LOCUS       DS571191               80673 bp    DNA     linear   CON 17-APR-2008
DEFINITION  Entamoeba histolytica HM-1:IMSS scf_1104750519211 genomic scaffold,
            whole genome shotgun sequence.
ACCESSION   DS571191 AAFB02000000
VERSION     DS571191.1
DBLINK      BioProject: PRJNA142
            BioSample: SAMN02953605
KEYWORDS    WGS.
SOURCE      Entamoeba histolytica HM-1:IMSS
  ORGANISM  Entamoeba histolytica HM-1:IMSS
            Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida;
            Entamoebidae; Entamoeba.
REFERENCE   1  (bases 1 to 80673)
  AUTHORS   Loftus,B., Anderson,I., Davies,R., Alsmark,U.C., Samuelson,J.,
            Amedeo,P., Roncaglia,P., Berriman,M., Hirt,R.P., Mann,B.J.,
            Nozaki,T., Suh,B., Pop,M., Duchene,M., Ackers,J., Tannich,E.,
            Leippe,M., Hofer,M., Bruchhaus,I., Willhoeft,U., Bhattacharya,A.,
            Chillingworth,T., Churcher,C., Hance,Z., Harris,B., Harris,D.,
            Jagels,K., Moule,S., Mungall,K., Ormond,D., Squares,R.,
            Whitehead,S., Quail,M.A., Rabbinowitsch,E., Norbertczak,H.,
            Price,C., Wang,Z., Guillen,N., Gilchrist,C., Stroup,S.E.,
            Bhattacharya,S., Lohia,A., Foster,P.G., Sicheritz-Ponten,T.,
            Weber,C., Singh,U., Mukherjee,C., El-Sayed,N.M., Petri,W.A. Jr.,
            Clark,C.G., Embley,T.M., Barrell,B., Fraser,C.M. and Hall,N.
  TITLE     The genome of the protist parasite Entamoeba histolytica
  JOURNAL   Nature 433 (7028), 865-868 (2005)
   PUBMED   15729342
REFERENCE   2  (bases 1 to 80673)
  AUTHORS   Lorenzi,H., Amedeo,P., Inman,J., Schobel,S. and Caler,E.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-MAR-2007) The Institute for Genomic Research, 9712
            Medical Center Drive, Rockville, MD 20850, USA
COMMENT     This version of the project, JCVI-ESG2-1.0, represents 8x coverage
            of the genome.
FEATURES             Location/Qualifiers
     source          1..80673
                     /organism="Entamoeba histolytica HM-1:IMSS"
                     /mol_type="genomic DNA"
                     /strain="HM-1:IMSS"
                     /db_xref="taxon:294381"
     repeat_region   317..518
                     /rpt_family="LINE1"
     gene            1154..1863
                     /locus_tag="EHI_194040"
                     /old_locus_tag="46.t00052"
                     /db_xref="Pathema:EHI_194040"
     mRNA            1154..1863
                     /locus_tag="EHI_194040"
                     /old_locus_tag="46.t00052"
                     /product="snoRNP protein gar1, putative"
                     /note="transcript EHI_194040A"
                     /db_xref="Pathema:EHI_194040"
     CDS             1168..1713
                     /locus_tag="EHI_194040"
                     /old_locus_tag="46.t00052"
                     /note="encoded by transcript EHI_194040A;
                     GO_component: GO:0005732 - small nucleolar
                     ribonucleoprotein complex;
                     GO_function: GO:0019843 - rRNA binding;
                     GO_process: GO:0006364 - rRNA processing"
                     /codon_start=1
                     /product="snoRNP protein gar1, putative"
                     /protein_id="EAL49334.2"
                     /db_xref="Pathema:EHI_194040"
                     /translation="MSFRGGRGGNRGRGRASFGGRDQQPSGELVPYGKFLHAAETVMV
                     FKATSTTQYPAFNAIVYNEKKAEVGKVGEVFGPLNDYYFSVVPVEGVKPDSYNVDDQI
                     YLYTDKLFSVDRLKNPPAPVKRGGAKGGAKGGANNRGSRGGNRGGSRGGFNNRGARGG
                     NKGSFGGNRGGFGGNKGPRNH"
     repeat_region   complement(2081..2632)
                     /rpt_family="LINE1"
     gene            complement(<3191..>4006)
                     /locus_tag="EHI_194050"
                     /old_locus_tag="46.t00051"
                     /db_xref="Pathema:EHI_194050"
     mRNA            complement(<3191..>4006)
                     /locus_tag="EHI_194050"
                     /old_locus_tag="46.t00051"
                     /product="hypothetical protein"
                     /note="transcript EHI_194050A"
                     /db_xref="Pathema:EHI_194050"
     CDS             complement(3191..4006)
                     /locus_tag="EHI_194050"
                     /old_locus_tag="46.t00051"
                     /note="encoded by transcript EHI_194050A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49333.1"
                     /db_xref="Pathema:EHI_194050"
                     /translation="MDVMCSKEVKQHKKKSGEDQTISDDVRHKQKHEENVFGQWGFLI
                     YYILLKGGSVTIKPFVKKTDIDKRNQIDFCSVEVNGKILSAEEIQKQVIPMIDKSINH
                     KYFRRTLRKYIHDNIMNEVVEWCKEEAKKEKIYILTKSSKKAKNENKPPNTIINSVNI
                     NGKNYNRRFITTNCGNWLKEVLKCLIPNPPPKTHTIIISQKTVPPNIIMNGMGLENLI
                     TKTPTITQINGYAGYYDACGELRLWNCQLYLPFPIEDKLNPIDPKSSDSQTNL"
     gene            complement(<5822..>6511)
                     /locus_tag="EHI_194060"
                     /old_locus_tag="46.t00050"
                     /db_xref="Pathema:EHI_194060"
     mRNA            complement(<5822..>6511)
                     /locus_tag="EHI_194060"
                     /old_locus_tag="46.t00050"
                     /product="CAAX amino terminal protease family"
                     /note="transcript EHI_194060A"
                     /db_xref="Pathema:EHI_194060"
     CDS             complement(5822..6511)
                     /locus_tag="EHI_194060"
                     /old_locus_tag="46.t00050"
                     /note="encoded by transcript EHI_194060A"
                     /codon_start=1
                     /product="CAAX amino terminal protease family"
                     /protein_id="EAL49332.2"
                     /db_xref="Pathema:EHI_194060"
                     /translation="MKGFGLQVYFFQTVICSLVVINFMYYRYSMSGNVITLNTFIQEI
                     FTLKGKWISTLIKAGMGFLSIFCLRVILYYCHIDTSNLFSNFYTDGELDIPVVLDNLF
                     FSVITEEIALRRSMLNTIKTYTPTSKNYLFIISGIWFGLIHFVNIGTSSFTVTYVLFQ
                     MSYGMVIGYTFGIFTEYLGIFPSIILHSMNNACAIFIPFVFSPFLLLYSILSALLLIY
                     LSHKLLISLSL"
     gene            complement(<6546..>7289)
                     /locus_tag="EHI_194070"
                     /db_xref="Pathema:EHI_194070"
     mRNA            complement(<6546..>7289)
                     /locus_tag="EHI_194070"
                     /product="26S protease regulatory subunit S10B, putative"
                     /note="transcript EHI_194070A"
                     /db_xref="Pathema:EHI_194070"
     CDS             complement(6546..7289)
                     /locus_tag="EHI_194070"
                     /note="encoded by transcript EHI_194070A;
                     GO_function: GO:0008568 - microtubule-severing ATPase
                     activity"
                     /codon_start=1
                     /product="26S protease regulatory subunit S10B, putative"
                     /protein_id="EDS89592.1"
                     /db_xref="Pathema:EHI_194070"
                     /translation="MEIEGERKSVLKAYLQKLKTYQAKEEALEKIKETLKVSKENMGR
                     NEEMLLSLQTIGMSIGEVLKCLSEEKYIVKVSLGPHYVVGCRSCIDKKKITQGTRVAL
                     DVSTNTIMKILPREVHPAVYSMTVESPGKVKYEDIGGLRNQMREIREVIELPMTNPEL
                     FERVGVKAPKGVLLYGPPGTGKTLLARALASNLECHFLKVVASGIVDKYLGEXXXXXX
                     XXXXXXXXXXXXXXXXXXXXXXXXXXXXA"
     gap             6554..6653
                     /estimated_length=100
     repeat_region   complement(8309..9253)
                     /rpt_family="LINE1"
     repeat_region   complement(9215..9406)
                     /rpt_family="LINE1"
     repeat_region   9402..9502
                     /rpt_family="SINE2"
     repeat_region   complement(9482..9947)
                     /rpt_family="LINE1"
     repeat_region   10054..10195
                     /rpt_family="LINE1"
     repeat_region   10183..10381
                     /rpt_family="LINE1"
     gene            <10818..>11870
                     /locus_tag="EHI_194180"
                     /old_locus_tag="46.t00046"
                     /db_xref="Pathema:EHI_194180"
     mRNA            <10818..>11870
                     /locus_tag="EHI_194180"
                     /old_locus_tag="46.t00046"
                     /product="hypothetical protein"
                     /note="transcript EHI_194180A"
                     /db_xref="Pathema:EHI_194180"
     CDS             10818..11870
                     /locus_tag="EHI_194180"
                     /old_locus_tag="46.t00046"
                     /note="encoded by transcript EHI_194180A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49328.1"
                     /db_xref="Pathema:EHI_194180"
                     /translation="MEVKGKETKPIQNTGNETKELPKITNSLENVQKGIKQTQEKNVS
                     FEDETKEEEISKEYTFENEEYNEETEKKEGDDLLFTENSIINAASIQDKINTKEEKAE
                     KKKNPNNKLKNEWKKLKKSLDSHQKKIIDAYIDYKVEKKVNKIIQQLQKDETFNQFEM
                     SKKNFKVNEEKIKYYIKQQQKDMKHFIQKQILYQRMMYQYPYYYYPYCYYPQPYNING
                     DSPYFFNQFNSIEQPLSYNHQYCYGKTCSCLTQKNQQHTPTHQVSSAPIQNEVEQTLH
                     QSSHHASSQSINLDRKLESQTKQEIENLFPHSPTPPFQVPQFQQPNLVCPCYPQADNQ
                     RLCSNFGQPQYSQPFQ"
     gene            complement(<12063..>12659)
                     /locus_tag="EHI_194190"
                     /old_locus_tag="46.t00045"
                     /db_xref="Pathema:EHI_194190"
     mRNA            complement(<12063..>12659)
                     /locus_tag="EHI_194190"
                     /old_locus_tag="46.t00045"
                     /product="hypothetical protein"
                     /note="transcript EHI_194190A"
                     /db_xref="Pathema:EHI_194190"
     CDS             complement(12063..12659)
                     /locus_tag="EHI_194190"
                     /old_locus_tag="46.t00045"
                     /note="encoded by transcript EHI_194190A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49327.1"
                     /db_xref="Pathema:EHI_194190"
                     /translation="MKSKKPITTPKHLSDNPLNKKPFETIPYRFSESGNIREPLYSMS
                     KDFHGYSMSFPGRKNSGGLSDDDYDESDSDCHNETDEEHPDLSSDDERTTEDNDETEV
                     IITEENYEEIVDRLKQMVLNQIISQHQNEQTKLRKRFIECCSIINKEKDDIIHDMELF
                     GLGSLDKDKINDTLSCLENTINDLQRNFEDKKYISTIN"
     gene            <12884..>14497
                     /locus_tag="EHI_194200"
                     /old_locus_tag="46.t00044"
                     /db_xref="Pathema:EHI_194200"
