LOCUS KY674977 15386 bp cRNA linear VRL 22-DEC-2023 DEFINITION Human respirovirus 3 strain HPIV3/Seattle/USA/13D1/2016, complete genome. ACCESSION KY674977 VERSION KY674977.1 DBLINK BioProject: PRJNA338014 BioSample: SAMN07309774 Sequence Read Archive: SRR5872002 KEYWORDS . SOURCE Human respirovirus 3 ORGANISM Human respirovirus 3 Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Paramyxoviridae; Feraresvirinae; Respirovirus; Respirovirus pneumoniae. REFERENCE 1 (bases 1 to 15386) AUTHORS Greninger,A.L., Makhsous,N., Kuypers,J., Shean,R.C. and Jerome,K.R. TITLE Genome sequences of viral positives at UW Virology JOURNAL Unpublished REFERENCE 2 (bases 1 to 15386) AUTHORS Greninger,A.L., Makhsous,N., Kuypers,J.M., Shean,R.C. and Jerome,K.R. TITLE Direct Submission JOURNAL Submitted (27-FEB-2017) Lab Medicine, UW, 1616 Eastlake Avenue, Suite 320, Seattle, WA 98102, USA REFERENCE 3 (bases 1 to 15386) AUTHORS Greninger,A.L., Makhsous,N., Kuypers,J.M., Shean,R.C. and Jerome,K.R. TITLE Direct Submission JOURNAL Submitted (26-APR-2017) Lab Medicine, UW, 1616 Eastlake Avenue, Suite 320, Seattle, WA 98102, USA REMARK Amino acid sequence updated by submitter FEATURES Location/Qualifiers source 1..15386 /organism="Human respirovirus 3" /mol_type="viral cRNA" /strain="HPIV3/Seattle/USA/13D1/2016" /host="Homo sapiens" /db_xref="taxon:11216" /geo_loc_name="USA" /collection_date="2016" CDS 58..1605 /codon_start=1 /product="nucleoprotein" /protein_id="ARB07846.1" /translation="MLSLFDTFNARRQENITKSAGGAIIPGQKNTVSIFALGPTITDD NEKMTLALLFLSHSLDNEKQHAQRAGFLVSLLSMAYANPELYLTTNGSNADVKYVIYM IEKDLKRQKYGGFVVKTREMIYEKTTDWIFGSDLDYDQETMLQNGRNNSTIEDLVHTF GYPSCLGAIIIQIWIVLVKAITSISGLRKGFFTRLEAFRQDGTVQAGLVLSGDTVDQI GSIMRSQQSLVTLMVETLITMNTSRNDLTTIEKNIQIVGNYIRDAGLASFFNTIRYGI ETRMAALTLSTLRPDINRLKALMELYLSKGPRAPFICILRDPIHGEFAPGNYPAIWSY AMGVAVVQNRAMQQYVTGRSYLDIDMFQLGQAVARDAEAQMSSTLEDELGVTHEAKES LKRHIRNINSSDTSFHKPTGGSAIEMAIDEEPEQFENRADQEQDGGPQSSIIQYAWAE GNRSDDRTEQATESDNIKTEQQNIRDRLNKRLNDKKKQGSQPPTNPTNRTNQDEIDDL FNAFGSN" CDS 1731..3539 /codon_start=1 /product="phosphoprotein" /protein_id="ARB07847.1" /translation="MESDAKNYQIMDSWEEESRDKSTNISSALNIIEFILSTDPQEDL SENDPINTRTQQLSATICQPEIKPTETSEKDSGSTDKNRQSGSSHECTTEAKDRNIDQ ETVQRGPGRRGSSDSRAETVVSGGISRSITDSKNGTQNTENIDLNEIRKMDKDSIEGK MRQSADVPSEISGSDGIFTTEQSRNSDHGRSLESIGTPDTRSISVVTAATPDDEEEIL MRNSRIKKSSSTHQEDDKRIKKGGKGKDWFKKSKDTDNQTSTSDHRSTSKGQKKISKT TTTNTDTKGQTEIQTEPSETQSPSWSLTIDNNTDRAEQTSPTHPTAIPRSTSTKESIR TNSESKPKTQKTNGKERKDTEESNRFTERAITLLQNLGVIQSTSKLDLYQDKRVVCVA NVLNNVDTASKIDFLAGLVIGVSMDNDTKLIQIQNEMLNLKADLKKMDESHRRLIENQ REQLSLITSLISNLKIMTERGGKKDQNESNERVSMIKTKLKEEKIKKTRFDPLMEAQG IDKNIPDLYRHAGNTLENDVQVKSEILSSYNESNATRLIPKKVSSTMRSLVAVINNSN LSQSTKQSYINELKHCKSDEEVSELMDMFNEDVNNC" CDS 1731..2850 /exception="RNA editing" /note="RNA polymerase adds non-templated Gs" /codon_start=1 /product="D protein" /protein_id="ARB07848.2" /translation="MESDAKNYQIMDSWEEESRDKSTNISSALNIIEFILSTDPQEDL SENDPINTRTQQLSATICQPEIKPTETSEKDSGSTDKNRQSGSSHECTTEAKDRNIDQ ETVQRGPGRRGSSDSRAETVVSGGISRSITDSKNGTQNTENIDLNEIRKMDKDSIEGK MRQSADVPSEISGSDGIFTTEQSRNSDHGRSLESIGTPDTRSISVVTAATPDDEEEIL MRNSRIKKSSSTHQEDDKRIKKGGGKGKTGLRNQKTLTTRHQHQITDLHQKGKRKSQR QQLLTPTQRGKQKYKQNHQKHNLHHGVSPSTTTLTELNRQAQLIQQPFPDQLVQKNQS EQTLNPSPRHKRQMERKGRIQKRAIDLQRGQLLYCRILV" CDS 