LOCUS EF094937 9411 bp DNA linear HUM 01-NOV-2009 DEFINITION Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide (YWHAZ) gene, complete cds. ACCESSION EF094937 VERSION EF094937.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 9411) AUTHORS Brennan,E.P., McKnight,A.J., Savage,D.A., Patterson,C.C. and Maxwell,A.P. TITLE YWHAZ screening JOURNAL Unpublished REFERENCE 2 (bases 1 to 9411) AUTHORS Brennan,E.P. TITLE Direct Submission JOURNAL Submitted (31-OCT-2006) Nephrology Group, Medical Genetics Centre, BCH, Queens University Belfast, Lisburn Road, Belfast, Co. Antrim, N.I BT9 7AB, UK FEATURES Location/Qualifiers source 1..9411 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="8" /map="8q22.3" /PCR_primers="fwd_name: YWHAZ_Pf1, fwd_seq: tcagtctgtcacccagg, rev_name: YWHAZ_Pr1, rev_seq: tgcccattctcctttgc" /PCR_primers="fwd_name: YWHAZ_Pf2, fwd_seq: tgcctgcggtcatacc, rev_name: YWHAZ_Pr2, rev_seq: cacaagtccatccctcc" /PCR_primers="fwd_name: YWHAZ_Pf3, fwd_seq: cacatcatcaacagagtcc, rev_name: YWHAZ_Pr3, rev_seq: acacttaactcatcaggtga" /PCR_primers="fwd_name: YWHAZ_Pf4, fwd_seq: caaatgaataatagctagg, rev_name: YWHAZ_Pr4, rev_seq: gtgactcacttaaaatgag" /PCR_primers="fwd_name: YWHAZ_Pf5, fwd_seq: caaatttctggtgcctacg, rev_name: YWHAZ_Pr5, rev_seq: ggaaggagaaaggcgga" /PCR_primers="fwd_name: YWHAZ_Pf6v3, fwd_seq: gctctctcattgctaacc, rev_name: YWHAZ_Pr6v3, rev_seq: gacccgtttctcgtagg" /PCR_primers="fwd_name: YWHAZ_Pf6v4, fwd_seq: gtcccggctcatcacc, rev_name: YWHAZ_Pr6v4, rev_seq: ctgagtgtggctgagtg" /PCR_primers="fwd_name: YWHAZ_Pf8, fwd_seq: gtagaggagctggaagc, rev_name: YWHAZ_Pr8, rev_seq: cctgggacaggaagcg" /PCR_primers="fwd_name: YWHAZ_Pf9, fwd_seq: aggcagttaggtttcagg, rev_name: YWHAZ_Pr9, rev_seq: acacacaatgtttagaagg" /PCR_primers="fwd_name: YWHAZ_Pf10, fwd_seq: ttattctcactatgtctg, rev_name: YWHAZ_Pr10, rev_seq: tcctttgaaatactaacc" /PCR_primers="fwd_name: YWHAZ_Pf11, fwd_seq: tgtgtaccaggagaaagc, rev_name: YWHAZ_Pr11v2, rev_seq: caagacaggtaactcatc" /PCR_primers="fwd_name: YWHAZ_Pf12, fwd_seq: cattcaggtatcttggc, rev_name: YWHAZ_Pr12, rev_seq: agagtaaaatgggtcac" /PCR_primers="fwd_name: YWHAZ_Pf13v2, fwd_seq: aactgcctacatactgg, rev_name: YWHAZ_Pr15v3, rev_seq: tcctggaaataaagacc" /PCR_primers="fwd_name: YWHAZ_Pf15v4, fwd_seq: ggtgagaaactgaaatcc, rev_name: YWHAZ_Pr15v2, rev_seq: tgggaggttgagatgg" /PCR_primers="fwd_name: YWHAZ_Pf16v2, fwd_seq: gttcaagcgattctcc, rev_name: YWHAZ_Pr16v3, rev_seq: ggacaatcaaggaatag" /PCR_primers="fwd_name: YWHAZ_Pf16v4, fwd_seq: aacctgaaacttggcac, rev_name: YWHAZ_Pr16v4, rev_seq: acttgcgaggctgagg" gene 3073..8333 /gene="YWHAZ" mRNA join(3073..3145,3847..3960,4211..4515,4762..4885, 5503..5666,5751..5846,6267..8333) /gene="YWHAZ" /product="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide" 5'UTR join(3073..3145,3847..3960,4211..4221) /gene="YWHAZ" exon 3073..3145 /gene="YWHAZ" /number=1_alt1 gap 3498..3597 /estimated_length=unknown exon 3847..3960 /gene="YWHAZ" /number=1_alt_2 gap 4004..4103 /estimated_length=unknown