LOCUS KM034560 18952 bp cRNA linear VRL 15-DEC-2014 DEFINITION Zaire ebolavirus isolate Ebola virus/H.sapiens-wt/SLE/2014/Makona-G3682.1, complete genome. ACCESSION KM034560 VERSION KM034560.1 DBLINK BioProject: PRJNA257197 BioSample: SAMN02951976 KEYWORDS . SOURCE Zaire ebolavirus ORGANISM Zaire ebolavirus Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Filoviridae; Orthoebolavirus; Orthoebolavirus zairense. REFERENCE 1 (bases 1 to 18952) AUTHORS Gire,S.K., Goba,A., Andersen,K.G., Sealfon,R.S., Park,D.J., Kanneh,L., Jalloh,S., Momoh,M., Fullah,M., Dudas,G., Wohl,S., Moses,L.M., Yozwiak,N.L., Winnicki,S., Matranga,C.B., Malboeuf,C.M., Qu,J., Gladden,A.D., Schaffner,S.F., Yang,X., Jiang,P.P., Nekoui,M., Colubri,A., Coomber,M.R., Fonnie,M., Moigboi,A., Gbakie,M., Kamara,F.K., Tucker,V., Konuwa,E., Saffa,S., Sellu,J., Jalloh,A.A., Kovoma,A., Koninga,J., Mustapha,I., Kargbo,K., Foday,M., Yillah,M., Kanneh,F., Robert,W., Massally,J.L., Chapman,S.B., Bochicchio,J., Murphy,C., Nusbaum,C., Young,S., Birren,B.W., Grant,D.S., Scheiffelin,J.S., Lander,E.S., Happi,C., Gevao,S.M., Gnirke,A., Rambaut,A., Garry,R.F., Khan,S.H. and Sabeti,P.C. TITLE Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak JOURNAL Science 345 (6202), 1369-1372 (2014) PUBMED 25214632 REFERENCE 2 (bases 1 to 18952) AUTHORS Goba,A., Khan,H., Momoh,M., Jalloh,S., Fullah,M., Kanneh,L., Gevao,S., Happi,C., Gire,S.K., Andersen,K., Malboeuf,C., Matranga,C., Sealfon,R., Wohl,S., Gladden,A., Yang,X., Winnicki,S., Park,D., Qu,J., Sabeti,P. and Garry,R. CONSRTM Viral Hemorrhagic Fever Consortium TITLE Direct Submission JOURNAL Submitted (16-JUN-2014) Infectious Disease Initiative, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, MA 02142, USA COMMENT ##Assembly-Data-START## Assembly Method :: Novoalign v. 3 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..18952 /organism="Zaire ebolavirus" /mol_type="viral cRNA" /isolate="Ebola virus/H.sapiens-wt/SLE/2014/Makona-G3682.1" /isolation_source="serum" /host="Homo sapiens" /db_xref="taxon:186538" /geo_loc_name="Sierra Leone" /collection_date="28-May-2014" gene 50..3020 /gene="NP" mRNA 50..3020 /gene="NP" /product="nucleoprotein" regulatory 50..61 /regulatory_class="other" /gene="L" /note="putative transcription start signal" CDS 464..2683 /gene="NP" /note="involved in encapsidation of genomic RNA" /codon_start=1 /product="nucleoprotein" /protein_id="AIE11896.1" /translation="MDSRPQKVWMTPSLTESDMDYHKILTAGLSVQQGIVRQRVIPVY QVNNLEEICQLIIQAFEAGVDFQESADSFLLMLCLHHAYQGDYKLFLESGAVKYLEGH GFRFEVKKCDGVKRLEELLPAVSSGRNIKRTLAAMPEEETTEANAGQFLSFASLFLPK LVVGEKACLEKVQRQIQVHAEQGLIQYPTAWQSVGHMMVIFRLMRTNFLIKFLLIHQG MHMVAGHDANDAVISNSVAQARFSGLLIVKTVLDHILQKTERGVRLHPLARTAKVKNE VNSFKAALSSLAKHGEYAPFARLLNLSGVNNLEHGLFPQLSAIALGVATAHGSTLAGV NVGEQYQQLREAATEAEKQLQQYAESRELDHLGLDDQEKKILMNFHQKKNEISFQQTN AMVTLRKERLAKLTEAITAASLPKTSGHYDDDDDIPFPGPINDDDNPGHQDDDPTDSQ DTTIPDVVVDPDDGGYGEYQSYSENGMSAPDDLVLFDLDEDDEDTKPVPNRSTKGGQQ KNSQKGQHTEGRQTQSTPTQNVTGPRRTIHHASAPLTDNDRRNEPSGSTSPRMLTPIN EEADPLDDADDETSSLPPLESDDEEQDRDGTSNRTPTVAPPAPVYRDHSEKKELPQDE QQDQDHIQEARNQDSDNTQPEHSFEEMYRHILRSQGPFDAVLYYHMMKDEPVVFSTSD GKEYTYPDSLEEEYPPWLTEKEAMNDENRFVTLDGQQFYWPVMNHRNKFMAILQHHQ" regulatory 3009..3020 /regulatory_class="polyA_signal_sequence" /gene="NP" gene 3026..4401 /gene="VP35" mRNA 3026..4401 /gene="VP35" /product="polymerase complex protein" regulatory 3026..3037 /regulatory_class="other" /gene="VP35" /note="putative transcription start signal" CDS 3123..4145 /gene="VP35" /note="involved in encapsidation of genomic RNA" /codon_start=1 /product="polymerase complex protein" /protein_id="AIE11897.1" /translation="MTTRTKGRGHTVATTQNDRMPGPELSGWISEQLMTGRIPVNDIF CDIENNPGLCYASQMQQTKPNPKMRNSQTQTDPICNHSFEEVVQTLASLATVVQQQTI ASESLEQRITSLENGLKPVYDMAKTISSLNRVCAEMVAKYDLLVMTTGRATATAAATE AYWAEHGQPPPGPSLYEESAIRGKIESRDETVPQSVREAFNNLDSTTSLTEENFGKPD ISAKDLRNIMYDHLPGFGTAFHQLVQVICKLGKDSNSLDIIHAEFQASLAEGDSPQCA LIQITKRVPIFQDAAPPVIHIRSRGDIPRACQKSLRPVPPSPKIDRGWVCVFQLQDGK TLGLKI" gene 4384..5888 /gene="VP40" mRNA 4384..5888 /gene="VP40" /product="matrix protein" regulatory 4384..4395 /regulatory_class="other" /gene="VP40" /note="putative transcription start signal" regulatory 4391..4401 /regulatory_class="polyA_signal_sequence" /gene="VP35" /note="putative" CDS 4473..5453 /gene="VP40" /codon_start=1 /product="matrix protein" /protein_id="AIE11898.1" /translation="MRRVILPTAPPEYMEAIYPARSNSTIARGGNSNTGFLTPESVNG DTPSNPLRPIADDTIDHASHTPGSVSSAFILEAMVNVISGPKVLMKQIPIWLPLGVAD QKTYSFDSTTAAIMLASYTITHFGKATNPLVRVNRLGPGIPDHPLRLLRIGNQAFLQE FVLPPVQLPQYFTFDLTALKLITQPLPAATWTDDTPTGSNGALRPGISFHPKLRPILL PNKSGKKGNSADLTSPEKIQAIMTSLQDFKIVPIDPTKNIMGIEVPETLVHKLTGKKV TSKNGQPIIPVLLPKYIGLDPVAPGDLTMVITQDCDTCHSPASLPAVVEK" regulatory 5877..5888 /regulatory_class="polyA_signal_sequence" /gene="VP40" gene 5894..8299 /gene="GP" regulatory 5894..5905 /regulatory_class="other" /gene="GP" /note="putative transcription start signal" mRNA join(<6033..6917,6917..