LOCUS KX641304 16345 bp DNA linear MAM 22-AUG-2016 DEFINITION Ursus spelaeus voucher CB_C7 mitochondrion, partial genome. ACCESSION KX641304 VERSION KX641304.1 KEYWORDS . SOURCE mitochondrion Ursus spelaeus (cave bear) ORGANISM Ursus spelaeus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus. REFERENCE 1 (bases 1 to 16345) AUTHORS Fortes,G.G., Grandal-d'Anglade,A., Kolbe,B., Fernandes,D., Meleg,I.N., Garcia-Vazquez,A., Pinto-Llona,A.C., Constantin,S., de Torres,T.J., Ortiz,J.E., Frischauf,C., Rabeder,G., Hofreiter,M. and Barlow,A. TITLE Ancient DNA reveals differences in behaviour and sociality between brown bears and extinct cave bears JOURNAL Mol. Ecol. (2016) In press PUBMED 27506329 REMARK Publication Status: Available-Online prior to print REFERENCE 2 (bases 1 to 16345) AUTHORS Fortes,G.G., Aurora,G.-D., Ben,K., Daniel,F., Ioana,M.N., Ana,G.-V., Ana,P.-L.C., Silviu,C., Trino,D.T.J., Jose,O.E., Christine,F., Gernot,R., Michael,H. and Axel,B. TITLE Direct Submission JOURNAL Submitted (02-AUG-2016) Biology, Universita di Ferrara, Via L. Borsari 46, Ferrara, Emilia-Romagna I-44121, Italy COMMENT ##Assembly-Data-START## Assembly Method :: bwa v. 0.7.5a Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..16345 /organism="Ursus spelaeus" /organelle="mitochondrion" /mol_type="genomic DNA" /isolation_source="A Ceza, O Courel, Galicia" /specimen_voucher="CB_C7" /db_xref="taxon:39097" /geo_loc_name="Spain" /note="ancient DNA" D-loop complement(<1..472) tRNA 473..541 /product="tRNA-Phe" rRNA 542..1504 /product="12S ribosomal RNA" tRNA 1505..1570 /product="tRNA-Val" rRNA 1571..3149 /product="16S ribosomal RNA" tRNA 3151..3225 /product="tRNA-Leu" gene 3228..4182 /gene="ND1" CDS 3228..4182 /gene="ND1" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:4182,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="AOD42116.1" /translation="MFMINIISLVVPILLAVAFLTLVERKVLGYMQLRKGPNIVGPYG LLQPIADAMKLFTKEPLRPLTSSTTMFIMAPILALTLALTMWVPLPMPYPLVNMNLGV LFMLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVLLMNGSF TLSTLITTQEHLWLIFPTWPLAMMWFISTLAETNRAPFDLAEGESELVSGFNVEYAAG PFALFFLAEYTNIIMMNALTTILFFGAFHSPCMPELYTVNFTVKTLLLTASFLWIRAS YPRFRYDQLMHLLWKNFLPLTLALCMWHVTLPIITASIPPQM" tRNA 4183..4252 /product="tRNA-Ile" tRNA complement(4250..4322) /product="tRNA-Gln" tRNA 4324..4392 /product="tRNA-Met" gene 4393..5434 /gene="ND2" CDS 4393..5434 /gene="ND2" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:5434,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="AOD42117.1" /translation="MKPPILIIITSTIILGTTIVLFSSHWLMIWIGFEMNMLAIIPIL MKKFNPRAMEASTKYFLTQATASMLLMLGIIINLLHSGHWTISMIPNPIASTVITIAL AMKLGLSPFHFWVPEVTQGISLSSGMILLTWQKIAPLSVLYQISPSINPNLLMAMAAT SVLVGGWGGLNQTQLRKILAYSSIAHMGWMAAIMVYNPTLMILNLTIYIMMTLGTFML FMYNLSTTTLSLSHTWNKSPLIASLILALMLSLGGLPPLSGFIPKWMIIQELTKNDMI IMPMFMAITALLNLYFYMRLTYATALTMFPSANNMKMKWQFESMKKMIFLPPLIVAST MLLPLTPMLSIMN" tRNA 5435..5501 /product="tRNA-Trp" tRNA complement(5510..5578) /product="tRNA-Ala" tRNA complement(5579..5651) /product="tRNA-Asn" tRNA complement(5685..5751) /product="tRNA-Cys" tRNA complement(5751..5818) /product="tRNA-Tyr" gene 5820..7364 /gene="COX1" CDS 5820..7364 /gene="COX1" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit I" /protein_id="AOD42118.1" /translation="MFMNRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQP GALLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGTSSILG AINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWA MVSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKW SPAMMWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG FVHWFPLFSGYTLNNTWAKIHFMIMFIGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTW NTVSSVGSFISLTAVMLMIFMIWEAFASKREVAVVELTSTNIEWLHGCPPPYHTFEEP AYVMLK" tRNA complement(7361..7432) /product="tRNA-Ser" tRNA 7437..7503 /product="tRNA-Asp" gene 7504..8187 /gene="COX2" CDS 7504..8187 /gene="COX2" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit II" /protein_id="AOD42119.1" /translation="MAYPFQMGLQDATSPIMEELLHFHDHTLMIVFLISSLVLYIIST MLTTKLTHTSTMDAQEVETVWTILPAIILILIALPSLRILYMMDEVNNPSLTVKTMGH QWYWSYEYTDYEDLNFDSYMIPTQELKPGELRLLEVDNRVVLPMEMTIRMLISSEDVL HSWAVPSLGLKTDAIPGRLNQTALMAMRPGLYYGQCSEICGSNHSFMPIVLELVPLSY FEEWSASML" tRNA 8191..8258 /product="tRNA-Lys" gene 8261..8464 /gene="ATP8" CDS 8261..8464 /gene="ATP8" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="AOD42120.1" /translation="MPQLDTSTWSITILSMVLTLFIILQLKVSKYKYPEIPEPKSLLS SKKLVPWEEKWTKIYLPLLSPQR" gene 8422..9102 /gene="ATP6" CDS 8422..9102 /gene="ATP6" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="AOD42121.1" /translation="MNENLFTSFITPTMMGIPIVLLIIMFPSILFPSPSRLIDNRLVS VQQWLVRLTSKQMLSIHNHKGQTWALMLMSLILFIGSTNLLGLLPHSFTPTTQLSMNL GMAIPLWAGTVATGFRYKTKASLAHFLPQGTPSPLIPMLVIIETVSLFIQPMALAVRL TANITAGHLLIHLIGGATLALTSISTITACIAFTILVLLTILEFAVALIQAYVFTLLV SLYLHDNT" gene 9102..9885 /gene="COX3" CDS 9102..9885 /gene="COX3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9885,aa:TERM) /transl_table=2 /product="cytochrome c oxidase subunit III" /protein_id="AOD42122.1" /translation="MTHQTHAYHMVNPSPWPLTGALSALLMTSGLIMWFHFNSMLLLL LGLTTNMLTMYQWWRDIIRESTFQGHHTPAVQKGLRYGMVLFIVSEVFFFAGFFWAFY HSSLAPTPELGACWPPTGIAPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGSRKHML QALFITISLGVYFTLLQASEYYEASFTISDGVYGSTFFMATGFHGLHVIIGSTFLTVC FLRQLYFHFTSSHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS" tRNA 9886..9954 /product="tRNA-Gly" gene 9955..10301 /gene="ND3" CDS 9955..10301 /gene="ND3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:10300..10301,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="AOD42123.1" /translation="MNLILALFTNMLLASLLVLIAFWLPQLNIYAEKVSPYECGFDPM GSARLPFSMKFFLVAITFLLFDLEIALLLPLPWASQTDNLMTMLTMALLLISLLAMSL AYEWAEKGLEWAE" tRNA 10302..10370 /product="tRNA-Arg" gene 10371..10667 /gene="ND4L" CDS 10371..10667 /gene="ND4L" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="AOD42124.1" /translation="MPVVYVNIFLAFIVSLMGLLIYRSHLMSSLLCLEGMVLSLFVML TVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGTDYVQNLNLLQC" gene 10661..12038 /gene="ND4" CDS 10661..12038 /gene="ND4" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:12038,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="AOD42125.1" /translation="MLKIIFSTMMLMPLTWASKPNMIWINTTAYSLLISLISLTYLNQ LSDNSLNFSLLFFTDSLSAPLLALTTWLLPLMLMASQFHLSKETLTRKKLYITMLILL QLLLIMTFSAMELILFYILFEATLVPTLIIITRWGNQTERLNAGLYFLFYTLVGSLPL LIALLHTQNNLGSLNFLMMQYWIQPLPNSWSSIFLWLACMMAFMVKMPLYGLHLWLPK AHVEAPIAGSMVLAAVLLKLGGYGMMRITTLLNPLTSFMAYPFMMLSLWGMIMTSSIC LRQTDLKSLIAYSSVSHMALVIVAVLIQTPWSYMGATALMIAHGLTSSMLFCLANSNY ERIHSRTMILARGLQTLLPLMAAWWLLASLTNLALPPTINLIGELFVVVATFSWSNIT ITLMGTNIIITALYSLYMLITTQRGKCTDHVKSIKPSFTRENALMALHLLPLLLLSLN PKMILGPIY" tRNA 12039..12107 /product="tRNA-His" tRNA 12108..12166 /product="tRNA-Ser" tRNA 12167..12236 /product="tRNA-Leu" gene 12237..14066 /gene="ND5" CDS 12237..14066 /gene="ND5" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="AOD42126.1" /translation="MNLFTSSIIMTLLMLMMPIILTSTSTHKNKFYPQYVKTTVSYAF MVSTIPMMMFLYSGQEMIISNWHWMTIQTLKLTLSFKLDYFSMIFMPVALFVTWSIME