exon 4211..4515 /gene="YWHAZ" /number=2 CDS join(4222..4515,4762..4885,5503..5666,5751..5846, 6267..6326) /gene="YWHAZ" /note="protein kinase C inhibitor protein-1; phospholipase A2; 14-3-3 zeta" /codon_start=1 /product="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide" /protein_id="ABO15003.1" /translation="MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLL SVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLE KFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEM QPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIM QLLRDNLTLWTSDTQGDEAEAGEGGEN" gap 4627..4726 /estimated_length=unknown exon 4762..4885 /gene="YWHAZ" /number=3 exon 5503..5666 /gene="YWHAZ" /number=4 exon 5751..5846 /gene="YWHAZ" /number=5 gap 6079..6178 /estimated_length=unknown exon 6267..8333 /gene="YWHAZ" /number=6 3'UTR 6327..8333 /gene="YWHAZ" regulatory 7299..7304 /regulatory_class="polyA_signal_sequence" /gene="YWHAZ" polyA_site 7325 /gene="YWHAZ" BASE COUNT 2495 a 1953 c 1804 g 2759 t ORIGIN 1 tcagtctgtc acccaggctg gagtgcagtg gtgcaatcac agctcaccac agcctcaacc 61 tccgaggctc aagtgatcga tcctcctgcc tcagcccccc aagtagctgg atttacaggc 121 acatacaccc agctaatttt gtgtattttt tgtattgacg ggatttcacc atgttgccca 181 ggctgatctc caactcctgg gctcaagtga tccatccacc tcaccctccc acagacctgg 241 gattacaagc gtgagccact gcacttggcc tgtatttctt tcaactgcct tttatcaaaa 301 gatcagtttc cctttcctta ctctcatttt tcctcccctt ttctttcatt taaaaaaaaa 361 tctttcccat cttttagatt tgccaattac tttcacggac attatagtgc tagctgtttt 421 aacagataaa ctctcaattg cggcggccta aaatagaagt tatccctcag taaactccaa 481 aatgattggg gcaggctttc ataggcttcc agggacccag gctgtcttca ttttatgacc 541 tcactgcctc taagccctgg gaatcctctc cattcagccg gaaaaacagg aatggaatga 601 acattcaaac agggagattt ttatgggcca ggcctgcaag tggagcacat gcctgcggtc 661 ataccccatt agccagcact cagtaacatg gccacatgta attgcaaagg agaatgggca 721 atggagtcca actggggcag caagaggaga aaaatgggtt tggtgaatag ctagcttgtc 781 tctgctacta actgcagatt atttcaacaa cagatataca tgatctggtg tactacatgt 841 aggtagccct ttccttactt tctcatgaaa tcattgcaac aaccattata atgggattag 901 aaattggtat gtccaattca gaaacctaag gtcacacagt tctgaatgac aaaccaagat 961 ttagtccctg ttctgctgca aaaccttctg caatatgttg gatttctcca aataaaacac 1021 agtgaagtga aattatagcc tgacagaatt gtgattacac ttaaaatatc atataactgc 1081 cacatcatca acagagtcca tccttggaga tgttttccca attggaggga tggacttgtg 1141 ctaattcact taaactcttt cccattttag tgtttcattt ttgagacagg gtctcgcttt 1201 gttgcccagg ctgtagtgta gtgacacaat cacagctaac tgcagcctct accttccggg 1261 ctcaaatgat cctcccacct cagcctcccc agtagctggg accgcaggca catgccacca 1321 tgtccagcta ctttttgtat tttttgtaga gaaggggtct tgccatgttg cccaggctgg 1381 tcttgaaccc gtggactcaa gctatctgcc tgcctcccaa agtgctgaga taatgagagt 1441 gaaccactgt gcctgggctt tttctcattt taatgtatag cattatatat tgatgtatag 1501 ctttgaagag atcattgcag tcccctatag aggaatgaat caatattcac cctcatcact 1561 catgtctcag cactaagaaa cacaaatagg catttctatt tctaaaagat actttaaaaa 1621 tatggtttct ttctgctact gaagtttcct aaaaatcaaa aagaaaatag tttcatttta 1681 