LOCUS BK006949 948066 bp DNA linear PLN 25-JUN-2025 DEFINITION TPA_inf: Saccharomyces cerevisiae S288C chromosome XVI, complete sequence. ACCESSION BK006949 VERSION BK006949.2 DBLINK BioProject: PRJNA43747 KEYWORDS Third Party Data; TPA; TPA:inferential. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. REFERENCE 1 (bases 1 to 948066) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 2 (bases 1 to 948066) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (bases 1 to 948066) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 4 (bases 1 to 948066) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REFERENCE 5 (bases 1 to 948066) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (bases 1 to 948066) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter COMMENT THIRD PARTY DATABASE: This TPA record uses data from DDBJ/EMBL/GenBank entries U25840.1, U25841.1, U25842.1, U28371.1, U32445.1, U33335.1, U36624.1, U39205.1, U40828.1, U40829.1, U41849.1, U43281.1, U43503.2, U43703.1, U44030.1, U51033.2, Z48951.1, Z49219.1, Z49274.1, Z49919.1, Z68111.1, Z73502.1, Z73503.1, Z73504.1, Z73505.1, Z73506.1, Z73507.1, Z73508.1, Z73509.1, Z73510.1, Z73511.1, Z73512.1, Z73513.1, Z73514.1, Z73515.1, Z73516.1, Z73517.1, Z73518.1, Z73519.1, Z73520.1, Z73521.1, Z73522.1, Z73523.1, Z73524.1, Z73525.1, Z73526.1, Z73527.1, Z73528.1, Z73529.1, Z73530.1, Z73531.1, Z73532.1, Z73533.1, Z73534.1, Z73535.1, Z73536.1, Z73537.1, Z73538.1, Z73539.1, Z73540.1, Z73541.1, Z73542.1, Z73543.1, Z73544.1, Z73545.1, Z73546.1, Z73547.1, Z73548.1, Z73549.1, Z73550.1, Z73551.1, Z73552.1, Z73554.1, Z73555.1, Z73556.1, Z73557.1, Z73558.1, Z73559.1, Z73560.1, Z73561.1, Z73562.1, Z73563.1, Z73564.1, Z73565.1, Z73566.1, Z73567.1, Z73568.1, Z73569.1, Z73570.1, Z73571.1, Z73572.1, Z73573.1, Z73574.1, Z73575.1, Z73576.1, Z73577.1, Z73578.1, Z73579.1, Z73580.1, Z73581.1, Z73582.1, Z73583.1, Z73584.1, Z73585.1, Z73586.1, Z73587.1, Z73588.1, Z73589.1, Z73590.1, Z73591.1, Z73592.1, Z73594.1, Z73595.1, Z73596.1, Z73597.1, Z73598.1, Z73599.1, Z73600.1, Z73601.1, Z73602.1, Z73603.1, Z73604.1, Z73605.1, Z73606.1, Z73608.1, Z73609.1, Z73610.1, Z73611.1, Z73612.1, Z73613.1, Z73614.1, Z73615.1, Z73617.1, Z73618.1, Z73619.1, Z73620.1, Z73621.1, Z73622.1, Z73623.1, Z73624.1, Z73625.1, Z73626.1, Z73627.1, Z73628.1, Z73629.1, Z73630.1, Z73632.1, Z73633.1, Z73634.1, Z73635.1, Z73636.1, Z73637.1 and Z73638.1 On Apr 18, 2011 this sequence version replaced BK006949.1. ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..948066 /organism="Saccharomyces cerevisiae S288C" /mol_type="genomic DNA" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" telomere complement(1..7223) /note="TEL16L; Telomeric region on the left arm of Chromosome XVI; annotated components include an X element core sequence, X element combinatorial repeats, and a long Y' element; TEL16L does have telomeric repeats (TEL16L-TR), but they are missing from the genome annotation due to difficulties encountered during sequencing and/or assembly" /db_xref="SGD:S000028933" gene complement(280..6007) /gene="YRF1-7" /locus_tag="YPL283C" /gene_synonym="YRF1" mRNA complement(join(280..5840,5989..6007)) /gene="YRF1-7" /locus_tag="YPL283C" /gene_synonym="YRF1" /product="Y' element ATP-dependent helicase protein 1 copy 7" CDS complement(join(280..5840,5989..6007)) /gene="YRF1-7" /locus_tag="YPL283C" /gene_synonym="YRF1" /EC_number="3.6.4.12" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:9837911]" /note="Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p" /codon_start=1 /product="Y' element ATP-dependent helicase protein 1 copy 7" /protein_id="DAA11155.1" /db_xref="SGD:S000006204" /translation="MEIENEQICTCIAQILHLLNSLIITFLDDDKTETGQSFVYIDGF LVKKHNNQHTIVNFETYKNKMKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFES IPTEVRSFYEDEKSGLIKVVKFRTGAMDRKRSFEKIVVSVMVGKNVQKFLTFVEDEPD FQGGPIPSKYLIPKKINLMVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLE RCYEIASARPNDSSTMRTFTDFVSGTPIVRGLQKSTIRKYGYNLAPYMFLLLHVDELS IFSAYQASLPGEKKVDTERLKRDLCPRKPTEIKYFSQICNDMMNKKDRLGDILHIILR ACALNFGAGPRGGAGDEEDRSITNEEPIIPSVDEHGLKVCKLRSPNTPRRLRKTLDAV KALLVSSCACTARDLDIFDDNNGVAMWKWIKILYHEVAQETALKDSYRITLVPSSDGV SVCGKLFNREYVRGFYFACKAQFDNLWEELNDCFYMPTVVDIASLILRNREVLFREPK RGIDEYLENDSFLQMIPVKYREIVLPKLRRDTNKMTAALKNKVTVAIDELTVPLMWMI HFAVGYPYRYPELQLLAFAGPQRNVYVDDTTRRIQLYTDYNKNGSSEPRLKTLDGLTS DYVFYFVTVLRQMQICALGNSYDAFNHDPWMDVVGFEDPDQVTNRDISRIVLYSYMFL NTAKGCLVEYATFRQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESAT SELMANHSVQTGRNIYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSS TRNAEDVVAGEAASSDHHQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQL RLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANC MIRLSRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFR TNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQ RIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVES QPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVS RTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCY LLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSAD TVELIERMDRLAEKQATASMSIVALPSSFQESNSSDRCRKYCSSDEDSDTCIHGSANA STNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTTASTNVRT SATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSNTSATTTASTNS STNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQ MVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDVYFCPEGVFTQYGLCK GCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLK YFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYK VWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQ GPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFCNK TFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPD GRFDILLCRDSSREVGE" gene complement(7933..8427) /gene="PAU22" /locus_tag="YPL282C" mRNA complement(7933..8427) /gene="PAU22" /locus_tag="YPL282C" /product="seripauperin PAU22" CDS complement(7933..8427) /gene="PAU22" /locus_tag="YPL282C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole; identical to Pau21p; encodes two proteins that are translated from two different start codons" /codon_start=1 /product="seripauperin PAU22" /protein_id="DAA11156.1" /db_xref="SGD:S000006203" /translation="MTNEGIGINRDTSTICLREYVFIHFFPVKLISALTNKTNTMVKL TSIAAGVAAIAAGVAAAPATTTLSPSDERVNLVELGVYVSDIRAHLAQYYLFQAAHPT ETYPVEIAEAVFNYGDFTTMLTGIPAEQVTRVITGVPWYSTRLRPAISSALSKDGIYT AIPK" gene complement(9557..10870) /gene="ERR2" /locus_tag="YPL281C" mRNA complement(9557..10870) /gene="ERR2" /locus_tag="YPL281C" /product="phosphopyruvate hydratase ERR2" CDS complement(9557..10870) /gene="ERR2" /locus_tag="YPL281C" /EC_number="4.2.1.11" /experiment="EXISTENCE:direct assay:GO:0004634 phosphopyruvate hydratase activity [PMID:23359425]" /experiment="EXISTENCE:genetic interaction:GO:0004634 phosphopyruvate hydratase activity [PMID:23359425]" /note="Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant" /codon_start=1 /product="phosphopyruvate hydratase ERR2" /protein_id="DAA11157.1" /db_xref="SGD:S000006202" /translation="MSITKVHARTVYDSRGNPTVEVEITTENGLFRAIVPSGASTGIH EAVELRDGNKSEWMGKGVTKAVSNVNSIIGPALIKSELCVTNQKGIDELMISLDGTSN KSRLGANAILGVSLCVARAAAAQKGITLYKYIAELADARQDPFVIPVPFFNVLNGGAH AGGSLAMQEFKIAPVGAQSFAEAMRMGSEVYHHLKILAKEQYGPSAGNVGDEGGVAPD IDTAEDALDMIVEAINICGYEGRVKVGIDSAPSVFYKDGKYDLNFKEPNSDPSHWLSP AQLAEYYHSLLKKYPIISLEDPYAEDDWSSWSAFLKTVNVQIIADDLTCTNKTRIARA IEEKCANTLLLKLNQIGTLTESIEAANQAFDAGWGVMISHRSGETEDPFIADLVVGLR CGQIKSGALSRSERLAKYNELLRIEEELGDDCIYAGHRFHDGNKL" gene 11887..12600 /gene="HSP32" /locus_tag="YPL280W" mRNA 11887..12600 /gene="HSP32" /locus_tag="YPL280W" /product="glutathione-independent methylglyoxalase family protein" CDS 11887..12600 /gene="HSP32" /locus_tag="YPL280W" /EC_number="4.2.1.130" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:24706893]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:24706893|PMID:26777405]" /experiment="EXISTENCE:genetic interaction:GO:0051596 methylglyoxal catabolic process [PMID:27984092]" /experiment="EXISTENCE:mutant phenotype:GO:0031669 cellular response to nutrient levels [PMID:24706893]" /note="Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer" /codon_start=1 /product="glutathione-independent methylglyoxalase family protein" /protein_id="DAA11158.1" /db_xref="SGD:S000006201" /translation="MTPKRALISLTSYHGPFYKDGAKTGVFVVEILRSFDTFEKHGFE VDFVSETGGFGWDEHYLPKSFIGGEDKMNFETKNSAFNKALARIKTANEVNASDYKIF FASAGHGALFDYPKAKNLQDIASKIYANGGVIAAICHGPLLFDGLIDIKTTRPLIEGK AITGFPLEGEIALGVDDILRSRKLTTVERVANKNGAKYLAPIHPWDDYSITDGKLVTG VNANSSYSTTIRAINALYS" gene complement(13228..14355) /gene="FEX2" /locus_tag="YPL279C" mRNA complement(13228..14355) /gene="FEX2" /locus_tag="YPL279C" /product="fluoride transporter" CDS complement(13228..14355) /gene="FEX2" /locus_tag="YPL279C" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:26055717]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:1903424 fluoride transmembrane transport [PMID:24173035|PMID:26055717]" /experiment="EXISTENCE:genetic interaction:GO:1903425 fluoride transmembrane transporter activity [PMID:24173035]" /experiment="EXISTENCE:mutant phenotype:GO:1903424 fluoride transmembrane transport [PMID:26055717]" /note="Protein involved in fluoride export; nearly identical to FEX1, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX domains connected by a linker; part of a widespread family of conserved fluoride export proteins" /codon_start=1 /product="fluoride transporter" /protein_id="DAA11159.1" /db_xref="SGD:S000006200" /translation="MIFNPVISNHKLSHYIHVFCTFTTFCILGTETRQAITALSTYTP AFVTAPTVLWSNCSSCMLMGIMQSLNAYTWMKDHQVLFLGVTTGYCGALSSFSSMLLE MFEHSTNLTNGNIANHTKLPNRAYGIMEFLSVLLVHLMVSMGSLIFGRQLGKEVIVAY GSSSFSKPYTPPSDTVKENAGDVDTQEMEKNILEFKFKTPAPFFKKFFDVVDKLAYAL AFPLIILFVVLCAYYENYSRGKWTLPCLFGIFAGFLRYWLAEMFNKTNKKFPLGTFLA NVFATLLIGIFTMVQRGKKHFSTDIPIVNSLNSCHIVSALISGFCGTLSTISTFINEG YKLSFINMLIYYTVSIGISYCLLVITLGSYAWTRGLTNPIC" gene complement(15053..15355) /locus_tag="YPL278C" mRNA complement(15053..15355) /locus_tag="YPL278C" /product="hypothetical protein" CDS complement(15053..15355) /locus_tag="YPL278C" /note="hypothetical protein; gene expression regulated by copper levels" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11160.1" /db_xref="SGD:S000006199" /translation="MTDNTTSSDLIKNVETARSTIDGLIESLGWIELNYRCERQCNWD EVCYTPSWGPSPMGMTEPGSHNEGFGTHFDESRQRLVINSKLQCININDLMVNRNH" gene complement(15405..16868) /locus_tag="YPL277C" mRNA complement(15405..16868) /locus_tag="YPL277C" /product="hypothetical protein" CDS complement(15405..16868) /locus_tag="YPL277C" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:11935221]" /note="hypothetical protein; localized to the membranes; gene expression regulated by copper levels" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11161.1" /db_xref="SGD:S000006198" /translation="MRFHRQGISAIIGVLLIVLLGFCWKLSGSYGIVSTALPHNQSAI KSTDLPSIRWDNYHEFVRDIDFDNSTAIFNSIRAALRQSPSDIHPVGVSYFPAVIPKG TLMYHAGSKVPTTFEWLAMDHEFSYSFGLRSPSYGRKSLERRHGRFGNGTNGDHPKGP PPPPPPPDEKGRGSQKMLTYRAARDLNKFLYLDGASAAKTDSGEMDTQLMLSNVIKEK LNLTDDGENERMAERLYAARICKWGKPFGLDGIIRVEVGFEVVLCDFSADNVELVSML EMVQPNQYLGLPAPTVISKEEGWPLDENGSLVEDQLTDDQKAILEREDGWEKAFSNFN AVKSFNQLRAGAAHDNGEHRIHIDYRYLVSGINRTYIAPDPNNRRLLDEGMTWEKQLD MVDDLEKALEVGFDATQSMDWQLAFDELVLKFAPLLKSVSNILNSDGDINESIAINAT ALTLNFCLPICEPIPGLKNGCRLFDLVICCQRCRRNC" gene 17948..18385 /locus_tag="YPL276W" /gene_synonym="FDH2" /note="NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate; YPL275W and YPL276W comprise a continuous open reading frame in some S. cerevisiae strains but not in the genomic reference strain S288C" /pseudo /db_xref="SGD:S000006197" mRNA 17948..18385 /locus_tag="YPL276W" /gene_synonym="FDH2" /pseudo /db_xref="SGD:S000006197" gene 18369..19079 /gene="FDH2" /locus_tag="YPL275W" /note="NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate; YPL275W and YPL276W comprise a continuous open reading frame in some S. cerevisiae strains but not in the genomic reference strain S288C" /pseudo /db_xref="SGD:S000006196" mRNA 18369..19079 /gene="FDH2" /locus_tag="YPL275W" /pseudo /db_xref="SGD:S000006196" rep_origin 18370..19069 /gene="FDH2" /locus_tag="YPL275W" /note="ARS1603; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay" /db_xref="SGD:S000130195" gene 22938..24701 /gene="SAM3" /locus_tag="YPL274W" mRNA 22938..24701 /gene="SAM3" /locus_tag="YPL274W" /product="bifunctional polyamine/amino acid permease SAM3" CDS 22938..24701 /gene="SAM3" /locus_tag="YPL274W" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17218313]" /experiment="EXISTENCE:direct assay:GO:0015489 putrescine transmembrane transporter activity [PMID:17218313]" /experiment="EXISTENCE:direct assay:GO:0015606 spermidine transmembrane transporter activity [PMID:17218313]" /experiment="EXISTENCE:direct assay:GO:0015847 putrescine transport [PMID:17218313]" /experiment="EXISTENCE:direct assay:GO:0015848 spermidine transport [PMID:17218313]" /experiment="EXISTENCE:mutant phenotype:GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity [PMID:10497160]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:10497160]" /experiment="EXISTENCE:mutant phenotype:GO:0015489 putrescine transmembrane transporter activity [PMID:17218313]" /experiment="EXISTENCE:mutant phenotype:GO:0015606 spermidine transmembrane transporter activity [PMID:17218313]" /experiment="EXISTENCE:mutant phenotype:GO:0015805 S-adenosyl-L-methionine transport [PMID:10497160]" /experiment="EXISTENCE:mutant phenotype:GO:0015847 putrescine transport [PMID:17218313]" /experiment="EXISTENCE:mutant phenotype:GO:0015848 spermidine transport [PMID:17218313]" /note="High-affinity S-adenosylmethionine permease; required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p" /codon_start=1 /product="bifunctional polyamine/amino acid permease SAM3" /protein_id="DAA11162.1" /db_xref="SGD:S000006195" /translation="MDILKRGNESDKFTKIETESTTIPNDSDRSGSLIRRMKDSFKQS NLHVIPEDLENSEQTEQEKIQWKLASQPYQKVLSQRHLTMIAIGGTLGTGLFIGLGYS LASGPAALLIGFLLVGTSMFCVVQSAAELSCQFPVSGSYATHVSRFIDESVGFTVATN YALAWLISFPSELIGCALTISYWNQTVNPAVWVAIFYVFIMVLNLFGVRGFAETEFAL SIIKVIAIFIFIIIGIVLIAGGGPNSTGYIGAKYWHDPGAFAKPVFKNLCNTFVSAAF SFGGSELVLLTSTESKNISAISRAAKGTFWRIAIFYITTVVIIGCLVPYNDPRLLSGS NSEDVSASPFVIALSNTGSMGAKVSNFMNVVILVAVVSVCNSCVYASSRLIQALGASG QLPSVCSYMDRKGRPLVGIGISGAFGLLGFLVASKKEDEVFTWLFALCSISSFFTWFC ICMSQIRFRMALKAQGRSNDEIAYKSILGVYGGILGCVLNALLIAGEIYVSAAPVGSP SSAEAFFEYCLSIPIMIVVYFAHRFYRRDWKHFYIKRSEIDLDTGCSVENLELFKAQK EAEEQLIASKPFYYKIYRFWC" gene 25087..26064 /gene="SAM4" /locus_tag="YPL273W" mRNA 25087..26064 /gene="SAM4" /locus_tag="YPL273W" /product="S-adenosylmethionine-homocysteine S-methyltransferase SAM4" CDS 25087..26064 /gene="SAM4" /locus_tag="YPL273W" /EC_number="2.1.1.10" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity [PMID:11013242]" /experiment="EXISTENCE:direct assay:GO:0019284 L-methionine salvage from S-adenosylmethionine [PMID:14189892]" /experiment="EXISTENCE:direct assay:GO:0046498 S-adenosylhomocysteine metabolic process [PMID:14189892]" /experiment="EXISTENCE:direct assay:GO:0050667 homocysteine metabolic process [PMID:14189892]" /note="S-adenosylmethionine-homocysteine methyltransferase; functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio; SAM4 has a paralog, YMR321C, that arose from a single-locus duplication" /codon_start=1 /product="S-adenosylmethionine-homocysteine S-methyltransferase SAM4" /protein_id="DAA11163.1" /db_xref="SGD:S000006194" /translation="MARLPLKQFLADNPKKVLVLDGGQGTELENRGIKVANPVWSTIP FISESFWSDESSANRKIVKEMFNDFLNAGAEILMTTTYQTSYKSVSENTPIRTLSEYN NLLNRIVDFSRNCIGEDKYLIGCIGPWGAHICREFTGDYGAEPENIDFYQYFKPQLEN FNKNDKLDLIGFETIPNIHELKAILSWDESILSRPFYIGLSVHEHGVLRDGTTMEEIA QVIKDLGDKINPNFSFLGINCVSFNQSPDILESLHQALPNMALLAYPNSGEVYDTEKK IWLPNSDKLNSWDTVVKQYISSGARIIGGCCRTSPKDIQEISAAVKKYT" gene complement(26611..28164) /gene="PBI1" /locus_tag="YPL272C" mRNA complement(26611..28164) /gene="PBI1" /locus_tag="YPL272C" /product="Pbi1p" CDS complement(26611..28164) /gene="PBI1" /locus_tag="YPL272C" /note="hypothetical protein; gene expression induced in response to ketoconazole; YPL272C is not an essential gene" /codon_start=1 /product="Pbi1p" /protein_id="DAA11164.1" /db_xref="SGD:S000006193" /translation="MTTFRPLSSFEKKILTQSLNDQRNGTIFSSTYSKSLSRENDADW HSDEVTLGTNSSKDDSRLTLPLIATTLKRLIKSQPALFATVNEEWEFEPLKQLKTSDI VNVIEFETIKDKEVNCHWGVPPPYLLRHAFNKTRFVPGSNKPLWTLYVIDEALLVFHG HDVLFDIFSAANFHKLFLKELNEISTVTHSEDRILFDVNDINLSELKFPKSIYDSAKL HLPAMTPQIFHKQTQSFFKSIYYNTLKRPFGYLTNQTSLSSSVSATQLKKYNDILNAH TSLCGTTVFGIVNNQRFNYLKSIVNQEHICLRSFICGIAMICLKPLVKDFSGTIVFTI PINLRNHLGLGGSLGLFFKELRVECPLSLIDDELSANEFLTNSNDNEDNDDEFNERLM EYQFNKVTKHVSGFIMAKLRSWEKNGFNDDDIRRMKYDNDDDFHIQNSRTKLIQINDV SDISLSMNGDDKSFKIVSTGFTSSINRPTLMSLSYTYCEEMGLNICIHYPDSYNLESF VECFESFIE" gene 30079..30267 /gene="ATP15" /locus_tag="YPL271W" mRNA 30079..30267 /gene="ATP15" /locus_tag="YPL271W" /product="F1F0 ATP synthase subunit epsilon" CDS 30079..30267 /gene="ATP15" /locus_tag="YPL271W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:15294286|PMID:18722382]" /experiment="EXISTENCE:direct assay:GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) [PMID:15294286]" /experiment="EXISTENCE:direct assay:GO:0045269 proton-transporting ATP synthase, central stalk [PMID:17082766]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:8416924]" /experiment="EXISTENCE:mutant phenotype:GO:0045269 proton-transporting ATP synthase, central stalk [PMID:8416924]" /experiment="EXISTENCE:mutant phenotype:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:8416924]" /note="Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated" /codon_start=1 /product="F1F0 ATP synthase subunit epsilon" /protein_id="DAA11165.1" /db_xref="SGD:S000006192" /translation="MSAWRKAGISYAAYLNVAAQAIRSSLKTELQTASVLNRSQTDAF YTQYKNGTAASEPTPITK" gene 30482..32803 /gene="MDL2" /locus_tag="YPL270W" mRNA 30482..32803 /gene="MDL2" /locus_tag="YPL270W" /product="ATP-binding cassette permease MDL2" CDS 30482..32803 /gene="MDL2" /locus_tag="YPL270W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11251115]" /note="Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response to H2O2; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis" /codon_start=1 /product="ATP-binding cassette permease MDL2" /protein_id="DAA11166.1" /db_xref="SGD:S000006191" /translation="MLNGRLPLLRLGICRNMLSRPRLAKLPSIRFRSLVTPSSSQLIP LSRLCLRSPAVGKSLILQSFRCNSSKTVPETSLPSASPISKGSARSAHAKEQSKTDDY KDIIRLFMLAKRDWKLLLTAILLLTISCSIGMSIPKVIGIVLDTLKTSSGSDFFDLKI PIFSLPLYEFLSFFTVALLIGCAANFGRFILLRILSERVVARLRANVIKKTLHQDAEF FDNHKVGDLISRLGSDAYVVSRSMTQKVSDGVKALICGVVGVGMMCSLSPQLSILLLF FTPPVLFSASVFGKQIRNTSKDLQEATGQLTRVAEEQLSGIKTVQSFVAEGNELSRYN VAIRDIFQVGKTAAFTNAKFFTTTSLLGDLSFLTVLAYGSYLVLQSQLSIGDLTAFML YTEYTGNAVFGLSTFYSEIMQGAGAASRLFELTDRKPSISPTVGHKYKPDRGVIEFKD VSFSYPTRPSVQIFKNLNFKIAPGSSVCIVGPSGRGKSTIALLLLRYYNPTTGTITID NQDISKLNCKSLRRHIGIVQQEPVLMSGTIRDNITYGLTYTPTKEEIRSVAKQCFCHN FITKFPNTYDTVIGPHGTLLSGGQKQRIAIARALIKKPTILILDEATSALDVESEGAI NYTFGQLMKSKSMTIVSIAHRLSTIRRSENVIVLGHDGSVVEMGKFKELYANPTSALS QLLNEKAAPGPSDQQLQIEKVIEKEDLNESKEHDDQKKDDNDDNDNNHDNDSNNQSPE TKDNNSDDIEKSVEHLLKDAAKEANPIKITPQP" gene 33013..34947 /gene="KAR9" /locus_tag="YPL269W" mRNA 33013..34947 /gene="KAR9" /locus_tag="YPL269W" /product="Kar9p" CDS 33013..34947 /gene="KAR9" /locus_tag="YPL269W" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:26906737]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26906737]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:26906737]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:20534809]" /experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:26906737]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:9442113]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:9442113]" /experiment="EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:24850890]" /experiment="EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:9442113]" /experiment="EXISTENCE:mutant phenotype:GO:0051293 establishment of spindle localization [PMID:22385961]" /note="Spindle positioning factor; orients astral microtubules, connecting them to actin cables at the cortex with Bim1p and Myo2, resulting in proper spindle positioning; targeted for StuBL-dependent degradation at kinetochores by Slx5p-Slx8p, ensuring chromosome transmission fidelity and correct spindle positioning; role in karyogamy; localizes to the shmoo tip, the growing bud-tip, the nucleus, the kinetochore, the spindle and microtubules; homolog of adenomatous polyposis coli" /codon_start=1 /product="Kar9p" /protein_id="DAA11167.1" /db_xref="SGD:S000006190" /translation="MDNDGPRSMTIGDDFQENFCERLERIHNTLHSINDCNSLNESTT SISETLLVQFYDDLENVASVIPDLVNKKRLGKDDILLFMDWLLLKKYMLYQFISDVHN IEEGFAHLLDLLEDEFSKDDQDSDKYNRFSPMFDVIEESTQIKTQLEPWLTNLKELLD TSLEFNEISKDHMDTLHKIINSNISYCLEIQEERFASPIRHTPSFTLEQLVKLLGTHT ETTEPKVPKFSPAEDILSRKFLNLKKNIPPIEKSLTDILPQRIVQFGHRNITNITTLQ TILQKKYELIMKDYRFMNSEFRELKVELIDKRWNILFINLNHELLYILDEIERLQSKL LTTKYTKDITIRLERQLERKSKTVSKTFNIIYRALEFSLLDAGVASKTNELAQRWLNI KPTADKILIKSSASNKIATSKKKIPKPKSLGFGRPNSVIGTITQDFQERVAINEGDSN KTPENSTTVALKGKKLGKALLQKMNIKPATSPNSSNAINPFFDPESPNKGKLILSSVP PLPYDETDETTLRVSRGENEKSPDSFITSRHENKVQITETPLMAKNKSVLDIEKDKWN HYRSLPSRIPIYKDKVVKVTVENTPIAKVFQTPPTKITTPNSQVWVPSTRRRTRLRPP TPLSQLLSPREGRLDKTPTY" gene 35236..37845 /gene="PLC1" /locus_tag="YPL268W" mRNA 35236..37845 /gene="PLC1" /locus_tag="YPL268W" /product="phosphatidylinositol phospholipase C" CDS 35236..37845 /gene="PLC1" /locus_tag="YPL268W" /EC_number="3.1.4.11" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:10779349|PMID:12756538]" /experiment="EXISTENCE:direct assay:GO:0004435 phosphatidylinositol phospholipase C activity [PMID:15485855|PMID:8395015]" /experiment="EXISTENCE:direct assay:GO:0009395 phospholipid catabolic process [PMID:8395015]" /experiment="EXISTENCE:genetic interaction:GO:0001402 signal transduction involved in filamentous growth [PMID:10514491]" /experiment="EXISTENCE:mutant phenotype:GO:0004435 phosphatidylinositol phospholipase C activity [PMID:9784626|PMID:7753023]" /experiment="EXISTENCE:mutant phenotype:GO:0009395 phospholipid catabolic process [PMID:7753023]" /experiment="EXISTENCE:mutant phenotype:GO:0032958 inositol phosphate biosynthetic process [PMID:10390371]" /experiment="EXISTENCE:mutant phenotype:GO:0034501 protein localization to kinetochore [PMID:19205744]" /experiment="EXISTENCE:physical interaction:GO:0000776 kinetochore [PMID:10779349]" /experiment="EXISTENCE:physical interaction:GO:0001402 signal transduction involved in filamentous growth [PMID:10514491]" /note="Phospholipase C; hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes; Plc1p and inositol polyphosphates are required for acetyl-CoA homeostasis which regulates global histone acetylation" /codon_start=1 /product="phosphatidylinositol phospholipase C" /protein_id="DAA11168.1" /db_xref="SGD:S000006189" /translation="MTESAIDDQRFNLTKELQRHSCRDQGKITQKDDALDFISYSSFQ SSFNTDQKSANNGSTVRRSIRSIFRRAAELPRVHMGPLTYSHGINELVNKKLRKDCDL STLCRVLQRGIRMIRMTRRRRKFYEFKLINNNGQIIWKDGSKYLELDSVKDIRIGDTA STYQEEVDPKRLRSDSKLWIAIIYKVSNKLKALHVVALNELDFNTFLSCICGLVKLRR ELMESILLPDNSQFARIHWQITVSEKEEDEKKDTLSFADVKKLCDKFHIYVSTGQLLE FFQLADINHNGLLNYFEFEKFIKILKNRKEVNMIWSKFTKPPHSHLSFENFFQFLITE QHEQVDRQTAWSYFIKYREPTQLTMGQDGFTKFLKEQPYLVEVKEELYSKPLNHYFIA SSHNTYLLGKQIAETPSVEGYIQVLQQGCRCVEIDIWDGENGPVVCHGFLTSAIPLKT VIRVIKKYAFITSPYPLIISLEINCNKDNQKLASLIMREVLAEQLYFVGTRTDKLPSP RELKHKILLKSKKTSEATRGLSVNEPFPSSFSSSYESANEQELRMKDDSTNSSSATNS SSMQRIKRIGLKKHADIINDVSNISGIHGIKFRNFSLPESKTIAHCFSLNERKVEYMI KDKHLKLSLDKHNRRYLMRVYPHVLRYKSSNFNPIPFWKAGVQMVATNWQTNDIGQQL NLAMFQILDHQPDGSFKSGYVLKPKKLLPVVTKAKMIPLIYEHFENGSDPVTVKIRIL STQLLPRLNDTSPSRNNTNSFVKVEFHTDDEPTMPISIDKGTRISATEASTKSSQGNG FNPIWDAEVSITLKDTDLTFIKFMVISEETQIASVCLKLNYLRMGYRHIPLFNMEGEQ YIFCTLFIHTQIL" gene 38169..38798 /gene="ACM1" /locus_tag="YPL267W" mRNA 38169..38798 /gene="ACM1" /locus_tag="YPL267W" /product="Acm1p" CDS 38169..38798 /gene="ACM1" /locus_tag="YPL267W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18498748]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18498748]" /experiment="EXISTENCE:direct assay:GO:0031397 negative regulation of protein ubiquitination [PMID:18519589|PMID:18596038]" /experiment="EXISTENCE:direct assay:GO:0055105 ubiquitin-protein transferase inhibitor activity [PMID:18596038|PMID:18498748|PMID:18519589]" /experiment="EXISTENCE:genetic interaction:GO:0055105 ubiquitin-protein transferase inhibitor activity [PMID:18498748]" /experiment="EXISTENCE:mutant phenotype:GO:0055105 ubiquitin-protein transferase inhibitor activity [PMID:18596038|PMID:18498748]" /note="Pseudosubstrate inhibitor of the APC/C; suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein; the anaphase-promoting complex/cyclosome is also known as APC/C" /codon_start=1 /product="Acm1p" /protein_id="DAA11169.1" /db_xref="SGD:S000006188" /translation="MISPSKKRTILSSKNINQKPRAVVKGNELRSPSKRRSQIDTDYA LRRSPIKTIQISKAAQFMLYEETAEERNIAVHRHNEIYNNNNSVSNENNPSQVKENLS PAKICPYERAFLREGGRIALKDLSVDEFKGYIQDPLTDETIPLTLPLGDKKISLPSFI TPPRNSKISIFFTSKHQGQNPETKISRSTDDVSEKKVVRKLSFHVYEDE" gene 39121..40077 /gene="DIM1" /locus_tag="YPL266W" /gene_synonym="CDH1" mRNA 39121..40077 /gene="DIM1" /locus_tag="YPL266W" /gene_synonym="CDH1" /product="putative dimethyladenosine transferase" CDS 39121..40077 /gene="DIM1" /locus_tag="YPL266W" /gene_synonym="CDH1" /EC_number="2.1.1.183" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:mutant phenotype:GO:0000154 rRNA modification [PMID:8064863]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:8064863]" /note="Essential 18S rRNA dimethylase (dimethyladenosine transferase); responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing; human homolog DIMT1 complements yeast dim1 mutant" /codon_start=1 /product="putative dimethyladenosine transferase" /protein_id="DAA11170.1" /db_xref="SGD:S000006187" /translation="MGKAAKKKYSGATSSKQVSAEKHLSSVFKFNTDLGQHILKNPLV AQGIVDKAQIRPSDVVLEVGPGTGNLTVRILEQAKNVVAVEMDPRMAAELTKRVRGTP VEKKLEIMLGDFMKTELPYFDICISNTPYQISSPLVFKLINQPRPPRVSILMFQREFA LRLLARPGDSLYCRLSANVQMWANVTHIMKVGKNNFRPPPQVESSVVRLEIKNPRPQV DYNEWDGLLRIVFVRKNRTISAGFKSTTVMDILEKNYKTFLAMNNEMVDDTKGSMHDV VKEKIDTVLKETDLGDKRAGKCDQNDFLRLLYAFHQVGIHFS" gene 41043..42869 /gene="DIP5" /locus_tag="YPL265W" mRNA 41043..42869 /gene="DIP5" /locus_tag="YPL265W" /product="dicarboxylic amino acid permease" CDS 41043..42869 /gene="DIP5" /locus_tag="YPL265W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005310 dicarboxylic acid transmembrane transporter activity [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006865 amino acid transport [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress" /codon_start=1 /product="dicarboxylic amino acid permease" /protein_id="DAA11171.1" /db_xref="SGD:S000006186" /translation="MKMPLKKMFTSTSPRNSSSLDSDHDAYYSKQNPDNFPVKEQEIY NIDLEENNVSSRSSTSTSPSARDDSFAVPDGKDENTRLRKDLKARHISMIAIGGSLGT GLLIGTGTALLTGGPVAMLIAYAFVGLLVFYTMACLGEMASYIPLDGFTSYASRYVDP ALGFAIGYTYLFKYFILPPNQLTAAALVIQYWISRDRVNPGVWITIFLVVIVAINVVG VKFFGEFEFWLSSFKVMVMLGLILLLFIIMLGGGPNHDRLGFRYWRDPGAFKEYSTAI TGGKGKFVSFVAVFVYSLFSYTGIELTGIVCSEAENPRKSVPKAIKLTVYRIIVFYLC TVFLLGMCVAYNDPRLLSTKGKSMSAAASPFVVAIQNSGIEVLPHIFNACVLVFVFSA CNSDLYVSSRNLYALAIDGKAPKIFAKTSRWGVPYNALILSVLFCGLAYMNVSSGSAK IFNYFVNVVSMFGILSWITILIVYIYFDKACRAQGIDKSKFAYVAPGQRYGAYFALFF CILIALIKNFTVFLGHKFDYKTFITGYIGLPVYIISWAGYKLIYKTKVIKSTDVDLYT FKEIYDREEEEGRMKDQEKEERLKSNGKNMEWFYEKFLGNIF" rep_origin 42977..43212 /note="ARS1604; Autonomously Replicating Sequence" /db_xref="SGD:S000118411" gene complement(43283..44344) /locus_tag="YPL264C" mRNA complement(43283..44344) /locus_tag="YPL264C" /product="hypothetical protein" CDS complement(43283..44344) /locus_tag="YPL264C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:31945465]" /note="Endoplasmic reticulum hypothetical protein; physically interacts with Hsp82p; YPL264C is not an essential gene" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11172.1" /db_xref="SGD:S000006185" /translation="MTLQRISKDYLKPNYGLILLIVSYFFNSSMVVSTKVLENDPLET SQSRINPLQILLVRMSITYCCTLVYMHWNKQSVPDIPWGPAPCRKWLILRGIMGFFGV FGMYFSLMYLSISDAVLITFMSPTLTIFLSFLLLGEPFSKLEALGSLISFSGVVLIIR PTFLFGEQTQGQQSPQDDIVETQNPKLRLIAIGVSLLGVCGLSSVYIIIRYIGNKAHA IMSVSYFSLVTTVVAALGVLLIPSMSLQLPHSWKQWGLFLNLGISGFIHQILLTMGIQ RERAGRGSLMTYTQVIYAVFWDVVLFHHWPNIWTWCGMAVIVSSTIWVINMRASKQNV VATAELLSTSDFELDDLED" gene complement(44551..46506) /gene="KEL3" /locus_tag="YPL263C" mRNA complement(44551..46506) /gene="KEL3" /locus_tag="YPL263C" /product="Kel3p" CDS complement(44551..46506) /gene="KEL3" /locus_tag="YPL263C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Cytoplasmic hypothetical protein" /codon_start=1 /product="Kel3p" /protein_id="DAA11173.1" /db_xref="SGD:S000006184" /translation="MAKKNKKDKEAKKARAELKNQKNQKKQEKKFQKNKNKSLNGEED DESDQDLDEILSSFSKKQIELEHVDITSVEKPSCRTHPLMFANPQHNKHELFIFGGEF TDPETKLTHFYNDLYSYSIKNNSWKKYVSQNAPLPRSSAAVAVHPSGIALLHGGEFSS PKQSKFYHYSDTWLFDCVERKFTKLEFGGRDSSPSARSGHRIIAWKNYFILFGGFRDL GNGQTSYLNDLWCFDISTYKWTKLETNSKPDARSGHCFIPTDNSAILMGGYCKIIAKN NKNLMKGKILNDAWKLNLTPDPKKWQWEKLKNFKNQPSPRVGYSFNLWKQNKSVAFGG VYDLQETEESLESVFYNDLYMFHLELNKWSKLRIKPQRQTNSKNSPATSKRKSNKDQE KELQDLLNSILAKSNLNDDDDDNDDNSTTGPNSIDDDEDNEDDSDLDNQEDITISNQL PHPRFNAATCVVGDSLFIYSGVWELGEKDYPINSFYSIDLNKLDGVKVYWEDLSAIEE AKRLGDRDSDEDEFEYEDDEEDEDDGEEEQDAGPLEGDEDEESESDDDKQAQMEIPDE RSWLPHPKPFETLRAFYLREGANFLTWSISNNRNLKGKQLKTKSFELCEDRWWERRDQ VTLEEERLEDTGGIIERDTTTKPSKRR" gene 47336..48802 /gene="FUM1" /locus_tag="YPL262W" mRNA 47336..48802 /gene="FUM1" /locus_tag="YPL262W" /product="fumarase FUM1" CDS 47336..48802 /gene="FUM1" /locus_tag="YPL262W" /EC_number="4.2.1.2" /experiment="EXISTENCE:direct assay:GO:0004333 fumarate hydratase activity [PMID:3040736]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:20231875]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:11502169]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:11585823]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11585823]" /experiment="EXISTENCE:mutant phenotype:GO:0006099 tricarboxylic acid cycle [PMID:1587456]" /experiment="EXISTENCE:mutant phenotype:GO:0006106 fumarate metabolic process [PMID:1587456]" /note="Fumarase; converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria" /codon_start=1 /product="fumarase FUM1" /protein_id="DAA11174.1" /db_xref="SGD:S000006183" /translation="MLRFTNCSCKTFVKSSYKLNIRRMNSSFRTETDAFGEIHVPADK YWGAQTQRSFQNFKIGGARERMPLPLVHAFGVLKKSAAIVNESLGGLDPKISKAIQQA ADEVASGKLDDHFPLVVFQTGSGTQSNMNANEVISNRAIEILGGKIGSKQVHPNNHCN QSQSSNDTFPTVMHIAASLQIQNELIPELTNLKNALEAKSKEFDHIVKIGRTHLQDAT PLTLGQEFSGYVQQVENGIQRVAHSLKTLSFLAQGGTAVGTGLNTKPGFDVKIAEQIS KETGLKFQTAPNKFEALAAHDAIVECSGALNTLACSLFKIAQDIRYLGSGPRCGYHEL MLPENEPGSSIMPGKVNPTQNEALTQVCVQVMGNNAAITFAGSQGQFELNVFKPVMIA NLLNSIRLITDAAYSFRVHCVEGIKANEPRIHELLTKSLMLVTALNPKIGYDAASKVA KNAHKKGITLKESALELGVLTEKEFDEWVVPEHMLGPK" gene complement(48996..49304) /locus_tag="YPL261C" mRNA complement(48996..49304) /locus_tag="YPL261C" /product="hypothetical protein" CDS complement(48996..49304) /locus_tag="YPL261C" /note="hypothetical protein; conserved among S. cerevisiae strains; YPL261C is not an essential gene; partially overlaps verified ORF YPL260W" /codon_start=1 /product="hypothetical protein" /protein_id="DAA80341.1" /db_xref="SGD:S000006182" /translation="MLFLDSYSLLIQFQRFKNWESPRRFSSSFPLLLFVFKPIFAAKL LKEICSSGVLSYSLSFLKIPLSVMRVILGPLPDDKKLKNDAKYSFMNYFIITCIGIIM " gene 49303..50958 /gene="CUB1" /locus_tag="YPL260W" mRNA 49303..50958 /gene="CUB1" /locus_tag="YPL260W" /product="Cub1p" CDS 49303..50958 /gene="CUB1" /locus_tag="YPL260W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Conserved fungal gene linked to DNA repair and proteasome function; putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="Cub1p" /protein_id="DAA11175.1" /db_xref="SGD:S000006181" /translation="MFASAGQQHPQIVPKEEESILNYLLEVRSSLAKLKQNRTQYLNS KDVQTTYQHVLTKVRELDDIRKNSHETPAKSAATLIHSTELHNRVDSVLDDVFQLLSL CFLTVGLKNSAPATYASLSTVESLLEHLNESNVFTHHDLSPIKERLEEISKIVEQKNS SPAYDEDGNDDRLREIDNERKKNKIEEDLLLRAKLKHCKDEYDILEGKLEEIDPSLST VMEKLFRIRRGLLSLVASAKKTMSKSDINTNSLLQEQNDLQTNNESLTDDKHLVSQEY VHEKLSVLKNELSELESNRDDSGKFKSLESHQVAEKGQSVLNGLLDDCHDLVNDLSHQ KNGGLTLDPYLQPIYEQLIDIKTTLENLMITRRWTLRETDLFSYQKKLNEIDNKRING KFPTKSQDSKGQSILLYLLRRCYAIIYKLLESSEPVSEALQPIHNQLSTVRRCLLELK RMGGVNNERELYPYQMKLASLDNLRTEGIFYDSDGNIPEGQGILNALLAECFDILHEL KVEAEEKAQNSTSSDGSDDDDNGESGIDSNSNDSEPESEYQQE" gene complement(51244..52671) /gene="APM1" /locus_tag="YPL259C" /gene_synonym="YAP54" mRNA complement(51244..52671) /gene="APM1" /locus_tag="YPL259C" /gene_synonym="YAP54" /product="Apm1p" CDS complement(51244..52671) /gene="APM1" /locus_tag="YPL259C" /gene_synonym="YAP54" /experiment="EXISTENCE:direct assay:GO:0030121 AP-1 adaptor complex [PMID:10564262]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:17003107]" /note="Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex" /codon_start=1 /product="Apm1p" /protein_id="DAA11176.1" /db_xref="SGD:S000006180" /translation="MASAVYFCDHNGKPLLSRRYRDDIPLSAIDKFPILLSDLEEQSN LIPPCLNHNGLEYLFIQHNDLYVVAIVTSLSANAAAIFTFLHKLVEVLSDYLKTVEEE SIRDNFVIIYELLDEVMDYGIPQITETKMLKQYITQKSFKLVKSAKKKRNATRPPVAL TNSVSWRPEGITHKKNEAFLDIVESINMLMTQKGQVLRSEIIGDVKVNSKLSGMPDLK LGINDKGIFSKYLDDDTNIPSASATTSDNNTETDKKPSITSSSATNKKKVNIELEDLK FHQCVRLSKFENEKIITFIPPDGKFDLMNYRLSTTIKPLIWCDVNVQVHSNSRIEIHC KAKAQIKRKSTATNVEILIPVPDDADTPTFKYSHGSLKYVPEKSAILWKIRSFPGGKE YSMSAELGLPSISNNEDGNRTMPKSNAEILKGPVQIKFQIPYFTTSGIQVRYLKINEP KLQYKSYPWVRYITQSGDDYTIRLT" gene 52977..53465 /gene="SUT390" /locus_tag="YNCP0025W" ncRNA 52977..53465 /ncRNA_class="other" /gene="SUT390" /locus_tag="YNCP0025W" /product="SUT390" /note="Stable Unannotated Transcript functional ncRNA; improves endogenous invertase secretion when deleted" /db_xref="SGD:S000345043" gene complement(53498..55153) /gene="THI21" /locus_tag="YPL258C" mRNA complement(53498..55153) /gene="THI21" /locus_tag="YPL258C" /product="bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase" CDS complement(53498..55153) /gene="THI21" /locus_tag="YPL258C" /EC_number="2.7.1.49" /EC_number="2.7.4.7" /experiment="EXISTENCE:direct assay:GO:0008902 hydroxymethylpyrimidine kinase activity [PMID:15614489]" /experiment="EXISTENCE:direct assay:GO:0008972 phosphomethylpyrimidine kinase activity [PMID:15614489]" /experiment="EXISTENCE:genetic interaction:GO:0008902 hydroxymethylpyrimidine kinase activity [PMID:15614489]" /experiment="EXISTENCE:genetic interaction:GO:0008972 phosphomethylpyrimidine kinase activity [PMID:15614489|PMID:10383756]" /experiment="EXISTENCE:genetic interaction:GO:0009228 thiamine biosynthetic process [PMID:10383756]" /note="Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p" /codon_start=1 /product="bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase" /protein_id="DAA11177.1" /db_xref="SGD:S000006179" /translation="MTYSTVNINTPPPYLALASNEKLPTVLSIAGTDPSGGAGVEADV KTITAHRCYAMTCITALNAQTPVKVYSINNTPKEVVSQILDANLQDMKCDVIKTGMLT TAAIEVLHEKLLQLGENRPKLVVDPVLVATSGSSLAGKDIASLITEKIAPFADILTPN IPECFKLLGEDREISKLRDIFEVAKDLAKITKCSNILVKGGHIPWNDEEGKYITDVLY LGAEQRFITFKGNFVNTTHTHGTGCTLASAIASNLARGYSLPQSVYGGIEYVQNAVAI GCDVTKETVKDNGPINHVYAIEIPLEKMLSDECFTASDAVHKKPVKSSLNKIPGGSFY KYLINHPKVKPHWDSYVNHDFVRKVADGSLEPKKFQFFIEQDYLYLVNYARISCIAGS KSPCLEDLEKELVIVECVRNGLCQHERRLREEFGIKDPDYLQKIQRGPALRAYCRYFN DVSRRGNWQELVIALNPCLMGYVHALTKIKDEVTAAEGSVYREWCETYSSSWCHEAML EGEKLLNHILETYPPEKLDTLVTIYAEVCELEANFWTAALEYE" repeat_region complement(55657..55858) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007184" gene complement(56169..56274) /locus_tag="YNCP0001C" tRNA complement(join(56169..56204,56239..56274)) /locus_tag="YNCP0001C" /product="tRNA-Trp" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Tryptophan tRNA (tRNA-Trp), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006776" repeat_region 56290..56358 /note="Ty3 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007198" repeat_region 56409..56451 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007189" mobile_element 56452..62375 /note="YPLWTy1-1; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats" /mobile_element_type="retrotransposon:YPLWTy1-1" /db_xref="SGD:S000007199" repeat_region 56452..56788 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007190" gene 56748..62016 /locus_tag="YPL257W-B" mRNA 56748..62016 /locus_tag="YPL257W-B" /product="gag-pol fusion protein" CDS join(56748..58052,58054..62016) /locus_tag="YPL257W-B" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /codon_start=1 /product="gag-pol fusion protein" /protein_id="DAA11178.1" /db_xref="SGD:S000007358" /translation="MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKTEECE KASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWS FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM TVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNN SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQELTESTVNHTNHS DDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQD NTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWV SKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNE SDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPNS APSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSE YTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFS AIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGI PGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLT ASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTE DSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAP MSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKR IIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPD PFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSL EPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLL KMKTWDTDEYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSGMQS NTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLK KSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDL NANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIP KLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRF DLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISD ASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSY LIQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYY IETKKNIADVMTKPLPIKTFKLLTNKWIH" gene 56748..58070 /locus_tag="YPL257W-A" mRNA 56748..58070 /locus_tag="YPL257W-A" /product="gag protein" CDS 56748..58070 /locus_tag="YPL257W-A" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /codon_start=1 /product="gag protein" /protein_id="DAA11179.1" /db_xref="SGD:S000007357" /translation="MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKTEECE KASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWS FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM TVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNN SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPGTY" repeat_region 62039..62375 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007191" repeat_region 62389..62720 /note="Ty2 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007192" repeat_region 62724..63006 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007193" gene 63279..63860 /locus_tag="YPL257W" mRNA 63279..63860 /locus_tag="YPL257W" /product="hypothetical protein" CDS 63279..63860 /locus_tag="YPL257W" /note="hypothetical protein; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11180.1" /db_xref="SGD:S000006178" /translation="MTAHANERISDVSPSARGSSSESKYDKLCRVLFFIAITKSSFTP EHILYKHSIFTDKPILADIVTFMYAAFVSIGWFLIWGERAYRTQEMGQPPMYSNINYH LLSFKKRHPKKFTCALWLVFFLAYTVLTVLIWLVQLIFRKGNVFQMLLQLIILDIAIA LVNVAIAFTFEIYLSQKAAIEIRDEGLNNLDTA" gene complement(64977..66614) /gene="CLN2" /locus_tag="YPL256C" mRNA complement(64977..66614) /gene="CLN2" /locus_tag="YPL256C" /product="cyclin CLN2" CDS complement(64977..66614) /gene="CLN2" /locus_tag="YPL256C" /experiment="EXISTENCE:direct assay:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:2142620]" /experiment="EXISTENCE:direct assay:GO:0001932 regulation of protein phosphorylation [PMID:8387915|PMID:7862657|PMID:10409718]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11792824|PMID:11080155|PMID:10611233]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10611233|PMID:11509671|PMID:11792824|PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:8387915|PMID:10409718|PMID:7862657]" /experiment="EXISTENCE:genetic interaction:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:9927449]" /experiment="EXISTENCE:genetic interaction:GO:0007089 traversing start control point of mitotic cell cycle [PMID:2574633|PMID:2147225]" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:11509671]" /experiment="EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:2569741]" /note="G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN2 has a paralog, CLN1, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1" /codon_start=1 /product="cyclin CLN2" /protein_id="DAA11181.1" /db_xref="SGD:S000006177" /translation="MASAEPRPRMGLVINAKPDYYPIELSNAELLSHFEMLQEYHQEI STNVIAQSCKFKPNPKLIDQQPEMNPVETRSNIITFLFELSVVTRVTNGIFFHSVRLY DRYCSKRIVLRDQAKLVVATCLWLAAKTWGGCNHIINNVVIPTGGRFYGPNPRARIPR LSELVHYCGDGQVFDESMFLQMERHILDTLNWNIYEPMINDYVLNVDENCLMQYELYE NQVTYDKQCSEKRQSQLSQDSDATVDERPYQNEEEEEEDLKLKIKLINLKKFLIDVSA WQYDLLRYELFEVSHGIFSIINQFTNQDHGPFLMTPMTSESKNGEILSTLMNGIVSIP NSLMEVYKTVNGVLPFINQVKEYHLDLQRKLQIASNLNISRKLTISTPSCSFENSNST SIPSPASSSQSHTPMRNMSSLSDNSVFSRNMEQSSPITPSMYQFGQQQSNSICGSTVS VNSLVNTNNKQRIYEQITGPNSNNATNDYIDLLNLNESNKENQNPATAHYLNGGPPKT SFINHGMFPSPTGTINSGKSSSASSLISFGMGNTQVI" gene 67725..68882 /gene="BBP1" /locus_tag="YPL255W" mRNA 67725..68882 /gene="BBP1" /locus_tag="YPL255W" /product="Bbp1p" CDS 67725..68882 /gene="BBP1" /locus_tag="YPL255W" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:20139001]" /experiment="EXISTENCE:direct assay:GO:0005823 central plaque of spindle pole body [PMID:10654940]" /experiment="EXISTENCE:genetic interaction:GO:0030474 spindle pole body duplication [PMID:10654940]" /experiment="EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:10654940]" /experiment="EXISTENCE:mutant phenotype:GO:0071988 protein localization to spindle pole body [PMID:14767068|PMID:11952896]" /note="Protein required for the spindle pole body (SPB) duplication; localizes at the cytoplasmic side of the central plaque periphery of the SPB; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p" /codon_start=1 /product="Bbp1p" /protein_id="DAA11182.1" /db_xref="SGD:S000006176" /translation="MNQEDNTGGGGIFGLFKWTKDALFGTDISPSMKYKDQEERRDRS RYAQDDTNFSMKFGNDSNRRSTNLSRSNSWSGLDSTLHRKYELLPEYNENGFNSIVNG DHHSKERIRSLRSPAPIVPREPLRNEPTDTFGHRLHTKRRTINELSNSQIPFIPPQED DPLLSKLFNKDGVNEVRRSPYKLSVKDIPGKFPSPLTKRDEIDNYYVRDEDACHKNRE YKKAYFDLFAQMDLNSRDLEDLCEDVREQREQFHRNEQTYKQAYEEMRAELVNELKKS KTLFENYYSLGQKYKSLKKVLDQTISHEAELATSRERLYQEEDLKNFEIQTLKQRLSD LELKYTNLQIEKDMQRDNYESEIHDLLLQLSLRNNERKDTSAGSNIFSTGQ" gene 69485..70951 /gene="HFI1" /locus_tag="YPL254W" /gene_synonym="ADA1" /gene_synonym="GAN1" /gene_synonym="SRM12" /gene_synonym="SUP110" mRNA 69485..70951 /gene="HFI1" /locus_tag="YPL254W" /gene_synonym="ADA1" /gene_synonym="GAN1" /gene_synonym="SRM12" /gene_synonym="SUP110" /product="Hfi1p" CDS 69485..70951 /gene="HFI1" /locus_tag="YPL254W" /gene_synonym="ADA1" /gene_synonym="GAN1" /gene_synonym="SRM12" /gene_synonym="SUP110" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:12446794]" /experiment="EXISTENCE:mutant phenotype:GO:0003712 transcription coregulator activity [PMID:9154821]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:10048020]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:9154821]" /note="Adaptor protein required for structural integrity of the SAGA complex; a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions" /codon_start=1 /product="Hfi1p" /protein_id="DAA11183.1" /db_xref="SGD:S000006175" /translation="MSAIQSPAPKPLQPTYPAASPASTNAYMKPGLIGSPAVSNHTEP NNGNNETAEPQGPNQRIDLGAMIEELTSLLGKESWTKYAQIISLFILGKLSRKELSNE LELVFSPSAASLEKSNTNHHHSLVRLHNQLLLGIFANSLRENPLGRNGNESSWGFGNG SNNPNNKLKRINKHNSQIEVYKKIVMSLPLNDRNRLKMITKEAGKRGFIFCSVFQARL NNIPKIPIVTNPESLKRVKSNNLKTPLEWSQDIMNGFNVPLASESHSLPDTDSFYLRM VGIAREHGLVGTVDARCVELISLALDQYLKNIIEFTIDTVRYRRKKYSDYYDLNESGL YKSVSEMAADKRDAKIKQLDDDKNEDECADEAKSINNGNNSSKDDIGDISMSSITKAG EAVNEELHENRTISLTNEDIYDSLSIFPNLVEPSGSYYALTNLGLVNDDELVDMKSNI DDLPDFLNEKPTFTPLDERNVGTRHELNWLIKGILTED" gene complement(71063..73006) /gene="VIK1" /locus_tag="YPL253C" mRNA complement(71063..73006) /gene="VIK1" /locus_tag="YPL253C" /product="Vik1p" CDS complement(71063..73006) /gene="VIK1" /locus_tag="YPL253C" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:10087265|PMID:11729143]" /experiment="EXISTENCE:direct assay:GO:0005871 kinesin complex [PMID:10087265]" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:22734002]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714]" /experiment="EXISTENCE:mutant phenotype:GO:0007017 microtubule-based process [PMID:10087265]" /experiment="EXISTENCE:mutant phenotype:GO:0007020 microtubule nucleation [PMID:33752231]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714]" /experiment="EXISTENCE:physical interaction:GO:0007017 microtubule-based process [PMID:10087265]" /note="Protein that forms a kinesin-14 heterodimeric motor with Kar3p; localizes Kar3p at mitotic spindle poles; has a structure similar to a kinesin motor domain but lacks an ATP-binding site and is catalytically inactive; binds microtubules; required for sister chromatid cohesion; VIK1 has a paralog, CIK1, that arose from the whole genome duplication" /codon_start=1 /product="Vik1p" /protein_id="DAA11184.1" /db_xref="SGD:S000006174" /translation="MASQQNKHAFLSKNRIFHNPDNVSSSKSRNLMDITNTTNTMNGS RPSSMKSSLALPPVKDSFPSVSRSASLNINMSKIKDLKDRQDKIRFQRHTLRTQLIEC EREIKTIKFRDLNKSRFELYKKKSKQAKYLKQVRDLTQNLNSKDGERADLIKKNKSAL ATLQAELDQNLILKRQESQELYNNKLIFWENELQIMENVEPDHEITEEISQLKKTLQE LNINWANLQKQNLERQVNHESQLRKDFIAFKEAKLKSMENLTNKHRELLDQIATLQSE SEKLHKEIMDIDRQAEYSEQNISEINENIKQLELANNPLISKSLQNSQDLEHLQNQME NLKEMASKQEKFYNDTYNTVEKELLRSRRLENSIIEQKGTMRCYAYVMEQNLPENLLF DYENGVITQGLSEHVYKFNRVIPHLKVSEDKFFTQEYSVYHDMCLNQKKNFNLISLST TPHGSLRESLIKFLAEKDTIYQKQYVITLQFVFLSDDEFSQDMLLDYSHNDKDSIKLK FEKHSISLDSKLVIIENGLEDLPLNFSCDEHPNLPHSGMGIIKVQFFPRDSKSDGNND PVPVDFYFIELNNLKSIEQFDKSIFKKESCETPIALVLKKLISDTKSFFLLNLNDSKN VNKLLTISEEVQTQLCKRKKKLT" rep_origin 73032..73227 /note="ARS1605; Autonomously Replicating Sequence" /db_xref="SGD:S000118412" gene complement(73363..73881) /gene="YAH1" /locus_tag="YPL252C" mRNA complement(73363..73881) /gene="YAH1" /locus_tag="YPL252C" /product="adrenodoxin" CDS complement(73363..73881) /gene="YAH1" /locus_tag="YPL252C" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:10375636]" /experiment="EXISTENCE:genetic interaction:GO:0006784 heme A biosynthetic process [PMID:11788607]" /experiment="EXISTENCE:genetic interaction:GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [PMID:11788607]" /experiment="EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:20534343|PMID:21944752]" /experiment="EXISTENCE:mutant phenotype:GO:0006784 heme A biosynthetic process [PMID:11788607]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:12970193]" /experiment="EXISTENCE:mutant phenotype:GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [PMID:11788607]" /note="Ferredoxin of the mitochondrial matrix; required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; human homolog FDX1L can complement yeast by allowing growth during down-regulation of yeast YAH1" /codon_start=1 /product="adrenodoxin" /protein_id="DAA11185.1" /db_xref="SGD:S000006173" /translation="MLKIVTRAGHTARISNIAAHLLRTSPSLLTRTTTTTRFLPFSTS SFLNHGHLKKPKPGEELKITFILKDGSQKTYEVCEGETILDIAQGHNLDMEGACGGSC ACSTCHVIVDPDYYDALPEPEDDENDMLDLAYGLTETSRLGCQIKMSKDIDGIRVALP QMTRNVNNNDFS" gene complement(74309..74719) /gene="ATG41" /locus_tag="YPL250C" /gene_synonym="ICY2" mRNA complement(74309..74719) /gene="ATG41" /locus_tag="YPL250C" /gene_synonym="ICY2" /product="Atg41p" CDS complement(74309..74719) /gene="ATG41" /locus_tag="YPL250C" /gene_synonym="ICY2" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:26565778]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:26565778]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:26565778]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:26565778]" /note="hypothetical protein; required for selective and nonselective autophagy, and mitophagy; regulates the rate of autophagosome formation; interacts with Atg9p, and has a similar peri-mitochondrial localization; elevated Gcn4p-dependent expression under autophagy-inducing conditions; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate; ATG41 has a paralog, ICY1, that arose from the whole genome duplication" /codon_start=1 /product="Atg41p" /protein_id="DAA11186.1" /db_xref="SGD:S000006171" /translation="MSSVESSPISRYEDEVFPLSFSNVAFEPPMLSHSPDRSTYADDF SQSYQQELLTFPLSYPIVDESECTHTKDKTDSNIITSTEDDCMFDMEFNGNAASAVAA ASKESNSASGFAFASNDAFANVAQQNYRLWLSSV" gene complement(75699..76239) /gene="RPL36B" /locus_tag="YPL249C-A" mRNA complement(join(75699..75985,76224..76239)) /gene="RPL36B" /locus_tag="YPL249C-A" /product="ribosomal 60S subunit protein L36B" CDS complement(join(75699..75985,76224..76239)) /gene="RPL36B" /locus_tag="YPL249C-A" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /note="Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication" /codon_start=1 /product="ribosomal 60S subunit protein L36B" /protein_id="DAA11187.1" /db_xref="SGD:S000006438" /translation="MAVKTGIAIGLNKGKKVTQMTPAPKISYKKGAASNRTKFVRSLV REIAGLSPYERRLIDLIRNSGEKRARKVAKKRLGSFTRAKAKVEEMNNIIAASRRH" gene complement(76669..79353) /gene="GYP5" /locus_tag="YPL249C" mRNA complement(76669..79353) /gene="GYP5" /locus_tag="YPL249C" /product="GTPase-activating protein GYP5" CDS complement(76669..79353) /gene="GYP5" /locus_tag="YPL249C" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:15331637]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005798 Golgi-associated vesicle [PMID:15331637]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12189143|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15331637]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:15331637|PMID:22842922|PMID:32015451]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:22842922|PMID:15331637]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:35134079]" /experiment="EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:15802519|PMID:12189143]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:15802519]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:12189143]" /note="GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog, GYL1, that arose from the whole genome duplication" /codon_start=1 /product="GTPase-activating protein GYP5" /protein_id="DAA11188.1" /db_xref="SGD:S000006170" /translation="MSSDKSIEKNTDTIASEVHEGDNHSNNLGSMEEEIKSTPSDQYE EIAIIPTEPLHSDKELNDKQQSLGHEAPTNVSREEPIGISGDEDTQITEQNVNEQRQE TREPSSEIDLNEPLDVEKDVTTDVQAPNGLNIEKEYDAVKENEKVYADTKEVVSSPEN REVTGKNSGGEKSSSSKFLDDESGTTTAANANDISISSEVTPERSSENDNNQIHITNE VAAGINLNENKEQKAAIEDGPVTAENLSSETARKVPPIPTQIINEKGDNSSENEVSAI PTTSSPPLPPRQNVATSTSPKLPPRGKQREQPPKTKNAVPPPLEEEMKSEKFRKNFEE TKRNSYHHVPLTGSKTAQLESTAEINLIASRYRKTSHHLNKEGEETRESLQEGQSFLK STFTSFLENLSEYNEVENVNEEDREMFKIDWSFWTQVVNDYATVASNEPENLEAHVTN GIPPQIRGIIWQLMANSKSREMEDIYETLLDTECLHEATIRRDLRRTKFVAEDKMESL YKVIKVYSVYDPDVGYTQGMGFIAAPLLINCENEAESFGLLVGLMKNYGLRELFLPGM PGLMLMLYQFDRLLEEHSPSLYNRLIREGISSTMYATQWFLTFFAYKFPLEFVLRIFD IVFVEGIEVLLKFAVNLMLKNEETLVKLRFDELLDFLKDELFNYYLMGNQDDASVVQM GLSNGNSFKGNDDGTFSYNVDLFVHDAMTGVYITPLTLRRYRGEYVEIHEKEQKKEDH YESLRIQNHQLQREAQKLEHDYSILNKENISAANELIQNRLNMEMLLDEKNDLINTIT DIKSQIEEEIRKQNLPNPDASLPKADLREDLERTISRNNEVMRENGQLEERITELQAE IDELININKEQVSTASLLERDSKAKGRKGWTGFKKVFK" gene 79562..82648 /locus_tag="YNCP0002W" ncRNA 79562..82648 /ncRNA_class="antisense_RNA" /locus_tag="YNCP0002W" /product="GAL4 lncRNA" /note="Antisense to GAL4/YPL248C; influences expression of GAL4 mRNA" /db_xref="SGD:S000303815" gene complement(79711..82356) /gene="GAL4" /locus_tag="YPL248C" /gene_synonym="GAL81" mRNA complement(79711..82356) /gene="GAL4" /locus_tag="YPL248C" /gene_synonym="GAL81" /product="galactose-responsive transcription factor GAL4" CDS complement(79711..82356) /gene="GAL4" /locus_tag="YPL248C" /gene_synonym="GAL81" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:3886158]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:3080805]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:6091123]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:3886158]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:14871930]" /experiment="EXISTENCE:genetic interaction:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:14871930]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:14871930]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:3080805]" /experiment="EXISTENCE:mutant phenotype:GO:0006012 galactose metabolic process [PMID:6350827]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:6350827]" /experiment="EXISTENCE:physical interaction:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:14871930]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:14871930]" /note="DNA-binding transcription factor required for activating GAL genes; responds to galactose; repressed by Gal80p and activated by Gal3p" /codon_start=1 /product="galactose-responsive transcription factor GAL4" /protein_id="DAA11189.1" /db_xref="SGD:S000006169" /translation="MKLLSSIEQACDICRLKKLKCSKEKPKCAKCLKNNWECRYSPKT KRSPLTRAHLTEVESRLERLEQLFLLIFPREDLDMILKMDSLQDIKALLTGLFVQDNV NKDAVTDRLASVETDMPLTLRQHRISATSSSEESSNKGQRQLTVSIDSAAHHDNSTIP LDFMPRDALHGFDWSEEDDMSDGLPFLKTDPNNNGFFGDGSLLCILRSIGFKPENYTN SNVNRLPTMITDRYTLASRSTTSRLLQSYLNNFHPYCPIVHSPTLMMLYNNQIEIASK DQWQILFNCILAIGAWCIEGESTDIDVFYYQNAKSHLTSKVFESGSIILVTALHLLSR YTQWRQKTNTSYNFHSFSIRMAISLGLNRDLPSSFSDSSILEQRRRIWWSVYSWEIQL SLLYGRSIQLSQNTISFPSSVDDVQRTTTGPTIYHGIIETARLLQVFTKIYELDKTVT AEKSPICAKKCLMICNEIEEVSRQAPKFLQMDISTTALTNLLKEHPWLSFTRFELKWK QLSLIIYVLRDFFTNFTQKKSQLEQDQNDHQSYEVKRCSIMLSDAAQRTVMSVSSYMD NHNVTPYFAWNCSYYLFNAVLVPIKTLLSNSKSNAENNETAQLLQQINTVLMLLKKLA TFKIQTCEKYIQVLEEVCAPFLLSQCAIPLPHISYNNSNGSAIKNIVGSATIAQYPTL PEENVNNISVKYVSPGSVGPSPVPLKSGASFSDLVKLLSNRPPSRNSPVTIPRSTPSH RSVTPFLGQQQQLQSLVPLTPSALFGGANFNQSGNIADSSLSFTFTNSSNGPNLITTQ TNSQALSQPIASSNVHDNFMNNEITASKIDDGNNSKPLSPGWTDQTAYNAFGITTGMF NTTTMDDVYNYLFDDEDTPPNPKKE" gene complement(82625..84196) /locus_tag="YPL247C" mRNA complement(82625..84196) /locus_tag="YPL247C" /product="hypothetical protein" CDS complement(82625..84196) /locus_tag="YPL247C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11190.1" /db_xref="SGD:S000006168" /translation="MDPFHNGNKRSSISFGSSQRQPYNKNNYLSGTNGPSSAAQDQGR GPSPFGMSGNTTNGGNSKRNSGCDLSATYYASRSPMYSPLDFSPPVFSPNHSQLQQAR GYAANIPVVSNLMNPSMASVCEYQSHYPLFGLDWSADDYVCLGSYKEDSRNKLQVLHS NDLLSWESVVDADVVYPVSKIQWVPSQLYPRKLATCSDSLRIWSVSPEERQFQEQINL SLCKYNRQHPANPAAADDMKVIGTFPPITSFDWNTVDTNLIISSSIDTTCIVWDLQSS HYVKTQLIAHDSEVFDVRFLTKSTQLFASCGGDGSVRVFDLRSLAHSTIIYEPPSSSV SGATAGTITPSSKGSDALLRLEPSPYDPNVLATFAADSNKIIILDMRNPESPILNLQG HGSSVNGIKWHPTKRNVLLSCGDDCQVLYWDLNSSFMEINAAGSKSPSIHGTSLEDPD GDTEMTDGGAGSGLNEDPLSLNNNSKQVCKTLETPNMMYANKTQEINNIAWRPQRGDW FGCVSGKKFQNVRVL" gene complement(84509..85297) /gene="RBD2" /locus_tag="YPL246C" mRNA complement(84509..85297) /gene="RBD2" /locus_tag="YPL246C" /product="putative rhomboid protease RBD2" CDS complement(84509..85297) /gene="RBD2" /locus_tag="YPL246C" /EC_number="3.4.21.105" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /note="Possible rhomboid protease; has similarity to eukaryotic rhomboid proteases including Pcp1p" /codon_start=1 /product="putative rhomboid protease RBD2" /protein_id="DAA11191.1" /db_xref="SGD:S000006167" /translation="MNWKSYVFPGGHPPAALTTGLVVFLTAIYLLSFIFALREDLSLA PESLFKLQMSRLSLYPLIHLSLPHLLFNVLAIWAPLNLFEETHGTVYTGVFLNLSALF AGILYCLLGKLLYPEALVAGASGWCFTLFAYYSFKESQIRPRTRIFRTDYSIPTLYTP LVLLVAIAVVIPGSSFWGHFFGLCVGYAIGYKESWFNKITPPGWIITKIEKSLDGLIR LIPWGIKYYRDEDIDRTKDYEPLMSTETPLPLHNDNSGTVLGTA" gene 85586..86950 /locus_tag="YPL245W" mRNA 85586..86950 /locus_tag="YPL245W" /product="hypothetical protein" CDS 85586..86950 /locus_tag="YPL245W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11192.1" /db_xref="SGD:S000006166" /translation="MHGPTSKAISRNVRSVKRPRRAPRPVVSTQAMNKLSNVTLSAEQ EKLRERVLSFMRSNLSQYKSDWKHPAMFVIQGDAGTGKSVILNSLFNEIQKLSQFSPS SEDILHGTHNYLVVNHPEMLKLYIRISDSFKYISKSSLERPTSLINNLQKRKVMADVV IVDEAHLLATSKDAFKRFYGENHLKDLMSLCKVLVLVYDDKQALRMGSYWDEGSNNGA TLKDFYNEIPPKSRDWYTLKQQFRVAAPQNVLNWIDQISVAGKIPPIESVLSKGNADC ADDKIKNFDFKIWDDCGAMYEAIKEKDRQYGQCRMLSTYDFPYRLDGKDYYVECGDNF KVRWDRYTPREVTPWSERCDTIDEVGSVYTIQGFDLNYAGVILGRSIGYDAANDCIKL RPELYDDRAGFTKKKNIHNAEDVKQKIIMNSINVLLTRGVRGLYVYAYDPELRERLLR PSKK" gene complement(87014..88033) /gene="HUT1" /locus_tag="YPL244C" mRNA complement(87014..88033) /gene="HUT1" /locus_tag="YPL244C" /product="UDP-galactose transporter HUT1" CDS complement(87014..88033) /gene="HUT1" /locus_tag="YPL244C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015786 UDP-glucose transmembrane transport [PMID:18693752]" /experiment="EXISTENCE:mutant phenotype:GO:0015786 UDP-glucose transmembrane transport [PMID:18693752]" /experiment="EXISTENCE:mutant phenotype:GO:0072334 UDP-galactose transmembrane transport [PMID:11284009]" /note="Protein with a role in UDP-galactose transport to the Golgi lumen; has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1" /codon_start=1 /product="UDP-galactose transporter HUT1" /protein_id="DAA11193.1" /db_xref="SGD:S000006165" /translation="MAGSTSSLVICAIGIYATFLTWALVQEPLATRTWPNSMGKFQFP NVISLIQASVAMMMGYLYLNWKKVEYPPRKMIKDHWKQLMLISFTQSSSGPLATTSLK HVDYLTYMLAKSCKMIPVLLVHLLLYRTPIASQKKVVALLVSLGVTIFTIGGNDGKKL KRSFNESGNDNKLQGFGLLFSSLFLDGLTNATQDKLLKANKAKEKGKQTLITGAHLMF TLNLFVILWNILYFIVIDCKQWDNAVSVLTMDPQVWGYLMLYSFCGAMGQCFIFYTLE QFGSLVLIMITVTRKMVSMILSIIVFGKSVRFQQWVGMFIVFGGITWEALNKKKANIP KAKSA" gene 88517..90316 /gene="SRP68" /locus_tag="YPL243W" mRNA 88517..90316 /gene="SRP68" /locus_tag="YPL243W" /product="signal recognition particle subunit SRP68" CDS 88517..90316 /gene="SRP68" /locus_tag="YPL243W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005786 signal recognition particle, endoplasmic reticulum targeting [PMID:7925282]" /experiment="EXISTENCE:direct assay:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:10921896]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:22842922]" /note="Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress" /codon_start=1 /product="signal recognition particle subunit SRP68" /protein_id="DAA11194.1" /db_xref="SGD:S000006164" /translation="MVAYSPIIATYGNRAEQFLETDSDFAKYHAKLNKKLQHLRSRCH LVTKDTKKYSSKNKYGEINSEDYDNKTKLIGVLILLHAERDLALAETLKLRARQRGKL KKSEEKVLSTRLKKACKTADKLVNVTQNEQQWITRAQYLAFAKLVHSEYLINGKRFKR KDNAKISNNLALVFAALEHLKNLSLLAEEVVDNIVNKYQYSLKQYAGNLITTPEINNF IVERVQSDENKDDELVKLLLDNGFNMKKITTSTEDQKVTTNINWRSFNAKIIDAEVAQ FLEQGLSIHPTQITQYTQRLSKLEKALDRHEFFIANHDDQDDIDEMVENSSENNQIIL AYIKYNILLTSISRERDLFTHLWNQWLKLNTSLPSKLTKYKEMERIVKNLTKYLSDIM ELPGVYSDDELLSQLDLCKLYFQLFLNTGCLSVLYQSKGRYMEALALYVDAYRRLENK LSEIESLDEILLPANLLSLNSVRSLQKRIENGGNSVITLAEYEKRNHGGSLGKYDLTV IEKLDSKKILPTDIQLKNLFPLKPKMLPIPSKPTLFDLAFNYITYDKQEPSASQVKDS VTETESISQTPISNEQTEGEPKKKRGFLGLFGR" gene complement(90622..95109) /gene="IQG1" /locus_tag="YPL242C" /gene_synonym="CYK1" mRNA complement(90622..95109) /gene="IQG1" /locus_tag="YPL242C" /gene_synonym="CYK1" /product="Iqg1p" CDS complement(90622..95109) /gene="IQG1" /locus_tag="YPL242C" /gene_synonym="CYK1" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:10873803|PMID:9950677|PMID:9442111|PMID:9382845]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11082046|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:9950677|PMID:9382845]" /experiment="EXISTENCE:direct assay:GO:0120155 MIH complex [PMID:24895401]" /experiment="EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:21173112]" /experiment="EXISTENCE:mutant phenotype:GO:0051015 actin filament binding [PMID:9382845|PMID:9950677]" /experiment="EXISTENCE:mutant phenotype:GO:0072741 protein localization to cell division site [PMID:21173112]" /experiment="EXISTENCE:mutant phenotype:GO:1903471 regulation of mitotic actomyosin contractile ring contraction [PMID:24895401|PMID:26085509|PMID:9950677|PMID:19109423]" /experiment="EXISTENCE:mutant phenotype:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:21173112|PMID:11082046]" /experiment="EXISTENCE:mutant phenotype:GO:1903479 mitotic actomyosin contractile ring assembly actin filament organization [PMID:9442111|PMID:9950677|PMID:9382845]" /experiment="EXISTENCE:physical interaction:GO:0005516 calmodulin binding [PMID:9950677]" /experiment="EXISTENCE:physical interaction:GO:0032027 myosin light chain binding [PMID:10873803]" /experiment="EXISTENCE:physical interaction:GO:0032033 myosin II light chain binding [PMID:11082046]" /experiment="EXISTENCE:physical interaction:GO:0032038 myosin II heavy chain binding [PMID:11082046]" /experiment="EXISTENCE:physical interaction:GO:0120155 MIH complex [PMID:24895401]" /note="Actin filament binding protein that enhances actin ring formation; IQGAP family member required for assembly and contraction of the AMR, prior to cytokinesis; localizes to the contractile ring during anaphase in an Mlc1p-dependent manner, recruiting Myo1p and Hof1p to the site, and promoting cytokinetic core complex assembly; specifies bud-site selection, localizing axial markers Bud4p and Cdc12p; regulated by Cdc28p; relocalizes from the bud neck to the cytoplasm upon replication stress" /codon_start=1 /product="Iqg1p" /protein_id="DAA11195.1" /db_xref="SGD:S000006163" /translation="MTAYSGSPSKPGNNNSYLNRYVENLGTNVTPPLRPQSSSKINSS LNIASPSHLKTKTSASNSSATILSKKVESSVSKLKPSLPNKLVGKYTVDLSNYSKIEL RYYEFLCRVSEVKIWIEAVIEEALPSEIELCVGDSLRNGVFLAKLTQRINPDLTTVIF PAGDKLQFKHTQNINAFFGLVEHVGVPDSFRFELQDLYNKKNIPQVFETLHILISMIN KKWPGKTPALTNVSGQISFTKEEIAACKKAWPRIRDFKSLGTNINTAPASPEEPKEKR SGLIKDFNKFERPNIPVEEILITPRKNITDANCSDFSNTPSPYNEAPKMSNLDVVVEK RKFTPIEPSLLGPTPSLEYSPIKNKSLSYYSPTISKYLTYDTEFYTRRSRAREEDLNY YQTFKYSPSHYSPMRRERMTEEQFLEKVVQLQNICRGVNTRFNLYIQKRLLNLFEQDI LRFQACLRGNKFRVLSSMYLPIRRAKIDVPHVEAIQSRIKGSRIRYKYDKLKFTLSRF SCTVELLQAYCRSKLLKTTVNTKLNDIEISHYPLTKLQSYMRASYVRKKVMSLNTKLN DERESIMKFSAIIRGNVVRCSEDAILSAVHDVHKENISKLQSLIRGIFTRSCLASIIY SLGKENCNIIQLSACIRGNAVRHKVQSLFAPENNLSETVHDLQGLVRGILVRYTLDLV DDIVEYNNLALFQAFSRGALVRESLDQKSSFYKRNVRSVIMIQSWIRKSLQRSAYLEL LDCPNPSLWAVKKFVHLLNGTATIEEVQNQLESCQASLDSENMKKERLLKSIRQQLNI NGVLDKFGLLKDKDHELGISDSTIPKSKYQKYEKLFYMLQVDPSYWKLLYLKEPEFVA KNVYMTFGTVNQRMNDRERSYFTRFVCEMLQNAINEAPSIESFLDNRSQFWQTILQDF LRRESPEFFSIIVPVLDYLSDPVVDFESDPYKIYQEIHGFSSPQHCSPVDDASTKNKF IDNLRCLWHAIEMVAEIYTRKVHTIPVEIRYLCTKIFCYAADKNIEEIDSLRAISSIL VNVFVSEYLVNREYYGYKDSNVQKNNQKIDILMKSLATVFEIKNFDGFLDPLNQYANE IKPHIKDVLYNVLVDPEYEQEGDRLIYLDMVSPSPKLELLTEKVLEISGKFEEYLNEF PEADILHDILEKNLDNSSFPRSGRVTLELDASAYRFLVSDDKMRKIYDQVKRAFVYMM QIEDVDTNLYDLSISTILPQDEPNFANFLEQNPKIRDDPMIQKLKPLKYFTLKNVTLK KIHELESTGTFCSSDNKLQNFLNDIANTIKNPNYAIDYVTQEIYITKETLTKISEMNH SLDIELSRLKKHVDHTIKDFQKAKDFSPVHKSKFGNFKNAVKKVQGRERSELQGMKFK WNTKQLYERGVLKTIRGEKLAELTVKVFGSSGPKFPDIIFKISTSDGSRFGIQMIDKR KGPDKRYSDDVDSFSFKDLIKTQVEPKIETWKLFHSNVVVNNSQLLHLIVSFFYKRNA L" gene complement(95372..96258) /gene="CIN2" /locus_tag="YPL241C" mRNA complement(join(95372..96153,96234..96258)) /gene="CIN2" /locus_tag="YPL241C" /product="GTPase-activating protein CIN2" CDS complement(join(95372..96153,96234..96258)) /gene="CIN2" /locus_tag="YPL241C" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:18376416]" /experiment="EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:2407611]" /experiment="EXISTENCE:genetic interaction:GO:0007021 tubulin complex assembly [PMID:9215891]" /experiment="EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:9215891]" /note="GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; human homolog RP2 complements yeast null mutant" /codon_start=1 /product="GTPase-activating protein CIN2" /protein_id="DAA11196.1" /db_xref="SGD:S000006162" /translation="MDFTAKIKELERELSETSDYKTLQKKTISLRSELNTLSHSLTSY EKEHFSNDIENVLKSINAKLSESKGKKRLFSFKQKNSSSAVHKNVERTELANAPAYTT TLKKHYVLEKGDSAFENLEFCTVTSTTDYSGNSALSGSLCFRNITKCVINLQRIFFQT GSIFITDCTDSIIFLRSPSDKDFQIRLRDLKNCKILIEKLSPSIDCKQVVIIENCHKC IFNASTRDHLIIQDFSNPFQSEETEDNSAFAFEDFDICNKDTMQLFRAYL" gene complement(96496..98625) /gene="HSP82" /locus_tag="YPL240C" /gene_synonym="HSP90" mRNA complement(96496..98625) /gene="HSP82" /locus_tag="YPL240C" /gene_synonym="HSP90" /product="Hsp90 family chaperone HSP82" CDS complement(96496..98625) /gene="HSP82" /locus_tag="YPL240C" /gene_synonym="HSP90" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:32920053]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:27385335|PMID:32920053|PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006458 'de novo' protein folding [PMID:10564510]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12235160]" /experiment="EXISTENCE:direct assay:GO:0032212 positive regulation of telomere maintenance via telomerase [PMID:17954556]" /experiment="EXISTENCE:direct assay:GO:0043248 proteasome assembly [PMID:12853471]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:10564510]" /experiment="EXISTENCE:mutant phenotype:GO:0000492 box C/D snoRNP assembly [PMID:18268103]" /experiment="EXISTENCE:mutant phenotype:GO:0006458 'de novo' protein folding [PMID:9371781]" /experiment="EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:16487343]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:27068472]" /experiment="EXISTENCE:mutant phenotype:GO:0032212 positive regulation of telomere maintenance via telomerase [PMID:17954556]" /experiment="EXISTENCE:mutant phenotype:GO:0042026 protein refolding [PMID:9371781]" /experiment="EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:12853471]" /experiment="EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:27068472]" /experiment="EXISTENCE:physical interaction:GO:0006626 protein targeting to mitochondrion [PMID:12526792]" /note="Hsp90 chaperone; functionally redundant with Hsc82p; required for pheromone signaling; negative regulator of the Hsf1p-dependent heat shock response with Cpr7p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; promotes solubility of chaperone-substrate complexes; DNA damage induced nuclear import is Aha1p dependent; protein abundance increases in response to DNA replication stress; human homolog, HSP90AB1, complements null mutant" /codon_start=1 /product="Hsp90 family chaperone HSP82" /protein_id="DAA11197.1" /db_xref="SGD:S000006161" /translation="MASETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDK IRYKSLSDPKQLETEPDLFIRITPKPEQKVLEIRDSGIGMTKAELINNLGTIAKSGTK AFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKSNDDEQYIWESNAGGSFTVTL DEVNERIGRGTILRLFLKDDQLEYLEEKRIKEVIKRHSEFVAYPIQLVVTKEVEKEVP IPEEEKKDEEKKDEEKKDEDDKKPKLEEVDEEEEKKPKTKKVKEEVQEIEELNKTKPL WTRNPSDITQEEYNAFYKSISNDWEDPLYVKHFSVEGQLEFRAILFIPKRAPFDLFES KKKKNNIKLYVRRVFITDEAEDLIPEWLSFVKGVVDSEDLPLNLSREMLQQNKIMKVI RKNIVKKLIEAFNEIAEDSEQFEKFYSAFSKNIKLGVHEDTQNRAALAKLLRYNSTKS VDELTSLTDYVTRMPEHQKNIYYITGESLKAVEKSPFLDALKAKNFEVLFLTDPIDEY AFTQLKEFEGKTLVDITKDFELEETDEEKAEREKEIKEYEPLTKALKEILGDQVEKVV VSYKLLDAPAAIRTGQFGWSANMERIMKAQALRDSSMSSYMSSKKTFEISPKSPIIKE LKKRVDEGGAQDKTVKDLTKLLYETALLTSGFSLDEPTSFASRINRLISLGLNIDEDE ETETAPEASTAAPVEEVPADTEMEEVD" gene 99484..100086 /gene="YAR1" /locus_tag="YPL239W" mRNA 99484..100086 /gene="YAR1" /locus_tag="YPL239W" /product="Yar1p" CDS 99484..100086 /gene="YAR1" /locus_tag="YPL239W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22570489]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:26112308]" /experiment="EXISTENCE:genetic interaction:GO:0000056 ribosomal small subunit export from nucleus [PMID:22570489]" /experiment="EXISTENCE:genetic interaction:GO:0005634 nucleus [PMID:22570489]" /experiment="EXISTENCE:genetic interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:15611164]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:22570489]" /experiment="EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:15611164]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:22570489]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:15611164]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:15611164]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:22570489]" /experiment="EXISTENCE:physical interaction:GO:0032880 regulation of protein localization [PMID:22570489]" /note="Nucleocytoplasmic shuttling assembly chaperone; co-translationally associates with nascent Rps3p in the cytoplasm and delivers it to pre-ribosomal subunits in the nucleus; required for 40S ribosomal subunit nuclear export, biogenesis and adaptation to osmotic and oxidative stress; contains ankyrin-repeats; expression repressed by heat shock" /codon_start=1 /product="Yar1p" /protein_id="DAA11198.1" /db_xref="SGD:S000006160" /translation="MGLHSEPLDQEDQDTIILDARAGDLDSLKDIFTTLVSPELLSTC KESESDSTALHMAAANGHIETVRYILETVSRANSAEDLKAFVNEVNKTGNTALHWASL NGKLDVVKLLCDEYEADPFIRNKFGHDAIFEAENSGKEEVETYFLKKYDVEPEDDEED TQTEGKNSVQITKGTEIEQVTKEATEALREETEKLNINKD" gene 100496..101353 /gene="SUI3" /locus_tag="YPL237W" mRNA 100496..101353 /gene="SUI3" /locus_tag="YPL237W" /product="translation initiation factor eIF2 subunit beta" CDS 100496..101353 /gene="SUI3" /locus_tag="YPL237W" /experiment="EXISTENCE:direct assay:GO:0001731 formation of translation preinitiation complex [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:9858542]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:16246727|PMID:14698289]" /experiment="EXISTENCE:direct assay:GO:0005850 eukaryotic translation initiation factor 2 complex [PMID:12137565]" /experiment="EXISTENCE:direct assay:GO:0016282 eukaryotic 43S preinitiation complex [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0031369 translation initiation factor binding [PMID:15145951|PMID:22683627|PMID:9395514]" /experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF complex [PMID:11018020|PMID:15838098]" /experiment="EXISTENCE:direct assay:GO:1990856 methionyl-initiator methionine tRNA binding [PMID:16565414]" /experiment="EXISTENCE:mutant phenotype:GO:0001731 formation of translation preinitiation complex [PMID:16449648]" /experiment="EXISTENCE:mutant phenotype:GO:0003743 translation initiation factor activity [PMID:12137565]" /experiment="EXISTENCE:mutant phenotype:GO:0005850 eukaryotic translation initiation factor 2 complex [PMID:12137565]" /experiment="EXISTENCE:physical interaction:GO:0031369 translation initiation factor binding [PMID:22683627|PMID:15145951|PMID:9395514]" /note="Beta subunit of the translation initiation factor eIF2; involved in the identification of the start codon; proposed to be involved in mRNA binding" /codon_start=1 /product="translation initiation factor eIF2 subunit beta" /protein_id="DAA11199.1" /db_xref="SGD:S000006158" /translation="MSSDLAAELGFDPALKKKKKTKKVIPDDFDAAVNGKENGSGDDL FAGLKKKKKKSKSVSADAEAEKEPTDDIAEALGELSLKKKKKKTKDSSVDAFEKELAK AGLDNVDAESKEGTPSANSSIQQEVGLPYSELLSRFFNILRTNNPELAGDRSGPKFRI PPPVCLRDGKKTIFSNIQDIAEKLHRSPEHLIQYLFAELGTSGSVDGQKRLVIKGKFQ SKQMENVLRRYILEYVTCKTCKSINTELKREQSNRLFFMVCKSCGSTRSVSSIKTGFQ ATVGKRRRM" gene complement(101608..102702) /gene="ENV7" /locus_tag="YPL236C" mRNA complement(101608..102702) /gene="ENV7" /locus_tag="YPL236C" /product="putative serine/threonine protein kinase ENV7" CDS complement(101608..102702) /gene="ENV7" /locus_tag="YPL236C" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006624 vacuolar protein processing [PMID:21912603]" /experiment="EXISTENCE:mutant phenotype:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:24610781]" /note="Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; targeted to vacuole via AP-3 pathway; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)" /codon_start=1 /product="putative serine/threonine protein kinase ENV7" /protein_id="DAA11200.1" /db_xref="SGD:S000006157" /translation="MISIVLELFQNLCCCRGFSDATIRVNDKRYRIQRLLGEGGMSFV YLVQLSKNSLIIDNGIATPELYALKKIICPSVESISNGMREIENYKRFQSPYVIKSID SQVMQEKDGSKTIYIVLPYYSLGSLQDSINRRLLEGTFVSEAECVRIMLGVTRGLLCL HDPASRQDNATSRVNVDAVSMTYSDETAMLLEDTPLEMDMLSSNSAGSIAYAHRDITP SNILFSSDGLPVIGDLGSCSQADITIENRHQLSELQEWVNDNCTLPYTPPELLNLKLN QVLSSKVDIWSLGCTFYTLMFGISPFEREEQIHGASLTYAINTGKYSFPRNSRFSEGL LSVIKKCIQVDPIQRPTTSQLLNLLQDLDT" gene 103232..104647 /gene="RVB2" /locus_tag="YPL235W" /gene_synonym="TIH2" /gene_synonym="TIP48" /gene_synonym="TIP49B" mRNA 103232..104647 /gene="RVB2" /locus_tag="YPL235W" /gene_synonym="TIH2" /gene_synonym="TIP48" /gene_synonym="TIP49B" /product="RuvB family ATP-dependent DNA helicase reptin" CDS 103232..104647 /gene="RVB2" /locus_tag="YPL235W" /gene_synonym="TIH2" /gene_synonym="TIP48" /gene_synonym="TIP49B" /EC_number="3.6.4.12" /experiment="EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:16299513]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11604509]" /experiment="EXISTENCE:direct assay:GO:0043138 3'-5' DNA helicase activity [PMID:10952318|PMID:20553504]" /experiment="EXISTENCE:direct assay:GO:0043139 5'-3' DNA helicase activity [PMID:18234224]" /experiment="EXISTENCE:direct assay:GO:0097255 R2TP complex [PMID:15766533]" /experiment="EXISTENCE:direct assay:GO:0110078 TTT Hsp90 cochaperone complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0000492 box C/D snoRNP assembly [PMID:18268103|PMID:11604509]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11278922]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:11604509]" /experiment="EXISTENCE:physical interaction:GO:0000812 Swr1 complex [PMID:14690608|PMID:14645854]" /experiment="EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:14690608]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245|PMID:10952318]" /experiment="EXISTENCE:physical interaction:GO:0097255 R2TP complex [PMID:18268103]" /note="ATP-dependent DNA helicase, also known as reptin; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, the R2TP complex (Rvb1-Rvb2-Tah1-Pih1) and the TTT Hsp90 cochaperone complex that is involved in chromatin remodeling and telomeric chromatin regulation; involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly; member of the AAA+ and RuvB protein families, similar to Rvb1p" /codon_start=1 /product="RuvB family ATP-dependent DNA helicase reptin" /protein_id="DAA11201.1" /db_xref="SGD:S000006156" /translation="MSIQTSDPNETSDLKSLSLIAAHSHITGLGLDENLQPRPTSEGM VGQLQARRAAGVILKMVQNGTIAGRAVLVAGPPSTGKTALAMGVSQSLGKDVPFTAIA GSEIFSLELSKTEALTQAFRKSIGIKIKEETELIEGEVVEIQIDRSITGGHKQGKLTI KTTDMETIYELGNKMIDGLTKEKVLAGDVISIDKASGKITKLGRSFARSRDYDAMGAD TRFVQCPEGELQKRKTVVHTVSLHEIDVINSRTQGFLALFTGDTGEIRSEVRDQINTK VAEWKEEGKAEIVPGVLFIDEVHMLDIECFSFINRALEDEFAPIVMMATNRGVSKTRG TNYKSPHGLPLDLLDRSIIITTKSYNEQEIKTILSIRAQEEEVELSSDALDLLTKTGV ETSLRYSSNLISVAQQIAMKRKNNTVEVEDVKRAYLLFLDSARSVKYVQENESQYIDD QGNVQISIAKSADPDAMDTTE" gene complement(104946..105440) /gene="VMA11" /locus_tag="YPL234C" /gene_synonym="CLS9" /gene_synonym="TFP3" mRNA complement(104946..105440) /gene="VMA11" /locus_tag="YPL234C" /gene_synonym="CLS9" /gene_synonym="TFP3" /product="H(+)-transporting V0 sector ATPase subunit c'" CDS complement(104946..105440) /gene="VMA11" /locus_tag="YPL234C" /gene_synonym="CLS9" /gene_synonym="TFP3" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:11853670]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:15252052]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Vacuolar ATPase V0 domain subunit c'; involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen" /codon_start=1 /product="H(+)-transporting V0 sector ATPase subunit c'" /protein_id="DAA11202.1" /db_xref="SGD:S000006155" /translation="MSTQLASNIYAPLYAPFFGFAGCAAAMVLSCLGAAIGTAKSGIG IAGIGTFKPELIMKSLIPVVMSGILAIYGLVVAVLIAGNLSPTEDYTLFNGFMHLSCG LCVGFACLSSGYAIGMVGDVGVRKYMHQPRLFVGIVLILIFSEVLGLYGMIVALILNT RGSE" gene 106172..106822 /gene="NSL1" /locus_tag="YPL233W" mRNA 106172..106822 /gene="NSL1" /locus_tag="YPL233W" /product="MIND complex subunit NSL1" CDS 106172..106822 /gene="NSL1" /locus_tag="YPL233W" /experiment="EXISTENCE:direct assay:GO:0000444 MIS12/MIND type complex [PMID:14633972]" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:14657030]" /experiment="EXISTENCE:direct assay:GO:0000922 spindle pole [PMID:12455957]" /experiment="EXISTENCE:direct assay:GO:0007059 chromosome segregation [PMID:12455957]" /note="Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p (MIND)" /codon_start=1 /product="MIND complex subunit NSL1" /protein_id="DAA11203.1" /db_xref="SGD:S000006154" /translation="MSQGQSKKLDVTVEQLRSIYHQFHDILEEKTDLHLPKKEYDDDA VRREVQIQLQEFLLSAMTMASKSLEVVNADTVGKTVKQLIMESQEKYMEPFDLDLNEQ VRKMYQEWEDETVKVAQLRQTGPAKINEVYNNSKDEYLAQLDGRIGVLQARMMQQQSA DHDDSTDDADDHINWEHIKQDYVASLNELYQTQQDLPKVRYNVEKVKRLMDFLEED" gene 107275..108147 /gene="SSO1" /locus_tag="YPL232W" mRNA 107275..108147 /gene="SSO1" /locus_tag="YPL232W" /product="syntaxin" CDS 107275..108147 /gene="SSO1" /locus_tag="YPL232W" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19502581]" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:16339720]" /experiment="EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:19502581]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:19502581|PMID:17298976]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19502581|PMID:17298976|PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11001046]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:9195974]" /experiment="EXISTENCE:direct assay:GO:0043325 phosphatidylinositol-3,4-bisphosphate binding [PMID:19502581]" /experiment="EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:19502581]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:19502581]" /experiment="EXISTENCE:genetic interaction:GO:0031321 ascospore-type prospore assembly [PMID:19502581]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11839791]" /experiment="EXISTENCE:mutant phenotype:GO:0031321 ascospore-type prospore assembly [PMID:19502581|PMID:16554438]" /experiment="EXISTENCE:physical interaction:GO:0005484 SNAP receptor activity [PMID:10924463|PMID:7954793]" /note="Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p; SSO1 has a paralog, SSO2, that arose from the whole genome duplication" /codon_start=1 /product="syntaxin" /protein_id="DAA11204.1" /db_xref="SGD:S000006153" /translation="MSYNNPYQLETPFEESYELDEGSSAIGAEGHDFVGFMNKISQIN RDLDKYDHTINQVDSLHKRLLTEVNEEQASHLRHSLDNFVAQATDLQFKLKNEIKSAQ RDGIHDTNKQAQAENSRQRFLKLIQDYRIVDSNYKEENKEQAKRQYMIIQPEATEDEV EAAISDVGGQQIFSQALLNANRRGEAKTALAEVQARHQELLKLEKSMAELTQLFNDME ELVIEQQENVDVIDKNVEDAQLDVEQGVGHTDKAVKSARKARKNKIRCWLIVFAIIVV VVVVVVVPAVVKTR" gene 108652..114315 /gene="FAS2" /locus_tag="YPL231W" mRNA 108652..114315 /gene="FAS2" /locus_tag="YPL231W" /product="trifunctional fatty acid synthase subunit FAS2" CDS 108652..114315 /gene="FAS2" /locus_tag="YPL231W" /EC_number="1.1.1.100" /EC_number="2.3.1.41" /EC_number="2.3.1.86" /experiment="EXISTENCE:direct assay:GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [PMID:365179]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:6025308|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005835 fatty acid synthase complex [PMID:65153]" /experiment="EXISTENCE:mutant phenotype:GO:0004312 fatty acid synthase activity [PMID:65153]" /experiment="EXISTENCE:mutant phenotype:GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity [PMID:1100391]" /experiment="EXISTENCE:mutant phenotype:GO:0008897 holo-[acyl-carrier-protein] synthase activity [PMID:10785388]" /experiment="EXISTENCE:mutant phenotype:GO:0042759 long-chain fatty acid biosynthetic process [PMID:1735446]" /note="Alpha subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities" /codon_start=1 /product="trifunctional fatty acid synthase subunit FAS2" /protein_id="DAA11205.1" /db_xref="SGD:S000006152" /translation="MKPEVEQELAHILLTELLAYQFASPVRWIETQDVFLKDFNTERV VEIGPSPTLAGMAQRTLKNKYESYDAALSLHREILCYSKDAKEIYYTPDPSELAAKEE PAKEEAPAPTPAASAPAPAAAAPAPVAAAAPAAAAAEIADEPVKASLLLHVLVAHKLK KSLDSIPMSKTIKDLVGGKSTVQNEILGDLGKEFGTTPEKPEETPLEELAETFQDTFS GALGKQSSSLLSRLISSKMPGGFTITVARKYLQTRWGLPSGRQDGVLLVALSNEPAAR LGSEADAKAFLDSMAQKYASIVGVDLSSAASASGAAGAGAAAGAAMIDAGALEEITKD HKVLARQQLQVLARYLKMDLDNGERKFLKEKDTVAELQAQLDYLNAELGEFFVNGVAT SFSRKKARTFDSSWNWAKQSLLSLYFEIIHGVLKNVDREVVSEAINIMNRSNDALIKF MEYHISNTDETKGENYQLVKTLGEQLIENCKQVLDVDPVYKDVAKPTGPKTAIDKNGN ITYSEEPREKVRKLSQYVQEMALGGPITKESQPTIEEDLTRVYKAISAQADKQDISSS TRVEFEKLYSDLMKFLESSKEIDPSQTTQLAGMDVEDALDKDSTKEVASLPNKSTISK TVSSTIPRETIPFLHLRKKTPAGDWKYDRQLSSLFLDGLEKAAFNGVTFKDKYVLITG AGKGSIGAEVLQGLLQGGAKVVVTTSRFSKQVTDYYQSIYAKYGAKGSTLIVVPFNQG SKQDVEALIEFIYDTEKNGGLGWDLDAIIPFAAIPEQGIELEHIDSKSEFAHRIMLTN ILRMMGCVKKQKSARGIETRPAQVILPMSPNHGTFGGDGMYSESKLSLETLFNRWHSE SWANQLTVCGAIIGWTRGTGLMSANNIIAEGIEKMGVRTFSQKEMAFNLLGLLTPEVV ELCQKSPVMADLNGGLQFVPELKEFTAKLRKELVETSEVRKAVSIETALEHKVVNGNS ADAAYAQVEIQPRANIQLDFPELKPYKQVKQIAPAELEGLLDLERVIVVTGFAEVGPW GSARTRWEMEAFGEFSLEGCVEMAWIMGFISYHNGNLKGRPYTGWVDSKTKEPVDDKD VKAKYETSILEHSGIRLIEPELFNGYNPEKKEMIQEVIVEEDLEPFEASKETAEQFKH QHGDKVDIFEIPETGEYSVKLLKGATLYIPKALRFDRLVAGQIPTGWNAKTYGISDDI ISQVDPITLFVLVSVVEAFIASGITDPYEMYKYVHVSEVGNCSGSGMGGVSALRGMFK DRFKDEPVQNDILQESFINTMSAWVNMLLISSSGPIKTPVGACATSVESVDIGVETIL SGKARICIVGGYDDFQEEGSFEFGNMKATSNTLEEFEHGRTPAEMSRPATTTRNGFME AQGAGIQIIMQADLALKMGVPIYGIVAMAATATDKIGRSVPAPGKGILTTAREHHSSV KYASPNLNMKYRKRQLVTREAQIKDWVENELEALKLEAEEIPSEDQNEFLLERTREIH NEAESQLRAAQQQWGNDFYKRDPRIAPLRGALATYGLTIDDLGVASFHGTSTKANDKN ESATINEMMKHLGRSEGNPVIGVFQKFLTGHPKGAAGAWMMNGALQILNSGIIPGNRN ADNVDKILEQFEYVLYPSKTLKTDGVRAVSITSFGFGQKGGQAIVVHPDYLYGAITED RYNEYVAKVSAREKSAYKFFHNGMIYNKLFVSKEHAPYTDELEEDVYLDPLARVSKDK KSGSLTFNSKNIQSKDSYINANTIETAKMIENMTKEKVSNGGVGVDVELITSINVEND TFIERNFTPQEIEYCSAQPSVQSSFAGTWSAKEAVFKSLGVKSLGGGAALKDIEIVRV NKNAPAVELHGNAKKAAEEAGVTDVKVSISHDDLQAVAVAVSTKK" gene 115312..116487 /gene="USV1" /locus_tag="YPL230W" /gene_synonym="NSF1" mRNA 115312..116487 /gene="USV1" /locus_tag="YPL230W" /gene_synonym="NSF1" /product="Usv1p" CDS 115312..116487 /gene="USV1" /locus_tag="YPL230W" /gene_synonym="NSF1" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18667581|PMID:27663510]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:19158363]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:18667581]" /experiment="EXISTENCE:mutant phenotype:GO:0071472 cellular response to salt stress [PMID:18667581]" /note="Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication" /codon_start=1 /product="Usv1p" /protein_id="DAA11206.1" /db_xref="SGD:S000006151" /translation="MENTTNRNTAGVLTSSNGNFATNSVAASTPKRSKSARRKTFKCT GYDGCTMSFTRAEHLARHIRKHTGEKPFQCPACLKFFSRVDNLKQHRESVHAHKNHHS TSSHQRKPSSSSLSSSSSASSSSSASSSTSYSDPYRKTNINSGNMPMMAENEKAPQII HSSPEFITSTRSIPPISPRSIYNTQRQQQHQQQQHQQAPYYFPSHPITDSYYQYPLPS NNNTINYLPSVDVQYPLNVSPSSTSHPASEVIISSFPPRSMPSTSFKYKDSADFQART TMNKYNIRPSNINVNTSNINNHLDSFSPPFSPSTTVAEAKPIILPQYQQAFSQPPNGN KNNNMSSSKNGGKGGENFKNTDDRNDNNNKKRSETLSESDISVNTNKKRLSVDYILT" rep_origin 116566..116680 /note="ARS1607; Autonomously Replicating Sequence" /db_xref="SGD:S000118413" gene 117067..117687 /locus_tag="YPL229W" mRNA 117067..117687 /locus_tag="YPL229W" /product="hypothetical protein" CDS 117067..117687 /locus_tag="YPL229W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11207.1" /db_xref="SGD:S000006150" /translation="MMPYNTPPNIQEPMNFASSNPFGIIPDALSFQNFKYDRLQQQQQ QQQQQQQNRTASSLQQPQQQQPISPPLFLVGAGTSENSNLNKNANTSTIPPLLFSRSS QHYVVPDIDHSSIIYKNNICKSFKDDLFFCPRSLLSLEEQQACEKMDRLTAEQMSLYH QNTQSSSNPGSMSSSPPNSASSIFNSRPKFNPYTSQSFNPLESVQE" gene 118382..120031 /gene="CET1" /locus_tag="YPL228W" /gene_synonym="CES5" mRNA 118382..120031 /gene="CET1" /locus_tag="YPL228W" /gene_synonym="CES5" /product="polynucleotide 5'-phosphatase" CDS 118382..120031 /gene="CET1" /locus_tag="YPL228W" /gene_synonym="CES5" /EC_number="3.6.1.74" /experiment="EXISTENCE:direct assay:GO:0004651 polynucleotide 5'-phosphatase activity [PMID:17707331|PMID:9345280]" /experiment="EXISTENCE:genetic interaction:GO:0031533 mRNA capping enzyme complex [PMID:9710603]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24172134]" /experiment="EXISTENCE:mutant phenotype:GO:1900182 positive regulation of protein localization to nucleus [PMID:24205062]" /experiment="EXISTENCE:physical interaction:GO:0006370 7-methylguanosine mRNA capping [PMID:9345280]" /experiment="EXISTENCE:physical interaction:GO:0031533 mRNA capping enzyme complex [PMID:9710603]" /note="RNA 5'-triphosphatase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of a Cet1p homodimer and two molecules of guanylyltransferase Ceg1p; Cet1p also has a role in regulation of RNAPII pausing at promoter-proximal sites; interaction between Cet1p and Ceg1p is required for Ceg1p nuclear import; mammalian enzyme is single bifunctional polypeptide; human homolog RNGTT can complement yeast cet1 null mutant" /codon_start=1 /product="polynucleotide 5'-phosphatase" /protein_id="DAA11208.1" /db_xref="SGD:S000006149" /translation="MSYTDNPPQTKRALSLDDLVNHDENEKVKLQKLSEAANGSRPFA ENLESDINQTETGQAAPIDNYKESTGHGSHSQKPKSRKSSNDDEETDTDDEMGASGEI NFDSEMDFDYDKQHRNLLSNGSPPMNDGSDANAKLEKPSDDSIHQNSKSDEEQRIPKQ GNEGNIASNYITQVPLQKQKQTEKKIAGNAVGSVVKKEEEANAAVDNIFEEKATLQSK KNNIKRDLEVLNEISASSKPSKYRNVPIWAQKWKPTIKALQSINVKDLKIDPSFLNII PDDDLTKSVQDWVYATIYSIAPELRSFIELEMKFGVIIDAKGPDRVNPPVSSQCVFTE LDAHLTPNIDASLFKELSKYIRGISEVTENTGKFSIIESQTRDSVYRVGLSTQRPRFL RMSTDIKTGRVGQFIEKRHVAQLLLYSPKDSYDVKISLNLELPVPDNDPPEKYKSQSP ISERTKDRVSYIHNDSCTRIDITKVENHNQNSKSRQSETTHEVELEINTPALLNAFDN ITNDSKEYASLIRTFLNNGTIIRRKLSSLSYEIFEGSKKVM" gene complement(120163..121167) /gene="ALG5" /locus_tag="YPL227C" mRNA complement(120163..121167) /gene="ALG5" /locus_tag="YPL227C" /product="dolichyl-phosphate beta-glucosyltransferase" CDS complement(120163..121167) /gene="ALG5" /locus_tag="YPL227C" /EC_number="2.4.1.117" /experiment="EXISTENCE:direct assay:GO:0004581 dolichyl-phosphate beta-glucosyltransferase activity [PMID:8076653]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9560251]" /note="UDP-glucose:dolichyl-phosphate glucosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum; human ortholog ALG5 can partially complement yeast alg5 mutant" /codon_start=1 /product="dolichyl-phosphate beta-glucosyltransferase" /protein_id="DAA11209.1" /db_xref="SGD:S000006148" /translation="MRALRFLIENRNTVFFTLLVALVLSLYLLVYLFSHTPRPPYPEE LKYIAIDEKGHEVSRALPNLNEHQDDEEIFLSVVIPSYNETGRILLMLTDAISFLKEK YGSRWEIVIVDDGSTDNTTQYCLKICKEQFKLNYEQFRIIKFSQNRGKGGAVRQGFLH IRGKYGLFADADGASKFSDVEKLIDAISKIETSSTDLKTTKPAVAIGSRAHMVNTEAV IKRSMIRNCLMYGFHTLVFIFGIRSIKDTQCGFKLFNRAAILKIFPYLHTEGWIFDVE ILILAIRKRIQIEEIPISWHEVDGSKMALAIDSIKMAKDLVIIRMAYLLGIYRDNKKC " gene 121767..125357 /gene="NEW1" /locus_tag="YPL226W" mRNA 121767..125357 /gene="NEW1" /locus_tag="YPL226W" /product="New1p" CDS 121767..125357 /gene="NEW1" /locus_tag="YPL226W" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:31299085]" /experiment="EXISTENCE:mutant phenotype:GO:0006449 regulation of translational termination [PMID:31299085]" /experiment="EXISTENCE:mutant phenotype:GO:0008079 translation termination factor activity [PMID:31299085]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:19806183]" /note="Translation termination and ribosome biogenesis factor; ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction" /codon_start=1 /product="New1p" /protein_id="DAA11210.1" /db_xref="SGD:S000006147" /translation="MPPKKFKDLNSFLDDQPKDPNLVASPFGGYFKNPAADAGSNNAS KKSSYQQQRNWKQGGNYQQGGYQSYNSNYNNYNNYNNYNNYNNYNNYNKYNGQGYQKS TYKQSAVTPNQSGTPTPSASTTSLTSLNEKLSNLELTPISQFLSKIPECQSITDCKNQ IKLIIEEFGKEGNSTGEKIEEWKIVDVLSKFIKPKNPSLVRESAMLIISNIAQFFSGK PPQEAYLLPFFNVALDCISDKENTVKRAAQHAIDSLLNCFPMEALTCFVLPTILDYLS SGAKWQAKMAALSVVDRIREDSANDLLELTFKDAVPVLTDVATDFKPELAKQGYKTLL DYVSILDNLDLSPRYKLIVDTLQDPSKVPESVKSLSSVTFVAEVTEPSLSLLVPILNR SLNLSSSSQEQLRQTVIVVENLTRLVNNRNEIESFIPLLLPGIQKVVDTASLPEVREL AEKALNVLKEDDEADKENKFSGRLTLEEGRDFLLDHLKDIKADDSCFVKPYMNDETVI KYMSKILTVDSNVNDWKRLEDFLTAVFGGSDSQREFVKQDFIHNLRALFYQEKERADE DEGIEIVNTDFSLAYGSRMLLNKTNLRLLKGHRYGLCGRNGAGKSTLMRAIANGQLDG FPDKDTLRTCFVEHKLQGEEGDLDLVSFIALDEELQSTSREEIAAALESVGFDEERRA QTVGSLSGGWKMKLELARAMLQKADILLLDEPTNHLDVSNVKWLEEYLLEHTDITSLI VSHDSGFLDTVCTDIIHYENKKLAYYKGNLAAFVEQKPEAKSYYTLTDSNAQMRFPPP GILTGVKSNTRAVAKMTDVTFSYPGAQKPSLSHVSCSLSLSSRVACLGPNGAGKSTLI KLLTGELVPNEGKVEKHPNLRIGYIAQHALQHVNEHKEKTANQYLQWRYQFGDDREVL LKESRKISEDEKEMMTKEIDIDDGRGKRAIEAIVGRQKLKKSFQYEVKWKYWKPKYNS WVPKDVLVEHGFEKLVQKFDDHEASREGLGYRELIPSVITKHFEDVGLDSEIANHTPL GSLSGGQLVKVVIAGAMWNNPHLLVLDEPTNYLDRDSLGALAVAIRDWSGGVVMISHN NEFVGALCPEQWIVENGKMVQKGSAQVDQSKFEDGGNADAVGLKASNLAKPSVDDDDS PANIKVKQRKKRLTRNEKKLQAERRRLRYIEWLSSPKGTPKPVDTDDEED" gene 126006..126446 /gene="CHP1" /locus_tag="YPL225W" mRNA 126006..126446 /gene="CHP1" /locus_tag="YPL225W" /product="ribosome-associated Tef1p biogenesis chaperone CHP1" CDS 126006..126446 /gene="CHP1" /locus_tag="YPL225W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:38360885]" /experiment="EXISTENCE:direct assay:GO:0044183 protein folding chaperone [PMID:38360885]" /experiment="EXISTENCE:direct assay:GO:0051083 'de novo' cotranslational protein folding [PMID:38360885]" /experiment="EXISTENCE:direct assay:GO:0051787 misfolded protein binding [PMID:38360885]" /experiment="EXISTENCE:direct assay:GO:0061770 translation elongation factor binding [PMID:38360885]" /experiment="EXISTENCE:direct assay:GO:1990593 nascent polypeptide-associated complex binding [PMID:38360885]" /note="Chaperone for eEF1A; ribosome-associated chaperone dedicated to facilitating high-level expression of eEF1A; transiently binds nascent GTPase domain of eEF1A as soon as it emerges from ribosome tunnel; forms complex with NAC by binding UBA domain of Egd2p; inactivation results in disturbed proteostasis and Hsf1p activation due to abberant eEF1A biogenesis; overlapping phenotypes support notion that Chp1p functions in same eEF1A biogenesis pathway as chaperone Zpr1p-Aim29p" /codon_start=1 /product="ribosome-associated Tef1p biogenesis chaperone CHP1" /protein_id="DAA11211.1" /db_xref="SGD:S000006146" /translation="MSTFNAETADNLEDIEKQFAVVAVEQAETYWKLLTSVPGSKLRL TKFDDEIYENFMERFPEYKDVERVKKFTEEELKTKEAKERWRKFFTIFEKKIEDYNFG TLLRTDASAEYGQFTTCFVVRLQFYAFEIARNKHGLNDWIVGQK" gene complement(126634..128088) /gene="MMT2" /locus_tag="YPL224C" /gene_synonym="MFT2" mRNA complement(126634..128088) /gene="MMT2" /locus_tag="YPL224C" /gene_synonym="MFT2" /product="Mmt2p" CDS complement(126634..128088) /gene="MMT2" /locus_tag="YPL224C" /gene_synonym="MFT2" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278|PMID:9353309]" /experiment="EXISTENCE:genetic interaction:GO:0006879 intracellular iron ion homeostasis [PMID:9353309]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:9353309]" /note="Putative metal transporter involved in mitochondrial iron accumulation; MMT2 has a paralog, MMT1, that arose from the whole genome duplication" /codon_start=1 /product="Mmt2p" /protein_id="DAA11212.2" /db_xref="SGD:S000006145" /translation="MLRISIDSIKQFGSFVPGYNNTSYHAAGRAIRTSSLYSTMISAN PRRCLHSSKLLNKEGQEEGYNEQLISKMSSQNGSNSRQNESEGKKEGKASSVKSLLQH THSHSHTHMHDNPLLSLNVQQIKKNPGVRITWIGLASNVGMAVGKFVGGITFHSQALL ADSVHALSDLVSDFLTLFSVQYASRKPTSEYPYGYGKVETVGSLAVSTILAMAGISIG WSSLCAIVGPVIPHAILESMAGLIGETHSHSQSLTQQATNVNAVWIAAGSILVKEWVF QATKKVAIQTNSNVLMANAWHHRVDSLTSLVALVAITSSYFFNIQSLDNLGGLVVSGL IIKTGGQGILSSLKELVDQSIPPTDPRYLEIESVIKDSIGSLKTDLDLKQSLHVRDLT ILASGPNLRATTTLEVPVLHSGQEVGIRFLENAISTIREDLRMKVPNVGKVDVEFVDV TSDSKGDLEHSHDTKSTNHTHTHSDSADTHTHKH" gene complement(128632..129138) /gene="GRE1" /locus_tag="YPL223C" mRNA complement(128632..129138) /gene="GRE1" /locus_tag="YPL223C" /product="Gre1p" CDS complement(128632..129138) /gene="GRE1" /locus_tag="YPL223C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /note="Hydrophilin essential in desiccation-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; GRE1 has a paralog, SIP18, that arose from the whole genome duplication" /codon_start=1 /product="Gre1p" /protein_id="DAA11213.1" /db_xref="SGD:S000006144" /translation="MSNLLNKFADKLHGNDHDERYEDDNDDQTRQQRHEKHQQREFRN QGSKADPYGEENQGNFPQRQQPQSNLGGNTQFGGNDFQQQTTDYTAGTGGGTYTQTYR ETNTQGQLDDDEDDDFLTSGQQQKQGRTRGAQSNRYQSSNIGSGRRDLSGSGNDEYDD DSGNQGVW" gene 130162..132228 /gene="FMP40" /locus_tag="YPL222W" mRNA 130162..132228 /gene="FMP40" /locus_tag="YPL222W" /product="Fmp40p" CDS 130162..132228 /gene="FMP40" /locus_tag="YPL222W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:30270044|PMID:14576278|PMID:24769239|PMID:14562095|P MID:16823961]" /experiment="EXISTENCE:direct assay:GO:0018117 protein adenylylation [PMID:30270044]" /experiment="EXISTENCE:direct assay:GO:0045454 cell redox homeostasis [PMID:30270044]" /experiment="EXISTENCE:direct assay:GO:0070733 AMPylase activity [PMID:30270044]" /note="Mitochondrial AMPylator in the pseudokinase selenoprotein-O family; role in the oxidative stress response, transferring AMP from ATP to protein substrates (AMPylation) involved in redox homeostasis; regulates S-glutathionylation levels; proposed involvement in the environmental stress response" /codon_start=1 /product="Fmp40p" /protein_id="DAA11214.1" /db_xref="SGD:S000006143" /translation="MGEKRTIIKALKNSAASHFIKKLTADTSLSSIQEAINVVQQYNA TDPVRLKLFHTPRMVSQGAHFAFCLPTKKPHYKPLLLSQNALDEFNLVQDQDLEKILS GEKVYYSDSIFPYSTVYSGFQFGSFAAQLGDGRVVNLFDLKDKCSGQWQTFQLKGAGM TPFSRFADGKAVLRSSIREFIMSEALHSIGIPSTRAMQLTLLPGTKAQRRNQEPCAVV CRFAPSWIRLGNFNLFRWRHDLKGLIQLSDYCIEELFAGGTQFEGKPDFNIFKRDFFP DTETKIDEQVEKDETEVSTMTGDNISTLSKYDEFFRHVVSLNANTVAHWQAYGFANGV LNTDNTSIMGLTIDYGPFAFLDKFEPSFTPNHDDTAKRYSFANQPSIIWWNLQQFAKD LACLLGPEARDLELLLKGELNSVDDALEKTMIERVQKLVELSANEYKYVFTTRYAQIM SQRLGVDLDLEKCMSSTNLKDIEHAAEKAKEFCDVIVEPLLDILQATKVDYNNFFIHL QNYKGPFFIKDKSDTATLFGAFDEEYLGMFFNSKQLQQMAETEEAFAAGEKVFDANGE LRLLNEKLQEIRNWTQDYLTLVPPTETAARASLAKKANPLFVPRSWVLEEVVDDLMYS QRDGLQDPSSELDTSALKKLYLMSVNPYDRTKWDVTLRPELETKWADLSHQDDAKFMM QASCSS" gene 133043..135424 /gene="FLC1" /locus_tag="YPL221W" mRNA 133043..135424 /gene="FLC1" /locus_tag="YPL221W" /product="flavin adenine dinucleotide transporter" CDS 133043..135424 /gene="FLC1" /locus_tag="YPL221W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16717099]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0030148 sphingolipid biosynthetic process [PMID:27462707]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:16717099]" /experiment="EXISTENCE:mutant phenotype:GO:0009272 fungal-type cell wall biogenesis [PMID:16717099]" /experiment="EXISTENCE:mutant phenotype:GO:0015230 FAD transmembrane transporter activity [PMID:16717099]" /experiment="EXISTENCE:mutant phenotype:GO:0015883 FAD transport [PMID:16717099]" /note="Flavin adenine dinucleotide transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC1 has a paralog, FLC3, that arose from the whole genome duplication" /codon_start=1 /product="flavin adenine dinucleotide transporter" /protein_id="DAA11215.1" /db_xref="SGD:S000006142" /translation="MQVLVTLWCLICTCLVLPVAAKKRTLTASSLVTCMENSQLSANS FDVSFSPDDRSLHYDLDMTTQIDSYIYAYVDVYAYGFKIITENFDVCSMGWKQFCPVH PGNIQIDSIEYIAQKYVKMIPGIAYQVPDIDAYVRLNIYNNVSENLACIQVFFSNGKT VSQIGVKWVTAVIAGIGLLTSAVLSTFGNSTAASHISANTMSLFLYFQSVAVVAMQHV DSVPPIAAAWSENLAWSMGLIRITFMQKIFRWYVEATGGSASLYLTATTMSVLTQRGL DYLKNTSVYKRAENVLYGNSNTLIFRGIKRMGYRMKIENTAIVCTGFTFFVLCGYFLA GFIMACKYSIELCIRCGWMRSDRFYQFRKNWRSVLKGSLLRYIYIGFTQLTILSFWEF TERDSAGVIVIACLFIVLSCGLMAWAAYRTIFFASKSVEMYNNPAALLYGDEYVLNKY GFFYTMFNAKHYWWNALLTTYILVKALFVGFAQASGKTQALAIFIIDLAYFVAIIRYK