LOCUS AH002979 3624 bp DNA linear HUM 01-AUG-2016 DEFINITION Homo sapiens renin (REN) gene, complete cds. ACCESSION AH002979 K01169 K02218 L00064 L00065 L00066 L00067 L00068 L00069 L00070 L00071 L00072 L00073 VERSION AH002979.2 KEYWORDS renin. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 551 to 690; 929 to 1087; 1238 to 1361; 1487 to 1605; 1742 to 1938; 2138 to 2146; 2340 to 2459; 2602 to 2743; 2895 to 2993; 3192 to 3549) AUTHORS Imai,T., Miyazaki,H., Hirose,S., Hori,H., Hayashi,T., Kageyama,R., Ohkubo,H., Nakanishi,S. and Murakami,K. TITLE Cloning and sequence analysis of cDNA for human renin precursor JOURNAL Proc. Natl. Acad. Sci. U.S.A. 80 (24), 7405-7409 (1983) PUBMED 6324167 REFERENCE 2 (bases 482 to 702; 803 to 1091; 1226 to 1373; 1475 to 1617; 1730 to 1950; 2328 to 2471; 2591 to 2756; 2883 to 3005; 3180 to 3624) AUTHORS Hobart,P.M., Fogliano,M., O'Connor,B.A., Schaefer,I.M. and Chirgwin,J.M. TITLE Human renin gene: structure and sequence analysis JOURNAL Proc. Natl. Acad. Sci. U.S.A. 81 (16), 5026-5030 (1984) PUBMED 6089171 REFERENCE 3 (bases 1 to 3624) AUTHORS Miyazaki,H., Fukamizu,A., Hirose,S., Hayashi,T., Hori,H., Ohkubo,H., Nakanishi,S. and Murakami,K. TITLE Structure of the human renin gene JOURNAL Proc. Natl. Acad. Sci. U.S.A. 81 (19), 5999-6003 (1984) PUBMED 6091130 COMMENT On or before Aug 1, 2016 this sequence version replaced L00064.1, L00065.1, L00066.1, L00067.1, L00068.1, L00069.1, L00070.1, L00071.1, L00072.1, L00073.1, AH002979.1. FEATURES Location/Qualifiers source 1..3624 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /map="1q32" /dev_stage="foetus" /tissue_lib="T.Maniatis" source 1..702 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /map="1q32" /clone="lambda-GRn72" /dev_stage="foetus" /tissue_lib="T.Maniatis" source 549..690 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="pHRn[011,321]" /tissue_type="kidney" source 803..1114 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /map="1q32" /clone="lambda-HRn72" /dev_stage="foetus" /tissue_lib="T.Maniatis" source 929..1079 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="pHRn[011,321]" /tissue_type="kidney" source 1215..1373 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /map="1q32" /clone="lambda-HRn72" /dev_stage="foetus" /tissue_lib="T.Maniatis" source 1238..1361 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="pHRn[011,321]" /tissue_type="kidney" source 1474..1618 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /map="1q32" /clone="lambda-HRn72" /dev_stage="foetus" /tissue_lib="T.Maniatis" source 1487..1605 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="pHRn[011,321]" /tissue_type="kidney" source 1719..2009 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /map="1q32" /clone="lambda-HRn72" /dev_stage="foetus" /tissue_lib="T.Maniatis" source 1742..1938 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="pHRn[011,321]" /tissue_type="kidney" source 2110..2185 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /map="1q32" /clone="lambda-HRn72" /dev_stage="foetus" /tissue_lib="T.Maniatis" source 2138..2146 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="pHRn[011,321]" /tissue_type="kidney" source 2286..2489 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /map="1q32" /clone="lambda-HRn72" /dev_stage="foetus" /tissue_lib="T.Maniatis" source 2340..2459 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="pHRn[011,321]" /tissue_type="kidney" source 2590..2761 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /map="1q32" /clone="lambda-HRn72" /dev_stage="foetus" /tissue_lib="T.Maniatis" source 2602..2743 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="pHRn[011,321]" /tissue_type="kidney" source 2862..3021 