     mRNA            <12884..>14497
                     /locus_tag="EHI_194200"
                     /old_locus_tag="46.t00044"
                     /product="amino acid transporter, putative"
                     /note="transcript EHI_194200A"
                     /db_xref="Pathema:EHI_194200"
     CDS             12884..14497
                     /locus_tag="EHI_194200"
                     /old_locus_tag="46.t00044"
                     /note="encoded by transcript EHI_194200A;
                     Similarity to PF01490: Transmembrane amino acid
                     transporter protein"
                     /codon_start=1
                     /product="amino acid transporter, putative"
                     /protein_id="EAL49326.1"
                     /db_xref="Pathema:EHI_194200"
                     /translation="MSSSFPNEPSTDHQETAVLVDENEKVDNSETLPPLNSDSSDIEE
                     NLKEIEEEQEIVSKSVNVHTISPLQTFGILINYIVGTGVFGLPYAFENAGLGLSLITT
                     LFFYLMSIVTAIWVLENMARSSGVMETYRRSRNAQRPQNEIEYEVYNYTRMSAIFFGK
                     GGKMTSIIILSFFCYGALWAYSSVFSSSVTMILWKYPLSKFGECSIVMGDWDLFGPCH
                     LTYLSGIVLFALIVIPLSLMGVAEQAILQNILTCWRFFCFGVMALTCIIHIIYNSVKG
                     TYEVIPPSKSTLTFFIDIGGFGTLFSSCSVALACHQNLPDVVTPTKPKNHLRRIVVLG
                     ITTATILYVIIGFACSFCFGDATRTPVTHNWLGFTGCNGGFGVCDDGSSAKWYGVVVQ
                     WVILLFPAINLTSEYPLVCVTLSSNLLQMIPKQWKEKSPKIWLYSSRLVAAVPPLIAG
                     AIKGDLEVIFNFAGIFGFFLLFIIPGVLQIYSKFIIRRKWGSKTYVTSFSGKYSSSYW
                     AWPILIIAIICFSFALVQFVADVIGLSWF"
     gene            <14623..>15927
                     /locus_tag="EHI_194210"
                     /old_locus_tag="46.t00043"
                     /db_xref="Pathema:EHI_194210"
     mRNA            <14623..>15927
                     /locus_tag="EHI_194210"
                     /old_locus_tag="46.t00043"
                     /product="hypothetical protein"
                     /note="transcript EHI_194210A"
                     /db_xref="Pathema:EHI_194210"
     CDS             14623..15927
                     /locus_tag="EHI_194210"
                     /old_locus_tag="46.t00043"
                     /note="encoded by transcript EHI_194210A;
                     GO_process: GO:0006464 - protein modification process;
                     GO_process: GO:0006512 - ubiquitin cycle;
                     GO_process: GO:0015031 - protein transport"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49325.1"
                     /db_xref="Pathema:EHI_194210"
                     /translation="MQEINFFLSSVREFYNDCDSVTKDIKRLQIKYPKLKIGITLSKY
                     SSHQYISLEGFLPIVYERKVFGVPMLIAFTYNYPLSPPELSCFISQGMEIVKNHPLVK
                     EDGFIQNIQQQWNSSTDLLLLLERLLAFFGSIPPVRKNAQLSPFLYSKSNSFTPNPTT
                     SYQQYLTQQSNLLYSTNNPTYQQQMSSTTQYYPYQNQYPSYQNIHNPYLPYSHPQYTP
                     NQYPSLSNPLLSPQSSTFITPQQYQNEIRSSTKISNTNITDYYVQDYDHSKEKTLTNP
                     SELQQQNNTFTKYKQSEQEQTTLNENYNFVSPYNQYYINKEGVQNNLMKKDQIQQMKD
                     SIIYSINQTKEEIESLQQWISNNPLPKDVSLIDDFKKQINKEQMEKFTIQSKIKAMND
                     LLETLGEVVGNETVPIDKSLLIIRGIAENKFELKKQLMQLNY"
     gene            complement(<16017..>17218)
                     /locus_tag="EHI_194220"
                     /old_locus_tag="46.t00042"
                     /db_xref="Pathema:EHI_194220"
     mRNA            complement(join(<16017..16233,16287..16897,16988..>17218))
                     /locus_tag="EHI_194220"
                     /old_locus_tag="46.t00042"
                     /product="protein phosphatase domain-containing protein"
                     /note="transcript EHI_194220A"
                     /db_xref="Pathema:EHI_194220"
     CDS             complement(join(16017..16233,16287..16897,16988..17218))
                     /locus_tag="EHI_194220"
                     /old_locus_tag="46.t00042"
                     /note="encoded by transcript EHI_194220A;
                     GO_function: GO:0004721 - phosphoprotein phosphatase
                     activity"
                     /codon_start=1
                     /product="protein phosphatase domain-containing protein"
                     /protein_id="EAL49324.1"
                     /db_xref="Pathema:EHI_194220"
                     /translation="MFSDFLSTPLDSSSPRMAYSASPRSRKPAIYRGTPPTFTSTLRC
                     VQSGTEIGLPEETWEVNIEPDGTIKKEGKTLNSELIEPLPRFAIGIAQTRGVRENMED
                     VISTCHLERNKDLVGVFDGHNGDSAARIAATLLKQDTKNYTLLDDIHFIDLFNHLQKK
                     IVSQTQSGTTATVLYLGCEIVKIAYVGDCSVYLIDNNGINKITVPHRCGNILEEKRIL
                     TSGGTIEDIDGIRRVNGIINITRSLGDKELHPPLSFEPEIYSVNVKKGLSHIVIISDG
                     ADTVNEKELEKMIRRSPTVSIAAAAIRNEAFKQKSKDNISVVVVDMKFSSYERKTTSP
                     LVDDLCIAGGDEDNPFDF"
     gene            <17391..>18205
                     /locus_tag="EHI_194230"
                     /db_xref="Pathema:EHI_194230"
     mRNA            join(<17391..17534,17600..>18205)
                     /locus_tag="EHI_194230"
                     /product="hypothetical protein"
                     /note="transcript EHI_194230A"
                     /db_xref="Pathema:EHI_194230"
     CDS             join(17391..17534,17600..18205)
                     /locus_tag="EHI_194230"
                     /note="encoded by transcript EHI_194230A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EDS89593.1"
                     /db_xref="Pathema:EHI_194230"
                     /translation="MKRRTTDANDEKHIEAKDVSKILDVLSNSIERKGYWHRIVRKLK
                     ECLTKLITDETQQQYLEIVEKLITNEPNENICDVINDKISLIEAMQSYHISFLQSQIV
                     TKCSQILKFKQILSQDAFEFGKGVTSAIENIKLISASLKKAYLTNETGEFDKTTILSQ
                     EVVSMLTLTFKILINELKNKPIKRIWGKISTKPFVKVCEENPQLWNDEQKELLLELSE
                     IISNEYSEKQKATSYDEALTKWSQAEIRMNK"
     gene            18366..>18852
                     /locus_tag="EHI_194240"
                     /old_locus_tag="46.t00041"
                     /db_xref="Pathema:EHI_194240"
     mRNA            18366..>18852
                     /locus_tag="EHI_194240"
                     /old_locus_tag="46.t00041"
                     /product="hypothetical protein"
                     /note="transcript EHI_194240A"
                     /db_xref="Pathema:EHI_194240"
     CDS             18367..18852
                     /locus_tag="EHI_194240"
                     /old_locus_tag="46.t00041"
                     /note="encoded by transcript EHI_194240A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49323.1"
                     /db_xref="Pathema:EHI_194240"
                     /translation="MKFDATKFFGNLAGEIQQDIIEILNLKYEIPKDANVLIERITKN
                     IFSHYLSYTVIGIIFASVMSLFELENFACLFFFVGTLVSYLIIEDVDQSILEKAKIEP
                     VYVYGIAVAIYLLLALLVDIAGFSFFVLIIVSLSIIGLASVQTKVNKNEPTRETLTVS
                     K"
     gene            <18952..>19305
                     /locus_tag="EHI_194250"
                     /old_locus_tag="46.t00040"
                     /db_xref="Pathema:EHI_194250"
     mRNA            <18952..>19305
                     /locus_tag="EHI_194250"
                     /old_locus_tag="46.t00040"
                     /product="hypothetical protein, conserved"
                     /note="transcript EHI_194250A"
                     /db_xref="Pathema:EHI_194250"
     CDS             18952..19305
                     /locus_tag="EHI_194250"
                     /old_locus_tag="46.t00040"
                     /note="encoded by transcript EHI_194250A;
                     GO_function: GO:0004045 - aminoacyl-tRNA hydrolase
                     activity"
                     /codon_start=1
                     /product="hypothetical protein, conserved"
                     /protein_id="EAL49322.1"
                     /db_xref="Pathema:EHI_194250"
                     /translation="MEYKMVLCVRNDIPMSIGKKCSQCAHAAIGCFQKAMEISPECII
                     EWENQGAKKVVVKIEDVKEFEVMKQTYEELGILYYEVVDAGRTEINPGTITVLGVGPG
                     PTVLIDVVTGDKHLL"
     gene            <19455..>20546
                     /locus_tag="EHI_194260"
                     /old_locus_tag="46.t00039"
                     /db_xref="Pathema:EHI_194260"
     mRNA            join(<19455..19736,19782..>20546)
                     /locus_tag="EHI_194260"
                     /old_locus_tag="46.t00039"
                     /product="protein phosphatase domain-containing protein"
                     /note="transcript EHI_194260A"
                     /db_xref="Pathema:EHI_194260"
     CDS             join(19455..19736,19782..20546)
                     /locus_tag="EHI_194260"
                     /old_locus_tag="46.t00039"
                     /note="encoded by transcript EHI_194260A;
                     GO_function: GO:0004721 - phosphoprotein phosphatase
                     activity"
                     /codon_start=1
                     /product="protein phosphatase domain-containing protein"
                     /protein_id="EAL49321.2"
                     /db_xref="Pathema:EHI_194260"
                     /translation="MSLLIRYSTSSNASPIQEQQKAKLHKRIRSTDSLTKCAFYGQER
                     PVFVNGKIIKSSGVSLPKLSNSYLLKRGGSPLKTENGNVLDQSEEDVLLFKQQYSCSK
                     RFDIGTAQTIGKRVYMEDTLMVKGELYDDIDFIGVFDGHNGQGAAIKSMHTFYSLIDG
                     YTVHSDHVKDHLSKVFEQMHTLVSMSTESGTTASILLIRENDVIICRCGDSPIYVLTT
                     DDEIMKVGKDHNLYDKDEVEMIKQNGGNIVNVSGVLRVNGKITITRSIGDKQFHPPLS
                     CLPSIDIISLSTIKSILVASDGISVVSEDFLREILLEEFTSDIKAQCVRNNALEKDSK
                     DNISVVVVQIRTII"
     gene            complement(20825..>22150)
                     /locus_tag="EHI_194270"
                     /old_locus_tag="46.t00038"
                     /db_xref="Pathema:EHI_194270"
     mRNA            complement(20825..>22150)
                     /locus_tag="EHI_194270"
                     /old_locus_tag="46.t00038"
                     /product="60S ribosomal protein L4, putative"
                     /note="transcript EHI_194270A"
                     /db_xref="Pathema:EHI_194270"
     CDS             complement(20855..22150)
                     /locus_tag="EHI_194270"
                     /old_locus_tag="46.t00038"
                     /note="encoded by transcript EHI_194270A;
                     GO_component: GO:0005622 - intracellular;
                     GO_component: GO:0005840 - ribosome;
                     GO_function: GO:0003735 - structural constituent of
                     ribosome;
