LOCUS DUOL01000206 16178 bp DNA linear ENV 25-APR-2020 DEFINITION TPA_asm: Bacteroidales bacterium isolate AS08sgBPME_175 257795_AS08, whole genome shotgun sequence. ACCESSION DUOL01000206 DUOL01000000 VERSION DUOL01000206.1 DBLINK BioProject: PRJNA602310 BioSample: SAMN13893788 Sequence Read Archive: SRR2917896, SRR2917897, SRR2917898 KEYWORDS WGS; Third Party Data; TPA; TPA:assembly. SOURCE Bacteroidales bacterium (anaerobic digester metagenome) ORGANISM Bacteroidales bacterium Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales. REFERENCE 1 (bases 1 to 16178) AUTHORS Campanaro,S., Treu,L., Rodriguez-R,L.M., Kovalovszki,A., Ziels,R.M., Maus,I., Zhu,X., Kougias,P.G., Basile,A., Luo,G., Schluter,A., Konstantinidis,K.T. and Angelidaki,I. TITLE New insights from the biogas microbiome by comprehensive genome-resolved metagenomics of nearly 1600 species originating from multiple anaerobic digesters JOURNAL Biotechnol Biofuels 13, 25 (2020) PUBMED 32123542 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 16178) AUTHORS Campanaro,S. TITLE Direct Submission JOURNAL Submitted (28-JAN-2020) Department of Environmental Engineering, Technical University of Denmark, Bygningstorvet, Bygning 115, Kgs. Lyngby 2800, Denmark COMMENT The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ ##Genome-Assembly-Data-START## Assembly Date :: JUN-2018 Assembly Method :: Megahit v. 1.1.1 Genome Representation :: Full Expected Final Version :: No Genome Coverage :: 398.4007328485x Sequencing Technology :: Illumina HiSeq 2500 ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Date :: 04/10/2020 13:38:06 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 4.11 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region Genes (total) :: 1,872 CDSs (total) :: 1,832 Genes (coding) :: 1,824 CDSs (with protein) :: 1,824 Genes (RNA) :: 40 tRNAs :: 37 ncRNAs :: 3 Pseudo Genes (total) :: 8 CDSs (without protein) :: 8 Pseudo Genes (ambiguous residues) :: 0 of 8 Pseudo Genes (frameshifted) :: 5 of 8 Pseudo Genes (incomplete) :: 3 of 8 Pseudo Genes (internal stop) :: 0 of 8 CRISPR Arrays :: 1 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..16178 /organism="Bacteroidales bacterium" /mol_type="genomic DNA" /submitter_seqid="257795_AS08" /isolate="AS08sgBPME_175" /isolation_source="anaerobic digestion of organic wastes under variable temperature conditions and feedstocks" /db_xref="taxon:2030927" /environmental_sample /metagenome_source="anaerobic digester metagenome" /note="metagenomic" gene complement(142..2445) /locus_tag="GXZ40_07760" CDS complement(142..2445) /locus_tag="GXZ40_07760" /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="HHU47775.1" /translation="MVKFFTNKKVKITLLILSSLFVLSLILIVFLPKKSIIESVKRQI ATTFVYEYIPNQNIDVTTTEAYKKKDSLYLDFRKNYRFPIQIIGYNNFSDSSKIILIS EPPPKLEIDSLHSIFNKFTHQIEIKKHKIGYDGFVKDIVIILSNATNENIENLLKKLT KELFYSAYKPFTINLSQTEKKVFFSKSNLDYQITLSEFEEWFLNEQEEFTPYNDSTES LTIQEILSKKRVGVFFSKLPGFVAWSIDKHQDLLNQIENIRPFTLDADLILGAFSDSN TLVIIGREREATVQELPPLRIETITLLASITKKELSQSLDINDFLAGKMSNGHDWCPT YLSNELENTELGDLLTLTDIILKDWSESGTIKENYYRYPHPSYYPFDKPLFKKLGLNE LVYNWNTNDAMYAIDYDSVTIYTLNRTGSLPVSYFNSQERSYSIGAKYENRAYHYFAT LNNCDLARVVQYTALYQLFIDNNIQYSGNTHSVYPKNKPYLLLKPTLTLLEILENLSQ ADIDKISDSIARKHFNEIHKERILEQITKDEINYHFQTTDDNKIKIFDNFLKNYKREM ASEFNSIKRLLANLNEEDFKKLARQLAYPRGTSKYTKENYQIYLKSRTVNSLLRSIGK NNLPLLGVDLKNIKDYFSNSLNQNSAKYLKTPSLIITFNDFYTTGGHNLSSKISRVKN SNHYKRNYGTGGDFPRSESTPPPISEKPKSPTASSPRPTTSTAKKGSSSSTGKETQKK QTTTKSSTTARSRGSVISNSPRTQRGF" gene complement(2464..3192) /locus_tag="GXZ40_07765" CDS complement(2464..3192) /locus_tag="GXZ40_07765" /inference="COORDINATES: protein motif:HMM:NF016837.