FSIWYMHTDPNINHFFKYLLMFLITMMILVTANNLFQLFIGWEGVGIMSFLLIGWWYG RMDANTAALQAVLYNRIGDVGFIMAMAWFLLNTNAWDFQQIFAIEHENLNIPLAGLLL AATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGVFLLIRFYPLMEHNKTIQTA TLCLGAMTTLFTAACALTQNDIKKIIAFSTSSQLGLMIVTIGINQPHLAFLHICTHAF FKAMLFMCSGSIIHSLNDEQDIRKMGGLFKALPLTTTALIIGALALTGMPFLTGFYSK DLIIETANTSYTNAWALLTTLVATSMTAAYSTRIVFFVLLGQPRFNSVIVINENNPLL INSIKRLLLGSIFAGYLIFHNITPTTIPQMTMPHYLKMMALAVTMLGFILALELNSIS QTLKLDYPQNPFKFSIQLGYFPIIIHRLLPMMSLSMSQKMASMLLDAIWLENVLPKSI SYFQMKSSIMVSNQKGLIKLYFLSFMITLTLSFFVLNFHEWLP" gene complement(14041..14568) /gene="ND6" CDS complement(14041..14568) /gene="ND6" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="AOD42127.1" /translation="MMMYIVFILSTIFVMGFVGFSSKPSPIYGGLVLIISGGVGCGIV LNFGGSFLGLMVFLVYLGGMLVVFGYTTAMATEQYPEVWISNKAVLGAFIVGLLSELL IACYVLKDDEVEIVFKFNGMGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWS LLIGVLVIMEVTRGN" tRNA complement(14569..14637) /product="tRNA-Glu" gene 14642..15781 /gene="CYTB" CDS 14642..15781 /gene="CYTB" /codon_start=1 /transl_table=2 /product="cytochrome b" /protein_id="AOD42128.1" /translation="MTNIRKTHPLAKIINNSFIDLPTPSNISAWWNFGSLLGVCLILQ ILTGLFLAMHYTSDTTTAFSSITHICRDVHYGWVIRYMHANGASMFFICLFMHVGRGL YYGSYLFSETWNIGIILLLTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDL VEWIWGGFSVDKATLARFFAFHFILPFIILALAAVHLLFLHETGSNNPSGIPSDSDKI PFHPYYTIKDILGALLLTLALAALVLFSPDLLGDPDNYTPANPLSTPPHIKPEWYFLF AYAILRSIPNKLGGVLALIFSILILAIIPLLHTSKQRGMMFRPLSQCLFWLLVADLLT LTWIGGQPVEHPFIIIGQLASILYFTIPLVLMPIAGIIENNLLKW" tRNA 15782..15851 /product="tRNA-Thr" tRNA complement(15852..15916) /product="tRNA-Pro" D-loop complement(15917..>16345) BASE COUNT 5157 a 4122 c 2452 g 4614 t ORIGIN 1 tcacacataa ctgtggtgtc atgcatttgg tatcttttaa tttttagggg gggaacttgc 61 tatgactcag ctatgaccgt aaaggtctcg tcgcagtcaa ataatttgta gctgggctta 121 tttatctttc acgggtcggg catagatacc cataaggggt tactcagtcc cccccttacc 181 ccccgtaact tcaaggagct tacgcacatt tatggttgtc ttgccaaacc ccaaaaacaa 241 gactaaatgt acatgcaaac atgaagctat catatccaaa atcccacata ataagctaaa 301 attcccagcc aaataattac tgtaatcata ggcatgagac tttaaattaa gatctatcta 361 tagatatttt cttttttact ctgcttccct cctattgatt tttccgttat tatcactttt 421 ttggccacga gcttttacta aattatctct tacaaatccc aaaaccaacc acgtttattg 481 tagcttaata gtaaagcaag gcactgaaaa tgcctagacg agttatataa ctccataaac 541 ataaaggttt ggtcctggcc ttcccattag ctactaacaa gattacacat gcaagtctcc 601 gcgctccagt gaaaatgccc tttggatctt aaagcgattt gaaggagcgg gcatcaagca 661 cacctctccc cggtagctta taacgccttg cctagccacg cccccacggg atacagcagt 721 gataaaaatt aagccatgaa cgaaagttcg actaagctat gttgattaag ggttggttaa 781 tttcgtgcca gccaccgcgg ttatacgatt gacccgagtt aataggccca cggcgtaaag 841 cgtgtgaaag aaaaaaaatt ccctactaaa gttaaagttt aacccagctg taaaaagcta 901 tcagtaacac taaaataaac tacgaaagtg actttaatac tcttaaccac acgatagcta 961 agatccaaac tgggattaga taccccacta tgcttagcct taaacataaa taatttatta 1021 aacaaaatta ttcgccagag aactactagc aacagcttaa aactcaaagg acttggcggt 1081 gctttaaacc ccctagagga gcctgttctg taatcgataa accccgatag acctcaccac 1141 ctcttgctaa ttcagtctat ataccgccat cttcagcaaa cccttaaaag gaataaaagt 1201 aagcacaatc atctcgcata aaaaagttag gtcaaggtgt aacccatggg gtgggaagaa 1261 atgggctaca ttttctattc aagaacaact tacgaaagtt tttatgaaat taaaaactaa 1321 aggtggattt agtagtaaat caagaataga gagcttgatt gaataaggca atgaagcatg 1381 cacacaccgc ccgtcaccct cctcaagtga cataagccaa acataaccta ttaaaaccaa 1441 ataaaacgca agaggagaca agtcgtaaca aggtaagcat actggaaagt gtgcttggat 1501 ggatcaaagt gtagcttaaa caaagcatct ggcttacacc cagaggattt cacgcatgtg 1561 accactttga acccagagct agcccggaca