                     GO_process: GO:0006412 - translation"
                     /codon_start=1
                     /product="60S ribosomal protein L4, putative"
                     /protein_id="EAL49320.1"
                     /db_xref="Pathema:EHI_194270"
                     /translation="MSSRPFVTIYDGITGEAEKTQVRLPAVFLAPIRGDVVHFVYRNQ
                     SKNTRQPEGVSTKAGKQHSAISWGTGRAVARIPRISGSGSGRNGQGAFGNMTRKGHMF
                     SPLKNFRKWQRKTPKQMRRFAVASCIAASAVPALVSARGHHIAGVPQIPLVVNSKSIS
                     VIKKTKQAVYLLKKINAYSDVLKVIASKTVRAGQGKMRGRKIKERKGPLVVYGNDDLQ
                     AVKAFRNIPGVDTCRVENLSVLNLAPGCHIGRFIIWTESAFKKLNTIFGTQKKMAQGK
                     SGFRIAHAQMAVPDMKRVVVAAEKAKLLRAKIVLPKVPKRANPLKNWAAMVKLNPYAK
                     IASHKLAQVAKAQAAHKAQYAAKMEKILAAKKEALNQSVAKRFGKTQKVDGKVVKVKV
                     ENNLLKATVKRTAKQDAYMKKYDGIVKANAKKYAEKIGF"
     gene            <22442..>23133
                     /locus_tag="EHI_194280"
                     /old_locus_tag="46.t00037"
                     /db_xref="Pathema:EHI_194280"
     mRNA            join(<22442..22634,22693..22793,22843..>23133)
                     /locus_tag="EHI_194280"
                     /old_locus_tag="46.t00037"
                     /product="Rab family GTPase"
                     /note="transcript EHI_194280A"
                     /db_xref="Pathema:EHI_194280"
     CDS             join(22442..22634,22693..22793,22843..23133)
                     /locus_tag="EHI_194280"
                     /old_locus_tag="46.t00037"
                     /note="encoded by transcript EHI_194280A;
                     GO_component: GO:0005622 - intracellular;
                     GO_function: GO:0005525 - GTP binding;
                     GO_process: GO:0007264 - small GTPase mediated signal
                     transduction"
                     /codon_start=1
                     /product="Rab family GTPase"
                     /protein_id="EAL49319.1"
                     /db_xref="Pathema:EHI_194280"
                     /translation="MSNAADYTFKVLIIGEPSVGKTAIMERYCEDKFHDELISTIGVD
                     FNSKLVKVGDLTIKLQLWDTAGQERFRNVTSSYYKGTQGCLVVYDVSDVESFNKITHW
                     IQEYQIEQEIAFIIIVGNKIDLPSKVTNEQADAAAKEQGYQHMRCSAKTGEGVNEIFE
                     TLAKGIYNNKEIMANIPKKNNITIVSPEKQSGCC"
     gene            complement(<23249..>24433)
                     /locus_tag="EHI_194290"
                     /old_locus_tag="46.t00036"
                     /db_xref="Pathema:EHI_194290"
     mRNA            complement(<23249..>24433)
                     /locus_tag="EHI_194290"
                     /old_locus_tag="46.t00036"
                     /product="leucine rich repeat protein, BspA family"
                     /note="transcript EHI_194290A"
                     /db_xref="Pathema:EHI_194290"
     CDS             complement(23249..24433)
                     /locus_tag="EHI_194290"
                     /old_locus_tag="46.t00036"
                     /note="encoded by transcript EHI_194290A;
                     Pubmed:16199101 This functional annotation is a direct
                     result of community participation in an Entamoeba
                     Annotation Jamboree;
                     GO_function: GO:0003674 - molecular_function;
                     GO_process: GO:0008150 - biological_process"
                     /codon_start=1
                     /product="leucine rich repeat protein, BspA family"
                     /protein_id="EAL49318.1"
                     /db_xref="Pathema:EHI_194290"
                     /translation="MNKKIIGHYEIMIVSMYFNDINDFINLELAVKRFKGNMERFHFN
                     PISLTTKTLKYFPSLETLHLYNRNDKELHNKQIIKYIIWYKVSYTYYMKHKSNTLKEF
                     KNITFNEDDVTNFGYEIPKQIKIVKKNCFINNHSFKEITIPPSVLSIHRSCLWVCKQL
                     RSLKISQQDYVIFSNHLFFNFYNLCSLELPNSIVKINNKKIPSIQNNQIFNIPTTVTS
                     LNDYCFSECSSLLSIQIPSSVILIGNCAFKKCYFLQVIQLPIDILTLPKSCFALCTSL
                     QTIILPNSLKCLRNKCFVNCYSLHSITIPNSVSQIGSHCFEGCRSLSSVILSTSLSSI
                     SSNCFNFCSSLRSITLHSSILSIETYSFKNCYSLTTVQINSPLCSIDPTSFEGCINLH
                     EI"
     gene            <24772..>25389
                     /locus_tag="EHI_194300"
                     /old_locus_tag="46.t00035"
                     /db_xref="Pathema:EHI_194300"
     mRNA            <24772..>25389
                     /locus_tag="EHI_194300"
                     /old_locus_tag="46.t00035"
                     /product="hypothetical protein"
                     /note="transcript EHI_194300A"
                     /db_xref="Pathema:EHI_194300"
     CDS             24772..25389
                     /locus_tag="EHI_194300"
                     /old_locus_tag="46.t00035"
                     /note="encoded by transcript EHI_194300A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49317.1"
                     /db_xref="Pathema:EHI_194300"
                     /translation="MHRTTREHHLIDRYQNDIPQKSKTLRLDGEGIILGTSKKISTNI
                     NELSTDKLVQIHRLFYGTMGVATERLMNVLAFCGLEQTIKSEFNKNSKRVQSALEKKS
                     DEVIDELIRIFCLHQSNKRIDKLEEIFNFIVCPSRPNCDEQIDFRDEALDEIVEEQDQ
                     SFLSSFGDLDASTDDGEIYIEDEDLDLKKPKTRNTRKSTKKTTKK"
     gene            <25589..>27115
                     /locus_tag="EHI_194310"
                     /old_locus_tag="46.t00034"
                     /db_xref="Pathema:EHI_194310"
     mRNA            <25589..>27115
                     /locus_tag="EHI_194310"
                     /old_locus_tag="46.t00034"
                     /product="amino acid transporter, putative"
                     /note="transcript EHI_194310A"
                     /db_xref="Pathema:EHI_194310"
     CDS             25589..27115
                     /locus_tag="EHI_194310"
                     /old_locus_tag="46.t00034"
                     /note="encoded by transcript EHI_194310A;
                     Similarity to PF01490: Transmembrane amino acid
                     transporter protein"
                     /codon_start=1
                     /product="amino acid transporter, putative"
                     /protein_id="EAL49316.1"
                     /db_xref="Pathema:EHI_194310"
                     /translation="MSEEEEKNIICDDTSVSNYDSKPLKKEQELLLNEKEKKETHSYS
                     QAAGFATVINYIIGTGVFGIPFAYFTGGLPLSAIILIGFFIINVTTMNYLIDSMARSE
                     GRKEIKENGGENEFNTVPVNELKFRLFDYTTLGEMWGGQFLRWFNFACLVLYLYGSLW
                     AYAATSVSTLTTLFWMIYGDTERCIERKGNWECQLAYYISLAIYSIIVISLSFIDLSK
                     QGKLQMALTFYRFFAFSVMLITCIVQLIVSGPIDSDISFLYTFKWVGFGTAFTHTAFA
                     LTCHQNLPDAITPVNKKKYLFYTTAGAMFLSAAFYFLIGFICSWTFGSDVLSPITNAW
                     SKYTGLAGGWGKGETQWYAYPIQYIILLFPVVNLCNSYPLLGTTLSTNIQTCFTYSFR
                     EKHNKITQYSSLAIAYLPPLLLTCAIGSLQVIFDVTGLLAIFLAFTIPATLEILSIYK
                     NKKDFGKGSIKTPYTFKVLANYILTGIVVVVSFILLGLSLYFLIAQLLTQEEQESSSN
                     "
     gene            <27206..>28261
                     /locus_tag="EHI_194320"
                     /old_locus_tag="46.t00054"
                     /db_xref="Pathema:EHI_194320"
     mRNA            <27206..>28261
                     /locus_tag="EHI_194320"
                     /old_locus_tag="46.t00054"
                     /product="hypothetical protein"
                     /note="transcript EHI_194320A"
                     /db_xref="Pathema:EHI_194320"
     CDS             27206..28261
                     /locus_tag="EHI_194320"
                     /old_locus_tag="46.t00054"
                     /note="encoded by transcript EHI_194320A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49336.1"
                     /db_xref="Pathema:EHI_194320"
                     /translation="MSDIPRRVTRSKTKKMEEDGTEEEDDDFLDDQEEYHSDEDLLDE
                     EDISVEEDGTEEDEKEERKKKRPRSTRTPKSRGRKDKGKPLTFKQMKELYITRENALS
                     YADTAIFERYIVNKYVKVVNGQEEYISLVKSVDISSNIKQVDRRKVAWDLTIETTAFD
                     GSRIVGIGELSNSTLGIENYKRYIEDGKETDIGVMTTKQAREEIKKIETIDNYIPSEE
                     ETDKYNEYRKKVYGLKDEEETVQFGKENKVGLEEEREVQNENDKKMEEEVPCDFMINQ
                     EIYKSLEECNKRCTEMENYLIFKKEEQNQVKELCEKFFFNYQIPKQTTIYQQTVVIAK
                     ETDGKDKLSEEPLAKYL"
     gene            <30825..>31631
                     /locus_tag="EHI_194330"
                     /old_locus_tag="46.t00033"
                     /db_xref="Pathema:EHI_194330"
     mRNA            <30825..>31631
                     /locus_tag="EHI_194330"
                     /old_locus_tag="46.t00033"
                     /product="autophagocytosis protein, putative"
                     /note="transcript EHI_194330A"
                     /db_xref="Pathema:EHI_194330"
     CDS             30825..31631
                     /locus_tag="EHI_194330"
                     /old_locus_tag="46.t00033"
                     /note="encoded by transcript EHI_194330A"
                     /codon_start=1
                     /product="autophagocytosis protein, putative"
                     /protein_id="EAL49315.1"
                     /db_xref="Pathema:EHI_194330"
                     /translation="MSVLSTLKRKAYETYTKSVDLVKPTLTESQFIEKGVLTPEEFVN
                     AGDFLVNKYRTWQWVGASDCKKTVDYLPADKQFLITRNIRCATRAQGGPPTKTETLIV
                     DGEEFEVPLEEKPEEVFEEDSDDIVDADDIVDADELSEEADDTVATVDVGKTRTYDIS
                     IIYSHFDRTPKVWLLGYDEDHKPLTESQMFEDLSATHAGQTATTDTHPFLDIKEIYIH
                     PCRHAQVMKKRVDEMIADGKTPRVDLYLMIFLKFLATVIPTMEYDYGKDF"
     gene            <31778..>32974
                     /locus_tag="EHI_194340"
                     /old_locus_tag="46.t00032"
                     /db_xref="Pathema:EHI_194340"
     mRNA            <31778..>32974
                     /locus_tag="EHI_194340"
                     /old_locus_tag="46.t00032"
                     /product="hypothetical protein, conserved"
                     /note="transcript EHI_194340A"
                     /db_xref="Pathema:EHI_194340"
     CDS             31778..32974
                     /locus_tag="EHI_194340"
                     /old_locus_tag="46.t00032"
                     /note="encoded by transcript EHI_194340A;
                     Possible member of the Drug/Metabolite Transporter (DMT)
                     Superfamily
                     Ref:http://www.tcdb.org/tcdb/tcfamilybrowse.php?tcname=2.A
                     .7 This functional annotation is a direct result of
                     community participation in an Entamoeba Annotation
                     Jamboree."