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="nicotinamide mononucleotide transporter" /protein_id="HHU47776.1" /translation="MKKETQVLLKGVLKNSLIAILIFSIVLVFLFLVGLKDNIKGIAI ASGIVGSAYILTIRNPNNYFGFYLGILSSILLGIQFYLIDNFELFFVYFFIFIPSQAI SIYTWKKGNKQDGLSSELNPSFLSFRNFLIVTACFLLLFIADIFIAREVSHAPQVSLS IQIFSAIFVAASILANILLIKKKTDSWYYWFIFSIAGIILNILYKDYVTVTLFVIYLL INSEAGLMWIKKTPKENYGWLKGK" gene 3430..4008 /locus_tag="GXZ40_07770" CDS 3430..4008 /locus_tag="GXZ40_07770" /inference="COORDINATES: protein motif:HMM:NF012655.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="TetR/AcrR family transcriptional regulator" /protein_id="HHU47777.1" /translation="MSKKTKDTIIQVASKLFSRYGFYKTSMDEVAKVARKAKGSLYYH FVNKEGLFKEVVARELEFVKSELTKILSITNLPATQLMKIFLRKRMELLANSFNYHEI LKADLHEHFSFLDDVRVDFAKWEKEQFKFIILKGIEEGLIDKNLNYDVAIDVFILILK SSEIQFFVQNRYDEFAPHFDELIEIVIRGIKA" gene 4063..6324 /locus_tag="GXZ40_07775" CDS 4063..6324 /locus_tag="GXZ40_07775" /inference="COORDINATES: protein motif:HMM:NF015155.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="RND family transporter" /protein_id="HHU47778.1" /translation="MKKTLSYIIKFRTLILLTILAITLVMGWQMKNLKINSDIISSLP DDDPAAVLYKEIGEKYQGSTIGIIIVNSENLYSAQTIADVATITDIVQSTKGVESVTS LANIINIKTDEYGLEVGNLVDIYALPETEEELMNLKNEVESNEMYKGVIVSNDGKSTI VMFTLATDVNQEEVGKEIKEKIAAQNFSHGITYGGLPMMMQELSTIIFNDMLWLIPSV AILLLIILFLSFKSVRGTILPLITVSIAITWTLGLMAILGYDITMIGGIIPVILFAVG SAYSIHVINHIRENQEEDYRKRILSSLGYLVLPVFLSSLTTVFGFVSFIFGSYLTMIK DFGIFCAVGTFFSFILALTFIPALISFFPTPPRRVSDKESLLTKKFLRPLSSLVLKYP KYVLIFWISLVILGIIGTFKIDRSTNLASFFNKKSETRIAEETLQEQFGGSAPVYVLF KGDVHDPDFLAKMGDFSDFLKTNPHISHVTSIVDLIEQMNEAMGEGRKLPTDRAKIEQ LWFLLEGHEVMEQLVSDDLDEAIIQTRFSSINTNDTKKFIDEVEEYITAHQDENVTIQ LSGIPSVYVNMDSSLLKSQLSSLSIAIVLVLLLISISLRSLKLGIMGIVPILVTVSAV FGFMGFTGISLDVATVSVASIVLGIGIDYSIHTISSFNYYFKIKNDIDYAIKNTICII GKSIMINATAVGLGFSVLLFSHLIPMKFMGLLIAISMLLSSIGALTLLPIMIIINHNY KNKLLTKKQLKTA" gene 6326..7054 /locus_tag="GXZ40_07780" CDS 6326..7054 /locus_tag="GXZ40_07780" /inference="COORDINATES: protein motif:HMM:NF028441.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="outer membrane lipoprotein-sorting protein" /protein_id="HHU47779.1" /translation="MKKIRLITQIFLIMFLMGHVNAQTGTEILKKMDEIMFSAKDLSA TNKIVIIDKNGKQDVREATIIQKGDEMRLLRFTSPASQAGIAMLSLPNDVMYIYMPAF AKERRISSSVKNQKFAGTDFSYDDLQAQPFSEKYTAELSKTTSDSYILELKPKKAGEY SRILLTINKTEYYPISTEFYDKSNTKIKESKYTFEKVGKYWSPAQIEMNDLKKGSKTK IQMLNPKYDQGLSDSEFTVRKLTN" gene 7056..8444 /locus_tag="GXZ40_07785" CDS 7056..8444 /locus_tag="GXZ40_07785" /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="HHU47780.1" /translation="MKKVFSSILVVLFFCNIVWAQENQPLKIFGSLSTDQRIITGKES EWAWNENRLSLKLEKKVNRGKLYGEIWVRNFGVPNFTNVEHLYNRGIVDPFDVQVREA YFQISDLFIPNLDLKIGRQRIAWGSADQMNPTDNLNPHDLEDILDFGRHRGSDAINLT YYIKNDFSIQAVFIPFFQPANLPVGVFADAIFPSFELPADTNVKINEIRTVIKKPALK FGTNSTVGFKFKAFVKTVDFSLSYVYGYDGLPFLTKKTVIPIDPIIYPWTWRIDVEAE LSYVRQHILGLDFSTNIKGVGVWGEAALFMLGDDVRDSTIVNSILPLIPPEVTDSIVL NRKKPFLKFIIGADYHFGKSSYINVQYMHGFIHERGAKELSDYLFLRYDFRLLNDRLY LAPISGAVIISDWKEVKNNYALVYMPQISYYPIPEVELSLSYIWLNGKGEGLFSKIQD YDMFLIKAKFAF" gene 8508..8717 /locus_tag="GXZ40_07790" CDS 8508..8717 /locus_tag="GXZ40_07790" /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="HHU47781.1" /translation="MREGAAGKPARAEAAGDAAAKKRACKLFLPLCVPTACDRGLAGE DRPLSAAKGARPKKEKKSKEIRELF" gene complement(8692..9453) /locus_tag="GXZ40_07795" CDS complement(8692..9453) /locus_tag="GXZ40_07795" /inference="COORDINATES: protein motif:HMM:NF012451.1,HMM:NF016955.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="DnaJ domain-containing protein" /protein_id="HHU47782.1" /translation="MFKFIGALIGVISGGFWGALLGYIIGSFIDNLRRKRYRVTYHHT TPNDFTHSLLVFIAAVVKSDNRFLKSELYFVRDFLVKNLGPTAASNALLELREILKED YNIEDYCYLFRQRSSIHERFLIIQFLLGLAGADDYYGAEEVAMIDKIAHWFGINPIDY ASLKAMYIGGYSRQSSSYSPPSTSTNLENDYKVLKIKETASDAEVKKAYRKLAQEYHP DKVNHLGEDMRKAAEDKFTKLNQAYERIKKARGFL" gene complement(9446..10741) /gene="rimO" /locus_tag="GXZ40_07800" CDS complement(9446..10741) /gene="rimO" /locus_tag="GXZ40_07800" /EC_number="2.8.4.4" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_008582726.