 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region Genes :: 950 CDS :: 862 Pseudo Genes :: 63 rRNAs :: 1 (16S) partial rRNAs :: 1 (16S) tRNAs :: 23 ncRNAs :: 1 ##Genome-Annotation-Data-END## ##Genome-Assembly-Data-START## Assembly Method :: IDBA-UD v. 1.0.9 Assembly Name :: DG-33 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 4.0x Sequencing Technology :: Illumina HiSeq ##Genome-Assembly-Data-END## FEATURES Location/Qualifiers source 1..13866 /organism="Hadesarchaea archaeon DG-33" /mol_type="genomic DNA" /isolate="DG-33" /isolation_source="Methane-rich estuary sediments 52-54 cm" /db_xref="taxon:1775754" /environmental_sample /geo_loc_name="USA: White Oak River Estuary, North Carolina" /lat_lon="34.7414 N 77.1234 W" /collection_date="Oct-2010" /note="metagenomic; derived from metagenome: sediment metagenome" gene complement(<1..387) /locus_tag="AVW05_00465" CDS complement(<1..387) /locus_tag="AVW05_00465" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_013413983.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="KUO42045.1" /db_xref="GI:974127476" /translation="MASEQRKRPSARLSELPANEVEELVVKLAKEGVPPSRIGIIMRD QHAVPSVEGATGKGLQQILDAHGLKPEIPEDLMNKIRKAVPLYGHLARNPKDFGTKRA LEVVEAEIQKLAKYYKRKGSLASDWRY" gene complement(392..964) /locus_tag="AVW05_00470" CDS complement(392..964) /locus_tag="AVW05_00470" /inference="EXISTENCE: similar to AA sequence:SwissProt:Q8TV07.1" /note="HAM1-like protein;i t is suspected that this protein functions to remove nonstandard bases such as xanthine or inosine; Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="non-canonical purine NTP pyrophosphatase" /protein_id="KUO42046.1" /db_xref="GI:974127477" /translation="MALIFVTSNRHKFEEVSEIALKHGVELEHSDTPYIEIQADELEQ VVRPSVQQACALLRQPCFAEDAGLFVRALRGFPGPYSNFVFRTLGNEGLLKLMSGERD RRAEFRSAVGYCEPGEKPEVFTGKVEGTIALETRGTRGFGFDPVFVASEGDGRTFAEM PMNEKNRFSHRARAIEAFFKWYKQREKVRG" gene complement(955..1623) /locus_tag="AVW05_00475" CDS complement(955..1623) /locus_tag="AVW05_00475" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_004068534.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="O-sialoglycoprotein endopeptidase" /protein_id="KUO42047.1" /db_xref="GI:974127478" /translation="MVLFKKGAEANLYLENFSRVLYRAGKDRVIVKHRISKRYRVTEL DKQLRESRTALEAKLLADAKKAGTPTPTIFEVDRVDMRIVMGVIKGEQVKLVLDKLES SARQRLCKLIGKQVAKLHRAGIVHGDLTTSNMILTREGKVYFVDFGLGEYNPSLEARG VDLHLLRRALQSIHFRITDEAYRAVLSGYKREFGEGANEVIKRVEEIERRGRYVQKEE RAWH" gene 1802..2110 /locus_tag="AVW05_00480" CDS 1802..2110 /locus_tag="AVW05_00480" /inference="EXISTENCE: similar to AA sequence:SwissProt:Q8PTU2.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="KUO42048.1" /db_xref="GI:974127479" /translation="MRRKRRYIAFEFMGEASKREISWAINHVLHARKMEVDKTMLKLV LYDTDSRRGLLRCGHKQVNEVKAAMLSIKKIGGKEASFVILGVSGTVKAAKRKFLAPA " gene 2180..2932 /locus_tag="AVW05_00485" CDS 2180..2932 /locus_tag="AVW05_00485" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_013683723.1" /note="cleaves peptide bonds; Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="proteasome subunit alpha" /protein_id="KUO42049.1" /db_xref="GI:974127480" /translation="MAFVPPGAGYDRAITIFSPDGKLFQVQYAQEAVKRGLTALGIKV NEGVVLAAEKRVRSKLVEEVSIEKIFQVDEHIGAAASGLIADARVLIDHARIEAQINR LRYDEPISVQALAKRIGDIKQLYTQHGGVRPFGARLLIAGVDMKSAHLFETDPSGVVA AYKCQAIGGGASTVTDFLERRYEEKMSLKDVVILALEALRTVIEEELDPDKVEMAIIP SKTKRFEKLGSEDLAKYIKQMSPKPPAKPAKE" gene 2939..3631 /locus_tag="AVW05_00490" CDS 2939..3631 /locus_tag="AVW05_00490" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_013799100.1" /note="Shwachman#Bodian#Diamond