>8062) /gene="GP" /product="virion spike glycoprotein precursor" /note="ribosomal slippage" CDS join(6033..6917,6917..8062) /gene="GP" /ribosomal_slippage /note="additional A residue inserted during transcription; encodes two disulfide linked subunits GP1 and GP2; receptor binding and fusion" /codon_start=1 /product="virion spike glycoprotein precursor" /protein_id="AIE11899.1" /translation="MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQ VSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSVTKRWGFRSGVPPKVVNYEAG EWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFF LYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTI RYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYASGKRSNTTGKLIWK VNPEIDTTIGEWAFWETKKNLTRKIRSEELSFTAVSNGPKNISGQSPARTSSDPETNT TNEDHKIMASENSSAMVQVHSQGRKAAVSHLTTLATISTSPQPPTTKTGPDNSTHNTP VYKLDISEATQVGQHHRRADNDSTASDTPPATTAAGPLKAENTNTSKSADSLDLATTT SPQNYSETAGNNNTHHQDTGEESASSGKLGLITNTIAGVAGLITGGRRTRREVIVNAQ PKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYTEGLMHNQDGLICGLRQLANETT QALQLFLRATTELRTFSILNRKAIDFLLQRWGGTCHILGPDCCIEPHDWTKNITDKID QIIHDFVDKTLPDQGDNDNWWTGWRQWIPAGIGVTGVIIAVIALFCICKFVF" mRNA <6033..>7127 /gene="GP" /product="sGP" CDS 6033..7127 /gene="GP" /note="sGP secreted as an anti-parallel oriented homodimer; small non-structural secreted glycoprotein" /codon_start=1 /product="sGP" /protein_id="AIE11900.1" /translation="MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQ VSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSVTKRWGFRSGVPPKVVNYEAG EWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFF LYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTI RYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYASGKRSNTTGKLIWK VNPEIDTTIGEWAFWETKKTSLEKFAVKSCLSQLYQTDPKTSVVRVRRELLPTQRPTQ QMKTTKSWLQKIPLQWFKCTVKEGKLQCRI" mRNA join(<6033..6916,6918..>6927) /gene="GP" /product="ssGP" /note="ribosomal slippage" CDS join(6033..6916,6918..6927) /gene="GP" /ribosomal_slippage /note="one A residue is deleted or two additional A residues are inserted at the editing site during transcription; second non-structural secreted glycoprotein; secreted in a monomeric form" /codon_start=1 /product="ssGP" /protein_id="AIE11901.1" /translation="MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQ VSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSVTKRWGFRSGVPPKVVNYEAG EWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFF LYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTI RYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYASGKRSNTTGKLIWK VNPEIDTTIGEWAFWETKKPH" misc_feature 7520..7534 /gene="GP" /note="cleavage site; precursor GP is cleaved by subtilisin-like cellularprotease furin into subunits GP1 and GP2 that are linked by a disulfide bond" misc_feature 7784..7864 /gene="GP" /note="immunosuppressive motif" gene 8282..9734 /gene="VP30" mRNA 8282..9734 /gene="VP30" /product="VP30" regulatory 8282..8293 /regulatory_class="other" /gene="VP30" /note="putative transcription start signal" regulatory 8289..8299 /regulatory_class="polyA_signal_sequence" /gene="GP" /note="putative" CDS 8503..9369 /gene="VP30" /note="minor nucleoprotein; polymerase complex protein" /codon_start=1 /product="VP30" /protein_id="AIE11902.1" /translation="MEASYERGRPRAARQHSRDGHDHHVRARSSSRENYRGEYRQSRS ASQVRVPTVFHKKRVEPLTVPPAPKDICPTLKKGFLCDSSFCKKDHQLESLTDRELLL LIARKTCGSVEQQLNITAPKDSRLANPTADDFQQEEGPKITLLTLIKTAEHWARQDIR TIEDSKLRALLTLCAVMTRKFSKSQLSLLCETHLRREGLGQDQAEPVLEVYQRLHSDK GGSFEAALWQQWDRQSLIMFITAFLNIALQLPCESSAVVVSGLRTLVPQSDNEEASTN PGTCSWSDEGTP" regulatory 9724..9734 /regulatory_class="polyA_signal_sequence" /gene="VP30" /note="putative" gene 9879..11512 /gene="VP24" /note="putative" mRNA 9879..11512 /gene="VP24" /product="VP24" regulatory 