acaactaacc aaactaccat aaaccaatta 1621 aacaaaacat tcaataatac aattaaagta taggagatag aaattctttt aatcggagct 1681 atagagaaag taccgcaagg gaatgatgaa agattactta aagtaataaa cagcaaagat 1741 tatcccttct accttttgca taatgagtta gccagaaata acctaacaaa gagaacttaa 1801 gctaggtccc ccgaaaccag acgagctacc tatgaacaat ccactggggt gaactcatct 1861 atgtcgcaaa atagtgagaa gatttatagg tagaggtgaa aagcctaacg agcctggtga 1921 tagctggttg cccagaatag aattttagtt caactttaaa cttgcctaca aaacttaaaa 1981 atttcaatgc aagtttaaaa tatattctaa aaaggtacag ctttttagaa tcaaggatac 2041 aaccttactt agagagtaaa tactaattaa accatagtag gcttagaagc agccatcaat 2101 taagaaagcg ttcaagctca acatccatgt caacttgata ccaaaaatat ttaattaact 2161 cctaatataa caactgggct aatctattta aatatagaag caacaatgct aatatgagta 2221 acaagaagta tttctccaac gcataagttt ataacagcaa cggataacca ctgatagtta 2281 acaataacgt agaaataatc caacaataaa acatctacca aaccaattgt taatccaaca 2341 caggtatgcg actaaggaaa gattaaaaga agtaaaagga actcggcaaa cacaaacccc 2401 gcctgtttac caaaaacatc acctccagca ttcccagtat tggaggcact gcctgcccgg 2461 tgacattagt taaacggccg cggtattttg accgtgcaaa ggtagcataa tcatttgttc 2521 tctaaataag gacttgtatg aaaggccaca cgagggttta actgtctctt acttccaatc 2581 agtgaaattg accttcccgt gaagaggcgg gaataaaata ataagacgag aagaccctat 2641 ggagctttaa ttaactagcc caaaaggatt tatttaccaa accgacagga acaacatatt 2701 ccttccatga gctaacaatt taggttgggg cgacctcgga gcataaagca acctccgagt 2761 gatattaatc tagacgtacc agtcaaaatg ctcacttact tattgatcca aaacctcttt 2821 gatcaacgga acaagttacc ctagggataa cagcgcaatc ctattcaaga gtccatatcg 2881 acaatagggt ttacgacctc gatgttggat caggacatcc taatggtgca gcagctatta 2941 agggttcgtt tgttcaacga ttaaagtcct acgtgatctg agttcagacc ggagcaatcc 3001 aggtcggttt ctatctattc aaatgacctc tcccagtacg aaaggacaag agaagtaagg 3061 cctccctcac taaggcgcct taagaccaat agatgaccta atctaaatct agtaagtcta 3121 cccccaatat tgcccaagag acagggcctt gttagggtgg cagagcccgg tgattgcata 3181 aaacttaaac ctttatactc agaggttcaa atcctctccc taatactatg tttatgatca 3241 acattatctc actagtcgta cccattctcc tcgccgtagc cttcctaaca ctagtagaac 3301 gaaaagtact gggctatata caacttcgta aaggaccaaa cattgtagga ccctatggtc 3361 tcctgcaacc tatcgcagat gctataaaac tttttaccaa agaaccctta cgcccactca 3421 catcgtctac gactatgttc attatagccc ctattctagc cctaacacta gccctgacta 3481 tatgagttcc tctaccaatg ccataccccc ttgtcaacat aaaccttgga gtattgttta 3541 tattagcaat atcaagtcta gctgtatatt ctatcctttg atcgggatga gcttcaaact 3601 caaaatacgc tctaattgga gctctacgag ccgtagccca aacaatttca tatgaagtca 3661 cactagccat catcctccta tcagtcctac taatgaatgg ctcattcaca ctttctactt 3721 taattactac tcaagagcac ctctgactaa ttttccccac atgacctctg gccataatat 3781 gatttatctc cactctagca gaaactaacc gagccccttt tgacctagca gaaggagagt 3841 cagaattagt ctcaggcttc aacgtcgagt acgcagcagg cccattcgcc ctatttttct 3901 tagcagaata taccaacatt attataataa atgccctcac gactattctg ttcttcggag 3961 catttcacag cccctgtata ccagaactat acaccgttaa cttcactgta aaaacactac 4021 tcctaacagc ttctttccta tgaatccgtg catcataccc ccgattccga tatgatcaac 4081 taatacacct actatgaaaa aatttcctac ccctcacact ggccctgtgc atgtgacatg 4141 taactctacc tattatcaca gcaagcattc ctcctcagat ataagaaata tgtctgacaa 4201 aagaattact ttgatagagt aaataataga ggttaaaatc ctcttatttc tagaattata 4261 ggaatcgaac ctaatcttaa gaactcaaaa atcttcgtgc tacctaatta caccatatcc 4321 tagagtaagg tcagctaaat aagctatcgg gcccataccc cgaaaatgtt ggttcatccc 4381 cttcccgtac taataaaacc acccattctt atcattatca catccaccat tattctagga 4441 accacgatcg ttctattcag ctcccactga ctcataatct gaattggctt tgaaatgaat 4501 atgctagcta ttatcccaat cctaatgaaa aaatttaatc cacgggccat agaagcttct 4561 