syndrome protein family; SBDS; similar to eukaryotic proteins involved in RNA metabolism or binding; Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="RNA-associated protein" /protein_id="KUO42050.1" /db_xref="GI:974127481" /translation="MVRLEDAVIAKMSSHDTAFEVLVDPELALALRTGEEVDIHSMLA IDKIFKDSKKGEAASEEMMQKVFGTLDVFKIAEQVIRKGEVQVTTEQRRKMREQRWRQ VVALISKRAINPQTGLPHPPARIEGALVEARVHVDEFKSAEEQLPGIVKVLLPIIPLK FETRRIAIKIPASYTGKANRVVRNFATVKQEQWLNDGSWAVVVEIPAGIQGEFFDKLN NMTRGEVETKVL" gene 3632..4327 /locus_tag="AVW05_00495" CDS 3632..4327 /locus_tag="AVW05_00495" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_014734539.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="KUO42051.1" /db_xref="GI:974127482" /translation="MLHVQNRELVVPGQLIAEGDYRVYEGAFREDKQIYASVVGLADV RGQDIRIIPLQGGYIPKQGDVVIGVVVDSHYSGWILDINSPYTGNLFVSDLLRRKVDL VREDISQYLSMRDVVIAGVKDVNERMRVQLEAGEPGMGRVEGGKLVEISPMKIPRVIG RKGSMLKTLQNVGQCRIEVGQNGRIMIWGKNPRMTNAIIEAVLMIEREAHTSGLTDRV HLMLEKIKSEGGE" gene 4328..5050 /locus_tag="AVW05_00500" CDS 4328..5050 /locus_tag="AVW05_00500" /inference="EXISTENCE: similar to AA sequence:SwissProt:Q8TYC1.1" /note="involved in the 3' to 5' degradation of a variety of RNA species; forms a trimer of heterodimers (hexamer) with Rrp42; Rrp41 is the catalytically active subunit; Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="exonuclease" /protein_id="KUO42052.1" /db_xref="GI:974127483" /translation="MEKPEKLIVDGKRLDGRAPDELRQLKIEAGVLERADGSAYVELG ANKVLAAVYGPREMHPRHHQQPDMAVLRCRYNMAPFSVDERKRPGPDRRSVEISKVTR EALEPVVFLELYPRSVIDVFIEVLQAEAGTRTAGINAAAVALADAGIPMRDMVSSVAV GKVDGTIVLDPAKDEDQWGTTDMPIAMIPRKKLITLLQMDGHFTGEEFKQALDLAFKG CEQIYEAQRRTLMEKYAIKQGE" gene 5054..5824 /locus_tag="AVW05_00505" CDS 5054..5824 /locus_tag="AVW05_00505" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_014405464.1" /note="involved in the 3' to 5' degradation of a variety of RNA species; forms a trimer of heterodimers (hexamer) with Rrp42; Rrp41 is the catalytically active subunit; Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="KUO42053.1" /db_xref="GI:974127484" /translation="MDMYGIVSSVKRDYIVDLVRQGKRVDTRMLDQFREVSVEVSPIK SAQGSALVKVGKTQVLAGVKLEHAEPFSDRPDSGVLIVNAELLPLASPTFEPGRPDEN AIELARVVDRGIRESEAIDLEKLVIKSGEDVWAVFIDIYALDHDGNLIDASALAAIAA LLNVKLPEDEAWTLSEFPLQKKPVAVTVAKINGKLMVDPCLDEESVMDARITMATIED GSICAMQKGGIGHFSREELEQAYELARVKAAELRAKLG" gene 5829..6095 /gene="rpl37ae" /locus_tag="AVW05_00510" CDS 5829..6095 /gene="rpl37ae" /locus_tag="AVW05_00510" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_004066570.1" /note="structural models have indicated that the folded zinc-finger motif interacts mainly with domain III of 23S rRNA, whereas the amino-terminal region of L37 interacts primarily with domain II; Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="50S ribosomal protein L37" /protein_id="KUO42054.1" /db_xref="GI:974127485" /translation="MPRTKKIGSAGKFGPRYGTKIRKLALAVDKKLQQRYKCPSCGAV KVKRIGTSIWQCGRCGVKFAGAAYSLSALAPPAEMKASGGVEES" gene 6316..6762 /locus_tag="AVW05_00515" CDS 6316..6762 /locus_tag="AVW05_00515" /inference="COORDINATES: ab initio prediction:GeneMarkS+" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS+." /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="KUO42055.1" /db_xref="GI:974127486" /translation="MCRVGRKTINKLASLAGSLGHNRVMIVSSLGXRPIELRFLAVTN GWRWLDVWVELGEIKLQRDLGQKVKLEXVRXYAEGQXAQNLANFLGELLGLPXSSELP NTGAVVVITSDNQLKLQXQLRPSSEAVGPVLQITSFGXSXGKGETS" gene 6740..7000 /locus_tag="AVW05_00520" CDS 6740..7000 /locus_tag="AVW05_00520" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_004030798.