tctttacaat cttttgaaca ctagagatat caatcagata tatccattta caaatgaata 1741 atagctaggt tactctaaga aatatatgta tgtgtatatt cgtttaatcc tcagcatcac 1801 ctgatgagtt aagtgttttt gttgccagta ttttattgcc gtggctatca aagcacatag 1861 aggttaacca acttgagtga ggtaagagtt gcgcattgaa gaaaatacag gtcagggtat 1921 tagtgaaagt ctccagcaaa gttcccaggg ttcataggtt ctatttattc tgctctgtat 1981 gccacaggtt attccttatt tcttaaaaga tcttttcctc agggctttca taacatcccg 2041 ttcctttctt gcagcttcat tatatcttta ttgtgcagac acattgactt gagtatgtaa 2101 aacctaacag tgcctattgt tgcactaaaa aatgccttgc tattaaagca tgaggcaaaa 2161 gcctaactta gctgtttcct gaagtaaatc catatttata cagaaaaacc ccttaacttc 2221 ctctaaaaca aaaggcatat actctacata gacatatatt tgagacatta aagaaacatc 2281 aatttccatt ttaaaaaaac gtttaactta gtatcctctg tcaaatttct ggtgcctacg 2341 aaaaaactgt aaaaaaaata gcttttgaaa tattactcat tttaagtgag tcacgcccta 2401 aaagaattta cttgggagtc aaagctagtt gaccctaaca tctcagaaat aaaactccaa 2461 tttgtttatc catttaacct accatgagtc tgtgatttgg caacttgtga aaagcaacaa 2521 caaaaaaacc cactaaaata taactggtca ctggaaaccc tctttctggt ctgtactatc 2581 taaatgccag ctgtcatgtc aggcaaaaag taatttgtag agcagccttg tggtccactg 2641 tattatgtag gaaagacaat gtactggaag agcgaggact caatcatttc gtgtctacta 2701 ctgagaaact aaattctgta gagaacatga ggctaaacgg aggctctggt cagctcaata 2761 aagatacgtt ggaagaatca atggggagtt tacacaagag taaaatgaag agttccaagc 2821 tctctcattg ctaaccgtac actctccatg gctgttgcaa gtggttttgc aggtcatcca 2881 agcactaatc ttttcttagc ccgaacacat ttaaagaggg aaggggcaga gatcattcac 2941 actgtgaatg tttctctctg aacttcctga agtcaactgg gcggaggccc taccggttca 3001 ggcacctgca atttccgcct ttctccttcc ccttcttccg ggctcccgtc ccggctcatc 3061 acccggcctg tggcccactc ccaccgccag ctggaaccct ggggactacg acgtccctca 3121 aaccttgctt ctaggagata aaaaggtaat gatcgtcatg tgcagtatga ggtcttcacg 3181 tgaaagcttt atttgggtag gaaaacctag cctacgagaa acgggtccgt gcggtcacgc 3241 ctgactgcct gtctccgggt caaggctgcc aggaccagct ccagccctcc gcccgagaag 3301 gctgtccttt cccctcggaa ctctggcttc cctaaagcgg ccgcgcctcc ttccaggcct 3361 cacctcctgc cggctccgcc cggcccggcc cacctcgccc ccacctcggc gcccacccat 3421 tgtcccctcg cgcagtcacc gagcgcagat cccgcgctct cgattggaac gcctccccat 3481 cactcagcca cactcagnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnngta 3601 gaggagctgg aagccgagcg gggtgggagg agtggcggct gcgggcgagg acgcgcgcgc 3661 ctccgctcgc cctccagcgc gggcgggcag gacgagcgcc ggggagcggc ggttacgcgg 3721 ggccccgatc gctgtgggca ccaatcaacg gttgccatag cagcgtttga cgtcatcgtg 3781 cgtgtggtgc ccctgctgcc ggggctggtg attggaggaa accccgtgtc tgcggagcgg 3841 ctgtagcctg tgagcagcga gatccaggga cagagtctca gcctcgccgc tgctgccgcc 3901 gccgccgccc agagactgct gagcccgtcc gtccgccgcc accacccact ccggacacag 3961 gtgaggaacc cggccgccgc cgcgcctcgc ttcctgtccc aggnnnnnnn nnnnnnnnnn 4021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4081 nnnnnnnnnn nnnnnnnnnn nnnaggcagt taggtttcag gtttaaaaaa ctcatttacc 4141 acaggtataa ttttgagtct gtttattttg atgggaaaaa ttttaaatac tccttttttc 4201 ccccctgcag aacatccagt catggataaa aatgagctgg ttcagaaggc caaactggcc 4261 