PYLDRPTNIVNIFICTVTLVNSFLFMFFSNLFNQKYAVSAIMGWVFFIMNAAFSLLLL LMILAFTTIILFSKNPDSRFKPAKDDRASFQKHAIPHEGALNKSVANELMALGNVAKD HTENWEYELKSQEGKSEDNLFGVEYDDEKTGTNSENAESSSKETTRPTFSEKVLRSLS IKRNKSKLGSFKRSAPDKITQQEVSPDRASSSPNSKSYPGVSHTRQESEANNGLINAY EDEQFSLMEPSILEDAASSTQMHAMPARDLSLSSVANAQDVTKKANILDPDYL" gene 135790..136443 /gene="RPL1A" /locus_tag="YPL220W" /gene_synonym="PUB2" /gene_synonym="SSM1" mRNA 135790..136443 /gene="RPL1A" /locus_tag="YPL220W" /gene_synonym="PUB2" /gene_synonym="SSM1" /product="ribosomal 60S subunit protein L1A" CDS 135790..136443 /gene="RPL1A" /locus_tag="YPL220W" /gene_synonym="PUB2" /gene_synonym="SSM1" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:31439809]" /note="Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal; ribosomes containing Rpl1b are more efficient in translation of respiration-related proteins" /codon_start=1 /product="ribosomal 60S subunit protein L1A" /protein_id="DAA11216.1" /db_xref="SGD:S000006141" /translation="MSKITSSQVREHVKELLKYSNETKKRNFLETVELQVGLKNYDPQ RDKRFSGSLKLPNCPRPNMSICIFGDAFDVDRAKSCGVDAMSVDDLKKLNKNKKLIKK LSKKYNAFIASEVLIKQVPRLLGPQLSKAGKFPTPVSHNDDLYGKVTDVRSTIKFQLK KVLCLAVAVGNVEMEEDVLVNQILMSVNFFVSLLKKNWQNVGSLVVKSSMGPAFRLY" gene 136750..138228 /gene="PCL8" /locus_tag="YPL219W" mRNA 136750..138228 /gene="PCL8" /locus_tag="YPL219W" /product="Pcl8p" CDS 136750..138228 /gene="PCL8" /locus_tag="YPL219W" /experiment="EXISTENCE:genetic interaction:GO:0045719 negative regulation of glycogen biosynthetic process [PMID:9584169]" /experiment="EXISTENCE:mutant phenotype:GO:0045719 negative regulation of glycogen biosynthetic process [PMID:9584169]" /note="Cyclin; interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation; PCL8 has a paralog, PCL10, that arose from the whole genome duplication" /codon_start=1 /product="Pcl8p" /protein_id="DAA11217.1" /db_xref="SGD:S000006140" /translation="MANDQDPNKSLINDALTRSMSEFYDDDDDNDSDMCRANDEGEDV FDLPLKVGVSQSRNFSEVNDVLDPLSSLHGPSKKVRFEQQKQQQQHQQLHNDFNTDFN LKSPSSKKMGVEQLIQSANEINDYLANNIDKVNSFNSELLSGSGKLPGRVKSDTATQG TGRLDSMSNFALSDTELDNDDDNYLLDPLANASSTTPTVEHHGYSLLDKALSTSDKEK IYTNKVNSNSQIDTDNHSHESGNTTNNETDENESSEILDYTKFDSFPYPPSSAPNGEP PDLKVLSIECEQENEKELRRISLLLDHYESIPKIPELSDDEALSKFRENIELILQLSK KINDNANTLAISSEDPQKFVNFVMKNPPSLSFRDFIDRIQNKCMFGAVVYLGATYLLQ LVFLTRDEMDGPIKLKAKLQEDQAHRIIISTIRIATKLLEDFVHSQNYICKVFGISKR LLTKLEISFMASVNFDGLMITCEKLEKTLHILDDTRQALGNT" gene 138698..139409 /gene="SAR1" /locus_tag="YPL218W" mRNA join(138698..138725,138865..139409) /gene="SAR1" /locus_tag="YPL218W" /product="Arf family GTPase SAR1" CDS join(138698..138725,138865..139409) /gene="SAR1" /locus_tag="YPL218W" /experiment="EXISTENCE:direct assay:GO:0003400 regulation of COPII vesicle coating [PMID:14627716|PMID:15665868]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:8419365|PMID:9756629]" /experiment="EXISTENCE:direct assay:GO:0016050 vesicle organization [PMID:16122427]" /experiment="EXISTENCE:direct assay:GO:0030127 COPII vesicle coat [PMID:8004676]" /experiment="EXISTENCE:direct assay:GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site [PMID:27101143]" /experiment="EXISTENCE:direct assay:GO:0070971 endoplasmic reticulum exit site [PMID:22675024]" /experiment="EXISTENCE:genetic interaction:GO:0000266 mitochondrial fission [PMID:27101143]" /experiment="EXISTENCE:mutant phenotype:GO:0006998 nuclear envelope organization [PMID:31406088]" /experiment="EXISTENCE:mutant phenotype:GO:0007006 mitochondrial membrane organization [PMID:27101143]" /experiment="EXISTENCE:mutant phenotype:GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site [PMID:27101143]" /experiment="EXISTENCE:mutant phenotype:GO:0061024 membrane organization [PMID:27101143]" /note="ARF family GTPase; component of the COPII vesicle coat; required for transport vesicle formation during ER to Golgi protein transport; lowers membrane rigidity aiding vesicle formation; localizes to ER-mitochondrial contact sites where it enhances membrane curvature, thereby reducing contact size via its N-terminal amphipathic helix; regulates mitochondrial fission and fusion dynamics" /codon_start=1 /product="Arf family GTPase SAR1" /protein_id="DAA11218.1" /db_xref="SGD:S000006139" /translation="MAGWDIFGWFRDVLASLGLWNKHGKLLFLGLDNAGKTTLLHMLK NDRLATLQPTWHPTSEELAIGNIKFTTFDLGGHIQARRLWKDYFPEVNGIVFLVDAAD PERFDEARVELDALFNIAELKDVPFVILGNKIDAPNAVSEAELRSALGLLNTTGSQRI EGQRPVEVFMCSVVMRNGYLEAFQWLSQYI" gene complement(139620..143171) /gene="BMS1" /locus_tag="YPL217C" mRNA complement(139620..143171) /gene="BMS1" /locus_tag="YPL217C" /product="GTPase BMS1" CDS complement(139620..143171) /gene="BMS1" /locus_tag="YPL217C" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:16307926]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:16307926]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:16307926]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11565749]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11565749]" /experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:16307926]" /experiment="EXISTENCE:mutant phenotype:GO:0005525 GTP binding [PMID:16307926]" /note="GTPase required for ribosomal subunit synthesis and rRNA processing; required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p" /codon_start=1 /product="GTPase BMS1" /protein_id="DAA11219.1" /db_xref="SGD:S000006138" /translation="MEQSNKQHRKAKEKNTAKKKLHTQGHNAKAFAVAAPGKMARTMQ RSSDVNERKLHVPMVDRTPEDDPPPFIVAVVGPPGTGKTTLIRSLVRRMTKSTLNDIQ GPITVVSGKHRRLTFLECPADDLNAMIDIAKIADLVLLLIDGNFGFEMETMEFLNIAQ HHGMPRVLGVATHLDLFKSQSTLRASKKRLKHRFWTEVYQGAKLFYLSGVINGRYPDR EILNLSRFISVMKFRPLKWRNEHPYMLADRFTDLTHPELIETQGLQIDRKVAIYGYLH GTPLPSAPGTRVHIAGVGDFSVAQIEKLPDPCPTPFYQQKLDDFEREKMKEEAKANGE ITTASTTRRRKRLDDKDKLIYAPMSDVGGVLMDKDAVYIDIGKKNEEPSFVPGQERGE GEKLMTGLQSVEQSIAEKFDGVGLQLFSNGTELHEVADHEGMDVESGEESIEDDEGKS KGRTSLRKPRIYGKPVQEEDADIDNLPSDEEPYTNDDDVQDSEPRMVEIDFNNTGEQG AEKLALETDSEFEESEDEFSWERTAANKLKKTESKKRTWNIGKLIYMDNISPEECIRR WRGEDDDSKDESDIEEDVDDDFFRKKDGTVTKEGNKDHAVDLEKFVPYFDTFEKLAKK WKSVDAIKERFLGAGILGNDNKTKSDSNEGGEELYGDFEDLEDGNPSEQAEDNSDKES EDEDENEDTNGDDDNSFTNFDAEEKKDLTMEQEREMNAAKKEKLRAQFEIEEGENFKE DDENNEYDTWYELQKAKISKQLEINNIEYQEMTPEQRQRIEGFKAGSYVRIVFEKVPM EFVKNFNPKFPIVMGGLLPTEIKFGIVKARLRRHRWHKKILKTNDPLVLSLGWRRFQT LPIYTTTDSRTRTRMLKYTPEHTYCNAAFYGPLCSPNTPFCGVQIVANSDTGNGFRIA ATGIVEEIDVNIEIVKKLKLVGFPYKIFKNTAFIKDMFSSAMEVARFEGAQIKTVSGI RGEIKRALSKPEGHYRAAFEDKILMSDIVILRSWYPVRVKKFYNPVTSLLLKEKTEWK GLRLTGQIRAAMNLETPSNPDSAYHKIERVERHFNGLKVPKAVQKELPFKSQIHQMKP QKKKTYMAKRAVVLGGDEKKARSFIQKVLTISKAKDSKRKEQKASQRKERLKKLAKME EEKSQRDKEKKKEYFAQNGKRTTMGGDDESRPRKMRR" gene 143821..147129 /locus_tag="YPL216W" mRNA 143821..147129 /locus_tag="YPL216W" /product="hypothetical protein" CDS 143821..147129 /locus_tag="YPL216W" /note="hypothetical protein; not an essential gene; YPL216W has a paralog, ITC1, that arose from the whole genome duplication" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11220.1" /db_xref="SGD:S000006137" /translation="MVLLNRRKIQPKEIGQSADSFSETPWVIKESSERINDYDSDLKK LDFYKRDIFTCEISGKDGLSYFKALKSEEQHREKVRYLLPKELRKAIANFANFSPIRK VGHLVESAFQRFSNRFFIGDTVCLKTIQKNALITYKEGEPNLVESPTIENNVTLFLVK DVFQSNGMMESEKGEISAPKLSLYLITECLNRESKGAALIVGQNEIKRPESHFSKFII ACFLNEILIKVSNKEHAPWRVKQEYIERYDVNPKCSPNMIDYLPDRMNSSSSELYTPL TIPPESDVEPADWKETSETSETSETSLSKIKAIDDEISVSFDHIYDNVNSLAYNDLKG TVDDKELPFTGPSIPFENISYLDSSLEYKNIDQKWFKECSQFPTERLLVVYQFLSFFG RFIGLSHFNFDQFLTTIKCTSPEALVDEYVKINFLKTYNSKGSFTNEKPRNEIYNQVT SSNVSQREKANVFNADESQRIPSNFTRNQKMRKFITDKSTEFVMYSIFKGKPLKNDDM EFQSYEKVNILYIDIVCSLMCLMTDNEPDWNCNLMDNWTEEKRKEEGNKTEIDIAIEK CLNYGDTSWVKLLHNKNFSNGNWLICLLGILQQNTHMIAYSDVAKCITKKILPLSMNF VNLGDELWDNFRKRLSIKDKIDVLWVLVDFASNFSSYIKELVDKVPKLCNGIRLKLDS AKKEYIKLKRQLKTLTKNRVKLHSNVSMNRYGSDECKGKVNALKVKIAYLMEDIAFLE AKLIQSDIKRLEILGKDRNGNRYYWMDSNGSSSAISEKNEELYNCCFLWVQGPSEADI NFCLDVDVESLKKWELLAKAKGTAYATKEVFSIFRSTDGSYYQIAQGENFMIINSNGI LMRPTIPAFIDKKIISETPEKLLLSHHQWAFFNDIEDIHMLVDRLDDLRENEGQLKKA LTSKMDRIEVSYKQQFKIKRRIECDETFKKNHKLLKNNEFTFPELKRIETTCTSNGQH FSNMEKISKKLSRTKNDLVLEAILKDVAHLGECERALLKKQQNLIYPLNFHFEQLRTI DLEFIVETKRKRQEDILTKLLNHQRYKHISHVSGYGISSQRVDKAAHLDVQGILEEIE CQLISRRREDEERN" gene 147416..148423 /gene="CBP3" /locus_tag="YPL215W" mRNA 147416..148423 /gene="CBP3" /locus_tag="YPL215W" /product="Cbp3p" CDS 147416..148423 /gene="CBP3" /locus_tag="YPL215W" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:29475949]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:11522252]" /experiment="EXISTENCE:direct assay:GO:0005761 mitochondrial ribosome [PMID:21670217]" /experiment="EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:11522252]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:21670217]" /experiment="EXISTENCE:mutant phenotype:GO:0034551 mitochondrial respiratory chain complex III assembly [PMID:11522252|PMID:15759116]" /experiment="EXISTENCE:mutant phenotype:GO:0070131 positive regulation of mitochondrial translation [PMID:21670217]" /experiment="EXISTENCE:physical interaction:GO:0043022 ribosome binding [PMID:21670217]" /experiment="EXISTENCE:physical interaction:GO:0061671 Cbp3p-Cbp6 complex [PMID:21670217]" /note="Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation" /codon_start=1 /product="Cbp3p" /protein_id="DAA11221.1" /db_xref="SGD:S000006136" /translation="MMSVNRFTSGRLPVFLRKSPFYYSRAYLHQTCVFKQNKETAQDS PELLAKSSHLNSKPLDVSNKAPVKTAQNKIPLAHSKYESSKYELPKWKEALGELVIRA FHLDMDRVRAGPVAGSYYYKICKEQGLQYEDEPLSETAKYFYEDLKLPRTFSQWFQIT VLHEWILFVRMRAMPFKYGRNYQQKLVDRTFSDIELRLFEEMKVNSGRIADQYLKDFN TQLRGAIFAYDEGFATDDGTLATAVWRNLFGGRKNIDMVHLESVVRYIYSQLYVLSRL SDREFATGKFKFVPPGVKVEKLTPKQEEELKAKTIAKYEALDKDPKTLPSERSRLSYT N" gene complement(148569..150191) /gene="THI6" /locus_tag="YPL214C" mRNA complement(148569..150191) /gene="THI6" /locus_tag="YPL214C" /product="bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase" CDS complement(148569..150191) /gene="THI6" /locus_tag="YPL214C" /EC_number="2.5.1.3" /EC_number="2.7.1.50" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16850348]" /experiment="EXISTENCE:mutant phenotype:GO:0004417 hydroxyethylthiazole kinase activity [PMID:7982968]" /experiment="EXISTENCE:mutant phenotype:GO:0004789 thiamine-phosphate diphosphorylase activity [PMID:7982968]" /experiment="EXISTENCE:mutant phenotype:GO:0009228 thiamine biosynthetic process [PMID:7982968]" /note="Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase; required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern" /codon_start=1 /product="bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase" /protein_id="DAA11222.1" /db_xref="SGD:S000006135" /translation="MVFTKEEVDYSLYLVTDSTMLPPGTTLCSQVEAGLKNGVTLVQI REKDIETKNFVAEALEVQKICKKYNVPLIINDRIDVAMAIDADGVHVGQDDMPIPMVR KLLGPSKILGWSVGKPSEVETLAKWGPDMVDYIGVGTLFPTSTKKNPKKSPMGPQGAI AILDALEEFKATWCRTVGIGGLHPDNIQRVLCQCVASNGKRSLDGISLVSDIMAAPDA CAATKRLRGLLDATRYQFVECELNNTFPTTTSIQNVISQVSNNRPLVQHITNKVHQNF GANVTLALGSSPIMSEIESEVSELARIPNASLLLNTGSVAPIEMLKAAINAYNEVNRP ITFDPVGYSATETRLCLNNTLLTYGQFACIKGNCSEILSLAKLNNHKMKGVDSSSGKT NIDTLVRATQIVAFQYRTVAVCTGEFDCVADGTFGGEYKLSSGTEGITAEDLPCVIIE DGPIPIMGDITASGCSLGSTIASFIGGLDSTGKLFDAVVGAVLLYKSAGKLASTRCQG SGSFHVELIDALYQLFHENKPEKWSASLKKFK" gene 150614..151330 /gene="LEA1" /locus_tag="YPL213W" mRNA 150614..151330 /gene="LEA1" /locus_tag="YPL213W" /product="U2 snRNP complex subunit LEA1" CDS 150614..151330 /gene="LEA1" /locus_tag="YPL213W" /experiment="EXISTENCE:direct assay:GO:0005686 U2 snRNP [PMID:9799242]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:9799242]" /experiment="EXISTENCE:physical interaction:GO:0005686 U2 snRNP [PMID:9799242]" /note="Component of U2 snRNP complex; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein" /codon_start=1 /product="U2 snRNP complex subunit LEA1" /protein_id="DAA11223.1" /db_xref="SGD:S000006134" /translation="MKFTPSIVIDAPQYYVDHFNGKYNVDKCVILRDLQLETDSESMP SSLKHLTKPTHILDLTNNDLIMIPDLSRRDDIHTLLLGRNNIVEVDGRLLPMNVQNLT LSNNSIRRFEDLQRLRRAPRTLKNLTLIGNQVCHLANYREHVLRLVPHLETLDFQNVT AEERKSAMSFPRQADGDTLGPVNTAIRDNGSRDKTMEIMNLVVSKMTVERRNELKKQL AEATSLEEIARLEKLLSGGV" gene complement(151515..153149) /gene="PUS1" /locus_tag="YPL212C" mRNA complement(151515..153149) /gene="PUS1" /locus_tag="YPL212C" /product="pseudouridine synthase PUS1" CDS complement(151515..153149) /gene="PUS1" /locus_tag="YPL212C" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8641292]" /experiment="EXISTENCE:direct assay:GO:0009982 pseudouridine synthase activity [PMID:10356324]" /experiment="EXISTENCE:direct assay:GO:0031119 tRNA pseudouridine synthesis [PMID:10356324]" /experiment="EXISTENCE:mutant phenotype:GO:0031120 snRNA pseudouridine synthesis [PMID:10022901]" /experiment="EXISTENCE:mutant phenotype:GO:1990481 mRNA pseudouridine synthesis [PMID:25219674|PMID:25192136]" /note="tRNA:pseudouridine synthase; introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; also acts on U2 snRNA; also pseudouridylates some mRNAs, and pseudouridylation level varies with growth phase; nuclear protein that appears to be involved in tRNA export; PUS1 has a paralog, PUS2, that arose from the whole genome duplication" /codon_start=1 /product="pseudouridine synthase PUS1" /protein_id="DAA11224.1" /db_xref="SGD:S000006133" /translation="MSEENLRPAYDDQVNEDVYKRGAQSKLTKARKADFDDEKDKKKD NDKHIDKRPKSGPRLDENGNPLPKEPRLPKRKVAVMVGYCGTGYHGMQYNPPNPTIES ALFKAFVEAGAISKDNSNDLKKNGFMRAARTDKGVHAGGNLISLKMIIEDPDIKQKIN EKLPEGIRVWDIERVNKAFDCRKMCSSRWYEYLLPTYSLIGPKPGSILYRDIEESKTE LPGVLDEDLESKEFWEEFKKDANEKFSTEEIEAILAYVPPARDEFDINEELYQKVKKY KQLENAHRRRYRISAAKLAKFRASTSQYLGAHNFHNFTLGKDFKEPSAIRFMKDIKVS DPFVIGDAQTEWISIKIHGQSFMLHQIRKMVSMATLITRCGCPVERISQAYGQQKINI PKAPALGLLLEAPVFEGYNKRLEQFGYKAIDFSKYQDEVDKFKMKHIYDKIYKEEVDE NVFNAFFSYIDSFNKVTGAQGEETADKSGPAVQKSIFEFLTAKGIPGLTDAPESNKKI KQRKRMEEEEAASKKAEISSTTQSNEPEVQPEAAAN" gene 153495..154040 /gene="NIP7" /locus_tag="YPL211W" mRNA 153495..154040 /gene="NIP7" /locus_tag="YPL211W" /product="ribosome biosynthesis protein NIP7" CDS 153495..154040 /gene="NIP7" /locus_tag="YPL211W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9271378|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9271378]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17443350|PMID:11583614|PMID:23212245]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9271378]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:9271378]" /experiment="EXISTENCE:mutant phenotype:GO:1902626 assembly of large subunit precursor of preribosome [PMID:22735702]" /note="Nucleolar protein required for 60S ribosome subunit biogenesis; constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p" /codon_start=1 /product="ribosome biosynthesis protein NIP7" /protein_id="DAA11225.1" /db_xref="SGD:S000006132" /translation="MRQLTEEETKVVFEKLAGYIGRNISFLVDNKELPHVFRLQKDRV YYVPDHVAKLATSVARPNLMSLGICLGKFTKTGKFRLHITSLTVLAKHAKYKIWIKPN GEMPFLYGNHVLKAHVGKMSDDIPEHAGVIVFAMNDVPLGFGVSAKSTSESRNMQPTG IVAFRQADIGEYLRDEDTLFT" gene complement(154290..156212) /gene="SRP72" /locus_tag="YPL210C" mRNA complement(154290..156212) /gene="SRP72" /locus_tag="YPL210C" /product="signal recognition particle subunit SRP72" CDS complement(154290..156212) /gene="SRP72" /locus_tag="YPL210C" /experiment="EXISTENCE:direct assay:GO:0005786 signal recognition particle, endoplasmic reticulum targeting [PMID:7925282]" /experiment="EXISTENCE:direct assay:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:10921896]" /note="Core component of the signal recognition particle (SRP); the SRP is a ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane" /codon_start=1 /product="signal recognition particle subunit SRP72" /protein_id="DAA11226.1" /db_xref="SGD:S000006131" /translation="MAKDNLTNLLSQLNIQLSQDEHSQVEQTCVKLLDSGCENPADVF RRCLVAVIQQDKYQKALHYLKKFKHIDDKYGRKFALEKLYIFYKLNMPDEFNTLYTAI ITDDLDTVLKKDIESLRGILHVRAQYCYKNGLYQEAFKIYQHLASHNEKDQDSQIELS CNERVPLSVATELMNRSPLVTPMDESSYDLLFNESFIMASVGKYDKAIELLEKALQGA TNEGYQNDINTIKLQLSFVLQMVGKTAQSKEILKGLLQELKADSPFSLICQNNLNAFV DFSKYNTNFNLLLRELNVEKLNTFNLQTFTHEQWSNIQRNVLFLRLFNNVKIHSQESL LSRTFDKYSKLVDNVTLESYKTQAKKLYHHTTKTILSGTDGSTIGILLLTIQLLIIEK EWENAIRIGELFLNESWKSSFEKFNDSQAIVCYILFELYKIKGRNNSKSVLLKKLGSV RVQLSGKIQENIPFWKHVGFELLSMGNAKESKALLREISNFSKGDADVLVDRVVSSDS LDIAQGIDLVRDIDIDKLIQLGVKPLESSAKRSKNTAVSKVQKRKVLELKKKRKIKRL EKFLQGRDTSKLPDPERWLPLRDRSTYRPKKKQQGAKQTQGGAMNKKSEQALDISKKG KPTVNKKPKNKKKGRK" gene complement(156490..157593) /gene="IPL1" /locus_tag="YPL209C" /gene_synonym="PAC15" mRNA complement(156490..157593) /gene="IPL1" /locus_tag="YPL209C" /gene_synonym="PAC15" /product="aurora kinase" CDS complement(156490..157593) /gene="IPL1" /locus_tag="YPL209C" /gene_synonym="PAC15" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11511347|PMID:12566427]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:11799062|PMID:10072382|PMID:16319894|PMID:16143104|P MID:23142046|PMID:25387524]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005819 spindle [PMID:12566427]" /experiment="EXISTENCE:direct assay:GO:0005828 kinetochore microtubule [PMID:11724818]" /experiment="EXISTENCE:direct assay:GO:0005874 microtubule [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:11511347|PMID:11724818]" /experiment="EXISTENCE:direct assay:GO:0032133 chromosome passenger complex [PMID:19158380]" /experiment="EXISTENCE:direct assay:GO:0051233 spindle midzone [PMID:12566427]" /experiment="EXISTENCE:genetic interaction:GO:0044774 mitotic DNA integrity checkpoint signaling [PMID:16651657]" /experiment="EXISTENCE:genetic interaction:GO:0044779 meiotic spindle checkpoint signaling [PMID:37018287]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:8293973]" /experiment="EXISTENCE:mutant phenotype:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:10072382]" /experiment="EXISTENCE:mutant phenotype:GO:0032465 regulation of cytokinesis [PMID:16615892]" /experiment="EXISTENCE:mutant phenotype:GO:0045143 homologous chromosome segregation [PMID:17289568]" /experiment="EXISTENCE:mutant phenotype:GO:0045144 meiotic sister chromatid segregation [PMID:17289568|PMID:17371833]" /experiment="EXISTENCE:mutant phenotype:GO:0051228 mitotic spindle disassembly [PMID:12566427]" /experiment="EXISTENCE:mutant phenotype:GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint [PMID:16327780]" /experiment="EXISTENCE:mutant phenotype:GO:1901673 regulation of mitotic spindle assembly [PMID:24386320]" /experiment="EXISTENCE:mutant phenotype:GO:1901925 negative regulation of protein import into nucleus during spindle assembly checkpoint [PMID:23177738]" /note="Aurora kinase of the chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in MI, and kinetochore release from SPB clusters during meiotic exit; maintains meiotic spindle checkpoint delay in a mek1 null; maintains condensed chromosomes in anaphase; required for SPB cohesion and preventing multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; inhibits Pse1p upon SAC arrest" /codon_start=1 /product="aurora kinase" /protein_id="DAA11227.1" /db_xref="SGD:S000006130" /translation="MQRNSLVNIKLNANSPSKKTTTRPNTSRINKPWRISHSPQQRNP NSKIPSPVREKLNRLPVNNKKFLDMESSKIPSPIRKATSSKMIHENKKLPKFKSLSLD DFELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTSLN HPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILASDYIYQIANALDYM HKKNIIHRDIKPENILIGFNNVIKLTDFGWSIINPPENRRKTVCGTIDYLSPEMVESR EYDHTIDAWALGVLAFELLTGAPPFEEEMKDTTYKRIAALDIKMPSNISQDAQDLILK LLKYDPKDRMRLGDVKMHPWILRNKPFWENKRL" gene 157842..159593 /gene="RKM1" /locus_tag="YPL208W" mRNA 157842..159593 /gene="RKM1" /locus_tag="YPL208W" /product="protein-lysine N-methyltransferase" CDS 157842..159593 /gene="RKM1" /locus_tag="YPL208W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016279 protein-lysine N-methyltransferase activity [PMID:16096273]" /experiment="EXISTENCE:direct assay:GO:0018027 peptidyl-lysine dimethylation [PMID:16096273]" /experiment="EXISTENCE:mutant phenotype:GO:0016279 protein-lysine N-methyltransferase activity [PMID:16096273]" /experiment="EXISTENCE:mutant phenotype:GO:0018026 peptidyl-lysine monomethylation [PMID:22522802]" /experiment="EXISTENCE:mutant phenotype:GO:0018027 peptidyl-lysine dimethylation [PMID:16096273]" /note="SET-domain lysine-N-methyltransferase; catalyzes the formation of dimethyllysine residues on the large ribosomal subunit proteins L23 (Rpl23Ap and Rpl23Bp) and monomethyllysine residues on L18 (Rps18Ap and Rps18Bp)" /codon_start=1 /product="protein-lysine N-methyltransferase" /protein_id="DAA11228.1" /db_xref="SGD:S000006129" /translation="MSSDALKALLQWGASFGVIVPEELKFLYTDLKGIICVCEKDIDN PSIKIPPEIVISRNLPMKFFGLSESTKNINGWLKLFFAKIKFDRDNDTIVDNVRVNDK FKPYLDALPSRLNSPLVWNPSELKRLSSTNIGNSIHEKFEGIFKEWFELVSSSDMFDL ERVADDVQTFHNLDELTYEALYEKILKITELQRPTIWYSFPAFLWSHLIFISRAFPEY VLNRNCPDNSIVLLPIVDLLNHDYRSKVKWYPENGWFCYEKIGTASQSRELSNNYGGK GNEELLSGYGFVLEDNIFDSVALKVKLPLDVVSTILETEPSLKLPLLSDYTTYAFENK DCVQQEKKATRSATDYINGVTYFINIQNEQCLEPLLDLFTYLSKAEEEDLHDLRARLQ GIQMLRNALQSKLNSITGPPATDDSYAIDPYRVYCADVYTKGQKQILKEALTRLKKLE KTMLSENKHQLLTMSKILKNDPAFAETELPSLFSNEDGEEVIFESTYDLLILWILLKT KKNSYPTKYEWVGQQYTNFKQTAYISDDAKAFHTAYFEKQDDVDLAEVDHAIQFVVDN SFTRTSSTTEETILVRK" gene 159909..162341 /gene="TYW1" /locus_tag="YPL207W" mRNA 159909..162341 /gene="TYW1" /locus_tag="YPL207W" /product="putative tRNA 4-demethylwyosine synthase" CDS 159909..162341 /gene="TYW1" /locus_tag="YPL207W" /EC_number="4.1.3.44" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031591 wybutosine biosynthetic process [PMID:34184886]" /experiment="EXISTENCE:direct assay:GO:1904047 S-adenosyl-L-methionine binding [PMID:34184886]" /experiment="EXISTENCE:mutant phenotype:GO:0031591 wybutosine biosynthetic process [PMID:17150819|PMID:16642040|PMID:16162496]" /note="Iron-sulfur protein required for synthesis of wybutosine modified tRNA; wybutosine is a modified guanosine found at 3'-position adjacent to anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron" /codon_start=1 /product="putative tRNA 4-demethylwyosine synthase" /protein_id="DAA11229.1" /db_xref="SGD:S000006128" /translation="MDGFRVAGALVVGALTAAYLYFGGRFSIALVIIVGYGIYCNEAS GGSQDSQEKLDLNKQQKKPCCSDKKIADGGKKTGGCCSDKKNGGGKGGGCCSSKGGKK GGCCSSKGGKKGGCCSSKKNIGDNENTATEVEKAVNYPVTVDFTEVFRKPTKKRSSTP KVFSKNSSSNSRVGKKLSVSKKIGPDGLIKSALTISNETLLSSQIYVLYSSLQGAASK AAKSVYDKLKELDELTNEPKLLNLDDLSDFDDYFINVPVENALYVLVLPSYDIDCPLD YFLQTLEENANDFRVDSFPLRKLVGYTVLGLGDSESWPEKFCYQAKRADHWISRLGGR RIFPLGKVCMKTGGSAKIDEWTSLLAETLKDDEPIIYEYDENADSEEDEEEGNGSDEL GDVEDIGGKGSNGKFSGADEIKQMVAKDSPTYKNLTKQGYKVIGSHSGVKICRWTKNE LRGKGSCYKKSLFNIASSRCMELTPSLACSSKCVFCWRHGTNPVSKNWRWEVDEPEYI LENALKGHYSMIKQMRGVPGVIAERFAKAFEVRHCALSLVGEPILYPHINKFIQLLHQ KGITSFLVCNAQHPEALRNIVKVTQLYVSIDAPTKTELKKVDRPLYKDFWERMVECLE ILKTVQNHQRTVFRLTLVKGFNMGDVSAYADLVQRGLPGFIEVKGATFSGSSDGNGNP LTMQNIPFYEECVKFVKAFTTELQRRGLHYDLAAEHAHSNCLLIADTKFKINGEWHTH IDFDKFFVLLNSGKDFTYMDYLEKTPEWALFGNGGFAPGNTRVYRKDKKKQNKENQET TTRETPLPPIPA" rep_origin 162341..162632 /note="ARS1608; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay" /db_xref="SGD:S000130196" gene complement(162632..163597) /gene="PGC1" /locus_tag="YPL206C" mRNA complement(162632..163597) /gene="PGC1" /locus_tag="YPL206C" /product="phosphatidylglycerol phospholipase" CDS complement(162632..163597) /gene="PGC1" /locus_tag="YPL206C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:18434318|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:12514182|PMID:24868093]" /experiment="EXISTENCE:direct assay:GO:0034479 phosphatidylglycerol phospholipase C activity [PMID:18434318]" /experiment="EXISTENCE:mutant phenotype:GO:0034478 phosphatidylglycerol catabolic process [PMID:18434318]" /experiment="EXISTENCE:mutant phenotype:GO:0034479 phosphatidylglycerol phospholipase C activity [PMID:18434318]" /experiment="EXISTENCE:mutant phenotype:GO:0046475 glycerophospholipid catabolic process [PMID:16172116]" /note="Phosphatidylglycerol phospholipase C; regulates phosphatidylglycerol (PG) accumulation via a phospholipase C-type degradation mechanism; PG levels affect mitochondrial function; contains glycerophosphodiester phosphodiesterase motifs" /codon_start=1 /product="phosphatidylglycerol phospholipase" /protein_id="DAA11230.1" /db_xref="SGD:S000006127" /translation="MVEIVGHRAFKARYPENTLLAFEKAYAAGADVIETDLQMTSDGM VVVNHDSDTGRMWDKNLVIGESTWEEVKRLRCKEDGSLAMMTLKEILTWAVCHPGAKL MLDIKFTNEKIIMIKTFVIMLEVKNDLKFWQERITWGLWLLDWYDFGIETGVLKDFKV IVISLSLDIASQFVKRSLTLNDPHYKLFGISVHFVSSWTSQFRLRLLPVLMKNDIKVY LWTVNKPIDFKYLCELPIHGAITDDPIKARKLCDGHTVAKKPTAEKKFVAPSLASVDG LRFHAFIKVYNILCTLLYSKWVHIKLCGWSIAYVIFLFLRTIHFL" gene 164276..165760 /gene="HRR25" /locus_tag="YPL204W" /gene_synonym="KTI14" mRNA 164276..165760 /gene="HRR25" /locus_tag="YPL204W" /gene_synonym="KTI14" /product="serine/threonine protein kinase HRR25" CDS 164276..165760 /gene="HRR25" /locus_tag="YPL204W" /gene_synonym="KTI14" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:16990132]" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:29915153]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:1495994|PMID:21532587|PMID:25569479]" /experiment="EXISTENCE:direct assay:GO:0004713 protein tyrosine kinase activity [PMID:7803855]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8034689]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:21532587]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:17461799]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8034689]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:17461799|PMID:14597664]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:14597664|PMID:17461799]" /experiment="EXISTENCE:direct assay:GO:0033551 monopolin complex [PMID:16990132]" /experiment="EXISTENCE:direct assay:GO:0042274 ribosomal small subunit biogenesis [PMID:25778921]" /experiment="EXISTENCE:direct assay:GO:0060628 regulation of ER to Golgi vesicle-mediated transport [PMID:21532587]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:25287303]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:16990132]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:1887218]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:14597664]" /experiment="EXISTENCE:mutant phenotype:GO:0033551 monopolin complex [PMID:16990132]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:18256024]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:25778921|PMID:16738661]" /experiment="EXISTENCE:mutant phenotype:GO:0051455 spindle attachment to meiosis I kinetochore [PMID:16990132]" /experiment="EXISTENCE:mutant phenotype:GO:0060628 regulation of ER to Golgi vesicle-mediated transport [PMID:21532587]" /experiment="EXISTENCE:mutant phenotype:GO:0106214 regulation of vesicle fusion with Golgi apparatus [PMID:26195667]" /experiment="EXISTENCE:mutant phenotype:GO:2000370 positive regulation of clathrin-dependent endocytosis [PMID:25287303]" /experiment="EXISTENCE:mutant phenotype:GO:2000785 regulation of autophagosome assembly [PMID:26195667]" /experiment="EXISTENCE:mutant phenotype:GO:2001159 regulation of protein localization by the Cvt pathway [PMID:25287303|PMID:24968893]" /experiment="EXISTENCE:physical interaction:GO:0033551 monopolin complex [PMID:16990132]" /note="Conserved casein kinase, monopolin subunit; regulates diverse events including vesicular traffic, DNA repair, CVT pathway, cohesion cleavage, attachment of sister kinetochores at meiosis I, exit from meiosis II, and ribosomal subunit biogenesis; binds the RNAPII CTD; phosphorylates COPII coat subunits; interacts with Sit4p phosphatase; antagonizes calcineurin signaling, reducing nuclear accumulation of Crz1p; phosphorylates Dsn1p; homolog of mammalian CK1delta" /codon_start=1 /product="serine/threonine protein kinase HRR25" /protein_id="DAA11231.1" /db_xref="SGD:S000006125" /translation="MDLRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIKLESIRS RHPQLDYESRVYRYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSF KTVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFN THRHIPYRENKSLTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKA TTKKQKYDRIMEKKLNVSVETLCSGLPLEFQEYMAYCKNLKFDEKPDYLFLARLFKDL SIKLEYHNDHLFDWTMLRYTKAMVEKQRDLLIEKGDLNANSNAASASNSTDNKSETFN KIKLLAMKKFPTHFHYYKNEDKHNPSPEEIKQQTILNNNAASSLPEELLNALDKGMEN LRQQQPQQQVQSSQPQPQPQQLQQQPNGQRPNYYPEPLLQQQQRDSQEQQQQVPMATT RATQYPPQINSNNFNTNQASVPPQMRSNPQQPPQDKPAGQSIWL" gene 166256..167398 /gene="TPK2" /locus_tag="YPL203W" /gene_synonym="PKA2" /gene_synonym="PKA3" /gene_synonym="YKR1" mRNA 166256..167398 /gene="TPK2" /locus_tag="YPL203W" /gene_synonym="PKA2" /gene_synonym="PKA3" /gene_synonym="YKR1" /product="cAMP-dependent protein kinase catalytic subunit TPK2" CDS 166256..167398 /gene="TPK2" /locus_tag="YPL203W" /gene_synonym="PKA2" /gene_synonym="PKA3" /gene_synonym="YKR1" /EC_number="2.7.11.11" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:26403272]" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:22899713]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004691 cAMP-dependent protein kinase activity [PMID:12024012]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18417610|PMID:22932476|PMID:12024012]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005952 cAMP-dependent protein kinase complex [PMID:12024012]" /experiment="EXISTENCE:genetic interaction:GO:0004691 cAMP-dependent protein kinase activity [PMID:3036373]" /experiment="EXISTENCE:genetic interaction:GO:0005952 cAMP-dependent protein kinase complex [PMID:3036373]" /experiment="EXISTENCE:genetic interaction:GO:0007265 Ras protein signal transduction [PMID:3036373]" /experiment="EXISTENCE:genetic interaction:GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly [PMID:21925385]" /experiment="EXISTENCE:genetic interaction:GO:0010737 protein kinase A signaling [PMID:20133652]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:12150916]" /experiment="EXISTENCE:mutant phenotype:GO:0070314 G1 to G0 transition [PMID:22899713]" /experiment="EXISTENCE:mutant phenotype:GO:0071333 cellular response to glucose stimulus [PMID:36167807]" /experiment="EXISTENCE:mutant phenotype:GO:2000766 negative regulation of cytoplasmic translation [PMID:22899713]" /experiment="EXISTENCE:physical interaction:GO:0005952 cAMP-dependent protein kinase complex [PMID:12024012]" /note="cAMP-dependent protein kinase catalytic subunit; promotes nutrient responsive growth via the Ras-cAMP signaling pathway; phosphorylates and inhibits histone demethylase Jhd2p in response to glucose, promoting H3K4 trimethylation and maintaining H3K14 acetylation by preventing chromatin binding of Rpd3p; required for Sfl1p-mediated pseudohyphal growth; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia" /codon_start=1 /product="cAMP-dependent protein kinase catalytic subunit TPK2" /protein_id="DAA11232.1" /db_xref="SGD:S000006124" /translation="MEFVAERAQPVGQTIQQQNVNTYGQGVLQPHHDLQQRQQQQQQR QHQQLLTSQLPQKSLVSKGKYTLHDFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLK KQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLR KSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEV QTVTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEK ILQGKVVYPPYFHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWFSEVVWERLLA KDIETPYEPPITSGIGDTSLFDQYPEEQLDYGIQGDDPYAEYFQDF" gene complement(168088..169338) /gene="AFT2" /locus_tag="YPL202C" mRNA complement(168088..169338) /gene="AFT2" /locus_tag="YPL202C" /product="Aft2p" CDS complement(168088..169338) /gene="AFT2" /locus_tag="YPL202C" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:16024809]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:27402848]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11448968]" /experiment="EXISTENCE:genetic interaction:GO:0006879 intracellular iron ion homeostasis [PMID:16024809]" /experiment="EXISTENCE:genetic interaction:GO:0010106 cellular response to iron ion starvation [PMID:16024809]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16024809]" /experiment="EXISTENCE:mutant phenotype:GO:0032048 cardiolipin metabolic process [PMID:27402848]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:27402848]" /experiment="EXISTENCE:mutant phenotype:GO:0051536 iron-sulfur cluster binding [PMID:31493153]" /experiment="EXISTENCE:mutant phenotype:GO:2000185 regulation of phosphate transmembrane transport [PMID:27618952]" /note="Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication" /codon_start=1 /product="Aft2p" /protein_id="DAA11233.1" /db_xref="SGD:S000006123" /translation="MKAKSMKSIISVPISVSKTGKMKLTASPDNLASMMSKDQNKLIH LDPVPSFEDRHEIKPWLQKIFYPQGIDIVIERSDSSKVTFKCRSVRSKVGLNPKSKGS SSRSHACPFRIRAAYSVRLQKWNVVVMNNIHSHELRFDLITKTDDYKKFKENLRQKND EKAIKTFDELEYKASLNLPLVTPIISCDCGLTKEIEAFNNIFLPLSNPPLTSKKNLLK TNKNSVSKIKSRQMDNSKPRPRLKTKLDADLHDTGFLDNFKTRNSCVKIEKEDSLTNL NEIDFTNMFCNDNFIQNYNQGLMELLTEPTPGPSSSSCILPSTPTRPLSQSKMDIALS ESTTSSPNFMETDAPYGDEIIKVSKDTKSNAPTADTDIATNLGKERNENFGMLNYNYE ALLHFNDEHFNELNSIDPALISKY" gene complement(169770..171155) /gene="YIG1" /locus_tag="YPL201C" mRNA complement(169770..171155) /gene="YIG1" /locus_tag="YPL201C" /product="Yig1p" CDS complement(169770..171155) /gene="YIG1" /locus_tag="YPL201C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16358322]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16358322]" /experiment="EXISTENCE:mutant phenotype:GO:0006114 glycerol biosynthetic process [PMID:16358322]" /note="Protein that interacts with glycerol 3-phosphatase; plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol" /codon_start=1 /product="Yig1p" /protein_id="DAA11234.1" /db_xref="SGD:S000006122" /translation="MGIPMQIYQDGKGVQFYHTRYQNVFDERASKYGNYTVNNDYPQL PDTIKEHIDQLTFSNVGEDGGDVGNYSEEDDDGDEEKELEDVFRSNRGLEFVRINNYF TTHDLQSFKSFRNFNSKYWIFYSNQAEDKKLLLYDFNGQHLIFIKQQFYGQLNLLLSD AIICMDCNFGYNSNTIQILVGFQNGKLLKLNCDLNGNVNNHLLLKDPSTSSHQSHLSI LNVWAGLLPHFVVSFSLKDGLLITSLDHQQSNGSFQSFHTNIDLPVDLRTTTNVKSVL NFPQFTLYKGNDMIFHCKNLLGSDASTLNKEINFMLKIDEDVQKIDYLLKTNHILLET NMRYLSIPTRDPIENSNSSPPVSDSEVYPIFYKTQELHVHASGTGRQIANNGKYIFIT EQHLYGTALSVYKYSISFKRWLFVGYSDIRAKYGIRSVKDLFVGNCPSVNSPVLTILT DDNNIQTILLK" gene 171484..171954 /gene="CSM4" /locus_tag="YPL200W" mRNA 171484..171954 /gene="CSM4" /locus_tag="YPL200W" /product="Csm4p" CDS 171484..171954 /gene="CSM4" /locus_tag="YPL200W" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:18585352]" /experiment="EXISTENCE:direct assay:GO:0005640 nuclear outer membrane [PMID:32059771]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12514182]" /experiment="EXISTENCE:genetic interaction:GO:0045141 meiotic telomere clustering [PMID:18585352]" /experiment="EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:21339478]" /experiment="EXISTENCE:mutant phenotype:GO:0010520 regulation of reciprocal meiotic recombination [PMID:18818742|PMID:18818741]" /experiment="EXISTENCE:mutant phenotype:GO:0034993 meiotic nuclear membrane microtubule tethering complex [PMID:32059771]" /experiment="EXISTENCE:mutant phenotype:GO:0045132 meiotic chromosome segregation [PMID:11470404]" /experiment="EXISTENCE:mutant phenotype:GO:0045141 meiotic telomere clustering [PMID:18818742|PMID:18585352]" /experiment="EXISTENCE:mutant phenotype:GO:0140444 cytoskeleton-nuclear membrane anchor activity [PMID:32059771]" /note="Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements; functions with meiosis-specific telomere-binding protein Ndj1p; CSM4 has a paralog, MPS2, that arose from the whole genome duplication" /codon_start=1 /product="Csm4p" /protein_id="DAA11235.1" /db_xref="SGD:S000006121" /translation="MMDGSITRKVTSTLSNQLATWKWKLQLSLLERKLATINNDYFLL QWELLFITNEVMKWKEMIAFLESQLFCTTQNFVAQETHDRETFQSLVDDYNKQLSENN LIISVLKSRPQLSSFPIYLSDEVCSHLKFVIAELNSLIIVFFISLVFLWVSIEV" gene complement(172033..172755) /locus_tag="YPL199C" mRNA complement(172033..172755) /locus_tag="YPL199C" /product="Smr domain-containing protein" CDS complement(172033..172755) /locus_tag="YPL199C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:32234470]" /note="Protein involved in nonstop mRNA decay; predicted to be palmitoylated" /codon_start=1 /product="Smr domain-containing protein" /protein_id="DAA11236.1" /db_xref="SGD:S000006120" /translation="MKGTGGVVVGTQNPVRDYNHSTDEEYQRLRRLADEAYKKRDQLS HESQTAYQQGDKKLAHELSEKSKAQLKTAEDFNMQAAEYVFVENNADSSSNEIDLHGL YVKEALFILQKRIKFAIDHNEPQLNVIVGKGLHSQNGIAKLKPSIEEFCAKHGIRNHL EKGNSGVLVLELQGVQMQMDGPAVNAPTNQYNAQPHPQYNNNGGQPQGQAQNYNNSGN DNKDSTLTSIFKIFCNCIQSLA" gene 173152..174702 /gene="RPL7B" /locus_tag="YPL198W" mRNA join(173152..173162,173572..173665,174073..174702) /gene="RPL7B" /locus_tag="YPL198W" /product="ribosomal 60S subunit protein L7B" CDS join(173152..173162,173572..173665,174073..174702) /gene="RPL7B" /locus_tag="YPL198W" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:23874617]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:23874617]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:19466602]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19466602]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:23874617]" /experiment="EXISTENCE:direct assay:GO:0042273 ribosomal large subunit biogenesis [PMID:23945946]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:22893726]" /note="Ribosomal 60S subunit protein L7B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication" /codon_start=1 /product="ribosomal 60S subunit protein L7B" /protein_id="DAA11237.1" /db_xref="SGD:S000006119" /translation="MSTEKILTPESQLKKTKAQQKTAEQIAAERAARKAANKEKRAII LERNAAYQKEYETAERNIIQAKRDAKAAGSYYVEAQHKLVFVVRIKGINKIPPKPRKV LQLLRLTRINSGTFVKVTKATLELLKLIEPYVAYGYPSYSTIRQLVYKRGFGKINKQR VPLSDNAIIEANLGKYGILSIDDLIHEIITVGPHFKQANNFLWPFKLSNPSGGWGVPR KFKHFIQGGSFGNREEFINKLVKAMN" gene 173827..173904 /gene="SNR59" /locus_tag="YNCP0003W" ncRNA 173827..173904 /ncRNA_class="snoRNA" /gene="SNR59" /locus_tag="YNCP0003W" /product="SNR59" /experiment="EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]" /experiment="EXISTENCE:curator inference:GO:0031428 box C/D methylation guide snoRNP complex [PMID:10024243]" /note="C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position A807" /db_xref="SGD:S000006450" gene 175043..175864 /gene="OXR1" /locus_tag="YPL196W" mRNA 175043..175864 /gene="OXR1" /locus_tag="YPL196W" /product="Oxr1p" CDS 175043..175864 /gene="OXR1" /locus_tag="YPL196W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:38565737]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15060142]" /experiment="EXISTENCE:direct assay:GO:0010849 regulation of proton-transporting ATPase activity, rotational mechanism [PMID:34918374]" /experiment="EXISTENCE:direct assay:GO:0032984 protein-containing complex disassembly [PMID:34918374]" /experiment="EXISTENCE:mutant phenotype:GO:0010849 regulation of proton-transporting ATPase activity, rotational mechanism [PMID:38565737]" /experiment="EXISTENCE:mutant phenotype:GO:0032984 protein-containing complex disassembly [PMID:38565737]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:38589611]" /note="Protein that regulates the vacuolar V-ATPase; inhibits V1-ATPase activity and triggers ATP-dependent disassembly of the V-ATPase holoenzyme, counteracting the function of the RAVE complex; localizes to the cytoplasm; required for retention of the vacuolar-ATPase V0 domain subunit Stv1p in pre-vacuolar compartments; involved in resistance to oxidative damage; member of a conserved family of TLDc domain proteins found in eukaryotes; contains an N-terminal EF-hand-like domain" /codon_start=1 /product="Oxr1p" /protein_id="DAA11238.1" /db_xref="SGD:S000006117" /translation="MFGVKDAIFKIKRSIAGTDSSDSTAYTTASESSPQLKDSHNPFR NKTTSERTIVEEGSLPPVRLNGYLPSTKNKLLTPEMCDEIRTLMPTRIQLYTEWNLLY SLEQHGSSLHSLYSNVAPDSKEFRRVGYVLVIKDRKNGIFGAYSNEAFHPNEHRQYTG NGECFLWKLDKVPDVNISEKEESEQEGKEGKEEGDKEERWRFSGYPYTGVNEFAIYCT SEFLSMGAGDGHYGLLCDDGLLHGVSNPCQTYGNEVLSKEGKKFSIVALEVWRVG" gene 176223..179021 /gene="APL5" /locus_tag="YPL195W" /gene_synonym="YKS4" mRNA 176223..179021 /gene="APL5" /locus_tag="YPL195W" /gene_synonym="YKS4" /product="Apl5p" CDS 176223..179021 /gene="APL5" /locus_tag="YPL195W" /gene_synonym="YKS4" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:17895371]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:9335339]" /experiment="EXISTENCE:mutant phenotype:GO:0030123 AP-3 adaptor complex [PMID:9250663]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:10559961]" /note="Delta adaptin-like subunit of the clathrin associated protein complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; suppressor of loss of casein kinase 1 function; the clathrin associated protein complex is also known as AP-3" /codon_start=1 /product="Apl5p" /protein_id="DAA11239.1" /db_xref="SGD:S000006116" /translation="MTSLYAPGAEDIRQRLRPFGFFFEKSLKDLIKGIRSHNETPEKL DQFFKQVLSECREEVNSPDLNSKTNAVLKLTYLEMYGFDMAWCNFHILEVMSSNKLQQ KRVGYLAASQSFYKDSDILMLATNLLKKDLKYDGNNDVVKVGIALSGLSTIITPSLAR DIADDLFTMLNSTRPYIRKKAITALFKVFLQYPEALRDNFDKFVSKLDDDDISVVSAA VSVICELSKKNPQPFIQLSPLLYEILVTIDNNWIIIRLLKLFTNLSQVEPKLRAKLLP KILELMESTVATSVIYESVNCIVKGNMLEEDDFETAMACLERLHTFCDSQDPNLRYIS CILFYKIGKINTDFISRFDQLIIRLLSDVDVSIRSKAIELVEGIVDEDNLKAIVQTLM KQFVDEDVVILQTGSIVYEKSKRIPIIIPENYKIKMVNVIISICSADNYSSVNDFEWY NAVIMDLAMLCQDISDKSLGSKIGEQFRNLMIKVPSMREVTIANIIKLISNDNINKQL PTVLRECIWCLGEFSTLVENGNDLIKIMTENISYYSHSVQEVLILALVKVFSNWCNNF QEDKRFEIKMVLKELIEFFENLSYSSTFEVQERSVEVLEFLRLSLEALEEDTEGLPML LSEVLPSFFNAYELAPIARGTQLKLAVDENLDLETPFLTKEAADELLDEQKSDAISDL MSDISMDEQVELKFVDDSDTSYEEKEKLDDFENPFEIEREKERMSNPYYLGEEDEERT KNSKDLLDLNEEESSDKKPETIRLNRTDNSLNSLSLSTTEISRKKKKGKKKNRVQVLS DEPVIEAAPKRKDAFQKPHDNHSTQNPLKKDKINLRMHSQLENFDFSNFGQSSNAGRG SQEEGNLRKEDELELSRLEANLIVKDEKDNLSDTEEVIVIKKKKKGKKSKSKNKLKTK AKNSPEPNEFLRDQSTDI" gene 179277..181115 /gene="DDC1" /locus_tag="YPL194W" mRNA 179277..181115 /gene="DDC1" /locus_tag="YPL194W" /product="Ddc1p" CDS 179277..181115 /gene="DDC1" /locus_tag="YPL194W" /experiment="EXISTENCE:direct assay:GO:0000725 recombinational repair [PMID:16840526]" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:11825877]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0030295 protein kinase activator activity [PMID:31340146]" /experiment="EXISTENCE:direct assay:GO:0030896 checkpoint clamp complex [PMID:9891048|PMID:12604797|PMID:9670034]" /experiment="EXISTENCE:genetic interaction:GO:0000725 recombinational repair [PMID:16840526]" /experiment="EXISTENCE:mutant phenotype:GO:0007095 mitotic G2 DNA damage checkpoint signaling [PMID:9311982]" /experiment="EXISTENCE:mutant phenotype:GO:0031571 mitotic G1 DNA damage checkpoint signaling [PMID:9311982]" /experiment="EXISTENCE:mutant phenotype:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:9311982]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:11825877]" /experiment="EXISTENCE:mutant phenotype:GO:0051598 meiotic recombination checkpoint signaling [PMID:11825877]" /note="DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress" /codon_start=1 /product="Ddc1p" /protein_id="DAA11240.1" /db_xref="SGD:S000006115" /translation="MSFKATITESGKQNIWFRAIYVLSTIQDDIKITVTTNELIAWSM NETDTTLCQVRFQKSFFEEYEFKPHEIVFGENGVQVIEDTYGNSHKLYSFRVNGRHLT TISRKPDGDGIKSFTIAVNNTSTCPESLANRLIVVIEMDSLIVKEYCPQFQPIKYDPI IINLKYKRRFLDVFGTAASDRNPQEPLDPKLLDVFTNTERELTSALFNEEVESDIRKR NQLTAADEINYICCNSTLLKNFLDNCNVNVTDEVKLEINVHRLSITAFTKAVYGKNND LLRNALSMSNTISTLDLEHYCLFTTIEDEKQDKRSHSKRREHMKSIIFKLKDFKNFIT IGPSWKTTQDGNDNISLWFCHPGDPILMQMQKPGVKLELVEVTDSNINDDILEGKFIK TAISGSKEEAGLKDNKESCESPLKSKTALKRENLPHSVAGTRNSPLKVSYLTPDNGST VAKTYRNNTARKLFVEEQSQSTNYEQDKRFRQASSVHMNMNREQSFDIGTTHEVACPR NESNSLKRSIADICNETEDPTQQSTFAKRADTTVTWGKALPAADDEVSCSNIDRKGML KKEKLKHMQGLLNSQNDTSNHKKQDNKEMEDGLGLTQVEKPRGIFD" gene 181403..182548 /gene="RSA1" /locus_tag="YPL193W" mRNA 181403..182548 /gene="RSA1" /locus_tag="YPL193W" /product="Rsa1p" CDS 181403..182548 /gene="RSA1" /locus_tag="YPL193W" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:10567587]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:10567587]" /experiment="EXISTENCE:mutant phenotype:GO:0000492 box C/D snoRNP assembly [PMID:25170085]" /note="Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly" /codon_start=1 /product="Rsa1p" /protein_id="DAA11241.1" /db_xref="SGD:S000006114" /translation="MNYNNFENSKGDGHSRLPKPTYSGTLSDGYDESKIKRQKTDSAF NAAYSPHMYPNSPYYEGSWNTGYTPQLHHVAPHNQYFHPIQPSTQYNYTSPPNYTENY IPPVHQNISYAPALNLQKWPSSYCENTQALKNDKDYQTSISYEDVAIPTVKEIQLIEK NRGKDTFMNEISPVPSSKDQASAEPTEIPRKDPELANSNAEDDHNNLGLEDDDRDEQL ESEGLGKVVLVPGTSIALITDEDVKKWREERKKMWLLKISNNKQKHMQEMGIKEDELK SQPSIFKESRKEKQFIQSIQNQVQRGNPKIDLNLKLIQREFANENSQLLDFIRELGDV GLLEYELSQQEKDVLFGSSEDNNKNHYKPNYKNRKPNLSRANFTRNK" gene complement(182655..183056) /gene="PRM3" /locus_tag="YPL192C" mRNA complement(182655..183056) /gene="PRM3" /locus_tag="YPL192C" /product="pheromone-regulated protein PRM3" CDS complement(182655..183056) /gene="PRM3" /locus_tag="YPL192C" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:12514182]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:19297527]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:12514182|PMID:19297527]" /experiment="EXISTENCE:mutant phenotype:GO:0005635 nuclear envelope [PMID:12514182]" /experiment="EXISTENCE:mutant phenotype:GO:0048288 nuclear membrane fusion involved in karyogamy [PMID:19297527]" /note="Protein required for nuclear envelope fusion during karyogamy; pheromone-regulated; peripheral protein of the nuclear membrane; interacts with Kar5p at the spindle pole body" /codon_start=1 /product="pheromone-regulated protein PRM3" /protein_id="DAA11242.1" /db_xref="SGD:S000006113" /translation="MTAMKEDNAALITLKKNNDQEKLRVHKLTDASSNSADGFVINKA KNGGPLNKKSLVNNEQHIKKAVSPGRVRKHKTTTSSTKSRTKSKKKDASESKVQRENK GSFYQGAIFGSFLGAAVTTVLSNLAVKALQN" gene complement(183597..184679) /gene="MIY2" /locus_tag="YPL191C" /gene_synonym="MIY1" mRNA complement(183597..184679) /gene="MIY2" /locus_tag="YPL191C" /gene_synonym="MIY1" /product="ubiquitinyl hydrolase 1" CDS complement(183597..184679) /gene="MIY2" /locus_tag="YPL191C" /gene_synonym="MIY1" /EC_number="3.4.19.12" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071108 protein K48-linked deubiquitination [PMID:27292798]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:1990380 K48-linked deubiquitinase activity [PMID:27292798]" /note="K48-specific deubiquitinating (DUB) enzyme; MINDY family endo-type deubiquitinase that preferentially cleaves long K48-linked polyubiquitin chains between moieties; diploid deletion strain exhibits high budding index; GFP-fusion protein localizes to the cytoplasm endoplasmic reticulum and cell periphery in high-throughput studies; YPL191C has a paralog, YGL082W, that arose from the whole genome duplication; ortholog of human MINDY2/FAM63B" /codon_start=1 /product="ubiquitinyl hydrolase 1" /protein_id="DAA11243.1" /db_xref="SGD:S000006112" /translation="MDLSFTTKSVKINGQNHRILLQNENGPCALLALANILILSPDHT RFSNELIRLVNKGSQISLKELIEVLADIALQVTDKPSTDISELLSLLPRLHEGLNINP EFNGSFENTKEMSIFRLFNVDVVHGWVINSFINENIDEKLSHYSYESAQRILTQAADI NCGISQDENSDEVLRDAMHLGLFLNESPTQLTAFGLLRLREKLLHNKFSILFRNDHFS TLFKYEDRLYTLVTDFGYKNCKDIVWQSLDSVDGSCDAFFAGNFSAAEVNGQQLSTDI ERDFGTGNLLLEEIQQIENDKELAKQLQEQEQERVTKFEAKRKIHSHKKNSEIHAPVK KDKFKRRSSLLNAKASEKEKSECVVM" gene complement(185317..187725) /gene="NAB3" /locus_tag="YPL190C" /gene_synonym="HMD1" mRNA complement(185317..187725) /gene="NAB3" /locus_tag="YPL190C" /gene_synonym="HMD1" /product="Nab3p" CDS complement(185317..187725) /gene="NAB3" /locus_tag="YPL190C" /gene_synonym="HMD1" /experiment="EXISTENCE:direct assay:GO:0001068 transcription regulatory region RNA binding [PMID:21084293]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:20805243|PMID:31960028]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7962083]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0030847 termination of RNA polymerase II transcription, exosome-dependent [PMID:16427013]" /experiment="EXISTENCE:direct assay:GO:0035649 Nrd1 complex [PMID:10655211]" /experiment="EXISTENCE:direct assay:GO:0071041 antisense RNA transcript catabolic process [PMID:27190003]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:11565036]" /experiment="EXISTENCE:mutant phenotype:GO:0031126 sno(s)RNA 3'-end processing [PMID:11565036]" /experiment="EXISTENCE:mutant phenotype:GO:0034472 snRNA 3'-end processing [PMID:11565036]" /experiment="EXISTENCE:mutant phenotype:GO:0042780 tRNA 3'-end processing [PMID:21460797]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:21113025]" /experiment="EXISTENCE:mutant phenotype:GO:0071034 CUT catabolic process [PMID:16973436]" /experiment="EXISTENCE:mutant phenotype:GO:0071041 antisense RNA transcript catabolic process [PMID:22028667]" /note="RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing; Nrd1-Nab3 pathway appears to have a role in rapid suppression of some genes when cells are shifted to poor growth conditions, indicating role for Nrd1-Nab3 in regulating cellular response to nutrient availability" /codon_start=1 /product="Nab3p" /protein_id="DAA11244.1" /db_xref="SGD:S000006111" /translation="MSDENHNSDVQDIPSPELSVDSNSNENELMNNSSADDGIEFDAP EEEREAEREEENEEQHELEDVNDEEEEDKEEKGEENGEVINTEEEEEEEHQQKGGNDD DDDDNEEEEEEEEDDDDDDDDDDDDEEEEEEEEEEGNDNSSVGSDSAAEDGEDEEDKK DKTKDKEVELRRETLEKEQKDVDEAIKKITREENDNTHFPTNMENVNYDLLQKQVKYI MDSNMLNLPQFQHLPQEEKMSAILAMLNSNSDTALSVPPHDSTISTTASASATSGARS NDQRKPPLSDAQRRMRFPRADLSKPITEEEHDRYAAYLHGENKITEMHNIPPKSRLFI GNLPLKNVSKEDLFRIFSPYGHIMQINIKNAFGFIQFDNPQSVRDAIECESQEMNFGK KLILEVSSSNARPQFDHGDHGTNSSSTFISSAKRPFQTESGDMYNDDNGAGYKKSRRH TVSCNIFVKRTADRTYAIEVFNRFRDGTGLETDMIFLKPRMELGKLINDAAYNGVWGV VLVNKTHNVDVQTFYKGSQGETKFDEYISISADDAVAIFNNIKNNRNNSRPTDYRAMS HQQNIYGAPPLPVPNGPAVGPPPQTNYYQGYSMPPPQQQQQQPYGNYGMPPPSHDQGY GSQPPIPMNQSYGRYQTSIPPPPPQQQIPQGYGRYQAGPPPQPPSQTPMDQQQLLSAI QNLPPNVVSNLLSMAQQQQQQPHAQQQLVGLIQSMQGQAPQQQQQQLGGYSSMNSSSP PPMSTNYNGQNISAKPSAPPMSHQPPPPQQQQQQQQQQQQQQQQPAGNNVQSLLDSLA KLQK" gene complement(188307..188513) /gene="COA2" /locus_tag="YPL189C-A" mRNA complement(188307..188513) /gene="COA2" /locus_tag="YPL189C-A" /product="Coa2p" CDS complement(188307..188513) /gene="COA2" /locus_tag="YPL189C-A" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:18541668]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:18541668]" /experiment="EXISTENCE:physical interaction:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:18541668]" /note="Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p" /codon_start=1 /product="Coa2p" /protein_id="DAA11245.1" /db_xref="SGD:S000028527" /translation="MRAVTRNKIVNNLYFSTFLIAFASVAIGSVLPCPAHSVDSDSPA VQQHKLQLAHEQELKRKDALSKKI" gene 189154..190983 /gene="GUP2" /locus_tag="YPL189W" mRNA 189154..190983 /gene="GUP2" /locus_tag="YPL189W" /product="putative O-acyltransferase" CDS 189154..190983 /gene="GUP2" /locus_tag="YPL189W" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015793 glycerol transmembrane transport [PMID:10931309]" /experiment="EXISTENCE:genetic interaction:GO:0071475 cellular hyperosmotic salinity response [PMID:10931309]" /note="Probable membrane protein; possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; homolog of the mammalian Hedgehog pathway modulator HHAT; GUP2 has a paralog, GUP1, that arose from the whole genome duplication" /codon_start=1 /product="putative O-acyltransferase" /protein_id="DAA11246.1" /db_xref="SGD:S000006110" /translation="MSMLRIWSCIVHFFSVQALDSRIKPDIEFKRRQRIFINSSKEEN GSSSSAVTVTRNPVLSSNSPSPPLWNTWEFRLYYLAFTVVVPFMIKAALATSSESNPN YYKFSGLLAHGWILGRKVDNSDPQYRFFRSNFFLLAILILLQIILKKVFVKFSKIPKT KFDFACGLVFVCFMYGINSVKLFTHAFIFFTLAHSLKRKRLIAAFAIWSYGIFTLFIN QKMKNLPFNNIAIILSPMDQWYKGIVPRWDFFFNFTLLRLLSYSMDFLERWHEQLSRQ PSIDYDDRRPEFRKSLSGSTLQTIYESGKNVLEEKERLVAEHHIQDYNFINFIAYITY APLFLVGPIITFNDYLYQSENKLPSLTKKNIGFYALKVFSSLLLMEIILHYIYVGAIA RTKAWNNDTPLQQAMIALFNLNIMYLKLLIPWRLFRLWAMVDGIDAPENMLRCVDNNY STVGFWRAWHTSFNKWVIRYIYVPFGGSNNKILTSFAVFSFVAIWHDIQLRVLFWGWL TVLLLLGETYITNCFSRYRFRSWYRFVCGIGAAINICMMMIINVYGFCLGAEGTKLLL KGIFNNSHSPEFLTAVMVSLFIAVQVMFEIREEEKRHGINLKC" gene 191406..192650 /gene="POS5" /locus_tag="YPL188W" mRNA 191406..192650 /gene="POS5" /locus_tag="YPL188W" /product="NADH kinase" CDS 191406..192650 /gene="POS5" /locus_tag="YPL188W" /EC_number="2.7.1.86" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:12727869]" /experiment="EXISTENCE:direct assay:GO:0006741 NADP biosynthetic process [PMID:12727869]" /experiment="EXISTENCE:direct assay:GO:0042736 NADH kinase activity [PMID:12727869]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:20889970]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:7586028]" /note="Mitochondrial NADH kinase; phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress" /codon_start=1 /product="NADH kinase" /protein_id="DAA11247.1" /db_xref="SGD:S000006109" /translation="MFVRVKLNKPVKWYRFYSTLDSHSLKLQSGSKFVKIKPVNNLRS SSSADFVSPPNSKLQSLIWQNPLQNVYITKKPWTPSTREAMVEFITHLHESYPEVNVI VQPDVAEEISQDFKSPLENDPNRPHILYTGPEQDIVNRTDLLVTLGGDGTILHGVSMF GNTQVPPVLAFALGTLGFLSPFDFKEHKKVFQEVISSRAKCLHRTRLECHLKKKDSNS SIVTHAMNDIFLHRGNSPHLTNLDIFIDGEFLTRTTADGVALATPTGSTAYSLSAGGS IVSPLVPAILMTPICPRSLSFRPLILPHSSHIRIKIGSKLNQKPVNSVVKLSVDGIPQ QDLDVGDEIYVINEVGTIYIDGTQLPTTRKTENDFNNSKKPKRSGIYCVAKTENDWIR GINELLGFNSSFRLTKRQTDND" gene 193648..194145 /gene="MF(ALPHA)1" /locus_tag="YPL187W" mRNA 193648..194145 /gene="MF(ALPHA)1" /locus_tag="YPL187W" /product="Mf(Alpha)1p" CDS 193648..194145 /gene="MF(ALPHA)1" /locus_tag="YPL187W" /experiment="EXISTENCE:direct assay:GO:0000772 mating pheromone activity [PMID:6306574]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:776628]" /experiment="EXISTENCE:direct assay:GO:1903135 cupric ion binding [PMID:27476515]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:3887136]" /experiment="EXISTENCE:mutant phenotype:GO:0000772 mating pheromone activity [PMID:3887136]" /note="Alpha-factor mating pheromone made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor; binds copper(II) ions" /codon_start=1 /product="Mf(Alpha)1p" /protein_id="DAA11248.1" /db_xref="SGD:S000006108" /translation="MRFPSIFTAVLFAASSALAAPVNTTTEDETAQIPAEAVIGYLDL EGDFDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLDKREAEAWHWLQLKPGQPMY KREAEAEAWHWLQLKPGQPMYKREADAEAWHWLQLKPGQPMYKREADAEAWHWLQLKP GQPMY" gene complement(194512..195426) /gene="UIP4" /locus_tag="YPL186C" mRNA complement(194512..195426) /gene="UIP4" /locus_tag="YPL186C" /product="Uip4p" CDS complement(194512..195426) /gene="UIP4" /locus_tag="YPL186C" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:11056382]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11056382|PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006998 nuclear envelope organization [PMID:35171083]" /note="Protein required for nuclear envelope integrity; involved in distribution of nuclear pore complexes; interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope" /codon_start=1 /product="Uip4p" /protein_id="DAA11249.1" /db_xref="SGD:S000006107" /translation="MVTIVFDHPAEDFPELKIAGEFTNWEGVPMKINTSSGKWEYKFD ESSVTKHNDKDKVHFKFIDQNGNWFADDEYPKEVDEHSNENNVATLNNEEDGGSAGEE KDEGDKTAHNTNENGSELYYEGPETPTPSLKGNVTFPSPKTAISQDGSAFAKETTRKE RKYEHAPLNEVPVERDPKEENKELSPNFSQEQTENKQDKGLDNLSEGNDNDNTRVNED TDVTDTQESEHEINGSDTENTDMSEQEEIQKIDKPADQNAKSIVKEGDANTEDYESVL KKLLGALGRFFGSWFSWLTTKMSSSEAS" gene complement(195950..197788) /gene="MRN1" /locus_tag="YPL184C" /gene_synonym="PTR69" mRNA complement(195950..197788) /gene="MRN1" /locus_tag="YPL184C" /gene_synonym="PTR69" /product="Mrn1p" CDS complement(195950..197788) /gene="MRN1" /locus_tag="YPL184C" /gene_synonym="PTR69" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003730 mRNA 3'-UTR binding [PMID:36862555]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23028530]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:23028530]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:genetic interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:23028530]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:23028530]" /experiment="EXISTENCE:genetic interaction:GO:0061158 3'-UTR-mediated mRNA destabilization [PMID:36862555]" /experiment="EXISTENCE:genetic interaction:GO:1990394 cellular response to cell wall damage [PMID:36862555]" /experiment="EXISTENCE:mutant phenotype:GO:0061158 3'-UTR-mediated mRNA destabilization [PMID:36862555]" /experiment="EXISTENCE:mutant phenotype:GO:1990394 cellular response to cell wall damage [PMID:36862555]" /note="mRNA-binding protein; binds to the 3'UTR of cell wall-related mRNAs and destabilizes these mRNAs during stress, acting antagonistically to Nab6p; links cell wall homeostasis to mitochondrial structure and function; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation" /codon_start=1 /product="Mrn1p" /protein_id="DAA11250.1" /db_xref="SGD:S000006105" /translation="MVVSYNNNNNNNNNNNNNNISNNNNNNNMFPPFPSSDDFAMYQQ SSSSGPYQETYASGPQNFGDAVYPMNGNFTLLPSDFTREPNDSFFYENDGIFDYQRIQ QQPTQFQTKQRNDSQQQRFSQEQNFEIDNEVVHNNNRYYEYERSSNEVSPFDDENPNV LSDGMSPTIMATATAVTNANAPLPVNAQANNPLNFTSAPSRTVYLGNVPPNLSVKELL DHVRSGVVEDVKIIPEKMCAFVSFIDESAALLFHSDAILKRLNIGDRDIKIGWGKPTR IDPIVAARISTDGATRNVYIGRMTIEGEESHLSEEQLRVDLEEYGEIDCIKIIKEKGI AFIHFASILNAIKVVTNLPIRNPYYQNKRIFYGKDRCAFITKTQQHNAAQFLGVQPGM EHMIEFSDREFISNALLQQSAAAAAIATSAGGPNNLGNRTVYLGSLPKDVKIEEICNA VRGGLLQSIKLLNDRYVCFVTFIDPTAAAQFYAMSSLYGFTVQKKRCKVGWGKHSGPL PNALALAVSNGASRNVYVGNIDFVGDSLRDERVFTESNLRHIFQQYGEVEQINFLPEK NCCFINYTNISNAILALDKIKSNPYFKDLKINFGKDRCGNVPHQSR" gene 199095..199376 /gene="RTC6" /locus_tag="YPL183W-A" /gene_synonym="bL36m" /gene_synonym="TAE4" mRNA 199095..199376 /gene="RTC6" /locus_tag="YPL183W-A" /gene_synonym="bL36m" /gene_synonym="TAE4" /product="putative mitochondrial 54S ribosomal protein RTC6" CDS 199095..199376 /gene="RTC6" /locus_tag="YPL183W-A" /gene_synonym="bL36m" /gene_synonym="TAE4" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:38493895]" /experiment="EXISTENCE:genetic interaction:GO:0042254 ribosome biogenesis [PMID:20691087]" /experiment="EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:20691087]" /note="Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="mitochondrial 54S ribosomal protein bL36m RTC6" /protein_id="DAA11251.1" /db_xref="SGD:S000007224" /translation="MFLQTLRLTMPRMFLHMKPSPITITRACTVPSLLSVAAPQPALV AANRPLVFNRGFKVRTSVKKFCSDCYLVRRKGRVYIYCKSNKKHKQRQG" gene complement(199495..202536) /gene="RTT10" /locus_tag="YPL183C" /gene_synonym="ERE2" /gene_synonym="TRM734" mRNA complement(199495..202536) /gene="RTT10" /locus_tag="YPL183C" /gene_synonym="ERE2" /gene_synonym="TRM734" /product="Rtt10p" CDS complement(199495..202536) /gene="RTT10" /locus_tag="YPL183C" /gene_synonym="ERE2" /gene_synonym="TRM734" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:21880895]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:21880895]" /experiment="EXISTENCE:mutant phenotype:GO:0002130 wobble position ribose methylation [PMID:22912484]" /experiment="EXISTENCE:mutant phenotype:GO:0032456 endocytic recycling [PMID:21880895]" /experiment="EXISTENCE:physical interaction:GO:0002130 wobble position ribose methylation [PMID:22912484]" /note="WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6" /codon_start=1 /product="tRNA (34-2'-O)-methyltransferase regulator RTT10" /protein_id="DAA11252.1" /db_xref="SGD:S000006104" /translation="MKDLSHYGPALCVKFYNDYVLAGYGPFIHVYDYHSATLINKCRL FHYNKVHGLSLSSEGKILAYGARSVTIVELEDVLKKESLVDFERINSDWITGATFSFD NLQIYLLTCYNKVLICDLNCEVLFRKSLGGERSILYSGIIKVFGPDKVYVNAGTVMGG VIIWDLFSETKIHNLLGHEGSIFYVNLSNNGRYVASCSDDRSIRLWDLETGKQLSVGW SHTARIWNLMFFDNDSKLISVSEDCTCRVWNIIESRENVAELSISNVYEVHLIKSIWG VDVKDDEMIAVTSGNDGRLKLIDLLQLKRHGDEETSFSLDDIAKQCGDIFEKNESIKG FQWFSFGVIAITSLGKILKYSDVTKQWKLLLTNEKFNSYPITNGIQTQNIAVFSNNKS DILLIKFSKDSADIIETEEFHLDELSKTNNCLVTEYDDDSFLLTLQSPNPREKFVCLE ISLQNLKIKSKHCFNKPENFSSSCLTSFRNHILVGSRFSTLVIYNLLDESEEPFIIRR LSPGDTTTSIEFVEDKDNSAVFSVTNRDGYYVFIELTKNSLEEGPYRLSYKVLHSNKM MKGFLEGAFFNSKGEYITYGFKSSLFYLYNETNCYELASEVCGGSHRLWNLAKITDGH VLMYIKASRFHLRKIYNSIVPETLENGVHGREIRDISICPVSNTNTNDNFKDGHIFCT ASEDTTIKLGYFNNRTGKVQNFWTQRKHVSGLQRCQFINHKLMISSSAREELFLWELN DKYNKRPYMTIRQALPVSTNNSDLRIMDFDVKFISQSGDFLLVTVYSDSTIKIWHYRE NQNKFDLIMQGRYKTCCLFNVVFIALKEELLVVISPTDGHLVVYNITEYVPFSVDPIS GDLVDHKLDATISNLPAPVAQLPVHQSGVKSLDYVANATRTSATILTGGDDNGLGLSN LKLDDSNKVTLKTSDFIAAAASSTITSGMLINGGKEVITTSVDQVIRAWEITAGKLSL VDKKRTTVADTGSLEIISNDEDADSEKTLLIGGVGLSIWKK" gene 203421..204941 /gene="CTI6" /locus_tag="YPL181W" /gene_synonym="RXT1" mRNA 203421..204941 /gene="CTI6" /locus_tag="YPL181W" /gene_synonym="RXT1" /product="Cti6p" CDS 203421..204941 /gene="CTI6" /locus_tag="YPL181W" /gene_synonym="RXT1" /experiment="EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:19040720|PMID:16286007|PMID:16314178|PMID:16286008]" /experiment="EXISTENCE:direct assay:GO:0035064 methylated histone binding [PMID:17142463]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:19417103]" /experiment="EXISTENCE:mutant phenotype:GO:0045893 positive regulation of DNA-templated transcription [PMID:12086626]" /experiment="EXISTENCE:mutant phenotype:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:16286008]" /experiment="EXISTENCE:mutant phenotype:GO:0061188 negative regulation of rDNA heterochromatin formation [PMID:16286008]" /note="Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain" /codon_start=1 /product="Cti6p" /protein_id="DAA11253.1" /db_xref="SGD:S000006102" /translation="MESTAIVPKGPVVGSEDMEKAEVIASGSTDIISTTSTATTTAAI GSVQEESVKQEDVPMEGGEGEVEEEEGETRCICGELDTPDDSGFFIQCEQCSSWQHGY CVSITQDNAPDKYWCEQCRPELHQLFTTDTGEARSIYKPVQEKRRQSRRKARSAAASK SHAANEAEKSPRNTSNTDDNVDDIGDEEDEVEDEASAVALAKDGNTRSSRRRRRNSMD DASTDQYSLDPGDSDKKLLDRKRATFMAREEKQYQRMLEKALKESRRTSHQEDPESYE NDADIYQGDTDNHNGTTRLQTDVMLTEGKPDSVTNDDMKESLRPSKEQSMEKTNDVEK EASQEKESSTGSAQDTEKTDEPILPLTSISSSEDDSRKASSRGSKRVSKPARKGNRTR RSNTSSDTNQNRRSADIGTDKPVKPRLPPQRTSLNEMRRRVSAILEFISRTQWELSED QSDREEFVRFVENQHFVEKVDTIYNGYNESLSMMDDLTRELLLWEKKYSNNTNAIQ" gene 205248..207647 /gene="TCO89" /locus_tag="YPL180W" mRNA 205248..207647 /gene="TCO89" /locus_tag="YPL180W" /product="Tco89p" CDS 205248..207647 /gene="TCO89" /locus_tag="YPL180W" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095|PMID:19748353|PMID:26928762|PMID:17560372]" /experiment="EXISTENCE:mutant phenotype:GO:0006071 glycerol metabolic process [PMID:10931309]" /experiment="EXISTENCE:mutant phenotype:GO:0009651 response to salt stress [PMID:17298473]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:14736892]" /experiment="EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:14736892]" /experiment="EXISTENCE:physical interaction:GO:0031931 TORC1 complex [PMID:14736892]" /note="Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p); regulates global H3K56ac; TORC1 complex regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin" /codon_start=1 /product="Tco89p" /protein_id="DAA11254.1" /db_xref="SGD:S000006101" /translation="MVHRGRTLKSDTDVTSLNASTVSHQSKPFRQFSTRSRAKSNASF KGLRRVLTHDGTLDNDYFNKHNVSQKCKSSDALFRKRTISGLNMTALTRVKSNQGKRS ASFHSPVHNTLLSPKNSSHSNTGTAGFGLKPRRSKSTQSVLSLRDAQESKKSESTTDE EVECFSEDNIEDGKVNNDKVIAEHVMPEEKKNVQQLNQNELQSPDSIDEQEEDKSGTD GKENHRAVSLPLPHLSSNNYFGESSHSIEHQKDGETSPSSIETKLNATSVINEEGQSK VTKEADIDDLSSHSQNLRASLVKAGDNISEAPYDKEKKILDVGNTLAAHKSNQKPSHS DEQFDQEDHIDAPRSNSSRKSDSSFMSLRRQSSKQHKLLNEEEDLIKPDDISSAGTKD IEGHSLLENYAPNMILSQSTGVERRFENSSSIQNSLGNEIHDSGEHMASGDTFNELDD GKLRKSKKNGGRSQLGQNIPNSQSTFPTIANIGSKDNNVPQHNFSTSISSLTNNLRRA APESFHGSRMNNIFHKKGNQNLLLRSNDLNKNSAAPASPLSNEHITSSTNSGSDANRQ SNSGAKFNSFAQFLKSDGIDAESRTQRKLWLQRENSIMDLSSQNDGSDSIFMAGNIDA KREFERISHEYSNVKRFYNPLDEALLRVQPIITGNANNIRKKSHNDAQSIAHSSSDTD HKDEDDLLFTNYDKKFDDLYPHLASAKIQAVLSGIWKSESYLFNKDVNPINKNRTTST NHSVGHTASQNARNLLRGPMGSSTTLHHQRVINSLQPTTRAVNRRMENVGYMHTQPQQ R" gene 208157..209806 /gene="PPQ1" /locus_tag="YPL179W" /gene_synonym="SAL6" mRNA 208157..209806 /gene="PPQ1" /locus_tag="YPL179W" /gene_synonym="SAL6" /product="protein-serine/threonine phosphatase" CDS 208157..209806 /gene="PPQ1" /locus_tag="YPL179W" /gene_synonym="SAL6" /EC_number="3.1.3.16" /experiment="EXISTENCE:direct assay:GO:0004721 phosphoprotein phosphatase activity [PMID:24309106]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0090029 negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:24309106]" /note="Protein phosphatase that regulates the mating response; negatively regulates the MAP kinase signaling cascade during mating; member of the serine/threonine phosphatase PP1 family" /codon_start=1 /product="protein-serine/threonine phosphatase" /protein_id="DAA11255.1" /db_xref="SGD:S000006100" /translation="MRRSPSRSNNNFAVPNCSTNSNSSQQQLTTPSDDLNSNEPNDPD DSRSLPTIKKFNNKHSINNYNTLASAGKNNNNKRASNDNLLIPGENAHKQKIYTKDEN LKSLYLDIDVSVAKALSSSATAPKLINTARTSSTTTATTSNNILTSPSYRESNYSSPS SYSFSSYYSSATSASSSTSSFLKSSGLSSRVKSPSSSVKAGSFGAPSSPTSGIPNPKS SKKPIFLRRYSHDTSSNEGLDIDVAIEKLLQVGESREITKTSKKKNFPFHSWEIQLIC YHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRG KNSLETILLLLCYKIKYKDNFFMLRGNHESANVTKMYGFYDECKRRLSSKVWKMFVDV FNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDPQV TDWSENDRGVSYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPN YCGEFHNWGAVMSVTTGMMCSFELLKPRALKNKKKLYKTKV" gene complement(210192..210263) /locus_tag="YNCP0004C" tRNA complement(210192..210263) /locus_tag="YNCP0004C" /product="tRNA-Glu" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Glutamate tRNA (tRNA-Glu), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p; target of K. lactis zymocin" /db_xref="SGD:S000006561" repeat_region 210451..210771 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007194" repeat_region 211577..211898 /note="Ty2 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007195" gene 212158..212784 /gene="CBC2" /locus_tag="YPL178W" /gene_synonym="CBP20" /gene_synonym="MUD13" /gene_synonym="SAE1" mRNA 212158..212784 /gene="CBC2" /locus_tag="YPL178W" /gene_synonym="CBP20" /gene_synonym="MUD13" /gene_synonym="SAE1" /product="nuclear cap-binding protein subunit CBC2" CDS 212158..212784 /gene="CBC2" /locus_tag="YPL178W" /gene_synonym="CBP20" /gene_synonym="MUD13" /gene_synonym="SAE1" /experiment="EXISTENCE:direct assay:GO:0000243 commitment complex [PMID:8682299]" /experiment="EXISTENCE:direct assay:GO:0000339 RNA cap binding [PMID:8682299]" /experiment="EXISTENCE:direct assay:GO:0005846 nuclear cap binding complex [PMID:8811086]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:8682299]" /note="Small subunit of the heterodimeric cap binding complex with Sto1p; interacts with Npl3p, possibly to package mRNA for export from the nucleus; may have a role in telomere maintenance; contains an RNA-binding motif" /codon_start=1 /product="nuclear cap-binding protein subunit CBC2" /protein_id="DAA11256.1" /db_xref="SGD:S000006099" /translation="MSLEEFDEVKYDHSTKRLDTPSRYLLRKARRNPNGLQELRESMK SSTIYVGNLSFYTSEEQIYELFSKCGTIKRIIMGLDRFKFTPCGFCFIIYSCPDEALN ALKYLSDTKLDEKTITIDLDPGFEDGRQFGRGKSGGQVSDELRFDFDASRGGFAIPFA ERVGVPHSRFDNSSSQSNTNNYIPPPDAMGTFRPGFDEEREDDNYVPQ" gene complement(213042..213962) /gene="CUP9" /locus_tag="YPL177C" mRNA complement(213042..213962) /gene="CUP9" /locus_tag="YPL177C" /product="Cup9p" CDS complement(213042..213962) /gene="CUP9" /locus_tag="YPL177C" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9427760]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:9427760]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17005992|PMID:10850718|PMID:9427760|PMID:18708352]" /experiment="EXISTENCE:mutant phenotype:GO:2000877 negative regulation of oligopeptide transport [PMID:17005992]" /experiment="EXISTENCE:mutant phenotype:GO:2000879 negative regulation of dipeptide transport [PMID:10850718|PMID:9427760|PMID:17005992|PMID:18708352]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:18708352]" /note="Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="Cup9p" /protein_id="DAA11257.1" /db_xref="SGD:S000006098" /translation="MNYNCEIQNRNSKNVDNQVSLPPIQVLFNSIEKRSMPELAFSNI EYSHGNLRSSTEEQNYPAPVLLPQHHSIAYPAINSGGTSTTATPTASTVETSKTSSSA MDTQSQYGSSKKSKSASDDAKPCYKSAPIYEIINKEKDAGAQYNRPFSDFVESKSRRK QNSGRRSNLPKETVQILNTWLLNHLNNPYPTQQEKRELLIKTGLTKIQLSNWFINVRR RKIFSDYYTLVNSIPNDNANNTPVERVQNVSAYHNTLSATNNTMYDATSTCSTDYELS KRFAHAPVTRRKKLIDRLEELKKLSNPDMN" gene complement(216012..218363) /gene="TRE1" /locus_tag="YPL176C" mRNA complement(216012..218363) /gene="TRE1" /locus_tag="YPL176C" /product="Tre1p" CDS complement(216012..218363) /gene="TRE1" /locus_tag="YPL176C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:16456538|PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:19369420]" /note="Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitination and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication" /codon_start=1 /product="Tre1p" /protein_id="DAA11258.1" /db_xref="SGD:S000006097" /translation="MVNTRGYTTLPNVEEPANNSQDELNSQDFEQAIGMPSEPPVYVE EMGMEEPQAPEAFSEKVQRFRMCFENNVVIPVKKNVVDPLAQMISLASEKFDLFLSKI GNVMVMRRIFYIMMMSIIAALIIASDRLPNGKARGSNGSFSDHDLLLQYARKSIDLSK IERDLEYISSMPHMSGTSGDAAIRHYIKESFDKNGIRLAGEEEFMAYSNYPGNVSLRV YSKDDTEGFDIPLNEENFNPMSHNGQLNNIPVIYANKASLDDMASMQDQGLLNGDFIL LVHYGDYVFQQMLTAQEYGAKAIIFISEPYQDNKDVIQMKSVALPQYGTGDALTPEWE GSIRDPIDATEAKCLPKIPSIPISANQGDKILAILSDTGVKFSNNLFSGSLNDCRLDL LVQTAIRERHPVHDIVGKIEGSEQAGRAIVIAAPRNSASYGTMYPSFGTVVLLSLIQL YQEMVYKFDWKPLRNIYFISFGGSEFNEAGATELMEKRTEALKSEIYTIIDVGQIGIW DDSNNLEIQCHPLLVDLFQKNMTSRKFNVKVDNVHQFGDWTPYLAQGIPVAIISSPGV MNREHPIYTVEDKFDFIKDKLRDKKKGEVLSEIMLYLVEKSLELIDDPFIPFSISNYV DFLSTTLKDLQKECPDTVNFDEVFLGTTLWENTKLQFEKWKSEWTELMYGAGTYIEPT IIAINRWSWNYLLSLIGVTQCLEEGLMDRTFYKNVIFGPKLWVDKGDPLRSWTFPEIR DTIAIKDWSSVQVQANTLGTILQNTARYFLENKNLHGINTNEF" gene 218630..220088 /gene="SPT14" /locus_tag="YPL175W" /gene_synonym="CWH6" /gene_synonym="GPI3" mRNA join(218630..218646,218747..220088) /gene="SPT14" /locus_tag="YPL175W" /gene_synonym="CWH6" /gene_synonym="GPI3" /product="phosphatidylinositol N-acetylglucosaminyltransferase SPT14" CDS join(218630..218646,218747..220088) /gene="SPT14" /locus_tag="YPL175W" /gene_synonym="CWH6" /gene_synonym="GPI3" /EC_number="2.4.1.198" /experiment="EXISTENCE:curator inference:GO:0006506 GPI anchor biosynthetic process [PMID:10970797]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005783 endoplasmic reticulum [PMID:9079905]" /experiment="EXISTENCE:mutant phenotype:GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity [PMID:10970797]" /note="UDP-glycosyltransferase subunit of the GPI-GnT complex; UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins" /codon_start=1 /product="phosphatidylinositol N-acetylglucosaminyltransferase SPT14" /protein_id="DAA11259.1" /db_xref="SGD:S000006096" /translation="MGFNIAMLCDFFYPQLGGVEFHIYHLSQKLIDLGHSVVIITHAY KDRVGVRHLTNGLKVYHVPFFVIFRETTFPTVFSTFPIIRNILLREQIQIVHSHGSAS TFAHEGILHANTMGLRTVFTDHSLYGFNNLTSIWVNKLLTFTLTNIDRVICVSNTCKE NMIVRTELSPDIISVIPNAVVSEDFKPRDPTGGTKRKQSRDKIVIVVIGRLFPNKGSD LLTRIIPKVCSSHEDVEFIVAGDGPKFIDFQQMIESHRLQKRVQLLGSVPHEKVRDVL CQGDIYLHASLTEAFGTILVEAASCNLLIVTTQVGGIPEVLPNEMTVYAEQTSVSDLV QATNKAINIIRSKALDTSSFHDSVSKMYDWMDVAKRTVEIYTNISSTSSADDKDWMKM VANLYKRDGIWAKHLYLLCGIVEYMLFFLLEWLYPRDEIDLAPKWPKKTVSNETKEAR ET" rep_origin 220088..220167 /note="ARS1611; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay" /db_xref="SGD:S000130197" gene complement(220167..222773) /gene="NIP100" /locus_tag="YPL174C" /gene_synonym="PAC13" mRNA complement(220167..222773) /gene="NIP100" /locus_tag="YPL174C" /gene_synonym="PAC13" /product="Nip100p" CDS complement(220167..222773) /gene="NIP100" /locus_tag="YPL174C" /gene_synonym="PAC13" /experiment="EXISTENCE:direct assay:GO:0005869 dynactin complex [PMID:9658168]" /experiment="EXISTENCE:mutant phenotype:GO:0000132 establishment of mitotic spindle orientation [PMID:9658168]" /note="Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)" /codon_start=1 /product="Nip100p" /protein_id="DAA11260.1" /db_xref="SGD:S000006095" /translation="MRNAGVQVDTNMQKISLQDTVLVNEMKGRVKFIGETQFAKGIWY GIELDKPLGKNDGSANGIRYFDIDLKKANSNGGYYGLFCKKDTLQFYKPDDDEHSLLN GNAAQETIKNLQVKCESLASKLNKIKIENHELKTSVEKLSTNETVLLSKISRLDKLVK ELKVENGNMKTHLDNFNHLLDASDSVMAPDLDKGTLLERSHLLQGLLDQTKLSYDKAM KVQEDLLEENTQLLEENAVLSKKISDLGLQLQQTNNTIGDLALQIEAQSKSSNIVDKL TNDNILLTSNIKALNNELEELQAKEKLDENLRITYEQLEQELRLQLSNLQSALENEKE IAGTYIEENSRLKATLESIEAKTSHKFQSLELKVNTLQEELYQNKLLKKFYQIYEPFA QPHLAALSSQLQYLAEVIESENFGKLENIEIHIILKVLSSISYALHIYTIKNTPDHLE TTLQCFKVNIAPISMWLSEFLQRKFSSKQETAFSICQFLEDNKFLDKDVTLILKILHP ILETTVPKLLAFLRTNSNFNDNDTLCLIGSLYERSLSLIARIDKLIGKEEISKQDNRL FLYPSCDITLSSILTILFSDALFLRQDYKRISSLKKLEVFFQGIESLLENITIFPEQP SQQTSDSESQCNIKEGNFSNSLLSDRLNEENIRLKEVLVQKENMLTELETKIKIIIGR DLERKTLEENIKTLKVELNNKNEENCGKTEILNKLKEENFNLVNRLKNMELKLYQIKD NNTLNKIYLDREKVDRVNLVSEIMELRETIRRQIKEQKRVSIDFSWLDELPAVENKQP FKEHINHSLDTLGIEMFNFVSTSRILDLKLDQPLAEDELWHERDHSYISYLKRKRKNI RLKSQNVVTYYK" gene 223143..224036 /gene="MRPL40" /locus_tag="YPL173W" /gene_synonym="uL24m" mRNA 223143..224036 /gene="MRPL40" /locus_tag="YPL173W" /gene_synonym="uL24m" /product="mitochondrial 54S ribosomal protein YmL40" CDS 223143..224036 /gene="MRPL40" /locus_tag="YPL173W" /gene_synonym="uL24m" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552|PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978|PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit" /codon_start=1 /product="mitochondrial 54S ribosomal protein uL24m MRPL40" /protein_id="DAA11261.1" /db_xref="SGD:S000006094" /translation="MSGSYQHLSNVGSRVMKRLGNRPKNFLPHSEKFIKKSTPEFMKS DLKEVDEKTSFKSEKEWKFIPGDRVVVMSGASKGNIAVIKSFDKRTNSFILDENGPTK TVPVPKQFWLEGQTSHMITIPVSILGKDLRLVADIDDEKTPGKTRTVAVRDVSFNGSY YDADYKKVMPYRCVKGQPDLIIPWPKPDPIDVQTNLATDPVIAREQTFWVDSVVRNPI PKKAIPSIRNPHSKYKRGTLTAKDIAKLVAPEMPLTEVRKSHLAEKKELAEREVPKLT EEDMEAIGARVFEFLEKQKRE" gene complement(224353..225741) /gene="COX10" /locus_tag="YPL172C" mRNA complement(224353..225741) /gene="COX10" /locus_tag="YPL172C" /product="protoheme IX farnesyltransferase" CDS complement(224353..225741) /gene="COX10" /locus_tag="YPL172C" /EC_number="2.5.1.141" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0006784 heme A biosynthetic process [PMID:8118433]" /note="Heme A:farnesyltransferase; catalyzes first step in conversion of protoheme to heme A prosthetic group required for cytochrome c oxidase activity; human ortholog COX10 can complement yeast cox10 null mutant; human ortholog COX10 is associated with mitochondrial disorders" /codon_start=1 /product="protoheme IX farnesyltransferase" /protein_id="DAA11262.1" /db_xref="SGD:S000006093" /translation="MSYFPRTYAHLMRNVLAHNKGNIYLQIGTQLHDTQIKIRFNGVR YISRNHGGKQQHINTAPIEFTPNFGYGDRTSNCNKKVESTAMKTLRCTDDISTSSGSE ATTDASTQLPFNVKLVDPMVRKSKRPSHAISEGLNMKTLKKKVIMPYLQLTKPRLTIL VMLSAICSYALSPYPASVNELLCLTVGTTLCSGSANAINMGREPEFDRQMVRTQARPV VRGDVTPTQAFEFAALIGTLGVSILYFGVNPTVAILGASNIALYGWAYTSMKRKHIIN TWLGALVGMVPPLMGWAAASPLSHPGSWCLAGLLFAWQFPHFNTLSHNIRNEYKNAGY VMTAWKNPLLNARVSLRYSILMFPLCFGLSYFNITDWYYQIDSGLINAWLTFWAFKFY WQQRINYSAKTLKDNVKFNKGLSVANIYARKTFMASVLHLPAILILAIIHKKGRWDWI YPGEAKRPQERF" gene complement(226169..227371) /gene="OYE3" /locus_tag="YPL171C" /gene_synonym="ZRG6" mRNA complement(226169..227371) /gene="OYE3" /locus_tag="YPL171C" /gene_synonym="ZRG6" /product="NADPH dehydrogenase" CDS complement(226169..227371) /gene="OYE3" /locus_tag="YPL171C" /gene_synonym="ZRG6" /EC_number="1.6.99.1" /experiment="EXISTENCE:direct assay:GO:0003959 NADPH dehydrogenase activity [PMID:7836424]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:17897954]" /note="Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death" /codon_start=1 /product="NADPH dehydrogenase" /protein_id="DAA11263.1" /db_xref="SGD:S000006092" /translation="MPFVKGFEPISLRDTNLFEPIKIGNTQLAHRAVMPPLTRMRATH PGNIPNKEWAAVYYGQRAQRPGTMIITEGTFISPQAGGYDNAPGIWSDEQVAEWKNIF LAIHDCQSFAWVQLWSLGWASFPDVLARDGLRYDCASDRVYMNATLQEKAKDANNLEH SLTKDDIKQYIKDYIHAAKNSIAAGADGVEIHSANGYLLNQFLDPHSNKRTDEYGGTI ENRARFTLEVVDALIETIGPERVGLRLSPYGTFNSMSGGAEPGIIAQYSYVLGELEKR AKAGKRLAFVHLVEPRVTDPSLVEGEGEYSEGTNDFAYSIWKGPIIRAGNYALHPEVV REQVKDPRTLIGYGRFFISNPDLVYRLEEGLPLNKYDRSTFYTMSAEGYTDYPTYEEA VDLGWNKN" gene 228314..228772 /gene="DAP1" /locus_tag="YPL170W" mRNA 228314..228772 /gene="DAP1" /locus_tag="YPL170W" /product="Dap1p" CDS 228314..228772 /gene="DAP1" /locus_tag="YPL170W" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:17954932]" /experiment="EXISTENCE:direct assay:GO:0020037 heme binding [PMID:15713626]" /experiment="EXISTENCE:genetic interaction:GO:0032443 regulation of ergosterol biosynthetic process [PMID:15713626]" /experiment="EXISTENCE:mutant phenotype:GO:0032443 regulation of ergosterol biosynthetic process [PMID:17954932]" /note="Heme-binding protein; involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis" /codon_start=1 /product="Dap1p" /protein_id="DAA11264.1" /db_xref="SGD:S000006091" /translation="MSFIKNLLFGGVKTSEDPTGLTGNGASNTNDSNKGSEPVVAGNF FPRTLSKFNGHDDEKIFIAIRGKVYDCTRGRQFYGPSGPYTNFAGHDASRGLALNSFD LDVIKDWDQPIDPLDDLTKEQIDALDEWQEHFENKYPCIGTLIPEPGVNV" gene complement(229039..230838) /gene="MEX67" /locus_tag="YPL169C" mRNA complement(229039..230838) /gene="MEX67" /locus_tag="YPL169C" /product="Mex67p" CDS complement(229039..230838) /gene="MEX67" /locus_tag="YPL169C" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:29212662]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:12524544]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:31753862]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0015288 porin activity [PMID:31753862]" /experiment="EXISTENCE:direct assay:GO:0017070 U6 snRNA binding [PMID:31189105]" /experiment="EXISTENCE:direct assay:GO:0030619 U1 snRNA binding [PMID:31189105]" /experiment="EXISTENCE:direct assay:GO:0030620 U2 snRNA binding [PMID:31189105]" /experiment="EXISTENCE:direct assay:GO:0030621 U4 snRNA binding [PMID:31189105]" /experiment="EXISTENCE:direct assay:GO:0030623 U5 snRNA binding [PMID:31189105]" /experiment="EXISTENCE:genetic interaction:GO:0000055 ribosomal large subunit export from nucleus [PMID:17434126]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:17434126|PMID:31439809]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:22956913]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:10722667]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:29212662]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:29212662]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:27385342]" /experiment="EXISTENCE:mutant phenotype:GO:0071528 tRNA re-export from nucleus [PMID:33074312]" /experiment="EXISTENCE:physical interaction:GO:0042272 nuclear RNA export factor complex [PMID:9774696]" /note="Poly(A) RNA binding protein involved in nuclear mRNA export; component of the nuclear pore and nuclear RNA export factor; ubiquitin-associated (UBA) domain interacts with Mip6p; ortholog of human TAP" /codon_start=1 /product="Mex67p" /protein_id="DAA11265.1" /db_xref="SGD:S000006090" /translation="MSGFHNVGNINMMAQQQMQQNRIKISVRNWQNATMNDLINFISR NARVAVYDAHVEGPLVIGYVNSKAEAESLMKWNGVRFAGSNLKFELLDNNGASAGTSD TISFLRGVLLKRYDPQTKLLNLGALHSDPELIQKGVFSSISTQSKMFPAMMKLASTEK SLIVESVNLADNQLKDISAISTLAQTFPNLKNLCLANNQIFRFRSLEVWKNKFKDLRE LLMTNNPITTDKLYRTEMLRLFPKLVVLDNVIVRDEQKLQTVYSLPMKIQQFFFENDA LGQSSTDFATNFLNLWDNNREQLLNLYSPQSQFSVSVDSTIPPSTVTDSDQTPAFGYY MSSSRNISKVSSEKSIQQRLSIGQESINSIFKTLPKTKHHLQEQPNEYSMETISYPQI NGFVITLHGFFEETGKPELESNKKTGKNNYQKNRRYNHGYNSTSNNKLSKKSFDRTWV IVPMNNSVIIASDLLTVRAYSTGAWKTASIAIAQPPQQQASVLPQVASMNPNITTPPQ PQPSVVPGGMSIPGAPQGAMVMAPTLQLPPDVQSRLNPVQLELLNKLHLETKLNAEYT FMLAEQSNWNYEVAIKGFQSSMNGIPREAFVQF" gene 231217..232509 /gene="MRX4" /locus_tag="YPL168W" mRNA 231217..232509 /gene="MRX4" /locus_tag="YPL168W" /product="Mrx4p" CDS 231217..232509 /gene="MRX4" /locus_tag="YPL168W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated" /codon_start=1 /product="Mrx4p" /protein_id="DAA11266.1" /db_xref="SGD:S000006089" /translation="MTVLYTSASLKKMKCLAFNMGMNCVRTVSHARSGGAKFGGRNVF NIFDSKTPDSVRIKAFKNTIYQSAMGKGKTKFSAMEINLITSLVRGYKGEGKKNAINP LQTNVQILNKLLLTHRLTDKDILEGMNLAAGPVNVAIPRDITPQEEKKKVELRNRKAE NMDLHPSRKMHIKELLHSLNLDMCNDEEVYQKISLYLQKNEESRTSVGASQQNHVDID INSLKRYLQNIEKKARQKSAIDKQKKNQARIYQWNTQSFSEIVPLSAGNILFKREPNR LWKRLQNGISVFLGSNGGGKKSKTTKKVLQGNNILLHSLENNKDMTLSNNFDHSVFNI NFTDLFGVINASGSPPDRVLNEINEIELKGWKCVGNLYDNNKIVVFQSSNPLLEDTKI PQKSFTNSKRFLISLSALLASFFAYYRYRLSQRQESKK" gene complement(232593..237107) /gene="REV3" /locus_tag="YPL167C" /gene_synonym="PSO1" mRNA complement(232593..237107) /gene="REV3" /locus_tag="YPL167C" /gene_synonym="PSO1" /product="DNA-directed DNA polymerase" CDS complement(232593..237107) /gene="REV3" /locus_tag="YPL167C" /gene_synonym="PSO1" /EC_number="2.7.7.7" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:8658138]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16452144]" /experiment="EXISTENCE:direct assay:GO:0016035 zeta DNA polymerase complex [PMID:22711820|PMID:23066099|PMID:8658138]" /experiment="EXISTENCE:direct assay:GO:0042276 error-prone translesion synthesis [PMID:17248528|PMID:11313481]" /experiment="EXISTENCE:direct assay:GO:0070987 error-free translesion synthesis [PMID:12514101]" /experiment="EXISTENCE:genetic interaction:GO:0042276 error-prone translesion synthesis [PMID:9765213]" /note="Catalytic subunit of DNA polymerase zeta (pol zeta); involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; may be involved in meiosis; forms a complex with Rev7p, Pol31p and Pol32p" /codon_start=1 /product="DNA-directed DNA polymerase" /protein_id="DAA11267.1" /db_xref="SGD:S000006088" /translation="MSRESNDTIQSDTVRSSSKSDYFRIQLNNQDYYMSKPTFLDPSH GESLPLNQFSQVPNIRVFGALPTGHQVLCHVHGILPYMFIKYDGQITDTSTLRHQRCA QVHKTLEVKIRASFKRKKDDKHDLAGDKLGNLNFVADVSVVKGIPFYGYHVGWNLFYK ISLLNPSCLSRISELIRDGKIFGKKFEIYESHIPYLLQWTADFNLFGCSWINVDRCYF RSPVLNSILDIDKLTINDDLQLLLDRFCDFKCNVLSRRDFPRVGNGLIEIDILPQFIK NREKLQHRDIHHDFLEKLGDISDIPVKPYVSSARDMINELTMQREELSLKEYKEPPET KRHVSGHQWQSSGEFEAFYKKAQHKTSTFDGQIPNFENFIDKNQKFSAINTPYEALPQ LWPRLPQIEINNNSMQDKKNDDQVNASFTEYEICGVDNENEGVKGSNIKSRSYSWLPE SIASPKDSTILLDHQTKYHNTINFSMDCAMTQNMASKRKLRSSVSANKTSLLSRKRKK VMAAGLRYGKRAFVYGEPPFGYQDILNKLEDEGFPKIDYKDPFFSNPVDLENKPYAYA GKRFEISSTHVSTRIPVQFGGETVSVYNKPTFDMFSSWKYALKPPTYDAVQKWYNKVP SMGNKKTESQISMHTPHSKFLYKFASDVSGKQKRKKSSVHDSLTHLTLEIHANTRSDK IPDPAIDEVSMIIWCLEEETFPLDLDIAYEGIMIVHKASEDSTFPTKIQHCINEIPVM FYESEFEMFEALTDLVLLLDPDILSGFEIHNFSWGYIIERCQKIHQFDIVRELARVKC QIKTKLSDTWGYAHSSGIMITGRHMINIWRALRSDVNLTQYTIESAAFNILHKRLPHF SFESLTNMWNAKKSTTELKTVLNYWLSRAQINIQLLRKQDYIARNIEQARLIGIDFHS VYYRGSQFKVESFLIRICKSESFILLSPGKKDVRKQKALECVPLVMEPESAFYKSPLI VLDFQSLYPSIMIGYNYCYSTMIGRVREINLTENNLGVSKFSLPRNILALLKNDVTIA PNGVVYAKTSVRKSTLSKMLTDILDVRVMIKKTMNEIGDDNTTLKRLLNNKQLALKLL ANVTYGYTSASFSGRMPCSDLADSIVQTGRETLEKAIDIIEKDETWNAKVVYGDTDSL FVYLPGKTAIEAFSIGHAMAERVTQNNPKPIFLKFEKVYHPSILISKKRYVGFSYESP SQTLPIFDAKGIETVRRDGIPAQQKIIEKCIRLLFQTKDLSKIKKYLQNEFFKIQIGK VSAQDFCFAKEVKLGAYKSEKTAPAGAVVVKRRINEDHRAEPQYKERIPYLVVKGKQG QLLRERCVSPEEFLEGENLELDSEYYINKILIPPLDRLFNLIGINVGNWAQEIVKSKR ASTTTTKVENITRVGTSATCCNCGEELTKICSLQLCDDCLEKRSTTTLSFLIKKLKRQ KEYQTLKTVCRTCSYRYTSDAGIENDHIASKCNSYDCPVFYSRVKAERYLRDNQSVQR EEALISLNDW" gene 237338..237979 /gene="ATG29" /locus_tag="YPL166W" mRNA 237338..237979 /gene="ATG29" /locus_tag="YPL166W" /product="Atg29p" CDS 237338..237979 /gene="ATG29" /locus_tag="YPL166W" /experiment="EXISTENCE:direct assay:GO:0000045 autophagosome assembly [PMID:18725539]" /experiment="EXISTENCE:direct assay:GO:0000149 SNARE binding [PMID:26774783]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:16289106]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006995 cellular response to nitrogen starvation [PMID:18725539|PMID:26774783]" /experiment="EXISTENCE:direct assay:GO:0034497 protein localization to phagophore assembly site [PMID:26774783]" /experiment="EXISTENCE:direct assay:GO:1990316 Atg1/ULK1 kinase complex [PMID:26753620]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:16289106]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /note="Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" /codon_start=1 /product="Atg29p" /protein_id="DAA11268.1" /db_xref="SGD:S000006087" /translation="MIMNSTNTVVYIKVKGRRPQGFLDPPKFEWNGTKERQLWTMVSN LNYSQDQIDWQNLSKIFETPEFFLKKRTYKLFAEHLELLQLQLEKKRDLEKYSNDQVN EGMSDLIHKYTPTLQNDNLLNVSASPLTTERQDSEEVETEVTNEALQHLQTSKILNIH KKTSDSENKPNDKLDKDGINKEMECGSSDDDLSSSLSVSKSALEEALMDRLQF" gene complement(237956..239077) /gene="SET6" /locus_tag="YPL165C" mRNA complement(237956..239077) /gene="SET6" /locus_tag="YPL165C" /product="Set6p" CDS complement(237956..239077) /gene="SET6" /locus_tag="YPL165C" /note="SET domain hypothetical protein; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability" /codon_start=1 /product="Set6p" /protein_id="DAA11269.1" /db_xref="SGD:S000006086" /translation="MTIDGDVHEISPFFQVRQTKWGGRACFSNGNIPKGTTVLQVSNF TGTSISYEFRKEVCHNCFAYANAKTMKYKLNYDYLRDLVCNAHYQINPKKFLGAGLWF CSEHCRTSYLQIPNIIELIECYEILLHHFPSMLKRYNYTSEQEEKLNSILISENVIQS SWDEIESKWIPRINNMKSAKRINQLPPTCEDEYCCIRFVCESLFNLKYMDPQCITYRA FNMLQSNELSKISKFPVLLHFQKLVFQTLYILLPSHLHRMLSIPLLRHILGTEYGNAF GLWQEGEASDSREYFGYWVFPEASYFNHSCNPNITKYRKGNSMLFTMNRDIKKDEQIC IDYSGVLDLPTVKRRAFLADSWFFDCACERCKSELQSVH" gene complement(239350..241497) /gene="MLH3" /locus_tag="YPL164C" mRNA complement(239350..241497) /gene="MLH3" /locus_tag="YPL164C" /product="mismatch repair protein MLH3" CDS complement(239350..241497) /gene="MLH3" /locus_tag="YPL164C" /experiment="EXISTENCE:mutant phenotype:GO:0000710 meiotic mismatch repair [PMID:23316435]" /experiment="EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:9770499|PMID:10679328]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10570173]" /experiment="EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:10570173]" /experiment="EXISTENCE:physical interaction:GO:0097587 MutLgamma complex [PMID:10570173|PMID:9770499]" /note="Protein involved in DNA mismatch repair and meiotic recombination; involved in crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability" /codon_start=1 /product="mismatch repair protein MLH3" /protein_id="DAA11270.1" /db_xref="SGD:S000006085" /translation="MSQHIRKLDSDVSERLKSQACTVSLASAVREIVQNSVDAHATTI DVMIDLPNLSFAVYDDGIGLTRSDLNILATQNYTSKIRKMNDLVTMKTYGYRGDALYS ISNVSNLFVCSKKKDYNSAWMRKFPSKSVMLSENTILPIDPFWKICPWSRTKSGTVVI VEDMLYNLPVRRRILKEEPPFKTFNTIKADMLQILVMHPMISLNVQYTDKLRINTEVL FRSKNITEGLTKHQQMSQVLRNVFGAIIPPDMLKKVSLKFNEYQIEGIISKMPVGLKD LQFIYINGRRYADSAFQGYVDSLFQAQDFGEKGMSLLKTKSVGKPYRSHPVFILDVRC PQTIDDLLQDPAKKIVKPSHIRTIEPLIVKTIRSFLTFQGYLTPDKSDSSFEIVNCSQ KTATLPDSRIQISKRNQVLNSKMKIARINSYIGKPAVNGCRINNSTINYEKIKNIRID GQKSRLRNKLSSRPYDSGFTEDYDSIGKTITDFSISRSVLAKYEVINQVDKKFILIRC LDQSIHNCPLLVLVDQHACDERIRLEELFYSLLTEVVTGTFVARDLKDCCIEVDRTEA DLFKHYQSEFKKWGIGYETIEGTMETSLLEIKTLPEMLTSKYNGDKDYLKMVLLQHAH DLKDFKKLPMDLSHFENYTSVDKLYWWKYSSCVPTVFHEILNSKACRSAVMFGDELTR QECIILISKLSRCHNPFECAHGRPSMVPIAELK" gene complement(241918..242700) /gene="SVS1" /locus_tag="YPL163C" mRNA complement(241918..242700) /gene="SVS1" /locus_tag="YPL163C" /product="Svs1p" CDS complement(241918..242700) /gene="SVS1" /locus_tag="YPL163C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11935221]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication" /codon_start=1 /product="Svs1p" /protein_id="DAA11271.1" /db_xref="SGD:S000006084" /translation="MIFKILCSLLLVTSNFASALYVNETTSYTPYTKTLTPTYSVSPQ ETTLTYSDETTTFYITSTFYSTYWFTTSQSAAIISTPTASTPTASTPSLTTSTNEYTT TYSDTDTTYTSTLTSTYIITLSTESANEKAEQISTSVTEIASTVTESGSTYTSTLTST LLVTVYNSQASNTIATSTAGDAASNVDALEKLVSAEHQSQMIQTTSADEQYCSASTKY VTVTAAAVTEVVTTTAEPVVKYVTITADASNVTGSANNGTHI" gene complement(243206..244027) /locus_tag="YPL162C" mRNA complement(243206..244027) /locus_tag="YPL162C" /product="hypothetical protein" CDS complement(243206..244027) /locus_tag="YPL162C" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11272.1" /db_xref="SGD:S000006083" /translation="MYVSNGKDTCQLLGPVSLFVQTLMGMTAVIVLLVKRNYEHPRRK MIVWSYDIGKQIIGSLGIHFLNLGISILKKRRRSLFAITAKGNDDEDQCDWYFLNLLL DTTVGIPILWLCLYIIEKVLKSLHFQNIESGNYFPSKTVGSHPRKPLFSAFVKQLLIF IVGLGVMKFCVFLILNYLEDLAYWFADLILGWSDSWPNFQVFLVMFVFPILLNCFQYF CVDNVIRLHSESLTITNAENFETNTFLNDEIPDLSEVSNEVPNKDNNISSYGSII" gene complement(244319..246220) /gene="BEM4" /locus_tag="YPL161C" /gene_synonym="ROM7" mRNA complement(244319..246220) /gene="BEM4" /locus_tag="YPL161C" /gene_synonym="ROM7" /product="Bem4p" CDS complement(244319..246220) /gene="BEM4" /locus_tag="YPL161C" /gene_synonym="ROM7" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0007266 Rho protein signal transduction [PMID:8754839]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:8754839]" /note="Protein involved in establishment of cell polarity and bud emergence; regulates filamentous-growth mitogen-activated protein kinase (MAPK) pathway; interacts with the Rho1p small GTP-binding protein, the pleckstrin homology (PH) domain of Cdc24p, and with the Rho-type GTPase Cdc42p; stabilizes Cdc42p levels, resulting in elevated fMAPK pathway signaling; involved in maintenance of proper telomere length" /codon_start=1 /product="Bem4p" /protein_id="DAA11273.1" /db_xref="SGD:S000006082" /translation="MDYEEILFGLQPILNASSIKDVPMNDVYLGSYLAVMDQLAVSLR EPSNRDIVGKTGLLLNLVRVLEQALDICFHDTSISINDKIAFYEISSEVIRCIANAII DNDDNREILLDSGGKKLLNYYIGGVLQLDEISSDKSEDSLVDKLQMRSVVLLRNFCIG NLKYTENLAPFIRGPLFVLLKTTQYSYLSSPEKVVLGSDLLNDILKVNYSNVQISDLF FLSQYIKKISSNVQNKELQAMEDGAVEAYSNTETQKFAGQGNQEYIEKEEEDDEEDVN CELLLNLSTCLETIVAKDETINFTNEEQLVLSMQKNLILSLVCLESKTFNNKLIVMRR LISCAGNISANLTNSNKREQSLCIETIKSSASSYALAAALMILCNSVASKSDAVALLK LISLSELIQVGSLLQDPLQYQGFLDLLRKLLNLENTMWLDIKDLFTLFQIMRRCHEQT KYYNNLRSLLTNLLNKTLTVLPSSKIHNSISSDPTIISFIAEHGTLTSCIAMDKLLVS KKALPKEAITSLWDSIFKFQNLGQAEQLSISDLFHITKTVGIYLKDSSVTADVNPIEN ILFKDYIQKLTLILETILSFKENKDKGSESCFNNGKFIAGIILNIVKNTKCLTPEEQN LEALAKSFF" gene 246990..250262 /gene="CDC60" /locus_tag="YPL160W" mRNA 246990..250262 /gene="CDC60" /locus_tag="YPL160W" /product="leucine--tRNA ligase CDC60" CDS 246990..250262 /gene="CDC60" /locus_tag="YPL160W" /EC_number="6.1.1.4" /experiment="EXISTENCE:direct assay:GO:0004823 leucine-tRNA ligase activity [PMID:9742237]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9742237]" /experiment="EXISTENCE:direct assay:GO:0006429 leucyl-tRNA aminoacylation [PMID:9742237]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /experiment="EXISTENCE:mutant phenotype:GO:1903432 regulation of TORC1 signaling [PMID:22424774]" /experiment="EXISTENCE:physical interaction:GO:1903432 regulation of TORC1 signaling [PMID:22424774]" /note="Cytosolic leucyl tRNA synthetase; ligates leucine to the appropriate tRNA; human homolog LARS can complement yeast temperature-sensitive mutant at restrictive temperature" /codon_start=1 /product="leucine--tRNA ligase CDC60" /protein_id="DAA11274.1" /db_xref="SGD:S000006081" /translation="MSSGLVLENTARRDALIAIEKKYQKIWAEEHQFEIDAPSIEDEP ITMDSEELHRTYPKFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKRALFPLG FHCTGMPILACADKLKREAELFGKNFDNVPAEEEEIKEETPAEKDHEDVTKFKAKKSK AAAKKGRGKYQFEIMLQLGIPREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRS FVTTDANPYYDAFIRWQMNKLKAAGKIKFGERYTIYSEKDGQACMDHDRQSGEGVTPQ EYIGVKIEALEFADDAAKIIDSSSDLDKSKKFYFVAATLRPETMYGQTCCFVSPTIEY GIFDAGDSYFITTERAFKNMSYQKLTPKRGFYKPIVTVPGKAFIGTKIHAPQSVYPEL RILPMETVIATKGTGVVTCVPSNSPDDYITTKDLLHKPEYYGIKPEWIDHEIVPIMHT EKYGDLTAKAIVEEKKIQSPKDKNLLAEAKKIAYKEDYYTGTMIYGPYKGEKVEQAKN KVKADMIAAGEAFVYNEPESQVMSRSGDDCIVSLEDQWYVDYGEESWKKQAIECLEGM QLFAPEVKNAFEGVLDWLKNWAVCRTYGLGTRLPWDEKYLVESLSDSTIYQSFYTIAH LLFKDYYGNEIGPLGISADQMTDEVFDYIFQHQDDVKNTNIPLPALQKLRREFEYFYP LDVSISGKDLIPNHLTFFIYTHVALFPKKFWPKGIRANGHLMLNNSKMSKSTGNFMTL EQTVEKFGADAARIAFADAGDTVEDANFDESNANAAILRLFNLKEWAEEITKESNLRT GEITDFFDIAFEHEMNALIEKTYEQYALTNYKNALKYGLFDFQAARDYYREASGVMHK DLIARYIETQALLLAPIAPHFAEYIYREVLGNQTSVQNAKFPRASKPVDKGVLAALDY LRNLQRSIREGEGQALKKKKGKSAEIDASKPVKLTLLISESFPEWQSQCVEIVRKLFS EQTLDDNKKVREHIEPKEMKRAMPFISLLKQRLANEKPEDVFERELQFSEIDTVKAAA RNVKKAAQALKIAEFSAISFPYGAKTGKDIFTGEEVEIPPVTKIVENAVPGNPGVVFQ NI" gene complement(250907..251668) /gene="PET20" /locus_tag="YPL159C" mRNA complement(250907..251668) /gene="PET20" /locus_tag="YPL159C" /product="Pet20p" CDS complement(250907..251668) /gene="PET20" /locus_tag="YPL159C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16491469]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:16491469]" /note="Mitochondrial protein; required for respiratory growth under some conditions and for stability of the mitochondrial genome; subunit of a complex containing Mrx6p, Pim1p, and Mam33p that may regulate mtDNA replication" /codon_start=1 /product="Pet20p" /protein_id="DAA11275.1" /db_xref="SGD:S000006080" /translation="MLKLARPFIPPLSRNNAISSGIVLTSRRFQSSFTFLSNQSLLSK NQMKSKRKKGSKKAAYHRQPPEHEHTAPLIKQNKTITKKEHSDVRGSHLKKKRSDFSW LPRVPSTSHLKQSDMTTNVLYSGYRPLFINPNDPKLKEDTGSTLYEFAMKLEDLNEPL SPWISSATGLEFFSEWENIPSELLKNLKPFHPPKEKSMNTNELIHVSAKRNTLVDNKT SETLQRKMDEFSKRRGKGRKKSVVTLLQMKKKLEG" gene complement(252034..254310) /gene="AIM44" /locus_tag="YPL158C" /gene_synonym="GPS1" mRNA complement(252034..254310) /gene="AIM44" /locus_tag="YPL158C" /gene_synonym="GPS1" /product="Aim44p" CDS complement(252034..254310) /gene="AIM44" /locus_tag="YPL158C" /gene_synonym="GPS1" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:28148650]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:28148650|PMID:22842922|PMID:24451263|PMID:23468594|P MID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032153 cell division site [PMID:25416945]" /experiment="EXISTENCE:direct assay:GO:0032174 cellular bud neck septin collar [PMID:30341817]" /experiment="EXISTENCE:direct assay:GO:0032177 cellular bud neck split septin rings [PMID:30341817]" /experiment="EXISTENCE:genetic interaction:GO:1990344 secondary cell septum biogenesis [PMID:23468594]" /experiment="EXISTENCE:mutant phenotype:GO:0005637 nuclear inner membrane [PMID:30341817]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:30341817]" /experiment="EXISTENCE:mutant phenotype:GO:0005935 cellular bud neck [PMID:23468594]" /experiment="EXISTENCE:mutant phenotype:GO:0045185 maintenance of protein location [PMID:23468594]" /experiment="EXISTENCE:mutant phenotype:GO:0098841 protein localization to cell division site after cytokinesis [PMID:25416945]" /experiment="EXISTENCE:mutant phenotype:GO:1901900 regulation of protein localization to cell division site [PMID:23468594]" /experiment="EXISTENCE:mutant phenotype:GO:1903473 positive regulation of mitotic actomyosin contractile ring contraction [PMID:24451263]" /experiment="EXISTENCE:mutant phenotype:GO:1990344 secondary cell septum biogenesis [PMID:23468594]" /note="Regulator of Cdc42p and Rho1p; regulates AMR closure through Hof1p; inhibits Cdc42-dependent Cla4 activation at the division site, to prevent budding in the old bud neck; recruits Nis1p and Nba1p to the division site with Nap1 and the Rax1p-Rax2p dependent inheritance of Nis1p and Nba1p to bud scars to prevent division site repolarization; keeps Rho1p at the division site after AMR contraction to control secondary septum formation; relocalizes from bud neck to cytoplasm upon replication stress" /codon_start=1 /product="Aim44p" /protein_id="DAA11276.1" /db_xref="SGD:S000006079" /translation="MIIRAPIRTKTKSFRGDQMDFKFPSNESLPRGTLEEYHLNNHHL LNDVFAAENGVSRDEDGNSQTLSDYTSTSNTNTNSGYSSNGYYSFANISDNTTSSPRI VINQNETARLTSSDSNKSDFFASHDFPGNDSLHYSSSNVVKNQLHSMEAIPEGNITGS ISTAFQTIPTADNVSYDIAPSSASSLLPRKSTSKSAILPSTQEAKPMTKLNMEKDIKT IELNNSVVPKPKKKLNRVPTIRRVESSRFSNSRYSSSVSSKSSSSRCSLKRSKAIRCK GGLLYYFTSLGIKIKKKLRKLRLVLRRRLFSYNVQKVPSATNSKTTKSKANINNKSKK RGTNLVNKNSNSTPRQKKSQRYVSNLQRSISSKSLVPVLAPQKKTKPLTVDTKFKANH PQSEDSKVGSNTPRSPLVSYTPSLRRTNSSIRRAASILTASATMTPANNKNSFISVPD NVSHAVTRNSSMYSRSRLVRSKPSTALNAIARQPSIVVENKVIPLSMNRYSIKEEDEY VIDTSSMRELSPVNSVCSSDYDRESSESYSNYADAMETTEVDNKDRVECNNEIQNVDA NNEETSNEESYNLMKHYLSTVIAQRIMLRVQIARIQNYKSNVVYMNKSAETNSTIYED LVDSLLTEYEADGSSSQIFDGVTVRADEEEEEDEDDEDDEEEEEENDDEEDEEDEEDD