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="KUO42056.1" /db_xref="GI:974127487" /translation="MVKAKQASATVEFTFRTARXAGAVQQALXPEEAXPASTRCRTSI RRRKNVLCXRVDAEDTAALRAALNSFLRWAIVARDMIEXRRK" gene 7001..7366 /locus_tag="AVW05_00525" CDS 7001..7366 /locus_tag="AVW05_00525" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_013413907.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="prefoldin subunit beta" /protein_id="KUO42057.1" /db_xref="GI:974127488" /translation="MXKLSPQLRHQLAQFQQAQQQAQALXXQKQQLXLLMRETERALE ELDKLQEGAAVYKXVGTILVKSXREELKKSLSEQXETLDXXIKTLXRQXERVVQRLRE MREKLEGAXKGKQLGEEAA" gene 7381..8364 /locus_tag="AVW05_00530" CDS 7381..8364 /locus_tag="AVW05_00530" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_015859106.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="KUO42058.1" /db_xref="GI:974127489" /translation="MKELANFLAEAARRGQRILVLCHHNADPDAATSAIVLAEALKHL GAQAQAGASEDISLIAQNVLKTFGREIMINPPLDVDLAVLVDTSSLEHLGKLGEQLRK GLPKLVVIDHHRPVEAMKQLTTLYFVREEFTSEAEIILRLIKELGVKLTSEQASLLLA GIISDTGHFRFAKDETFEAVHQLLEAGGDYARVNESLNLSEDYSKRIAMLKAAARSKL CRIHKRLVAFSELGSFEGDAAGMLVRIGADVAFVGSEEKGEVRVSGRARQKTLKLTGL HLGELMEEMGKQFEGSGGGHAGAASMHGKGKLEEVKKHLFGFLQRKLKSKK" gene 8375..9304 /locus_tag="AVW05_00535" CDS 8375..9304 /locus_tag="AVW05_00535" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_010876670.1" /note="TYW1; converts position 37 of tRNA anticodon to wybutosine; Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="wyosine biosynthesis protein TYW1" /protein_id="KUO42059.1" /db_xref="GI:974127490" /translation="MAVSADELSELELAGYRFVGEHKHSAVKVCHWTRKSLLNRGVCY KERFYGRDLGIRSHRCLQLAPSLPFCDHRCVYCWRNTDVTTPSWVGEVDEPADILDGA ISAQRKLLSGFGGNPNADKKKFKEAQEPKHCAISLAGEPTFYPNLSELIEECGRRGMT SFLVTNGMHPEVLEHIAEPTQLYISVVAPDPETYEVVCQPTVPDGWKRLNKSLELMSC FKCRKAIRLTLVKGLNLKKPEEYAKIIEKAGADFIEAKAYMFVGFSRRRLVMENMPLS DEVNGFARELARETGYSIAGESRPSRVVLLKKA" gene complement(9347..10474) /locus_tag="AVW05_00540" CDS complement(9347..10474) /locus_tag="AVW05_00540" /inference="COORDINATES: ab initio prediction:GeneMarkS+" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS+." /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="KUO42060.1" /db_xref="GI:974127491" /translation="MKKRRKKMFGTEQRGVAAITAIVIVAASIGAGVATPVIVDAVDV DPDSPFYGLERLGEQIRMVGGEDQMKERWGEYVSLVNRGKGLAHKSILEEFVEKMRYV VPGDVETKREIVQWMQEQMPEIGMVQLRLCKELCQQLRQELENTPEAEWFENCIRECE NFEENWDKLELRAQIRARLRLIREITENIANRYRAQIHKPMDVDVYFDIDNVLVDVDI TVNVEVDISAENLPDLSEAFENKLEEFDNLLAEVQIMLEGAPENAHGKHAAERLVEVA IGLKDKAVAAYEEGKIRRALALIHAAKIHLGNAERILENAEEWEPEFATQWYTWRNRW ENMKQEWTGEGIWENIIENYNRYAETVRKRWEEEKHKGPAW" gene 10739..11167 /locus_tag="AVW05_00545" CDS 10739..11167 /locus_tag="AVW05_00545" /inference="COORDINATES: ab initio prediction:GeneMarkS+" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS+." /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="KUO42061.1" /db_xref="GI:974127492" /translation="MTIREAFGIVALVVILQLCLGALIYVITPTPGLDLYSIVIAIAV MVAVAGSIAAVLVFFFKRYASERTLRVALMALTPDERLVFEAILRAGEARQDKLRREL DMSKSKLSALVNNLERKHAITKTRYFKTNILRVSKEFSGR" gene 11282..11899 /locus_tag="AVW05_00550" CDS 11282..11899 /locus_tag="AVW05_00550" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_014587127.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="KUO42062.1" /db_xref="GI:974127493" /translation="MKEMLERMRKHFDAQEKLRERVLDASREVIRFSARAIAATHREN QSSADEFLAKARDTLATLAEAVKAEPHLANSGIILAAYQEYGEATLVRALIRDGKLLT PEELSIPYKSYLAALADTVGELRRHVLDLIRADEVERAEQALKLMEEIFELLMEFDYP DAILPGMKRKQDMVRRVIEHTRGDLPSGSESLNVLLSGPSEGSSE" gene 11896..13479 /locus_tag="AVW05_00555" CDS 11896..13479 /locus_tag="AVW05_00555" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_013413423.