1741..2340 /codon_start=1 /product="C protein" /protein_id="ARB07849.1" /translation="MLKTIKSWILGKRNQEINQLISPRPSTSLNSYSAPTPKKTYRKT TQSTQEPSNSVPLSVNQKSNQQKQVKKIVDQLTKIDSLGHHTNVQQKQKIEILIRKLY REDLGEEAAQIVELRLWSLEESPEASQILKMEPKTRRILISMKLERWIRTLLRGKCDN LQMFQARYQEVMAYLQQNKVETVIMEEAWNLSVHLIQDQ" CDS 3700..4761 /codon_start=1 /product="matrix protein" /protein_id="ARB07850.1" /translation="MSITNSAIYTFPESSFSENGHIEPLPLKVNEQRKAVPHIRVAKI GNPPKHGSRYLDVFLLGFFEMERIKDKYGSVNDLDSDPSYKVCGSGSLPIGLAKYTGN DQELLQAATKLDIEVRRTVKAKEMVVYTVQNIKPELYPWSSRLRKGMLFDANKVALAP QCLPLDRSIKFRVIFVNCTAIGSITLFKIPKSMASLSLPNTISINLQVHIKTGVQTDS KGVVQILDEKGEKSLNFMVHLGLIKRKVGRMYSVEYCKQKIEKMRLIFSLGLVGGISL HVNATGSISKTLASQLVFKREICYPLMDLNPHLNLVIWASSVEITRVDAIFQPSLPGE FRYYPNIIAKGVGKIKQWN" CDS 5019..6638 /codon_start=1 /product="fusion glycoprotein F0" /protein_id="ARB07851.1" /translation="MPISILLIITTMIMASHCQIDITKLQHVGVLVNSPKGMKISQNF ETRYLILSLIPKIEDSNSCGDQQIKQYKRLLDRLIIPLYDGLRLQKDVIVTNQESNEN TDPRTERFFGGVIGTIALGVATSAQITAAVALVEAKQARSDIEKLKEAIRDTNKAVQS VQSSVGNLIVAIKSVQDYVNKEIVPSIARLGCEAAGLQLGIALTQHYSELTNIFGDNI GSLQEKGIKLQGIASLYRTNITEIFTTSTVDKYDIYDLLFTESIKVRVIDVDLNDYSI TLQVRLPLLTRLLNTQIYKVDSISYNIQNREWYIPLPSHIMTKGAFLGGADVKECIEA FSSYICPSDPGFVLNHEMESCLSGNISQCPRTTVTSDIVPRYAFVNGGVVANCITTTC TCNGIGNRINQPPDQGVKIITHKECNTIGINGMLFNTNKEGTLAFYTPDDITLNNSVA LDPIDISIELNKAKSDLEESKEWIRRSNQKLDSIGSWHQSSTTIIVILIMMIILFIIN ITIITIAIKYYRIQKRNRVDQNDKPYVLTNK" CDS 6753..8471 /codon_start=1 /product="hemagglutinin-neuraminidase" /protein_id="ARB07852.1" /translation="MEYWKHTNHGKDAGNELETSTATHSNKLTNKITYILWTITLVLL SIVFIIVLTNSIKSERARESLLQDINNEFMEVTEKIQVASDNTNDLIQSGVNTRLLTI QSHVQNYIPISLTQQISDLRKFISEITIRNDNQEVPPQRITHDVGIKPLNPDDFWRCT SGLPSLMKTPKIRLMPGPGLLAMPTTVDGCVRTPSLVINDLIYAYTSNLITRGCQDIG KSYQVLQIGIITVNSDLVPDLNPRISHTFNINDNRKSCSLALLNTDVYQLCSTPKVDE RSDYASSGIEDIVLDIVNYDGSISTTRFKNNNISFDQPYAALYPSVGPGIYYKGKIIF LGYGGLEHPINENAICNTTGCPGKTQRDCNQASHSPWFSDRRMVNSIIVVDKGLNSVP KLKVWTISMRQNYWGSEGRLLLLGNKIYIYTRSTSWHSKLQLGIIDITDYSDIRIKWT WHNVLSRPGNNECPWGHSCPDGCITGVYTDAYPLNPTGSIVSSVILDSQKSRVNPVIT YSTATERVNELAIRNKTLSAGYTTTSCITHYNKGYCFHIVEINHKSLNTFQPMLFKTE IPKSCS" CDS 8593..15294 /codon_start=1 /product="RNA-directed RNA polymerase L" /protein_id="ARB07853.1" /translation="MDTESNNGTVSDILYPECHLNSPIVKGKIAQLHTIMSLPQPYDM DDDSILVITRQKIKLNKLDKRQRSIRRLKLILIEKVSDLGKYTFIRYPEMSKEMFKLH IPGINSKVTELLLKADRTYSQMTDGLRDLWINVLSKLASKNDGSNYDLNEEINNISKV HTTYKSDKWYNPFKTWFTIKYDMRRLQKARNEVTFNMGKDYNLLEDQKNLLLIHPELV LILDKQNYNGYLITPELVLMYCDVIEGRWNISACAKLDPKLQSMYQKGNNLWEVIDKL FPIMGEKTFDVISLLEPLALSLIQTHDPVKQLRGAFLNHVLSEMELIFESRESIKEFL SVDYIDKILDIFDKSTIDEIAEIFSFFRTFGHPPLEASIAAEKVRKYMYIEKQLKFDT INKCHAIFCTIIINGYRERHGGQWPPVTLPDHAHEFIINAYGSNSAISYENAVDYYQS FIGIKFNKFIEPQLDEDLTIYMKDKALSPKKSNWDTVYPASNLLYRTNASNESRRLVE VFIADSKFDPHQILDYVESGDWLDDPEFNISYSLKEKEIKQEGRLFAKMTYKMRATQV LSETLLANNIGKFFQENGMVKGEIELLKRLTTISISGVPRYNEVYNNSKSHTDDLKTY NKISNLNLSSNQKSKKFEFKSTDIYNDGYETVSCFLTTDLKKYCLNWRYESTALFGET CNQIFGLNKLFNWLHPRLEGSTIYVGDPYCPPSDKEHISLEDHPDSGFYVHNPRGGIE GFCQKLWTLISISAIHLAAVRIGVRVTAMVQGDNQAIAVTTRVPNNYDYRVKKEIVYK DVVRFFDSLREVMDDLGHELKLNETIISSKMFIYSKRIYYDGRILPQALKALSRCVFW SETVIDETRSASSNLATSFAKAIENGYSPVLGYACSIFKNIQQLYIALGMNINPTITQ NIKDQYFRNPNWMQYASLIPASVGGFNYMAMSRCFVRNIGDPSVAALADIKRFIKANL LDRSVLYRIMNQEPGESSFLDWASDPYSCNLPQSQNITTMIKNITARNVLQDSPNPLL