EDDEEEEEKRKEGEGRNLAKEVDELAELSPMRKQSDLSITLRSPFAMLNPAYSNSIIS LPTGVVKRSLTLPVGMKI" gene 254814..255761 /gene="TGS1" /locus_tag="YPL157W" mRNA 254814..255761 /gene="TGS1" /locus_tag="YPL157W" /product="RNA methyltransferase" CDS 254814..255761 /gene="TGS1" /locus_tag="YPL157W" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11983179]" /experiment="EXISTENCE:mutant phenotype:GO:0001510 RNA methylation [PMID:11983179]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:27348091]" /experiment="EXISTENCE:mutant phenotype:GO:0008173 RNA methyltransferase activity [PMID:11983179]" /experiment="EXISTENCE:mutant phenotype:GO:0017126 nucleologenesis [PMID:15340060]" /experiment="EXISTENCE:mutant phenotype:GO:0032210 regulation of telomere maintenance via telomerase [PMID:18840651|PMID:18273059]" /experiment="EXISTENCE:mutant phenotype:GO:0036261 7-methylguanosine cap hypermethylation [PMID:11983179]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:21398639]" /note="Trimethyl guanosine synthase, conserved nucleolar methyl transferase; converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs; interacts with Swm2p, which may confer substrate specificity on Tgs1p" /codon_start=1 /product="RNA methyltransferase" /protein_id="DAA11277.1" /db_xref="SGD:S000006078" /translation="MGRTFIHASKIKHAARKRKHHSNFRTLIKLLNNDAYKIESSKPL KNGKLFKYWKNRRRLFSKIDSASIYMTDELWFSVTPERIACFLANFVKACMPNAERIL DVFCGGGGNTIQFAMQFPYVYGVDYSIEHIYCTAKNAQSYGVDDRIWLKRGSWKKLVS KQKLSKIKYDCVFGSPPWGGPEYLRNDVYDLEQHLKPMGITKMLKSFLKLSPNVIMFL PRNSDLNQLSRATRKVLGPFAKCKVLYVKENGYMKGIFCMWGECFFNYEPASTENSRR ESSEKEELSSENEELSKRKKHESTTTTKDNTVDIYDVNG" gene complement(255913..256767) /gene="PRM4" /locus_tag="YPL156C" mRNA complement(255913..256767) /gene="PRM4" /locus_tag="YPL156C" /product="pheromone-regulated protein PRM4" CDS complement(255913..256767) /gene="PRM4" /locus_tag="YPL156C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift" /codon_start=1 /product="pheromone-regulated protein PRM4" /protein_id="DAA11278.1" /db_xref="SGD:S000006077" /translation="MIADSSVLKKHTAIKRSTRIISLTLVLLGVFSFLLLTWNDSLEF YNSADPSENKKNSEEESEKKFVYKLPNLLKTADSFLSNENELNFQKVKEEISNIQSEV EVDIPEPSSKATSKFSSRSFQTDNVVTATTTTTLNPRSSSLALQKNCDHKKFDPRTDF LDIIRTSPAVLFIKSSQADSIFLKNLLQREFEISPELATVDLEKHSHGYELEKYIKQN KLNIDTSAALESIQSPYLFLNGISVINRGMVRDIIEPHSKGLLLPLLKSEARGNLLVE KKDIPSNS" gene complement(257216..259336) /gene="KIP2" /locus_tag="YPL155C" mRNA complement(257216..259336) /gene="KIP2" /locus_tag="YPL155C" /product="Kip2p" CDS complement(257216..259336) /gene="KIP2" /locus_tag="YPL155C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:31490122]" /experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:9693366]" /experiment="EXISTENCE:direct assay:GO:0007018 microtubule-based movement [PMID:31490122]" /experiment="EXISTENCE:direct assay:GO:0007026 negative regulation of microtubule depolymerization [PMID:26576948]" /experiment="EXISTENCE:direct assay:GO:0015631 tubulin binding [PMID:37093124]" /experiment="EXISTENCE:direct assay:GO:0046785 microtubule polymerization [PMID:37093124|PMID:26576948]" /experiment="EXISTENCE:direct assay:GO:0061863 microtubule plus end polymerase [PMID:26576948|PMID:37093124]" /experiment="EXISTENCE:direct assay:GO:1903754 cortical microtubule plus-end [PMID:15177030|PMID:18411245]" /experiment="EXISTENCE:genetic interaction:GO:0008574 plus-end-directed microtubule motor activity [PMID:15177030|PMID:18411245]" /experiment="EXISTENCE:mutant phenotype:GO:0007026 negative regulation of microtubule depolymerization [PMID:37093124|PMID:9693366]" /experiment="EXISTENCE:mutant phenotype:GO:0008574 plus-end-directed microtubule motor activity [PMID:15177030]" /experiment="EXISTENCE:mutant phenotype:GO:0015631 tubulin binding [PMID:37093124]" /experiment="EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:9693366]" /experiment="EXISTENCE:mutant phenotype:GO:0046785 microtubule polymerization [PMID:37093124]" /experiment="EXISTENCE:mutant phenotype:GO:0061863 microtubule plus end polymerase [PMID:37093124]" /note="Kinesin-related motor protein and plus-end directed microtubule (MT) polymerase; involved in mitotic spindle positioning, nuclear migration, microtubule polymerization and inhibition of MT catastrophe; stabilizes microtubules by targeting Bik1p to the MT plus end; Kip2p levels are controlled during the cell cycle" /codon_start=1 /product="Kip2p" /protein_id="DAA11279.1" /db_xref="SGD:S000006076" /translation="MIQKMSPSLRRPSTRSSSGSSNIPQSPSVRSTSSFSNLTRNSIR STSNSGSQSISASSTRSNSPLRSVSAKSDPFLHPGRIRIRRSDSINNNSRKNDTYTGS ITVTIRPKPRSVGTSRDHVGLKSPRYSQPRSNSHHGSNTFVRDPWFITNDKTIVHEEI GEFKFDHVFASHCTNLEVYERTSKPMIDKLLMGFNATIFAYGMTGSGKTFTMSGNEQE LGLIPLSVSYLFTNIMEQSMNGDKKFDVIISYLEIYNERIYDLLESGLEESGSRISTP SRLYMSKSNSNGLGVELKIRDDSQYGVKVIGLTERRCESSEELLRWIAVGDKSRKIGE TDYNARSSRSHAIVLIRLTSTNVKNGTSRSSTLSLCDLAGSERATGQQERRKEGSFIN KSLLALGTVISKLSADKMNSVGSNIPSPSASGSSSSSGNATNNGTSPSNHIPYRDSKL TRLLQPALSGDSIVTTICTVDTRNDAAAETMNTLRFASRAKNVALHVSKKSIISNGNN DGDKDRTIELLRRQLEEQRRMISELKNRSNIGEPLTKSSNESTYKDIKATGNDGDPNL ALMRAENRVLKYKLENCEKLLDKDVVDLQDSEIMEIVEMLPFEVGTLLETKFQGLESQ IRQYRKYTQKLEDKIMALEKSGHTAMSLTGCDGTEVIELQKMLERKDKMIEALQSAKR LRDRALKPLINTQQSPHPVVDNDK" gene complement(259714..260931) /gene="PEP4" /locus_tag="YPL154C" /gene_synonym="PHO9" /gene_synonym="PRA1" /gene_synonym="yscA" mRNA complement(259714..260931) /gene="PEP4" /locus_tag="YPL154C" /gene_synonym="PHO9" /gene_synonym="PRA1" /gene_synonym="yscA" /product="proteinase A" CDS complement(259714..260931) /gene="PEP4" /locus_tag="YPL154C" /gene_synonym="PHO9" /gene_synonym="PRA1" /gene_synonym="yscA" /EC_number="3.4.23.25" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:23708375|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008233 peptidase activity [PMID:7002931]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:31332264]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:23382696]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:29514932]" /experiment="EXISTENCE:mutant phenotype:GO:0016237 microautophagy [PMID:12529432]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0051603 proteolysis involved in protein catabolic process [PMID:16183335]" /note="Vacuolar aspartyl protease (proteinase A); required for post-translational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; plays a protective role in acetic acid induced apoptosis; synthesized as a zymogen, self-activates; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway" /codon_start=1 /product="proteinase A" /protein_id="DAA11280.1" /db_xref="SGD:S000006075" /translation="MFSLKALLPLALLLVSANQVAAKVHKAKIYKHELSDEMKEVTFE QHLAHLGQKYLTQFEKANPEVVFSREHPFFTEGGHDVPLTNYLNAQYYTDITLGTPPQ NFKVILDTGSSNLWVPSNECGSLACFLHSKYDHEASSSYKANGTEFAIQYGTGSLEGY ISQDTLSIGDLTIPKQDFAEATSEPGLTFAFGKFDGILGLGYDTISVDKVVPPFYNAI QQDLLDEKRFAFYLGDTSKDTENGGEATFGGIDESKFKGDITWLPVRRKAYWEVKFEG IGLGDEYAELESHGAAIDTGTSLITLPSGLAEMINAEIGAKKGWTGQYTLDCNTRDNL PDLIFNFNGYNFTIGPYDYTLEVSGSCISAITPMDFPEPVGPLAIVGDAFLRKYYSIY DLGNNAVGLAKAI" rep_origin 260931..261727 /note="ARS1612; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay" /db_xref="SGD:S000130198" gene complement(261727..264192) /gene="RAD53" /locus_tag="YPL153C" /gene_synonym="LSD1" /gene_synonym="MEC2" /gene_synonym="SPK1" mRNA complement(261727..264192) /gene="RAD53" /locus_tag="YPL153C" /gene_synonym="LSD1" /gene_synonym="MEC2" /gene_synonym="SPK1" /product="serine/threonine/tyrosine protein kinase RAD53" CDS complement(261727..264192) /gene="RAD53" /locus_tag="YPL153C" /gene_synonym="LSD1" /gene_synonym="MEC2" /gene_synonym="SPK1" /EC_number="2.7.12.1" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16816422]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004712 protein serine/threonine/tyrosine kinase activity [PMID:8355715|PMID:30377154]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:8355715]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:genetic interaction:GO:0000077 DNA damage checkpoint signaling [PMID:7926756]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:16816422]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:8355715]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 protein localization [PMID:18045534]" /experiment="EXISTENCE:mutant phenotype:GO:0009202 deoxyribonucleoside triphosphate biosynthetic process [PMID:17188244]" /experiment="EXISTENCE:mutant phenotype:GO:0042326 negative regulation of phosphorylation [PMID:24130507]" /experiment="EXISTENCE:mutant phenotype:GO:0043247 telomere maintenance in response to DNA damage [PMID:24130507]" /note="DNA damage response kinase; signal transduction pathway component required for DNA damage and replication checkpoints, promoting cell cycle arrest and DNA repair; role in initiation of DNA replication; inhibits gene gating through NPC protein phosphorylation, to promote fork stability; activates downstream kinase Dun1p; senses mtDNA depletion and mitochondrial ROS; relocalizes to cytosol under hypoxia; contains two FHA domains; human homolog CHEK2 implicated in breast cancer complements the null" /codon_start=1 /product="serine/threonine/tyrosine protein kinase RAD53" /protein_id="DAA11281.1" /db_xref="SGD:S000006074" /translation="MENITQPTQQSTQATQRFLIEKFSQEQIGENIVCRVICTTGQIP IRDLSADISQVLKEKRSIKKVWTFGRNPACDYHLGNISRLSNKHFQILLGEDGNLLLN DISTNGTWLNGQKVEKNSNQLLSQGDEITVGVGVESDILSLVIFINDKFKQCLEQNKV DRIRSNLKNTSKIASPGLTSSTASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIER TTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFYEDTESYYMVMEFV SGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVL VKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMW SMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVD PNNRSTAAKALNHPWIKMSPLGSQSYGDFSQISLSQSLSQQKLLENMDDAQYEFVKAQ RKLQMEQQLQEQDQEDQDGKIQGFKIPAHAPIRYTQPKSIEAETREQKLLHSNNTENV KSSKKKGNGRFLTLKPLPDSIIQESLEIQQGVNPFFIGRSEDCNCKIEDNRLSRVHCF IFKKRHAVGKSMYESPAQGLDDIWYCHTGTNVSYLNNNRMIQGTKFLLQDGDEIKIIW DKNNKFVIGFKVEINDTTGLFNEGLGMLQEQRVVLKQTAEEKDLVKKLTQMMAAQRAN QPSASSSSMSAKKPPVSDTNNNGNNSVLNDLVESPINANTGNILKRIHSVSLSQSQID PSKKVKRAKLDQTSKGPENLQFS" gene 264602..264700 /locus_tag="YPL152W-A" mRNA 264602..264700 /locus_tag="YPL152W-A" /product="hypothetical protein" CDS 264602..264700 /locus_tag="YPL152W-A" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11282.1" /db_xref="SGD:S000028721" /translation="MMVHLTLKSHLIKEELLWHALSPSYSCRYHGR" gene 265028..266104 /gene="RRD2" /locus_tag="YPL152W" /gene_synonym="YPA2" mRNA 265028..266104 /gene="RRD2" /locus_tag="YPL152W" /gene_synonym="YPA2" /product="peptidylprolyl isomerase RRD2" CDS 265028..266104 /gene="RRD2" /locus_tag="YPL152W" /gene_synonym="YPA2" /EC_number="5.2.1.8" /experiment="EXISTENCE:direct assay:GO:0000159 protein phosphatase type 2A complex [PMID:17550305]" /experiment="EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:16380387]" /experiment="EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:10660069]" /experiment="EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:11262194]" /experiment="EXISTENCE:mutant phenotype:GO:0019888 protein phosphatase regulator activity [PMID:12952889]" /note="Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="peptidylprolyl isomerase RRD2" /protein_id="DAA11283.1" /db_xref="SGD:S000006073" /translation="MLPEKRLLTPDDMKLWEESPTRAHFTKFIIDLAESVKGHENSQY KEPISESINSMMNLLSQIKDITQKHPVIKDADSSRFGKVEFRDFYDEVSRNSRKILRS EFPSLTDEQLEQLSIYLDESWGNKRRIDYGSGHELNFMCLLYGLYSYGIFNLSNDSTN LVLKVFIEYLKIMRILETKYWLEPAGSHGVWGLDDYHFLPFLFGAFQLTTHKHLKPIS IHNNELVEMFAHRYLYFGCIAFINKVKSSASLRWHSPMLDDISGVKTWSKVAEGMIKM YKAEVLSKLPIMQHFYFSEFLPCPDGVSPPRGHIHDGTDKDDECNFEGHVHTTWGDCC GIKLPSAIAATEMNKKHHKPIPFD" gene complement(266180..267535) /gene="PRP46" /locus_tag="YPL151C" /gene_synonym="NTC50" mRNA complement(266180..267535) /gene="PRP46" /locus_tag="YPL151C" /gene_synonym="NTC50" /product="mRNA splicing protein PRP46" CDS complement(266180..267535) /gene="PRP46" /locus_tag="YPL151C" /gene_synonym="NTC50" /experiment="EXISTENCE:direct assay:GO:0005681 spliceosomal complex [PMID:11884590]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:12554883]" /experiment="EXISTENCE:physical interaction:GO:0000974 Prp19 complex [PMID:12088152]" /note="Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs" /codon_start=1 /product="mRNA splicing protein PRP46" /protein_id="DAA11284.1" /db_xref="SGD:S000006072" /translation="MDGNDHKVENLGDVDKFYSRIRWNNQFSYMATLPPHLQSEMEGQ KSLLMRYDTYRKESSSFSGEGKKVTLQHVPTDFSEASQAVISKKDHDTHASAFVNKIF QPEVAEELIVNRYEKLLSQRPEWHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSN DTTMKVWDLATGKLKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIR DYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTP VDPQVVSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVASACTDDIRSW GLAEGSLLTNFESEKTGIINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREM VGSLEGERSVLCSTFDKTGLRLITGEADKSIKIWKQDETATKESEPGLAWNPNLSAKR F" gene 268188..270893 /locus_tag="YPL150W" mRNA 268188..270893 /locus_tag="YPL150W" /product="non-specific serine/threonine protein kinase" CDS 268188..270893 /locus_tag="YPL150W" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0006468 protein phosphorylation [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0036464 cytoplasmic ribonucleoprotein granule [PMID:25342717]" /note="Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study" /codon_start=1 /product="non-specific serine/threonine protein kinase" /protein_id="DAA11285.1" /db_xref="SGD:S000006071" /translation="MVNPVGSSKLEQNNIKSIIGSSYNRLYSQFTSDELTEVGNYKIL KQIGEGSFGKVYLALHRPTHRKVCLKTSDKNDPNIVREVFYHRQFDFPYITKLYEVIV TESKVWMALEYCPGKELYDHLLSLRRISLLECGELFAQISGAVYYAHSMHCVHRDLKL ENILLDKNGNAKLTDFGFTRECMTKTTLETVCGTTVYMAPELIERRTYDGFKIDIWSL GVILYTLITGYLPFDDDDEAKTKWKIVNEEPKYDAKVIPDDARDLISRLLAKNPGERP SLSQVLRHPFLQPYGSVVLDQTQKILCRQRSGGTQFKSKLERRLLKRLKQSGVDTQAI KQSILKKKCDSLSGLWLLLLAQGKKQENCKYPKRSRSVLSVKKVIESATHNDTNGISE DVLKPSLELSRAASLSKMLNKGSDFVTSMTPVSRKKSKDSAKVLNPTLSKISSQRAYS HSIAGSPRKSNNFLQKVSSFFKSKKSSNSNSNNSIHTNVSESLIASNRGAPSSGSFLK KNSGSIQKSRTDTVANPSRTESIGSLNENVAGAIVPRSANNTTLENKKTSGNEIGLKV APELLLNEHIRIEEPRLKRFKSSISSEISQTSTGNYDSESAENSRSISFDGKVSPPPI RNRPLSEISQISNDTYISEYSTDGNNSSFKISDTIKPSYIRKGSETTSQYSASSEKMT NGYGRKFVRRDLSIVSTASSTSERSSRTDSFYDITTATPVVTTDNRRNKNNNLKESVL PRFGTQRPWTGKRTYTTSRHGKNARRSSKRGLFKITSSNTDSIIQEVSSSEEEDHNVI YSKGKGLPTPVLQTKGLIENGLNERDEEGDDEYAIHTDGEFSIKPQFSDDVIDKQNHL PSVKAVATKRSLSEGSNWSSSYLDSDNNRRRVSSLLVEDGGNPTA" regulatory 271236..271277 /regulatory_class="other" /note="One of four upstream open reading frames (uORFs) in 5' untranslated region of ATG5 gene, regulate translation" regulatory 271252..271302 /regulatory_class="other" /note="One of four upstream open reading frames (uORFs) in 5' untranslated region of ATG5 gene, regulate translation" regulatory 271299..271307 /regulatory_class="other" /note="One of four upstream open reading frames (uORFs) in 5' untranslated region of ATG5 gene, regulate translation" regulatory 271302..271307 /regulatory_class="other" /note="One of four upstream open reading frames (uORFs) in 5' untranslated region of ATG5 gene, regulate translation" gene 271310..272194 /gene="ATG5" /locus_tag="YPL149W" /gene_synonym="APG5" mRNA 271310..272194 /gene="ATG5" /locus_tag="YPL149W" /gene_synonym="APG5" /product="Atg5p" CDS 271310..272194 /gene="ATG5" /locus_tag="YPL149W" /gene_synonym="APG5" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:18497569|PMID:11689437]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005776 autophagosome [PMID:15155809]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:11897782]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:23503366]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:23064152]" /experiment="EXISTENCE:direct assay:GO:0019776 Atg8-family ligase activity [PMID:17986448]" /experiment="EXISTENCE:direct assay:GO:0034274 Atg12-Atg5-Atg16 complex [PMID:11897782]" /experiment="EXISTENCE:direct assay:GO:0061908 phagophore [PMID:23549786]" /experiment="EXISTENCE:direct assay:GO:0120095 vacuole-isolation membrane contact site [PMID:23549786]" /experiment="EXISTENCE:direct assay:GO:0140355 cargo receptor ligand activity [PMID:27879200]" /experiment="EXISTENCE:mutant phenotype:GO:0000423 mitophagy [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:32788210|PMID:8921905]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:10712513]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /experiment="EXISTENCE:mutant phenotype:GO:0051365 cellular response to potassium ion starvation [PMID:32788210]" /note="Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3 by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; also involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner" /codon_start=1 /product="Atg5p" /protein_id="DAA11286.1" /db_xref="SGD:S000006070" /translation="MNDIKQLLWNGELNVLVSIDPSFLMKGSPREIAVLRIRVPRETY LVNYMPLIWNKIKSFLSFDPLTDSEKYFWFEHNKTPIPWNYPVGVLFDCLAGKSATFT TSFENQVKDVLTFLRIHLVMGDSLPPTIIPIASSKTQAEKFWFHQWKQVCFILNGSSK AIMSLSVNEARKFWGSVITRNFQDFIEISNKISSSRPRHIPLIIQTSRTSGTFRISQP TISMTGVNPTLKDIEGDILDVKEGINGNDVMVICQGIEIPWHMLLYDLYSKLRSFDGF LYITLVPIKGGDKASSEL" gene complement(272294..272815) /gene="PPT2" /locus_tag="YPL148C" mRNA complement(272294..272815) /gene="PPT2" /locus_tag="YPL148C" /product="holo-[acyl-carrier-protein] synthase" CDS complement(272294..272815) /gene="PPT2" /locus_tag="YPL148C" /EC_number="2.7.8.7" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0008897 holo-[acyl-carrier-protein] synthase activity [PMID:9712852]" /experiment="EXISTENCE:direct assay:GO:0031108 holo-[acyl-carrier-protein] biosynthetic process [PMID:9712852]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:9712852]" /note="Phosphopantetheine:protein transferase (PPTase); activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation" /codon_start=1 /product="holo-[acyl-carrier-protein] synthase" /protein_id="DAA11287.1" /db_xref="SGD:S000006069" /translation="MSFASRNIGRKIAGVGVDIVYLPRFAHILEKYSPFDPCGRSTLN KITRKFMHEKERFHFSNLLIEENCLTPRLHEYIAGVWALKECSLKALCCCVSKHDLPP AQVLYAGMLYKTQTDTGVPQLEFDKMFGKKYPKYQQLSKNYDSLFSTHEFLVSLSHDK DYLIAVTNLVERE" gene 273255..275867 /gene="PXA1" /locus_tag="YPL147W" /gene_synonym="LPI1" /gene_synonym="PAL1" /gene_synonym="PAT2" /gene_synonym="SSH2" mRNA 273255..275867 /gene="PXA1" /locus_tag="YPL147W" /gene_synonym="LPI1" /gene_synonym="PAL1" /gene_synonym="PAT2" /gene_synonym="SSH2" /product="ATP-binding cassette long-chain fatty acid transporter PXA1" CDS 273255..275867 /gene="PXA1" /locus_tag="YPL147W" /gene_synonym="LPI1" /gene_synonym="PAL1" /gene_synonym="PAT2" /gene_synonym="SSH2" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:35127709|PMID:8670886]" /experiment="EXISTENCE:direct assay:GO:0015867 ATP transport [PMID:35127709]" /experiment="EXISTENCE:direct assay:GO:0042626 ATPase-coupled transmembrane transporter activity [PMID:35127709]" /experiment="EXISTENCE:mutant phenotype:GO:0015908 fatty acid transport [PMID:8670886]" /experiment="EXISTENCE:mutant phenotype:GO:0042626 ATPase-coupled transmembrane transporter activity [PMID:8670886]" /note="Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" /codon_start=1 /product="ATP-binding cassette long-chain fatty acid transporter PXA1" /protein_id="DAA11288.1" /db_xref="SGD:S000006068" /translation="MSTTLAAPAKLKSLLLNLHTHCIGLHVNDVTPKVYFKLLIRHLL QISRSNAAHPKLRRRAQILLVSLFLSGVTLFSGVTYSTFKIILKCYKFYKFPWKRRNR RPLIRRTRSQMQLDSGARIMYIPEVELVDRQSPDDNKFMNATDKKKRKRIFIPPKDND VYEHDKFLFKNVELERAKNSQLFYSKFLNQMNVLSKILIPTVFDKNFLLLTAQIFFLV MRTWLSLFVAKLDGQIVKNIIAGRGRSFLWDLGCWFLIAVPASYTNSAIKLLQRKLSL NFRVNLTRYIHDMYLDKRLTFYKLIFDAKASNSVIKNIDNSITNDVAKFCDATCSVFA NIAKPVIDLIFFSVYLRDNLGTVGVAGIFVNYFITGFILRKYTPPLGKLAGERSASDG DYYNYHLNMINNSEEIAFYQGTAVERTKVKELYDVLMEKMLLVDKVKFGYNMLEDYVL KYTWSGLGYVFASIPIVMSTLATGINSEEKNMKEFIVNKRLMLSLADAGSRLMHSIKD ISQLTGYTNRIFTLLSVLHRVHSLNFNYGAVPSILSIRTEDASRNSNLLPTTDNSQDA IRGTIQRNFNGIRLENIDVIIPSVRASEGIKLINKLTFQIPLHIDPITSKSNSIQDLS KANDIKLPFLQGSGSSLLILGPNGCGKSSIQRIIAEIWPVYNKNGLLSIPSENNIFFI PQKPYFSRGGTLRDQIIYPMSSDEFFDRGFRDKELVQILVEVKLDYLLKRGVGLTYLD AIADWKDLLSGGEKQRVNFARIMFHKPLYVVLDEATNAISVDMEDYLFNLLKRYRFNF ISISQRPTLIKYHEMLLEIGENRDGKWQLQAVGTDEAITSIDNEIEELERKLERVKGW EDERTKLREKLEII" gene complement(276162..277529) /gene="NOP53" /locus_tag="YPL146C" mRNA complement(276162..277529) /gene="NOP53" /locus_tag="YPL146C" /product="Nop53p" CDS complement(276162..277529) /gene="NOP53" /locus_tag="YPL146C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16043506|PMID:11914276|PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10684247|PMID:16043506]" /experiment="EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:16128814]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:16043506]" /experiment="EXISTENCE:mutant phenotype:GO:0000176 nuclear exosome (RNase complex) [PMID:31662437]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15686447]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:16128814]" /note="Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p and with the nucleolar proteins Nop17p and Nip7p; null mutant is viable but growth is severely impaired" /codon_start=1 /product="Nop53p" /protein_id="DAA11289.1" /db_xref="SGD:S000006067" /translation="MAPTNLTKKPSQYKQSSRKGKKAWRKNIDLSDVEQYMEKKIDHE ITHGTSDITSLQNDALFHVDVEGDEILKNKLIKRKQIKKVLKSKEILDAVKTNSKIAA LNHHKNSSGNPNKIQGVSKHELKKLMALAGRVHGESKIKNRVAKDGLVKTTAGDLWGE ESNSKKQKVKLPSGIKLDVEKKDQIPEELLKKSTTSWSTASVRPSTLDIEPIAVKEFT EIPHAGKSYNPNNKAWSELINKEYKEEKAREDERIALEKYKERIRHLMETLDDNEEEE SSSNEEEEEEEEENENENESTQCSGSDKEIKLSINKPVKNKKKTKYQRNKAKRHEEKV KLQQELKELRQRVKDLEEVINSEETEILSAIESDSNKVKKSKKNKKHKLGTKYSVIDE RLEIKFSDELSDSLRKLKPEGNLLYDTVRKLQSSGKVETRVPVRKGRKYKQKITEKWT HKDFK" gene complement(278395..279699) /gene="KES1" /locus_tag="YPL145C" /gene_synonym="BSR3" /gene_synonym="LPI3" /gene_synonym="OSH4" mRNA complement(278395..279699) /gene="KES1" /locus_tag="YPL145C" /gene_synonym="BSR3" /gene_synonym="LPI3" /gene_synonym="OSH4" /product="oxysterol-binding protein KES1" CDS complement(278395..279699) /gene="KES1" /locus_tag="YPL145C" /gene_synonym="BSR3" /gene_synonym="LPI3" /gene_synonym="OSH4" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:11916983]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8978672|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0015918 sterol transport [PMID:16585271|PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:20729555]" /experiment="EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:20729555]" /experiment="EXISTENCE:direct assay:GO:0120015 sterol transfer activity [PMID:20008566]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:17004323]" /experiment="EXISTENCE:genetic interaction:GO:0006892 post-Golgi vesicle-mediated transport [PMID:8978672|PMID:11916983]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:15173322]" /experiment="EXISTENCE:genetic interaction:GO:0015918 sterol transport [PMID:16585271]" /experiment="EXISTENCE:genetic interaction:GO:0030011 maintenance of cell polarity [PMID:17004323]" /experiment="EXISTENCE:genetic interaction:GO:0034727 piecemeal microautophagy of the nucleus [PMID:15367582]" /experiment="EXISTENCE:mutant phenotype:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:11916983]" /experiment="EXISTENCE:mutant phenotype:GO:0006665 sphingolipid metabolic process [PMID:23593226]" /experiment="EXISTENCE:mutant phenotype:GO:0008142 oxysterol binding [PMID:16136145]" /experiment="EXISTENCE:mutant phenotype:GO:0008289 lipid binding [PMID:20008566]" /experiment="EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:20008566]" /experiment="EXISTENCE:mutant phenotype:GO:0035621 ER to Golgi ceramide transport [PMID:24213531]" /experiment="EXISTENCE:mutant phenotype:GO:0120015 sterol transfer activity [PMID:20008566]" /note="Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger; one of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication" /codon_start=1 /product="oxysterol-binding protein KES1" /protein_id="DAA11290.1" /db_xref="SGD:S000006066" /translation="MSQYASSSSWTSFLKSIASFNGDLSSLSAPPFILSPISLTEFSQ YWAEHPELFLEPSFINDDNYKEHCLIDPEVESPELARMLAVTKWFISTLKSQYCSRNE SLGSEKKPLNPFLGELFVGKWENKEHPEFGETVLLSEQVSHHPPVTAFSIFNDKNKVK LQGYNQIKASFTKSLMLTVKQFGHTMLDIKDESYLVTPPPLHIEGILVASPFVELEGK SYIQSSTGLLCVIEFSGRGYFSGKKNSFKARIYKDSKDSKDKEKALYTISGQWSGSSK IIKANKKEESRLFYDAARIPAEHLNVKPLEEQHPLESRKAWYDVAGAIKLGDFNLIAK TKTELEETQRELRKEEEAKGISWQRRWFKDFDYSVTPEEGALVPEKDDTFLKLASALN LSTKNAPSGTLVGDKEDRKEDLSSIHWRFQRELWDEEKEIVL" gene 280480..280926 /gene="POC4" /locus_tag="YPL144W" /gene_synonym="DMP1" /gene_synonym="PBA4" mRNA 280480..280926 /gene="POC4" /locus_tag="YPL144W" /gene_synonym="DMP1" /gene_synonym="PBA4" /product="Poc4p" CDS 280480..280926 /gene="POC4" /locus_tag="YPL144W" /gene_synonym="DMP1" /gene_synonym="PBA4" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17707236]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17707236|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0051131 chaperone-mediated protein complex assembly [PMID:17707236]" /experiment="EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:18278055|PMID:18260085]" /experiment="EXISTENCE:mutant phenotype:GO:0051131 chaperone-mediated protein complex assembly [PMID:17707236]" /experiment="EXISTENCE:physical interaction:GO:0051131 chaperone-mediated protein complex assembly [PMID:18278055]" /note="Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam)" /codon_start=1 /product="Poc4p" /protein_id="DAA11291.1" /db_xref="SGD:S000006065" /translation="MLVKTISRTIESESGFLQPTLDVIATLPADDRSKKIPISLVVGF KQEASLNSSSSLSCYYYAIPLMRDRHINLKSGGSNVVGIPLLDTKDDRIRDMARHMAT IISERFNRPCYVTWSSLPSEDPSMLVANHLYILKKCLDLLKTELGE" gene complement(281056..281517) /gene="SNR17B" /locus_tag="YNCP0005C" ncRNA complement(281056..281517) /ncRNA_class="snoRNA" /gene="SNR17B" /locus_tag="YNCP0005C" /product="SNR17B" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:3327689]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:8455623|PMID:3327689]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:15231838|PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0031428 box C/D methylation guide snoRNP complex [PMID:10094313]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:genetic interaction:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:7556076]" /experiment="EXISTENCE:genetic interaction:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:7556076]" /experiment="EXISTENCE:genetic interaction:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:7556076]" /experiment="EXISTENCE:genetic interaction:GO:0003723 RNA binding [PMID:7556076]" /experiment="EXISTENCE:genetic interaction:GO:0019843 rRNA binding [PMID:7556076]" /experiment="EXISTENCE:mutant phenotype:GO:0019843 rRNA binding [PMID:7556076]" /experiment="EXISTENCE:physical interaction:GO:0003723 RNA binding [PMID:3327689]" /experiment="EXISTENCE:physical interaction:GO:0031428 box C/D methylation guide snoRNP complex [PMID:10733567]" /note="Small nucleolar RNA (snoRNA) U3; part of small (ribosomal) subunit (SSU) processome; SNR17A also encodes snoRNA U3" /db_xref="SGD:S000007441" gene 282122..282970 /gene="RPL33A" /locus_tag="YPL143W" /gene_synonym="GCD17" /gene_synonym="RPL37A" mRNA join(282122..282140,282666..282970) /gene="RPL33A" /locus_tag="YPL143W" /gene_synonym="GCD17" /gene_synonym="RPL37A" /product="ribosomal 60S subunit protein L33A" CDS join(282122..282140,282666..282970) /gene="RPL33A" /locus_tag="YPL143W" /gene_synonym="GCD17" /gene_synonym="RPL37A" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:17548477]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:17548477]" /note="Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication" /codon_start=1 /product="ribosomal 60S subunit protein L33A" /protein_id="DAA11292.1" /db_xref="SGD:S000006064" /translation="MAESHRLYVKGKHLSYQRSKRVNNPNVSLIKIEGVATPQDAQFY LGKRIAYVYRASKEVRGSKIRVMWGKVTRTHGNSGVVRATFRNNLPAKTFGASVRIFL YPSNI" gene complement(283464..286061) /gene="FRK1" /locus_tag="YPL141C" mRNA complement(283464..286061) /gene="FRK1" /locus_tag="YPL141C" /product="protein kinase FRK1" CDS complement(283464..286061) /gene="FRK1" /locus_tag="YPL141C" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22289182|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0000011 vacuole inheritance [PMID:37509134]" /experiment="EXISTENCE:genetic interaction:GO:0045033 peroxisome inheritance [PMID:37509134]" /note="Protein kinase; minor role relative to Kin4p in regulating peroxisomal transport and vacuolar inheritance; protects the peroxisomal Myo2p receptor Inp2p from degradation in mother cells along with Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication" /codon_start=1 /product="protein kinase FRK1" /protein_id="DAA11293.1" /db_xref="SGD:S000006062" /translation="MSYTNKRHTYYGGFTNDLSDTFQYPQRTDEQRRKHVTFGPYILG STLGEGEFGKVKLGWPKNFSNSSNSTFDFPKQVAIKLIKRDSISNDYRKEVKIYREIN ALKHLSHPNIVKLEEVLQNSRYIGIVLEYACGGEFYKYIQKKRRLKEMNACRLFSQLI SGVHYIHSKGLVHRDLKLENLLLDKNENLVITDFGFVNEFCSRNELMKTSCGSPCYAA PELVISAEPYEARKADIWSCGVILYAILAGYLPWDDDPNNPEGSDIGRLYNYINSTPL KFPDYILPIPRDLLRRMLVSDPKKRINLKQIKKHEWLKPHSSFLSITPDEWDKLNNTQ SVFRLAKPRRRYGSRPQSSCSTSSLGSRSDKRDSLVIDSTLITFPAPPQESQNHIITR PASIASDQRLSPIRRSNRHNRSNSAASVALQAVVNADREYVLSHEQSLSPVQNIRQTT GNMTASLSPPPAISPGDIIIETTPIKRNTISGSSIVPSLEEESSTTMQTSKIQPNNMA SSQNHQYNKNKTQNSLQSAKNFYRTSSSSHTKPRPTSYHPGSYTTPPYNSNTLSIYEI NEKAKSSASSQTLNQRDTSPFDSTPYLALDTCITSSSSIESSPKLITHGQFSVAKPSV DLQSVSGDLIKYKRDADVVTRIYDEKYKQKRKSLRYSGIFSDISCDTVTEESDELRPP ESPLQQHEGQESIDKAKTEDTSEKGSKSSNIAKATAQKHVNNHLERSLNEAESTKKRF SFLSLYSYDTSKSSLYSSMDSKRKPSPPSQRRPKKDDSYQTNSKNHYITASNMQTSHQ VSKDLPAPTMVQNKCTLETKKAVRSNRSSIMVSEVNKASVDNKAAQSPEHSTAKRVLG FFKRRSMKI" gene complement(287514..289034) /gene="MKK2" /locus_tag="YPL140C" /gene_synonym="LPI6" /gene_synonym="SSP33" mRNA complement(287514..289034) /gene="MKK2" /locus_tag="YPL140C" /gene_synonym="LPI6" /gene_synonym="SSP33" /product="putative mitogen-activated protein kinase kinase MKK2" CDS complement(287514..289034) /gene="MKK2" /locus_tag="YPL140C" /gene_synonym="LPI6" /gene_synonym="SSP33" /EC_number="2.7.12.2" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12361575]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12361575]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12361575]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12361575]" /experiment="EXISTENCE:genetic interaction:GO:0000196 cell integrity MAPK cascade [PMID:8386320]" /experiment="EXISTENCE:genetic interaction:GO:0000425 pexophagy [PMID:20385774]" /experiment="EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:8386320]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:8386320]" /note="MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication" /codon_start=1 /product="putative mitogen-activated protein kinase kinase MKK2" /protein_id="DAA11294.1" /db_xref="SGD:S000006061" /translation="MASMFRPPESNRSHQKTPKLTLPVNLVQNAKSTNDGQHLNRSPY SSVNESPYSNNSTSATSTTSSMASNSTLLYNRSSTTTIKNRPVPPPLPPLVLTQKKDG IEYRVAGDSQLSERFSNLHVDITYKELLSSAPISTKLSNIDTTFIKKDLDTPEGEDSY PSTLLSAYDFSSSGSNSAPLSANNIISCSNLIQGKDVDQLEEEAWRFGHLKDEITTLG ILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQY YGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLSYLH ERKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMTFTGTSFYMAPERIQGQPY SVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTFSPQLKDEPELDISW SKTFRSFIDYCLKKDARERPSPRQMLKHPWIVGQMKKKVNMERFVKKCWEKEKDGI" rep_origin 289485..289705 /note="ARS1614; Autonomously Replicating Sequence" /db_xref="SGD:S000118414" gene complement(289669..291051) /gene="UME1" /locus_tag="YPL139C" /gene_synonym="WTM3" mRNA complement(289669..291051) /gene="UME1" /locus_tag="YPL139C" /gene_synonym="WTM3" /product="Ume1p" CDS complement(289669..291051) /gene="UME1" /locus_tag="YPL139C" /gene_synonym="WTM3" /experiment="EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:9234739]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:25398614|PMID:9234739]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:25398614]" /experiment="EXISTENCE:direct assay:GO:0032221 Rpd3S complex [PMID:16286008|PMID:16286007]" /experiment="EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:16286008|PMID:16314178|PMID:16286007|PMID:19040720]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0016479 negative regulation of transcription by RNA polymerase I [PMID:19270272]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:20398213]" /experiment="EXISTENCE:mutant phenotype:GO:0040020 regulation of meiotic nuclear division [PMID:9234739]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20398213|PMID:17210643]" /note="Component of both the Rpd3S and Rpd3L histone deacetylase complexes; negative regulator of meiosis; required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p; UME1 has a paralog, WTM2, that arose from the whole genome duplication" /codon_start=1 /product="Ume1p" /protein_id="DAA11295.1" /db_xref="SGD:S000006060" /translation="MSTLDIAEDNKIKNEEFKIWKKSIPSLYQHISSLKPIFGSGVDE SPSTLRSIVFTNDSSCNKSKGVLSVPLLYSQGSEIFEVDCIVPLGLHYKKPESISEPL VQPDYTMESQKVEQTVLIPKWEFKGETIAKMIYVDNSEINVKVIALSTNGSLAWFREG VKSPVYTMMEPSTSLSSASSGNQNKPCVDFAISNDSKTLTVTKEKHLDNENATIKLID NSGKIGEVLRTIPVPGIKNIQEIKFLNNQIFATCSDDGIIRFWGNEIGKKPLWILNDS LDGKTTCFAASPFVDTLFMTGTSGGALKVWDIRAVIALGDADAELNINQGHNKVNELF KVHHFYSEQVSKIEFSSISPMEVVTIGGLGNVYHWNFEPVFAIYNEIHEDFQGIISDE LEAESMAFYHTEGCRREIGENNKVNTVAYHKYIEDLVATVDSDGLLTVYKPFTGKVLD GSREVGAAKS" gene complement(291366..292427) /gene="SPP1" /locus_tag="YPL138C" /gene_synonym="CPS40" /gene_synonym="SAF41" mRNA complement(291366..292427) /gene="SPP1" /locus_tag="YPL138C" /gene_synonym="CPS40" /gene_synonym="SAF41" /product="Spp1p" CDS complement(291366..292427) /gene="SPP1" /locus_tag="YPL138C" /gene_synonym="CPS40" /gene_synonym="SAF41" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:18845545]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0035064 methylated histone binding [PMID:17142463]" /experiment="EXISTENCE:direct assay:GO:0042800 histone H3K4 methyltransferase activity [PMID:11805083|PMID:11742990]" /experiment="EXISTENCE:mutant phenotype:GO:0003682 chromatin binding [PMID:23246437]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:11687631]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:11687631|PMID:11752412|PMID:11805083]" /experiment="EXISTENCE:mutant phenotype:GO:0042800 histone H3K4 methyltransferase activity [PMID:11752412]" /experiment="EXISTENCE:mutant phenotype:GO:1903341 regulation of meiotic DNA double-strand break formation [PMID:23246437]" /experiment="EXISTENCE:physical interaction:GO:0048188 Set1C/COMPASS complex [PMID:11687631|PMID:11742990|PMID:11752412]" /note="Subunit of COMPASS (Set1C); a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; promotes meiotic DSB formation by interacting with H3K4me3 and Rec107p, a protein required for Spo11p-catalyzed DSB formation located on chromosome axes; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein; relocalizes to cytosol in response to hypoxia" /codon_start=1 /product="Spp1p" /protein_id="DAA11296.1" /db_xref="SGD:S000006059" /translation="MSLPQWCPPHSTLKRNPTTGEDVYCICKRPDYGELMVGCDGCDD WFHFTCLHIPEQFKDLVFSFYCPYCQAGITGKNKDAIINGEGSLPKTLWKRKCRISDC YKPCLQDSKYCSEEHGREFVNDIWSRLKTDEDRAVVKKMVEQTGHIDKFKKFGQLDFI DNNIVVKTDDEKEIFDQIVVRDMTLKTLEDDLQEVQEISLPLFKKKLELLEVYLGWLD NVYTEMRKLDDDAASHVECGKEDSKGTKRKKKKNSSRSRARKNICGYCSTYERIPCSV EEFVRDFGSNEEATKIHEVCTKWKCNRHLDWVSTNQEQYLQQIDSLESMQERLQHLIQ ARKKQLNIQYYEEILRRGL" gene complement(292817..296647) /gene="GIP3" /locus_tag="YPL137C" mRNA complement(292817..296647) /gene="GIP3" /locus_tag="YPL137C" /product="protein phosphatase regulator GIP3" CDS complement(292817..296647) /gene="GIP3" /locus_tag="YPL137C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008157 protein phosphatase 1 binding [PMID:11841235]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:16537909]" /experiment="EXISTENCE:mutant phenotype:GO:0019888 protein phosphatase regulator activity [PMID:16537909]" /note="Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication" /codon_start=1 /product="protein phosphatase regulator GIP3" /protein_id="DAA11297.1" /db_xref="SGD:S000006058" /translation="MITNTEFDVPVDWLYKGKSRRKTNTKPSRPSTSPASSSSTSSSK NGDNSTSGNRSSNDKPRARSSSVSNAALCNTEKPDLKRNDGNTSASDTDNIPLLTPIN SGNRSDSADIDNPATVDAIDLIDNDDNGSSTQFVRKKRSTSISNAVVSSKPRLASSAI NATASSSVGKGKHPPISSPSNATLKRSNSTSGEKTKRSIFGSLFSKRSTSSSASTAKK PLPVVNTSTTENESGGIKAVATPDPRVKEISSPMRGVAPTASKPQTPILPSPALAVKD LSTVSLKRVSFAVDKFESDPPQQLPSRTPKKGNILIPDDMISEVPSISVGISSSNQSA KSTNSNIKGPLYTKKSKEYILALENQKLALREAAKHQQEAHFAANRIAFEVANFKTAS DAGGKLTEKSSEGTITKQREEVSPPNVEADRELENNKLAENLSKAGIDKPIHMHEHYF KEPDQDKYQDGHSIENNEVTLDVIYTRCCHLREILPIPSTLRQVKDKTAPLQILKFLN PKPTLIDILSFCDFITIAPIHTIVFDNVALNQDMFRIIISALVNSTVLDKLSLRNVRI DQDGWKLLCKFLLLNKSLNKLDISQTKIKSDLAESLYRHNMDWNLFTDVLSQRSHKPI EELLFNGIQFSKIPYSCFARLLTSFATQKNFPESGIRLGLAGATTSNISQDCLKFIFN WMSQYNVQGVDLAFNDLSTMIKPMVGKLSALSYDNLRYFILNSTNISTSYDLALLLKY LSKLPNLIFLDLSNLSQCFPDILPYMYKYLPRFPNLKRIHLDSNNLTLKELAVVCNIL IKCKSLSHVSMTNQNVENFYLMNGTDSPVQQTNTDGDLDSSSTLDVKGQFAKNSFSST LYAFARDSPNLIGLDFDYDLISEEIQSRIALCLMRNMKRTMDSTFQLDELDSQDDLLF DGSLVTMTAESVLEKLNLLSDKSTKVKKDTTKRYLLKKYIEKFHILHHNVQHTIDTMF EKRKSGELPLQEKENLVRLLLLEQNLCNILELFSHNPNLNDVLGSSRDDSKESVDSSE DSKLPALKHVESGYHVPEEKIQPENDVITARPHLMATDSGKTIDVFTGKPLVFKHTSS STSVGCKKQEEEEGELHKWGFFVQQQRSLYPENESTRQTPFASGDTPINTETAGKSTS SPSVSTSNNETATTSLFSPANPKILPKIPSGAVLRSAIMKAKGIDSIDDLIQNVNSNN IELENIYGESIQNSASTFTPGVDSDVSAPNTDKGSVETLPAVSTDDPNCEVKVTATYD KLLNNLSMERSIRL" gene 297553..298050 /gene="ISU1" /locus_tag="YPL135W" /gene_synonym="NUA1" mRNA 297553..298050 /gene="ISU1" /locus_tag="YPL135W" /gene_synonym="NUA1" /product="iron-binding protein ISU1" CDS 297553..298050 /gene="ISU1" /locus_tag="YPL135W" /gene_synonym="NUA1" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:12756240]" /experiment="EXISTENCE:direct assay:GO:0005506 iron ion binding [PMID:31532427]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:10468587|PMID:15143178]" /experiment="EXISTENCE:direct assay:GO:0008198 ferrous iron binding [PMID:12970193]" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:31532427]" /experiment="EXISTENCE:genetic interaction:GO:0002098 tRNA wobble uridine modification [PMID:17283054]" /experiment="EXISTENCE:genetic interaction:GO:0016226 iron-sulfur cluster assembly [PMID:12970193]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:10468587]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:31040179|PMID:15143178|PMID:10588895]" /note="Conserved protein of the mitochondrial matrix; performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); ISU1 has a paralog, ISU2, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant" /codon_start=1 /product="iron-binding protein ISU1" /protein_id="DAA11298.1" /db_xref="SGD:S000006056" /translation="MLPVITRFARPALMAIRPVNAMGVLRASSITKRLYHPKVIEHYT HPRNVGSLDKKLPNVGTGLVGAPACGDVMRLQIKVNDSTGVIEDVKFKTFGCGSAIAS SSYMTELVQGMTLDDAAKIKNTEIAKELSLPPVKLHCSMLAEDAIKAAIKDYKSKRNT PTMLS" gene complement(298571..299503) /gene="ODC1" /locus_tag="YPL134C" mRNA complement(298571..299503) /gene="ODC1" /locus_tag="YPL134C" /product="mitochondrial 2-oxodicarboxylate carrier" CDS complement(298571..299503) /gene="ODC1" /locus_tag="YPL134C" /experiment="EXISTENCE:direct assay:GO:0005310 dicarboxylic acid transmembrane transporter activity [PMID:11013234]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:9178508|PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11013234]" /experiment="EXISTENCE:direct assay:GO:0006839 mitochondrial transport [PMID:11013234]" /note="Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation; ODC1 has a paralog, ODC2, that arose from the whole genome duplication" /codon_start=1 /product="mitochondrial 2-oxodicarboxylate carrier" /protein_id="DAA11299.1" /db_xref="SGD:S000006055" /translation="MTSIDNRPLPFIYQFTAGAIAGVSELLVMYPLDVVKTRMQLQVT TKGHPAVVAAKAAVDHYTGVMDCLTKIVKKEGFSHLYKGITSPILMEAPKRAIKFSGN DTFQTFYKKIFPTPNGEMTQKIAIYSGASAGAVEAFVVAPFELVKIRLQDVNSQFKTP IEVVKNSVVKGGVLSLFNGLEATIWRHVLWNAGYFGIIFQIRKLLPAAKTSTEKTRND LIAGAIGGTVGCLLNTPFDVVKSRIQRSSGPLRKYNWSLPSVLLVYREEGFKALYKGF APKVMRLAPGGGLLLVVFTNVMDFFREVKYGKKQ" gene complement(299888..301228) /gene="RDS2" /locus_tag="YPL133C" mRNA complement(299888..301228) /gene="RDS2" /locus_tag="YPL133C" /product="gluconeogenesis transcription factor RDS2" CDS complement(299888..301228) /gene="RDS2" /locus_tag="YPL133C" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:17875938]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17875938]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:17875938]" /experiment="EXISTENCE:mutant phenotype:GO:0045722 positive regulation of gluconeogenesis [PMID:17875938]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11943786|PMID:17875938]" /experiment="EXISTENCE:mutant phenotype:GO:0071466 cellular response to xenobiotic stimulus [PMID:11943786]" /note="Transcription factor involved in regulating gluconeogenesis; also involved in the regulation of glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole" /codon_start=1 /product="gluconeogenesis transcription factor RDS2" /protein_id="DAA11300.1" /db_xref="SGD:S000006054" /translation="MSANSGVKRASKAFKTCLFCKRSHVVCDKQRPCSRCVKRDIAHL CREDDIAVPNEMPSQHESSPNDNNIQGKYANKAHTGIPSDYQNEPVNKSGSTYGEELS PKLDSSLVNDTTSLLLPQQPVFVSENVGSEFSSLNEFLSMLENPLLTQTSLSSSSASN VHLENGSQTTQSPLEYQNDNRRDEIGVARQENRSPTIMSGSSNSISKGDKQDQEKEES RILANANENSAPTPKEQFFLTAADPSTEMTPEHRLKLVINAKLEAGLLKPYNYAKGYA RLQDYMDKYMNQSSKQRILKPLSTIRPAFRTIARSLKDVDLVLVEESFERMLLSYDRV FTSMSMPACLCRRTGEIYRANKEFASLVDCTVDDLRDGKLAIYELMTEESAVNFWEKY GSIAFDKGQKAVLTSCSLRTKDGIRKRPCCFSFTIRRDRYNIPICIVGNFIPLS" gene 301716..302618 /gene="COX11" /locus_tag="YPL132W" /gene_synonym="LPI13" /gene_synonym="PSO7" mRNA 301716..302618 /gene="COX11" /locus_tag="YPL132W" /gene_synonym="LPI13" /gene_synonym="PSO7" /product="Cox11p" CDS 301716..302618 /gene="COX11" /locus_tag="YPL132W" /gene_synonym="LPI13" /gene_synonym="PSO7" /experiment="EXISTENCE:direct assay:GO:0005507 copper ion binding [PMID:12063264]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:2167832]" /experiment="EXISTENCE:direct assay:GO:0005740 mitochondrial envelope [PMID:2167832]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:10501934|PMID:15776235]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:direct assay:GO:0005761 mitochondrial ribosome [PMID:15776235]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:10617659]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:34919594]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:2167832]" /note="Protein required for delivery of copper to Cox1p; mitochondrial inner membrane protein; involved in oxidative stress response; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p" /codon_start=1 /product="Cox11p" /protein_id="DAA11301.1" /db_xref="SGD:S000006053" /translation="MIRICPIVRSKVPLLGTFLRSDSWLAPHALALRRAICKNVALRS YSVNSEQPKHTFDISKLTRNEIQQLRELKRARERKFKDRTVAFYFSSVAVLFLGLAYA AVPLYRAICARTGFGGIPITDRRKFTDDKLIPVDTEKRIRISFTSEVSQILPWKFVPQ QREVYVLPGETALAFYKAKNYSDKDIIGMATYSIAPGEAAQYFNKIQCFCFEEQKLAA GEEIDMPVFFFIDPDFASDPAMRNIDDIILHYTFFRAHYGDGTAVSDSKKEPEMNADE KAASLANAAILSPEVIDTRKDNSN" gene 303121..304014 /gene="RPL5" /locus_tag="YPL131W" /gene_synonym="LPI14" /gene_synonym="RPL1" mRNA 303121..304014 /gene="RPL5" /locus_tag="YPL131W" /gene_synonym="LPI14" /gene_synonym="RPL1" /product="ribosomal 60S subunit protein L5" CDS 303121..304014 /gene="RPL5" /locus_tag="YPL131W" /gene_synonym="LPI14" /gene_synonym="RPL1" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0008097 5S rRNA binding [PMID:8764831]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:8474444]" /note="Ribosomal 60S subunit protein L5; nascent Rpl5p is bound by specific chaperone Syo1p during translation; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly" /codon_start=1 /product="ribosomal 60S subunit protein L5" /protein_id="DAA11302.1" /db_xref="SGD:S000006052" /translation="MAFQKDAKSSAYSSRFQTPFRRRREGKTDYYQRKRLVTQHKAKY NTPKYRLVVRFTNKDIICQIISSTITGDVVLAAAYSHELPRYGITHGLTNWAAAYATG LLIARRTLQKLGLDETYKGVEEVEGEYELTEAVEDGPRPFKVFLDIGLQRTTTGARVF GALKGASDGGLYVPHSENRFPGWDFETEEIDPELLRSYIFGGHVSQYMEELADDDEER FSELFKGYLADDIDADSLEDIYTSAHEAIRADPAFKPTEKKFTKEQYAAESKKYRQTK LSKEERAARVAAKIAALAGQQ" gene 304387..305058 /gene="SPO19" /locus_tag="YPL130W" mRNA 304387..305058 /gene="SPO19" /locus_tag="YPL130W" /product="Spo19p" CDS 304387..305058 /gene="SPO19" /locus_tag="YPL130W" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:18756268]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:genetic interaction:GO:0051321 meiotic cell cycle [PMID:17179081]" /experiment="EXISTENCE:genetic interaction:GO:0070583 spore membrane bending pathway [PMID:18756268]" /experiment="EXISTENCE:mutant phenotype:GO:0070583 spore membrane bending pathway [PMID:18756268]" /note="Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation; SPO19 has a paralog, YOR214C, that arose from the whole genome duplication" /codon_start=1 /product="Spo19p" /protein_id="DAA11303.1" /db_xref="SGD:S000006051" /translation="MKKQILIVAAQSILCSTVFGERSNVGLSTEELGGDSILYFNEDP IVIEIDKKAIDKKTLEQLASTRDVVLTDLPDTLEFIDFNEYAKMKSKSDMLLEYINEY EFDDFERSSEGGLEEEEEEDLIYDFNAQAEDLGKLGSNIYEVVEEKNIVNTYDGNLIN ASTTESTTTIRPFVTSHSYVASSTPYSNISSLNEDYDNASNFLTPTTVALAVLLTILL FIQAY" gene 305298..306137 /gene="TAF14" /locus_tag="YPL129W" /gene_synonym="ANC1" /gene_synonym="SWP29" /gene_synonym="TAF30" /gene_synonym="TFG3" mRNA join(305298..305306,305412..306137) /gene="TAF14" /locus_tag="YPL129W" /gene_synonym="ANC1" /gene_synonym="SWP29" /gene_synonym="TAF30" /gene_synonym="TFG3" /product="TATA-binding protein-associated factor TAF14" CDS join(305298..305306,305412..306137) /gene="TAF14" /locus_tag="YPL129W" /gene_synonym="ANC1" /gene_synonym="SWP29" /gene_synonym="TAF30" /gene_synonym="TFG3" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:35970389]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:10788514|PMID:15448131]" /experiment="EXISTENCE:direct assay:GO:0005674 transcription factor TFIIF complex [PMID:7995524|PMID:12242279|PMID:15896708]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12887900]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:12138208|PMID:15448131]" /experiment="EXISTENCE:direct assay:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:35970389|PMID:1331084]" /experiment="EXISTENCE:direct assay:GO:0016251 RNA polymerase II general transcription initiation factor activity [PMID:14749386]" /experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:18644858]" /experiment="EXISTENCE:direct assay:GO:0016592 mediator complex [PMID:8187178]" /experiment="EXISTENCE:direct assay:GO:0031011 Ino80 complex [PMID:12887900]" /experiment="EXISTENCE:direct assay:GO:0033100 NuA3 histone acetyltransferase complex [PMID:10817755|PMID:17157260]" /experiment="EXISTENCE:direct assay:GO:1990467 NuA3a histone acetyltransferase complex [PMID:25104842]" /experiment="EXISTENCE:direct assay:GO:1990468 NuA3b histone acetyltransferase complex [PMID:25104842]" /experiment="EXISTENCE:physical interaction:GO:0005674 transcription factor TFIIF complex [PMID:15896708]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]" /note="Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; serves as an additional DNA binding domain for the complex; contains a YEATS domain" /codon_start=1 /product="TATA-binding protein-associated factor TAF14" /protein_id="DAA11304.1" /db_xref="SGD:S000006050" /translation="MVATVKRTIRIKTQQHILPEVPPVENFPVRQWSIEIVLLDDEGK EIPATIFDKVIYHLHPTFANPNRTFTDPPFRIEEQGWGGFPLDISVFLLEKAGERKIP HDLNFLQESYEVEHVIQIPLNKPLLTEELAKSGSTEETTANTGTIGKRRTTTNTTAEP KAKRAKTGSASTVKGSVDLEKLAFGLTKLNEDDLVGVVQMVTDNKTPEMNVTNNVEEG EFIIDLYSLPEGLLKSLWDYVKKNTE" gene complement(306533..308221) /gene="TBF1" /locus_tag="YPL128C" /gene_synonym="LPI16" mRNA complement(306533..308221) /gene="TBF1" /locus_tag="YPL128C" /gene_synonym="LPI16" /product="Tbf1p" CDS complement(306533..308221) /gene="TBF1" /locus_tag="YPL128C" /gene_synonym="LPI16" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:20513435]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:20513435]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:20513435]" /experiment="EXISTENCE:direct assay:GO:0001015 snoRNA transcription by RNA polymerase II [PMID:20513435]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0010833 telomere maintenance via telomere lengthening [PMID:17917674]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:20513435]" /experiment="EXISTENCE:direct assay:GO:0043035 chromatin insulator sequence binding [PMID:11258704]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:23222485]" /experiment="EXISTENCE:genetic interaction:GO:0032211 negative regulation of telomere maintenance via telomerase [PMID:16467854]" /experiment="EXISTENCE:mutant phenotype:GO:0001015 snoRNA transcription by RNA polymerase II [PMID:20513435]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:23222485]" /note="Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation; involved in nucleosome displacement during double-strand break repair" /codon_start=1 /product="Tbf1p" /protein_id="DAA11305.1" /db_xref="SGD:S000006049" /translation="MDSQVPNNNESLNRFNDIIQSLPARTRLTICSLCLLDNISTQLL RFLILNANSPNIIAVLTDQTAFLSSGETEIFQTLVKLFKQIRMIYHTRSPLLSVHDVA PGLWFPNSPPPLILRGHEAFIITAIRKANLLTFLLTSLNCLNYGFELLQSIFLDIFCP NTNTVGNNSLEQSGKFLKSQAILYLDLKTQAYIAGLKEFQDETNEISLEKKQELLDLI FPSNLADILVQRRTGDSGDITLLTPSEKDFVERCDRRRENLKIVQDFNSLTQSYEWAQ FIRELLDYCNKNMGLIIWGRKGRGKSPLYDFDVNEFDPQVLFSTGTRTVEFMDDQNQP SSASAFLSTARPNHYSTHTPTTDVSSKNPAITQSIVDAAVAASMSNSSSGPHSSHNNS SNSNNNGSIGLRKPKAKRTWSKEEEEALVEGLKEVGPSWSKILDLYGPGGKITENLKN RTQVQLKDKARNWKLQYLKSGKPLPDYLIKVTGNLEKIYKAKKKFSQSPNSSTIMEQN LSQHPSSAASATEDTQTHQEDSHGQNSDNMPSNGLFGNSTSDNTGFDPHLEDGM" gene complement(308828..309604) /gene="HHO1" /locus_tag="YPL127C" mRNA complement(308828..309604) /gene="HHO1" /locus_tag="YPL127C" /product="histone H1" CDS complement(308828..309604) /gene="HHO1" /locus_tag="YPL127C" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:22586276]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:11574687]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:9046096]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:11574687]" /experiment="EXISTENCE:mutant phenotype:GO:0030261 chromosome condensation [PMID:22586276]" /experiment="EXISTENCE:mutant phenotype:GO:0043934 sporulation [PMID:22586276]" /experiment="EXISTENCE:mutant phenotype:GO:0045910 negative regulation of DNA recombination [PMID:12820979]" /experiment="EXISTENCE:mutant phenotype:GO:2000779 regulation of double-strand break repair [PMID:31821952]" /note="Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination" /codon_start=1 /product="histone H1" /protein_id="DAA11306.1" /db_xref="SGD:S000006048" /translation="MAPKKSTTKTTSKGKKPATSKGKEKSTSKAAIKKTTAKKEEASS KSYRELIIEGLTALKERKGSSRPALKKFIKENYPIVGSASNFDLYFNNAIKKGVEAGD FEQPKGPAGAVKLAKKKSPEVKKEKEVSPKPKQAATSVSATASKAKAASTKLAPKKVV KKKSPTVTAKKASSPSSLTYKEMILKSMPQLNDGKGSSRIVLKKYVKDTFSSKLKTSS NFDYLFNSAIKKCVENGELVQPKGPSGIIKLNKKKVKLST" gene 310210..312900 /gene="NAN1" /locus_tag="YPL126W" /gene_synonym="UTP17" mRNA 310210..312900 /gene="NAN1" /locus_tag="YPL126W" /gene_synonym="UTP17" /product="Nan1p" CDS 310210..312900 /gene="NAN1" /locus_tag="YPL126W" /gene_synonym="UTP17" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:15489292]" /experiment="EXISTENCE:direct assay:GO:0034455 t-UTP complex [PMID:17515605]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:15489292]" /note="U3 snoRNP protein; component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA; localizes to nucleolus and peroxisomes" /codon_start=1 /product="Nan1p" /protein_id="DAA11307.1" /db_xref="SGD:S000006047" /translation="MTQSLGIEQYKLSVVSGGKPALNNLSSVTGNKNIARLSQDQRNY IIPFNNQIKVYSVETRQCVKTLKFANNSLLSGIFLQEEENNESIVKILLGDITVPQQE DAHLITVFTNNGHVIVLNYKGKLVESPKHFKISLADEKLANVFHSEGNYRILTTFKDP SQKAHNSLQSYRLYALTFDDAKKQFEVAHQAEWHNVILSNISSNGKLLAHMCKDVSTK DHEHKSISVVSLFDDSVNLSFPLGSILSSQTQSLSYNTRYVSSMAIDNMGQQLAVGFA SGVISIVSLADLQIRLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLETNSQQFL PRLNGIIIDCQVLGPQGNYYSLILQMTENNSNSDYQFLLLNASDLTSKLSINGPLPVF NSTIKHIQQPISAMNTKNSNSITSLNHSKKKQSRKLIKSRRQDFTTNVEINPINKNLY FPHISAVQIFDFYKNEQVNYQYLTSGVNNSMGKVRFELNLQDPIITDLKFTKDGQWMI TYEIEYPPNDLLSSKDLTHILKFWTKNDNETNWNLKTKVINPHGISVPITKILPSPRS VNNSQGCLTADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSLAWSQDGSLIFH GFDDKLQILDFDTFKKFESLENTKTVSEFTLDSEIQTVKLINDTNLIVATRTTLNAIN LLRGQVINSFDLYPFVNGVYKNGHMDRLITCDERTGNIALVINQQLTDLDGVPTINYK SRIIIFDSDLSTKLGNFTHHEYISWIGWNYDTDFIFLDIESTLGVVGTTVNTQLSDEV NNEGILDGLVSNTITTSASNSDIFAEQLHKLSSRGKKSDTRDKNTNDNDEDEEDIALE FINGEKKDKLVNMNSFTSMFDNIQNVQMDTFFDRVMKVLT" gene 313388..316486 /gene="KAP120" /locus_tag="YPL125W" /gene_synonym="LPH2" mRNA 313388..316486 /gene="KAP120" /locus_tag="YPL125W" /gene_synonym="LPH2" /product="karyopherin KAP120" CDS 313388..316486 /gene="KAP120" /locus_tag="YPL125W" /gene_synonym="LPH2" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16581791|PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0006606 protein import into nucleus [PMID:20219973]" /experiment="EXISTENCE:direct assay:GO:0008139 nuclear localization sequence binding [PMID:20219973]" /experiment="EXISTENCE:direct assay:GO:0061608 nuclear import signal receptor activity [PMID:20219973]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:20219973|PMID:16581791]" /experiment="EXISTENCE:mutant phenotype:GO:0061608 nuclear import signal receptor activity [PMID:20219973]" /experiment="EXISTENCE:physical interaction:GO:0006606 protein import into nucleus [PMID:16581791]" /note="Karyopherin responsible for the nuclear import of Rpf1p; Rpf1p is a ribosome maturation factor" /codon_start=1 /product="karyopherin KAP120" /protein_id="DAA11308.1" /db_xref="SGD:S000006046" /translation="MASSLNELNLVQVLEQASNPQHIRSDVQKLAEQQLRQWETQAGF HYLLQSIYLNLSNSLQIRWLAVIQFKNGVDKYWRSTRINAIPKDEKASIRGRLFEMID EQNNQLCIQNAQASARIARLDFPVEWPTLFEDLENLLNDEIIRKDSVKIYNILMHINQ IVKVLGTARIGRCRPAMQSKVPLILPLIVRIYLQSFEEWTTSSNLNYEDLSSLQVSYL ALKVLRRIICEGYDRPQTDQSVCDFIKLSVSHFEMLISNHENFKKFDIYEKFIKCLGK LYFNLVTGSPANFILLPCSTQILITYTRLIFDKAPKVYRENSDVTGDFWEQTAIRGLL ILKRVINFIHKKGAITLKARSDKLTIDASINKINTEFLNENLITRLVDTLMEWYLRLR PTELENWFMDPEEWINEQMATSYEYQIRPCAENVFQDLMNTFSELLVPYLLKKIENDA SKLSNSLDDFLRKDAIYASFQLSASAVSEMVDFDRLLIQVFLPEATNTNISGDELRII RRRVALIINEWSTVKCSEESKSLCYKLFTNFLTDEDDKVVLLTTVQTVRTMVDDWNFN KDTFQPFLTENVHLLLRKILPSVSLTETRLYVLNTLSDIIIQTKPLISRDLLVEILQI IPNLWEIATNNASEAILANALLRLLRNLVSSLGSQSHLTWDIAIPVVALACDPSSMQY QLLSEDGYELWGMLLQNFSSHDQEFDDKFVELVPFLKYGIETHTEILPTLLEIIKSYA LILNPVDFFSNNTFQDIFKQMSKYLLKLREDSFQLVLEIWEILILSNESDYENLLLQK FYETGVLSALFDAIFLEEAPSSYLCSQIIQIIARISYVNPDALMTFLATYHDNLPTSN ENARMPESIRKIVSKDQTYDSVVNKLLTGWIVCFRDIFDPKFKKVHILGISSLLRTGL VPILTEFSSIASLWIEMLEEINETNRGDCEKYHLNDIVTEQSIAFHPLTAEQLRYHQL CKNNDPVHNISLKDFISQSMEYLESHLGVERYQEFLKTINPSLLENLQMFLSIQPQEA RP" gene 316755..317516 /gene="SPC29" /locus_tag="YPL124W" /gene_synonym="LPH3" /gene_synonym="NIP29" mRNA 316755..317516 /gene="SPC29" /locus_tag="YPL124W" /gene_synonym="LPH3" /gene_synonym="NIP29" /product="Spc29p" CDS 316755..317516 /gene="SPC29" /locus_tag="YPL124W" /gene_synonym="LPH3" /gene_synonym="NIP29" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0061493 central plaque of mitotic spindle pole body [PMID:10339566]" /experiment="EXISTENCE:mutant phenotype:GO:1903087 mitotic spindle pole body duplication [PMID:10330408|PMID:10339566]" /note="Inner plaque spindle pole body (SPB) component; links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication" /codon_start=1 /product="Spc29p" /protein_id="DAA11309.1" /db_xref="SGD:S000006045" /translation="MDYSNFGNSASKKFQDDTLNRVRKEHEEALKKLREENFSSNTSE LGNKKHYRAQERMSSPLHRLSPTGKSDDRKVKSPLDDKLRRQLREGNTRLPPPPFSSY GMPPTNRSNLDRIRRRTSSPVRTDKFASQNVIDDQRLEIKYLERIVYDQGTVIDNLTS RITRLESFILNSISDRGDKNFASLEHSRSFSGFPTNKTYGLQMGGLYENDMPYRRSSD NINKEGAREDRSSQIHIENESTEDILKILSSSFHN" gene complement(317641..318945) /gene="RNY1" /locus_tag="YPL123C" mRNA complement(317641..318945) /gene="RNY1" /locus_tag="YPL123C" /product="ribonuclease T2" CDS complement(317641..318945) /gene="RNY1" /locus_tag="YPL123C" /EC_number="4.6.1.19" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:24102742]" /experiment="EXISTENCE:direct assay:GO:0004521 RNA endonuclease activity [PMID:11158587]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:11158587]" /experiment="EXISTENCE:direct assay:GO:0005773 vacuole [PMID:19332891]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:19332891|PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006915 apoptotic process [PMID:19332891]" /experiment="EXISTENCE:mutant phenotype:GO:0000902 cell morphogenesis [PMID:11158587]" /experiment="EXISTENCE:mutant phenotype:GO:0004521 RNA endonuclease activity [PMID:19332891]" /experiment="EXISTENCE:mutant phenotype:GO:0006401 RNA catabolic process [PMID:19332891]" /experiment="EXISTENCE:mutant phenotype:GO:0006402 mRNA catabolic process [PMID:33875662]" /note="Vacuolar RNase of the T(2) family; relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; required for tRNA-specific translational pausing during oxidative stress; promotes apoptosis under stress conditions and this function is independent of Rny1p catalytic activity" /codon_start=1 /product="ribonuclease T2" /protein_id="DAA11310.1" /db_xref="SGD:S000006044" /translation="MLLKNLHSLLQLPIFSNGADKGIEPNCPINIPLSCSNKTDIDNS CCFEYPGGIFLQTQFWNYFPSKNDLNETELVKELGPLDSFTIHGLWPDNCHGGYQQFC NRSLQIDDVYYLLHDKKFNNNDTSLQISGEKLLEYLDLYWKSNNGNHESLWIHEFNKH GTCISTIRPECYTEWGANSVDRKRAVYDYFRITYNLFKKLDTFSTLEKNNIVPSVDNS YSLEQIEAALSKEFEGKKVFIGCDRHNSLNEVWYYNHLKGSLLSEMFVPMDSLAIRTN CKKDGIKFFPKGYVPTFRRRPNKGARYRGVVRLSNINNGDQMQGFLIKNGHWMSQGTP ANYELIKSPYGNYYLRTNQGFCDIISSSSNELVCKFRNIKDAGQFDFDPTKGGDGYIG YSGNYNWGGDTYPRRRNQSPIFSVDDEQNSKKYKFKLKFIKN" gene complement(319226..320767) /gene="TFB2" /locus_tag="YPL122C" mRNA complement(319226..320767) /gene="TFB2" /locus_tag="YPL122C" /product="TFIIH/NER complex subunit TFB2" CDS complement(319226..320767) /gene="TFB2" /locus_tag="YPL122C" /experiment="EXISTENCE:direct assay:GO:0000439 transcription factor TFIIH core complex [PMID:14500720|PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:19897425]" /experiment="EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:19818408|PMID:27381459]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19818408]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:9235928]" /experiment="EXISTENCE:physical interaction:GO:0000112 nucleotide-excision repair factor 3 complex [PMID:10681587]" /note="Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH" /codon_start=1 /product="TFIIH/NER complex subunit TFB2" /protein_id="DAA11311.1" /db_xref="SGD:S000006043" /translation="MSDYSLKHSVTQYLEEIPQQVQNRLYTSPATCLAIYRILPPLAK FFIMAMVFNENEVPLLDLDKWVNSNGKLQFQNAIKSMKSLHLLIPNKSSGTLMINLNP TFKISLRNALTGGEVQNSFGVVVEENVVSLDLLDEYSANKWETILHFMVGTPLAKIPS EKVLNLLKHSKLMEEVNSTGEFKITNEGFQFLLQEINSQLWTLLLQYLKMIETSKMDL VDVLHFIFMLGALEVGKAYKIDALSETQRIMLQDMRDYGLVFQKHSNDSIFYPTKLAL MLTSDTKTIRSASNAMDSVLRQNREEPSVNEDGANGKSTTDITTSDDLNKAGLKNQDI PDGSLIVETNFKIYSYSNSPLQIAVLSLFVHLKARFVNMVLGQITRESIRRALTNGIT ADQIIAYLETHAHPQMRRLAEEKLEKKLELDPNCKEPLQVLPPTVVDQIRLWQLELDR VITYEGSLYSDFETSQEYNLLSKYAQDIGVLLWKDDKKKKFFISKEGNSQVLDFAKRK LKKKQ" gene complement(320962..321630) /gene="MEI5" /locus_tag="YPL121C" /gene_synonym="LPH6" mRNA complement(320962..321630) /gene="MEI5" /locus_tag="YPL121C" /gene_synonym="LPH6" /product="Mei5p" CDS complement(320962..321630) /gene="MEI5" /locus_tag="YPL121C" /gene_synonym="LPH6" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:15620352|PMID:15579681]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24390141]" /experiment="EXISTENCE:mutant phenotype:GO:0000707 meiotic DNA recombinase assembly [PMID:15620352|PMID:15579681]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:15579681|PMID:15620352]" /note="Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p" /codon_start=1 /product="Mei5p" /protein_id="DAA11312.1" /db_xref="SGD:S000006042" /translation="MHNQEEWLDKDKTLVNEEENTCINHSYTKKDTNNYRVGKSGIKD LKKPTNQKEIAIKNRELTKQLTLLRQENNHLQQACKILSENKIIENRKSIEKWRTICE MELSFILNSTLIKINRMGGYKDFLEKEMEAKKRRLEYQIDNGMEDQICEIKESDDFRQ LSEVEKQEWESQMNEQLKELEKKKIAELEKLNKVLHDSEGKDFGMAELCTRLKLDYSL IFPQ" gene 322071..323744 /gene="VPS30" /locus_tag="YPL120W" /gene_synonym="APG6" /gene_synonym="ATG6" /gene_synonym="VPT30" mRNA 322071..323744 /gene="VPS30" /locus_tag="YPL120W" /gene_synonym="APG6" /gene_synonym="ATG6" /gene_synonym="VPT30" /product="beclin 1" CDS 322071..323744 /gene="VPS30" /locus_tag="YPL120W" /gene_synonym="APG6" /gene_synonym="ATG6" /gene_synonym="VPT30" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9105038]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I [PMID:11157979]" /experiment="EXISTENCE:direct assay:GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II [PMID:11157979]" /experiment="EXISTENCE:direct assay:GO:0120095 vacuole-isolation membrane contact site [PMID:23549786]" /experiment="EXISTENCE:genetic interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:12244127]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:21121900]" /experiment="EXISTENCE:mutant phenotype:GO:0006661 phosphatidylinositol biosynthetic process [PMID:12244127]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:22437838]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:11157979|PMID:32788210]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:9712845|PMID:9105038]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:12244127]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:11157979]" /experiment="EXISTENCE:mutant phenotype:GO:0051365 cellular response to potassium ion starvation [PMID:32788210]" /note="Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy, Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has novel globular fold essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of higher eukaryote gene Beclin 1; human BECN1 can complement yeast null mutant" /codon_start=1 /product="beclin 1" /protein_id="DAA11313.1" /db_xref="SGD:S000006041" /translation="MKCQTCHLPLQLDPSLEGLSLTQRNLLLSNNSIITATNENVISN KGIEAADNCGPQIPKERLRRLGEIQNIKDLNLKDDKLITDSFVFLNHDDDDNANITSN SREDQRYGNANGNDNKKANSDTSDGTSTFRDHDEEEQEATDEDENQQIQLNSKTLSTQ VNAMTNVFNILSSQTNIDFPICQDCCNILINRLKSEYDDAIKERDTYAQFLSKLESQN KEISESNKEKQYSHNLSEKENLKKEEERLLDQLLRLEMTDDDLDGELVRLQEKKVQLE NEKLQKLSDQNLMDLNNIQFNKNLQSLKLQYELSLNQLDKLRKINIFNATFKISHSGP FATINGLRLGSIPESVVPWKEINAALGQLILLLATINKNLKINLVDYELQPMGSFSKI KKRMVNSVEYNNSTTNAPGDWLILPVYYDENFNLGRIFRKETKFDKSLETTLEIISEI TRQLSTIASSYSSQTLTTSQDESSMNNANDVENSTSILELPYIMNKDKINGLSVKLHG SSPNLEWTTAMKFLLTNVKWLLAFSSNLLSKSITLSPTVNYNDKTISGN" gene complement(324024..324287) /locus_tag="YPL119C-A" mRNA complement(324024..324287) /locus_tag="YPL119C-A" /product="hypothetical protein" CDS complement(324024..324287) /locus_tag="YPL119C-A" /note="hypothetical protein; identified by expression profiling and mass spectrometry" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11314.1" /db_xref="SGD:S000028859" /translation="MHPLVDELTLSRYLTHGTSVLSSSLYSVAFFLFFFPNFLFFCSC PNHKWVSLPFIGMDILEALCFYREGKIRNIFEIGGLLLQSFYN" gene complement(324411..326264) /gene="DBP1" /locus_tag="YPL119C" /gene_synonym="LPH8" mRNA complement(324411..326264) /gene="DBP1" /locus_tag="YPL119C" /gene_synonym="LPH8" /product="putative DEAD-box ATP-dependent RNA helicase DBP1" CDS complement(324411..326264) /gene="DBP1" /locus_tag="YPL119C" /gene_synonym="LPH8" /EC_number="3.6.4.13" /experiment="EXISTENCE:direct assay:GO:0003727 single-stranded RNA binding [PMID:31299079]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:31299079]" /experiment="EXISTENCE:direct assay:GO:0033677 DNA/RNA helicase activity [PMID:21884706]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:30855040]" /experiment="EXISTENCE:direct assay:GO:1901195 positive regulation of formation of translation preinitiation complex [PMID:31299079]" /experiment="EXISTENCE:genetic interaction:GO:0006413 translational initiation [PMID:31299079]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:14763975]" /note="ATP-dependent RNA helicase of the DEAD-box protein family; accelerates eIF4F-dependent assembly of 48S translation preinitiation complex (PIC), stimulating recruitment of mRNAs with long, structured 5'-UTRs; cooperates with DEAD-box RNA helicase and paralog Ded1p, stimulating PIC attachment and highly processive scanning by the 40S ribosomal subunit; binds G-quadruplex (G4) DNA; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="putative DEAD-box ATP-dependent RNA helicase DBP1" /protein_id="DAA11315.1" /db_xref="SGD:S000006040" /translation="MADLPQKVSNLSINNKENGGGGGKSSYVPPHLRSRGKPSFERST PKQEDKVTGGDFFRRAGRQTGNNGGFFGFSKERNGGTSANYNRGGSSNYKSSGNRWVN GKHIPGPKNAKLEAELFGVHDDPDYHSSGIKFDNYDNIPVDASGKDVPEPILDFSSPP LDELLMENIKLASFTKPTPVQKYSIPIVTKGRDLMACAQTGSGKTGGFLFPLFTELFR SGPSPVPEKAQSFYSRKGYPSALVLAPTRELATQIFEEARKFTYRSWVRPCVVYGGAP IGNQMREVDRGCDLLVATPGRLNDLLERGKVSLANIKYLVLDEADRMLDMGFEPQIRH IVEECDMPSVENRQTLMFSATFPVDIQHLARDFLDNYIFLSVGRVGSTSENITQRILY VDDMDKKSALLDLLSAEHKGLTLIFVETKRMADQLTDFLIMQNFKATAIHGDRTQAER ERALSAFKANVADILVATAVAARGLDIPNVTHVINYDLPSDIDDYVHRIGRTGRAGNT GVATSFFNSNNQNIVKGLMEILNEANQEVPTFLSDLSRQNSRGGRTRGGGGFFNSRNN GSRDYRKHGGNGSFGSTRPRNTGTSNWGSIGGGFRNDNEKNGYGNSNASWW" gene 326628..327662 /gene="MRP51" /locus_tag="YPL118W" /gene_synonym="bS1m" mRNA 326628..327662 /gene="MRP51" /locus_tag="YPL118W" /gene_synonym="bS1m" /product="mitochondrial 37S ribosomal protein MRP51" CDS 326628..327662 /gene="MRP51" /locus_tag="YPL118W" /gene_synonym="bS1m" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9528754|PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:9528754|PMID:11278769]" /experiment="EXISTENCE:genetic interaction:GO:0070124 mitochondrial translational initiation [PMID:9528754]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:9528754]" /note="Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences" /codon_start=1 /product="mitochondrial 37S ribosomal protein bS1m MRP51" /protein_id="DAA11316.1" /db_xref="SGD:S000006039" /translation="MTLAELLGRSRIAQVANNHKPLTYTGKKFHPTHQIIETKPSTLY RQEWGLKSAIPSKIKSRYLVYNDLDTLERITTFEPRGGTQWNRLRFQEMGVPIVSNIG RQNPFFKYISRPEDESHAKLSLFKEMKGDTDISPAAMKKRLKKITALIRSFQDEFKEW LVENHPDELKLNSNKLEDYVVKFLNKKLETKTNKKFNTEIIGTGGLSYSLPGKLKNSP NGVIQRTVVPGRILNVVKENNDNKWLAAIGGFVADVVFFQSPPSSFNSMGDFIRMKTF LFEILEASMEKNGSVSMHARLLEPQNDKTREFFNKRPIYKPLTSRRARRPSVGNIQEA NNLLNIIKGN" gene complement(327864..328730) /gene="IDI1" /locus_tag="YPL117C" /gene_synonym="BOT2" /gene_synonym="LPH10" mRNA complement(327864..328730) /gene="IDI1" /locus_tag="YPL117C" /gene_synonym="BOT2" /gene_synonym="LPH10" /product="isopentenyl-diphosphate delta-isomerase IDI1" CDS complement(327864..328730) /gene="IDI1" /locus_tag="YPL117C" /gene_synonym="BOT2" /gene_synonym="LPH10" /EC_number="5.3.3.2" /experiment="EXISTENCE:direct assay:GO:0004452 isopentenyl-diphosphate delta-isomerase activity [PMID:2681212]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:2681212]" /experiment="EXISTENCE:direct assay:GO:0045337 farnesyl diphosphate biosynthetic process [PMID:7858969]" /note="Isopentenyl diphosphate:dimethylallyl diphosphate isomerase; catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability; isopentenyl diphosphate:dimethylallyl diphosphate isomerase is also known as IPP isomerase" /codon_start=1 /product="isopentenyl-diphosphate delta-isomerase IDI1" /protein_id="DAA11317.1" /db_xref="SGD:S000006038" /translation="MTADNNSMPHGAVSSYAKLVQNQTPEDILEEFPEIIPLQQRPNT RSSETSNDESGETCFSGHDEEQIKLMNENCIVLDWDDNAIGAGTKKVCHLMENIEKGL LHRAFSVFIFNEQGELLLQQRATEKITFPDLWTNTCCSHPLCIDDELGLKGKLDDKIK GAITAAVRKLDHELGIPEDETKTRGKFHFLNRIHYMAPSNEPWGEHEIDYILFYKINA KENLTVNPNVNEVRDFKWVSPNDLKTMFADPSYKFTPWFKIICENYLFNWWEQLDDLS EVENDRQIHRML" gene 329606..331699 /gene="HOS3" /locus_tag="YPL116W" mRNA 329606..331699 /gene="HOS3" /locus_tag="YPL116W" /product="histone deacetylase" CDS 329606..331699 /gene="HOS3" /locus_tag="YPL116W" /EC_number="3.5.1.98" /experiment="EXISTENCE:direct assay:GO:0004407 histone deacetylase activity [PMID:10535926]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:19823668]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19823668]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17706600]" /experiment="EXISTENCE:physical interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:19823668]" /experiment="EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19823668]" /note="Trichostatin A-insensitive homodimeric histone deacetylase (HDAC); specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats" /codon_start=1 /product="histone deacetylase" /protein_id="DAA11318.1" /db_xref="SGD:S000006037" /translation="MSSKHSDPLERFYKQFQAFVQNNPNVISAARAAAQIPESAKAVV VLSPYSLQHVFPREWVTKSYRKTIVERPERLLASSMGISAAITMYPSLFTLKSSHQRK GSLMAPHVLKVHGSSWPAELIELCQMADAKLLKGEIEVPDTWNSGDIYLSSKTIKALQ GTIGAIETGVDSIFKGPSAEHISNRAFVAIRPPGHHCHYGTPSGFCLLNNAHVAIEYA YDTYNVTHVVVLDFDLHHGDGTQDICWKRAGFKPEEEPEDSSYDDFGKKFAEFPKVGY FSMHDINSFPTESGFATKENIKNASTCIMNSHDLNIWNIHLSKWTTEEEFNVLYRTKY RTLFAKADEFFRSAKLEMNQQGRPFKGLVVISAGFDASEFEQTSMQRHSVNVPTSFYT TFTKDALKLAQMHCHGKVLSLMEGGYSDKAICSGVFAHLIGLQNQDWVKEWGSEQVVK EIVRGCKPAWKPYKTKRAKDVIRIWAEEVIRLGRAMIPEFDDIIFKDAVNSAPSNSLL KATVEPASTSTIAQRIIRSHRSNASPEKELHENKPRSTEKQEQREIRSDTKVKQLSSN NRAAETQIPFLQQEFSSEDEDEEYVYDEELNKTFNRTVEDITIDDISRHLETLEIEKK GDEDSDHELKEKNWKNSHQRRLQGNGMYKIPSNTKPHRIRQPQNANTPTYDDSDISMI SHVSRKHTTRSGGRW" rep_origin 331699..332100 /note="ARS1617; Replication origin; identified in multiple array studies, confirmed by plasmid-based recombinational ARS assay" /db_xref="SGD:S000130199" gene complement(332100..335486) /gene="BEM3" /locus_tag="YPL115C" mRNA complement(332100..335486) /gene="BEM3" /locus_tag="YPL115C" /product="GTPase-activating protein BEM3" CDS complement(332100..335486) /gene="BEM3" /locus_tag="YPL115C" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:17914457]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:12455995|PMID:8300560|PMID:8227021|PMID:7498791]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17914457]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:17914457]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:17914457]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807|PMID:17914457]" /experiment="EXISTENCE:genetic interaction:GO:0005096 GTPase activator activity [PMID:7498791]" /experiment="EXISTENCE:genetic interaction:GO:0031106 septin ring organization [PMID:14517318]" /experiment="EXISTENCE:genetic interaction:GO:0035024 negative regulation of Rho protein signal transduction [PMID:17914457]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:8013906]" /experiment="EXISTENCE:mutant phenotype:GO:0035024 negative regulation of Rho protein signal transduction [PMID:17914457]" /experiment="EXISTENCE:physical interaction:GO:0035024 negative regulation of Rho protein signal transduction [PMID:17914457]" /note="Rho GTPase activating protein (RhoGAP); involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly" /codon_start=1 /product="GTPase-activating protein BEM3" /protein_id="DAA11319.1" /db_xref="SGD:S000006036" /translation="MTDNLTTTHGGSTTLELLAQYNDHRSKKDKSIEHIEKGTCSGKE RNPSYDEIFTENIKLKLQVQEYETEIESLEKVIDMLQKNREASLEVVLEQVQNDSRDS YVNDQSFVLPPRSAERKAHIKSLNLPIPTLSPPLQQGSDVALETSVTPTVPQIGVTSN TSISRKHLQNMILNDEIEANSSFSSPKIINRSVSSPTKIHSEQLASPAASVTYTTSRI TIKSPNKGSKSPLQERLRSPQNPNRMTAVINNHLHSPLKASTSNNLDELTESKSQQLT NDAIQKNDRVYSSITSSAYTTGTPTSAAKSPSSLLEVKEGENKALGFSPASKEKLDDF TQLLDSSFGEEDLVNTDSKDPLSIKSTINESLPPPPAPPTFFSPTSSGNIKNSTPLSS HLASPVILNKKDDNFGAQSAKNLKKPVLTSSLPNLSTKLSTTSQNASLPPNPPVESSS KQKQLGETASIHSTNTLNTFSSTPQGSLKTLRRPHASSVSTVKSVAQSLKSDIPLFVQ PEDFGTIQIEVLSTLYRDNEDDLSILIAIIDRKSGKEMFKFSKSIHKVRELDVYMKSH VPDLPLPTLPDRQLFQTLSPTKVDTRKNILNQYYTSIFSVPEFPKNVGLKIAQFISTD TVMTPPMMDDNVKDGSLLLRRPKTLTGNSTWRVRYGILRDDVLQLFDKNQLTETIKLR QSSIELIPNLPEDRFGTRNGFLITEHKKSGLSTSTKYYICTETSKERELWLSAFSDYI DPSQSLSLSSSRNANDTDSASHLSAGTHHSKFGNATISATDTPSYVTDLTQEYNNNNN ISNSSNNIANSDGIDSNPSSHSNFLASSSGNAEEEKDSRRAKMRSLFPFKKLTGPASA MNHIGITISNDSDSPTSPDSIIKSPSKKLMEVSSSSNSSTGPHVSTAIFGSSLETCLR LSSHKYQNVYDLPSVVYRCLEYLYKNRGIQEEGIFRLSGSSTVIKTLQERFDKEYDVD LCRYNESIEAKDDEASPSLYIGVNTVSGLLKLYLRKLPHLLFGDEQFLSFKRVVDENH NNPVQISLGFKELIESGLVPHANLSLMYALFELLVRINENSKFNKMNLRNLCIVFSPT LNIPISMLQPFITDFACIFQGGEPVKEEEREKVDIHIPQV" gene complement(335953..337143) /locus_tag="YPL113C" mRNA complement(335953..337143) /locus_tag="YPL113C" /product="glyoxylate reductase" CDS complement(335953..337143) /locus_tag="YPL113C" /experiment="EXISTENCE:mutant phenotype:GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [PMID:17173333]" /note="Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene" /codon_start=1 /product="glyoxylate reductase" /protein_id="DAA11320.1" /db_xref="SGD:S000006034" /translation="MITSIDIADVTYSAKPRILVPYKTQWEVASHLPEYRKLAERVEF YKYEMSTKDDFVKFLETHRINGFWLTEEFFTVLGNPSSYIEFFPASLKVILVPWVGCD FIDGKLLRSKGITLCNIGPHAADHVTELAIFLAISCFRMTSFWEYCFKYVENGNVEQC KKYISSDSYEIVTDSYHGQEMKFPSRTDKCKPNKDRKVVHLAEKYTVGGKKMESPMNK KVLILGFGSIGQNIGSNLHKVFNMSIEYYKRTGPVQKSLLDYNAKYHSDLDDPNTWKN ADLIILALPSTASTNNIINRKSLAWCKDGVRIVNVGRGTCIDEDVLLDALESGKVASC GLDVFKNEETRVKQELLRRWDVTALPHIGSTVADMVIKQTLITLENVQDIFVEGGDGK YVLN" gene complement(337436..338620) /gene="PEX25" /locus_tag="YPL112C" mRNA complement(337436..338620) /gene="PEX25" /locus_tag="YPL112C" /product="Pex25p" CDS complement(337436..338620) /gene="PEX25" /locus_tag="YPL112C" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:12135984]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:12135984]" /experiment="EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:12135984]" /note="Peripheral peroxisomal membrane peroxin; required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with Pex27p; PEX25 has a paralog, PEX27, that arose from the whole genome duplication" /codon_start=1 /product="Pex25p" /protein_id="DAA11321.1" /db_xref="SGD:S000006033" /translation="MSQFGTTDIVSGSETPPYSGASYQDAQDDNTHPHSSDAGAEKFS AGSGSESHTESSRSDDEDSQAKTKMVDNITILKYILDSLSGRDKLAKIIKYALDILKL FIEKSKRNLTVLDPSVLTYYTKILKNLTVKVALRHPITVIKVLLLSLLRNFDKKIDFI SQQLSTFRYILRFGGTPFRVCSFLGKFNKTRKCNFQIDQIKKIWFNEASLREFLDLYY GIFDELDLLYKLKIWTNKSFYSFVSRQESLAWQYDILLSLKDHWLNLQSLQKRQLELE VQLKVQNNALLLSPILMHQAHKDDGSQSPIRKQLLNDLNVNNDAEVLIHKQLKAIKDE KTLVYLDIARLSFDCMANTSDILNLKTPKGTYAVLSLGSGLTGLVKLWITTKRSLCSS KD" gene complement(338848..338919) /gene="IMT2" /locus_tag="YNCP0006C" tRNA complement(338848..338919) /gene="IMT2" /locus_tag="YNCP0006C" /product="tRNA-Met" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006413 translational initiation [PMID:9023104]" /experiment="EXISTENCE:direct assay:GO:0016282 eukaryotic 43S preinitiation complex [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0033290 eukaryotic 48S preinitiation complex [PMID:17242201]" /experiment="EXISTENCE:direct assay:GO:0071074 eukaryotic initiation factor eIF2 binding [PMID:14698289]" /note="Methionine initiator tRNA (tRNA-Met); predicted by tRNAscan-SE analysis; one of four initiator methionine tRNAs in yeast that are functional for translation" /db_xref="SGD:S000006667" gene 339944..340945 /gene="CAR1" /locus_tag="YPL111W" /gene_synonym="LPH15" mRNA 339944..340945 /gene="CAR1" /locus_tag="YPL111W" /gene_synonym="LPH15" /product="arginase" CDS 339944..340945 /gene="CAR1" /locus_tag="YPL111W" /gene_synonym="LPH15" /EC_number="3.5.3.1" /experiment="EXISTENCE:direct assay:GO:0004053 arginase activity [PMID:2404017]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:205532]" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:1939179]" /experiment="EXISTENCE:direct assay:GO:0019547 arginine catabolic process to ornithine [PMID:2404017]" /experiment="EXISTENCE:direct assay:GO:0030145 manganese ion binding [PMID:1939179]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0090368 regulation of ornithine metabolic process [PMID:12679340]" /experiment="EXISTENCE:direct assay:GO:0090369 ornithine carbamoyltransferase inhibitor activity [PMID:12679340]" /experiment="EXISTENCE:mutant phenotype:GO:0004053 arginase activity [PMID:14582193]" /experiment="EXISTENCE:mutant phenotype:GO:0019547 arginine catabolic process to ornithine [PMID:14582193]" /experiment="EXISTENCE:mutant phenotype:GO:0090368 regulation of ornithine metabolic process [PMID:12679340]" /experiment="EXISTENCE:mutant phenotype:GO:0090369 ornithine carbamoyltransferase inhibitor activity [PMID:12679340]" /note="Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance" /codon_start=1 /product="arginase" /protein_id="DAA11322.1" /db_xref="SGD:S000006032" /translation="METGPHYNYYKNRELSIVLAPFSGGQGKLGVEKGPKYMLKHGLQ TSIEDLGWSTELEPSMDEAQFVGKLKMEKDSTTGGSSVMIDGVKAKRADLVGEATKLV YNSVSKVVQANRFPLTLGGDHSIAIGTVSAVLDKYPDAGLLWIDAHADINTIESTPSG NLHGCPVSFLMGLNKDVPHCPESLKWVPGNLSPKKIAYIGLRDVDAGEKKILKDLGIA AFSMYHVDKYGINAVIEMAMKAVHPETNGEGPIMCSYDVDGVDPLYIPATGTPVRGGL TLREGLFLVERLAESGNLIALDVVECNPDLAIHDIHVSNTISAGCAIARCALGETLL" gene complement(341068..344739) /gene="GDE1" /locus_tag="YPL110C" mRNA complement(341068..344739) /gene="GDE1" /locus_tag="YPL110C" /product="glycerophosphocholine phosphodiesterase" CDS complement(341068..344739) /gene="GDE1" /locus_tag="YPL110C" /EC_number="3.1.4.2" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0046475 glycerophospholipid catabolic process [PMID:16141200]" /experiment="EXISTENCE:mutant phenotype:GO:0047389 glycerophosphocholine phosphodiesterase activity [PMID:16141200]" /note="Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes" /codon_start=1 /product="glycerophosphocholine phosphodiesterase" /protein_id="DAA11323.1" /db_xref="SGD:S000006031" /translation="MKFGKTFANHRIPEWSSQYVGYKSLKKMIKEITRLQEDIYRAHN KNSYDEGRPPTKMRDSSNSAQNYLDSPKIQKLLASFFFAVDRDIEKVDTFYNSQYAEY KKRFERLLSSNQFNEIKSTLVVDANKEDAVAQTLLTKDTREMNMLLKGTSQASRLSYH KDDLIEIQSILAELRKQFRNLKWYAELNKRAFGKILKKLDKKVGTNQQMSTMKTRILP LQFANDSLITKDLSLLKTIWEQVTFRINSYERVMRSTSPNANANDNTEFFKIICVFIE EDDSKGLIRELTNLYSELSLIPTRIMISVLNKAALSKSLACIDAILKVIPSLNDSEDI NRRNFFHHHIIAIGKLIRKQEILSRKKKSQPSKYTNSEGEIVTDLRTLHTTLSAPAES DSITEEEKSSACTLSYILEELPIHLRPCLFQHDNYKRTPLHYSCQYGLSEVTKLIIKL MKEWNIWNEIPIDDVSAFGDAESLTPLHLCVLGAHPKTTEVLLQSLDPNVKLKSSSLL HLATEWNNYPLLHVLLSSKRFDINYQDNELHETPLYLACRLNFFEAAVCLLYNGADLE IREKLFGWTAIFVAAAEGFTDIVKLLIANNANFDIEDEGGWTPMEHAVLRGHLHIADM VQIRDELVTHPHSQLNSGSEEKEPLNEISAGELNERNENGNGGNKGSLGKLAGPIKSY GHRFLDNNESLILITLGSNDTRNKSPSISLSSEALAKVIGLETDCALSLVISCNDSID KSSVILDLPLDDNVDAVDFKVPFKVDYSHTLYFDIVPTYGTRSLETHNRIDCQKNNNN YVMARGVSMLNKSYSSVGVNRSILNGSVTVPIIANHTLEILGTLKFEYIIITPFEHPQ LPLERTETYWKSLVSTRVIGHRGLGKNNPNKSLQIGENTVESFIMAASLGASYVEFDV QLTKDNVPVVYHDFLVAETGVDIPMHELTLEQFLDLNNADKEHIQRGAGHSPHHVNGA DTALQKYRGRSVDDSDVSTLRRAWDLHDNDPNGKSNNAHWSDNRMRLTKTFKKNNFKG NARGHSIASSFVTLKELFKKIPANVGFNIECKFPMLDEAEEEELGQIMMEMNHWVDTV LKVVFDNANGRDIIFSSFHPDICIMLSLKQPVIPILFLTEGGSEQMADLRASSLQNGI RFAKKWNLLGIVSAAAPILKAPRLVQVVKSNGLVCVTYGVDNNDPENASIQIEAGVDA VIVDSVLAIRRGLTKKNEK" gene complement(345264..347389) /gene="CQD1" /locus_tag="YPL109C" /gene_synonym="MCO76" mRNA complement(join(345264..345444,345597..347389)) /gene="CQD1" /locus_tag="YPL109C" /gene_synonym="MCO76" /product="Cqd1p" CDS complement(join(345264..345444,345597..347389)) /gene="CQD1" /locus_tag="YPL109C" /gene_synonym="MCO76" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:37073556]" /experiment="EXISTENCE:direct assay:GO:0044289 mitochondrial inner-outer membrane contact site [PMID:37073556]" /experiment="EXISTENCE:genetic interaction:GO:0007005 mitochondrion organization [PMID:37073556]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:37073556]" /experiment="EXISTENCE:mutant phenotype:GO:0055091 phospholipid homeostasis [PMID:37073556]" /note="UbiB protein kinase-like family member; mitochondrial inner membrane protein that interacts with outer membrane proteins Por1p and Om14p to form a MICOS-independent mitochondrial contact site; role in mitochondrial organization; contributes to mitochondrial lipid homeostasis; controls the cellular distribution of coenzyme Q (CoQ); contains a potential mitochondrial targeting sequence and predicted transmembrane domain" /codon_start=1 /product="Cqd1p" /protein_id="DAA11324.1" /db_xref="SGD:S000006030" /translation="MSFLKFAYRNSWRYYSKSTRHFHKIPIRQFIIPTSIAFYLTQNS FPKQNCLIYNDSLKPDPKGDTFEMGLYVSSENELQEKLKSFRSAKITESRNKLIRYLR IFWFGFNDNIVEPVCTILRFLEISAIFLPLLLLYPISWFGHKLKITDTNITETRGSLI WCQLLRKALELAGPSFIKLGQWAGSRTDIFSHALCHELGKLHSNVTAHSLSFTLEKLS QALKVDKIEDAFDEFNRTPIGVGSIAQVYVGELSQKYIDKYDNIQIGKDGNRWCAIKI LHPNVRSQIRRDLKIMKFCADAINWIPTMEWLSLPSEVDQFSILMNIQLDLRIEALNL ERFNENFKNSIQVKFPKPFLPLSNRDVMFEEHVYGLSMEKFLSTKKQINDVELCKKVS DPFVDAFLQMLILDDFVHADLHPGNVIIRFVKTNKYGTNIISSELESYRITHDLRKKI EEDQDQDFVGKLKSVLTNYTPQICFIDTGIITELNEKNRINFIALFNALARFDGYRAG ELMIERSRTPETAIDKEVFAFKVEKLVDKVKQRTFTLGTVSIGDLLDQMLSMVRSHHV RMESDFVSVVVAILLLEGIGRQLDPNLDLFESSLPILREFGFKREAKSLLKDASTLSM LKIWVGLEVRQLMHLSMKQIYDLVRTDQLCPNY" gene 348446..348952 /locus_tag="YPL108W" mRNA 348446..348952 /locus_tag="YPL108W" /product="hypothetical protein" CDS 348446..348952 /locus_tag="YPL108W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Cytoplasmic hypothetical protein; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11325.1" /db_xref="SGD:S000006029" /translation="MKEASDREEAPKMVEKNYSTGFRKAHGEKDQSVTKPISLDGRTG EVIVRKSTGKTKIRKGQTEEEYTQQLQHYFEVEQGPVRTKVGWMDEVDPLVEIREGKY DISNKHQRQVLSGFCHRLFYQCKYKECLDLSTYFLGLFEPFNVKNKMKRELEELEYMI ERCRGHVL" gene 349119..349865 /gene="DPC25" /locus_tag="YPL107W" mRNA 349119..349865 /gene="DPC25" /locus_tag="YPL107W" /product="Dpc25p" CDS 349119..349865 /gene="DPC25" /locus_tag="YPL107W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="Putative mitochondrial hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; DPC25 is not an essential gene" /codon_start=1 /product="Dpc25p" /protein_id="DAA11326.1" /db_xref="SGD:S000006028" /translation="MIRNQGWSLLYRIYPVRRFTRYSRVDMTFEGNTQDISTSVEERM TTVFGGRLKGEPPRSTSRVLSGGTKKIAGVQVPAKPQEPDNCCMSGCVNCVWEIYSED LRDWKHRRKEAAEKIAGTKEKWPKDWNPPLGLLHMENVPVELREKKLETDSKKAEQPH DLSAIRSLFPKRKGPLPKSVLAAKRKNIALRHNYEQKDGGDQSVSESDADEGWEDIPV YVKAFAEFESKKRLQKIRRQEEIKKRTALV" gene complement(350194..352275) /gene="SSE1" /locus_tag="YPL106C" /gene_synonym="LPG3" /gene_synonym="MSI3" mRNA complement(350194..352275) /gene="SSE1" /locus_tag="YPL106C" /gene_synonym="LPG3" /gene_synonym="MSI3" /product="adenyl-nucleotide exchange factor SSE1" CDS complement(350194..352275) /gene="SSE1" /locus_tag="YPL106C" /gene_synonym="LPG3" /gene_synonym="MSI3" /experiment="EXISTENCE:direct assay:GO:0000774 adenyl-nucleotide exchange factor activity [PMID:17154545|PMID:16688212]" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:17154545|PMID:15028727]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:16688212]" /experiment="EXISTENCE:direct assay:GO:0042277 peptide binding [PMID:18539149]" /experiment="EXISTENCE:genetic interaction:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:29507114]" /experiment="EXISTENCE:genetic interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:29507114]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:15028727]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:10480867]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:31962153]" /note="ATPase component of heat shock protein Hsp90 chaperone complex; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; plays a role in prion propagation and determining prion variants; binds unfolded proteins; member of Hsp110 subclass of HSP70 proteins; deletion results in spindle elongation in S phase; SSE1 has a paralog, SSE2, that arose from the whole genome duplication" /codon_start=1 /product="adenyl-nucleotide exchange factor SSE1" /protein_id="DAA11327.1" /db_xref="SGD:S000006027" /translation="MSTPFGLDLGNNNSVLAVARNRGIDIVVNEVSNRSTPSVVGFGP KNRYLGETGKNKQTSNIKNTVANLKRIIGLDYHHPDFEQESKHFTSKLVELDDKKTGA EVRFAGEKHVFSATQLAAMFIDKVKDTVKQDTKANITDVCIAVPPWYTEEQRYNIADA ARIAGLNPVRIVNDVTAAGVSYGIFKTDLPEGEEKPRIVAFVDIGHSSYTCSIMAFKK GQLKVLGTACDKHFGGRDFDLAITEHFADEFKTKYKIDIRENPKAYNRILTAAEKLKK VLSANTNAPFSVESVMNDVDVSSQLSREELEELVKPLLERVTEPVTKALAQAKLSAEE VDFVEIIGGTTRIPTLKQSISEAFGKPLSTTLNQDEAIAKGAAFICAIHSPTLRVRPF KFEDIHPYSVSYSWDKQVEDEDHMEVFPAGSSFPSTKLITLNRTGDFSMAASYTDITQ LPPNTPEQIANWEITGVQLPEGQDSVPVKLKLRCDPSGLHTIEEAYTIEDIEVEEPIP LPEDAPEDAEQEFKKVTKTVKKDDLTIVAHTFGLDAKKLNELIEKENEMLAQDKLVAE TEDRKNTLEEYIYTLRGKLEEEYAPFASDAEKTKLQGMLNKAEEWLYDEGFDSIKAKY IAKYEELASLGNIIRGRYLAKEEEKKQAIRSKQEASQMAAMAEKLAAQRKAEAEKKEE KKDTEGDVDMD" gene complement(352863..355412) /gene="SYH1" /locus_tag="YPL105C" /gene_synonym="MYR1" mRNA complement(352863..355412) /gene="SYH1" /locus_tag="YPL105C" /gene_synonym="MYR1" /product="Syh1p" CDS complement(352863..355412) /gene="SYH1" /locus_tag="YPL105C" /gene_synonym="MYR1" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:18327588]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0051664 nuclear pore localization [PMID:18327588]" /note="hypothetical protein that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication" /codon_start=1 /product="Syh1p" /protein_id="DAA11328.1" /db_xref="SGD:S000006026" /translation="MNPINSLAFDLHSVKLADANSDTAALSNSNTPTMNNAALLQRPS SIMDSIGVQRVPSPFVPGSNAISGASTVPFNAYDAEITGSPLQISANQENNSAFSAAS SNLHMNASSPSVLNKPSSTFPNVAPYLYNATGPAPNVGNQPPPPGIESQWKYIDSNGN IQGPFGTNNMSQWYQGGYFTPTLQICRLATSPEPFGVNDRFIRLGELTTLVNNYQDPF VAFDFIVIRALNAVPLVAPTSSEKQKVESRDLIPVADVHSDDFTYEEILGLKFEDGSY YHETQVWVPVDGRHITKVDRIPKISAYTAPLSTTSSRSNKTTSSHEEKVPSHEEASPE EQEVFSEEGRTVSNITNEEESIVKNPTKQEEESRGSEKEQNILDQVQPEIEEVDRKDV ISTADEPKSKDTPQMTSEEQKRFAKAELMAQKLLEEQQRQEEEKKRREEQRKLKKEKK LKQKQKKEEEKLKKKKKEEGKLEKEKQKELLNNILTGDTETPSSENTATSITTNLAPW ANKKPEGAVYNQISSALEDLKKENSSKKEKKPNRTQLDREQALKLQKEILSSAQIPKT QTGSAWGIKPQQPIKVDIKGELMKDSTKINSQSKINKANNGDIKPDSTFIEEQKKLWE QVQKKTKKFNRASSLDDFISRTPSPSSSALNSSNTSNAWTTVSSKSTTHIASTMPVAG NQSKSYISLDTLRSSGGLSTATKTKMSDKSKQIGSSTSIPTLKARQVKPSRIPAYPGN ASVSKRQEFLRWCRSQLKLNTGVQPDNVLEMLLSLPPGSESKEIIADTIYSYSSTMDG RRFATDFIKKRLECEEEINDPLSWSEVLAMPEGSSEDWEFQVVGKKKGKRF" gene 355700..357676 /gene="MSD1" /locus_tag="YPL104W" /gene_synonym="LPG5" mRNA 355700..357676 /gene="MSD1" /locus_tag="YPL104W" /gene_synonym="LPG5" /product="aspartate--tRNA ligase MSD1" CDS 355700..357676 /gene="MSD1" /locus_tag="YPL104W" /gene_synonym="LPG5" /EC_number="6.1.1.12" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:genetic interaction:GO:0070146 mitochondrial aspartyl-tRNA aminoacylation [PMID:10710420]" /experiment="EXISTENCE:mutant phenotype:GO:0004815 aspartate-tRNA ligase activity [PMID:2668951]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:2668951]" /experiment="EXISTENCE:mutant phenotype:GO:0070146 mitochondrial aspartyl-tRNA aminoacylation [PMID:2668951]" /note="Mitochondrial aspartyl-tRNA synthetase; required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene" /codon_start=1 /product="aspartate--tRNA ligase MSD1" /protein_id="DAA11329.1" /db_xref="SGD:S000006025" /translation="MLARSRVCLQTITRRLADFPEANAIKKKFLFRKDTSTIKQLKGL SSGQKIVLNGWIEQKPKRVGKNLIFGLLRDSNGDIIQLVDNKSLLKGFTLEDVVQAVG ILSLKRKLSNEDADEYEVQLEDITVLNASNKKPAQMQDFKLSAIYPPEFRYLQLRNPK YQDFLKKRSSISKEIRNSFNNFDFTEVETPMLFKATPEGAREFLVPTRTKRSDGKPSF YALDQSPQQYKQLLMASGVNKYYQMARCFRDEDLRADRQPEFTQVDMEMAFANSEDVM KIIEKTVSGVWSKFSKKRGLLTLDSKGTLVPAKKENGTVSIFRMTYEQAMTSYGIDKP DLRAPDLKIINLGEFNAFSHLNKKFPVFEVIILRSAFSNMEEYKERWSFLTNNSNYNY RVPIVLPIENDEQANSNWFENFHAIATFENPHLITKFLKLKKGDIVCGCTREPNHSIF ENPTPLGRLRQLVLQSEHGKNIYHAVNKDVASWIVDFPLFSPVIIEDKSGKKEKLAYP EYEKDRLCSTHHPFTMVKLKDYEKLEKTPEKCLGRHYDLVVNGVELGGGSTRIHDPRL QDYIFEDILKIDNAYELFGHLLNAFDMGTPPHAGFAIGFDRMCAMICETESIRDVIAF PKSITGADLVVKSPSVIPESILEPYNIKYSNSKK" gene complement(358000..359406) /gene="FMP30" /locus_tag="YPL103C" mRNA complement(358000..359406) /gene="FMP30" /locus_tag="YPL103C" /product="N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D" CDS complement(358000..359406) /gene="FMP30" /locus_tag="YPL103C" /EC_number="3.1.4.54" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:21306442]" /experiment="EXISTENCE:mutant phenotype:GO:0070291 N-acylethanolamine metabolic process [PMID:15878693]" /experiment="EXISTENCE:mutant phenotype:GO:0070292 N-acylphosphatidylethanolamine metabolic process [PMID:15878693]" /note="Protein with a role in maintaining mitochondrial morphology; also involved in maintaining normal cardiolipin levels; mitochondrial inner membrane protein; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D" /codon_start=1 /product="N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D" /protein_id="DAA11330.1" /db_xref="SGD:S000006024" /translation="MNFVTCHVQMRLLLQRRLVRLRESELFRPQTSLSTFKRHASQKT RPIQKCSRKYARILLLSVLVPYTGYAFYVSLATVKQIDLRNEMCQRLEENNNEVTYKG SLLKYSPLEVLGRFENPFEEYRIQTVFEFFANRVFELFERNRGGIPRDVHQMNKLMPV HKPTWGPNLVDVDPAEETALPLECKVLDELHIPTAVEENEGSKCPVYNTWLGQSCNYT VYNGLRILTDPLFSDFLIHKTLGPKRITQMPSQITEVPKPDIILVSHNHPDHLDLESL EYWSGKDSPLWIVPKGMKSYMTSNGCDNVLELSWWETLQVKKNNEIYHISATPAMHWS GRSLLDTNKSLWCSFLLTHHGNPILFHAGDTGYVKDLFVRIKERFGKGCKLALLPCGQ YCPEWHQKPRHINPQEVLKIMKDLEARNVLGVHWGTFVLSGEYFLEPKEKLEMLAEWG GFKDRCYCPELGKTECFD" gene 360209..361579 /gene="ELP4" /locus_tag="YPL101W" /gene_synonym="HAP1" /gene_synonym="KTI9" /gene_synonym="TOT7" mRNA 360209..361579 /gene="ELP4" /locus_tag="YPL101W" /gene_synonym="HAP1" /gene_synonym="KTI9" /gene_synonym="TOT7" /product="Elongator subunit ELP4" CDS 360209..361579 /gene="ELP4" /locus_tag="YPL101W" /gene_synonym="HAP1" /gene_synonym="KTI9" /gene_synonym="TOT7" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:22343726]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:22343726]" /experiment="EXISTENCE:direct assay:GO:0033588 elongator holoenzyme complex [PMID:11689709]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11689709]" /note="Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; null mutation is functionally complemented by human ELP4" /codon_start=1 /product="Elongator subunit ELP4" /protein_id="DAA11331.1" /db_xref="SGD:S000006022" /translation="MSFRKRGEILNDRGSGLRGPLLRGPPRTSSTPLRTGNRRAPGNV PLSDTTARLKKLNIADESKTKMGLDSSHVGVRPSPATSQPTTSTGSADLDSILGHMGL PLGNSVLVEEQSTTEFHSILGKLFAAQGIVHNRISDSSADKTRNGDTHVIVLSLNQMF AKELPGIYKGSRKQMKKNLISEEESKVTVQNLNETQRSTPSRYKDLKIAWKYKLADEK RLGSPDRDDIQQNSEYKDYNHQFDITTRLMPAPIASELTFIAPTQPVSTILSQIEQTI KRNDKKLIRIVIPSLLHPAMYPPKMFESSEIIGLMHGVRSLVKKYYERVVLFASISID IITPPLLVLLRNMFDSVINLEPFNQEMTEFLERVYKSQPGKIQHGLVHILKLPVFTDR GEMRVLKSEWAFKNGRKKFEIEQWGIPVDDAEGSAASEQSHSHSHSDEISHNIPAKKT KISLDY" gene 361872..363362 /gene="ATG21" /locus_tag="YPL100W" /gene_synonym="HSV1" /gene_synonym="MAI1" mRNA 361872..363362 /gene="ATG21" /locus_tag="YPL100W" /gene_synonym="HSV1" /gene_synonym="MAI1" /product="Atg21p" CDS 361872..363362 /gene="ATG21" /locus_tag="YPL100W" /gene_synonym="HSV1" /gene_synonym="MAI1" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:15194695|PMID:11852075]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:25691244]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:18769150]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11852075]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:15155809|PMID:16876790]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:15155809]" /experiment="EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:15103325]" /experiment="EXISTENCE:mutant phenotype:GO:0000407 phagophore assembly site [PMID:25691244]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0006497 protein lipidation [PMID:15155809]" /experiment="EXISTENCE:mutant phenotype:GO:0016050 vesicle organization [PMID:15155809]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:15194695]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:16876790]" /experiment="EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:15155809|PMID:25691244]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /note="Phosphoinositide binding protein; required for vesicle formation in cytoplasm-to-vacuole targeting (CVT) pathway, autophagy, micronucleophagy and mitophagy; binds to several phosphoinositides including PtdIns(3,5)P2, PI3P and PI4P; involved in PI3P-dependent recruitment and organization of both Atg12-Atg5-Atg16 complex and Atg8p at pre-autophagosomal structure; necessary for oxidant-induced cell death; targeted to vacuole via AP-3 pathway; WD-40 repeat containing PROPPIN family member" /codon_start=1 /product="Atg21p" /protein_id="DAA11332.1" /db_xref="SGD:S000006021" /translation="MKVLQFNQDATCCVVAASSHQISIFNCDPFGKCFEIDTKNSKKK TSNNNGSASNSESRNNEESILITNGSRDRTDAEEEEDNEDNALVTGNILKEGEFVIEM LFSTSLIAIADRGQGLNKGKKLKIVNTKRKCTICEIVFPHEIVDVVMNRKRMCVLLES DQIFIYDISCMKPLETIDLWEDHYKRSQANSFSNASNTGTLEGDSANLNRVATNLLAN ATQKSVNGSNPSVRTRRNSLRSKIRPRMVLSNDDRSILCFTAYSSPKKNKPNSEALYD VVIYDTLNVTPVNYLNSVHKGNVACLAVSHDGKLLATASDKGTIIRVFHTGVDSDYMS SRSLFKEFRRGTRLCNLYQLAFDKSMTMIGCVGDTDTIHLFKLDDASNSLPGDNSSNG HWNEEEYILASNSNPSMGTPKEIPLSKPRIANYFSKKIKSSIPNQNLSRNFAYITVNE SNRSCLGFPDEFPNQVYIASDDGTFSIYSIPSKPGECVLTKNNKFT" gene complement(363520..364068) /gene="INA17" /locus_tag="YPL099C" /gene_synonym="AIM43" /gene_synonym="FMP14" mRNA complement(363520..364068) /gene="INA17" /locus_tag="YPL099C" /gene_synonym="AIM43" /gene_synonym="FMP14" /product="Ina17p" CDS complement(363520..364068) /gene="INA17" /locus_tag="YPL099C" /gene_synonym="AIM43" /gene_synonym="FMP14" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:26928762|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:24942160]" /experiment="EXISTENCE:direct assay:GO:1990524 INA complex [PMID:24942160]" /experiment="EXISTENCE:genetic interaction:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:24942160]" /experiment="EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:24942160]" /experiment="EXISTENCE:physical interaction:GO:1990524 INA complex [PMID:24942160]" /note="F1F0 ATPase synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex (Ina22p-Ina17p) involved in assembly of the F1F0 peripheral stalk; co-purifies with Ina22p and ATP synthase subunits; null mutant displays elevated frequency of mitochondrial genome loss and has a respiratory growth defect" /codon_start=1 /product="Ina17p" /protein_id="DAA11333.1" /db_xref="SGD:S000006020" /translation="MLKRRSNALITLSRTKLFPITTVAYYHRRLLNQQRRAVSTSPKK EIKSLEDLANLDSLDGVDTELIRDLINEHTTKLNIKKELDMLKKFSQEEESGHEIPVK RFIRPLWMFILMGSSVYLLLHFSWWKLEHEERESQLKKEVEILEHQLNELIVQDKTHN TSRGKGSNESTHMKPWYRRWFW" gene complement(364386..364727) /gene="MGR2" /locus_tag="YPL098C" mRNA complement(364386..364727) /gene="MGR2" /locus_tag="YPL098C" /product="Mgr2p" CDS complement(364386..364727) /gene="MGR2" /locus_tag="YPL098C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:22613836]" /experiment="EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:25454944]" /experiment="EXISTENCE:physical interaction:GO:0005744 TIM23 mitochondrial import inner membrane translocase complex [PMID:22613836]" /note="Core component of the TIM23 protein translocase complex; couples Tim21 with the core Tim23 translocase; provides quality control for membrane protein insertion, regulating their release into the inner membrane by the TIM23 complex; required for