LOCUS       JH169855              358119 bp    DNA     linear   CON 14-MAR-2015
DEFINITION  Heterocephalus glaber unplaced genomic scaffold scaffold3564, whole
            genome shotgun sequence.
ACCESSION   JH169855 AFSB01000000
VERSION     JH169855.1
DBLINK      BioProject: PRJNA68323
            BioSample: SAMN00217190
KEYWORDS    WGS.
SOURCE      Heterocephalus glaber (naked mole-rat)
  ORGANISM  Heterocephalus glaber
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Hystricomorpha; Bathyergidae; Heterocephalus.
REFERENCE   1  (bases 1 to 358119)
  AUTHORS   Kim,E.B., Fang,X., Fushan,A.A., Huang,Z., Lobanov,A.V., Han,L.,
            Marino,S.M., Sun,X., Turanov,A.A., Yang,P., Yim,S.H., Zhao,X.,
            Kasaikina,M.V., Stoletzki,N., Peng,C., Polak,P., Xiong,Z.,
            Kiezun,A., Zhu,Y., Chen,Y., Kryukov,G.V., Zhang,Q., Peshkin,L.,
            Yang,L., Bronson,R.T., Buffenstein,R., Wang,B., Han,C., Li,Q.,
            Chen,L., Zhao,W., Sunyaev,S.R., Park,T.J., Zhang,G., Wang,J. and
            Gladyshev,V.N.
  TITLE     Genome sequencing reveals insights into physiology and longevity of
            the naked mole rat
  JOURNAL   Nature 479 (7372), 223-227 (2011)
   PUBMED   21993625
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 358119)
  AUTHORS   Kim,E.B., Fang,X., Fushan,A., Huang,Z., Lobanov,A., Han,L.,
            Marino,S., Sun,X., Turanov,A., Yang,P., Yim,S.H., Zhao,X.,
            Kasaikina,M., Stoletzki,N., Peng,C., Polak,P., Xiong,Z., Kiezun,A.,
            Zhu,Y., Chen,Y., Kryukov,G., Zhang,Q., Peshkin,L., Yang,L.,
            Bronson,R., Wang,B., Han,C., Li,Q., Chen,L., Zhao,W., Sunyaev,S.,
            Park,T., Zhang,G., Wang,J. and Gladyshev,V.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUL-2011) Department of Science and Technology,
            Beijing Genomics Institute, Shenzhen, 2nd Office Building, Beishan
            Industrial Zone, Beishan Road, Yantian District, Shenzhen,
            Guangdong 518083, China
COMMENT     Source DNA is available from laboratory of Thomas Park at
            University of Illinois at Chicago.
            
            ##Genome-Assembly-Data-START##
            Assembly Method       :: SOAPdenovo v. 1.05
            Assembly Name         :: HetGla_1.0
            Genome Coverage       :: 90x
            Sequencing Technology :: Illumina HiSeq 2000
            ##Genome-Assembly-Data-END##
FEATURES             Location/Qualifiers
     source          1..358119
                     /organism="Heterocephalus glaber"
                     /mol_type="genomic DNA"
                     /submitter_seqid="scaffold3564"
                     /db_xref="taxon:10181"
                     /chromosome="Unknown"
                     /sex="male"
     assembly_gap    1205..2603
                     /estimated_length=1399
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    3688..3879
                     /estimated_length=192
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    4367..4694
                     /estimated_length=328
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    29529..29632
                     /estimated_length=104
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    65029..65058
                     /estimated_length=30
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    68031..68187
                     /estimated_length=157
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     gene            <68265..>101059
                     /locus_tag="GW7_14102"
     mRNA            join(<68265..68558,95172..95295,97785..97948,98547..98642,
                     101000..>101059)
                     /locus_tag="GW7_14102"
                     /product="14-3-3 protein theta"
     CDS             join(68265..68558,95172..95295,97785..97948,98547..98642,
                     101000..101059)
                     /locus_tag="GW7_14102"
                     /note="GO_function: GO:0019904 - protein domain specific
                     binding [Evidence IEA]"
                     /codon_start=1
                     /product="14-3-3 protein theta"
                     /protein_id="EHB07712.1"
                     /db_xref="InterPro:IPR000308"
                     /db_xref="UniProtKB/Swiss-Prot:Q5RFJ2"
                     /translation="MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLL
                     SVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLD
                     KYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEM
                     QPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIM
                     QLLRDNLTLWTSDSAGEECDAAEGAEN"
     assembly_gap    70877..70923
                     /estimated_length=47
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    88079..88528
                     /estimated_length=450
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     gene            <114431..>157251
                     /locus_tag="GW7_14103"