SGLFTNTMIEEDEELAEFLMDRKVILPRVAHDILDNSLTGIRNAIAGMLDTTKSLIRV GINRGGLTYSLLRKISNYDLAQYETLSRTLRLIVSDKIRYEDMCSVDLAIALRQKMWI HLSGGRMISGLETPDPLELLSGVVITGSEHCKICYSSDGTNPYTWMYLPGNIKIGSAE TGISSLRVPYFGSVTDERSEAQLGYIKNLSKPAKAAIRIAMIYTWAFGNDEISWMEAS QIAQTRANFTLDNLKILTPVATSTNLSHRLKDTATQMKFSSTSLIRVSRFITMSNDNM SIKEANETKDTNLIYQQIMLTGLSVFEYLFRLKETTGHNPIVMHLHIEDECCIKESFN DEHINPESTLELIRYPESNEFIYDKDPLKDVDLSRLMVIKDHSYTIDMNYWDDTDIIH AISICTAITIADTMSQLDRDNLKEIIVIANDDDINSLITEFLTLDILVFLKTFGGLLV NQFAYTLYSLKIEGRDLIWDYIMRTLRDTSHSILKVLSNALSHPKVFKRFWDCGVLNP IYGPNTASQDQIKLALSICEYSLDLFMREWLNGVSLEIYICDSDMEVANDRKQAFISR HLSFVCCLAEIASFGPNLLNLTYLERLDLLKQYLELNIKEDPTLKYVQISGLLIKSFP STVTYVRKTAIKYLRIRGISPPEVIDDWDPIEDENMLDNIVKSINDNCNKDNKGNKIN NFWGLALKNYQVLKIRSITSDSDNNDGLDVSTGGLTLPQGGNYLSHQLRLFGINSTSC LKALELSQILMKEVNKDKDRLFLGEGAGAMLACYDATLGPAVNYYNSGLNITDVIGQR ELKIFPSEVSLVGKKLGNVTQILNRVKVLFNGNPNSTWIGNMECESLIWSELNDKSIG LVHCDMEGAIGKSEETVLHEHYSVIRITYLIGDDDVVLISKIIPTITPNWSRILYLYK LYWKDVSVISLKTSNPASTELYLISKDAYCTIMEPSEVVLSKLKRLSLLEENNLLKWI ILSKKRNNEWLHHEIKEGERDYGVMRPYHMALQIFGFQINLNHLAKEFLSTPDLTNIN NIIQSFQRTIKDVLFEWINITHDDKRHKLGGRYNIFPLKNKGKLRLLSRRLVLSWISL SLSTRLLTGRFPDEKFEHRAQTGYVSLADTDLESLKLLSKNIIKNYKECIGSISYWFL TKEIKILMKLIGGAKLLGIPRQYKEPEEQLLENYNQHDEFDID" BASE COUNT 5907 a 2580 c 2832 g 4067 t ORIGIN 1 tgaggattaa agacattgac tagaaggtca agaaaaggga actctacaat ttcaaaaatg 61 ttgagcctat ttgatacatt taatgcacgt aggcaagaaa acataacaaa atcagccggt 121 ggagctatca tccctggaca gaaaaatact gtctctatat ttgctcttgg accgacaata 181 accgatgata atgagaaaat gacattagct cttctatttt tatctcattc attagataat 241 gagaaacaac atgcacaaag agcagggttc ttggtgtctc tattgtcaat ggcttatgct 301 aatccagaac tctacttgac aacaaatgga agtaatgcag atgtcaagta tgtcatatac 361 atgattgaga aagatctaaa acggcaaaag tatggagggt ttgtggttaa gacgagagag 421 atgatatatg agaagacaac tgattggata tttggaagtg atctggatta tgatcaggaa 481 actatgttgc agaacggcag aaacaattcg acaattgaag accttgtcca cacgtttggg 541 tatccatcat gtttaggagc tattataata cagatctgga tagttttggt caaagctatc 601 actagcatct cagggttaag aaaaggcttt ttcactcgat tggaagcttt cagacaagat 661 ggaacagtgc aggcagggct ggtgttgagc ggtgacacag tggatcagat tgggtcaatc 721 atgcggtccc aacagagctt ggtaactctt atggttgaga cgttaataac aatgaatact 781 agcagaaatg atctcacaac catagaaaag aatatacaaa ttgttggtaa ctacataaga 841 gatgcaggtc tcgcttcatt cttcaataca atcagatatg gaattgagac tagaatggca 901 gctttgactc tatccactct cagaccggat ataaatagat taaaagctct aatggaactg 961 tatttgtcaa agggaccacg cgctccattc atctgtatcc tcagagatcc catacatggt 1021 gagttcgcac caggcaacta tcctgccata tggagttatg caatgggagt ggcagttgta 1081 caaaacagag ccatgcaaca gtatgtgaca ggaaggtcat atctagatat tgatatgttc 1141 cagctaggac aagcagtagc acgtgatgct gaagctcaga tgagctcaac actggaagat 1201 gaacttggag tgacacacga agccaaagaa agcttgaaaa gacatataag gaacataaac 1261 agttcagata catctttcca caaaccaaca ggtggatcag ccatagagat ggcaatagat 1321 gaagagccag aacaatttga aaatagagca gatcaagaac aagatggagg acctcaatca 1381 tccataatcc aatatgcttg ggcagaagga aacagaagtg acgaccggac tgagcaagcc 1441 acagaatctg acaatattaa gactgaacaa caaaacataa gagatagact aaacaagaga 1501 ctcaacgaca agaagaaaca aggcagtcaa ccacccacca atcctacaaa cagaacaaac 1561 caggacgaaa tagacgatct gttcaatgca tttggaagca actgatcgaa tcaatatttt 1621 gattcaaatc aataataaat aagaaaaact taggattaaa gaatcctatc acaccggaat 1681 atagagtggt