9879..9890 /regulatory_class="other" /gene="VP24" /note="putative transcription start signal" CDS 10339..11094 /gene="VP24" /note="membrane-associated protein" /codon_start=1 /product="VP24" /protein_id="AIE11903.1" /translation="MAKATGRYNLISPKKDLEKGVVLSDLCNFLVSQTIQGWKVYWAG IEFDVTHKGMALLHRLKTNDFAPAWSMTRNLFPHLFQNPNSTIESPLWALRVILAAGI QDQLIDQSLIEPLAGALGLISDWLLTTNTNHFNMRTQRVKEQLSLKMLSLIRSNILKF INKLDALHVVNYNGLLSSIEIGTQNHTIIITRTNMGFLVELQEPDKSAMNRKKPGPAK FSLLHESTLKAFTQGSSTRMQSLILEFNSSLAI" regulatory 11479..11490 /regulatory_class="polyA_signal_sequence" /gene="VP24" /note="putative" gene 11495..18276 /gene="L" mRNA 11495..18276 /gene="L" /product="polymerase" regulatory 11495..11506 /regulatory_class="other" /gene="L" /note="putative transcription start signal" regulatory 11502..11512 /regulatory_class="polyA_signal_sequence" /gene="VP24" /note="putative" CDS 11575..18213 /gene="L" /note="involved in synthesis of viral RNAs and transcriptional RNA editing" /codon_start=1 /product="polymerase" /protein_id="AIE11904.1" /translation="MATQHTQYPDARLSSPIVLDQCDLVTRACGLYSSYSLNPQLRNC KLPKHIYRLKYDVTVTKFLSDVPVATLPIDFIVPILLKALSGNGFCPVEPRCQQFLDE IIKYTMQDALFLKYYLKNVGAQEDCVDDHFQEKILSSIQGNEFLHQMFFWYDLAILTR RGRLNRGNSRSTWFVHDDLIDILGYGDYVFWKIPISLLPLNTQGIPHAAMDWYQTSVF KEAVQGHTHIVSVSTADVLIMCKDLITCRFNTTLISKIAEVEDPVCSDYPNFKIVSML YQSGDYLLSILGSDGYKIIKFLEPLCLAKIQLCSKYTERKGRFLTQMHLAVNHTLEEI TEIRALKPSQAHKIREFHRTLIRLEMTPQQLCELFSIQKHWGHPVLHSETAIQKVKKH ATVLKALRPIVIFETYCVFKYSIAKHYFDSQGSWYSVTSDRNLTPGLNSYIKRNQFPP LPMIKELLWEFYHLDHPPLFSTKIISDLSIFIKDRATAVERTCWDAVFEPNVLGYNPP HKFSTKRVPEQFLEQENFSIENVLSYAQKLEYLLPQYRNFSFSLKEKELNVGRTFGKL PYPTRNVQTLCEALLADGLAKAFPSNMMVVTEREQKESLLHQASWHHTSDDFGEHATV RGSSFVTDLEKYNLAFRYEFTAPFIEYCNRCYGVKNVFNWMHYTIPQCYMHVSDYYNP PHNLTLENRNNPPEGPSSYRGHMGGIEGLQQKLWTSISCAQISLVEIKTGFKLRSAVM GDNQCITVLSVFPLETDAGEQEQSAEDNAARVAASLAKVTSACGIFLKPDETFVHSGF IYFGKKQYLNGVQLPQSLKTATRMAPLSDAIFDDLQGTLASIGTAFERSISETRHIFP CRITAAFHTFFSVRILQYHHLGFNKGFDLGQLTLGKPLDFGTISLALAVPQVLGGLSF LNPEKCFYRNLGDPVTSGLFQLKTYLRMIEMDDLFLPLIAKNPGNCTAIDFVLNPSGL NVPGSQDLTSFLRQIVRRTITLSAKNKLINTLFHASADFEDEMVCKWLLSSTPVMSRF AADIFSRTPSGKRLQILGYLEGTRTLLASKIINNNTETPVLDRLRKITLQRWSLWFSY LDHCDNILAEALTQITCTVDLAQILREYSWAHILEGRPLIGATLPCMIEQFKVVWLKP YEQCPQCSNAKQPGGKPFVSVAVKKHIVSAWPNASRISWTIGDGIPYIGSRTEDKIGQ PAIKPKCPSAALREAIELASRLTWVTQGSSNSDLLIKPFLEARVNLSVQEILQMTPSH YSGNIVHRYNDQYSPHSFMANRMSNSATRLIVSTNTLGEFSGGGQSARDSNIIFQNVI NYAVALFDIKFRNTEATDIQYNRAHLHLTKCCTREVPAQYLTYTSTLDLDLTRYRENE LIYDNNPLKGGLNCNISFDNPFFQGKQLNIIEDDLIRLPHLSGWELAKTIMQSIISDS NNSSTDPISSGETRSFTTHFLTYPKIGLLYSFGAFVSYYLGNTILRTKKLTLDNFLYY LTTQIHNLPHRSLRILKPTFKHASVMSRLMSIDPHFSIYIGGAAGDRGLSDAARLFLR TSISSFLTFVKEWIINRGTIVPLWIVYPLEGQNPTPVNNFLHQIVELLVHDSSRHQAF KTTINDHVHPHDNLVYTCKSTASNFFHASLAYWRSRHRNSNRKDLTRNSSTGSSTNNS DGHIKRSQEQTTRDPHDGTERSLVLQMSHEIKRTTIPQENTHQGPSFQSFLSDSACGT ANPKLNFDRSRHNVKSQDHNSASKREGHQIISHRLVLPFFTLSQGTRQLTSSNESQTQ DEISKYLRQLRSVIDTTVYCRFTGIVSSMHYKLDEVLWEIENFKSAVTLAEGEGAGAL LLIQKYQVKTLFFNTLATESSIESEIVSGMTTPRMLLPVMSKFHNDQIEIILNNSASQ ITDITNPTWFKDQRARLPRQVEVITMDAETTENINRSKLYEAVHKLILHHVDPSVLKA VVLKVFLSDTEGMLWLNDNLAPFFATGYLIKPITSSARSSEWYLCLTNFLSTTRKMPH QNHLSCKQVILTALQLQIQRSPYWLSHLTQYADCDLHLSYIRLGFPSLEKVLYHRYNL VDSKRGPLVSVTQHLAHLRAEIRELTNDYNQQRQSRTQTYHFIRTAKGRITKLVNDYL KFFLIVQALKHNGTWQAEFKKLPELISVCNRFYHIRDCNCEERFLVQTLYLHRMQDSE VKLIERLTGLLSLFPDGLYRFD" regulatory 18266..18276 /regulatory_class="polyA_signal_sequence" /gene="L" BASE COUNT 6050 a 4051 c 3752 g 5099 t ORIGIN 1 cacaaaaaga aagaagaatt tttaggatct tttgtgtgcg aataactatg aggaagatta 61 ataattttcc tctcattgaa atttatatcg gaatttaaat tgaaattgtt actgtaatca 121 tacctggttt gtttcagagc catatcacca agatagagaa caacctaggt ctccggaggg 181 ggcaagggca tcagtgtgct cagttgaaaa tcccttgtca acatctaggc cttatcacat 241 cacaagttcc gccttaaact ctgcagggtg atccaacaac cttaatagca acattattgt 301 taaaggacag cattagttca cagtcaaaca agcaagattg agaattaact ttgattttga 361 acctgaacac ccagaggact ggagactcaa caaccctaaa gcctggggta aaacattaga 421 aatagtttaa agacaaattg ctcggaatca caaaattccg agtatggatt ctcgtcctca 481 gaaagtctgg atgacgccga gtctcactga atctgacatg gattaccaca agatcttgac 541 agcaggtctg tccgttcaac aggggattgt tcggcaaaga gtcatcccag tgtatcaagt 601 aaacaatctt gaggaaattt gccaacttat catacaggcc tttgaagctg gtgttgattt 661 tcaagagagt gcggacagtt tccttctcat gctttgtctt catcatgcgt accaaggaga 721 ttacaaactt ttcttggaaa gtggcgcagt caagtatttg gaagggcacg ggttccgttt 781 