mitochondrial import of presequence-containing proteins at elevated temperature; forms the translocation path with Tim17p, sealing the lateral opening of the Tim17p cavity; required for viability of cells lacking the mitochondrial genome (petite-negative)" /codon_start=1 /product="Mgr2p" /protein_id="DAA11334.1" /db_xref="SGD:S000006019" /translation="MPPLPQNYAQQQPSNWDKFKMGLMMGTTVGVCTGILFGGFAIAT QGPGPDGVVRTLGKYIAGSAGTFGLFMSIGSIIRSDSESSPMSHPNLNLQQQARLEMW KLRAKYGIRKD" gene 364952..366430 /gene="MSY1" /locus_tag="YPL097W" mRNA 364952..366430 /gene="MSY1" /locus_tag="YPL097W" /product="tyrosine--tRNA ligase MSY1" CDS 364952..366430 /gene="MSY1" /locus_tag="YPL097W" /EC_number="6.1.1.1" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0004831 tyrosine-tRNA ligase activity [PMID:3315228]" /experiment="EXISTENCE:genetic interaction:GO:0070184 mitochondrial tyrosyl-tRNA aminoacylation [PMID:3315228]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:3315228]" /note="Mitochondrial tyrosyl-tRNA synthetase" /codon_start=1 /product="tyrosine--tRNA ligase MSY1" /protein_id="DAA11335.1" /db_xref="SGD:S000006018" /translation="MLELRSCSNLVNSSRRLVPLVTYSGLSAITLPKSRFYSQPSALE VQGTSDSRSDNILDELKQRGLVSQVSQPESFLRTKLNGNDKIKLYCGVDPTAQSLHLG NLVPLMVLLHFYVKGHDIVTVIGGATGKVGDPSGRKTERDVMENDIRQSNVASISQQL QRFFKNGLEYYRNRCALTEDVPSGKYTPRNNFNWWKDIKMLDFLADFGRHIRVQSMLA RDSISSRLQTKNGLGFNEFTYQVLQAYDFYHLYKEENVTIQVGGNDQWGNITAGIDLI NRIQPIKNKGLPFGITVPLLTTATGEKFGKSAGNAVFIDPSINTAYDVYQFFYNTLDA DVPKFLKIFTFLNSSEIKKIVETHIKSPSLRYGQTLLAKEVTDMLYGVGSGSDSEALS NIIFGRYDGTLSAAKLVDLCKKARILQYADREIDLIKLICKLVNCSVSEARRKLSQGS VYLHHSKSKVNENISNLAPFLIDDRVLILRIGKQKCFIIEMR" gene complement(366529..366735) /gene="ERI1" /locus_tag="YPL096C-A" /gene_synonym="RIN1" mRNA complement(366529..366735) /gene="ERI1" /locus_tag="YPL096C-A" /gene_synonym="RIN1" /product="Eri1p" CDS complement(366529..366735) /gene="ERI1" /locus_tag="YPL096C-A" /gene_synonym="RIN1" /experiment="EXISTENCE:direct assay:GO:0005095 GTPase inhibitor activity [PMID:12832483]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12832483]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:15163411]" /experiment="EXISTENCE:mutant phenotype:GO:0007265 Ras protein signal transduction [PMID:12832483]" /experiment="EXISTENCE:physical interaction:GO:0000506 glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex [PMID:15163411]" /note="Endoplasmic reticulum membrane protein that binds and inhibits Ras2p; binds to and inhibits GTP-bound Ras2p at the endoplasmic reticulum (ER); component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein" /codon_start=1 /product="Eri1p" /protein_id="DAA11336.1" /db_xref="SGD:S000028423" /translation="MRPRDQGFLVLGFTYSVLLISLATFYWLRNNDSFLHYWCVLLLC PATLWLWALIAWCDSEMFASSKDE" gene 366927..368018 /gene="PNG1" /locus_tag="YPL096W" mRNA 366927..368018 /gene="PNG1" /locus_tag="YPL096W" /product="peptide-N4-(N-acetyl-beta- glucosaminyl)asparagine amidase" CDS 366927..368018 /gene="PNG1" /locus_tag="YPL096W" /EC_number="3.5.1.52" /experiment="EXISTENCE:direct assay:GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity [PMID:10831608]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10831608]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10831608|PMID:15910746]" /experiment="EXISTENCE:direct assay:GO:0006517 protein deglycosylation [PMID:10831608]" /experiment="EXISTENCE:mutant phenotype:GO:0006515 protein quality control for misfolded or incompletely synthesized proteins [PMID:10831608]" /experiment="EXISTENCE:mutant phenotype:GO:0006517 protein deglycosylation [PMID:25497214|PMID:27433019]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:25497214]" /experiment="EXISTENCE:mutant phenotype:GO:0097466 ubiquitin-dependent glycoprotein ERAD pathway [PMID:27433019]" /note="Conserved peptide N-glycanase; deglycosylating enzyme that cleaves N-glycans that are attached to misfolded ERAD substrate glycoproteins prior to proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p; human ortholog NGLY1 is associated with a syndrome characterized by developmental delays, epilepsy, absence of tears and liver disease" /codon_start=1 /product="peptide-N4-(N-acetyl-beta- glucosaminyl)asparagine amidase" /protein_id="DAA11337.1" /db_xref="SGD:S000006017" /translation="MGEVYEKNNIDFDSIAKMLLIKYKDFILSKFKKAAPVENIRFQN LVHTNQFAQGVLGQSQHLCTVYDNPSWHSIVLETLDLDLIYKNVDKEFAKDGHAEGEN IYTDYLVKELLRYFKQDFFKWCNKPDCNHCGQNTSENMTPLGSQGPNGEESKFNCGTV EIYKCNRCGNITRFPRYNDPIKLLETRKGRCGEWCNLFTLILKSFGLDVRYVWNREDH VWCEYFSNFLNRWVHVDSCEQSFDQPYIYSINWNKKMSYCIAFGKDGVVDVSKRYILQ NELPRDQIKEEDLKFLCQFITKRLRYSLNDDEIYQLACRDEQEQIELIRGKTQETKSE SVSAASKSSNRGRESGSADWKAQRGEDGK" gene complement(368071..369441) /gene="EEB1" /locus_tag="YPL095C" mRNA complement(368071..369441) /gene="EEB1" /locus_tag="YPL095C" /product="medium-chain fatty acid ethyl ester synthase/esterase" CDS complement(368071..369441) /gene="EEB1" /locus_tag="YPL095C" /EC_number="2.3.1.84" /experiment="EXISTENCE:direct assay:GO:0004026 alcohol O-acetyltransferase activity [PMID:16361250]" /experiment="EXISTENCE:direct assay:GO:0034338 short-chain carboxylesterase activity [PMID:16361250]" /experiment="EXISTENCE:direct assay:GO:0051792 medium-chain fatty acid biosynthetic process [PMID:16361250]" /experiment="EXISTENCE:mutant phenotype:GO:0051792 medium-chain fatty acid biosynthetic process [PMID:16361250]" /experiment="EXISTENCE:mutant phenotype:GO:0051793 medium-chain fatty acid catabolic process [PMID:16361250]" /note="Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication" /codon_start=1 /product="medium-chain fatty acid ethyl ester synthase/esterase" /protein_id="DAA11338.1" /db_xref="SGD:S000006016" /translation="MFRSGYYPTVTPSHWGYNGTVKHVLGEKGTKSLAFRDSKRQIPL HEFVTKHVPTLKDGANFRLNSLLFTGYLQTLYLSAGDFSKKFQVFYGREIIKFSDGGV CTADWVMPEWEQTYSLNAEKASFNEKQFSNDEKATHPKGWPRLHPRTRYLSSEELEKC HSKGYSYPLVVVLHGLAGGSHEPLIRALSEDLSKVGDGKFQVVVLNARGCSRSKVTTR RIFTALHTGDVREFLNHQKALFPQRKIYAVGTSFGAAMLTNYLGEEGDNCPLNAAVAL SNPWDFVHTWDKLAHDWWSNHIFSRTLTQFLTRTVKVNMNELQVPENFEVSHKPTVEK PVFYTYTRENLEKAEKFTDILEFDNLFTAPSMGLPDGLTYYRKASSINRLPNIKIPTL IINATDDPVTGENVIPYKQARENPCVLLCETDLGGHLAYLDNESNSWLTKQAAEFLGS FDELVL" gene complement(369839..370663) /gene="SEC62" /locus_tag="YPL094C" /gene_synonym="LPG14" mRNA complement(369839..370663) /gene="SEC62" /locus_tag="YPL094C" /gene_synonym="LPG14" /product="Sec63 complex subunit SEC62" CDS complement(369839..370663) /gene="SEC62" /locus_tag="YPL094C" /gene_synonym="LPG14" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762|PMID:27831485]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:9252322]" /experiment="EXISTENCE:direct assay:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:7758110]" /experiment="EXISTENCE:physical interaction:GO:0031207 Sec62/Sec63 complex [PMID:2000150]" /note="Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; cotranslationally N-acetylated by NatA; other members are Sec63p, Sec66p, and Sec72p" /codon_start=1 /product="Sec63 complex subunit SEC62" /protein_id="DAA11339.1" /db_xref="SGD:S000006015" /translation="MSAVGPGSNAGASVNGGSATAIATLLRNHKELKQRQGLFQAKQT DFFRYKRFVRALHSEEYANKSARQPEIYPTIPSNKIEDQLKSREIFIQLIKAQMVIPV KKLHSQECKEHGLKPSKDFPHLIVSNKAQLEADEYFVWNYNPRTYMDYLIVIGVVSII LALVCYPLWPRSMRRGSYYVSLGAFGILAGFFAVAILRLILYVLSLIVYKDVGGFWIF PNLFEDCGVLESFKPLYGFGEKDTYSYKKKLKRMKKKQAKRESNKKKAINEKAEQN" gene 370978..372921 /gene="NOG1" /locus_tag="YPL093W" mRNA 370978..372921 /gene="NOG1" /locus_tag="YPL093W" /product="putative GTPase NOG1" CDS 370978..372921 /gene="NOG1" /locus_tag="YPL093W" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11112701]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:31909713]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23212245|PMID:11583614|PMID:16861225|PMID:17443350]" /experiment="EXISTENCE:direct assay:GO:0042273 ribosomal large subunit biogenesis [PMID:16888624]" /experiment="EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:12773575]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:12773575]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:17443350]" /experiment="EXISTENCE:mutant phenotype:GO:1902626 assembly of large subunit precursor of preribosome [PMID:31909713|PMID:22735702]" /note="Putative GTPase; associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins" /codon_start=1 /product="putative GTPase NOG1" /protein_id="DAA11340.1" /db_xref="SGD:S000006014" /translation="MQLSWKDIPTVAPANDLLDIVLNRTQRKTPTVIRPGFKITRIRA FYMRKVKYTGEGFVEKFEDILKGFPNINDVHPFHRDLMDTLYEKNHYKISLAAISRAK SLVEQVARDYVRLLKFGQSLFQCKQLKRAALGRMATIVKKLRDPLAYLEQVRQHIGRL PSIDPNTRTLLICGYPNVGKSSFLRCITKSDVDVQPYAFTTKSLYVGHFDYKYLRFQA IDTPGILDRPTEEMNNIEMQSIYAIAHLRSCVLYFMDLSEQCGFTIEAQVKLFHSIKP LFANKSVMVVINKTDIIRPEDLDEERAQLLESVKEVPGVEIMTSSCQLEENVMEVRNK ACEKLLASRIENKLKSQSRINNVLNKIHVAQPQARDDVKRTPFIPESVKNLKKYDPED PNRRKLARDIEAENGGAGVFNVNLKDKYLLEDDEWKNDIMPEILDGKNVYDFLDPEIA AKLQALEEEEEKLENEGFYNSDDEEEIYDGFEASEVDDIKEKAAWIRNRQKTMIAEAR NRKSLKNKAIMPRSKLTKSFGKMEEHMSTLGHDMSALQDKQNRAARKNRYVERGSDVV FGDQDALTASTENGVKLRQTDRLLDGVADGSMRSKADRMAKMERRERNRHAKQGESDR HNAVSLSKHLFSGKRGVGKTDFR" gene 373793..375169 /gene="SSU1" /locus_tag="YPL092W" /gene_synonym="LPG16" mRNA 373793..375169 /gene="SSU1" /locus_tag="YPL092W" /gene_synonym="LPG16" /product="Ssu1p" CDS 373793..375169 /gene="SSU1" /locus_tag="YPL092W" /gene_synonym="LPG16" /experiment="EXISTENCE:direct assay:GO:0000316 sulfite transmembrane transport [PMID:10870099]" /experiment="EXISTENCE:direct assay:GO:0000319 sulfite transmembrane transporter activity [PMID:10870099]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:9294463]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Plasma membrane sulfite pump involved in sulfite metabolism; required for efficient sulfite efflux; major facilitator superfamily protein" /codon_start=1 /product="Ssu1p" /protein_id="DAA11341.1" /db_xref="SGD:S000006013" /translation="MVANWVLALTRQFDPFMFMMVMGVGISSNILYSFPYPARWLRIC SYIMFAIACLIFIAVQALQILHLIVYIKEKSFREYFNDFFRNMKHNLFWGTYPMGLVT IINFLGALSKANTTKSPTNARNLMIFVYVLWWYDLAVCLVIAWGISFLIWHDYYPLEG IGNYPSYNIKMASENMKSVLLLDIIPLVVVASSCGTFTMSEIFFHAFNRNIQLITLVI CALTWLHAIIFVFILIAIYFWSLYINKIPPMTQVFTLFLLLGPMGQGSFGVLLLTDNI KKYAGKYYPTDNITREQEILTIAVPWCFKILGMVSAMALLAMGYFFTVISVVSILSYY NKKEIENETGKVKRVYTFHKGFWGMTFPMGTMSLGNEELYVQYNQYVPLYAFRVLGTI YGGVCVCWSILCLLCTLHEYSKKMLHAARKSSLFSESGTEKTTVSPYNSIESVEESNS ALDFTRLA" gene 375502..376953 /gene="GLR1" /locus_tag="YPL091W" /gene_synonym="LPG17" mRNA 375502..376953 /gene="GLR1" /locus_tag="YPL091W" /gene_synonym="LPG17" /product="glutathione-disulfide reductase GLR1" CDS 375502..376953 /gene="GLR1" /locus_tag="YPL091W" /gene_synonym="LPG17" /EC_number="1.8.1.7" /experiment="EXISTENCE:direct assay:GO:0004362 glutathione-disulfide reductase (NADPH) activity [PMID:19049979|PMID:7737505]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:23613772]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:23613772]" /experiment="EXISTENCE:genetic interaction:GO:0010731 protein glutathionylation [PMID:20074363]" /experiment="EXISTENCE:mutant phenotype:GO:0006749 glutathione metabolic process [PMID:23242256]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:8951820]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:23242256]" /note="Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; cytosolic Glr1p is the main determinant of the glutathione redox state of the mitochondrial intermembrane space; mitochondrial Glr1p has a role in resistance to hyperoxia; also detected in peroxisomes; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="glutathione-disulfide reductase GLR1" /protein_id="DAA11342.1" /db_xref="SGD:S000006012" /translation="MLSATKQTFRSLQIRTMSTNTKHYDYLVIGGGSGGVASARRAAS YGAKTLLVEAKALGGTCVNVGCVPKKVMWYASDLATRVSHANEYGLYQNLPLDKEHLT FNWPEFKQKRDAYVHRLNGIYQKNLEKEKVDVVFGWARFNKDGNVEVQKRDNTTEVYS ANHILVATGGKAIFPENIPGFELGTDSDGFFRLEEQPKKVVVVGAGYIGIELAGVFHG LGSETHLVIRGETVLRKFDECIQNTITDHYVKEGINVHKLSKIVKVEKNVETDKLKIH MNDSKSIDDVDELIWTIGRKSHLGMGSENVGIKLNSHDQIIADEYQNTNVPNIYSLGD VVGKVELTPVAIAAGRKLSNRLFGPEKFRNDKLDYENVPSVIFSHPEAGSIGISEKEA IEKYGKENIKVYNSKFTAMYYAMLSEKSPTRYKIVCAGPNEKVVGLHIVGDSSAEILQ GFGVAIKMGATKADFDNCVAIHPTSAEELVTMR" gene complement(377291..378395) /gene="RPS6A" /locus_tag="YPL090C" mRNA complement(join(377291..377995,378390..378395)) /gene="RPS6A" /locus_tag="YPL090C" /product="ribosomal 40S subunit protein S6A" CDS complement(join(377291..377995,378390..378395)) /gene="RPS6A" /locus_tag="YPL090C" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication" /codon_start=1 /product="ribosomal 40S subunit protein S6A" /protein_id="DAA11343.1" /db_xref="SGD:S000006011" /translation="MKLNISYPVNGSQKTFEIDDEHRIRVFFDKRIGQEVDGEAVGDE FKGYVFKISGGNDKQGFPMKQGVLLPTRIKLLLTKNVSCYRPRRDGERKRKSVRGAIV GPDLAVLALVIVKKGEQELEGLTDTTVPKRLGPKRANNIRKFFGLSKEDDVRDFVIRR EVTKGEKTYTKAPKIQRLVTPQRLQRKRHQRALKVRNAQAQREAAAEYAQLLAKRLSE RKAEKAEIRKRRASSLKA" gene complement(379120..381150) /gene="RLM1" /locus_tag="YPL089C" mRNA complement(379120..381150) /gene="RLM1" /locus_tag="YPL089C" /product="Rlm1p" CDS complement(379120..381150) /gene="RLM1" /locus_tag="YPL089C" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:9121433]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12410835]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:10064699]" /experiment="EXISTENCE:direct assay:GO:0033554 cellular response to stress [PMID:15116342]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:9121433]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15116342|PMID:9121433|PMID:12410835]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:7565726]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:12410835]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:20398213]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20398213|PMID:12410835]" /experiment="EXISTENCE:mutant phenotype:GO:0060256 regulation of flocculation [PMID:31441971]" /experiment="EXISTENCE:mutant phenotype:GO:1903450 regulation of G1 to G0 transition [PMID:31141453]" /note="MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication" /codon_start=1 /product="Rlm1p" /protein_id="DAA11344.1" /db_xref="SGD:S000006010" /translation="MGRRKIEIQRISDDRNRAVTFIKRKAGLFKKAHELSVLCQVDIA VIILGSNNTFYEFSSVDTNDLIYHYQNDKNLLHEVKDPSDYGDFHKSASVNINQDLLR SSMSNKPSKSNVKGMNQSENDDDENNDEDDDDHGNFERNSNMHSNKKASDKNIPSAHM KLLSPTALISKMDGSEQNKRHPENALPPLQHLKRLKPDPLQISRTPQQQQQQNISRPY HSSMYNLNQPSSSSSSPSTMDFPKLPSFQNSSFNGRPPPISISPNKFSKPFTNASSRT PKQEHKINNSGSNNNDNSNYTQSPSNSLEDSIQQTVKARRKLSARPVLRVRIPNNNFS SNSAIPSEPSSASSTSANGNSMGSSQIMKENKTSRSSKISPLSASASGPLTLQKGNNG RMVIKLPNANAPNGSNNGNGSNNNNHPYPFGSGSSPLFSATQPYIATPLQPSNIPGGP FQQNTSFLAQRQTQQYQQMSFKKQSQTVPLTTTLTGRPPSTFSGPETSNGPPTGSLPS KFVHDLMSNSPNVSSISMFPDWSMGPNSAKPGNTNNPGTFPPVQTAVNNGNSSNISST NNTNNNNNNNNNNSSNNNSNNGNDNNSNNSNNSYYSNNEDAPVNGAAISEHTTDGDSN NQSNSSTYDAAATAYNGNTGLTPYINTAQTPLGTKFFNFSTDISGEKNSSKI" gene 381965..382993 /locus_tag="YPL088W" mRNA 381965..382993 /locus_tag="YPL088W" /product="aldo-keto reductase superfamily protein" CDS 381965..382993 /locus_tag="YPL088W" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:31945465]" /note="Putative aryl alcohol dehydrogenase; localizes to cytosol; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance" /codon_start=1 /product="aldo-keto reductase superfamily protein" /protein_id="DAA11345.1" /db_xref="SGD:S000006009" /translation="MVLVKQVRLGNSGLKISPIVIGCMSYGSKKWADWVIEDKTQIFK IMKHCYDKGLRTFDTADFYSNGLSERIIKEFLEYYSIKRETVVIMTKIYFPVDETLDL HHNFTLNEFEELDLSNQRGLSRKHIIAGVENSVKRLGTYIDLLQIHRLDHETPMKEIM KALNDVVEAGHVRYIGASSMLATEFAELQFTADKYGWFQFISSQSYYNLLYREDEREL IPFAKRHNIGLLPWSPNARGMLTRPLNQSTDRIKSDPTFKSLHLDNLEEEQKEIINRV EKVSKDKKVSMAMLSIAWVLHKGCHPIVGLNTTARVDEAIAALQVTLTEEEIKYLEEP YKPQRQRC" gene 383455..384408 /gene="YDC1" /locus_tag="YPL087W" mRNA 383455..384408 /gene="YDC1" /locus_tag="YPL087W" /product="alkaline dihydroceramidase" CDS 383455..384408 /gene="YDC1" /locus_tag="YPL087W" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10900202]" /experiment="EXISTENCE:direct assay:GO:0017040 N-acylsphingosine amidohydrolase activity [PMID:10900202]" /experiment="EXISTENCE:genetic interaction:GO:0046513 ceramide biosynthetic process [PMID:11694577]" /experiment="EXISTENCE:mutant phenotype:GO:0046514 ceramide catabolic process [PMID:10900202]" /note="Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication" /codon_start=1 /product="alkaline dihydroceramidase" /protein_id="DAA11346.1" /db_xref="SGD:S000006008" /translation="MLFSWPYPEAPIEGYWGKPTSLIDWCEENYVVSPYIAEWSNTIT NSIFLMTAFYSTYSAWRNKLETRYILIGMGFSLVGIGSWLFHMTLQYRYQLLDELPML YATIIPSWSIFAETQEILIKDEKKRKESSFRIQMVISFIMCGIVTILTWIYVVVQKPA IFQVLYGILTLLVVVLSGWLTYYHVHDSFAKKNLFITMVMGMIPFVIGFICWQLDIHL CSFWIYIRRTYLALPLGVLLELHAWWHLLTGTGVYIFVVYLQYLRILTHGNPNDFLFI WRWGFFPELVRKGLPIGTSYSLEYLGPIVNTQVDDETKKNN" rep_origin 384542..384789 /note="ARS1618; Autonomously Replicating Sequence" /db_xref="SGD:S000118415" gene complement(384773..386446) /gene="ELP3" /locus_tag="YPL086C" /gene_synonym="HPA1" /gene_synonym="KAT9" /gene_synonym="KTI8" /gene_synonym="TOT3" mRNA complement(384773..386446) /gene="ELP3" /locus_tag="YPL086C" /gene_synonym="HPA1" /gene_synonym="KAT9" /gene_synonym="KTI8" /gene_synonym="TOT3" /product="Elongator subunit ELP3" CDS complement(384773..386446) /gene="ELP3" /locus_tag="YPL086C" /gene_synonym="HPA1" /gene_synonym="KAT9" /gene_synonym="KTI8" /gene_synonym="TOT3" /EC_number="2.3.1.311" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12139626]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12139626]" /experiment="EXISTENCE:direct assay:GO:0033588 elongator holoenzyme complex [PMID:11689709]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /note="Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin; human homolog ELP3 can partially complement yeast elp3 null mutant" /codon_start=1 /product="Elongator subunit ELP3" /protein_id="DAA11347.1" /db_xref="SGD:S000006007" /translation="MARHGKGPKTNKKKLAPEKERFIQCCADITLELTDSLTSGTTRE INLNGLITKYSKKYKLKQQPRLTDIINSIPDQYKKYLLPKLKAKPVRTASGIAVVAVM CKPHRCPHIAYTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPYEQARGR VEQLKQLGHSIDKVEYVLMGGTFMSLPKEYREDFIVKLHNALSGFNGNDIDEAILYSQ QSLTKCVGITIETRPDYCTQTHLDDMLKYGCTRLEIGVQSLYEDVARDTNRGHTVRSV CETFAVSKDAGYKVVSHMMPDLPNVGMERDIEQFKEYFENPDFRTDGLKIYPTLVIRG TGLYELWKTGRYKSYSANALVDLVARILALVPPWTRIYRVQRDIPMPLVTSGVDNGNL RELALARMKDLGTTCRDVRTREVGIQEVHHKVQPDQVELIRRDYYANGGWETFLSYED PKKDILIGLLRLRKASKKYTYRKEFTSQRTSIVRELHVYGSVVPLHSRDPRKFQHQGF GTLLMEEAERIAKEEHGSEKISVISGVGVRNYYGKLGYELDGPYMSKRI" gene 387067..393654 /gene="SEC16" /locus_tag="YPL085W" /gene_synonym="LPF1" mRNA 387067..393654 /gene="SEC16" /locus_tag="YPL085W" /gene_synonym="LPF1" /product="Sec16p" CDS 387067..393654 /gene="SEC16" /locus_tag="YPL085W" /gene_synonym="LPF1" /experiment="EXISTENCE:direct assay:GO:0012507 ER to Golgi transport vesicle membrane [PMID:7593161]" /experiment="EXISTENCE:direct assay:GO:0043495 protein-membrane adaptor activity [PMID:12235121|PMID:7593161]" /experiment="EXISTENCE:direct assay:GO:0048208 COPII vesicle coating [PMID:12235121]" /experiment="EXISTENCE:direct assay:GO:0070971 endoplasmic reticulum exit site [PMID:22675024]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:11694599]" /experiment="EXISTENCE:mutant phenotype:GO:0070973 protein localization to endoplasmic reticulum exit site [PMID:22675024]" /note="COPII vesicle coat protein required for ER transport vesicle budding; essential factor in endoplasmic reticulum exit site (ERES) formation, as well as in COPII-mediated ER-to-Golgi traffic; bound to periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p" /codon_start=1 /product="COPII coat assembly protein SEC16" /protein_id="DAA11348.1" /db_xref="SGD:S000006006" /translation="MTPEAKKRKNQKKKLKQKQKKAAEKAASHSEEPLELPESTINSS FNDDSVNRTESDIASKSDVPPVSSSTNISPANETQLEIPDTQELHHKLLNDSDQHDIT ADSNDLPDNSIVEHDSVITQTKPAMSQEYEETAAHLSSRNPSLDVVAGELHNNNEHTQ KIAVSAVEEDSFNEEEGENHDSIIISSLNDATPSQYNHFLPSDGNLLSPELSSGDTPT HNVPLGTKDNEINDDEYCNDKEISLNANNVLPDELSKEEDERLKLETHVSTEEKKQDI ADQETAENLFTSSTEPSENKIRNSGDDTSMLFQDDESDQKVPWEEDVKKDFHNENTNN TQESAPNTDDRDKGYEGNEALKKSESCTAADERSYSEETSEDIFHGHDKQVVEGQNDF TGKNIENESQKLMGEGNHKLPLSAEADIIEPGKDIQDQAEDLFTQSSGDLGEVLPWES TDKNADVTSKSQEKHEDLFAASGNDEKLPWEVSDGEVSSGKTENSMQTSTEKIAEQKF SFLENDDDLLDDDDSFLASSEEEDTVPNTDNTTNLTSKPVEEKKASRYKPIIEEEAGM RQEQVHFTNTTGIVTPQQFHGLTKTGLGTPNQQVSVPNIVSPKPPVVKDNRSNFKINE EKKKSDAYDFPLEIISESSKKGHAKPVAVPTQRFGSGNSFSSLDKPIPQSRKGSNNSN RPPVIPLGTQEPRSSRTNSAISQSPVNYAFPNPYKIQQLQQAPIQSGMPLPNTNIPPP ALKVETTVSAPPIRARGVSNASVGSSASFGARHATQYGLNNGVPPVSPYGQATINLPT ANKYAPVSPTVQQKQYPSVVQNLGASAVNTPNFVKTHRGHTSSISSYTPNQNEHASRY APNYQQSYQVPYTSQPVGPVAGNSSYQSQTRSSYAVPMMPQAQTSASIQPHANIQPPT GILPLAPLRPLDPLQAATNLQPRASNITAANSLPLANLPLAENILPEIITHRATSSVA PPRQENNPIKIDNEALLRRQFPIFHWSAANKVVYAVPPIPDQSQYMISSSIVQEIKVT PIDQIIKPNDMLKSFPGPLGSAKLKKKDLTKWMETTIKSISENESSTDMTIWQLLEMK LNDKVNWKNISKLLYNSDELLMYLSQPFPNGDMIPNAYRLDINCQMRVLAFLQTGNHD EALRLALSKRDYAIALLVGSLMGKDRWSEVIQKYLYEGFTAGPNDQKELAHFLLLIFQ VFVGNSKMAIKSFYTNNETSQWASENWKSIVAAVLINIPENNEDPLLIPPVVLEFLIE FGIFLTKKGLTAAASTLFIIGNVPLSNEPVMADSDVIFESIGNMNTFESILWDEIYEY IFSYDPKFKGFSSILPQKIYHASLLQEQGLNSLGTKYTDYLSSSVRKLPKKDILTINL TRELSEVASRLSESNTGWLAKPKLSSVWGQLDKSFNKYIGGDDIDALNKKNDKKKVFD GFTPGSSANSSTVDLTQTFTPFQAQVTSQSYVDTTALLHNAHNVPSHSVLHSKPSNVS KGLVEANLPYTHRIGDSLQGSPQRIHNTQFAAAEPQMASLRRVRTDQHTNEKALKSQQ ILEKKSTAYTPQFGQNHSVPMEKSNSNVPSLFADFPAPPKLGTVPSNYVSSPDLVRRE SIISTGSEFLPPPKIGVPTKANSSQGSLMYSPSVEALPIDPVVPQVHETGYNDFGNKH SQKSMPEDESHTSHDNSNADQNTLKDSADVTDETMDIEGPGFNDVKNLLPMEPNHQPT STVNPIQTISDDIQPILQTNVEVRGTDASKMENSLPSIENERSSEEQPENISKSASSA YLPSTGGLSLENRPLTQDENSISETVQSTYLPAGSISMEAKPISQVQDVPRNVNNKAS KLVEQHMAPPKPKSTDATKMNYSPYVPQSTAASADGDESTILKTSPAIYARTHQAHAS NPSQYFPLVNQANETASFELSESTSQAQSNGNVASENRFSPIKKAEVVEKDTFQPTIR KASTNQYRAFKPLESDADKYNDVIEDESDDDNMSTDEAKNRKEEKKNVNMKKETKPSN KDIDDKSNGWFGWLKKDTGDKKVYKAKLGHKNTLYYDEKLKRWVNKDATEEEKQKIIE SSAPPPPPIVKRKDGGPKTKPRSGPINNSLPPVHATSVIPNNPITGEPLPIKTSPSPT GPNPNNSPSPSSPISRISGVNLTSKKANGLDDLLSLAGGPKPASTRRKKKTARGYVNV MDNIQ" gene 394038..396572 /gene="BRO1" /locus_tag="YPL084W" /gene_synonym="ASI6" /gene_synonym="LPF2" /gene_synonym="NPI3" /gene_synonym="VPS31" mRNA 394038..396572 /gene="BRO1" /locus_tag="YPL084W" /gene_synonym="ASI6" /gene_synonym="LPF2" /gene_synonym="NPI3" /gene_synonym="VPS31" /product="Bro1p" CDS 394038..396572 /gene="BRO1" /locus_tag="YPL084W" /gene_synonym="ASI6" /gene_synonym="LPF2" /gene_synonym="NPI3" /gene_synonym="VPS31" /experiment="EXISTENCE:direct assay:GO:0005515 protein binding [PMID:34908216]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12668726]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:34908216|PMID:12668726|PMID:15935782]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0035800 deubiquitinase activator activity [PMID:17446860]" /experiment="EXISTENCE:direct assay:GO:1903003 positive regulation of protein deubiquitination [PMID:17446860]" /experiment="EXISTENCE:direct assay:GO:1903561 extracellular vesicle [PMID:38711329]" /experiment="EXISTENCE:genetic interaction:GO:0016579 protein deubiquitination [PMID:15326198]" /experiment="EXISTENCE:genetic interaction:GO:0070676 intralumenal vesicle formation [PMID:23444383]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:12062418]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:12668726]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:34908216]" /experiment="EXISTENCE:mutant phenotype:GO:0036010 protein localization to endosome [PMID:15326198]" /experiment="EXISTENCE:mutant phenotype:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:14523026]" /experiment="EXISTENCE:mutant phenotype:GO:0070676 intralumenal vesicle formation [PMID:23444383]" /experiment="EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:21070972]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /experiment="EXISTENCE:physical interaction:GO:0016579 protein deubiquitination [PMID:15326198]" /note="Cytoplasmic class E vacuolar protein sorting (VPS) factor; coordinates protein sorting and deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes; required for ESCRT-dependent transport of ubiquitinated cargo to the vacuole; localizes to extracellular vesicles during heat conditioning with proposed function in thermotolerance; orthologous to mammalian ESCRT-associated protein ALIX (PDCD6IP)" /codon_start=1 /product="Bro1p" /protein_id="DAA11349.1" /db_xref="SGD:S000006005" /translation="MKPYLFDLKLKDTEKLDWKKGLSSYLKKSYGSSQWRTFYDEKAT SELDHLRNNANGELAPSSLSEQNLKYYSFLEHLYFRLGSKGSRLKMDFTWYDAEYSSA QKGLKYTQHTLAFEKSCTLFNIAVIFTQIARENINEDYKNSIANLTKAFSCFEYLSEN FLNSPSVDLQSENTRFLANICHAEAQELFVLKLLNDQISSKQYTLISKLSRATCNLFQ KCHDFMKEIDDDVAIYGEPKWKTTVTCKLHFYKSLSAYYHGLHLEEENRVGEAIAFLD FSMQQLISSLPFKTWLVEFIDFDGFKETLEKKQKELIKDNDFIYHESVPAVVQVDSIK ALDAIKSPTWEKILEPYMQDVANKCDSLYRGIIPLDVYEKESIYSEEKATLLRKQVEE TETANLEYSSFIEFTNLPRLLSDLEKQFSDGNIFSNTDTQGQLMRDQIQTWCKFIQTN EFRDIEEQMNKIVFKRKQILEILSALPNDQKENVTKLKSSLVAASNSDEKLFACVKPH IVEINLLNDNGKIWKKFDEFNRNTPPQPSLLDIDDTKNDKILELLKQVKGHAEDLRTL KEERSRNLSELRDEINNDDITKLLIINKGKSDVELKDLFEVELEKFEPLSTRIEATIY KQSSMIDDIKAKLDEIFHLSNFKDKSSGEEKFLEDRKNFFDKLQEAVKSFSIFASDLP KGIEFYDSLFNMSRDLAERVRVAKQTEDSTANSPAPPLPPLDSKASVVGGPPLLPQKS AAFQSLSRQGLNLGDQFQNLKISAGSDLPQGPGIPPRTYEASPYAATPTMAAPPVPPK QSQEDMYDLRRRKAVENEERELQENPTSFYNRPSVFDENMYSKYSS" gene complement(396702..398105) /gene="SEN54" /locus_tag="YPL083C" mRNA complement(396702..398105) /gene="SEN54" /locus_tag="YPL083C" /product="tRNA splicing endonuclease subunit SEN54" CDS complement(396702..398105) /gene="SEN54" /locus_tag="YPL083C" /experiment="EXISTENCE:direct assay:GO:0000213 tRNA-intron endonuclease activity [PMID:9200603]" /experiment="EXISTENCE:direct assay:GO:0000214 tRNA-intron endonuclease complex [PMID:9200603]" /experiment="EXISTENCE:direct assay:GO:0000379 tRNA-type intron splice site recognition and cleavage [PMID:9200603]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:12925762|PMID:16407407]" /experiment="EXISTENCE:mutant phenotype:GO:0005741 mitochondrial outer membrane [PMID:12925762]" /note="Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface" /codon_start=1 /product="tRNA splicing endonuclease subunit SEN54" /protein_id="DAA11350.1" /db_xref="SGD:S000006004" /translation="MQFAGKKTDQVTTSNPGFEEEEEEEEELQQDWSQLASLVSKNAA LSLPKRGEKDYEPDGTNLQDLLLYNASKAMFDTISDSIRGTTVKSEVRGYYVPHKHQA VLLKPKGSFMQTMGRADSTGELWLDFHEFVYLAERGTILPYYRLEAGSNKSSKHETEI LLSMEDLYSLFSSQQEMDQYFVFAHLKRLGFILKPSNQEAAVKTSFFPLKKQRSNLQA ITWRLLSLFKIQELSLFSGFFYSKWNFFFRKYTTSPQLYQGLNRLVRSVAVPKNKKEL LDAQSDREFQKVKDIPLTFKVWKPHSNFKKRDPGLPDFQVFVYNKNDDLQHFPTYKEL RSMFSSLDYKFEFLSEIEDDDDWETNSYVEDIPRKEYIHKRSAKSQTEKSESSMKASF QKKTAQSSTKKKRKAYPPHIQQNRRLKTGYRSFIIAIMDNGLISFVKMSEADFGSESV WYTPNTQKKVDQRWKKH" gene complement(398480..404083) /gene="MOT1" /locus_tag="YPL082C" /gene_synonym="BUR3" /gene_synonym="END10" /gene_synonym="LPF4" mRNA complement(398480..404083) /gene="MOT1" /locus_tag="YPL082C" /gene_synonym="BUR3" /gene_synonym="END10" /gene_synonym="LPF4" /product="DNA-binding ATPase" CDS complement(398480..404083) /gene="MOT1" /locus_tag="YPL082C" /gene_synonym="BUR3" /gene_synonym="END10" /gene_synonym="LPF4" /experiment="EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:11880621]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:22298788]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21976730|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9234740]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:9234740]" /experiment="EXISTENCE:direct assay:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:17296733]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:17296733]" /experiment="EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:17296733]" /experiment="EXISTENCE:mutant phenotype:GO:0045892 negative regulation of DNA-templated transcription [PMID:24459134]" /experiment="EXISTENCE:mutant phenotype:GO:0045898 regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:21976730|PMID:15861138]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27226635]" /experiment="EXISTENCE:physical interaction:GO:0017025 TBP-class protein binding [PMID:8083216]" /note="Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity; may have a role in ensuring that soluble TBP is available to bind TATA-less promoters; forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA; coregulates transcription with Spt16p through assembly of preinitiation complex and organization of nucleosomes" /codon_start=1 /product="DNA-binding ATPase" /protein_id="DAA11351.1" /db_xref="SGD:S000006003" /translation="MTSRVSRLDRQVILIETGSTQVVRNMAADQMGDLAKQHPEDILS LLSRVYPFLLVKKWETRVTAARAVGGIVAHAPSWDPNESDLVGGTNEGSPLDNAQVKL EHEMKIKLEEATQNNQLNLLQEDHHLSSLSDWKLNEILKSGKVLLASSMNDYNVLGKA DDNIRKQAKTDDIKQETSMLNASDKANENKSNANKKSARMLAMARRKKKMSAKNTPKH PVDITESSVSKTLLNGKNMTNSAASLATSPTSNQLNPKLEITEQADESKLMIESTVRP LLEQHEIVAGLVWQFQGIYELLLDNLMSENWEIRHGAALGLRELVKKHAYGVSRVKGN TREENNLRNSRSLEDLASRLLTVFALDRFGDYVYDTVVAPVRESVAQTLAALLIHLDS TLSIKIFNCLEQLVLQDPLQTGLPNKIWEATHGGLLGIRYFVSIKTNFLFAHGLLENV VRIVLYGLNQSDDDVQSVAASILTPITSEFVKLNNSTIEILVTTIWSLLARLDDDISS SVGSIMDLLAKLCDHQEVLDILKNKALEHPSEWSFKSLVPKLYPFLRHSISSVRRAVL NLLIAFLSIKDDSTKNWLNGKVFRLVFQNILLEQNPELLQLSFDVYVALLEHYKVKHT EKTLDHVFSKHLQPILHLLNTPVGEKGKNYAMESQYILKPSQHYQLHPEKKRSISETT TDSDIPIPKNNEHINIDAPMIAGDITLLGLDVILNTRIMGAKAFALTLSMFQDSTLQS FFTNVLVRCLELPFSTPRMLAGIIVSQFCSSWLQKHPEGEKLPSFVSEIFSPVMNKQL LNRDEFPVFRELVPSLKALRTQCQSLLATFVDVGMLPQYKLPNVAIVVQGETEAGPHA FGVETAEKVYGEYYDKMFKSMNNSYKLLAKKPLEDSKHRVLMAINSAKESAKLRTGSI LANYASSILLFDGLPLKLNPIIRSLMDSVKEERNEKLQTMAGESVVHLIQQLLENNKV NVSGKIVKNLCGFLCVDTSEVPDFSVNAEYKEKILTLIKESNSIAAQDDINLAKMSEE AQLKRKGGLITLKILFEVLGPSILQKLPQLRSILFDSLSDHENEEASKVDNEQGQKIV DSFGVLRALFPFMSDSLRSSEVFTRFPVLLTFLRSNLSVFRYSAARTFADLAKISSVE VMAYTIREILPLMNSAGSLSDRQGSTELIYHLSLSMETDVLPYVIFLIVPLLGRMSDS NEDVRNLATTTFASIIKLVPLEAGIADPKGLPEELVASRERERDFIQQMMDPSKAKPF KLPIAIKATLRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIASDQYLRKE DYEKTRSVESRALPSLIICPPSLTGHWENEFDQYAPFLKVVVYAGGPTVRLTLRPQLS DADIIVTSYDVARNDLAVLNKTEYNYCVLDEGHIIKNSQSKLAKAVKEITANHRLILT GTPIQNNVLELWSLFDFLMPGFLGTEKMFQERFAKPIAASRNSKTSSKEQEAGVLALE ALHKQVLPFMLRRLKEDVLSDLPPKIIQDYYCELGDLQKQLYMDFTKKQKNVVEKDIE NSEIADGKQHIFQALQYMRKLCNHPALVLSPNHPQLAQVQDYLKQTGLDLHDIINAPK LSALRTLLFECGIGEEDIDKKASQDQNFPIQNVISQHRALIFCQLKDMLDMVENDLFK KYMPSVTYMRLDGSIDPRDRQKVVRKFNEDPSIDCLLLTTKVGGLGLNLTGADTVIFV EHDWNPMNDLQAMDRAHRIGQKKVVNVYRIITKGTLEEKIMGLQKFKMNIASTVVNQQ NSGLASMDTHQLLDLFDPDNVTSQDNEEKNNGDSQAAKGMEDIANETGLTGKAKEALG ELKELWDPSQYEEEYNLDTFIKTLR" gene 404950..406044 /gene="RPS9A" /locus_tag="YPL081W" mRNA join(404950..404956,405458..406044) /gene="RPS9A" /locus_tag="YPL081W" /product="ribosomal 40S subunit protein S9A" CDS join(404950..404956,405458..406044) /gene="RPS9A" /locus_tag="YPL081W" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:16540469]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0019843 rRNA binding [PMID:16540469]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication" /codon_start=1 /product="ribosomal 40S subunit protein S9A" /protein_id="DAA11352.1" /db_xref="SGD:S000006002" /translation="MPRAPRTYSKTYSTPKRPYESSRLDAELKLAGEFGLKNKKEIYR ISFQLSKIRRAARDLLTRDEKDPKRLFEGNALIRRLVRVGVLSEDKKKLDYVLALKVE DFLERRLQTQVYKLGLAKSVHHARVLITQRHIAVGKQIVNIPSFMVRLDSEKHIDFAP TSPFGGARPGRVARRNAARKAEASGEAADEADEADEE" gene complement(406172..406498) /locus_tag="YPL080C" mRNA complement(406172..406498) /locus_tag="YPL080C" /product="hypothetical protein" CDS complement(406172..406498) /locus_tag="YPL080C" /note="hypothetical protein; conserved across S. cerevisiae strains" /codon_start=1 /product="hypothetical protein" /protein_id="DAA80342.1" /db_xref="SGD:S000006001" /translation="MDGSYLTHRYCALKRPYTAHLLLLDFSKDEVTKNVWRWKGTDVK LHKMGRKSIVAAVYNQAHPSHPPLYHLGNLNGDKYVASPPSRMKAVSLSFAFTFLYYY FPLPTN" gene 406636..407539 /gene="RPL21B" /locus_tag="YPL079W" mRNA join(406636..406646,407068..407539) /gene="RPL21B" /locus_tag="YPL079W" /product="ribosomal 60S subunit protein L21B" CDS join(406636..406646,407068..407539) /gene="RPL21B" /locus_tag="YPL079W" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication" /codon_start=1 /product="ribosomal 60S subunit protein L21B" /protein_id="DAA11353.1" /db_xref="SGD:S000006000" /translation="MGKSHGYRSRTRYMFQRDFRKHGAVHMSTYLKIYKVGDIVDIKA NGSIQKGMPHKFYQGKTGVVYNVTKSSVGVIINKMVGNRYLEKRLNLRVEHIKHSKCR QEFLERVKANAAKRAEAKAQGVAVQLKRQPAQPRESRIVSTEGNVPQTLAPVPYETFI " gene complement(408010..408744) /gene="ATP4" /locus_tag="YPL078C" /gene_synonym="LPF7" mRNA complement(408010..408744) /gene="ATP4" /locus_tag="YPL078C" /gene_synonym="LPF7" /product="F1F0 ATP synthase subunit 4" CDS complement(408010..408744) /gene="ATP4" /locus_tag="YPL078C" /gene_synonym="LPF7" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0045265 proton-transporting ATP synthase, stator stalk [PMID:18722382]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:18293929]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:8068646]" /experiment="EXISTENCE:mutant phenotype:GO:0046961 proton-transporting ATPase activity, rotational mechanism [PMID:8068646]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:18293929]" /note="Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase; ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex, which in turn determines the shape of inner membrane cristae; phosphorylated" /codon_start=1 /product="F1F0 ATP synthase subunit 4" /protein_id="DAA11354.1" /db_xref="SGD:S000005999" /translation="MSMSMGVRGLALRSVSKTLFSQGVRCPSMVIGARYMSSTPEKQT DPKAKANSIINAIPGNNILTKTGVLGTSAAAVIYAISNELYVINDESILLLTFLGFTG LVAKYLAPAYKDFADARMKKVSDVLNASRNKHVEAVKDRIDSVSQLQNVAETTKVLFD VSKETVELESEAFELKQKVELAHEAKAVLDSWVRYEASLRQLEQRQLAKSVISRVQSE LGNPKFQEKVLQQSISEIEQLLSKLK" gene complement(409368..410090) /locus_tag="YPL077C" mRNA complement(409368..410090) /locus_tag="YPL077C" /product="hypothetical protein" CDS complement(409368..410090) /locus_tag="YPL077C" /note="hypothetical protein; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11355.1" /db_xref="SGD:S000005998" /translation="MKDLQKKSSVRRQITNEDDERYGEDSIHDLPRTIPNVNPYIRNS GFRPSYSSQIPSTRSLFNNYYNRSSANTVGNDTIDTDSVSYNGVAKFRRNSVDIPLQT HNRLEVRPIIDRQDYLWREIDALDDVKRQAQATELYDQFPPGFENKLMQLRQAHSKLL QVLRDRNAKIEEEQRREVAVATAAAMMTRTPSPTGKSVGDEATSNNMHSSSAIRNPNG PTVDPEEGKYIQELVNTIRELQ" gene 410443..411285 /gene="GPI2" /locus_tag="YPL076W" /gene_synonym="GCR4" mRNA 410443..411285 /gene="GPI2" /locus_tag="YPL076W" /gene_synonym="GCR4" /product="phosphatidylinositol N-acetylglucosaminyltransferase" CDS 410443..411285 /gene="GPI2" /locus_tag="YPL076W" /gene_synonym="GCR4" /EC_number="2.4.1.198" /experiment="EXISTENCE:curator inference:GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity []" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006506 GPI anchor biosynthetic process [PMID:7768896]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:7768896]" /experiment="EXISTENCE:physical interaction:GO:0000506 glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex [PMID:15163411]" /note="Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol" /codon_start=1 /product="phosphatidylinositol N-acetylglucosaminyltransferase" /protein_id="DAA11356.1" /db_xref="SGD:S000005997" /translation="MTRSPWKRLLWLKQEYPDNYTDPSFIELRARQKAESNQKSDRKL SEAARAQIRLDFISFYQTILNTSFIYITFTYIYYYGFDPIPPTIFLSFITLIISRTKV DPLLSSFMDVKSSLIITFAMLTLSPVLKSLSKTTASDSIWTLSFWLTLWYIFVISSTK SKDKPSNLSTNILVALVAVLSSRLSTTIDVFCFLLICIQLNIILPTYLSVTNKVVPII SNIIVYSFLNVALGWIYMLLIFFASVFYITVLPKWFIYWKINYHKRDNDLLSTWDART PILD" gene 412254..415362 /gene="GCR1" /locus_tag="YPL075W" /gene_synonym="LPF10" /gene_synonym="SIT3" mRNA join(412254..412261,413013..415362) /gene="GCR1" /locus_tag="YPL075W" /gene_synonym="LPF10" /gene_synonym="SIT3" /product="transcription regulator GCR1" CDS join(412254..412261,413013..415362) /gene="GCR1" /locus_tag="YPL075W" /gene_synonym="LPF10" /gene_synonym="SIT3" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:12655409|PMID:9271107|PMID:1588965|PMID:7808400|PMID :1946357|PMID:10455229|PMID:9335590]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:9335590]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15817685]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12655409]" /experiment="EXISTENCE:mutant phenotype:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:1588965]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:9271107]" /experiment="EXISTENCE:mutant phenotype:GO:0006110 regulation of glycolytic process [PMID:3547083|PMID:11333224|PMID:10510295|PMID:7808400]" /experiment="EXISTENCE:mutant phenotype:GO:0034728 nucleosome organization [PMID:2854200]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9335590|PMID:10510295|PMID:3547083|PMID:15789351|PMI D:7808400|PMID:11333224|PMID:10455229]" /experiment="EXISTENCE:mutant phenotype:GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:11333224]" /experiment="EXISTENCE:mutant phenotype:GO:0061435 positive regulation of transcription from a mobile element promoter [PMID:9271107]" /note="Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p; contains a long intron, which allows multiple RNA and protein isoforms with varying expression levels depending on glucose availability" /codon_start=1 /product="transcription regulator GCR1" /protein_id="DAA11357.1" /db_xref="SGD:S000005996" /translation="MVCTSTSSNFYSIAQYILQSYFKVNVDSLNSLKLVDLIVDQTYP DSLTLRKLNEGATGQPYDYFNTVSRDADISKCPIFALTIFFVIRWSHPNPPISIENFT TVPLLDSNFISLNSNPLLYIQNQNPNSNSSVKVSRSQTFEPSKELIDLVFPWLSYLKQ DMLLIDRTNYKLYSLCELFEFMGRVAIQDLRYLSQHPLLLPNIVTFISKFIPELFQNE EFKGIGSIKNSNNNALNNVTGIETQFLNPSTEEVSQKVDSYFMELSKKLTTENIRLSQ EITQLKADMNSVGNVCNQILLLQRQLLSGNQAIGSKSENIVSSTGGGILILDKNSINS NVLSNLVQSIDPNHSKPNGQAQTHQRGPKGQSHAQVQSTNSPALAPINMFPSLSNSIQ PMLGTLAPQPQDIVQKRKLPLPGSIASAATGSPFSPSPVGESPYSKRFKLDDKPTPSQ TALDSLLTKSISSPRLPLSTLANTAVTESFRSPQQFQHSPDFVVGGSSSSTTENNSKK VNEDSPSSSSKLAERPRLPNNDSTTSMPESPTEVAGDDVDREKPPESSKSEPNDNSPE SKDPEKNGKNSNPLGTDADKPVPISNIHNSTEAANSSGTVTKTAPSFPQSSSKFEIIN KKDTKAGPNEAIKYKLSRENKTIWDLYAEWYIGLNGKSSIKKLIENYGWRRWKVSEDS HFFPTRRIIMDYIETECDRGIKLGRFTNPQQPREDIRKILVGDLEKFRINNGLTLNSL SLYFRNLTKNNKEICIFENFKNWNVRSMTEEEKLKYCKRRHNTPS" gene 415763..418027 /gene="YTA6" /locus_tag="YPL074W" mRNA 415763..418027 /gene="YTA6" /locus_tag="YPL074W" /product="putative AAA family ATPase YTA6" CDS 415763..418027 /gene="YTA6" /locus_tag="YPL074W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:11553699]" /experiment="EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:32639961]" /note="Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress" /codon_start=1 /product="putative AAA family ATPase YTA6" /protein_id="DAA11358.1" /db_xref="SGD:S000005995" /translation="MAHEKFSIPENFTLAQSLQLLYSVVKNQYKNLADLIINSKGNKD TVTYGKIHKNLDTLLVYVNEGLRKIEKTYTLKKGLGNLVVDHPELRSIIEDFQILGQD IRIARRKAETLMAEGNGSPSLSSSSSVLGLGTGNGLRFPKLWRMGSKRDKLKEADEKE AKINKQADNIRRARKLEEEKKLGAKLQYERDLELQREKLIELKVKEKVEFEVAQKLEE ERVKREEEERKHREQAEKKRISTLKHERKTNYKSRASLDNFSSSSKSSGKIDNSLIKR RSLDVVRTSGERVRTPVRKSMEAAEIGMAAQLAWSQYQNGANHSKVSNNGSHSNELQI RYKPTPPLKKRYDYKKPTVNRPIIKSPTLNRQNSKSSRNIPTNSKLKASKSNTNKVSR RNEQNLEPSSPVLVSATAVPAESKPMRSKSGTPDKESSASSSLDSRKEDILKSVQGVD RNACEQILNEILVTDEKVYWEDIAGLRNAKNSLKEAVVYPFLRPDLFKGLREPVRGML LFGPPGTGKTMIAKAVATESNSTFFSVSASSLLSKYLGESEKLVRALFYMAKKLSPSI IFIDEIDSMLTARSDNENESSRRIKTELLIQWSSLSSATAQSEDRNNTLDSRVLVLGA TNLPWAIDDAARRRFSRKLYIPLPDYETRLYHLKRLMAKQKNSLQDLDYELITEMTEG FSGSDLTSLAKEAAMEPIRDLGDKLMFADFDKIRGIEIKDFQNALLTIKKSVSSESLQ KYEEWSSKFGSNGS" rep_origin 418138..418364 /note="ARS1619; Autonomously Replicating Sequence" /db_xref="SGD:S000118416" gene 418512..420011 /gene="UBP16" /locus_tag="YPL072W" mRNA 418512..420011 /gene="UBP16" /locus_tag="YPL072W" /product="putative ubiquitin-specific protease UBP16" CDS 418512..420011 /gene="UBP16" /locus_tag="YPL072W" /EC_number="3.4.19.12" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:12914939|PMID:16407407]" /note="Putative deubiquitinating enzyme anchored to the outer mitochondrial membrane; probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria" /codon_start=1 /product="putative ubiquitin-specific protease UBP16" /protein_id="DAA11359.1" /db_xref="SGD:S000005993" /translation="MSWIKNVTESPTSLIKKVSCGLIIAASLYAIAPSLSALVFGDSK QSIGKYTTVGLINRGNDCFITSSLQGLAGIPRFVEYLKRIRTVLLELETKLSNNAKGD NPTVDNTTRHSRLENSSNSLAPLHESLTSLILDLISVKDRKTSISPKIVINTLESIFK SKISSKQNDAHEFTLILLQTLQEERSKLIDYSKQICNLNIPKFPFEGETSKFLVCLKC KGLSEPSYKQTFIRELSVPQQTSENLSNILAHDETEIIDDYSCLICQIRAILNHEEYR NFKDCTPDEILMLDRLKNYATKAPINENLPFEVEQYVKRYSKGNLQVSNIKGKVIKKD VVVQLPDILIVHLSRSTFNGITYSRNPCNVKFGERITLSEYTLAESGTITENRQVKYN LKSVVKHTGSHSSGHYMCYRRKTEIRFGKEDESSFRRAPVVNNEVNKNREQNVAHNDY KKSRYKKVKNALRYPYWQISDTAIKESTASTVLNEQKYAYMLYYERVNK" gene complement(420048..420518) /locus_tag="YPL071C" mRNA complement(420048..420518) /locus_tag="YPL071C" /product="hypothetical protein" CDS complement(420048..420518) /locus_tag="YPL071C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11360.1" /db_xref="SGD:S000005992" /translation="MSSRFARSNGNPNHIRKRNHSPDPIGIDNYKRKRLIIDLENLSL NDKGPKNGHADDNNLIHNNIVFTDAIDDKVLKEIIKCSTSKRGDNDLFYDKIWERLRE KRLQIIKWVDYKEIAYLSWWKWFHNQMTSKYTYDGEADTDVEMMAVDTDVDMDA" gene 420948..422786 /gene="MUK1" /locus_tag="YPL070W" mRNA 420948..422786 /gene="MUK1" /locus_tag="YPL070W" /product="guanine nucleotide exchange factor MUK1" CDS 420948..422786 /gene="MUK1" /locus_tag="YPL070W" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:23612966|PMID:23264632]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:23612966|PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:23612966]" /experiment="EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:23612966]" /experiment="EXISTENCE:genetic interaction:GO:0036010 protein localization to endosome [PMID:23264632]" /note="Guanine nucleotide exchange factor (GEF); involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); specifically stimulates the intrinsic guanine nucleotide exchange activity of Rab family members (Vps21p/Ypt52p/Ypt53p); partially redundant with GEF VPS9; required for localization of the CORVET complex to endosomes; contains a VPS9 domain" /codon_start=1 /product="guanine nucleotide exchange factor MUK1" /protein_id="DAA11361.1" /db_xref="SGD:S000005991" /translation="MARQLFTPPITNPRFDPNQSIRESYKNTTGGMQFQQNLHEDQND NERSSCDGDENSTTGERLENNKSPILTKQEIDEALNTVTNLPPELSKLIDIFIDDLKQ PKYVRPLSVLQLSSLFQSFYIKFDKASFQHVSSANNNGYYFSGGGSSSFLAAKETLSS GLSGIFGRSRSSSGNSLMRPRRSSSLFSNESISNSTNATQMLSPEEIKKQLKINELNN MKIEKYMELCERDVFKKILIVGTSVSSPNKMKTFKPHQLQTFKVGNLFRNSVEFTEYN KLLNEKILCLSKLSTMNKINLIKFLSLNNGIDPEPKFEEIKDILYEFTYHSISPCEKI KALLKLHEIMTYSQEMSNDDYLSLLIYYIITIVPRDIFLNAEFIRLFRYKKKLVETES FALTNLEAALVFVEGLTKNDFSNELQDKLTVNESKILENSISSRVSLPSKTAIMHKNN GNNGSNLGDIVTPTIQRPDVTRSNSYDGFRTVFDSSLKNIIGKIRSYTPPHPNNTSNN NLHSSNNLNIPRSSSQLSMELSNRDTTEMSRDGSRSTSSSSRSSASLEHGNREFTGDL TVTASINGADKKEFQKSWKKYKGYKFEDLTICELRDLFEIYQKMMQ" rep_origin 422786..422885 /note="ARS1620; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay" /db_xref="SGD:S000130200" gene complement(422885..423892) /gene="BTS1" /locus_tag="YPL069C" mRNA complement(422885..423892) /gene="BTS1" /locus_tag="YPL069C" /product="farnesyltranstransferase" CDS complement(422885..423892) /gene="BTS1" /locus_tag="YPL069C" /EC_number="2.5.1.1" /EC_number="2.5.1.10" /EC_number="2.5.1.29" /experiment="EXISTENCE:direct assay:GO:0004311 geranylgeranyl diphosphate synthase activity [PMID:7665600]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016114 terpenoid biosynthetic process [PMID:7665600]" /experiment="EXISTENCE:mutant phenotype:GO:0016114 terpenoid biosynthetic process [PMID:7665600]" /note="Geranylgeranyl diphosphate synthase (GGPPS); increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic" /codon_start=1 /product="farnesyltranstransferase" /protein_id="DAA11362.1" /db_xref="SGD:S000005990" /translation="MEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIV QINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINT ANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQE MYLNMVMNKTGGLFRLTLRLMEALSPSSHHGHSLVPFINLLGIIYQIRDDYLNLKDFQ MSSEKGFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQ ILEFDTNSLAYTKNFINQLVNMIKNDNENKYLPDLASHSDTATNLHDELLYIIDHLSE L" gene complement(424215..425096) /locus_tag="YPL068C" mRNA complement(424215..425096) /locus_tag="YPL068C" /product="hypothetical protein" CDS complement(424215..425096) /locus_tag="YPL068C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11363.1" /db_xref="SGD:S000005989" /translation="MHMQLRKRKRVDYSGRNQTSDPPSTTTAAVPSIIVPKKRKVVAQ NMVSPAIRATTTTLGTSNIIIPKPLQRPKFHNSASLSSPDDDPEKISVLEVQKNLSNL IKRQQRLFYKDIHKPTLAGLKNFEMLRLPNDLKLLQNIVNLLYSFEQLNSDSKTRPVT TSKLKASSQAHSDKLKKMLAERKPPFSHPSHSGTAYHNDIIHEIANLHSINLVDLINL EVYNNNCHTNNTALQTTANSLTLNSIIKKLDKPILKERNNSLVWPHKSRFKAKRNQPS PGQSLINNTDITLYNDV" gene complement(425251..425847) /gene="HTC1" /locus_tag="YPL067C" mRNA complement(425251..425847) /gene="HTC1" /locus_tag="YPL067C" /product="Htc1p" CDS complement(425251..425847) /gene="HTC1" /locus_tag="YPL067C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene" /codon_start=1 /product="Htc1p" /protein_id="DAA11364.1" /db_xref="SGD:S000005988" /translation="MQQDIVNDHQEEAQGWKWEQIKEIIESGELARLKRSRQMTDKYH EHKKRTAGLDMNQYVLQKLGWSLDEPQLENAAAKAFSSSTLYAVRANDFPYNFEPGVV HLVLWSKVALPVHSPDKAVREAARARMNAFLQAQPLLRPLLSSGHVAWFVNYPELQSV ARIFHAHVLLFFPRERYSAEQVKTTVDDILSHGFEPLA" gene 426233..427672 /gene="RGL1" /locus_tag="YPL066W" mRNA 426233..427672 /gene="RGL1" /locus_tag="YPL066W" /product="Rgl1p" CDS 426233..427672 /gene="RGL1" /locus_tag="YPL066W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0097271 protein localization to bud neck [PMID:22344253]" /experiment="EXISTENCE:physical interaction:GO:0097271 protein localization to bud neck [PMID:22344253]" /note="Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source" /codon_start=1 /product="Rgl1p" /protein_id="DAA11365.1" /db_xref="SGD:S000005987" /translation="MTHPVISLKPSYNSVIRGCPGLPDTLPRIECQLRVRSNNSLPFK LVKIEIVLKTIEIYFNKNLYSSNNSSFTPFNRPSDPSNGHSDTSNQNISIHYKKNIVL SHPTHDGDDLNNDLIGIDIPLTIGLPDDIKETNYNPKFGKTQTFLDCTVFYTEVGGGS SNKKRNFLYPVNVERYTYLPSPSYFRPINRSNITSPDQKFLISYSIENPCVSMNNDTL KLSISIRLNPFPNNATTPSSNDFDVSTPTLFSTKKKFKSKLKLKSITTQILEYLEILK NQSEFSSTQTTNILQTSVRQVDQIISMNSMIFQFNLKIFTKDKILQSFRSSESSCPET KVLINKIDDIPLQYHSSITTIGQHFNVSHYLSIRFKFNKSLKNFEINHPLIISFWSVS QLPLIENLILQERQTAKFAKKFYKNFGRIKNTSNNNNSSNCLEYPSLPPIIYNFNDPE TNNRFNILYSQKDPSRTDPSKLRRVPVIQ" gene 427927..428655 /gene="VPS28" /locus_tag="YPL065W" /gene_synonym="VPL13" /gene_synonym="VPT28" mRNA 427927..428655 /gene="VPS28" /locus_tag="YPL065W" /gene_synonym="VPL13" /gene_synonym="VPT28" /product="ESCRT-I subunit protein VPS28" CDS 427927..428655 /gene="VPS28" /locus_tag="YPL065W" /gene_synonym="VPL13" /gene_synonym="VPT28" /experiment="EXISTENCE:direct assay:GO:0000813 ESCRT I complex [PMID:15044434]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:11511343]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:17215868]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:11511343]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:11511343]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /experiment="EXISTENCE:physical interaction:GO:0000813 ESCRT I complex [PMID:16615894|PMID:11511343]" /experiment="EXISTENCE:physical interaction:GO:0044877 protein-containing complex binding [PMID:17215868]" /note="Component of the ESCRT-I complex; complex is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p; other members include Stp22p, Srn2p, Vps28p, and Mvb12p" /codon_start=1 /product="ESCRT-I subunit protein VPS28" /protein_id="DAA11366.1" /db_xref="SGD:S000005986" /translation="MQKHNIKLNQNQDISQLFHDEVPLFDNSITSKDKEVIETLSEIY SIVITLDHVEKAYLKDSIDDTQYTNTVDKLLKQFKVYLNSQNKEEINKHFQSIEAFCD TYNITASNAITRLERGIPITAEHAISTTTSAPSGDNKQSSSSDKKFNAKYVAEATGNF ITVMDALKLNYNAKDQLHPLLAELLISINRVTRDDFENRSKLIDWIVRINKLSIGDTL TETQIRELLFDLELAYKSFYALLD" gene complement(428711..429616) /gene="CWC27" /locus_tag="YPL064C" mRNA complement(428711..429616) /gene="CWC27" /locus_tag="YPL064C" /product="putative peptidylprolyl isomerase CWC27" CDS complement(428711..429616) /gene="CWC27" /locus_tag="YPL064C" /EC_number="5.2.1.8" /experiment="EXISTENCE:direct assay:GO:0005684 U2-type spliceosomal complex [PMID:11884590]" /note="Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="putative peptidylprolyl isomerase CWC27" /protein_id="DAA11367.1" /db_xref="SGD:S000005985" /translation="MSSNIEPQTTAKCILYTTKGNIAIELWAKECPETCKRFLSMLSD GTFTNGEFKELKPTQWLMFNANSTGEYRTVAEEKNPRIRFNRDGLLGWDRRRNTWFIT VLADSKHVLNDCNVFGKIVGKSIYIFREILGGEIEASSRDNDVKRFMYPAVLKDVEIT IPFFEDIFGSKRRLEDNEKKEQEPAKKLVKSAKVKMVYEDEQEDDDGDVQKLKPRKRM ILPAWIKDDSRSEGIKLDASLDQPQEALIREKTELHDNVDEATTKETESQENIKEEPM DKRERETLAMLSKFQERIKNKNILK" gene 429939..431369 /gene="TIM50" /locus_tag="YPL063W" mRNA 429939..431369 /gene="TIM50" /locus_tag="YPL063W" /product="protein translocase subunit TIM50" CDS 429939..431369 /gene="TIM50" /locus_tag="YPL063W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005744 TIM23 mitochondrial import inner membrane translocase complex [PMID:12437924|PMID:12437925]" /experiment="EXISTENCE:direct assay:GO:0030943 mitochondrion targeting sequence binding [PMID:18418384|PMID:19144822]" /experiment="EXISTENCE:direct assay:GO:0046902 regulation of mitochondrial membrane permeability [PMID:16763150]" /experiment="EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:16763150]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:12437925|PMID:12437924]" /note="Essential component of the TIM23 complex; acts as receptor for the translocase of the inner mitochondrial membrane (TIM23) complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel" /codon_start=1 /product="protein translocase subunit TIM50" /protein_id="DAA11368.1" /db_xref="SGD:S000005984" /translation="MLSILRNSVRLNSRALRVVPSAANTLTSVQASRRLLTSYSSFLQ KETKDDKPKSILTDDMLFKAGVDVDEKGQGKNEETSGEGGEDKNEPSSKSEKSRRKRQ TSTDIKREKYANWFYIFSLSALTGTAIYMARDWEPQESEELKKDIDNGYTLSLMYKRF KARFNSMFTYFQEPPFPDLLPPPPPPPYQRPLTLVITLEDFLVHSEWSQKHGWRTAKR PGADYFLGYLSQYYEIVLFSSNYMMYSDKIAEKLDPIHAFVSYNLFKEHCVYKDGVHI KDLSKLNRDLSKVIIIDTDPNSYKLQPENAIPMEPWNGEADDKLVRLIPFLEYLATQQ TKDVRPILNSFEDKKNLAEEFDHRVKKLKDKFYGDHKSGGNWAMTALGLGNSLGGSTK FPLDLIHEEGQKNYLMFMKMIEEEKEKIRIQQEQMGGQTFTLKDYVEGNLPSPEEQMK IQLEKQKEVDALFEEEKKKKKIAESK" gene 431895..432299 /locus_tag="YPL062W" mRNA 431895..432299 /locus_tag="YPL062W" /product="hypothetical protein" CDS 431895..432299 /locus_tag="YPL062W" /experiment="EXISTENCE:mutant phenotype:GO:0032443 regulation of ergosterol biosynthetic process [PMID:30683746]" /experiment="EXISTENCE:mutant phenotype:GO:0051485 terpenoid biosynthetic process, mevalonate-dependent [PMID:30683746]" /note="hypothetical protein; conserved across S. cerevisiae strains; deletion decreases transcription of downstream gene ALD6; YPL062W is not an essential gene; null mutant shows decrease in terpenoid production; homozygous diploid mutant shows a decrease in glycogen accumulation" /codon_start=1 /product="hypothetical protein" /protein_id="DAA80343.1" /db_xref="SGD:S000005983" /translation="MIELDYVKGEDTIVEATSTSPWLMRSPLARAAEKRGSGLFFDIN EGHGQHRDVIVAYGVSKPKRRSPHPHGNKAADKRKTTEKEPERKKRVGAPRTCKKICI QLLYRFNFTVLGIGNVCNIDLLLGTVSATNAI" gene 432588..434090 /gene="ALD6" /locus_tag="YPL061W" /gene_synonym="ALD1" mRNA 432588..434090 /gene="ALD6" /locus_tag="YPL061W" /gene_synonym="ALD1" /product="aldehyde dehydrogenase (NADP(+)) ALD6" CDS 432588..434090 /gene="ALD6" /locus_tag="YPL061W" /gene_synonym="ALD1" /EC_number="1.2.1.4" /experiment="EXISTENCE:direct assay:GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity [PMID:9473035]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:16806052]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16806052]" /experiment="EXISTENCE:genetic interaction:GO:0006740 NADPH regeneration [PMID:12584194]" /experiment="EXISTENCE:mutant phenotype:GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity [PMID:9392076]" /experiment="EXISTENCE:mutant phenotype:GO:0005829 cytosol [PMID:9392076]" /experiment="EXISTENCE:mutant phenotype:GO:0009651 response to salt stress [PMID:15146068]" /experiment="EXISTENCE:mutant phenotype:GO:0019413 acetate biosynthetic process [PMID:11870853]" /note="Cytosolic aldehyde dehydrogenase; activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; localizes to the mitochondrial outer surface upon oxidative stress; negative regulator of nonselective autophagy; Stb5p directly regulates the expression of ALD6 mRNA and directly binds to the ALD6 promoter" /codon_start=1 /product="aldehyde dehydrogenase (NADP(+)) ALD6" /protein_id="DAA11369.1" /db_xref="SGD:S000005982" /translation="MTKLHFDTAEPVKITLPNGLTYEQPTGLFINNKFMKAQDGKTYP VEDPSTENTVCEVSSATTEDVEYAIECADRAFHDTEWATQDPRERGRLLSKLADELES QIDLVSSIEALDNGKTLALARGDVTIAINCLRDAAAYADKVNGRTINTGDGYMNFTTL EPIGVCGQIIPWNFPIMMLAWKIAPALAMGNVCILKPAAVTPLNALYFASLCKKVGIP AGVVNIVPGPGRTVGAALTNDPRIRKLAFTGSTEVGKSVAVDSSESNLKKITLELGGK SAHLVFDDANIKKTLPNLVNGIFKNAGQICSSGSRIYVQEGIYDELLAAFKAYLETEI KVGNPFDKANFQGAITNRQQFDTIMNYIDIGKKEGAKILTGGEKVGDKGYFIRPTVFY DVNEDMRIVKEEIFGPVVTVAKFKTLEEGVEMANSSEFGLGSGIETESLSTGLKVAKM LKAGTVWINTYNDFDSRVPFGGVKQSGYGREMGEEVYHAYTEVKAVRIKL" gene 434523..435764 /gene="MFM1" /locus_tag="YPL060W" /gene_synonym="LPE10" mRNA 434523..435764 /gene="MFM1" /locus_tag="YPL060W" /gene_synonym="LPE10" /product="Mfm1p" CDS 434523..435764 /gene="MFM1" /locus_tag="YPL060W" /gene_synonym="LPE10" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11254124]" /experiment="EXISTENCE:mutant phenotype:GO:0015095 magnesium ion transmembrane transporter activity [PMID:11254124]" /experiment="EXISTENCE:mutant phenotype:GO:0045016 mitochondrial magnesium ion transmembrane transport [PMID:11254124]" /note="Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p" /codon_start=1 /product="Mfm1p" /protein_id="DAA11370.1" /db_xref="SGD:S000005981" /translation="MRAFPRVLPFRHQRSYNNILLRTVRLFGSSLSSFDFSRQMPKVD PDNTAAMLLQKNLIQRNNMLYGYGSGTIRCTLLDSTGRAKSPLVEIKREDLVSKHGLL PRDLRKIEKSRKNDLVPSLLVRENSILISLLTVKALIKPDMVIIFDSAGSGITLNSEA HKDFINDMKLRLKNQETSELNSDPLPYEFRALETIFISALSNLTSEMKVLLTICKGVL QDLEFSITRDKLRFLLGQNKKLSSFNKKAVLVKDMLDDLLEQDDMLCDMYLTDKKAGK IRVQDDHTEIEMLLETYHNYVDEIVQKSESAISDVKTTEEIINIILDSNRNELMLLGI RYAIGMLSLGGALFLGSIYGMNLESFIEESNYAYLTVTILGLISTVWLYAKGIRHLHK LQRMTLLSKIKTDSVHELLKK" gene complement(435893..435964) /locus_tag="YNCP0007C" tRNA complement(435893..435964) /locus_tag="YNCP0007C" /product="tRNA-Cys" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Cysteine tRNA (tRNA-Cys), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006528" repeat_region 436068..436249 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007196" repeat_region complement(436250..436587) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007185" repeat_region 436594..436731 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007197" mobile_element complement(436890..443112) /note="YPLCTy4-1; Ty4 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats" /mobile_element_type="retrotransposon:YPLCTy4-1" /db_xref="SGD:S000007188" repeat_region complement(436890..437260) /note="Ty4 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007186" gene complement(437333..442742) /locus_tag="YPL060C-A" mRNA complement(437333..442742) /locus_tag="YPL060C-A" /product="gag-pol fusion protein" CDS complement(join(437333..439427,439429..442742)) /locus_tag="YPL060C-A" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /ribosomal_slippage /note="TyA Gag protein; the main structural constituent of virus-like particles (VLPs); Gag processing produces capsid proteins" /codon_start=1 /product="gag-pol fusion protein" /protein_id="DAA64692.1" /db_xref="SGD:S000007388" /translation="MATPVRDETRNVIDDNISARIQSKVKTNDTVRQTPSSLRKVSIK DEQVKQYQRNLNRFKTILNGLKAEEEKLSETDDIQMLAEKLLKLGETIDKVENRIVDL VEKIQLLETNENNNILHEHIDATGTYYLFDTLTSTNKRFYPKDCVFDYRTNNVENIPI LLNNFKKFIKKYQFDDVFENDIIEIDPRENEILCKIIKEGLGESLDIMNTNTTDIFRI IDGLKNKYRSLHGRDVRIRAWEKVLVDTTCRNSALLMNKLQKLVLMEKWIFSKCCQDC PNLKDYLQEAIMGTLHESLRNSVKQRLYNIPHNVGINHEEFLINTVIETVIDLSPIAD DQIENSCMYCKSVFHCSINCKKKPNRELRPDSTNFSKTYYLQGAQRQQQLKSSAKEQK SWNKTQKKSNKVYNSKKLVIIDTGSGVNITNDKTLLHNYEDSNRSTRFFGIGKNSSVS VKGYGYIKIKNGHNNTDNKCLLTYYVPEEESTIISCYDLAKKTKMVLSRKYTRLGNKI IKIKTKIVNGVIHVKMNELIERPSDDSKINAIKPTSSPGFKLNKRSITLEDAHKRMGH TGIQQIENSIKHNHYEESLDLIKEPNEFWCQTCKISKATKRNHYTGSMNNHSTDHEPG SSWCMDIFGPVSSSNADTKRYMLIMVDNNTRYCMTSTHFNKNAETILAQIRKNIQYVE TQFDRKVREINSDRGTEFTNDQIEEYFISKGIHHILTSTQDHAANGRAERYIRTIVTD ATTLLRQSNLRVKFWEYAVTSATNIRNCLEHKSTGKLPLKAISRQPVTVRLMSFLPFG EKGIIWNHNHKKLKPSGLPSIILCKDPNSYGYKFFIPSKNKIVTSDNYTIPNYTMDGR VRNTQNIYKSHQFSSHNDNEEDQIETVTNLCEALENYEDDNKPITRLEDLFTEEELSQ IDSNAKYPSPSNNLEGDLDYVFSDVEESGDYDVESELSTTNTSISTDKNKILSNKDFN SELASTEISISEIDKKGLINTSHIDEDKYDEKVHRIPSIIQEKLVGSKNTIKINDENR ISDRIRSKNIGSILNTGLSRCVDITDESITNKDESMHNAKPELIQEQFNKTNHETSFP KEGSIGTKCKIPKYRQWISLKTGDTSLPIKTLESINNHHSNDYSTNKVEKFEKENHHP PPIEDIVDMSDQTDMESNCQDGNNLKELKVTDKNVPTDNGTNVSPRLEQNIEASGSPV QTVNKSAFLNKEFSSLNMKRKRKRHDKNNSLTSYELERDKKRSKRNRVKLIPDNMETV SAQKIRAIYYNEAISKNPDLKEKHEYKQAYHKELQNLKDMKVFDVDVKYSRSEIPDNL IVPTNTIFTKKRNGIYKARIVCRGDTQSPDTYSVITTESLNHNHIKIFLMIANNRNMF MKTLDINHAFLYAKLEEEIYIPHPHDRRCVVKLNKALYGLKQSPKEWNDHLRQYLNGI GLKDNSYTPGLYQTEDKNLMIAVYVDDCVIAASNEQRLDEFINKLKSNFELKITGTLI DDVLDTDILGMDLVYNKRLGTIDLTLKSFINRMDKKYNEELKKIRKSSIPHMSTYKID PKKDVLQMSEEEFRQGVLKLQQLLGELNYVRHKCRYDINFAVKKVARLVNYPHERVFY MIYKIIQYLVRYKDIGIHYDRDCNKDKKVIAITDASVGSEYDAQSRIGVILWYGMNIF NVYSNKSTNRCVSSTEAELHAIYEGYADSETLKVTLKELGEGDNNDIVMITDSKPAIQ GLNRSYQQPKEKFTWIKTEIIKEKIKEKSIKLLKITGKGNIADLLTKPVSASDFKRFI QVLKNKITSQDILASTDY" repeat_region complement(442742..443112) /note="Ty4 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007187" gene 444579..445031 /gene="GRX5" /locus_tag="YPL059W" mRNA 444579..445031 /gene="GRX5" /locus_tag="YPL059W" /product="monothiol glutaredoxin GRX5" CDS 444579..445031 /gene="GRX5" /locus_tag="YPL059W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:11950925|PMID:15456753]" /experiment="EXISTENCE:direct assay:GO:0015036 disulfide oxidoreductase activity [PMID:12730244]" /experiment="EXISTENCE:direct assay:GO:0051537 2 iron, 2 sulfur cluster binding [PMID:23615440]" /experiment="EXISTENCE:genetic interaction:GO:0016226 iron-sulfur cluster assembly [PMID:11950925]" /experiment="EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:10567543]" /experiment="EXISTENCE:mutant phenotype:GO:0015036 disulfide oxidoreductase activity [PMID:10567543]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:11950925|PMID:12970193]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:10567543]" /experiment="EXISTENCE:mutant phenotype:GO:0044571 [2Fe-2S] cluster assembly [PMID:23615440]" /experiment="EXISTENCE:mutant phenotype:GO:0044572 [4Fe-4S] cluster assembly [PMID:23615440]" /note="Glutathione-dependent oxidoreductase; mitochondrial matrix protein involved at an early step in the biogenesis of iron-sulfur centers along with Bol1p; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p" /codon_start=1 /product="monothiol glutaredoxin GRX5" /protein_id="DAA11371.1" /db_xref="SGD:S000005980" /translation="MFLPKFNPIRSFSPILRAKTLLRYQNRMYLSTEIRKAIEDAIES APVVLFMKGTPEFPKCGFSRATIGLLGNQGVDPAKFAAYNVLEDPELREGIKEFSEWP TIPQLYVNKEFIGGCDVITSMARSGELADLLEEAQALVPEEEEETKDR" gene complement(445842..450377) /gene="PDR12" /locus_tag="YPL058C" mRNA complement(445842..450377) /gene="PDR12" /locus_tag="YPL058C" /product="ATP-binding cassette multidrug transporter PDR12" CDS complement(445842..450377) /gene="PDR12" /locus_tag="YPL058C" /experiment="EXISTENCE:direct assay:GO:0005342 organic acid transmembrane transporter activity [PMID:10419965]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:9687494]" /experiment="EXISTENCE:direct assay:GO:0015849 organic acid transport [PMID:10419965]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Plasma membrane ATP-binding cassette (ABC) transporter; weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity" /codon_start=1 /product="ATP-binding cassette multidrug transporter PDR12" /protein_id="DAA11372.1" /db_xref="SGD:S000005979" /translation="MSSTDEHIEKDISSRSNHDDDYANSVQSYAASEGQVDNEDLAAT SQLSRHLSNILSNEEGIERLESMARVISHKTKKEMDSFEINDLDFDLRSLLHYLRSRQ LEQGIEPGDSGIAFKNLTAVGVDASAAYGPSVEEMFRNIASIPAHLISKFTKKSDVPL RNIIQNCTGVVESGEMLFVVGRPGAGCSTFLKCLSGETSELVDVQGEFSYDGLDQSEM MSKYKGYVIYCPELDFHFPKITVKETIDFALKCKTPRVRIDKMTRKQYVDNIRDMWCT VFGLRHTYATKVGNDFVRGVSGGERKRVSLVEAQAMNASIYSWDNATRGLDASTALEF AQAIRTATNMVNNSAIVAIYQAGENIYELFDKTTVLYNGRQIYFGPADKAVGYFQRMG WVKPNRMTSAEFLTSVTVDFENRTLDIKPGYEDKVPKSSSEFEEYWLNSEDYQELLRT YDDYQSRHPVNETRDRLDVAKKQRLQQGQRENSQYVVNYWTQVYYCMIRGFQRVKGDS TYTKVYLSSFLIKALIIGSMFHKIDDKSQSTTAGAYSRGGMLFYVLLFASVTSLAEIG NSFSSRPVIVKHKSYSMYHLSAESLQEIITEFPTKFVAIVILCLITYWIPFMKYEAGA FFQYILYLLTVQQCTSFIFKFVATMSKSGVDAHAVGGLWVLMLCVYAGFVLPIGEMHH WIRWLHFINPLTYAFESLVSTEFHHREMLCSALVPSGPGYEGISIANQVCDAAGAVKG NLYVSGDSYILHQYHFAYKHAWRNWGVNIVWTFGYIVFNVILSEYLKPVEGGGDLLLY KRGHMPELGTENADARTASREEMMEALNGPNVDLEKVIAEKDVFTWNHLDYTIPYDGA TRKLLSDVFGYVKPGKMTALMGESGAGKTTLLNVLAQRINMGVITGDMLVNAKPLPAS FNRSCGYVAQADNHMAELSVRESLRFAAELRQQSSVPLEEKYEYVEKIITLLGMQNYA EALVGKTGRGLNVEQRKKLSIGVELVAKPSLLLFLDEPTSGLDSQSAWSIVQFMRALA DSGQSILCTIHQPSATLFEQFDRLLLLKKGGKMVYFGDIGPNSETLLKYFERQSGMKC GVSENPAEYILNCIGAGATASVNSDWHDLWLASPECAAARAEVEELHRTLPGRAVNDD PELATRFAASYMTQIKCVLRRTALQFWRSPVYIRAKFFECVACALFVGLSYVGVNHSV GGAIEAFSSIFMLLLIALAMINQLHVFAYDSRELYEVREAASNTFHWSVLLLCHAAVE NFWSTLCQFMCFICYYWPAQFSGRASHAGFFFFFYVLIFPLYFVTYGLWILYMSPDVP SASMINSNLFAAMLLFCGILQPREKMPAFWRRLMYNVSPFTYVVQALVTPLVHNKKVV CNPHEYNIMDPPSGKTCGEFLSTYMDNNTGYLVNPTATENCQYCPYTVQDQVVAKYNV KWDHRWRNFGFMWAYICFNIAAMLICYYVVRVKVWSLKSVLNFKKWFNGPRKERHEKD TNIFQTVPGDENKITKK" gene complement(451909..453057) /gene="SUR1" /locus_tag="YPL057C" /gene_synonym="BCL21" /gene_synonym="CSG1" /gene_synonym="LPE15" mRNA complement(451909..453057) /gene="SUR1" /locus_tag="YPL057C" /gene_synonym="BCL21" /gene_synonym="CSG1" /gene_synonym="LPE15" /product="mannosylinositol phosphorylceramide synthase catalytic subunit SUR1" CDS complement(451909..453057) /gene="SUR1" /locus_tag="YPL057C" /gene_synonym="BCL21" /gene_synonym="CSG1" /gene_synonym="LPE15" /EC_number="2.4.1.370" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347]" /experiment="EXISTENCE:mutant phenotype:GO:0006675 mannosyl-inositol phosphorylceramide metabolic process [PMID:9323360]" /experiment="EXISTENCE:mutant phenotype:GO:0006688 glycosphingolipid biosynthetic process [PMID:9323360]" /experiment="EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:12954640]" /experiment="EXISTENCE:mutant phenotype:GO:0103064 inositol phosphorylceramide mannosyltransferase activity [PMID:12954640]" /note="Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication" /codon_start=1 /product="mannosylinositol phosphorylceramide synthase catalytic subunit SUR1" /protein_id="DAA11373.1" /db_xref="SGD:S000005978" /translation="MRKELKYLICFNILLLLSIIYYTFDLLTLCIDDTVKDAILEEDL NPDAPPKPQLIPKIIHQTYKTEDIPEHWKEGRQKCLDLHPDYKYILWTDEMAYEFIKE EYPWFLDTFENYKYPIERADAIRYFILSHYGGVYIDLDDGCERKLDPLLAFPAFLRKT SPLGVSNDVMGSVPRHPFFLKALKSLKHYDKYWFIPYMTIMGSTGPLFLSVIWKQYKR WRIPKNGTVRILQPAYYKMHSYSFFSITKGSSWHLDDAKLMKALENHILSCVVTGFIF GFFILYGEFTFYCWLCSKNFSNLTKNWKLNAIKVRFVTILNSLGLRLKLSKSTSDTAS ATLLARQQKRLRKDSNTNIVLLKSSRKSDVYDLEKNDSSKYSLGNNSS" gene complement(453430..453735) /gene="LCL1" /locus_tag="YPL056C" mRNA complement(453430..453735) /gene="LCL1" /locus_tag="YPL056C" /product="Lcl1p" CDS complement(453430..453735) /gene="LCL1" /locus_tag="YPL056C" /note="hypothetical protein; deletion mutant is fluconazole resistant and has long chronological lifespan" /codon_start=1 /product="Lcl1p" /protein_id="DAA11374.1" /db_xref="SGD:S000005977" /translation="MKNAALCEALPLLATCSHEIPPTPHTVCFVFPPALLLSPSKLTL LNSRRVASRCVIIIDPRLLRLFSCSRPQQLPRDKNQSFAKPSFSFFFFLLTSLLSPF" gene complement(453992..454990) /gene="LGE1" /locus_tag="YPL055C" mRNA complement(453992..454990) /gene="LGE1" /locus_tag="YPL055C" /product="Lge1p" CDS complement(453992..454990) /gene="LGE1" /locus_tag="YPL055C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:32214243|PMID:14562095|PMID:15528187]" /experiment="EXISTENCE:direct assay:GO:0140693 molecular condensate scaffold activity [PMID:32214243]" /experiment="EXISTENCE:mutant phenotype:GO:0006279 premeiotic DNA replication [PMID:18069899]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:physical interaction:GO:0140693 molecular condensate scaffold activity [PMID:32214243]" /note="Protein that facilitates co-transcriptional histone H2B ubiquitination; scaffold protein that promotes oligomerization of E3 ligase Bre1p; contains an intrinsically disordered region that phase separates, to form a core encapsulated by Bre1p that recruits Ub-conjugating enzyme Rad6p, elevating catalytic activity along gene bodies; null mutant forms abnormally large cells, and homozygous null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division" /codon_start=1 /product="Lge1p" /protein_id="DAA11375.1" /db_xref="SGD:S000005976" /translation="MSGYTGNNYSRYSSTPPRQRGGYHHARRSRGGAGGSYYRGGNAS YGARYNSDYEQPPQEGDLRQTGAYYRNGYTDTRPYYSANSRHYQAQPSPRYNNGTNSY HLPQRGNSQDTNGRTTSASQEDNDEKRVKSRYRNMQADHPRQQPMSVGSTSSRNGSSG NSSTSSTSNGLPPPPSVSSITNNRSYHSSAYPYSSSHTYNNYHHRETPPPPPSNGYYA KGYPVHVPENRSNSDGSSSSVVKKKRILDMKDSPFIYLTDFDKNVKKTNNTESECEKA REVFKESDSIDSALEELNLKINSNELELRLLNNQCDKHALNIQLTQEKLDSLLLMQ" gene 455759..456664 /gene="LEE1" /locus_tag="YPL054W" mRNA 455759..456664 /gene="LEE1" /locus_tag="YPL054W" /product="Lee1p" CDS 455759..456664 /gene="LEE1" /locus_tag="YPL054W" /note="Zinc-finger hypothetical protein" /codon_start=1 /product="Lee1p" /protein_id="DAA11376.1" /db_xref="SGD:S000005975" /translation="MDAFENMSVSNHPGGNARRNSQSANEMLASQIQDFQNIPRSFND SNANVNLSKNCTVGNQLPFSSRQQKIIMEHLLITKNNSQQQKDYSHVPCKFFKMGNCQ AGSSCPFSHSPDIISSANNLPCKYFAKGNCKFGNKCVNAHVLPNGFKMNSKEPIDITP PSQNNYLSHARSASFSTYTSPPLSAQTEFSHSASNANYFSSQYLMYSPQKSPEALYTE FFSPPSSSSSYINYSYNNSNINAYSPVSSSSSNIWQEQGQTTLSNPSVNQNLRYRTGP AIQEESDNEIEDLLIHNFNSRYCHE" rep_origin 456563..456810 /note="ARS1633; Autonomously Replicating Sequence" /db_xref="SGD:S000119038" gene complement(457118..458458) /gene="KTR6" /locus_tag="YPL053C" /gene_synonym="MNN6" mRNA complement(457118..458458) /gene="KTR6" /locus_tag="YPL053C" /gene_synonym="MNN6" /product="putative mannosyltransferase" CDS complement(457118..458458) /gene="KTR6" /locus_tag="YPL053C" /gene_synonym="MNN6" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:30842360]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:9218445]" /experiment="EXISTENCE:mutant phenotype:GO:0000031 mannosylphosphate transferase activity [PMID:9218445]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:9218445]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:30842360]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:9090056]" /note="Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; facilitates the exit of Mnn4p from the ER via COPII-coated vesicles; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication" /codon_start=1 /product="putative mannosyltransferase" /protein_id="DAA11377.1" /db_xref="SGD:S000005974" /translation="MHVLLSKKIARFLLISFVFVLALMVTINHPKTKQMSEQYVTPYL PKSLQPIAKISAEEQRRIQSEQEEAELKQSLEGEAIRNATVNAIKEKIKSYGGNETTL GFMVPSYINHRGSPPKACFVSLITERDSMTQILQSIDEVQVKFNKNFAYPWVFISQGE LDGMKQEMIRQAITDSMNGDPELINIKFAEIPADEWVYPEWIDENKAAESLISLANVP DGDSRAVRYQARYFAGFFWRHPVLDEFDWYWRVDPGIKLYCDIDHDLFRWMQDEGKVF GFTLSMSEAKEANEKIWDVTKKFAKDFPKFISENNFKSFITKKDSEDFNNCEFTSNFE IGNLNFYRSPAYRKFFNYIDEEGGIFYWKWSDSIIHTIGLSMLLPKDKIHFFENIGFH YDKYNNCPLNDDIWNQYNCNCDQGNDFTFRSGSCGGHYFDIMKKDKPEGWDRLP" gene 458799..459678 /gene="OAZ1" /locus_tag="YPL052W" /gene_synonym="YPL052W-A" mRNA 458799..459678 /gene="OAZ1" /locus_tag="YPL052W" /gene_synonym="YPL052W-A" /product="Oaz1p" CDS join(458799..459005,459007..459678) /gene="OAZ1" /locus_tag="YPL052W" /gene_synonym="YPL052W-A" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:15538383]" /experiment="EXISTENCE:direct assay:GO:0008073 ornithine decarboxylase inhibitor activity [PMID:15538383]" /experiment="EXISTENCE:direct assay:GO:0061136 regulation of proteasomal protein catabolic process [PMID:18089576]" /experiment="EXISTENCE:mutant phenotype:GO:2001125 negative regulation of translational frameshifting [PMID:21900894]" /ribosomal_slippage /note="Regulator of ornithine decarboxylase Spe1p; antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p" /codon_start=1 /product="Oaz1p" /protein_id="DAA11378.1" /db_xref="SGD:S000005973" /translation="MYEVIQKRKTKIINVLQSPELMRLIEDPSNLGISLHFPVSSLLK SNKCTPMPKLSTYSLASGGFKDWCADIPLDVPPEIDIIDFYWDVILCMESQFILDYNV PSKNKGNNQKSVAKLLKNKLVNDMKTTLKRLIYNENTKQYKNNNSHDGYNWRKLGSQY FILYLPLFTQELIWCKLNENYFHVVLPSLLNSRNVHDNHSTYINKDWLLALLELTSNL NQNFKFEYMKLRLYILRDDLINNGLDLLKNLNWVGGKLIKNEDREVLLNSTDLATDSI SHLLGDENFVILEFEC" gene 459963..460559 /gene="ARL3" /locus_tag="YPL051W" mRNA 459963..460559 /gene="ARL3" /locus_tag="YPL051W" /product="Arf family GTPase ARL3" CDS 459963..460559 /gene="ARL3" /locus_tag="YPL051W" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:9920936]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:15077114|PMID:15077113]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:9920936]" /experiment="EXISTENCE:mutant phenotype:GO:0006886 intracellular protein transport [PMID:9920936]" /experiment="EXISTENCE:mutant phenotype:GO:0034067 protein localization to Golgi apparatus [PMID:26966233|PMID:12620189]" /experiment="EXISTENCE:mutant phenotype:GO:0034976 response to endoplasmic reticulum stress [PMID:26966233]" /experiment="EXISTENCE:mutant phenotype:GO:0043001 Golgi to plasma membrane protein transport [PMID:16926193]" /note="ARF-like small GTPase of the RAS superfamily; required for recruitment of Arl1p, a GTPase that regulates membrane traffic, to the Golgi apparatus; NatC-catalyzed N-terminal acetylation regulates Golgi membrane association mediated by interaction with membrane receptor, Sys1p; similar to ADP-ribosylation factor and orthologous to mammalian ARFRP1" /codon_start=1 /product="Arf family GTPase ARL3" /protein_id="DAA11379.1" /db_xref="SGD:S000005972" /translation="MFHLVKGLYNNWNKKEQYSILILGLDNAGKTTFLETLKKEYSLA FKALEKIQPTVGQNVATIPVDSKQILKFWDVGGQESLRSMWSEYYSLCHGIIFIVDSS DRERLDECSTTLQSVVMDEEIEGVPILMLANKQDRQDRMEVQDIKEVFNKIAEHISAR DSRVLPISALTGEGVKDAIEWMIVRLERNKKSRPPIYK" gene complement(460779..461966) /gene="MNN9" /locus_tag="YPL050C" mRNA complement(460779..461966) /gene="MNN9" /locus_tag="YPL050C" /product="mannosyltransferase complex subunit MNN9" CDS complement(460779..461966) /gene="MNN9" /locus_tag="YPL050C" /experiment="EXISTENCE:direct assay:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:19249370]" /experiment="EXISTENCE:direct assay:GO:0000136 mannan polymerase complex [PMID:9430634]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:9430634]" /experiment="EXISTENCE:direct assay:GO:0006487 protein N-linked glycosylation [PMID:19249370|PMID:9430634]" /note="Subunit of Golgi mannosyltransferase complex; this complex mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation; this complex also contains Anp1p, Mnn10p, Mnn11p, and Hoc1p" /codon_start=1 /product="mannosyltransferase complex subunit MNN9" /protein_id="DAA11380.1" /db_xref="SGD:S000005971" /translation="MSLSLVSYRLRKNPWVNIFLPVLAIFLIYIIFFQRDQSLLGLNG QSISQHKWAHEKENTFYFPFTKKYKMPKYSYKKKSGWLFNDHVEDIIPEGHIAHYDLN KLHSTSEAAVNKEHILILTPMQTFHQQYWDNLLQLNYPRELIELGFITPRTATGDLAL KKLENAIKKVQTDKKTQRFSKITILRQNSQSFDKLMEKERHALDVQKERRAAMALARN ELLFSTIGPHTSWVLWLDADIIETPPSLIQDMTKHNKAILAANIYQRFYDEEKKQPSI RPYDFNNWQESDTGLEIASQMGDDEIIVEGYAEIATYRPLMAHFYDANGVPGEEMALD GVGGGCTLVKAEVHRDGAMFPNFPFYHLIETEGFAKMAKRLNYDVFGLPNYLVYHIEE ENH" gene complement(462481..463839) /gene="DIG1" /locus_tag="YPL049C" /gene_synonym="RST1" mRNA complement(462481..463839) /gene="DIG1" /locus_tag="YPL049C" /gene_synonym="RST1" /product="Dig1p" CDS complement(462481..463839) /gene="DIG1" /locus_tag="YPL049C" /gene_synonym="RST1" /experiment="EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:10825185]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8918885|PMID:9094309]" /experiment="EXISTENCE:direct assay:GO:1990526 Ste12p-Dig1p-Dig2p complex [PMID:16782869]" /experiment="EXISTENCE:direct assay:GO:1990527 Tec1p-Ste12p-Dig1p complex [PMID:16782869]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9094309|PMID:9860980]" /experiment="EXISTENCE:genetic interaction:GO:0071444 cellular response to pheromone [PMID:9860980|PMID:9094309]" /experiment="EXISTENCE:genetic interaction:GO:2000218 negative regulation of invasive growth in response to glucose limitation [PMID:8918885|PMID:9094309]" /experiment="EXISTENCE:genetic interaction:GO:2000221 negative regulation of pseudohyphal growth [PMID:9094309|PMID:8918885]" /note="MAP kinase-responsive inhibitor of the Ste12p transcription factor; involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p; DIG1 has a paralog, DIG2, that arose from the whole genome duplication" /codon_start=1 /product="Dig1p" /protein_id="DAA11381.1" /db_xref="SGD:S000005970" /translation="MAVSARLRTTAEDTSIAKSTQDPIGDTEISVANAKGSSDSNIKN SPGGNSVGQESELEHVPEEDDSGDKEADHEDSETATAKKRKAQPLKNPKKSLKRGRVP APLNLSDSNTNTHGGNIKDGNLASSNSAHFPPVANQNVKSAPAQVTQHSKFQPRVQYL GKASSRQSIQVNNSSNSYGKPHMPSAGIMSAMNPYMPMNRYIMSPYYNPYGIPPPHML NKPIMTPYVSYPYPMGPRTSIPYAMQGGNARPYEENEYSASNYRNKRVNDSYDSPLSG TASTGKTRRSEEGSRNSSVGSSANAGPTQQRADLRPADMIPAEEYHFERDALLSANTK ARSASTSTSTSTSTNRDRSSWHEAEPNKDEEEGTDLAIEDGAVPTPTFTTFQRTSQPQ QQSPSLLQGEIRLSSHIFAFEFPLSSSNVDKKMFMSICNKVWNESKELTKKSSSHHRT GK" gene 464401..465648 /gene="CAM1" /locus_tag="YPL048W" /gene_synonym="TEF3" mRNA 464401..465648 /gene="CAM1" /locus_tag="YPL048W" /gene_synonym="TEF3" /product="translation elongation factor EF1B gamma" CDS 464401..465648 /gene="CAM1" /locus_tag="YPL048W" /gene_synonym="TEF3" /experiment="EXISTENCE:direct assay:GO:0001046 core promoter sequence-specific DNA binding [PMID:12824466]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:3528160]" /experiment="EXISTENCE:direct assay:GO:0005509 calcium ion binding [PMID:8465602]" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:8465602]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12824466]" /experiment="EXISTENCE:direct assay:GO:0006414 translational elongation [PMID:3528160]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:genetic interaction:GO:0006449 regulation of translational termination [PMID:19545407]" /experiment="EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:12824466]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12824466]" /note="One of two isoforms of the gamma subunit of eEF1B; stimulates the release of GDP from eEF1A (Tef1p/Tef2p) post association with the ribosomal complex with eEF1Balpha subunit; nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids" /codon_start=1 /product="translation elongation factor EF1B gamma" /protein_id="DAA11382.1" /db_xref="SGD:S000005969" /translation="MSQGTLYANFRIRTWVPRGLVKALKLDVKVVTPDAAAEQFARDF PLKKVPAFVGPKGYKLTEAMAINYYLVKLSQDDKMKTQLLGADDDLNAQAQIIRWQSL ANSDLCIQIANTIVPLKGGAPYNKKSVDSAMDAVDKIVDIFENRLKNYTYLATENISL ADLVAASIFTRYFESLFGTEWRAQHPAIVRWFNTVRASPFLKDEYKDFKFADKPLSPP QKKKEKKAPAAAPAASKKKEEAKPAATETETSSKKPKHPLELLGKSTFVLDDWKRKYS NEDTRPVALPWFWEHYNPEEYSLWKVTYKYNDELTLTFMSNNLVGGFFNRLSASTKYM FGCLVVYGENNNNGIVGAVMVRGQDYVPAFDVAPDWESYDYAKLDPTNDDDKEFINNM WAWDKPVSVNGEPKEIVDGKVLK" gene 465962..466261 /gene="SGF11" /locus_tag="YPL047W" mRNA 465962..466261 /gene="SGF11" /locus_tag="YPL047W" /product="SAGA histone acetyltransferase complex subunit SGF11" CDS 465962..466261 /gene="SGF11" /locus_tag="YPL047W" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:15282323]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:18488019]" /experiment="EXISTENCE:direct assay:GO:0071819 DUBm complex [PMID:20395473]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:15282323]" /note="Integral subunit of SAGA histone acetyltransferase complex; regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation" /codon_start=1 /product="SAGA histone acetyltransferase complex subunit SGF11" /protein_id="DAA11383.1" /db_xref="SGD:S000005968" /translation="MTEETITIDSISNGILNNLLTTLIQDIVARETTQQQLLKTRYPD LRSYYFDPNGSLDINGLQKQQESSQYIHCENCGRDVSANRLAAHLQRCLSRGARR" gene complement(466644..466943) /gene="ELC1" /locus_tag="YPL046C" mRNA complement(466644..466943) /gene="ELC1" /locus_tag="YPL046C" /product="elongin C" CDS complement(466644..466943) /gene="ELC1" /locus_tag="YPL046C" /experiment="EXISTENCE:direct assay:GO:0000113 nucleotide-excision repair factor 4 complex [PMID:15226437]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:16675952]" /experiment="EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:16675952]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:16705154]" /experiment="EXISTENCE:mutant phenotype:GO:0031463 Cul3-RING ubiquitin ligase complex [PMID:17296727]" /experiment="EXISTENCE:mutant phenotype:GO:0070911 global genome nucleotide-excision repair [PMID:18817898]" /experiment="EXISTENCE:physical interaction:GO:0031463 Cul3-RING ubiquitin ligase complex [PMID:16675952]" /experiment="EXISTENCE:physical interaction:GO:0070449 elongin complex [PMID:10753924|PMID:10430890]" /note="Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair" /codon_start=1 /product="elongin C" /protein_id="DAA11384.1" /db_xref="SGD:S000005967" /translation="MSQDFVTLVSKDDKEYEISRSAAMISPTLKAMIEGPFRESKGRI ELKQFDSHILEKAVEYLNYNLKYSGVSEDDDEIPEFEIPTEMSLELLLAADYLSI" gene 467260..469656 /gene="VPS16" /locus_tag="YPL045W" /gene_synonym="CVT15" /gene_synonym="SVL6" /gene_synonym="VAM9" /gene_synonym="VPT16" mRNA 467260..469656 /gene="VPS16" /locus_tag="YPL045W" /gene_synonym="CVT15" /gene_synonym="SVL6" /gene_synonym="VAM9" /gene_synonym="VPT16" /product="tethering complex subunit VPS16" CDS 467260..469656 /gene="VPS16" /locus_tag="YPL045W" /gene_synonym="CVT15" /gene_synonym="SVL6" /gene_synonym="VAM9" /gene_synonym="VPT16" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:9362071|PMID:10944212]" /experiment="EXISTENCE:direct assay:GO:0033263 CORVET complex [PMID:17488625]" /experiment="EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:16601699]" /experiment="EXISTENCE:direct assay:GO:0035542 regulation of SNARE complex assembly [PMID:18385512]" /experiment="EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]" /experiment="EXISTENCE:direct assay:GO:0099022 vesicle tethering [PMID:27307091]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:9362071]" /experiment="EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:11422941]" /experiment="EXISTENCE:mutant phenotype:GO:0007033 vacuole organization [PMID:9362071]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:11422941]" /experiment="EXISTENCE:physical interaction:GO:0030897 HOPS complex [PMID:10944212]" /note="Subunit of the HOPS and the CORVET complexes; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages" /codon_start=1 /product="tethering complex subunit VPS16" /protein_id="DAA11385.1" /db_xref="SGD:S000005966" /translation="MKNPSFDWERLKDVFYRSRAIGELKWPTQYEEFKCALSLTVIAV EIQDFIQVYNYFGQLLGKINLQRIHEDIIKFEFDKDEKLILVTKSSIKIVKGWSPLTI ESVPLQDPTIDTIWDYHNGIMLLAKSRDIYKLNGNEWELLYENKDKKYNLLTKNHWSC NDDSIILLDVDHVYQVSTSNGALLKLITDSSWHKVTISSRGFICLYNMKDNKLQIFRD PARILMEHNLDSTPDDICWCGNDTVACSFEDEIKLYGPDGLYVTFWYPFTVTNLRAEV DGLKVITTEKIYFLSRVQPQTSNIFRIGSTEPGAMLVDSFSLLEDHAPKAIEILKNFV LEKGVLDCIAAAIDEFEPKLQKMLLNAASYGKASLQYKSFDASIFVNACNTIKLLNCF RSFGIFLTVEEYRCISLKGVIDRLLKYHRYYECIQICKLANERFLLGYVFTEWAKDKI KGSPDMEDDELLDKIKSRLSVIDMTDTLQMVAVAKVAYLEGRFQLSRNLALLEKNEEA RIEQLYNLDDDSIALKECIKVQNYSLTISLLIALSKKLTNSQLTKLLIIDMFNNPLYL YYMRMDKAYLYDFYRQTDRFIDLAHVLLQQGKEQQSLHSFLPQIKDLYSQVQNSEVVN NTIEQLQRQEKLWIYQESLGKRFAISFTNMTLDQTLSKLIETGQDKQVKEIVKKFKIS EKKLYHLKCKTLVEAKKFDELLQFAQSRKSPIGYMPFYTYLKSRGHMDKASPYVNMIP GLSYQEKKKLYVECRGFRDAIQLAGKEKDIPGLKEIYNIIPPNEPELKALANETMSRI " gene 469939..471996 /gene="NOP4" /locus_tag="YPL043W" /gene_synonym="NOP77" mRNA 469939..471996 /gene="NOP4" /locus_tag="YPL043W" /gene_synonym="NOP77" /product="mRNA-binding ribosome biosynthesis protein NOP4" CDS 469939..471996 /gene="NOP4" /locus_tag="YPL043W" /gene_synonym="NOP77" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:8039505]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:8039505]" /note="Nucleolar protein; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs); human ortholog RBM28 implicated in ANE syndrome" /codon_start=1 /product="mRNA-binding ribosome biosynthesis protein NOP4" /protein_id="DAA11386.1" /db_xref="SGD:S000005964" /translation="MEETIENVEVPSSNVSKQNDDGLDMKTLFVRSIPQDVTDEQLAD FFSNFAPIKHAVVVKDTNKRSRGFGFVSFAVEDDTKEALAKARKTKFNGHILRVDIAK RRDRSKKTSEVVEKSTPESSEKITGQNNEDEDDADGEDSMLKGKPKLIIRNMPWSCRD PVKLKKIFGRYGTVVEATIPRKRDGKLCGFAFVTMKKISNCRIALENTKDLKIDGRKV AVDFAVQKNRWEDYKKAQPEMNDKDDNESGNEDAEENHDDEEDENEEEDRQVDQASKN KESKRKAQNKREDFSVFVRNVPYDATEESLAPHFSKFGSVKYALPVIDKSTGLAKGTA FVAFKDQYTYNECIKNAPAAGSTSLLIGDDVMPEYVYEGRVLSITPTLVREDAGRMAE KNAAKRKEALGKAPGEKDRRNLYLLNEGRVVEGSKMADLLTNTDMEIREKSYKLRVEQ LKKNPSLHLSMTRLAIRNLPRAMNDKALKALARKAVVEFATEVKNKERHPLSKEEIIR STKEKYKFMGPDEIEAQKKKDKKSGVVKQAKVIMEVKGSTAGRSRGYGFVEFRDHKNA LMGLRWLNCHAVTSDEILEGLNDDEKKQVDNDLGKGRRLCVEFAIENSNVVKRRREQL KQARTKRTRPDNEDTGDVGESENKKPKKEEATTPTNPDDKKMGDDIKRIIGFKRKRKH AKK" gene complement(473040..474707) /gene="SSN3" /locus_tag="YPL042C" /gene_synonym="CDK8" /gene_synonym="GIG2" /gene_synonym="NUT7" /gene_synonym="RYE5" /gene_synonym="SRB10" /gene_synonym="SSX7" /gene_synonym="UME5" /gene_synonym="URR1" mRNA complement(473040..474707) /gene="SSN3" /locus_tag="YPL042C" /gene_synonym="CDK8" /gene_synonym="GIG2" /gene_synonym="NUT7" /gene_synonym="RYE5" /gene_synonym="SRB10" /gene_synonym="SSX7" /gene_synonym="UME5" /gene_synonym="URR1" /product="cyclin-dependent serine/threonine protein kinase SSN3" CDS complement(473040..474707) /gene="SSN3" /locus_tag="YPL042C" /gene_synonym="CDK8" /gene_synonym="GIG2" /gene_synonym="NUT7" /gene_synonym="RYE5" /gene_synonym="SRB10" /gene_synonym="SSX7" /gene_synonym="UME5" /gene_synonym="URR1" /EC_number="2.7.11.22" /EC_number="2.7.11.23" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004693 cyclin-dependent protein serine/threonine kinase activity [PMID:11331604]" /experiment="EXISTENCE:direct assay:GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity [PMID:9702190]" /experiment="EXISTENCE:direct assay:GO:0016592 mediator complex [PMID:11383511|PMID:12200444]" /experiment="EXISTENCE:genetic interaction:GO:0060258 negative regulation of filamentous growth [PMID:12520306]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16109375]" /experiment="EXISTENCE:mutant phenotype:GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity [PMID:9702190]" /experiment="EXISTENCE:mutant phenotype:GO:0031648 protein destabilization [PMID:12520306]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15601835]" /experiment="EXISTENCE:mutant phenotype:GO:0060258 negative regulation of filamentous growth [PMID:12520306]" /experiment="EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:17660569]" /experiment="EXISTENCE:physical interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11226276]" /note="Component of the RNA polymerase II mediator complex; cyclin-dependent protein kinase involved in phosphorylation of the mediator component Pgd1p and suppression of transcription activation by RNA polymerase II; involved in glucose repression" /codon_start=1 /product="cyclin-dependent serine/threonine protein kinase SSN3" /protein_id="DAA11387.1" /db_xref="SGD:S000005963" /translation="MYNGKDRAQNSYQPMYQRPMQVQGQQQAQSFVGKKNTIGSVHGK APMLMANNDVFTIGPYRARKDRMRVSVLEKYEVIGYIAAGTYGKVYKAKRQINSGTNS ANGSSLNGTNAKIPQFDSTQPKSSSSMDMQANTNALRRNLLKDEGVTPGRIRTTREDV SPHYNSQKQTLIKKPLTVFYAIKKFKTEKDGVEQLHYTGISQSACREMALCRELHNKH LTTLVEIFLERKCVHMVYEYAEHDLLQIIHFHSHPEKRMIPPRMVRSIMWQLLDGVSY LHQNWVLHRDLKPANIMVTIDGCVKIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPE LLLGARHYTPAVDLWSVGCIFAELIGLQPIFKGEEAKLDSKKTVPFQVNQLQRILEVL GTPDQKIWPYLEKYPEYDQITKFPKYRDNLATWYHSAGGRDKHALSLLYHLLNYDPIK RIDAFNALEHKYFTESDIPVSENVFEGLTYKYPARRIHTNDNDIMNLGSRTKNNTQAS GITAGAAANALGGLGVNRRILAAAAAAAAAVSGNNASDEPSRKKNRR" gene complement(475118..475741) /gene="MRX11" /locus_tag="YPL041C" mRNA complement(475118..475741) /gene="MRX11" /locus_tag="YPL041C" /product="Mrx11p" CDS complement(475118..475741) /gene="MRX11" /locus_tag="YPL041C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]" /note="Protein that associates with mitochondrial ribosome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; involved in maintenance of telomere length" /codon_start=1 /product="Mrx11p" /protein_id="DAA11388.1" /db_xref="SGD:S000005962" /translation="MTVMNLFFRPCQLQMGSGPLELMLKRPTQLTTFMNTRPGGSTQI RFISGNLDPVKRREDRLRKIFSKSRLLTRLNKNPKFSHYFDRLSEAGTVPTLTSFFIL HEVTAILPLFLLWWLLYNLDLSDDFKLPNFLNGLMDSCHTAMEKFVGKRYQECLNKNK LILSGTVAYVTVKLLYPVRIFISIWGAPYFGKWLLLPFQKLKHLIKK" gene complement(475993..479001) /gene="ISM1" /locus_tag="YPL040C" mRNA complement(475993..479001) /gene="ISM1" /locus_tag="YPL040C" /product="isoleucine--tRNA ligase ISM1" CDS complement(475993..479001) /gene="ISM1" /locus_tag="YPL040C" /EC_number="6.1.1.5" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:7607232]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:7607232]" /note="Mitochondrial isoleucyl-tRNA synthetase; null mutant is deficient in respiratory growth; human homolog IARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant" /codon_start=1 /product="isoleucine--tRNA ligase ISM1" /protein_id="DAA11389.1" /db_xref="SGD:S000005961" /translation="MKRSRLVPQHIFSIISKRYLAKHAYQKTLNLPKTKFPNRSNLEI TLRELIPKSSQLVYKEQLRDFFEEFSKLNTTDEKLEFIKEKLFILHDGPPYANGELHL GHALNKILKDIINRYQLSQGKYIFYKPGWDCHGLPIEIKALKDLSAQQIESISPLKIR SMALKHAQKAIKRQRETFQHFAILTDWETPYLTMDKDYEINQLNIFKEMYERGLIKRQ NKPVYWGTETRTALAEGELEYNENHKSIAAYVKFPLEKKSQMDLCKKLGITNNLPIYC LIWTSTPWTLLSNRAICFNQDFSYSLLRLNSELILVETGSIDKLGLTTNSFETIKQFQ GTHLNGLYYQNLLVDDKVGRPLLHGAHVTSGTGTGLVHTAPGHGQDDYLIGIQNGLEI YSPVDHQGRYQLNELPQSVRSIVRDEGDLTKGRQVLDAETAKIILCKLSDLNLLYKSH EYTHSYPYDWRSKKPVIIRATPQWFADLHDVKNLALESISRVKFCPKRGYSRLSSFMK SRNEWCISRQRSWGIPILSFYKKSEPDSVLMNSEILAHAIEKIKQKGINAWFNDKDND MKEWLPEKYHDVAHEYCRSQDTMDVWFDSGSSWSVIKDFYEKSLKLSKLPSPLYQVCL EGSDQHRGWFQSSLLTKVASSNVPVAPYEEVITHGFTLDENGLKMSKSVGNTISPEAI IRGDENLGLPALGVDGLRYLIAQSNFTTDIVAGPTVMKHVGEALKKVRLTFRYLLSNL QKSQDFNLLPIEQLRRVDQYTLYKINELLETTREHYQKYNFSKVLITLQYHLNNELSA FYFDISKDILYSNQISSLARRQVQTTLVHILNAYRAILAPILPVMVQEVWKYIPEGWL QGQEHIDINPMRGKWPFLDSNTEIVTSFENFELKILKQFQEEFKRLSLEEGVTKTTHS HVTIFTKHHLPFSSDELCDILQSSAVDILQMDDNNNSLPTIELGSGINVQILVERSKR HNCPRCWKANSAEEDKLCDRCKEAVDHLMS" gene 479225..480175 /locus_tag="YPL039W" mRNA 479225..480175 /locus_tag="YPL039W" /product="hypothetical protein" CDS 479225..480175 /locus_tag="YPL039W" /note="hypothetical protein; YPL039W is not an essential gene" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11390.1" /db_xref="SGD:S000005960" /translation="MLKEEYNLSGADNMASAELSFKKQKVVLKKFMIAQVTKGIMQRY ASLLVTMPSDDDNAIIGTNHLKTTKFLEIILHRAKSSHLQFKKVCCIVIKFLDCCSKE TNYMKFLKFSLHKLFVAAFILSVPNVVGDDRDRITTRDETYHLYSQITGLPLEEVINC CSIVRPVLIRRSRQQRRQMLSRREQHSYFLRSSFMNSNSSASPFFSTNRSADDLHVHT RAYSLHSHSDGEGQDRRSEHEETHSMGADADTYRQTTFIPDTPNGLHSRSLIECGIEP TQVSDSGEWSGQSNGYVLVTELQEFNKMGKKLVQEAFRIV" gene 480182..480373 /locus_tag="YPL038W-A" mRNA 480182..480373 /locus_tag="YPL038W-A" /product="hypothetical protein" CDS 480182..480373 /locus_tag="YPL038W-A" /note="hypothetical protein; identified by fungal homology and RT-PCR" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11391.1" /db_xref="SGD:S000028588" /translation="MVCRFVHHSRVIFISIYDFLSTKGKKNMYNYTQEKKTKQKNTFT QASIYYENFFESYRTISCL" gene 480535..481068 /gene="MET31" /locus_tag="YPL038W" mRNA 480535..481068 /gene="MET31" /locus_tag="YPL038W" /product="Met31p" CDS 480535..481068 /gene="MET31" /locus_tag="YPL038W" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:9799240]" /experiment="EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:9199298]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9199298]" /experiment="EXISTENCE:direct assay:GO:0031335 regulation of sulfur amino acid metabolic process [PMID:9199298]" /experiment="EXISTENCE:genetic interaction:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:9799240]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9199298]" /experiment="EXISTENCE:genetic interaction:GO:0031335 regulation of sulfur amino acid metabolic process [PMID:9199298]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:22696683]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9199298]" /experiment="EXISTENCE:mutant phenotype:GO:0031335 regulation of sulfur amino acid metabolic process [PMID:9199298]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:22696683]" /experiment="EXISTENCE:physical interaction:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:9799240]" /note="Zinc-finger DNA-binding transcription factor; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; involved in transcriptional regulation of the methionine biosynthetic genes; feedforward loop controlling expression of MET32 and the lack of such a loop for MET31 may account for the differential actions of Met31p and Met32p; MET31 has a paralog, MET32, that arose from the whole genome duplication" /codon_start=1 /product="Met31p" /protein_id="DAA11392.1" /db_xref="SGD:S000005959" /translation="MKLAQDMNVDEIFLKQAAEAIAVISSSPTHTDPIIRELLHRIRQ SSPLSAVIPAPENVLKAGEPENMARGLIRIPETQTKRTGGNNHSKEGAQLYSCAKCQL KFSRSSDLRRHEKVHSLVLPHICSNCGKGFARKDALKRHSNTLTCQRNRKKLSEGSDV DVDELIKDAIKNGTGLL" gene complement(481428..481901) /gene="EGD1" /locus_tag="YPL037C" mRNA complement(481428..481901) /gene="EGD1" /locus_tag="YPL037C" /product="Egd1p" CDS complement(481428..481901) /gene="EGD1" /locus_tag="YPL037C" /experiment="EXISTENCE:direct assay:GO:0005854 nascent polypeptide-associated complex [PMID:10219998]" /experiment="EXISTENCE:genetic interaction:GO:0006613 cotranslational protein targeting to membrane [PMID:10518932]" /experiment="EXISTENCE:mutant phenotype:GO:0000423 mitophagy [PMID:38177147]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:9482879]" /note="Subunit beta1 of the nascent polypeptide-associated complex (NAC); involved in protein targeting to mitochondria; peripheral component of cytoplasmic ribosomes; regulates Atg32p phosphorylation to promote respiration-induced mitophagy; enhances DNA binding of the Gal4p; homolog of human BTF3b; EGD1 has a paralog, BTT1, that arose from the whole genome duplication" /codon_start=1 /product="Egd1p" /protein_id="DAA11393.1" /db_xref="SGD:S000005958" /translation="MPIDQEKLAKLQKLSANNKVGGTRRKLNKKAGSSAGANKDDTKL QSQLAKLHAVTIDNVAEANFFKDDGKVMHFNKVGVQVAAQHNTSVFYGLPQEKNLQDL FPGIISQLGPEAIQALSQLAAQMEKHEAKAPADAEKKDEAIPELVEGQTFDADVE" gene 482843..485686 /gene="PMA2" /locus_tag="YPL036W" mRNA 482843..485686 /gene="PMA2" /locus_tag="YPL036W" /product="H(+)-exporting P2-type ATPase PMA2" CDS 482843..485686 /gene="PMA2" /locus_tag="YPL036W" /EC_number="7.1.2.1" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836|PMID:8396147]" /experiment="EXISTENCE:direct assay:GO:0008553 P-type proton-exporting transporter activity [PMID:8396147]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:1902600 proton transmembrane transport [PMID:8396147]" /note="Plasma membrane H+-ATPase; isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential" /codon_start=1 /product="H(+)-exporting P2-type ATPase PMA2" /protein_id="DAA11394.1" /db_xref="SGD:S000005957" /translation="MSSTEAKQYKEKPSKEYLHASDGDDPANNSAASSSSSSSTSTSA SSSAAAVPRKAAAASAADDSDSDEDIDQLIDELQSNYGEGDESGEEEVRTDGVHAGQR VVPEKDLSTDPAYGLTSDEVARRRKKYGLNQMAEENESLIVKFLMFFVGPIQFVMEAA AILAAGLSDWVDVGVICALLLLNASVGFIQEFQAGSIVDELKKTLANTATVIRDGQLI EIPANEVVPGEILQLESGTIAPADGRIVTEDCFLQIDQSAITGESLAAEKHYGDEVFS SSTVKTGEAFMVVTATGDNTFVGRAAALVGQASGVEGHFTEVLNGIGIILLVLVIATL LLVWTACFYRTVGIVSILRYTLGITIIGVPVGLPAVVTTTMAVGAAYLAKKQAIVQKL SAIESLAGVEILCSDKTGTLTKNKLSLHEPYTVEGVSPDDLMLTACLAASRKKKGLDA IDKAFLKSLIEYPKAKDALTKYKVLEFHPFDPVSKKVTAVVESPEGERIVCVKGAPLF VLKTVEEDHPIPEDVHENYENKVAELASRGFRALGVARKRGEGHWEILGVMPCMDPPR DDTAQTINEARNLGLRIKMLTGDAVGIAKETCRQLGLGTNIYNAERLGLGGGGDMPGS ELADFVENADGFAEVFPQHKYRVVEILQNRGYLVAMTGDGVNDAPSLKKADTGIAVEG ATDAARSAADIVFLAPGLSAIIDALKTSRQIFHRMYSYVVYRIALSLHLEIFLGLWIA ILNNSLDINLIVFIAIFADVATLTIAYDNAPYAPEPVKWNLPRLWGMSIILGIVLAIG SWITLTTMFLPNGGIIQNFGAMNGVMFLQISLTENWLIFVTRAAGPFWSSIPSWQLAG AVFAVDIIATMFTLFGWWSENWTDIVSVVRVWIWSIGIFCVLGGFYYIMSTSQAFDRL MNGKSLKEKKSTRSVEDFMAAMQRVSTQHEKSS" gene 486712..487209 /locus_tag="YPL034W" mRNA 486712..487209 /locus_tag="YPL034W" /product="hypothetical protein" CDS 486712..487209 /locus_tag="YPL034W" /note="hypothetical protein; YPL034W is not essential gene" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11395.1" /db_xref="SGD:S000005955" /translation="MTTRKTVDSRLLEWQTTCKHPVINLTPEKVDKLYHLKLKSESKN ISSNRLLPISLSSLQKKMEKLFIKDKSHSHKPSLPDPKVPTLRTYKDGGFFISGKGSM KLPDIESAIHKFLWKKYGKGLVYCYGCDPTGKKRHTEWFNVPVLELPSVLRLIDSYCL GGESR" gene complement(487362..488207) /gene="SRL4" /locus_tag="YPL033C" mRNA complement(487362..488207) /gene="SRL4" /locus_tag="YPL033C" /product="Srl4p" CDS complement(487362..488207) /gene="SRL4" /locus_tag="YPL033C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24390141]" /experiment="EXISTENCE:mutant phenotype:GO:0009200 deoxyribonucleoside triphosphate metabolic process [PMID:18337697]" /note="hypothetical protein; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p" /codon_start=1 /product="Srl4p" /protein_id="DAA11396.1" /db_xref="SGD:S000005954" /translation="MKKTIYKVLVSFYQYVGLGKKFHPSHDTVLIIGGSSNELGIELC ETFIEDYHTKVINIDTIDSINGKNARRSEKLYTFISCKDFSDIKCLEESMLYLQNLEI IPTVLINNMQEGIESTLLKEDKFLRLDEESLNEFEKIVRYNLQSVILITKFCLSNIFP KVQAEAQEKAKGFYIVNISSVLTLKPCKSGTHFITSKCGINSFHDGITSELKLKDSNL NVKTLIAYLPSFESEAHWKRLSPSISKHLVHCLLEGRYGDTILESKRSIGDILLITGF KSSFT" gene complement(488887..491364) /gene="SVL3" /locus_tag="YPL032C" mRNA complement(488887..491364) /gene="SVL3" /locus_tag="YPL032C" /product="Svl3p" CDS complement(488887..491364) /gene="SVL3" /locus_tag="YPL032C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:32491201|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:32491201|PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:9751732]" /note="hypothetical protein; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress; SVL3 has a paralog, PAM1, that arose from the whole genome duplication" /codon_start=1 /product="Svl3p" /protein_id="DAA11397.1" /db_xref="SGD:S000005953" /translation="MSSSSLRVLAIGNNPNILFYTSRFQLAKNIDLYHVNDSKSCQFE IETEYYGKDRFELENHFTSIEHLTEALSSKSSEAVFDIIIMSAPSLQELSSLASKLTS IIDSNTKIFLESSGFIQLEPFVKLSMESPHVNVFSILTDLDIRQIGPNHFKHFPSTAK ENTIYLGESKSSTEKYSSGVITLLTTFEKLFAKLFSNIKINLCNFSSIEFLSQQWKLA ISRICFDPLLIMFEQENPSDLDQQIIAKPLISGLVTEIITVAKTMGARLNSSHDNENS LLSLWKNSYHSTNKPPALVYHFIHQTTPLNIDILLLQTILLADDFGIKTPYLEFLYSV LSQFERLNSGKSKWFIRSDEKTQILQSLQKSQKNESALQTQITSLQGQISKLRQELLM QAKQHEMETNELKEKHQVALKAQAQAQAQAQSQAQTSIEALTPTEATNQSDTNEYKAT GTPNLRDIEDMALYSVNYGDSPVRSPPPVVSSQPQMNSPLSSHSQTFGENNGTNDKLL QERELQLRKKELELQERELEFQKRALQQQRFNNSNNSIPRKPSFPQLQQSANVRSNSR GMHGTNGAMSQPASAGNFVDPISSSIAAYDPQQPPSLPLQQPQQSVQVQPFHSHSIKP TSRKNRNSNMPNIGNPSSINMSDFGRPPNNSSQTRLNSMPTHSIVNQNRLRSQQSKNK