aaatttagag tctgcttgca actcaatcaa cagagaattg atggaaagcg 1741 atgctaaaaa ctatcaaatc atggattctt gggaagagga atcaagagat aaatcaacta 1801 atatctcctc ggccctcaac atcattgaat tcatactcag caccgacccc caagaagacc 1861 tatcggaaaa cgacccaatc aacacaagaa cccagcaact cagtgccact atctgtcaac 1921 cagaaatcaa accaacagaa acaagtgaaa aagatagtgg atcaactgac aaaaatagac 1981 agtctgggtc atcacacgaa tgtacaacag aagcaaaaga tagaaatatt gatcaggaaa 2041 ctgtacagag aggacctggg agaagaggca gctcagatag tagagctgag actgtggtct 2101 ctggaggaat ctccagaagc atcacagatt ctaaaaatgg aacccaaaac acggagaata 2161 ttgatctcaa tgaaattaga aagatggata aggactctat tgaggggaaa atgcgacaat 2221 ctgcagatgt tccaagcgag atatcaggaa gtgatggcat atttacaaca gaacaaagta 2281 gaaacagtga tcatggaaga agcttggaat ctatcggtac acctgataca agatcaataa 2341 gtgttgtcac tgctgcaaca ccagatgacg aagaagaaat actaatgaga aatagtagga 2401 taaagaaaag ttcttcaaca caccaggaag atgacaaaag aattaaaaaa ggggggaaag 2461 ggaaagactg gtttaagaaa tcaaaagaca ctgacaacca gacatcaaca tcagatcaca 2521 gatctacatc aaaagggcaa aagaaaatct caaagacaac aactactaac accgacacaa 2581 aggggcaaac agaaatacaa acagaaccat cagaaacaca atctccatca tggagtctca 2641 ccatcgacaa caacactgac cgagctgaac agacaagccc aactcatcca acagccattc 2701 ccagatcaac tagtacaaaa gaatcaatcc gaacaaactc tgaatccaag cccaagacac 2761 aaaagacaaa tggaaaggaa aggaaggata cagaagagag caatcgattt acagagaggg 2821 caattactct attgcagaat cttggtgtaa ttcaatccac atcaaaatta gatttatacc 2881 aagacaagcg ggttgtatgt gtagccaatg tactaaataa tgtagacact gcatcaaaga 2941 tagacttcct ggcaggatta gtcatagggg tttcaatgga caacgacaca aaattgatac 3001 agatacaaaa tgaaatgtta aacctcaaag cggatctaaa gaaaatggac gaatcacata 3061 gaaggttgat agaaaatcaa agagaacaat tatcattgat cacgtcatta atttcaaatc 3121 tcaaaattat gactgagaga ggaggaaaga aagaccaaaa tgaatccaat gaaagagtat 3181 ccatgatcaa gacaaaattg aaagaggaaa agatcaagaa aaccaggttt gatccgctta 3241 tggaagcaca aggcatcgac aagaacatac ccgacctata tcgacatgca ggaaacacac 3301 tagaaaatga tgtacaagtc aaatcagaga tattaagttc atacaatgag tcaaatgcaa 3361 caagattaat acccaaaaaa gtaagcagta caatgagatc actagttgca gtcatcaaca 3421 acagcaatct ctcacaaagc acaaaacaat catatataaa cgaactcaaa cattgcaaaa 3481 gtgatgaaga agtatctgaa ttaatggaca tgttcaatga ggatgtcaat aattgctaat 3541 gatccaataa agaaacaaca ccgaataaat agacaagaaa caacagtagt tcaaaacctg 3601 tcaatacaca cgaaatcaag cagaacgaaa caatagacat caatcaatat acaaataaga 3661 aaaacttagg attaaagaat aaattaatcc ttgtccaaaa tgagtataac taactctgca 3721 atatacacat tcccagaatc atcattttcc gagaatggtc atatagaacc attaccactc 3781 aaagtcaatg aacagagaaa ggcagtacct cacattagag ttgccaaaat tggaaatcca 3841 ccaaaacacg gatcccggta tttagatgtc tttctacttg gcttcttcga gatggaacga 3901 atcaaagata aatacgggag tgtgaatgat cttgacagtg acccgagtta caaagtttgt 3961 ggctctggat cattaccaat cggactggcc aaatacactg ggaatgacca ggaattattg 4021 caggctgcaa ccaaattaga tatagaagtg agaagaacag tcaaagcaaa agagatggtt 4081 gtctatacag tacaaaatat aaaaccagaa ctgtacccat ggtctagtag actaagaaaa 4141 ggaatgctgt tcgatgccaa caaagttgct cttgctcctc aatgtcttcc actagatagg 4201 agcataaaat tcagagtaat cttcgtgaat tgtacggcaa ttggatcaat aactttgttc 4261 aaaattccta agtcaatggc atcactatct ctacctaaca caatatcaat caatctgcag 4321 gtacacatca aaacaggggt tcagactgac tccaaagggg tagttcagat tctggatgag 4381 aaaggtgaaa aatcactaaa tttcatggtc catctcggat tgatcaaaag aaaagtaggc 4441 agaatgtact