LOCUS EU664602 17122 bp DNA linear BCT 26-JUL-2016 DEFINITION Salmonella enterica subsp. enterica serovar Kentucky strain 01-2100 Salmonella genomic island 1 variant SGI1-K1, partial sequence. ACCESSION EU664602 VERSION EU664602.1 KEYWORDS . SOURCE Salmonella enterica subsp. enterica serovar Kentucky ORGANISM Salmonella enterica subsp. enterica serovar Kentucky Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella. REFERENCE 1 (bases 1 to 17122) AUTHORS Doublet,B., Praud,K., Bertrand,S., Collard,J.M., Weill,F.X. and Cloeckaert,A. TITLE Novel insertion sequence- and transposon-mediated genetic rearrangements in genomic island SGI1 of Salmonella enterica serovar Kentucky JOURNAL Antimicrob. Agents Chemother. 52 (10), 3745-3754 (2008) PUBMED 18676889 REFERENCE 2 (bases 1 to 17122) AUTHORS Doublet,B., Praud,K., Bertrand,S., Collard,J.-M., Weill,F.-X. and Cloeckaert,A. TITLE Direct Submission JOURNAL Submitted (02-APR-2008) UR1282 Infectiologie Animale Sante Publique, Institut National de la Recherche Agronomique, Nouzilly 37380, France FEATURES Location/Qualifiers source 1..17122 /organism="Salmonella enterica subsp. enterica serovar Kentucky" /mol_type="genomic DNA" /strain="01-2100" /serovar="Kentucky" /sub_species="enterica" /db_xref="taxon:192955" misc_feature <1..16961 /note="Salmonella genomic island 1 variant SGI1-K1" gene complement(<1..>1325) /gene="S005delta" misc_feature complement(<1..>1325) /gene="S005delta" /note="nonfunctional putative mating pair stabilization protein due to insertion sequence disruption" mobile_element complement(1326..2583) /note="similar to ISVch4 from Vibrio cholerae chromosome" /mobile_element_type="insertion sequence:ISVch4" repeat_region complement(1326..1361) /note="right inverted repeat (IRR)" gene complement(1334..2206) /gene="orfB" CDS complement(1334..2206) /gene="orfB" /note="overlap with orfA characteristic of IS3 family members; possible frameshift" /codon_start=1 /transl_table=11 /product="putative transposase" /protein_id="ACH85842.1" /translation="MIIKKLKQSHSVKILCEVFNVHRSSYHYWLKRPALINAETIKLR SLISEAHAASNGSAGARTIADIVTNQGVKLSRYRATKLMRTLGLVSCQEPKHRYRKAS QEHIDVPNHLSRQFAVTAPNEVWAGDVTYIWTGNRWMYLAVVIDLFARKVIGWSMSLS PDSRLTGKALSMAYESRGKPKGVMFHSDQGSHYTSRKYRQLLWRFQIKQSLSRRGNCW DNAPIERFFRSLKTEWVPTVGYRSFAEAQQEITRYIIGYYCQLRPHQYNGGLTPNESE RLYWENSKTVANFS" gene complement(2200..2547) /gene="orfA" CDS complement(2203..2547) /gene="orfA" /codon_start=1 /transl_table=11 /product="putative transposase" /protein_id="ACH85843.1" /translation="MISSPHKLTGDIMTKRTRRLFSAEFKLEAAQLVLDQNYSVTEAA QAMNVGKSTMDKWVRQLREERQGKTPKASPMTPEQIEIRELKKKLARLEEHNEILKKA TALLMSDSLNNS" repeat_region complement(2548..2583) /note="left inverted repeat (IRL)" gene <2584..2778 /gene="S009delta" misc_feature <2584..2778 /gene="S009delta" /note="nonfunctional hypothetical protein due to insertion sequence disruption" gene complement(2798..3052) /gene="S010" CDS complement(2798..3052) /gene="S010" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ACH85858.1" /translation="MSKRAEYRRAIKELKVMILLGEGRWLNEKPISCGNKKFIVDGSV LNNVIREHPELNKHILIGFFSSPQRYPLLRYKDRQLTLSL" gene complement(3052..>3112) /gene="S011" CDS complement(3052..>3112) /gene="S011" /note="coding region disrupted by sequencing gap" /codon_start=2 /transl_table=11 /product="putative pilus assembly protein" /protein_id="ACH85844.1" /translation="AGGYLAPVSRYLSVAKGGR" gap 3113..3212 /note="equivalent to approximately 17.728 kb in SGI1 with GenBank Accession Number AF261825 followed by 10 kb of SGI1-K with GenBank Accession Number AY463797" /estimated_length=unknown gene <3213..3322 /gene="merR" CDS <3213..3322 /gene="merR" /note="coding region disrupted by sequencing gap" /codon_start=3 /transl_table=11 /product="merR repressor protein" /protein_id="ACH85845.1" /translation="LSELVCACHARKGNVSCPLIASLQGEAGLARSAMP" gene complement(3528..4178) /gene="tetR" CDS complement(3528..4178) /gene="tetR" /codon_start=1 /transl_table=11 /product="tetracycline resistance repressor protein" /protein_id="ACH85846.1" /translation="MTKLQPNTVIRAALDLLNEVGVDGLTTRKLAERLGVQQPALYWH FRNKRALLDALAEAMLAENHTHSVPRADDDWRSFLIGNARSFRQALLAYRDGARIHAG TRPGAPQMETADAQLRFLCEAGFSAGDAVNALMTISYFTVGAVLEEQAGDSDAGERGG TVEQAPLSPLLRAAIDAFDEAGPDAAFEQGLAVIVDGLAKRRLVVRNVEGPRKSDD" gene 4284..5483 /gene="tet(A)" CDS 4284..5483 /gene="tet(A)" /codon_start=1 /transl_table=11 /product="tetracycline resistance efflux pump" /protein_id="ACH85847.1" /translation="MKPNRPLIVILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAH YGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIG RIVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPH APFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAV FFIMQLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGE RRALMLGMIADGTGYILLAFATRGWMAFPIMVLLATGGIGMPALQAMLSRQVDEERQG QLQGSLAALTSLTSIVGPLLFTAIYAASITTWNGWAWIAGAALYLLCLPALRRGLWSG AGQRADR" gene complement(5515..6399) /gene="pecM" CDS complement(5515..6399) /gene="pecM" /note="efflux of the blue pigment indigoidine" /codon_start=1 /transl_table=11 /product="PecM like protein" /protein_id="ACH85848.1" /translation="MSLRTPDLLFTAIAPAIWGSTYIVTTQYLPNFSPMTVAMLRALP AGLLLVMIVRQIPTGIWWMRIFILGALNISLFWSLLFISVYRLPGGVAATVGAVQPLM VVFISAALLGSPIRLMAVLGAICGTAGVALLVLTPNAALDPVGVAAGLAGAVSMAFGT VLTRKWQPPVPLLTLTARQLAAGGLLLVPVALVFDPPIPMPTGTNVLGLAWLGLIGAG LTYFLWFRGISRLEPTVVSLLGFLSPGTAVLLGWLFLDQTLSALQIIGVLLVIGSIWL GQRSNRTPRARIACRKSP" gene 6888..8684 /gene="tnpA" CDS 6888..8684 /gene="tnpA" /note="similar to transposase of Tn1721" /codon_start=1 /transl_table=11 /product="transposase protein" /protein_id="ACH85849.1" /translation="MFILFAERKVGEQHGPAAQGVLAAVQTLREMNADNLRKVPADAP TAFIKPRWKPLVITPEGLDRKFYEICALSELKNALRSGDIWVKGSRQFRDFDDYLLPA EKFAALKREQALPLAINPNSDQYLEERLQLLDEQLATVTRLAKDNELPDAILTESGLK ITPLDAAVPDRAQALIDQTSQLLPRIKITELLMDVDDWTGFSRHFTHLKDGAEAKDRT LLLSAILGDAINLGLTKMAESSPGLTYAKLSWLQAWHIRDETYSAALAELVNHQYRHA FAAHWGDGTTSSSDGQRFRAGGRGESTGHVNPKYGSEPGRLFYTHISDQYAPFSTRVV NVGVRDSTYVLDGLLYHESDLRIEEHYADTAGFTDHVFALMHLLGFRFAPRIRDLGET KLYVPQGVQAYPTLRPLIGGTLNIKHVRAHWDDILRLASSIKRGTVTASLMLRKLGSY PRQNGLAVALRELGRIERTLFILDWLQSVELRRRVHAGLNKGEARSSLARAVFFNRLG EIGDRSFEQQRYRASGLNLVTAAIVLWNTVYLERATQGLVEAGKPVDGELLQFLSPLG WEHINLTGDYVWRQSRRLEDGKFRPLRMPGKP" gene complement(9223..10059) /gene="strB" CDS complement(9223..10059) /gene="strB" /note="aminoglycoside phosphotransferase; streptomycin resistance" /codon_start=1 /transl_table=11 /product="APH(6)-Id" /protein_id="ACH85850.1" /translation="MFMPPVFPAHWHVSQPVLIADTFSSLVWKVSLPDGTPAIVKGLK PIEDIADELRGADYLVWRNGRGAVRLLGRENNLMLLEYAGERMLSHIVAEHGDYQATE IAAELMAKLYAASEEPLPSALLPIRDRFAALFQRARDDQNAGCQTDYVHAAIIADQMM SNASELRGLHGDLHHENIMFSSRGWLVIDPVGLVGEVGFGAANMFYDPADRDDLCLDP RRIAQMADAFSRALDVDPRRLLDQAYANGCLSAAWNADGEEEQRDLAIAAAIKQVRQT SY" gene complement(10059..10862) /gene="strA" CDS complement(10059..10862) /gene="strA" /note="aminoglycoside 3'-phosphotransferase; streptomycin resistance" /codon_start=1 /transl_table=11 /product="APH(3'')-Ib" /protein_id="ACH85851.1" /translation="MNRTNIFFGESHSDWLPVRGGESGDFVFRRGDGHAFAKIAPASR RGELAGERDRLIWLKGRGVACPEVINWQEEQEGACLVITAIPGVPAADLSGADLLKAW PSMGQQLGAVHSLSVDQCPFERRLSRMFGRAVDVVSRNAVNPDFLPDEDKSTPQLDLL ARVEREPPVRLDQERTDMVVCHGDPCMPNFMVDPKTLQCTGLIDLGRLGTADRYADLA LMIANAEENWAAPDEAERAFAVLFNVLGIEAPDRERLAFYLRLDPLTWG" mobile_element complement(10931..12162) /mobile_element_type="insertion sequence:IS1133" repeat_region complement(10931..10958) /note="right inverted repeat (IRR)" /rpt_type=inverted gene complement(10969..11826) /gene="orfB" CDS complement(10969..11826) /gene="orfB" /codon_start=1 /transl_table=11 /product="putative transposase" /protein_id="ACH85852.1" /translation="MRFQFITDYRGSLSRSRICRLIGVTDRGLRAWKRRPPSLRQRRD LILLAHIREQHRLCLGSYGRPRMTEELKALGLQVGQRRVGRLMRQNNITVVRTRKFKR TTDSHHTFNTAPNLLKQDFSASAPNQKWAGDITYVWTREGWVYLAVILDLYSRRVIGW ATGDRLKQDLALRALNMALALRKPPPGCIQHTDRGSQYCAHEYQKLLLKHQLLPSMSG KGNCFDNSAVESFFKSLKAELIWRRHWQTRRDIEIAIFEYINGFYNPRRRHSTLGWKS PVAFEKKAA" gene complement(11823..12098) /gene="orfA" CDS complement(11823..12098) /gene="orfA" /codon_start=1 /transl_table=11 /product="putative transposase" /protein_id="ACH85853.1" /translation="MSLKHSDEFKRDAVRIALTSGLTRRQVASDLSIGLSTLGKWIAS ISDETKIPTQDTDLLRENERLRKENRILREEREILKKAAIFFAVQKL" repeat_region complement(12135..12162) /note="left inverted repeat (IRL)" /rpt_type=inverted gene complement(12163..