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="30S ribosomal protein S12 methylthiotransferase RimO" /protein_id="HHU47783.1" /translation="MKQSINLITLGCSKNIVDSEIIAAQFEQLGYKVYHETEDDTDII IINTCGFILDAKEQSIETILFFLEKKQKESKLFVIGCLAERYKKELEETLPEVDGFYG FSELSNFFDLFKIPPFNLLHPTHRLLSTPSHYAYLKISEGCDRQCAFCAIPTIRGKHI SKPKELLITEAKTLVEKGVKEIMLIAQDLTYYGIDLYKKRSLASLLQELAQIKGLEWI RLHYAYPVNFPYEILDVINDYKNICRYIDIPFQHINDNILKTMRRGHTASDTYQLIET LRSKIPHIAIRTTLISGFPGETKKEHNQLLKFIEEARFERLGIFSYSQEENTPAYSLG DPINKKEKKRRLDELMLLQQEISYELNQEKINSTLKVMIDDENDNFYLGRTEFDSPEV DNGVLIDKEEKLEIGNFYNARIIDANTFDLVGKIAKEYV" gene complement(10759..11955) /locus_tag="GXZ40_07805" CDS complement(10759..11955) /locus_tag="GXZ40_07805" /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="HHU47784.1" /translation="MKKFSLLAAISLLMMVTTIAQPCISDAWMNLQNKQISKAKRVID ACQVGNENNADYWLMKANVYLQRYEEEKSRLEKNPKYVIKDTDAIWIANECFYKAVEI DPKVTPKSGLIDPIMGQMLCAGPFYDMGYEAYKKDNWQKAFKYLYAAVRALKLDDKNP SLPRDLGYIYFDLSQIARKLEQPDTYKKMLTEAVAIKTPIPEIYILLYDLYKEEKDTV KCANVIKSAKKHVPANGLIKIYELELEHLTMSGEQEKFIALADKLAEENPENISLLAK LALYMTNNDQFEKAETYLKQGLAIDSSNFELNQQMGYRYFFEAIKYQNLMDQATNDKD WNKLKELREAEKNILELAHTWVEKAYLINNDDRGNNIMLQQLKVKLLKEIPEELKEKI DSYKHD" gene complement(11978..13168) /locus_tag="GXZ40_07810" CDS complement(11978..13168) /locus_tag="GXZ40_07810" /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="HHU47785.1" /translation="MKQLKITLILLTVLLSVDAQKPSLSRAYNFYYDQNYVKAKEIID LCIKDEKLSLKATTWLYKANIDYYLASNEYSERQKDDNYNIRFPQTPVEAYDAFKKAK ELNKNVVATGMLSPDNALPQLYTLLFINGVDELIAQKYVEAKETLEKGIESYEMNKIP PYPLNGEIYYYYAYTLEVLKDKQNAIRNYEKAIIDSSRNANVYLRLIALHKEVNNNEA IYSTIDKGRKFLPNNPDIAVAEADYYFFTKDTVKAKEILYQLPIEHFDDINTIINVSN LFILDSNYTQAEKLLKKAYRQNQDNFVVLYNLGVTCYYISEQNFIKANQLQVQGNKNA AEPLKEVSDKYLEEAKNYFEQALHIQPDDLSVLNVLKAIYIRMDSPKYDETLKKIEQL ENKK" gene complement(13221..15734) /gene="gyrA" /locus_tag="GXZ40_07815" CDS complement(13221..15734) /gene="gyrA" /locus_tag="GXZ40_07815" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_013688013.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="DNA gyrase subunit A" /protein_id="HHU47786.1" /translation="MIGEEKIISVNIESQMKKAYIDYSMSVIMSRALPDTRDGFKPVH RRILYAMYDMGITSSKPHKKSARIVGEVLGKYHPHGDTAVYDSMVRMAQDWSLRYPFV DGQGNFGSIDGDSPAAMRYTEARMRKIAEEMLEDIKKETVDFRTNFDDSLEEPTVLPG KIPNLLINGASGIAVGMATNMAPHNLSECCDGITAYIDNNDITVEELMQYIKAPDFPT GCTIYGYDGVKEAFETGRGRVVLRGDATIEEVNGKTQIIVTSIPYLVNPSDMIKRTVE LVKEGKIDGISNIEDLSNRRNGTQIVYELKREAIPNIVLNKLYQYTALQASFNINNVA LVNGRPMTLNLKDLIKQYVKHRHDVVVRRSQYDLRKAQERAHILEGYLKALDFIDEII ALIRASATPEDARIGLMEKWQFTDIQARAIIEMRLRQLTGLEREKLQNEYDELQKLIE YLNRVLAEESLRMQIIKDELNEVKQKYGDERRSRIEFSATDFKIEDTIPDTEVVITIS HLGYIKRTSSSEYKVQNRGGKGSRGGSSRDEDFIEHLYIATNHNYLLFFTEKGKCFWL RVYEIPEGSKTSKGRAIQNLLNIESDDKIKAVINVHDLTDDEYINNNYIILCTEKGII KKTSLEAYSRPRVNGINAITIRENDHLLEAKLTNGENEIMLALNSGKAVRFNEKNVRP MGRNASGVKGITLANDDDFVVGMICIDNPDQTILVVSENGFGKRSLLDDYRITNRGGK GVKTISITEKTGGLIAIENVTDNDDLMIINRSGLTIRLHVDTLRIMGRATQGVKLIEL NTDDQIAAVTCVPKEEPDDDEEEDNVTENNDTTTENLEE" gene complement(15977..>16178) /locus_tag="GXZ40_07820" CDS complement(15977..>16178) /locus_tag="GXZ40_07820" /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /codon_start=2 /transl_table=11 /product="hypothetical protein" /protein_id="HHU47787.1" /translation="AAKKRACKLFLPPCVPTACARGLGTGRRPVSVSERDTPKRKLQL FLYSSFLHIFVIDKKQRNNIYS" BASE COUNT 4870 a 2707 c 2989 g 5612 t ORIGIN 1 atggaaaatt gatttttttg ataaaattct ttcgcaagct cttcgccttt tttccccaat 61 tcagagcgat tttgtactat cataacgtta attttttact aatataacgt taattatttg 121 tttatatttt aagtgattcg actaaaaacc gcgttgcgtt ctgggcgaat tggatatcac 181 acttcctctg cttctcgccg tagtcgaaga ttttgtcgtt gtttgttttt tttgtgtctc 241 tttgcccgtg cttgatgaac tccctttttt tgcagtcgaa gttgtcgggc