tgaagtcaag aagtgtgatg gagtgaagcg ccttgaggaa ttgctgccag cagtatctag 841 tgggagaaac attaagagaa cacttgctgc catgccggaa gaggagacga ctgaagctaa 901 tgccggtcag ttcctctcct ttgcaagtct attccttccg aaattggtag taggagaaaa 961 ggcttgcctt gagaaggttc aaaggcaaat tcaagtacat gcagagcaag gactgataca 1021 atatccaaca gcttggcaat cagtaggaca catgatggtg attttccgtt tgatgcgaac 1081 aaattttttg atcaaatttc ttctaataca ccaagggatg cacatggttg ccggacatga 1141 tgccaacgat gctgtgattt caaattcagt ggctcaagct cgtttttcag gtctattgat 1201 tgtcaaaaca gtacttgatc atatcctaca aaagacagaa cgaggagttc gtctccatcc 1261 tcttgcaagg accgccaagg taaaaaatga ggtgaactcc ttcaaggctg cactcagctc 1321 cctggccaag catggagagt atgctccttt cgcccgactt ttgaaccttt ctggagtaaa 1381 taatcttgag catggtcttt tccctcaact gtcggcaatt gcactcggag tcgccacagc 1441 ccacgggagc accctcgcag gagtaaatgt tggagaacag tatcaacagc tcagagaggc 1501 agccactgag gctgagaagc aactccaaca atatgcggag tctcgtgaac ttgaccatct 1561 tggacttgat gatcaggaaa agaaaattct tatgaacttc catcagaaaa agaacgaaat 1621 cagcttccag caaacaaacg cgatggtaac tctaagaaaa gagcgcctgg ccaagctgac 1681 agaagctatc actgctgcat cactgcccaa aacaagtgga cattacgatg atgatgacga 1741 cattcccttt ccaggaccca tcaatgatga cgacaatcct ggccatcaag atgatgatcc 1801 gactgactca caggatacga ccattcccga tgtggtagtt gaccccgatg atggaggcta 1861 cggcgaatac caaagttact cggaaaacgg catgagtgca ccagatgact tggtcctatt 1921 cgatctagac gaggacgacg aggacaccaa gccagtgcct aacagatcga ccaagggtgg 1981 acaacagaaa aacagtcaaa agggccagca tacagagggc agacagacac aatccacgcc 2041 aactcaaaac gtcacaggcc ctcgcagaac aatccaccat gccagtgctc cactcacgga 2101 caatgacaga agaaacgaac cctccggctc aaccagccct cgcatgctga ccccaatcaa 2161 cgaagaggca gacccactgg acgatgccga cgacgagacg tctagccttc cgcccttaga 2221 gtcagatgat gaagaacagg acagggacgg aacttctaac cgcacaccca ctgtcgcccc 2281 accggctccc gtatacagag atcactccga aaagaaagaa ctcccgcaag atgaacaaca 2341 agatcaggac cacattcaag aggccaggaa ccaagacagt gacaacaccc agccagaaca 2401 ttcttttgag gagatgtatc gccacattct aagatcacag gggccatttg atgccgtttt 2461 gtattatcat atgatgaagg atgagcctgt agttttcagt accagtgatg gtaaagagta 2521 cacgtatccg gactcccttg aagaggaata tccaccatgg ctcactgaaa aagaggccat 2581 gaatgatgag aatagatttg ttacactgga tggtcaacaa ttttattggc cagtaatgaa 2641 tcacaggaat aaattcatgg caatcctgca acatcatcag tgaatgagca tgtaataatg 2701 ggatgattta atcgacaaat agctaacatt aaatagtcaa ggaacgcaaa caggaagaat 2761 ttttgatgtc taaggtgtga attattatca caataaaagt gattcttagt tttgaattta 2821 aagctagctt attattacta gccgtttttc aaagttcaat ttgagtctta atgcaaataa 2881 gcgttaagcc acagttatag ccataatggt aactcaatat cttagccagc gatttatcta 2941 aattaaatta cattatgctt ttataactta cctactagcc tgcccaacat ttacacgatc 3001 gttttataat taagaaaaaa ctaatgatga agattaaaac cttcatcatc cttacgtcaa 3061 ttgaattctc tagcactaga agcttattgt cttcaatgta aaagaaaagc tggcctaaca 3121 agatgacaac tagaacaaag ggcaggggcc atactgtggc cacgactcaa aacgacagaa 3181 tgccaggccc tgagctttcg ggctggatct ctgagcagct aatgaccgga aggattcctg 3241 taaacgacat cttctgtgat attgagaaca atccaggatt atgctacgca tcccaaatgc 3301 aacaaacgaa gccaaacccg aagatgcgca acagtcaaac ccaaacggac ccaatttgca 3361 atcatagttt tgaggaggta gtacaaacat tggcttcatt ggctactgtt gtgcaacaac 3421 aaaccatcgc atcagaatca ttagaacaac gcattacgag tcttgagaat ggtctaaagc 3481 cagtttatga tatggcaaaa acaatctcct cattgaacag ggtttgtgct gagatggttg 3541 caaaatatga tcttctggtg atgacaaccg gtcgggcaac agcaaccgct gcggcaactg 3601 aggcttattg ggctgaacat ggtcaaccac cacctggacc atcactttat gaagaaagtg 3661 cgattcgggg taagattgaa tctagagatg agactgtccc tcaaagtgtt agggaggcat 3721 tcaacaatct agacagtacc acttcactaa ctgaggaaaa ttttgggaaa cctgacattt 3781 cggcaaagga tttgagaaac attatgtatg atcacttgcc tggttttgga actgctttcc 3841 accaattagt acaagtgatt tgtaaattgg gaaaagatag caattcattg gacattattc 3901 atgctgagtt ccaggccagc ctggctgaag gagactcccc tcaatgtgcc ctaattcaaa 3961 ttacaaaaag agttccaatc ttccaagatg ctgctccacc tgtcatccac atccgctctc 4021 gaggtgacat tccccgagct tgccagaaga gcttgcgtcc agtcccacca tcacccaaga 4081 ttgatcgagg ttgggtatgt gtttttcagc ttcaagatgg taaaacactt ggactcaaaa 4141 tttgagccaa tctcttttcc ctccgaaaga ggcaactaat agcagaggct tcaactgctg 4201 aactataggg tatgttacat taatgataca cttgtgagta tcagccctag ataatataag 4261 tcaattaaac aaccaagata aaattgttca tatcccgcta gcagctttaa agataaatgt 4321 aataggagct atacctctga cagtattata attaattgtt attaagtaac ccaaaccaaa 4381 aatgatgaag attaagaaaa acctacctcg actgagagag tgttttttca ttaaccttca 4441 