                     /codon_start=1
                     /product="hypothetical protein, conserved"
                     /protein_id="EAL49314.1"
                     /db_xref="Pathema:EHI_194340"
                     /translation="MADEQNEALGYVCVIVAVLCFGSNFTVVKKFPTGDGFFFQWVMS
                     IGILIVGIFSLLFYNVINKGTIYFEPFAMLGGLIWCTGNLLCVPVIQLIGLSLGPGIW
                     GVGNMVMGWLTGTFGWFGLNADKDNVNIFWLNCVGAVLAACSVPCYALIKTSTKAERE
                     ALKKAEAEAKDNEIELSNSKENKVEISKNSSSSSRSSDEIQHPEEDIKELNDKAFEQG
                     SEEENTTILVSEEESPIFKLLKAMPKWLQMIVGLILAIASGILFGSAFDPAKYLQDNG
                     LASPEGINYVLAHFLGIFLSSTFYFICYIITFRNKPFIYRETILPGMVSGIMWAIAQV
                     CWFVANTNLPYVVSYPLICAGPGLLSALWGIIVFGEIRGWKNFLFFAIGTLILIGGIV
                     CIVVSK"
     gene            complement(<33906..>35778)
                     /locus_tag="EHI_194350"
                     /old_locus_tag="46.t00031"
                     /db_xref="Pathema:EHI_194350"
     mRNA            complement(join(<33906..34142,34198..>35778))
                     /locus_tag="EHI_194350"
                     /old_locus_tag="46.t00031"
                     /product="hypothetical protein"
                     /note="transcript EHI_194350A"
                     /db_xref="Pathema:EHI_194350"
     CDS             complement(join(33906..34142,34198..35778))
                     /locus_tag="EHI_194350"
                     /old_locus_tag="46.t00031"
                     /note="encoded by transcript EHI_194350A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49313.1"
                     /db_xref="Pathema:EHI_194350"
                     /translation="MTTNITEIIPLSESNQLIIYSNKRASVINISTTEITCNVDLSEN
                     TVLTSFHKTSQYQGNLCVVSMSGTEFYTCKEGVLEYIGTVPQGTECNGQVFTFTDCSM
                     QENQVVFSTTDGSILFFEYSTLDQQAIIPLIQNSIETIEYTQNNGMLYVIDTNGTFFS
                     LEINKTSLTIKRCYAKEDLHSFIPIFDSKKVQLIPTPNGCLLLINGNVLEYIKDIPSL
                     YLYTISDAQHACSINGKTYVCTLNGLYVFTQCDNESIQSFKLTSPTPAIKTLIQPPQV
                     VIFTLDSVHLTQLPVVHSRQTINAHKQLPINYKLSRMSHEYTLVNLVFGSGKSLYGID
                     SNGNIFYSSNINQQETTLFGKINVYQPGYALSYILPNKLYGVFGMGESLEVAHLETHQ
                     HVTTAYLSSDKKPDECITCIDGNKIDQSLFAVGFYNGMVATINTEKVLFKTLYSHSHR
                     VVTIKYINNIIASLDEDGNFIMEDNQGKIANNPISFDVFGMMLLVVENNSVQLISLND
                     LSVVASWEISSNIIDAKFSCDGMHVVVVSKERIVILKSSDLGVLNYISVNSMLSTLKL
                     NAEVHCMTISKEVPCQFAISLTGGYYVLIEPKNYKEWKY"
     gene            <36204..>37088
                     /locus_tag="EHI_194360"
                     /db_xref="Pathema:EHI_194360"
     mRNA            <36204..>37088
                     /locus_tag="EHI_194360"
                     /product="hypothetical protein"
                     /note="transcript EHI_194360A"
                     /db_xref="Pathema:EHI_194360"
     CDS             36204..37088
                     /locus_tag="EHI_194360"
                     /note="encoded by transcript EHI_194360A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EDS89594.1"
                     /db_xref="Pathema:EHI_194360"
                     /translation="MSESKSSTSSSSSPFSSVSSSSVSSSQILDNKEIDEQMSESESS
                     SSSNESTVKNTTKVKPLSDSSLNIKSKPHPMSESETSSSGSSSKSSSESSSSTHPSIK
                     EVEKPTMEIESKLSDQPVIKTTLNKSQESNSQELLSQSVPSTNKQTATELSENDSSSD
                     NKVTKEMSEDLSIDLEKDDEVSTGDDKSSEEDNITSEEEDKSSEEEDKSSEEEDGSYS
                     IDEEERIANQNKKYLTQLLKEFGDDVNELRMKATSFKAVNIEEITSALSQGINMFSDL
                     ELELLGKECVIPSSLNQS"
     gene            <37173..>38087
                     /locus_tag="EHI_194370"
                     /old_locus_tag="46.t00055"
                     /db_xref="Pathema:EHI_194370"
     mRNA            join(<37173..37595,37650..>38087)
                     /locus_tag="EHI_194370"
                     /old_locus_tag="46.t00055"
                     /product="hypothetical protein"
                     /note="transcript EHI_194370A"
                     /db_xref="Pathema:EHI_194370"
     CDS             join(37173..37595,37650..38087)
                     /locus_tag="EHI_194370"
                     /old_locus_tag="46.t00055"
                     /note="encoded by transcript EHI_194370A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49337.2"
                     /db_xref="Pathema:EHI_194370"
                     /translation="MNDTTSTKDEHIMSPSKIAIKQNFSQMDYHYGCSCYIAKLEESK
                     EQQRLYFKPEKEYGIGSHSLCSIRLTPNAEPLIALFQVNLRGDVSIIPRTKKTSIKIN
                     GNNITTATKLNNFDELDIGDLHFQYIVFYENIKYQNKREFNEVGNHNDIIRNTLTKFF
                     IKENYKGSDISPFVNVVHASTKIDEALLLCLNKLKELTPNPGNDKFIGLLRQMTSQLF
                     CISSTSIGFNVSYYESDVYNFTNKVKKTPSRKINFDEMQDSEDPFEAFKKANENKQEK
                     TLKKPQITDN"
     gene            <38838..>39413
                     /locus_tag="EHI_194380"
                     /old_locus_tag="46.t00028"
                     /db_xref="Pathema:EHI_194380"
     mRNA            join(<38838..39131,39180..>39413)
                     /locus_tag="EHI_194380"
                     /old_locus_tag="46.t00028"
                     /product="hypothetical protein"
                     /note="transcript EHI_194380A"
                     /db_xref="Pathema:EHI_194380"
     CDS             join(38838..39131,39180..39413)
                     /locus_tag="EHI_194380"
                     /old_locus_tag="46.t00028"
                     /note="encoded by transcript EHI_194380A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49312.1"
                     /db_xref="Pathema:EHI_194380"
                     /translation="MDIPVTFSIHYVTSYGEELYIVFDDGVERKMSWSNGHIWTIRCC
                     VLPRLTRWWYEVKQSCVVTRIEKDLHSRQYIFEKDRFYNITDSWDCGAYSMKISKFPK
                     LQKSNTIIFTHPRAVTLPYYNRSPLVRCRIQENNELDNNVPNYKGVRFDSFDDMMIEE
                     TQISSKEGHESVHQQ"
     gene            <39657..40416
                     /locus_tag="EHI_194390"
                     /old_locus_tag="46.t00027"
                     /db_xref="Pathema:EHI_194390"
     mRNA            join(<39657..39941,39989..40416)
                     /locus_tag="EHI_194390"
                     /old_locus_tag="46.t00027"
                     /product="Rho family GTPase"
                     /note="transcript EHI_194390A"
                     /db_xref="Pathema:EHI_194390"
     CDS             join(39657..39941,39989..40339)
                     /locus_tag="EHI_194390"
                     /old_locus_tag="46.t00027"
                     /note="encoded by transcript EHI_194390A;
                     GO_component: GO:0005622 - intracellular;
                     GO_function: GO:0005525 - GTP binding;
                     GO_process: GO:0007264 - small GTPase mediated signal
                     transduction"
                     /codon_start=1
                     /product="Rho family GTPase"
                     /protein_id="EAL49311.1"
                     /db_xref="Pathema:EHI_194390"
                     /translation="MSVKLVAVGDGAVGKTSMLICYTKNEFPEEYIPTVFDNYSTTVT
                     LGDEVISLAIWDTAGQEEYESIRPLSYPSTDVFLLCYSVVQQSSLDNIAEKWLPEVKH
                     HCPSSRTLVVGLKTDLRDSVEEIKKLEAKNQKPIFPNDVQEFIKENNIECDGFCECSA
                     KTQKGLKEVMIQAVRVCVGNGHTKTSTPTPDKDKLKKKSKSSKERKCCVLL"
     gene            complement(<40494..>41326)
                     /locus_tag="EHI_194400"
                     /old_locus_tag="46.t00026"
                     /db_xref="Pathema:EHI_194400"
     mRNA            complement(join(<40494..40849,40942..>41326))
                     /locus_tag="EHI_194400"
                     /old_locus_tag="46.t00026"
                     /product="SNF7 family protein"
                     /note="transcript EHI_194400A"
                     /db_xref="Pathema:EHI_194400"
     CDS             complement(join(40494..40849,40942..41326))
                     /locus_tag="EHI_194400"
                     /old_locus_tag="46.t00026"
                     /note="encoded by transcript EHI_194400A;
                     Reference: Fujita H., Umezuki Y., Imamura K., Ishikawa D.,
                     Uchimura S., Nara A., Yoshimori T., Hayashizaki Y., Kawai
                     J., Ishidoh K., Tanaka Y., Himeno M.; 'Mammalian class E
                     Vps proteins, SBP1 and mVps2/CHMP2A, interact with and
                     regulate the function of an AAA-ATPase SKD1/Vps4B.'; J.