ctgttgagta ctgtaaacag aaaatcgaga aaatgagatt gatattttct 4501 ttgggattag ttggaggaat cagtcttcat gtcaatgcaa ctggatctat atcaaaaaca 4561 ctagcaagtc agctagtatt caagagggag atttgttatc ctttaatgga cctaaatccg 4621 catctcaatc tagttatttg ggcttcatca gtagagatta caagagtgga tgcaattttc 4681 caaccttctt tacctggcga gttcagatac tatcctaaca ttattgcaaa aggagtcggg 4741 aaaatcaaac aatggaatta ataatcttca ctttgatcta gatataccca ctaagccaga 4801 gcaaacaaag gataatcaaa aacttaggac aaaagaagtc aacaccaaca actgtcagca 4861 gtcatacctg tcggaacaac aaagaaaagg cataaaaagt caaatagaag aaatcaaaac 4921 aaaaagcata gaacaccaga acaacaagat caaaacatcc aatttactca aaacaaaaat 4981 tccaaaagag accggcaaca caacaagcac cgaacacaat gccaatttca atactgttaa 5041 ttattacaac catgatcatg gcatcacact gccaaataga catcacaaaa ctacagcatg 5101 taggtgtatt ggtcaacagt cctaaaggga tgaagatatc acaaaacttc gaaacaagat 5161 atctaatcct gagtctcata ccaaaaatag aagattctaa ctcttgtggt gaccaacaga 5221 tcaagcaata caagaggtta ttggatagac tgatcattcc tttatatgat ggactaagat 5281 tacagaagga tgtgatagtg actaatcaag aatccaatga aaacactgat cccagaacag 5341 aacgattctt tggaggggta attggaacta ttgctctagg agtagcaacc tcagcacaaa 5401 ttacagcagc agttgctctg gttgaagcca agcaggcaag atcagacatt gaaaaactca 5461 aggaagcaat cagggacaca aataaagcag tgcagtcagt tcaaagctct gtaggaaatt 5521 tgatagtagc aattaaatca gtccaggatt atgtcaacaa agaaatcgtg ccatcgattg 5581 cgagactagg ttgtgaagca gcaggacttc agttagggat tgcattaaca cagcattact 5641 cagaattaac aaatatattt ggtgataaca taggatcgtt acaagaaaaa ggaataaaat 5701 tacaaggtat agcatcatta taccgcacaa atatcacgga aatattcaca acatcaacag 5761 ttgacaaata tgatatttat gatctattat ttacagaatc aataaaggtg agagttatag 5821 atgttgattt gaatgattac tcaataaccc tccaagtcag actcccttta ttgaccagac 5881 tgctgaacac tcaaatctac aaagtagatt ccatatcata caatatccaa aatagagaat 5941 ggtatatccc tcttcccagc catatcatga cgaaaggggc atttctaggt ggagcagatg 6001 tcaaagaatg catagaagca ttcagcagtt atatatgccc ctctgatcca ggatttgtgc 6061 taaaccatga aatggagagc tgtctatcag gaaacatatc ccaatgtcca agaaccacag 6121 tcacatcaga catagttcct aggtatgcat ttgtcaatgg aggagtggtt gcgaattgta 6181 taacaactac atgtacatgc aatggtatcg gtaatagaat caaccaacca cctgatcaag 6241 gagtcaaaat tataacacat aaagaatgta atacaatagg tatcaacgga atgctattca 6301 acacaaacaa agaaggaact cttgcattct acacaccaga cgacataaca ttaaacaatt 6361 ctgttgcact tgatccgatt gacatatcaa tcgagctcaa caaggccaaa tcagatctag 6421 aggaatcaaa agaatggata agaaggtcaa atcaaaagct agactctatt ggaagttggc 6481 atcaatctag cactacaatc atagttattt tgataatgat gattatattg tttataatta 6541 atataacaat aattacaatt gcaattaagt attacagaat tcaaaagaga aatcgagtgg 6601 atcaaaatga taagccatat gtattaacaa acaaatgaca catctgtaga tcattaaata 6661 ttaaaattat aaaaaactta ggagtaaagt tacgcaactc aactccactc atataattga 6721 gaaagaaccc aacagacgaa tccaaattcg aaatggaata ctggaagcac accaaccacg 6781 gaaaggatgc tggtaatgag ctggagacat ccacagccac tcatagcaac aagctcacca 6841 acaagataac atatatattg tggacgataa ccctggtgtt attatcaata gtcttcatca 6901 tagtgctaac taattccatc aaaagtgaaa gggcccgcga atcattgcta caagacataa 6961 ataatgagtt tatggaagtt acagaaaaga tccaagtggc atcggataat actaatgatc 7021 taatacagtc aggagtgaat acaaggcttc ttacaattca gagtcatgtc cagaattata 7081 taccaatatc attgacacaa caaatatcgg atcttaggaa attcattagt gaaattacaa 7141 ttagaaatga taatcaagaa gtgccaccac aaagaataac acatgatgtg ggtataaaac 7201 