tcttgtaaac gttgagcaaa attgttaaaa atatgaggcg ggttatattg cctactgctc 4501 ctcctgaata tatggaggcc atataccctg ccaggtcaaa ttcaacaatt gctaggggtg 4561 gcaacagcaa tacaggcttc ctgacaccgg agtcagtcaa tggagacact ccatcgaatc 4621 cactcaggcc aattgctgat gacaccatcg accatgccag ccacacacca ggcagtgtgt 4681 catcagcatt catcctcgaa gctatggtga atgtcatatc gggccccaaa gtgctaatga 4741 agcaaattcc aatttggctt cctctaggtg tcgctgatca aaagacctac agctttgact 4801 caactacggc cgccatcatg cttgcttcat atactatcac ccatttcggc aaggcaacca 4861 atccgcttgt cagagtcaat cggctgggtc ctggaatccc ggatcacccc ctcaggctcc 4921 tgcgaattgg aaaccaggct ttcctccagg agttcgttct tccaccagtc caactacccc 4981 agtatttcac ctttgatttg acagcactca aactgatcac tcaaccactg cctgctgcaa 5041 catggaccga tgacactcca actggatcaa atggagcgtt gcgtccagga atttcatttc 5101 atccaaaact tcgccccatt cttttaccca acaaaagtgg gaagaagggg aacagtgccg 5161 atctaacatc tccggagaaa atccaagcaa taatgacttc actccaggac tttaagatcg 5221 ttccaattga tccaaccaaa aatatcatgg gtatcgaagt gccagaaact ctggtccaca 5281 agctgaccgg taagaaggtg acttccaaaa atggacaacc aatcatccct gttcttttgc 5341 caaagtacat tgggttggac ccggtggctc caggagacct caccatggta atcacacagg 5401 attgtgacac gtgtcattct cctgcaagtc ttccagctgt ggttgagaag taattgcaat 5461 aattgactca gatccagttt tacagaatct tctcagggat agtgataaca tctttttaat 5521 aatccgtcta ctagaagaga tacttctaat tgatcaatat actaaaggtg ctttacacca 5581 ttgtctcttt tctctcctaa atgtagagct taacaaaaga ctcataatat acctgttttt 5641 aaaagattga ttgatgaaag atcatgacta ataacattac aaacaatcct actataatca 5701 atacggtgat tcaaatgtca atctttctca ttgcacatac tctttgtcct tatcctcaaa 5761 ttgcctacat gcttacatct gaggacagcc agtgtgactt ggattggaga tgtggaggaa 5821 aaatcggggc ccatttctaa gttgttcaca atctaagtac agacattgct cttctaatta 5881 agaaaaaatc ggcgatgaag attaagccga cagtgagcgt aatcttcatc tctcttagat 5941 tatttgtctt ccagagtagg ggtcatcagg tccttttcaa ttggataacc aaaataagct 6001 tcactagaag gatattgtga ggcgacaaca caatgggtgt tacaggaata ttgcagttac 6061 ctcgtgatcg attcaagagg acatcattct ttctttgggt aattatcctt ttccaaagaa 6121 cattttccat cccgcttgga gttatccaca atagtacatt acaggttagt gatgtcgaca 6181 aactagtttg tcgtgacaaa ctgtcatcca caaatcaatt gagatcagtt ggactgaatc 6241 tcgaggggaa tggagtggca actgacgtgc catctgtgac taaaagatgg ggcttcaggt 6301 ccggtgtccc accaaaggtg gtcaattatg aagctggtga atgggctgaa aactgctaca 6361 atcttgaaat caaaaaacct gacgggagtg agtgtctacc agcagcgcca gacgggattc 6421 ggggcttccc ccggtgccgg tatgtgcaca aagtatcagg aacgggacca tgtgccggag 6481 actttgcctt ccacaaagag ggtgctttct tcctgtatga tcgacttgct tccacagtta 6541 tctaccgagg aacgactttc gctgaaggtg tcgttgcatt tctgatactg ccccaagcta 6601 agaaggactt cttcagctca caccccttga gagagccggt caatgcaacg gaggacccgt 6661 cgagtggcta ttattctacc acaattagat atcaggctac cggttttgga actaatgaga 6721 cagagtactt gttcgaggtt gacaatttga cctacgtcca acttgaatca agattcacac 6781 cacagtttct gctccagctg aatgagacaa tatatgcaag tgggaagagg agcaacacca 6841 cgggaaaact aatttggaag gtcaaccccg aaattgatac aacaatcggg gagtgggcct 6901 tctgggaaac taaaaaaacc tcactagaaa aattcgcagt gaagagttgt ctttcacagc 6961 tgtatcaaac ggacccaaaa acatcagtgg tcagagtccg gcgcgaactt cttccgaccc 7021 agagaccaac acaacaaatg aagaccacaa aatcatggct tcagaaaatt cctctgcaat 7081 ggttcaagtg cacagtcaag gaaggaaagc tgcagtgtcg catctgacaa cccttgccac 7141 aatctccacg agtcctcaac ctcccacaac caaaacaggt ccggacaaca gcacccataa 7201 tacacccgtg tataaacttg acatctctga ggcaactcaa gttggacaac atcaccgtag 7261 agcagacaac gacagcacag cctccgacac tccccccgcc acgaccgcag ccggaccctt 7321 aaaagcagag aacaccaaca cgagtaagag cgctgactcc ctggacctcg ccaccacgac 7381 aagcccccaa aactacagcg agactgctgg caacaacaac actcatcacc aagataccgg 7441 agaagagagt gccagcagcg ggaagctagg cttaattacc aatactattg ctggagtagc 7501 aggactgatc acaggcggga gaaggactcg aagagaagta attgtcaatg ctcaacccaa 7561 atgcaacccc aatttacatt actggactac tcaggatgaa ggtgctgcaa tcggattggc 7621 ctggatacca tatttcgggc cagcagccga aggaatttac acagaggggc taatgcacaa 7681 ccaagatggt ttaatctgtg ggttgaggca gctggccaac gaaacgactc aagctctcca 7741 actgttcctg agagccacaa ctgagctgcg aaccttttca atcctcaacc gtaaggcaat 7801 tgacttcctg ctgcagcgat ggggtggcac atgccacatt ttgggaccgg actgctgtat 7861 cgaaccacat gattggacca agaacataac agacaaaatt gatcagatta ttcatgattt 7921 tgttgataaa acccttccgg accaggggga caatgacaat tggtggacag gatggagaca 7981 atggataccg gcaggtattg gagttacagg tgttataatt gcagttatcg ctttattctg 8041 tatatgcaaa tttgtctttt agtctttctt cagattgttt cacggcaaaa ctcaacctca 8101 