gaggtgagga 301 ggcagtcgga cttttcggtt tttccgaaat tggtggaggt gtgctttcgg aacgtggaaa 361 atcaccgccc gttccgtaat ttcgcttata atgattactg ttttttactc tactgatttt 421 agaagataaa ttgtgcccgc cggttgtgta aaaatcatta aatgtaataa ttagtgacgg 481 cgtcttaaga tattttgcac tattttggtt caaactattt gaaaaataat cttttatatt 541 ttttaagtca acgcctaaaa gaggtaagtt gtttttccca atgctacgaa gaagtgagtt 601 tacggtgcgg cttttgagat aaatttggta gttctctttg gtatacttgc ttgttcctcg 661 tggataagct aattgccgag ctaatttttt aaaatcctct tcgttaagat ttgctaataa 721 cctttttata ctgttaaatt ccgaagccat ttctcgtttg taatttttaa gaaagttgtc 781 aaaaatcttt attttattgt catcggttgt ttgaaaatgg taattgattt cgtcttttgt 841 tatttgttca agaatcctct ctttgtgtat ctcgttaaaa tgttttcgag caatagaatc 901 tgaaattttg tcaatatccg cttgagaaag attttcaagg atttctaata aagttagagt 961 cggttttagt aataaatagg gcttattttt cgggtaaaca gagtgggtgt taccggaata 1021 ttgaatgtta ttatcaataa atagctgata tagagcagta tattgcacga cacgtgccaa 1081 atcacagtta tttagtgttg cgaaatagtg atatgcccga ttttcatatt ttgctccaat 1141 cgagtaactc ctttcttgtg agttgaaata ggaaacgggc aatgagcctg tgcgattgag 1201 tgtgtaaatg gtaaccgaat cataatcaat ggcatacatg gcatcattcg tattccaatt 1261 gtaaactaat tcatttaagc ctaatttttt aaataacggt ttgtcaaagg gataataaga 1321 agggtgcggg tagcggtagt aattctcttt aatcgttccc gattccgacc aatctttgag 1381 aataatatcg gtcaatgtaa gtaaatcgcc caattccgta ttctctaatt cgttactcag 1441 atatgtcggg caccagtcat gcccgttact catttttccg gctaaaaaat cgttaatatc 1501 taaactttgt gaaagctcct ttttagttat tgacgctaat aaggtaatcg tttcaatacg 1561 caaaggcggc aattcttgaa cggttgcttc tctctcacgt ccaatgataa ctaaggtatt 1621 gctatccgaa aatgctccta atatcaagtc ggcgtcaagg gtaaagggac gaatgttctc 1681 aatctgattc aataaatctt ggtgcttatc aatagaccat gctacaaagc ccggtaactt 1741 gctgaaaaaa acaccgactc tttttttcga taaaatttct tgaatggtaa gagactcggt 1801 agaatcattg taaggagtaa actcttcttg ctcgtttaaa aaccactctt caaattcaga 1861 aagtgtaatt tgataatcta agtttgattt agaaaagaat actttttttt cggtttgaga 1921 taaatttatt gtaaagggct tatatgccga ataaaacaat tcctttgtca atttttttaa 1981 tagattttca atattttcat tcgtagcatt agagagaatt atcacgatat cttttacaaa 2041 accgtcataa ccgattttat gtttttttat ctcaatttga tgagtgaatt tattaaagat 2101 agagtgtaat gaatcaattt ccaattttgg tggaggttct gaaattagaa taattttgct 2161 gctatcggaa aaattattgt aaccgataat ttgaattgga aatcgatagt tttttctaaa 2221 gtcaagataa agtgaatctt tctttttata ggcttcagtc gtagttacat caatattttg 2281 gttcgggata tattcataaa caaacgtggt agcgatttgt cgttttacac tctcaataat 2341 gctttttttg ggcaaaaaaa cgatgagaat aagagataaa acaaaaagag atgaaagtat 2401 taaaagagtt atctttactt ttttgttagt gaaaaatttt accataaaat tacttatatg 2461 gaactacttt ccttttaacc aaccataatt ctctttggga gttttcttaa tccacatcaa 2521 tccggcctca gaatttataa gtaaataaat cacaaaaagt gttacggtta cataatcttt 2581 gtaaagaata tttaaaataa tccctgcaat actaaatata aaccagtagt accacgagtc 2641 ggtcttcttt tttatcaata aaatattagc caagatactt gctgcaacaa aaatggcact 2701 gaaaatttgt attgataaag agacttgcgg agcgtgtgag acttctctgg caataaaaat 2761 atctgctata aatagtaaca aaaaacaagc ggtaacaatc aggaaatttc taaatgataa 2821 aaatgacgga tttaattcag aggaaagtcc atcttgtttg ttcccttttt tccacgtata 2881 tatggaaata gcttgcgaag gaataaaaat aaaaaaatag acgaaaaata gctcgaaatt 2941 atctattaag taaaactgaa tccctaataa aatagaagag agtataccaa gataaaaacc 3001 aaagtaattg ttcggattcc tgatggttaa tatataagca ctccctacaa tcccactggc 3061 aatagcaata cctttgatat tgtcttttaa gccgacaaga aatagaaaaa ccaatacaat 3121 actaaatatg agaatagcta taagtgagtt ttttaaaact ccttttaata aaacttgcgt 3181 ctcttttttc atggatttga atagttttag agttaataaa taatgagtta caaataaatg 3241 aaaatacaat gagggtgcaa aaatacgaaa tttaatgaat tagaccgatt tttcatctaa 3301 aattttttta aggattttta agattttaat gctattataa tataaaataa aattgtattt 3361 ttgtaccaaa aaacgaaaat agtcataaaa tacatgatat tatattgtat aattaaaaaa 3421 aaagatagaa tgagtaaaaa aacgaaagat actatcattc aagttgcttc aaaacttttt 3481 agtagatatg