                     Cell Sci. 117:2997-3009(2004). This functional annotation
                     is a direct result of community participation in an
                     Entamoeba Annotation Jamboree;
                     GO_function: GO:0003674 - molecular_function;
                     GO_process: GO:0015031 - protein transport"
                     /codon_start=1
                     /product="SNF7 family protein"
                     /protein_id="EAL49310.1"
                     /db_xref="Pathema:EHI_194400"
                     /translation="MSRLFHKKTPQEIVREQKLNISKSIREITRESKRLEREEVRLTN
                     EIRKMARLGRTNTVKVMAADLVKTKKQIDKLQVVIAQLNSTKMKLTEMSSMVAVTEAM
                     NGVTNAMRKVNEATKLPAMQKVMNDFEKQNAELGIKNTMVSDMVNEGYEGDDIEEETE
                     LEVDKVLTEIGLDVENGLKPVPETRQRNTRLKERRQVQMEGGVKTRNEGNEQPEDLDT
                     PGSRVPKAFNEGEDDEDEDDIVSRIANL"
     gene            <42065..>43141
                     /locus_tag="EHI_194410"
                     /old_locus_tag="46.t00025"
                     /db_xref="Pathema:EHI_194410"
     mRNA            <42065..>43141
                     /locus_tag="EHI_194410"
                     /old_locus_tag="46.t00025"
                     /product="isopentenyl-diphosphate delta-isomerase,
                     putative"
                     /note="transcript EHI_194410A"
                     /db_xref="Pathema:EHI_194410"
     CDS             42065..43141
                     /locus_tag="EHI_194410"
                     /old_locus_tag="46.t00025"
                     /note="encoded by transcript EHI_194410A;
                     GO_function: GO:0004452 - isopentenyl-diphosphate
                     delta-isomerase activity;
                     GO_function: GO:0016491 - oxidoreductase activity;
                     GO_process: GO:0006118 - electron transport"
                     /codon_start=1
                     /product="isopentenyl-diphosphate delta-isomerase,
                     putative"
                     /protein_id="EAL49309.1"
                     /db_xref="Pathema:EHI_194410"
                     /translation="MSLTPSRKLDHLKFCCNNETQSHQSNHLEDIILEKTCFPKQSLS
                     SIQTKINFFNKELSIPLIIGAMTGGSNDVKIVNKTLAIAANETNVAIGVGSQRSGLES
                     NDEEILESYRVVRECAPNAFIIGNIGSVQLTEYGEVLDDLIAMIKGDAIAVHLNWEQE
                     LVQAEGDRNGIDVCRLKEIISKWNGTVIGKQVGHGMMKKDVMICQELGMKAVDIAGIG
                     GTSFAGVECLRAKEKKQYQQNRLGQLLWDFGVPTAMSIWEASQCSLPIIASGGIRNGL
                     EIVKSMTLGASLASITKPFVSLYLEGSEACINYVNFIKNEIQSSLFLCGCPSVNEVHS
                     IPKIITGELYHWMKQRNKMITNNI"
     gene            complement(<43142..>44266)
                     /locus_tag="EHI_194420"
                     /old_locus_tag="46.t00053"
                     /db_xref="Pathema:EHI_194420"
     mRNA            complement(join(<43142..43630,43680..43775,43829..>44266))
                     /locus_tag="EHI_194420"
                     /old_locus_tag="46.t00053"
                     /product="protein kinase domain containing protein"
                     /note="transcript EHI_194420A"
                     /db_xref="Pathema:EHI_194420"
     CDS             complement(join(43142..43630,43680..43775,43829..44266))
                     /locus_tag="EHI_194420"
                     /old_locus_tag="46.t00053"
                     /note="encoded by transcript EHI_194420A;
                     contains PF00069: protein kinase domain This functional
                     annotation is a direct result of community participation
                     in an Entamoeba Annotation Jamboree;
                     GO_function: GO:0016301 - kinase activity;
                     GO_process: GO:0008152 - metabolic process"
                     /codon_start=1
                     /product="protein kinase domain containing protein"
                     /protein_id="EAL49335.1"
                     /db_xref="Pathema:EHI_194420"
                     /translation="MNSRTIQIKNNSYEDPFTQGYALQGLIDKGSEGIVYSILHKKSG
                     QLLACKKIEVGESRINNLRVLQEIRLLKYLNHENIIHLEEYLFAQIESINTVFLVYEL
                     FPRNLSESIKSGRITASTQMKYIVSQLASALYYLHINNFIHRDVKPSNILINDRFKIK
                     LCDFGSCKCLNQKESYPTIQTVCTKIYMPPEYFYEGVEENTTIDIWQLGCVYTQMILR
                     TPPFKGHSVSSIKKSILSLIKPEEIIKINNNEEVNESYGLKETKTILPYFFRTLKIDS
                     SSQELIYDMLQIDPLKRITAIEILQHQSIAMFKQPLGEKESHEFEFVKGNETYDEIVQ
                     LIKNEM"
     gene            <44517..>45086
                     /locus_tag="EHI_194430"
                     /old_locus_tag="46.t00023"
                     /db_xref="Pathema:EHI_194430"
     mRNA            <44517..>45086
                     /locus_tag="EHI_194430"
                     /old_locus_tag="46.t00023"
                     /product="hypothetical protein"
                     /note="transcript EHI_194430A"
                     /db_xref="Pathema:EHI_194430"
     CDS             44517..45086
                     /locus_tag="EHI_194430"
                     /old_locus_tag="46.t00023"
                     /note="encoded by transcript EHI_194430A;
                     GO_function: GO:0005506 - iron ion binding;
                     GO_function: GO:0009055 - electron carrier activity;
                     GO_process: GO:0006118 - electron transport"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49308.2"
                     /db_xref="Pathema:EHI_194430"
                     /translation="MQCPVQVSFNKCIGCLQCIRVCPTKVLTSTHMKSTLSFPERCIS
                     CGCCASVCPVGAIIFNGISPQKIDVESFGDVIPVLKNIEGKVNSDDEEVPKKLISQMI
                     EKAKYSIQSNNYRKLEFKILTDADPKYHQLVCTIGTEKTYDDDVKFLSTLSLILIQNN
                     IHYEWIEFTDPTQNITCALAIGRPKLQHN"
     gene            complement(<45105..>45684)
                     /locus_tag="EHI_194440"
                     /old_locus_tag="46.t00022"
                     /db_xref="Pathema:EHI_194440"
     mRNA            complement(join(<45105..45309,45362..>45684))
                     /locus_tag="EHI_194440"
                     /old_locus_tag="46.t00022"
                     /product="RNA recognition motif domain containing protein"
                     /note="transcript EHI_194440A"
                     /db_xref="Pathema:EHI_194440"
     CDS             complement(join(45105..45309,45362..45684))
                     /locus_tag="EHI_194440"
                     /old_locus_tag="46.t00022"
                     /note="encoded by transcript EHI_194440A;
                     GO_function: GO:0003676 - nucleic acid binding"
                     /codon_start=1
                     /product="RNA recognition motif domain containing protein"
                     /protein_id="EAL49307.2"
                     /db_xref="Pathema:EHI_194440"
                     /translation="MLLLKFMLKNKNEEKKKLKNKKRKGFIMCADLYQTNTNPLKLNT
                     TLNDDKKKQSITLRNVDGKRWVDESMADWPTNDFRMFVGNLGKEVDDTMLKIFFSKYP
                     SVQKVKVIINPYTNKSKGYGFVSFSDPNEYLLALRTLNGKYIGTRPCKLSKGKWEKRA
                     EKSSTKEGKKPKLPK"
     gene            complement(<45927..>46829)
                     /locus_tag="EHI_194450"
                     /old_locus_tag="46.t00021"
                     /db_xref="Pathema:EHI_194450"
     mRNA            complement(<45927..>46829)
                     /locus_tag="EHI_194450"
                     /old_locus_tag="46.t00021"
                     /product="hypothetical protein, conserved"
                     /note="transcript EHI_194450A"
                     /db_xref="Pathema:EHI_194450"
     CDS             complement(45927..46829)
                     /locus_tag="EHI_194450"
                     /old_locus_tag="46.t00021"
                     /note="encoded by transcript EHI_194450A"
                     /codon_start=1
                     /product="hypothetical protein, conserved"
                     /protein_id="EAL49306.1"
                     /db_xref="Pathema:EHI_194450"
                     /translation="MGGQLSIEARLKSIIPQLTFDSHKGACGKVAIIGGSVEYTGAPY
                     FSGISALRVGCDLAHIFCHQDAAIAIKSYSPELIVHPFFKEDYDTNEVLKWLDTVQAL
                     VVGPGLGRDESVMEATLSILKQAITKNIIIILDADGLFLINNHLDLIRGKKNIILTPN
                     VMEYRRLCDVLKVSHNTPCNKVALMLGGVTILQKGQVDEVSNGSYTVHVKHVGSPRRC
                     GGQGDVLSGSLATFVAWSKLNQDFQDEDLICCSVAASALVKECSSFAFTEKHRGVIAS
                     DIIESIPSVFDQVFGQNKIQLIYE"
     gene            complement(46944..48355)
                     /locus_tag="EHI_194460"
                     /note="hypothetical protein, pseudogene"
                     /pseudo
     gene            <48832..>50105
                     /locus_tag="EHI_194470"
                     /old_locus_tag="46.t00018"
                     /db_xref="Pathema:EHI_194470"
     mRNA            join(<48832..49146,49233..>50105)
                     /locus_tag="EHI_194470"
                     /old_locus_tag="46.t00018"
                     /product="hypothetical protein"
                     /note="transcript EHI_194470A"
                     /db_xref="Pathema:EHI_194470"
     CDS             join(48832..49146,49233..50105)
                     /locus_tag="EHI_194470"
                     /old_locus_tag="46.t00018"