>12662) /gene="tnpRdelta" misc_feature complement(12163..>12662) /gene="tnpRdelta" /note="nonfunctional putative resolvease due to insertion sequence disruption" mobile_element 12663..13482 /mobile_element_type="insertion sequence:IS26" gene 12726..13430 /gene="tnpA" CDS 12726..13430 /gene="tnpA" /codon_start=1 /transl_table=11 /product="putative transposase" /protein_id="ACH85854.1" /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDH STIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETHVKVNGRWAYLYRAVDSRGRTV DFYLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDV EHRQIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYY GDPLGEMRLVSRVFEM" repeat_region 13469..13482 /note="right inverted repeat (IRR)" /rpt_type=inverted gene 13669..14226 /gene="tnpR" CDS 13669..14226 /gene="tnpR" /note="similar to resolvase protein of Tn3" /codon_start=1 /transl_table=11 /product="putative resolvase protein" /protein_id="ACH85855.1" /translation="MRLFGYARVSTSQQSLDLQVRALKDAGVKANRIFTDKASGSSTD REGLDLLRMKVEEGDVILVKKLDRLGRDTADMIQLIKEFDAQGVAVRFIDDGISTDGD MGQMVVTILSAVAQAERRRILERTNEGRQEAKLKGIKFGRRRTVDRNVVLTLHQKGTG ATEIAHQLSIARSTVYKILEDERAS" gene 14408..15268 /gene="blaTEM-1" CDS 14408..15268 /gene="blaTEM-1" /note="Beta-lactamase protein; resistance to ampicillin" /codon_start=1 /transl_table=11 /product="TEM-1" /protein_id="ACH85856.1" /translation="MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGY IELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVE YSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRL DRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPL LRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIA EIGASLIKHW" repeat_region complement(15677..16690) /note="right inverted repeat (IRR)" /rpt_type=inverted repeat_region 15677..16496 /note="left inverted repeat (IRL)" /rpt_type=inverted mobile_element complement(15677..16496) /mobile_element_type="insertion sequence:IS26" gene complement(15729..16433) /gene="tnpA" CDS complement(15729..16433) /gene="tnpA" /codon_start=1 /transl_table=11 /product="putative transposase protein" /protein_id="ACH85857.1" /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDH STIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTV DFYLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDV EHRQIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYY GDPLGEMRLVSRVFEM" mobile_element complement(16483..16496) /note="left inverted repeat (IRL)" /mobile_element_type="insertion sequence:IS26" gene <16497..16834 /gene="S044delta" misc_feature <16497..16834 /gene="S044delta" /note="nonfunctional hypothetical protein due to insertion sequence disruption" repeat_region 16944..16961 /note="DR-R (imperfect repeat defining the right end of SGI1)" BASE COUNT 3925 a 4642 c 4456 g 3998 t ORIGIN 1 catgctccca gtactttgga cttgcagtaa gatccaacgt atgtgcagct atttagtgct 61 cttttagcat tcatggtgaa ctccttttcc tcgcacttcc aaatcatttg gatcatgacc 121 atcgacacta catagactgt gtaaacagtc ataacggtgc ttagcatggc ggcaccttgt 181 tggccgagga tttgttcagt cattgattca ggagccccag caggtacgcc agcggctccc 241 gtcgcagaag catttcctag agcttcagaa gtcagcttgg taatttgctc ctttaatgcg 301 ccaatagtct cctgggcaaa ctgttgaaca ggctggagaa aactatcaac cgctccacta 361 atattttcta tataacttgc aaaaggctgt gttatttcgg tccagccaga cattacgggg 421 tctcttaata cttggtatgc tcctttcacg gcactgccat cagagagtcc cataacggca 481 ccgtctagct taggcacggc cataatcaaa ttgagataat cagcaaacga aatattcgtc 541 ggcttttcac