LOCUS AH002819 6266 bp DNA linear HUM 10-JUN-2016 DEFINITION Homo sapiens dihydrofolate reductase (EC 1.5.1.3) (DHFR) gene, complete cds. ACCESSION AH002819 J00138 J00139 K01612 K01613 K01614 M10235 VERSION AH002819.2 KEYWORDS dihydrofolate reductase; reductase. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 2215 to 2383; 5680 to 5849) AUTHORS Chen,M.J., Shimada,T., Moulton,A.D., Harrison,M. and Nienhuis,A.W. TITLE Intronless human dihydrofolate reductase genes are derived from processed RNA molecules JOURNAL Proc. Natl. Acad. Sci. U.S.A. 79 (23), 7435-7439 (1982) PUBMED 6961421 REFERENCE 2 (bases 1 to 6266) AUTHORS Chen,M.J., Shimada,T., Moulton,A.D., Cline,A., Humphries,R.K., Maizel,J. and Nienhuis,A.W. TITLE The functional human dihydrofolate reductase gene JOURNAL J. Biol. Chem. 259 (6), 3933-3943 (1984) PUBMED 6323448 REFERENCE 3 (bases 800 to 1325) AUTHORS Masters,J.N. and Attardi,G. TITLE Discrete human dihydrofolate reductase gene transcripts present in polysomal RNA map with their 5' ends several hundred nucleotides upstream of the main mRNA start site JOURNAL Mol. Cell. Biol. 5 (3), 493-500 (1985) PUBMED 2859520 COMMENT On or before Jun 10, 2016 this sequence version replaced K01612.1, K01613.1, J00138.1, K01614.1, J00139.1, AH002819.1. FEATURES Location/Qualifiers source 1..6266 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" prim_transcript 844..>1908 /note="DHFR mRNA (minor alt.)" prim_transcript 854..>1908 /note="DHFR mRNA (minor alt.)" prim_transcript 858..>1908 /note="DHFR mRNA (minor alt.)" prim_transcript 864..>1908 /note="DHFR mRNA (minor alt.)" prim_transcript 868..>1908 /note="DHFR mRNA (minor alt.)" prim_transcript 875..>1908 /note="DHFR mRNA (minor alt.)" prim_transcript 1252..>1908 /note="DHFR mRNA (major alt.)" gene 1323..2922 /gene="DHFR" CDS join(1323..1408,1772..1821,2009..2114,2234..2360, 2518..2633,2844..2922) /gene="DHFR" /note="dihydrofolate reductase (EC 1.5.1.3)" /codon_start=1 /protein_id="AAA58484.1" /translation="MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSV EGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTE QPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLL PEYPGVLSDVQEEKGIKYKFEVYEKND" exon <1323..1408 /gene="DHFR" /note="dihydrofolate reductase (EC 1.5.1.3)" /number=1 intron 1409..1771 /gene="DHFR" /note="DHFR intron A" exon 1772..1821 /gene="DHFR" /number=2 intron 1822..>1908 /gene="DHFR" /note="DHFR intron B" gap 1909..2008 /estimated_length=unknown exon 2009..2114 /gene="DHFR" /note="dihydrofolate reductase (EC 1.5.1.3) or '5q11.1-q13.2'" /number=3 prim_transcript <2009..>2114 /gene="DHFR" /note="DHFR mRNA" gap 2115..2214 /estimated_length=unknown prim_transcript <2215..