                     /note="encoded by transcript EHI_194470A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49305.1"
                     /db_xref="Pathema:EHI_194470"
                     /translation="MSKGKQTVPLSQIVDHATNEIHPSPSIKAYATLAKIAATIPSAQ
                     VALRVQLITKMKAYCNGFLPKKEMYYCLCLVDYLVLNCPQFRPQVLNPDFVTLFERSA
                     DFEKCKKSKKPGIVTEKAMRILQTWGPLYPNELYDYQLMYDKYISKGVYFPVLDKLPE
                     QAQPEHSETLADDLEKSTKEINECSELIQDALENTGASVRTQSVKALYKRAVELNSKF
                     NVLFVKYINTTTNTEEIQKYSELESNFTRLIVQLANIINNPQGEDIYRTYTTGHITDK
                     TEDKHTKLRSSQAPLDPISIATSSAQKETPSPSNFSRKNSSFQLAPPPSRGQPIRFSR
                     QNTEPPESQLFQNSPVPSTKISMETQIRDDTDSVVKNRFIFDQSSPSYQSNHGPLDQQ
                     SLL"
     gene            complement(<50142..>52835)
                     /locus_tag="EHI_194480"
                     /old_locus_tag="46.t00017"
                     /db_xref="Pathema:EHI_194480"
     mRNA            complement(<50142..>52835)
                     /locus_tag="EHI_194480"
                     /old_locus_tag="46.t00017"
                     /product="tyrosine kinase, putative"
                     /note="transcript EHI_194480A"
                     /db_xref="Pathema:EHI_194480"
     CDS             complement(50142..52835)
                     /locus_tag="EHI_194480"
                     /old_locus_tag="46.t00017"
                     /note="encoded by transcript EHI_194480A;
                     GO_function: GO:0004672 - protein kinase activity;
                     GO_function: GO:0004713 - protein-tyrosine kinase
                     activity;
                     GO_function: GO:0005524 - ATP binding;
                     GO_process: GO:0006468 - protein amino acid
                     phosphorylation"
                     /codon_start=1
                     /product="tyrosine kinase, putative"
                     /protein_id="EAL49304.1"
                     /db_xref="Pathema:EHI_194480"
                     /translation="MKNIVLIILYILICYGKLIQVNLEKGNETLDSYIAYIGYNEISE
                     QRHNLPVYWNRRNPTELHWDSTLSTIQNRTATLRIKTVPKRPQIVDMRETIWLLHDQE
                     LYLYSLVSETPTIYLNSTYSGQFDEYAPLVFQHFEKDNIQTDTLITCLNGKLVGIKVE
                     TLTPKITTEYDCGEYISAGSQMVVVKKGQSIKLYQFDASQDEYYIWGTINYYKDILIN
                     GIDTSETFQYDAVRINRYNILYCILSDKNKIVSFDPNSKYSKEEILSNVPFYSDNVTE
                     YIQPLSQQPFDNIGSYGQIIVVGTPGYSINNKIHCGGAYVFFDNYFDYGYEPRFVEVM
                     KISGNYEYQYFGYSVCSSKNSIWLGGLNNIPINFNYPTISISMKNYNKEYCSESNCQC
                     RSNMSFINGKCNSEETKNNNNKITIILIVILLVLIIFIIFILIIVILVIVIPKRKKST
                     KFRIKNFNHDFTSFENFPISFSDTHLDFGFSDKPAPVREEIIQQITIANKTKKKQYFV
                     FNPNEIQSYKYNISFEPKCIKLQPGFGQSVIIKFELLCTTKVNDIIDVVSCEGDEIII
                     GKELHAALTIECESCNSIQLDYQEFEKERVIGEGSFGIVYVGKYRGTQVAIKETKNFS
                     WPQDIIEAFQKEVLMMDKMRCPYIINFVGAVDTLDHYSIITEYAQFGSLKDVYQKNEF
                     SDLLAYKMLNDVAKGMTFLHSSSIIHRDLKPDNILVISMSKDETVNAKLSDFGTTRNV
                     SSSSASDSMTKGIGTPLYMAPEILLNKPYSFPIDVYAFAIVSYEVFLRKIPYGNGCFV
                     HSWDVSDFVSQGHRLDFPKSFSPGICELIKKCWAHDPKQRPVFSEIDRITSKLFKESY
                     KSYEEEKALRKTNSSIQIKPQTQQCNESTSQLGVEIEMNNE"
     gene            complement(<53189..>54414)
                     /locus_tag="EHI_194490"
                     /old_locus_tag="46.t00016"
                     /db_xref="Pathema:EHI_194490"
     mRNA            complement(join(<53189..54318,54396..>54414))
                     /locus_tag="EHI_194490"
                     /old_locus_tag="46.t00016"
                     /product="hypothetical protein"
                     /note="transcript EHI_194490A"
                     /db_xref="Pathema:EHI_194490"
     CDS             complement(join(53189..54318,54396..54414))
                     /locus_tag="EHI_194490"
                     /old_locus_tag="46.t00016"
                     /note="encoded by transcript EHI_194490A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49303.2"
                     /db_xref="Pathema:EHI_194490"
                     /translation="MSVGNDEEIKQEISLNEKIESDNNSNKQDEEQTTQSTPSTPKQS
                     GVSLKELIAQQHQQQKKKEVVMASIFIQRKISESAEEPKRTISCDYSPETKEKHSRLR
                     VEEFFRTILHSNNPCHKLDIPKYLMLPIPSNVLMESIIIPQDTSKIRLLGTAYAAHSN
                     SYATIFTRVYSTHRIILVADPVHTINADYASQQFASLFFKCYETQFSSIISATNTVEA
                     LVETMTDIDIVFSKNKLVPVNFTLLIIFNEDCGFGESKSSVLSLVVGDFNVFKLNKTT
                     GVKKICEEGNYRIGENTKDDAKVYFDWSYFNNDDALIITTTKEFQGVENPEKFLMEKF
                     ESTGVLDSIIKETSTVAVAFSLNIDLWHVHSFMGRPKKEWLKPQMIKA"
     gene            <54745..>55284
                     /locus_tag="EHI_194500"
                     /old_locus_tag="46.t00015"
                     /db_xref="Pathema:EHI_194500"
     mRNA            <54745..>55284
                     /locus_tag="EHI_194500"
                     /old_locus_tag="46.t00015"
                     /product="ADP-ribosylation factor, putative"
                     /note="transcript EHI_194500A"
                     /db_xref="Pathema:EHI_194500"
     CDS             54745..55284
                     /locus_tag="EHI_194500"
                     /old_locus_tag="46.t00015"
                     /note="encoded by transcript EHI_194500A;
                     GO_component: GO:0005622 - intracellular;
                     GO_function: GO:0005525 - GTP binding;
                     GO_process: GO:0007264 - small GTPase mediated signal
                     transduction"
                     /codon_start=1
                     /product="ADP-ribosylation factor, putative"
                     /protein_id="EAL49302.1"
                     /db_xref="Pathema:EHI_194500"
                     /translation="MSFLSFLFKKKQMNILICGLDGAGKTSMLLKMQGQDPKTIQTKP
                     TIGYLNPTLKYKTFEWLFWDVSGAAKFRGLWKSYYPNVKCIAFVFDNTDEDRFDESKN
                     ALLNMLADSELKGMPFLIYVNKTDKKEFDQTTFNEKLGLTETQKLRCQIFPCSAYTGD
                     GLFEGLDWMCYTLKKMTKN"
     gene            <55525..>56406
                     /locus_tag="EHI_194510"
                     /old_locus_tag="46.t00014"
                     /db_xref="Pathema:EHI_194510"
     mRNA            <55525..>56406
                     /locus_tag="EHI_194510"
                     /old_locus_tag="46.t00014"
                     /product="DNA topoisomerase, putative"
                     /note="transcript EHI_194510A"
                     /db_xref="Pathema:EHI_194510"
     CDS             55525..56406
                     /locus_tag="EHI_194510"
                     /old_locus_tag="46.t00014"
                     /note="encoded by transcript EHI_194510A;
                     GO_component: GO:0005694 - chromosome;
                     GO_function: GO:0003677 - DNA binding;
                     GO_function: GO:0003918 - DNA topoisomerase
                     (ATP-hydrolyzing) activity;
                     GO_function: GO:0005524 - ATP binding;
                     GO_process: GO:0006259 - DNA metabolic process;
                     GO_process: GO:0006265 - DNA topological change"
                     /codon_start=1
                     /product="DNA topoisomerase, putative"
                     /protein_id="EAL49301.1"
                     /db_xref="Pathema:EHI_194510"
                     /translation="MKPSKNKYTINSPKQTFINGNINQFVLDKIQTFLLEFISSLNCI
                     TTNKKFVGTSMFIRDHSLIKIAQVFMVLKVIQEATLLNISVTKRHIYYLDKNLFKHQR
                     VVDEIVKKLSEKVFHLPKEDFHIVAAQKSFFCGNITMVRETKTTQITPEKETVIPLIS
                     TMKNTQIKTTATHILIVEKYTVFSQIIKTSWFSMNKNNILIITACGFPDSATKYFINL
                     LISSNQQIKLCCMVDFDPFGLDIFNNYIRLDREYPILSPIRLLFFNYIQQSINNIPSS
                     SKIPLSLIDQKKVCYVN"
     gene            56708..57616
                     /locus_tag="EHI_194520"
                     /old_locus_tag="46.t00056"
                     /db_xref="Pathema:EHI_194520"
     mRNA            56708..57616
                     /locus_tag="EHI_194520"
                     /old_locus_tag="46.t00056"
                     /product="LIM zinc finger domain containing protein"
                     /note="transcript EHI_194520A"
                     /db_xref="Pathema:EHI_194520"
     CDS             56800..57246
                     /locus_tag="EHI_194520"
                     /old_locus_tag="46.t00056"
                     /note="encoded by transcript EHI_194520A;
                     Weak similarity to PFAM HMM accession PF00412, LIM domain;
                     GO_function: GO:0008270 - zinc ion binding"
                     /codon_start=1
                     /product="LIM zinc finger domain containing protein"
                     /protein_id="EAL49338.1"
                     /db_xref="Pathema:EHI_194520"
                     /translation="MSGTPICPTCHKRVYFNERLTFAGKDYHKIGCFKCTSCHKTLEI
                     SKARESDGMPYCVNCHAQKQGLKGFQPGNVLTSYTGYGGGKGEVDNSTVVGGRIAEVA
                     AQEEAEQMRNAPVRSEPAPSDLPKFCPSCGAKNNGGKFCSECGNKF"
     gene            <58397..>60100
                     /locus_tag="EHI_194530"
                     /old_locus_tag="46.t00013"
                     /db_xref="Pathema:EHI_194530"
     mRNA            <58397..>60100
                     /locus_tag="EHI_194530"