ctttaaatcc agatgatttc tggagatgta cgtctggtct tccatctttg atgaaaactc 7261 caaaaataag attaatgccg ggaccaggat tattagctat gccaacgact gttgatggct 7321 gtgtcagaac cccgtcctta gtgataaatg atctgattta tgcttacacc tcaaatctaa 7381 ttactcgagg ttgccaggat atagggaaat catatcaagt attacagata gggataataa 7441 ctgtaaattc agatttggta cccgacttaa atcctaggat ctctcatacc ttcaacataa 7501 atgacaatag aaagtcatgt tctctagcac tcctaaatac agatgtatat caactgtgtt 7561 caactccgaa agttgatgaa agatcagatt atgcatcatc aggcatagaa gatattgtac 7621 ttgatattgt caattatgat ggatcaatct ctacaacaag atttaagaat aataatataa 7681 gctttgatca accgtatgcg gcattatacc catctgttgg accagggata tactacaaag 7741 gcaaaataat atttctcggg tatggaggtc ttgaacatcc aataaatgag aatgcaatct 7801 gtaacacaac tgggtgtcct gggaaaacac agagagactg taatcaagca tctcatagtc 7861 catggttttc agatagaagg atggtcaact ctataattgt tgttgacaag ggcttgaact 7921 cagttccaaa attgaaggta tggacgatat ctatgagaca aaattactgg gggtcagaag 7981 gaagattact tctactaggt aacaagatct acatatacac aagatctaca agttggcaca 8041 gcaagttaca attaggaata attgacatta ctgactacag tgatataagg ataaaatgga 8101 catggcataa tgtgctatca agaccaggaa acaatgaatg tccatgggga cattcatgtc 8161 cggatggatg tataacggga gtatataccg atgcatatcc actcaatccc acaggaagca 8221 ttgtatcatc tgtcatattg gactcacaaa aatcgagagt caacccagtc ataacttact 8281 caacagcaac cgaaagggta aacgagctgg ctatccgaaa caaaacactc tcagctgggt 8341 atacaacaac aagctgcatt acacactata acaaagggta ttgttttcat atagtagaaa 8401 taaatcataa aagcttaaac acatttcaac ccatgttgtt caaaacagag attccaaaaa 8461 gctgcagtta atcatgatta accataatat gtattaacct atctataata caagtatatg 8521 ataattaatc agcaatcaga caatagacaa aaggggaata taaaaaactt aggagcaaag 8581 cgtgctcgaa acatggacac tgaatctaac aatggcactg tgtctgacat actctatcct 8641 gagtgtcacc ttaactctcc tatcgttaaa ggcaaaatag cacaattaca cacaattatg 8701 agtctacctc aaccttatga tatggatgac gactcaatac tagttatcac tagacagaaa 8761 ataaaactca ataaattaga taaaagacaa cgatcaatta gaagattaaa attaatatta 8821 attgagaaag tgagtgattt aggaaaatac acgtttatca gatacccaga aatgtcaaaa 8881 gaaatgttca aattacatat acccggcatt aacagtaaag tgaccgaact attacttaaa 8941 gcagatagaa catatagtca aatgactgat ggattgagag atctatggat taatgtgcta 9001 tcgaaattag cctcaaaaaa tgatggaagc aattatgatc ttaatgaaga aattaataat 9061 atatcaaaag ttcacacaac ttataaatca gataaatggt ataatccatt caagacatgg 9121 tttaccatca agtatgatat gaggagacta caaaaagctc gaaatgaggt cacctttaat 9181 atgggaaaag attataacct gttagaagac cagaagaatc tcttattgat acatccagaa 9241 ttggttttga tattagataa acaaaactat aatggttatc taattactcc tgaattagta 9301 ttgatgtatt gtgacgtaat cgaaggccga tggaatataa gtgcatgcgc taaattagat 9361 ccaaaattac aatctatgta tcagaaaggt aataatctgt gggaagtgat agataaattg 9421 tttccaatta tgggagagaa gacatttgat gtaatatcat tattagaacc acttgcatta 9481 tccctaattc aaactcatga tcctgtcaaa caactaaggg gagctttttt aaatcatgtg 9541 ttatctgaga tggaattgat atttgaatct agagaatcga tcaaggaatt tctaagtgta 9601 gattacattg ataaaatttt agatattttt gataaatcta caatagatga aatagcagag 9661 attttctctt tttttagaac atttgggcat cctccattag aggctagtat tgcagcagaa 9721 aaggttagaa aatatatgta tattgagaaa caattaaaat ttgacactat taataaatgt 9781 catgctattt tctgtacaat aataattaat ggatatagag agaggcatgg tggacagtgg 9841 cctcctgtga cattacctga tcatgcacac gaattcatca taaatgctta cggttcaaat 9901 tctgcaatat catatgaaaa tgctgttgat tattaccaga gctttatagg aataaaattt 