aatcaatgaa actaggattt aattatatga atcacttgaa tctaagatta cttgacaaat 8161 gataacataa tacactggag cttcaaacat agccaatgtg attctaactc ctttaaactc 8221 acagttaatc ataaacaagg tttgacatca atctagctat atctttaaga atgataaact 8281 tgatgaagat taagaaaaag gtaatctttc gattatcttt agtcttcatc cttgattcta 8341 caatcatgac agttgtcttt aatgaaaaag gaaaaaagcc tttttattaa gttgtaataa 8401 tcagatctgc aaaccggtag aatttagttg taacctaaca cacacaaagc attggtaaaa 8461 aagtcaatag aaatttaaac agtgagtgca gacaactctt aaatggaagc ttcatatgag 8521 agaggacgcc cccgagctgc cagacagcat tcaagggatg gacacgacca ccatgttcga 8581 gcacgatcat catccagaga gaattatcga ggtgagtacc gtcaatcaag gagcgcctca 8641 caagtgcgcg ttcctactgt atttcataag aagagagttg aaccattaac agttcctcca 8701 gcacctaaag acatatgtcc gaccttgaaa aaaggatttt tgtgtgacag tagtttttgc 8761 aaaaaagacc accagttaga aagtttaact gatagggaat tactcctact aatcgcccgt 8821 aagacttgtg gatcagtaga acaacaatta aatataactg cacccaagga ctcgcgctta 8881 gcaaatccaa cggctgatga tttccagcaa gaggaaggtc ccaaaattac cttgttgaca 8941 ctgatcaaga cggcagaaca ctgggcgaga caagacatcc gaaccataga ggattccaaa 9001 ttaagggcat tgttaactct atgtgctgtg atgacgagga aattctcaaa atcccagctg 9061 agtcttttgt gtgagacaca cctaaggcgc gaagggcttg ggcaagatca ggcagaaccc 9121 gttctcgaag tatatcaacg attacacagt gataaaggag gcagttttga agctgcacta 9181 tggcaacaat gggaccgaca atccctaatt atgtttatca ctgcattctt gaatatcgct 9241 ctccagttac cgtgtgaaag ttctgctgtc gttgtttcag ggttaagaac attggttcct 9301 caatcagata atgaggaagc ttcaaccaac ccggggacat gctcatggtc tgatgagggt 9361 accccttaat aaggctgact aaaacactat ataaccttct acttgatcac aatactccgt 9421 atacctatca tcatatattt aatcaagacg atatccttta aaacttattc agtactataa 9481 tcactctcat ttcaaattga taagatatgc ataattgcct taatatataa agaggtatga 9541 tataacccaa acattgacca aagaaaatca taatctcgta tcgctcgcaa tataacctgc 9601 caagcatacc tcttgcacaa agtgattctt gtacacaaat aatgtttgac tctacaggag 9661 gtagcaacga tccatctcat caaaaaataa gtattttatg atttactaat gatctcttaa 9721 aatattaaga aaaactgacg gaacataaat tctttctgct tcaagttgtg gaggaggtct 9781 atggtattcg ctattgttat attacaatca ataacaagct tgtaaaaata ttgttcttgt 9841 ttcaggaggt atattgtgac cggaaaagct aaactaatga tgaagattaa tgcggaggtc 9901 tgatgagaat aaaccttatt attcagatta ggccccaaga ggcattcttc atctcctttt 9961 agcaaaatac tatttcagga tagtccagct agtgacacgt cttttagctg tataccagtt 10021 gcccctgaga tacgccacaa aagtgtctct gagctaaagt ggtctgtaca catctcatac 10081 attgtattag gggcaataat atctaattga acttagccat ttaaaattta gtgcataaat 10141 ctgggctaac tccaccaggt caactccatt ggctgaaaag aagcccacct acaacgaaca 10201 ttactttgag cgccctcaca attaaaaaat aagagcgtcg ttccaacaat cgagcgcaag 10261 gttacaaggt tgaactgaga gtgtctagac aacaaaatat cgatactcca gacaccaagc 10321 aagacctgag aaaaaaccat ggccaaagct acgggacgat acaatctaat atcgcccaaa 10381 aaggacctgg agaaaggggt tgtcttaagc gacctctgta acttcttagt tagtcaaact 10441 attcaagggt ggaaagttta ttgggctggt attgagtttg atgtgactca caaaggaatg 10501 gccctattgc atagactgaa aactaatgac tttgcccctg catggtcaat gacaaggaac 10561 ctatttcccc atttatttca aaatccgaat tccactattg aatcaccgct gtgggcactg 10621 agagtcatcc ttgcagcagg gatacaggac cagttaattg accagtcttt gattgaaccc 10681 ttagcaggag cccttggtct gatctctgat tggctgctaa caaccaacac taaccatttc 10741 aacatgcgaa cacaacgtgt caaggaacaa ttgagcctaa aaatgctgtc gttgattcga 10801 tccaatattc tcaagtttat taacaaattg gatgctctac atgtcgtgaa ctacaatgga 10861 ttattgagca gtattgaaat tggaactcaa aatcatacaa tcatcataac tcgaactaac 10921 atgggttttc tggtggagct ccaagaaccc gacaaatcgg caatgaaccg caagaagcct 10981 gggccggcga aattttccct ccttcatgag tccacactga aagcatttac acaagggtcc 11041 tcgacacgaa tgcaaagttt aattcttgaa ttcaatagct ctcttgctat ctaactaaga 11101 tggaatactt catattgggc taactcatat atgctgactc aatagttaac ttgacatctc 11161 tgccttcata atcagatata taagcataat aaataaatac tcatatttct tgataatttg 11221 tttaaccaca gataaatcct cactgtaagc cagcttccaa gttgacaccc ttacaaaaac 11281 caggactcag aatccctcaa ataagagatt ccaagacaac atcatagaat tgctttatta 11341 tattaataag cattttatca ctagaaatcc aatatacgaa atggttaatt gtaactaaac 11401 ccgcaggtca tgtgtgttag gtttcacaaa ttatatatat tactaactcc atactcgtaa 11461 ctaacattag ataagtaggt taagaaaaaa gcttgaggaa gattaagaaa aactgcttat 11521 tgggtctttc cgtgttttag atgaagcagt tgacattctt cctcttgata ttaaatggct 11581 acacaacata cccaataccc agacgccagg ttatcatcac caattgtatt ggaccaatgt 11641 gaccttgtca ctagagcttg cgggttgtat tcatcatact cccttaatcc gcaactacgc 11701 aactgtaaac tcccgaaaca tatataccgt ttaaaatatg