                     /old_locus_tag="46.t00013"
                     /product="hypothetical protein"
                     /note="transcript EHI_194530A"
                     /db_xref="Pathema:EHI_194530"
     CDS             58397..60100
                     /locus_tag="EHI_194530"
                     /old_locus_tag="46.t00013"
                     /note="encoded by transcript EHI_194530A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49300.1"
                     /db_xref="Pathema:EHI_194530"
                     /translation="MDKTNIFKELGKPRKKGFGSRDGQLLIQKERTEGLSDDEKNEMK
                     EQKKNKQEESEDSVLFVDDDEVSDKKPEESIIFNEQEDDEIFFDDDDRIIPCDILKSV
                     ECKLRSERMKEKTNFLLTEESQIIRNKFIQYLYDEYYQDRMTPFNELVKGLVKQIDGC
                     LNNIQEFCVNIISIVGMTITNYDYISSIRTTLLSYGRLWRNINIEDTFESTDNIVIII
                     ELPEQEKYIETVWRIAESLRKKLVVFIVGNTTVECDRYLLGHDYPMIKIATISTSTTQ
                     LINHFEYIQLKETIIGKLPLIHPSIISYNIMLYRDFHHSYNLFIQFIIRHIEHSVIFT
                     NPSLIIPQFLDGISEADEKVKLGIEQTYDFLSVIFTRLLFSIQTLSQIQFHKLLPPYT
                     SLLNISDIAQPLFNFNFPSHFNKINIPEDADDELKNIINTINSSPSSETFKLLLDYIS
                     ITIGTIKTFQSNYQSKVECCCVSTKIDFNSFSLFDIIRHCEDGKPKEQQIFTDYRVIL
                     NNVNRKGIISVENCLSLFPDKSPDEIKTLIKELITFGLFVPHNDELRSTEIVITSSIN
                     E"
     gene            <60875..61203
                     /locus_tag="EHI_194540"
                     /db_xref="Pathema:EHI_194540"
     mRNA            <60875..61203
                     /locus_tag="EHI_194540"
                     /product="pore-forming peptide ameobapore B precursor,
                     putative"
                     /note="transcript EHI_194540A"
                     /db_xref="Pathema:EHI_194540"
     CDS             60875..61165
                     /locus_tag="EHI_194540"
                     /note="encoded by transcript EHI_194540A;
                     GO_process: GO:0006629 - lipid metabolic process"
                     /codon_start=1
                     /product="pore-forming peptide ameobapore B precursor,
                     putative"
                     /protein_id="EDS89595.1"
                     /db_xref="Pathema:EHI_194540"
                     /translation="MRAIIFVLIFAIAFAATREGAILCNLCKDTVKLVENLLTVDGAQ
                     AVRQYIDNLCGKASGFLGTLCEKILSFGVDELVKLIENHVDPVVVCEKIHAC"
     gene            61463..>62502
                     /locus_tag="EHI_194550"
                     /old_locus_tag="46.t00057"
                     /db_xref="Pathema:EHI_194550"
     mRNA            61463..>62502
                     /locus_tag="EHI_194550"
                     /old_locus_tag="46.t00057"
                     /product="hypothetical protein"
                     /note="transcript EHI_194550A"
                     /db_xref="Pathema:EHI_194550"
     CDS             61474..62502
                     /locus_tag="EHI_194550"
                     /old_locus_tag="46.t00057"
                     /note="encoded by transcript EHI_194550A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49339.1"
                     /db_xref="Pathema:EHI_194550"
                     /translation="MKALFIALICFCAFAEEDLFNPFIHGKTLLNRMRRIKSSSRRNE
                     RTLLALENRERKIENVLDILYDDMKLAVSIADRMKIETQIDKLHKNLDKIRRQKRAIL
                     RRMKKMADKIALPDRDRLVRSTRTEHRVGIEETSHIRREIENNQKLLLKETQALAHKY
                     AKMAAEIASEKLVKTIDHKNEGDILKAKDKFKKVAKKAYNKYYKKIVERIEEATAEGV
                     VNEDIKMVCRSAIDGLIRKLEHQYLIIVKSRNEAKKEAKKVTKKPLRKSMKTLGKVFK
                     KEITKKTEKDLKKQEKKALDKITKTEKTSSVKAASKTEKKTSTSAKKSKAATEQKKTT
                     KQVQTKKK"
     gene            <62699..>64387
                     /locus_tag="EHI_194560"
                     /old_locus_tag="46.t00008"
                     /db_xref="Pathema:EHI_194560"
     mRNA            <62699..>64387
                     /locus_tag="EHI_194560"
                     /old_locus_tag="46.t00008"
                     /product="hypothetical protein"
                     /note="transcript EHI_194560A"
                     /db_xref="Pathema:EHI_194560"
     CDS             62699..64387
                     /locus_tag="EHI_194560"
                     /old_locus_tag="46.t00008"
                     /note="encoded by transcript EHI_194560A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49347.1"
                     /db_xref="Pathema:EHI_194560"
                     /translation="MESDVQRAGTDKRIRFKEYQCTYPGCNEGLKTKYNCLSHIWDIH
                     LRHLSNITESYKNLPDKEQARSLCIPYLRYVPNADGIRKRKPYDLPDTLINKVDFVSQ
                     NVQNPQQSPLVQPESSFYARSENGYNIKCIDSSDQSTNQTMFPHIESNIVEPLSVNSQ
                     QVQLDTQFGQSSNGIMVTPFTSQLLSLGNDFIRIYSISQNVKRLYVAGEIFAENGFLQ
                     RSDKRSKKDIKKISHALDTICKITGKSFKYVNEDRTRFGFIAQELKEVIPEAVKEDED
                     GRLSIDPLSLLPFIVESLKELQMELKKVIQTETVINLAVAVDNTMKVVNEVKSDNLFS
                     FGPSSFVVPTAVILTFISAIVAIKGTFPFIWIFLVFASICYWASNQFAPNGTFTKQAI
                     TMNFILLNIFLVCVSASFLMGTALQLYLGVYVSLMLLLWGCSQTLNTSFLNFFIVSFS
                     FCCLACWVVFMFQPTFSCSVSTPMKQNTKFREYLEYRNWNDVRFELVSDIPWNCFNPH
                     LDVKGKKVKFVQGNKTTNVVVDPDTLSTDKIEVRMVCSTVPYKCNSYTIYQSID"
     gene            <64992..>66167
                     /locus_tag="EHI_194570"
                     /old_locus_tag="46.t00049"
                     /db_xref="Pathema:EHI_194570"
     mRNA            <64992..>66167
                     /locus_tag="EHI_194570"
                     /old_locus_tag="46.t00049"
                     /product="26S protease regulatory subunit, putative"
                     /note="transcript EHI_194570A"
                     /db_xref="Pathema:EHI_194570"
     CDS             64992..66167
                     /locus_tag="EHI_194570"
                     /old_locus_tag="46.t00049"
                     /note="encoded by transcript EHI_194570A;
                     Reference: Mounkes L.C., Fuller M.T. 'The DUG gene of
                     Drosophila melanogaster encodes a structural and
                     functional homolog of the S. cerevisiae SUG1 predicted
                     ATPase associated with the 26S proteasome.'; Gene
                     206:165-174(1998). This functional annotation is a direct
                     result of community participation in an Entamoeba
                     Annotation Jamboree;
                     GO_function: GO:0005524 - ATP binding;
                     GO_function: GO:0008568 - microtubule-severing ATPase
                     activity"
                     /codon_start=1
                     /product="26S protease regulatory subunit, putative"
                     /protein_id="EAL49331.2"
                     /db_xref="Pathema:EHI_194570"
                     /translation="MEIDGERKSVLKAYLQKLKTYQAKEEALEKIKETLKVSKENMGR
                     NEEMLLSLQTIGMSIGEVLKCLSEEKYIVKVSLGPHYVVGCRSCIDKKKITQGTRVAL
                     DVSTNTIMKILPREVHPAVYSMTVESPGKVKYEDIGGLRNQMREIREVIELPMTNPEL
                     FERVGVKAPKGVLLYGPPGTGKTLLARALASNLECHFLKVVASGIVDKYLGESARLIR
                     EMFAYAREHQPCVIFMDEIDAIAGKRIAEGIHSDREIQRTLMELLAQMDGFNEISKVK
                     IIMATNRPDVLDPALMRPGRLDRKIEISLPNDQGRIEILKIHSKKMNIQEEVDYEAMG
                     KLTEGFNGADLRNVCTEAGMFAIRDDRDYCIEEDFFKAIRKQAEAKKLENQFGDIKI"
     gene            <66241..>67092
                     /locus_tag="EHI_194580"
                     /old_locus_tag="46.t00006"
                     /db_xref="Pathema:EHI_194580"
     mRNA            <66241..>67092
                     /locus_tag="EHI_194580"
                     /old_locus_tag="46.t00006"
                     /product="CAAX amino terminal protease family"
                     /note="transcript EHI_194580A"
                     /db_xref="Pathema:EHI_194580"
     CDS             66241..67092
                     /locus_tag="EHI_194580"
                     /old_locus_tag="46.t00006"
                     /note="encoded by transcript EHI_194580A"
                     /codon_start=1
                     /product="CAAX amino terminal protease family"
                     /protein_id="EAL49345.2"
                     /db_xref="Pathema:EHI_194580"
                     /translation="MNNTSTDNTGNLNTLSKDTKNNQTLPYYQLSKLFVMCGIVCLEF
                     FFIHLILAIVMKGFGLQVYFFQTVICSLVVINFMYYRYSMSGNVITLNTFIQEIFTLK
                     GKWISTLIKAGMGFLSIFCLRVILYYCHIDTSNLFSNFYTDGELDIPVVLDNLFFSVI
                     TEEIALRRSMLNTIKTYTPTSKNYLFIISGIWFGLIHFVNIGTSSFTVTYVLFQMSYG
                     MVIGYTFGIFTEYLGIFPSIILHSMNNACAIFIPFVFSPFLLLYSILSALLLIYLSHK
                     LLISLSL"
     gene            complement(<67589..>70943)
                     /locus_tag="EHI_194590"
                     /old_locus_tag="46.t00005"
                     /db_xref="Pathema:EHI_194590"
     mRNA            complement(join(<67589..70618,70701..>70943))
                     /locus_tag="EHI_194590"
                     /old_locus_tag="46.t00005"
                     /product="hypothetical protein"
                     /note="transcript EHI_194590A"
                     /db_xref="Pathema:EHI_194590"
     CDS             complement(join(67589..70618,70701..70943))
                     /locus_tag="EHI_194590"
                     /old_locus_tag="46.t00005"