     mRNA            join(<114431..114527,125447..125579,132505..132635,
                     133598..133686,135892..136060,138308..138441,
                     140318..140407,142667..142780,144927..145071,
                     145173..145261,147383..147535,151211..151410,
                     152773..152876,153081..153215,153994..154124,
                     154620..154698,155223..155311,156500..156550,
                     156868..>157251)
                     /locus_tag="GW7_14103"
                     /product="Disintegrin and metalloproteinase
                     domain-containing protein 17"
     CDS             join(114431..114527,125447..125579,132505..132635,
                     133598..133686,135892..136060,138308..138441,
                     140318..140407,142667..142780,144927..145071,
                     145173..145261,147383..147535,151211..151410,
                     152773..152876,153081..153215,153994..154124,
                     154620..154698,155223..155311,156500..156550,
                     156868..157251)
                     /locus_tag="GW7_14103"
                     /note="GO_function: GO:0004222 - metalloendopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /product="Disintegrin and metalloproteinase
                     domain-containing protein 17"
                     /protein_id="EHB07713.1"
                     /db_xref="InterPro:IPR001590"
                     /db_xref="InterPro:IPR001762"
                     /db_xref="UniProtKB/Swiss-Prot:P78536"
                     /translation="MRQRLLFLASLVLLVLAPRPPDASGSGSHQRLERLDSLLSDYDI
                     LSLSSIQQHSVRKRDLQASAHLETLLTFSALKRHFKLYLTSSTERFSQNFKVMVVDGK
                     AESEYAVSWQDFFSGHVVGEPDSRVLAHIGDDDVTIRINTDGAEYNIEPLWRFVNDTK
                     DKRMLAYRSEDIKNVSRLQSPKVCGYVKVEDEELIPEGLIDREPPGEFVHRVKRRADP
                     DPMKNTCKLLVVADHRFYKYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYG
                     IQIEQIRILKSPQEVRPGERHYNMAKSYPHEEKDSWDVKMLLEQFSFDIAEEASKVCL
                     AHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGK
                     TILTKEADLVTTHELGHNFGAEHDPDALPECAPNEDQGGKYVMYPIAVSGDHENNKMF
                     SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTL
                     KPGVQCSDRNSPCCKNCQFETAQKRCQEAINATCKGVSYCTGNSSECPPPGNAEDDTV
                     CLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDPSGRCVPYVDAEQKNLFL
                     RKGKPCTVGFCDMNGKCEKRVQDMIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLL
                     FWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQ
                     PLPPGPVMLPMSAALKLEHQRMDTIQEDPTPTLTRTPTRTRTASHADEDGLDKDPFPT
                     SSTAAKSFEDLTDHPATRSEKAASFRLQRQSRVDSKETEC"
     assembly_gap    119115..119518
                     /estimated_length=404
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    158020..158220
                     /estimated_length=201
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     gene            complement(<158838..>167108)
                     /locus_tag="GW7_14104"
     mRNA            complement(join(<158838..159032,159933..160047,
                     160892..161075,163377..163516,164949..165001,
                     167028..>167108))
                     /locus_tag="GW7_14104"
                     /product="Isoamyl acetate-hydrolyzing esterase 1-like
                     protein"
     CDS             complement(join(158838..159032,159933..160047,
                     160892..161075,163377..163516,164949..165001,
                     167028..167108))
                     /locus_tag="GW7_14104"
                     /note="GO_function: GO:0016788 - hydrolase activity,
                     acting on ester bonds [Evidence IEA];
                     GO_process: GO:0006629 - lipid metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /product="Isoamyl acetate-hydrolyzing esterase 1-like
                     protein"
                     /protein_id="EHB07714.1"
                     /db_xref="InterPro:IPR001087"
                     /db_xref="InterPro:IPR013830"
                     /db_xref="UniProtKB/Swiss-Prot:Q3SZ16"
                     /translation="MALAPGAAGGIPLFWPRVLLFGDSITQFSFQQGGWGAALADRLV
                     RKCDVLNRGFSGYNTRWAKIILPRLVGSRDSPAVVTIFFGANDSSLRDENPRQHVPLE
                     EYTANLSAMVRYLHSVGVTESRVVLVTPPPLWEAAWEEECVAQGETRSGAWRNRRNSV
                     TGEYARACAQVAHDCGTDVLDLWTLMQKDDQDLSAYLSDGLHLSPEGNNFVFSHLWPL
                     VEKKVSGLPLLLPYWKDVAEANPECSLLGQGGHSSAT"
     gene            complement(<169870..>194680)
                     /locus_tag="GW7_14105"
     mRNA            complement(join(<169870..169995,171202..171298,
                     172179..172248,173699..173786,174918..175012,
                     176542..176640,178142..178250,180013..180165,
                     181472..181618,182749..182907,184064..184239,
                     185191..185341,186454..186543,187510..187687,
                     188419..188547,189570..189667,191040..191103,