acaaaatatt tcctcacaca agccactgca tccatgctcc tgatactagg cattattatc 4621 aacttactac attcaggaca ctgaacaatc tcaataatcc ccaatccaat cgcatcaact 4681 gtaatcacta ttgccctagc aataaaactt ggcctatccc cctttcactt ttgagtccca 4741 gaagtcacac aaggtatttc tttgtcctca ggaatgattc tactaacatg acaaaaaatc 4801 gcacctctat ccgtcctata tcaaatttca ccatccatca acccaaacct gctaatagca 4861 atagccgcta catccgtatt agtaggaggc tgaggaggac taaaccaaac tcaactccga 4921 aaaatcctag catactcttc aatcgctcac atgggctgaa tagctgccat catagtatac 4981 aacccaacct taataattct caatctcaca atctacatca taataacttt agggacattt 5041 atactattta tgtacaattt atctacaaca acactatcac tatcccacac atgaaataaa 5101 tcaccactaa ttgcctcact aatcctagca cttatactat cactaggcgg cctccctccc 5161 ctctcaggct ttattcccaa atgaataatc attcaagagt tgacaaaaaa tgatataatt 5221 attataccca tattcatagc catcacagct ctattaaacc tttatttcta catgcgccta 5281 acatacgcta cagcactaac aatgtttccc tcagcaaaca atataaaaat aaaatgacag 5341 tttgaaagca taaaaaaaat aatcttccta ccccctctaa tcgtagcatc aaccatactt 5401 cttccactaa ctccaatact atcaatcatg aactagagat ttaggctaaa aagaccaagg 5461 gccttcaaag tcctaagtaa gtgaaattca cttaatctct gcaactattt aaggactgca 5521 agagcatatc tcacatcaat tgaacgcaaa acaaccgctt taattaagct aagccctcct 5581 agatcggtgg gcttttgtcc cacaaaattt tagttaacag ctaaaaaccc caaacaactg 5641 gcttcaatct acttctcccg ccgcgtagga aaaaaaggcg ggagaagccc cggcagaatt 5701 gaatctgctt ctttgaattt gcaattcaat atgattattc accacagagc ttggcaaaaa 5761 gaggacttga cctctattct tagatttaca gtctaatact tttatcagcc attttaccta 5821 tgttcataaa tcggtgatta ttctctacga accataaaga cattggcacc ctttaccttc 5881 tattcggtgc atgagccgga atagtgggca ctgccctcag ccttttaatt cgtgccgagc 5941 tgggtcagcc tggggccctg ttgggggatg atcagatcta caatgtagtc gtaactgccc 6001 atgcgttcgt gataatcttc ttcatagtca tgcctattat aattgggggg ttcgggaact 6061 gattagtgcc cttaatgatc ggtgcccccg acatagcgtt tcctcgaatg aataacataa 6121 gcttctggtt actgccacca tccttcttat tgcttctggc ctcttctatg gtagaagcag 6181 gtgcaggaac tggatgaact gtctaccccc ctctagcggg taatctggcc catgcaggag 6241 catcagtaga cctaacaatc ttttctctgc acctagcagg tacctcttct attctgggag 6301 ctattaattt catcactact attattaaca tgaagccccc tgcaatatct caatatcaaa 6361 cacctctatt tgtatgatca gtcctaatca cagccgtact tcttctttta tctttgccag 6421 tcttagcagc tgggattact atactactta cagatcgaaa cctcaatact accttttttg 6481 atccagccgg agggggagac cctattttat atcaacacct gttctgattc ttcggacacc 6541 ctgaggttta catcttaatc cttcctgggt tcggaatgat ttctcacatt gtcacttatt 6601 actcaggaaa aaaagaacct tttggctata taggaatagt ctgagcgata gtatctattg 6661 gattcttggg atttatcgta tgagctcacc acatgtttac cgtaggtata gacgtcgaca 6721 cacgagctta cttcacttca gccaccataa ttattgctat cccaacagga gtcaaagtat 6781 ttagctgact agccactctg cacggaggga atattaaatg gtctcccgct atgatatgag 6841 ccctgggctt tatctttctg tttacagtag gaggccttac aggaattgtc ctagctaact 6901 cgtctctaga catcgttctc catgacacgt actatgtggt agcccatttt cactatgtgt 6961 tatcaatggg agctgttttt gccattatag gggggtttgt ccactgattc ccactatttt 7021 caggctacac gcttaataac acatgagcaa aaattcactt tataattata ttcattggag 7081 ttaacatgac attctttcct cagcattttc taggcctgtc aggaatacct cggcgatatt 7141 ccgactatcc cgatgcctac acaacatgaa atacagtatc ttctgtaggc tcattcattt 7201 cactaacagc agttatgctg ataattttca tgatttggga ggcctttgca tcaaaacgag 7261 aggtagcagt agtagaactc acttcaacta acattgaatg acttcatgga tgccctcctc 7321 catatcatac attcgaagaa cccgcctacg ttatactaaa ataagaaagg aaggagtcga 7381 accctctggg attggtttca agccaatatc ataaccacta tgtctctctc aataaagaga 7441 tattagtaaa aattacataa ctttgtcagg gttaaattat aggtgaaaat cctttatatc 7501 tttatggcat accccttcca aataggcctt