                     /note="encoded by transcript EHI_194590A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49344.1"
                     /db_xref="Pathema:EHI_194590"
                     /translation="MSKGIEINKEIKLKSEQWKIPGRAPPSVIAERGMTLKECESAHN
                     FISETIKKLSNLDKLIFYDQYTDDLTPELLYKYQTTDKCYTLILPKEISYQCLDCSDG
                     DLHSFILCSECAEEHKKAGHLLLQHMSNDTEICHCGDIFLEKSKIKVCHIHQHNSIQV
                     NASDESRTTEEINAIKKNVEEIFNRIEIMAQLVIPEMVIQMCDKILDVLSKRYEPDIR
                     VFVLHIVRWLNRVIRINPIRKVIKEVFKTKIKTNGRFLLTNSIEEYQKNNCLYVKRRS
                     QTELINTEVTAHEIFLNLCIMNQPTSSYVARLLYLILDEENKNDFLPEYRRAYATVAF
                     HGTYLPKHLGILLDTIDVKTIIPHILNLLIVVINEKKPLKDRNAMSQFVSWLLADEDN
                     ILDIIQNENNLTTFIELCDQLTFYPTPLDKTTSSVMKLFHPIFIAVMTRIQIVSFKDS
                     FQRNNEEESNSENELIKMHRRVSLLIGKYLKEHAENIVNTLNKIVFGRDQGKTQMNRS
                     VIPSHYYLFSLIGWIANQLMIQPIPNELTNDVFQFLEIGTNEDIKIYLQFSYLIYTIS
                     HDKIYFTSILELKNNKAPQCEVQDYFGELTYPILYSTLIFVSHACLLSLGANRFVDFL
                     REIAYVQEDNLTNQELCVNAVILDFINVICTFSRFGQTPEVNETGFLNYYLYNIKLCT
                     PANSVNSQVKEYIGNALLMAEQTNNTQKILTKNAVPIMKSSIKITRPTSKSSNDRMGL
                     KKYKGEWSKKSIDSRLSMSIMKTTFEKSFKKTVSTKEESTFSKHDITQDVLTNSDITI
                     YQFRKKCDNEPLGIDQSTEVKKEETTKEEYQKMMIKLRMEQKSMTEIKIDQTSFEWPE
                     VAIDPTKRINQPDFFFPFVNASCSISFKINVINKFLLEPISQGRREAFLSFLNPRFTI
                     GNFCVNLQSRINDLLSDKNLNNGLLSKTKMINTTNYIFILRFLWILIVHRRARGITTN
                     DIFLNPHFVKLLCTCYGYFFADIFMLIPENSVEGLLRDITELFSKEPFIIPVTMSRTE
                     KVIHPIKYFIRAVLKNPVSAFFFIDEKGQKKIAEINPLNTGITSLFNEIANQVLVSKK
                     KK"
     gene            complement(<71225..>72823)
                     /locus_tag="EHI_194600"
                     /old_locus_tag="46.t00004"
                     /db_xref="Pathema:EHI_194600"
     mRNA            complement(<71225..>72823)
                     /locus_tag="EHI_194600"
                     /old_locus_tag="46.t00004"
                     /product="molybdenum cofactor sulfurase putative"
                     /note="transcript EHI_194600A"
                     /db_xref="Pathema:EHI_194600"
     CDS             complement(71225..72823)
                     /locus_tag="EHI_194600"
                     /old_locus_tag="46.t00004"
                     /note="encoded by transcript EHI_194600A;
                     Weak similarity to SP:Q8LGM7: Molybdenum cofactor
                     sulfurase (EC 4.4.-.-) (MoCo sulfurase) (MOS). taxon:4081
                     {Solanum lycopersicum;} / %id: 43.3 / coverage: 91.4% This
                     functional annotation is a direct result of community
                     participation in an Entamoeba Annotation Jamboree;
                     GO_function: GO:0008483 - transaminase activity;
                     GO_function: GO:0031071 - cysteine desulfurase activity;
                     GO_process: GO:0008152 - metabolic process"
                     /codon_start=1
                     /product="molybdenum cofactor sulfurase putative"
                     /protein_id="EAL49343.1"
                     /db_xref="Pathema:EHI_194600"
                     /translation="MKVIILLLLTFLINIVYGGYCTQEGCNETLLDKYYSRFSHYNIS
                     IEAMLKEKEEFKKQYSPNNEYGYNNTIEEFVAEELQDRLDNKIFFDYTANGVYTKSQM
                     QKIFENLNSKFYANAHSHNSVSSRTDNAVHEARQLILKRFNVTSAEYTVIFTAGATGA
                     LKLIGESFPWTNNSKFMYLRQNHNSVLGIREYALEQGAEFKTVTEEELTSEGCENLFD
                     EKCDGIPKVLRKPTLTEYPTKVYNLFAFPGTENFAGVKYPLEWINKFGNEKTGKNNNW
                     LVLLDAAAYLSTAKLDLRKYPADFVVMSFYKIMGYPTGIGALLVKNEVMDLMQKSFFG
                     GGTVVMSDCDTHFCLLHESGCQRFEDGTISFLSIASLKYGFEQQDYFGVQNIQNHVMS
                     IVDYLYDKLSNLTHSTGLPVFEIYGKHAKHDHSIQGPIINLSVKDEKGNYVGYSIIEK
                     KLDEAGFQVRTGSSCNPGACYGYLNITSDEVKKFSLLRNGCGDEHDIMEGKPLGGVRI
                     SLGYLSTFEEAYAFVEFFKQNFQH"
     gene            complement(<73102..>74274)
                     /locus_tag="EHI_194610"
                     /old_locus_tag="46.t00003"
                     /db_xref="Pathema:EHI_194610"
     mRNA            complement(join(<73102..74140,74195..>74274))
                     /locus_tag="EHI_194610"
                     /old_locus_tag="46.t00003"
                     /product="hypothetical protein"
                     /note="transcript EHI_194610A"
                     /db_xref="Pathema:EHI_194610"
     CDS             complement(join(73102..74140,74195..74274))
                     /locus_tag="EHI_194610"
                     /old_locus_tag="46.t00003"
                     /note="encoded by transcript EHI_194610A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49342.1"
                     /db_xref="Pathema:EHI_194610"
                     /translation="MLQKFKQHASPLEIELACIFDEELNEPDLLFVKSFDELIALCQK
                     HKQSIKPNVVRSFLINYSSFVSNELVQERSALELLEAINTPLSYGIVSFDTYFPSLQP
                     SGIIEIAGEAGAGKSQICMQIIVLAILCYKIPCYYICDKRFVYQERIDQIEHYFAQLL
                     DFNPVGVNSFLQIHKIQSFDDFEQTLCSLKETNDSGLVIIDCFGTILKTSFEENYNER
                     SVGISRTATILNELNVQGFVVITTNEVVDKIEQTESIPFEFLELYSDLKTLQISTGLD
                     INCDGRVMTSSSGIQWAYFVTHRLFVYKTEESLFSAWDTLSETTQQELDEIDDEMRSN
                     IKIRKCVINKSNEKEKGICLEYCILPSHVCGIERRQLN"
     gene            <74403..>74963
                     /locus_tag="EHI_194620"
                     /old_locus_tag="46.t00002"
                     /db_xref="Pathema:EHI_194620"
     mRNA            <74403..>74963
                     /locus_tag="EHI_194620"
                     /old_locus_tag="46.t00002"
                     /product="hypothetical protein"
                     /note="transcript EHI_194620A"
                     /db_xref="Pathema:EHI_194620"
     CDS             74403..74963
                     /locus_tag="EHI_194620"
                     /old_locus_tag="46.t00002"
                     /note="encoded by transcript EHI_194620A"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="EAL49341.1"
                     /db_xref="Pathema:EHI_194620"
                     /translation="MSCYFLLFIISFISLSFAEENKKLIPDITIKNTQQYNTTFIYQI
                     NPLQLDKNSMYEIKIHSLGSIPTIYGVSLFQPKLYSTNTTFLDESNLQFKTNNNGCVL
                     FDNKTECNPFICYVTLLYMGRTTHIEELNKGVTYFISMKKGILGLPGNVPLLILLGII
                     CLLFAGFTTLFIIKFFTSLEKVNKTN"
     gene            <75223..>78216
                     /locus_tag="EHI_194630"
                     /old_locus_tag="46.t00001"
                     /db_xref="Pathema:EHI_194630"
     mRNA            <75223..>78216
                     /locus_tag="EHI_194630"
                     /old_locus_tag="46.t00001"
                     /product="protein with RhoGEF and ArfGAP domains"
                     /note="transcript EHI_194630A"
                     /db_xref="Pathema:EHI_194630"
     CDS             75223..78216
                     /locus_tag="EHI_194630"
                     /old_locus_tag="46.t00001"
                     /note="encoded by transcript EHI_194630A;
                     GO_component: GO:0005622 - intracellular;
                     GO_function: GO:0005089 - Rho guanyl-nucleotide exchange
                     factor activity;
                     GO_process: GO:0035023 - regulation of Rho protein signal
                     transduction;
                     GO_process: GO:0043087 - regulation of GTPase activity"
                     /codon_start=1
                     /product="protein with RhoGEF and ArfGAP domains"
                     /protein_id="EAL49340.1"
                     /db_xref="Pathema:EHI_194630"
                     /translation="MNYKEEEYKDCIEWINKQLEDDPITDLLSGLQNGIKLIKIVEKL
                     THKSAVRYNSNPKNIFQIQQNMDVLLKMIKENYGEPIGSDATLLANGEIQQFLSLIFF
                     IGQKSGTKIQKRRTLGRNTMNRVIQYQSRLQNETEPFTKKIHNIQEQEQTKEIQHEKQ
                     ITPKKENKPCQTEEVKGIETKKKYSKTRKTQSENLSIIKETNTEEEIKSSIIKESKEL
                     NQKITSEQKDDEILLQPPKVPEKPKKLQHKIHTENESNNDEKINEINQKIEENQIFKS
                     ESSKEKKWIEKEYDINLVKNIQRRIYGFLSRKSSKSTMKLLVQRKNVVKELIKTEEVY
                     VNKLQQFLDLYLKTALTIYPTDKILKKCEEDVIVILGYNKMMYQRVLEVQKKVFYYGQ
                     GIGSVFQKLAHFLKTYCSYVNSTDAINEHEEKLRKTNKQFDYALNEIRRINNLDTFNS
                     YVILPVQRIPRYRLLLQELLKTLPPQHSEYNSLNNSLQAIADIGIVMNESKRTLEIQQ
                     LIGKLTNKFKYSQGINPIEPNASRKFIRFGLITIYEPEAKTKYRSVYLFLFNDTVILT
                     KINSAGTSHKGKIFTETIQTICESKKQLTVELVIPIGSFCVLDSIKIESSPTFLIVNK
                     SGKTIYFICLNEEEKMGWVVDLDNQISQIQEQSLLTISHSNNSLPSFYEEYKNQLSEN
                     TIRDIWWKGPIGSDGKYMILGNGFLCTFSNEEDAFKRIRVNDYFVTKYTSVAFIPPSS
                     ISLINYGTYDKTKSVFDMCCTSLALLWVFYIRQSFIGSYDFEETHLDLFDGIDSDIAG
                     LTVKNIMLGLESIPSNRVCADCGSTDLRYVDLNYGCFLCCACGRAHTLFPTIRNTSNI
                     CTIDKTSEYQVSEIKKLIQFGNGFGNILRLTGKEIPKSSVEYEEANKYQYYWIKYGIE
                     GDAPKCIKSDLKKKQISSEFKRVTVSQTTNNQPSIDTSTIPITELNKEKRNTISSISQ
                     TPITQQPTEKIKRKEGEKKRKKSFY"
     repeat_region   78419..79317
                     /rpt_family="LINE1"
CONTIG      join(AAFB02000684.1:1..6553,gap(100),AAFB02000025.1:1..74020)
//