                     194631..>194680))
                     /locus_tag="GW7_14105"
                     /product="Cleavage and polyadenylation specificity factor
                     subunit 3"
     CDS             complement(join(169870..169995,171202..171298,
                     172179..172248,173699..173786,174918..175012,
                     176542..176640,178142..178250,180013..180165,
                     181472..181618,182749..182907,184064..184239,
                     185191..185341,186454..186543,187510..187687,
                     188419..188547,189570..189667,191040..191103,
                     194631..194680))
                     /locus_tag="GW7_14105"
                     /note="GO_function: GO:0016787 - hydrolase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /product="Cleavage and polyadenylation specificity factor
                     subunit 3"
                     /protein_id="EHB07715.1"
                     /db_xref="InterPro:IPR001279"
                     /db_xref="InterPro:IPR011108"
                     /db_xref="UniProtKB/Swiss-Prot:P79101"
                     /translation="MSAIPAEESDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIH
                     PGLEGMDALPYIDLIDPAEIDLLLISHFHLDHCGALPWFLQKTSFKGRTFMTHATKAI
                     YRWLLSDYVKVSNISADDMLYTETDLEESMDKIETINFHEVKEVAGIKFWCYHAGHVL
                     GAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIKPDILIIESTYGTHIHEKREER
                     EARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYWQNHPELHDIPIYYASSLAK
                     KCMAVYQTYVHAMNDKIRKQININNPFVFKHISNLKSMDHFDDIGPSVVMASPGMMQS
                     GLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIMSEPEEIATMSGQKLPLKMSVDYIS
                     FSAHTDYQQTSEFIRALKPPHVILVHGEQNEMARLKAALIREYEDNDEVHIEVHNPRN
                     TEAVTLNFRGEKLAKVMGFLADKKPEQGQRVSGILVKRNFNYHILSPCDLSNYTDLAM
                     STVKQTQAIPYTGPFHLLSYQLQKLTGDVEELEIQEKPALKVFKNITIILEPGMVILE
                     WLANPSNDMYADTVTTVILEVQSNPKIRKSVAQKVSKKLETHMYSKRLETMLQDIFGE
                     DCVSMKDSSVLSVTVDGKTANVSLETRSVECEEGSEDDESLREMVELAAQRLYDALTP
                     CAEAEPRDLP"
     gene            <199131..>205225
                     /locus_tag="GW7_14106"
     mRNA            join(<199131..199202,200328..200406,201548..201684,
                     203960..204052,204796..204945,205154..>205225)
                     /locus_tag="GW7_14106"
                     /product="Integrin beta-1-binding protein 1"
     CDS             join(199131..199202,200328..200406,201548..201684,
                     203960..204052,204796..204945,205154..205225)
                     /locus_tag="GW7_14106"
                     /codon_start=1
                     /product="Integrin beta-1-binding protein 1"
                     /protein_id="EHB07716.1"
                     /db_xref="InterPro:IPR006020"
                     /db_xref="InterPro:IPR019517"
                     /db_xref="UniProtKB/Swiss-Prot:Q3ZBM4"
                     /translation="MFRKGKKRHSSSSSQSSEISTKSKSVDSSLGGLSRSSTVASLDT
                     DSTKSSGQSNNNSDTCAEFRIKYVGAIEKLKLSEGKSLEGPLDLINYIDVAQQDGKLP
                     FVPLEEEYIMGVSKYGIKVSTLDQYDVLHRHALHLIIRMVCYDDGLGAGKSSLALKTT
                     DASDKEYSLWVYQCSSLEQAQAICKVLSTAFDSVLTSEKS"
     assembly_gap    206167..209773
                     /estimated_length=3607
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     gene            complement(<211825..>334729)
                     /locus_tag="GW7_14107"
     mRNA            complement(join(<211825..211899,212474..212596,
                     212919..212989,213447..213496,216060..216219,
                     218230..218364,220716..220785,222716..222829,
                     223889..223956,225018..225133,225979..226064,
                     227127..227316,232485..232579,237033..237166,
                     237571..237645,239524..239690,239770..239818,
                     242504..242591,247756..247825,247922..248025,
                     252366..252452,252711..252786,277839..277924,
                     280256..280385,282702..282751,284108..284182,
                     298290..298435,312720..312792,320085..320238,
                     334653..>334729))
                     /locus_tag="GW7_14107"
                     /product="Arf-GAP with SH3 domain, ANK repeat and PH
                     domain-containing protein 2"
     CDS             complement(join(211825..211899,212474..212596,
                     212919..212989,213447..213496,216060..216219,
                     218230..218364,220716..220785,222716..222829,
                     223889..223956,225018..225133,225979..226064,
                     227127..227316,232485..232579,237033..237166,
                     237571..237645,239524..239690,239770..239818,
                     242504..242591,247756..247825,247922..248025,
                     252366..252452,252711..252786,277839..277924,
                     280256..280385,282702..282751,284108..284182,