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /map="1q32" /clone="lambda-HRn72" /dev_stage="foetus" /tissue_lib="T.Maniatis" source 2895..2993 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="pHRn[011,321]" /tissue_type="kidney" source 3122..3624 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /map="1q32" /clone="lambda-HRn72" /dev_stage="foetus" /tissue_lib="T.Maniatis" source 3192..3549 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="pHRn[011,321]" /tissue_type="kidney" protein_bind 93..98 /note="putative" /bound_moiety="glucocorticoid receptor complex" protein_bind 359..364 /note="putative" /bound_moiety="glucocorticoid receptor complex" gene 498..3549 /gene="REN" regulatory 498..503 /regulatory_class="CAAT_signal" /gene="REN" /note="G00-120-345" regulatory 520..525 /regulatory_class="TATA_box" /gene="REN" /note="G00-120-345" exon 549..690 /gene="REN" /note="preprorenin; G00-120-345" /number=1 CDS join(593..690,929..1079,1238..1361,1487..1605,1742..1938, 2138..2146,2340..2459,2602..2743,2895..2993,3192..3353) /gene="REN" /note="precursor" /codon_start=1 /product="renin" /protein_id="AAA60363.1" /translation="MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRE SLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVV FDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQ DIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGV LKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSV GSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDI SFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTE FDRRNNRIGFALAR" sig_peptide join(593..690,929) /gene="REN" mat_peptide join(1029..1079,1238..1361,1487..1605,1742..1938, 2138..2146,2340..2459,2602..2743,2895..2993,3192..3350) /gene="REN" /product="renin" intron order(691..>702,<803..928) /gene="REN" /note="4.1 kb gap; G00-120-345" /number=1 gap 703..802 /estimated_length=unknown exon 929..1079 /gene="REN" /note="G00-120-345" /number=2 intron order(1080..>1114,<1215..1237) /gene="REN" /note="600 bp gap; G00-120-345" /number=2 gap 1115..1214 /estimated_length=unknown exon 1238..1361 /gene="REN" /note="G00-120-345" /number=3 intron order(1362..>1373,<1474..1486) /gene="REN" /note="700 bp gap; G00-120-345" /number=3 gap 1374..1473 /estimated_length=unknown exon 1487..1605 /gene="REN" /note="G00-120-345" /number=4 intron order(1606..>1618,<1719..1741) /gene="REN" /note="900 bp gap; G00-120-345" /number=4 gap 1619..1718 /estimated_length=unknown exon 1742..1938 /gene="REN" /note="G00-120-345" /number=5 intron order(1939..>2009,<2110..2137) /gene="REN" /note="1.9 kb gap; G00-120-345" /number=5 gap 2010..2109 /estimated_length=unknown exon 2138..2146 /gene="REN" /note="G00-120-345" /number=6 intron order(2147..>2185,<2286..2339) /gene="REN" /note="600 bp gap; G00-120-345" /number=6 gap 2186..2285 /estimated_length=unknown exon 2340..2459 /gene="REN" /note="G00-120-345" /number=7 intron order(2460..>2489,<2590..2601) /gene="REN" /note="400 bp gap; G00-120-345" /number=7 gap 2490..2589 /estimated_length=unknown exon 2602..2743 /gene="REN" /note="G00-120-345" intron order(2744..>2761,<2862..2894) /gene="REN" /note="300 bp gap; G00-120-345" /number=8 gap 2762..2861 /estimated_length=unknown exon 2895..2993 /gene="REN" /note="G00-120-345" /number=9 intron order(2994..