aacaatctga gacaccaccc acagcaatct tgcattcccc agcctcaccg 601 gcaaaagctg aacacatcac attttcttca ccagtggggt tatcatcata attttgacca 661 gtacaactca tatcctgagt catgaactga gctgcattca acaatgcaga tgcacgagcg 721 aaatcagtgc tttgtgactt tgttatatcg agacaatcat cccccataca cctaatgggt 781 ccaccacatt gatacgtcgt ttctttctct aaagtaggta ttgatatgtc cgttccgcag 841 tcgtaggtat ctttaaacac ataacactta cccgaggaac cctctgctcc atcaatacat 901 tcagaactaa taaatccaca ctgaggatta tcctcataca tctggcaact gttgagattt 961 ccaccagtat ttacagggca gtgtgtttca ccttgaggat ctgtccagca gtccatttgc 1021 cccttataaa agtcatagtc ggctttaact cgaacctttt tgcacagctt tggaatgcca 1081 gggaaaggtg acggtttcag ttgggattcg caaactttga ccccgttgat gactgtgcag 1141 cccgtagcat cagtcgggtc atctatacat gttatctcgc cttcggcaaa accatctaca 1201 acccctttgg ctgaatccat gcagctctgt ggagcccact catccttggt aatggctttc 1261 gatgggtcat agcggagttt tatgcggcca aaaccctcac cttcaccagt tactgaaaca 1321 cggattgtag tggtcaacta aaattggcca cggttttaga gttttcccaa tataatcgtt 1381 ctgattcatt gggagttaga ccaccgttat actgatgtgg cctgagttgg cagtaatatc 1441 cgataatgta gcgggtgatc tcttgttgag cctcagcgaa gctacgataa cccacagttg 1501 gcacccattc cgtcttcaga cttctaaaga agcgctctat cggcgcatta tcccaacagt 1561 ttcctcggcg agataaactc tgttttattt gaaagcgcca cagtaattga cggtatttac 1621 ggctagtata atgactgcct tgatcgctat ggaacatgac accttttggc tttccgcgag 1681 attcataggc catagacagc gctttacctg tcaaccgact atcaggcgac aaagacattg 1741 accaaccaat cactttgcgg gcaaaaagat cgataacgac cgctaaatac atccaccgat 1801 tacctgtcca aatatacgta acatcgccag cccaaacttc atttggagcc gtaacagcaa 1861 attgacgact taagtgattt ggaacgtcaa tatgttcttg tgaagccttt ctgtaacgat 1921 gctttggttc ttggcagctt actaaaccaa gagttctcat tagctttgtt gctcggtatc 1981 ggctcagctt tacaccctga tttgtgacta tatctgcaat ggttctcgct cccgcagagc 2041 cattgcttgc ggcgtgagcc tcgctaatca agctgcgcag ttttattgtt tccgcattaa 2101 ttaacgctgg gcgtttaagc caatagtgat aactacttcg atgaacattg aagacttcgc 2161 ataatatttt tacgctgtgg ctctgcttga gtttcttgat tatcaagaat tgttcagtga 2221 gtccgacatc aagagagccg tggctttttt tagtatttca ttatgctctt caaggcgagc 2281 cagcttcttt ttcaattccc gaatttctat ttgctcaggg gtcataggtg aagctttagg 2341 tgttttccct tggcgttctt ctctaagctg gcgaacccat ttatccatcg tggacttgcc 2401 cacattcatg gcttgggctg cttccgtcac tgagtaattt tggtctaaga ctagctgcgc 2461 tgcttctaac ttaaattctg cgctaaatag tcgtcttgta cgttttgtca taatgtcacc 2521 tgttaactta tgaggtgatg atatcacctc taactaagtg accaaattca ctatgccact 2581 acagtttctc tgctggcatc tttaaagatt ggtagaagag cctatctaat cagtaattcc 2641 gggagtaaaa cgaacacatt atctgggcga gatctgtttg cagacgtcac atacaaccct 2701 gccacaggat ctccaatggt aagtgacgta gatgtatccg gaagcttcta tggattgaat 2761 aaaaacaaag gctcctgaga gcctttgttt ttattcatta tagacttaac gttaactgcc 2821 tatctttata tcttaataac ggataccgtt gaggcgacga aaaaaaacct atcaaaatgt 2881 gtttattaag ttccggatgc tctctgatta cattgttcaa caccgaacca tcgacgataa 2941 attttttatt tccacaggag attggctttt cgtttagcca tctcccttcc cccagtaata 3001 tcatcacttt aagctcttta attgcgcgtc tatattcagc tcgtttgctc attaacggcc 3061 tcctttggct acggacaaat accttgatac aggcgctaaa tatccgcccg ctnnnnnnnn 3121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntgctgtct gaactcgtgt gcgcctgcca 3241 tgcacgaaag gggaatgttt cctgcccgtt gatcgcgtca ctacagggcg aagcaggcct 3301 ggcaaggtca gctatgcctt agcgtgcttt gttttccgtt ttctgaggtg ccccccagaa 3361 ggccgccaga gaggccgagc gcggccgtga ggcttggacg ctagggcagg gcatgaaaaa 3421 gcccgtagcg ggctgctacg ggcgtctgac gcggtggaaa gggggagggg atgttgtcta 3481 catggctctg ctgtagtgag tgggttgcgc tccggcagcg gtcctgatca atcgtcactc 3541 tttctcggtc cttcaacgtt cctgacaacg agcctccttt tcgccaatcc atcgacaatc 3601 accgcgagtc cctgctcgaa cgctgcgtcc ggaccggctt cgtcgaaggc gtctatcgcg 3661 gcccgcaaca gcggcgagag cggagcctgt tcaacggtgc cgccgcgctc gccggcatcg 3721 ctgtcgccgg cctgctcctc aagcacggcc ccaacagtga agtagctgat tgtcatcagc 3781 gcattgacgg cgtccccggc cgaaaaaccc gcctcgcaga ggaagcgaag ctgcgcgtcg 3841 gccgtttcca tctgcggtgc gcccggtcgc gtgccggcat ggatgcgcgc gccatcgcgg 3901 taggcgagca