                     298290..298435,312720..312792,320085..320238,
                     334653..334729))
                     /locus_tag="GW7_14107"
                     /note="GO_function: GO:0008060 - ARF GTPase activator
                     activity [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_process: GO:0032312 - regulation of ARF GTPase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /product="Arf-GAP with SH3 domain, ANK repeat and PH
                     domain-containing protein 2"
                     /protein_id="EHB07717.1"
                     /db_xref="InterPro:IPR001164"
                     /db_xref="InterPro:IPR001452"
                     /db_xref="InterPro:IPR001849"
                     /db_xref="InterPro:IPR002110"
                     /db_xref="InterPro:IPR020683"
                     /db_xref="UniProtKB/Swiss-Prot:Q7SIG6"
                     /translation="MGPHLLCPCSLVVDAVEGTVISSLKLDCDQGHLLQVDEAGQELI
                     LWLLTELLCIAVCKQHCTPGRGFVPLSNPMVLTALDVDRMALYKMKKSVKAINISGLA
                     HVENEEQYTQALEKFGSNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISF
                     PLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISGAEI
                     AEEMEKERRLFQLQMCEYLLKVDEIKTKKGVDLLQNLIKYFHAQCNFFQDGLKAVESL
                     KPSIEMLSTDLHTIKQAQDEERKQLIQLRDILKSSVQVEQKEDSQLRQSTAYSLHQPQ
                     GNKEHGMERNGNLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVK
                     TNPEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDSTGENNI
                     VQELTKEIISDVQKMTGNDVCCDCGAPVLSTAHHKQIVRLAVAFSVHSLCVSDPTWLS
                     TNLGILTCIECSGIHRELGVHYSRIQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLP
                     AEDAVKPNPGSDMNARKDYIMAKYIERKYARKKHTDSAAKLHSLCESVKARAIFGLLQ
                     AYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTSKGS
                     TALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEELLTQALAGR
                     FISHVHVEYEWRLLHEDLDESDDDVDEKLQPSPNRREDRPVSFYQLGSSQLPPIQTAS
                     SASTPWKTNSVGVDGVSRQRSSSDPPAVHPPLPPLRVTSTNPLTSTPPPSVARPPPVL
                     EALSQPSKAPPPEASQSKALPPQPPSRPPQKKPVPGADRPTPLGSKGQPRGPEAAGAL
                     SNAAGLQPPAPMPRKSQVTKLKPKRVKALYNCVADNPDELTFSEGDVIIVDGEEDQEW
                     WIGHIDGDPSRKGAFPVSFVHFIAD"
     assembly_gap    215098..215277
                     /estimated_length=180
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    220654..220693
                     /estimated_length=40
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    228027..228042
                     /estimated_length=16
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    235837..235999
                     /estimated_length=163
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    238103..238116
                     /estimated_length=14
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    314924..314971
                     /estimated_length=48
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    315396..315459
                     /estimated_length=64
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    316707..316970
                     /estimated_length=264
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    317422..317562
                     /estimated_length=141
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    317966..318155
                     /estimated_length=190
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    318994..319554
                     /estimated_length=561
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    324936..324947
                     /estimated_length=12
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    331563..334116
                     /estimated_length=2554
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     assembly_gap    352229..352783
                     /estimated_length=555
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
CONTIG      join(AFSB01118564.1:1..1204,gap(1399),AFSB01118565.1:1..1084,
            gap(192),AFSB01118566.1:1..487,gap(328),AFSB01118567.1:1..24834,
            gap(104),AFSB01118568.1:1..35396,gap(30),AFSB01118569.1:1..2972,
            gap(157),AFSB01118570.1:1..2689,gap(47),AFSB01118571.1:1..17155,
            gap(450),AFSB01118572.1:1..30586,gap(404),AFSB01118573.1:1..38501,
            gap(201),AFSB01118574.1:1..47946,gap(3607),AFSB01118575.1:1..5324,
            gap(180),AFSB01118576.1:1..5376,gap(40),AFSB01118577.1:1..7333,
            gap(16),AFSB01118578.1:1..7794,gap(163),AFSB01118579.1:1..2103,
            gap(14),AFSB01118580.1:1..76807,gap(48),AFSB01118581.1:1..424,
            gap(64),AFSB01118582.1:1..1247,gap(264),AFSB01118583.1:1..451,
            gap(141),AFSB01118584.1:1..403,gap(190),AFSB01118585.1:1..838,
            gap(561),AFSB01118586.1:1..5381,gap(12),AFSB01118587.1:1..6615,
            gap(2554),AFSB01118588.1:1..18112,gap(555),AFSB01118589.1:1..5336)
//