gcttctacaa gacttccatg gatgaagtag ccaaagttgc tcgtaaagcc 3541 aaaggttcgc tctattatca ttttgttaat aaagaaggac tttttaaaga ggtggttgcc 3601 agagaattag agttcgtaaa atcggaactg acaaagattc tctctattac aaaccttccg 3661 gctacccaac taatgaaaat atttttaagg aaaaggatgg agcttcttgc taattctttt 3721 aattaccatg aaatattaaa agcagatttg catgaacatt tttcttttct tgatgatgtt 3781 cgtgtggatt ttgcaaaatg ggagaaagag caattcaaat ttattattct taagggtatt 3841 gaggaagggc taattgataa gaatttgaat tatgatgtgg ctattgatgt atttatatta 3901 atacttaaaa gctcagaaat acaatttttt gttcaaaatc gatatgatga gtttgctccg 3961 cacttcgatg aactaataga aatagtgatt cgaggcataa aagcttaatt tttttttgat 4021 ataacttgac tttaaaacaa taatagtata aaactctaaa aaatgaaaaa aacactttcc 4081 tacattatta aatttcgcac tctcatttta ctgactattc tcgctattac gttagttatg 4141 gggtggcaaa tgaaaaactt gaaaataaat tccgatatca taagttcgct accggacgat 4201 gatcctgcag cggttttata taaagagatt ggtgaaaagt atcaaggaag taccattgga 4261 attattattg tcaattccga aaatttgtat tccgcacaaa cgattgcaga tgtcgccacg 4321 ataaccgata ttgttcaaag cacgaaaggg gttgaaagcg ttacaagttt ggcgaatatt 4381 atcaatatta aaaccgatga atatggctta gaggttggta atttagttga tatctatgcc 4441 ttaccggaaa cggaagagga gctgatgaat ctaaaaaacg aagttgagag taatgaaatg 4501 tacaagggtg ttattgtttc caatgacggt aaatcaacca ttgtcatgtt tacactggct 4561 acagatgtta atcaggaaga agtgggtaaa gagataaaag aaaaaatagc tgctcaaaat 4621 ttcagtcatg gtattactta tggtggtctg cccatgatga tgcaagaatt gtcgactatt 4681 atttttaatg atatgttatg gctaattcct agtgtagcta ttcttttact aattatatta 4741 ttcctcagtt ttaaatcggt aagaggtact atattgcctt taataactgt ttctattgcg 4801 ataacgtgga cgctgggctt aatggcgata cttggttatg atattacgat gattggtggg 4861 attattcctg ttatcctatt tgctgtcgga agtgcttatt ctatccacgt cattaatcat 4921 attcgagaaa atcaggaaga agactaccgt aaacggatat tatcatcgtt aggatatttg 4981 gttttacctg tatttttatc ttctttaact accgttttcg gttttgtatc ttttatcttt 5041 ggttcatatc tcacgatgat taaagatttt gggatttttt gtgccgtagg gacttttttc 5101 tcttttatat tagctttaac atttattcct gcactaatct ctttctttcc cacgcctcca 5161 cgtagagtat cggacaagga gtcgttgtta accaagaaat ttttgcgtcc tctaagttcc 5221 ttagtgctta aatacccgaa atatgttctt atattctgga tttcgttggt aattctgggt 5281 attatcggaa cttttaaaat tgatagaagt acgaacttag cctccttctt taacaaaaag 5341 agtgaaactc gtatagcaga agagacttta caggaacaat tcggaggctc tgctcctgtc 5401 tatgttctct tcaaaggtga tgtacacgat cctgattttt tggctaaaat gggcgacttt 5461 tcggatttcc ttaaaacaaa tcctcatatt tcacacgtta cctccattgt tgatttaatt 5521 gaacagatga atgaggctat gggcgaggga cgtaaattgc ctacagaccg agcgaaaata 5581 gaacaactat ggtttttatt ggagggacac gaagttatgg aacaattagt ttccgatgat 5641 ttagacgaag caattataca aactcggttc tcttctataa atacaaatga taccaaaaaa 5701 tttatagatg aagtagaaga atatattact gctcaccaag atgaaaatgt tacgattcaa 5761 ttaagcggaa ttccttcagt ttatgtaaat atggatagta gtttgttaaa aagtcaattg 5821 agtagtcttt cgatagctat tgtcttagtt ttacttttaa taagtatatc gttaagatct 5881 cttaaattgg gtattatggg gattgttcct attttagtaa ctgtgtcagc ggttttcgga 5941 tttatgggct ttaccggaat ttcacttgat gttgctacgg tttctgtagc cagtatcgtg 6001 ttaggtattg gaatcgacta ttcgattcat acgatatctt cttttaatta ctattttaaa 6061 attaaaaatg atattgatta cgctataaaa aatacaattt gtattattgg taaatcaatt 6121 atgattaacg ccacagcggt tggtctagga tttagtgttt tgctcttttc gcatctaata 6181 ccgatgaaat ttatgggatt attgattgcc atatctatgt tactttcgtc aataggagca 6241 ctcactctat tgccgataat gataattatt aatcacaatt ataaaaataa attattaacc 6301 aaaaaacaat taaaaacagc ttaaaatgaa aaaaatacgt ttaattactc aaattttcct 6361 catcatgttt ttgatgggac atgttaatgc acaaaccgga acggagatat taaaaaaaat 6421 ggatgaaatt atgttttcag ccaaagattt gtccgcaact aataaaattg taattattga 6481 taagaacggc aagcaagatg ttcgcgaggc gactatcatt cagaaaggag atgagatgcg 6541 tttattacgt tttacatcgc ccgcgtcaca agcagggatt gccatgcttt cgttgccgaa 6601 tgatgttatg tacatttata tgcctgcttt tgcaaaggag agacgaattt ccagtagtgt 6661 taagaatcag aaatttgcag gaacggattt