9961 aataaattta tagaacctca gttagatgag gatttgacaa tttatatgaa agataaagca 10021 ttatctccaa aaaaatcaaa ctgggacacc gtttatcctg catctaattt actgtatcgt 10081 actaatgcat ccaacgaatc acgaagatta gttgaagtat ttatagcaga tagtaaattt 10141 gatcctcatc agatattaga ttatgtagaa tctggggatt ggttagatga tccagaattt 10201 aatatttctt atagtctcaa agaaaaggag atcaaacaag aaggtagact ctttgcaaaa 10261 atgacataca aaatgagagc tacacaggtt ttatcagaga cactacttgc aaacaatata 10321 ggaaaattct ttcaagaaaa tgggatggtg aagggagaga ttgaattact taagagatta 10381 acgactatat caatatcagg agttccacga tataatgaag tgtacaataa ttctaaaagc 10441 catacagatg atcttaaaac ttataataaa ataagtaatc ttaatttatc ctctaatcaa 10501 aaatcaaaga agtttgaatt caagtcaacg gatatttaca atgatggata tgagactgtg 10561 agctgtttcc taacaacaga tctcaaaaaa tactgtctta actggagata tgaatcaacg 10621 gctctatttg gagaaacttg caatcaaata tttggattaa ataaattgtt taattggtta 10681 catcctcgcc ttgaaggaag tacaatctat gtaggtgatc cttactgtcc tccatcagat 10741 aaagaacata tatcattaga ggatcaccct gattctggat tttacgttca taatccaaga 10801 gggggtatag aaggattttg tcaaaaattg tggacactta tatccataag tgcaatacat 10861 ctagcagctg ttaggatagg tgtgagggtg actgcaatgg ttcaaggaga caatcaagcc 10921 atagctgtaa ccacaagagt acctaacaat tatgactaca gagttaagaa ggagatagtt 10981 tataaagatg tggtgagatt ttttgattca ttaagagagg tgatggatga tctaggtcat 11041 gaacttaaat taaatgaaac gattataagt agcaagatgt tcatatatag caaaagaata 11101 tattatgatg ggagaattct tcctcaagct ctgaaagcat tatctagatg tgtcttctgg 11161 tcagaaacag taatagatga aacaagatca gcatcttcaa acttggcaac atcatttgca 11221 aaagcaattg agaatggtta ttcacctgtt ctaggatatg catgctcaat ttttaagaat 11281 attcaacaac tgtatattgc ccttgggatg aatatcaatc caactataac acagaatatc 11341 aaagatcaat attttaggaa cccaaattgg atgcaatatg cttctttaat acctgctagt 11401 gttgggggat tcaactatat ggccatgtca agatgttttg taaggaacat tggtgatcca 11461 tcagttgctg cattagctga tattaaaaga tttattaagg cgaatctatt ggaccgaagt 11521 gttctttata ggattatgaa tcaagaacca ggtgagtcat cttttttgga ctgggcttca 11581 gacccatatt catgcaattt accacaatct cagaatataa ccaccatgat taaaaatata 11641 acagcaagaa atgtattaca agattcacca aacccattat tatctggatt attcacaaat 11701 acaatgatag aagaagatga agaattagcc gaattcttga tggacaggaa ggtaattctc 11761 cctagagttg cacatgatat tctagataat tctctcacag gaatcagaaa tgctatagct 11821 ggaatgttag atacgacaaa atctttaatt agggttggca taaatagagg aggactgaca 11881 tatagtttat tgaggaaaat cagtaattat gatctagcac aatatgaaac actaagtagg 11941 actttgagat taattgtaag cgataaaatc aggtatgaag atatgtgttc agtagacctt 12001 gccatagcat tgcgacaaaa aatgtggatt catttatcag gaggaaggat gataagtggg 12061 ctcgaaacac ctgacccatt agaattatta tctggggtag taataacagg atcagaacat 12121 tgtaaaatat gttattcttc agatggtaca aacccatata cttggatgta tttaccgggt 12181 aatattaaaa taggatcagc agaaacaggt atatcatcat taagagttcc ttattttgga 12241 tcagtcactg atgaaagatc tgaggcacaa ttaggatata tcaaaaatct tagtaaacct 12301 gcaaaagccg caataagaat agcaatgata tatacatggg catttggtaa tgatgagata 12361 tcttggatgg aagcctcaca aatagcacaa acacgcgcaa atttcacact agacaatcta 12421 aaaattctaa caccggtagc tacatcaaca aatttatcac acagattaaa ggatactgca 12481 actcaaatga agttctccag cacatcattg atcagagtca gtagattcat aacaatgtcc 12541 aatgataaca tgtctatcaa ggaagctaac gaaaccaaag ataccaatct tatttatcaa 12601 caaatcatgt taacaggatt aagtgttttc gaatatttat ttagattgaa agaaaccaca 12661 ggacacaatc