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="KUO42063.1" /db_xref="GI:974127494" /translation="MTKFNIRKLRASAKKDYESAWLESAKLVEKRGKLFSLKDKTKTH PLFELIERARRVLLELGFAETVLPMIVDKKEVYAQYGPEAPVILDRVFFLAGLERPDI GISQKKIQEIRELVPDFKEIEKLQGIFRRYKRGEIVADDLVEVMVKELDIREEQATGL LALFGELRELKPVPMDLTLRSHTTAGWFLVLRELQRRESLPLQLFSIGPKFRREQRLD PTHLYESWTASMVIAAEKISLEDGERITRKILDKLGFSEVKFSIKTATSKYYAPQMEF EIFVKHPKTGEFIEVGDAGFYSPVALSHYDIAFPVFNLGIGLERVLMIETGGTDIRVL MYPYLYKAAEFSDRELADMIKCEREPGTEIGRAIAAAIVKAAQQHADEPSPCDFKAFE GKLGGKRVIVRVVEPERGTKLIGPAGFNEIYVYEGNVVGVPPKGWEKDEFLNSVREKG VSTGISYIIAFAALAAQEIERAAKSGKKQVKVRVRAAKLPSDINLVIDEAAQRYITAN KKRIDVRGPVFTTVVAEFG" gene complement(13480..13866) /locus_tag="AVW05_00560" /pseudo CDS complement(13480..13866) /locus_tag="AVW05_00560" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_012582460.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 BASE COUNT 3355 a 3416 c 3901 g 3155 t ORIGIN 1 gtatcgccag tcagaagcca aactcccttt tctcttgtag tacttggcca acttctgaat 61 ctcggcctca accacctcca gagcgcgctt ggtcccgaaa tccttcgggt tgcgggcgag 121 gtggccgtag aggggcaccg cttttcgaat tttattcatg agatcctcag gtatctcggg 181 tttcaggccg tgggcatcga gtatttgctg caaacccttt cccgtcgccc cctcaacact 241 cggcacggca tgctggtcac gcatgattat gcctatcctg ctcggaggga caccctcctt 301 cgctagcttc accacgagct cttcaacttc gttggctggt agctcactca gccttgcgct 361 tggacgtttc ctttgctcgc ttgccattcg ttcacccacg gactttctct ctttgtttat 421 accacttgaa aaatgcttcg attgcgcgag ctcggtgaga aaaacggttt ttctcgttca 481 ttggcatttc agcgaaagtc ctgccatcgc cctcgctggc cacgaagacg gggtcaaatc 541 caaagccacg cgtgccacga gtttcgagcg cgattgtgcc ctcaactttg cctgtgaaga 601 cctcgggttt ctcaccaggc tcgcagtacc cgacggcaga cctgaactcg gctcgtcggt 661 ccctttcccc gctcataagc ttcagcaagc cctcgttgcc caaggtccgg aaaacgaaat 721 tggagtaggg tcccgggaaa cctcgaagcg ctcgaacgaa taatccagca tcctcggcga 781 agcagggttg tctgagcaag gcgcatgctt gctggacgct cgggcgcaca acttgctcga 841 gttcgtccgc ttgaatctct atgtagggtg tgtcactgtg ctcgagctca actccgtgct 901 tcagcgcgat ttcactcacc tcctcgaact tgtggcggtt actggtcacg aagattagtg 961 ccatgcgcgt tcctcctttt ggacatagcg cccacgacgc tcaatttctt caactcgttt 1021 gatcacttcg tttgccccct cgccgaattc tcgcttgtag ccagataaaa ccgcgcggta 1081 agcctcgtcg gtaatacgaa aatggatact ttgaagggcg cgcctgagca agtgtagatc 1141 cactccgcga gcttcaagcg agggattgta ttcacccagc ccaaagtcga cgaaatagac 1201 tttgccttcc ctggtcagaa tcatattcga cgtcgtcagg tcaccgtgca cgatgccggc 1261 gcggtgcaac ttggcgactt gtttgcctat taacttgcat aacctctgcc tcgcggaaga 1321 ttccagcttg tcgagcacca acttgacctg ctcgcctttg atgaccccca tcacgatccg 1381 catgtctacg cgatcgacct caaatatcgt gggggtgggc gtccctgctt tttttgcatc 1441 tgcgagcaac tttgcttcga gcgcggttct agactcgcgc aactgtttat ccaattcagt 1501 cacgcggtaa cgcttcgaga tgcggtgctt aacgatgacc ctgtctttac ctgcgcggta 1561 gagcacgcgt gagaagttct cgaggtagag atttgcctca gctccttttt taaataacac 1621 catatcccac cacctaccac cgctattgac ttacatttat aacctaaatg aaatcaccct 1681 ttgcgataga ggtggctacc aagtctgacc tgccgccgtc taggttttcg gtaggggtgg 1741 ttttaaggag gaaaatacag ttcgttatta acattggtcg tcaactgata gtgggagaaa 1801 agtgaggcgg aagcgcaggt acatcgcgtt cgagttcatg ggcgaggcaa gcaagaggga 1861 aatctcgtgg gcaattaatc acgttttaca tgcccgcaaa atggaggtcg acaaaacgat 1921 gctgaagctc gtactttacg acacggactc gcgacgaggc ctgctgcgct gcggtcataa 1981 gcaggtcaac gaggtcaagg cagcgatgtt gagcattaag aaaatcggcg gcaaagaagc 2041 