LNMPHATNPNNTFNQVPAPSLNNHVPTQRQFSSSTMIEVTNNNNKVNNSSSNPDISTN SVVHNAMQFTNTNNNTSSTVDINDPKNIAPPPTTSVSAPSTPTLSSSSQMANMASPST DNGDNEEKNGGKKKRFGLFKKKNKSKK" gene complement(492018..493037) /gene="PHO85" /locus_tag="YPL031C" /gene_synonym="LDB15" mRNA complement(join(492018..492918,493021..493037)) /gene="PHO85" /locus_tag="YPL031C" /gene_synonym="LDB15" /product="cyclin-dependent serine/threonine-protein kinase PHO85" CDS complement(join(492018..492918,493021..493037)) /gene="PHO85" /locus_tag="YPL031C" /gene_synonym="LDB15" /EC_number="2.7.11.22" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004693 cyclin-dependent protein serine/threonine kinase activity [PMID:7973731|PMID:38233717|PMID:19823668|PMID:12407105|PM ID:8108735|PMID:9584169|PMID:7973730]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9853758]" /experiment="EXISTENCE:direct assay:GO:0019216 regulation of lipid metabolic process [PMID:31678512]" /experiment="EXISTENCE:direct assay:GO:0032880 regulation of protein localization [PMID:8539622]" /experiment="EXISTENCE:direct assay:GO:0046822 regulation of nucleocytoplasmic transport [PMID:31422915]" /experiment="EXISTENCE:direct assay:GO:0055088 lipid homeostasis [PMID:31678512]" /experiment="EXISTENCE:direct assay:GO:0071073 positive regulation of phospholipid biosynthetic process [PMID:27743455]" /experiment="EXISTENCE:direct assay:GO:1901987 regulation of cell cycle phase transition [PMID:29146254]" /experiment="EXISTENCE:direct assay:GO:1990860 Pho85-Pho80 CDK-cyclin complex [PMID:8108735]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:19823668|PMID:15738404]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:3915785]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19823668|PMID:15738404]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:16964260]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:12077337]" /experiment="EXISTENCE:genetic interaction:GO:0031647 regulation of protein stability [PMID:16611745]" /experiment="EXISTENCE:genetic interaction:GO:0032878 regulation of establishment or maintenance of cell polarity [PMID:17853895]" /experiment="EXISTENCE:genetic interaction:GO:0045936 negative regulation of phosphate metabolic process [PMID:3915785]" /experiment="EXISTENCE:genetic interaction:GO:0050849 negative regulation of calcium-mediated signaling [PMID:16455487]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:19823668]" /experiment="EXISTENCE:mutant phenotype:GO:0004693 cyclin-dependent protein serine/threonine kinase activity [PMID:9593297|PMID:38233717]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19823668]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:16964260]" /experiment="EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:20417603]" /experiment="EXISTENCE:mutant phenotype:GO:0016242 negative regulation of macroautophagy [PMID:20417603]" /experiment="EXISTENCE:mutant phenotype:GO:0031647 regulation of protein stability [PMID:16508019]" /experiment="EXISTENCE:mutant phenotype:GO:0031648 protein destabilization [PMID:38233717]" /experiment="EXISTENCE:mutant phenotype:GO:0045719 negative regulation of glycogen biosynthetic process [PMID:9584169]" /experiment="EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:9584169|PMID:16611745|PMID:7973730|PMID:8108735|PMID :7973731]" /note="Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels, environmental conditions and progression through the cell cycle; involved in the hyperphosphorylation of Srl3p (Whi7p), regulating protein stability, mRNA levels and promotion of START; human lissencephaly-associated homolog CDK5 functionally complements null mutation" /codon_start=1 /product="cyclin-dependent serine/threonine-protein kinase PHO85" /protein_id="DAA11398.1" /db_xref="SGD:S000005952" /translation="MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEE GTPSTAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTP RGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGI PVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQL KLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHG LLQLNPDMRLSAKQALHHPWFAEYYHHAS" gene 493543..495246 /gene="TRM44" /locus_tag="YPL030W" mRNA 493543..495246 /gene="TRM44" /locus_tag="YPL030W" /product="tRNA (uracil) methyltransferase" CDS 493543..495246 /gene="TRM44" /locus_tag="YPL030W" /EC_number="2.1.1.211" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016300 tRNA (uridine) methyltransferase activity [PMID:18025252]" /experiment="EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:18025252]" /experiment="EXISTENCE:mutant phenotype:GO:0002128 tRNA nucleoside ribose methylation [PMID:32053677]" /experiment="EXISTENCE:mutant phenotype:GO:0016300 tRNA (uridine) methyltransferase activity [PMID:18025252]" /experiment="EXISTENCE:mutant phenotype:GO:0030488 tRNA methylation [PMID:18025252]" /note="tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene" /codon_start=1 /product="tRNA (uracil) methyltransferase" /protein_id="DAA11399.1" /db_xref="SGD:S000005951" /translation="MTGDGSAHISKNNQNQHKDRFKFIVNDKSILGPQWLSLYQTDGK VTFAKSHFEQAMMNVIREPNINSTVILRADILKEINHAAEAGSEPKFDESVLKKFEID NGNESGEEDVKKINIEDLNIRSCETSESLKLSPVHEFVRRIIPRNFYKDAIINQTCLI LNSKDPNFQETSLIVYTPHINSEKDCPFYIPRTQSVGILLHQSVLSVHYIPFPEDKTA FTDESERVVRTAYRLLQTANKHSKGVMQGYEKRVNHDQVVNKVNFQNTYIVLKKKYSK FLVENWAESTDPKKHVFEDIAIAAFLIELWIKVYGPDFRSKMQFRDLGCGNGALCYIL LSESIKGLGIDARKRKSWSIYPPEVQSSLKEQVIIPSILLRPHPALKRQVPHLEHNGR FFPVKVTHEVIAPATVVYSSEDLLKSPQVNTAEFPPDTFIIGNHSDELTCWIPLLGHP YMVIPCCSHNFSGQRVRFNVRKRSPRSNEIKNQNNSKSTYSGLVDHVEYISSRVGWKV EKEMLRIPSTRNAAIIGVENATLKHFPTQAVYDMIWEDGGAEGWIQNTMSLLKRNPRN H" gene 495506..497719 /gene="SUV3" /locus_tag="YPL029W" /gene_synonym="LPB2" mRNA 495506..497719 /gene="SUV3" /locus_tag="YPL029W" /gene_synonym="LPB2" /product="ATP-dependent RNA helicase SUV3" CDS 495506..497719 /gene="SUV3" /locus_tag="YPL029W" /gene_synonym="LPB2" /EC_number="3.6.4.13" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:12426313|PMID:17658549]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0008859 exoribonuclease II activity [PMID:17658549]" /experiment="EXISTENCE:direct assay:GO:0045025 mitochondrial degradosome [PMID:12426313]" /experiment="EXISTENCE:genetic interaction:GO:0000372 Group I intron splicing [PMID:20064926]" /experiment="EXISTENCE:mutant phenotype:GO:0000957 mitochondrial RNA catabolic process [PMID:12426313]" /experiment="EXISTENCE:mutant phenotype:GO:0006264 mitochondrial DNA replication [PMID:21911497]" /note="ATP-dependent RNA helicase; component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron; expression of a processed form of human homolog SUPV3L1 carrying an N-terminal deletion of 46 amino acids rescues yeast suv3 null mutant" /codon_start=1 /product="ATP-dependent RNA helicase SUV3" /protein_id="DAA11400.1" /db_xref="SGD:S000005950" /translation="MALVKYSTVFFPLRSLRLFVSIKKAYYHSEPHSIDLFHDKDWIV KRPKFLNLPKNEHSKLDIFQFNFNKSESNNVYLQDSSFKDNLDKAMQFIYNDKLSSLD AKQVPIKNLAWLKLRDYIYQQLKDPKLQAKTYVPSVSEIIHPSSPGNLISLLINCNKI SNLVWKSVLKYSLSNNITTLDKFIHVLQQTFDHVYEQEILPMMTNTDDTDGAHNVDIT NPAEWFPEARKIRRHIIMHIGPTNSGKTYRALQKLKSVDRGYYAGPLRLLAREVYDRF HAEKIRCNLLTGEEVIRDLDDRGNSAGLTSGTVEMVPINQKFDVVVLDEIQMMSDGDR GWAWTNALLGVVSKEVHLCGEKSVLPLVKSIVKMTGDKLTINEYERLGKLSVEEKPIK DGIKGLRKGDCVVAFSKKKILDLKLKIEKDTNLKVAVIYGSLPPETRVQQAALFNNGE YDIMVASDAIGMGLNLSIDRVVFTTNMKYNGEELMEMTSSQIKQIGGRAGRFKSRSAS GGVPQGFITSFESKVLKSVRKAIEAPVEYLKTAVTWPTDEICAQLMTQFPPGTPTSVL LQTISDELEKSSDNLFTLSDLKSKLKVIGLFEHMEDIPFFDKLKLSNAPVKDMPMVTK AFTKFCETIAKRHTRGLLSYRLPFNLLDYNCIPNESYSLEVYESLYNIITLYFWLSNR YPNYFIDMESAKDLKYFCEMIIFEKLDRLKKNPYAHKPFGSTRGHLSSSRRRLRT" gene 498096..499292 /gene="ERG10" /locus_tag="YPL028W" /gene_synonym="LPB3" /gene_synonym="TSM0115" mRNA 498096..499292 /gene="ERG10" /locus_tag="YPL028W" /gene_synonym="LPB3" /gene_synonym="TSM0115" /product="acetyl-CoA C-acetyltransferase" CDS 498096..499292 /gene="ERG10" /locus_tag="YPL028W" /gene_synonym="LPB3" /gene_synonym="TSM0115" /EC_number="2.3.1.9" /experiment="EXISTENCE:direct assay:GO:0003985 acetyl-CoA C-acetyltransferase activity [PMID:5571829|PMID:7989303]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:5571830]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:5571829]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:200835]" /note="Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase); cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis; human ACAT1 functionally complements the growth defect caused by repression of ERG10 expression" /codon_start=1 /product="acetyl-CoA C-acetyltransferase" /protein_id="DAA11401.1" /db_xref="SGD:S000005949" /translation="MSQNVYIVSTARTPIGSFQGSLSSKTAVELGAVALKGALAKVPE LDASKDFDEIIFGNVLSANLGQAPARQVALAAGLSNHIVASTVNKVCASAMKAIILGA QSIKCGNADVVVAGGCESMTNAPYYMPAARAGAKFGQTVLVDGVERDGLNDAYDGLAM GVHAEKCARDWDITREQQDNFAIESYQKSQKSQKEGKFDNEIVPVTIKGFRGKPDTQV TKDEEPARLHVEKLRSARTVFQKENGTVTAANASPINDGAAAVILVSEKVLKEKNLKP LAIIKGWGEAAHQPADFTWAPSLAVPKALKHAGIEDINSVDYFEFNEAFSVVGLVNTK ILKLDPSKVNVYGGAVALGHPLGCSGARVVVTLLSILQQEGGKIGVAAICNGGGGASS IVIEKI" gene 499665..500402 /gene="SMA1" /locus_tag="YPL027W" mRNA 499665..500402 /gene="SMA1" /locus_tag="YPL027W" /product="Sma1p" CDS 499665..500402 /gene="SMA1" /locus_tag="YPL027W" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141|PMID:16148007]" /experiment="EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:16148007|PMID:11470404]" /note="hypothetical protein involved in prospore membrane assembly; involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p" /codon_start=1 /product="Sma1p" /protein_id="DAA11402.1" /db_xref="SGD:S000005948" /translation="MACTNDGPNKYPEIVSVKHLFQHSGSKHEFSAGKRFSKSIGKIF KRNSALKTSRTETANHKMELKKREGVTLLPPVPESLLHKLNSWLETFSSTKNMKIEEN KIVINEKEIRDSVSYYPDKNGGSAVFCYLPDLVLYYKPPIKVTGKQCPIKRSPWESME IQYQKFMYPLERLERQFEEVPFRPWYFAMRLKELYRCCERSFTNAANRGKARLLRGKQ RTKKSYHKTVNLVSAKISTHSNAPSPG" gene complement(500675..502183) /gene="SKS1" /locus_tag="YPL026C" /gene_synonym="SHA3" mRNA complement(500675..502183) /gene="SKS1" /locus_tag="YPL026C" /gene_synonym="SHA3" /product="putative serine/threonine protein kinase SKS1" CDS complement(500675..502183) /gene="SKS1" /locus_tag="YPL026C" /gene_synonym="SHA3" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18417610]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0010827 regulation of D-glucose transmembrane transport [PMID:8948096]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8948096]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:24603354]" /note="Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway; SKS1 has a paralog, VHS1, that arose from the whole genome duplication" /codon_start=1 /product="putative serine/threonine protein kinase SKS1" /protein_id="DAA11403.1" /db_xref="SGD:S000005947" /translation="MLSDCLLNNFRITAQIGSGAYGLVFHVVDILTSREYAVKTVFKS SSMDEFYNKNGLNNNSQVARTTLLQTQLYHFFKSFQKKLFLPSVDLDSILQLTENELN RLPHYREIAFQLRVQSHGNIVKIHQVLESSIATFIVMDYYDRDLFTSIVDDKHFVNHG ILIKKVFLQLCSALDHCHRLGIYHCDIKPENVLLDRNDNAYLCDFGLSTKSKYLAPNV CVGSSYYMAPERILYCLNTTTNGIHVDECCSSLPTDTGDIWSLGIILINLTCIRNPWL KAHQKEDNTFQHFANDNNVLKKILPISDELFTVLTKILQLNPYTRIDMKTLMSEVSSL TSFTREGPLSQVPILSSEVYMTHIIRNENLFLSDLSHFSADQEQQQQQQQQQQQVQEQ EQEQKQEQIQNQEQAQQQQEEEDAEPESDIPSTYNSDGSMEKYEYTNNHNNSTFLTSS MDSTPYQSDIDDVSASKDCKFQQDTLRNRLLCLQMNFSTLTDGPNEKWLPDY" gene 503517..504242 /gene="RMI1" /locus_tag="YPL024W" /gene_synonym="NCE4" mRNA 503517..504242 /gene="RMI1" /locus_tag="YPL024W" /gene_synonym="NCE4" /product="Rmi1p" CDS 503517..504242 /gene="RMI1" /locus_tag="YPL024W" /gene_synonym="NCE4" /experiment="EXISTENCE:direct assay:GO:0000400 four-way junction DNA binding [PMID:15899853]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:15899853]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:22885009]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:17693398]" /experiment="EXISTENCE:direct assay:GO:0031422 RecQ family helicase-topoisomerase III complex [PMID:15899853]" /experiment="EXISTENCE:direct assay:GO:0043388 positive regulation of DNA binding [PMID:17693398]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:23036200]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:15889139]" /experiment="EXISTENCE:physical interaction:GO:0031422 RecQ family helicase-topoisomerase III complex [PMID:15889139]" /note="Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing, DNA catenation/decatenation and ssDNA binding activities of Top3p; involved in response to DNA damage; functions in S phase-mediated cohesion establishment via a pathway involving the Ctf18-RFC complex and Mrc1p; stimulates Top3p DNA catenation/decatenation activity; null mutants display increased rates of recombination and delayed S phase" /codon_start=1 /product="Rmi1p" /protein_id="DAA11404.1" /db_xref="SGD:S000005945" /translation="MSFSSILSQDITDDITPPAYSATLGSREQIVFRAYQNEPWLAGT ASNLILDKKLVIVDRELLFQVLMVENITKSKLTQIDDIKTKLDPKKQKVDRLRSGAQG NGAKKYEVITQVDMEDDGNVADNNCAKENNSNNNSSAAKNKAVFKLTLQSKSGDVFFA INSTPISWSSCMLGSKIVILPGTVFNRGVFILKDSQVIFLGGINRVWNENRDQKFCDY LESKLQRDKQLVNGGSKKRKAND" gene complement(504339..506312) /gene="MET12" /locus_tag="YPL023C" mRNA complement(504339..506312) /gene="MET12" /locus_tag="YPL023C" /product="methylenetetrahydrofolate reductase (NAD(P)H) MET12" CDS complement(504339..506312) /gene="MET12" /locus_tag="YPL023C" /EC_number="1.5.1.20" /experiment="EXISTENCE:direct assay:GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity [PMID:10600168]" /experiment="EXISTENCE:direct assay:GO:0035999 tetrahydrofolate interconversion [PMID:10600168]" /note="Protein with MTHFR activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of methylenetetrahydrofolate reductase (MTHFR)" /codon_start=1 /product="methylenetetrahydrofolate reductase (NAD(P)H) MET12" /protein_id="DAA11405.1" /db_xref="SGD:S000005944" /translation="MSIRDLYHARASPFISLEFFPPKTELGTRNLMERMHRMTALDPL FITVTWGAGGTTAEKTLTLASLAQQTLNIPVCMHLTCTNTEKAIIDDALDRCYNAGIR NILALRGDPPIGEDWLDSQSNESPFKYAVDLVRYIKQSYGDKFCVGVAAYPEGHCEGE AEGHEQDPLKDLVYLKEKVEAGADFVITQLFYDVEKFLTFEMLFRERISQDLPLFPGL MPINSYLLFHRAAKLSHASIPPAILSRFPPEIQSDDNAVKSIGVDILIELIQEIYQRT SGRIKGFHFYTLNLEKAIAQIVSQSPVLSHIVNESSEEEGEDETSGEIGSIENVPIED ADGDIVLDDSNEETVANRKRRRHSSLDSAKLIFNRAIVTEKGLRYNNENGSMPSKKAL ISISKGHGTLGRDATWDEFPNGRFGDSRSPAYGEIDGYGPSIKVSKSKALELWGIPKT IGDLKDIFIKYLEGSTDAIPWSDLGLSAETALIQEELIQLNYRGYLTLASQPATNATL SSDKIFGWGPAKGRLYQKAFVEMFIHRQQWETTLKPKLDHYGRRKFSYYAGDSSGSFE TNLDPHSSSVVTWGVFPNSPVKQTTIIEEESFKAWRDEAFSIWSEWAKLFPRNTPANI LLRLVHKDYCLVSIVHHDFKETDELWEMLLDQA" gene 506697..509999 /gene="RAD1" /locus_tag="YPL022W" /gene_synonym="LPB9" /gene_synonym="RAD12" mRNA 506697..509999 /gene="RAD1" /locus_tag="YPL022W" /gene_synonym="LPB9" /gene_synonym="RAD12" /product="ssDNA endodeoxyribonuclease RAD1" CDS 506697..509999 /gene="RAD1" /locus_tag="YPL022W" /gene_synonym="LPB9" /gene_synonym="RAD12" /experiment="EXISTENCE:direct assay:GO:0000014 single-stranded DNA endodeoxyribonuclease activity [PMID:8253764]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:8253764]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9852079]" /experiment="EXISTENCE:direct assay:GO:0006289 nucleotide-excision repair [PMID:7559571]" /experiment="EXISTENCE:mutant phenotype:GO:0000710 meiotic mismatch repair [PMID:11514439]" /experiment="EXISTENCE:mutant phenotype:GO:0000735 removal of nonhomologous ends [PMID:1411547|PMID:7891718]" /experiment="EXISTENCE:mutant phenotype:GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends [PMID:1411547|PMID:7891718]" /experiment="EXISTENCE:mutant phenotype:GO:0006277 DNA amplification [PMID:23271978]" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:3065620]" /experiment="EXISTENCE:physical interaction:GO:0000110 nucleotide-excision repair factor 1 complex [PMID:8621533]" /note="Single-stranded DNA endonuclease (with Rad10p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein" /codon_start=1 /product="ssDNA endodeoxyribonuclease RAD1" /protein_id="DAA11406.1" /db_xref="SGD:S000005943" /translation="MSQLFYQGDSDDELQEELTRQTTQASQSSKIKNEDEPDDSNHLN EVENEDSKVLDDDAVLYPLIPNEPDDIETSKPNINDIRPVDIQLTLPLPFQQKVVENS LITEDALIIMGKGLGLLDIVANLLHVLATPTSINGQLKRALVLVLNAKPIDNVRIKEA LEELSWFSNTGKDDDDTAVESDDELFERPFNVVTADSLSIEKRRKLYISGGILSITSR ILIVDLLSGIVHPNRVTGMLVLNADSLRHNSNESFILEIYRSKNTWGFIKAFSEAPET FVMEFSPLRTKMKELRLKNVLLWPRFRVEVSSCLNATNKTSHNKVIEVKVSLTNSMSQ IQFGLMECLKKCIAELSRKNPELALDWWNMENVLDINFIRSIDSVMVPNWHRISYESK QLVKDIRFLRHLLKMLVTSDAVDFFGEIQLSLDANKPSVSRKYSESPWLLVDEAQLVI SYAKKRIFYKNEYTLEENPKWEQLIHILHDISHERMTNHLQGPTLVACSDNLTCLELA KVLNASNKKRGVRQVLLNKLKWYRKQREETKKLVKEVQSQDTFPENATLNVSSTFSKE QVTTKRRRTRGASQVAAVEKLRNAGTNVDMEVVFEDHKLSEEIKKGSGDDLDDGQEEN AANDSKIFEIQEQENEILIDDGDAEFDNGELEYVGDLPQHITTHFNKDLWAEHCNEYE YVDRQDEILISTFKSLNDNCSLQEMMPSYIIMFEPDISFIRQIEVYKAIVKDLQPKVY FMYYGESIEEQSHLTAIKREKDAFTKLIRENANLSHHFETNEDLSHYKNLAERKLKLS KLRKSNTRNAGGQQGFHNLTQDVVIVDTREFNASLPGLLYRYGIRVIPCMLTVGDYVI TPDICLERKSISDLIGSLQNNRLANQCKKMLKYYAYPTLLIEFDEGQSFSLEPFSERR NYKNKDISTVHPISSKLSQDEIQLKLAKLVLRFPTLKIIWSSSPLQTVNIILELKLGR EQPDPSNAVILGTNKVRSDFNSTAKGLKDGDNESKFKRLLNVPGVSKIDYFNLRKKIK SFNKLQKLSWNEINELINDEDLTDRIYYFLRTEKEEQEQESTDENLESPGKTTDDNAL HDHHNDVPEAPV" gene 511101..511664 /gene="ECM23" /locus_tag="YPL021W" /gene_synonym="SRD2" mRNA 511101..511664 /gene="ECM23" /locus_tag="YPL021W" /gene_synonym="SRD2" /product="Ecm23p" CDS 511101..511664 /gene="ECM23" /locus_tag="YPL021W" /gene_synonym="SRD2" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:11889490]" /note="Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p" /codon_start=1 /product="Ecm23p" /protein_id="DAA11407.1" /db_xref="SGD:S000005942" /translation="MLYNKEQGTSGASSSGRRTKFHFDRFVQMVLFIAANPNYCCSVA SIPKSGVTPDLKRADILEQKIKSLNSALSPKLKEESRLGGPLHNPSILPAPSFSSLPI SSNGKKSLAGYRPKSRKKQTILPNGQPKECATCGDTWTSQWRSGPNGNVELCSRCGIA YRKKMEKKIRSQQSSDDGTKNFIFKNK" rep_origin 511636..511793 /note="ARS1621; Autonomously Replicating Sequence" /db_xref="SGD:S000118417" gene complement(512313..514178) /gene="ULP1" /locus_tag="YPL020C" /gene_synonym="NIB1" mRNA complement(512313..514178) /gene="ULP1" /locus_tag="YPL020C" /gene_synonym="NIB1" /product="SUMO protease ULP1" CDS complement(512313..514178) /gene="ULP1" /locus_tag="YPL020C" /gene_synonym="NIB1" /EC_number="3.4.22.68" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:20647537|PMID:10713161]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:20647537]" /experiment="EXISTENCE:direct assay:GO:0008234 cysteine-type peptidase activity [PMID:10094048]" /experiment="EXISTENCE:direct assay:GO:0016926 protein desumoylation [PMID:10094048]" /experiment="EXISTENCE:direct assay:GO:0016929 deSUMOylase activity [PMID:10094048]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:10094048]" /experiment="EXISTENCE:mutant phenotype:GO:0016926 protein desumoylation [PMID:10094048]" /experiment="EXISTENCE:mutant phenotype:GO:0016929 deSUMOylase activity [PMID:10094048]" /note="Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; contributes to regulation of telomeric silencing; sequestered to the nucleolus under stress conditions" /codon_start=1 /product="SUMO protease ULP1" /protein_id="DAA11408.1" /db_xref="SGD:S000005941" /translation="MSVEVDKHRNTLQYHKKNPYSPLFSPISTYRCYPRVLNNPSESR RSASFSGIYKKRTNTSRFNYLNDRRVLSMEESMKDGSDRASKAGFIGGIRETLWNSGK YLWHTFVKNEPRNFDGSEVEASGNSDVESRSSGSRSSDVPYGLRENYSSDTRKHKFDT STWALPNKRRRIESEGVGTPSTSPISSLASQKSNCDSDNSITFSRDPFGWNKWKTSAI GSNSENNTSDQKNSYDRRQYGTAFIRKKKVAKQNINNTKLVSRAQSEEVTYLRQIFNG EYKVPKILKEERERQLKLMDMDKEKDTGLKKSIIDLTEKIKTILIENNKNRLQTRNEN DDDLVFVKEKKISSLERKHKDYLNQKLKFDRSILEFEKDFKRYNEILNERKKIQEDLK KKKEQLAKKKLVPELNEKDDDQVQKALASRENTQLMNRDNIEITVRDFKTLAPRRWLN DTIIEFFMKYIEKSTPNTVAFNSFFYTNLSERGYQGVRRWMKRKKTQIDKLDKIFTPI NLNQSHWALGIIDLKKKTIGYVDSLSNGPNAMSFAILTDLQKYVMEESKHTIGEDFDL IHLDCPQQPNGYDCGIYVCMNTLYGSADAPLDFDYKDAIRMRRFIAHLILTDALK" gene complement(514511..517018) /gene="VTC3" /locus_tag="YPL019C" /gene_synonym="PHM2" mRNA complement(514511..517018) /gene="VTC3" /locus_tag="YPL019C" /gene_synonym="PHM2" /product="vacuolar transporter chaperone" CDS complement(514511..517018) /gene="VTC3" /locus_tag="YPL019C" /gene_synonym="PHM2" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:11823419|PMID:11102525]" /experiment="EXISTENCE:direct assay:GO:0005516 calmodulin binding [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0007034 vacuolar transport [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0016237 microautophagy [PMID:17079729]" /experiment="EXISTENCE:genetic interaction:GO:0006797 polyphosphate metabolic process [PMID:11102525]" /experiment="EXISTENCE:mutant phenotype:GO:0006797 polyphosphate metabolic process [PMID:11102525]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:17079729]" /experiment="EXISTENCE:mutant phenotype:GO:0016237 microautophagy [PMID:17079729]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:11823419]" /experiment="EXISTENCE:physical interaction:GO:0033254 vacuolar transporter chaperone complex [PMID:11823419]" /note="Regulatory subunit of vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; important regulator of substrate invagination from the vacuolar membrane; targeted to vacuole via AP-3 pathway; VTC3 has a paralog, VTC2, that arose from the whole genome duplication" /codon_start=1 /product="vacuolar transporter chaperone" /protein_id="DAA11409.1" /db_xref="SGD:S000005940" /translation="MLFGIKLANDVYPPWKDSYIDYERLKKLLKESVIHDGRSSVDSW SERNESDFVEALDKELEKVYTFQISKYNAVLRKLDDLEENTKSAEKIQKINSEQFKNT LEECLDEAQRLDNFDRLNFTGFIKIVKKHDKLHPNYPSVKSLLQVRLKELPFNNSEEY SPLLYRISYLYEFLRSNYDHPNTVSKSLASTSKLSHFSNLEDASFKSYKFWVHDDNIM EVKARILRHLPALVYASVPNENDDFVDNLESDVRVQPEARLNIGSKSNSLSSDGNSNQ DVEIGKSKSVIFPQSYDPTITTLYFDNDFFDLYNNRLLKISGAPTLRLRWIGKLLDKP DIFLEKRTFTENTETGNSSFEEIRLQMKAKFINNFIFKNDPSYKNYLINQLRERGTQK EELEKLSRDFDNIQNFIVEEKLQPVLRATYNRTAFQIPGDQSIRVTIDSNIMYIREDS LDKNRPIRNPENWHRDDIDSNIPNPLRFLRAGEYSKFPYSVMEIKVINQDNSQMPNYE WIKDLTNSHLVNEVPKFSLYLQGVASLFGEDDKYVNILPFWLPDLETDIRKNPQEAYE EEKKTLQKQKSIHDKLDNMRRLSKISVPDGKTTERQGQKDQNTRHVIADLEDHESSDE EGTALPKKSAVKKGKKFKTNAAFLKILAGKNISENGNDPYSDDTDSASSFQLPPGVKK PVHLLKNAGPVKVEAKVWLANERTFNRWLSVTTLLSVLTFSIYNSVQKAEFPQLADLL AYVYFFLTLFCGVWAYRTYLKRLTLIKGRSGKHLDAPVGPILVAVVLIVTLVVNFSVA FKEAARRERGLVNVSSQPSLPRTLKPIQDFIFNLVGE" gene 517651..518760 /gene="CTF19" /locus_tag="YPL018W" /gene_synonym="MCM18" mRNA 517651..518760 /gene="CTF19" /locus_tag="YPL018W" /gene_synonym="MCM18" /product="Ctf19p" CDS 517651..518760 /gene="CTF19" /locus_tag="YPL018W" /gene_synonym="MCM18" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:10189365]" /experiment="EXISTENCE:direct assay:GO:0000817 COMA complex [PMID:14633972]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10189365]" /experiment="EXISTENCE:direct assay:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:10189365]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:10189365]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:22426531]" /experiment="EXISTENCE:mutant phenotype:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:10189365]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:19730685]" /experiment="EXISTENCE:mutant phenotype:GO:0071459 protein localization to chromosome, centromeric region [PMID:26653857]" /note="Outer kinetochore protein, needed for accurate chromosome segregation; component of kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as platform for kinetochore assembly; required for spindle assembly checkpoint; minimizes potentially deleterious centromere-proximal crossovers by preventing meiotic DNA break formation proximal to centromere; homolog of human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2" /codon_start=1 /product="Ctf19p" /protein_id="DAA11410.1" /db_xref="SGD:S000005939" /translation="MDFTSDTTNSHDTSNSHLSLEDAVGTHHAGEADVNIDGDEKQQL SLLDDDQVRALKLQEEKDALLTRRNTLLQEIQTYQNILMKENNSKTKNGDILQNDITQ DFLNLISISSSNPNSAISDRKRVERINGLTNLQKELVTKYDTLPLLNMNLRLSYLRDH TYPHLQVSVQSRDRVHNDGIEVLVVNYKFCRNTMNPFEIQFKMFYKFEDSTLLKWEIL RISTNVRLKAKQLLATRNFQKCLLSLYEFDKIKSKKTGIFQNLINLLKRKTRCYLMNN SDSLIVERVIREGRLTTIKLQINFIITMPGERGKPRNCFLPMSKISIALWKGGERFNQ IDLDEICYGLIKEYGVKTGLKEICNVCLFPDMYAR" gene complement(518734..520233) /gene="IRC15" /locus_tag="YPL017C" mRNA complement(518734..520233) /gene="IRC15" /locus_tag="YPL017C" /product="Irc15p" CDS complement(518734..520233) /gene="IRC15" /locus_tag="YPL017C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005874 microtubule [PMID:19285398]" /experiment="EXISTENCE:direct assay:GO:0007020 microtubule nucleation [PMID:19285398]" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:19285398]" /experiment="EXISTENCE:direct assay:GO:0016651 oxidoreductase activity, acting on NAD(P)H [PMID:30267443]" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:18085829]" /experiment="EXISTENCE:mutant phenotype:GO:0034453 microtubule anchoring [PMID:19285398]" /experiment="EXISTENCE:mutant phenotype:GO:0045144 meiotic sister chromatid segregation [PMID:18069899]" /experiment="EXISTENCE:mutant phenotype:GO:0045931 positive regulation of mitotic cell cycle [PMID:19285398]" /experiment="EXISTENCE:mutant phenotype:GO:0051315 attachment of mitotic spindle microtubules to kinetochore [PMID:19285398]" /note="Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci; IRC15 has a paralog, LPD1, that arose from the whole genome duplication" /codon_start=1 /product="Irc15p" /protein_id="DAA11411.1" /db_xref="SGD:S000005938" /translation="MGGEDEILSTMEDFAAVYDVLVIGCGPGGFTAAMQASQAGLLTA CVDQRASLGGAYLVDGAVPSKTLLYESYLYRLLQQQELIEQRGTRLFPAKFDMQAAQS ALKHNIEELGNVYKRELSKNNVTVYKGTAAFKDPHHVEIAQRGMKPFIVEAKYIVVAT GSAVIQCPGVAIDNDKIISSDKALSLDYIPSRFTIMGGGTIGLEIACIFNNLGSRVTI VESQSEICQNMDNELASATKTLLQCQGIAFLLDTRVQLAEADAAGQLNITLLNKVSKK TYVHHCDVLMVSIGRRPLLKGLDISSIGLDERDFVENVDVQTQSLLKYPHIKPIGDVT LGPMLALKAEEQAIRAIQSIGCTGSDGTSNCGFPPNVLYCQPQIGWVGYTEEGLAKAR IPYQKGRVLFSQNVRYNTLLPREENTTVSPFIKVLIDSRDMKILGVHMINDDANELLS QASMAVSLGLTAHDVCKVPFPHPSLSESFKQAVQLAMANGTSPGVHVRE" gene 521014..524958 /gene="SWI1" /locus_tag="YPL016W" /gene_synonym="ADR6" /gene_synonym="GAM3" /gene_synonym="LPA1" mRNA 521014..524958 /gene="SWI1" /locus_tag="YPL016W" /gene_synonym="ADR6" /gene_synonym="GAM3" /gene_synonym="LPA1" /product="Swi1p" CDS 521014..524958 /gene="SWI1" /locus_tag="YPL016W" /gene_synonym="ADR6" /gene_synonym="GAM3" /gene_synonym="LPA1" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:3143101]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:8016655]" /experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:8016655|PMID:18644858|PMID:8159677|PMID:8127913]" /experiment="EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:10198436]" /experiment="EXISTENCE:mutant phenotype:GO:0016514 SWI/SNF complex [PMID:8159677]" /experiment="EXISTENCE:mutant phenotype:GO:0031496 positive regulation of mating type switching [PMID:6436497]" /experiment="EXISTENCE:mutant phenotype:GO:0034198 cellular response to amino acid starvation [PMID:10549298]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10549298|PMID:3542227|PMID:8016655|PMID:1339306]" /experiment="EXISTENCE:mutant phenotype:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:14580348]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:14580348|PMID:11865042]" /note="Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; self-assembles to form [SWI+] prion and to alter expression pattern; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer" /codon_start=1 /product="Swi1p" /protein_id="DAA11412.1" /db_xref="SGD:S000005937" /translation="MDFFNLNNNNNNNNTTTTTTTTNNNNTNNNNTNNNNNPANNTNN NNSTGHSSNTNNNTNNNNTNTGASGVDDFQNFFDPKPFDQNLDSNNNNSNSNNNDNNN SNTVASSTNFTSPTAVVNNAAPANVTGGKAANFIQNQSPQFNSPYDSNNSNTNLNSLS PQAILAKNSIIDSSNLPLQAQQQLYGGNNNNNSTGIANDNVITPHFITNVQSISQNSS SSTPNTNSNSTPNANQQFLPFNNSASNNGNLTSNQLISNYAASNSMDRSSSASNEFVP NTSDNNNNSNNHNMRNNSNNKTSNNNNVTAVPAATPANTNNSTSNANTVFSERAAMFA ALQQKQQQRFQALQQQQQQQQNQQQQNQQPQQQQQQQQNPKFLQSQRQQQQRSILQSL NPALQEKISTELNNKQYELFMKSLIENCKKRNMPLQSIPEIGNRKINLFYLYMLVQKF GGADQVTRTQQWSMVAQRLQISDYQQLESIYFRILLPYERHMISQEGIKETQAKRIFL QQFLQELLKKVQQQQQAAALANANNNINSASSAPTPAAPGASVPATAAPGTEAGIVPV SANTPKSLNSNININVNNNNIGQQQVKKPRKQRVKKKTKKELELERKEREDFQKRQQK LLEDQQRQQKLLLETKLRQQYEIELKKLPKVYKRSIVRNYKPLINRLKHYNGYDINYI SKIGEKIDSNKPIFLFAPELGAINLHALSMSLQSKNLGEINTALNTLLVTSADSNLKI SLVKYPELLDSLAILGMNLLSNLSQNVVPYHRNTSDYYYEDAGSNQYYVTQHDKMVDK IFEKVNNNATLTPNDSNDEKVTILVDSLTGNQLPTPTPTEMEPDLDTECFISMQSTSP AVKQWDLLPEPIRFLPNQFPLKIHRTPYLTSLKKIKDEIDDPFTKINTRGAEDPKVLI NDQLSTISMILRNISFSDNNSRIMSRNFYLKRFISDLLWLVLIHPENFTCNRKILNFK KDLVIVLSNISHLLEIASSIDCLLILILVISFGQPKLNPMASSSSFGSESLTFNEFQL QWGKYQTFGVDILAKLFSLEKPNLNYFKSILLNKNTGNNLYDRNSNNNHKDKKLLRRL LNLYNDNNKNNNNRHNLLNDVVSFLFSAIPLQQVLSQSADPSLLIDQFSPVISQSLTS ILVIVQKILPLSNEVFEISENNSDSNSNNNGNKDSSFNFNKNLPFVWLSSEENIGSGL LKLSEIILNINNSTSKNTLLQQQNYSKVLLPSINISCVQLIKCLVEKSICFENCLNND PEILKKIASIPNLFPTDLEIFQLFTNPSVDIQIINQYQLLYNLKNDILTNLE" gene complement(525810..526883) /gene="HST2" /locus_tag="YPL015C" mRNA complement(525810..526883) /gene="HST2" /locus_tag="YPL015C" /product="histone deacetylase HST2" CDS complement(525810..526883) /gene="HST2" /locus_tag="YPL015C" /EC_number="2.3.1.286" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17110954]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11226170]" /experiment="EXISTENCE:direct assay:GO:0017136 histone deacetylase activity, NAD-dependent [PMID:10811920]" /experiment="EXISTENCE:genetic interaction:GO:0045950 negative regulation of mitotic recombination [PMID:16051752]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:16051752|PMID:11226170]" /experiment="EXISTENCE:mutant phenotype:GO:0017136 histone deacetylase activity, NAD-dependent [PMID:10841563]" /experiment="EXISTENCE:mutant phenotype:GO:0045950 negative regulation of mitotic recombination [PMID:16051752]" /note="Cytoplasmic NAD(+)-dependent protein deacetylase; deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export" /codon_start=1 /product="histone deacetylase HST2" /protein_id="DAA11413.1" /db_xref="SGD:S000005936" /translation="MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDF RSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKL FQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLA EHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPL VIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQ LVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQR LNGHDSDEDGASNSSSSQKAAKE" gene 527547..528692 /gene="CIP1" /locus_tag="YPL014W" mRNA 527547..528692 /gene="CIP1" /locus_tag="YPL014W" /product="Cip1p" CDS 527547..528692 /gene="CIP1" /locus_tag="YPL014W" /experiment="EXISTENCE:direct assay:GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity [PMID:27005485]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:27005485]" /experiment="EXISTENCE:genetic interaction:GO:0001933 negative regulation of protein phosphorylation [PMID:27005485]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:27005485]" /experiment="EXISTENCE:mutant phenotype:GO:0001933 negative regulation of protein phosphorylation [PMID:27005485]" /note="Cyclin-dependent kinase inhibitor; activated by environmental stress; interacts with and inhibits the Cdc28p/Cln2p, G1/S phase cyclin-dependent kinase complex but not S-phase, or M-phase complexes; overexpression blocks cells in G1 phase and stabilizes the Cdc28p inhibitor Sic1p, while disruption accelerates the G1/S phase transition; phosphorylated during S phase in a Cdc28p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus" /codon_start=1 /product="Cip1p" /protein_id="DAA11414.1" /db_xref="SGD:S000005935" /translation="MLLERLHKRLHAGSSRRSQENKDKNCKPEDALPIQPEAQHQTQD PQPLLNCDYDDMIAFDRNLSTPVFTPVMTPINNSSSNQAKSSDASYFPPYLNANRTRQ NSASSLASSVSDFAQNFKQHTFYNNNAQFTSFTPQFVGLLLEVYQNTCSDPTITPFDT TNPPSGILNRVAKAAIQQSELQQLDIGCDRNSWLLTLVRQRLLQEVRKDGYLSRNTSL TSLPPPPPPQFSEMLRVPSPFVNADITDPIPLSNTNSNPNVSSTTSLTNTLNWYSLQR SNVSMKNRNGSSQYISELQPQPILARTNSNNSVSNSNAFSLLTPTPTTDSAFNFNIAL LSRQRSNIISSPLASTRLPTANVSTEESSILPNESLKLKRDLLRLKR" gene complement(528985..529350) /gene="MRPS16" /locus_tag="YPL013C" /gene_synonym="bS16m" mRNA complement(528985..529350) /gene="MRPS16" /locus_tag="YPL013C" /gene_synonym="bS16m" /product="mitochondrial 37S ribosomal protein MRPS16" CDS complement(528985..529350) /gene="MRPS16" /locus_tag="YPL013C" /gene_synonym="bS16m" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the small subunit" /codon_start=1 /product="mitochondrial 37S ribosomal protein bS16m MRPS16" /protein_id="DAA11415.1" /db_xref="SGD:S000005934" /translation="MTCGLVRIRLARFGRKNSPVYNIVVANSRKARDAKPIEVLGTYV PVPSPVTKRELKRGVVPIKDVKLDFDRTKYWIGVGAQPSETVTKLLRKAGILNDAWAT SKNSNVNRKVVFERMETLE" gene 529723..533409 /gene="RRP12" /locus_tag="YPL012W" mRNA 529723..533409 /gene="RRP12" /locus_tag="YPL012W" /product="mRNA-binding protein RRP12" CDS 529723..533409 /gene="RRP12" /locus_tag="YPL012W" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14729571]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /note="Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; also plays a role in the cell cycle and the DNA damage response; contains HEAT-repeats" /codon_start=1 /product="mRNA-binding protein RRP12" /protein_id="DAA11416.1" /db_xref="SGD:S000005933" /translation="MDQDKVAFLLELEDKLAKIRSQVNSKLENQKHIAIILTAVEENI AGQATNDVSKNIVNYIISFMSLLDQAVDPSTHEIKDIQLASSSTYLLDLIFHYSPKVL LRSKFSEILTKIAPCITAEKANAPLIRAAIGCLESLLIAQDAQAWNNTYDLNVTPKRG LQGILELSLDVRPKVRKRALDAVHAVLLNPPVAPTAEHVAAVFVADFCDKQLAGILND LSNLSNKQLKAQKTKEDINASVMRSLRLITSVVSTGQWPSSQIEPLCDVLLGVTKSSE QYLVSASFECFESMFKTMAETTISSGLAENKYLRVLDTIFALKPSNVDTLLTKSWIAV VIKGMSTYATHQPLKALRKIPGVFHIMCTYLASETPEVYQAASQCLISILSESVKDDL LLYTPSVDEKVFKNVDEIISQIAKTFIDFLSIRYSHCSREILKILVAAFNKFRYRSNP HFLKSLKIVDTWRVNEEQFMDLRNEIELVIGASISAMGPEMILAEAPLNLDNPSSERP GRAWLLPLIRDYTKNANLATFQNELAPYIKSFQSKFDKVPEESIQLRVFQTIVDQIWS TLPRFCELPMDLRESFTDEFASELSSLLYSEVELRTTICHALKVLAESNVSYAEESSS HNVLLLQRFPISEAQKNIEYLSTKSTNLLAVLFNVYTQTTPNARSYILETIDQYLKIT SKEDLEKTFNNVCGLLKNSMNEESSGNVNKEKKKPQLTATLLDLIICMITYLPVSSYS ALFSMFSLTVNSADALIQKRAYRIITKLSELKSGSTAVAQFISDIENVMVDSASSVQT SAKAARLTAIKTIVELLPLDHLDFIVRTVAEVILSTKDVNEKSRETAFDTLICMGRKM NEPNGIIKLFQIPGYDPTTPDQSSSISEFFKIISAGLIGESQHMVSSSITGYACLVFE FKNELDSGILMDIYDTIELYLTSNSREIVKSAIGFTKVCVLGLPEELMRPKVPELLLK LLRWSHEHTGHFKAKVKHIIERLIRRFGYDYIEANFPEEDRRLLTNIRKMRNRNKRKD EEVTTGVSDVAATKGSRFMSAFDEAVYGSDEENDNGSDQEENVAGGKMKNGAKQFIVE SGDNPLDLLDSQTLAHISSTRPKKFNKNQNRARFNDDAFNFDSEGKLVVKGQPKPSTN VDDPLSAVTSGINAYLEAVKSGPVRGQRNKLKFRKNGKDSDEFGDDDDGEKDSRLMRG RVNQGNKIGKHNKKGPKFKSRKKL" gene complement(533642..534703) /gene="TAF3" /locus_tag="YPL011C" /gene_synonym="TAF47" mRNA complement(533642..534703) /gene="TAF3" /locus_tag="YPL011C" /gene_synonym="TAF47" /product="Taf3p" CDS complement(533642..534703) /gene="TAF3" /locus_tag="YPL011C" /gene_synonym="TAF47" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:17660549]" /experiment="EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:10788514|PMID:15448131]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:15448131|PMID:12138208]" /note="TFIID subunit (47 kDa); involved in promoter binding and RNA polymerase II transcription initiation" /codon_start=1 /product="Taf3p" /protein_id="DAA11417.1" /db_xref="SGD:S000005932" /translation="MTTNNDFYFALLRISILQLLKAQGFDRARPSLVDVMTDLYAKFL SLLASEVSSIAQARCDQDDTIALQDITLALENLGIVKPTNVLDVYDENSELSSSRGME KFKDWCIYSTQLTDARITALPTVELLQSEEKESDPLSAIPDYLNQLLQNKGAKQKLET KNRKTELIEDLINNNGLDDWIKLVIARQRINMIERASKKESQNVPALPHIAGYKSSIL SRHHHTTITNEDRMPSAMTPRDEDALTEIQENPFVTSKLPIMRKENRLENITLSFEDE ELESLGEVEGPNQKSQENNNEESFKENNKSLTESPHGDDRDISMFQFDSNVDTKWAEQ EDMDSTFQRRTSLDYGGYF" gene 535018..535587 /gene="RET3" /locus_tag="YPL010W" mRNA 535018..535587 /gene="RET3" /locus_tag="YPL010W" /product="coatomer subunit zeta" CDS 535018..535587 /gene="RET3" /locus_tag="YPL010W" /experiment="EXISTENCE:direct assay:GO:0030126 COPI vesicle coat [PMID:21435344]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:8617224]" /experiment="EXISTENCE:mutant phenotype:GO:0030126 COPI vesicle coat [PMID:8617224]" /note="Zeta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER" /codon_start=1 /product="coatomer subunit zeta" /protein_id="DAA11418.1" /db_xref="SGD:S000005931" /translation="MSSLSLYTVQAVLILDQQGERIYAKYYQPPHRSDEGHQLLFNSV KKQKEFEKQLYRKTHKQDSEILIFEDHLVLYKEYIDITIYLVASLEENEIVLQQGFSA IRGALDLILNSGMDKKNIQENYDMVLLAIDETIDNGVILETDSNTIASRVSKPPTNEP QMALDLDKGFLGAWGFAKSKFQERLQQGL" gene complement(535820..538936) /gene="RQC2" /locus_tag="YPL009C" /gene_synonym="TAE2" mRNA complement(535820..538936) /gene="RQC2" /locus_tag="YPL009C" /gene_synonym="TAE2" /product="Rqc2p" CDS complement(535820..538936) /gene="RQC2" /locus_tag="YPL009C" /gene_synonym="TAE2" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:25554787]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23222640|PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:31133701|PMID:25554787]" /experiment="EXISTENCE:direct assay:GO:0043023 ribosomal large subunit binding [PMID:25554787]" /experiment="EXISTENCE:direct assay:GO:0072344 rescue of stalled ribosome [PMID:25554787]" /experiment="EXISTENCE:direct assay:GO:0140708 CAT tailing [PMID:31133701]" /experiment="EXISTENCE:direct assay:GO:1904678 alpha-aminoacyl-tRNA binding [PMID:31133701]" /experiment="EXISTENCE:direct assay:GO:1990112 RQC complex [PMID:23178123]" /experiment="EXISTENCE:genetic interaction:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:23479637]" /experiment="EXISTENCE:mutant phenotype:GO:0043043 peptide biosynthetic process [PMID:25554787]" /experiment="EXISTENCE:mutant phenotype:GO:0072344 rescue of stalled ribosome [PMID:26943317]" /experiment="EXISTENCE:mutant phenotype:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:23479637]" /experiment="EXISTENCE:physical interaction:GO:1990112 RQC complex [PMID:23479637]" /note="Component of the Ribosome Quality Control (RQC) complex; RQC is a ribosome-bound complex required for degradation of polypeptides arising from stalled translation; recruits alanine- and threonine-charged tRNA to the A site and directs noncanonical elongation of nascent chains independently of mRNA or 40S subunits in a process called CAT (carboxyl-terminal alanine and threonine) tailing, promoting LTN1-mediated ubiquitination; monitors translation stress and signals this to Hsf1p" /codon_start=1 /product="Rqc2p" /protein_id="DAA11419.1" /db_xref="SGD:S000005930" /translation="MKQRISALDLLLLARELKQDLEGYRLSNIYNIADSSKQFLLKFN KPDSKLNVVVDCGLRIYLTEFSRPIPPTPSGFVVKLRKHLKAKRLTALKQVDQDRILV LQFADGHFYLVLEFFSAGNVILLDENRRIMALQRVVLEHENKVGQIYEMFDESLFTTN NESADESIEKNRKAEYTSELVNEWIKAVQAKYESDITVIKQLNIQGKEGAKKKKVKVP SIHKLLLSKVPHLSSDLLSKNLKVFNIDPSESCLNLLEETDSLAELLNSTQLEYNQLL TTTDRKGYILAKRNENYISEKDTADLEFIYDTFHPFKPYINGGDTDSSCIIEVEGPYN RTLDKFFSTIESSKYALRIQNQESQAQKKIDDARAENDRKIQALLDVQELNERKGHLI IENAPLIEEVKLAVQGLIDQQMDWNTIEKLIKSEQKKGNRIAQLLNLPLNLKQNKISV KLDLSSKELNTSSDEDNESEGNTTDSSSDSDSEDMESSKERSTKSMKRKSNEKINVTI DLGLSAYANATEYFNIKKTSAQKQKKVEKNVGKAMKNIEVKIDQQLKKKLKDSHSVLK KIRTPYFFEKYSWFISSEGFLVMMGKSPAETDQIYSKYIEDDDIYMSNSFNSHVWIKN PEKTEVPPNTLMQAGILCMSSSEAWSKKISSSPWWCFAKNVSKFDGSDNSILPEGAFR LKNENDQNHLPPAQLVMGFGFLWKVKTSGNEDNGDDDEEEEEEEEEEEEEEEEEEEEE EEEKEEEEKEEEQQQDEDDSNEVNGLEKGGDSNDSTKNNSFEHDNLEKDIEKHCTISS DTDSDSGNAKAKNDNSSTQRILDEPGVPISLIENINSNVRGKRGKLKKIQKKYADQDE TERLLRLEALGTLKGIEKQQQRKKEEIMKREVREDRKNKREKQRRLQALKFTKKEKAR VNYDKHKSELKPSLDKGDVVDDIIPVFAPWPALLKYKYKVKIQPGSAKKTKTLTEILH YFKSRPLDGSSTDNEMDWPQEHEMIKGLKEQDLVLLLCVDKLKVTIAGQKSTKNGGNS SKKGKKKR" gene 539385..541970 /gene="CHL1" /locus_tag="YPL008W" /gene_synonym="CTF1" /gene_synonym="LPA9" /gene_synonym="MCM12" mRNA 539385..541970 /gene="CHL1" /locus_tag="YPL008W" /gene_synonym="CTF1" /gene_synonym="LPA9" /gene_synonym="MCM12" /product="DNA helicase" CDS 539385..541970 /gene="CHL1" /locus_tag="YPL008W" /gene_synonym="CTF1" /gene_synonym="LPA9" /gene_synonym="MCM12" /EC_number="5.6.2.3" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714|PMID:17483413|PMID:15020404]" /experiment="EXISTENCE:genetic interaction:GO:0036297 interstrand cross-link repair [PMID:22912599]" /experiment="EXISTENCE:mutant phenotype:GO:0000785 chromatin [PMID:24086532]" /experiment="EXISTENCE:mutant phenotype:GO:0003678 DNA helicase activity [PMID:10931920]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:15020404|PMID:14742714]" /experiment="EXISTENCE:mutant phenotype:GO:0031571 mitotic G1 DNA damage checkpoint signaling [PMID:34493312]" /experiment="EXISTENCE:mutant phenotype:GO:0034085 establishment of sister chromatid cohesion [PMID:23334284]" /experiment="EXISTENCE:physical interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:15020404]" /note="Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome" /codon_start=1 /product="DNA helicase" /protein_id="DAA11420.1" /db_xref="SGD:S000005929" /translation="MDKKEYSETFYHPYKPYDIQVQLMETVYRVLSEGKKIAILESPT GTGKTLSLICATMTWLRMNKADIFTRMETNIKTNEDDSENLSDDEPDWVIDTYRKSVL QEKVDLLNDYEKHLNEINTTSCKQLKTMCDLDKEHGRYKSVDPLRKKRKGARHLDVSL EEQDFIPRPYESDSENNDTSKSTRGGRISDKDYKLSELNSQIITLLDKIDGKVSRDPN NGDRFDVTNQNPVKIYYASRTYSQLGQFTSQLRLPSFPSSFRDKVPDEKVKYLPLASK KQLCINPKVMKWKTLEAINDACADLRHSKEGCIFYQNTNEWRHCPDTLALRDMIFSEI QDIEDLVPLGKSLGICPYYASREALPIAEVVTLPYQYLLSESTRSSLQINLENSIVII DEAHNLIETINSIYSSQISLEDLKNCHKGIVTYFNKFKSRLNPGNRVNLLKLNSLLMT LIQFIVKNFKKIGQEIDPNDMFTGSNIDTLNIHKLLRYIKVSKIAYKIDTYNQALKEE ESSKNENPIKETHKKSVSSQPLLFKVSQFLYCLTNLTSEGQFFFEKNYSIKYMLLEPS KPFESILNQAKCVVLAGGTMEPMSEFLSNLLPEVPSEDITTLSCNHVIPKENLQTYIT NQPELEFTFEKRMSPSLVNNHLFQFFVDLSKAVPKKGGIVAFFPSYQYLAHVIQCWKQ NDRFATLNNVRKIFYEAKDGDDILSGYSDSVAEGRGSLLLAIVGGKLSEGINFQDDLC RAVVMVGLPFPNIFSGELIVKRKHLAAKIMKSGGTEEEASRATKEFMENICMKAVNQS VGRAIRHANDYANIYLLDVRYNRPNFRKKLSRWVQDSINSEHTTHQVISSTRKFFSMR SLNSR" gene complement(542082..543848) /gene="TFC8" /locus_tag="YPL007C" mRNA complement(542082..543848) /gene="TFC8" /locus_tag="YPL007C" /product="transcription factor TFIIIC subunit TFC8" CDS complement(542082..543848) /gene="TFC8" /locus_tag="YPL007C" /experiment="EXISTENCE:direct assay:GO:0000127 transcription factor TFIIIC complex [PMID:10567530|PMID:2002052|PMID:1474578]" /experiment="EXISTENCE:direct assay:GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding [PMID:2404611|PMID:2649882]" /experiment="EXISTENCE:direct assay:GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding [PMID:2404611]" /experiment="EXISTENCE:direct assay:GO:0006383 transcription by RNA polymerase III [PMID:2183033|PMID:3633923|PMID:8464480]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:2002052]" /experiment="EXISTENCE:direct assay:GO:0042791 5S class rRNA transcription by RNA polymerase III [PMID:2183033]" /experiment="EXISTENCE:genetic interaction:GO:0006383 transcription by RNA polymerase III [PMID:10567530]" /experiment="EXISTENCE:mutant phenotype:GO:0006383 transcription by RNA polymerase III [PMID:10567530]" /note="Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90" /codon_start=1 /product="transcription factor TFIIIC subunit TFC8" /protein_id="DAA11421.1" /db_xref="SGD:S000005928" /translation="MKLLKDLLVDRKEFEDWKNNLTWARDGTLYLTTFPDISIGQPKY AKDINCNSKNLFHVKEFPLEFENKLDFELAQQNGLLNSQPVCYPRVCKPSPIDDWMAV LSNNGNVSVFKDNKMLTNLDSKGNLSSRTYHCFEWNPIESSIVVGNEDGELQFFSIRK NSENTPEFYFESSIRLSDAGSKDWVTHIVWYEDVLVAALSNNSVFSMTVSASSHQPVS RMIQNASRRKITDLKIVDYKVVLTCPGYVHKIDLKNYSISSLKTGSLENFHIIPLNHE KESTILLMSNKTSYKVLLEDELHVTADNIIAPYLEKKFKKWSTIWNEFNNYETTLVIH GISLSPDGYSIAIVYDMERVAFKYKIASEQSFNIMFAPLYHTWTISERAVGLAWYQTY QIYNQSLPKLPENFSMNKKLLNGNYPISLDFQSYLNALMKSEEMRIIMFLNMTIDKPS ILSFLEALYEYAINKKSELTNSFDLACVLSIAAILKREAPIYNGTLLMKNSFLEETFN LESFTADPETVTSTTNNTWKRCGVTLLPILTTHVKICPVSKQRVIDIKRDDLNDYGWF TRGLLERFNEISVYCGTTLEVM" gene 544631..548143 /gene="NCR1" /locus_tag="YPL006W" mRNA 544631..548143 /gene="NCR1" /locus_tag="YPL006W" /product="sphingolipid transporter" CDS 544631..548143 /gene="NCR1" /locus_tag="YPL006W" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095|PMID:16138904]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0015918 sterol transport [PMID:31543266]" /experiment="EXISTENCE:direct assay:GO:0032934 sterol binding [PMID:31543266]" /experiment="EXISTENCE:mutant phenotype:GO:0006665 sphingolipid metabolic process [PMID:14970192]" /note="Vacuolar membrane protein involved in sterol trafficking with Npc2p; conformational changes drive sterol translocation across the glycocalyx and into the vacuolar membrane; involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCBs), similar to accumulation of lipids observed in patients with Neimann-Pick C disease due to loss-of-function mutations in human NPC1; transits through the vacuolar protein sorting pathway via the AP-3 pathway" /codon_start=1 /product="sphingolipid transporter" /protein_id="DAA11422.1" /db_xref="SGD:S000005927" /translation="MNVLWIIALVGQLMRLVQGTATCAMYGNCGKKSVFGNELPCPVP RSFEPPVLSDETSKLLVEVCGEEWKEVRYACCTKDQVVALRDNLQKAQPLISSCPACL KNFNNLFCHFTCAADQGRFVNITKVEKSKEDKDIVAELDVFMNSSWASEFYDSCKNIK FSATNGYAMDLIGGGAKNYSQFLKFLGDAKPMLGGSPFQINYKYDLANEEKEWQEFND EVYACDDAQYKCACSDCQESCPHLKPLKDGVCKVGPLPCFSLSVLIFYTICALFAFMW YYLCKRKKNGAMIVDDDIVPESGSLDESETNVFESFNNETNFFNGKLANLFTKVGQFS VENPYKILITTVFSIFVFSFIIFQYATLETDPINLWVSKNSEKFKEKEYFDDNFGPFY RTEQIFVVNETGPVLSYETLHWWFDVENFITEELQSSENIGYQDLCFRPTEDSTCVIE SFTQYFQGALPNKDSWKRELQECGKFPVNCLPTFQQPLKTNLLFSDDDILNAHAFVVT LLLTNHTQSANRWEERLEEYLLDLKVPEGLRISFNTEISLEKELNNNNDISTVAISYL MMFLYATWALRRKDGKTRLLLGISGLLIVLASIVCAAGFLTLFGLKSTLIIAEVIPFL ILAIGIDNIFLITHEYDRNCEQKPEYSIDQKIISAIGRMSPSILMSLLCQTGCFLIAA FVTMPAVHNFAIYSTVSVIFNGVLQLTAYVSILSLYEKRSNYKQITGNEETKESFLKT FYFKMLTQKRLIIIIFSAWFFTSLVFLPEIQFGLDQTLAVPQDSYLVDYFKDVYSFLN VGPPVYMVVKNLDLTKRQNQQKICGKFTTCERDSLANVLEQERHRSTITEPLANWLDD YFMFLNPQNDQCCRLKKGTDEVCPPSFPSRRCETCFQQGSWNYNMSGFPEGKDFMEYL SIWINAPSDPCPLGGRAPYSTALVYNETSVSASVFRTAHHPLRSQKDFIQAYSDGVRI SSSFPELDMFAYSPFYIFFVQYQTLGPLTLKLIGSAIILIFFISSVFLQNIRSSFLLA LVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIVRSFTVVPSETKKDA NSRVLYSLNTIGESVIKGITLTKFIGVCVLAFAQSKIFDVFYFRMWFTLIIVAALHAL LFLPALLSLFGGESYRDDSIEAED" gene 548486..550306 /gene="AEP3" /locus_tag="YPL005W" mRNA 548486..550306 /gene="AEP3" /locus_tag="YPL005W" /product="Aep3p" CDS 548486..550306 /gene="AEP3" /locus_tag="YPL005W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0070124 mitochondrial translational initiation [PMID:19843529]" /experiment="EXISTENCE:mutant phenotype:GO:0016071 mRNA metabolic process [PMID:14742425]" /note="Peripheral mitochondrial inner membrane protein; may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; stabilizes the bicistronic AAP1-ATP6 mRNA" /codon_start=1 /product="Aep3p" /protein_id="DAA11423.1" /db_xref="SGD:S000005926" /translation="MNTLRCLTQALSKSGREAPKLYQKVIFPGLFREGIPIANVKKVD EKIIDSPTSTSVNGEAKKIVRHGVKYEREQVKEYLSSLPTLTLSRKQIRDDYDEERAK RMYMFSKQTNSSNKFQKLLTAKSQEFTRELLTLLIDCTSNEKNSGPERFTRKFLKFSN DEIPPLPDFSKNPQLFENYIGILSHTKFNFRSSSKLNGIVRKMLRHLLHPTNKTTLPL RSAQVYNDSIYFFSEHFDFASCREIFAQMKAEGTKPNTITFNLLLRNVVKNSHIRKTK HPDDEVLFYLRSMRNHGVFADVITWTTCYNFLRDEVSRQLYIVQMGEHLGNFNVNFVY TVLRNGDYRAEDCLKVLAANSLPISRKTFYLCIERLLNEEQLETASKLLDYGFQHLKS NFKLDSEAMNHFMRVFANKGRSDLAFLCYNTCRKIYKIKPDSQTFEMLFKALVRNGNT KNFGAVLQYIKDLKVSEGFGLRTSYWRTKADSIFKFGSPNTLSEKSIEKARKLLGNLI ASEGEFSWKIWKESDSSQKKILRFLGCIPTTLRCTNTAQDHQKPTNLPSNISQKKREY RNRVKAIATKAALEKRMAYIKDNDVAFKKELVKRRIVGEV" gene complement(550632..551657) /gene="LSP1" /locus_tag="YPL004C" mRNA complement(550632..551657) /gene="LSP1" /locus_tag="YPL004C" /product="lipid-binding protein LSP1" CDS complement(550632..551657) /gene="LSP1" /locus_tag="YPL004C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:22123866]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:16496001]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:16496001]" /experiment="EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:15016821]" /experiment="EXISTENCE:mutant phenotype:GO:0061024 membrane organization [PMID:38096056]" /experiment="EXISTENCE:mutant phenotype:GO:0070941 eisosome assembly [PMID:36601791]" /note="Stress-responsive eisosome organizer and core component; eisosomes are large immobile patch structures at the cell cortex associated with endocytosis; phosphorylated on Thr233 upon Pkc1p hyperactivation in a Slt2p MAPK-dependent fashion; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family" /codon_start=1 /product="lipid-binding protein LSP1" /protein_id="DAA11424.1" /db_xref="SGD:S000005925" /translation="MHRTYSLRNQRAPTAAELQAPPPPPSSTKSKFFGKASIASSFRK NAAGNFGPELARKLSQLVKTEKGVLRAMEVVASERREAAKQLSLWGADNDDDVSDVTD KLGVLIYELGELQDQFIDKYDQYRVTLKSIRNIEASVQPSRDRKEKITDEIAHLKYKD PQSTKIPVLEQELVRAEAESLVAEAQLSNITREKLKAAYSYMFDSLRELSEKFALIAG YGKALLELLDDSPVTPGEARPAYDGYEASRQIIMDAESALESWTLDMAAVKPTLSFHQ TVDDVYEDEDGEEEEEPEIQNGDIPGQVVEEEEVEWTTEVPVDDEAHEADHHVSQNGH TSGSENI" gene 552020..553408 /gene="ULA1" /locus_tag="YPL003W" /gene_synonym="ENR2" mRNA 552020..553408 /gene="ULA1" /locus_tag="YPL003W" /gene_synonym="ENR2" /product="Ula1p" CDS 552020..553408 /gene="ULA1" /locus_tag="YPL003W" /gene_synonym="ENR2" /experiment="EXISTENCE:direct assay:GO:0019781 NEDD8 activating enzyme activity [PMID:9545234]" /experiment="EXISTENCE:direct assay:GO:0045116 protein neddylation [PMID:9545234]" /experiment="EXISTENCE:mutant phenotype:GO:0019781 NEDD8 activating enzyme activity [PMID:9531531]" /experiment="EXISTENCE:mutant phenotype:GO:0045116 protein neddylation [PMID:9545234]" /note="Protein that activates Rub1p (NEDD8) before neddylation; acts together with Uba3p; may play a role in protein degradation" /codon_start=1 /product="Ula1p" /protein_id="DAA11425.1" /db_xref="SGD:S000005924" /translation="MERYDRQLRLWGALGQDSLNRSRVCVVGPATPLLQEVFKNLVLA GISSLTWLKVECAVQSGSLFLAELKKDLEPLASKQLEYEENDLRKTLQQPQYDWTRFS VVILTCIGEQTAMLDLNEIRRQRGTKFPPVLNTFVSGFYGYIYLVLSETHFVLQAHPD SKKYDLRLQNPWPELINYVDTFDLSKMDTATFSGIPYTVLLMKCIAKLERDGNNGRIT IDQMKKVLDQICLPLGNDVIYEPNYVEAKRYAYLACSQNDCCKELEDLLRNLEISDYG NDWHDTYNYEILTLLLTLKNIAKENGELSFQPLTGTLPDMESTTENYIRLKKLYEVKA KLDKSRVEESLARSKKIVSQDVLETFCSHYGEVRKILPPKSDLLGIFSTSNALLDALV MVQFWEQPAVTAEDKDEFIGLRVDDNYSVMAFFGGAVVQEAIKLITHHYVPIDNLFLY NGINNSSATYKI" gene complement(553627..554328) /gene="SNF8" /locus_tag="YPL002C" /gene_synonym="VPL14" /gene_synonym="VPS22" mRNA complement(553627..554328) /gene="SNF8" /locus_tag="YPL002C" /gene_synonym="VPL14" /gene_synonym="VPS22" /product="ESCRT-II subunit protein SNF8" CDS complement(553627..554328) /gene="SNF8" /locus_tag="YPL002C" /gene_synonym="VPL14" /gene_synonym="VPS22" /experiment="EXISTENCE:direct assay:GO:0000814 ESCRT II complex [PMID:12194858]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:7785322]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12194858]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /note="Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression" /codon_start=1 /product="ESCRT-II subunit protein SNF8" /protein_id="DAA11426.1" /db_xref="SGD:S000005923" /translation="MKQFGLAAFDELKDGKYNDVNKTILEKQSVELRDQLMVFQERLV EFAKKHNSELQASPEFRSKFMHMCSSIGIDPLSLFDRDKHLFTVNDFYYEVCLKVIEI CRQTKDMNGGVISFQELEKVHFRKLNVGLDDLEKSIDMLKSLECFEIFQIRGKKFLRS VPNELTSDQTKILEICSILGYSSISLLKANLGWEAVRSKSALDEMVANGLLWIDYQGG AEALYWDPSWITRQL" gene 554605..555729 /gene="HAT1" /locus_tag="YPL001W" /gene_synonym="KAT1" mRNA 554605..555729 /gene="HAT1" /locus_tag="YPL001W" /gene_synonym="KAT1" /product="histone acetyltransferase catalytic subunit HAT1" CDS 554605..555729 /gene="HAT1" /locus_tag="YPL001W" /gene_synonym="KAT1" /EC_number="2.3.1.48" /experiment="EXISTENCE:direct assay:GO:0000123 histone acetyltransferase complex [PMID:9575221|PMID:8858151]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:16612003]" /experiment="EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:7559580|PMID:8858151]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9575221|PMID:14761951]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9575221|PMID:8858151]" /experiment="EXISTENCE:direct assay:GO:0006302 double-strand break repair [PMID:16612003]" /experiment="EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:15099519|PMID:10982821]" /experiment="EXISTENCE:mutant phenotype:GO:0004402 histone acetyltransferase activity [PMID:8858151|PMID:7559580|PMID:9575221]" /experiment="EXISTENCE:physical interaction:GO:0000123 histone acetyltransferase complex [PMID:8858151]" /note="Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex; uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair" /codon_start=1 /product="histone acetyltransferase catalytic subunit HAT1" /protein_id="DAA11427.1" /db_xref="SGD:S000005922" /translation="MSANDFKPETWTSSANEALRVSIVGENAVQFSPLFTYPIYGDSE KIYGYKDLIIHLAFDSVTFKPYVNVKYSAKLGDDNIVDVEKKLLSFLPKDDVIVRDEA KWVDCFAEERKTHNLSDVFEKVSEYSLNGEEFVVYKSSLVDDFARRMHRRVQIFSLLF IEAANYIDETDPSWQIYWLLNKKTKELIGFVTTYKYWHYLGAKSFDEDIDKKFRAKIS QFLIFPPYQNKGHGSCLYEAIIQSWLEDKSITEITVEDPNEAFDDLRDRNDIQRLRKL GYDAVFQKHSDLSDEFLESSRKSLKLEERQFNRLVEMLLLLNNSPSFELKVKNRLYIK NYDALDQTDPEKAREALQNSFILVKDDYRRIIESINKSQG" centromere 555957..556073 /note="CEN16; Chromosome XVI centromere" /db_xref="SGD:S000006477" centromere 555957..555966 /note="CEN16_CDEI of CEN16" centromere 555967..556048 /note="CEN16_CDEII of CEN16" centromere 556049..556073 /note="CEN16_CDEIII of CEN16" gene 556377..557837 /gene="CIT3" /locus_tag="YPR001W" mRNA 556377..557837 /gene="CIT3" /locus_tag="YPR001W" /product="citrate (Si)-synthase CIT3" CDS 556377..557837 /gene="CIT3" /locus_tag="YPR001W" /EC_number="2.3.3.1" /experiment="EXISTENCE:direct assay:GO:0004108 citrate (Si)-synthase activity [PMID:17570335]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:9140965|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006099 tricarboxylic acid cycle [PMID:17570335]" /experiment="EXISTENCE:direct assay:GO:0050440 2-methylcitrate synthase activity [PMID:17570335]" /experiment="EXISTENCE:genetic interaction:GO:0019629 propionate catabolic process, 2-methylcitrate cycle [PMID:17570335]" /experiment="EXISTENCE:mutant phenotype:GO:0004108 citrate (Si)-synthase activity [PMID:17570335]" /experiment="EXISTENCE:mutant phenotype:GO:0050440 2-methylcitrate synthase activity [PMID:17570335]" /note="Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate" /codon_start=1 /product="citrate (Si)-synthase CIT3" /protein_id="DAA11428.1" /db_xref="SGD:S000006205" /translation="MVQRLLPGAHICRRSFNSSAIIKSSALTLKEALENVIPKKRDAV KKLKACYGSTFVGPITISSVLGGMRGNQSMFWQGTSLDPEHGIKFQGLTIEECQNRLP NTGIDGDNFLPESMLWLLMTGGVPTFQQAASFRKELAIRGRKLPHYTEKVLSSLPKDM HPMTQLAIGLASMNKGSLFATNYQKGLIGKMEFWKDTLEDSLNLIASLPLLTGRIYSN ITNEGHPLGQYSEEVDWCTNICSLLGMTNGTNSSNTCNLTSQQSLDFINLMRLYTGIH VDHEGGNVSAHTTHLVGSALSDPYLSYSSGIMGLAGPLHGLAAQEVVRFLIEMNSNIS SIAREQEIKDYLWKILNSNRVIPGYGHAVLRKPDPRFTAMLEFAQKRPIEFENDKNVL LMQKLAEIAPKVLLEHGKSKNPFPNVDSASGILFYHYGIRELLFFTVIFGCSRAMGPL TQLVWDRILGLPIERPKSLNLEGLEALTKASNVNKL" gene 558385..559935 /gene="PDH1" /locus_tag="YPR002W" mRNA 558385..559935 /gene="PDH1" /locus_tag="YPR002W" /product="putative 2-methylcitrate dehydratase" CDS 558385..559935 /gene="PDH1" /locus_tag="YPR002W" /EC_number="4.2.1.79" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:mutant phenotype:GO:0019541 propionate metabolic process [PMID:11179416]" /note="Putative 2-methylcitrate dehydratase; mitochondrial protein that participates in respiration; induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate" /codon_start=1 /product="putative 2-methylcitrate dehydratase" /protein_id="DAA11429.1" /db_xref="SGD:S000006206" /translation="MFLAKNLKNNKIKVCLPKKKFAALSTASIQTNERPNPDKVLKDI AKYVHETPLKSSLALDTARLCFLDTLGCGLAALKFKQAQNIIKPIVPGTIVPSGTKIL GTSYVMDPVKGAFAIGTLIRWLDYNDCWLAAEWGHPSDNLGGILAVADHLSRLNKATH GKNGKQFLVKDVLEAMIKAHEIQGIIALENSFNKVGLDHVVLVKVATAGVVSKMLGLS QEQTIEALSQAFVDGQSLRTYRHAPNTGSRKSWAAGDAVSRAVNLAYLVKNANVGTIP SVLTARTWGFYDVLFKGKPFSFQQRSKYDSYVMENVLFKISFPAEFHAQTAVEAAVKA YRILAKQGKTFKDIKSIRIRTQEAAMRIIDKSGPLYNYADRDHCIQYMIAVPLITGNL TATDYSDEVARNPEIDNLRSKMYCIEDTHLTQNYHDPDKRSIGNALLIELNDGTQLDE IFVEYPVGHKFRREEGIPLLMNKFQRHLREHFVESPDKVDLIMKVSSKTNFLNMQIDK YMDLFTEG" gene complement(560198..560289) /locus_tag="YNCP0008C" tRNA complement(join(560198..560233,560253..560289)) /locus_tag="YNCP0008C" /product="tRNA-Phe" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:10024171]" /note="Phenylalanine tRNA (tRNA-Phe), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006570" repeat_region 560481..560812 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007210" gene complement(561504..563768) /locus_tag="YPR003C" mRNA complement(561504..563768) /locus_tag="YPR003C" /product="hypothetical protein" CDS complement(561504..563768) /locus_tag="YPR003C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /note="Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11430.1" /db_xref="SGD:S000006207" /translation="MTSNNSLLGRGRMSYSSTAPPRFKRSVDQRDTFSDNFDYDKDSS NRGRTYIAASNSTTGVPPPNNSRSGCTNNTNNTNNTSNTSNTNNNDSVDENTVFETLP YYLPCFSWLPEYTFNKLWGDVIAGISVASFQIPLALSYTTSIAHVPPLCGLYSLAISP FVYGILGSVPQMIVGPESAISLVVGQAVESITLHKENVSLIDISTVITFVSGTILLFS GISRFGFLGNVLSKALLRGFISSVGLVMIINSLISELKLDKFLVSLPQHYHTPFEKIL FLIDYAPAQYHIPTAIFSGCCLIVLFLTRLLKRKLMKYHKSAIFFPDILLVVIVTILI SMKFNLKHRYGISIIGDFSMDNFDELKNPLTRPRRKLIPDLFSASLIVAMLGFFESTT ASKSLGTTYNLTVSSNRELVALGFMNIVISLFGALPAFGGYGRSKINALSGAQSVMSG VFMGVITLITMNLLLQFVHYIPNCVLSVITTIIGISLLEEVPGDIKFHLRCGGFSELF VFAVTFCTTIFYSIEAGICIGCVYSIINIIKHSAKSRIQILARVAGTSNFTNLDDYMM NMKRNSLDVEGTEEIEGCMIVRIPEPLTFTNSEDLKQRLDRIERYGSSKIHPGRKSLR SKDSIKYVIFDLGGMTSIDSSAAQVLEEIITSYKRRNVFIYLVNVSINDKVRRRLFKA GVAASVERAQANNNENNTSNTFSDAGETYSPYFDSIDAALYEIEKMKIKGNNVPNNDS ESFMSNTLFNSSLV" rep_origin 563852..563967 /note="ARS1622; Autonomously Replicating Sequence" /db_xref="SGD:S000118418" gene complement(564007..565041) /gene="AIM45" /locus_tag="YPR004C" mRNA complement(564007..565041) /gene="AIM45" /locus_tag="YPR004C" /product="Aim45p" CDS complement(564007..565041) /gene="AIM45" /locus_tag="YPR004C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:14562095|PMID:11502169|PMID:17054397|P MID:16823961|PMID:24769239]" /note="Putative ortholog of mammalian ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response; ETF-alpha is an electron transfer flavoprotein complex subunit" /codon_start=1 /product="Aim45p" /protein_id="DAA11431.1" /db_xref="SGD:S000006208" /translation="MFKSLAAVLPRASKAKFLQKNYASTLAFIESSKDGSVSRSSLSL LAAAQKLSNPITAVITGSKAEKTAEALKSSYSCSNLEKLVIFEDSKLDTCLPEQLTPL LVKLLKGGDYSHFVVSNSSVGKSVLPRVGALLDVQPVCEVTVIKDPKTFIRPIYAGNI ISTIECQAEKKLLIIRASAFPPIAEGSMDSVTIEKRTDIPPCDLNVTWVKTILTKSER PELTSAQNVVTGGRALKDKETFEKLLSPLADVLHAAIGATRASVDNGLCDNSLQIGQT GKVVAPNLYIAIGVSGAVQHLAGMKDSKVIVAINNDPDAPIFNVADYGLQGDLYKIVP ELTEKLGKYK" rep_origin 565052..565294 /note="ARS1634; Autonomously Replicating Sequence" /db_xref="SGD:S000119040" gene complement(565787..566671) /gene="HAL1" /locus_tag="YPR005C" mRNA complement(565787..566671) /gene="HAL1" /locus_tag="YPR005C" /product="Hal1p" CDS complement(565787..566671) /gene="HAL1" /locus_tag="YPR005C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:1505513]" /experiment="EXISTENCE:mutant phenotype:GO:0009651 response to salt stress [PMID:1505513]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:1505513]" /note="Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p" /codon_start=1 /product="Hal1p" /protein_id="DAA11432.1" /db_xref="SGD:S000006209" /translation="MHFKDLGLHDYTLKNLMYENNCCKFYDAVDENNISYVLKFVPSD VTSEGDTFPFVDRFQVKEGVFLVYSSNDFGKEGTDYFTYTGSGGNEVHISGTSSEAGI KPQFIETCHPKHLKRGTKEQEDINSSTSKKSAVINNFSGEKTPNPRPQSSNISERETY VGILNVKCKNKNSSKIRSEKLVSSVIETKHTPGLASILSKEGTTYPNNADGKHISIVN PSSKIYHSSHKQIVKTPIPKSGLSPIERCPFNGQNIKCYSPRPLDHESPQRDFNNNFQ LRILKSSVLQRRQSTQNS" gene complement(567269..568996) /gene="ICL2" /locus_tag="YPR006C" mRNA complement(567269..568996) /gene="ICL2" /locus_tag="YPR006C" /product="methylisocitrate lyase ICL2" CDS complement(567269..568996) /gene="ICL2" /locus_tag="YPR006C" /EC_number="4.1.3.30" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:11092862]" /experiment="EXISTENCE:direct assay:GO:0019629 propionate catabolic process, 2-methylcitrate cycle [PMID:11092862]" /experiment="EXISTENCE:direct assay:GO:0046421 methylisocitrate lyase activity [PMID:11092862]" /note="2-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol" /codon_start=1 /product="methylisocitrate lyase ICL2" /protein_id="DAA11433.1" /db_xref="SGD:S000006210" /translation="MITMINNKTFNRKTTGTLKKLVLSSDKSLRRSFNGASSTKDFVF SESSKVEEWWESARFKNISRPYSATDVVKHRGSLPANTSIYPSSYQARKLFNLLEENF KNGTPLHTLGVIDPVQMSQLARCRNIKVAYISGWACSSTLVGSTNEVSPDFGDYPYDT VPNQVERIFKAQQLHDRKAFLEASIKGSTPVDYLKPIIADADMGHGGPTTVMKVAKLF AEKGAAGIHLEDQMVGGKRCGHLSGAVLVPTATHLMRLISTRFQWDIMGTENLVIART DSCNGKLLSSSSDPRDHEFIRGIIRDNVVPWSEKLIEMEDKKIPNSAIADMEKEWYHE NELFTFEEALEKQFTASEFESYKEKKEDLMVNKLGRAYLSLREMKLLAQEVTPLKKII FDWDAPRTKEGYYMFNGCIEAAIRRSLVFAPYSDMIWLETKTPDLEQARSFSRKIHKQ LPATKLVYNLSPSFNWSAHGFDDKALKSFVWDLAKEGFTLQLVSLAGLHSDGVSFWEL ANSFQSDGMKAYVEKVQKREKETNCDIMTHQLWSGAEYVDSLMKVVQNGASSQTLSTS GESFTETQF" gene complement(569336..571378) /gene="REC8" /locus_tag="YPR007C" /gene_synonym="SPO69" mRNA complement(569336..571378) /gene="REC8" /locus_tag="YPR007C" /gene_synonym="SPO69" /product="Rec8p" CDS complement(569336..571378) /gene="REC8" /locus_tag="YPR007C" /gene_synonym="SPO69" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:23246437]" /experiment="EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:10412984|PMID:16357219]" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:16357219]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:23246437]" /experiment="EXISTENCE:genetic interaction:GO:0071459 protein localization to chromosome, centromeric region [PMID:16357219]" /experiment="EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:10412984]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10412984]" /experiment="EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:31617566]" /experiment="EXISTENCE:mutant phenotype:GO:0051177 meiotic sister chromatid cohesion [PMID:10412984]" /note="Meiosis-specific component of the sister chromatid cohesion complex; alpha-kleisin family member that maintains cohesion between homologous chromosomes during meiosis I until chromosome arm-associated Rec8p is cleaved by Esp1p; cohesion between sister chromatid centromeres is maintained until metaphase of meiosis II when it is cleaved by Esp1; independent of the role in cohesion, Rec8p promotes allelic collisions and prevents nonspecific chromosome interactions; homolog of S. pombe Rec8p" /codon_start=1 /product="Rec8p" /protein_id="DAA11434.1" /db_xref="SGD:S000006211" /translation="MAPLSLNFKDDKKYKGLTTVWLLSALGNSIVKESNNYYSNKSNS TGNISSSTVKKKDIVNISIPKTCDEIQNFENDFSLRYISNLLYGVTICYNKKTEYVLN DLNHLLVQLQKNDVYAFKAKNKSTRINGLNSNNSIIGNKNNNYTWEECVFFDDDPLYD ITKVPALEFLNTTLQDNVSFIEEAKSIRRQDYINELSNSNRFELHGDMTNSDAQSNLG SNVRNSFPLDEIPVDVDFNLDLDDIVSHQGTPLGSHSSSQKDGNDFKFNYQGDELVLN FENDNENNSNGGEDTSVENEGPVANLKDYELGLEAQASEEENDLQQKLNTRMQRGHRA DVGGQFSKVQFDAKTSYPNEVLKFNHGNYSHLMEKNRIRKLTGQNFLTSNISSLVRSC GEEEFFSTNWLSIFNDFSNIKTSEWDLYPQGFSSVERGRKRAHSLVSTQSSSSTRSHE YGRKSFRNNKNDNYSSDMENDNLLLNLEQINEDLEDGHYIEENSQGNILDFNLNLPPS SFGRSHTRNSTRSSGFNEDIVGALRRRVGPSEQNFAEEDDSSNSCFSDGSQQNLQQDK TNFQDVILDYQTKKFYDYIKERSIVVGRTTRSNPPFKRKMLLVDIIPSRMGEAQTGAN FDDVERGVSRQIAASAFLSLLNLATKGMVKLNEYPVADAVTKDLKLRREDEIIVYA" repeat_region complement(571845..572173) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007200" gene 572269..572339 /locus_tag="YNCP0009W" tRNA 572269..572339 /locus_tag="YNCP0009W" /product="tRNA-Gly" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /experiment="EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]" /experiment="EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]" /note="Glycine tRNA (tRNA-Gly), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006588" gene 573018..575102 /gene="HAA1" /locus_tag="YPR008W" mRNA 573018..575102 /gene="HAA1" /locus_tag="YPR008W" /product="Haa1p" CDS 573018..575102 /gene="HAA1" /locus_tag="YPR008W" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:21586585]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11504737]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11504737]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:16176797]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16176797|PMID:16980434|PMID:28068993|PMID:11504737]" /experiment="EXISTENCE:mutant phenotype:GO:0071468 cellular response to acidic pH [PMID:28068993|PMID:16980434]" /note="Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress" /codon_start=1 /product="Haa1p" /protein_id="DAA11435.1" /db_xref="SGD:S000006212" /translation="MVLINGIKYACERCIRGHRVTTCNHTDQPLMMIKPKGRPSTTCD YCKQLRKNKNANPEGVCTCGRLEKKKLAQKAKEEARAKAKEKQRKQCTCGTDEVCKYH AQKRHLRKSPSSSQKKGRSISRSQPMFERVLSSTSLDSNMLSGHGALSDTSSILTSTF LDSEPGVGKISKDYHHVPSLASISSLQSSQSLDQNFSIPQSPPLSSMSFNFLTGNINE TNQNHSNHQHSKSGNNWQDSSVSLPAKADSRLNMMDKNNSVGLDLLGHSKRISPISNS RVGEVSVPLEEYIPSDIDGVGRVTDKSSLVYDWPFDESIERNFSTTATAATGESKFDI NDNCNRINSKSYSKTNSMNGNGMNNSNNNNINSNGNDKNNNNSSRQEHQGNGLFDMFT DSSSISTLSRANLLLQEKIGSQENSVKQENYSKNPQLRHQLTSRSRSFIHHPANEYLK NTFGNSHSNDIGKGVEVLSLTPSFMDIPEKERETERSPSSNYITDRPFTRKPRSSSID VNHRYPPMAPTTVATSPGALNNAVASNLDDQLSLTSLNSQPSSIANMMMDPSNLAEQS SIHSVPQSINSPRMPKTGSRQDKNIHTKKEERNPLNNIHDLSQLENVPDEMNQMFSPP LKSMNRPDAIRENSSSSNFIIQGNSMISTPSGRNDLPDTSPMSSIQTASPPSQLLTDQ GFADLDNFMSSL" gene 576552..577358 /gene="SUT2" /locus_tag="YPR009W" mRNA 576552..577358 /gene="SUT2" /locus_tag="YPR009W" /product="Sut2p" CDS 576552..577358 /gene="SUT2" /locus_tag="YPR009W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15030478]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:23872066]" /experiment="EXISTENCE:genetic interaction:GO:1900237 positive regulation of induction of conjugation with cellular fusion [PMID:23872066]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:26448198|PMID:23872066]" /experiment="EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:26448198]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11248676]" /experiment="EXISTENCE:mutant phenotype:GO:1900237 positive regulation of induction of conjugation with cellular fusion [PMID:23872066]" /experiment="EXISTENCE:mutant phenotype:GO:1900429 negative regulation of filamentous growth of a population of unicellular organisms [PMID:26448198]" /experiment="EXISTENCE:mutant phenotype:GO:2000911 positive regulation of sterol import [PMID:11248676]" /note="Zn2Cys6 family transcription factor; positively regulates sterol uptake under anaerobic conditions with SUT1; represses filamentation-inducing genes during non-starvation conditions; positively regulates mating along with SUT1 by repressing the expression of genes (PRR2, NCE102 and RHO5) which function as mating inhibitors; multicopy suppressor of mutations that cause low activity of the cAMP/PKA pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication" /codon_start=1 /product="Sut2p" /protein_id="DAA11436.1" /db_xref="SGD:S000006213" /translation="MKPNNRTCDVITNKDESLPALLLPALNSYTCDDSLLKGQISSNG RYQPFGFSDCSLLPKRLNIQAGQGSMPVSSIQCADHSYSNWQKESEKTKLPKLGCPTE YTEYYKTVSSGETTDSAVVSSIATNRLKRKRQRDGPSCDSCRIKKIKCNATIIIFLQD RNLISSISSNLHYTLSQDDINQFRMKFFRKLPDVMGTYEVIKHLDKIVLFKACTSCSR RNQKNGKCLFSRGFTKSDMNVFPKINSKLKDKSIFEMTVDDYVAAGFQTL" gene complement(577585..581196) /gene="RPA135" /locus_tag="YPR010C" /gene_synonym="RPA2" /gene_synonym="RRN2" /gene_synonym="SRP3" mRNA complement(577585..581196) /gene="RPA135" /locus_tag="YPR010C" /gene_synonym="RPA2" /gene_synonym="RRN2" /gene_synonym="SRP3" /product="DNA-directed RNA polymerase I core subunit RPA135" CDS complement(577585..581196) /gene="RPA135" /locus_tag="YPR010C" /gene_synonym="RPA2" /gene_synonym="RRN2" /gene_synonym="SRP3" /EC_number="2.7.7.6" /experiment="EXISTENCE:direct assay:GO:0001054 RNA polymerase I activity [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:genetic interaction:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:2023944]" /note="RNA polymerase I second largest subunit A135" /codon_start=1 /product="DNA-directed RNA polymerase I core subunit RPA135" /protein_id="DAA11437.1" /db_xref="SGD:S000006214" /translation="MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQP HIGSFNALTEGPDGGLLNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQV SIAKPMSNDGVSSAVERKVYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGG LPVMLQSNRCHLNKMSPYELVQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAII RPSFANRGASYSHYGIQIRSVRPDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMI LKALCHTSDREIFDGIIGNDVKDSFLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKF RVVFQASPDQSDLEVGQEVLDRIVLVHLGKDGSQDKFRMLLFMIRKLYSLVAGECSPD NPDATQHQEVLLGGFLYGMILKEKIDEYLQNIIAQVRMDINRGMAINFKDKRYMSRVL MRVNENIGSKMQYFLSTGNLVSQSGLDLQQVSGYTVVAEKINFYRFISHFRMVHRGSF FAQLKTTTVRKLLPESWGFLCPVHTPDGSPCGLLNHFAHKCRISTQQSDVSRIPSILY SLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQGKIIADTLRYWKVEGKTPGLPIDL EIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDKEDIVGPFEQVYMNIAVTPQEIQ NNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQMGKQTMGTPGVALCHRSDNK LYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTGYDMDDAMIINKSADERGF GYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKLDEDGLPYIGTYVEEGD PICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQTVSIKYRIRRTPQIG DKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTIGMFVESLAGKAG ALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGEELRADIYVGV VYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALIGHGTSFLL QDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKKLLTKSE DGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNVEPK" gene 582062..582134 /locus_tag="YNCP0010W" tRNA 582062..582134 /locus_tag="YNCP0010W" /product="tRNA-Lys" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:8915539]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:8915539]" /experiment="EXISTENCE:mutant phenotype:GO:0030533 triplet codon-amino acid adaptor activity [PMID:17560369]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:17560369]" /note="Lysine tRNA (tRNA-Lys), predicted by tRNAscan-SE analysis; a small portion is imported into mitochondria via interaction with mt lysyl-tRNA synthetase Msk1p and is necessary to decode AAG codons at high temperature, when base modification of mt-encoded tRNA-Lys is reduced" /db_xref="SGD:S000006628" gene complement(582373..582734) /gene="MRA1" /locus_tag="YPR010C-A" /gene_synonym="MIN8" mRNA complement(join(582373..582558,582702..582734)) /gene="MRA1" /locus_tag="YPR010C-A" /gene_synonym="MIN8" /product="Mra1p" CDS complement(join(582373..582558,582702..582734)) /gene="MRA1" /locus_tag="YPR010C-A" /gene_synonym="MIN8" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0031333 negative regulation of protein-containing complex assembly [PMID:38508182]" /note="Protein that negatively regulates respiratory complex assembly; associated with the inner mitochondrial membrane; antagonistic with Rcf2p to control ETC assembly; conserved among Saccharomyces sensu stricto species" /codon_start=1 /product="Mra1p" /protein_id="DAA11438.1" /db_xref="SGD:S000122558" /translation="MRPAQLLLNTAKKTSGGYKIPVELTPLFLAVGVALCSGTYFTYK KLRTDETLRLTGNPELSSLDEVLAKDKD" gene complement(583062..584042) /gene="MRX21" /locus_tag="YPR011C" mRNA complement(583062..584042) /gene="MRX21" /locus_tag="YPR011C" /product="Mrx21p" CDS complement(583062..584042) /gene="MRX21" /locus_tag="YPR011C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [PMID:24296033]" /experiment="EXISTENCE:direct assay:GO:1902557 5'-adenylyl sulfate transmembrane transporter activity [PMID:24296033]" /experiment="EXISTENCE:direct assay:GO:1902558 5'-adenylyl sulfate transmembrane transport [PMID:24296033]" /experiment="EXISTENCE:direct assay:GO:1902559 3'-phospho-5'-adenylyl sulfate transmembrane transport [PMID:24296033]" /note="Mitochondrial transporter; major substrates are adenosine 5'-phosphosulfate (APS) and 3'-phospho-adenosine 5'-phosphosulfate (PAPS); member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /codon_start=1 /product="Mrx21p" /protein_id="DAA11439.1" /db_xref="SGD:S000006215" /translation="MAEVLTVLEQPNSIKDFLKQDSNIAFLAGGVAGAVSRTVVSPFE RVKILLQVQSSTTSYNRGIFSSIRQVYHEEGTKGLFRGNGLNCIRIFPYSAVQFVVYE ACKKKLFHVNGNNGQEQLTNTQRLFSGALCGGCSVVATYPLDLIKTRLSIQTANLSSL NRSKAKSISKPPGIWQLLSETYRLEGGLRGLYRGVWPTSLGVVPYVALNFAVYEQLRE FGVNSSDAQPSWKSNLYKLTIGAISGGVAQTITYPFDLLRRRFQVLAMGGNELGFRYT SVWDALVTIGRAEGVSGYYKGLAANLFKVVPSTAVSWLVYEVVCDSVRNW" gene complement(584632..585585) /gene="CMR3" /locus_tag="YPR013C" mRNA complement(584632..585585) /gene="CMR3" /locus_tag="YPR013C" /product="Cmr3p" CDS complement(584632..585585) /gene="CMR3" /locus_tag="YPR013C" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:23012409]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /note="Putative zinc finger protein; YPR013C is not an essential gene" /codon_start=1 /product="Cmr3p" /protein_id="DAA11440.1" /db_xref="SGD:S000006217" /translation="MNFSLSKQSSEKQSSYTDKSRSPNIGMCTVNYKSNLPLQVSAVD QLSTGKGTQFYGHNSYKNERECYNSTKINLPPISSLLPNFENNTPPNVDSRVQFPPQQ VYQSMNVVPIVNEIYTPISMNATSDQYPIYYTESQQPIPHSQSPHLTSSAPLMMPVMV PTVYKPLTPYDKEPITIASEPNFTAISMASHPNAALELCHDRPKSVPPGYGVLPTMQE ASNGRTKSEPGAVLNGSATFSDWKTDTRISSTKLRKQCPVCGKICSRPSTLKTHYLIH TGDTPFKCTWEGCTKSFNVKSNMLRHLKSHERKRNKVLNTT" gene complement(587189..587518) /locus_tag="YPR014C" mRNA complement(587189..587518) /locus_tag="YPR014C" /product="hypothetical protein" CDS complement(587189..587518) /locus_tag="YPR014C" /note="hypothetical protein; conserved across S. cerevisiae strains; YPR014C is not an essential gene" /codon_start=1 /product="hypothetical protein" /protein_id="DAA80344.1" /db_xref="SGD:S000006218" /translation="MSCIFSADLGVEYSCAESRITNLVLCILCIREEKAAPVVKKDKF LFFIFLSSKENLFCEISSRSSVSEVKSLRAKNNFICPHAVIGFQGAKAQLGIRFPQLN GLLRLQH" gene 588998..589830 /gene="SUT418" /locus_tag="YNCP0026W" ncRNA 588998..589830 /ncRNA_class="other" /gene="SUT418" /locus_tag="YNCP0026W" /product="SUT418" /note="Stable Unannotated Transcript functional ncRNA; improves endogenous invertase secretion when deleted" /db_xref="SGD:S000345044" gene complement(590283..591026) /locus_tag="YPR015C" mRNA complement(590283..591026) /locus_tag="YPR015C" /product="hypothetical protein" CDS complement(590283..591026) /locus_tag="YPR015C" /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:18617996]" /note="Putative zinc finger transcription factor; binds DNA in sequence-specific manner; overexpression causes a cell cycle delay or arrest" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11441.1" /db_xref="SGD:S000006219" /translation="MWRTKTLESMLCSPMKCSSSNIGGSYAQSSKEVSNTTKREVHLP PCSSIMHAPLTPEINQAALPPPAYHYAPSSLHQTEDPVWRSSPNSIIFSPVIATPQPF PLTFVERQSCCPIYSTAASSYTAQSVPPSMQHFQEENHRAVSNEQYSLPNVHIGQNPG TLLSQTQTDLDLIQKQLRAVVKLRKQCPICGKVCSRPSTLRTHYLIHTGDTPFKCTWE HCNKSFNVKSNMLRHLRTHQKKIAKKKHQ" gene complement(592332..593069) /gene="TIF6" /locus_tag="YPR016C" /gene_synonym="CDC95" mRNA complement(592332..593069) /gene="TIF6" /locus_tag="YPR016C" /gene_synonym="CDC95" /product="translation initiation factor 6" CDS complement(592332..593069) /gene="TIF6" /locus_tag="YPR016C" /gene_synonym="CDC95" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11238882]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:17353896]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11238882]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:23212245|PMID:16188229|PMID:17443350]" /experiment="EXISTENCE:direct assay:GO:0043023 ribosomal large subunit binding [PMID:9891075]" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:17353896]" /experiment="EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:17353896]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11238882]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11238882]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11238882|PMID:10206977]" /experiment="EXISTENCE:mutant phenotype:GO:1902626 assembly of large subunit precursor of preribosome [PMID:22735702]" /note="Constituent of 66S pre-ribosomal particles; has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits" /codon_start=1 /product="translation initiation factor 6" /protein_id="DAA11442.1" /db_xref="SGD:S000006220" /translation="MATRTQFENSNEIGVFSKLTNTYCLVAVGGSENFYSAFEAELGD AIPIVHTTIAGTRIIGRMTAGNRRGLLVPTQTTDQELQHLRNSLPDSVKIQRVEERLS ALGNVICCNDYVALVHPDIDRETEELISDVLGVEVFRQTISGNILVGSYCSLSNQGGL VHPQTSVQDQEELSSLLQVPLVAGTVNRGSSVVGAGMVVNDYLAVTGLDTTAPELSVI ESIFRLQDAQPESISGNLRDTLIETYS" gene complement(593486..593917) /gene="DSS4" /locus_tag="YPR017C" mRNA complement(593486..593917) /gene="DSS4" /locus_tag="YPR017C" /product="guanine nucleotide exchange factor DSS4" CDS complement(593486..593917) /gene="DSS4" /locus_tag="YPR017C" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:9218467]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:9218467]" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:9218467]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:9218467]" /experiment="EXISTENCE:genetic interaction:GO:0006892 post-Golgi vesicle-mediated transport [PMID:9218467|PMID:8429886]" /experiment="EXISTENCE:mutant phenotype:GO:0006892 post-Golgi vesicle-mediated transport [PMID:9218467|PMID:8429886]" /experiment="EXISTENCE:physical interaction:GO:0006892 post-Golgi vesicle-mediated transport [PMID:9218467]" /note="Guanine nucleotide dissociation stimulator for Sec4p; functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol" /codon_start=1 /product="guanine nucleotide exchange factor DSS4" /protein_id="DAA11443.1" /db_xref="SGD:S000006221" /translation="MSKATCSFEGCHSAVITINDDNIINLPEQVHSEFKLLENRTMRD ATPSESNFLVVPDVWDFDNVGVSREIPSSILGDLSDKSDFVFEYGNSSWKIKKCLKYL ICADCDKGPIGIICKVQDQTKNEERVLHLLSLRSLQIMGRN" gene 594476..596296 /gene="RLF2" /locus_tag="YPR018W" /gene_synonym="CAC1" mRNA 594476..596296 /gene="RLF2" /locus_tag="YPR018W" /gene_synonym="CAC1" /product="Rlf2p" CDS 594476..596296 /gene="RLF2" /locus_tag="YPR018W" /gene_synonym="CAC1" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:11782447]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:25602519]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9030688]" /experiment="EXISTENCE:direct assay:GO:0006335 DNA replication-dependent chromatin assembly [PMID:9030687]" /experiment="EXISTENCE:direct assay:GO:0033186 CAF-1 complex [PMID:9030687]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:16503640]" /experiment="EXISTENCE:mutant phenotype:GO:0006335 DNA replication-dependent chromatin assembly [PMID:9030688]" /note="Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including histone H3/H4 tetramerization, silencing at telomeres, mating type loci and rDNA, maintenance of kinetochore structure, deactivation of DNA damage checkpoint after DNA repair, chromatin dynamics during transcription, and repression of divergent noncoding transcription" /codon_start=1 /product="Rlf2p" /protein_id="DAA11444.1" /db_xref="SGD:S000006222" /translation="MEQHLKSIPLQDDTKKKGILSFFQNTTTVKSNKFLTKEKDVITL DDPKEDVSGPMIETVKQETMKSINKECADEMKTTPKKANAEDKLLCYKNSPIQSTKYD RNTNKQVPNGNIIAIETKSRSSSPCSKRELSSSKKEEAKREKELKKQQRAEEKHRKEL LRQEEKKKKELKVEEERQRRAELKKQKEEEKRRKEEARLEAKRRKEEERLKKEEEIRL KEEAKERAQSRIGNFFKKLSDSNTPVVEKSDYEKFFLPFYAKDGVRVSNKWKLTKVEL EGSKRKIDDELLNSKDKTSSDDLLNWLQSRRLPRGHKIKRKAVDVLQQMPLKEKTDDE LQSLLAQVPHKYIKFYENVRPPFIGTYSMDFTLPPNDPFSTKGTGFNYDYDSDVEWVN EEEEGEVDNLESGEEEEEEEDDEDVPSEGEFDGFLDSEENSDLDGLPCAKRKFVGPLI PTICLKSNFENLSEENKRYLQQLKAEVIIETDGPIDPFKEPKTSSLPSKRSNSDLQAQ TASQSQSPEKKQKAMITDPMDLLRLFDGVQDSTFSLGTVTEIAQKNLPQYNKQTIKNT IKEYAIRSSGKGDLPRKWVIKDAQNWENLRANANMPTPSL" gene 596750..599551 /gene="MCM4" /locus_tag="YPR019W" /gene_synonym="CDC54" /gene_synonym="HCD21" mRNA 596750..599551 /gene="MCM4" /locus_tag="YPR019W" /gene_synonym="CDC54" /gene_synonym="HCD21" /product="MCM DNA helicase complex subunit MCM4" CDS 596750..599551 /gene="MCM4" /locus_tag="YPR019W" /gene_synonym="CDC54" /gene_synonym="HCD21" /EC_number="3.6.4.12" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:15723534]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194|PMID:11756674]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10704410|PMID:10559985]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:9335335|PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10559985|PMID:10704410]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0006268 DNA unwinding involved in DNA replication [PMID:15723534|PMID:13679365]" /experiment="EXISTENCE:direct assay:GO:0009378 four-way junction helicase activity [PMID:13679365]" /experiment="EXISTENCE:direct assay:GO:0017116 single-stranded DNA helicase activity [PMID:15723534|PMID:18657510]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]" /experiment="EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:16531994]" /experiment="EXISTENCE:direct assay:GO:0042555 MCM complex [PMID:12480933]" /experiment="EXISTENCE:direct assay:GO:0043138 3'-5' DNA helicase activity [PMID:13679365]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:16103218]" /experiment="EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]" /experiment="EXISTENCE:direct assay:GO:0097373 MCM core complex [PMID:13679365]" /experiment="EXISTENCE:genetic interaction:GO:0006270 DNA replication initiation [PMID:2044962]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0003697 single-stranded DNA binding [PMID:17895243]" /experiment="EXISTENCE:mutant phenotype:GO:0006271 DNA strand elongation involved in DNA replication [PMID:10834843]" /experiment="EXISTENCE:mutant phenotype:GO:0033260 nuclear DNA replication [PMID:2044962]" /note="Essential helicase component of heterohexameric MCM2-7 complexes; MCM2-7 complexes bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p" /codon_start=1 /product="MCM DNA helicase complex subunit MCM4" /protein_id="DAA11445.1" /db_xref="SGD:S000006223" /translation="MSQQSSSPTKEDNNSSSPVVPNPDSVPPQLSSPALFYSSSSSQG DIYGRNNSQNLSQGEGNIRAAIGSSPLNFPSSSQRQNSDVFQSQGRQGRIRSSASASG RSRYHSDLRSDRALPTSSSSLGRNGQNRVHMRRNDIHTSDLSSPRRIVDFDTRSGVNT LDTSSSSAPPSEASEPLRIIWGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINN TTDEELYYIKQLNEMRELGTSNLNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTI KDCMVSLIVDNNLDYDLDEIETKFYKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLR STPVIPDMKVAFFKCNVCDHTMAVEIDRGVIQEPARCERIDCNEPNSMSLIHNRCSFA DKQVIKLQETPDFVPDGQTPHSISLCVYDELVDSCRAGDRIEVTGTFRSIPIRANSRQ RVLKSLYKTYVDVVHVKKVSDKRLDVDTSTIEQELMQNKVDHNEVEEVRQITDQDLAK IREVAAREDLYSLLARSIAPSIYELEDVKKGILLQLFGGTNKTFTKGGRYRGDINILL CGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVGLTAYITRDVDTKQLVLESGALVLS DGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAGIITTLNARSSILASANPIGSRY NPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDRELAKHLTNLYLEDKPEHISQDD VLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKMGDDSRSDEKRITATTRQL ESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYATDPKTGKIDMNLVQTGKSV IQRKLQEDLSREIMNVLKDQASDSMSFNELIKQINEHSQDRVESSDIQEALSRLQQED KVIVLGEGVRRSVRLNNRV" gene 599870..600217 /gene="ATP20" /locus_tag="YPR020W" mRNA 599870..600217 /gene="ATP20" /locus_tag="YPR020W" /product="F1F0 ATP synthase subunit g" CDS 599870..600217 /gene="ATP20" /locus_tag="YPR020W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:20219971|PMID:17761666|PMID:16551625]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:10336613|PMID:9857174]" /experiment="EXISTENCE:mutant phenotype:GO:0042407 cristae formation [PMID:19528297]" /experiment="EXISTENCE:mutant phenotype:GO:0045259 proton-transporting ATP synthase complex [PMID:10336613]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:20219971|PMID:17761666|PMID:16551625]" /note="Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex, which in turn determines oligomerization of the complex and the shape of inner membrane cristae" /codon_start=1 /product="F1F0 ATP synthase subunit g" /protein_id="DAA11446.1" /db_xref="SGD:S000006224" /translation="MLSRIQNYTSGLVSKANLLSSKALYYGKVGAEISKQIYLKEGLQ PPTVAQFKSVYSNLYKQSLNFALKPTEVLSCLKNIQKNELLKYGAYGIQLIGFYSVGE IIGRRKLVGYKHH" gene complement(600649..603357) /gene="AGC1" /locus_tag="YPR021C" mRNA complement(600649..603357) /gene="AGC1" /locus_tag="YPR021C" /product="citrin" CDS complement(600649..603357) /gene="AGC1" /locus_tag="YPR021C" /experiment="EXISTENCE:direct assay:GO:0005313 L-glutamate transmembrane transporter activity [PMID:14622413]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0015183 L-aspartate transmembrane transporter activity [PMID:14622413]" /experiment="EXISTENCE:direct assay:GO:0015292 uniporter activity [PMID:14622413]" /experiment="EXISTENCE:direct assay:GO:0015297 antiporter activity [PMID:14622413]" /experiment="EXISTENCE:direct assay:GO:0015810 aspartate transmembrane transport [PMID:14622413]" /experiment="EXISTENCE:direct assay:GO:0015813 L-glutamate transmembrane transport [PMID:14622413]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]" /experiment="EXISTENCE:mutant phenotype:GO:0009058 biosynthetic process [PMID:14622413]" /note="Mitochondrial amino acid transporter; acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis; human homolog SLC25A13 complements yeast null mutant" /codon_start=1 /product="citrin" /protein_id="DAA11447.1" /db_xref="SGD:S000006225" /translation="MEQINSNSRKKKQQLEVFKYFASVLTKEDKPISISNGMLDMPTV NSSKLTAGNGKPDTEKLTGELILTYDDFIELISSSKTIYSKFTDHSFNLNQIPKNVFG CIFFAIDEQNKGYLTLNDWFYFNNLLEYDNYHLIILYEFFRKFDVENLKAKQKKELGS SSFNLKAADDRIKSINYGNRFLSFDDLLLNLNQFKDTIRLLHESIDDNFVKDNKLLLD WNDFRFLKFYKCYHENEEYLSLNSLVTILQNDLKNEKIFIGFDRLAQMDSQGHRLALS KNQLTYLLRLFYSHRVSADIFSSLNLSNTELLKADNNSIPYNVFKDIFYLFQNFDLLN QIFHKYVTENNLNEQDIREQIVTKNDFMTVLNAQYNKVNNIIEFSPSQINLLFSIVAN SKENRRLRKRNQDRDDELLNDHHYDSDIDFFIHNEYLHGVSRSRKNLESFNDYYHDLS DGFDQDSGVKKASKASTGLFESVFGGKKDKATMRSDLTIEDFMKILNPNYLNDLVHQM ELQKNQNESLYINYYFYPIFDSLYNFSLGSIAGCIGATVVYPIDFIKTRMQAQRSLAQ YKNSIDCLLKIISREGIKGLYSGLGPQLIGVAPEKAIKLTVNDFMRNRLTDKNGKLSL FPEIISGASAGACQVIFTNPLEIVKIRLQVQSDYVGENIQQANETATQIVKKLGLRGL YNGVAACLMRDVPFSAIYFPTYAHLKKDLFDFDPNDKTKRNRLKTWELLTAGAIAGMP AAFLTTPFDVIKTRLQIDPRKGETKYNGIFHAIRTILKEESFRSFFKGGGARVLRSSP QFGFTLAAYELFKGFIPSPDNKLKSREGRKRFCIDDDAGNEETVVHSNGELPQQKFYS DDRKHANYYYKSCQIAKTFIDLDNNFSRFDSSVYKNFQEHLRSING" gene complement(603911..607312) /gene="SDD4" /locus_tag="YPR022C" mRNA complement(603911..607312) /gene="SDD4" /locus_tag="YPR022C" /product="Sdd4p" CDS complement(603911..607312) /gene="SDD4" /locus_tag="YPR022C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /note="Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; overproduction of a truncation allele suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P" /codon_start=1 /product="Sdd4p" /protein_id="DAA11448.1" /db_xref="SGD:S000006226" /translation="MHGKELAGRLRKRENDNDLSPNSSSSPAERFRCPHPECNKTFSR QEHLSRHKLNHWPKEIYVCSYVLPTTNAPCNKTFVRKDLLIRHEKRHSKVKNRLSRPS KDQISSSNKDFSKNAPYNPSEVPLSTQSGTSTINLIKNSVNPPPSITQESKFRPFLQQ AQQPQQVQQSQQPQQIQQLQQLQFPQQLRAPLQQPMLQQQMHPQQASPTFPSYDPRIR NNGQNGNQFFNLIFDNRTGVNGFEVDAANNNGNGNDQNMNINPAVQQQRYQDRNFASS SYQQPLQPLTQDQQQEQYFQQQKLAQQQQQQQQQQQQQQQLPPQNPFGDPLTSSSSGA NLSVMQDLFSTNFLNSDPLQSFMQELSEAPQVSIEDTFSDKNTIPPNEKPVQQDEGFQ NPPVMFELPQDNIKIPKAQPKFNDNPSTSVKDNLSSQKLNINELKRRSSKDSGVGNNS SLNYKEQLRHSMKSVPSFFHPDPLTKYKISKEKCQEMFSFVPELRYVSIESIHKSLKS FWLNFHPQYGLLHKPSFHVDKQPAILNLALIMTGASFLGSEYREQISDPICGPLRWII FSHADFQPPSKTYIIQSLLLVEGYEKTSTNRYLHERSFLHHGTTIQLLRRTPSLGGHP LMVKTGKTSGENSIQDPQEVYKRWIDFEMLKRIAFYAFYMDTTHAVVFGYWNLFINSN QIQLTLPCPDQVWESYDLSYETLMEHGYGSTKRDENNTFLSALMQLMKNVIQILRNNN IRRNKVNNGGIESTPTDLESTTDWNIQSLFGKKILLAGIISILFQCQEEVNGDYFITN FRGGITDHLGLSWKDILSFAMNYWLHEVQKSCTDPKACRISTPSEETLTNRKIDEDNG DGLCDDDLDLLSSDNPSNCKIPVIHISQIVLRILHHDYYIYAGAPWRMNVPIGRDEYD MISRRILQFAKDPYNGGVAVVYAFQFLFEMFIIKENNVPTVVKSYNINSDPVITRPYA IALTSLLIWSCNFALHGCEVSIWDNTEASKDECFQPDDSNGGNILGNTDNNGSTIANN NLKEKNNYIPIESFEVYLLRMYRNLYVDSSLDVVSFQNDVWAKASLLQHISNTHFLCG MMQFMRDIFNKSYWDLGREFGKLFDNCLERSLGKTSPTCHNMFDV" gene complement(608826..610031) /gene="EAF3" /locus_tag="YPR023C" mRNA complement(608826..610031) /gene="EAF3" /locus_tag="YPR023C" /product="Eaf3p" CDS complement(608826..610031) /gene="EAF3" /locus_tag="YPR023C" /experiment="EXISTENCE:direct assay:GO:0000123 histone acetyltransferase complex [PMID:11036083]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]" /experiment="EXISTENCE:direct assay:GO:0032221 Rpd3S complex [PMID:16286008|PMID:16286007]" /experiment="EXISTENCE:direct assay:GO:0035064 methylated histone binding [PMID:16364921]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15485911]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:19948887]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11036083]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:19417103]" /experiment="EXISTENCE:mutant phenotype:GO:0043487 regulation of RNA stability [PMID:31694990]" /experiment="EXISTENCE:mutant phenotype:GO:0045892 negative regulation of DNA-templated transcription [PMID:16364921]" /experiment="EXISTENCE:mutant phenotype:GO:0060195 negative regulation of antisense RNA transcription [PMID:21248844]" /note="Component of the Rpd3S histone deacetylase complex; Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition" /codon_start=1 /product="Eaf3p" /protein_id="DAA11449.1" /db_xref="SGD:S000006227" /translation="MVDLEQEFALGGRCLAFHGPLMYEAKILKIWDPSSKMYTSIPND KPGGSSQATKEIKPQKLGEDESIPEEIINGKCFFIHYQGWKSSWDEWVGYDRIRAYNE ENIAMKKRLANEAKEAKKSLLEQQKKKKLSTSLGGPSNGGKRKGDSRSNASISKSTSQ SFLTSSVSGRKSGRSSANSLHPGSSLRSSSDQNGNDDRRRSSSLSPNMLHHIAGYPTP KISLQIPIKLKSVLVDDWEYVTKDKKICRLPADVTVEMVLNKYEHEVSQELESPGSQS QLSEYCAGLKLYFDKCLGNMLLYRLERLQYDELLKKSSKDQKPLVPIRIYGAIHLLRL ISVLPELISSTTMDLQSCQLLIKQTEDFLVWLLMHVDEYFNDKDPNRSDDALYVNTSS QYEGVALGM" gene 610481..612724 /gene="YME1" /locus_tag="YPR024W" /gene_synonym="OSD1" /gene_synonym="YTA11" mRNA 610481..612724 /gene="YME1" /locus_tag="YPR024W" /gene_synonym="OSD1" /gene_synonym="YTA11" /product="i-AAA protease YME1" CDS 610481..612724 /gene="YME1" /locus_tag="YPR024W" /gene_synonym="OSD1" /gene_synonym="YTA11" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11914276|PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:8688560]" /experiment="EXISTENCE:direct assay:GO:0031942 i-AAA complex [PMID:16267274]" /experiment="EXISTENCE:direct assay:GO:0045041 protein import into mitochondrial intermembrane space [PMID:16966379]" /experiment="EXISTENCE:genetic interaction:GO:0004176 ATP-dependent peptidase activity [PMID:8688560]" /experiment="EXISTENCE:mutant phenotype:GO:0004176 ATP-dependent peptidase activity [PMID:15772085]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:22993211]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:27398316]" /experiment="EXISTENCE:mutant phenotype:GO:0045041 protein import into mitochondrial intermembrane space [PMID:16966379]" /experiment="EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:16966379]" /experiment="EXISTENCE:mutant phenotype:GO:0141164 mitochondrial protein quality control [PMID:18843051]" /note="Catalytic subunit of i-AAA protease complex; complex is located in mitochondrial inner membrane; responsible for degradation of unfolded or misfolded mitochondrial gene products; serves as nonconventional translocation motor to pull PNPase into intermembrane space; also has role in intermembrane space protein folding; mutation causes elevated rate of mitochondrial turnover; human homolog YME1L1 can complement yeast null mutant" /codon_start=1 /product="i-AAA protease YME1" /protein_id="DAA11450.1" /db_xref="SGD:S000006228" /translation="MNVSKILVSPTVTTNVLRIFAPRLPQIGASLLVQKKWALRSKKF YRFYSEKNSGEMPPKKEADSSGKASNKSTISSIDNSQPPPPSNTNDKTKQANVAVSHA MLATREQEANKDLTSPDAQAAFYKLLLQSNYPQYVVSRFETPGIASSPECMELYMEAL QRIGRHSEADAVRQNLLTASSAGAVNPSLASSSSNQSGYHGNFPSMYSPLYGSRKEPL HVVVSESTFTVVSRWVKWLLVFGILTYSFSEGFKYITENTTLLKSSEVADKSVDVAKT NVKFDDVCGCDEARAELEEIVDFLKDPTKYESLGGKLPKGVLLTGPPGTGKTLLARAT AGEAGVDFFFMSGSEFDEVYVGVGAKRIRDLFAQARSRAPAIIFIDELDAIGGKRNPK DQAYAKQTLNQLLVELDGFSQTSGIIIIGATNFPEALDKALTRPGRFDKVVNVDLPDV RGRADILKHHMKKITLADNVDPTIIARGTPGLSGAELANLVNQAAVYACQKNAVSVDM SHFEWAKDKILMGAERKTMVLTDAARKATAFHEAGHAIMAKYTNGATPLYKATILPRG RALGITFQLPEMDKVDITKRECQARLDVCMGGKIAEELIYGKDNTTSGCGSDLQSATG TARAMVTQYGMSDDVGPVNLSENWESWSNKIRDIADNEVIELLKDSEERARRLLTKKN VELHRLAQGLIEYETLDAHEIEQVCKGEKLDKLKTSTNTVVEGPDSDERKDIGDDKPK IPTMLNA" gene complement(613377..614558) /gene="CCL1" /locus_tag="YPR025C" mRNA complement(613377..614558) /gene="CCL1" /locus_tag="YPR025C" /product="TFIIH complex kinase subunit CCL1" CDS complement(613377..614558) /gene="CCL1" /locus_tag="YPR025C" /experiment="EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0070985 transcription factor TFIIK complex [PMID:11839796|PMID:19818408]" /experiment="EXISTENCE:genetic interaction:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:8230216]" /experiment="EXISTENCE:mutant phenotype:GO:0010508 positive regulation of autophagy [PMID:26567215]" /note="Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p; regulates the activity of Kin28p, a TFIIH-associated carboxy-terminal domain (CTD) kinase that facilitates recruitment of mRNA 5'-capping and polyadenylation factors to the RNAPII holoenzyme complex, and has a minor role in RNAPII transcription; subunit of TFIIK, a TFIIH subassembly; human homolog CCNH allows growth of a yeast ccl1 temperature-sensitive mutant at restrictive temperature" /codon_start=1 /product="TFIIH complex kinase subunit CCL1" /protein_id="DAA11451.1" /db_xref="SGD:S000006229" /translation="MTDIQLNGKSTLDTPSATMSAKEKEAKLKSADENNKPPNYKRIS DDDLYRHSSQYRMWSYTKDQLQEKRVDTNARAIAYIEENLLKFREAHNLTEEEIKVLE AKAIPLTMEEELDLVNFYAKKVQVIAQHLNLPTEVVATAISFFRRFFLENSVMQIDPK SIVHTTIFLACKSENYFISVDSFAQKAKSTRDSVLKFEFKLLESLKFSLLNHHPYKPL HGFFLDIQNVLYGKVDLNYMGQIYDRCKKRITAALLTDVVYFYTPPQITLATLLIEDE ALVTRYLETKFPSREGSQESVPGNEKEEPQNDASTTEKNKEKSTESEEYSIDSAKLLT IIRECKSIIEDCKPPSTEEAKKIAAKNYYCQNPSTLIQKLKRKLNGEDTSSTVEKKQK T" gene 615379..619014 /gene="ATH1" /locus_tag="YPR026W" mRNA 615379..619014 /gene="ATH1" /locus_tag="YPR026W" /product="alpha,alpha-trehalase ATH1" CDS 615379..619014 /gene="ATH1" /locus_tag="YPR026W" /EC_number="3.2.1.28" /experiment="EXISTENCE:direct assay:GO:0005993 trehalose catabolic process [PMID:8764988]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:15128531]" /experiment="EXISTENCE:direct assay:GO:0030287 cell wall-bounded periplasmic space [PMID:15128531]" /experiment="EXISTENCE:mutant phenotype:GO:0000324 fungal-type vacuole [PMID:7502577]" /experiment="EXISTENCE:mutant phenotype:GO:0004555 alpha,alpha-trehalase activity [PMID:7502577]" /experiment="EXISTENCE:mutant phenotype:GO:0005993 trehalose catabolic process [PMID:7502577|PMID:8764988]" /experiment="EXISTENCE:mutant phenotype:GO:0015771 trehalose transport [PMID:19016884]" /note="Acid trehalase required for utilization of extracellular trehalose; involved in intracellular trehalose degradation during growth recovery after saline stress" /codon_start=1 /product="alpha,alpha-trehalase ATH1" /protein_id="DAA11452.1" /db_xref="SGD:S000006230" /translation="MKRIRSLWFNAEASYSNLNNSPSLRNKNSTGNNSRSKNYRSFSR FDLINSILLLMMLFLLAIFVTALYLTKSSRLTYSHASRAALFNPLGVISPSLGNHTLN YDPEARESSKKLYELLSDFNTAYYDDENMILGSNLFSKNTYSRQPYVANGYIGSRIPN IGFGYALDTLNFYTDAPGALNNGWPLRNHRFAGAFVSDFYCLQPKLNSTNFPELDDVG YSTVISSIPQWTNLQFSLVNDSKWFNPQNVTLDDVTNYSQNLSMKDGIVTTELDWLNS QIHVKSEIWAHRHIHPLGVVSLEISLNTDHLPSDFDSLDVNIWDILDFNTSHRTVLHS