LOCUS DQ126297 5140 bp DNA linear HUM 27-SEP-2005 DEFINITION Homo sapiens isolate HbA-Ivc04 beta globin (HBB) gene, complete cds. ACCESSION DQ126297 VERSION DQ126297.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5140) AUTHORS Wood,E.T., Stover,D.A., Slatkin,M., Nachman,M.W. and Hammer,M.F. TITLE The beta -globin recombinational hotspot reduces the effects of strong selection around HbC, a recently arisen mutation providing resistance to malaria JOURNAL Am. J. Hum. Genet. 77 (4), 637-642 (2005) PUBMED 16175509 REFERENCE 2 (bases 1 to 5140) AUTHORS Wood,E.T., Stover,D.A., Slatkin,M., Nachman,M.W. and Hammer,M.F. TITLE Direct Submission JOURNAL Submitted (13-JUL-2005) Division of Biotechnology, University of Arizona, BSW 310, Tucson, AZ 85721, USA FEATURES Location/Qualifiers source 1..5140 /organism="Homo sapiens" /mol_type="genomic DNA" /isolate="HbA-Ivc04" /db_xref="taxon:9606" gene <3069..>4492 /gene="HBB" mRNA join(<3069..3160,3291..3513,4364..>4492) /gene="HBB" /product="beta globin" CDS join(3069..3160,3291..3513,4364..4492) /gene="HBB" /codon_start=1 /product="beta globin" /protein_id="AAZ39772.1" /translation="MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFE SFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPE NFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH" BASE COUNT 1540 a 935 c 1027 g 1638 t ORIGIN 1 attaattaat tctgagagct gctgagttgt gtttactgag agattgtgta tctgggagag 61 aagtgtgtag caagtagcta gactgtgctt gacctaggaa catatacagt agattgctaa 121 aatgtctcac ttggggaatt ttagactaaa cagtagagca tgtataaaaa tactctagtc 181 aagtgctgct tttgaaacaa atgataaaag cacactccca tagatgagtg tcacgatttt 241 catggaggaa gttaatattc atcctctaag tatacccaga ctagggccat tctgatataa 301 aacattagga cttaagaaag attaatagac tggagtaaag gaaatggacc tctgtctctc 361 tcgctgtctc ttttttgagg acttgtggtc agtggggctg gaataaaagt agaatagacc 421 tgcacctgct gtggcatcca ttcacagagt agaagcaagc tcacaatagt gaagatgtca 481 gtaagcttga atagtttttc aggaactttg aatgctgatt tagatttgaa actgaggctc 541 tgaccataac caaatttgca ctatttattg cttcttgaaa cttatttgcc tggtatgcct 601 gggcttttga tggtcttagt atagcttgca gccttgtccc tgcagggtat tatgggtaat 661 agaaagaaaa gtctgcgtta cactctagtc acactaagta actaccattg gaaaagcaac 721 ccctgccttg aagccaggat gatggtatct gcagcagttg ccaacacaag agaaggatcc 781 atagttcatc atttaaaaaa gaaaacaaaa tagaaaaagg aaaactattt ctgagcataa 841 gaagttgtag ggtaagtctt taagaaggtg acaatttctg ccaatcagga tttcaaagct 901 gttgctttga caattttggt ctttcagaat actataaata taacctatat tataatttca 961 taaagtctgt gcattttctt tgacccagga tatttgcaaa agacatattc aaacttccgc 1021 agaacacttt atttcacata tacatgcctc ttatatcagg gatgtgaaac agggtcttga 1081 aaactgtcta aatctaaaac aatgctaatg caggtttaaa tttaataaaa taaaatccaa 1141 aatctaaaag ccaagtcaaa tctgtatgtt ttaacattta aaatatttta aagacgtctt 1201 ttcccaggat tcaacatgtg aaatcttttc tcagggatac acgtgtgcct agatcctcat 1261 tgctttagtt ttttacagag gaatgaatat aaaaagaaaa tacttaaatt ttatccctct 1321 tacctctata atcatacata ggcataattt tttaacctag gctccagata gccatagaag 1381 aaccaaacac tttctgcgtg tgtgagaata atcagagtga gattttttca caagtacctg 1441 atgagggttg agacaggtag aaaaagtgag agatctctat ttatttagca ataatagaga 1501 aagtatttaa gagaataaag caatggaaat aagaaatttg taaatttcct tctgataact 1561 agaaatagag gatccagttt cttttggtta acctaaattt tatttcattt tattgtttta 1621 ttttatttta ttttattttg tgtaatcgta gtttcagagt gttagagctg aaaggaagaa 1681 gtaggagaaa catgcaaagt aaaagtataa cactttcctt actaaaccga catgggtttc 1741 caggtagggg caggattcag gatgactgac agggccctta gggaacactg agaccctacg 1801 ctgacctcat aaatgcttgc tacctttgct gttttaatta catcttttaa tagcaggaag 1861 cagaactctg cacttcaaaa gtttttcctc acctgaggag ttaatttagt acaaggggaa 1921 aaagtacagg gggatgggag aaaggcgatc acgttgggaa gctatagaga aagaagagta 1981 aattttagta aaggaggttt aaacaaacaa