caagacgcaa cttctcctat catagaggaa 7561 cttctacatt ttcatgatca tacattaata attgtgttcc taattagctc actggttctc 7621 tatattattt caactatact aaccaccaaa ctaacgcaca caagtacaat ggacgcacaa 7681 gaagtagaga cagtgtgaac tatcctgcca gctatcatcc tgattctgat tgcactccca 7741 tcactacgga tcctctacat gatggatgaa gtcaataatc cctcactaac tgtaaaaact 7801 ataggtcacc agtgatattg aagttacgag tatacagatt atgaagactt aaactttgac 7861 tcttatatga ttccgacaca agaactaaag cctggagaac tgcggctatt agaagtagac 7921 aatcgagtag tgctacccat agaaataacg atccgtatgc tgatctcgtc agaagatgtc 7981 ttgcactcat gagctgtacc atccctagga ctaaaaactg atgcaatccc aggacggcta 8041 aaccagacag ctcttatagc catgcgacca gggctatatt acggccaatg ctcagaaatt 8101 tgtggctcca atcacagttt tatacccatt gtcctcgagc tagtcccact atcctatttt 8161 gaagaatggt ccgcctcaat actatagaat cattaagaag ctaacatagc attaaccttt 8221 taagttaaag actgagaatg caaacttctc cttaatgaag atgccacaac tagatacatc 8281 aacatgatct attacaattc tatccatagt tctaacatta tttattattc tccagttaaa 8341 agtctcaaaa tataaatatc ctgagattcc cgagccgaaa tccctcttat catcaaaaaa 8401 acttgtgcct tgagaagaaa aatgaacgaa aatttattta cctcttttat caccccaacg 8461 ataatgggaa ttcctattgt acttttaatt attatattcc cgagcatttt atttccttct 8521 cccagtcgat tgatcgataa tcgcctagta tctgttcaac agtgactagt ccggctaaca 8581 tcaaaacaaa tattatccat tcacaaccac aagggacaaa cctgagcact aatattgatg 8641 tcactaatcc tatttattgg ctcaactaat cttctaggtc tattaccgca ctcattcaca 8701 cctaccacac agctgtcgat gaacctagga atggctattc ccttgtgggc aggtacagtc 8761 gctactggat tccgatacaa gaccaaagca tccctggctc actttctacc tcaaggaaca 8821 ccttcccctt taattccaat gctcgtaatt atcgaaacag ttagcctatt tatccaacct 8881 atggccttgg ccgtgcgatt aaccgctaat attactgcag gtcatttact catccatcta 8941 attgggggag ctaccttggc tctaacaagt attagcacta ttacagcctg tatcgccttc 9001 accattctag tgctactcac tattctcgag ttcgctgtag ccctcattca ggcctacgtc 9061 tttaccctgc tagtaagtct atacttacac gataacactt aatgactcac caaacacatg 9121 catatcatat agtcaatcca agcccatgac cactaacagg agccctttca gcccttctta 9181 taacatcggg gctaattata tgatttcact ttaactctat actcttgtta ttgctaggtc 9241 ttacaaccaa tatacttacc atgtatcaat ggtggcggga cattattcga gagagtacct 9301 ttcagggcca ccacactcct gccgtccaaa agggactgcg gtacggaata gtcctattta 9361 tcgtatcgga agtgttcttt ttcgcaggat tcttctgggc tttttatcac tcaagcctag 9421 cacctactcc cgaactagga gcatgctgac cacccacagg tattgctccc ctgaatccgc 9481 tagaagtgcc acttctcaat acttcagtac ttcttgcatc cggagtgtcc attacctgag 9541 ctcaccacag cttaatagaa ggaagccgca agcacatact tcaggcccta ttcattacta 9601 tctctctagg cgtatacttc acactcctgc aagcttcaga gtactatgaa gcatccttca 9661 ccatttcaga tggagtctat ggctcaactt ttttcatagc aacgggattt cacggacttc 9721 atgtaatcat tggctcaact tttctcacag tctgtttcct acgacaacta tactttcact 9781 tcacatcaag tcaccatttc ggcttcgaag cagcagcatg atattgacac ttcgtagatg 9841 tcgtatgact attcctatat gtttccatct attgatgagg atcttgcttc tttagtattg 9901 atcagtacaa ttgacttcca atcaataagc tctggcgcag tccagaaaga agcaatcaac 9961 ttaatcctag cactattcac caatatacta ctagcttccc tactcgtcct tattgccttt 10021 tggctaccac aattaaatat ctacgcagag aaagtaagcc cctacgaatg cgggtttgac 10081 cccataggat cggcacgtct ccctttttct atgaaattct tcctggtagc tattacattt 10141 ctactatttg atctagaaat tgcactactc ctcccccttc cctgagcatc acaaactgat 10201 aatctaataa cgatactcac catagcgcta ctgcttatct ccctactagc catgagtctg 10261 gcctatgaat gagctgaaaa aggtctagaa tgggccgaat atgataatta gtttaaacca 10321 aaacaaatga tttcgactca ttagattatg aataataaca taattatcaa atgcctgtag 10381 tctatgtcaa tatcttctta gcattcattg tatccctaat aggactgctc atctatcgat 10441 cccatctaat atcctccctg ctttgcctag agggtatagt gctatcctta