ttcgtatgat gacttacaag cacagccatt 6721 tagcgaaaaa tatacggctg agctgtcaaa aacgacttca gacagctata ttttagagtt 6781 aaaacctaaa aaggcagggg agtactcaag aattctttta acaatcaata aaacggagta 6841 ttatccgatt tcaaccgagt tttatgataa aagcaatact aaaataaaag agagtaaata 6901 tactttcgag aaagttggaa aatactggtc gccggcgcaa attgagatga acgatttgaa 6961 aaaagggtcg aaaacaaaaa ttcagatgtt aaatcctaaa tatgaccaag gattaagtga 7021 tagtgagttt actgttagaa aattaaccaa ttaagatgaa aaaagttttt tcttcgatat 7081 tagtcgtcct attcttttgt aatattgtct gggcgcaaga gaatcagcca cttaaaattt 7141 tcggttctct aagtactgat caacgaatca ttaccggaaa ggaatcggag tgggcatgga 7201 atgaaaatcg actctcttta aaattagaaa agaaagttaa tcgaggaaaa ttatacggtg 7261 aaatttgggt tagaaatttt ggggtcccta attttacgaa tgttgaacat ctttataacc 7321 gaggaattgt tgacccattt gacgtacaag tgcgggaagc atatttccag ataagtgatc 7381 tttttattcc taatttggat ttgaaaattg ggagacagcg gatagcgtgg ggcagcgctg 7441 accagatgaa cccgactgat aatctgaacc cccacgactt agaagatatt ttagattttg 7501 gacggcaccg cgggtcggac gctatcaatt tgacttatta cattaaaaat gacttttcta 7561 tacaagccgt ttttattcct ttttttcaac ctgccaatct gccggtcggc gtttttgccg 7621 atgccatttt tccgtccttt gagctccctg cggacactaa tgtgaagatt aatgagatta 7681 gaaccgttat taagaagccg gctttaaagt tcggaactaa ttcaacggta ggattcaaat 7741 ttaaagcttt tgttaaaaca gttgactttt cgttaagcta tgtctatggt tatgacggct 7801 tgccattttt aacgaaaaaa acggtaattc ctatagatcc gattatttat ccttggacat 7861 ggagaataga tgttgaagcg gagttgtctt atgttcgtca acacatattg ggtttagatt 7921 tttctacgaa tataaaaggt gtaggcgtat ggggcgaagc ggctctattt atgctcggtg 7981 atgacgtgcg agatagcacg attgttaata gtattttacc attaattcct cccgaagtta 8041 cggattccat agtccttaat aggaaaaaac cgttcctgaa atttataatt ggagccgatt 8101 atcattttgg gaaatcaagt tatattaatg tgcaatatat gcacggtttt attcatgaaa 8161 gaggtgcaaa agagttgagt gattatctgt ttttacgtta tgatttcaga ttgttaaatg 8221 accggctcta tttagctcct ataagtggtg ccgtaataat tagcgactgg aaagaggtga 8281 aaaataatta tgccttagtt tatatgcctc aaatatccta ctatcccatt cccgaggtgg 8341 agttgtcgct ttcctatatt tggcttaacg gtaaagggga agggcttttt tcaaaaattc 8401 aagattatga catgttctta atcaaagcaa aatttgcatt ttaagaatga tatttccatt 8461 ctgcactccg actcgtcttt caaatatctc tgtatgagca agttggcttg cgtgagggcg 8521 cagccggaaa gcccgcaagg gcggaagccg ctggggacgc ggcggcaaaa aagcgagctt 8581 gtaagctctt tttgccgctt tgcgtcccca cggcttgcga ccgcggactt gcaggcgaag 8641 accgacccct gagcgcagcg aagggggcac gccctaagaa agaaaaaaaa tctaaagaaa 8701 tccgcgagct tttttaatac gctcgtaagc ttgattaagt ttagtaaatt tatcttcggc 8761 agcttttctc atatcttctc cgagatggtt tactttgtcg gggtgatatt cttgtgccaa 8821 cttgcgataa gcctttttga cctcggcgtc gcttgctgtt tcttttattt ttaaaacttt 8881 atagtcattt tctaaatttg tacttgtact tggcggggaa taggaggaac tttgtcttga 8941 atagccgcca atatacatcg ctttaaggga ggcataatca ataggattaa taccgaacca 9001 atgggcaatc ttatctatca ttgcaacctc ttcagcaccg taataatcat cggcgcctgc 9061 cagtcccaag agaaattgaa taattaaaaa tcgttcgtgg attgatgaac gttggcggaa 9121 taggtagcaa taatcttcaa tattataatc ttcttttaaa atctctctta gctctaaaag 9181 tgcattactt gccgccgtag gacctaaatt tttcactaaa aaatctcgta caaagtataa 9241 ttcggatttt aaaaatctat tgtcagattt cactaccgct gcaataaaca ctaacaagct 9301 gtgtgtaaag tcgttaggag ttgtgtggtg atatgttact ctatatcttt tcctacgtaa 9361 gttatcaata aaagaaccga tgatatagcc taaaagtgct ccccaaaagc caccactgat 9421 tacgccaata agagctccaa taaatttaaa catactcttt agctattttc ccaactaagt 9481 cgaaagtatt ggcatctatt atgcgggcat tgtagaagtt cccgatttca agtttctctt 9541 ctttatctat taaaacgccg ttatctactt ctggggaatc aaattccgtt cttcccagat 9601 aaaaattatc attttcatca tcaatcatta ctttgagtgt cgaattaatc ttttcttgat 9661 ttaattcgta agagatttcc tgttgaagta acattagttc atcaagacgt ctcttttttt 9721 cctttttatt gatagggtcg ccaagcgaat aggcgggagt attttcttct tgcgaatatg 9781 aaaagatgcc aagtcgttca aatcgagctt cttctataaa tttcagcagt tgattgtgtt 9841 ctttttttgt ttcgcccggg aaaccggaaa ttaatgtcgt