>2391 /gene="DHFR" /note="DHFR mRNA" intron <2215..2233 /gene="DHFR" /note="DHFR intron C" exon 2234..2360 /gene="DHFR" intron 2361..>2391 /gene="DHFR" /note="DHFR intron D" gap 2392..2491 /estimated_length=unknown prim_transcript <2492..>2702 /gene="DHFR" /note="DHFR mRNA" intron <2492..2517 /gene="DHFR" /note="DHFR intron D" exon 2518..2633 /gene="DHFR" /number=5 intron 2634..>2702 /gene="DHFR" /note="DHFR intron E" gap 2703..2802 /estimated_length=unknown prim_transcript <2803..5779 /note="DHFR mRNA (alt.)" prim_transcript <2803..3258 /note="DHFR mRNA (alt.)" prim_transcript <2803..3009 /note="DHFR mRNA (alt.)" intron <2803..2843 /gene="DHFR" /note="DHFR intron E" exon 2844..>2922 /gene="DHFR" /note="dihydrofolate reductase (EC 1.5.1.3)" /number=6 BASE COUNT 1737 a 1274 c 1358 g 1497 t ORIGIN 1 bp upstream of first EcoRI site 5' to exon 1. 1 gaattcatga aaacgtagct cgtcctcaaa aaaaacagaa gaggagtaat cattttaagg 61 gagaaatata tacgaaagga acaagatttt gaagcaccca agctgccacc tacattaaaa 121 cacggtaggt ggctaaacac cagtcttcaa tgcccttcca cagcctcagt ctgaaaaata 181 ctgtgcaggt gacccaagtg aggggtcacc cttgggcttt tcctgtggca gtatctctgg 241 tttaaaaaca aacaaacgta cttattgcgt tgaaggacgg caacaggaag gactccatga 301 ttagtcacat ctataccatc ctaagaaact ttatccaccc aaactgtatt tcagacttta 361 taatctaaac tacaaaaagt gttcactggg gaactgcaca atatgactgc ttttaaccgt 421 agtgatttca aatattgagc catgctgttg cagtcttaaa aactggagac ctaagggcag 481 ctttcttcta gtcacccaat ccagcacttt tttaaaaaat cagtaaaact cttcgaccac 541 caaggaaaaa aaaaaaggat ggaggttaaa agacgcaccc cttgcccaca agccccctca 601 tcagaatggg agtcaggaga cctgagttcc tgtctcaggc ctgccattaa aaacctgcat 661 aacctttgcc tatctcctca aacggaagta ctaaaacctc agcgcttcac ccaatttgta 721 gccccggctg ggctcttccc accttcccct tcttcagccc gccccttcct cctccagccc 781 tatcatcggg cggagggtcc ccgcctccgc ccgccttacc cacaagcccc gcccccccag 841 ccccgatggc cctgcccagt cccagacaga acctactacg tgcggcggca gctggggcgg 901 gaaggcgggc gctgggggcg ctgcggccgc tgcagcgcag ggtccacctg gtcggctgca 961 cctgtggagg aggaggtgga tttcaggctt cccgtagact ggaagaatcg gctcaaaacc 1021 gcttgcctcg caggggctga gctggaggca gcgaggccgc ccgacgcagg cttccggcga 1081 gacatggcag ggcaaggatg gcagcccggc ggcagggccc ggcgaggagc gcgaacccgc 1141 ggccgcagtt cccaggcgtc tgcgggcgcg agcacgccgc gaccctgcgt gcgccggggc 1201 gggggggcgg ggcctcgcct gcacaaatag ggacgagggg gcggggcggc cacaatttcg 1261 cgccaaactt gaccgcgcgt tctgctgtaa cgagcgggct cggaggtcct cccgctgctg 1321 tcatggttgg ttcgctaaac tgcatcgtcg ctgtgtccca gaacatgggc atcggcaaga 1381 acggggacct gccctggcca ccgctcaggt atctgccggg ccggggcgat gggacccaaa 1441 cgggcgcagg ctgcccacgg tcggggtacc tgggcgggac gcgccggccg actcccggcg 1501 agaggatggg gccagacttg cggtctgcgc tggcaggaag ggtgggcccg actggattcc 1561 ccttttctgc tgcgcgggag gcccagttgc tgatttctgc ccggattctg