TGTDEKNNAVFMIVQPDNVPSSNCAIYSTCTVKYENSTNPINSSESFEEKDVSSNIYN VILTEDQPKIIVHKYVGIMSTEFNKNKEQQDNTNIGLAKMIALNSKGNYEKLLSSHKR AWYDLYNDAFIEIPSDSLLEMTARSSLFHLLANTRDYNVSSDRGLPVGVSGLSSDSYG GMVFWDADIWMEPALLPFFPNVAQNMNNYRNATHSQAKLNAEKYGYPGAIYPWTSGKY ANCTSTGPCVDYEYHINVDVAMASFSIYLNGHEGIDDEYLRYTTWPIIKNAAQFFTAY VKYNSSLGLYETYNLTDPDEFANHINNGAFTNAGIKTLLKWATDIGNHLGEVVDPKWS EISKDIYIPRSSSNITLEYSGMNSSVEIKQADVTLMVYPLGYINDESILNNAIKDLYY YSERQSASGPAMTYPVFVAAAAGLLNHGSSSQSYLYKSVLPYLRAPFAQFSEQSDDNF LTNGLTQPAFPFLTANGGFLQSILFGLTGIRYSYEVDPDTKKINRLLRFNPIELPLLP GGIAIRNFKYMNQVLDIIIDDHNGTIVHKSGDVPIHIKIPNRSLIHDQDINFYNGSEN ERKPNLERRDVDRVGDPMRMDRYGTYYLLKPKQELTVQLFKPGLNARNNIAENKQITN LTAGVPGDVAFSALDGNNYTHWQPLDKIHRAKLLIDLGEYNEKEITKGMILWGQRPAK NISISILPHSEKVENLFANVTEIMQNSGNDQLLNETIGQLLDNAGIPVENVIDFDGIE QEDDESLDDVQALLHWKKEDLAKLIEQIPRLNFLKRKFVKILDNVPVSPSEPYYEASR NQSLIEILPSNRTTFTIDYDKLQVGDKGNTDWRKTRYIVVAVQGVYDDYDDDNKGATI KEIVLND" gene complement(620425..621258) /locus_tag="YPR027C" mRNA complement(620425..621258) /locus_tag="YPR027C" /product="hypothetical protein" CDS complement(620425..621258) /locus_tag="YPR027C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum, while the mCherry fusion protein localizes to the vacuole" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11453.1" /db_xref="SGD:S000006231" /translation="MVGIYRILASFVPLLGLLFAFHDDDMIDTVTIIKTVYETVTSTS TAPAPAATKSVSEKKLDDTKLTLQVIQTMVSCFSVGENPANMISCGLGVVILMFSLII ELINKLENDGINEPQRLYDLIKPKYVELPSNYVNEKIKTTFEPLDLYLGVNMNTSGSE LNQNCLILKLGEKTALPFPGLAQQICYTKGASNEFTNYKLSDIQGNLNENSQGIANGV FQKISNIRKISGNFKSQLYQISEKITDENWDGSAVGFTAHGREKGPNKSQISVSFYRD N" gene complement(622540..622631) /locus_tag="YNCP0011C" tRNA complement(join(622540..622575,622595..622631)) /locus_tag="YNCP0011C" /product="tRNA-Phe" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:10024171]" /note="Phenylalanine tRNA (tRNA-Phe), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006571" gene 623527..624202 /gene="YOP1" /locus_tag="YPR028W" /gene_synonym="YIP2" mRNA join(623527..623577,623711..624202) /gene="YOP1" /locus_tag="YPR028W" /gene_synonym="YIP2" /product="Yop1p" CDS join(623527..623577,623711..624202) /gene="YOP1" /locus_tag="YPR028W" /gene_synonym="YIP2" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16469703|PMID:22842922|PMID:26928762|PMID:27831485]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:11278413]" /experiment="EXISTENCE:direct assay:GO:0071782 endoplasmic reticulum tubular network [PMID:16469703]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0007029 endoplasmic reticulum organization [PMID:19665976]" /experiment="EXISTENCE:genetic interaction:GO:0032581 ER-dependent peroxisome organization [PMID:27129769]" /experiment="EXISTENCE:genetic interaction:GO:0034976 response to endoplasmic reticulum stress [PMID:27117666]" /experiment="EXISTENCE:genetic interaction:GO:0048309 endoplasmic reticulum inheritance [PMID:27117666]" /experiment="EXISTENCE:genetic interaction:GO:0051292 nuclear pore complex assembly [PMID:19273614]" /experiment="EXISTENCE:genetic interaction:GO:0071786 endoplasmic reticulum tubular network organization [PMID:18309084|PMID:16469703|PMID:18442980]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:11278413|PMID:12427979]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:11278413]" /note="Reticulon-interacting protein; ER integral membrane protein involved in the generation of tubular ER morphology; promotes membrane curvature; forms tubules in vitro; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; interacts with Yip1p to mediate membrane traffic and with Sey1p to maintain ER morphology; facilitates lipid exchange between the ER and mitochondria; forms ER foci upon DNA replication stress" /codon_start=1 /product="Yop1p" /protein_id="DAA11454.1" /db_xref="SGD:S000006232" /translation="MSEYASSIHSQMKQFDTKYSGNRILQQLENKTNLPKSYLVAGLG FAYLLLIFINVGGVGEILSNFAGFVLPAYLSLVALKTPTSTDDTQLLTYWIVFSFLSV IEFWSKAILYLIPFYWFLKTVFLIYIALPQTGGARMIYQKIVAPLTDRYILRDVSKTE KDEIRASVNEASKATGASVH" gene complement(624469..626967) /gene="APL4" /locus_tag="YPR029C" mRNA complement(624469..626967) /gene="APL4" /locus_tag="YPR029C" /product="Apl4p" CDS complement(624469..626967) /gene="APL4" /locus_tag="YPR029C" /experiment="EXISTENCE:direct assay:GO:0030121 AP-1 adaptor complex [PMID:10564262]" /experiment="EXISTENCE:direct assay:GO:0030276 clathrin binding [PMID:11489214]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:17003107]" /note="Gamma-adaptin; large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport" /codon_start=1 /product="AP-1 complex subunit gamma" /protein_id="DAA11455.1" /db_xref="SGD:S000006233" /translation="MGSSLRSFIKDVRGAKTLADERAIITKQSAKIRTKLRDDHLPHE KRRVNIQKLLYLYILGEKTHFGQVESINLIASDDFVDKRLGYLAATLLLDESEDLLTL LTNMLNNDLHHPNKYAVSLALTSLGFLSSPELARDLYPDVENIIKNSRDPFLLKKALQ CAAKLIFKDVSLLEIFNIEDITKILSSHSICTHGVLLGVTKIIQSILLIGLNRKKDED EDEDGIDYSNDILSPLSLLLRDFFIRLENMNSKNIEPGYDVQGICDPFLQCEIIYTLK LYFQVGELLNSNNVLDYKDNFCDLLTRIATNTDSTKNSGQAILYETVKTIFSLDLNQP LRVLGINILAKFLAGKDNNTKYVSLNTLLKVVPQEPTAVQRHRKFISHCLQDTDVSIR MRALELSFAILDDSNLVELVNELMKFLAKQDEDSKDLIIYTIDHLIDTFDTRVVKDES WKLDVFFNILKLVGSFINYEKINDILIIINNTSQLSDKSEFLRKMLTISLNGTSAEIS EENIGWQLVLIWCIGEYGDLVLNEGNKNGADIINESSITDYLLTLQELYTATNLKIIN YILTAALKLSVRFHDAKNIEKLRQLILSYTDSTDLSLQMKSNQYEIFFNQSISVKKII LETMPKFEKITEEQDNGKALSKNLISNEPVDLLSDLLGEDSKAESKASTGDNVKPIDI LEEIFGEKNDIAQVPKNANKEESINHSSAVEANSGVTLPLDANKIYDSSSLNVYASLL SANSGLAHLDLYFQAKSLISDLKTFCAVPKAQKLTLGQLYPSSTINASQICKQSLKIS GSGKLKLRVKLDFHLNGSSSITNEQFDHKFDETL" gene 627880..631245 /gene="CSR2" /locus_tag="YPR030W" /gene_synonym="ART8" /gene_synonym="MRG19" mRNA 627880..631245 /gene="CSR2" /locus_tag="YPR030W" /gene_synonym="ART8" /gene_synonym="MRG19" /product="Csr2p" CDS 627880..631245 /gene="CSR2" /locus_tag="YPR030W" /gene_synonym="ART8" /gene_synonym="MRG19" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12444972]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:12444972]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:10679005]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:12444972]" /experiment="EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:18976803]" /note="Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication" /codon_start=1 /product="Csr2p" /protein_id="DAA11456.1" /db_xref="SGD:S000006234" /translation="MQSTVPIAIASNGNKRDVVQNVSAGDEGDILQRLARNREMISTS LSPQKSSGFSGRRRSSSVRDALSSFFGTGNSPTSSMDDYSNLMNRNYSTASTAMCRGN SFPSDVGTKAYNITGSYQPDRHRNSVPYTTIDQLHTRQDTGLRRESDPVAAKQISSNN DIVRSFITHHASNSTMFINRVLSDYLADRGFIKQTPLYNKKSVLEISIATSAESVFLP TTKSDETEYLSLIHGSLNQARTQPVGSTNTAESDFLPSCPTMDTLNENNDLSLFPLHT QRTSPSNTARTGNAMDTSNSDRASPASNNNTTDADSFVASGNNNPMNNNNSPARNRHP NSHSRSLPNAWNSQMPSFSFALIFSLNKSTTLSDIKVELTSNVRVVWFNGLPPTKNVN EECYNIGSLDWTLNADNFNLFIPQGAKSPLDIVENHSNNRKLKVLQKLSMRKRRSFSN KAVLRENILNNLNASNSTNKLNAGVYVFTIPIVLASRIPESLYYPSARVSYSLRLATK LKDEHTQLVASRPRSSSISSPQKLRSYSCSDSYEYSQIDDTIEGETYNNDKNSTGKIA FPSSWLKSAKGRLKRNNSNGRSDNNGASSSGLAMQHDSEDTINLQYPLNLVRTPPEIS VTTANKPLYINKVWENCLSYEISFAQKYVPLNGEIPITIKVAPLVKSLSVKRIRVSCR EKISYRSKDYQYDFDQLDPLASDPCNPYHMRYLVRKKKDRSLPLFEVASKCTSGPSIR EEVVTNTVDDNLLAYTSSKENNKDIPFSESFTVKTKLKFPKYCEVDATKAASLPPYGI DLFDPIKDPTQSENTSNNGNVLGFLVGRPNRASKTVHKIPQDKNHNEVNDTNGNSNTS LQTSSNVPIQHYTRLNKPRRGLYLDSMHFKNIQCSHKLEIVLRVSKTDSGSSKIIRHY EVIVDTPIYLISDLCNTSNIDLPTYDMATTESSKVLPPTFEEATSVSASPRSSVSYYP DDISMQQLNLSRSTSLANGYLSTLHPKTTAVSDSSNGAPIRDQQEQQARPLRTEDYAL QMGNENNAYSNMDGLLSQDIFEQETAATLFKRDIVTMNFNNNIFTPRYSPRTFTNTDY NYNDNDNNDNDTEGPGPIIHPGPEPPRYDEISS" gene 631515..633761 /gene="NTO1" /locus_tag="YPR031W" mRNA 631515..633761 /gene="NTO1" /locus_tag="YPR031W" /product="Nto1p" CDS 631515..633761 /gene="NTO1" /locus_tag="YPR031W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0033100 NuA3 histone acetyltransferase complex [PMID:17157260]" /experiment="EXISTENCE:direct assay:GO:0035064 methylated histone binding [PMID:17142463]" /experiment="EXISTENCE:direct assay:GO:1990467 NuA3a histone acetyltransferase complex [PMID:25104842]" /experiment="EXISTENCE:direct assay:GO:1990468 NuA3b histone acetyltransferase complex [PMID:25104842]" /experiment="EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:17157260]" /note="Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3" /codon_start=1 /product="Nto1p" /protein_id="DAA11457.1" /db_xref="SGD:S000006235" /translation="MNRGSLDDGPKLREEKHFQDFYPDLNADTLLPFIVPLVETKDNS TDTDSDDISNRNNREIGSVKSVQTKELIFKGRVTTEPLVLKKNEVEFQKCKITTNELK GKKNPYCVRFNESFISRYYHINKVRNRKSYKQQQKEFDGVEAPYFTKFSSKEAPNITI STSTKSAIQKFASISPNLVNFKPQYDMDEQDELYLHYLNKRYFKDQMSHEIFEILMTT LETEWFHIEKHIPSTNSLIARHNILRDCKNYELYGSDDGTGLSMDQACAVCLGTDSDN LNTIVFCDGCDIAVHQECYGIIFIPEGKWLCRRCMISKNNFATCLMCPSHTGAFKQTD TGSWVHNICALWLPELYFSNLHYMEPIEGVQNVSVSRWKLNCYICKKKMGACIQCFQR NCFTAYHVTCARRAGLYMSKGKCTIQELASNQFSQKYSVESFCHKHAPRGWQTSIEGI NKARKYFSLLSTLQTETPQHNEANDRTNSKFNKTIWKTPNQTPVAPHVFAEILQKVVD FFGLANPPAGAFDICKYWSMKRELTGGTPLTACFENNSLGSLTEEQVQTRIDFANDQL EDLYRLKELTTLVKKRTQASNSLSRSRKKVFDIVKSPQKYLLKINVLDIFIKSEQFKA LERLVTEPKLLVILEKCKHCDFDTVQIFKEEIMHFFEVLETLPGASRILQTVSSKAKE QVTNLIGLIEHVDIKKLLSRDFIINDDKIEERPWSGPVIMEEEGLSDAEELSAGEHRM LKLILNSG" rep_origin 633874..634122 /note="ARS1623; Autonomously Replicating Sequence" /db_xref="SGD:S000118419" gene 634123..637224 /gene="SRO7" /locus_tag="YPR032W" /gene_synonym="SNI1" /gene_synonym="SOP1" mRNA 634123..637224 /gene="SRO7" /locus_tag="YPR032W" /gene_synonym="SNI1" /gene_synonym="SOP1" /product="Rab GTPase-binding protein SRO7" CDS 634123..637224 /gene="SRO7" /locus_tag="YPR032W" /gene_synonym="SNI1" /gene_synonym="SOP1" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10402465|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10402465]" /experiment="EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:16390997]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:22832273]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:10402465]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:10402465]" /experiment="EXISTENCE:physical interaction:GO:0000149 SNARE binding [PMID:15964280]" /experiment="EXISTENCE:physical interaction:GO:0007264 small GTPase-mediated signal transduction [PMID:16390997]" /experiment="EXISTENCE:physical interaction:GO:0030010 establishment of cell polarity [PMID:15964280]" /note="Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication" /codon_start=1 /product="Rab GTPase-binding protein SRO7" /protein_id="DAA11458.1" /db_xref="SGD:S000006236" /translation="MFGSKRLKNVKEAFKSLKGQNSETPIENSKASFKSKNSKTSTIS KDAKSSSSLKIPISSNNKNKIFSLAETNKYGMSSKPIAAAFDFTQNLLAIATVTGEVH IYGQQQVEVVIKLEDRSAIKEMRFVKGIYLVVINAKDTVYVLSLYSQKVLTTVFVPGK ITSIDTDASLDWMLIGLQNGSMIVYDIDRDQLSSFKLDNLQKSSFFPAARLSPIVSIQ WNPRDIGTVLISYEYVTLTYSLVENEIKQSFIYELPPFAPGGDFSEKTNEKRTPKVIQ SLYHPNSLHIITIHEDNSLVFWDANSGHMIMARTVFETEINVPQPDYIRDSSTNAAKI SKVYWMCENNPEYTSLLISHKSISRGDNQSLTMIDLGYTPRYSITSYEGMKNYYANPK QMKIFPLPTNVPIVNILPIPRQSPYFAGCHNPGLILLILGNGEIETMLYPSGIFTDKA SLFPQNLSWLRPLATTSMAASVPNKLWLGALSAAQNKDYLLKGGVRTKRQKLPAEYGT AFITGHSNGSVRIYDASHGDIQDNASFEVNLSRTLNKAKELAVDKISFAAETLELAVS IETGDVVLFKYEVNQFYSVENRPESGDLEMNFRRFSLNNTNGVLVDVRDRAPTGVRQG FMPSTAVHANKGKTSAINNSNIGFVGIAYAAGSLMLIDRRGPAIIYMENIREISGAQS ACVTCIEFVIMEYGDDGYSSILMVCGTDMGEVITYKILPASGGKFDVQLMDITNVTSK GPIHKIDAFSKETKSSCLATIPKMQNLSKGLCIPGIVLITGFDDIRLITLGKSKSTHK GFKYPLAATGLSYISTVEKNNDRKNLTVIITLEINGHLRVFTIPDFKEQMSEHIPFPI AAKYITESSVLRNGDIAIRVSEFQASLFSTVKEQDTLAPVSDTLYINGIRIPYRPQVN SLQWARGTVYCTPAQLNELLGGVNRPASKYKESIIAEGSFSERSSDDNNANHPEHQYT KPTRKGRNSSYGVLRNVSRAVETRWDAVEDRFNDYATAMGETMNEAVEQTGKDVMKGA LGF" gene complement(637379..639019) /gene="HTS1" /locus_tag="YPR033C" /gene_synonym="TS4572" /gene_synonym="TSM4572" mRNA complement(637379..639019) /gene="HTS1" /locus_tag="YPR033C" /gene_synonym="TS4572" /gene_synonym="TSM4572" /product="histidine--tRNA ligase" CDS complement(637379..639019) /gene="HTS1" /locus_tag="YPR033C" /gene_synonym="TS4572" /gene_synonym="TSM4572" /EC_number="6.1.1.21" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0004812 aminoacyl-tRNA ligase activity [PMID:16741232]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006427 histidyl-tRNA aminoacylation [PMID:16741232]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /experiment="EXISTENCE:genetic interaction:GO:0032543 mitochondrial translation [PMID:16777356]" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:3521891]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:3521891]" /experiment="EXISTENCE:mutant phenotype:GO:0006427 histidyl-tRNA aminoacylation [PMID:1459448]" /note="Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome" /codon_start=1 /product="histidine--tRNA ligase" /protein_id="DAA11459.1" /db_xref="SGD:S000006237" /translation="MLSRSLNKVVTSIKSSSIIRMSSATAAATSAPTANAANALKASK APKKGKLQVSLKTPKGTKDWADSDMVIREAIFSTLSGLFKKHGGVTIDTPVFELREIL AGKYGEDSKLIYNLEDQGGELCSLRYDLTVPFARYVAMNNIQSIKRYHIAKVYRRDQP AMTKGRMREFYQCDFDVAGTFESMVPDSECLSILVEGLTSLGIKDFKIKLNHRKILDG IFQIAGVKDEDVRKISSAVDKLDKSPWEAVKKEMTEEKGQSEETADKIGEYVKLNGSL KEIHAVLSADANITSNEKAKQGLDDIATLMKYTEAFDIDSFISFDLSLARGLDYYTGL IYEVVTSASAPPENASELKKKAKSAEDASEFVGVGSIAAGGRYDNLVNMFSEASGKKS TQIPCVGISFGVERIFSLIKQRINSSTTIKPTATQVFVMAFGGGKDWTGYLPERMKVT KQLWDAGIEAEYVYKAKANPRKQFDAAEKAGCHIAVILGKEEYLEGKLRVKRLGQEFA DDDGELVSAADIVPIVQEKLSQIHEDGLNEVTRLIKGL" gene 639525..640958 /gene="ARP7" /locus_tag="YPR034W" /gene_synonym="RSC11" /gene_synonym="SWP61" mRNA 639525..640958 /gene="ARP7" /locus_tag="YPR034W" /gene_synonym="RSC11" /gene_synonym="SWP61" /product="Arp7p" CDS 639525..640958 /gene="ARP7" /locus_tag="YPR034W" /gene_synonym="RSC11" /gene_synonym="SWP61" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11011149]" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12183366]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:17081996]" /experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:8127913|PMID:9726966|PMID:18644858]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:10619019|PMID:12183366]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9726966]" /note="Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation" /codon_start=1 /product="Arp7p" /protein_id="DAA11460.1" /db_xref="SGD:S000006238" /translation="MTLNRKCVVIHNGSHRTVAGFSNVELPQCIIPSSYIKRTDEGGE AEFIFGTYNMIDAAAEKRNGDEVYTLVDSQGLPYNWDALEMQWRYLYDTQLKVSPEEL PLVITMPATNGKPDMAILERYYELAFDKLNVPVFQIVIEPLAIALSMGKSSAFVIDIG ASGCNVTPIIDGIVVKNAVVRSKFGGDFLDFQVHERLAPLIKEENDMENMADEQKRST DVWYEASTWIQQFKSTMLQVSEKDLFELERYYKEQADIYAKQQEQLKQMDQQLQYTAL TGSPNNPLVQKKNFLFKPLNKTLTLDLKECYQFAEYLFKPQLISDKFSPEDGLGPLMA KSVKKAGASINSMKANTSTNPNGLGTSHINTNVGDNNSTASSSNISPEQVYSLLLTNV IITGSTSLIEGMEQRIIKELSIRFPQYKLTTFANQVMMDRKIQGWLGALTMANLPSWS LGKWYSKEDYETLKRDRKQSQATNATN" gene 642208..643320 /gene="GLN1" /locus_tag="YPR035W" mRNA 642208..643320 /gene="GLN1" /locus_tag="YPR035W" /product="glutamate--ammonia ligase" CDS 642208..643320 /gene="GLN1" /locus_tag="YPR035W" /EC_number="6.3.1.2" /experiment="EXISTENCE:direct assay:GO:0004356 glutamine synthetase activity [PMID:4156034]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006542 glutamine biosynthetic process [PMID:6129248]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:mutant phenotype:GO:0004356 glutamine synthetase activity [PMID:1347768]" /note="Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; forms filaments of back-to-back stacks of cylindrical homo-decamers at low pH, leading to enzymatic inactivation and storage during states of advanced cellular starvation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" /codon_start=1 /product="glutamate--ammonia ligase" /protein_id="DAA11461.2" /db_xref="SGD:S000006239" /translation="MAEASIEKTQILQKYLELDQRGRIIAEYVWIDGTGNLRSKGRTL KKRITSIDQLPEWNFDGSSTNQAPGHDSDIYLKPVAYYPDPFRRGDNIVVLAACYNND GTPNKFNHRHEAAKLFAAHKDEEIWFGLEQEYTLFDMYDDVYGWPKGGYPAPQGPYYC GVGAGKVYARDMIEAHYRACLYAGLEISGINAEVMPSQWEFQVGPCTGIDMGDQLWMA RYFLHRVAEEFGIKISFHPKPLKGDWNGAGCHTNVSTKEMRQPGGMKYIEQAIEKLSK RHAEHIKLYGSDNDMRLTGRHETASMTAFSSGVANRGSSIRIPRSVAKEGYGYFEDRR PASNIDPYLVTGIMCETVCGAIDNADMTKEFERESS" gene 643836..645272 /gene="VMA13" /locus_tag="YPR036W" /gene_synonym="CLS11" mRNA 643836..645272 /gene="VMA13" /locus_tag="YPR036W" /gene_synonym="CLS11" /product="H(+)-transporting V1 sector ATPase subunit H" CDS 643836..645272 /gene="VMA13" /locus_tag="YPR036W" /gene_synonym="CLS11" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:23708375]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:18708638]" /note="Subunit H of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits" /codon_start=1 /product="H(+)-transporting V1 sector ATPase subunit H" /protein_id="DAA11462.1" /db_xref="SGD:S000006240" /translation="MGATKILMDSTHFNEIRSIIRSRSVAWDALARSEELSEIDASTA KALESILVKKNIGDGLSSSNNAHSGFKVNGKTLIPLIHLLSTSDNEDCKKSVQNLIAE LLSSDKYGDDTVKFFQEDPKQLEQLFDVSLKGDFQTVLISGFNVVSLLVQNGLHNVKL VEKLLKNNNLINILQNIEQMDTCYVCIRLLQELAVIPEYRDVIWLHEKKFMPTLFKIL QRATDSQLATRIVATNSNHLGIQLQYHSLLLIWLLTFNPVFANELVQKYLSDFLDLLK LVKITIKEKVSRLCISIILQCCSTRVKQHKKVIKQLLLLGNALPTVQSLSERKYSDEE LRQDISNLKEILENEYQELTSFDEYVAELDSKLLCWSPPHVDNGFWSDNIDEFKKDNY KIFRQLIELLQAKVRNGDVNAKQEKIIIQVALNDITHVVELLPESIDVLDKTGGKADI MELLNHSDSRVKYEALKATQAIIGYTFK" gene 645950..646153 /gene="SPO24" /locus_tag="YPR036W-A" mRNA 645950..646153 /gene="SPO24" /locus_tag="YPR036W-A" /product="Spo24p" CDS 645950..646153 /gene="SPO24" /locus_tag="YPR036W-A" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:25127041]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:25127041]" /note="Small (67 amino acids) protein involved in sporulation; localizes to the prospore membrane; phosphorylated during meiosis; a longer, 5'-extended mRNA is also transcribed beginning in mid-meiosis, regulated by two MSEs (middle sporulation elements), and includes an uORF of 15 codons in its 5'-UTR; evidence transcription is regulated by Pdr1p" /codon_start=1 /product="Spo24p" /protein_id="DAA11463.1" /db_xref="SGD:S000028425" /translation="MVAFLELTSDVSQPFVIPSLSPVSQPSSRKNSDANVDDLNLAIA NAALLDASASSRSHSRKNSLSLL" gene complement(646448..647038) /gene="ERV2" /locus_tag="YPR037C" mRNA complement(646448..647038) /gene="ERV2" /locus_tag="YPR037C" /product="flavin-linked sulfhydryl oxidase" CDS complement(646448..647038) /gene="ERV2" /locus_tag="YPR037C" /EC_number="1.8.3.2" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11584268]" /experiment="EXISTENCE:direct assay:GO:0016971 flavin-dependent sulfhydryl oxidase activity [PMID:11584268]" /experiment="EXISTENCE:direct assay:GO:0016972 thiol oxidase activity [PMID:11313344]" /experiment="EXISTENCE:direct assay:GO:0060904 regulation of protein folding in endoplasmic reticulum [PMID:11584268]" /note="Flavin-linked sulfhydryl oxidase localized to the ER lumen; involved in disulfide bond formation within the endoplasmic reticulum (ER)" /codon_start=1 /product="flavin-linked sulfhydryl oxidase" /protein_id="DAA11464.1" /db_xref="SGD:S000006241" /translation="MKQIVKRSHAIRIVAALGIIGLWMFFSSNELSIATPGLIKAKSG IDEVQGAAAEKNDARLKEIEKQTIMPLMGDDKVKKEVGRASWKYFHTLLARFPDEPTP EEREKLHTFIGLYAELYPCGECSYHFVKLIEKYPVQTSSRTAAAMWGCHIHNKVNEYL KKDIYDCATILEDYDCGCSDSDGKRVSLEKEAKQHG" gene 646836..647195 /gene="IRC16" /locus_tag="YPR038W" mRNA 646836..647195 /gene="IRC16" /locus_tag="YPR038W" /product="Irc16p" CDS 646836..647195 /gene="IRC16" /locus_tag="YPR038W" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:18085829]" /note="hypothetical protein; partially overlaps verified gene ERV2/YPR037C but doesn't share phenotypes; also overlaps dubious ORF YPR039W; null mutant displays increased levels of spontaneous Rad52p foci, increased biofilm information, different altered sensitivities to various chemcicals" /codon_start=1 /product="Irc16p" /protein_id="DAD54812.1" /db_xref="SGD:S000006242" /translation="MVCFSISFNRASFFSAAAPCTSSIPDFALIRPGVAMDSSLDEKN IHRPMIPNAATILMAWLLLTICFIPSFLAQSVQTFLFTNHQPSRLLVFITHVYCLMIK PFVLYFWFLFPLRLPGG" gene 647305..648375 /gene="TIP41" /locus_tag="YPR040W" mRNA 647305..648375 /gene="TIP41" /locus_tag="YPR040W" /product="Tip41p" CDS 647305..648375 /gene="TIP41" /locus_tag="YPR040W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:11741537]" /note="Tap42p-interacting protein; negative regulator of the TORC1 signaling pathway that activates the type 2A-related phosphatase Sit4p by binding and antagonizing Tap42p, a SIT4 inhibitor; proposed to be part of a feedback loop to amplify Sit4p activity when TORC1 is inactivated; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="Tip41p" /protein_id="DAA11465.1" /db_xref="SGD:S000006244" /translation="MSKRNTPPLRSSGINTIQINAAREMHAQTVRARRMPMPTSGITT PSVQPTAAPATPPRHICNNPNNPQCLHCGSVIIPSPRATLPLEDNPSISINDWTISSR KKPILNSQELDIWENEKLKGLTLPEMIFGNNYIRIENSKQHWSIEFNALDALKEVQLQ DSGIRVAYSNDWINSKKRQNSTNGAQRFTNDVNDDSLNIIHKYDWTYTTRYKGTESSP ESKFRLDNDQKLPLDKLAVHDKILFYDDMILFEDELADNGISILNVKIRVMNERLLLL SRFFLRVDDVLVRVYDTRIYVEFDENVVIRESKEFEGKYQDVLAKHRLSQSHDPKAAL RDSNWVAQNTPMIKRQCEIIQF" gene 648704..649921 /gene="TIF5" /locus_tag="YPR041W" /gene_synonym="SUI5" mRNA 648704..649921 /gene="TIF5" /locus_tag="YPR041W" /gene_synonym="SUI5" /product="translation initiation factor eIF5" CDS 648704..649921 /gene="TIF5" /locus_tag="YPR041W" /gene_synonym="SUI5" /experiment="EXISTENCE:direct assay:GO:0001732 formation of cytoplasmic translation initiation complex [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0005092 GDP-dissociation inhibitor activity [PMID:20485439]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:9308967]" /experiment="EXISTENCE:direct assay:GO:0006446 regulation of translational initiation [PMID:22851688]" /experiment="EXISTENCE:direct assay:GO:0031369 translation initiation factor binding [PMID:15145951|PMID:16380131|PMID:22683627]" /experiment="EXISTENCE:direct assay:GO:0033290 eukaryotic 48S preinitiation complex [PMID:17242201]" /experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF complex [PMID:11018020|PMID:15838098]" /experiment="EXISTENCE:genetic interaction:GO:0045947 negative regulation of translational initiation [PMID:20485439]" /experiment="EXISTENCE:mutant phenotype:GO:0005092 GDP-dissociation inhibitor activity [PMID:20485439]" /experiment="EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:9308967]" /experiment="EXISTENCE:mutant phenotype:GO:0006446 regulation of translational initiation [PMID:22851688|PMID:11331597]" /experiment="EXISTENCE:mutant phenotype:GO:0042256 cytosolic ribosome assembly [PMID:11331597]" /experiment="EXISTENCE:mutant phenotype:GO:0045947 negative regulation of translational initiation [PMID:20485439]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:9395514|PMID:22683627]" /experiment="EXISTENCE:physical interaction:GO:0031369 translation initiation factor binding [PMID:22851688|PMID:15145951]" /note="Translation initiation factor eIF5; functions as both a GTPase-activating protein (GAP) that stimulates the hydrolysis of GTP bound to eIF-2, as part of the 43S preinitiation complex, and as a GDP dissociation inhibitor (GDI) to prevent recycling of eIF2; human ortholog eIF5 complements the yeast null mutant" /codon_start=1 /product="translation initiation factor eIF5" /protein_id="DAA11466.1" /db_xref="SGD:S000006245" /translation="MSINICRDNHDPFYRYKMPPIQAKVEGRGNGIKTAVLNVADISH ALNRPAPYIVKYFGFELGAQTSISVDKDRYLVNGVHEPAKLQDVLDGFINKFVLCGSC KNPETEIIITKDNDLVRDCKACGKRTPMDLRHKLSSFILKNPPDSVSGSKKKKKAATA SANVRGGGLSISDIAQGKSQNAPSDGTGSSTPQHHDEDEDELSRQIKAAASTLEDIEV KDDEWAVDMSEEAIRARAKELEVNSELTQLDEYGEWILEQAGEDKENLPSDVELYKKA AELDVLNDPKIGCVLAQCLFDEDIVNEIAEHNAFFTKILVTPEYEKNFMGGIERFLGL EHKDLIPLLPKILVQLYNNDIISEEEIMRFGTKSSKKFVPKEVSKKVRRAAKPFITWL ETAESDDDEEDDE" gene complement(650435..653662) /gene="PUF2" /locus_tag="YPR042C" mRNA complement(650435..653662) /gene="PUF2" /locus_tag="YPR042C" /product="Puf2p" CDS complement(650435..653662) /gene="PUF2" /locus_tag="YPR042C" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640|PMID:21685478|PMID:15024427]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:11101532]" /note="PUF family mRNA-binding protein; Pumilio homology domain confers RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins; binding site composed of two UAAU tetranucleotides, separated by a 3-nt linker; PUF2 has a paralog, JSN1, that arose from the whole genome duplication" /codon_start=1 /product="Puf2p" /protein_id="DAA11467.1" /db_xref="SGD:S000006246" /translation="MDNKRLYNGNLSNIPEVIDPGITIPIYEEDIRNDTRMNTNARSV RVSDKRGRSSSTSPQKIGSYRTRAGRFSDTLTNLLPSISAKLHHSKKSTPVVVVPPTS STPDSLNSTTYAPRVSSDSFTVATPLSLQSTTTRTRTRNNTVSSQITASSSLTTDVGN ATSANIWSANAESNTSSSPLFDYPLATSYFEPLTRFKSTDNYTLPQTAQLNSFLEKNG NPNIWSSAGNSNTDHLNTPIVNRQRSQSQSTTNRVYTDAPYYQQPAQNYQVQVPPRVP KSTSISPVILDDVDPASINWITANQKVPLVNQISALLPTNTISISNVFPLQPTQQHQQ NAVNLTSTSLATLCSQYGKVLSARTLRGLNMALVEFSTVESAICALEALQGKELSKVG APSTVSFARVLPMYEQPLNVNGFNNTPKQPLLQEQLNHGVLNYQLQQSLQQPELQQQP TSFNQPNLTYCNPTQNLSHLQLSSNENEPYPFPLPPPSLSDSKKDILHTISSFKLEYD HLELNHLLQNALKNKGVSDTNYFGPLPEHNSKVPKRKDTFDAPKLRELRKQFDSNSLS TIEMEQLAIVMLDQLPELSSDYLGNTVIQKLFENSSNIIRDIMLRKCNKYLTSMGVHK NGTWVCQKIIKMANTPRQINLVTSGVSDYCTPLFNDQFGNYVIQGILKFGFPWNSFIF ESVLSHFWTIVQNRYGSRAVRACLEADSIITQCQLLTITSLIIVLSPYLATDTNGTLL ITWLLDTCTLPNKNLILCDKLVNKNLVKLCCHKLGSLTVLKILNLRGGEEEALSKNKI IHAIFDGPISSDSILFQILDEGNYGPTFIYKVLTSRILDNSVRDEAITKIRQLILNSN INLQSRQLLEEVGLSSAGISPKQSSKNHRKQHPQGFHSPGRARGVSVSSVRSSNSRHN SVIQMNNAGPTPALNFNPAPMSEINSYFNNQQVVYSGNQNQNQNGNSNGLDELNSQFD SFRIANGTNLSLPIVNLPNVSNNNNNYNNSGYSSQMNPLSRSVSHNNNNNTNNYNNND NDNNNNNNNNNNNNNNNNNNNNNSNNSNNNNNNDTSLYRYRSYGY" gene 654166..654847 /gene="RPL43A" /locus_tag="YPR043W" mRNA join(654166..654167,654571..654847) /gene="RPL43A" /locus_tag="YPR043W" /product="ribosomal 60S subunit protein L43A" CDS join(654166..654167,654571..654847) /gene="RPL43A" /locus_tag="YPR043W" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication" /codon_start=1 /product="ribosomal 60S subunit protein L43A" /protein_id="DAA11468.1" /db_xref="SGD:S000006247" /translation="MAKRTKKVGITGKYGVRYGSSLRRQVKKLEIQQHARYDCSFCGK KTVKRGAAGIWTCSCCKKTVAGGAYTVSTAAAATVRSTIRRLREMVEA" gene complement(655140..656552) /gene="THP3" /locus_tag="YPR045C" mRNA complement(655140..656552) /gene="THP3" /locus_tag="YPR045C" /product="Thp3p" CDS complement(655140..656552) /gene="THP3" /locus_tag="YPR045C" /experiment="EXISTENCE:direct assay:GO:0000791 euchromatin [PMID:21149575]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:19061648]" /note="Protein that may have a role in transcription elongation; forms a complex with Csn12p that is recruited to transcribed genes; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes" /codon_start=1 /product="Thp3p" /protein_id="DAA11469.1" /db_xref="SGD:S000006249" /translation="MQNPYGHFTNNTTEDREASSQGGPFGQSLNRPLDYAGSFPSLTY NNNNFIANQQPSLPLPEPRLSWNNVNQVSNPLMVTPLPGLQKRMNKNIKKKLPRVSKK ASALSNGVSGNVMSNSNIVGHGAVGSASGWKVEMGGSDELERRKRRAERFSQGPSATT NSNDNLNEDFANLNAISSKSHQYDKKIHVVGRCQTLEKSYLRLTSEPNPDLIRPPNIL QKMYCLLMDKYQSKTATYTYLCDQFKSMRQDLRVQMIENSFTIKVYQTHARIALENGD LGEFNQCQNRIMALFENPTIPKKSYSEFICYSVLYSMLTEDYPSISHLKLKLIDDGSS EILEDEHVKMIFELSDMKLVGNYHYFMKNYLKLHKFEKCLINSFLNLEKLIFLTIICK SYNQVNLDFVKSEFNFNSIEETTNFLNEQNLTEFILNKQITDSNGKSSNIKILNTKGC RVQLIQNYMKSKKIDIKGQK" gene 656799..657344 /gene="MCM16" /locus_tag="YPR046W" mRNA 656799..657344 /gene="MCM16" /locus_tag="YPR046W" /product="Mcm16p" CDS 656799..657344 /gene="MCM16" /locus_tag="YPR046W" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11782448]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:11782448]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:19730685]" /note="Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3" /codon_start=1 /product="Mcm16p" /protein_id="DAA11470.1" /db_xref="SGD:S000006250" /translation="MTNSSEKQWERIQQLEKEHVEVYRELLITLDRLYLIRKHNHAVI LSHTQQRLLEIRHQLQINLEKTALLIRLLEKPDNTNVLFTKLQNLLEESNSLDYELLQ SLGAQSSLHKQLIESRAERDELMSKLIELSSKFPKPTIPPDDSDTAGKQVEVEKENET IQELMIALQIHSGYTNISYTI" gene 657529..658938 /gene="MSF1" /locus_tag="YPR047W" mRNA 657529..658938 /gene="MSF1" /locus_tag="YPR047W" /product="phenylalanine--tRNA ligase" CDS 657529..658938 /gene="MSF1" /locus_tag="YPR047W" /EC_number="6.1.1.20" /experiment="EXISTENCE:direct assay:GO:0004826 phenylalanine-tRNA ligase activity [PMID:16162501]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0004826 phenylalanine-tRNA ligase activity [PMID:3029120]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:3029120]" /experiment="EXISTENCE:mutant phenotype:GO:0070156 mitochondrial phenylalanyl-tRNA aminoacylation [PMID:3029120]" /note="Mitochondrial phenylalanyl-tRNA synthetase; active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase" /codon_start=1 /product="phenylalanine--tRNA ligase" /protein_id="DAA11471.1" /db_xref="SGD:S000006251" /translation="MFLNRMMKTRTGLYRLYSTLKVPHVEINGIKYKTDPQTTNVTDS IIKLTDRSLHLKESHPVGILRDLIEKKLNSVDNTFKIFNNFKPVVTTMENFDSLGFPK DHPGRSKSDTYYINETHLLRTHTSAHELECFQKIRNDSDNIKSGFLISADVYRRDEID KTHYPVFHQMEGATIWKRTKADVGVKEPMYIEKIREDIRQVENLLNKENVKITVDDDT IPLKENNPKQEYMSDLEVDLCSQHLKRSIELIVSEVFNKKISSMIKNKANNTPKELKV RWINAYFPWTAPSWEIEVWWQGEWLELCGCGLIRQDVLLRAGYKPSETIGWAFGLGLD RIAMLLFEIPDIRLLWSRDERFSRQFSKGLITSFKPYSKHPGSFRDVAFWLPEDKPDI HQVHENDLMEIIRNIAGDLVESVKLVDSFTHPKTGRKSMCYRINYQSMDRNLTNAEVN TLQDMVCSKLVKEYSVELR" gene 659182..661053 /gene="TAH18" /locus_tag="YPR048W" mRNA 659182..661053 /gene="TAH18" /locus_tag="YPR048W" /product="NAPDH-dependent diflavin reductase" CDS 659182..661053 /gene="TAH18" /locus_tag="YPR048W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19194512]" /experiment="EXISTENCE:direct assay:GO:0016651 oxidoreductase activity, acting on NAD(P)H [PMID:20802492]" /experiment="EXISTENCE:mutant phenotype:GO:0006809 nitric oxide biosynthetic process [PMID:23159617]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:20802492]" /experiment="EXISTENCE:mutant phenotype:GO:0045429 positive regulation of nitric oxide biosynthetic process [PMID:27178802]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27178802]" /note="Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance; possible target for development of antifungal drugs" /codon_start=1 /product="NAPDH-dependent diflavin reductase" /protein_id="DAA11472.1" /db_xref="SGD:S000006252" /translation="MSSSKKIVILYGSETGNAHDFATILSHRLHRWHFSHTFCSIGDY DPQDILKCRYLFIICSTTGQGELPRNVNALKGERPVTFWSFLKRKNLPSNLLNHIQTA MLGLGDSSYPKFNYGIRKLHQRIVTQLGANELFDRLEADDQAMAGSNKGTGLGIESVY FEYEKKVLSFLLSKYPNRKVNGQIIKREELDPEVYLEPASYLQLSDEHANEKFTSTKV IFEGDESLKVGRVNINKRITSEGHFQDVRQFKFSNVDKIQENYEPGDTVTIYPCNTDE DVSRFLANQSHWLEIADKPLNFTSGVPNDLKDGGLVRPMTLRNLLKYHCDFMSIPRTS FFLKIWTFATDVTKMERGQEQLNDQREKLRQFATDQDMQDLYDYCNRPRRSILEVLED FISVKLPWKYVLDYLPIIKPRYYSISSGPGDPNIELTVAIVKYKTILRKIRRGICTNY IARLQEGEQIRYKLQNNHIIKKEFLNKPMILVGPGVGLAPLLSVVKAEISKDIKLLFG CRYKDKDYIYKDMLEDWFRKGKIALHSSFSRDEENSPGVKYVQDYLWRLGEEITNLVV NKDAVFFLCGSSGKMPIQVRLTFIEMLKKWGNFSDEETAKKYLKEMEKSDRYIQETW" gene complement(661137..664673) /gene="ATG11" /locus_tag="YPR049C" /gene_synonym="CVT3" /gene_synonym="CVT9" mRNA complement(661137..664673) /gene="ATG11" /locus_tag="YPR049C" /gene_synonym="CVT3" /gene_synonym="CVT9" /product="autophagy protein ATG11" CDS complement(661137..664673) /gene="ATG11" /locus_tag="YPR049C" /gene_synonym="CVT3" /gene_synonym="CVT9" /experiment="EXISTENCE:direct assay:GO:0000045 autophagosome assembly [PMID:18725539]" /experiment="EXISTENCE:direct assay:GO:0000149 SNARE binding [PMID:26774783]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:15659643]" /experiment="EXISTENCE:direct assay:GO:0006914 autophagy [PMID:28013049]" /experiment="EXISTENCE:direct assay:GO:0006995 cellular response to nitrogen starvation [PMID:18725539|PMID:26774783]" /experiment="EXISTENCE:direct assay:GO:0034497 protein localization to phagophore assembly site [PMID:23858448|PMID:26774783]" /experiment="EXISTENCE:genetic interaction:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:15659643]" /experiment="EXISTENCE:genetic interaction:GO:0060090 molecular adaptor activity [PMID:17295840]" /experiment="EXISTENCE:genetic interaction:GO:2000786 positive regulation of autophagosome assembly [PMID:18077553]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:11309418]" /experiment="EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:12479808]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:15659643]" /experiment="EXISTENCE:mutant phenotype:GO:0034517 ribophagy [PMID:27659307]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:26181331]" /note="Adapter protein for pexophagy and the Cvt targeting pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the PAS; recruits Dnm1p to facilitate fission of mitochondria that are destined for removal by mitophagy" /codon_start=1 /product="autophagy protein ATG11" /protein_id="DAA11473.1" /db_xref="SGD:S000006253" /translation="MADADEYSTAPTQQEITPLQTTATIINAISGECITTNVDFFVSL DKFKQFIARKWKIPPDQLLILLPYGNKLKPSMFKELLINRSFTLNDFYVYDRRLFSLV SKPTPTNLLTSKDSNPMNSPNSNDLTETLEYLIKNSHISQYQGSDTIMIKPMPSPLED ADVDLSRLNYHSVTSLLTTNLGWLSALEIDVHYFKSLIPDIIAHIKRIFDGLTVCSQY LKLYCFDVESLYNSNVQFLNQLVDNGMTSKWEKCFNDTLSKLTALEGDSLQKFINIES LLENEKSVKILNHSINGKLNKIKREIDENASFRDIITVNIDRLRQMFTPNESKFELED QMAESFEVLVSEMRTRSRNVLDKEEEEFNSQEFLKSMNVMLEKDKKESVKTLFTISQA LYSQIGELIDLKKSLQKHAVAILGNIAFTQMEILGIKRLLLNECNKDLELYKKYEVEF AQVEDLPLIYGLYLIEKYRRLSWFQQILSFISNFNQDLELFKQNELRTRNKWVKNFGS IATVFCEDLLSSSDFKRLNEYHSHTSPPNEDEEDENENSIANYRQDLVKVSQAIDNYM TQIKETDVSEPIIDLLSKTLFETKRFHIIYSNFKNNNNNSSNGNSISPEGSIALKSDD VVKGYKTRIKKLESLLHEFQYSDIGHWPQGVLNTHLKPFRGSATSINKKKFLGASVLL EPANISEVNIDSVSQANNHQIQELESNVDDLLHQLQLLKEENNRKSMQISEMGKKISD LEVEKTAYRETLTNLNQELARLTNEEQSHRTEIFTLNASFKKQLNDIISQDNEKIEKL TGDYDDVSKSRERLQMDLDESNKKHEQEVNLLKADIERLGKQIVTSEKSYAETNSSSM EKGEKFETIPLAEDPGRENQISAYTQTLQDRIFDIISTNIFILENIGLLLTFDNNNNI QIRRVKGLKKGTAQSNILDESTQMLDAHDNSLIKSPVFQKLKDEYELIKSVANGSEKD TQQSIFLGNITQLYDNKLYEVAVIRRFKDIETLAKKLTKENKIKRTLLERFQREKVTL RNFQIGDLALFLPTRENVNSVGSMSSSTSSLSSSFSSVDLSTPPPLDAMSIQSSPSVI HSNVINQASISGRDKNKLMRPWAAFTAFEESTRYFLKDEKGLTKGKEWFVGRIVTLEH FVADSPSNNPFRLPKGSVWFQVTAVVVSYQGV" gene 664960..665490 /gene="MAK3" /locus_tag="YPR051W" /gene_synonym="NAA30" mRNA 664960..665490 /gene="MAK3" /locus_tag="YPR051W" /gene_synonym="NAA30" /product="peptide alpha-N-acetyltransferase MAK3" CDS 664960..665490 /gene="MAK3" /locus_tag="YPR051W" /gene_synonym="NAA30" /EC_number="2.3.1.256" /experiment="EXISTENCE:direct assay:GO:0031417 NatC complex [PMID:10504710]" /experiment="EXISTENCE:mutant phenotype:GO:0004596 peptide alpha-N-acetyltransferase activity [PMID:11274203]" /experiment="EXISTENCE:mutant phenotype:GO:0006474 N-terminal protein amino acid acetylation [PMID:11274203]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:15911569|PMID:17261844|PMID:15077113|PMID:15077114]" /note="Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT); involved in subcellular targeting of select N-terminally acetylated substrates to the Golgi apparatus (Arl3p and Grh1p) and the inner nuclear membrane (Trm1p); required for replication of dsRNA virus; human NatC ortholog, NAA30, functionally complements the null, requiring either auxiliary subunit Mak10p or co-expression of human ortholog, NAA35; NAA60, the human NatF gene, also complements the null allele" /codon_start=1 /product="peptide alpha-N-acetyltransferase MAK3" /protein_id="DAA11474.1" /db_xref="SGD:S000006255" /translation="MEIVYKPLDIRNEEQFASIKKLIDADLSEPYSIYVYRYFLNQWP ELTYIAVDNKSGTPNIPIGCIVCKMDPHRNVRLRGYIGMLAVESTYRGHGIAKKLVEI AIDKMQREHCDEIMLETEVENSAALNLYEGMGFIRMKRMFRYYLNEGDAFKLILPLTE KSCTRSTFLMHGRLAT" gene complement(665693..665974) /gene="NHP6A" /locus_tag="YPR052C" mRNA complement(665693..665974) /gene="NHP6A" /locus_tag="YPR052C" /product="high-mobility group nucleosome-binding protein" CDS complement(665693..665974) /gene="NHP6A" /locus_tag="YPR052C" /experiment="EXISTENCE:direct assay:GO:0001195 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase III [PMID:16407207]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:3169249|PMID:17878171]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:19683499]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:7721780|PMID:9468494]" /experiment="EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:11432837|PMID:12952948|PMID:12805231]" /experiment="EXISTENCE:direct assay:GO:0032407 MutSalpha complex binding [PMID:19843605]" /experiment="EXISTENCE:direct assay:GO:0043392 negative regulation of DNA binding [PMID:19843605]" /experiment="EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:8946917]" /experiment="EXISTENCE:direct assay:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:16407207|PMID:17178828|PMID:11239460]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:14739928]" /experiment="EXISTENCE:genetic interaction:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:11533232]" /note="High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="high-mobility group nucleosome-binding protein" /protein_id="DAA11475.1" /db_xref="SGD:S000006256" /translation="MVTPREPKKRTTRKKKDPNAPKRALSAYMFFANENRDIVRSENP DITFGQVGKKLGEKWKALTPEEKQPYEAKAQADKKRYESEKELYNATLA" gene complement(665788..666243) /locus_tag="YPR053C" mRNA complement(665788..666243) /locus_tag="YPR053C" /product="hypothetical protein" CDS complement(665788..666243) /locus_tag="YPR053C" /note="hypothetical protein; conserved among S. cerevisiae strains; YPR053C is not an essential gene; partially overlaps verified ORF NHP6A/YPR052C" /codon_start=1 /product="hypothetical protein" /protein_id="DAA80345.1" /db_xref="SGD:S000006257" /translation="MMYRTTLNTVQVSQISGAEFYPHASSRAILFESPAFCRLFFSPF VYLAVGKQTTQYLLLVPTVKEGLFWDVFFSCFCSIDYPIHSKAQSQWSPQENLRREPL ERRRTQMPLRGLCPPTCFSLTKTEILFVLKIQISHLDKSARSWVRSGRL" gene 666280..667446 /gene="SMK1" /locus_tag="YPR054W" mRNA 666280..667446 /gene="SMK1" /locus_tag="YPR054W" /product="mitogen-activated protein kinase SMK1" CDS 666280..667446 /gene="SMK1" /locus_tag="YPR054W" /EC_number="2.7.11.24" /experiment="EXISTENCE:direct assay:GO:0004707 MAP kinase activity [PMID:16116083]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0070056 prospore membrane leading edge [PMID:33466572]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:16116083]" /experiment="EXISTENCE:mutant phenotype:GO:0004707 MAP kinase activity [PMID:16116083]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:16116083|PMID:7958885]" /experiment="EXISTENCE:mutant phenotype:GO:1904853 protein localization to ascospore wall [PMID:38874213]" /note="Middle sporulation-specific mitogen-activated protein kinase (MAPK); required for prospore membrane development and the production of outer spore wall layers; promotes deposition of the glucan layer of the spore wall by regulating the localization of Gsc2p to sites of spore wall assembly in postmeiotic cells; activated by Cak1p-mediated phosphorylation of threonine (T207) in the activation loop during meiosis I followed by Ssp2p-promoted autophosphorylation of tyrosine (T209) during meiosis II" /codon_start=1 /product="mitogen-activated protein kinase SMK1" /protein_id="DAA11476.1" /db_xref="SGD:S000006258" /translation="MNCTLTDNTRAINVASNLGAPQQRTIFAKERISIPGYYEIIQFL GKGAYGTVCSVKFKGRSPAARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHKNIVN LIDLEIVTSSPYDGLYCYQELIDYDLAKVIHSSVQLSEFHIKYFLYQILCGLKYIHSA DVIHRDLKPGNILCTLNGCLKICDFGLARGIHAGFFKCHSTVQPHITNYVATRWYRAP ELLLSNQPYSKSVDIWAVGCILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDKDILIK FGTIKAWNLGKNSNNPVYKKIPWSNIFPFASHEAINLIESLLHWDSTHRLNVEQAISH PFLNEVRKPDDEPVCLQGPFDFTYESELNSMSKLRDYLVEEVKNFKTDLSSSSL" gene 667676..670873 /gene="SEC8" /locus_tag="YPR055W" mRNA 667676..670873 /gene="SEC8" /locus_tag="YPR055W" /product="exocyst subunit SEC8" CDS 667676..670873 /gene="SEC8" /locus_tag="YPR055W" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:9491896]" /experiment="EXISTENCE:direct assay:GO:0000145 exocyst [PMID:1512289|PMID:7615633|PMID:8978675]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:7615633|PMID:9491896|PMID:12960429|PMID:22842922|PMI D:17717527]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922|PMID:12960429|PMID:9491896]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:6996832]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]" /experiment="EXISTENCE:mutant phenotype:GO:0048309 endoplasmic reticulum inheritance [PMID:15596717]" /experiment="EXISTENCE:mutant phenotype:GO:0048313 Golgi inheritance [PMID:15596717]" /note="Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress" /codon_start=1 /product="exocyst subunit SEC8" /protein_id="DAA11477.1" /db_xref="SGD:S000006259" /translation="MDYLKPAQKGRRRGLSINSLSETQQSAMNSSLDHLQNDLNRINL QWNRILSDNTNPLELALAFLDDTSVGLGHRYEEFNQLKSQIGSHLQDVVNEHSQVFNT NVASYGKAVSSIMQAQEQTLNLKNCLKEANEKITTDKGSLQELNDNNLKYTKMIDVLV NIEELLQIPEKIEENIRKENFHQVQILLERGFILMNNKSLKTVEILKPINQQLELQEH LLFNNLIEEIHDIMYSKSNKTNFTRVTNNDIFKIISISHNGFTSLENYLYNIVNIDIM EHSKTINKNLEQFIHDQSLNKGNIMLQENAATQAPLAPSRNQENEGFNRIGFLLKTIN NINKLPVAFNIITERAKEEIHNIIVKSTESIRSKHPSLLKMATSLKNDNHFGLPVQDI LSIILRECFWEIFLKLLYAIQCHRAIFEMSNILQPTSSAKPAFKFNKIWGKLLDEIEL LLVRYINDPELISSNNGSIKPINGATNNAPTLPKRKNPKIFSLEYNIEDNSSVKDQAF ELKALLKDIFPGFSVSSNMDLDSIYVKDESFEQDEPLVPPSVFNMKVILDPFLLFTQS TSTIVPSVLTQNTISSLTFFDDYMNKSFLPKIQMTMDYLFTVEVESNNPYALELSDEN HNIFKTALDFQRLFYNLLNVFNTANTFREKISYCILDLLNHFYNYYLGLFNSLIGTSD RHLTRKIITAWLQNGILMDQEQKILNGDETLFHEESIELFKEIPHFYQAGKGLSKSDL FNNLTLDTILQFSASVLWILNWLPGLKKAINIDEVSQEPMLDADRLRSSWTFSESMDL NYSNPSSSPNSLGNLKILLDDKASKKFDETIDGFKTLKFKLITILRFNIRALCIYDIG SFFQNTKIWNMDVGSIELDQNIASLISELRRTESKLKQQLPEKEKNSIFIGLDIVNNY ALIKGAKSIKVLNHNGIKKMLRNVNVLQHAYRNLSSEPSKINMNVTMNFYSLCGSSEA ELFEYIKDNELPHCSVEDLKTILRLQFSEEMHRQLKRQSTSSTKGSIKPSNKRYTEAL EKLSNLEKEQSKEGARTKIGKLKSKLNAVHTANEK" gene 671126..672142 /gene="TFB4" /locus_tag="YPR056W" mRNA 671126..672142 /gene="TFB4" /locus_tag="YPR056W" /product="TFIIH/NER complex subunit TFB4" CDS 671126..672142 /gene="TFB4" /locus_tag="YPR056W" /experiment="EXISTENCE:curator inference:GO:0016251 RNA polymerase II general transcription initiation factor activity [PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0000439 transcription factor TFIIH core complex [PMID:14500720|PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:19818408|PMID:27381459]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19818408]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:10506223]" /experiment="EXISTENCE:physical interaction:GO:0000112 nucleotide-excision repair factor 3 complex [PMID:10681587]" /note="Subunit of TFIIH complex; involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p" /codon_start=1 /product="TFIIH/NER complex subunit TFB4" /protein_id="DAA11478.1" /db_xref="SGD:S000006260" /translation="MDAISDPTFKHARSRKQVTEESPSLLTVIIEIAPKLWTTFDEEG NEKGSIIKVLEALIVFLNAHLAFNSANKVAVIAAYSQGIKYLYPESTSALKASESENK TRSDLKIINSDMYRRFRNVDETLVEEIYKLFELEKKQIEQNSQRSTLAGAMSAGLTYV NRISKESVTTSLKSRLLVLTCGSGSSKDEIFQYIPIMNCIFSATKMKCPIDVVKIGGS KESTFLQQTTDATNGVYLHVESTEGLIQYLATAMFIDPSLRPIIVKPNHGSVDFRTSC YLTGRVVAVGFICSVCLCVLSIIPPGNKCPACDSQFDEHVIAKLKRKPVVPRLKAKKK VTKP" gene 672471..673496 /gene="BRR1" /locus_tag="YPR057W" mRNA 672471..673496 /gene="BRR1" /locus_tag="YPR057W" /product="Brr1p" CDS 672471..673496 /gene="BRR1" /locus_tag="YPR057W" /experiment="EXISTENCE:direct assay:GO:0017069 snRNA binding [PMID:8861964]" /experiment="EXISTENCE:direct assay:GO:0030532 small nuclear ribonucleoprotein complex [PMID:8861964]" /experiment="EXISTENCE:mutant phenotype:GO:0000245 spliceosomal complex assembly [PMID:8861964]" /note="snRNP protein component of spliceosomal snRNPs; required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed" /codon_start=1 /product="Brr1p" /protein_id="DAA11479.1" /db_xref="SGD:S000006261" /translation="MKRGESQAPDAIFGQSRAFALSDSSVNPDVIEYLKSVRQEALRT NAISIKNHMNLQKRTRHKSSMYDDEDEGALKRHAISPSLIRLQRNVEIWVRWFNSVKA TVLTNAYEFTGYEDETLDLLLLFLKNYLEDMPSKCTTVEKIISVLNQHSFPEKAEEKE ENLQIDEEWAKNILVRLEKTKIDSVEDVKKVITEGDKHELVGYNQWFQYLINNEPQHT TFHEKITSKQLWVLIKYMSNTWIKEIHKKGRHYRRLQDWLFYILVHTPERVTAEYTSI LRDLGKKCLELIQKKPVEAHENKITLPKEMAELNVEIPAAVENMTITELTVSVIAVNY GQKDLIE" gene 673751..674674 /gene="YMC1" /locus_tag="YPR058W" mRNA 673751..674674 /gene="YMC1" /locus_tag="YPR058W" /product="organic acid transporter" CDS 673751..674674 /gene="YMC1" /locus_tag="YPR058W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:16140254]" /experiment="EXISTENCE:genetic interaction:GO:0005342 organic acid transmembrane transporter activity [PMID:16140254]" /experiment="EXISTENCE:genetic interaction:GO:0006783 heme biosynthetic process [PMID:26821380]" /experiment="EXISTENCE:genetic interaction:GO:0006839 mitochondrial transport [PMID:16140254]" /experiment="EXISTENCE:genetic interaction:GO:0015187 glycine transmembrane transporter activity [PMID:26821380]" /experiment="EXISTENCE:genetic interaction:GO:1904983 glycine import into mitochondrion [PMID:26821380]" /note="Secondary mitochondrial inner membrane glycine transporter; required with HEM25 for the transport of glycine into mitochondria for the initiation of heme biosynthesis; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; localizes to the vacuole in response to H2O2; YMC1 has a paralog, YMC2, that arose from the whole genome duplication" /codon_start=1 /product="organic acid transporter" /protein_id="DAA11480.1" /db_xref="SGD:S000006262" /translation="MSEEFPSPQLIDDLEEHPQHDNARVVKDLLAGTAGGIAQVLVGQ PFDTTKVRLQTSSTPTTAMEVVRKLLANEGPRGFYKGTLTPLIGVGACVSLQFGVNEA MKRFFHHRNADMSSTLSLPQYYACGVTGGIVNSFLASPIEHVRIRLQTQTGSGTNAEF KGPLECIKKLRHNKALLRGLTPTILREGHGCGTYFLVYEALIANQMNKRRGLERKDIP AWKLCIFGALSGTALWLMVYPLDVIKSVMQTDNLQKPKFGNSISSVAKTLYANGGIGA FFKGFGPTMLRAAPANGATFATFELAMRLLG" gene complement(674861..675631) /gene="ARO7" /locus_tag="YPR060C" /gene_synonym="HGS1" /gene_synonym="OSM2" /gene_synonym="TYR7" mRNA complement(674861..675631) /gene="ARO7" /locus_tag="YPR060C" /gene_synonym="HGS1" /gene_synonym="OSM2" /gene_synonym="TYR7" /product="chorismate mutase ARO7" CDS complement(674861..675631) /gene="ARO7" /locus_tag="YPR060C" /gene_synonym="HGS1" /gene_synonym="OSM2" /gene_synonym="TYR7" /EC_number="5.4.99.5" /experiment="EXISTENCE:direct assay:GO:0004106 chorismate mutase activity [PMID:3027508]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006571 tyrosine biosynthetic process [PMID:3027508]" /experiment="EXISTENCE:mutant phenotype:GO:0009094 L-phenylalanine biosynthetic process [PMID:3027508]" /note="Chorismate mutase; catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis" /codon_start=1 /product="chorismate mutase ARO7" /protein_id="DAA11481.1" /db_xref="SGD:S000006264" /translation="MDFTKPETVLNLQNIRDELVRMEDSIIFKFIERSHFATCPSVYE ANHPGLEIPNFKGSFLDWALSNLEIAHSRIRRFESPDETPFFPDKIQKSFLPSINYPQ ILAPYAPEVNYNDKIKKVYIEKIIPLISKRDGDDKNNFGSVATRDIECLQSLSRRIHF GKFVAEAKFQSDIPLYTKLIKSKDVEGIMKNITNSAVEEKILERLTKKAEVYGVDPTN ESGERRITPEYLVKIYKEIVIPITKEVEVEYLLRRLEE" gene complement(675977..676882) /gene="JID1" /locus_tag="YPR061C" mRNA complement(675977..676882) /gene="JID1" /locus_tag="YPR061C" /product="Jid1p" CDS complement(675977..676882) /gene="JID1" /locus_tag="YPR061C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:17054397]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:19682992]" /note="Probable Hsp40p co-chaperone; has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae" /codon_start=1 /product="Jid1p" /protein_id="DAA11482.1" /db_xref="SGD:S000006265" /translation="MLHHKFVYPFLFKWHLSCVEKCPPQITFIAKYATANDKNGNRKL TIRDEQWPELADPTPYDIFGIPKAGSGNPKLDKKSLKKKYHRYVKLYHPDHSDNIQIF SSEKVTNSDSKSPLLLTSSEKLHRFKVISQAYDILCDPKKKIVYDTTRQGWTTSYSPR SNVNTENYQYAGSYGYHSNAQYEYWNAGTWEDANSMKNERIQENINPWTVIGIICGLA ICIEGTALLAKIQESLSKAEFTHDESGLHLIQSYTNYGLDTDKFSRLRRFLWFRTWGL YKSKEDLDREAKINEEMIRKLKAAK" gene 677165..677641 /gene="FCY1" /locus_tag="YPR062W" mRNA 677165..677641 /gene="FCY1" /locus_tag="YPR062W" /product="cytosine deaminase" CDS 677165..677641 /gene="FCY1" /locus_tag="YPR062W" /EC_number="3.5.4.1" /experiment="EXISTENCE:direct assay:GO:0004131 cytosine deaminase activity [PMID:9000374|PMID:15535715]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0008655 pyrimidine-containing compound salvage [PMID:9000374]" /experiment="EXISTENCE:mutant phenotype:GO:0019858 cytosine metabolic process [PMID:9000374]" /experiment="EXISTENCE:mutant phenotype:GO:0046087 cytidine metabolic process [PMID:10501935]" /note="Cytosine deaminase; zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)" /codon_start=1 /product="cytosine deaminase" /protein_id="DAA11483.1" /db_xref="SGD:S000006266" /translation="MVTGGMASKWDQKGMDIAYEEAALGYKEGGVPIGGCLINNKDGS VLGRGHNMRFQKGSATLHGEISTLENCGRLEGKVYKDTTLYTTLSPCDMCTGAIIMYG IPRCVVGENVNFKSKGEKYLQTRGHEVVVVDDERCKKIMKQFIDERPQDWFEDIGE" gene complement(677812..678320) /locus_tag="YPR063C" mRNA complement(join(677812..678193,678280..678320)) /locus_tag="YPR063C" /product="hypothetical protein" CDS complement(join(677812..678193,678280..678320)) /locus_tag="YPR063C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /note="ER-localized hypothetical protein" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11484.1" /db_xref="SGD:S000006267" /translation="MTLNNVARPDLCVSYKKIAPPKGLYSATPSISGVVNQSMPMAAI FLRNKFIAWFSLIQSVHYYLNTDEDIIVAYKENKAPSPMDQPPAIKLFMSLIGLCVCY MNLVFPQQIAQPSSSGSKGNTETTIETTTEVETETAKQ" gene 678951..679370 /locus_tag="YPR064W" mRNA 678951..679370 /locus_tag="YPR064W" /product="hypothetical protein" CDS 678951..679370 /locus_tag="YPR064W" /note="hypothetical protein; conserved among S. cerevisiae strains; YPR064W is not an essential gene" /codon_start=1 /product="hypothetical protein" /protein_id="DAA80346.1" /db_xref="SGD:S000006268" /translation="MKSCVLSNYVEGLEIIVCGYRNRLLFPFRATQVQAYFKVFSFFF FLLLTLGAAAAAKPTSERQVIFGSADKSPGYHWPVEVSAAWNYRELLCKTIGNLVGKP CSRTWRLLTKKKRAYCCCLFCCSSSYCLAGVLCVFCV" gene 679693..680799 /gene="ROX1" /locus_tag="YPR065W" /gene_synonym="REO1" mRNA 679693..680799 /gene="ROX1" /locus_tag="YPR065W" /gene_synonym="REO1" /product="Rox1p" CDS 679693..680799 /gene="ROX1" /locus_tag="YPR065W" /gene_synonym="REO1" /experiment="EXISTENCE:curator inference:GO:0000785 chromatin [PMID:10446242|PMID:10487921|PMID:7565763|PMID:8413209]" /experiment="EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:10487921]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:10446242|PMID:7565763]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:10446242|PMID:8413209]" /experiment="EXISTENCE:genetic interaction:GO:0071470 cellular response to osmotic stress [PMID:23435728]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10446242|PMID:1588959|PMID:16835445|PMID:9388292|PMI D:12051835|PMID:2546055|PMID:12095998|PMID:3062365|PMID:10 487921|PMID:21299653|PMID:2847035]" /experiment="EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:10446242]" /experiment="EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:14665463]" /experiment="EXISTENCE:mutant phenotype:GO:0036295 cellular response to increased oxygen levels [PMID:9388292|PMID:10446242|PMID:2847035|PMID:12051835|PMI D:1588959|PMID:12095998|PMID:2546055|PMID:3062365|PMID:104 87921|PMID:16835445]" /experiment="EXISTENCE:mutant phenotype:GO:0071470 cellular response to osmotic stress [PMID:23435728]" /experiment="EXISTENCE:mutant phenotype:GO:0071472 cellular response to salt stress [PMID:21299653]" /note="Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance" /codon_start=1 /product="Rox1p" /protein_id="DAA11485.1" /db_xref="SGD:S000006269" /translation="MNPKSSTPKIPRPKNAFILFRQHYHRILIDEWTAQGVEIPHNSN ISKIIGTKWKGLQPEDKAHWENLAEKEKLEHERKYPEYKYKPVRKSKKKQLLLKEIEQ QQQQQQKEQQQQKQSQPQLQQPFNNNIVLMKRAHSLSPSSSVSSSNSYQFQLNNDLKR LPIPSVNTSNYMVSRSLSGLPLTHDKTARDLPQLSSQLNSIPYYSAPHDPSTRHHYLN VAQAQPRANSTPQLPFISSIINNSSQTPVTTTTTSTTTATSSPGKFSSSPNSSVLENN RLNSINNSNQYLPPPLLPSLQDFQLDQYQQLKQMGPTYIVKPLSHTRNNLLSTTTPTH HHIPHIPNQNIPLHQIINSSNTEVTAKTSLVSPK" gene 681213..682112 /gene="UBA3" /locus_tag="YPR066W" mRNA 681213..682112 /gene="UBA3" /locus_tag="YPR066W" /product="NEDD8-activating protein UBA3" CDS 681213..682112 /gene="UBA3" /locus_tag="YPR066W" /EC_number="6.2.1.64" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019781 NEDD8 activating enzyme activity [PMID:9545234]" /experiment="EXISTENCE:direct assay:GO:0045116 protein neddylation [PMID:9545234]" /experiment="EXISTENCE:mutant phenotype:GO:0045116 protein neddylation [PMID:9545234]" /note="Protein that activates Rub1p (NEDD8) before neddylation; acts together with Ula1p; may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern" /codon_start=1 /product="NEDD8-activating protein UBA3" /protein_id="DAA11486.1" /db_xref="SGD:S000006270" /translation="MDCKILVLGAGGLGCEILKNLTMLSFVKQVHIVDIDTIELTNLN RQFLFCDKDIGKPKAQVAAQYVNTRFPQLEVVAHVQDLTTLPPSFYKDFQFIISGLDA IEPRRFINETLVKLTLESNYEICIPFIDGGTEGLKGHVKTIIPGITACWECSIDTLPS QQDTVPMCTIANNPRCIEHVVEYVSTIQYPDLNIESTADMEFLLEKCCERAAQFSIST EKLSTSFILGIIKSIIPSVSTTNAMVAATCCTQMVKIYNDLIDLENGNNFTLINCSEG CFMYSFKFERLPDCTVCSNSNSN" gene 682220..682777 /gene="ISA2" /locus_tag="YPR067W" mRNA 682220..682777 /gene="ISA2" /locus_tag="YPR067W" /product="Isa2p" CDS 682220..682777 /gene="ISA2" /locus_tag="YPR067W" /experiment="EXISTENCE:direct assay:GO:0005506 iron ion binding [PMID:21987576]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:10805735]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:10913600]" /experiment="EXISTENCE:genetic interaction:GO:0009102 biotin biosynthetic process [PMID:17259550]" /experiment="EXISTENCE:genetic interaction:GO:0016226 iron-sulfur cluster assembly [PMID:10805735]" /experiment="EXISTENCE:mutant phenotype:GO:0009102 biotin biosynthetic process [PMID:17259550]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:10805735|PMID:10913600]" /experiment="EXISTENCE:mutant phenotype:GO:0044572 [4Fe-4S] cluster assembly [PMID:21987576]" /note="Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations" /codon_start=1 /product="Isa2p" /protein_id="DAA11487.1" /db_xref="SGD:S000006271" /translation="MQAKLLFTRLNFRRPSTTLRQFPLTCFLFHSKAFYSDLVTKEPL ITPKRIINKTPGLNLSISERASNRLAEIYRNSKENLRISVESGGCHGFQYNLTLEPAT KPDIKNDVKDKEFSDDLDDDDSKDIIYVLPEDKGRVIIDSKSLNILNNTTLTYTNELI GSSFKIINGSLKSSCGCGSSFDIEN" gene complement(682941..684353) /gene="HOS1" /locus_tag="YPR068C" /gene_synonym="CST3" mRNA complement(682941..684353) /gene="HOS1" /locus_tag="YPR068C" /gene_synonym="CST3" /product="histone deacetylase" CDS complement(682941..684353) /gene="HOS1" /locus_tag="YPR068C" /gene_synonym="CST3" /EC_number="3.5.1.98" /experiment="EXISTENCE:direct assay:GO:0033558 protein lysine deacetylase activity [PMID:20832720|PMID:20797861]" /experiment="EXISTENCE:mutant phenotype:GO:0033558 protein lysine deacetylase activity [PMID:20832720|PMID:20797861]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17706600]" /experiment="EXISTENCE:physical interaction:GO:0000118 histone deacetylase complex [PMID:22543816]" /note="Class I histone deacetylase (HDAC) family member; deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex" /codon_start=1 /product="histone deacetylase" /protein_id="DAA11488.1" /db_xref="SGD:S000006272" /translation="MSKLVISTSIFQSQVADLLPCNNHQKSQLTYSLINAYDLLQHFD EVLTFPYARKDDLLEFHSKSYIDYLINGRFNKMMAQDVNNPMVESKWSELSELADNWN EKIDYNPSQDLQRFTTRENLYNYYLNHSQALENNMDCINNSEVPTNDKPTDTYILNSE TKQYNLEGDCPIFSYLPMYCQVITGATLNLLDHLSPTERLIGINWDGGRHHAFKQRAS GFCYINDVVLLIQRLRKAKLNKITYVDFDLHHGDGVEKAFQYSKQIQTISVHLYEPGF FPGTGSLSDSRKDKNVVNIPLKHGCDDNYLELIASKIVNPLIERHEPEALIIECGGDG LLGDRFNEWQLTIRGLSRIIINIMKSYPRAHIFLLGGGGYNDLLMSRFYTYLTWCVTK QFSNLRCGDNNSFQIDPFDVCDGDDSEQFIREHDLVEMYNEENYQYWIYEMEGSSRMK MLRNDNKDRDMVELMKFYEL" rep_origin 684389..684637 /note="ARS1624; Autonomously Replicating Sequence" /db_xref="SGD:S000118420" gene complement(684556..685437) /gene="SPE3" /locus_tag="YPR069C" mRNA complement(684556..685437) /gene="SPE3" /locus_tag="YPR069C" /product="spermidine synthase" CDS complement(684556..685437) /gene="SPE3" /locus_tag="YPR069C" /EC_number="2.5.1.16" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004766 spermidine synthase activity [PMID:9073064]" /experiment="EXISTENCE:mutant phenotype:GO:0008295 spermidine biosynthetic process [PMID:9073064]" /experiment="EXISTENCE:mutant phenotype:GO:0015940 pantothenate biosynthetic process [PMID:11154694]" /note="Spermidine synthase; involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells" /codon_start=1 /product="spermidine synthase" /protein_id="DAA11489.1" /db_xref="SGD:S000006273" /translation="MAQEITHPTIVDGWFREISDTMWPGQAMTLKVEKVLHHEKSKYQ DVLIFKSTTYGNVLVLDNVIQATERDEFAYQEMIAHLALNSHPNPKKVLVIGGGDGGV LREVVKHDSVEEAWLCDIDEAVIRLSKEYLPEMAASYSHPKVKTHIGDGFQFLRDYQN TFDVIITDSSDPEGPAETLFQKEYFQLLNSALTEKGVITTQAESMWIHLPIIKDLKKA CSEVFPVAEYSFVTIPTYPTGTIGFMVCSKDKTCNVKKPLREISDEKEAELYRYYNKK IHEASFVLPTWAAKELN" gene 685898..687598 /gene="MED1" /locus_tag="YPR070W" mRNA 685898..687598 /gene="MED1" /locus_tag="YPR070W" /product="Med1p" CDS 685898..687598 /gene="MED1" /locus_tag="YPR070W" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9892641]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9892641]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation" /codon_start=1 /product="Med1p" /protein_id="DAA11490.1" /db_xref="SGD:S000006274" /translation="MVEGDSYVETLDSMIELFKDYKPGSITLENITRLCQTLGLESFT EELSNELSRLSTASKIIVIDVDYNKKQDRIQDVKLVLASNFDNFDYFNQRDGEHEKSN ILLNSLTKYPDLKAFHNNLKFLYLLDAYSHIESDSTSHNNGSSDKSLDSSNASFNNQG KLDLFKYFTELSHYIRQCFQDNCCDFKVRTNLNDKFGIYILTQGINGKEVPLAKIYLE ENKSDSQYRFYEYIYSQETKSWINESAENFSNGISLVMEIVANAKESNYTDLIWFPED FISPELIIDKVTCSSNSSSSPPIIDLFSNNNYNSRIQLMNDFTTKLINIKKFDISNDN LDLISEILKWVQWSRIVLQNVFKLVSTPSSNSNSSELEPDYQAPFSTSTKDKNSSTSN TEPIPRSNRHGSVVEASRRRRSSTNKSKRPSITEAMMLKEEGLQQFNLHEILSEPAIE EENGDSIKEHSTTMDGANDLGFTASVSNQENAGTDIVMEDHGVLQGTSQNYGTATADD ADIEMKDVSSKPSKPESSVLQLIVSEDHIILDTISECNLYDDVKCWSKFIEKFQDIVS " gene 688172..688807 /locus_tag="YPR071W" mRNA 688172..688807 /locus_tag="YPR071W" /product="hypothetical protein" CDS 688172..688807 /locus_tag="YPR071W" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Putative membrane protein; YPR071W is not an essential gene; YPR071W has a paralog, YIL029C, that arose from a single-locus duplication" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11491.1" /db_xref="SGD:S000006275" /translation="MQNGTEDKSNIPARSNDDVLPPLAVRLTMKVMRLIFIGKMFAYS FVPFPPFKLLTFDNTVGWFVAYSAIVSIWGFAVWMERGYRHKINLLPPRCTKIRCSRC NTRIRSPNWFKYKNWLYFFLLYVSLTTSNLIIQLASFMTEMSRRGISVPGTKDPGKRD YLGLIIPMRFIGAFIHYMTANLFKEYYLHNGPLEKNDRPSTDEKTSENETL" gene 689565..689646 /gene="SUP16" /locus_tag="YNCP0012W" tRNA 689565..689646 /gene="SUP16" /locus_tag="YNCP0012W" /product="tRNA-Ser" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Serine tRNA (tRNA-Ser), predicted by tRNAscan-SE analysis; can mutate to suppress ochre nonsense mutations" /db_xref="SGD:S000006736" gene 690107..691789 /gene="NOT5" /locus_tag="YPR072W" mRNA 690107..691789 /gene="NOT5" /locus_tag="YPR072W" /product="CCR4-NOT core subunit NOT5" CDS 690107..691789 /gene="NOT5" /locus_tag="YPR072W" /experiment="EXISTENCE:direct assay:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:21406554]" /experiment="EXISTENCE:mutant phenotype:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:26952104]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:11404327]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16926149]" /experiment="EXISTENCE:mutant phenotype:GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA [PMID:15706350]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:26952104]" /experiment="EXISTENCE:physical interaction:GO:0030015 CCR4-NOT core complex [PMID:10490603]" /note="Component of the CCR4-NOT core complex, involved in mRNA decapping; involved intranscription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not5p and Not3p is mutated in cancers" /codon_start=1 /product="CCR4-NOT core subunit NOT5" /protein_id="DAA11492.1" /db_xref="SGD:S000006276" /translation="MSQRKLQQDIDKLLKKVKEGIEDFDDIYEKFQSTDPSNSSHREK LESDLKREIKKLQKHRDQIKTWLSKEDVKDKQSVLMTNRRLIENGMERFKSVEKLMKT KQFSKEALTNPDIIKDPKELKKRDQVLFIHDCLDELQKQLEQYEAQENEEQTERHEFH IANLENILKKLQNNEMDPEPVEEFQDDIKYYVENNDDPDFIEYDTIYEDMGCEIQPSS SNNEAPKEGNNQTSLSSIRSSKKQERSPKKKAPQRDVSISDRATTPIAPGVESASQSI SSTPTPVSTDTPLHTVKDDSIKFDNSTLGTPTTHVSMKKKESENDSEQQLNFPPDRTD EIRKTIQHDVETNAAFQNPLFNDELKYWLDSKRYLMQPLQEMSPKMVSQLESSLLNCP DSLDADSPCLYTKPLSLPHPTSIFFPNEPIRFVYPYDVPLNLTNNENDTDNKFGKDSK AKSKKDDDIYSRTSLARIFMKFDLDTLFFIFYHYQGSYEQFLAARELFKNRNWLFNKV DRCWYYKEIEKLPPGMGKSEEESWRYFDYKKSWLARRCGNDFVYNEEDFEKL" gene complement(691933..692418) /gene="LTP1" /locus_tag="YPR073C" mRNA complement(691933..692418) /gene="LTP1" /locus_tag="YPR073C" /product="tyrosine protein phosphatase LTP1" CDS complement(691933..692418) /gene="LTP1" /locus_tag="YPR073C" /EC_number="3.1.3.2" /EC_number="3.1.3.48" /experiment="EXISTENCE:direct assay:GO:0004725 protein tyrosine phosphatase activity [PMID:7629177|PMID:15358193]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006470 protein dephosphorylation [PMID:7629177]" /experiment="EXISTENCE:mutant phenotype:GO:0004725 protein tyrosine phosphatase activity [PMID:7629177]" /note="Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine" /codon_start=1 /product="tyrosine protein phosphatase LTP1" /protein_id="DAA11493.1" /db_xref="SGD:S000006277" /translation="MTIEKPKISVAFICLGNFCRSPMAEAIFKHEVEKANLENRFNKI DSFGTSNYHVGESPDHRTVSICKQHGVKINHKGKQIKTKHFDEYDYIIGMDESNINNL KKIQPEGSKAKVCLFGDWNTNDGTVQTIIEDPWYGDIQDFEYNFKQITYFSKQFLKKE L" gene complement(692796..694838) /gene="TKL1" /locus_tag="YPR074C" mRNA complement(692796..694838) /gene="TKL1" /locus_tag="YPR074C" /product="transketolase TKL1" CDS complement(692796..694838) /gene="TKL1" /locus_tag="YPR074C" /EC_number="2.2.1.1" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:8299150]" /experiment="EXISTENCE:mutant phenotype:GO:0004802 transketolase activity [PMID:8226984]" /experiment="EXISTENCE:mutant phenotype:GO:0006098 pentose-phosphate shunt [PMID:8299150]" /note="Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication" /codon_start=1 /product="transketolase TKL1" /protein_id="DAA11494.1" /db_xref="SGD:S000006278" /translation="MTQFTDIDKLAVSTIRILAVDTVSKANSGHPGAPLGMAPAAHVL WSQMRMNPTNPDWINRDRFVLSNGHAVALLYSMLHLTGYDLSIEDLKQFRQLGSRTPG HPEFELPGVEVTTGPLGQGISNAVGMAMAQANLAATYNKPGFTLSDNYTYVFLGDGCL QEGISSEASSLAGHLKLGNLIAIYDDNKITIDGATSISFDEDVAKRYEAYGWEVLYVE NGNEDLAGIAKAIAQAKLSKDKPTLIKMTTTIGYGSLHAGSHSVHGAPLKADDVKQLK SKFGFNPDKSFVVPQEVYDHYQKTILKPGVEANNKWNKLFSEYQKKFPELGAELARRL SGQLPANWESKLPTYTAKDSAVATRKLSETVLEDVYNQLPELIGGSADLTPSNLTRWK EALDFQPPSSGSGNYSGRYIRYGIREHAMGAIMNGISAFGANYKPYGGTFLNFVSYAA GAVRLSALSGHPVIWVATHDSIGVGEDGPTHQPIETLAHFRSLPNIQVWRPADGNEVS AAYKNSLESKHTPSIIALSRQNLPQLEGSSIESASKGGYVLQDVANPDIILVATGSEV SLSVEAAKTLAAKNIKARVVSLPDFFTFDKQPLEYRLSVLPDNVPIMSVEVLATTCWG KYAHQSFGIDRFGASGKAPEVFKFFGFTPEGVAERAQKTIAFYKGDKLISPLKKAF" rep_origin 695461..695574 /note="ARS1625; Autonomously Replicating Sequence" /db_xref="SGD:S000118421" gene complement(695737..696819) /gene="OPY2" /locus_tag="YPR075C" mRNA complement(695737..696819) /gene="OPY2" /locus_tag="YPR075C" /product="Opy2p" CDS complement(695737..696819) /gene="OPY2" /locus_tag="YPR075C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16543225|PMID:22842922]" /experiment="EXISTENCE:genetic interaction:GO:0007231 osmosensory signaling pathway [PMID:16543225]" /experiment="EXISTENCE:genetic interaction:GO:0072659 protein localization to plasma membrane [PMID:22904036|PMID:17627274]" /experiment="EXISTENCE:mutant phenotype:GO:0000751 mitotic cell cycle G1 arrest in response to pheromone [PMID:9383053]" /experiment="EXISTENCE:mutant phenotype:GO:1900436 positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [PMID:22904036]" /experiment="EXISTENCE:physical interaction:GO:0007231 osmosensory signaling pathway [PMID:16543225]" /note="Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress" /codon_start=1 /product="Opy2p" /protein_id="DAA11495.1" /db_xref="SGD:S000006279" /translation="MSSSSKASASSSLSSTATSSTSATRGSDGCVVCDSTASCPVCAS GEYCVMTSLTCDKCPSTYCAKQSDSQLSSLSSSSSSSSSSNSNEKTSLIVGFTVGIVG GAMLIALVALYFINKRYWKPKRQKNKALKLEEASQSYGNEEEYFDDEDDDDEDDEDDG GMRKDESHTLFNTSLVPPTLNVPGNRSSASTTRTRASNILPIAYIPGVTSGLSTDKLQ SKLRSSSKRQNAAGDIRSHITLGSSILDGLDDEDDEHNQVLNKDADDNLITAIRAKPK LVQIAEEESDKEIQDLDVIEEQTEADDLSHMAKSEASHGNNDEDDDEEGSFILDLEIP ESIRESTQGSRTESPFEDKFEIHDER" gene complement(697147..698265) /locus_tag="YPR078C" mRNA complement(697147..698265) /locus_tag="YPR078C" /product="hypothetical protein" CDS complement(697147..698265) /locus_tag="YPR078C" /note="hypothetical protein; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11496.1" /db_xref="SGD:S000006282" /translation="MQTISGVLPTVLSPSELRSDDERTFQFDEEAEITTHLTESEDLR RLINETAQLGVRVDHIHDKTDQEIARLEKVIKEVTESDTFFRSCSGWFKTNKNFSDSE SSSNTQLKSLSQLHGRYDRDWRQRLNKWFRKNKSKLALPSDNNLEEVNDDKVYGYGED LMERGKTPYFSDIDDFMNGLNIISPLTPDDFENDDTLVKIDETCQIHSASEPEKTSIS PTFGKNIKKELVTDDTESIISGPPLQENKKTLLKYRYVRTSLDMLGSEKSSSKNNSGG MFRIFHKSANFGDKNQENVPRVWDTLRNNLGREIYLLQGRFKKWTTKHQNLKKGQPCK DEDAVTVPLPSSDPGKETQLETKLCFVPEPGDQPLVQA" gene 698869..700014 /gene="MRL1" /locus_tag="YPR079W" mRNA 698869..700014 /gene="MRL1" /locus_tag="YPR079W" /product="Mrl1p" CDS 698869..700014 /gene="MRL1" /locus_tag="YPR079W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:11470415]" /experiment="EXISTENCE:genetic interaction:GO:0005048 signal sequence binding [PMID:11470415]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:11470415]" /note="Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="Mrl1p" /protein_id="DAA11497.1" /db_xref="SGD:S000006283" /translation="MLKRSSLIYLSCVLIITIPILLHVYNGPGLSHEANEHRASHKQK RTLANPDKPKSENDEDLFCAVTNPVTGSYIDLSQLSSTPNKLREGQKQISGNNKHESS KTKWSVRGWGYDTNFTLGICSSPVGEAESQQLSNLTGAFYVDQLNENNLVSIGDFSTR PALVGGSTAKKLTLKYENGSMCPNGKDKKATLLNFVCDKEIQSKAQISYIGNLHNCSY FFEVRSIHACPTSNKKNEVNVLGIFIGIFAIFFLVEFAGRRWIYAKLNRHLKNDDELH DISPSLNEQPHWDLIEDGSRWSKFFNGIIKTTRRFTKSLMRSLVRGRNSRQGGIRLRS SPSASSSSLANREFFRDMEAQNEIIDSLDINSHTTESDHPTLADNSV" gene 700594..701970 /gene="TEF1" /locus_tag="YPR080W" mRNA 700594..701970 /gene="TEF1" /locus_tag="YPR080W" /product="translation elongation factor EF-1 alpha" CDS 700594..701970 /gene="TEF1" /locus_tag="YPR080W" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:25561732]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:17925388]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:20032305]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0019003 GDP binding [PMID:17925388]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:25561732]" /experiment="EXISTENCE:direct assay:GO:0051017 actin filament bundle assembly [PMID:19095653|PMID:16116436|PMID:25561732]" /experiment="EXISTENCE:direct assay:GO:1904408 melatonin binding [PMID:31708896]" /experiment="EXISTENCE:genetic interaction:GO:0006409 tRNA export from nucleus [PMID:17203074|PMID:10766739]" /experiment="EXISTENCE:mutant phenotype:GO:0003746 translation elongation factor activity [PMID:10514524]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:17203074|PMID:10766739]" /experiment="EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:10514524]" /experiment="EXISTENCE:mutant phenotype:GO:0051017 actin filament bundle assembly [PMID:16116436]" /experiment="EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]" /note="Translational elongation factor EF-1 alpha; GTP-bound active form, binds to and delivers aminoacylated tRNA to the A-site of ribosomes for elongation of nascent polypeptides; moonlighting function as an actin binding and bundling protein; association with GTPase Rho1p on the vacuolar membrane may facilitate F-actin remodeling; involved in tRNA re-export from the nucleus" /codon_start=1 /product="translation elongation factor EF-1 alpha" /protein_id="DAA11498.1" /db_xref="SGD:S000006284" /translation="MGKEKSHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEK EAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYQVTVIDAPGHRDFIKNM ITGTSQADCAILIIAGGVGEFEAGISKDGQTREHALLAFTLGVRQLIVAVNKMDSVKW DESRFQEIVKETSNFIKKVGYNPKTVPFVPISGWNGDNMIEATTNAPWYKGWEKETKA GVVKGKTLLEAIDAIEQPSRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKPGMVV TFAPAGVTTEVKSVEMHHEQLEQGVPGDNVGFNVKNVSVKEIRRGNVCGDAKNDPPKG CASFNATVIVLNHPGQISAGYSPVLDCHTAHIACRFDELLEKNDRRSGKKLEDHPKFL KSGDAALVKFVPSKPMCVEAFSEYPPLGRFAVRDMRQTVAVGVIKSVDKTEKAAKVTK AAQKAAKK" gene complement(702114..703970) /gene="GRS2" /locus_tag="YPR081C" mRNA complement(702114..703970) /gene="GRS2" /locus_tag="YPR081C" /product="putative glycine--tRNA ligase" CDS complement(702114..703970) /gene="GRS2" /locus_tag="YPR081C" /EC_number="6.1.1.14" /experiment="EXISTENCE:direct assay:GO:0004820 glycine-tRNA ligase activity [PMID:21877692|PMID:22438917]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:21877692]" /experiment="EXISTENCE:genetic interaction:GO:0004820 glycine-tRNA ligase activity [PMID:22438917]" /experiment="EXISTENCE:genetic interaction:GO:0006426 glycyl-tRNA aminoacylation [PMID:22438917]" /note="Glycine-tRNA synthetase, not expressed under normal growth conditions; expression is induced under heat, oxidative, pH, or ethanol stress conditions; more stable than the major glycine-tRNA synthetase Grs1p at 37 deg C; GRS2 has a paralog, GRS1, that arose from the whole genome duplication" /codon_start=1 /product="putative glycine--tRNA ligase" /protein_id="DAA11499.1" /db_xref="SGD:S000006285" /translation="MPLMSNSERDKLESTLRRRFFYTPSFEIYGGVSGLFDLGPPGCQ LQNNLIRLWREHFIMEENMLQVDGPMLTPYDVLKTSGHVDKFTDWMCRNPKTGEYYRA DHLIEQTLKKRLLDKDVNPQDMKNMEKILTTIDGFSGPELNLVMQEYNINDPVTNDVL DALTSFNLMFETKIGASGQLKAFLRPETAQGQFLNFNKLLEINQGKIPFASASIGKSF RNEISPRSGLLRVREFLMAEIEHFVDPLNKSHAKFNEVLNEEIPLLSRRLQESGEVQL PVKMTIGEAVNSGMVENETLGYFMARVHQFLLNIGINKDKFRFRQHLKNEMAHYATDC WDGEILTSYGWIECVGCADRAAFDLTVHSKKTGRSLTVKQKLDTPKERTEWVVEVNKK FFGSKFKQKAKLIESVLSKFSQDELIRRHEELEKNGEFTCQVNGQIVKLDSSLVTIKM KTTLQHIREYIPNVIEPSFGLGRIIYCIFDHCFQVRVDSESRGFFSFPLQIAPIKVFV TTISNNDGFPAILKRISQALRKREIYFKIDDSNTSIGKKYARNDELGTPFGITIDFET IKDQTVTLRERNSMRQVRGTITDVISTIDKMLHNPDESDWDKSTFGLSPVKI" gene complement(704225..704656) /gene="DIB1" /locus_tag="YPR082C" /gene_synonym="SNU16" mRNA complement(704225..704656) /gene="DIB1" /locus_tag="YPR082C" /gene_synonym="SNU16" /product="U4/U6-U5 snRNP complex subunit DIB1" CDS complement(704225..704656) /gene="DIB1" /locus_tag="YPR082C" /gene_synonym="SNU16" /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720284]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419|PMID:10377396]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:10610776|PMID:11720284]" /note="17-kDa component of the U4/U6aU5 tri-snRNP; plays an essential role in pre-mRNA splicing; human ortholog TXNL4A (the human U5-specific 15-kDa protein) complements yeast dib1 null mutant" /codon_start=1 /product="U4/U6-U5 snRNP complex subunit DIB1" /protein_id="DAA11500.1" /db_xref="SGD:S000006286" /translation="MASVLLPQLRTGWHVDQAIVTETKRLVVIRFGRKNDRQCMIMDE LLSSIAERVRNFAVIYLCDIDEVSDFDEMYELTDPMTVMFFYHNKHMMCDFGTGNNNK LNFIVDDKQEMIDILETIFRGARKNKGLVVSPYDYNHKRVS" gene 704854..706593 /gene="MDM36" /locus_tag="YPR083W" mRNA 704854..706593 /gene="MDM36" /locus_tag="YPR083W" /product="Mdm36p" CDS 704854..706593 /gene="MDM36" /locus_tag="YPR083W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:20505073]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:20505073]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:23641071]" /experiment="EXISTENCE:mutant phenotype:GO:0000266 mitochondrial fission [PMID:20505073]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:11907266]" /experiment="EXISTENCE:mutant phenotype:GO:0048312 intracellular distribution of mitochondria [PMID:20505073]" /note="Mitochondrial protein; required for normal mitochondrial morphology and inheritance; component of the mitochondria-ER-cortex-anchor (MECA); interacts with Num1p to link the ER and mitochondria at the cell cortex; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission" /codon_start=1 /product="Mdm36p" /protein_id="DAA11501.1" /db_xref="SGD:S000006287" /translation="MDENGTVKPGYELKGLNSGNSRSNMDKDPIVSKFHRAGLNDSAD EEDTDINGNRNTSWITSMISEEKRKVEGKSMLNDEEDLHLSKATLNKCDALVKILADI IKLEFVIHQSWYIRSLHKSVLIQFEVETSGGNKNSAGDSGDDDDDNHNGNLDDSFYKD LSLKCIKKCEKSSLALESLSRDIDQIRDFIMSNTIEDNRVDRLLQNSMTLLLECWIYS MKRLRRLRMKIAGIFVRSKLLLIDHELVTIWHFLQEQNEHETVNNENELKLAETIKSY RAFIKIFIQQLEDSESGSPSSSLFEECLHVFLDIESMYNSLNLNWLLNENKALQERLL SPSSTSENDHTNNLPVIDETKEIEDISSFVNSIVDASMLTHDLTPINSSDSDNLSNGE IDRLDGRRLSSSTSDMSLMMQRTSLQKQLPSLLTAFNNARRLEQELQNACKVNDNKHS TKDTDSNIRRNEHAMSSSVSSIISQNSTLASPSPPMSSSFISTAPSQSSSRMSTLPLS PSSSLLESQSQTLKNNMSQWLNQSRSGLNGTKLIPTNHIGFHSNVLNTLYGIGGGPVS KSYKSNQPSSQNT" gene 706972..708342 /locus_tag="YPR084W" mRNA 706972..708342 /locus_tag="YPR084W" /product="hypothetical protein" CDS 706972..708342 /locus_tag="YPR084W" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11502.1" /db_xref="SGD:S000006288" /translation="MSEKASEERPIRLAVLGGTSTGKTSLVSRLTVNIVHEVHYPTRN QTNWLFGFVPSSILARAILDEQAHERLCLRSPSSQTLEPIFPSPQVSKNVLLSPLVFQ ASTDNFQSVRLHNKSHSRRSLSLDKSDSPLYQTFSNDINSQSVPKIKADQLNVIEHFK LPLNYIPPTYAPIQIDIIDTPGFSPDNVVPFLEVSLFRNLGKSILHGLADEPRRPVST TSLLVASGASELNGKVDGYILVYSAVPELNHIGGPPEYGDDVMNTDTENVSDGGFELL KVIRNCILDAWTEFRNYEKRWEEGKEDDIYSLVYSLRHLWSKNSKEKSAKIEQLRSYN TKLKSIELDPSSPDSPPPCIIVCSHVNHELASPMLIEMGRQLATKWKYGFVGIDSMDD LNVDVAVSLLIKEISEKMKLLVSNSNGSSSSGNSSSIYNSHLMNDKKKNNNAGLNKNM LKKIIK" gene complement(708497..709828) /gene="ASA1" /locus_tag="YPR085C" mRNA complement(708497..709828) /gene="ASA1" /locus_tag="YPR085C" /product="Asa1p" CDS complement(708497..709828) /gene="ASA1" /locus_tag="YPR085C" /experiment="EXISTENCE:direct assay:GO:0110078 TTT Hsp90 cochaperone complex [PMID:19040720]" /note="Subunit of the TTT complex and regulator of telomere length; subunit of the TTT Hsp90 cochaperone complex that is involved in chromatin remodeling and telomeric chromatin regulation; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1" /codon_start=1 /product="Asa1p" /protein_id="DAA11503.1" /db_xref="SGD:S000006289" /translation="MRGFSNEIILKRTLTLSDFTLRYHKRGITALQVIKAPSVSNVPV LLSGDNYGYFVMWDLVTKRPITHIEIEGNSHIIAFWWVETTNVLYILSKDSMLRIFEL DSSTQLSIDLVRKLSQANKTDHLQWTKIYEMPINTLNFANFIIEAEVKPTKDNKSYRL VCCHTDDSETIDIYQIIEDSTFKLKRPFNNINFPRFLKQQNFLGISKDSKFGIIMRFA KLNDVIFLGYENGFVVGFKITFDEGLQRDIAELVHVSNDHYPNPILDMCVSGDELYSC STDDFITKYKIPVNLQLETKYLRDDALLIKCPSSLRVSEPSKVHLPLKNIGHIDKVKD DYLVVSSWSGMTIVYNMRTSEVEQTFVKSKNNLVVSDSSMGDLTNGSGSNTESSSKSH NYKVGAMTCLESFDVQSDGLRLGQLRRIKALAKCNWCLIGYEDGTIKLNKI" gene 710101..711138 /gene="SUA7" /locus_tag="YPR086W" /gene_synonym="SOH4" mRNA 710101..711138 /gene="SUA7" /locus_tag="YPR086W" /gene_synonym="SOH4" /product="transcription factor SUA7" CDS 710101..711138 /gene="SUA7" /locus_tag="YPR086W" /gene_synonym="SOH4" /experiment="EXISTENCE:direct assay:GO:0000993 RNA polymerase II complex binding [PMID:7935466]" /experiment="EXISTENCE:direct assay:GO:0001139 RNA polymerase II complex recruiting activity [PMID:10464320]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15888545]" /experiment="EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:10464320|PMID:15888545]" /experiment="EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:10464320]" /experiment="EXISTENCE:direct assay:GO:0097550 transcription preinitiation complex [PMID:22751016]" /experiment="EXISTENCE:direct assay:GO:2000679 positive regulation of transcription regulatory region DNA binding [PMID:8132551]" /experiment="EXISTENCE:mutant phenotype:GO:0001113 transcription open complex formation at RNA polymerase II promoter [PMID:19820686]" /experiment="EXISTENCE:mutant phenotype:GO:0001139 RNA polymerase II complex recruiting activity [PMID:10464320]" /experiment="EXISTENCE:mutant phenotype:GO:0001174 transcriptional start site selection at RNA polymerase II promoter [PMID:19820686]" /experiment="EXISTENCE:mutant phenotype:GO:0017025 TBP-class protein binding [PMID:10464320]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:9887099|PMID:10464320]" /experiment="EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:7935466]" /experiment="EXISTENCE:physical interaction:GO:0017025 TBP-class protein binding [PMID:15888545]" /note="Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II" /codon_start=1 /product="transcription factor SUA7" /protein_id="DAA11504.1" /db_xref="SGD:S000006290" /translation="MMTRESIDKRAGRRGPNLNIVLTCPECKVYPPKIVERFSEGDVV CALCGLVLSDKLVDTRSEWRTFSNDDHNGDDPSRVGEASNPLLDGNNLSTRIGKGETT DMRFTKELNKAQGKNVMDKKDNEVQAAFAKITMLCDAAELPKIVKDCAKEAYKLCHDE KTLKGKSMESIMAASILIGCRRAEVARTFKEIQSLIHVKTKEFGKTLNIMKNILRGKS EDGFLKIDTDNMSGAQNLTYIPRFCSHLGLPMQVTTSAEYTAKKCKEIKEIAGKSPIT IAVVSIYLNILLFQIPITAAKVGQTLQVTEGTIKSGYKILYEHRDKLVDPQLIANGVV SLDNLPGVEKK" gene complement(711403..713028) /gene="SRP54" /locus_tag="YPR088C" /gene_synonym="SRH1" mRNA complement(711403..713028) /gene="SRP54" /locus_tag="YPR088C" /gene_synonym="SRH1" /product="RNA-binding signal recognition particle subunit SRP54" CDS complement(711403..713028) /gene="SRP54" /locus_tag="YPR088C" /gene_synonym="SRH1" /EC_number="3.6.5.4" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005786 signal recognition particle, endoplasmic reticulum targeting [PMID:7925282]" /experiment="EXISTENCE:direct assay:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:10921896]" /experiment="EXISTENCE:direct assay:GO:0008312 7S RNA binding [PMID:14681587]" /experiment="EXISTENCE:mutant phenotype:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:1655273]" /note="Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain" /codon_start=1 /product="RNA-binding signal recognition particle subunit SRP54" /protein_id="DAA11505.1" /db_xref="SGD:S000006292" /translation="MVLADLGKRINSAVNNAISNTQDDFTTSVDVMLKGIVTALLESD VNIALVSKLRNNIRSQLLSENRSEKSTTNAQTKKLIQKTVFDELCKLVTCEGSEEKAF VPKKRKTNIIMFVGLQGSGKTTSCTKLAVYYSKRGFKVGLVCADTFRAGAFDQLKQNA IRARIPFYGSYTETDPAKVAEEGINKFKKEKFDIIIVDTSGRHHQEEELFQEMIEISN VIKPNQTIMVLDASIGQAAEQQSKAFKESSDFGAIILTKMDGHARGGGAISAVAATNT PIIFIGTGEHIHDLEKFSPKSFISKLLGIGDIESLFEQLQTVSNKEDAKATMENIQKG KFTLLDFKKQMQTIMKMGPLSNIAQMIPGMSNMMNQVGEEETSQKMKKMVYVLDSMTK EELESDGRMFIEEPTRMVRVAKGSGTSVFEVEMILMQQQMMARMAQTATQQQPGAPGA NARMPGMPNMPGMPNMPGMPNMPGMPKVTPQMMQQAQQKLKQNPGLMQNMMNMFGGGM GGGMGGGMPDMNEMMKMMQDPQMQQMAKQFGMG" gene 713275..715941 /locus_tag="YPR089W" /gene_synonym="YPR090W" mRNA 713275..715941 /locus_tag="YPR089W" /gene_synonym="YPR090W" /product="hypothetical protein" CDS 713275..715941 /locus_tag="YPR089W" /gene_synonym="YPR090W" /note="hypothetical protein; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11506.1" /db_xref="SGD:S000006293" /translation="MNSVWDDARIEDRTVDKPVGSSHAQEKLALVKSTLFKLDQEDRP ECDSWVQLVKLICDEDREEEFTTFKELLREVKNVNDKSVTGVALIHYIIVFDRADYIE LLHDNPSGAKLDLNLVDDIVGYTPLMWSFSLQRRNCCLELFNAFDEINFNMTNKAGLT AWDMVPPYSPLSEFLEQNNMFRYRTEVKHEIPQISQPKDTSLLMSNEDSTTKETFDNI DLQVAGLTLSPGANDNMFLDSDEKNMNHSQGAATLIDPTYTEDYHGTFDYDKLSPDQY LEFSDFDIPQILNLLISLPQKEPHMTTYPAGLIYQCIRYADHKIKSKPLVESLINLSL TKILTSVSSNGAAGLVSTEASLQAGDIVLQSYWLSCLSFLYYYLCRDDSFFKRHPSVL QELINTIHSIIIELTSSIHCRLISLIDSTLLAYTTIQDVKQTLYKRDWNFFKKRKQAK LLLKEKNRKQLKEQQKKELHRKSQGQENHEEEEGQQDGNDSDDRASTNDDNNSSVSLF YDKEILRHLYPPSFEEQMKPSPLKIVQIFGALSYVLNLHQTHPIFQQQCLSISVNWFA TTLFNKILKDKKKRSLSRAHAIQIRLNLSTLESWIQNNDFCVPKPMLIDDFMWQRFPM TLIRDVGEIDLSDPILRNVATYKPIDENNKDLIYDTSNSLFYYQPFHKIAQIHLEPVF QLLQWLQVATTLDSEESLISTMNLLPRITPVQLLKSMEKYNYELNENKFNSKLKKFLN NKIKDSKMSKADAYLQEHEIPYLVLPTIPEMTDLYSKGPDSHSFQPFLPGSIQDDVYE IHDVNFKQRQNEPQISRTNSGTSDFTGDEDKAQYETEGVGESIDINETVEPESNAFNV GNDDYFKELNIPSSTAQRPAWSNNDDMEQNPW" gene complement(716156..718468) /gene="NVJ2" /locus_tag="YPR091C" mRNA complement(716156..718468) /gene="NVJ2" /locus_tag="YPR091C" /product="Nvj2p" CDS complement(716156..718468) /gene="NVJ2" /locus_tag="YPR091C" /experiment="EXISTENCE:direct assay:GO:0005319 lipid transporter activity [PMID:28011845]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:22250200]" /experiment="EXISTENCE:direct assay:GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane [PMID:28011845]" /experiment="EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:22250200]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0035621 ER to Golgi ceramide transport [PMID:28011845]" /note="Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); involved in nonvesicular transfer of ceramides from ER to Golgi during ER stress; may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial-lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments" /codon_start=1 /product="Nvj2p" /protein_id="DAA11507.1" /db_xref="SGD:S000006295" /translation="MASLKVFLAVYLLGGITFLPLVLFTLYKIHLLYSNLKSASKKEL DHDTADEIDEKTRLLARDIDPEFKARKLEEQLGVKVFNKGWITVTKQYYYHSSEVAVI LKNSNNNKDSDTALQEQILQRTDLKKKQRFFAVLRHGNLFLYKDDSQNANLVHAISLQ NRFITIWPRFDELGKEELPDASLFTKRTCIAIFKNDLVSIDSKNHNVILPHFDPLTSA ESNNGDISTNDTTHEYQSQFHSSNQFFLYFDNNMDKEDWYYQLINASKNSNSLSTGLL DPNVSANAAHLKTKDMLQLIQDINSTENQLTTKWLNALLGRLFLSLQQTDTLNKFIHE KICKKLNKIKTPGFLDDLVVEKVDVGDSAPLFTSPELLELSPEGSTKIAIDVQYRGNL TIIIATKASINLGSRFKQREVSLQLSIKIKEFSGPLLFLIKPPPSNRIWYAFRTEPIM DFEIEPIVSSSKLSYNVVTNAIKSKFAEAVKESLVVPFMDDIVFYPTPNEVYRGGIWE EQDPEAAARARTAAAASDMNNTSAKEHLEALQEGGMKTQSRIKKALRPERKKENLKDL VDASGVATKTTTQTTVTTATNDDVSSSENSTKSRKYFKNSIKKIGRWYKDNVGNSSDT EDMDEIDVQDKKNDDSADERESDNPILTSNPKMISNRRPVPRRPSQPLNTLSPKLEGR KEKDTENFPVPPSASNMNASKMFANKENRKFSVSSNDSQNSLKNGDPHVKASKLESSQ AFVKKTSQNRFNDGFFKQDLEFEEQREPKL" gene complement(718700..718806) /gene="SNR51" /locus_tag="YNCP0013C" ncRNA complement(718700..718806) /ncRNA_class="snoRNA" /gene="SNR51" /locus_tag="YNCP0013C" /product="SNR51" /experiment="EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]" /experiment="EXISTENCE:curator inference:GO:0031428 box C/D methylation guide snoRNP complex [PMID:10024243]" /experiment="EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]" /experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]" /note="C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position U2729 and small subunit (SSU) rRNA at position A100" /db_xref="SGD:S000006442" gene complement(718887..719050) /gene="SNR70" /locus_tag="YNCP0014C" ncRNA complement(718887..719050) /ncRNA_class="snoRNA" /gene="SNR70" /locus_tag="YNCP0014C" /product="SNR70" /experiment="EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]" /experiment="EXISTENCE:curator inference:GO:0031428 box C/D methylation guide snoRNP complex [PMID:10024243]" /note="C/D box small nucleolar RNA (snoRNA); predicted to guide 2'-O-methylation of small subunit (SSU) rRNA at position C1639" /db_xref="SGD:S000006461" gene complement(719148..719242) /gene="SNR41" /locus_tag="YNCP0015C" ncRNA complement(719148..719242) /ncRNA_class="snoRNA" /gene="SNR41" /locus_tag="YNCP0015C" /product="SNR41" /experiment="EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:8674114|PMID:10024243]" /experiment="EXISTENCE:curator inference:GO:0031428 box C/D methylation guide snoRNP complex [PMID:8674114|PMID:10024243]" /experiment="EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]" /experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]" /note="C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of small subunit (SSU) rRNA at positions A541 and G1126" /db_xref="SGD:S000007305" gene complement(719558..720424) /gene="ASR1" /locus_tag="YPR093C" mRNA complement(719558..720424) /gene="ASR1" /locus_tag="YPR093C" /product="ubiquitin-protein ligase ASR1" CDS complement(719558..720424) /gene="ASR1" /locus_tag="YPR093C" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:19064926]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15117954]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15117954]" /experiment="EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:19064926]" /experiment="EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:25646695]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:19064926]" /experiment="EXISTENCE:mutant phenotype:GO:0045471 response to ethanol [PMID:15117954]" /note="Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein" /codon_start=1 /product="ubiquitin-protein ligase ASR1" /protein_id="DAA11508.1" /db_xref="SGD:S000006297" /translation="MEECPICLADDQEGEQFGCLNVCGHKFHLNCIREWHKYSINLKC PICRVESTHLEVGEGQHALSINLKMGFMIKNAIDYVGAETTNERNEDDTGEQDQEIEF LSERLRGTLVMDTIKIIQCSICGDTDVSRLSLYCQDCEAIYHETCLRGLACEVGDRNT WQECTDCRSNALLELRMGAISSQLASYDSRNSMIFAGELRDKHSVKTQQMYEQIRNAK HKIQMHVRRALDRYPLPLLRFKDAYKHVNKQVSRKLYRLSDNKYLPDQYDYDSLARTG VHTELLIYCHDE" gene 720637..720960 /gene="RDS3" /locus_tag="YPR094W" mRNA 720637..720960 /gene="RDS3" /locus_tag="YPR094W" /product="U2 snRNP complex subunit RDS3" CDS 720637..720960 /gene="RDS3" /locus_tag="YPR094W" /experiment="EXISTENCE:direct assay:GO:0000245 spliceosomal complex assembly [PMID:14517302]" /experiment="EXISTENCE:direct assay:GO:0005686 U2 snRNP [PMID:15565172|PMID:16314500]" /experiment="EXISTENCE:genetic interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:12871902]" /experiment="EXISTENCE:mutant phenotype:GO:0000245 spliceosomal complex assembly [PMID:14517302]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:12871902]" /experiment="EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:11943786]" /experiment="EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:16314500]" /note="Component of the SF3b subcomplex of the U2 snRNP; zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance" /codon_start=1 /product="U2 snRNP complex subunit RDS3" /protein_id="DAA11509.1" /db_xref="SGD:S000006298" /translation="MSRHQFDLIMCLKQPGVQTGLLCEKCDGKCPICDSYVRPKRKVR VCENCSFGKQAKNCIICNLNVGVNDAFYCWECCRLGKDKDGCPRILNLGSNRLDRHFE KKKKV" gene complement(721037..724717) /gene="SYT1" /locus_tag="YPR095C" mRNA complement(721037..724717) /gene="SYT1" /locus_tag="YPR095C" /product="Arf family guanine nucleotide exchange factor SYT1" CDS complement(721037..724717) /gene="SYT1" /locus_tag="YPR095C" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:20841378]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:10430582]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0032014 positive regulation of ARF protein signal transduction [PMID:20841378]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:10430582]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:10430582]" /experiment="EXISTENCE:mutant phenotype:GO:0032014 positive regulation of ARF protein signal transduction [PMID:20841378]" /experiment="EXISTENCE:mutant phenotype:GO:0034067 protein localization to Golgi apparatus [PMID:26966233]" /experiment="EXISTENCE:mutant phenotype:GO:0034976 response to endoplasmic reticulum stress [PMID:26966233]" /note="Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain" /codon_start=1 /product="Arf family guanine nucleotide exchange factor SYT1" /protein_id="DAA11510.1" /db_xref="SGD:S000006299" /translation="MNQSISSLIKLKFLQSHSNDKNGNKKGGSNVSTGIDKLRESESY RSPFLQLAEIQEHTNNDDDKLDVKECEPTKKHSKLSRIRRKMGRLDLNFRSANEKGSE DDEILVAQHLRNGQDPEEMPFKSENNIDSIEKVPKPDGERVTLTSSGSDNVKRNSKHA PFIPVKPALEKFPSSNRLSRDYRKSQEPTLFNGDRLVPTLPTVSRISTSSSVGSSTAA SRYFNPSKRAVVASSSSSSSSIKFNSLHAIPLDATPQIELAKQQDEISKRRFGRRRSR TVDVFDYINKNNTAKNKPPLSPSSFIRTIDEKNTNSLMQDPMGSRGPLLPDDANIISN DTDGAEASHPDHQVLSRSRSQSTSFVQGKGGKRKSIEDEGYHNKLGLPHGSGPTSVYN NKSNANSTITGMSRRSSSIVNALSSFVNLRSSSLSSSRQQHLQQQQQLQQKLDVSLED LPPVPAPEFSDSCKDFLIKLAPYGKFIGIILTEKDDEFKKNCLNYLLTNCFEFKNDPL DIALRKLLMFLELPKETQQIDRLIMAFSFAYYKAQKSYSKKKGIECPWSNADQVYFIA FSLLMLHTDYFNPNNKSKMTKHDFVDLVHNDKYSGGNEIPMAVLTYFYENVTAKESPK FNYFLMSPMALDDSILDKDAFDTNFAITLSSNSMYSPIDMIKRGSIIPKEASLSPIFY PLTNSISASGIAPSTAASCPPSTSGTINGANLGTANSNSNRPASNSISSYFSYNPSSS SSGNATLVQDDINVYSHIINDTLNEVNLFPEVSKYWNKNALKANLLRNEEHKYEKYYS IMNDTKGGYLRFHKSQLNKLNLPNFEILNDNSRSGCKNSDYKYCKILQMGAIMNLGMP SRKFSIVNSAKIHWKKEFAILTSLGLLICDKMDWINPQMMKDPKSGTTNYIIDFKSGF SFVPGSTIDVYNGLFADRERDSLGKSHFASLVLAYTEHHSTGSHTSNTTAASSSAKHN EGVFEPSSDEEDSITNSTDGTSSVSNGESDNDSVSSSDNQLSSNDSNEDYHSIKDEYP IFEDENADCLLYLHTCHRNFIWKCANKYERDNWIDSINLFSAYDGCYVEIGSIANTIC NKRKLTILQRMERLRSIKSAKWEKLKKFESTLMLMGKCVPISTKTKTDMINRIRQLAV RMDWLIYEIKRSELFVSIIKEVTRKQAEKNILEHGKGEEEGQGNNDDSDGIDDIEESF LFNENSLQVCVSDSSYDEYSNE" gene complement(724842..725144) /locus_tag="YPR096C" mRNA complement(724842..725144) /locus_tag="YPR096C" /product="hypothetical protein" CDS complement(724842..725144) /locus_tag="YPR096C" /experiment="EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:32639961]" /note="hypothetical protein; may interact with ribosomes, based on co-purification experiments" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11511.1" /db_xref="SGD:S000006300" /translation="MRGETGVSIKNPRPSRPFSCFWRKGDVENIRKSDIGNEKKIDAK FNRLQYNLYYKPLSHHKAGLLYKELFFRSCFSYTTCSLDFQGKRHQVERKAVDIVL" gene 725394..728615 /gene="LEC1" /locus_tag="YPR097W" mRNA 725394..728615 /gene="LEC1" /locus_tag="YPR097W" /product="Lec1p" CDS 725394..728615 /gene="LEC1" /locus_tag="YPR097W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:11557775]" /note="Phosphoinositide-binding regulator of ergosterol distribution; contains PX (Phox homology) domain; associated with ER-lipid droplet contact site; may facilitate ergosterol transport between plasma membrane and lipid droplets" /codon_start=1 /product="Lec1p" /protein_id="DAA11512.2" /db_xref="SGD:S000006301" /translation="MITQDTPALNPTEEHYLKRELLRCQLDYEIGKLNDQFALRKFGY PFSPNDPTAPQPISNNDSSPVLGGKGHFSVNYPMLSYVLQEFISTFPLLSTNLLVDEK FWQSKVQVFFEHFMSLGFSESYDREEASKRKKVSKKLSKVILLLFNSGVGSFQEQAYY NEDKFVLQSGQARKRSNIEKFAMPTRENLENLLTNESVFINGWDVNIISVFNKNSRKC TESVDNDKSSKSTPTSSPKSHAIKSFASTSKWMKNAFNNTINSTINSMPESSASLFSK LSLGVPSTKSKQSRKHHYFLIKIKKQDDDDQDNSNEENSNLDHHAGYFYVTRTYSDFK KLSHDLKSEFPGKKCPRLPHRNKKVTSMITKTEVLHNGQTKSAAREKIVNTFDTDLQS ASESDNSSFLQTTNELSATETVLTEKETETLRKNILNEIKEEDNIDEDEYEEEGEGEE SDFDEYKDASDSKINTLVGEKMRTSLRQYLRTLCKDAEVSQSSSIRRFFLSGPNLDIK DINPKIADDIRNRALIDVSNLENQIRFQQMALEKSLKLQDSMKDFKTSLLKDEKYLMS LLVEIKDNTKVEDLSPLLQDFVEWCKIYISSMIYQMFLGNDNSYELYTQIRRLHKLMP YTVMGQIMKFTNPIAIMRGMIELFMAQPFGGHSLLQTMFSTILTDDLKTQKVAIKELE RKIAEMDPGASVVTKCLKDFVFNNDTKDEHDTKLFTMDAVNAESESMNMPVPLIVLMK SAAANLIPDEVVAGLIESYSSWKLQKEDTDALNVTSEDQSGIYFTHVKDLWQLYIKEH DKQLMRQLWQDPELTQMLKAIVTMIYEPMVKIFKVARMDVALKNFEKFMSDLIRLVDD VINGQLGVSTQFDVVEEIHNLVTKHQDAFFEFIHDVYLNDSEGIFEGFITWITTIVKF LQKSKFGGPSERIDFNKLICRDDIDIDVKLLKVQVNNVLNKKIGARKIYKKLLDLKVK QGTKQNNKHAAGILQKNWSDINSLVMPSSSGSFGLGDGDLVDLDLDTGDYDFLHKENE VELEKQYKDLLNLVVDESEIDKLRSQVFAQELKNYLEAQIAKK" gene complement(728947..729528) /gene="TMH18" /locus_tag="YPR098C" mRNA complement(join(728947..729385,729482..729528)) /gene="TMH18" /locus_tag="YPR098C" /product="Tmh18p" CDS complement(join(728947..729385,729482..729528)) /gene="TMH18" /locus_tag="YPR098C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /note="Mitochondrial hypothetical protein; localized to the mitochondrial outer membrane" /codon_start=1 /product="Tmh18p" /protein_id="DAA11513.1" /db_xref="SGD:S000006302" /translation="MCLVKTTAHLLFYSFVFGGTTFYSYVASPIAFKVLEKDQFSALQ NKIFPYFFQMQAASPVILALTAPIALTTGPLSSLVVASVSGLTNLFWLLPWTHKVKEQ RKNIAKKYTGSELEAKDAILRKEFGKSHGLSLLFNLSNVCGMLAYGVCLSGGLLRKIP K" gene complement(729757..730113) /locus_tag="YPR099C" mRNA complement(729757..730113) /locus_tag="YPR099C" /product="hypothetical protein" CDS complement(729757..730113) /locus_tag="YPR099C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:31374566]" /note="Mitochondrial hypothetical protein; null mutant has a respiratory growth defect and displays reduced peroxide-induced mitochondrial ROS; partially overlaps the verified gene MRPL51/YPR100W" /codon_start=1 /product="hypothetical protein" /protein_id="DAC85312.1" /db_xref="SGD:S000006303" /translation="MSPSESFNSFSLFSTLSMFKFLTQITFSRPFVYSALNKGCPDFL ITSNCIHGNSWPHLSNLFEVKNFLMPSEDPPQLQNCKVIFLHGNTNAPTPLRPMEFRA IAFTTISPYIRVCVST" gene 729791..730213 /gene="MRPL51" /locus_tag="YPR100W" /gene_synonym="mL43" mRNA 729791..730213 /gene="MRPL51" /locus_tag="YPR100W" /gene_synonym="mL43" /product="mitochondrial 54S ribosomal protein MRPL51" CDS 729791..730213 /gene="MRPL51" /locus_tag="YPR100W" /gene_synonym="mL43" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:31374566|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:31374566]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:31374566]" /note="Mitochondrial ribosomal protein of the large subunit; required for mitochondrial genome integrity, respiratory growth, and mitochondrial redox homeostasis, partially overlaps verified gene YPR099C" /codon_start=1 /product="mitochondrial 54S ribosomal protein mL43 MRPL51" /protein_id="DAA11514.1" /db_xref="SGD:S000006304" /translation="MVVKAIARNSIGRNGVGAFVFPCRKITLQFCNWGGSSEGMRKFL TSKRLDKWGQEFPWIQFEVMRKSGHPLLRAEYTNGREKVICVRNLNIDNVENKLKLLK DSDGDILRRRTKNDNVESLNSSVRGIWSPLHAAKRHRI" gene 730492..731019 /gene="SNT309" /locus_tag="YPR101W" /gene_synonym="NTC25" mRNA 730492..731019 /gene="SNT309" /locus_tag="YPR101W" /gene_synonym="NTC25" /product="Snt309p" CDS 730492..731019 /gene="SNT309" /locus_tag="YPR101W" /gene_synonym="NTC25" /experiment="EXISTENCE:curator inference:GO:0000384 first spliceosomal transesterification activity [PMID:9528791]" /experiment="EXISTENCE:direct assay:GO:0000974 Prp19 complex [PMID:9528791]" /experiment="EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:9528791]" /experiment="EXISTENCE:genetic interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:9528791]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:9528791]" /note="Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p" /codon_start=1 /product="Snt309p" /protein_id="DAA11515.1" /db_xref="SGD:S000006305" /translation="MDGLSFVDKGKIPDGYKNEIDQLVKKEFANIKREPVHPEIRGIL AKRKGADNSVSTLTNALYTEYLKQRNNKKRRTPDFNDDDDTLFLEEYRRKYPRIDTSR YIPNESSEVSLLGIVDSYLKHQEIVLDTLLPQTVSNQWRINNDYIRQTCTIVEEMNIQ QRKQINDLEIYRKRL" gene complement(731224..731748) /gene="RPL11A" /locus_tag="YPR102C" mRNA complement(731224..731748) /gene="RPL11A" /locus_tag="YPR102C" /product="ribosomal 60S subunit protein L11A" CDS complement(731224..731748) /gene="RPL11A" /locus_tag="YPR102C" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:2277060]" /note="Ribosomal 60S subunit protein L11A; expressed at twice the level of Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11A has a paralog, RPL11B, that arose from the whole genome duplication" /codon_start=1 /product="ribosomal 60S subunit protein L11A" /protein_id="DAA11516.1" /db_xref="SGD:S000006306" /translation="MSAKAQNPMRDLKIEKLVLNISVGESGDRLTRASKVLEQLSGQT PVQSKARYTVRTFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYQLRDRNFSATGNF GFGIDEHIDLGIKYDPSIGIFGMDFYVVMNRPGARVTRRKRCKGTVGNSHKTTKEDTV SWFKQKYDADVLDK" gene 732349..733212 /gene="PRE2" /locus_tag="YPR103W" /gene_synonym="DOA3" /gene_synonym="PRG1" /gene_synonym="SRR2" mRNA 732349..733212 /gene="PRE2" /locus_tag="YPR103W" /gene_synonym="DOA3" /gene_synonym="PRG1" /gene_synonym="SRR2" /product="proteasome core particle subunit beta 5" CDS 732349..733212 /gene="PRE2" /locus_tag="YPR103W" /gene_synonym="DOA3" /gene_synonym="PRG1" /gene_synonym="SRR2" /EC_number="3.4.25.1" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]" /experiment="EXISTENCE:direct assay:GO:0019774 proteasome core complex, beta-subunit complex [PMID:9087403]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:11545745|PMID:19029916]" /experiment="EXISTENCE:mutant phenotype:GO:0004175 endopeptidase activity [PMID:8808631|PMID:9312134]" /experiment="EXISTENCE:mutant phenotype:GO:0080129 proteasome core complex assembly [PMID:8808631]" /note="Beta 5 subunit of the 20S proteasome; responsible for the chymotryptic activity