>3021,<3122..3191) /gene="REN" /note="700 bp gap; G00-120-345" /number=9 gap 3022..3121 /estimated_length=unknown exon 3192..3549 /gene="REN" /note="preprorenin; G00-120-345" /number=10 BASE COUNT 609 a 764 c 738 g 613 t ORIGIN 1 aggtgtgagc caccatgcct ggcccctcta ctcttataat taaaccagct gttgcttttc 61 ctgccaagaa accagtcatg aagattcacc catgttctag atgggaaaac tgggctgtag 121 cctgggagag gccagtcagg gacaaagcca aagttaatat agagaatgga gcttccaggg 181 tataggggtt gggtctgggc tagggagctg gaaacctagg ttttacgctt gtcccagttt 241 tgatgttagc cctgagcagt gctgtttctc atcagcctct gcctgctcca ggggtcacag 301 ggccaagcca gatagagggc tgctagcgtc actggacaca agattgcttt cccacagctg 361 tccttcctcc agcccctctg ctggggatcc ggaaacctgg gtacccttca cccacctagc 421 tctgtcccgc agtgagattt attgctgact gccctgccat ctaccccagg gtaataaatc 481 agggcagagc agaattgcaa tcaccccatg catggagtgt ataaaagggg aagggctaag 541 ggagccacag aacctcagtg gatctcagag agagccccag actgagggaa gcatggatgg 601 atggagaagg atgcctcgct ggggactgct gctgctgctc tggggctcct gtacctttgg 661 tctcccgaca gacaccacca cctttaaacg gtaattggta acnnnnnnnn nnnnnnnnnn 721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 781 nnnnnnnnnn nnnnnnnnnn nnacaagaag taactcttat aaatgctcca gaggccctca 841 gtgacagagg tgatttccag gtggctgggc taacgttaaa ggtggttgac agcacttttc 901 tatttttgct tcctccaccc tgggccagga tcttcctcaa gagaatgccc tcaatccgag 961 aaagcctgaa ggaacgaggt gtggacatgg ccaggcttgg tcccgagtgg agccaaccca 1021 tgaagaggct gacacttggc aacaccacct cctccgtgat cctcaccaac tacatggacg 1081 tgagtgcttg gctcagcccc tcgctccctc cctgnnnnnn nnnnnnnnnn nnnnnnnnnn 1141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1201 nnnnnnnnnn nnnngccctc tctttttacc cccacagacc cagtactatg gcgagattgg 1261 catcggcacc ccaccccaga ccttcaaagt cgtctttgac actggttcgt ccaatgtttg 1321 ggtgccctcc tccaagtgca gccgtctcta cactgcctgt ggtgagacct aagnnnnnnn 1381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnngtccccc tgccagtgta tcacaagctc 1501 ttcgatgctt cggattcctc cagctacaag cacaatggaa cagaactcac cctccgctat 1561 tcaacaggga cagtcagtgg ctttctcagc caggacatca tcaccgtaag ttgggccgnn 1621 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnntc ctctggtcct tcctcccaca 1741 ggtgggtgga atcacggtga cacagatgtt tggagaggtc acggagatgc ccgccttacc 1801 cttcatgctg gccgagtttg atggggttgt gggcatgggc ttcattgaac aggccattgg 1861 cagggtcacc cctatcttcg acaacatcat ctcccaaggg gtgctaaaag aggacgtctt 1921 ctctttctac tacaacaggt ggggactggg actccaaggg ctgaggtggg gggacaggag 1981 gggagaagag atggggagtg gaaggagagn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2041 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2101 nnnnnnnnnc ctttctgctg tctctctttc tctgcagaga ttccgagtaa ggagacaaaa 2161 cccccacatg gctgtgacct tccagnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2281 nnnnncttgc tgggtcctgg aggttatggg tttccaagag cttctgatct ttcctttagg 2341 aattcccaat cgctgggagg acagattgtg ctgggaggca gcgaccccca gcattacgaa 2401 gggaatttcc actatatcaa cctcatcaag actggtgtct ggcagattca aatgaagggg 2461 tcagaaatcc tcaaccctgg ggcccctccn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2581 nnnnnnnnng gcctccccca gggtgtctgt ggggtcatcc accttgctct gtgaagacgg 2641 ctgcctggca ttggtagaca ccggtgcatc ctacatctca ggttctacca gctccataga 2701 gaagctcatg gaggccttgg gagccaagaa gaggctgttt gatgtaagaa gccaaagagg 2761 gnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2821 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nactcaagaa ggctctcttt 2881 gccccccacc ccagtatgtc gtgaagtgta acgagggccc tacactcccc gacatctctt 2941 tccacctggg aggcaaagaa tacacgctca ccagcgcgga ctatgtattt caggtgaggt 3001 tcgagtcggc cccctcggtg gnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3061 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3121 ncggggtcag gcaaggtgaa aggagaatgc tcatgtgctg ggtatggaga aactctcccc 3181 cttcctgcca ggaatcctac agtagtaaaa agctgtgcac actggccatc cacgccatgg 3241 atatcccgcc acccactgga cccacctggg ccctgggggc caccttcatc cgaaagttct 3301 acacagagtt tgatcggcgt aacaaccgca ttggcttcgc cttggcccgc tgaggccctc 3361 tgccacccag gcaggccctg ccttcagccc tggcccagag ctggaacact ctctgagatg 3421 cccctctgcc tgggcttatg ccctcagatg gagacattgg atgtggagct cctgctggat 3481 gcgtgccctg acccctgcac cagcccttcc ctgctttgag gacaaagaga ataaagactt 3541 catgttcaca gcctgttgca tctgggttca ctagggttag aacagaggga ggggctgcgt 3601 gatcatgtgt ggacaggaat gtga //