gcgcctgcct gaagctgcgg gcattcccga tcagaaatga gcgccagtcg 3961 tcgtcggctc tcggcaccga atgcgtatga ttctccgcca gcatggcttc ggccagtgcg 4021 tcgagcagcg cccgcttgtt cctgaagtgc cagtaaagcg ccggctgctg aacccccaac 4081 cgttccgcca gtttgcgtgt cgtcagaccg tctacgccga cctcgttcaa caggtccagg 4141 gcggcacgga tcactgtatt cggctgcaac tttgtcatgc ttgacacttt atcactgata 4201 aacataatat gtccaccaac ttatcagtga taaagaatcc gcgcgttcaa tcggaccagc 4261 ggaggctggt ccggaggcca gacgtgaaac ccaacagacc cctgatcgta attctgagca 4321 ctgtcgcgct cgacgctgtc ggcatcggcc tgattatgcc ggtgctgccg ggcctcctgc 4381 gcgatctggt tcactcgaac gacgtcaccg cccactatgg cattctgctg gcgctgtatg 4441 cgttgatgca atttgcctgc gcacctgtgc tgggcgcgct gtcggatcgt ttcgggcggc 4501 ggccggtctt gctcgtctcg ctggccggcg ctgctgtcga ctacgccatc atggcgacgg 4561 cgcctttcct ttgggttctc tatatcgggc ggatcgtggc cggcatcacc ggggcgactg 4621 gggcggtagc cggcgcttat attgccgata tcactgatgg cgatgagcgc gcgcggcact 4681 tcggcttcat gagcgcctgt ttcgggttcg ggatggtcgc gggacctgtg ctcggtgggc 4741 tgatgggcgg tttctccccc cacgctccgt tcttcgccgc ggcagccttg aacggcctca 4801 atttcctgac gggctgtttc cttttgccgg agtcgcacaa aggcgaacgc cggccgttac 4861 gccgggaggc tctcaacccg ctcgcttcgt tccggtgggc ccggggcatg accgtcgtcg 4921 ccgccctgat ggcggtcttc ttcatcatgc aacttgtcgg acaggtgccg gccgcgcttt 4981 gggtcatttt cggcgaggat cgctttcact gggacgcgac cacgatcggc atttcgcttg 5041 ccgcatttgg cattctgcat tcactcgccc aggcaatgat caccggccct gtagccgccc 5101 ggctcggcga aaggcgggca ctcatgctcg gaatgattgc cgacggcaca ggctacatcc 5161 tgcttgcctt cgcgacacgg ggatggatgg cgttcccgat catggtcctg cttgctacgg 5221 gtggcatcgg aatgccggcg ctgcaagcaa tgttgtccag gcaggtggat gaggaacgtc 5281 aggggcagct gcaaggctca ctggcggcgc tcaccagcct gacctcgatc gtcggacccc 5341 tcctcttcac ggcgatctat gcggcttcta taacaacgtg gaacgggtgg gcatggattg 5401 caggcgctgc cctctacttg ctctgcctgc cggcgctgcg tcgcgggctt tggagcggcg 5461 cagggcaacg agccgatcgc tgatcgtgga aacgataggc ctatgccatg cgggtcaagg 5521 cgacttccgg caagctatac gcgccctagg agtgcggttg gaacgttggc ccagccagat 5581 actcccgatc acgagcagga cgccgatgat ttgaagcgca ctcagcgtct gatccaagaa 5641 caaccatcct agcaacacgg cggtccccgg gctgagaaag cccagtaagg aaacaactgt 5701 aggttcgagt cgcgagatcc cccggaacca aaggaagtag gttaaacccg ctccgatcag 5761 gccgagccac gccaggccga gaacattggt tcctgtaggc atcgggattg gcggatcaaa 5821 cactaaagct actggaacga gcagaagtcc tccggccgcc agttgccggg cggtaagggt 5881 gagcagaggc acgggaggtt gccacttgcg ggtcagcacg gttccgaacg ccatggaaac 5941 cgcccccgcc aggcccgctg cgacgccgac aggatctagc gctgcgtttg gtgtcaacac 6001 caacagcgcc acgcccgcag ttccgcaaat agcccccagg accgccatca atcgtatcgg 6061 gctacctagc agagcggcag agatgaacac gaccatcagc ggctgcacag cgcctaccgt 6121 cgccgcgacc ccgcccggca ggcggtagac cgaaataaac aacaagctcc agaatagcga 6181 aatattaagt gcgccgagga tgaagatgcg catccaccag attcccgttg gaatctgtcg 6241 gacgatcatc acgagcaata aacccgccgg caacgcccgc agcatcgcga ccgtcatcgg 6301 tgagaagttc ggcaggtatt gggtggtgac aatgtaggtg ctgccccaaa tggcaggtgc 6361 tatcgctgtg aacaataaat cgggcgtgcg taatgacatg cgattacaag acctccgcta 6421 cggcgatggg tttttgagag ttgcaggcgc cgcgatgacc gcaccctgac ttggactggc 6481 cctgcctcgc accaatccac ctgcggctat ggccgcgatc atgcgaggcc cgaaaattac 6541 acgacctgta cacgtccgcc gaactcggaa cgcaacagag cttcgtgggc atcccgatcc 6601 gggtcgtagc agcagtcctg gaccaaacgc acgtcgtagt ccgcatcact agcccaggcg 6661 acgcttgaaa gaacaacgcc ggtggtgctt atcccggcca tgacaagcgt gcttacgccg 6721 cgcgtccgaa ggtcggcgtc gagcgccgtg ccataaaaga cgctggctcg cggacatgca 6781 tagaaaaggt cgccccgttc gatcgcaagc ccttcgacgg gcagaccggt gcgaaatcgt 6841 ccgctcggga gatacggtga gatttggcga ttcgtcgccg gcggcgcatg ttcatactct 6901 tcgccgagcg aaaagttggg gaacagcacg ggccggccgc gcaaggcgtg ctggcagccg 6961 tgcagaccct gcgtgagatg aacgccgaca acctgcgcaa ggtgccggcc gatgcaccca 7021 cggccttcat caagccgcgc tggaagccgc tggtgatcac cccggaaggc ctcgaccgga 7081 aattctacga aatctgcgcc ctgtccgagc tgaagaacgc cctgcgctcc ggcgacatct 7141 gggtcaaggg ctcgcggcag ttccgcgact tcgacgacta cctgctgccg gccgagaagt 7201 tcgccgcact