gagcaggctg agcgatatga tgacatggca gcctgcatga agtctgtaac tgagcaagga 4321 gctgaattat ccaatgagga gaggaatctt ctctcagttg cttataaaaa tgttgtagga 4381 gcccgtaggt catcttggag ggtcgtctca agtattgaac aaaagacgga aggtgctgag 4441 aaaaaacagc agatggctcg agaatacaga gagaaaattg agacggagct aagagatatc 4501 tgcaatgatg tactggtgag aatcaattca gtctggcttc attatactgt agggtcccta 4561 tgagtatcag ttacattact cttaactttt tgtttggttt ttcttttcct tctaaacatt 4621 gtgtgtnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnttat tctcactatg 4741 tctgtttctt ttcttcttaa gtctcttttg gaaaagttct tgatccccaa tgcttcacaa 4801 gcagagagca aagtcttcta tttgaaaatg aaaggagatt actaccgtta cttggctgag 4861 gttgccgctg gtgatgacaa gaaaggtatg ctgtttttaa acctgttggt tgaacttgta 4921 taagataaca tagtgaggaa gagtctctga agcgtacata atgtcttgtt ttgaattgct 4981 tagagtgccg aataaggagt agcagtgctc tttgtgttct gagaatacac atctactgcc 5041 tcatactgct attctaaaat aaatgctttc tgaaaagcca atattgtgta cagggatgtt 5101 ttttcaagat tttaagaaaa gtgaccagcc tgagcaacat ctctctctac aaaaaatatt 5161 ttgaaaatta gctgggcatg gtggtgcaag cctttggtcc cagctaatct ggaggctgag 5221 gtgggaggat tgcttgggtc tgggatgtca aaactcgtca attttttaaa aacataacaa 5281 taatgagatt ataaagttgt tttatcttga cattgatcaa tggctagtgt gtaccaggag 5341 aaagctccct ttaaaaaaaa aaaaggacct tgttcaatta acaaatatta agctgttaca 5401 ggttagtatt tcaaaggata tgtgagatat taaaggtttg gtttgagggg tgaagatata 5461 atgcacactt tatctcagta cgttttggtg tgtcttatcc agggattgtc gatcagtcac 5521 aacaagcata ccaagaagct tttgaaatca gcaaaaagga aatgcaacca acacatccta 5581 tcagactggg tctggccctt aacttctctg tgttctatta tgagattctg aactccccag 5641 agaaagcctg ctctcttgca aagacagtat gtattttacc tgttacgtag aaatttagca 5701 gtctttatta tttgagcact gaaatgtaat gtactatttt taaatcgtag gcttttgatg 5761 aagccattgc tgaacttgat acattaagtg aagagtcata caaagacagc acgctaataa 5821 tgcaattact gagagacaac ttgacagtaa gtacataaca gcatcattag tgatgaatgt 5881 ggttgaagag gttatgtttt actctaggga attttttttt ttattaaata catcttttaa 5941 aattttttct caacacattt cataggctct cataaatata tctcagctac tattaaagtc 6001 ctatgaagga aaattacaga aactgaaata ttagactgag aactaaaaaa tacacacatt 6061 gatgagttac ctgtcttgnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnca 6181 ttcaggtatc ttggcactta tatgaaaacg cccccccccc cccatcccac tgaaacttgc 6241 tgaaaaatct ttccttcttt taccagttgt ggacatcgga tacccaagga gacgaagctg 6301 aagcaggaga aggaggggaa aattaaccgg ccttccaact tttgtctgcc tcattctaaa 6361 atttacacag tagaccattt gtcatccatg ctgtcccaca aatagttttt tgtttacgat 6421 ttatgacagg tttatgttac ttctatttga atttctatat ttcccatgtg gtttttatgt 6481 ttaatattag gggagtagag ccagttaaca tttagggagt tatctgtttt catcttgagg 6541 tggccaatat ggggatgtgg aatttttata caagttataa gtgtttggca tagtactttt 6601 ggtacattgt ggcttcaaaa gggccagtgt aaaactgctt ccatgtctaa gcaaagaaaa 6661 ctgcctacat actggtttgt cctggcgggg aataaaaggg atcattggtt ccagtcacag 6721 gtgtagtaat tgtgggtact ttaaggtttg gagcacttac aaggctgtgg tagaatcata 6781 ccccatggat accacatatt aaaccatgta tatctgtgga atactcaatg tgtacacctt 6841 tgactacagc tgcagaagtg ttcctttaga caaagttgtg acccatttta