of the proteasome; localizes to peroxisomes in oleate-growing cells" /codon_start=1 /product="proteasome core particle subunit beta 5" /protein_id="DAA11517.1" /db_xref="SGD:S000006307" /translation="MQAIADSFSVPNRLVKELQYDNEQNLESDFVTGASQFQRLAPSL TVPPIASPQQFLRAHTDDSRNPDCKIKIAHGTTTLAFRFQGGIIVAVDSRATAGNWVA SQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSN LVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSN YKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVK EEEGSFNNVIG" gene complement(733623..736433) /gene="FHL1" /locus_tag="YPR104C" /gene_synonym="SPP42" mRNA complement(733623..736433) /gene="FHL1" /locus_tag="YPR104C" /gene_synonym="SPP42" /product="Fhl1p" CDS complement(733623..736433) /gene="FHL1" /locus_tag="YPR104C" /gene_synonym="SPP42" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:15620355|PMID:15692568]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:27016735]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15466158]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15466158]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363|PMID:19111667]" /experiment="EXISTENCE:genetic interaction:GO:0010688 negative regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:7785326]" /experiment="EXISTENCE:genetic interaction:GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:15616569]" /experiment="EXISTENCE:mutant phenotype:GO:0010688 negative regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:15620355]" /experiment="EXISTENCE:mutant phenotype:GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:15620355|PMID:15616569]" /experiment="EXISTENCE:physical interaction:GO:0001222 transcription corepressor binding [PMID:15620355]" /experiment="EXISTENCE:physical interaction:GO:0001223 transcription coactivator binding [PMID:15620355]" /note="Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants" /codon_start=1 /product="Fhl1p" /protein_id="DAA11518.1" /db_xref="SGD:S000006308" /translation="MDGEMAIIESSNHVGTSSPTTETQFTIDSSALKDQETKESITNS PTSEVPIETKLPKSSDIVTEEKHPQNTTTDIENEVENPVTDDNGNLKLELPDNLDNAD FSKLLEFDAKNDEALFNSNELLSHTMDPVNNIDLTHDHSREVSSKEDINIEPVNPDED EREKTQDNTAAVKTEGIRNSEDTSIQKDEPTADAIYTDVHKLSVNKDTETLPTLVDEK NNMLHMRNNSITPIMFQQHELVGQPPQNTVTENNSTDAETTQRKLSEPIDASLPLPNE QPTIFAYARLDFQSFTFYVQTLHAIIGRRSENDFSHKVDVNLGPSKSISRRHAQIFYN FGTGRFELSIIGKNGAFVDDIFVEKGNTVPLRNKTKIQIGQIPFQFILPEQERNDDSK SPENADIAESEINTRNLKKNEPKSKKKITTGAKPKKAQTKPAVKKEKKPPKIPKKVYT LEEIPVEYRTKPTVSYSAMLTTCIRKYSTAKGMSLSEIYAGIRELFPYYKYCPDGWQS SVRHNLSLNKSFRKVSKEGKGWLWGLDEEYIAERERQKKKQSEIAVAKAQAAQLKLEQ QQHKLQQVPQRGKKDIVSQRSNVNARKQNISQTLAANRAASNRKNTASDNQRTMKYLQ EQLVILTRDRKGLSKQVIAAILTQALAMTINQVTQAAKNKGITGNPLTALMDKNPQHL NLILAAAVNAATAKVTKGEVKQLVNPETTAAAALAAKAQHSKPIRQPIVQTPHVPDRP PSQLSASASSHPNNYLHDKQPGSFDPSSLSRFFQPRQNARATSSVAATSVPAAASQNV DAQPKPKPAQDNDLESESGTSSSSSSSSESGSESDSGSDDGSASGSGDNSSTSSESES ESDSGSEVDEKNNKNEKIDSESIKNNESKDDIPSKDENSSNDNREISKTDEEGHDSKR RKVSEDINEGITEVNVSLEEKL" gene complement(736984..739569) /gene="COG4" /locus_tag="YPR105C" /gene_synonym="COD1" /gene_synonym="SEC38" /gene_synonym="SGF1" mRNA complement(736984..739569) /gene="COG4" /locus_tag="YPR105C" /gene_synonym="COD1" /gene_synonym="SEC38" /gene_synonym="SGF1" /product="Golgi transport complex subunit COG4" CDS complement(736984..739569) /gene="COG4" /locus_tag="YPR105C" /gene_synonym="COD1" /gene_synonym="SEC38" /gene_synonym="SGF1" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000301 retrograde transport, vesicle recycling within Golgi [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:20065092]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:20065092]" /experiment="EXISTENCE:mutant phenotype:GO:0017119 Golgi transport complex [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:20065092]" /note="Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" /codon_start=1 /product="Golgi transport complex subunit COG4" /protein_id="DAA11519.1" /db_xref="SGD:S000006309" /translation="MEGQKSNASWESSIIEGQLSKNLARYTLLLDKLSTLSQIDKLSE VIANDYAKQSKQLNAFVQQSQSSLNKESRKLELQRTNLTTTLTQFHETVATISSSNAR AKAIHDDIETVDQERALVNKTLQFVKDVRTLKNNISLAHSALETKDYLVAATAINEIR SLPDKKLIVSEFAKKVVPSSEIPEEPAILIKNWCKELTSLFQEQFMEATRTQDIKELT LMFKMFPMIGQDVLGLDLYSKYVCDIIADESRKIMSNSMENSTKFQGFFSQVLLHLFK IVSTIINDHSKVIATCYGKKHMVHVMEKVEKEADLQASLILDIFMETRKIERTIHDIN EWEHSQKNEDVNIDSNQSDIETDGETEKSSIISIHDLALLIMEFSQILQNWSMYSRFY SVKWNEFSDLHPHVLQPPPPIADGKFALKLKQDKVFDEFQVFVLNHLQRSFRNSISLE ELPSLNDLITAVPLNDHDNISYPVTSVLDDLILLVRKNLISVVNTGQFKLLASFLNEL VKFFQNRFLVKFMQNKFKLLQSKLASNVSLKRYIPKGEEQSATSRSVSPPANKFSPLS RFTFRGAAASALTNIQSNLQAVVAEDEDSILALHHYLIYLNTLYLSKVYVHRLLSIEI LEDDSQRILRDNFPFDNDAAQLQNLIINSEKLVLEQTDKLSKWAVKYLFQNILQNRVR NLLGTVFVNSASSNSSTSNQKNVSRDYSAGSNQKNYITSIEDFEDLSQINSFNSKWNQ LIIPYKNILHNEAYAELLSVIVDYIVTTLEQRIWTLEFNELGVTKLDRELSLFIGNMC GLNYNLREKFLKLTQIVLLLGLDDDNFDLTTGDIKDDFNGTFDWVINSQERIKARNMK IDRTQ" gene 740061..741392 /gene="ISR1" /locus_tag="YPR106W" mRNA 740061..741392 /gene="ISR1" /locus_tag="YPR106W" /product="putative protein kinase ISR1" CDS 740061..741392 /gene="ISR1" /locus_tag="YPR106W" /EC_number="2.7.11.1" /experiment="EXISTENCE:genetic interaction:GO:0018105 peptidyl-serine phosphorylation [PMID:32579556]" /experiment="EXISTENCE:genetic interaction:GO:0018107 peptidyl-threonine phosphorylation [PMID:32579556]" /experiment="EXISTENCE:genetic interaction:GO:0106279 negative regulation of UDP-N-acetylglucosamine biosynthetic process [PMID:32579556]" /experiment="EXISTENCE:mutant phenotype:GO:0018105 peptidyl-serine phosphorylation [PMID:32579556]" /experiment="EXISTENCE:mutant phenotype:GO:0018107 peptidyl-threonine phosphorylation [PMID:32579556]" /experiment="EXISTENCE:mutant phenotype:GO:0106279 negative regulation of UDP-N-acetylglucosamine biosynthetic process [PMID:32579556]" /note="Predicted protein kinase; negatively regulates the hexosamine biosynthetic pathway (HBP), which converts fructose-6-phosphate into UDP-N-acetylglucosamine, a precursor of chitin biosynthesis, GPI-anchor formation and glycosylation; interacts genetically with GFA1, encoding the first enzyme in the HBP; involved in Gfa1p phosphorylation (S332, T334); contains a Pho85p-regulated SCF-CDC4 phosphodegron; unstable, cell cycle regulated protein, peaking at G1/S" /codon_start=1 /product="putative protein kinase ISR1" /protein_id="DAA11520.1" /db_xref="SGD:S000006310" /translation="MNSTPPTSPVTRVSDGSFPSISNNSKGFAYRQPQKHKSNFAYSH LVSPVEEPTAKFSEAFQTDYSSKAPVATSEAHLKNDLDVLFTTPRFYSPENLALMFRL SNTVSSLEFLDEFLMGILLAPEMDFLSNPSYSLPSNKLVGQGSYSYVYPISSSASSRC NNDSGVVLKFAKSQHKSKVILQEALTLAYLQYMSPSTNESHIIPFYGLTYITKSHFRR LRSNECVPGLILPKCEMSLYHFNTAVSHKLSLITKRKIWWRLMKQMIDALKSLKTNGI IHGDIKTANILITEMHVLNGGHCKDFDFYLADFTSAFHINQTPTDLNTTVEYCAPELI DSSSDHVPTFESDLYAVGLCLLSFISQHEPYNELQALVSHGSSPGIGSSSIQQSQWLI NALLKKDPINLNMLRNDLFQDWKSELALLSRILVDRLPLENLITILDSNYI" gene complement(741438..742064) /gene="YTH1" /locus_tag="YPR107C" mRNA complement(741438..742064) /gene="YTH1" /locus_tag="YPR107C" /product="cleavage polyadenylation factor RNA-binding subunit YTH1" CDS complement(741438..742064) /gene="YTH1" /locus_tag="YPR107C" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:9224719]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]" /experiment="EXISTENCE:direct assay:GO:0006397 mRNA processing [PMID:11344258]" /experiment="EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:10899131]" /note="Essential RNA-binding component of cleavage and polyadenylation factor; contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation; relocalizes to the cytosol in response to hypoxia" /codon_start=1 /product="cleavage polyadenylation factor RNA-binding subunit YTH1" /protein_id="DAA11521.1" /db_xref="SGD:S000006311" /translation="MSLIHPDTAKYPFKFEPFLRQEYSFSLDPDRPICEFYNSREGPK SCPRGPLCPKKHVLPIFQNKIVCRHWLRGLCKKNDQCEYLHEYNLRKMPECVFFSKNG YCTQSPDCQYLHIDPASKIPKCENYEMGFCPLGSSCPRRHIKKVFCQRYMTGFCPLGK DECDMEHPQFIIPDEGSKLRIKRDDEINTRKMDEEKERRLNAIINGEV" gene 742454..743743 /gene="RPN7" /locus_tag="YPR108W" mRNA 742454..743743 /gene="RPN7" /locus_tag="YPR108W" /product="proteasome regulatory particle lid subunit RPN7" CDS 742454..743743 /gene="RPN7" /locus_tag="YPR108W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19446323]" /experiment="EXISTENCE:direct assay:GO:0008541 proteasome regulatory particle, lid subcomplex [PMID:9741626]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:15102831]" /note="Essential non-ATPase regulatory subunit of the 26S proteasome; similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits" /codon_start=1 /product="proteasome regulatory particle lid subunit RPN7" /protein_id="DAA11522.1" /db_xref="SGD:S000006312" /translation="MVDVEEKSQEVEYVDPTVNRVPNYEVSEKAFLLTQSKVSIEQRK EAAEFVLAKIKEEEMAPYYKYLCEEYLVNNGQSDLEHDEKSDSLNEWIKFDQELYNEL CKKNESKIKELNEKIQKLEEDDEGELEQAQAWINLGEYYAQIGDKDNAEKTLGKSLSK AISTGAKIDVMLTIARLGFFYNDQLYVKEKLEAVNSMIEKGGDWERRNRYKTYYGIHC LAVRNFKEAAKLLVDSLATFTSIELTSYESIATYASVTGLFTLERTDLKSKVIDSPEL LSLISTTAALQSISSLTISLYASDYASYFPYLLETYANVLIPCKYLNRHADFFVREMR RKVYAQLLESYKTLSLKSMASAFGVSVAFLDNDLGKFIPNKQLNCVIDRVNGIVETNR PDNKNAQYHLLVKQGDGLLTKLQKYGAAVRLTGSDRV" gene 744284..744355 /locus_tag="YNCP0016W" tRNA 744284..744355 /locus_tag="YNCP0016W" /product="tRNA-Thr" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /experiment="EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]" /experiment="EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]" /note="Threonine tRNA (tRNA-Thr), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006752" gene 744689..745573 /gene="GLD1" /locus_tag="YPR109W" mRNA 744689..745573 /gene="GLD1" /locus_tag="YPR109W" /product="Gld1p" CDS 744689..745573 /gene="GLD1" /locus_tag="YPR109W" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:29355480]" /experiment="EXISTENCE:mutant phenotype:GO:0051668 localization within membrane [PMID:29355480]" /note="Component of Dsc E3 ligase complex in Golgi and endosomes; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; diploid deletion strain has high budding index" /codon_start=1 /product="Gld1p" /protein_id="DAA11524.1" /db_xref="SGD:S000006313" /translation="MDNFESTAEGNLSIGNKRVYELRKRNFQRNLVNNLSFLGYVLIS LEYIKYDRTVWTLITRAIVQSLISSPFPSDAKLRRLATLGADNNTTGVATLPGGRSIR FPGMFGTEMLYNSSSEAEQQDHDDTAIVSMKKQIRKFLFHGCLSLNMLFIILTILFPI DFFEPLSGSEPVDDGPKNTPSPFSNSDGLLLGERRGGLFLQMIGERLPKSNFSGNLGL VMFEFSILIVQFTLFSLTCVVLADLDFEEPERLEPVNSDGYDGSVIVARIPLNKTMNA ILNDGNINDNNENASNSV" gene complement(745828..746835) /gene="RPC40" /locus_tag="YPR110C" /gene_synonym="RPC5" mRNA complement(745828..746835) /gene="RPC40" /locus_tag="YPR110C" /gene_synonym="RPC5" /product="DNA-directed RNA polymerase core subunit RPC40" CDS complement(745828..746835) /gene="RPC40" /locus_tag="YPR110C" /gene_synonym="RPC5" /experiment="EXISTENCE:direct assay:GO:0001054 RNA polymerase I activity [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0001056 RNA polymerase III activity [PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /note="RNA polymerase subunit AC40; common to RNA polymerase I and III; predominant determinant targeting Ty1 integration upstream of Pol III-transcribed genes" /codon_start=1 /product="DNA-directed RNA polymerase core subunit RPC40" /protein_id="DAA11525.1" /db_xref="SGD:S000006314" /translation="MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNI SSLDAREANFDLINIDTSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIG LVPLKVDPDMLTWVDSNLPDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNA HVYARDLKFEPQGRQSTTFADCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAK FSPVSTASYRLLPQINILQPIKGESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVS REVLRYEEFADKVKLGRVRNHFIFNVESAGAMTPEEIFFKSVRILKNKAEYLKNCPIT Q" gene 747306..749000 /gene="DBF20" /locus_tag="YPR111W" mRNA 747306..749000 /gene="DBF20" /locus_tag="YPR111W" /product="serine/threonine-protein kinase DBF20" CDS 747306..749000 /gene="DBF20" /locus_tag="YPR111W" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:8131744]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:12937277]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12937277]" /experiment="EXISTENCE:genetic interaction:GO:0000281 mitotic cytokinesis [PMID:12937277]" /experiment="EXISTENCE:genetic interaction:GO:0010458 exit from mitosis [PMID:1916278]" /experiment="EXISTENCE:mutant phenotype:GO:0000917 division septum assembly [PMID:17005296]" /experiment="EXISTENCE:mutant phenotype:GO:0061013 regulation of mRNA catabolic process [PMID:22196726]" /note="Ser/Thr kinase involved in late nuclear division; one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; DBF20 has a paralog, DBF2, that arose from the whole genome duplication" /codon_start=1 /product="serine/threonine-protein kinase DBF20" /protein_id="DAA11526.1" /db_xref="SGD:S000006315" /translation="MFSRSDREVDDLAGNMSHLGFYDLNIPKPTSPQAQYRPARKSEN GRLTPGLPRSYKPCDSDDQDTFKNRISLNHSPKKLPKDFHERASQSKTQRVVNVCQLY FLDYYCDMFDYVISRRQRTKQVLRYLEQQRSVKNVSNKVLNEEWALYLQREHEVLRKR RLKPKHKDFQILTQVGQGGYGQVYLAKKKDSDEICALKILNKKLLFKLNETNHVLTER DILTTTRSDWLVKLLYAFQDPESLYLAMEFVPGGDFRTLLINTRILKSGHARFYISEM FCAVNALHELGYTHRDLKPENFLIDATGHIKLTDFGLAAGTVSNERIESMKIRLEEVK NLEFPAFTERSIEDRRKIYHNMRKTEINYANSMVGSPDYMALEVLEGKKYDFTVDYWS LGCMLFESLVGYTPFSGSSTNETYENLRYWKKTLRRPRTEDRRAAFSDRTWDLITRLI ADPINRVRSFEQVRKMSYFAEINFETLRTSSPPFIPQLDDETDAGYFDDFTNEEDMAK YADVFKRQNKLSAMVDDSAVDSKLVGFTFRHRDGKQGSSGILYNGSEHSDPFSTFY" rep_origin 749099..749345 /note="ARS1626; Autonomously Replicating Sequence" /db_xref="SGD:S000118422" gene complement(749256..751919) /gene="MRD1" /locus_tag="YPR112C" mRNA complement(749256..751919) /gene="MRD1" /locus_tag="YPR112C" /product="RNA-binding ribosome biosynthesis protein MRD1" CDS complement(749256..751919) /gene="MRD1" /locus_tag="YPR112C" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11884397]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911|PMID:23193268]" /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:23193268]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11884397]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11884397]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11884397]" /experiment="EXISTENCE:mutant phenotype:GO:0034462 small-subunit processome assembly [PMID:18586827]" /note="Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region" /codon_start=1 /product="RNA-binding ribosome biosynthesis protein MRD1" /protein_id="DAA11527.1" /db_xref="SGD:S000006316" /translation="MSRIIVKGLPVYLTDDNLREHFTKRLRQKHSHQAVNGSGPDLIT DVKILRDRNGESRRFGFIGYRNEEDAFDAVEYFNGSFINTSKIEVSMAKSFADPRVPQ PMKEKRREALKRFREKEEKLLQEENRKKKKVDENKHSNIDDEIRKNKQLQEFMETMKP SSQVTSWEKVGIDKSIEDEKLKREEEDSSVQGNSLLAHALALKEENNKDEAPNLVIEN ESDDEYSALNRNRDEDQEDAGEEEKMISISNLKDTDIGLVNDDANSDEKENEKRRNLA QDEKVSDLDWFKQRRVRIKESEAETREKSSSYATEQNESLDTKKEEQPERAVPQKTDE ELAIEKINQTGRLFLRNILYTSKEEDFRKLFSPFGELEEVHVALDTRTGQSKGFAYVL FKDSKNAVNAYVELDKQIFQGRLLHILPGEEKKSHRLDEFDLKNMPLKKQKELKRKAA ASRQTFSWNSLYMNQDAVLGSVAAKLGLEKSQLIDAENSSSAVKQALAEAHVIGDVRK YFESKGVDLTKFSQLKSTNQRDDKVILVKNFPFGTTREELGEMFLPYGKLERLLMPPA GTIAIVQFRDTTSARAAFTKLSYKRFKDGIIYLERGPKDCFTKPAEADDLINNTSAKE EENPVEVKPSSNDLMEANKDVTEGSSNAHDEDVIDGPTVSIFIKNLNFSTTNQNLTDR FKVFTGFVVAQVKTKPDPKHQGKTLSMGFGFVEFRTKEQANAVIAAMDGTVIDGHKIQ LKLSHRQASQSGNTKTKSNKKSGKIIVKNLPFEATRKDVFELFNSFGQLKSVRVPKKF DKSARGFAFVEFLLPKEAENAMDQLHGVHLLGRRLVMQYAEEDAVDAEEEIARMTKKV RKQVATNEMAALRNGGGRKKLDVDDEENEGF" gene 752257..752919 /gene="PIS1" /locus_tag="YPR113W" mRNA 752257..752919 /gene="PIS1" /locus_tag="YPR113W" /product="CDP-diacylglycerol--inositol 3-phosphatidyltransferase" CDS 752257..752919 /gene="PIS1" /locus_tag="YPR113W" /EC_number="2.7.8.11" /experiment="EXISTENCE:direct assay:GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity [PMID:3005284]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:3005242]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:8543066]" /experiment="EXISTENCE:direct assay:GO:0006661 phosphatidylinositol biosynthetic process [PMID:3005284]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:6274497]" /experiment="EXISTENCE:mutant phenotype:GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity [PMID:6088233]" /experiment="EXISTENCE:mutant phenotype:GO:0006661 phosphatidylinositol biosynthetic process [PMID:6088233]" /note="Phosphatidylinositol synthase; required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins" /codon_start=1 /product="CDP-diacylglycerol--inositol 3-phosphatidyltransferase" /protein_id="DAA11528.1" /db_xref="SGD:S000006317" /translation="MSSNSTPEKVTAEHVLWYIPNKIGYVRVITAALSFFVMKNHPTA FTWLYSTSCLLDALDGTMARKYNQVSSLGAVLDMVTDRSSTAGLMCFLCVQYPQWCVF FQLMLGLDITSHYMHMYASLSAGKTSHKSVGEGESRLLHLYYTRRDVLFTICAFNELF YAGLYLQLFSNSATFGKWTTIISFPGYVFKQTANVVQLKRAALILADNDAKNANEKNK TY" gene 753301..754248 /locus_tag="YPR114W" mRNA 753301..754248 /locus_tag="YPR114W" /product="hypothetical protein" CDS 753301..754248 /locus_tag="YPR114W" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /note="Protein distantly similar to ceramide synthases, Lag1p and Lac1p; mutation confers sensitivity to inhibitors of sphingolipid biosynthesis" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11529.1" /db_xref="SGD:S000006318" /translation="MDVLLSLPQPELFKTTVIPFLANRNIIKSEAILSNLHSIFYVAI FYHIWFLFGKWILFPHLVKWKLDYDQKHNVKKDEKTTSERQAQHYKKKYTSLINQSSV HLISLLQSIVVLYYSLKFLLDPKASAEPYQTSHSRVFTENRDTQVICIFAIGYFVWDI YISTMYSTFPFVVHGIISTVVFCIGLKPYIQYYAPVFLMFELSNPSLNFRWFGIKFLP QKSKFCSLLLLLNNLTLMVVFFAARIAWGWFQIGKLCYDFYQVRNEPGFLVFDTIVIL AGNFVLDILNVIWFSTMVSVAAKVLKKGESVDKVTKNEQ" gene 754877..758128 /gene="RGC1" /locus_tag="YPR115W" mRNA 754877..758128 /gene="RGC1" /locus_tag="YPR115W" /product="Rgc1p" CDS 754877..758128 /gene="RGC1" /locus_tag="YPR115W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0090372 positive regulation of glycerol transport [PMID:19956799]" /note="Putative regulator of the Fps1p glycerol channel; multiply phosphorylated by Hog1p under osmotic stress; contains a pleckstrin homology domain; forms homodimers and heterodimerizes with paralog Ask10p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /codon_start=1 /product="Rgc1p" /protein_id="DAA11530.1" /db_xref="SGD:S000006319" /translation="MSDYFTFPKQENGGISKQPATPGSTRSSSRNLELPKNYRSFGGS SDELASMYSADSQYLMDMIPDSLTLKNEPASGNTQMNGPDGKENKDIKLDEYILPKTD PRSPYYINMPIPKKLPKSEGKARAKQKVNRADPSDLDVENIYETSGEFVREYPTDILI DRFHKWKKILKSLIAYFREAAYSQEQIARINYQMKNAVKFAFLTDLEDETNKLVDPSI SKLPTKKPQPVPLAAQKLDSKYDTDVEQPQSIQSVPSEEVASASSGFMKFGSGSIQDI QVILKKYHLSLGSQQYKISKEILAYIIPKLTDLRKDLTTKMKEIKELNGDFKTNIGEH IKITSRLLNKYIASVKLLDEASTSGDKQGEKLKPKHDPYLLKLQLDLQLKRQLLEENY LREAFLNLQSAALQLEKIVYSKIQSALQRYSALIDSEARLMIKNLCHELQQGILSRPP AVEWDNFVSHHPTCLMNLKSTDPPPQPRRLSDIVYPNMKSPLAKCIRVGYLLKKTESS KSFTKGYFVLTTNYLHEFKSSDFFLDSKSPRSKNKPVVEQSDISRVNKDGTNAGSHPS SKGTQDPKLTKRRKGLSSSNLYPISSLSLNDCSLKDSTDSTFVLQGYASYHSPEDTCT KESSTTSDLACPTKTLASNKGKHQRTPSALSMVSVPKFLKSSSVPKEQKKAKEEANIN KKSICEKRVEWTFKIFSASLEPTPEESKNFKKWVQDIKALTSFNSTQERSNFIEEKIL KSRNHNNGKSSQRSKNSTYITPVDSFVNLSEKVTPSSSVTTLNTRKRANRPRYIDIPK SANMNAGAMNSVYRSKVNTPAIDENGNLAIVGETKNSAPQNGMSYTIRTPCKSPYSPY TGEGMLYNRSADNLMASSSRKASAPGEVPQIAVSNHGDEAIIPASAYSDSSHKSSRAS SVASIHNQRVDFYPSPLMNLPGVSPSCLALDGNANGYFGIPLNCNSEARRGSDLSPFE MESPLFEENRTQNCSGSRKSSACHIPHQCGPRKEGNDSRLIYGNEKGASQSRLTLKEP LTSKGVEAPYSSLKKTYSAENVPLTSTVSNDKSLHSRKEGSTNTVPATSASSK" gene 758648..759481 /gene="RRG8" /locus_tag="YPR116W" /gene_synonym="MTA1" mRNA 758648..759481 /gene="RRG8" /locus_tag="YPR116W" /gene_synonym="MTA1" /product="Rrg8p" CDS 758648..759481 /gene="RRG8" /locus_tag="YPR116W" /gene_synonym="MTA1" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0099617 matrix side of mitochondrial inner membrane [PMID:30759361]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:19751518]" /experiment="EXISTENCE:mutant phenotype:GO:0097745 mitochondrial tRNA 5'-end processing [PMID:30759361]" /note="hypothetical protein; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport; localizes to the matrix side of the inner mitochondrial membrane" /codon_start=1 /product="Rrg8p" /protein_id="DAA11531.1" /db_xref="SGD:S000006320" /translation="MGLPKSAYKKLLIDCPTRVINKNCAQRVKDVSPLITNFEKWSDK RKKLYFKDEEEMVGQFHLENFNLKNNLYGRLLASPMRAEKISKLKSCRELLIPLKVVP STGKDQHADKDKLKLVPTLDYSKSYKSSYVLNSASIVQDNLAAATSWFPISVLQTSTP KSLEVDSSTFITEYNANLHAFIKARLSVIPNVGPSSINRVLLICDKRKTPPIEIQVVS HGKGLPITQSVFNLGYLHEPTLEAIVSKDAVTNGIYLDADNDKDLIKHLYSTLLFHSV N" gene 760025..767494 /gene="HOB2" /locus_tag="YPR117W" mRNA 760025..767494 /gene="HOB2" /locus_tag="YPR117W" /product="Hob2p" CDS 760025..767494 /gene="HOB2" /locus_tag="YPR117W" /note="Modulator of cellular lipid distribution; localizes to ER-PM and ER-mitochondria contact sites; shares homology with lipid transfer proteins Vps13p and Atg2p; homolog of D. melanogaster Hobbit protein" /codon_start=1 /product="Hob2p" /protein_id="DAA11532.1" /db_xref="SGD:S000006321" /translation="MSMLPWSQIRDVSKLLLGFMLFIISIQKIASILMSWILMLRHST IRKISFGYFFGTSIRRAFILTDFAQIYIGKITLRIGWKPGIVFHNVDLKLFGKDSHIT AHSTKDSRTYFNPRDQTFTFVINRRVLSILKLVFSFSTFFHTLALTVPNGKQYKLNIG SITISHPHDDTIKLEAFLHDFTHPETKDTLNHTGFFMVCKIGKEDDTGSNCTKVILKN WKSSLKISDVCWHLPEKKGKNLHSEPVEPFSAGDDAEMLTSYRKMLKPFHYPLKTLNI LDLKVENVKLIYKKKFTIRISSAQLYLESISILNNVSALELLPLNKPTWGDFELSLSA NAVVVDIDGNTAVRIPFGNVILTSDILLFLLDNVPLRRTKVSSILNIINPSVFLTIHQ VLEVLHLVDKFDSPETSSCTNTNDRSLNILDLDIDRLPSFNFELLMSNFISRLHISDE ENVTFKVFSTHALFSRNNLSMTPKKGQVMQIRPDWPFAKTALVSDQLSNYIKIVGTSL SYLRIPTEQDANPVSIPVCGFERLDTFLDEFSNSKLIVQSTLRHSYVSLENIEVLHTL SRAFDKIYLLISSRTKRNAAHKANGGKLGDLNEAKKTFNWSLKLRMKDISCSLLVAGF LPKNLDPVEAENFNLSDVTRGAKVVFTESILLADSQEKNFTIIDASVYRFMDGTTYKP SPEVIIQFTNLLLSFNDSDEIHFSLPKIKFKMDVNIIWLWFYIRSIWIKFRPNSKLSR NSVSSVKSVNVLDRLRVDIGKMIIELTLPHNTEVLLIFERIGLSSSTKNLTIASLSAY VVSVYVKHIKVYVSLLNINDFELDTEELICKKSAVINTSLIHFHAEYHFRFYMITDNI VTLYKSFKQIKLAFSNLNEFKRLYPQQQFPKKVPNLHICCQDFLIDIEEDPFEQELGL ILKVGVLEQRERLKKLEEFKEKLSTYEDMNVRLRSLYDTSRGQSFFPEFYANDQEYEQ KAYLRLLENFSTSWIARYRKAKLSFYGMPYRVISREELGTKYHLFTRQKTSTVANLVV KDLDFKLGSPSFPLDNYMDFVYQYGKKVPKSTEYTLLIILGLKIKSALWELRLRDYPI PAISFPDTFTTGDVVFAEKMPAPCALHTVYVPFVSSAQRSPYNDANTIYGLHIIRTIN SVKTYFNIRSMVTSSSSARITWGKSLQPGYESLMLWFDFLTKPLIDPSKKLGFWDKFR YLVHGKWIYEFSEESEIHLNIKGSHDPYKITDDGAGLAFCWSGGTTIYVHNSTDPKEF LKIESQRFQLAVPDFAKVSKFDKVFMKLDGRVIWTLGLLFEQGDISKAGDEERFLPNR PHYEIQLMNPDGVADLDHHDTYKGFRTSFIHMSFGVYSSEHGSINSLYLAPYALTHFF KWWNLFHTYTSGPIRQGRLFTDVLQNKTKFGRSLFTIAYQLHLKRLMVTHIYRHITTQ YDLEKDRKITFTGLKGRFDSLKIDLHQKRVKLTHTNQKLNKSKPVWKFKMSRGEIDCA EADIRILSTLFDQEAVKEILTSGLDGILEDEPSRPITPQDVEYLRESDWYDYEDYIDL NQVPLGSSLPLKLEAIPLLYSPRISYFRKINDDGYVLAYPFGTEESHNCLIGKNHPEL TQEKLATERKREIEEQLKLLHITLSELQSNKGGGSVSGNSERYARELKAEVAELNHRL HTVNTILSDLKISETIPGGNTDGDSSSSLSDTDVNLENAPPIQNRISLLRTNTVESFV SMRKASTMQVESTYDNRFMVHNIELKIDNKIRHHLLEYASSAFERKSMRFAVTYKSVT ILKELLGNVLTGVRTSVEDYGSILEDDLASNSEFIEHFEKLIREVPSDDFDYVDNYLF RLISPQVQIKSDVERNAAVILAARDIEMGIIDIVQVYGKSGKRIPVDVDTIVETRYSA VSKDIQLFTLFKKDLEGPEGRFFHKNGYGSDKESDIWPPWIPLEMCFDGSLLDKHVFL KRRSMFLTYVAPNPLFFSANDTSAFSYDSRFRIAFPGLVLTSDCQQYCAVYAIAEDLL SFGSSLDEKVEKLSRILFTDEVRNNLENLDVSVVTALQERIKELYYTRAYLKLHEPRL FMKSGQELTFDIQTSTLKLTLLMTAIKKTYDRMGSGNRVIQKRLRWQVGTDELIWELY DESKTPFVTIGLGPSTFIRSETSDGTNSNKVSISSLQCFNQQENPVYTELLAPFYENS SYNKNAPMVEIFWILGPSVGGISDLQDLIVSLQPLIFKMDHKTSEKLMNYLFPKIEQT SIEPNSPELVPRSSTSSFFSSSPVLRHSLSNGSLSVYDAKDVDSWDLRSIQSKEGIKK HKGDHRKLSASLFVQPDYNINEMVKRSGTFFNVKSIIIRKTLMSVCYKGSHSLLTDVN NLIVRVPVLKYHNKLWSREEFFTALKRDVVRIVLQHLGNIIGNKFLPHKKENKKKTSM EIHRLLSPDSQNRDNSHILEVEGHNSFYSSTHSSDIRSINSDETYNENDGNGVKPFYP VTSEFSKNK" gene 767752..768987 /gene="MRI1" /locus_tag="YPR118W" mRNA 767752..768987 /gene="MRI1" /locus_tag="YPR118W" /product="S-methyl-5-thioribose-1-phosphate isomerase MRI1" CDS 767752..768987 /gene="MRI1" /locus_tag="YPR118W" /EC_number="5.3.1.23" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0046523 S-methyl-5-thioribose-1-phosphate isomerase activity [PMID:15215245]" /experiment="EXISTENCE:mutant phenotype:GO:0019509 L-methionine salvage from methylthioadenosine [PMID:15215245|PMID:18625006]" /note="5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway" /codon_start=1 /product="S-methyl-5-thioribose-1-phosphate isomerase MRI1" /protein_id="DAA11533.1" /db_xref="SGD:S000006322" /translation="MSLEAIVFDRSEPENVSVKVLDQLLLPYTTKYVPIHTIDDGYSV IKSMQVRGAPAIAIVGSLSVLTEVQLIKHNPTSDVATLYSLVNWESTKTVLNKRLDFL LSSRPTAVNLSNSLVEIKNILKSSSDLKAFDGSLYNYVCELIDEDLANNMKMGDNGAK YLIDVLQKDGFKDEFAVLTICNTGSLATSGYGTALGVIRSLWKDSLAKTDKADSGLDN EKCPRMGHVFPLETRPYNQGSRLTAYELVYDKIPSTLITDSSIAYRIRTSPIPIKAAF VGADRIVRNGDTANKIGTLQLAVICKQFGIKFFVVAPKTTIDNVTETGDDIIVEERNP EEFKVVTGTVINPENGSLILNESGEPITGKVGIAPLEINVWNPAFDITPHELIDGIIT EEGVFTKNSSGEFQLESLF" gene complement(769207..769302) /locus_tag="YNCP0017C" tRNA complement(join(769207..769242,769266..769302)) /locus_tag="YNCP0017C" /product="tRNA-Lys" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Lysine tRNA (tRNA-Lys), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p" /db_xref="SGD:S000006635" repeat_region 769319..769659 /note="Ty3 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007216" gene 771653..773128 /gene="CLB2" /locus_tag="YPR119W" mRNA 771653..773128 /gene="CLB2" /locus_tag="YPR119W" /product="B-type cyclin CLB2" CDS 771653..773128 /gene="CLB2" /locus_tag="YPR119W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12972503|PMID:11171327]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12972503]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:12972503]" /experiment="EXISTENCE:direct assay:GO:0005819 spindle [PMID:12972503]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12972503]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:1731251]" /experiment="EXISTENCE:genetic interaction:GO:0010696 positive regulation of mitotic spindle pole body separation [PMID:1387566]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:8455600]" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:11171327]" /experiment="EXISTENCE:mutant phenotype:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:1731251|PMID:1849457]" /experiment="EXISTENCE:mutant phenotype:GO:0032888 regulation of mitotic spindle elongation [PMID:23468650]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:22918234]" /note="B-type cyclin involved in cell cycle progression; also involved in response to DNA damage; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB2 has a paralog, CLB1, that arose from the whole genome duplication" /codon_start=1 /product="B-type cyclin CLB2" /protein_id="DAA11534.1" /db_xref="SGD:S000006323" /translation="MSNPIENTENSQNTSSSRFLRNVQRLALNNVTNTTFQKSNANNP ALTNFKSTLNSVKKEGSRIPQFTRESVSRSTAAQEEKRTLKENGIQLPKNNLLDDKEN QDPSSQQFGALTSIKEGRAELPANISLQESSSAKEIIQHDPLKGVGSSTEVVHNSVEN EKLHPARSQLQVRNTESETDSGKKRPISTIVEQELPKKFKVCDENGKEEYEWEDLDAE DVNDPFMVSEYVNDIFEYLHQLEVITLPKKEDLYQHRNIHQNRDILVNWLVKIHNKFG LLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFASETDG ACTEDEIKEGEKFILKTLKFNLNYPNPMNFLRRISKADDYDIQSRTLAKFLLEISLVD FRFIGILPSLCAAAAMFMSRKMLGKGKWDGNLIHYSGGYTKEELAPVCHMIMDYLVSP IVHDEFHRKYQSRRFMKASIISVQWALKVRKNGYDIMTLHE" gene complement(773875..775182) /gene="CLB5" /locus_tag="YPR120C" mRNA complement(773875..775182) /gene="CLB5" /locus_tag="YPR120C" /product="B-type cyclin CLB5" CDS complement(773875..775182) /gene="CLB5" /locus_tag="YPR120C" /experiment="EXISTENCE:direct assay:GO:0001932 regulation of protein phosphorylation [PMID:7954792]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10848575]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:7954792]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:8253070]" /experiment="EXISTENCE:genetic interaction:GO:0006279 premeiotic DNA replication [PMID:9732268]" /experiment="EXISTENCE:genetic interaction:GO:0010696 positive regulation of mitotic spindle pole body separation [PMID:11438663|PMID:16688214]" /experiment="EXISTENCE:genetic interaction:GO:0045740 positive regulation of DNA replication [PMID:8319908]" /experiment="EXISTENCE:genetic interaction:GO:1901673 regulation of mitotic spindle assembly [PMID:8319908]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:8319908|PMID:8253070]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:8319908]" /experiment="EXISTENCE:mutant phenotype:GO:0006279 premeiotic DNA replication [PMID:9732268]" /experiment="EXISTENCE:mutant phenotype:GO:0045740 positive regulation of DNA replication [PMID:9734354|PMID:8319908]" /note="B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase; CLB5 has a paralog, CLB6, that arose from the whole genome duplication" /codon_start=1 /product="B-type cyclin CLB5" /protein_id="DAA11535.1" /db_xref="SGD:S000006324" /translation="MGENHDHEQSIKRNSMIYNENERQLCNSNLKILQNKRALSKNDS SSKQQVQDSKPRRALTDVPVNNNPLSQNKRIVAGSKAAKVRREENIRPIVSAVQKRQI YNDRTAAEQEEEEEEEGEDDDAASIVNKKRRIDAEGVSEIVGWQDLDYVEKDDTAMVA EYSAEIFAFLYRRELETLPSHNYLLDKTSKYYLRPSMRTILVDWLVEVHEKFQCYPET LFLSINLMDRFLAKNKVTMNKLQLLAVTSLFIAAKFEEVNLPKLAEYAYITDGAASKN DIKNAEMFMLTSLEFNIGWPNPLNFLRRISKADDYDPVNRNIGKFILEYAYCCHQFIH LPPSTVSAMAMYIARRMTNRNKNELWNGTLQHYSGGIDPIHDEAFQSLCIDLVKDIAS SKTHLDSLILKYKKPRYGSVYFQTFKWCTSEMHSNFQNLFNLK" gene complement(775765..775836) /locus_tag="YNCP0018C" tRNA complement(775765..775836) /locus_tag="YNCP0018C" /product="tRNA-Cys" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Cysteine tRNA (tRNA-Cys), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006529" repeat_region 776093..776413 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007211" repeat_region complement(776667..776796) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007201" rep_origin 776926..777156 /note="ARS1635; Autonomously Replicating Sequence" /db_xref="SGD:S000119041" repeat_region 777832..778154 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007212" gene 778583..780301 /gene="THI22" /locus_tag="YPR121W" mRNA 778583..780301 /gene="THI22" /locus_tag="YPR121W" /product="putative phosphomethylpyrimidine kinase" CDS 778583..780301 /gene="THI22" /locus_tag="YPR121W" /experiment="EXISTENCE:expression pattern:GO:0009228 thiamine biosynthetic process [PMID:10383756]" /note="Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively" /codon_start=1 /product="putative phosphomethylpyrimidine kinase" /protein_id="DAA11536.2" /db_xref="SGD:S000006325" /translation="MVIILLGLCTLGFPRTAFCPSIMTNSTVSINTPPPYLTLACNEK LPTVMSIAGSDSSGGAGVEADIKTITAHRCYAMTCVTTLTAQTPVKVYGAQNIPKKMV SQILDANLQDMKCNVIKTGMLTVDAIEVLHEKLLQLGENRPKLVIDPVLCAASDSSPT GKDVVSLIIEKISPFADILTPNISDCFMLLGENREVSKLQDVLEIAKDLSRITNCSNI LVKGGHIPCDDGKEKHITDVLYLGAEQKFITFKGQFVNTTRTHGAGCTLASAIASNLA RGYSLSQSVYGGIEYVQNAIAIGCDVTKKAVKVGPINHVYAVEIPLEKMLTDECFTAS DAVPKKPIEGSLDKIPGGSFFNYLINHPKVKPHWDAYVNHEFVKRVADGTLERKKFQF FIEQDYLYLIDYVRVCCVTGSKSPTLEDLEKDLVIADCARNELNEHERRLREEFGVKD PDYLQKIKRGPALRAYCRYLIDISRRGNWQEIVVALNPCLMGYVYAVDKVKDKITAAE GSIYSEWCDTCASSFCYQAVLEGERLMNHILETYPPDQLDSLVTIFARGCELETNFWT AAMEYE" gene 782045..785671 /gene="AXL1" /locus_tag="YPR122W" /gene_synonym="FUS5" /gene_synonym="STE22" mRNA 782045..785671 /gene="AXL1" /locus_tag="YPR122W" /gene_synonym="FUS5" /gene_synonym="STE22" /product="Axl1p" CDS 782045..785671 /gene="AXL1" /locus_tag="YPR122W" /gene_synonym="FUS5" /gene_synonym="STE22" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12176366]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12176366]" /experiment="EXISTENCE:genetic interaction:GO:0071432 peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion [PMID:7569998]" /experiment="EXISTENCE:mutant phenotype:GO:0000755 cytogamy [PMID:9744878]" /experiment="EXISTENCE:mutant phenotype:GO:0004222 metalloendopeptidase activity [PMID:7569998]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:7990931]" /experiment="EXISTENCE:mutant phenotype:GO:0071432 peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion [PMID:7569998]" /note="Haploid specific endoprotease of a-factor mating pheromone; performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells" /codon_start=1 /product="Axl1p" /protein_id="DAA11537.1" /db_xref="SGD:S000006326" /translation="MSLREVTNYEVSFYIPLSYSNRTHKVCKLPNGILALIISDPTDT SSSCSLTVCTGSHNDPKDIAGLAHLCEHMILSAGSKKYPDPGLFHTLIAKNNGSQNAF TTGEQTTFYFELPNTQNNGEFTFESILDVFASFFKEPLFNPLLISKEIYAIQSEHEGN ISSTTKIFYHAARILANPDHPFSRFSTGNIHSLSSIPQLKKIKLKSSLNTYFENNFFG ENITLCIRGPQSVNILTKLALSKFGDIKPKSAVKERSISIRTRSFRRSKSLKKRQDSS KNDYSDLKTFKILNTTWEKKYKNTMCFQQFPECNSIFINSNKVPIMRLLFPVSDKNTR FTKDDIKIYSHLWCELFGDESPGSLSYYLASKGWLTGCFAFTSEFAIGDIGLILELEL TNSGWENIKRITTIVLNRLLPSFYVMNIDYLITFLKEQNLIDLVSFLYQSSEDLPMEE CSKLSGILQDDLECLTPPNIFKGFKSLIEIDDPNIEKYENTKANIQWWTGQAIKFQNF LKSFMNHDNMRLLLLGNIKSGNIFDKMKNKSDICTDFFYEFEYYTANVHLASDNKFHS NSSYEFNFPTGNLFLPDCVSDPLKLQQLFLECSLKSKFATLRPQIYSEPTRTKPQLVS ENQNYEMWILKEDPNFASDNKSVVSFEVLGLGIKPSPEATIHLEVLAQALFIITSSFL YPALRIGYTYEIASSSKGNVTLRFTISGFPEGVFTIVKTFVDTLKLIATDPTFLSKDT LRKARILVRNKYKNASSDNCVKLASVGLLIVLEKYIWTLEDRINALELTELESFEKFC FLFWRNPKHLVLFMQGSLEYADAINRYLNNNFTQHLKISNEGSKPTIRLYPPPSTKDL DQGTNAFISYNGHQDDPNNSIVYFIQTAQRDDIKNLTLTFLTEYLFSLTLVPDLRNKK QIGYIVLGGLRVLTDTVGIHITVMSGSSGHNLETRINEYLSYLQLQVLNRFTEFDFRR ILLEPFLNLLKQNSTKQFEGSAGPVDLLNEIVANVQNGDNYTLNNKQMRQHRKVRNKI AEGRLNFQEDHEMIDISFLQKLTLKKYLAFFESKISIYSAQRSKLSIMITSPMAEKEI ASRKMFLQLEAFLKINGFAIKNEDLKKIVEHSKGNPILLVKNLFTYFRRRNEVFKLGT VVLQEILKIIGMNLKQRYGSILGFSSQDGEGQEIEKFWNNDTSPIVPLQELPEPNFFR KAAF" gene 786208..787428 /gene="CTR1" /locus_tag="YPR124W" mRNA 786208..787428 /gene="CTR1" /locus_tag="YPR124W" /product="high-affinity Cu transporter CTR1" CDS 786208..787428 /gene="CTR1" /locus_tag="YPR124W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922|PMID:7929270]" /experiment="EXISTENCE:mutant phenotype:GO:0005375 copper ion transmembrane transporter activity [PMID:7929270]" /experiment="EXISTENCE:mutant phenotype:GO:0015677 copper ion import [PMID:7929270]" /note="High-affinity copper transporter of plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress; human homolog SLC31A1 can complement a yeast ctr1 ctr3 double deletion" /codon_start=1 /product="high-affinity Cu transporter CTR1" /protein_id="DAA11538.1" /db_xref="SGD:S000006328" /translation="MEGMNMGSSMNMDAMSSASKTVASSMASMSMDAMSSASKTILSS MSSMSMEAMSSASKTLASTMSSMASMSMGSSSMSGMSMSMSSTPTSSASAQTTSDSSM SGMSGMSSSDNSSSSGMDMDMSMGMNYYLTPTYKNYPVLFHHLHANNSGKAFGIFLLF VVAAFVYKLLLFVSWCLEVHWFKKWDKQNKYSTLPSANSKDEGKHYDTENNFEIQGLP KLPNLLSDIFVPSLMDLFHDIIRAFLVFTSTMIIYMLMLATMSFVLTYVFAVITGLAL SEVFFNRCKIAMLKRWDIQREIQKAKSCPGFGNCQCGRHPEPSPDPIAVADTTSGSDQ STRLEKNNESKVAISENNQKKTPTQEEGCNCATDSGKNQANIERDILENSKLQEQSGN MDQNLLPAEKFTHN" gene 787961..789325 /gene="YLH47" /locus_tag="YPR125W" /gene_synonym="MRS7" mRNA 787961..789325 /gene="YLH47" /locus_tag="YPR125W" /gene_synonym="MRS7" /product="Ylh47p" CDS 787961..789325 /gene="YLH47" /locus_tag="YPR125W" /gene_synonym="MRS7" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14562095|PMID:16823961|PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:16476776]" /experiment="EXISTENCE:genetic interaction:GO:0006813 potassium ion transport [PMID:20197279]" /experiment="EXISTENCE:genetic interaction:GO:1902600 proton transmembrane transport [PMID:20197279]" /experiment="EXISTENCE:mutant phenotype:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:16476776]" /note="Mitochondrial inner membrane protein; exposed to the mitochondrial matrix; associates with mitochondrial ribosomes; NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome" /codon_start=1 /product="Ylh47p" /protein_id="DAA11539.1" /db_xref="SGD:S000006329" /translation="MLKYRSLPIKRAIHHPAPGITPISPRIMVSRLRVIPSFNLKFNR WNSSVPESSKKELKTTDGNQESASKVSPVKEKEKVPFKVKMQKALRHYWDGSKLLGLE IKISSKLLMKSAAGYPLTRRENLQLKRTTQDIVRLVPFAAFLIIPFAELLLPFALKLF PNLLPSTYESSKKRENKLENLRNTRKLMSEIIKNNKSHFKPNNISEEQKALFNRFYTH VRATGVPESRQQLIEVARLFTDDTVLDNVTRPYLIALAKYMNLQPFGTDVMLRYRIRY KMLELKKDDLSIYYEDAEQLSLSELKTACASRGIRSVDVEPSVLYSNLRLWLNMRLKD KIPSTLLIMATAYNYGNVQSKESLYDALCDVLIGIPDELYHEVKVNVVKEDEASAKQK LKQLREQEEIMKEEEQQEENAIVSVKDELSLDDQDKNIDAAAPDVKPHDTKPIGEAAA IKEK" gene 790083..791120 /locus_tag="YPR127W" mRNA 790083..791120 /locus_tag="YPR127W" /product="pyridoxine 4-dehydrogenase" CDS 790083..791120 /locus_tag="YPR127W" /EC_number="1.1.1.65" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus" /codon_start=1 /product="pyridoxine 4-dehydrogenase" /protein_id="DAA11540.1" /db_xref="SGD:S000006331" /translation="MSVADLKNNIHKLDTGYGLMSLTWRAEPIPQSQAFEAMHRVVEL SRERGHKAFFNVGEFYGPDFINLSYVHDFFAKYPDLRKDVVISCKGGADNATLTPRGS HDDVVQSVKNSVSAIGGYIDIFEVARIDTSLCTKGEVYPYESFEALAEMISEGVIGGI SLSEVNEEQIRAIHKDWGKFLTCVEVELSLFSNDILHNGIAKTCAELGLSIICYSPLG RGLLTGQLKSNADIPEGDFRKSLKRFSDESLKKNLTLVRFLQEEIVDKRPQNNSITLA QLALGWVKHWNKVPEYSGAKFIPIPSGSSISKVNENFDEQKTKLTDQEFNAINKYLTT FHTVGDRYEMA" gene complement(791218..792204) /gene="ANT1" /locus_tag="YPR128C" mRNA complement(791218..792204) /gene="ANT1" /locus_tag="YPR128C" /product="Ant1p" CDS complement(791218..792204) /gene="ANT1" /locus_tag="YPR128C" /experiment="EXISTENCE:direct assay:GO:0000295 adenine nucleotide transmembrane transporter activity [PMID:11566870]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:11566870]" /experiment="EXISTENCE:direct assay:GO:0015867 ATP transport [PMID:11566870]" /experiment="EXISTENCE:mutant phenotype:GO:0000295 adenine nucleotide transmembrane transporter activity [PMID:11390660]" /experiment="EXISTENCE:mutant phenotype:GO:0006635 fatty acid beta-oxidation [PMID:11566870|PMID:11390660]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:11390660]" /note="Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation" /codon_start=1 /product="Ant1p" /protein_id="DAA11541.1" /db_xref="SGD:S000006332" /translation="MLTLESALTGAVASAMANIAVYPLDLSKTIIQSQVSPSSSEDSN EGKVLPNRRYKNVVDCMINIFKEKGILGLYQGMTVTTVATFVQNFVYFFWYTFIRKSY MKHKLLGLQSLKNRDGPITPSTIEELVLGVAAASISQLFTSPMAVVATRQQTVHSAES AKFTNVIKDIYRENNGDITAFWKGLRTGLALTINPSITYASFQRLKEVFFHDHSNDAG SLSAVQNFILGVLSKMISTLVTQPLIVAKAMLQSAGSKFTTFQEALLYLYKNEGLKSL WKGVLPQLTKGVIVQGLLFAFRGELTKSLKRLIFLYSSFFLKHNGQRKLAST" gene 792687..793736 /gene="SCD6" /locus_tag="YPR129W" /gene_synonym="LSM13" mRNA 792687..793736 /gene="SCD6" /locus_tag="YPR129W" /gene_synonym="LSM13" /product="Scd6p" CDS 792687..793736 /gene="SCD6" /locus_tag="YPR129W" /gene_synonym="LSM13" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:22284680]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:22284680]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405|PMID:22284680]" /experiment="EXISTENCE:direct assay:GO:0031370 eukaryotic initiation factor 4G binding [PMID:22284680]" /experiment="EXISTENCE:direct assay:GO:0045947 negative regulation of translational initiation [PMID:20832728]" /experiment="EXISTENCE:mutant phenotype:GO:0033962 P-body assembly [PMID:22284680]" /experiment="EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:22284680]" /experiment="EXISTENCE:mutant phenotype:GO:0045947 negative regulation of translational initiation [PMID:20832728]" /note="Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress" /codon_start=1 /product="Scd6p" /protein_id="DAA11542.1" /db_xref="SGD:S000006333" /translation="MSQYIGKTISLISVTDNRYVGLLEDIDSEKGTVTLKEVRCFGTE GRKNWGPEEIYPNPTVYNSVKFNGSEVKDLSILDANINDIQPVVPQMMPPASQFPPQQ AQSPPQAQAQAHVQTNPQVPKPESNVPAAVAGYGVYTPTSTETATASMNDKSTPQDTN VNSQSRERGKNGENEPKYQRNKNRSSNRPPQSNRNFKVDIPNEDFDFQSNNAKFTKGD STDVEKEKELESAVHKQDESDEQFYNKKSSFFDTISTSTETNTNMRWQEEKMLNVDTF GQASARPRFHSRGLGRGRGNYRGNRGNRGRGGQRGNYQNRNNYQNDSGAYQNQNDSYS RPANQFSQPPSNVEF" gene complement(793911..794498) /gene="NAT3" /locus_tag="YPR131C" /gene_synonym="NAA20" /gene_synonym="RAD56" mRNA complement(793911..794498) /gene="NAT3" /locus_tag="YPR131C" /gene_synonym="NAA20" /gene_synonym="RAD56" /product="peptide alpha-N-acetyltransferase complex B subunit NAT3" CDS complement(793911..794498) /gene="NAT3" /locus_tag="YPR131C" /gene_synonym="NAA20" /gene_synonym="RAD56" /EC_number="2.3.1.254" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031416 NatB complex [PMID:12783868]" /experiment="EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:12808144]" /experiment="EXISTENCE:genetic interaction:GO:0032956 regulation of actin cytoskeleton organization [PMID:12808144]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:12808144]" /experiment="EXISTENCE:mutant phenotype:GO:0004596 peptide alpha-N-acetyltransferase activity [PMID:10545125]" /experiment="EXISTENCE:mutant phenotype:GO:0017196 N-terminal peptidyl-methionine acetylation [PMID:10545125]" /experiment="EXISTENCE:mutant phenotype:GO:0032956 regulation of actin cytoskeleton organization [PMID:12808144]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:23363603]" /note="Catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met" /codon_start=1 /product="peptide alpha-N-acetyltransferase complex B subunit NAT3" /protein_id="DAA11543.1" /db_xref="SGD:S000006335" /translation="MTTIQPFEPVDLFKTNNVNLDILTENFPLEFYFEYMIIWPDLFF KSSEMTVDPTFKHNISGYMMAKTEGKTTEWHTHITAVTVAPRFRRISLASKLCNTLET MTDVMPHEVNFIDLFVKCNNQLAIKLYEKLGYSVYRRVVGYYNSAEDGYPDTLKKVDD NKDAFDMRKAMARDRNRSVRPDGRSHKCYPHDVRF" gene 794965..795767 /gene="RPS23B" /locus_tag="YPR132W" mRNA join(794965..795029,795395..795767) /gene="RPS23B" /locus_tag="YPR132W" /product="ribosomal 40S subunit protein S23B" CDS join(794965..795029,795395..795767) /gene="RPS23B" /locus_tag="YPR132W" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /experiment="EXISTENCE:genetic interaction:GO:0006450 regulation of translational fidelity [PMID:8415737|PMID:8950190]" /experiment="EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:8415737|PMID:8950190]" /note="Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal" /codon_start=1 /product="ribosomal 40S subunit protein S23B" /protein_id="DAA11544.1" /db_xref="SGD:S000006336" /translation="MGKGKPRGLNSARKLRVHRRNNRWAENNYKKRLLGTAFKSSPFG GSSHAKGIVLEKLGIESKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEV LLAGFGRKGKAKGDIPGVRFKVVKVSGVSLLALWKEKKEKPRS" gene complement(795978..797210) /gene="SPN1" /locus_tag="YPR133C" /gene_synonym="IWS1" mRNA complement(795978..797210) /gene="SPN1" /locus_tag="YPR133C" /gene_synonym="IWS1" /product="Spn1p" CDS complement(795978..797210) /gene="SPN1" /locus_tag="YPR133C" /gene_synonym="IWS1" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:12556496|PMID:18086892|PMID:12524336]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:29300974]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:12556496|PMID:12524336]" /experiment="EXISTENCE:genetic interaction:GO:0034243 regulation of transcription elongation by RNA polymerase II [PMID:18086892]" /experiment="EXISTENCE:mutant phenotype:GO:0005665 RNA polymerase II, core complex [PMID:32941642]" /experiment="EXISTENCE:mutant phenotype:GO:0006334 nucleosome assembly [PMID:29300974]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:19034519]" /experiment="EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:18086892|PMID:12556496]" /experiment="EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:12556496]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12556496]" /note="Protein involved in RNA polymerase II transcription; also required for histone modifications and splicing; constitutively recruited to the CYC1 promoter and required for recruitment of chromatin remodeling factors for the expression of CYC1 gene; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain is highly conserved throughout eukaryotes; mutations confer an Spt- phenotype" /codon_start=1 /product="transcription factor SPN1" /protein_id="DAA11545.1" /db_xref="SGD:S000006337" /translation="MSTADQEQPKVVEATPEDGTASSQKSTINAENENTKQNQSMEPQ ETSKGTSNDTKDPDNGEKNEEAAIDENSNVEAAERKRKHISTDFSDDDLEKEEHNDQS LQPTVENRASKDRDSSATPSSRQELEEKLDRILKKPKVRRTRRDEDDLEQYLDEKILR LKDEMNIAAQLDIDTLNKRIETGDTSLIAMQKVKLLPKVVSVLSKANLADTILDNNLL QSVRIWLEPLPDGSLPSFEIQKSLFAALNDLPVKTEHLKESGLGRVVIFYTKSKRVEA QLARLAEKLIAEWTRPIIGASDNYRDKRIMQLEFDSEKLRKKSVMDSAKNRKKKSKSG EDPTSRGSSVQTLYEQAAARRNRAAAPAQTTTDYKYAPVSNLSAVPTNARAVGVGSTL NNSEMYKRLTSRLNKKHK" gene 797557..797709 /gene="TOM5" /locus_tag="YPR133W-A" /gene_synonym="MOM8A" mRNA 797557..797709 /gene="TOM5" /locus_tag="YPR133W-A" /gene_synonym="MOM8A" /product="Tom5p" CDS 797557..797709 /gene="TOM5" /locus_tag="YPR133W-A" /gene_synonym="MOM8A" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:9217162|PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005742 mitochondrial outer membrane translocase complex [PMID:9217162]" /experiment="EXISTENCE:direct assay:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:20668160]" /experiment="EXISTENCE:mutant phenotype:GO:0006626 protein targeting to mitochondrion [PMID:9217162]" /experiment="EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:9217162]" /note="Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore" /codon_start=1 /product="Tom5p" /protein_id="DAA11546.1" /db_xref="SGD:S000006433" /translation="MFGLPQQEVSEEEKRAHQEQTEKTLKQAAYVAAFLWVSPMIWHL VKKQWK" gene 798051..798857 /gene="MSS18" /locus_tag="YPR134W" mRNA 798051..798857 /gene="MSS18" /locus_tag="YPR134W" /product="Mss18p" CDS 798051..798857 /gene="MSS18" /locus_tag="YPR134W" /experiment="EXISTENCE:direct assay:GO:0000372 Group I intron splicing [PMID:2842150]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0000372 Group I intron splicing [PMID:2842150]" /experiment="EXISTENCE:mutant phenotype:GO:0090615 mitochondrial mRNA processing [PMID:21257754]" /note="Nuclear encoded protein needed for splicing of mitochondrial intron; required for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions" /codon_start=1 /product="Mss18p" /protein_id="DAA11547.1" /db_xref="SGD:S000006338" /translation="MGLPEVNFLRKNCILVELKLFYQTVYPPKELYWNNRITAELSTF SNIKYARPTFAVNNGTFQRTRPKLDLVLASSDIRKLATVLFNLKALIMNTKGEEPTLT TMTSVQTNEEKNDNLEQKYSSLLDRWNGKVEVHDSPFLQLQRDSNLLFAERPVRYVST TEGEGVDISSEEFFRLEEEQCRRNYDVLVDEHSTPSVGMKDGQYGPNIIHFEPSLYHT YSSLPMSMKFWLNGLEDDETTMMNIDEKSAENLDILLHGFKGFSNKRVKG" gene 799234..802017 /gene="CTF4" /locus_tag="YPR135W" /gene_synonym="CHL15" /gene_synonym="POB1" mRNA 799234..802017 /gene="CTF4" /locus_tag="YPR135W" /gene_synonym="CHL15" /gene_synonym="POB1" /product="chromatin-binding protein CTF4" CDS 799234..802017 /gene="CTF4" /locus_tag="YPR135W" /gene_synonym="CHL15" /gene_synonym="POB1" /experiment="EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:11287619]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:20381454]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:16531994]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:16962805]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714|PMID:17483413]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:1448101]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:20980819]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:1341195|PMID:1448101]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:11287619]" /experiment="EXISTENCE:mutant phenotype:GO:0034085 establishment of sister chromatid cohesion [PMID:23334284]" /note="Chromatin-associated protein; required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p); recruits Mms22p to replication forks during S phase, and may link DNA synthesis to sister chromatid cohesion" /codon_start=1 /product="chromatin-binding protein CTF4" /protein_id="DAA11548.1" /db_xref="SGD:S000006339" /translation="MVSVIDKLVFDFGGKTLVSLAPDNNTLCVANKNGLTKILKTNNP EEEPETLDSSKLVSSIKCYSNSHFLMTTMQGDALRYNIDSSQEELLARFALPLRDCCV IHSGKMAVFGGDDLELILLELDDETHKKHAIKIDEQVSQISYNSQMNILAVSMINGKV QIFSLTSTIPNKVHELNDYIVANSYDDTHRDKILSNMMDDIDKDNDNDLSETADPDEN NVADPEFCAANRICTRVAWHPKGLHFALPCADDTVKIFSIKGYSLQKTLSTNLSSTKA HFIDLQFDPLRGTYIAAVDLNNKLTVWNWETSEIHYTREFKRKITNIAWKIQADSKTL DLVLGTWSGSIAIVQNLAESVVSNIPDQSVAESSTKHGLFVDSESDLENLEGNDDINK SDKLFSDITQEANAEDVFTQTHDGPSGLSEKRKYNFEDEEDFIDDDDGAGYISGKKPH NEHSYSRVHKTHSFPISLANTGKFRYMPFSPAGTPFGFTDRRYLTMNEVGYVSTVKNS EQYSITVSFFDVGRFREYHFEDLFGYDLCFLNEKGTLFGQSKTGQIQYRPHDSIHSNW TKIIPLQAGERITSVAATPVRVIVGTSLGYFRSFNQFGVPFAVEKTSPIVALTAQNYR VFSVHYSQFHGLSYSLSELGTSSKRYYKRECPLPMSLPNINSDMKKDANLDYYNFNPM GIKSLFFSSYGDPCIFGSDNTLLLLSKWRSPEESKWLPILDSNMEIWKMSGGKETTDI HVWPLALAYDTLNCILVKGKHIWPEFPLPLPSEMEIRMPVFVKSKLLEENKAILNKKN EIGADTEAEEGEEDKEIQIPVSMAAEEEYLRSKVLSELLTDTLENDGEMYGNENEVLA ALNGAYDKALLRLFASACSDQNVEKALSLAHELKQDRALTAAVKISERAELPSLVKKI NNIREARYEQQLK" gene 802359..804080 /gene="RRP9" /locus_tag="YPR137W" mRNA 802359..804080 /gene="RRP9" /locus_tag="YPR137W" /product="Rrp9p" CDS 802359..804080 /gene="RRP9" /locus_tag="YPR137W" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0031428 box C/D methylation guide snoRNP complex [PMID:11081632]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:23509373]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11105764]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11105764]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11105764]" /note="Protein involved in pre-rRNA processing; associated with U3 snRNP; component of small ribosomal subunit (SSU) processome; ortholog of the human U3-55k protein" /codon_start=1 /product="ribosomal RNA-processing protein RRP9" /protein_id="DAA11549.1" /db_xref="SGD:S000006341" /translation="MSDVTQQKKRKRSKGEVNPSKPTVDEEITDPSSNEDEQLEVSDE EDALESEEEFEGENPADKRRRLAKQYLENLKSEANDILTDNRNAEEKDLNNLKERTID EYNNFDAGDLDKDIIASRLKEDVAEQQGRVFRYFGDKLLISEAKQSFTRVGENNLTCI SCFQPVLNKYTFEESSNGDKNKGRLFAYTVSKDLQLTKYDITDFSKRPKKLKYAKGGA KYIPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPT KDRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAME RCVTVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESE APLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFND ISGETDEELRKRQLQGKKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSF ELLGELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRLGRWIANVSGARNGIYSA VIDQTGF" repeat_region 804511..804638 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007213" mobile_element complement(804645..810562) /note="YPRCTy1-2; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats" /mobile_element_type="retrotransposon:YPRCTy1-2" /db_xref="SGD:S000007208" repeat_region complement(804645..804978) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007202" gene complement(805001..810269) /locus_tag="YPR137C-B" mRNA complement(805001..810269) /locus_tag="YPR137C-B" /product="gag-pol fusion protein" CDS complement(join(805001..808963,808965..810269)) /locus_tag="YPR137C-B" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /codon_start=1 /product="gag-pol fusion protein" /protein_id="DAA11550.1" /db_xref="SGD:S000007360" /translation="MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKTEECE KASTKANSQQTTTPASSAVPENPHHASPQTAQSHSPQNGPYPQQCMMTQNQANPSGWS FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM TVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNN SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHS DDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQD NTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWV SKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNE SDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKS APSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSE YTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFS AIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGI PGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLT ASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTE DSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAP MSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKR IIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPD PFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSL EPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLL KMNTWDTDKYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDTGMQS NTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLK KSHYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDL NANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIP KLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRF DLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISD ASYGNQPYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEIHAVSEAIPLLNNLSH LVQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYY IETKKNIADVMTKPLPIKTFKLLTNKWIH" gene complement(808947..810269) /locus_tag="YPR137C-A" mRNA complement(808947..810269) /locus_tag="YPR137C-A" /product="gag protein" CDS complement(808947..810269) /locus_tag="YPR137C-A" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /codon_start=1 /product="gag protein" /protein_id="DAA11551.1" /db_xref="SGD:S000007359" /translation="MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKTEECE KASTKANSQQTTTPASSAVPENPHHASPQTAQSHSPQNGPYPQQCMMTQNQANPSGWS FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM TVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNN SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPETY" repeat_region complement(810229..810562) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007203" gene 810676..810749 /locus_tag="YNCP0019W" tRNA 810676..810749 /locus_tag="YNCP0019W" /product="tRNA-Asn" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Asparagine tRNA (tRNA-Asn), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006677" gene complement(810984..812453) /gene="MEP3" /locus_tag="YPR138C" mRNA complement(810984..812453) /gene="MEP3" /locus_tag="YPR138C" /product="ammonium permease MEP3" CDS complement(810984..812453) /gene="MEP3" /locus_tag="YPR138C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008519 ammonium channel activity [PMID:9234685]" /experiment="EXISTENCE:mutant phenotype:GO:0008519 ammonium channel activity [PMID:9234685]" /experiment="EXISTENCE:mutant phenotype:GO:0019740 nitrogen utilization [PMID:9234685]" /experiment="EXISTENCE:mutant phenotype:GO:0072488 ammonium transmembrane transport [PMID:9234685]" /note="Ammonium permease of high capacity and low affinity; belongs to Mep-Amt-Rh family of well-conserved ammonium (NH4+) transporters that includes the human Rh factors; expression is under the nitrogen catabolite repression regulation ammonia permease activity regulated by TORC1 effectors, Npr1p and Par32p; MEP3 has a paralog, MEP1, that arose from the whole genome duplication" /codon_start=1 /product="ammonium permease MEP3" /protein_id="DAA11552.1" /db_xref="SGD:S000006342" /translation="MARGDGHLWTETYDSSTVAFMILGAALVFFMVPGLGFLYSGLAR RKSALALIWVVIMATLVGILQWYFWGYSLAFSKTATNNKFIGNLDSFGFRNVYGKISD DSTYPELIYAIFQMMFMCVALSIIAGATAERGKLFPHMVFLFVFATLVYCPITYWIWA PGGWAYQWGVLDWAGGGNIEILSAVAGFVYSYFLGRRKENLLINFRPHNVSMVTLGTS ILWFGWLLFNAASSLSPNMRSVYAFMNTCLSATTGGMTWCLLDYRSEKKWSTVGLCSG IICGLVAATPSSGCITLYGSLIQGIIAGVVCNFATKIKYYLKVDDSLDLLAEHGIAGV VGLIFNALFAADWVIGMDGTTKHKGGWLTHNWKQMYIQIAYIGASAGYCAVVTAIICF VLGKIPGVHLRVTEEAEALGLDEDQIGEFAYDYVEVRRDYYQWGVDTDALHTTCNGAN SASETNPTEDSQNSSLSSATVSGQNEKSNNPKLHHAKEA" gene complement(813156..814058) /gene="LOA1" /locus_tag="YPR139C" /gene_synonym="VPS66" mRNA complement(813156..814058) /gene="LOA1" /locus_tag="YPR139C" /gene_synonym="VPS66" /product="lysophosphatidic acid acyltransferase LOA1" CDS complement(813156..814058) /gene="LOA1" /locus_tag="YPR139C" /gene_synonym="VPS66" /EC_number="2.3.1.51" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:22090344|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:22090344|PMID:21820081]" /experiment="EXISTENCE:direct assay:GO:0042171 lysophosphatidic acid acyltransferase activity [PMID:22090344]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]" /experiment="EXISTENCE:mutant phenotype:GO:0034389 lipid droplet organization [PMID:22090344]" /experiment="EXISTENCE:mutant phenotype:GO:0035356 intracellular triglyceride homeostasis [PMID:22090344]" /note="Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA" /codon_start=1 /product="lysophosphatidic acid acyltransferase LOA1" /protein_id="DAA11553.1" /db_xref="SGD:S000006343" /translation="MEKYTNWRDNGTGIAPFLPNTIRKPSKVMTACLLGILGVKTIIM LPLIMLYLLTGQNNLLGLILKFTFSWKEEITVQGIKKRDVRKSKHYPQKGKLYICNCT SPLDAFSVVLLAQGPVTLLVPSNDIVYKVSIREFINFILAGGLDIKLYGHEVAELSQL GNTVNFMFAEGTSCNGKSVLPFSITGKKLKEFIDPSITTMNPAMAKTKKFELQTIQIK TNKTAITTLPISNMEYLSRFLNKGINVKCKINEPQVLSDNLEELRVALNGGDKYKLVS RKLDVESKRNFVKEYISDQRKKRK" gene 814391..815536 /gene="TAZ1" /locus_tag="YPR140W" mRNA 814391..815536 /gene="TAZ1" /locus_tag="YPR140W" /product="lysophosphatidylcholine acyltransferase" CDS 814391..815536 /gene="TAZ1" /locus_tag="YPR140W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:14562095|PMID:24769239|PMID:15304507|P MID:26928762|PMID:15588229|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16135531|PMID:16880272]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:16880272]" /experiment="EXISTENCE:direct assay:GO:0035965 cardiolipin acyl-chain remodeling [PMID:27268057]" /experiment="EXISTENCE:direct assay:GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity [PMID:27268057]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:15304507]" /experiment="EXISTENCE:mutant phenotype:GO:0007007 inner mitochondrial membrane organization [PMID:14651618]" /experiment="EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:14651618|PMID:15588229]" /experiment="EXISTENCE:mutant phenotype:GO:0032048 cardiolipin metabolic process [PMID:14651618]" /experiment="EXISTENCE:mutant phenotype:GO:0035965 cardiolipin acyl-chain remodeling [PMID:14651618]" /experiment="EXISTENCE:mutant phenotype:GO:0042775 mitochondrial ATP synthesis coupled electron transport [PMID:15304507]" /experiment="EXISTENCE:mutant phenotype:GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity [PMID:15588229]" /experiment="EXISTENCE:mutant phenotype:GO:0097250 mitochondrial respirasome assembly [PMID:16135531]" /note="Lyso-phosphatidylcholine acyltransferase; required for normal phospholipid content of mitochondrial membranes; major determinant of the final acyl chain composition of the mitochondrial-specific phospholipid cardiolipin; mutations in human ortholog tafazzin (TAZ) cause Barth syndrome, a rare X-linked disease characterized by skeletal and cardiomyopathy and bouts of cyclic neutropenia; a specific splice variant of human TAZ can complement yeast null mutant" /codon_start=1 /product="lysophosphatidylcholine acyltransferase" /protein_id="DAA11554.1" /db_xref="SGD:S000006344" /translation="MSFRDVLERGDEFLEAYPRRSPLWRFLSYSTSLLTFGVSKLLLF TCYNVKLNGFEKLETALERSKRENRGLMTVMNHMSMVDDPLVWATLPYKLFTSLDNIR WSLGAHNICFQNKFLANFFSLGQVLSTERFGVGPFQGSIDASIRLLSPDDTLDLEWTP HSEVSSSLKKAYSPPIIRSKPSWVHVYPEGFVLQLYPPFENSMRYFKWGITRMILEAT KPPIVVPIFATGFEKIASEAVTDSMFRQILPRNFGSEINVTIGDPLNDDLIDRYRKEW THLVEKYYDPKNPNDLSDELKYGKEAQDLRSRLAAELRAHVAEIRNEVRKLPREDPRF KSPSWWKRFNTTEGKSDPDVKVIGENWAIRRMQKFLPPEGKPKGKDD" gene complement(815734..817923) /gene="KAR3" /locus_tag="YPR141C" /gene_synonym="OSR11" mRNA complement(815734..817923) /gene="KAR3" /locus_tag="YPR141C" /gene_synonym="OSR11" /product="Kar3p" CDS complement(815734..817923) /gene="KAR3" /locus_tag="YPR141C" /gene_synonym="OSR11" /EC_number="5.6.1.4" /experiment="EXISTENCE:direct assay:GO:0000922 spindle pole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:8106549|PMID:11729143|PMID:2138512]" /experiment="EXISTENCE:direct assay:GO:0005874 microtubule [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:2138512]" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:22734002]" /experiment="EXISTENCE:direct assay:GO:0008569 minus-end-directed microtubule motor activity [PMID:8041770]" /experiment="EXISTENCE:direct assay:GO:0051321 meiotic cell cycle [PMID:11729143]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:9201713]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:2138512]" /experiment="EXISTENCE:mutant phenotype:GO:0000743 nuclear migration involved in conjugation with cellular fusion [PMID:19386762|PMID:2138512|PMID:16380440]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:11729143]" /experiment="EXISTENCE:mutant phenotype:GO:0060236 regulation of mitotic spindle organization [PMID:25313961]" /note="Minus-end-directed microtubule motor; functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate" /codon_start=1 /product="Kar3p" /protein_id="DAA11555.1" /db_xref="SGD:S000006345" /translation="MESLPRTPTKGRSTQHLSTPSPKNDILAMNGHKRRNTTTPPPKH TLLKPQRTDIHRHSLASQSRISMSPNRELLKNYKGTANLIYGNQKSNSGVTSFYKENV NELNRTQAILFEKKATLDLLKDELTETKEKINAVNLKFETLREEKIKIEQQLNLKNNE LISIKEEFLSKKQFMNEGHEIHLKQLAASNKKELKQMENEYKTKIEKLKFMKIKQFEN ERASLLDKIEEVRNKITMNPSTLQEMLNDVEQKHMLEKEEWLTEYQSQWKKDIELNNK HMQEIESIKKEIENTLKPELAEKKKLLTEKRNAYEAIKVKVKEKEEETTRLRDEVALK QKTNLETLEKIKELEEYIKDTELGMKELNEILIKEETVRRTLHNELQELRGNIRVYCR IRPALKNLENSDTSLINVNEFDDNSGVQSMEVTKIQNTAQVHEFKFDKIFDQQDTNVD VFKEVGQLVQSSLDGYNVCIFAYGQTGSGKTFTMLNPGDGIIPSTISHIFNWINKLKT KGWDYKVNCEFIEIYNENIVDLLRSDNNNKEDTSIGLKHEIRHDQETKTTTITNVTSC KLESEEMVEIILKKANKLRSTASTASNEHSSRSHSIFIIHLSGSNAKTGAHSYGTLNL VDLAGSERINVSQVVGDRLRETQNINKSLSCLGDVIHALGQPDSTKRHIPFRNSKLTY LLQYSLTGDSKTLMFVNISPSSSHINETLNSLRFASKVNSTRLVSRK" gene 818323..819075 /gene="RRP15" /locus_tag="YPR143W" mRNA 818323..819075 /gene="RRP15" /locus_tag="YPR143W" /product="Rrp15p" CDS 818323..819075 /gene="RRP15" /locus_tag="YPR143W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:15769876]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15769876]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15769876]" /note="Nucleolar protein; constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs" /codon_start=1 /product="rRNA-processing protein RRP15" /protein_id="DAA11556.1" /db_xref="SGD:S000006347" /translation="MGSKHRVDTKDKKRTRKNAEFGREKRNSGNQELSNEPEKDTIME GDEAEEDEQNSSSDESSKIIDNEQSDAEEDDDEEEEDDDFPRKKKSKNSKHDDGSTGF SAAVNAILSSHLKAYDRKDPIMARNKKVLKQSESEKLEYKAKKALLAEKKKLLGKARK TDIIPIASGEDRSENIRKVLEKETALRKIAQKGAVKLFNAILATQVKTEKEVSENLSE IKNKEEKKELITEVSKEKFLDLVKAAAGSDNE" rep_origin 819160..819399 /note="ARS1627; Autonomously Replicating Sequence" /db_xref="SGD:S000118423" gene 819529..819602 /locus_tag="YNCP0020W" tRNA 819529..819602 /locus_tag="YNCP0020W" /product="tRNA-Ile" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Isoleucine tRNA (tRNA-Ile), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006611" gene complement(819765..821423) /gene="NOC4" /locus_tag="YPR144C" /gene_synonym="UTP19" mRNA complement(819765..821423) /gene="NOC4" /locus_tag="YPR144C" /gene_synonym="UTP19" /product="ribosome biosynthesis protein NOC4" CDS complement(819765..821423) /gene="NOC4" /locus_tag="YPR144C" /gene_synonym="UTP19" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12150911|PMID:12446671|PMID:15590835]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:12446671]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:12446671]" /experiment="EXISTENCE:physical interaction:GO:0030692 Noc4p-Nop14p complex [PMID:12446671]" /note="Nucleolar protein; forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits; relocalizes to the cytosol in response to hypoxia" /codon_start=1 /product="ribosome biosynthesis protein NOC4" /protein_id="DAA11557.1" /db_xref="SGD:S000006348" /translation="MVLLISEIKDIAKRLTAAGDRKQYNSIIKLINELVIPENVTQLE EDETEKNLRFLVMSLFQIFRKLFSRGDLTLPSSKKSTLEKEQFVNWCRKVYEAFKTKL LAIISDIPFETSLGLDSLDVYLQLAELESTHFASEKGAPFFPNKTFRKLIIALWSSNM GEIEDVKSSGASENLIIVEFTEKYYTKFADIQYYFQSEFNQLLEDPAYQDLLLKNVGK WLALVNHDKHCSSVDADLEIFVPNPPQAIENESKFKSNFEKNWLSLLNGQLSLQQYKS ILLILHKRIIPHFHTPTKLMDFLTDSYNLQSSNKNAGVVPILALNGLFELMKRFNLEY PNFYMKLYQIINPDLMHVKYRARFFRLMDVFLSSTHLSAHLVASFIKKLARLTLESPP SAIVTVIPFIYNLIRKHPNCMIMLHNPAFISNPFQTPDQVANLKTLKENYVDPFDVHE SDPELTHALDSSLWELASLMEHYHPNVATLAKIFAQPFKKLSYNMEDFLDWNYDSLLN AESSRKLKTLPTLEFEAFTNVFDNEDGDSEASSQGNVYLPGVAW" gene 821732..821903 /gene="SNR45" /locus_tag="YNCP0021W" ncRNA 821732..821903 /ncRNA_class="snoRNA" /gene="SNR45" /locus_tag="YNCP0021W" /product="SNR45" /experiment="EXISTENCE:direct assay:GO:0070181 small ribosomal subunit rRNA binding [PMID:28542199]" /experiment="EXISTENCE:mutant phenotype:GO:1990882 rRNA acetylation [PMID:28542199]" /experiment="EXISTENCE:physical interaction:GO:0031428 box C/D methylation guide snoRNP complex [PMID:11081632]" /note="C/D box small nucleolar RNA (snoRNA); acts as antisense guide to target RNA base acetylation by Kre33p to cytosine 1773 in 18S rRNA (responsible for ac4C 1773); establishes extended bipartite complementarity around the cytosines targeted for acetylation, similar to pseudouridylation pocket formation by the H/ACA snoRNPs; base pairing between snR45 and 18S rRNA requires the putative helicase activity of Kre33p" /db_xref="SGD:S000006505" gene 822620..824338 /gene="ASN1" /locus_tag="YPR145W" mRNA 822620..824338 /gene="ASN1" /locus_tag="YPR145W" /product="asparagine synthase (glutamine-hydrolyzing) 1" CDS 822620..824338 /gene="ASN1" /locus_tag="YPR145W" /EC_number="6.3.5.4" /experiment="EXISTENCE:direct assay:GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity [PMID:6105958]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0006529 asparagine biosynthetic process [PMID:8951815]" /note="Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication" /codon_start=1 /product="asparagine synthase (glutamine-hydrolyzing) 1" /protein_id="DAA11558.1" /db_xref="SGD:S000006349" /translation="MCGIFAAFRHEDVHRYKPKALQLSKRIRHRGPDWSGNAIKNSTI FVHERLAIVGVESGAQPITSSDGEYMLCVNGEIYNHIQLREECADYEFGTLSDCEPII PMYLKHDIDAPKYLDGMFAWTLYDAKQDRIVAARDPIGITTLYMGRSSASPKTVYFAS ELKCLTDDCDTITAFPPGHVYDSKTDKITRYFTPDWLDEKRIPSTPIDYMAIRHSLEK AVRKRLMAEVPYGVLLSGGLDSSLIASIAARETAKATNDVEPSTYDSKARHLAGIDDD GKLHTAGWTSLHSFAIGLPNAPDLQAARKVAKFIGSIHHEHTFTLQEGLDALDDVIYH LETYDVTTIRASTPMFLLSRKIKAQGVKMVLSGEGSDEIFGGYLYFAQAPSAAEFHTE SVQRVKNLHLADCLRANKSTMAWGLEARVPFLDREFLQLCMNIDPNEKMIKPKEGRIE KYILRKAFDTTGEPDAKPYLPEEILWRQKEQFSDGVGYSWIDGLKDTAEAVISDEMFA SPKAEWGSDIPTTKEAFWYRLKFDALFPQKTVADTVMRWIPKADWGCAEDPSGRYAQI HEKHIE" gene complement(824690..824926) /locus_tag="YPR145C-A" mRNA complement(824690..824926) /locus_tag="YPR145C-A" /product="hypothetical protein" CDS complement(824690..824926) /locus_tag="YPR145C-A" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11559.1" /db_xref="SGD:S000113589" /translation="MSTAFRKIKLIFKKSDSQYPQNYRAEIKSRNKNTVITRHDLLIA HEMKQRASLERSNSIRNLQSQGKRRSDSKESRKL" gene complement(825645..826559) /locus_tag="YPR147C" mRNA complement(825645..826559) /locus_tag="YPR147C" /product="bifunctional triacylglycerol lipase/ester hydrolase" CDS complement(825645..826559) /locus_tag="YPR147C" /EC_number="3.1.1.3" /experiment="EXISTENCE:direct assay:GO:0004806 triacylglycerol lipase activity [PMID:29491250]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093]" /experiment="EXISTENCE:direct assay:GO:0016788 hydrolase activity, acting on ester bonds [PMID:29491250]" /experiment="EXISTENCE:mutant phenotype:GO:0006629 lipid metabolic process [PMID:29491250]" /experiment="EXISTENCE:mutant phenotype:GO:0019433 triglyceride catabolic process [PMID:29491250]" /note="Bifunctional triacylglycerol lipase and short chain ester hydrolase; null mutant results in the accumulation of both triacylglycerol and fatty acids derived from neutral lipids and phospholipids as well as an increase in the quantity of lipid droplets; contains an alpha/beta hydrolase domain with a conserved GXSXG lipase motif; localizes to lipid droplets; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS" /codon_start=1 /product="bifunctional triacylglycerol lipase/ester hydrolase" /protein_id="DAA11560.1" /db_xref="SGD:S000006351" /translation="MTVKEYTKSKLPCSILNIKPTVTKSGEDAPLLVWIPGNPGLLYY YQEMLHHLHLKHPDWEILGISHAGMTLNAHSNTPIFSLQDQVDHQVEVINNFSCKNRK IIIMGHSVGAYIVQKVCLSNKLVGSVQKVGLVTPTVMDIHTSEMGIKMTAALRYIPPL AHVVSLFSYIFFYWILSEGFSRFIIDKFMGCGSTGYQAVLSTRIFLTHRQFVRQSLGL AAQEMEEITTNWEFQDRFINYCEENGISIWFLFSSNDHWVSGKTRSHLSDYYKDKVKQ ERLKIDVTDKIPHSFVVKHAEYAINAFF" gene complement(826833..828140) /locus_tag="YPR148C" mRNA complement(826833..828140) /locus_tag="YPR148C" /product="hypothetical protein" CDS complement(826833..828140) /locus_tag="YPR148C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11561.1" /db_xref="SGD:S000006352" /translation="MSGYFSGFSLNKITDSIATAAHKTQDTLNNALANANVNLNDPQT RLSIKSRTRFVQESLGTVSDISKLPPQYQFLEKKSDSLEKVCKRILLVSKTFEVEGYD YPPNLTESISDWWSLNKDGWFGSKKSESSTKKKGSNHDDAFLPRSFAQAISKAAVDCE CEFQNLEHNEKAELKKKKESIKTAQTTEAQGADHNEEDEEDEEDEEDDEDLSNLIKVF DSWSTCYKNIDEGKAEMDSMMVKEFNKKLETLINQDFKKVHDLRKKVEESRLKFDTMR YEVKAKEAELEAKKAEATGEAHSKDVSAKDISANTTTSFDETPSTEDEKPKSEGAEEE SKKEANEPTVDDVADRKEDLKSNKVNDEPPIEESEDNKLLEKLEDEFVSNTTAAVETM EEITDSSEILGLIKLFQNFQLVYFRQCVQEVEANLKVLNGLEI" gene 829918..830439 /gene="NCE102" /locus_tag="YPR149W" /gene_synonym="NCE2" mRNA 829918..830439 /gene="NCE102" /locus_tag="YPR149W" /gene_synonym="NCE2" /product="Nce102p" CDS 829918..830439 /gene="NCE102" /locus_tag="YPR149W" /gene_synonym="NCE2" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12469340|PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0033101 cellular bud membrane [PMID:19064668]" /experiment="EXISTENCE:direct assay:GO:0070250 mating projection membrane [PMID:19064668]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0061091 regulation of phospholipid translocation [PMID:27033517]" /experiment="EXISTENCE:mutant phenotype:GO:0001933 negative regulation of protein phosphorylation [PMID:19564405]" /experiment="EXISTENCE:mutant phenotype:GO:0007009 plasma membrane organization [PMID:19564405]" /experiment="EXISTENCE:mutant phenotype:GO:0009306 protein secretion [PMID:8655575]" /experiment="EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:27033517]" /experiment="EXISTENCE:mutant phenotype:GO:0070941 eisosome assembly [PMID:19564405|PMID:38096056]" /experiment="EXISTENCE:mutant phenotype:GO:0072659 protein localization to plasma membrane [PMID:20581291]" /experiment="EXISTENCE:mutant phenotype:GO:0097576 vacuole fusion [PMID:33114062]" /note="Protein involved in regulation of pheromone response and mating; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs); NCE102 has a paralog, FHN1, that arose from the whole genome duplication" /codon_start=1 /product="Nce102p" /protein_id="DAA11562.1" /db_xref="SGD:S000006353" /translation="MLALADNILRIINFLFLVISIGLISSLLNTQHRHSSRVNYCMFA CAYGIFTDSLYGVFANFIEPLAWPLVLFTLDFLNFVFTFTAGTVLAVGIRAHSCNNSS YVDSNKITQGSGTRCRQAQAAVAFLYFSCAIFLAKTLMSVFNMISNGAFGSGSFSKRR RTGQVGVPTISQV" gene complement(831055..831675) /gene="SUE1" /locus_tag="YPR151C" mRNA complement(831055..831675) /gene="SUE1" /locus_tag="YPR151C" /product="Sue1p" CDS complement(831055..831675) /gene="SUE1" /locus_tag="YPR151C" /experiment="EXISTENCE:direct assay:GO:0005740 mitochondrial envelope [PMID:15123691]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:15123691]" /note="Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria" /codon_start=1 /product="Sue1p" /protein_id="DAA11563.1" /db_xref="SGD:S000006355" /translation="MILLKRTKIRGVSVSFVSLQRRTHSRLVNPIRQQHQQITKQRSS KILKNAHFYDFRSLPKVPTTQYLEARELTRDILYSGYRPVMYPVKENPLFRDKKRKSL QTLLTMNEKTNAEAKTIDEKKHKNILFGERGTGGIMSGGVNGTWKYNPTVPNELLPFN WWSTSSMGMEYFPEWKNVPPYMMRKLKPFDKALQMRLTHKSKKKMK" gene complement(832061..833458) /gene="URN1" /locus_tag="YPR152C" mRNA complement(832061..833458) /gene="URN1" /locus_tag="YPR152C" /product="Urn1p" CDS complement(832061..833458) /gene="URN1" /locus_tag="YPR152C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071010 prespliceosome [PMID:19941820]" /note="hypothetical protein containing WW and FF domains; overexpression causes accumulation of cells in G1 phase" /codon_start=1 /product="Urn1p" /protein_id="DAA11564.1" /db_xref="SGD:S000006356" /translation="MRGEWQEFKTPAGKKYYYNKNTKQSRWEKPNLKKGSNLESNAKE SQTERKPTFSLELVNGWHLIIYNDGTKLYFNDDSKEFKNDISQEDDSRCRSLIESLDK EKLVLLIGVARGYTMREEDIDKILESCNEEIHLFKRNQDEVERKDEISEEAGDVKSPL QESHTGLVSGYGSSSGEEDEEEDEEEDEENEEQIVNQDISIIDDLNRIDTDDIDERNI FFELFDRYKLDKFSTWSLQSKKIENDPDFYKIRDDTVRESLFEEWCGERSGNATAEES DSEDNSEDDSEVLEPTKYHYLAQIVANAGTIAPDTIPQDIRKQQKALYKAYKIKEYIP SKRDQDKFVSQLLFYYKTFDLEQRKEIFCDCLRDHERDFTGAVESLRQDKELIDRWQT LLKAPADSSSIEDILLSIEHRCCVSPIVVTEPRYYVVGILEKTVVWVRWLAAEVGPSS RFTPVGAGNEPINPE" gene 833689..834245 /gene="MAY24" /locus_tag="YPR153W" /gene_synonym="EHG1" mRNA join(833689..833693,833828..834245) /gene="MAY24" /locus_tag="YPR153W" /gene_synonym="EHG1" /product="May24p" CDS join(833689..833693,833828..834245) /gene="MAY24" /locus_tag="YPR153W" /gene_synonym="EHG1" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:31797992]" /experiment="EXISTENCE:mutant phenotype:GO:0071464 cellular response to hydrostatic pressure [PMID:31797992]" /note="Peripheral ER membrane protein; putative ER chaperone required for the stability and function of nutrient permeases exposed to high pressure" /codon_start=1 /product="May24p" /protein_id="DAA11565.1" /db_xref="SGD:S000006357" /translation="MRSFVTNNDIPVGYVTPKFPSLYWPINNSKYNTAFLYYISDIWK FSLYWTLIFNGAFYVTAGVYASLTHRKKAGSVWIFVMYVLYGGVQGLTTGTVMGFLIG AIYRSGLFSMSTWVPLCCAVVQILFDVVLSYSMVGSVM" gene 834565..835212 /gene="PIN3" /locus_tag="YPR154W" /gene_synonym="LSB2" mRNA 834565..835212 /gene="PIN3" /locus_tag="YPR154W" /gene_synonym="LSB2" /product="Pin3p" CDS 834565..835212 /gene="PIN3" /locus_tag="YPR154W" /gene_synonym="LSB2" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:23577202]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:23577202]" /experiment="EXISTENCE:direct assay:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:23577202]" /experiment="EXISTENCE:physical interaction:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:23577202]" /note="Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; short-lived protein whose levels increase in response to thermal stress; induces the formation of the [PIN+] and [RNQ+] prions when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication" /codon_start=1 /product="Pin3p" /protein_id="DAA11566.1" /db_xref="SGD:S000006358" /translation="MSASLINRSLTNIRTELDFLKGSNVISNDVYDQINKSLPAKWDP ANAPRNASPASLEYVEALYQFDPQQDGDLGLKPGDKVQLLEKLSPEWYKGSCNGRTGI FPANYVKPAFSGSNGPSNLPPPPQYKAQELQQIPTQNSAASSYQQQPFPPPSTNYYQQ PQQQPQQAPPPQQQQQQQQHQSSHSHLKSFGSKLGNAAIFGAGASIGSDIVNNIF" gene complement(835563..837413) /gene="NCA2" /locus_tag="YPR155C" mRNA complement(835563..837413) /gene="NCA2" /locus_tag="YPR155C" /product="Nca2p" CDS complement(835563..837413) /gene="NCA2" /locus_tag="YPR155C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:7723016]" /experiment="EXISTENCE:mutant phenotype:GO:0016071 mRNA metabolic process [PMID:7723016]" /note="Protein that regulates expression of Fo-F1 ATP synthase subunits; involved in the regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p" /codon_start=1 /product="Nca2p" /protein_id="DAA11567.1" /db_xref="SGD:S000006359" /translation="MIINRRILKSFEEISHSLEESLREVAFDSQQQLIQDVREENEEL SRLQDQLQLIRSIVEKICISIKTDNIDSYCSVPFDLLYNICKDIADPSSFEDGDLQYL VSQAIFEYIILLCYYSVTNECVQGLPAVYEAEQYYKTVSDSILKSFLYCLQNSVSTIR LLSQTVLKDVNKKKLSHQKWSLKALSVDLLEKIRPRINKFMVIRNFRFVGLPKKPIEI ASLVSDIPRGIVHERLDMVTQSSKYYTIKLGQLITEFDQQPEENGMFTEVHLPNYERR LKSLQDFFGLAMSDSNLLDVIRCSAKFHKDHPLRRFTKPSILTRYWPSILLCLLYGPS SVMSLWNSRYFIQDFIKTNVVDFAKGLILNWLWAPLKQVWSTVKHDEGSAISVTSQET LNSDMDSLTRMIVSFVVDNSDSTSNSPIDPILLSTKVEHGDLTEFMEIYETQLHHPIK NIATGGLVRSLLIQLQKTKVDGSMALNGIDKMLKSQQLVFGVVALSPALVILYSSIVA LKRFVKLGNVWSNEKRYREQISISLNNVERVLNYSKQGADADEEHLNQGLLVIEVSNL YKLGSFLIPRSRKKEWFRDVEELVDTNLDSGAHINVVNRIYHVYGRFLIH" gene complement(837909..839777) /gene="TPO3" /locus_tag="YPR156C" mRNA complement(837909..839777) /gene="TPO3" /locus_tag="YPR156C" /product="spermine transporter" CDS complement(837909..839777) /gene="TPO3" /locus_tag="YPR156C" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12562762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000296 spermine transport [PMID:11171066]" /experiment="EXISTENCE:mutant phenotype:GO:0000297 spermine transmembrane transporter activity [PMID:11171066]" /experiment="EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:11171066]" /note="Polyamine transporter of major facilitator superfamily; member of 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to plasma membrane; targeted to vacuole via AP-3 pathway; TPO3 has a paralog, TPO2, that arose from the whole genome duplication" /codon_start=1 /product="spermine transporter" /protein_id="DAA11568.1" /db_xref="SGD:S000006360" /translation="MNRQESINSFNSDETSSLSDVESQQPQQYIPSESGSKSNMAPNQ LKLTRTETVKSLQDMGVSSKAPVPDVNAPQSSKNKIFPEEYTLETPTGLVPVATLHSI GRTSTAISRTRTRQIDGASSPSSNEDALESDNNEKGKEGDSSGANDEAPDLDPEIEFV TFVTGDPENPHNWPAWIRWSYTVLLSILVICVAYGSACISGGLGTVEKKYHVGMEAAI LSVSLMVIGFSLGPLIWSPVSDLYGRRVAYFVSMGLYVIFNIPCALAPNLGSLLACRF LCGVWSSSGLCLVGGSIADMFPSETRGKAIAFFAFAPYVGPVVGPLVNGFISVSTGRM DLIFWVNMAFAGVMWIISSAIPETYAPVILKRKAARLRKETGNPKIMTEQEAQGVSMG EMMRACLLRPLYFSVTEPVLVATCFYVCLIYSLLYAFFFAFPVIFGELYGYKDNLVGL MFIPIVIGALWALATTFYCENKYLQIVKQRKPTPEDRLLGAKIGAPFAAIALWILGAT AYKHIIWVGPASAGLAFGFGMVLIYYSLNNYIIDCYVQYASSALATKVFLRSAGGAAF PLFTIQMYHKLNLHWGSWLLAFISTAMIALPFAFSYWGKGLRHKLSKKDYSIDSIE" gene 841266..842669 /gene="TDA6" /locus_tag="YPR157W" mRNA 841266..842669 /gene="TDA6" /locus_tag="YPR157W" /product="Tda6p" CDS 841266..842669 /gene="TDA6" /locus_tag="YPR157W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="hypothetical protein; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; TDA6 has a paralog, VPS62, that arose from the whole genome duplication" /codon_start=1 /product="Tda6p" /protein_id="DAA11569.1" /db_xref="SGD:S000006361" /translation="MHCVLARILLWFLIVDLSVIRALVLPPLKDYDPLEPLMKRDMAM GQRNRFKVDGQLPPILNSTDVTDDQRSLHTPGEIPSYVINHCPLVHLYSEEKYWPSDI AEYVQNFQIKDKNGNSISTHENLTLHDLKAEYHVDLFGNKTETHIPSSEVFLTSLDDF DKDPKWLLGHLPEYGTGYNSKAPAILIVVDKGNGWVDAFWFFFYPFNHGPFIMGHGPW GNHVGDWEHSLVRFYKGIPKYLWMSAHSSGTGYRYEAVEKFKKLRKRKQQDSDDGGDT ILERPLIFSARGTHANYASAGQHAHDIPFFFMPLSDFTDRGPLWDPSLNFYSYTFDGK TVTPSSEREESLGLDWLHFQGGWGDQQLPARDPRQKWCVAQWKYIGGPRGPLFKKLDR LNLCGGVKKWNFWNGGCPARRLIKKAEGLDSESTDLMGDNCGVLLYRIRPKWLRGILR FLMWRGILCSLMEFFTN" rep_origin 842653..842900 /note="ARS1628; Autonomously Replicating Sequence" /db_xref="SGD:S000118424" gene 843262..844020 /gene="CUR1" /locus_tag="YPR158W" mRNA 843262..844020 /gene="CUR1" /locus_tag="YPR158W" /product="Cur1p" CDS 843262..844020 /gene="CUR1" /locus_tag="YPR158W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22718905|PMID:18833194]" /experiment="EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:22718905]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:22718905]" /experiment="EXISTENCE:mutant phenotype:GO:0006886 intracellular protein transport [PMID:22718905]" /experiment="EXISTENCE:mutant phenotype:GO:0034504 protein localization to nucleus [PMID:22718905]" /experiment="EXISTENCE:physical interaction:GO:0006457 protein folding [PMID:22718905]" /experiment="EXISTENCE:physical interaction:GO:0006886 intracellular protein transport [PMID:22718905]" /experiment="EXISTENCE:physical interaction:GO:0034504 protein localization to nucleus [PMID:22718905]" /experiment="EXISTENCE:physical interaction:GO:0051087 protein-folding chaperone binding [PMID:22718905]" /note="Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication" /codon_start=1 /product="Cur1p" /protein_id="DAA11570.1" /db_xref="SGD:S000006362" /translation="MAAACICQPNLLEINVSDGPLDMIRKKRKIQQPQLRPPLRENKC QPHFSVRKVNQSYIISLHKEITCQLIAEIVKQKLSRIWEKVYIPSYELISDKDGNQIY VEQSVDENRLTSEIMEKLDPNNIDIEAIEILFDDYHLELSRLTNGIIISSANDHFYRE FSFNNIIDDNFKICGTSMSADSFDKIYGVMWIEVPFNGNGLQNDSAVNRVSTSHNQIE ELNDIEQEIRAFNISRSNQESIIKKEVSRRLNGR" mobile_element 844412..850340 /note="YPRWTy1-3; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats" /mobile_element_type="retrotransposon:YPRWTy1-3" /db_xref="SGD:S000007220" repeat_region 844412..844749 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007214" gene 844709..849980 /locus_tag="YPR158W-B" mRNA 844709..849980 /locus_tag="YPR158W-B" /product="gag-pol fusion protein" CDS join(844709..846013,846015..849980) /locus_tag="YPR158W-B" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /codon_start=1 /product="gag-pol fusion protein" /protein_id="DAA11571.1" /db_xref="SGD:S000007364" /translation="MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYD KASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWS FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRPITDDELT FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM TVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNN SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHS DDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQD NTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWV SKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNE SDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKS APSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSE YTNRTLHKFLEKKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWF SAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRG IPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRL TASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHT EDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLA PMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEK RIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFP DPFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRS LEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQL LKMNTWDTDKYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQ SNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRL KKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKD LNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKI PKLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFR FDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAIS DASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLS HLVQELNKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVC YIETKKNIADVMTKPLPIKTFKLLTNKWIH" gene 844709..846031 /locus_tag="YPR158W-A" mRNA 844709..846031 /locus_tag="YPR158W-A" /product="gag protein" CDS 844709..846031 /locus_tag="YPR158W-A" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /codon_start=1 /product="gag protein" /protein_id="DAA11572.1" /db_xref="SGD:S000007363" /translation="MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYD KASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWS FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRPITDDELT FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM TVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNN SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPETY" repeat_region 850003..850340 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007215" repeat_region complement(850357..850512) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007204" rep_origin 850512..850629 /note="ARS1629; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay" /db_xref="SGD:S000130201" mobile_element complement(850629..856554) /note="YPRCTy1-4; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats" /mobile_element_type="retrotransposon:YPRCTy1-4" /db_xref="SGD:S000007209" repeat_region complement(850629..850966) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007205" gene complement(850989..856257) /locus_tag="YPR158C-D" mRNA complement(850989..856257) /locus_tag="YPR158C-D" /product="gag-pol fusion protein" CDS complement(join(850989..854951,854953..856257)) /locus_tag="YPR158C-D" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /codon_start=1 /product="gag-pol fusion protein" /protein_id="DAA11573.1" /db_xref="SGD:S000007362" /translation="MESQQLSNYSPISHGSACASVTSKEVHTNQDPLDVSASKTEECE KASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWS FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM TVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNN SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQELTESTVNHTNHS DDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQD NTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVQYGDFYWV SKRYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNE SDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKS APSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSE YTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFS AIEFSTIVRNSLASPKSKKSASQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGI PGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLT ASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTE DSKPISEINLRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAP MSQSNTHESSHASKSKDFRHSDSYSNNETNHTNVPISSTGGTNNKTVPQISDQETEKR IIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDPPPEPPTELSD SFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSL EPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLL KMKTWDTDRYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDTGMQS NTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLK KSHYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDL NANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIP KLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRF DLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISD ASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSH LVQELNKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCY IETKKNIADVMTKPLPIKTFKLLTNKWIH" gene complement(854935..856257) /locus_tag="YPR158C-C" mRNA complement(854935..856257) /locus_tag="YPR158C-C" /product="gag protein" CDS complement(854935..856257) /locus_tag="YPR158C-C" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /codon_start=1 /product="gag protein" /protein_id="DAA11574.1" /db_xref="SGD:S000007361" /translation="MESQQLSNYSPISHGSACASVTSKEVHTNQDPLDVSASKTEECE KASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWS FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM TVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNN SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPGTY" repeat_region complement(856217..856554) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007206" repeat_region 856545..856885 /note="Ty3 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007217" gene 856902..856974 /locus_tag="YNCP0022W" tRNA 856902..856974 /locus_tag="YNCP0022W" /product="tRNA-Ala" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Alanine tRNA (tRNA-Ala), predicted by tRNAscan-SE analysis; one of 11 nuclear tRNA genes containing the tDNA-anticodon AGC (converted to IGC in the mature tRNA), decodes GCU and GCC codons into alanine, one of 16 nuclear tRNAs for alanine" /db_xref="SGD:S000006520" gene 857583..859745 /gene="KRE6" /locus_tag="YPR159W" /gene_synonym="CWH48" mRNA 857583..859745 /gene="KRE6" /locus_tag="YPR159W" /gene_synonym="CWH48" /product="beta-glucan synthesis-associated protein KRE6" CDS 857583..859745 /gene="KRE6" /locus_tag="YPR159W" /gene_synonym="CWH48" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:17893149]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:21193403]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:7929594]" /experiment="EXISTENCE:direct assay:GO:0030133 transport vesicle [PMID:21193403]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:21193403]" /experiment="EXISTENCE:mutant phenotype:GO:0006078 (1->6)-beta-D-glucan biosynthetic process [PMID:7929594]" /experiment="EXISTENCE:mutant phenotype:GO:0015926 glucosidase activity [PMID:10601196]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:7929594]" /note="Glucosyl hydrolase required for beta-1,6-glucan biosynthesis; type II integral membrane protein that localizes to ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog, SKN1, that arose from the whole genome duplication" /codon_start=1 /product="beta-glucan synthesis-associated protein KRE6" /protein_id="DAA11575.1" /db_xref="SGD:S000006363" /translation="MPLRNLTETHNFSSTNLDTDGTGDDHDGAPLSSSPSFGQQNDNS TNDNAGLTNPFMGSDEESNARDGESLSSSVHYQPQGSDSSLLHDNSRLDLSQNKGVSD YKGYYSRNNSRAVSTANDNSFLQPPHRAIASSPSLNSNLSKNDILSPPEFDRYPLVGS RVTSMTQLNHHGRSPTSSPGNESSASFSSNPFLGEQDFSPFGGYPASSFPLMIDEKEE DDYLHNPDPEEEARLDRRRFIDDFKYMDKRSASGLAGVLLLFLAAIFIFIVLPALTFT GAIDHESNTEEVTYLTQYQYPQLSAIRTSLVDPDTPDTAKTREAMDGSKWELVFSDEF NAEGRTFYDGDDPYWTAPDVHYDATKDLEWYSPDASTTVNGTLQLRMDAFKNHGLYYR SGMLQSWNKVCFTQGALEISANLPNYGRVSGLWPGLWTMGNLGRPGYLASTQGVWPYS YESCDAGITPNQSSPDGISYLPGQKLSICTCDGEDHPNQGVGRGAPEIDVLEGETDTK IGVGIASQSLQIAPFDIWYMPDYDFIEVYNFTTTTMNTYAGGPFQQAVSAVSTLNVTW YEFGEYGGYFQKYAIEYLNDDDNGYIRWFVGDTPTYTIHAKALHPDGNIGWRRISKEP MSIILNLGISNNWAYIDWQYIFFPVVMSIDYVRIYQPSNAISVTCDPSDYPTYDYIQS HLNAFQNANLTTWEDAGYTFPKNILTGKCTSSKFKLSS" gene complement(860314..860415) /locus_tag="YPR159C-A" mRNA complement(860314..860415) /locus_tag="YPR159C-A" /product="hypothetical protein" CDS complement(860314..860415) /locus_tag="YPR159C-A" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /note="hypothetical protein; SWAT-GFP and mCherry fusion proteins localize to the cytosol; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11576.1" /db_xref="SGD:S000028725" /translation="MATLDFTTKPLALVIYMSVVLLLMVGVPLLFSS" gene 860379..860449 /locus_tag="YNCP0023W" tRNA 860379..860449 /locus_tag="YNCP0023W" /product="tRNA-Gly" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /experiment="EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]" /experiment="EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]" /note="Glycine tRNA (tRNA-Gly), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006589" gene 861306..864014 /gene="GPH1" /locus_tag="YPR160W" mRNA 861306..864014 /gene="GPH1" /locus_tag="YPR160W" /product="glycogen phosphorylase" CDS 861306..864014 /gene="GPH1" /locus_tag="YPR160W" /EC_number="2.4.1.1" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:24146988]" /experiment="EXISTENCE:direct assay:GO:0008184 glycogen phosphorylase activity [PMID:1613787]" /experiment="EXISTENCE:mutant phenotype:GO:0005980 glycogen catabolic process [PMID:2657401]" /experiment="EXISTENCE:mutant phenotype:GO:0008184 glycogen phosphorylase activity [PMID:2657401]" /note="Glycogen phosphorylase required for the mobilization of glycogen; non-essential; regulated by cyclic AMP-mediated phosphorylation; phosphorylation by Cdc28p may coordinately regulate carbohydrate metabolism and the cell cycle; expression is regulated by stress-response elements and by the HOG MAP kinase pathway" /codon_start=1 /product="glycogen phosphorylase" /protein_id="DAA11577.1" /db_xref="SGD:S000006364" /translation="MPPASTSTTNDMITEEPTSPHQIPRLTRRLTGFLPQEIKSIDTM IPLKSRALWNKHQVKKFNKAEDFQDRFIDHVETTLARSLYNCDDMAAYEAASMSIRDN LVIDWNKTQQKFTTRDPKRVYYLSLEFLMGRALDNALINMKIEDPEDPAASKGKPREM IKGALDDLGFKLEDVLDQEPDAGLGNGGLGRLAACFVDSMATEGIPAWGYGLRYEYGI FAQKIIDGYQVETPDYWLNSGNPWEIERNEVQIPVTFYGYVDRPEGGKTTLSASQWIG GERVLAVAYDFPVPGFKTSNVNNLRLWQARPTTEFDFAKFNNGDYKNSVAQQQRAESI TAVLYPNDNFAQGKELRLKQQYFWCAASLHDILRRFKKSKRPWTEFPDQVAIQLNDTH PTLAIVELQRVLVDLEKLDWHEAWDIVTKTFAYTNHTVMQEALEKWPVGLFGHLLPRH LEIIYDINWFFLQDVAKKFPKDVDLLSRISIIEENSPERQIRMAFLAIVGSHKVNGVA ELHSELIKTTIFKDFVKFYGPSKFVNVTNGITPRRWLKQANPSLAKLISETLNDPTEE YLLDMAKLTQLGKYVEDKEFLKKWNQVKLNNKIRLVDLIKKENDGVDIINREYLDDTL FDMQVKRIHEYKRQQLNVFGIIYRYLAMKNMLKNGASIEEVAKKYPRKVSIFGGKSAP GYYMAKLIIKLINCVADIVNNDESIEHLLKVVFVADYNVSKAEIIIPASDLSEHISTA GTEASGTSNMKFVMNGGLIIGTVDGANVEITREIGEDNVFLFGNLSENVEELRYNHQY HPQDLPSSLDSVLSYIESGQFSPENPNEFKPLVDSIKYHGDYYLVSDDFESYLATHEL VDQEFHNQRSEWLKKSVLSVANVGFFSSDRCIEEYSDTIWNVEPVT" gene complement(864449..866422) /gene="SGV1" /locus_tag="YPR161C" /gene_synonym="BUR1" mRNA complement(864449..866422) /gene="SGV1" /locus_tag="YPR161C" /gene_synonym="BUR1" /product="cyclin-dependent serine/threonine protein kinase SGV1" CDS complement(864449..866422) /gene="SGV1" /locus_tag="YPR161C" /gene_synonym="BUR1" /EC_number="2.7.11.22" /EC_number="2.7.11.23" /experiment="EXISTENCE:direct assay:GO:0004693 cyclin-dependent protein serine/threonine kinase activity [PMID:10982824]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14749387]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:10982824]" /experiment="EXISTENCE:direct assay:GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity [PMID:11390638]" /experiment="EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:12972617]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:10982824]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:12972617]" /experiment="EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:10982824]" /note="Cyclin (Bur2p)-dependent protein kinase; subunit of the CDK-cyclin BUR kinase complex with Bur2p; regulates Set2p-dependent H3K36 trimethylation; regulates transcriptional elongation through the phosphorylation of the carboxy-terminal domain (CTD) of Rpo21p; stimulates recruitment of the PAF complex through Spt5p CTD phosphorylation; recruits Spt6p to the CTD at the onset of transcription; regulates telomere elongation; regulated by Cak1p; similar to metazoan CDK9 proteins" /codon_start=1 /product="cyclin-dependent serine/threonine protein kinase SGV1" /protein_id="DAA11578.1" /db_xref="SGD:S000006365" /translation="MSDNGSPAVLPKTEFNKYKIGKVKSTPAIQRDAKTNLTYIKLRK RSSEKVYGCTVFQNHYREDEKLGQGTFGEVYKGIHLETQRQVAMKKIIVSVEKDLFPI TAQREITILKRLNHKNIIKLIEMVYDHSPDITNAASSNLHKSFYMILPYMVADLSGVL HNPRINLEMCDIKNMMLQILEGLNYIHCAKFMHRDIKTANILIDHNGVLKLADFGLAR LYYGCPPNLKYPGGAGSGAKYTSVVVTRWYRAPELVLGDKQYTTAVDIWGVGCVFAEF FEKKPILQGKTDIDQGHVIFKLLGTPTEEDWAVARYLPGAELTTTNYKPTLRERFGKY LSETGLDFLGQLLALDPYKRLTAMSAKHHPWFKEDPLPSEKITLPTEESHEADIKRYK EEMHQSLSQRVPTAPRGHIVEKGESPVVKNLGAIPRGPKKDDASFLPPSKNVLAKPPP SKIRELHQNPRPYHVNSGYAKTAIPPPAAPAGVNRYGPNNSSRNNRFSGNSTAPNNSR NPVNRFHPETNVSSKYNKVPLPLGPQSRYQGNSNESRYKNSPNDSRYHNPRYVNKPET NFNRQPQKYSRQESNAPINKNYNPSNGSRNMAGDHHQGSRPSHPQFPISPSQGQHQLT SKPIEKKNGSFKDERAKPDESKEFQNSDIADLY" gene complement(866715..868304) /gene="ORC4" /locus_tag="YPR162C" mRNA complement(866715..868304) /gene="ORC4" /locus_tag="YPR162C" /product="origin recognition complex subunit 4" CDS complement(866715..868304) /gene="ORC4" /locus_tag="YPR162C" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194|PMID:9335335]" /experiment="EXISTENCE:direct assay:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:12897051]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]" /experiment="EXISTENCE:mutant phenotype:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:16716188]" /note="Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; ORC4 has a paralog, RIF2, that arose from the whole genome duplication" /codon_start=1 /product="origin recognition complex subunit 4" /protein_id="DAA11579.1" /db_xref="SGD:S000006366" /translation="MTISEARLSPQVNLLPIKRHSNEEVEETAAILKKRTIDNEKCKD SDPGFGSLQRRLLQQLYGTLPTDEKIIFTYLQDCQQEIDRIIKQSIIQKESHSVILVG PRQSYKTYLLDYELSLLQQSYKEQFITIRLNGFIHSEQTAINGIATQLEQQLQKIHGS EEKIDDTSLETISSGSLTEVFEKILLLLDSTTKTRNEDSGEVDRESITKITVVFIFDE IDTFAGPVRQTLLYNLFDMVEHSRVPVCIFGCTTKLNILEYLEKRVKSRFSQRVIYMP QIQNLDDMVDAVRNLLTVRSEISPWVSQWNETLEKELSDPRSNLNRHIRMNFETFRSL PTLKNSIIPLVATSKNFGSLCTAIKSCSFLDIYNKNQLSNNLTGRLQSLSDLELAILI SAARVALRAKDGSFNFNLAYAEYEKMIKAINSRIPTVAPTTNVGTGQSTFSIDNTIKL WLKKDVKNVWENLVQLDFFTEKSAVGLRDNATAAFYASNYQFQGTMIPFDLRSYQMQI ILQELRRIIPKSNMYYSWTQL" gene complement(868645..869955) /gene="TIF3" /locus_tag="YPR163C" /gene_synonym="RBL3" /gene_synonym="STM1" mRNA complement(868645..869955) /gene="TIF3" /locus_tag="YPR163C" /gene_synonym="RBL3" /gene_synonym="STM1" /product="Tif3p" CDS complement(868645..869955) /gene="TIF3" /locus_tag="YPR163C" /gene_synonym="RBL3" /gene_synonym="STM1" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:7543843]" /experiment="EXISTENCE:direct assay:GO:0003727 single-stranded RNA binding [PMID:23236192]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:7543843]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0033592 RNA strand annealing activity [PMID:7543843]" /experiment="EXISTENCE:direct