ccatagttat gcatctgcat atagaagatg agtgttgtat taaagaaagt 12721 tttaacgatg agcatatcaa tccagaatct acattagaat taattagata ccctgaaagt 12781 aacgaattta tttatgataa agacccgctc aaagatgtgg acttatcaag acttatggtt 12841 attaaagacc attcttatac aattgatatg aattattggg atgatactga cattatacat 12901 gcaatttcaa tatgtactgc aattacaata gcagatacta tgtcacaatt ggatcgagat 12961 aatctaaaag aaataatagt aattgcaaat gatgatgata ttaatagctt aatcactgaa 13021 tttttgactc ttgatatact cgtatttctc aagacatttg gtggattatt agtaaatcaa 13081 tttgcataca ctctttatag tttaaaaata gaaggtaggg acctcatttg ggattatata 13141 atgagaacac tgagagatac ctcccattca atattaaaag tactatctaa tgcattatct 13201 catcctaaag tattcaagag gttctgggat tgtggagtcc taaatcctat ctacggtcct 13261 aatactgcta gtcaagacca gataaaactt gccctctcta tatgtgaata ttcactagat 13321 ctatttatga gagaatggtt gaatggtgta tcacttgaaa tatacatttg tgacagtgat 13381 atggaagtag caaatgacag gaaacaagcc tttatttcta gacatctttc atttgtttgc 13441 tgtttagcag aaattgcatc ttttggacct aatctgttaa acttaacata cttagagaga 13501 cttgatctat tgaaacaata tcttgaatta aatatcaaag aagatcctac tcttaaatat 13561 gtacaaatat ctggattatt aattaaatcg ttcccatcaa ctgtaacata cgtgagaaag 13621 actgcaatca aatatttaag gattcgcggt attagtccac ctgaggtaat tgatgattgg 13681 gatccgatag aagatgaaaa tatgctggat aacattgtca aatctataaa tgataactgt 13741 aataaagata ataaaggaaa taaaattaac aatttctggg gactagcact taagaactat 13801 caagtcctta aaatcagatc tataacaagt gattctgata ataatgatgg actagatgtt 13861 agtacaggtg gtttgacact tcctcaagga gggaattacc tatcacatca attgaggtta 13921 tttggaatca acagcactag ttgtctgaaa gcccttgagt tatcacaaat tttaatgaag 13981 gaagttaata aagacaaaga caggctcttc ctgggagaag gggcaggagc tatgctagca 14041 tgttatgatg ccacattagg acctgcagtt aattattata attcaggttt gaatataaca 14101 gatgtaattg gtcaacgaga attgaaaata tttccttcag aggtatcatt agtaggtaaa 14161 aaattaggaa atgtgacaca gattcttaat agggtaaaag tactgttcaa tgggaatcca 14221 aattcaacat ggataggaaa tatggaatgt gagagcttaa tatggagtga attaaatgat 14281 aagtctatcg gattagtaca ttgtgatatg gagggagcta tcggtaaatc agaagaaact 14341 gttctacatg aacactatag tgttataaga attacatact tgattggaga tgatgatgtt 14401 gttttaattt ctaaaattat acctacaatc actccgaatt ggtctagaat actttatctg 14461 tacaagttat attggaaaga tgtaagtgta atatcactta aaacttctaa tcctgcatca 14521 acagaattat atctgatctc gaaagacgca tattgtacta taatggaacc tagtgaagtt 14581 gttttatcaa aacttaaaag attgtcactt ttggaagaaa ataatctatt aaaatggatc 14641 attttatcaa agaagaggaa taatgaatgg ttacatcatg aaatcaaaga aggggaaaga 14701 gattatggag ttatgagacc atatcatatg gcactacaaa tcttcggatt tcaaatcaat 14761 ttaaatcatc tggcgaaaga atttttatca actccagatc tgaccaatat caacaatata 14821 attcaaagtt tccagagaac aattaaggat gttttgttcg aatggattaa tataacccat 14881 gatgataaga gacataaatt aggcgggaga tataatatat tcccactgaa aaataaggga 14941 aagttaagac tgctatcgag aagactagta ttaagttgga tttcgttatc attatcgact 15001 cgattactta cgggtcgctt tcctgatgaa aaatttgaac atagagcaca aactggatat 15061 gtatcattag ctgatactga tttagaatca ttaaagttgt tgtcaaaaaa cattattaag 15121 aattacaaag agtgtatagg gtcaatatca tattggtttc taaccaaaga aattaaaata 15181 cttatgaaat tgattggtgg tgctaaatta ttaggaattc ctagacaata taaagaaccc 15241 gaagaacagt tattagaaaa ctacaatcaa catgatgaat ttgatatcga ttaagacaca 15301 aatacaatag agatatatct taacctttat ccccgagcct aaggatagat aaaaagtaag 15361 aaaaacatgt aatatatata taccaa //