ctgcccggtg 1621 aggtcttgcc ctgcggcgcc ctcgcccagg gcaaagtccc agccctggag aaaacacctc 1681 acccctaccc acagcgctcc gtttgtcagg tgccttagag ctcgagccca agggataatg 1741 tttcgagtaa cgctgtttct ctaacttgta ggaatgaatt cagatatttc cagagaatga 1801 ccacaacctc ttcagtagaa ggtaatgtgg gattaagtag ggtcttgctt gatgaagttt 1861 accagtgcaa atgttagtta aatggaaagt tttccgtgtt aatctgggnn nnnnnnnnnn 1921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1981 nnnnnnnnnn nnnnnnnnnn nnnnnnnngt aaacagaatc tggtgattat gggtaagaag 2041 acctggttct ccattcctga gaagaatcga cctttaaagg gtagaattaa tttagttctc 2101 agcagagaac tcaannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnattctt 2221 tttttaacct tagggaacct ccacaaggag ctcattttct ttccagaagt ctagatgatg 2281 ccttaaaact tactgaacaa ccagaattag caaataaagt agacatggtc tggatagttg 2341 gtggcagttc tgtttataag gtatgtgttg ttgttggaaa taaaaaccaa tnnnnnnnnn 2401 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2461 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn naaaactgat gatgttttat ttcaaaggaa 2521 gccatgaatc acccaggcca tcttaaacta tttgtgacaa ggatcatgca agactttgaa 2581 agtgacacgt tttttccaga aattgatttg gagaaatata aacttctgcc agagtaagta 2641 taaggttatt aattagtctg aagcactttg gatttcctgc ttaagactat agaaataaca 2701 tgnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2761 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntttaatgg acacataatt 2821 taattatata ttttttctta cagataccca ggtgttctct ctgatgtcca ggaggagaaa 2881 ggcattaagt acaaatttga agtatatgag aagaatgatt aatatgaagg tgttttctag 2941 tttaagttgt tccccctccc tctgaaaaaa gtatgtattt ttacattaga aaaggttttt 3001 tgttgacttt agatctataa ttatttctaa gcaactagtt tttattcccc actactcttg 3061 tctctatcag ataccattta tgagacattc ttgctataac taagtgcttc tccaagaccc 3121 caactgagtc cccagcacct gctacagtga gctgccattc cacacccatc acatgtggca 3181 ctcttgccag tccttgacat tgtcgggctt ttcacatgtt ggtaatattt attaaagatg 3241 aagatccaca tacccttcaa ctgagcagtt tcactagtgg aaataccaaa agcttcctac 3301 gtgtatatcc agaggtttgt agataaatgt tgccaccttg tttgtaacag tgaaaaattg 3361 aaaacaacct ggaagtccag tgatgggaaa atgagtatgt ttctgtctta gattggggaa 3421 cccaaagcag attgcaagac tgaaatttca gtgaaagcag tgtatttgct aggtcatacc 3481 agaaatcatc aattgaggta cggagaaact gaactgagaa ggtaagaaaa gcaatttaaa 3541 gtcagcgagc aggttctcat tgataacaag ctccatactg ctgagataca gggaaatgga 3601 ggggggaaag ctggagtatt gatcccgccc ccctccttgg ttgtcagctc cctgtcctgt 3661 gtgtgggcgg aacatagtcc agctgctcta tagcaagtct caggtgtttg cagtaagaag 3721 ctgctggcat gcacgggaac agtgaatgcc aaacacttaa agcaattcga tgtttaagta 3781 tgtaagttct ttttttttta gacagcgttt cgctcttgtt gcccaggcta gcatgcaatg 3841 gtgtgacctc ggcttactgc aacctccgcc ttcccagatt caagcgattc tcctgcctca 3901 ggctcccaag tagctaggac caggtgcgcg ccaccacgcc cggctaattt ttgtattttg 3961 tatttttagt