tctaattgca atatgtggga 9901 tttttgaacg tagtgtttca attagctgat aagtgtccga ggctgtatgt cctcgccgca 9961 ttgtttttaa aatgttgtca ttaatatgtt gaaatggaat atcgatatag cgacaaatat 10021 ttttataatc gttgattaca tcaaggattt cgtaaggaaa attaacgggg taggcataat 10081 gaagacgtat ccactctaag ccttttattt gagctaattc ttgcagaagc gaggctaaac 10141 ttcgtttttt atataaatct attccataat aggtaaggtc ttgagcaatg agcataatct 10201 ctttaacccc tttctccact agtgtttttg cttcggttat cagtaattct ttgggcttag 10261 agatatgttt tccgcgaata gtcgggatcg cacaaaaggc gcattgtcgg tcgcaacctt 10321 cggagatttt gaggtaggca tagtgcgagg gggttgagag taggcggtgc gtggggtgaa 10381 gaaggttaaa agggggaatt ttaaataaat cgaagaaatt tgacagttct gaaaatccgt 10441 aaaatccatc aacttccggc agagtctcct ccaactcttt tttataacgt tcggctaaac 10501 agccaatgac aaataattta ctctcttttt gtttcttttc aagaaagaat aagattgttt 10561 cgatagattg ttcttttgcg tctaaaataa aaccgcaagt attaataatg ataatatcgg 10621 tatcatcttc agtttcgtgg tataccttgt agccaagttg ctcaaattgt gcagcaataa 10681 tttcagaatc gacaatgttt ttagaacagc cgagcgtgat aagattgata ctctgtttca 10741 ttatgagtat agtagtgttt aatcgtgctt atatgaatca attttttctt tgagttcttc 10801 agggatttct tttaaaagtt taacttttaa ttgttgaagc atgatattat ttcctctatc 10861 atcgttatta attaaatatg ctttttctac ccaagtatga gctaattcaa ggatattctt 10921 ttcagcttcc cttaactctt ttagcttatt ccaatctttg tcattggtcg cttggtccat 10981 taaattttga tatttaatag cttcaaaaaa gtaacgataa cccatttgtt gatttagttc 11041 aaaattagaa gagtcaatgg caagtccttg tttaagataa gtttcagctt tttcaaactg 11101 atcgttattt gtcatataaa gagctaattt agcaagcaga gagatgtttt caggattttc 11161 ttctgctaat ttatctgcga gagcaataaa tttttcttgc tctccactca ttgtcaaatg 11221 ttctagttct aactcgtaaa ttttaataag tccattggcg gggacatgtt tttttgctga 11281 tttaataaca ttagcacatt taacggtatc tttttcttct ttgtacaagt cgtagagtaa 11341 gatatagatt tccggaatag gagttttaat ggcaacagct tcggtaagca ttttcttata 11401 ggtatcgggt tgttctaatt tacgagcaat ttgggacaaa tcaaaataga tataacctaa 11461 atctcttggt agcgaagggt ttttgtcatc taatttcaaa gctcttactg ctgcgtaaag 11521 atatttaaaa gccttttgcc aattatcttt tttatatgct tcatatccca tgtcgtaaaa 11581 gggaccggca caaagcattt gtcccataat tgggtcaata agtccggatt taggagttac 11641 tttaggatct atttcaacgg ctttgtagaa gcactcatta gcaatccaaa tagcatctgt 11701 atctttaatg acatattttg gatttttttc caatctactc ttttcttctt cgtagcgttg 11761 gaggtaaaca ttcgctttca taagccagta gtcggcatta ttctcatttc ctacttgaca 11821 agcgtcaata actcttttag ctttactaat ctgtttattt tgaaggttca tccaagcgtc 11881 agaaatacaa ggttgcgcta tagttgttac catcattagc agactgattg ctgctagtaa 11941 actaaatttt ttcattttac attgatttta ataaaaatta ttttttgttt tctaattgtt 12001 caattttttt aagtgtttca tcatactttg gagaatccat acgtatgtaa attgctttta 12061 gcacattaag cacagaaaga tcatcaggtt gaatatgtaa tgcttgttca aaatagttct 12121 ttgcttcttc taaatactta tccgatactt cttttaacgg ttctgcagcg tttttatttc 12181 cttgaacttg taattgattc gcttttatga agttctgttc ggaaatatag tagcaagtta 12241 cgccaagatt atagagtaca acaaaattgt cctgattttg tcgatatgct tttttaagta 12301 atttttcagc ttgcgtataa ttggaatcta aaataaaaag atttgaaaca ttaatgatgg 12361 tattaatatc atcgaaatgc tcaattggaa gttgatacaa aatctcctta gcttttaccg 12421 tatctttagt aaaaaaatag taatcggcct cggcaacggc aatatcagga ttgttgggga 12481 ggaatttccg tcctttatca atcgttgaat atatagcttc gttattgtta acttctttat 12541 gtagagcaat aaggcggaga tagacattgg catttcgtga gctatctatg atggctttct 12601 cataatttct tattgcattc tgcttatctt taagcacctc aagtgtataa gcatagtaat 12661 agtaaatttc gccgttaaga gggtagggag gaattttatt catttcatag ctttcaattc 12721 ctttttctaa tgtttctttg gcttccacat acttttgtgc gattaattca tcaacgccgt 12781 ttataaacaa taatgtataa agttgtggta gagcattatc cggagatagc attcccgttg 12841 caacaacatt tttattaagt tccttagcct ttttgaaagc atcgtatgct tctacagggg 12901 tttgagggaa acggatattg taattatcat ccttttgtct ttcactatat tcgttacttg 12961 ctaaataata atcaatattg gctttatata accaagtggt agcttttaaa gatagttttt 13021 catctttaat