atcgttcgtg attttgggcg tttccggcac ggtaaaggca gcgaagagga agttcttagc 2101 acccgcttaa acaaagtatt aataaatgct cttgcttaga agatacagtc acgatcatca 2161 ataaacaagg tgtaaatgta tggcttttgt gccacctgga gccggctacg atagggcgat 2221 taccatcttc agcccagatg gtaaactatt ccaggttcag tacgcccaag aggctgtgaa 2281 gcggggcctg acagccttgg gcatcaaggt aaacgaagga gtggttttgg ctgcggaaaa 2341 aagagttcgg agcaaactag tggaagaagt gtcaatagag aagatattcc aagtggacga 2401 gcatatcgga gctgcagctt ctgggctaat cgctgacgct cgcgtgctga tcgatcacgc 2461 gcgcatcgag gcgcagatta accggttgcg ctacgatgag ccgattagcg tgcaggcgct 2521 ggcgaagcgc ataggcgata tcaagcagct ctacacccaa catggcggcg tcagaccttt 2581 tggggctagg ctgctaattg ctggcgtcga catgaagagc gctcacctct tcgaaaccga 2641 tcccagtggt gtggttgcag cgtacaagtg ccaagcaatc ggaggcggag cctcaacggt 2701 cacggatttc ctcgagcgcc gctatgaaga gaagatgtcg ctcaaagacg tagttatcct 2761 cgctctagag gcgctgcgaa ctgtaatcga ggaggaactt gacccagaca aagtagagat 2821 ggcaatcatc ccgagcaaga ctaagcgttt cgagaagttg ggttccgaag atttggctaa 2881 atacataaaa caaatgagtc ccaagccgcc agccaagccc gccaaggagt agcgggttat 2941 ggtaaggctt gaagatgcag tcatcgctaa gatgtctagc catgacacgg cttttgaagt 3001 acttgtcgat cctgagttag ccctcgctct aagaacggga gaagaggtag acatccatag 3061 tatgctcgcc atagacaaaa ttttcaagga ctccaagaaa ggcgaggcgg catctgagga 3121 aatgatgcag aaggtcttcg gcacgctcga tgtgtttaaa atcgctgaac aggtgatccg 3181 aaagggcgag gtccaagtga ccaccgagca gcgccgcaag atgcgcgagc aacggtggcg 3241 acaggtcgtg gcgctcatct cgaagcgggc gataaacccc cagacgggcc ttcctcatcc 3301 acccgcgcga atcgagggcg cactagttga ggcaagggta catgtcgacg aattcaagag 3361 cgccgaggaa caactccccg gtatcgtaaa ggtattgctg ccaattatcc ccctaaagtt 3421 cgagacgcga agaatcgcga tcaaaattcc cgcaagctac actggcaagg ccaaccgagt 3481 ggtaagaaac ttcgccaccg tcaagcagga acagtggtta aatgatggtt cttgggccgt 3541 ggtcgtggag atacccgccg gcatccaagg ggagttcttc gacaagctta acaatatgac 3601 ccggggcgag gtcgaaacga aggtgttgta aatgcttcac gttcaaaatc gcgagctggt 3661 agtgcccggg cagctgatcg ccgagggaga ctaccgggtg tacgaaggcg cgtttcggga 3721 ggacaagcag atctacgcgt cggtcgtggg tctcgcggac gtgcgtgggc aagatatccg 3781 aatcatccca ctgcagggag gctacatccc gaagcaaggc gatgtggtga taggggtggt 3841 tgtagattcc cactactcgg gatggattct cgacataaac tcaccttata ctggaaatct 3901 ttttgtttca gatttgctgc ggcgaaaggt cgacctagtc cgcgaggata tcagccaata 3961 cttaagtatg cgagatgtgg tgatcgcggg ggtcaaagat gtgaacgagc gcatgcgggt 4021 tcagcttgag gcgggcgaac ccgggatggg tcgggttgag gggggaaaac tggttgagat 4081 ttcacctatg aaaatccccc gcgttatcgg acgaaagggc tcgatgctca aaacccttca 4141 gaatgttggt cagtgcagga tcgaggtcgg acagaacggg cggataatga tttggggaaa 4201 gaacccgcgt atgaccaacg ccatcatcga ggccgtactc atgatcgagc gcgaggcgca 4261 tacttctgga ttgaccgata gggtgcacct catgcttgaa aaaataaaat cagaaggagg 4321 agaatgaatg gaaaaacctg aaaaactcat tgtggacggc aaacggcttg atggtcgcgc 4381 gccggatgag ttaaggcagt tgaaaataga ggcgggcgtt ttggaacgag cagacggttc 4441 ggcctatgtc gagcttggtg ctaacaaggt gctcgcggca gtctacgggc cgcgggagat 4501 gcatccacgc caccatcagc agcctgatat ggcggtactg cgatgccgct acaacatggc 4561 cccattctcg gtggatgagc gaaagcgtcc cgggccagat aggcgctcgg tggagatatc 4621 taaggtgaca cgagaggccc ttgagccagt tgttttcttg gaactatacc cgagatcggt 4681 catcgatgtt ttcatcgagg ttctgcaggc cgaggctggg acgcgcaccg cgggcataaa 4741 cgctgcagcc gttgcactgg ctgatgctgg aattccgatg cgcgacatgg tctcatcggt 4801 cgcggtcggg aaggtagacg gtacaatagt tcttgacccg gccaaggatg aggaccagtg 4861 gggaacgacg gacatgccga tagccatgat ccctaggaag aagttgatta cactactgca 4921 gatggacggc cactttaccg gggaagagtt caagcaggct ctggatctcg catttaaggg 4981 gtgcgagcag atatacgaag cacagcggcg