caagcgcgag caggccctgc ccctggcgat caacccgaac agcgaccagt 7261 acctggaaga gcgtttgcag ctgctggacg agcagttggc caccgtcacc cgcctggcca 7321 aggacaacga gctgcccgat gccatcctca ccgagtcagg gctgaaaatc accccgctgg 7381 atgcggcggt gccggatcgg gcgcaggcgc tgatcgacca aaccagccag ttactgccgc 7441 gcatcaagat caccgaactg ctgatggacg tggacgactg gacgggcttc agccgccact 7501 tcacccactt gaaggacggg gccgaggcca aagacaggac gttgctgctg tccgcaatcc 7561 tcggtgatgc gatcaacctc gggctgacca agatggccga gtcgagcccc ggcctgacct 7621 acgccaagct gtcctggctg caagcctggc acatccgcga cgaaacctat tcggcggcct 7681 tggccgagct ggtcaaccac cagtatcgcc acgcctttgc cgcccactgg ggcgacggca 7741 cgacctcatc ctccgatggc cagcgcttcc gcgcgggtgg ccggggcgag agcaccgggc 7801 acgtcaaccc gaagtacggt agcgagccgg gacggctgtt ctatacccat atctccgacc 7861 agtacgcgcc gttcagcacc cgcgtggtga atgtcggcgt ccgcgattcc acctatgtgc 7921 tcgacggcct gctgtaccac gagtccgacc tgcggatcga ggagcactac gccgacacgg 7981 ccggcttcac cgatcacgtc tttgccctga tgcacctgct aggcttccgc ttcgcgccgc 8041 gcatccgcga cctcggcgaa accaagctgt acgtgccgca gggcgtgcaa gcctacccga 8101 cgttgcgccc gctgatcggc ggcaccctga acatcaagca cgtgcgtgcc cactgggacg 8161 acatcctgcg cctggccagc tcgatcaagc ggggcaccgt caccgcctcg ctgatgctgc 8221 gcaagctcgg cagctacccg cgccagaacg gactggccgt ggccctgcgc gagctgggcc 8281 ggatcgagcg cacgctgttc atcctggact ggctgcaaag tgttgaactg cgccgccgcg 8341 tgcatgccgg cctgaacaaa ggtgaggcgc gcagctcgct ggccagggcg gtgttcttca 8401 accgccttgg ggaaatcggg gatcggagct tcgagcagca gcgctaccgg gccagcggcc 8461 tcaacctggt gacggcggct atcgtgctgt ggaacacggt gtacctggaa cgcgccaccc 8521 aggggttggt cgaggccggc aagccggtgg acggcgagct gctgcaattc ctgtcgccgc 8581 tgggctggga gcacatcaac ctaaccggcg attacgtctg gcggcagagc cgcagactgg 8641 aggacgggaa gtttcggccc ttacggatgc ccggaaaacc ttagcgtacg attttttccg 8701 aattctgcgg gctccccata taggcagcgc taagggcaat ccgtgggtac aggatattaa 8761 ccaccgcgtt actttgtggt tgccctggcg gataggcttt gtacgaggag ggaatcattc 8821 tattgccagc ggcgttctgg ccggtgaggg tgaggtaata cccgatacgg tttatgatat 8881 gcggtatttg ctcgatattg tcagcactga cgggtattac tggtacatga gcgggaagat 8941 ctgcgagaga gtcagtgact accgtacagc cgcctttttt gaaataggcc gcctgcttac 9001 actgtgatcc cttcaaaata tctcaacgaa atttcccgac acctgtttaa gctatcttgc 9061 tgatatttct gtttttcgat ttttgccggc gcgacgccgg cgacgttggc cagctggggg 9121 tcgtttgcgg gagagggcga aatcctacgc taaggctttg gccaacgata ttctccggta 9181 agattgatgt gttcccaggg gataggagaa gtcgcttgat atctagtatg acgtctgtcg 9241 cacctgcttg atcgcggccg cgatagctag atcgcgttgc tcctcttctc catccgcgtt 9301 ccaagctgcg gaaaggcacc cattagcgta cgcctggtcg agcaggcgac gcggatcgac 9361 gtccagcgca cgagagaatg cgtccgccat ctgtgcaatg cgtctaggat cgagacaaag 9421 gtcgtctctg tcagccggat cgtagaacat attggcggcg ccaaagccca cttcaccgac 9481 cagaccgacg ggatctatca ccagccagcc gcgactggag aacatgatgt tttcatgatg 9541 cagatcgcca tgtagcccac gcagttccga ggcattgctc atcatttgat cggctataat 9601 cgccgcgtgg acgtagtcag tttgacaacc tgcgttttga tcatcgcgcg cccgctgaaa 9661 caaagctgca aagcgatccc ggatcgggag aagggcagaa ggcaggggtt cctcagatgc 9721 ggcatacagc ttcgccatta gttccgctgc aatttcggtc gcctggtagt cgccgtgctc 9781 ggcaacgatg tgagagagca ttcgctcccc ggcatattcg agcaacatca gattgttctc 9841 acgaccgagc aaccggactg ctcccctccc attgcgccat accagatagt cggccccgcg 9901 cagttcatca gcaatgtctt ctataggttt caatcccttg acgattgcag gagtcccgtc 9961 tggcaatgaa actttccaaa cgaggctgga aaaggtgtcc gcaatgagaa caggttgcga 10021 aacgtgccaa tgagcaggaa aaacaggcgg catgaacatc aaccccaagt cagagggtcc 10081 aatcgcagat agaaggcaag gcgttcgcgg tcgggggctt cgatccccaa tacattgaat 10141 aggacagcga aggcgcgctc cgcttcatct ggcgctgccc agttctcttc ggcgttagca 10201 atcatgagtg ccaaatcggc atagcgatct gctgttccga gccgcccaag gtcgatcaga 10261 cccgtgcatt gaagagtttt agggtccacc atgaagttcg gcatgcaggg atcaccatgg 10321 caaacaacca tatcggtgcg ctcttggtcg agccgcaccg gtggctctcg ttcgacacga 10381 gccaaaagat cgagctgcgg cgtactcttg tcctcgtccg gtaagaagtc gggattgacg 10441 gcattgcggg acaccacatc aacggcgcgt ccgaacattc gcgacagcct gcgctcaaac 10501 ggacattgat