atgtaactgt taccaagttc 11761 ttaagtgatg taccagtggc gacattgccc atagatttca tagtcccaat tcttctcaag 11821 gcactatcag gcaatgggtt ctgtcctgtt gagccgcggt gccaacagtt cttagatgaa 11881 attattaagt acacaatgca agatgctctc ttcctgaaat attatctcaa aaatgtgggt 11941 gctcaagaag actgtgttga tgaccacttt caagaaaaaa tcttatcttc aattcagggc 12001 aatgaatttt tacatcaaat gtttttctgg tatgacctgg ctattttaac tcgaaggggt 12061 agattaaatc gaggaaactc tagatcaacg tggtttgttc atgatgattt aatagacatc 12121 ttaggctatg gggactatgt tttttggaag atcccaattt cactgttacc actgaacaca 12181 caaggaatcc cccatgctgc tatggattgg tatcagacat cagtattcaa agaagcggtt 12241 caagggcata cacacattgt ttctgtttct actgccgatg tcttgataat gtgcaaagat 12301 ttaattacat gtcgattcaa cacaactcta atctcaaaaa tagcagaggt tgaggaccca 12361 gtttgctctg attatcccaa ttttaagatt gtgtctatgc tttaccagag cggagattac 12421 ttactctcca tattagggtc tgatgggtat aaaatcatta agtttctcga accattgtgc 12481 ttggctaaaa ttcaattgtg ctcaaagtac accgagagga agggccgatt cttaacacaa 12541 atgcatttag ctgtaaatca caccctggaa gaaattacag aaatacgtgc actaaagcct 12601 tcacaggctc acaagatccg tgaattccat agaacattga taaggctgga gatgacgcca 12661 caacaacttt gtgagctatt ttccatacaa aaacactggg ggcatcctgt gctacatagt 12721 gaaacagcaa tccaaaaagt taaaaaacat gctacggtgc taaaagcatt acgccctatc 12781 gtgattttcg agacatattg tgtttttaaa tatagcattg caaaacatta ttttgatagt 12841 caaggatctt ggtacagtgt tacctcagat agaaatctaa caccaggtct taattcttat 12901 atcaaaagaa atcaattccc tccgttgcca atgattaaag aactgctatg ggaattttac 12961 caccttgacc atcctccact tttctcaacc aaaattatta gtgacttaag tatttttata 13021 aaagacagag ctactgcagt agaaaggaca tgctgggatg cagtattcga gcctaatgtt 13081 ctgggatata atccacctca caaattcagt accaaacgtg taccggaaca atttttagag 13141 caagaaaact tttctattga gaatgttctt tcctacgcgc aaaaactcga gtatctacta 13201 ccacaatatc ggaatttttc tttctcattg aaagagaaag agttgaatgt aggtagaact 13261 ttcggaaaat tgccttatcc gactcgcaat gttcaaacac tttgtgaagc tctgttagct 13321 gatggtcttg ctaaagcatt tcctagcaat atgatggtag ttacggaacg tgaacaaaaa 13381 gaaagcttat tgcatcaagc atcatggcac cacacaagtg atgatttcgg tgagcatgcc 13441 acagttagag ggagtagctt tgtaactgat ttagagaaat acaatcttgc atttaggtat 13501 gagtttacag caccttttat agaatattgc aaccgttgct atggtgttaa gaatgttttt 13561 aattggatgc attatacaat cccacagtgt tatatgcatg tcagtgatta ttataatcca 13621 ccgcataacc tcacactgga aaatcgaaac aacccccctg aagggcctag ttcatacagg 13681 ggtcatatgg gagggattga aggactgcaa caaaaactct ggacaagtat ttcatgtgct 13741 caaatttctt tagttgaaat taagactggt tttaagttgc gctcagctgt gatgggtgac 13801 aatcagtgca ttaccgtttt atcagtcttc cccttagaga ctgatgcagg cgagcaggaa 13861 cagagcgccg aggacaatgc agcgagggtg gccgccagcc tagcaaaagt tacaagtgcc 13921 tgtggaatct ttttaaaacc tgatgaaaca tttgtacatt caggttttat ctattttgga 13981 aaaaaacaat atttgaatgg ggtccaattg cctcagtccc ttaaaacggc tacaagaatg 14041 gcaccattgt ctgatgcaat ttttgatgat cttcaaggga ccctggctag tataggtact 14101 gcttttgagc gatccatctc tgagacacga catatctttc cttgcagaat aaccgcagct 14161 ttccatacgt tcttttcggt gagaatcttg caatatcatc acctcggatt taataaaggt 14221 tttgaccttg gacagttaac actcggcaaa cctctggatt tcggaacaat atcattggca 14281 ctagcggtac cgcaggtgct tggagggtta tccttcttga atcctgagaa atgtttctac 14341 cggaatctag gagatccagt tacctcaggt ttattccagt taaaaactta tctccgaatg 14401 attgagatgg atgatttatt cttaccttta attgcgaaga accctgggaa ctgcactgcc 14461 attgactttg tgctaaatcc tagcggatta aatgttcctg ggtcgcaaga cttaacttca 14521 tttctgcgcc agattgtacg taggactatc accctaagtg cgaaaaacaa acttattaat 14581 accttatttc atgcatcagc tgacttcgaa gacgaaatgg tttgtaagtg gctcttatca 14641 tcaactcctg ttatgagtcg tttcgcagcc gatatatttt cacgcacgcc gagcgggaag 14701 cgattgcaaa ttctaggata cttggaagga acacgcacat tattagcctc taagatcatc 14761 aacaataata cagagacgcc ggttttggac agactgagga agataacatt gcaaaggtgg 14821 agtctatggt ttagttatct tgatcattgt gataatatcc tggcggaggc tttaacccaa 14881 ataacttgca cagttgattt agcacagatc ctgagggaat attcatgggc acatatttta 14941 gaggggagac ctcttattgg agccacactc ccatgtatga ttgagcaatt caaagtggtt 15001 tggctgaaac cctacgaaca atgtccgcag tgttcaaatg ccaagcaacc tggtgggaaa 15061 ccattcgtgt cagtagcagt caagaaacat attgttagtg catggccaaa tgcatcccga 15121 ataagctgga ctatcgggga tggaatccca tacattggat caaggacaga agataagata 15181 gggcaacctg ctattaaacc aaaatgtcct tccgcagcct taagagaggc cattgaattg 15241 gcgtcccgtt taacatgggt aactcaaggc agttcgaaca gtgacttgct aataaaacca 15301 tttttggaag cacgagtaaa tttaagtgtt caagaaatac ttcaaatgac