aaccctaatg gagaagtacg caatcaaaca 5041 gggggaataa aacatggaca tgtacgggat agtttcgagc gtcaagcgcg attacatcgt 5101 cgacctcgtg cgccaaggca agcgtgttga cacccggatg ttggaccagt tccgggaggt 5161 atcggttgag gtcagcccga tcaagagtgc tcaaggctca gctctcgtga aggttgggaa 5221 gacgcaggtg cttgctggcg tcaagttgga gcacgctgag ccgttttccg atcggcctga 5281 tagcggggtg ctgattgtca acgctgagct cttgccttta gcatcgccca ccttcgagcc 5341 ggggcgcccc gatgaaaatg caatcgagtt agctcgcgtg gtcgatcggg gcatacgtga 5401 gtcggaggca atcgatttag aaaagctggt aataaaatct ggcgaggatg tgtgggcagt 5461 attcatcgac atttacgccc tcgaccacga cggaaacctg atcgatgcat ccgcgctcgc 5521 ggcgatagcg gcgctcctga atgtaaagct gcccgaggac gaggcgtgga cgctgtccga 5581 gtttccgctc cagaaaaagc ccgtggcggt gaccgtggcg aaaatcaacg gcaagctgat 5641 ggttgacccg tgtctggacg aggaaagtgt gatggacgcg cgaataacca tggcgacgat 5701 tgaggacggc agcatatgtg cgatgcagaa gggcggcata gggcacttct cgcgggagga 5761 gctagagcag gcctacgagc tggcccgggt gaaggcagca gaacttcgag caaaattggg 5821 gtgaacgtgt gcctcgtacg aagaagatcg gttccgcggg caagttcggt ccgcgctatg 5881 gaacaaagat tcgaaagctc gccctagcgg tggataaaaa gctccaacag cgctacaaat 5941 gtccgagttg cggggcggta aaggttaaac gcattggtac ttcgatctgg cagtgcggac 6001 gttgtggagt gaagtttgct ggcgcggcat actcactctc agctctggcg ccccctgccg 6061 aaatgaaagc ctctggcgga gtggaggaga gttaagtgtt gaagtgcagc gactgcggaa 6121 cggtaattga gaagctcccc gaagggcgcg tgcgatgtcc tcactgtggg tcccgcatgc 6181 tgtaacaaac ctcgccgaag aggttgtccg taaaaatcaa ggcgaggtaa atgntcatct 6241 ccacttcgag gagaccaaca caccgtacga gaattttatg ccgggaactc gcgcgagttt 6301 tcccagatgc nacatatgtg ccgcgtgggg cgaaaaacaa taaacaaact agcctcactt 6361 gcaggctcac tcggtcacaa tcgtgtgatg attgtaagca gtctcggtga ncgaccaata 6421 gaattacgat ttttggccgt gaccaatggc tggcgatggc ttgacgtgtg ggtcgagcta 6481 ggtgagatca agctccagcg agatctcggg cagaaggtca agctagagag ngtgaggntt 6541 tatgccgaag gacaaaangc gcagaatctt gcaaattttc ttggtgagtt attgggccta 6601 cccatntcaa gtgaactgcc aaataccggn gcggttgtng tgataacttc cgacaaccag 6661 cttaagctcc agttncagct aagaccgagc tccgaggcag tngggccggt gctccaaatc 6721 acgagtttcg ggngatcana tggtaaaggc gaaacaagct agcgcaacgg tcgagttcac 6781 cttccgaacc gcgcgcgang caggngcagt acaacaggcg ctcaancccg aggaagcgtt 6841 nccagcttcg acgcgatgta ggacgagcat ccgacgcagg aaaaacgttt tatgcntgcg 6901 ggtagatgca gaagatacag cagccttgcg tgcggcgtta aattcgttcc ttcgatgggc 6961 aatcgtcgcg cgngatatga tcgaacngag gagaaaataa atgganaagc tatcaccnca 7021 gctgcgccat cagctcgcgc agttccagca ggctcagcag caggctcagg cgttgntgnc 7081 acagaagcaa cagctcganc tgctcatgcg ggaaacngag cgggcccttg aggaactcga 7141 taaactccaa gagggtgccg cagtctacaa gancgtngga acnatcttag tcaaatcaga 7201 ncgggaagaa cttaaaaaaa gtttgagcga gcagaangag acnctcgacn tgngaatcaa 7261 aacactcgng cgccaggang aacgngtcgt ncagcgcctg cgcgaaatgc gcgagaagct 7321 cgagggggcg ntcaagggta agcagcttgg cgaagaagcg gcatagctcg agctgaaatc 7381 atgaaagagc tagctaactt tttagcggaa gctgctaggc gcggacagcg aattttagtg 7441 ctttgccacc acaacgccga cccagacgcc gccaccagtg caatagtgct tgctgaagcg 7501 ctcaagcact tgggcgcgca ggctcaggct ggggcttcag aggatatcag ccttatcgcc 7561 caaaacgttt tgaaaacttt cgggcgggaa attatgataa atcccccgct tgatgtagac 7621 ctcgctgtgc tagtcgacac ttcaagcttg gaacatcttg gtaagcttgg ggagcaattg 7681 aggaagggat tacctaagct ggtggtgatt gatcaccatc gtccggtcga ggcaatgaag 7741 caactgacga ccttgtactt tgttcgggaa gagtttacct cggaggctga aattattctg 7801 cggctcatca aggagctggg ggtgaagctt acctctgagc aggcttcttt gttgctcgcc 7861 ggcatcatca gcgacaccgg acacttcagg ttcgcgaagg atgaaacatt tgaggcggtg 7921 catcagctcc tcgaggcagg gggcgattac gcgcgcgtga atgagagtct caatttatcc 7981 