acataaatcg attatctctt ttgctttaac ataattttgg tcatagtaaa 13081 aattatatgc tcttgataat gagggttttt gtgcgtctac ggatagtagt acagttaata 13141 aaatcaaagt tatttttaat tgtttcatac ttattttaga ttaaaagaat aaccattaaa 13201 agattttacg tttatagaaa ttactcctca agattttcag tagtcgtatc gttattttcg 13261 gttacattat cttcttcttc gtcatcatca ggttcttctt taggtacaca ggttacggcg 13321 gcaatttggt catctgtatt caattcaatg agtttcactc cttgtgtagc tcttcccata 13381 atgcgaagcg tatcaacatg caaacgaatg gtcaatcctg agcgattaat aatcattaaa 13441 tcatcattat cggttacatt ttctatagca ataagacctc ctgttttttc ggtaatgcta 13501 atcgttttca ctccttttcc gcctcggttc gtgattcgat aatcatctaa taatgagcgt 13561 ttcccaaatc cattttcgga aacaacgagt atagtttggt caggattatc aatacaaatc 13621 atgccgacta caaagtcgtc gtcattagct aaggtaatcc ctttaacacc tgaggcattt 13681 cgtcccatgg ggcgtacatt tttctcatta aaacgtaccg cttttcctga gttcagagcc 13741 agcataattt cattttcccc gttagtaagt tttgcttcaa gaaggtggtc attttcgcga 13801 atagtaatag cgttaatacc gttcacgcgt gggcgggagt atgcttcgag cgaagttttt 13861 ttaattatac ctttttcggt gcaaagaatg atataattat tattgatata ttcgtcatcg 13921 gtaaggtcat gcacattgat gacggctttt attttgtcgt cactttcaat attcagcaag 13981 ttttggatag cacgaccttt cgaggtttta ctaccttccg ggatttcgta gacacgaagc 14041 cagaagcact ttcctttttc agtaaagaag agtaaatagt tgtgattcgt tgcgatgtaa 14101 aggtgttcga taaagtcttc atctcttgag gagccgcctc ttgagccttt cccgcctcga 14161 ttttgcactt tatattccga tgaagaggtg cgtttaatat atcctaagtg tgaaattgta 14221 ataacaactt ccgtatccgg aatcgtatct tcaattttga aatcggttgc tgaaaattct 14281 attcgagagc gtctttcgtc tccgtatttt tgtttaactt cgttaagttc atctttaata 14341 atctgcattc taaggctctc ttcggcaagc acacggttta gatattcgat taatttttgc 14401 agttcgtcat attcattttg taatttctcg cgttctaaac cggtcagttg tctaagtcgc 14461 atttcaataa ttgcacgagc ttgaatgtca gtgaattgcc atttttccat taagccgatg 14521 cgagcatctt cgggcgttgc cgatgcacgt attaaggcaa taatctcatc tataaaatcg 14581 agagctttca ggtagccttc taagatatgg gcacgttctt gagcttttcg caagtcatat 14641 tgagatctac gcactacaac atcgtggcga tgtttaacat attgtttgat gaggtctttt 14701 aaattcaatg tcatggggcg tccgttcact aacgcaacgt tattgatatt aaaagaggct 14761 tgtagggcag tatattggta caatttatta agaacgatat tcgggatagc ttcgcgttta 14821 agttcataga ctatttgcgt tccgtttcta cggtttgaca ggtcttcgat attgctaatt 14881 ccgtcaattt ttccttcttt aacaagttcc accgttcgtt ttatcatgtc ggacggatta 14941 acgaggtagg ggatagaggt aacgatgatt tgagtttttc cgtttacttc ttctattgta 15001 gcgtccccac gaagcacgac acgtccgcgt ccggtttcaa aagcttcttt cacgccgtcg 15061 tagccgtaaa ttgtacagcc tgtcgggaaa tccggtgctt ttatgtattg cattagctcc 15121 tcgaccgtaa tatcattatt atcaatataa gccgtaattc cgtcacaaca ctcggagaga 15181 ttatggggag ccatattggt tgccattcct actgcaattc ctgaagcgcc attgattaaa 15241 agattaggaa ttttaccggg caatacggta ggttcttcaa gagaatcatc gaaattagtg 15301 cggaaatcaa ccgtctcctt ctttatatct tcgagcatct cttcggcaat tttacgcatt 15361 cttgcttccg tataacgcat cgcagcaggg ctatcaccgt caatagaacc aaagttccct 15421 tgtccgtcaa caaaaggata acgtaaagac cagtcttgag ccatacgaac catcgaatcg 15481 tacactgccg tatctccgtg agggtgatat ttccctaaaa cttcaccgac tattctcgct 15541 gattttttat gaggttttga cgaagtgatg cccatatcgt acatggcata taagattctt 15601 cggtgtaccg gcttaaatcc gtctcgcgta tcggggagtg cccgagacat tatcactgac 15661 attgaatagt caatgtatgc ctttttcatt tgcgactcaa tatttaccga aataattttt 15721 tcttctccta tcatttttta taagtttttg taatagataa aacgctgttt tttaatagtt 15781 tacaattgac aaaagtaaga tacgaaaata caaaaaaaaa cgatgtagtt gtcttttttt 15841 tctacctttt tttcaccttt ttttgttaaa atctcaaacg gaaatccaat aatcgtccgc 15901 ataatccgac aaatagcctg tgggctttta gcagtttttc tcattttccc gtaatgttta 15961 tataaagtct taataatcag ctatatatat tatttctctg ttttttgtct attacaaaaa 16021 tgtgtaaaaa agaggagtat aagaataatt gtaattttct tttgggcgtg tcccgttcgc 16081 tgacgctcac gggtcggcgc ccggttccaa gtccgcgggc acaagccgtg gggacgcaag 16141 gcggcaaaaa gagcttacaa gctcgctttt ttgccgcc //