caaccgatag gctgtgaaca gcgccaagtt gctgccccat tgacggccac 10561 gctttgagca aatccgctcc agacagatca gccgccggta ctcccggaat tgccgttatc 10621 accaagcatg caccctcctg ttcctcctgc cagttgatga cctcggggca agccacacct 10681 cgacctttga gccaaatgag gcggtcacgc tctccagcga gctcaccgcg gcgggaagca 10741 ggtgcgattt tcgcgaaggc atgcccgtca ccacgtcgaa aaacaaaatc accagattct 10801 ccgcctctga caggcaacca gtcagaatgc gattcaccaa aaaaaatatt agttcgattc 10861 aatggaggtt ccttcagttt tctgatgaag cgcggaggtg gctaaacctg cgaaaagaaa 10921 cgagttgcta tggacttgca ccggttgtgt tccggtctat ctctcatttt aagcggcttt 10981 tttctcaaat gccaccggcg atttccagcc gagtgttgaa tgtcttcggc gtggattata 11041 aaagccattt atatattcga agattgcaat ctcaatatct cgccttgttt gccagtgtct 11101 gcgccaaatc aactcagcct ttaatgattt aaagaagctt tctactgcgg agttatcaaa 11161 acaattgcct ttcccgctca tggacggcag caattgatgt ttgagcagta gcttttgata 11221 ttcatgagcg caatattggc tcccacggtc tgtgtgttga atacaacccg gtggtggttt 11281 gcgtaaagcc aacgccatat tcagtgccct taatgcaaga tcctgcttta atcgatcacc 11341 tgttgcccag cctatcacgc gacgggaata caggtcaagg ataacagcaa gatagaccca 11401 tccttctctg gtccaaacat aagtgatatc gcctgcccat ttctggttgg gtgcgcttgc 11461 gctaaagtct tgttttaata ggttcggtgc agtgttgaag gtatgatgac tatccgttgt 11521 ccgtttgaat ttacgcgttc gaacaactgt aatgttattc tggcgcatca aacgtccaac 11581 ccgacgctgc ccaacctgca ggcccagcgc tttcaactct tctgtcatac gcggcctacc 11641 atagctcccc aaacacaacc gatgctgctc acgtatatgc gctagaagta taagatcacg 11701 acgctggcgc agtgatggag gacggcgttt ccatgcacgt aaaccacgat ctgttacgcc 11761 tatcaaacga catatgcgtg aacgtgagag agagccacgg taatccgtaa taaactgaaa 11821 tctcacagct tttgtactgc gaaaaatatt gctgcctttt ttaatatctc cctctcctcc 11881 cgaaggatac ggttctcttt gcgtaaacgt tcattctcac gcagaagatc agtgtcttgg 11941 gtaggaattt tagtttcatc ggaaattgat gcgatccatt tcccaagcgt ggaaagccca 12001 atacttaaat ctgacgcaac ttgacggcgt gttaagccac tagtgagtgc tatgcgaact 12061 gcatcacgct taaattcatc actatgcttt aatgacatat atggtctcct tgataacaaa 12121 taatgctctc aaaaagaccg gaacgaaacc gaggcaagtc cactacgtaa gtccgagaac 12181 atgctttcca tggtctctga gctcgccttt gggaccgaca tatcggtaga gagtgacgcg 12241 ctcgatgccg agttccttgc agagatcgga aactgaagta tcgcgctggg ccatggcggc 12301 ttgcgcgaga cgcacctgag ctttggtgag cgcgaatttt cgtccgccct tgcgaccgcg 12361 cgctctcgcg gaggcgagac ccgccatggt gcgctctcgg atcagatccc gctcgaactc 12421 ggccaaggtg gcgaagattc cgaacaccat gcgaccggac gcagtcgtgg tgtcgatctg 12481 agcgcccttt ccagtcagaa cccgcaggcc gatcttgcgg tctgacagct ccttcaccgt 12541 gttgaccaga tgggcaagcg atcgtccgag gcgatcgagc ttccagacca ccagcacatc 12601 gccgtcacgc aatgacttga ggcaggcagt caagccaggg cgatcatcac gaccgccgga 12661 agggcactgt tgcaaatagt cggtggtgat aaacttatca tccccttttg ctgatggagc 12721 tgcacatgaa cccattcaaa ggccggcatt ttcagcgtga catcattctg tgggccgtac 12781 gctggtactg caaatacggc atcagttacc gtgagctgca ggagatgctg gctgaacgcg 12841 gagtgaatgt cgatcactcc acgatttacc gctgggttca gcgttatgcg cctgaaatgg 12901 aaaaacggct gcgctggtac tggcgtaacc cttccgatct ttgcccgtgg cacatggatg 12961 aaacccacgt gaaggtcaat ggccgctggg cgtatctgta ccgggccgtc gacagccggg 13021 gccgcactgt cgatttttat ctctcctccc gtcgtaacag caaagctgca taccggtttc 13081 tgggtaaaat cctcaacaac gtgaagaagt ggcagatccc gcgattcatc aacacggata 13141 aagcgcccgc ctatggtcgc gcgcttgctc tgctcaaacg cgaaggccgg tgcccgtctg 13201 acgttgaaca ccgacagatt aagtaccgga acaacgtgat tgaatgcgat catggcaaac 13261 tgaaacggat aatcggcgcc acgctgggat ttaaatccat gaagacggct tacgccacca 13321 tcaaaggtat tgaggtgatg cgtgcactac gcaaaggcca ggcctcagca ttttattatg 13381 gtgatcccct gggcgaaatg cgcctggtaa gcagagtttt tgaaatgtaa ggcctttgaa 13441 taagacaaaa ggctgcctca tcgctaactt tgcaacagtg ccgtggtcag aaagtcaacg 13501 ggcatatcgg cctccctgcc tgacgggcat ttagtaacat ttctccaacc gtacgaaatg 13561 ttataaatta tcggacatcg taaaactgtt acattaatat gtctattaaa tcgtaaattt 13621 gtaataatag acatgagttg accgatattc gatttaaggt acatttttat gcgacttttt 13681 ggttacgctc gggtctcaac cagtcagcag tctcttgatc ttcaggtcag agcactcaaa 13741 gacgcaggtg tgaaagcaaa ccgtatattt accgataagg