gaggattact ctaaacgcat cgcgatgttg aaagccgctg cgcgctcgaa gctatgccgg 8041 attcataaac gcttggtggc attttccgag ctgggctcct ttgaggggga cgcggccggg 8101 atgctggtgc gaattggggc agatgtggcg ttcgtgggct ctgaagaaaa aggagaggtg 8161 agggtcagcg ggcgagcgcg ccagaagacc ttgaagctaa cagggcttca cttgggcgaa 8221 ctcatggaag agatggggaa acagttcgag ggaagtggag gaggtcatgc gggtgcagcg 8281 agcatgcatg gcaaagggaa gcttgaggaa gtcaaaaagc atctgttcgg gttcctgcag 8341 cggaaattaa agtcgaaaaa ataacagtgg ttcgatggca gtttcggctg acgagttatc 8401 ggagttagaa ttggctgggt atcgtttcgt gggggagcac aaacacagtg cagttaaagt 8461 ctgccattgg acccggaaga gcctgctcaa ccgcggggtt tgctataaag aacggtttta 8521 tggacgagac cttggcatcc ggagccatcg atgtctccag ctcgccccca gcctaccttt 8581 ctgcgaccac cgttgcgttt actgctggag gaataccgac gttacaactc cgagctgggt 8641 cggcgaggtc gatgagccag cagatatttt ggatggggca atttcagcgc agagaaagct 8701 gctcagcggg ttcggtggca atcccaatgc agacaaaaag aagttcaagg aggctcagga 8761 accaaaacac tgtgcgatct cgttagctgg ggagccgact ttttatccta atctcagcga 8821 gttaatcgag gagtgcggta ggagggggat gactagtttt ttggtcacaa atggcatgca 8881 cccagaagtt ttggagcata tcgccgaacc cacgcagctt tatatctccg tcgtcgcccc 8941 agatcccgaa acttacgagg ttgtctgcca accaaccgtt cccgacggct ggaagcggtt 9001 gaacaagagc ttagaactca tgtcgtgttt caagtgcagg aaggcaatcc ggctaacttt 9061 agttaaaggg ctcaacctca agaaacctga agaatacgca aaaataatcg agaaagctgg 9121 ggcagatttc atagaggcca aagcctatat gttcgtcggg ttctctcgaa ggaggttggt 9181 gatggaaaac atgcccctgt ccgatgaggt aaatgggttc gccagagagt tagctaggga 9241 gacaggttac tctatcgcag gagagtctag gccaagccgg gtggtactgt taaaaaaagc 9301 ataagcggtg ggttcttctt atcatgtctt gtctttttaa gaagaattac catgcagggc 9361 ctttatgctt ttcttcttcc caccgctttc taaccgtttc agcgtatcgg ttgtagtttt 9421 caatgatgtt ctcccagata ccctcgccag tccattcttg tttcatgttt tcccatcgat 9481 ttctccacgt gtaccactgg gttgcgaact cgggctccca ctcttcagcg ttttctagga 9541 ttctttcagc gttgccaagg tgaatttttg cggcgtggat cagggcaagc gctcttctaa 9601 tctttccttc ctcgtaggca gccaccgctt tgtctttaag gccaatagcc acttcaacca 9661 atcgttccgc tgcgtgtttg ccgtgggcat tttctggggc accctctagc attatttgga 9721 cttcggccag caaattatcg aactcttcca gcttattctc gaatgcctca cttagatctg 9781 ggagattttc tgcacttatg tcgacctcaa cgttcaccgt gatgtctaca tcgacaagca 9841 cattatcgat gtcgaaatac acgtccacat ccatcggttt gtggatttgc gcgcggtacc 9901 tattcgcgat gttctctgtt atttctctga tcagccgcaa acgtgcccgg atttgtgcgc 9961 gtagctcaag cttgtcccag ttttcttcga agttttcaca ctctcggatg cagttttcaa 10021 accactcagc ttcgggagtg ttttcaagct cttgcctgag ctgctggcat agttctttgc 10081 acaaccttag ctgcaccatg ccaatttcag gcatttgctc ttgcatccat tgcactatct 10141 ctcgttttgt ttcaacatct cccggaacaa catagcgcat tttttccacg aattcttcga 10201 gtatgctctt atgagctagg ccctttccgc gatttactaa actgacatac tctccccagc 10261 gttctttcat ttgatcctcg ccgccgacca tacgaatttg ctcgcctagg cgctcaagcc 10321 cgtagaacgg tgagtcaggg tcgacatcca cagcgtccac tatcacggga gttgccactc 10381 ccgcgccaat tgacgcggca acgattacta ttgctgttat cgccgcgaca cccctttgct 10441 cagttccaaa catttttttt ctcctctttt tcattcgggt ttagctcccc gcgcggcccc 10501 tatagcgcgc gcagttcatt gatttgtatg agattttggg aaaaggggta tttaccaaat 10561 cccgaaagac cgtccaattc gaattcagtt atggtcctag cggctgattt gtaattaaaa 10621 accaattatt tttcctcctt atcgttcaaa taaacctaat aactctgatt tttgtttttg 10681 gggccgcttc tgcttctaaa aatatttata cggctacaat gcccatattg tctaactgat 10741 gacgattcgg gaagcatttg gcatagttgc gctggtcgtg atactccaac tttgcttggg 10801 tgcgctgatt tacgttataa caccaactcc cggcttggac ctatactcta ttgtcatcgc 10861 gatcgcagta atggtggccg tcgctggatc aattgcggcg gtgctagttt tcttcttcaa 10921 acgctacgct tccgagcgca