ctctggataa 6901 gggcagaaac ggttcacatt ccattatttg taaagttacc tgctgttagc tttcattatt 6961 tttgctacac tcattttatt tgtatttaaa tgttttaggc aacctaagaa caaatgtaaa 7021 agtaaagatg caggaaaaat gaattgcttg gtattcatta cttcatgtat atcaagcaca 7081 gcagtaaaac aaaaacccat gtatttaact tttttttagg atttttgctt ttgtgatttt 7141 tttttttttg atacttgcct aacatgcatg tgctgtaaaa atagttaaca gggaaataac 7201 ttgagatgat ggctagcttt gtttaatgtc ttatgaaatt ttcatgaaca atccaagcat 7261 aattgttaag aacacgtgta ttaaattcat gtaagtggaa taaaagtttt atgaatggac 7321 ttttcaacta ctttctctac agcttttcat gtaaattagt cttggttctg aaacttctct 7381 aaaggaaatt gtacattttt tgaaatttat tccttattcc ctcttggcag ctaatgggct 7441 cttaccaagt ttaaacacaa aatttatcat aacaaaaata ctactaatat aactactgtt 7501 tccatgtccc atgatcccct ctcttcctcc ccaccctgaa aaaaatgagt tcctattttt 7561 tctgggagag ggggggattg attagaaaaa aatgtagtgt gttccattta aaattttggc 7621 atatggcatt ttctaactta ggaagccaca atgttcttgg cccatcatga cattgggtag 7681 cattaactgt aagttttgtg cttccaaatc actttttggt ttttaagaat ttcttgatac 7741 tcttatagcc tgccttcaat tttgatcctt tattctttct atttgtcagg tgcacaagat 7801 taccttcctg ttttagcctt ctgtcttgtc accaaccatt cttacttggt ggccatgtac 7861 ttggaaaaag gccgcatgat ctttctggct ccactcagtg tctaaggcac cctgcttcct 7921 ttgcttgcat cccacagact atttccctca tcctatttac tgcagcaaat ctctccttag 7981 ttgatgagac tgtgtttatc tccctttaaa accctaccta tcctgaatgg tctgtcattg 8041 tctgccttta aaatccttcc tctttcttcc tcctctattc tctaaataat gatggggcta 8101 agttataccc aaagctcact ttacaaaata tttcctcagt actttgcaga aaacaccaaa 8161 caaaaatgcc attttaaaaa aggtgtattt tttcttttag aatgtaagct cctcaagagc 8221 agggacaatg ttttctgtat gttctattgt gcctagtaca ctgtaaatgc tcaataaata 8281 ttgatgatgg gaggcagtga gtcttgatga taagggtgag aaactgaaat cccaaacact 8341 gttttgttgc ttgttttatt atgacctcag attaaattgg gaaatattgg cccttttgaa 8401 taattgtccc aaatattaca ttcaaataaa agtgcaatgg agaccttggg gtctttattt 8461 ccaggagaaa agataccttc tgcatctagg gcaacaatcc ttttccctcg cagctctttc 8521 ttttacctca cttactgatt tctcctgacc cccaagccaa ggaggtaaaa taattatata 8581 tatatatata tatatatata tatatatata aagtaattat attttatagc tagactgaag 8641 aggtgggaat ttttttgttg tttttttttt ttttggagac aagagtcttg ctctgtcacc 8701 caggcttgag tgcagtggtg cgatctcggc tgagtgcaac ctccgcctgc tgggttcaag 8761 cgattctcct gcctcagcct cccaagtagc tgggattaca ggtgcccgcc accacacctg 8821 gctaattttt gtgtttttag tagagacagg gtttcaccat gttgtccagg ctggtcttga 8881 attcccgacc tcaggcaatc cgcccatctc aacctcccaa agtgctggga ttacaggcat 8941 aagccaccgc gcccagtaga gatgtgatat tattcaagta aataaaacct gaaacttggc 9001 acatttgcct atttaatgtg catcagtcat ctgaactagg ttgatcctgg aataatgaaa 9061 acacttcact agtattaact aatgttttct acatagtagt tcccaataga ttaaggaaaa 9121 tttccaacct gagattcttt gttttggaat ttgaataatg tgtttgtaac tattccttga 9181 ttgtcccaaa tccaggcttt acgtctgctt ttgtcaatgt aacatcctag tgccaggaaa 9241 ttggaaaatc caatgacttt ttgtgtgtaa agtactggaa tttttttgtt cgtttgtttt 9301 taagacggag tgtcaactct cgcccaggct ggggtgcagt ggcctgatct cggctcactg 9361 caaccttctc ctcccaggct gaagtgattc tcctgcctca gcctcgcaag t //