ttcgtcatgc 10501 ttacagtaac agttttaaat aatcacttta cactggctaa tatagcccca attatcctac 10561 tggtattcgc tgcctgtgaa gcagcactag gactgtccct actagtaata gtctctaaca 10621 cttacggaac tgactatgta caaaacctca atctcttaca atgctaaaaa ttatcttttc 10681 cactataata ttaatacctc ttacatgagc atcaaaaccc aatataattt ggattaacac 10741 aacagcttac agtctactta ttagtctcat cagtttgacg tatctcaacc aactcagtga 10801 taatagccta aacttctcat tattattctt taccgactcc ctatcagctc ctctattagc 10861 cctcacaaca tgactactac ctctaatact aatggcgagt caattccacc tgtcaaagga 10921 aactctgacc cgaaagaaat tatatatcac tatactaatc ctcctacaat tactcctgat 10981 cataaccttt tctgctatag agctgatcct attctatatc ttattcgaag ccaccctagt 11041 acccactcta attattatca ctcgatgagg aaatcaaaca gaacgactaa acgcgggcct 11101 ttattttcta ttttacactc tagtggggtc tttgccatta ctaattgcac tactacacac 11161 ccaaaataat ctaggctccc taaactttct cataatacaa tactgaatcc agcctctgcc 11221 aaactcctga tccagtatct ttctatgact ggcatgtata atagcattta tggtaaaaat 11281 acctctatat ggtcttcacc tgtgattacc aaaagcacac gtagaggcac ccattgcagg 11341 gtccatagta cttgccgccg tactcctaaa actaggaggc tacggcatga tacgaattac 11401 aacattactt aatcctttaa cgagcttcat ggcttacccc ttcataatac tctcgctatg 11461 gggtataatt ataacaagtt ctatctgcct acgccaaacg gatttaaagt ccctaatcgc 11521 ttactcctct gtcagtcaca tggccctagt cattgtagca gtattaatcc aaaccccatg 11581 aagctatata ggagcaacag ccttaataat tgcccacgga ctaacatcct ccatgctatt 11641 ctgccttgca aactccaact atgaacgaat ccatagccga actataatcc ttgcgcgagg 11701 cctacaaaca cttctcccac ttatggcagc ttgatgacta ctagcaagtc tcactaacct 11761 agcactcccc cccaccatca atcttatcgg agaactattt gtagtagtag ctacattttc 11821 atggtctaac atcaccatca ctctaatagg aactaacatt atcattaccg ccctttactc 11881 cctctacata ctgatcacca cacaacgagg caagtgcaca gaccacgtca aaagtattaa 11941 accctctttc acacgagaaa acgccctgat agctctccat ctcctacccc ttctgctact 12001 atcccttaac cccaaaataa ttctaggacc catttactgt aaatatagtt taacaaaaac 12061 attagattgt gaatctaata ataaaagccg aagtcttttt atttaccgaa aaagtacgca 12121 agaactgcta actcatgcgt ccatgcataa aatcatggct ttttcaactt ttaaaggata 12181 gaagtaatcc attggtctta ggaaccaaaa aattggtgca actccaaata aaagtaatca 12241 atctgtttac ttcctctatt atcataactt tgctcatatt aatgatacca attatcctca 12301 ccagcacttc aacacacaaa aataaattct atccacaata tgtaaaaact acagtctctt 12361 atgctttcat agttagtact attcccataa tgatattcct ttactcaggg caagagataa 12421 ttatctcaaa ctgacattga ataactattc aaaccttaaa actaacccta agctttaagc 12481 tagactattt ctcaataatt ttcatgccag tagccctatt cgtcacatga tcaatcatgg 12541 aattttctat ttgatacata cacactgacc ccaacatcaa ccatttcttc aagtatctac 12601 tcatattcct tattaccata ataattttag taaccgcaaa taatctattt caactattca 12661 tcggctgaga gggagtaggg atcatatctt tcctccttat tgggtgatga tacggacgaa 12721 tagacgccaa cacagctgcc ctacaagcag tcctatataa tcgcatcgga gacgtaggct 12781 ttatcatagc catagcctga tttttactca atacgaatgc atgagacttc caacaaatct 12841 ttgcaattga acatgaaaac cttaacatcc cactagcagg actactccta gcagccactg 12901 gaaaatcagc ccaattcggc cttcacccat gactcccatc agctatagaa ggacctactc 12961 ctgtttcagc cttactccac tctagtacta tagtagtagc gggggtattt cttctaatcc 13021 gattttaccc cttgatagaa cacaacaaga ctatccaaac agccacttta tgcttaggag 13081 caataactac cctatttaca gcagcctgtg ctctcaccca gaatgatatt aaaaagatca 13141 ttgccttttc cacctcaagc cagctaggac taataattgt aacaattgga attaaccagc 13201 ctcacctagc attccttcat atctgcacac acgcattttt caaggccata ctattcatat 13261 gctctgggtc cattatccac agcctgaatg atgaacaaga catccgaaaa ataggaggcc 13321 tattcaaagc cctaccactt accactaccg cactaattat cggagctcta gcactcacag 13381 gcataccttt cctaacagga ttctactcta aagacctaat