aatataaaga gaaataggaa cttgaatcaa 2041 ggaaatgatt ttaaaacgca gtattcttag tggactagag gaaaaaaata atctgagcca 2101 agtagaagac cttttcccct cctaccccta ctttctaagt cacagaggct ttttgttccc 2161 ccagacactc ttgcagatta gtccaggcag aaacagttag atgtccccag ttaacctcct 2221 atttgacacc actgattacc ccattgatag tcacactttg ggttgtaagt gactttttat 2281 ttatttgtat ttttgactgc attaagaggt ctctagtttt ttacctcttg tttcccaaaa 2341 cctaataagt aactaatgca cagagcacat tgatttgtat ttattctatt tttagacata 2401 atttattagc atgcatgagc aaattaagaa aaacaacaac aaatgaatgc atatatatgt 2461 atatgtatgt gtgtgtatat atacacatat atatatattt ttcttaccag aaggttttaa 2521 tccaaatcag gagaagatat gcttagaact gaggtagagt tttcatccat tctgtcctgt 2581 aagtattttg catattctgg agacgcagga agagatccat ctacatatcc caaagctgaa 2641 ttatggtaga caaaactctt ccacttttag tgcatcaatt tcttatttgt gtaataagaa 2701 aattgggaaa acgatcttca atatgcttac caagctgtga ttccaaatat tacgtaaata 2761 cacttgcaaa ggaggatgtt tttagtagca atttgtactg atggtatggg gccaagagat 2821 atatcttaga gggagggctg agggtttgaa gtccaactcc taagccagtg ccagaagagc 2881 caaggacagg tacggctgtc atcacttaga cctcaccctg tggagccaca ccctagggtt 2941 ggccaatcta ctcccaggag cagggagggc aggagccagg gctgggcata aaagtcaggg 3001 cagagccatc tattgcttac atttgcttct gacacaactg tgttcactag caacctcaaa 3061 cagacaccat ggtgcacctg actcctgagg agaagtctgc cgttactgcc ctgtggggca 3121 aggtgaacgt ggatgaagtt ggtggtgagg ccctgggcag gttggtatca aggttacaag 3181 acaggtttaa ggagaccaat agaaactggg catgtggaga cagagaagac tcttgggttt 3241 ctgataggca ctgactctct ctgcctattg gtctattttc ccacccttag gctgctggtg 3301 gtctaccctt ggacccagag gttctttgag tcctttgggg atctgtccac tcctgatgct 3361 gttatgggca accctaaggt gaaggctcat ggcaagaaag tgctcggtgc ctttagtgat 3421 ggcctggctc acctggacaa cctcaagggc acctttgcca cactgagtga gctgcactgt 3481 gacaagctgc acgtggatcc tgagaacttc agggtgagtc tatgggaccc ttgatgtttt 3541 ctttcccctt cttttctatg gttaagttca tgtcatagga aggggataag taacagggta 3601 cagtttagaa tgggaaacag acgaatgatt gcatcagtgt ggaagtctca ggatcgtttt 3661 agtttctttt atttgctgtt cataacaatt gttttctttt gtttaattct tgctttcttt 3721 ttttttcttc tccgcaattt ttactattat acttaatgcc ttaacattgt gtataacaaa 3781 aggaaatatc tctgagatac attaagtaac ttaaaaaaaa actttacaca gtctgcctag 3841 tacattacta tttggaatat atgtgtgctt atttgcatat tcataatctc cctactttat 3901 tttcttttat ttttaattga tacataatca ttatacatat ttatgggtta aagtgtaatg 3961 ttttaatatg tgtacacata ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa 4021 aatgctttct tcttttaata tacttttttg tttatcttat ttctaatact ttccctaatc 4081 tctttctttc agggcaataa tgatacaatg tatcatgcct ctttgcacca ttctaaagaa 4141 taacagtgat aatttctggg ttaaggcaat agcaatattt ctgcatataa atatttctgc 4201 atataaattg taactgatgt aagaggtttc atattgctaa tagcagctac aatccagcta 4261 ccattctgct tttattttat ggttgggata aggctggatt attctgagtc caagctaggc 4321 ccttttgcta atcatgttca tacctcttat cttcctccca cagctcctgg gcaacgtgct 4381 ggtctgtgtg ctggcccatc actttggcaa agaattcacc ccaccagtgc aggctgccta 4441 tcagaaagtg gtggctggtg tggctaatgc cctggcccac aagtatcact aagctcgctt 4501 tcttgctgtc caatttctat taaaggttcc tttgttccct aagtccaact actaaactgg 4561 gggatattat gaagggcctt gagcatctgg attctgccta ataaaaaaca tttattttca 4621 ttgcaatgat gtatttaaat tatttctgaa tattttacta aaaagggaat gtgggaggtc 4681 agtgcattta aaacataaag aaatgaagag ctagttcaaa ccttgggaaa atacactata 4741 tcttaaactc catgaaagaa ggtgaggctg caaacagcta atgcacattg gcaacagccc 4801 ctgatgccta tgccttattc atccctcaga aaaggattca agtagaggct tgatttggag 4861 gttaaagttt tgctatgctg tattttacat tacttattgt tttagctgtc ctcatgaatg 4921 tcttttcact acccatttgc ttatcctgca tctctcagcc ttgtctccac tcagttctct 4981 tgcttagaga taccaccttt cccctgaagt gttccttcca tgttttacgg cgagatggtt 5041 tctcctcgcc tggccactca gccttagttg tctctgttgt cttatagagg tctacttgaa 5101 gaaggaaaaa caggggtcat ggtttgactg tcctgtgagc //