LOCUS LC739729 2178 bp DNA linear SYN 23-NOV-2023 DEFINITION Synthetic construct scR2agoTNF-Fc gene for TNFR2 agonist protein, complete cds. ACCESSION LC739729 VERSION LC739729.1 KEYWORDS . SOURCE synthetic construct ORGANISM synthetic construct other sequences; artificial sequences. REFERENCE 1 (bases 1 to 2178) AUTHORS Inoue,M. and Tsunoda,S. TITLE Direct Submission JOURNAL Submitted (18-NOV-2022) to the DDBJ/EMBL/GenBank databases. Contact:Masaki Inoue Kobe Gakuin University, The Faculty of Pharmaceutical Sciences; 1-1-3 Minatojima, Chuo-ku, Kobe, Hyogo 650-8586, Japan URL :https://www.kobegakuin.ac.jp/ REFERENCE 2 AUTHORS Inoue,M., Tsuji,Y., Ueno,R., Miyamoto,D., Tanaka,K., Moriyasu,Y., Shibata,S., Okuda,M., Ando,D., Abe,Y., Kamada,H. and Tsunoda,S.I. TITLE Bivalent structure of a TNFR2-selective and agonistic TNF-alpha mutein Fc-fusion protein enhances the expansion activity of regulatory T cells JOURNAL Sci. Rep. 13, 13762 (2023) REMARK Publication Status: Online-Only DOI:10.1038/s41598-023-40925-9 REFERENCE 3 AUTHORS Inoue,M., Yamashita,K., Tsuji,Y., Miki,M., Amano,S., Okumura,T., Kuge,K., Tone,T., Enomoto,S., Yoshimine,C., Morita,Y., Ando,D., Kamada,H., Mikami,N., Tsutsumi,Y. and Tsunoda,S.I. TITLE Characterization of a TNFR2-Selective Agonistic TNF-alpha Mutant and Its Derivatives as an Optimal Regulatory T Cell Expander. JOURNAL J. Immunol. 206, 1740-1751 (2021) REMARK DOI:10.4049/jimmunol.2000871. COMMENT FEATURES Location/Qualifiers source 1..2178 /collection_date="2021-04-15" /country="Japan" /db_xref="taxon:32630" /mol_type="other DNA" /organism="synthetic construct" CDS 1..2178 /codon_start=1 /gene="scR2agoTNF-Fc" /product="TNFR2 agonist protein" /protein_id="BDU28061.1" /transl_table=11 /translation="MVRSSSRTPSDMPVAHVVANPQAEGQLQWTNHGGNALLANGVEL RDNQLVVPSEGLYLIYSQVLFSGQGCPSTHVLLTHTISRIAVSYQTPVNLLSAIRSPC QRETPEGAEANPWYEPIYLGGVFQLEPGDRLSAEINRPDYLNFPDSGEVYFGIIALGG GSGGGVRSSSRTPSDMPVAHVVANPQAEGQLQWTNHGGNALLANGVELRDNQLVVPSE GLYLIYSQVLFSGQGCPSTHVLLTHTISRIAVSYQTPVNLLSAIRSPCQRETPEGAEA NPWYEPIYLGGVFQLEPGDRLSAEINRPDYLNFPDSGEVYFGIIALGGGSGGGVRSSS RTPSDMPVAHVVANPQAEGQLQWTNHGGNALLANGVELRDNQLVVPSEGLYLIYSQVL FSGQGCPSTHVLLTHTISRIAVSYQTPVNLLSAIRSPCQRETPEGAEANPWYEPIYLG GVFQLEPGDRLSAEINRPDYLNFPDSGEVYFGIIALGGGGSTSEPKSCDKTHTCPPCP APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAK TKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREP QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSF FLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK" BASE COUNT 501 a 666 c 617 g 394 t ORIGIN 1 atggtgcgga gctcctctag aacaccctcc gacatgcctg tggcacacgt ggtggcaaac 61 ccacaggcag agggacagct gcagtggacc aaccacggag gaaatgcact gctggcaaac 121 ggagtggagc tgagggataa tcagctggtg gtgcccagcg agggcctgta cctgatctat 181 agccaggtgc tgttctccgg acagggatgc ccttccacac acgtgctgct gacccacaca 241 atctctcgca tcgccgtgag ctaccagacc cccgtgaacc tgctgagcgc catcaggtcc 301 ccatgtcaga gggagacacc tgagggagca gaggcaaatc catggtacga gcccatctat 361 ctgggcggcg tgtttcagct ggagcctggc gacaggctga gcgccgagat caacagacca 421 gactacctga atttccccga ttccggcgag gtgtattttg gcatcatcgc cctgggagga 481 ggatctggag gaggcgtgag gagctcctct cgcaccccta gcgacatgcc agtggcccac 541 gtggtggcca atcctcaggc cgagggccag ctgcagtgga caaatcatgg cggcaacgcc 601 ctgctggcca atggcgtcga actgagagac aaccagctgg tggtgccatc tgaaggactg 661 tacctgatct attcccaggt gctgttctct ggacagggat gcccaagcac ccacgtgctg 721 ctgactcata caatcagcag aatcgccgtg tcctatcaga ccccagtgaa cctgctgtct 781 gccatccgga gcccttgtca gagagagaca ccagaaggcg ccgaagccaa cccatggtac 841 gagcctatct atctgggagg cgtgtttcag ctggaaccag gcgataggct gtctgccgag 901 atcaaccgcc ccgactacct gaatttccct gatagtggag aagtctactt cggaattatc 961 gccctgggcg gcggatccgg aggaggcgtg cggagcagct ccagaacccc atctgacatg 1021 ccagtcgccc atgtcgtggc aaacccacag gctgaaggac agctgcagtg gactaatcat 1081 ggcggcaacg ctctgctggc caatggcgtg gaactgagag acaatcagct ggtggtgcct 1141 tctgaagggc tgtacctgat ctattctcag gtgctgttca gcggccaggg ctgtccttcc 1201 actcacgtgc tgctgactca caccatctcc cggatcgccg tgtcttacca gacccctgtg 1261 aacctgctgt ccgccatcag gtctccttgc cagagggaga caccagaagg cgcagaggca 1321 aatccttggt acgagccaat ctatctgggg ggcgtgtttc aattagaacc aggcgacagg 1381 ctgtccgccg agatcaacag gccagattac ctgaacttcc cagattctgg agaagtctac 1441 tttggaatta tcgccctggg cggcggcgga agcactagtg agcccaaatc ttgtgacaaa 1501 actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc 1561 ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg 1621 gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg 1681 gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg 1741 gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag 1801 gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag 1861 ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag 1921 gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag 1981 agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc 2041 tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc 2101 ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc 2161 ctgtctccgg gtaaatga //