tatcgaaacc gccaacacgt 13441 cgtacaccaa cgcctgagcc ctactaacaa ctcttgttgc tacatccata accgctgcct 13501 acagtactcg aatcgtattc ttcgtacttc taggacaacc ccgctttaac tctgtcatcg 13561 ttatcaacga gaataaccct ctcctaatca actccatcaa acgtctactt ctaggaagta 13621 ttttcgcagg atacctaatc ttccacaata ttacacccac taccatccca caaataacca 13681 taccccacta tctaaaaata atagctctcg cggttactat actaggtttt atcctagcat 13741 tagaactcaa ttctatttca caaactctca aacttgacta cccacaaaat ccattcaaat 13801 tctctattca actaggatac ttccccatta ttattcaccg cctcctacca ataatgagct 13861 tatcaataag ccaaaaaatg gcatctatac tactagacgc aatctgacta gaaaatgtac 13921 taccaaaatc tatctcctat ttccaaataa aatcttcaat catagtctct aatcagaaag 13981 gattaattaa actatatttt ctctccttca tgatcacact aaccctaagc ttctttgtac 14041 ttaatttcca cgagtgactt ccataattac taacacacca ataagaagag accacccagt 14101 gacaataact aatcaagttc cataactgta taaagccgca atccctatgg cttcctcact 14161 aaaaaacccc gaatcccccg tgtcataaat tactcaatca cctatcccat taaatttgaa 14221 cacaatctca acttcatcat cctttaggac ataacaggca atcaatagct cagacaatag 14281 acccacgata aatgcaccta atacagcttt attagagatc cagacctcag ggtactgctc 14341 agtggccata gccgtagtat aaccaaaaac tacaagtatc ccacccaaat aaactaaaaa 14401 aaccattaaa cctaaaaagg atcccccaaa attcaacaca atgccacacc caacaccccc 14461 actaataatt aaaaccaacc ccccgtaaat aggagaaggc ttagaagaaa accctacaaa 14521 acccatcaca aagatagtac ttaaaataaa cacgatatac attatcatta ttctcacatg 14581 gagtctaacc atgactagtg acatgaaaaa tcaccgttgt acttcaacta caagaacctt 14641 aatgaccaac atccgaaaaa cccatccatt agctaaaatc atcaacaact cattcattga 14701 cctcccaaca ccatcaaaca tctcagcatg atgaaacttt ggatccctcc tcggagtatg 14761 cttaattcta cagatcctaa caggcctgtt tctagctata cactacacat cagacacaac 14821 cacagccttt tcatcaatca cccatatttg ccgagacgtt cactacggtt gagttatccg 14881 atatatacat gcaaacggag cctccatatt ctttatctgt ctattcatgc acgtaggacg 14941 gggcctatac tatggctcat acctattctc agaaacatga aacattggca ttattctcct 15001 acttacagtc atagccaccg cattcatagg atatgtccta ccctgaggcc aaatgtcctt 15061 ctgaggagca actgtcatta ccaacctact atcggccatt ccctatatcg gaacggatct 15121 agtagaatga atctgaggag gcttttccgt agataaggca actctagcac gattctttgc 15181 cttccacttt atcctcccgt tcatcatctt agcactagca gcagtccatc tattgtttct 15241 acacgaaaca ggatccaaca acccctctgg aatcccatct gactcagaca aaatcccatt 15301 tcacccatac tatacaatta aggacattct aggcgccctg cttctcactc tagctttagc 15361 agctctagtc ctattctcgc ctgacttact aggagaccct gacaactata cccccgcaaa 15421 cccactgagt accccacccc acatcaaacc cgagtggtac tttctatttg cctacgctat 15481 cctacgatct atccctaaca aactaggagg agtactagca ctaatcttct ccatcctaat 15541 cctagctatc attcctcttc tacacacatc caaacaacga ggaatgatat tccggcctct 15601 aagccaatgc ctattctgac tcctagtagc agacctacta acactaacat gaattggagg 15661 acaaccagta gaacacccct tcattattat cggacagcta gcctccattc tctactttac 15721 aatcccccta gtactcatac ccatcgctgg aattattgaa aacaacctct taaagtgaag 15781 agtctttgta gtatagcaat taccttggcc ttgtaagcca aaaacggaga atatttaccc 15841 tccctaagac tcaaggaaga agcaacagct ccactatcag cacccaaagc tgatgtccta 15901 cttaaactat tccctggtac ataccattat tttactctat accctattta tttcatatat 15961 accatctcat gtactgtacc atcatagtat gtccttaaat acctatgtat atcgtgcatt 16021 aatggcgtac cccatgcata taggcatgta catattatgc ttgatcttac atgaggactt 16081 acatcccaaa agtttatttc aagtgtatag tctgtaagca tgtatttcac ttagtccagg 16141 agcttaatca ccaggcctcg agaaaccagc aacccttgcg agtacgtgta cctcttctcg 16201 ctccgggccc atggaatgtg ggggtttcta tgttgaaact atacctggca tctggttctt 16261 acttcagggc catgatagct ctagattcca atcctactaa ctcttcaaat gggacatctc 16321 gatggactaa tgactaatca gccca //