ccttgcgggt agcgttgatg gcattgaccc cggacgagcg 10981 tctcgtcttt gaggccatct tgcgcgcggg agaagcccgt caagacaagc tcaggcgcga 11041 gctcgacatg tccaagtcca agctaagcgc cctcgtaaac aacctcgaac ggaagcacgc 11101 gataacgaag acgcgttatt ttaagacgaa tattttgagg gtgagcaagg agttcagcgg 11161 gcggtagaca aggcgggact cttctcctaa gtgactaaga tttcgtctgt tgctggttat 11221 ttacattgtc cctttgcgta agccttgaat aggccggccg cctaggtaga taggggtaga 11281 cttgaaagaa atgctcgaac ggatgcgcaa gcacttcgac gctcaagaga agcttcgtga 11341 gagggtgctg gatgcatcgc gagaggttat caggttttcc gcccgggcta tagccgcgac 11401 tcatcgggag aatcaatcta gcgctgacga gttcttggca aaggctcgcg atacacttgc 11461 gactcttgcg gaagcggtga aggctgagcc tcacctagct aattctggca tcatcctcgc 11521 agcttaccag gagtacggtg aagccacgct agttcgggca ctaatccgtg atggaaaact 11581 gttgacgcca gaggaactta gcatccccta taaatcttac ctcgcagctc tcgcggatac 11641 tgtgggtgag ctccgacggc acgtgctcga cttgataaga gccgacgagg tcgagcgggc 11701 tgagcaagcg ctcaagctca tggaggaaat atttgaactg ttgatggagt tcgattaccc 11761 ggatgctatt ttgcccggaa tgaagcggaa gcaagacatg gttcggcgag tgattgagca 11821 cacgcggggg gacctgccat caggcagcga aagcttgaac gtactcttga gcgggccgag 11881 cgagggaagt agtgaatgac aaaattcaac atacgaaagc taagagcgag cgcgaagaaa 11941 gattacgaga gcgcttggct tgaaagcgcc aaattggtgg agaaaagggg gaaacttttt 12001 tcactcaagg ataaaacaaa aacccatccc ttgttcgaac taattgagcg agcacgtcgt 12061 gtcctgcttg agcttggctt cgctgagaca gttttgccaa tgattgtgga caagaaggaa 12121 gtttatgccc agtatggacc tgaagcgcct gtcatccttg atcgagtttt cttcctcgcg 12181 gggctggagc gcccagatat aggcatcagt caaaagaaaa tccaagaaat ccgcgagctg 12241 gtaccggact ttaaggagat tgagaaactt caagggattt tcaggcggta taaacgaggg 12301 gagatagtag cggacgactt ggtcgaggtt atggtgaaag agctagacat acgcgaggaa 12361 caggcaaccg ggctacttgc gctttttgga gaacttaggg agctgaagcc cgtgccgatg 12421 gacctaacat tacgatcaca taccacggcg ggttggtttt tggttttacg cgagctgcag 12481 cgacgcgaat cgttgccgct ccagctattc tcaatcggtc caaagttcag gcgggagcag 12541 cggctagacc cgacgcatct ctatgagtcg tggacagcct cgatggtcat cgctgctgaa 12601 aagataagcc ttgaggacgg tgagcgaata acccgaaaaa tattggacaa gctgggattc 12661 tcggaagtga agttctcgat aaaaactgcg acttcgaagt actatgcacc acaaatggag 12721 ttcgagattt tcgtcaaaca ccccaagaca ggcgagttta tagaggtggg cgatgcgggg 12781 ttctacagcc cagtcgcgct cagccattat gacatcgctt tccccgtctt caacctcggc 12841 atagggctcg agcgcgtgct aatgatcgaa acgggcggga ccgacatacg cgttttgatg 12901 tatccctatc tctacaaagc cgctgaattc tcagacaggg agctggcaga catgataaag 12961 tgcgaacgtg agccgggcac cgagattggc cgggcgatag ccgcagcaat tgtcaaagca 13021 gcacagcagc acgccgatga gccgagccca tgcgatttca aggcgtttga aggcaaactt 13081 ggtggcaaac gagttatcgt gagagtggta gaacccgagc gtggcacgaa gctcattggg 13141 ccagcgggct tcaacgagat ttacgtttat gaaggcaacg tcgtaggtgt gccacccaag 13201 ggttgggaaa aagatgaatt tttgaattct gtgcgggaga aaggggtctc gaccggcatc 13261 agctacatca tcgctttcgc ggccctcgcg gcgcaggaaa tcgagcgagc tgcaaagagt 13321 ggtaagaagc aggtgaaggt acgcgttcgg gcagcaaaat tgccgagcga tatcaacttg 13381 gtgattgacg aggcagcaca acgctacata accgcaaaca agaagcggat tgatgttcga 13441 ggaccagttt tcaccacggt ggtcgcggag ttcggataac tacccgaaga tatctctggt 13501 cttttttatc ccctttcggg ctgcctccag cggatgtttt ggtttccaga gttcggctat 13561 cagcagccca tcatagttta tcgcccgcaa ggtgtcggct gcgggtttga agtcgatatc 13621 gccatcaccc ggcggcaggt gatcatcttc catgccgtaa ttgtcatgca catgcacatg 13681 gaccaggtgt tcgcggaggg cctcaataga tctggcaatc gcagctccgg tgcccttcct 13741 cccggctctt cgctcggcca gatgcgcgtg cccgatgtcg aaagttattt tgacccctcc 13801 tagtccggcc acaaattttc tgagttcctc aacgttcgat gggtagaaaa ttggttgccc 13861 cgcagc //