agagatgggg tttcaccatg ttggtcaggc tagtctcgaa ctcgtgaccg 4021 caagcgattc acccacctca gcctcccaaa gtgctgggat taccggcttg agccaccaca 4081 cccggcacat cttcattctt tttatgtagt aaaaagtata aggccacaca tggtttattt 4141 gaagtatttt ataatttaaa aaaatacaga agcaggaaaa ccaattataa gttcaagtga 4201 gggatgatgg ttgcttgaac caaagggttg catgtagtaa gaaattgtga tttaagatat 4261 attttaaagt tataagtagc aggatattct gatggagttt gactttggtt ttgggcccag 4321 ggagtttcag atgcctttga gaaatgaatg aagtagagag aaaataaaag aaaaaccagc 4381 caggcacagt ggctcacacc tgtaatccca gcgctttggg aggctaaggc aggcagatca 4441 cttgagacca gcttgggcaa catggcaaag ccccatctct acaaaaaaca caaaaattag 4501 ctgggcattg tggcgcacac ctgtattccc atctagtcag gaagctgaga tggaagaatt 4561 aattgagccc acgagttcaa ggctgcagtg agtcgtgatt gtgccactgc actccagccg 4621 gggtgacaga agagaccttg tctcgaaaac gaatctgaaa acaatggaac catgccttca 4681 taattctaga aagttatttt caactgataa atctatattc acccaaataa tcaagggtga 4741 aggtaaaata atacattttt agacaagcaa agactcaggg gttacctcca tgtgcccttt 4801 ttagggaagc tgttggagaa aatactccag caaaatgaag gagtacacaa accagagaat 4861 gacatgaatc cagcaaatag gatccaacac aggcaatatt ccagctatgg agctagcttt 4921 aaaaaggaac agtaaaaata ttaatcggtt agctgggtgg aatggcccat gcctgtagtc 4981 ccagctactc aggaggctca gcagcaggac gacttgagcc caagagttcc agaccagcct 5041 ggccacctta gtgagatccc ttctcttaaa aataataact tattgccaga tttggggcat 5101 ttggaaagaa gttcattgaa gataaagcaa aagtaaaaaa aaaaaaaaaa aaaacaaggg 5161 gaaagggttg gttaggcaat cattctaggg cagaaagaag tacaggatag gaagagcata 5221 atacactgtt tttctcaaca aggagcagta tgtacacagt cataatgatg tgactgctta 5281 gcccctaaat atggtaacta ctctgggaca atatgggagg aaaagtgaag attgtgatgg 5341 tgtaagagct aatcctcatc tgtcatatcc agaaatcact atataatata taataatgaa 5401 atgactaagt tatgtgagga aaaaaacaga agacattgct aaaagagtta aaagtcattg 5461 ctctggagaa ttaggaggga tggggcaggg gactgttagg atgcattata aactgaaaag 5521 cctttttaaa attttatgta ttaatatatg cattcacttg aaaaactaaa aaaaaacaat 5581 aatttggaaa aacccatgaa ggtaactaac ggaaggaaaa actaagagaa tgaaaagtat 5641 ttgcctctgg aaagaacaac tggcaggact gttgttttca ttgtaagact tttggagcca 5701 tttaattgta cttaaccatt ttcatctatt tctttaataa gaacaattcc atcttaataa 5761 agagttacac ttgttaataa gtgctggcct cctgttgttc tttgtacacc ccacacaaaa 5821 tttcaaagaa actttgatgg caatatatct ccatggtcag cttaaaaata gagaaaggaa 5881 aacatagaat tagccaagag tcacacaaaa caaagatcag ttgtttgtta ggaaacaatc 5941 aaaatcaagt ctcacttttt ccagattggc ttatggaaca gcactgtaag gtgataactt 6001 ggggcaaaca tgtaaataat aaaacatatg ttttaaatat tcaggttagc acattttatg 6061 tttctgtgag attaaaattg tgtgtgacat acccgcttcc ttaaaggcaa tgtttctgaa 6121 aatgttgtac ctgctattcc tgaatcaggg atgggtccca gaatctgcct tttaaacatc 6181 tcagataatc tgaagcctgc ttaagtttgt aaggcactgc ttttgcactc taaggaagaa 6241 aaaaacaagt tttaattccc gtctct //