catccggcag ttcaacagac 13801 cgggaagggc tggatttgct gaggatgaag gtggaggaag gtgatgtcat tctggttaag 13861 aagctcgacc gtctnggccg cgacactgcc gatatgatcc aactgataaa ggaatttgac 13921 gctcagggcg tggcagtccg gttcattgat gacgggatca gtaccgacgg tgatatgggg 13981 caaatggtgg tcaccatcct gtcggctgtg gcacaggctg aacgccggag gatcctagaa 14041 cgcacgaatg agggccgaca ggaagcaaag ctgaaaggaa tcaaatttgg ccgcaggcgt 14101 accgtggaca ggaacgtcgt gctgacgctt catcagaagg gcactggtgc aacggaaatt 14161 gctcatcagc tcagtattgc ccgctccacg gtttataaaa ttcttgaaga cgaaagggcc 14221 tcgtgatacc ctatttttat aggttaatgt catgataata atggtttctt agacgtcagg 14281 tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc 14341 aaatatgtat ccgctcatga gacaataacc ctggtaaatg cttcaataat attgaaaaag 14401 gaagagtatg agtattcaac attttcgtgt cgcccttatt cccttttttg cggcattttg 14461 ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt 14521 gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt 14581 tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat gtggtgcggt 14641 attatcccgt gttgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa 14701 tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag 14761 agaattatgc agtgctgcca taaccatgag tgataacact gctgccaact tacttctgac 14821 aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac 14881 tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac 14941 cacgatgcct gcagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac 15001 tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact 15061 tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg 15121 tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt 15181 tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat 15241 aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta 15301 gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa 15361 tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccttttt 15421 caaaatctga tagcgttcaa gacgctttgt ttatgaagct ggttgagata catttccaga 15481 ggtcaatgca atcgtggccg aagcgccgcc tcaaaccaac gtttgtgata catgctgatc 15541 ggatatgccc gcgtctccaa agccgatggc tcgcagtctc tcgacctgca gcacgacgcc 15601 ttgcgcgccg caggtgtcga acgggacaat atctatgatg atcttgcttc cggcggtcgt 15661 gatgatcgcc ctggctggca ctgttgcaaa gttagcgatg aggcagcctt ttgtcttatt 15721 caaaggcctt acatttcaaa aactctgctt accaggcgca tttcgcccag gggatcacca 15781 taataaaatg ctgaggcctg gcctttgcgt agtgcacgca tcacctcaat acctttgatg 15841 gtggcgtaag ccgtcttcat ggatttaaat cccagcgtgg cgccgattat ccgtttcagt 15901 ttgccatgat cgcattcaat cacgttgttc cggtacttaa tctgtcggtg ttcaacgtca 15961 gacgggcacc ggccttcgcg tttgagcaga gcaagcgcgc gaccataggc gggcgcttta 16021 tccgtgttga tgaatcgcgg gatctgccac ttcttcacgt tgttgaggat tttacccaga 16081 aaccggtatg cagctttgct gttacgacgg gaggagagat aaaaatcgac agtgcggccc 16141 cggctgtcga cggcccggta cagatacgcc cagcggccat tgaccttcac gtaggtttca 16201 tccatgtgcc acgggcaaag atcggaaggg ttacgccagt accagcgcag ccgtttttcc 16261 atttcaggcg cataacgctg aacccagcgg taaatcgtgg agtgatcgac attcactccg 16321 cgttcagcca gcatctcctg cagctcacgg taactgatgc cgtatttgca gtaccagcgt 16381 acggcccaca gaatgatgtc acgctgaaaa tgccggcctt tgaatgggtt catgtgcagc 16441 tccatcagca aaaggggatg ataagtttat caccaccgac tatttgcaac agtgccctaa 16501 tttatggtct ggcattctga gaaactggaa ggataaaggg atcacctctg ctgaactttc 16561 ggttctaccc aggagccaca atcatcccga cgacaataca gatctattaa tagctattgc 16621 cggagaagtt cattggacgc tcgaagaggt agagcagtac ttcgttgatt acgatctggt 16681 aggcagtgac gacggccatc cttactatta cctagcgacg ttcagtgatg agacacctga 16741 cgagctgaag cgaattgcag ggctgaacag ctcaaatcaa cttcacatgg gtctaaacat 16801 agttccggat gaagatcagg gagaattcga gtagagtaat atcttcatat aatcaatact 16861 ttatgtgttt tgtgattggt aagttttact ccacatttac tccaaaaaac atataattta 16921 ttgatttaaa ataactaatt actttctgta ttggtaagta acgttgtatt gcccggtggc 16981 gcaatgctta ccgggcctac aaaacccgta agccggataa ggcgtttatg ccgccatccg 17041 gcagcaatga tttcccatgc ggaaatcact gttgtccaaa tggcaactcg tctcgcgcaa 17101 cgtcgccccg tattcttagc gc //