cccttcacat 15361 tactcgggaa atattgttca taggtacaac gatcaataca gtcctcattc tttcatggcc 15421 aatcgtatga gtaactcagc aacgcgattg attgtttcta caaacacttt aggtgagttt 15481 tcaggaggtg gccaatcggc acgcgacagc aatattattt tccagaatgt tataaattat 15541 gcagttgcac tgttcgatat taaatttaga aacactgagg ctacagatat ccagtataat 15601 cgtgctcacc ttcatctaac taagtgttgc acccgggagg taccagctca gtacttaaca 15661 tacacatcta cattggattt agatttaaca agataccgag aaaatgaatt gatttatgac 15721 aataatcctc taaaaggagg actcaattgc aatatctcat ttgataaccc atttttccaa 15781 ggcaaacagc tgaacattat agaagatgac cttattcgac tgcctcactt atctggatgg 15841 gagctagcta agaccatcat gcaatcaatt atttcagata gcaataattc gtctacagac 15901 ccaattagca gtggagaaac aagatcattc actacccatt tcttaactta tcccaaaata 15961 ggacttctgt acagttttgg ggcctttgta agttattatc ttggcaatac aattcttcgg 16021 actaagaaat taacacttga caatttttta tattacttaa ctacccaaat tcataatcta 16081 ccacatcgct cattgcgaat acttaagcca acattcaaac atgcaagcgt tatgtcacga 16141 ttaatgagta ttgatcccca tttttctatt tacataggcg gtgctgcagg tgacagagga 16201 ctctcagatg cggccaggtt atttttgaga acgtccattt catcttttct tacatttgta 16261 aaggaatgga taattaatcg cggaacaatt gtccctttat ggatagtata tccattagag 16321 ggtcaaaatc caacacctgt taataatttc ctccatcaga tcgtagaact gctggtgcat 16381 gattcatcaa gacaccaggc ttttaaaact accataaatg atcatgtaca tcctcacgac 16441 aatcttgttt acacatgtaa gagtacagcc agcaatttct tccatgcgtc attggcgtac 16501 tggaggagca ggcacagaaa cagcaaccga aaagacttga caagaaactc ttcaactgga 16561 tcaagcacaa acaacagtga tggtcatatt aagagaagtc aagaacaaac caccagagat 16621 ccacatgatg gcactgaacg gagtctagtc ctgcaaatga gccatgaaat aaaaagaacg 16681 acaattccac aagagaacac gcaccagggt ccgtcgttcc agtcatttct aagtgactct 16741 gcttgcggta cagcaaaccc aaaactaaat ttcgatagat cgagacacaa tgtgaaatct 16801 caggatcata actcagcatc caagagggaa ggtcatcaaa taatctcaca tcgtctagtc 16861 ctacctttct ttacattatc tcaagggaca cgccaattaa cgtcatccaa tgagtcacaa 16921 acccaagatg agatatcaaa gtacttacgg caattgagat ccgtcattga taccacagtt 16981 tattgtaggt ttaccggtat agtctcgtcc atgcattaca aacttgatga ggtcctttgg 17041 gaaatagaga attttaagtc ggctgtgacg ctggcagagg gagaaggtgc tggtgcctta 17101 ctattgattc agaaatacca agttaagacc ttattcttca acacgctagc tactgagtcc 17161 agtatagagt cagaaatagt atcaggaatg actactccta ggatgcttct acctgttatg 17221 tcaaaattcc ataatgacca aattgagatt attcttaaca actcagcaag ccaaataaca 17281 gacataacaa atcctacttg gtttaaagac caaagagcaa ggctacctag gcaagtcgag 17341 gttataacca tggatgcaga gacgacagag aatataaaca gatcgaaatt gtacgaagct 17401 gtacataaat tgatcttaca ccatgttgat cccagcgtat tgaaagcagt ggtccttaaa 17461 gtctttctaa gtgataccga gggtatgtta tggctaaatg ataatctagc cccgtttttt 17521 gccactgggt atttaattaa gccaataacg tcaagtgcca ggtctagtga gtggtatctt 17581 tgtctgacga acttcttatc aactacacgt aagatgccac accaaaacca tctcagttgt 17641 aagcaggtaa tacttacggc attgcaactg caaattcaac ggagcccata ctggctaagt 17701 catttaactc agtatgctga ctgcgattta catttaagct atatccgcct tggttttcca 17761 tcattagaga aagtactata ccacaggtat aaccttgtcg attcaaaaag aggtccacta 17821 gtctctgtca ctcagcactt agcacatctt agggcagaga ttcgagaatt gaccaatgat 17881 tataatcaac agcgacaaag tcggactcaa acatatcact ttattcgtac tgcaaaagga 17941 cgaatcacaa aactagtcaa tgattattta aaattctttc ttattgtaca agcattaaaa 18001 cataatggga catggcaagc tgagtttaag aaattaccag agttgattag tgtgtgcaat 18061 aggttctatc atattagaga ttgtaattgt gaagaacgtt tcttagttca aaccttatat 18121 ttacatagaa tgcaggattc tgaagttaag cttatcgaaa ggctgacagg gcttctgagt 18181 ttatttccag atggtctcta caggttcgat tgaataaccg tgcatagtat tttgatactt 18241 gtaaaggttg gttatcaaca tacagattat aaaaaactca taaattgctc tcatacatca 18301 tcttgatctg atttcaataa ataactattt agataacgaa aggagtcctt acattataca 18361 ctatatttgg cctctctccc tgcgtgataa tcaaaaaatt cacaatacag catgtgtgac 18421 atattactgc tgcaatgagt ctaacgcaac ataataaact ccgcactctt tataattaag 18481 ctttaacgat aggtctgggc tcatattgtt attgatatag taatgttgta tcaatatctt 18541 gccagatgga atagtgcttt ggttgataac acgacttctt aaaacaaaac tgatctttaa 18601 gattaagttt tttataattg tcattgcttt aatttgtcga tttaaaaatg gtgatagcct 18661 taatctttgt gtaaaataag agattaggtg taataacttt aacatttttg tctagtaagc 18721 tactattcca ttcagaatga taaaattaaa agaaaagaca tgactgtaaa atcagaaata 18781 ccttctttac aatatagcag actagataat aatcttcgtg ttaatgataa ttaaggcatt 18841 gaccacgctc atcagaaggc tcactagaat aaacgttgca aaaaggatcc ctggaaaaat 18901 ggtcgcacac aaaaatttaa aaataaatct atttcttctt ttttgtgtgt cc //