LOCUS       KU177914                1818 bp    mRNA    linear   HTC 06-DEC-2015
DEFINITION  Homo sapiens v-raf murine sarcoma 3611 viral oncogene-like protein
            isoform 1 (ARAF) mRNA, partial cds.
ACCESSION   KU177914
VERSION     KU177914.1
KEYWORDS    HTC; isoform.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1818)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Trigg,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   2  (bases 1 to 1818)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Trigg,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-NOV-2015) Center for Cancer Systems Biology,
            Dana-Farber Cancer Institute, 450 Brookline Ave., Boston, MA 02215,
            USA
FEATURES             Location/Qualifiers
     source          1..1818
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="ARAF_1"
                     /tissue_type="pooled heart, liver, brain, testis and
                     placenta tissues"
     gene            1..>1818
                     /gene="ARAF"
                     /db_xref="GeneID:369"
     CDS             1..>1818
                     /gene="ARAF"
                     /note="similar to NM_001654"
                     /codon_start=1
                     /product="v-raf murine sarcoma 3611 viral oncogene-like
                     protein isoform 1"
                     /protein_id="ALQ33372.1"
                     /db_xref="GeneID:369"
                     /translation="MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDS
                     LDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFV
                     RKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQD
                     LSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNV
                     HMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPA
                     EQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVA
                     VKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYH
                     HLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGL
                     ATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLP
                     YSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILAT
                     IELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP"
BASE COUNT          376 a          581 c          500 g          361 t
ORIGIN      
        1 atggagccac cacggggccc ccctgccaat ggggccgagc catcccgggc agtgggcacc
       61 gtcaaagtat acctgcccaa caagcaacgc acggtggtga ctgtccggga tggcatgagt
      121 gtctacgact ctctagacaa ggccctgaag gtgcggggtc taaatcagga ctgctgtgtg
      181 gtctaccgac tcatcaaggg acgaaagacg gtcactgcct gggacacagc cattgctccc
      241 ctggatggcg aggagctcat tgtcgaggtc cttgaagatg tcccgctgac catgcacaat
      301 tttgtacgga agaccttctt cagcctggcg ttctgtgact tctgccttaa gtttctgttc
      361 catggcttcc gttgccaaac ctgtggctac aagttccacc agcattgttc ctccaaggtc
      421 cccacagtct gtgttgacat gagtaccaac cgccaacagt tctaccacag tgtccaggat
      481 ttgtccggag gctccagaca gcatgaggct ccctcgaacc gccccctgaa tgagttgcta
      541 accccccagg gtcccagccc ccgcacccag cactgtgacc cggagcactt ccccttccct
      601 gccccagcca atgcccccct acagcgcatc cgctccacgt ccactcccaa cgtccatatg
      661 gtcagcacca cggcccccat ggactccaac ctcatccagc tcactggcca gagtttcagc
      721 actgatgctg ccggtagtag aggaggtagt gatggaaccc cccgggggag ccccagccca
      781 gccagcgtgt cctcggggag gaagtcccca cattccaagt caccagcaga gcagcgcgag
      841 cggaagtcct tggccgatga caagaagaaa gtgaagaacc tggggtaccg ggactcaggc
      901 tattactggg aggtaccacc cagtgaggtg cagctgctga agaggatcgg gacgggctcg
      961 tttggcaccg tgtttcgagg gcggtggcat ggcgatgtgg ccgtgaaggt gctcaaggtg
     1021 tcccagccca cagctgagca ggcccaggct ttcaagaatg agatgcaggt gctcaggaag
     1081 acgcgacatg tcaacatctt gctgtttatg ggcttcatga cccggccggg atttgccatc
     1141 atcacacagt ggtgtgaggg ctccagcctc taccatcacc tgcatgtggc cgacacacgc
     1201 ttcgacatgg tccagctcat cgacgtggcc cggcagactg cccagggcat ggactacctc
     1261 catgccaaga acatcatcca ccgagatctc aagtctaaca acatcttcct acatgagggg
     1321 ctcacggtga agatcggtga ctttggcttg gccacagtga agactcgatg gagcggggcc
     1381 cagcccttgg agcagccctc aggatctgtg ctgtggatgg cagctgaggt gatccgtatg
     1441 caggacccga acccctacag cttccagtca gacgtctatg cctacggggt tgtgctctac
     1501 gagcttatga ctggctcact gccttacagc cacattggct gccgtgacca gattatcttt
     1561 atggtgggcc gtggctatct gtccccggac ctcagcaaaa tctccagcaa ctgccccaag
     1621 gccatgcggc gcctgctgtc tgactgcctc aagttccagc gggaggagcg gcccctcttc
     1681 ccccagatcc tggccacaat tgagctgctg caacggtcac tccccaagat tgagcggagt
     1741 gcctcggaac cctccttgca ccgcacccag gccgatgagt tgcctgcctg cctactcagc
     1801 gcagcccgcc ttgtgcct
//