assay:GO:0034057 RNA strand-exchange activity [PMID:9769100]" /experiment="EXISTENCE:direct assay:GO:0043024 ribosomal small subunit binding [PMID:23236192]" /experiment="EXISTENCE:genetic interaction:GO:0006413 translational initiation [PMID:8404866]" /experiment="EXISTENCE:genetic interaction:GO:0097010 eukaryotic translation initiation factor 4F complex assembly [PMID:23184954]" /experiment="EXISTENCE:mutant phenotype:GO:0001731 formation of translation preinitiation complex [PMID:23236192]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:8404865]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:8404866]" /experiment="EXISTENCE:mutant phenotype:GO:0097010 eukaryotic translation initiation factor 4F complex assembly [PMID:23184954]" /note="Translation initiation factor eIF-4B; RNA recognition motif containing single-stranded RNA binding protein that possesses RNA annealing and strand-exchange activities; stimulates the ATPase and unwinding activities of the RNA helicase eIF4A, in a synergistic manner with eIF4G; promotes assembly of the translation initiation factor complex eIF4F and the 48S preinitiation complex; interacts with Rps20p at the head of the 40S ribosomal subunit and alters the structure of the mRNA entry channel" /codon_start=1 /product="Tif3p" /protein_id="DAA11580.1" /db_xref="SGD:S000006367" /translation="MAPPKKTVKKMDLTSFLNDDTFGSSWAEEDVDLNKITIPIETAN ANTIPLSELAHAKNNSNNTRSGGFGGSFGGRSRLDPALGGGSSDRREEYPVPDAPPYR AVINNIPWDITPEGVQAWVEDGLVKPEAVEEVVLPKNLRDPTRLKGNAFVTLKERADL VAVLKFNGTKLNERTVYVSVAAPRRGGGADVDWSSARGSNFQGDGREDAPDLDWGAAR GSNFRGPRREREEVDIDWTAARGSNFQGSSRPPRREREEVDIDWSAARGSNFQGSSRP PRREREEPDIDWSAARGSNFQSSSRPPRREREEPDIDWSAARGSNFQSSSRPPRRERE KEEPALDWGAARGAQFGKPQQTKNTYKDRSLTNKKTTDEQPKIQKSVYDVLRTEDDDE DEEAEKQNGDAKENKVDAAVEKLQDKTAQLTVEDGDNWEVVGKK" gene 870703..874926 /gene="MMS1" /locus_tag="YPR164W" /gene_synonym="RTT108" /gene_synonym="SLM6" mRNA 870703..874926 /gene="MMS1" /locus_tag="YPR164W" /gene_synonym="RTT108" /gene_synonym="SLM6" /product="Mms1p" CDS 870703..874926 /gene="MMS1" /locus_tag="YPR164W" /gene_synonym="RTT108" /gene_synonym="SLM6" /experiment="EXISTENCE:direct assay:GO:0035361 Cul8-RING ubiquitin ligase complex [PMID:20139071]" /experiment="EXISTENCE:mutant phenotype:GO:0000725 recombinational repair [PMID:18321796]" /experiment="EXISTENCE:mutant phenotype:GO:0010526 transposable element silencing [PMID:11779788]" /experiment="EXISTENCE:mutant phenotype:GO:0031297 replication fork processing [PMID:18704118]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:19390089]" /note="Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay" /codon_start=1 /product="Mms1p" /protein_id="DAA11581.1" /db_xref="SGD:S000006368" /translation="MLGLRTHGLDRYEHYIRRPSDFGKLELQDWLNHKSFRVSPNLLI DSSTTREWNEPELFYQNTEDETWVRPCVGPKLEPSMMMLRYHDSNIGQMPQFCYPISS PINFKPVLKYILQERSELSDGFPQKYNTLIGSLFDIDKNPETLDDSDIEALDDIEMSS DSGNVKEPKIELQALEEIQQKHFSLIVSNNGIFQTGSTSITYIQSGISGSIAIKPNNV AILILLTQPSGHLLSILPLDDGKETYLLQYWNLGQKGQWNIIKHQNEKQFVLIHKELG ICKFFEFHLPFTFQLVNNLTLTDSVIMNGSFFPTNYTDLDPYFIIFITAIRYERIVYF VIEWNNNEIKKKEVYQLTVFDGEKTNMTIPIGLNACLVETPLKFSLVSANQIMSGETE FHSFQLKALKGIKSFFPAPLLLLKLQELHPHTFKKFQYCTIISSSTGNICFCVTERST IVNGNLKFYELTRFKGLKSISPLPSNPINLDSRSSSYVLVVISFSRTLELTLSLEDLR CLDKKDVIKPLKNITFKHTIDSSTEENSQILAFTSSKFYNTHTGSNINDTRNSQVWLT SPNAITQPCIDYKLRKTHQLIHLKQFQIFRHLRIWKCKNLDIALLQRLGINQSNTESS LIFATDAVSNNRIFLLDLTMTTTIDNDDPVQGLINIEDLLCDTENETILLNFTKNNLI QVTRDTIYIDPIGGDKELRKISPGWEFENVTYNDGILIVWNAGLGCVSYIENIDAVDE SGALVSNLSSSKGMSKFFKQLGTVTSVNFQIKESTDDPTKYDIWILLPDCVIRTPFSD WISDSLDFSDVYILSVQQALINGPYFCSLDYESYFEVHTLQNNCFKKGSRCTSRVNFQ GKDIKFRSFGVNQCLAFSAFEIFVINLTPIHDSRELDFYKLKLPHLGNNNSILEVCPD IENNQLFILYSDGLRILELSYLTSNNGNFLLKSTRSKNKKFLYLDKINRMLVLNQDLR EWECIRLSDGKAVGLDSQLLKDDSEEILEIKELPIATEDNPLEKKTVLLISFTSSLKL VLLTAAKNKISNQIIDSYKLDNSRLLNHLVITPRGEIFFLDYKVMGTDNEMSFNKLKV TKHCIDQEERNNTTLRLTLETRFTFKSWSTVKTFTVVGDNIIATTNMGEKLYLIKDFS SSSDESRRVYPLEMYPDSKVQKIIPLNECCFVVAAYCGNRNDLDSRLIFYSLPTIKVG LNNETGSLPDEYGNGRVDDIFEVDFPEGFQFGTMALYDVLHGERHVNRYSEGIRSEND EAEVALRQRRNLLLFWRNHSSTPKPSLRRAATIVYEDHVSSRYFEDISSILGSTAMRT KRLSPYNAVALDKPIQDISYDPAVQTLYVLMADQTIHKFGKDRLPCQDEYEPRWNSGY LVSRRSIVKSDLICEVGLWNLSDNCKNTV" gene 875368..875997 /gene="RHO1" /locus_tag="YPR165W" mRNA 875368..875997 /gene="RHO1" /locus_tag="YPR165W" /product="Rho family GTPase RHO1" CDS 875368..875997 /gene="RHO1" /locus_tag="YPR165W" /EC_number="3.6.5.2" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:8195291]" /experiment="EXISTENCE:direct assay:GO:0000148 1,3-beta-D-glucan synthase complex [PMID:8602515]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:11598008]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:7962098|PMID:11591390]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:15596542]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:1918143]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:8195291]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:8195291]" /experiment="EXISTENCE:direct assay:GO:0007264 small GTPase-mediated signal transduction [PMID:8621575]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:37703377|PMID:36949198]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12660244]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0090334 regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [PMID:36949198|PMID:8662910|PMID:8602515]" /experiment="EXISTENCE:genetic interaction:GO:0007117 budding cell bud growth [PMID:8195291]" /experiment="EXISTENCE:genetic interaction:GO:0007264 small GTPase-mediated signal transduction [PMID:8846785]" /experiment="EXISTENCE:genetic interaction:GO:0030036 actin cytoskeleton organization [PMID:8947028]" /experiment="EXISTENCE:genetic interaction:GO:1903501 positive regulation of mitotic actomyosin contractile ring assembly [PMID:12419188]" /experiment="EXISTENCE:mutant phenotype:GO:0007117 budding cell bud growth [PMID:8195291]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:17302939]" /experiment="EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:15596542]" /experiment="EXISTENCE:mutant phenotype:GO:0032186 cellular bud neck septin ring organization [PMID:26179915]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:10893184]" /experiment="EXISTENCE:mutant phenotype:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:11598008]" /experiment="EXISTENCE:mutant phenotype:GO:0045807 positive regulation of endocytosis [PMID:14593073]" /experiment="EXISTENCE:mutant phenotype:GO:0060178 regulation of exocyst localization [PMID:11283608]" /experiment="EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:8621575]" /experiment="EXISTENCE:mutant phenotype:GO:0090334 regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [PMID:8662910|PMID:8602514|PMID:8602515]" /experiment="EXISTENCE:mutant phenotype:GO:1903395 regulation of secondary cell septum biogenesis [PMID:23878277]" /experiment="EXISTENCE:mutant phenotype:GO:1903501 positive regulation of mitotic actomyosin contractile ring assembly [PMID:12419188]" /experiment="EXISTENCE:physical interaction:GO:0030036 actin cytoskeleton organization [PMID:8947028]" /experiment="EXISTENCE:physical interaction:GO:0031681 G-protein beta-subunit binding [PMID:12660244]" /note="GTP-binding protein of the rho subfamily of Ras-like small GTPases; involved in establishment of cell polarity; regulates protein kinase C (Pkc1p); positive regulatory subunit of the 1,3-beta-D-glucan synthase complex, activating 1,3-beta-glucan synthase (Fks1p and Gsc2p), an enzyme involved in cell wall biosynthesis" /codon_start=1 /product="Rho family GTPase RHO1" /protein_id="DAA11582.1" /db_xref="SGD:S000006369" /translation="MSQQVGNSIRRKLVIVGDGACGKTCLLIVFSKGQFPEVYVPTVF ENYVADVEVDGRRVELALWDTAGQEDYDRLRPLSYPDSNVVLICFSIDLPDSLENVQE KWIAEVLHFCQGVPIILVGCKVDLRNDPQTIEQLRQEGQQPVTSQEGQSVADQIGATG YYECSAKTGYGVREVFEAATRASLMGKSKTNGKAKKNTTEKKKKKCVLL" gene complement(876282..876629) /gene="MRP2" /locus_tag="YPR166C" /gene_synonym="uS14m" mRNA complement(876282..876629) /gene="MRP2" /locus_tag="YPR166C" /gene_synonym="uS14m" /product="mitochondrial 37S ribosomal protein MRP2" CDS complement(876282..876629) /gene="MRP2" /locus_tag="YPR166C" /gene_synonym="uS14m" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit" /codon_start=1 /product="mitochondrial 37S ribosomal protein uS14m MRP2" /protein_id="DAA11583.1" /db_xref="SGD:S000006370" /translation="MGNFRFPIKTKLPPGFINARILRDNFKRQQFKENEILVKSLKFI ARNMNLPTKLRLEAQLKLNALPNYMRSTQIKNRCVDSGHARFVLSDFRLCRYQFRENA LKGNLPGVKKGIW" gene complement(876847..877632) /gene="MET16" /locus_tag="YPR167C" mRNA complement(876847..877632) /gene="MET16" /locus_tag="YPR167C" /product="phosphoadenylyl-sulfate reductase (thioredoxin)" CDS complement(876847..877632) /gene="MET16" /locus_tag="YPR167C" /EC_number="1.8.4.8" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:3060034]" /experiment="EXISTENCE:direct assay:GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity [PMID:3060034]" /experiment="EXISTENCE:direct assay:GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [PMID:3060034]" /experiment="EXISTENCE:mutant phenotype:GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity [PMID:2203779]" /experiment="EXISTENCE:mutant phenotype:GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [PMID:197388]" /note="3'-phosphoadenylsulfate reductase; reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism" /codon_start=1 /product="phosphoadenylyl-sulfate reductase (thioredoxin)" /protein_id="DAA11584.1" /db_xref="SGD:S000006371" /translation="MKTYHLNNDIIVTQEQLDHWNEQLIKLETPQEIIAWSIVTFPHL FQTTAFGLTGLVTIDMLSKLSEKYYMPELLFIDTLHHFPQTLTLKNEIEKKYYQPKNQ TIHVYKPDGCESEADFASKYGDFLWEKDDDKYDYLAKVEPAHRAYKELHISAVFTGRR KSQGSARSQLSIIEIDELNGILKINPLINWTFEQVKQYIDANNVPYNELLDLGYRSIG DYHSTQPVKEGEDERAGRWKGKAKTECGIHEASRFAQFLKQDA" gene 878076..878549 /gene="NUT2" /locus_tag="YPR168W" /gene_synonym="MED10" mRNA 878076..878549 /gene="NUT2" /locus_tag="YPR168W" /gene_synonym="MED10" /product="mediator complex subunit NUT2" CDS 878076..878549 /gene="NUT2" /locus_tag="YPR168W" /gene_synonym="MED10" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9671481]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16452140]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9891034]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:27688401]" /note="Subunit of the RNA polymerase II mediator complex; conserved from yeast to human; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="mediator complex subunit NUT2" /protein_id="DAA11585.1" /db_xref="SGD:S000006372" /translation="MNGNSTNNEQLQQELATTQDQVASIIESFVELGVSIYDFPGTPE ATKGMITNLQRNVDRLYKLNVRSNDPQSSLSKVDIPLEVVQYIEDGRNPDIYTREFVE AIRRSNQYQRGKMHGLKQLRDSLADKIVDEFPELKEPVEDIIKRTSPIDNVSNTH" gene 878690..880168 /gene="JIP5" /locus_tag="YPR169W" mRNA 878690..880168 /gene="JIP5" /locus_tag="YPR169W" /product="Jip5p" CDS 878690..880168 /gene="JIP5" /locus_tag="YPR169W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095|PMID:14690591]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:19806183]" /note="Protein required for biogenesis of the large ribosomal subunit; required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein; essential gene" /codon_start=1 /product="Jip5p" /protein_id="DAA11586.1" /db_xref="SGD:S000006373" /translation="MAKSKKKTDVVDSTNLPILELLSLKAPIFQSLLHPELPIIITGF GTGHIVCHRYDPAKLQSHLDRRRRIDTATTGKDAKKGVCPWIRLDIDLETGDLKFVDI EEQQQQKQTGKDEDLGVKTLWKTKRHKGSVRAMCFDSKGDNIFSVGSDNVLKKANTMT GKVVKKVNLSSLFNSEEKKNDKFTKLCASQTHPFILIGDESGNIHVINSENLALSNSI RSIHFGDSINDIFHFDKRSAYKFISLGQTTLAYFDVRDKDAKPNVAGNEDGKILISDD QEDEVLCGCFVDPEVADTLLCGMGEGIVTVWKPNKNDLEDQMSRIKISKDESIDCIVP TLQDDNCVWCGCSNGNIYKVNAKLGKVVEIRNHSELDEVSFVDLDFEYRVVSGGLENI KIWELSSDDVEENASVESDSDEPLSHSDEDLSDDTSSDDETTLVGLSKEELLDELDKD LKEDHQEEKESNSKSVKKRKIMKENNKKKDLYEHGIKKFDDL" gene complement(880296..880369) /locus_tag="YNCP0024C" tRNA complement(880296..880369) /locus_tag="YNCP0024C" /product="tRNA-Ile" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Isoleucine tRNA (tRNA-Ile), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006612" repeat_region 880386..880726 /note="Ty3 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007218" rep_origin 880861..881108 /note="ARS1630; Autonomously Replicating Sequence" /db_xref="SGD:S000118425" repeat_region complement(881487..881830) /note="Ty4 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007207" gene 883239..883595 /locus_tag="YPR170W-B" mRNA join(883239..883387,883487..883595) /locus_tag="YPR170W-B" /product="hypothetical protein" CDS join(883239..883387,883487..883595) /locus_tag="YPR170W-B" /note="Putative, non-essential component vacuolar ATPase; conserved in fungi; SWAT-GFP fusion protein localizes to vacuole membrane; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11587.1" /db_xref="SGD:S000028515" /translation="MRPVVSTGKAWCCTVLSAFGVVILSVIAHLFNTNHESFVGSIND PEDGPAVAHTVYLAALVYLVFFVFCGFQVYLARRKPSIELR" gene 883828..885558 /gene="BSP1" /locus_tag="YPR171W" mRNA 883828..885558 /gene="BSP1" /locus_tag="YPR171W" /product="Bsp1p" CDS 883828..885558 /gene="BSP1" /locus_tag="YPR171W" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12606027]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12606027]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:12606027]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:38088874|PMID:12606027]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:12606027]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:38088874]" /experiment="EXISTENCE:direct assay:GO:0110085 mitotic actomyosin contractile ring [PMID:38088874]" /experiment="EXISTENCE:mutant phenotype:GO:0044379 protein localization to actin cortical patch [PMID:38088874]" /experiment="EXISTENCE:mutant phenotype:GO:0051015 actin filament binding [PMID:38088874]" /experiment="EXISTENCE:mutant phenotype:GO:0051666 actin cortical patch localization [PMID:12606027]" /experiment="EXISTENCE:mutant phenotype:GO:1904498 protein localization to mitotic actomyosin contractile ring [PMID:38088874]" /note="Actin filament binding protein; regulates actin filament capping by recruiting capping protein to endocytic sites and to the cytokinetic actin ring; interacts with the capping protein complex; adapter that links synaptojanins, Inp52p and Inp53p, to the cortical actin cytoskeleton; contains two WH2-like actin binding domains and a C-terminal capping protein interaction (CPI) motif" /codon_start=1 /product="Bsp1p" /protein_id="DAA11588.1" /db_xref="SGD:S000006375" /translation="MTKYERDPELVNFLSKVEDLNSKRYSNIPSSKPAGEALSPVRSH NSGEYRRADMMTGKNVEGCDNLAYRSAYNYEMTFSPKKTHYSLSELNLERITPRPDLE GSASQKEKKFLISEEDYLLLQKLKASQTYNDSNADKNLPSFEKGPRMPSRGRPRPREK EIITIQYDFELPGRADIPSSSSSSSPPPLPTRRDHIKITDGNEEKPLLPTRPNKAEVT ESPSSRSIKPDAVVPERVKPAPPVSRSTKPASFLSSLEDNKLTKAKSYNSEMETPKTT VKSSHIDYLDSIQLKPTTLSPTMKNKPKPTPPSPPAKRIPRSESFIKSMLNSNLTTTS KPSLPEKPQKLRNANLAAHKTKPSIPPKKVELNIVLPELRPVETSPTKQNFENSIDLP KLRSSNRNIKKEEEDSIPEAIKGIQNLKKTKQQKPAIPQKKSFLTNNSKNTTLKNGDD INKLNDEIEALSLRNNLKKRPPTAPQRKISLPEALRKVELMKKSKTEPVLESSNELSI NAKLDAIIASRNLRASNTLPELSGVNTNIATSDKYTTSRDETVKETKPLVHPNKNRTR GPRRKLPTRV" gene 885796..886398 /locus_tag="YPR172W" mRNA 885796..886398 /locus_tag="YPR172W" /product="pyridoxal 5'-phosphate synthase" CDS 885796..886398 /locus_tag="YPR172W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /note="hypothetical protein; predicted to encode a pyridoxal 5'-phosphate synthase based on sequence similarity but purified protein does not possess this activity, nor does it bind flavin mononucleotide (FMN); transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication" /codon_start=1 /product="pyridoxal 5'-phosphate synthase" /protein_id="DAA11589.1" /db_xref="SGD:S000006376" /translation="MAWTSTLPAHLLNLIKNSKYVHVATCSKDCIPSVALMNYIYVPG EKLFGQTDNKNDYIIFVSPQDTQKFYNIKENPKVALLFHDWIIANNLSVGKESISGTP TPTSIPHEEQRQSELLNLLQELNQAELNQMSASIGGETEIVNPESEESKYYKDLILKA NPDAKAFIFEKNTAVVKVRIDNARVSNNENRTMFLSKGKS" gene complement(886524..887837) /gene="VPS4" /locus_tag="YPR173C" /gene_synonym="CSC1" /gene_synonym="DID6" /gene_synonym="END13" /gene_synonym="GRD13" /gene_synonym="VPL4" /gene_synonym="VPT10" mRNA complement(886524..887837) /gene="VPS4" /locus_tag="YPR173C" /gene_synonym="CSC1" /gene_synonym="DID6" /gene_synonym="END13" /gene_synonym="GRD13" /gene_synonym="VPL4" /gene_synonym="VPT10" /product="AAA family ATPase VPS4" CDS complement(886524..887837) /gene="VPS4" /locus_tag="YPR173C" /gene_synonym="CSC1" /gene_synonym="DID6" /gene_synonym="END13" /gene_synonym="GRD13" /gene_synonym="VPL4" /gene_synonym="VPT10" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:9606181]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:9606181]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:16601096]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:16505166|PMID:9155008|PMID:9606181]" /experiment="EXISTENCE:direct assay:GO:0061709 reticulophagy [PMID:31802527]" /experiment="EXISTENCE:genetic interaction:GO:0016125 sterol metabolic process [PMID:16096648]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:9606181]" /experiment="EXISTENCE:mutant phenotype:GO:0016125 sterol metabolic process [PMID:16096648]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:17428789]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:9155008]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:16505166]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:8649377]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:9211789|PMID:9606181]" /experiment="EXISTENCE:mutant phenotype:GO:0070676 intralumenal vesicle formation [PMID:19234443]" /note="AAA-ATPase involved in multivesicular body (MVB) protein sorting; ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism" /codon_start=1 /product="AAA family ATPase VPS4" /protein_id="DAA11590.1" /db_xref="SGD:S000006377" /translation="MSTGDFLTKGIELVQKAIDLDTATQYEEAYTAYYNGLDYLMLAL KYEKNPKSKDLIRAKFTEYLNRAEQLKKHLESEEANAAKKSPSAGSGSNGGNKKISQE EGEDNGGEDNKKLRGALSSAILSEKPNVKWEDVAGLEGAKEALKEAVILPVKFPHLFK GNRKPTSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESEKLVKQLF AMARENKPSIIFIDEVDALTGTRGEGESEASRRIKTELLVQMNGVGNDSQGVLVLGAT NIPWQLDSAIRRRFERRIYIPLPDLAARTTMFEINVGDTPCVLTKEDYRTLGAMTEGY SGSDIAVVVKDALMQPIRKIQSATHFKDVSTEDDETRKLTPCSPGDDGAIEMSWTDIE ADELKEPDLTIKDFLKAIKSTRPTVNEDDLLKQEQFTRDFGQEGN" gene complement(888043..888708) /gene="CSA1" /locus_tag="YPR174C" mRNA complement(888043..888708) /gene="CSA1" /locus_tag="YPR174C" /product="Csa1p" CDS complement(888043..888708) /gene="CSA1" /locus_tag="YPR174C" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:1902365 positive regulation of protein localization to spindle pole body [PMID:32553169]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication" /codon_start=1 /product="Csa1p" /protein_id="DAA11591.1" /db_xref="SGD:S000006378" /translation="MGIQEKTLGIRKERKLVVVPRERNHVRHASQRTRSKNYKNISKK RAQQHAFGFNIAKTLAKIQAFVWGSPADEEEESVVPLSKNSQDCVPLQWQAKFAQLRQ QLHSTQKELQFVKEKCHLLQSVLDDANIDQRYLESRRDMKNIERDNLKPTENLPPSPV RAVNPLVTSSPIHMSPLQSRQRPVSSLQPPKGPNFYAKYPKLPQTNILRESPTEDSVP HAE" gene 888974..891043 /gene="DPB2" /locus_tag="YPR175W" mRNA 888974..891043 /gene="DPB2" /locus_tag="YPR175W" /product="DNA polymerase epsilon noncatalytic subunit" CDS 888974..891043 /gene="DPB2" /locus_tag="YPR175W" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:16916794|PMID:14622139]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:14622139]" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:12882968]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0006261 DNA-templated DNA replication [PMID:12882968|PMID:14622139|PMID:16369485]" /experiment="EXISTENCE:direct assay:GO:0008622 epsilon DNA polymerase complex [PMID:2406268|PMID:12571237|PMID:14673157]" /experiment="EXISTENCE:direct assay:GO:0030337 DNA polymerase processivity factor activity [PMID:16369485]" /experiment="EXISTENCE:direct assay:GO:0042276 error-prone translesion synthesis [PMID:19776424]" /experiment="EXISTENCE:mutant phenotype:GO:0042276 error-prone translesion synthesis [PMID:19776424]" /experiment="EXISTENCE:mutant phenotype:GO:0045005 DNA-templated DNA replication maintenance of fidelity [PMID:19463834|PMID:18245343]" /note="Second largest subunit of DNA polymerase II (DNA polymerase epsilon); required for maintenance of fidelity of chromosomal replication; essential motif in C-terminus is required for formation of the four-subunit Pol epsilon; expression peaks at the G1/S phase boundary; Cdc28p substrate" /codon_start=1 /product="DNA polymerase epsilon noncatalytic subunit" /protein_id="DAA11592.1" /db_xref="SGD:S000006379" /translation="MFGSGNVLPVKIQPPLLRPLAYRVLSRKYGLSIKSDGLSALAEF VGTNIGANWRQGPATIKFLEQFAAVWKQQERGLFIDQSGVKEVIQEMKEREKVEWSHE HPIQHEENILGRTDDDENNSDDEMPIAADSSLQNVSLSSPMRQPTERDEYKQPFKPES SKALDWRDYFKVINASQQQRFSYNPHKMQFIFVPNKKQNGLGGIAGFLPDIEDKVQMF LTRYYLTNDRVMRNENFQNSDMFNPLSSMVSLQNELSNTNRQQQSSSMSITPIKNLLG RDAQNFLLLGLLNKNFKGNWSLEDPSGSVEIDISQTIPTQGHYYVPGCMVLVEGIYYS VGNKFHVTSMTLPPGERREITLETIGNLDLLGIHGISNNNFIARLDKDLKIRLHLLEK ELTDHKFVILGANLFLDDLKIMTALSKILQKLNDDPPTLLIWQGSFTSVPVFASMSSR NISSSTQFKNNFDALATLLSRFDNLTENTTMIFIPGPNDLWGSMVSLGASGTLPQDPI PSAFTKKINKVCKNVVWSSNPTRIAYLSQEIVIFRDDLSGRFKRHRLEFPFNESEDVY TENDNMMSKDTDIVPIDELVKEPDQLPQKVQETRKLVKTILDQGHLSPFLDSLRPISW DLDHTLTLCPIPSTMVLCDTTSAQFDLTYNGCKVINPGSFIHNRRARYMEYVPSSKKT IQEEIYI" gene complement(891101..892078) /gene="BET2" /locus_tag="YPR176C" mRNA complement(891101..892078) /gene="BET2" /locus_tag="YPR176C" /product="Rab geranylgeranyltransferase BET2" CDS complement(891101..892078) /gene="BET2" /locus_tag="YPR176C" /EC_number="2.5.1.60" /experiment="EXISTENCE:direct assay:GO:0004663 Rab geranylgeranyltransferase activity [PMID:8756702]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005968 Rab-protein geranylgeranyltransferase complex [PMID:8183917|PMID:8756702|PMID:8583924]" /experiment="EXISTENCE:direct assay:GO:0018344 protein geranylgeranylation [PMID:8756702]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:1903184]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:3312234|PMID:8232541]" /experiment="EXISTENCE:physical interaction:GO:0005968 Rab-protein geranylgeranyltransferase complex [PMID:8232542]" /note="Beta subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; human homolog RABGGTB can complement yeast BET2 mutant" /codon_start=1 /product="Rab geranylgeranyltransferase BET2" /protein_id="DAA11593.1" /db_xref="SGD:S000006380" /translation="MSGSLTLLKEKHIRYIESLDTKKHNFEYWLTEHLRLNGIYWGLT ALCVLDSPETFVKEEVISFVLSCWDDKYGAFAPFPRHDAHLLTTLSAVQILATYDALD VLGKDRKVRLISFIRGNQLEDGSFQGDRFGEVDTRFVYTALSALSILGELTSEVVDPA VDFVLKCYNFDGGFGLCPNAESHAAQAFTCLGALAIANKLDMLSDDQLEEIGWWLCER QLPEGGLNGRPSKLPDVCYSWWVLSSLAIIGRLDWINYEKLTEFILKCQDEKKGGISD RPENEVDVFHTVFGVAGLSLMGYDNLVPIDPIYCMPKSVTSKFKKYPYK" gene 892332..893729 /gene="PRP4" /locus_tag="YPR178W" /gene_synonym="RNA4" mRNA 892332..893729 /gene="PRP4" /locus_tag="YPR178W" /gene_synonym="RNA4" /product="U4/U6-U5 snRNP complex subunit PRP4" CDS 892332..893729 /gene="PRP4" /locus_tag="YPR178W" /gene_synonym="RNA4" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419|PMID:10377396]" /experiment="EXISTENCE:mutant phenotype:GO:0000393 spliceosomal conformational changes to generate catalytic conformation [PMID:28864812]" /experiment="EXISTENCE:mutant phenotype:GO:0034247 snoRNA splicing [PMID:8202378]" /note="Splicing factor; component of the U4/U6-U5 snRNP complex" /codon_start=1 /product="U4/U6-U5 snRNP complex subunit PRP4" /protein_id="DAA11594.1" /db_xref="SGD:S000006382" /translation="MSKYIALENLPVDLQHKGATQNESTADILKQLPHERLQAVLEKI PEEDLEVRRLLSILKKPEVVENEDVQQRRIRLAEILMVDEIDLENINNMENINGEEVD EEDDEDFFTPATSELIFARRFLINYSLERSRKRLQKEMERHQKFNTRQELLSRRTELQ RMANLELAGSQLVSTKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHV GKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPS GKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLW DIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAH RNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSH FLVSGGWDRSIKLWN" gene complement(893797..895764) /gene="HDA3" /locus_tag="YPR179C" /gene_synonym="PLO1" mRNA complement(893797..895764) /gene="HDA3" /locus_tag="YPR179C" /gene_synonym="PLO1" /product="Hda3p" CDS complement(893797..895764) /gene="HDA3" /locus_tag="YPR179C" /gene_synonym="PLO1" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:19573535]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:16415367]" /experiment="EXISTENCE:direct assay:GO:0004407 histone deacetylase activity [PMID:19573535]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0070823 HDA1 complex [PMID:11287668|PMID:8663039]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11287668]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:16415367]" /experiment="EXISTENCE:mutant phenotype:GO:0031047 regulatory ncRNA-mediated gene silencing [PMID:18022365]" /experiment="EXISTENCE:physical interaction:GO:0070823 HDA1 complex [PMID:11287668]" /note="Subunit of HDA1 histone deacetylase complex; tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for activity of complex; relocalizes to cytosol in response to hypoxia; similar to Hda2p; the HDA1 histone deacetylase complex regulates aging through trehalose metabolism" /codon_start=1 /product="Hda3p" /protein_id="DAA11595.1" /db_xref="SGD:S000006383" /translation="MDLLRILDTKPIPTIVDATTLGISGNTSGDYWLPTTMSLYQKEL TDQIVSLHYSDILRYFETSHYKEDVILESMKTMCLNGSLVATHPYLLIDHYMPKSLIT RDVPAHLAENSGKFSVLRDLINLVQEYETETAIVCRPGRTMDLLEALLLGNKVHIKRY DGHSIKSKQKANDFSCTVHLFSSEGINFTKYPIKSKARFDMLICLDTTVDTSQKDIQY LLQYKRERKGLERYAPIVRLVAINSIDHCRLFFGKKFDKNSREYLENVTAAMVILRDR LGTLPPDLRPIYSQKLHYLVEWLENPTVPWPLPDIYPLKQYTSMDVERSLLTEVHFKK SDDQLEDAFSNCSKKRGRHGANKAASSTVAGIEDNITPSFYSTKRLKNDYYTNPLKQD MTQLTGITTADNSSNVNYHLSSGIITHKLIQSMGEVYMDICVQKQELDDYSCLDDLQN DHLKFFSNEDEKIIKEYETVLRTNNENLNRSHELEVENNLKFSQIETLEKDIETLKGS LMAQGETLSKLKDAFVKTDNVQDEIEKEERVSVSRDTEKKYMEQEIKRAVDAIRENEE ETHKLNEKQNGLESELKLKFEKSEISTKELNEKIGFLKKELKLENDLNEELVGQLSKT MDNLENLTIPRVRTQNGNTKKKSRAKKPGNV" gene 895961..897004 /gene="AOS1" /locus_tag="YPR180W" /gene_synonym="RHC31" mRNA 895961..897004 /gene="AOS1" /locus_tag="YPR180W" /gene_synonym="RHC31" /product="E1 ubiquitin-activating protein AOS1" CDS 895961..897004 /gene="AOS1" /locus_tag="YPR180W" /gene_synonym="RHC31" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0016925 protein sumoylation [PMID:9312010]" /experiment="EXISTENCE:direct assay:GO:0019948 SUMO activating enzyme activity [PMID:9312010]" /experiment="EXISTENCE:physical interaction:GO:0031510 SUMO activating enzyme complex [PMID:9312010]" /note="Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability; relocalizes to the cytosol in response to hypoxia" /codon_start=1 /product="E1 ubiquitin-activating protein AOS1" /protein_id="DAA11596.1" /db_xref="SGD:S000006384" /translation="MDMKVEKLSEDEIALYDRQIRLWGMTAQANMRSAKVLLINLGAI GSEITKSIVLSGIGHLTILDGHMVTEEDLGSQFFIGSEDVGQWKIDATKERIQDLNPR IELNFDKQDLQEKDEEFFQQFDLVVATEMQIDEAIKINTLTRKLNIPLYVAGSNGLFA YVFIDLIEFISEDEKLQSVRPTTVGPISSNRSIIEVTTRKDEEDEKKTYERIKTKNCY RPLNEVLSTATLKEKMTQRQLKRVTSILPLTLSLLQYGLNQKGKAISFEQMKRDAAVW CENLGVPATVVKDDYIQQFIKQKGIEFAPVAAIIGGAVAQDVINILGKRLSPLNNFIV FDGITLDMPLFEF" gene complement(897361..899667) /gene="SEC23" /locus_tag="YPR181C" mRNA complement(897361..899667) /gene="SEC23" /locus_tag="YPR181C" /product="GTPase-activating protein SEC23" CDS complement(897361..899667) /gene="SEC23" /locus_tag="YPR181C" /experiment="EXISTENCE:direct assay:GO:0003400 regulation of COPII vesicle coating [PMID:8451644]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:8451644]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030127 COPII vesicle coat [PMID:8004676]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:11694599]" /experiment="EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:31273116]" /note="GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p" /codon_start=1 /product="GTPase-activating protein SEC23" /protein_id="DAA11597.1" /db_xref="SGD:S000006385" /translation="MDFETNEDINGVRFTWNVFPSTRSDANSNVVPVGCLYTPLKEYD ELNVAPYNPVVCSGPHCKSILNPYCVIDPRNSSWSCPICNSRNHLPPQYTNLSQENMP LELQSTTIEYITNKPVTVPPIFFFVVDLTSETENLDSLKESIITSLSLLPPNALIGLI TYGNVVQLHDLSSETIDRCNVFRGDREYQLEALTEMLTGQKPTGPGGAASHLPNAMNK VTPFSLNRFFLPLEQVEFKLNQLLENLSPDQWSVPAGHRPLRATGSALNIASLLLQGC YKNIPARIILFASGPGTVAPGLIVNSELKDPLRSHHDIDSDHAQHYKKACKFYNQIAQ RVAANGHTVDIFAGCYDQIGMSEMKQLTDSTGGVLLLTDAFSTAIFKQSYLRLFAKDE EGYLKMAFNGNMAVKTSKDLKVQGLIGHASAVKKTDANNISESEIGIGATSTWKMASL SPYHSYAIFFEIANTAANSNPMMSAPGSADRPHLAYTQFITTYQHSSGTNRIRVTTVA NQLLPFGTPAIAASFDQEAAAVLMARIAVHKAETDDGADVIRWLDRTLIKLCQKYADY NKDDPQSFRLAPNFSLYPQFTYYLRRSQFLSVFNNSPDETAFYRHIFTREDTTNSLIM IQPTLTSFSMEDDPQPVLLDSISVKPNTILLLDTFFFILIYHGEQIAQWRKAGYQDDP QYADFKALLEEPKLEAAELLVDRFPLPRFIDTEAGGSQARFLLSKLNPSDNYQDMARG GSTIVLTDDVSLQNFMTHLQQVAVSGQA" gene 900194..900454 /gene="SMX3" /locus_tag="YPR182W" mRNA 900194..900454 /gene="SMX3" /locus_tag="YPR182W" /product="mRNA splicing protein SMX3" CDS 900194..900454 /gene="SMX3" /locus_tag="YPR182W" /experiment="EXISTENCE:curator inference:GO:0000398 mRNA splicing, via spliceosome []" /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720285|PMID:11720284]" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9630245]" /experiment="EXISTENCE:direct assay:GO:0005686 U2 snRNP [PMID:9012791]" /experiment="EXISTENCE:direct assay:GO:0008266 poly(U) RNA binding [PMID:12618433]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419|PMID:10377396]" /experiment="EXISTENCE:physical interaction:GO:1990935 splicing factor binding [PMID:9528767]" /note="Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F" /codon_start=1 /product="mRNA splicing protein SMX3" /protein_id="DAA11598.1" /db_xref="SGD:S000006386" /translation="MSESSDISAMQPVNPKPFLKGLVNHRVGVKLKFNSTEYRGTLVS TDNYFNLQLNEAEEFVAGVSHGTLGEIFIRCNNVLYIRELPN" gene 900755..901558 /gene="DPM1" /locus_tag="YPR183W" /gene_synonym="SED3" mRNA 900755..901558 /gene="DPM1" /locus_tag="YPR183W" /gene_synonym="SED3" /product="dolichyl-phosphate beta-D-mannosyltransferase" CDS 900755..901558 /gene="DPM1" /locus_tag="YPR183W" /gene_synonym="SED3" /EC_number="2.4.1.83" /experiment="EXISTENCE:direct assay:GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity [PMID:3053713|PMID:16549409]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:1803815|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:10419517]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:2146492]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:2146492]" /note="Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane; catalyzes formation of Dol-P-Man from Dol-P and GDP-Man; required for biosynthesis of glycosyl phosphatidylinositol (GPI) membrane anchor, as well as O-mannosylation and protein N- and O-linked glycosylation; human homolog DPM1 can complement yeast mutant strains" /codon_start=1 /product="dolichyl-phosphate beta-D-mannosyltransferase" /protein_id="DAA11599.1" /db_xref="SGD:S000006387" /translation="MSIEYSVIVPAYHEKLNIKPLTTRLFAGMSPEMAKKTELIFVDD NSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLKGFYEAKGQYLVCMDADLQHPP ETVPKLFESLHDHAFTLGTRYAPGVGIDKDWPMYRRVISSTARMMARPLTIASDPMSG FFGLQKKYLENCNPRDINSQGFKIALELLAKLPLPRDPRVAIGEVPFTFGVRTEGESK LSGKVIIQYLQQLKELYVFKFGANNLILFITFWSILFFYVCYQLYHLVF" gene 902044..906654 /gene="GDB1" /locus_tag="YPR184W" mRNA 902044..906654 /gene="GDB1" /locus_tag="YPR184W" /product="bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase" CDS 902044..906654 /gene="GDB1" /locus_tag="YPR184W" /EC_number="2.4.1.25" /EC_number="3.2.1.33" /experiment="EXISTENCE:direct assay:GO:0004134 4-alpha-glucanotransferase activity [PMID:11094287]" /experiment="EXISTENCE:direct assay:GO:0004135 amylo-alpha-1,6-glucosidase activity [PMID:11094287]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0004134 4-alpha-glucanotransferase activity [PMID:11094287]" /experiment="EXISTENCE:mutant phenotype:GO:0004135 amylo-alpha-1,6-glucosidase activity [PMID:11094287]" /experiment="EXISTENCE:mutant phenotype:GO:0005980 glycogen catabolic process [PMID:11094287]" /note="Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase" /protein_id="DAA11600.1" /db_xref="SGD:S000006388" /translation="MNRSLLLRLSDTGEPITSCSYGKGVLTLPPIPLPKDAPKDQPLY TVKLLVSAGSPVARDGLVWTNCPPDHNTPFKRDKFYKKIIHSSFHEDDCIDLNVYAPG SYCFYLSFRNDNEKLETTRKYYFVALPMLYINDQFLPLNSIALQSVVSKWLGSDWEPI LSKIAAKNYNMVHFTPLQERGESNSPYSIYDQLQFDQEHFKSPEDVKNLVEHIHRDLN MLSLTDIVFNHTANNSPWLVEHPEAGYNHITAPHLISAIELDQELLNFSRNLKSWGYP TELKNIEDLFKIMDGIKVHVLGSLKLWEYYAVNVQTALRDIKAHWNDESNESYSFPEN IKDISSDFVKLASFVKDNVTEPNFGTLGERNSNRINVPKFIQLLKLINDGGSDDSESS LATAQNILNEVNLPLYREYDDDVSEILEQLFNRIKYLRLDDGGPKQGPVTVDVPLTEP YFTRFKGKDGTDYALANNGWIWNGNPLVDFASQNSRAYLRREVIVWGDCVKLRYGKSP EDSPYLWERMSKYIEMNAKIFDGFRIDNCHSTPIHVGEYFLDLARKYNPNLYVVAELF SGSETLDCLFVERLGISSLIREAMQAWSEEELSRLVHKHGGRPIGSYKFVPMDDFSYP ADINLNEEHCFNDSNDNSIRCVSEIMIPKILTATPPHALFMDCTHDNETPFEKRTVED TLPNAALVALCSSAIGSVYGYDEIFPHLLNLVTEKRHYDISTPTGSPSIGITKVKATL NSIRTSIGEKAYDIEDSEMHVHHQGQYITFHRMDVKSGKGWYLIARMKFSDNDDPNET LPPVVLNQSTCSLRFSYALERVGDEIPNDDKFIKGIPTKLKELEGFDISYDDSKKIST IKLPNEFPQGSIAIFETQQNGVDESLDHFIRSGALKATSSLTLESINSVLYRSEPEEY DVSAGEGGAYIIPNFGKPVYCGLQGWVSVLRKIVFYNDLAHPLSANLRNGHWALDYTI SRLNYYSDEAGINEVQNWLRSRFDRVKKLPSYLVPSYFALIIGILYGCCRLKAIQLMS RNIGKSTLFVQSLSMTSIQMVSRMKSTSILPGENVPSMAAGLPHFSVNYMRCWGRDVF ISLRGMLLTTGRFDEAKAHILAFAKTLKHGLIPNLLDAGRNPRYNARDAAWFFLQAVQ DYVYIVPDGEKILQEQVTRRFPLDDTYIPVDDPRAFSYSSTLEEIIYEILSRHAKGIK FREANAGPNLDRVMTDKGFNVEIHVDWSTGLIHGGSQYNCGTWMDKMGESEKAGSVGI PGTPRDGAAIEINGLLKSALRFVIELKNKGLFKFSDVETQDGGRIDFTEWNQLLQDNF EKRYYVPEDPSQDADYDVSAKLGVNRRGIYRDLYKSGKPYEDYQLRPNFAIAMTVAPE LFVPEHAIKAITIADEVLRGPVGMRTLDPSDYNYRPYYNNGEDSDDFATSKGRNYHQG PEWVWLYGYFLRAFHHFHFKTSPRCQNAAKEKPSSYLYQQLYYRLKGHRKWIFESVWA GLTELTNKDGEVCNDSSPTQAWSSACLLDLFYDLWDAYEDDS" regulatory 907211..907351 /regulatory_class="other" /note="Upstream open reading frame (uORF) in 5' untranslated region of ATG13 gene, regulate translation" gene 907218..909434 /gene="ATG13" /locus_tag="YPR185W" /gene_synonym="APG13" mRNA 907218..909434 /gene="ATG13" /locus_tag="YPR185W" /gene_synonym="APG13" /product="serine/threonine protein kinase regulatory subunit ATG13" CDS 907218..909434 /gene="ATG13" /locus_tag="YPR185W" /gene_synonym="APG13" /experiment="EXISTENCE:direct assay:GO:0000045 autophagosome assembly [PMID:18725539]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:29540529]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0019887 protein kinase regulator activity [PMID:22885598]" /experiment="EXISTENCE:direct assay:GO:0070016 armadillo repeat domain binding [PMID:31512555]" /experiment="EXISTENCE:direct assay:GO:0120095 vacuole-isolation membrane contact site [PMID:23549786]" /experiment="EXISTENCE:direct assay:GO:1990316 Atg1/ULK1 kinase complex [PMID:26753620]" /experiment="EXISTENCE:genetic interaction:GO:0034497 protein localization to phagophore assembly site [PMID:23509291]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:32508216]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:18725539]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:9224892]" /experiment="EXISTENCE:mutant phenotype:GO:0019887 protein kinase regulator activity [PMID:10995454]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:27768871]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /experiment="EXISTENCE:mutant phenotype:GO:0071211 protein targeting to vacuole involved in autophagy [PMID:27768871]" /experiment="EXISTENCE:mutant phenotype:GO:0071255 Cvt vesicle assembly [PMID:10837477]" /experiment="EXISTENCE:physical interaction:GO:1990316 Atg1/ULK1 kinase complex [PMID:15743910]" /note="Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; contains a HORMA domain required for autophagy and for recruitment of the phosphatidylinositol 3-kinase complex subunit Atg14p to the pre-autophagosomal structure" /codon_start=1 /product="serine/threonine protein kinase regulatory subunit ATG13" /protein_id="DAA11601.1" /db_xref="SGD:S000006389" /translation="MVAEEDIEKQVLQLIDSFFLKTTLLICSTESSRYQSSTENIFLF DDTWFEDHSELVSELPEIISKWSHYDGRKELPPLVVETYLDLRQLNSSHLVRLKDHEG HLWNVCKGTKKQEIVMERWLIELDNSSPTFKSYSEDETDVNELSKQLVLLFRYLLTLI QLLPTTELYQLLIKSYNGPQNEGSSNPITSTGPLVSIRTCVLDGSKPILSKGRIGLSK PIINTYSNALNESNLPAHLDQKKITPVWTKFGLLRVSVSYRRDWKFEINNTNDELFSA RHASVSHNSQGPQNQPEQEGQSDQDIGKRQPQFQQQQQPQQQQQQQQQQQRQHQVQTQ QQRQIPDRRSLSLSPCTRANSFEPQSWQKKVYPISRPVQPFKVGSIGSQSASRNPSNS SFFNQPPVHRPSMSSNYGPQMNIEGTSVGSTSKYSSSFGNIRRHSSVKTTENAEKVSK AVKSPLQPQESQEDLMDFVKLLEEKPDLTIKKTSGNNPPNINISDSLIRYQNLKPSND LLSEDLSVSLSMDPNHTYHRGRSDSHSPLPSISPSMHYGSLNSRMSQGANASHLIARG GGNSSTSALNSRRNSLDKSSNKQGMSGLPPIFGGESTSYHHDNKIQKYNQLGVEEDDD DENDRLLNQMGNSATKFKSSISPRSIDSISSSFIKSRIPIRQPYHYSQPTTAPFQAQA KFHKPANKLIDNGNRSNSNNNNHNGNDAVGVMHNDEDDQDDDLVFFMSDMNLSKEG" gene complement(909733..911022) /gene="PZF1" /locus_tag="YPR186C" /gene_synonym="TFC2" mRNA complement(909733..911022) /gene="PZF1" /locus_tag="YPR186C" /gene_synonym="TFC2" /product="Pzf1p" CDS complement(909733..911022) /gene="PZF1" /locus_tag="YPR186C" /gene_synonym="TFC2" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:2642897]" /experiment="EXISTENCE:direct assay:GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding [PMID:2642897]" /experiment="EXISTENCE:direct assay:GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity [PMID:8496187]" /experiment="EXISTENCE:direct assay:GO:0042791 5S class rRNA transcription by RNA polymerase III [PMID:2642897]" /experiment="EXISTENCE:mutant phenotype:GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity [PMID:8496187]" /note="Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA" /codon_start=1 /product="Pzf1p" /protein_id="DAA11602.1" /db_xref="SGD:S000006390" /translation="MGGEVLNNEGMPLAELKQETIPISRSESSESLNSLTSTRSSSSN RPKTYFCDYDGCDKAFTRPSILTEHQLSVHQGLRAFQCDKCAKSFVKKSHLERHLYTH SDTKPFQCSYCGKGVTTRQQLKRHEVTHTKSFICPEEGCNLRFYKHPQLRAHILSVHL HKLTCPHCNKSFQRPYRLRNHISKHHDPEVENPYQCTFAGCCKEFRIWSQLQSHIKND HPKLKCPICSKPCVGENGLQMHMIIHDDSLVTKNWKCHICPDMSFSRKHDLLTHYGSI HTEEDIPLELKYKISDIQQLVQDHGVQLGNSKHSNEQDEEKISNRLRKRRKLTENNNV EFLQNEVDLEKRLESGENGLNLLLNTVGRKYRCFYNNCSRTFKTKEKYEKHIDKHKVH ELKLKILQEKEENKTLVDQNHKEPFIIQKETQSAGDK" gene 911257..911800 /gene="RPO26" /locus_tag="YPR187W" /gene_synonym="RPB6" mRNA join(911257..911276,911353..911800) /gene="RPO26" /locus_tag="YPR187W" /gene_synonym="RPB6" /product="DNA-directed RNA polymerase core subunit RPO26" CDS join(911257..911276,911353..911800) /gene="RPO26" /locus_tag="YPR187W" /gene_synonym="RPB6" /experiment="EXISTENCE:direct assay:GO:0001054 RNA polymerase I activity [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0001055 RNA polymerase II activity [PMID:8288647]" /experiment="EXISTENCE:direct assay:GO:0001056 RNA polymerase III activity [PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0003968 RNA-dependent RNA polymerase activity [PMID:18004386]" /experiment="EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:2183013|PMID:1331084|PMID:2186966]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:12697831]" /experiment="EXISTENCE:mutant phenotype:GO:0006383 transcription by RNA polymerase III [PMID:12697831]" /note="RNA polymerase subunit ABC23; common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit" /codon_start=1 /product="DNA-directed RNA polymerase core subunit RPO26" /protein_id="DAA11603.1" /db_xref="SGD:S000006391" /translation="MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDAN GKTIVTGGNGPEDFQQHEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQIS MNAPVFVDLEGETDPLRIAMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL" gene complement(911988..912479) /gene="MLC2" /locus_tag="YPR188C" mRNA complement(911988..912479) /gene="MLC2" /locus_tag="YPR188C" /product="Mlc2p" CDS complement(911988..912479) /gene="MLC2" /locus_tag="YPR188C" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:15210731]" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:15210731]" /experiment="EXISTENCE:genetic interaction:GO:1902404 mitotic actomyosin contractile ring contraction [PMID:19109423]" /experiment="EXISTENCE:mutant phenotype:GO:1902404 mitotic actomyosin contractile ring contraction [PMID:15210731]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:15210731]" /experiment="EXISTENCE:physical interaction:GO:0016460 myosin II complex [PMID:15210731]" /experiment="EXISTENCE:physical interaction:GO:0032038 myosin II heavy chain binding [PMID:15210731]" /note="Regulatory light chain for the type II myosin Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring" /codon_start=1 /product="Mlc2p" /protein_id="DAA11604.1" /db_xref="SGD:S000006392" /translation="MDHSESLTFNQLTQDYINKLKDAFQMLDEDEDGLISRGDLTKIY ATLGKTLTDEEWSKMVPDNDTSTAEVGEEGVSFPIFLSIMGKNLSQFPEREELEESLK AIGRGHDLNVPLNEVIDSLKEAGFENPEEEFAKLFKLFTTNQQATEERTFRGKLFLDS ITD" gene 912664..916962 /gene="SKI3" /locus_tag="YPR189W" /gene_synonym="SKI5" mRNA 912664..916962 /gene="SKI3" /locus_tag="YPR189W" /gene_synonym="SKI5" /product="SKI complex subunit tetratricopeptide repeat protein SKI3" CDS 912664..916962 /gene="SKI3" /locus_tag="YPR189W" /gene_synonym="SKI5" /experiment="EXISTENCE:direct assay:GO:0055087 Ski complex [PMID:18042677|PMID:10744028]" /experiment="EXISTENCE:genetic interaction:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:10611222|PMID:9482746]" /experiment="EXISTENCE:mutant phenotype:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429]" /experiment="EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:11910110|PMID:17660569]" /experiment="EXISTENCE:physical interaction:GO:0055087 Ski complex [PMID:18042677]" /note="Ski complex component and TPR protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; role in preventing L-A mycovirus pathogenesis; mutations in the human ortholog, TTC37, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome" /codon_start=1 /product="SKI complex subunit tetratricopeptide repeat protein SKI3" /protein_id="DAA11605.1" /db_xref="SGD:S000006393" /translation="MSDIKQLLKEAKQELTNRDYEETIEISEKVLKLDPDNYFAHIFL GKALSSLPASNNVSSNRNLERATNHYVSAAKLVPDNLLAWKGLFLLFRTTEVVPDILS YDEYFDLCGQYADALLKQEQSQVELINDIKLLKKTHPDCQKAFYQHLKPGSLMAETIG RHLSTPQDALLNLIKILSNIETTEIGKTLSQNRLKLKASDPDYQIKLNSFSWEIIKNS EIDQLYNQLVNILADDQKRSEIENQWLEYRIKVLKSMPLDVKKDFFTKVKEMVEDMVL VNHQSLLAWQKYFEWTDYEDLDNMDAPLIIKYFKKFPKDPLAMILYSWLSSKLSKYDI KSLESANKPPEGHKKTEKETDIKDVDETNEDEVKDRVEDEVKDRVEDEVKDQDEEAKE DEEEDLDDIEIGLLEEEVVTVLTENIVKCKNNILAHRILCQYYLLTKEYEAALPYIKN GISLIAYNIKDLGVHLPLTKREFSLDLATVYTYVDAPKDHNAALKLYDNILSGDFSNI QAKMGKGIIFIERKNWKDAMTLLTQVHEQSPNNLEVLSELSWSKAHMGYMDEALAGLD TVIKGIKGMDLRSIDFRALNLWRQAKVYIMKHASINDAKQENVKCAFKLLIQSIKILD TFAPGFSTLGDIYCHYYKDHLRAFKCYFKAFDLDAGDYTAAKYITETYASKPNWQAAS SIASRLIKGEKAKAELRSNNWPFRVVGIAHLEKQEESDSIEWFQSALRVDPNDVESWV GLGQAYHACGRIEASIKVFDKAIQLRPSHTFAQYFKAISLCDVGEYLESLDILEKVCQ EAATEESFQIGLVEVLMRCSLDLYSQGFLLKSVSIAKDTIERIKIIISELKCENQQVW IYLSQVLRLFIWIESKVDTLPVESLVSIFENSQFSGSEEIDSVDNIKIDTLLDSTTDD NVSIACKFLILASKYSVSDQKFTDIAGTVRASYWYNIGISELTAFITLKEPQYRDAAI FAFKKSIQLQSNTSETWIGLGIATMDINFRVSQHCFIKATALEPKATNTWFNLAMLGL KKKDTEFAQQVLNKLQSLAPQDSSPWLGMALILEEQGDIIGSSKLFAHSFILSNGRSK AAQFMYAKNVLENHINNGDDERDIETVEKLTTASIALEQFFKKSPDSQFALQCALLTL ERLHHYENANELANRLIGILEKKFEKTQDERELFNFAIIKGQFARIHLGLGNFELSIE NADLSQGIISESSDEKSMKTKISNHICLGLSYFFLNDFDQTLNQFQELLSISKDSKHL VVLIAKVLYDVGESDTKEIALQELTEYIATSGADLLVTLTIAAMSILDDKREDLSIIL EELKALPLSKQIIDKHKDAPYLIEEITKRLYRNDTGKQVWQRSAYFFPNNLKVWERLD KNIQRRIASNGQNKVTAEEMSKLYCESKNLRSIQRGMFLCPWNVTAVKALNECF" gene complement(917077..919041) /gene="RPC82" /locus_tag="YPR190C" /gene_synonym="RPC3" /gene_synonym="RPC80" mRNA complement(917077..919041) /gene="RPC82" /locus_tag="YPR190C" /gene_synonym="RPC3" /gene_synonym="RPC80" /product="DNA-directed RNA polymerase III subunit C82" CDS complement(917077..919041) /gene="RPC82" /locus_tag="YPR190C" /gene_synonym="RPC3" /gene_synonym="RPC80" /experiment="EXISTENCE:direct assay:GO:0001056 RNA polymerase III activity [PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:3905793|PMID:10611227]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:1406632]" /note="RNA polymerase III subunit C82" /codon_start=1 /product="DNA-directed RNA polymerase III subunit C82" /protein_id="DAA11606.1" /db_xref="SGD:S000006394" /translation="MDELLGEALSAENQTGESTVESEKLVTPEDVMTISSLEQRTLNP DLFLYKELVKAHLGERAASVIGMLVALGRLSVRELVEKIDGMDVDSVKTTLVSLTQLR CVKYLQETAISGKKTTYYYYNEEGIHILLYSGLIIDEIITQMRVNDEEEHKQLVAEIV QNVISLGSLTVEDYLSSVTSDSMKYTISSLFVQLCEMGYLIQISKLHYTPIEDLWQFL YEKHYKNIPRNSPLSDLKKRSQAKMNAKTDFAKIINKPNELSQILTVDPKTSLRIVKP TVSLTINLDRFMKGRRSKQLINLAKTRVGSVTAQVYKIALRLTEQKSPKIRDPLTQTG LLQDLEEAKSFQDEAELVEEKTPGLTFNAIDLARHLPAELDLRGSLLSRKPSDNKKRS GSNAAASLPSKKLKTEDGFVIPALPAAVSKSLQESGDTQEEDEEEEDLDADTEDPHSA SLINSHLKILASSNFPFLNETKPGVYYVPYSKLMPVLKSSVYEYVIASTLGPSAMRLS RCIRDNKLVSEKIINSTALMKEKDIRSTLASLIRYNSVEIQEVPRTADRSASRAVFLF RCKETHSYNFMRQNLEWNMANLLFKKEKLKQENSTLLKKANRDDVKGRENELLLPSEL NQLKMVNERELNVFARLSRLLSLWEVFQMA" gene 919381..920487 /gene="QCR2" /locus_tag="YPR191W" /gene_synonym="COR2" /gene_synonym="UCR2" mRNA 919381..920487 /gene="QCR2" /locus_tag="YPR191W" /gene_synonym="COR2" /gene_synonym="UCR2" /product="ubiquinol--cytochrome-c reductase subunit 2" CDS 919381..920487 /gene="QCR2" /locus_tag="YPR191W" /gene_synonym="COR2" /gene_synonym="UCR2" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:11502169|PMID:11914276|P MID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:3028797]" /experiment="EXISTENCE:direct assay:GO:0030061 mitochondrial crista [PMID:19019989]" /experiment="EXISTENCE:direct assay:GO:0045275 respiratory chain complex III [PMID:10873857]" /experiment="EXISTENCE:mutant phenotype:GO:0008121 ubiquinol-cytochrome-c reductase activity [PMID:3028797]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:3028797]" /note="Subunit 2 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme" /codon_start=1 /product="ubiquinol--cytochrome-c reductase subunit 2" /protein_id="DAA11607.1" /db_xref="SGD:S000006395" /translation="MLSAARLQFAQGSVRRLTVSARDAPTKISTLAVKVHGGSRYATK DGVAHLLNRFNFQNTNTRSALKLVRESELLGGTFKSTLDREYITLKATFLKDDLPYYV NALADVLYKTAFKPHELTESVLPAARYDYAVAEQCPVKSAEDQLYAITFRKGLGNPLL YDGVERVSLQDIKDFADKVYTKENLEVSGENVVEADLKRFVDESLLSTLPAGKSLVSK SEPKFFLGEENRVRFIGDSVAAIGIPVNKASLAQYEVLANYLTSALSELSGLISSAKL DKFTDGGLFTLFVRDQDSAVVSSNIKKIVADLKKGKDLSPAINYTKLKNAVQNESVSS PIELNFDAVKDFKLGKFNYVAVGDVSNLPYLDEL" gene 921860..922777 /gene="AQY1" /locus_tag="YPR192W" mRNA 921860..922777 /gene="AQY1" /locus_tag="YPR192W" /product="Aqy1p" CDS 921860..922777 /gene="AQY1" /locus_tag="YPR192W" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10092523]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:9765289]" /experiment="EXISTENCE:genetic interaction:GO:0015250 water channel activity [PMID:11158584]" /experiment="EXISTENCE:genetic interaction:GO:0055085 transmembrane transport [PMID:11158584]" /experiment="EXISTENCE:mutant phenotype:GO:0006833 water transport [PMID:9765289]" /experiment="EXISTENCE:mutant phenotype:GO:0015250 water channel activity [PMID:9765289]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:15583134]" /note="Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance" /codon_start=1 /product="Aqy1p" /protein_id="DAA11608.1" /db_xref="SGD:S000006396" /translation="MSSNDSNDTDKQHTRLDPTGVDDAYIPPEQPETKHHRFKISRDT LRDHFIAAVGEFCGTFMFLWCAYVICNVANHDVALVAAPDGSHPGQLIMIAIGFGFSV MFSIWCFAGVSGGALNPAMSLSLCLARAVSPTRCVVMWVSQIVAGMAAGGAASAMTPG EVLFANSLGLGCSRTRGLFLEMFGTAILCLTVLMTAVEKRETNFMAALPIGISLFIAH VALTAYTGTGVNPARSLGAAVAARYFPHYHWIYWIGTLLGSILAWSVWQLLQILDYTT YVTAEKAASTKEKAQKKGETSSSSAVAEV" gene complement(922909..923379) /gene="HPA2" /locus_tag="YPR193C" /gene_synonym="KAT10" mRNA complement(922909..923379) /gene="HPA2" /locus_tag="YPR193C" /gene_synonym="KAT10" /product="histone acetyltransferase" CDS complement(922909..923379) /gene="HPA2" /locus_tag="YPR193C" /gene_synonym="KAT10" /EC_number="2.3.1.48" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006473 protein acetylation [PMID:23775086]" /experiment="EXISTENCE:direct assay:GO:0008080 N-acetyltransferase activity [PMID:23775086]" /note="Tetrameric histone acetyltransferase; has similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity; also acetylates polyamines" /codon_start=1 /product="histone acetyltransferase" /protein_id="DAA11609.1" /db_xref="SGD:S000006397" /translation="MSNTSEDNITVRFVTENDKEGWQRLWKSYQDFYEVSFPDDLDDF NFGRFLDPNIKMWAAVAVESSSEKIIGMINFFNHMTTWDFKDKIYINDLYVDENSRVK GAGGKLIQFVYDEADKLGTPSVYWCTDESNHRAQLLYVKVGYKAPKILYKRKGY" gene complement(924304..926937) /gene="OPT2" /locus_tag="YPR194C" mRNA complement(924304..926937) /gene="OPT2" /locus_tag="YPR194C" /product="Opt2p" CDS complement(924304..926937) /gene="OPT2" /locus_tag="YPR194C" /experiment="EXISTENCE:direct assay:GO:0000138 Golgi trans cisterna [PMID:25359886]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:25130273]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:25359886]" /experiment="EXISTENCE:direct assay:GO:0006857 oligopeptide transport [PMID:9643541]" /experiment="EXISTENCE:direct assay:GO:0035673 oligopeptide transmembrane transporter activity [PMID:9643541]" /experiment="EXISTENCE:genetic interaction:GO:0044088 regulation of vacuole organization [PMID:25359886]" /experiment="EXISTENCE:genetic interaction:GO:0061091 regulation of phospholipid translocation [PMID:25359886]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:19767828]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:25130273]" /experiment="EXISTENCE:mutant phenotype:GO:0051515 positive regulation of monopolar cell growth [PMID:25359886]" /note="Oligopeptide transporter; localized to peroxisomes and affects glutathione redox homeostasis; also localizes to the plasma membrane (PM) and to the late Golgi, and has a role in maintenance of lipid asymmetry between the inner and outer leaflets of the PM; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles and in polarized cell growth" /codon_start=1 /product="Opt2p" /protein_id="DAA11610.1" /db_xref="SGD:S000006398" /translation="MSETVKDKVIIDEKVSTKGTVDYAEGAEYSERLSNHSSDFSQWY TDEQILHFMKKLGYENRTLYDIPEDVAYILKKMPELTLEDSFKILKDSIIYFKDDENI PHDQYEEWKRLVDLEDLDSKEGIDEYDSFDIRAFASAIKFHSPYQEVRAVVDPEDDPT IPVETFRAYFLAIIWSVIGSGFNEFFSHRVVSISLNTPIIQMFLYICGKAWAKTIPCW TITIRGRKYGINIDKPWTQKEQMFSTLLYAICQGAFYTHYNILTQKLFYHSAFSFGYQ FLLSLSVQFIGFGFAGILRKFVVYPARALWPTVMPTIAINKALLGKEKHESGMSRYKF FFLTFFIMFIYNWFPTYIINILNTFNWMTWIKPSNINLANITGGVTGLGINPISSFDW NVISFNSPLVYPFWSYLTQYLGCILAALIVIAVYYSNYMSCQYLPIFTNSLYTNTGHS FKVTEVLDSDNKLDVKKYQSYSPPYYSAGNLVSYGAFICAYPLMITWSFIVHSKLLFN AFKDWALNLWAMRKLKSWVTMFKSDYRALDDYDDPHSNAMKNYKEVPDWWYFAILIGS LVVGIAVVEHYPTNTPVWGLFVCLGFNFVFLIPTTILQATTGYSFGLNLLIEMVMGYA LPGNPIAIMILKAFGYNIDGQADNYVSNLKIAHYCKIPPMALFRGQCVIVFIQIFVNL GVLNWQISNIKDFCTPHQNAKFTCPDAVTYYNASVVWGAIGPKRIFNYIYPIFKWCWL IGACIGIFFGVWKRWGKFYPRYFDPMLFVGGMLNMSPPYNLMYYTSGMIVSYISQYYM KRHHLNLWEKYNYVLSAGFSTGLVLSAIIIFFAVQYKDTAFNWWGNTVPYAGADGVGY PLKNITDTANGYFGYAPGHYP" gene complement(927965..928294) /locus_tag="YPR195C" mRNA complement(927965..928294) /locus_tag="YPR195C" /product="hypothetical protein" CDS complement(927965..928294) /locus_tag="YPR195C" /note="hypothetical protein; conserved across S. cerevisiae strains" /codon_start=1 /product="hypothetical protein" /protein_id="DAA80347.1" /db_xref="SGD:S000006399" /translation="MNSLIPLLVEASTYIVRGESSISIAIGIGPQASRSVPYHILCRG CDGTVTTFRTWHTQPLGPCNTIIIGRKGNETTGGAEQRRQQHLTSDSATKASLVGFCG LYYYFRK" gene 931376..932788 /locus_tag="YPR196W" mRNA 931376..932788 /locus_tag="YPR196W" /product="putative maltose-responsive transcription factor" CDS 931376..932788 /locus_tag="YPR196W" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /note="Putative maltose-responsive transcription factor" /codon_start=1 /product="putative maltose-responsive transcription factor" /protein_id="DAA11611.1" /db_xref="SGD:S000006400" /translation="MSIVRQSCDCCRVRRVKCDRNRPCDRCRQRNLRCTYLQPLRKRG PKSIGESNLERAAEIQMVTVNNNIMAAPVMYKKVPKKVIDQCLRLYHDQLYVIWPMLS YDDLYKLLEENYEDCSTYWFLVSLSAATLSDLHTKIEYKKGFFFAGEQLCNLCMSSRR FFDDLSNSDIFRIMTYYCLHRCYAQFADTRTSYRLSCEAIGLIKIAGFHREETYEFLP FGEQQLIRKVYYLLLMTERYYAVYIKCVTSLDTTISPPQPEIVTDSRLSLDSFLEVIK VFTVPGKYFYDALATNSVNGSYTEDSLKRIWNELHISSLDIEPYSYGYIDYLFSRHWV RTLAWKLVLNKKDMRMNFFSNTNATHIPVEIAKDMLQDTLLTPIDLYDVHGPVIPMKA LEIANALVDVVSKYDHNMKLEAWNILCDVSKFVFSLKHCNHKMFQRFSTKCQSALIDL PISRPLRLNDDSKDEVDIIP" rep_origin 932983..933229 /note="ARS1631; Autonomously Replicating Sequence" /db_xref="SGD:S000118426" repeat_region 933071..933404 /note="Ty4 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007219" gene 934034..935665 /gene="SGE1" /locus_tag="YPR198W" /gene_synonym="NOR1" mRNA 934034..935665 /gene="SGE1" /locus_tag="YPR198W" /gene_synonym="NOR1" /product="Sge1p" CDS 934034..935665 /gene="SGE1" /locus_tag="YPR198W" /gene_synonym="NOR1" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:9483795]" /experiment="EXISTENCE:mutant phenotype:GO:0042910 xenobiotic transmembrane transporter activity [PMID:9483795]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:9483795]" /note="Plasma membrane multidrug transporter; member of the major facilitator superfamily; acts as an extrusion permease; partial multicopy suppressor of gal11 mutations" /codon_start=1 /product="Sge1p" /protein_id="DAA11612.1" /db_xref="SGD:S000006402" /translation="MKSTLSLTLCVISLLLTLFLAALDIVIVVTLYDTIGIKFHDFGN IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISG RVVAGFGGSGIESLAFVVGTSIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLS WRWCFYINLPIGAFAFIILAFCNTSGEPHQKMWLPSKIKKIMNYDYGELLKASFWKNT FEVLVFKLDMVGIILSSAGFTLLMLGLSFGGNNFPWNSGIIICFFTVGPILLLLFCAY DFHFLSLSGLHYDNKRIKPLLTWNIASNCGIFTSSITGFLSCFAYELQSAYLVQLYQL VFKKKPTLASIHLWELSIPAMIATMAIAYLNSKYGIIKPAIVFGVLCGIVGSGLFTLI NGELSQSIGYSILPGIAFGSIFQATLLSSQVQITSDDPDFQNKFIEVTAFNSFAKSLG FAFGGNMGAMIFTASLKNQMRSSQLNIPQFTSVETLLAYSTEHYDGPQSSLSKFINTA IHDVFYCALGCYALSFFFGIFTSSKKTTISAKKQQ" gene complement(938148..939032) /gene="ARR1" /locus_tag="YPR199C" /gene_synonym="ACR1" /gene_synonym="YAP8" mRNA complement(938148..939032) /gene="ARR1" /locus_tag="YPR199C" /gene_synonym="ACR1" /gene_synonym="YAP8" /product="Arr1p" CDS complement(938148..939032) /gene="ARR1" /locus_tag="YPR199C" /gene_synonym="ACR1" /gene_synonym="YAP8" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:18593383]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:18593383]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:24358276]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14978214|PMID:15147884]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15147884]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:14978214|PMID:11527213]" /experiment="EXISTENCE:genetic interaction:GO:0071243 cellular response to arsenic-containing substance [PMID:11527213|PMID:14978214]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:18593383]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:18593383|PMID:15575969|PMID:14978214|PMID:15147884|P MID:11527213]" /experiment="EXISTENCE:mutant phenotype:GO:0071243 cellular response to arsenic-containing substance [PMID:15147884|PMID:18593383|PMID:11527213|PMID:15575969]" /note="Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8" /codon_start=1 /product="Arr1p" /protein_id="DAA11613.1" /db_xref="SGD:S000006403" /translation="MAKPRGRKGGRKPSLTPPKNKRAAQLRASQNAFRKRKLERLEEL EKKEAQLTVTNDQIHILKKENELLHFMLRSLLTERNMPSDERNISKACCEEKPPTCNT LDGSVVLSSTYNSLEIQQCYVFFKQLLSVCVGKNCTVPSPLNSFDRSFYPIGCTNLSN DIPGYSFLNDAMSEIHTFGDFNGELDSTFLEFSGTEIKEPNNFITENTNAIETAAASM VIRQGFHPRQYYTVDAFGGDVLLSAMDIWSFMKVHPKVNTFDLEILGTELKKSATCSN FDILISLKHFIKVFSSKL" gene complement(939279..939671) /gene="ARR2" /locus_tag="YPR200C" /gene_synonym="ACR2" mRNA complement(939279..939671) /gene="ARR2" /locus_tag="YPR200C" /gene_synonym="ACR2" /product="Arr2p" CDS complement(939279..939671) /gene="ARR2" /locus_tag="YPR200C" /gene_synonym="ACR2" /experiment="EXISTENCE:direct assay:GO:0030611 arsenate reductase activity [PMID:10801893]" /experiment="EXISTENCE:mutant phenotype:GO:0030611 arsenate reductase activity [PMID:10801893]" /note="Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p" /codon_start=1 /product="Arr2p" /protein_id="DAA11614.1" /db_xref="SGD:S000006404" /translation="MVSFITSRQLKGLIENQRKDFQVVDLRREDFARDHITNAWHVPV TAQITEKQLNQLIKGLSDTFSSSQFVKVIFHCTGSKNRGPKVAAKFETYLQEEDITSK FESCILVGGFYAWETHCRESNLKLIVSG" gene 939922..941136 /gene="ARR3" /locus_tag="YPR201W" /gene_synonym="ACR3" mRNA 939922..941136 /gene="ARR3" /locus_tag="YPR201W" /gene_synonym="ACR3" /product="Arr3p" CDS 939922..941136 /gene="ARR3" /locus_tag="YPR201W" /gene_synonym="ACR3" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:20655873]" /experiment="EXISTENCE:direct assay:GO:0015105 arsenite transmembrane transporter activity [PMID:24291645]" /experiment="EXISTENCE:mutant phenotype:GO:0015104 antimonite transmembrane transporter activity [PMID:20655873]" /experiment="EXISTENCE:mutant phenotype:GO:0015105 arsenite transmembrane transporter activity [PMID:24291645]" /experiment="EXISTENCE:mutant phenotype:GO:0015297 antiporter activity [PMID:21447319]" /experiment="EXISTENCE:mutant phenotype:GO:0015699 antimonite transmembrane transport [PMID:20655873]" /experiment="EXISTENCE:mutant phenotype:GO:0015700 arsenite transport [PMID:24291645]" /note="Plasma membrane metalloid/H+ antiporter; member of bile/arsenite/riboflavin transporter (BART) superfamily; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite; protein displays 10 transmembrane segments with cytoplasmically oriented N- and C-terminal domains" /codon_start=1 /product="Arr3p" /protein_id="DAA11615.1" /db_xref="SGD:S000006405" /translation="MSEDQKSENSVPSKVNMVNRTDILTTIKSLSWLDLMLPFTIILS IIIAVIISVYVPSSRHTFDAEGHPNLMGVSIPLTVGMIVMMIPPICKVSWESIHKYFY RSYIRKQLALSLFLNWVIGPLLMTALAWMALFDYKEYRQGIIMIGVARCIAMVLIWNQ IAGGDNDLCVVLVITNSLLQMVLYAPLQIFYCYVISHDHLNTSNRVLFEEVAKSVGVF LGIPLGIGIIIRLGSLTIAGKSNYEKYILRFISPWAMIGFHYTLFVIFISRGYQFIHE IGSAILCFVPLVLYFFIAWFLTFALMRYLSISRSDTQRECSCDQELLLKRVWGRKSCE ASFSITMTQCFTMASNNFELSLAIAISLYGNNSKQAIAATFGPLLEVPILLILAIVAR ILKPYYIWNNRN" rep_origin 942084..943032 /note="ARS1632; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay" /db_xref="SGD:S000130202" telomere 942396..948010 /note="TEL16R; Telomeric region on the right arm of Chromosome XVI; annotated components include an X element core sequence and a short Y' element; TEL16R does have telomeric repeats (TEL16R-TR), but they are missing from the genome annotation due to difficulties encountered during sequencing and/or assembly" /db_xref="SGD:S000029002" gene 943032..943896 /locus_tag="YPR202W" mRNA join(943032..943050,943199..943896) /locus_tag="YPR202W" /product="hypothetical protein" CDS join(943032..943050,943199..943896) /locus_tag="YPR202W" /note="hypothetical protein; similar to telomere-encoded helicases; down-regulated at low calcium levels; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11616.1" /db_xref="SGD:S000006406" /translation="MEIENEQICTCIAQILHLLNSLIITFSDDDKTETGQSFVYIDGF LVKKHNNQHTIVNFETYKNKMKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFES IPTEVRSFYEDEKSGLIKVVKFRTGAMDRKRSFEKIVISVMVGKNVQKFLTFVEDEPD FQGGPIPSKYLIPKKINLMVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFPCPG TLSRNSECQAERQLYDAYFH" gene 943880..944188 /locus_tag="YPR203W" mRNA 943880..944188 /locus_tag="YPR203W" /product="hypothetical protein" CDS 943880..944188 /locus_tag="YPR203W" /codon_start=1 /product="hypothetical protein" /protein_id="DAA11617.1" /db_xref="SGD:S000006407" /translation="MRTFTDFVSGAPIVRSLQKSTIRKYGYNLAPHMFLLLHVDELSI FSAYQASLPGEKKVDTERLKRDLCPRKPIEIKYFSQICNDMMNKKDRLGDVLHVCCPS " gene 944603..947701 /locus_tag="YPR204W" mRNA 944603..947701 /locus_tag="YPR204W" /product="Y' element ATP-dependent helicase" CDS 944603..947701 /locus_tag="YPR204W" /EC_number="3.6.4.12" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:9837911]" /experiment="EXISTENCE:direct assay:GO:0032508 DNA duplex unwinding [PMID:9837911]" /note="DNA helicase encoded within the telomeric Y' element; Y' -helicase protein 1" /codon_start=1 /product="Y' element ATP-dependent helicase" /protein_id="DAA11618.1" /db_xref="SGD:S000006408" /translation="MADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPY TVLLANCMIRLGRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWEN IVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEA VADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHK IWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKL GAAEKVSRTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRL RDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGS RTDLSADTVELIERMDRLAEKQATASMSIVALPSSFQESNSSDRCRKYCSSDEDSNTC IHGSANASTNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTT ASTNVRTSATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTNSSTNAT TTASINVRTSATTTESTNSNTNATTTESTNSSTNATTTEGTNSNTSATTTASTNSSTN ATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPN TSENMNVLQFLGFRSDEIKHLFLYGIDVYFCPEGVFTQYGLCKGCQKMFELCVCWAGQ KVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKYFSVKRGEIYSQIQR NYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQY FLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQ LRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFCNKTFRQKLEYLLEQISE VWLLPHWLDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDILLCRDSSREV GE" BASE COUNT 293950 a 180367 c 180509 g 293240 t ORIGIN 1 aaatagccct catgtacgtc tcctccaagc cctgttgtct cttacccgga tgttcaacca 61 aaagctactt actaccttta ttttatgttt actttttata gattgtcttt ttatcctact 121 ctttcccact tgtctctcgc tactgccgtg caacaaacac taaatcaaaa cagtgaaata 181 ctactacatc aaaacgcata ttccctagaa aaaaaaattt cttacaatat actatactac 241 acaatacata atcactgact ttcgtaacaa caatttcctt cactctccaa cttctctgct 301 cgaatctcta cataataata tatcaaatct accgtctgga acatcatcgc tatccagctc 361 tttgtgaacc gctaccatca gcatgtacag cggtaccctc gtgttatctg cagcgagaac 421 ttcaacgttt gccaaatcaa gccaatgtgg taacaaccac acctccgaaa tctgctccaa 481 aagatattcc agtttctgcc gaaatgtttt attgcagaac agccctatca gcatcgacag 541 gaatgccgtc caatgcggca ctttagatgg ggtaactccc agcgcaagct gatctcgcaa 601 gtgcattcct agacttaatt catatctgct cctcaactgt cgatgatgcc tgctaaactg 661 cagcttgacg tactgcggac cctgcagtcc agcgctcgtc atggaacgca aacgctgaaa 721 aactccaact ttctcgagcg cttccacaaa gaccgtatcg tcttttgcct cccattcttc 781 ccggcacttt ttttcgtccc agttcaaaaa gtactgcagc acctctgtct tcgattcacg 841 caagttgctc catactttat aatacaactc tttgatctgc cttccagaca tgcggaaaac 901 ttggctccct tgcttgcctc ttgtcgaatc caatacacta attgtttctc ttcttctagt 961 aatggccagg taccaagcat aatttctctg tatctgagag tagatctctc ccctttttac 1021 gctaaaatat ttcaaatatc ctacagggtc cccatgatat ggctcgatgt cttccaagta 1081 ttctttgtat tcctcgtcat ttcgcagcat tctctccaca gctagtgctt cccaagccat 1141 cctccgatac gatactttct ggccagccca acagacacag agctcgaaca tcttttgaca 1201 gcccttgcat aatccgtatt gtgtgaatac tccctctggg cagaagtata cgtcaatacc 1261 atagaggaaa agatgtttaa tttcgtcaga ccgaaatcca agaaactgta agacattcat 1321 attctcggaa gtattgggaa attgtgcttt cagtttcttt ctctctagca aaaccatttg 1381 actccctttc cgcttatacg actctttgtt aatgtcggtg actggatgga atctattatc 1441 ctcagcattg ccatctttat tggcgtcctc cttggcacta gcgttggtac tttcagtggt 1501 agtggcatta gtgctggagt tggtgctagc agtggtagtg gcattagtgc tggagttggt 1561 gctagcagtg gtagtagcac tagtgttgga gtcggtactt tcggtggtag tagcactagt 1621 gttggagtcg gtactttcgg tggtagtagc actagtgttg gagttggtac tttcagtggt 1681 agtcgcacta gtcctgacgt tgatgctggc agtggtagta gcactagtcc tgacgttggt 1741 gctggcagtg gtagtagcat tagtgctgga gttggtactt tcagtggtag tcgcactagt 1801 cctgacgttg atgctggcag tggtagtagc actagtcctg acgttggtgc tggcagtggt 1861 agtagcatta gtgctggagt tggtagtcgc attggtactg gcattagcac taccatgaat 1921 gcacgtgtcg ctgtcctcat cactgctgca atactttctg cacctgtcac tgctattgct 1981 ctcctggaag ctagacggta acgcaacgat cgacatggaa gctgtcgcct gtttttcagc 2041 caatctgtcc attctttcta tcagttccac tgtgtcagca gacaggtctg tcctggagcc 2101 acagcatcca acatgctggc ccttttttcc tttctttgat tcaagtccat agaactcgcg 2161 tacctgttcg gttatacagc cttccttaat cggtggtaat tcacccttac gattccttgc 2221 cgcccaactg ttttttctag ataatagata acagaggccc ccatctctta gtctccctac 2281 gccttgaatg agctcaataa tattaagtct attatcaagc atgatcacca tcatcaattg 2341 cttaatgtca attccttcag tcactaattt cgttccgatg agaactcgca tgctaccgtc 2401 agtgacaaac tcctttgtgc gagacacctt ttctgcagca cccagcttcc cgtgtatcca 2461 taccacccta aaatactttc tccaagagca ggccaattct tccacttcgt tggttgtgct 2521 tgcaactaca atggccttcg actctggttc aatttcaaag agggctaaaa gaagcttcag 2581 tgcttcttcg ggctgtgatt ccactttctt ccaaatttta tgaacatgcc ctaaaggcac 2641 ctcggatttc tccttgatta gattaaacat ccgtgttgga tagctggata gacctctgct 2701 gagatcttcc gaccgtttga gctcgttgat gtccatcgac ttcttggcca gtcccgtaag 2761 cccaatacgc tgcaacgcag catcagctac agcctcaggt gctgtgccgc tcaaaaagat 2821 tgctttctca aaagcgtcaa aatcaaggtt agttatgccc ccaaattgcg actgccggta 2881 gacctccgtt tcaaagttgt gaaactcatc tacaatgagg taacccaatt ttacgttgtt 2941 ggtcctaaag gtgcactcaa caatattctc ccacgcagct atcctgtctg tgaaattagt 3001 gctagcaaga tcatcgtaga tccccacgta taaatcagta acgccatcgc aaccttcttc 3061 aataaagttt cttacagggg ccacattcaa gcaaccgcat cggctcaacc tgatcatgca 3121 attagcaagc aacactgtgt acggtacaaa cagaaacgac acatatttca cgtcgccctt 3181 agacgccagt gctatcaagg ggagatgaaa taactccgtc ttaccatagc ccggtggggc 3241 ctgtactgcc acagagggtg tgtctgccat gtatatttca tgacataagc gcaactgatg 3301 caagtccctg aattcaaagg agctgccaaa gagtttctgg cctgcgacga ggatatcgtt 3361 tgtactcttg ggctctcggg gcctttttcg cgttactctt gaaatttttt gatgatgatc 3421 tgaactcgcc gcctcacctg ccactacgtc ttccgcattc cgagtactag agaatgaaca 3481 atggtagtcg ctttcaaggc ctaaccattg aatccagcgc tcggaagctc gttcctgcaa 3541 taaagtggcg gtcgtcccac tgacactagt taacgaaaag gaatccacac cgtaaatatt 3601 tcgccctgtt tgaacggaat gattggccat gagttcactc gtcgccgact cgtacaaatc 3661 tgtttcaaat ctgctaccta cgcagtgccg tcctagggca atcaacccct gacgcatctc 3721 ccgaaaattc agcttctgag gtgcattctt cggaagttcc ctcatgtact gccgaaaagt 3781 tgcgtattca accagacagc ccttcgcggt attcagaaac atgtaggaat acaaaactat 3841 cctcgaaatg tctcgatttg ttacttgatc tggatcctca aatcccacca catccatcca 3901 aggatcatga ttaaaagcgt cataactgtt accaagcgca catatttgca tttgccttag 3961 cacagtgaca aaataaaaca cgtaatctga agtgagtccg tcaagcgtct taagtcgagg 4021 ctccgatgaa ccgttcttgt tgtaatcagt gtacagttgg atgcgtcttg ttgtatcatc 4081 gacgtatacg ttgcgctgag gaccggcaaa agcgagtagc tgaagctctg gataacggta 4141 agggtatcct acggcaaaat ggatcatcca cataagtggc accgtaagct cgtcaattgc 4201 aacagtgact ttatttttaa gagccgcggt cattttgtta gtatctcttc tcaacttggg 4261 cagcacaatt tcacgatatt taacaggtat catttgaagg aaagaatcgt tctccagata 4321 ctcgtcaatt cctcgctttg gctctctgaa caaaacttct cgattacgca aaatgaggct 4381 ggcaatatca accactgtag gcatataaaa gcagtcgttc aattcttccc aaaggttatc 4441 aaactgagcc ttgcatgcaa agtaaaagcc gcggacatac tcgcgattaa acagttttcc 4501 acatactgat acaccatcag aagaaggtac caaagttatt ctataagagt ccttcagcgc 4561 ggtttcctgc gctacttcgt ggtacagaat tttgatccat ttccacatcg caacgccgtt 4621 gttgtcatca aatatatcta aatcccttgc ggtacaagca caagacgaca ccaataaagc 4681 tttcacggca tctagtgttt ttctgagtct tcgtggagtg ttaggactgc gcaacttaca 4741 tactttcaag ccatgctcgt ccacagaggg aataatgggt tcttcattcg taatggatcg 4801 atcctcttcg tcaccagcgc caccacgggg acccgccccg aaattgagcg cacatgctcg 4861 caagataata tgcaaaatat cacccaatcg gtcctttttg ttcatcatat cgttacatat 4921 ctgtgaaaag tactttatct cagtgggttt acgtgggcat agatcacgct tcagccgctc 4981 tgtgtcgact ttcttttcgc caggtaaact tgcttggtat gcagaaaaaa tcgatagctc 5041 atctacgtgt agtaacaaaa acatgtaggg tgccaaattg tatccatatt tccttatggt 5101 gcttttctga agacccctta caataggtgt gccagaaaca aagtcagtga aagtacgcat 5161 cgtagagctg tcgttcggcc tggcactcgc tatttcgtaa caacgttcca ggacacggaa 5221 actcaactca ttatagtatc ctctgttgag gtaaaaaaga gaaagggtat cgtaatcctt 5281 tctattgaat ttcaaagtat gcacttgaaa caacgtgtag accatcaagt tgattttctt 5341 gggaataaga tactttgaag ggattggtcc gccctggaaa tctggttcgt cttcaacaaa 5401 cgtcaggaac ttttgtacat ttttcccgac catgacggaa acgacaattt tttcaaaaga 5461 ccttttccta tccattgcac cagttctgaa ttttaccact ttgattagac cagacttttc 5521 gtcttcgtag aatgaccgca cttccgtggg gatcgattca aataaagtta ttgagggaca 5581 atgtaccaag tcgtttttgt tatttagagc cgactcaaac tcgtcaaagt ttgctttttc 5641 aaacttacgc ctatcggaaa ctttcatttt atttttgtaa gtttcgaaat taacaatagt 5701 atgttgattg ttatgctttt tgacaagaaa tccatcaata taaacaaaag attgtccagt 5761 ttccgtctta tcatcatcta agaatgtaat aattaagcta ttgagaagat gcagaatctg 5821 cgctatgcag gtgcaaatct ctagcagcag caaagtaaat tcagttagta agaaatctca 5881 ctaagataag cgactgtctg tccccttcaa gcacaacata gaaagcagaa ggatgtctca 5941 ttcatcgctt gatttccggc ctgcaaaaat aaagtagtcg gtacgtacgt tcgttttcaa 6001 tttccatggt gcacagtatc ttaactatct gcttagtcga ggagaaccag gattctgttc 6061 gttgctcagc cgcttcgtgg atattctctt ggatacttta aatatggacc tacgcttagc 6121 ctgcgcttag cctacaactt cttccgctct cgaaaagacc aatataatag aaagttataa 6181 attacatttc cttattaggt atacgacctc gcgcttcgaa gtagaggagc cctttttggc 6241 gtacctacat atggcgcgtc agacagacaa acttccccca aaaatgtatt accccgccga 6301 ataagaaaac agacccattc acccacgacg tatcaagtta cttccttggt gcaatgtccc 6361 actataaaaa aattccttga cgctagatcg ttggactaaa atctgcgtca caatcgccta 6421 aacaggaaat attgcctatt ttcgtacaag gttacttcct agatgctata tgtccctacg 6481 gccttgtcta acaccatcca gcatgcaata cagtgacata tatatgatga acctgtctct 6541 caacttaccc tccattaccc tacctctcca ctcgttaccc tgtctcactc aaccatacca 6601 ctcccaacca ccatccatct ctctacttac tactaccatc caccgcccat cataaccgtt 6661 accctccaat tacccatatc caactccacc accacttacc ctactattac cctaccatcc 6721 atcatccgct actcaccata ctgttgttct acccaccatg ttgaaacgtt aacaaatgat 6781 cgtaaataat acacatatac ttaccctacc accacatgcc gtatccaccc tcacttgtat 6841 actgatatgg catacgcaca cggatgctac agtatatatc atctcaagtt accctactct 6901 cacattccac tccatggccc atctctcact tcatcagtac taaatgcact cacatcatta 6961 ttaacggcac ttgcctcagc ggtctatacc ctgtgccatt tacgcataac tcccacgatt 7021 atccacattt taatatctat atctcattcg gcggccccaa atattgtata actgctctta 7081 atacatacgt tataccactt ttacaccgta tactaaccac ttaatttata tacacttatg 7141 ttaatataac caaaaaatca ccatcaaaat cacctaaaca taaaaatatt ccattcttca 7201 acaataatac ataaacatat tgacttgaag tacgagcact accatgacgt cattaacgta 7261 aaagttcctt aatattccca tttgcttgaa cggatgccac ttcagaatat ttcgtactta 7321 cacagacttc acattagaat attatgtcat cccattgttg tgacactctt tattcaccga 7381 gcaataatac ggtagtggct cacacacatg tgggcgctat cccctcaact ctattccagt 7441 tacagttaca taaaaaacta acctaacaaa gaaataataa tatttatgtc acaaaaatca 7501 gggtctcttg ctatgacttg ctacttgttt tgccctgatc tgcaatctta tttttaaaag 7561 tgacgcatat tctataaacg accccgaggc gacgcgccaa aaaatgaaaa aaaggaagga 7621 cacattttta tagaaagaca aaaggctgcg aagccgcaca tttccaagtt cagtattgct 7681 tattggacat accctattag ctttattacc atgcaccctt ttccagaaca gtgacgcaaa 7741 agagaagttt ctattttggg tttattgtat tgagaaaata ctccacaaac actgttattg 7801 atcaaaaatg agttgtcata ttaatataca tttacatatg agaaattgta tttatatcaa 7861 tagaataaca tattttattt cattttcttt actttttaat gtctatggaa tttcgttcgt 7921 aaaagcttct ctctattttg gaatagcagt gtagataccg tccttagata gagcactgga 7981 gatagccggt ctcaatctgg tagagtacca tgggacacca gtgatgactc tggtgacttg 8041 ttcagctgga ataccagtca acatggtggt gaagtcacca tagttgaaaa cagcttcagc 8101 aatctcaact gggtaggtct ctgttggatg agctgcttga aacaagtagt attgagccaa 8161 atgagctctg atatcggaga cgtaaacacc caattcgacc aagttgactc tttcgtcaga 8221 tggagataga gtggtagtgg ctggagcagc ggcaacaccg gcagcgatag cggcaacacc 8281 agcagcgatt gaagttaatt tgaccattgt atttgttttg tttgttagtg ctgatataag 8341 cttaacagga aagaaatgaa taaagacata ttctcgaagg catatagttg aagtatctct 8401 atttatacct attccttcat tggtcatcac cacttaaacg attcgttaac agatgctcct 8461 ttagcacttc acatattctc catatctcat ctttcccaca acttcatgat cactatgaag 8521 atgtttttgt ttttaaacga ggcatgcatc tttatagatt ctgtatgcga aggtattgtt 8581 ttctggggcc tttgtctatt cgtatgcgcc gaatgtgaga atgccagtta taggggtgcc 8641 gaggtgcctt ataaaaccct tttccgtgcc tgtgatactt ccttttttgg tatagcagaa 8701 tgtctgaatt tagttgctat agatcctcgt tcagaagcgt attgctaagc ctatctccag 8761 tataccctaa acgatcgccg agaaaaaata atactgtacc ctcctatttc ccggaattgt 8821 acagaatagt aggtatgtgc tgggagtcgt atattgttag agtctgtaat ttttacgcgc 8881 gcctagtgga ttcgttgata cgattacgtt attctaaacc gtcgcaaagc aaattgtgtt 8941 gaagtaattc aagactttaa atcacttgta ccaaaatcat tgttgcgaaa acttatcctc 9001 agtattagtt tcttgaccgt aacagtagtt gaaaaaaata aaatcatttc tatgatcgat 9061 acactttcat tatttaactt ctctattatg gtgtaacttc ttacttttgt cagaaaaaaa 9121 gatttcaaga cacaacaaga atggggtcaa aggtctgctt gtactatcag gaagatttga 9181 taccaaccgc gttataaggg ttactagaaa gtaatagctg ctaaaaaatt taaaccgaag 9241 agattaatca gaaagctgaa aaactgcagt gttagtagag ttgtaagcat ttcttgattg 9301 gaacagcctt cccccacacg tccacccttg ttcagacaga ttcgtaatga ttttgtgtgt 9361 aggcaatgga aaactttaaa aacggtttga tttcctacaa gataaaacat atgaataaaa 9421 taacttgtgt caaatgcccc atttccatac tgtaacccaa atcaacgaaa taaaaaataa 9481 aacctcatat gatttacttt atttagtcat aaaaaaacaa aaaaaaaaaa aaaaaaaaag 9541 gaaacaagac aatcctttat agtttgtttc catcatgaaa cctatgacca gcatatatac 9601 aatcgtcccc cagttcctct tcgatacgca aaagttcatt atacttggcc agtctttctg 9661 atctcgacaa agcgcccgat ttaatttgac cacatcttaa accaacgacc aaatcagcga 9721 taaacggatc ttcggtttca cctgatctat gcgatatcat tacaccccat ccagcatcga 9781 aagcctgatt ggcggcttca atagactcag tcagagtacc gatctggttg agtttcagca 9841 acagagtatt cgcacatttc tcctctatag cacgggcgat cctggtcttg ttggtgcatg 9901 tcaggtcatc tgcaataatc tgaacattga cagtctttag gaaggcagac cacgaggacc 9961 aatcatcttc ggcgtaggga tcttccaggg aaatgattgg gtatttcttt agcaatgaat 10021 ggtaatattc tgctaactgg gctggactga gccagtgaga tgggtcagag ttcggttcct 10081 tgaaatttag gtcgtatttc ccgtccttat aaaaaacaga aggagcacta tcgattccta 10141 ctttcactct accctcgtaa ccgcatatgt taatggcttc cacaatcatg tccaaggcgt 10201 cttcggcagt gtcaatatcg ggggcaactc caccctcgtc accaacattt ccagcggaag 10261 gtccatattg ctccttcgcc aatatcttca aatgatggta aacttccgaa cccatcctca 10321 tggcttctgc aaagctctga gccccgactg gcgcgatctt gaattcttgc atagctaaag 10381 agccaccggc gtgggctcca ccattcaaaa cattgaaaaa aggaacagga ataacaaagg 10441 ggtcctgtct agcatccgct aactcggcta tatacttgta gagagtaatt cccttttgtg 10501 cggcagcagc tcgagcaacg cacaaggaaa caccaaggat agcattggcg cccaaccttg 10561 acttgttaga agttccgtct aacgatatca tgagctcgtc tatgcccttc tgattggtta 10621 cacataattc ggacttgatt aaagcaggcc ctatgatact attgacgtta ctgactgcct 10681 tggtcacccc ttttcccatc cattcggact tgttcccgtc tctaagttca acagcttcgt 10741 gaatgccggt ggaggcacca gatgggacga tcgctctgaa gagaccattc tctgttgtaa 10801 tttcaacctc aacagtcgga ttgccgcgag aatcatacac cgttctagca tgtaccttcg 10861 tgatggacat atttttatcg ttgagattcg attttttcct caccttgttt tggtatttct 10921 attgcaagac aaagtgaaag aagaagaagt ggtggtaaaa aataactata tataatgaaa 10981 attgtaacct ggtgggagtg caaactgtaa gtgataacct gccagatcca tgtttctatt 11041 atatacctaa gaaccagcca agttaggtaa acgaggagtc tttcaatatc tcttttctag 11101 tgagaatgtt atttaggtaa atgaacaagt taccactata ctactcaccc cctacacttt 11161 gtttgtgacc tctcccctta tccagttcat cgaaactttt ttttcaactt gtggcgatct 11221 gtgacattgt ctactacaag aaccgatttt ggttgatgtc tgtaaaaaaa acaaccttac 11281 ctttccagat ccaactttcc aggagagctg cgtgagtttc aaatatttac catgtcggag 11341 aaagctccca agtacttcct tgttcttgtc attttttcct tatctccatc ctttaaggaa 11401 ggtatttcca ttatgcgatt ctataaatcc gagcatgcga gtatttcttt tcttggcgcg 11461 gagtcgctga tgacgcaata ggcacattca cgaacatcca ggactggtaa tcttctcgtc 11521 ttaaagaaaa tccaaccacc agtaagaaac tcttgggtaa aatggggtat ctgaaatatt 11581 gcatagctgc aaatgaagat attcagtatc agcataggta ttttcatgaa ggataggtaa 11641 aaagaaagaa aagaaaaata tctttttgac tgttgttctt gcaattatca caattagggg 11701 actttaaaac cgatacttga tatatgagca cagtcaaggg gccggttctt gagattttaa 11761 tggaaaagag gaaagttgca catacaggtc tgcttttctt tgcttgctcc agacaacgat 11821 acttagaact aaaacatatt tctagaacac ttttctcctt cattcaaaaa gaaaactggc 11881 cttgcaatga ctccaaaaag agcgctaata tctcttactt cataccacgg tcccttctat 11941 aaagatggtg cgaaaacagg cgtttttgta gttgagattt tgcggtcgtt cgatactttc 12001 gaaaagcatg gtttcgaagt ggacttcgtt tctgagactg gtggatttgg ctgggatgaa 12061 cattacttgc caaagagctt tattggtggc gaagataaga tgaactttga aacgaaaaat 12121 tccgccttca ataaggcgtt agcgaggatc aagaccgcaa atgaagtcaa cgccagcgac 12181 tataaaatat tctttgcatc tgctggacat ggtgctctat ttgactatcc caaagctaaa 12241 aatctgcaag atattgcatc caagatatat gccaatgggg gtgtgatcgc tgccatctgt 12301 catggaccgc tccttttcga tggattaata gatatcaaaa caacaagacc attaatcgaa 12361 ggcaaagcta taacaggttt cccactcgag ggtgaaatcg ccctgggagt tgacgacatc 12421 ttgaggagca gaaaattgac aacggttgaa cgcgttgcaa acaagaatgg agccaagtac 12481 ttggcgccaa tccatccctg ggatgactac tctattacag atggaaagct agttacgggt 12541 gttaacgcaa attcttccta ttcgaccaca attagagcta taaacgcatt atatagctga 12601 aacaaaagac aagggaattg ttgaagggga ggcttctaat ggctttcagt ttctgtgaag 12661 agaaggctaa cagctcaatg gttcgaaagg taaagaaaac ggcaggtcgg tagcactcga 12721 ttttgctaga atggaaatca tatagagaac aattgaatag taggccttgg tttttagtgt 12781 tgtactcatc atggtcatat gtgacatagg taatgtacat atatatataa aaaaaaaaaa 12841 agcaatgctg tgagatcatt cgttacttac gaaatacgca gattgcaatt tgaaataagc 12901 tgtgttttct tttttttcct ttttttttct tttttttggc ttgttatata caactttttt 12961 ctatttctgt tctttttaga agtaattaat tggtacatag gaaataaata tgaattatat 13021 taaatgaagt aaaagtaaaa gaaaacgggg aaatttatcg ttttgtagta aatagatgat 13081 ggaacgcatt cataaaatct cacaaaatat tacaataaac cgcagtagtc ggtaaaaatg 13141 tattatacaa cgtctaaaat cttgaaaatg aattaaaaaa aaaaaaaggt gggatgattg 13201 tgcaggaaaa ggtatgaaga aaagatccta acaaatcggg ttagtcaatc ctctagtcca 13261 agcataggat ccgagagtta tcaccaataa gcaatatgaa attccaatcg aaacagtata 13321 ataaataagc atgttaataa atgatagctt atacccttca ttgataaacg tgctaatggt 13381 actcaaagtg ccgcaaaatc cggatattaa cgcagaaaca atatggcatg aattcaacga 13441 gttcacaatt ggaatatccg tggaaaagtg ttttttacca cgttgcacca tggtaaatat 13501 gccaatcaat aaagtggcga aaacgtttgc caagaaagta cccaatggaa actttttgtt 13561 tgttttatta aacatttctg ccaaccaata tcttaggaaa ccagcgaaaa ttccaaatag 13621 acatggtagt gtccacttgc ccctcgaata gttctcataa tacgcacaca gcaccacaaa 13681 caaaataatt aatggaaaag ctagtgcgta cgcgagttta tccacaacat caaaaaattt 13741 cttaaaaaat ggtgctggag ttttgaattt aaactctaga atattttttt ccatttcttg 13801 tgtatcaaca tcaccagcat tttcctttac agtgtctgag ggaggggtat atggcttcga 13861 aaacgaacta gatccataag caacaataac ctccttacca agttgcctac cgaaaataag 13921 actacccatg gaaaccataa gatgaacgag caagacagat aaaaactcca ttataccgta 13981 agctctgttc ggcagttttg tgtggttagc gatattaccg ttagttaagt ttgtagagtg 14041 ttcgaacatc tctagcagca tactagaaaa ggaagacagg gcaccacagt acccagtagt 14101 tacacctaaa aacaagactt ggtgatcttt catccaagtg taagcattta aagattgcat 14161 aatccccatt agcatgcagg atgaacaatt agaccagaga acggtcggag cagtaacgaa 14221 ggccggagtg taggtggaaa gcgccgttat agcctgacgt gtttcagtac ctaatatgca 14281 gaacgtggtg aatgtacaaa aaacatgaat ataatggctc aacttgtgat ttgatatgac 14341 cggattgaaa atcatcagag cattacacgc tcgattaaat aattaaataa ctgcagattc 14401 ttgagccacc agacgctaaa taataatggc ggcaataaat ataatccttt agtacttatt 14461 tcagttgttt tttgttttat tttttccgta tctcttccgt atctcttcca tcattgcgtc 14521 aaaagtgatt tacactgcta catgaatcgc gccactttat gtcagtgaat ctttcataca 14581 tcgcaactcc tcactgacag tgactctagc agagtcacca tcttttcgat atacccatca 14641 aagtgcacga ttctcctccc ctgttagaca atcgtaacgt aatatcgaca tgtattcgta 14701 gcaccgctgc caaataattt tcagatcgtt cattgtacat gaaccaagcg ctgttgcttt 14761 actttatgat attgctgctg agctcccttg tctttcatac gacgttttat cttgatttca 14821 tatctttttt ttttggtaaa atagaaaata ctcaacagat atctgatatg tatataaaca 14881 ctaaataaag aaaatcttaa atcttgctgg catgactgtc gctgtgtctc aaatctctta 14941 gtaattcata gatgtgtatc accccaaatc tcaaaaactt cataattatt attggattat 15001 ctagaaatca tacccttcat actgtcccac aatggcctgc tcacatgagg cgctaatgat 15061 tacgattaac catcaaatca tttatattga tacactgtag tttactgtta ataaccaacc 15121 tttgtcgaga ttcatcaaag tgggttccaa atccctcatt gtgggaacct ggttcagtca 15181 tacccattgg agatgggccc caggaaggag tgtaacaaac ttcatcccaa ttgcattgcc 15241 tctcacaacg gtaatttagt tcaatccacc ctagagattc aattaaacca tcgatagtgg 15301 agcgagccgt ttcgacattc tttattaagt cgctggaagt tgtgttatct gtcataaaag 15361 agtagacttc gggtatcaat aaatcattca ctttataaat gacatcaaca atttctccga 15421 caacgctgac agcagatgac caaatcaaaa agtctgcatc cgtttttaag gcctggtatg 15481 ggctcacata ttggtagaca aaagttcaat gtgagtgctg ttgcattgat ggcaattgac 15541 tcattaatat caccatcgct gttcagtatg ttactaacag attttagtaa tggagcaaat 15601 ttaaggacaa gctcatcaaa tgctaactgc caatccatac tttgcgtggc atcaaatccg 15661 acttccagcg ccttttctaa gtcatctacc atgtccaatt gcttttccca tgtcattcct 15721 tcatcgagta atcttctgtt gttaggatca ggagcaatgt acgtcctgtt tatcccgctc 15781 actaggtacc tatagtcgat atggattcga tgctccccgt tgtcatgcgc tgcacccgct 15841 ctcaactgat tgaagctttt aactgcgttg aaattagaaa aagccttctc ccaaccatct 15901 tctctttcca gaatcgcctt ttggtcatct gttagctgat cttcaactag gcttccattt 15961 tcatccagag gccaaccttc ttccttcgat attacggtag gtgctggtaa gcctaggtac 16021 tggttaggct ggaccatttc taacattgaa acaagttcga cgttatcagc cgaaaaatca 16081 cacaaaacga cctcaaagcc aacctctacc ctgataattc cgtcaagccc gaatggcttc 16141 ccccatttgc atattctagc agcgtagagt cgttcggcca ttcgttcgtt ttcaccatca 16201 tctgtaaggt tcaatttctc tttaataaca tttgacaaca ttagctgcgt gtccatctct 16261 cctgagtcag ttttcgcagc agaagcccca tcaagataga gaaatttgtt gaggtcccgt 16321 gctgctctat aagtaagcat tttttgtgaa ccccgacctt tttcgtctgg tggtggtggt 16381 ggtggtggtg gcccttttgg atgatcaccg ttggtgccat tgccgaacct cccatgcctt 16441 ctttccaaag attttctccc ataggatggt gacctcaagc cgaaagagta gctgaattca 16501 tggtccatag ctagccattc gaaggtagtt ggcacttttg atccggcatg gtacattaaa 16561 gttcctttgg gaattacagc gggaaaataa gatactccga caggatgtat atccgatgga 16621 gactgtctta aagcagcccg aatggaatta aagatagccg tactgttatc aaaatcaatg 16681 tctctgacga actcatggta attatcccat cgtatagaag gtaagtctgt gcttttaatt 16741 gcagattgat tgtgtggtag ggcagttgat actatgccgt aagatccaga taacttccaa 16801 cagaaaccaa gcagtacaat gagtagtacg cctatgatgg ctgagatacc ttgacgatgg 16861 aatcgcattc tctatctaaa cagtggtcaa tggattcttc gagagctaag accatagatt 16921 tcttaaaaga attttttttt ttttttctgt cctcctaata tcttttatct ttaatactgt 16981 aggggcgcaa gtttcttttt tttttttttt ttatgttgcg tttagttttt ctcttggcaa 17041 aagtttttcg caccccgatc tttttttgca tacgtagttc actgccgctg cttacggcag 17101 cgtttcactt tgtttggaga acggttgtta acttgtattt gatatggtgt cgagacaatg 17161 tcattgcaag ttatataaac attgtaatac atcacctcga tgaaagagaa actggaatga 17221 tagatctctt tttctcaaaa tttcgttaat atgtaataat aaggttcctg atgtaatttg 17281 tttttgtaca aattatttta gattctggag gttcaaataa aatatatatt acagccaacg 17341 attagggggg acaagacttg attacacatt tttcgttggt aacttgactc ttttatgaaa 17401 agaaaacatt aagttgaagg tgcacgcttg aggcgctcct ttttcatggt gcttagcagc 17461 agatgaaagt gtcagaagtt acctattttg tcaccatttg agaataagct tgaaagaaag 17521 ttgtaacccc aacttttcta tcttgcactt gtttggacca acagccaaac ggcttatccc 17581 ttttcttttc ccttataatc gggaatttcc ttactaggaa ggcaccgata ctataactcc 17641 gaatgaaaaa gacatgccag taataaaaat aattgatgtt atgcggaata tactattctt 17701 ggattattca ctgttaacta aaagttggag aaatcactct gcactgtcaa tcattgaaaa 17761 aaagaacata taaaagggca caaaatcgag tcttttttaa tgagttcttg ctgaggaaaa 17821 tttagttaat atatcattta cataaaacat gcatattatt gtgttgtact ttctttattc 17881 attttaagca ggaataatta caagtattgc aacgctaatc aaatcgaaat aacagctgaa 17941 aattaatatg tcgaagggaa aggttttgct ggttctttat gaaggtggta agcatgctga 18001 agagcaggaa aagttattgg ggtgtattga aaatgaactt ggtatcagaa atttcattga 18061 agaacaggga tacgagttgg ttactaccat tgacaaggac cctgagccaa cctcaacggt 18121 agacagggag ttgaaagacg ctgaaattgt cattactacg ccctttttcc ccgcctacat 18181 ctcgagaaac aggattgcag aagctcctaa cctgaagctc tgtgtaaccg ctggcgtcgg 18241 ttcagaccat gtcgatttag aagctgcaaa tgaacggaaa atcacggtca ccgaagttac 18301 tggttctaac gtcgtttctg tcgcagagca cgttatggcc acaattttgg ttttgataag 18361 aaactataat ggtggtcatc aataagcaat taatggtgag tgggatattg ccggcgtggc 18421 taaaaaatga gtatgatctg gaagacaaaa taatttcaac ggtaggtgcc ggtagaattg 18481 gatatagggt tctggaaaga ttggtcgcat ttaatccgaa gaagttactg tactacgact 18541 accaggaact acctgcggaa gcaatcaata gattgaacga ggccagcaag cttttcaatg 18601 gcagaggtga tattgttcag agagtagaga aattggagga tatggttgct cagtcagatg 18661 ttgttaccat caactgtcca ttgcacaagg actcaagggg tttattcaat aaaaagctta 18721 tttcccacat gaaagatggt gcatacttgg tgaataccgc tagaggtgct atttgtgtcg 18781 cagaagatgt tgccgaggca gtcaagtctg gtaaattggc tggctatggt ggtgatgtct 18841 gggataagca accagcacca aaagaccatc cctggaggac tatggacaat aaggaccacg 18901 tgggaaacgc aatgactgtt catatcagtg gcacatctct gcatgctcaa aagaggtacg 18961 ctcagggagt aaagaacatc ctaaatagtt acttttccaa aaagtttgat taccgtccac 19021 aggatattat tgtgcagaat ggttcttatg ccaccagagc ttatggacag aagaaataag 19081 agtgattatg agtatttgtg agcagaagtt ttccggtctc cttttgttct tgttttggcg 19141 tattctccac tattcgtcca tagcacattt ataccttagc taaatatttt gtaaagcaaa 19201 attttcgtta tctcttaaaa aatagaagag cggtttatta atatcaaata attgaaactg 19261 ctgatatggt agctatatac aaaatctgct gtcaaaattt ggcagtaaac gatcttcacg 19321 gtagcggttc aaataaagag gaaaagtcct tctcccttac tgtttttctg gaatttggct 19381 cgtcgttaat aacagaacta aagatacagt aaaaggagag atcgcaatca acttcattaa 19441 ttgtaacagt agcataatca caactggtta tctgcgttat agacaattct tactcacaat 19501 gatgggcgct tagttggctg taaacgtcgc tttttaaaac tccgaaaagt taccgctaca 19561 gaaaaaaacc ataaatgtat gctagttgcg cagagaggtt tagggtccaa aatttactac 19621 cctgtcgctc actacagcga ctgtcccgaa ttaagcccga agagacgcag aactgttgta 19681 tgaacctcat gaaaccactg atcttgaaga tttagacctt cagaatcgtt ttcaattaga 19741 agtatacaag aagtctttgt acaataatgt caagacagag ctctgaatta tagttcagcc 19801 ttgttatttt tttttccctg gttgctaatt tgtatcttgt ctaatgaaaa taatttgagg 19861 caacgtaatg ttaccaatgt acaactgttt ttttcctctc gttagcttcg ttcttgctgt 19921 attcacgagc tttttttttt tgactcttcc ctaaattctt atatcaagtg taattttcaa 19981 taatatttga ttccagttta gcgtacctcg agttttgcct acctaaaatg caaatgcgat 20041 ctgcaagaat ttctattgaa agtacaactt tagttccaaa tctccaattt ttgattgctc 20101 aaaagtaaat gatactttac cgtccctaga cttcggaggg cctaatatat tctcaagtat 20161 attcaaattt atgacgccag taaaggtaaa tatattatga atatagaagc cacagactta 20221 gatgtttgta ttaggagatg ctttccttgt cgacgcatat gttgtctatg acatagaaaa 20281 cccacggact ttcaatgctc aggcaagttt taaaaatcgc gaagaagaca ttaaaataat 20341 atttgataaa gccgctggtg ccatttcgct tctgatgctt tagctgatgg tttacgcatc 20401 tagtagccga attggaacag aatatttctc tgacatagcc atgcctatag agtctacaac 20461 tttttggcgt ctgtaaatat tcttctacag ccctgatgca agtggaagtt ctacttgttt 20521 gaatagttca agtttcaatg aaaggaccat caagaagaaa aattgggagt atagacgccg 20581 tcgatcaaat gtctcctttc cattattatc ttccttatct tatcttcttt ctatatggtt 20641 tgcatagcgg aaaagacaca caggcgggaa ttttacaatt taataacctc ctttatacgt 20701 ccgctttttt acatatatgt gttattcatt agttgtacga tacccttcat gtctttattc 20761 actgaccaat ctctcctcta ggaaagttca ggggcaccgt caattgatag aacaaagcaa 20821 acactatgaa tactttcttc tggtacacat aacaattgct agggtctgat ttcaaaatga 20881 tggtgatgat aaaaataagt cctgcttctt aaagcttttg acattaccgt gtacaaaatt 20941 atcagaccat cttcctcttt tctgagaatg aaatgaaaaa ttttgtaact gacatagcgg 21001 agacagtttc acaagtaatt tggtgctaac tgttgtttga cctttaggaa attttctagt 21061 aaaaggaaga attcatatga agatggtagt gttttaatgt gggtgctttt gttatgggag 21121 tgctacaatg ataggccatt gtcaaagttt ggaaacagta gacttcaatg gtaaataaag 21181 ttaaatttaa ggcgattccg atgaaatctg tctttcagaa ggtttgttat ctctaatgct 21241 aatctttaac atttacgcca cttggagtgg aatatacgtt caagttcttt ttgacatgca 21301 ttctggtctc gacctactaa cttcttacgc tactttcttg gattggatgc gttgcttcta 21361 gtacctcttc ctgcaaaact tgatcctata attggaacag ttcttgcaca cctttctttt 21421 gattgacggt acaaaaattt tagctttctc aggaacttcg gcgtttttga gcagattcag 21481 ttgcattctt cagcagtaac acgctggagt ttttacgaat gtaggcagta taaagcagga 21541 tcatgaagta tggtgaactg gatgtgcgca gaaatccgac agaatacgtc aaaaatattg 21601 tacgtgtcaa acttcccttg taaagattgt cgagtttatt ttgacactat ggtgttggca 21661 ccctctgctt tgtttttagc ttacaattga ggagagatgc ataagcatat ttgtttttct 21721 tacgctgagc aatagacagg aaaataaatg gcgcttacta ctcaacccac tgtgttagaa 21781 ccaaaaacaa cacagcttca aaaatgatac gtgccatttg atggtaatac agaggccgta 21841 gtagtgtttc aatcaataga atactagaaa ttgcaacaca ggtcaaaaag agaataaaaa 21901 aatgttaggg gttcatagtt aaaaatatga tatgtttttg agtttgggga gaaaaggctg 21961 cttttgttcc atagtgcgtc ttttaaaaat tttcatcctt gttattatca aactttttcc 22021 tgggcggtaa cctagctgaa taagaacgat ttggctgcaa tcgccgagaa aacaaccaag 22081 ccaagaattc ccaaaaggga tatgcttgca tccgcattgt tccctcggtt ctactaataa 22141 gaaagagtaa gagacaatgt ttagcgctat taagttatgc tatggttaca tcattttggc 22201 ggactggatc atgtctgtcg agaaaaactt gaccgataat tcaacgaagt attggtgcct 22261 aagctttgca tcataatatc ttacaagttt tgctgagaac agatagaggc ataaatgaat 22321 gatttacgtc ttattttttg ataaggaggt atcgacgtct gccagcttaa gaatatgaaa 22381 tctggcgcat gatttcttca aaataactca gatattgtca agaacagccc actattgctt 22441 ggaagtgaaa atatacgcca aaagtgcatt ttactttcta caattcacca cagtcttcga 22501 gatatattta tcatttaaat cacatggaca cccaccgaac tggttacaag ctatattcgc 22561 atcacacaga atgatgtggc gtctatgcta tacggcgatg ttactatatc attaacctct 22621 cttttcggtt ccgagcgctt tcggctcaag aactggggat gactaaaaaa aaagaactgt 22681 gtacgtgatt tctttgtccc ctgcggttgc atagacatcg ctgtcgcacg gcaagagcgc 22741 acacagtcat cagtctacaa aacctaactt ttcaagagca accagtataa atattttgag 22801 ccattgaggg cataaagcga aaggcacatt ttcaaaattg gtcttaggtt catcttctga 22861 tgttatgtcg agagctctga aaaccaatta ttttgaaagc taacatttca aaaggctatt 22921 tcttctgaaa tatcaagatg gatatactca agaggggaaa tgaatcggac aagtttacga 22981 aaatagagac agaatctact acgataccaa atgactcgga tagatctggt tcactgatca 23041 gaagaatgaa ggattccttc aagcaaagta acctgcatgt cattccagaa gaccttgaaa 23101 acagcgaaca gacagagcag gaaaaaatcc aatggaaact agcttctcag ccctatcaaa 23161 aagtcttgag ccaaaggcac ttgaccatga ttgccatagg tggtactttg gggacgggac 23221 tgttcattgg tttaggttat tctttggcat ctgggccagc cgctttgcta atcggttttt 23281 tgttagttgg tacttcaatg ttctgtgtcg ttcagagtgc cgcagagctt tcctgccaat 23341 tcccggtttc tggctcatat gccacacatg tcagtaggtt catagatgaa tcggttggct 23401 ttactgtggc tacaaactat gctttggctt ggctgatttc ttttccaagc gaattaattg 23461 gttgtgcact tactatttca tactggaacc aaacggttaa tccggctgtt tgggtggcca 23521 ttttttatgt tttcattatg gtactgaact tgtttggtgt gagaggcttt gccgagactg 23581 agtttgctct gtcaatcatt aaggttattg ctatatttat tttcatcatt attggtatcg 23641 tccttattgc cggagggggg cctaactcta ctggttatat tggcgccaaa tactggcacg 23701 acccaggtgc cttcgcaaaa cctgtcttca agaatttgtg taacacattc gtttctgctg 23761 ctttttcctt tggtggtagt gagttagtgc tgttaactag tacagaatct aaaaatattt 23821 cagctatatc acgtgctgcc aaaggtacgt tctggagaat cgcgattttt tacattacta 23881 ccgttgtcat tattggatgt ctcgtacctt ataacgaccc cagactgctc agtggttcga 23941 acagtgagga tgtatctgcc tctccctttg ttattgcttt gagtaataca ggatcaatgg 24001 gtgcaaaagt ttccaacttt atgaatgtcg ttatccttgt tgcggttgtg tcagtttgca 24061 attcttgcgt ttatgcttct tcaagactaa ttcaagcttt aggtgcatct ggccaacttc 24121 cttcggtatg ttcctacatg gacagaaagg gtaggccttt ggttggcatt gggattagtg 24181 gtgcatttgg tcttttaggt tttcttgtgg cctcgaaaaa ggaggacgag gtcttcactt 24241 ggcttttcgc cctttgttcc atttcatcat tcttcacctg gttctgtatt tgtatgtcac 24301 aaattagatt taggatggct ttgaaagctc aaggaagatc caatgacgaa atagcttaca 24361 aatccatact gggtgtttat ggtggaattt tggggtgtgt gctaaatgca ttgctaattg 24421 cgggtgaaat atacgtatcg gccgccccgg tcggtagccc tagctccgct gaagccttct 24481 ttgaatactg tttaagtatt ccaatcatga ttgttgttta ttttgcacat aggttttatc 24541 gaagagattg gaaacacttc tacatcaaga ggagtgagat cgatctggat actgggtgtt 24601 ccgtggagaa tctagagctt ttcaaagcac aaaaagaagc tgaggaacaa ctcattgctt 24661 ctaagccatt ctattacaaa atctacagat tttggtgtta gatggtactc ttgcatatgt 24721 aacctttaat aaattttgca aatcgaattc ctttgtaacg tgcaaagcat tttatagcct 24781 ggcgctcgca ttgttaagca acaggcggtg cggcaacgtt gaaatgtttc acgcagggtt 24841 ttttacgtac tgcacggcat tctggagtga aaaaaaatga aaagtacagc tcgaagtttt 24901 ttgtccatcg gttgtacttt gcagagtatt agtcattttt gatatcagag tactactatc 24961 gaagcatttt tacgcttgaa taacttgaat attattgaaa gcttagttca accaagctga 25021 aaagaaccat tattcaacat aattggaaat catttcgtta ctaaatcgtc cgaaaattgc 25081 agaaaaatgg cacgtcttcc tctaaagcag ttcttagcgg ataaccccaa aaaagttctt 25141 gttcttgacg gtggtcaagg aacagaactg gaaaacagag gtatcaaagt tgcaaatccc 25201 gtgtggtcta ctattccatt tattagcgaa tcattttggt ctgatgagtc atctgctaac 25261 agaaaaattg tcaaagaaat gttcaacgat ttcttgaatg ctggcgcaga aatattgatg 25321 actacaacat accaaacgag ttataaatca gtttctgaaa acaccccaat cagaacttta 25381 tccgagtaca ataacctttt aaacaggatt gtcgattttt ctcgtaattg tattggcgaa 25441 gacaaatatt tgattggctg tattggccca tggggtgctc atatttgtcg tgagtttaca 25501 ggcgactatg gtgctgagcc agaaaatatt gatttctacc aatacttcaa gcctcagttg 25561 gagaatttca ataaaaatga caaattggat ttgattgggt ttgaaaccat tcctaacatc 25621 catgaactga aagctatctt atcttgggat gagagtatcc tgtctagacc cttctatatc 25681 gggttgtctg tgcatgagca cggtgtcttg agagacggca ctaccatgga agaaatcgca 25741 caagttatta aggacttggg cgacaaaata aatcctaact tctcgttctt aggaatcaac 25801 tgcgtcagct tcaaccaatc acccgacatt cttgagtctc tacatcaagc actaccaaat 25861 atggccttgc ttgcttatcc aaacagtggt gaagtttatg atactgaaaa gaagatatgg 25921 ttgccaaata gcgataagct gaacagttgg gatacggttg ttaaacagta cattagcagc 25981 ggtgcccgta tcattggtgg ttgttgcaga acaagtccaa aagacatcca agagatttct 26041 gcagccgtca agaaatacac gtaaatgcgt ttttaaagaa gttaaataat tcttaacatt 26101 atatatatgc taaaagcagc atgttacact aaatacattt tataaacaat agaaagtatg 26161 ttaatacaat gcttttcaaa gcgaccatga ctttccgtac ttggccgaca aaaaaacaga 26221 gtaaataaaa tgtctattat aatcgggcga gaattaataa actagcagtt tagcacagca 26281 gaatttaggc atacacgatg gatgaaaagg tgtagccaca cgaacctgtc gagatccctt 26341 tttctgtcta ctaaatccac ataggccaga ctatttcgta aagatatgtc ccctgaatgc 26401 cgcagcttgc tgtatttacc gtcacttctt tttgctcagt tatactggaa atgacggcct 26461 cggcatgcca aagttccaga aacagtgcaa tttcctgtca tatctcctat caatagtttc 26521 tttagcatat atgttgatta aattttgata agaataaata aaatggaaaa aatacgtact 26581 atacagacat atatttaatg cgtcacctgc ctattcaata aaggattcga agcattctac 26641 aaaagattct aaattatacg aatcagggta gtgaatacag atattcaggc ccatctcttc 26701 acagtatgta taggaaagag acattaatgt ggggcgattt atcgaacttg taaatcccgt 26761 acttacaatt ttgaaagatt tgtcatcgcc gttcatcgat aacgatatgt cggaaacatc 26821 attgatttga atcaattttg tccttgaatt ttggatatgg aaatcgtcgt cattgtcata 26881 cttcatcctc cttatatcgt catcattaaa cccattcttt tcccaactcc tcagttttgc 26941 cataataaaa ccgctaacgt gctttgtaac tttattaaat tgatattcca tcaatctttc 27001 attaaactca tcatcattat cctcgttatc gttactgttg gtcaaaaatt cgttggcgga 27061 aagttcgtca tcaattagag aaagtggaca ttcgaccctt agttctttga agaagagacc 27121 caatgaccca cctaagccta agtggtttct taaatttatg ggaatagtaa atactattgt 27181 accgctgaaa tccttaacga gaggttttaa acatatcatt gcaataccac agatgaaact 27241 tcttagacat atatgctctt gattaacgat tgactttaaa tagttaaacc tttggttgtt 27301 tactatccca aatactgttg tcccgcataa tgaggtgtgc gcatttagaa tatcattata 27361 ctttttcagc tgtgttgcag atactgacga gctgagggaa gtttgattgg ttaaatagcc 27421 gaaaggtctt tttaaagtgt tatagtatat tgatttgaaa aatgactgag tttgcttgtg 27481 gaagatttgt ggtgtcatag cgggcaggtg taattttgcg ctatcatata tcgatttggg 27541 aaattttaat tctgagagat tgatgtcatt gacatcaaac aaaatcctat cttcagagtg 27601 tgttactgtg ctgatttcgt ttaactcttt taaaaataat ttgtgaaagt tagctgctga 27661 aaatatatca aacaatacgt cgtgaccatg aaaaaccaat agcgcttcgt caattacata 27721 tagtgtccat aaaggtttat ttgatccggg aacaaatcta gtcttgttga aggcatgacg 27781 caagagataa ggaggtggaa caccccaatg gcaattgacc tccttatctt ttatggtttc 27841 aaactcaatc acattaacaa tatcggaagt tttcagctgc ttcaatggct cgaattccca 27901 ttcttcgttt acagttgcaa acaatgccgg ttgcgattta atcaatctct tcaaagttgt 27961 tgctattagg ggcagagtca gacgagaatc atctttggaa gaatttgttc cgagcgtgac 28021 ttcatcagaa tgccagtcag cgtcattttc tctacttaaa gattttgaat atgtactcga 28081 aaaaatagtt ccatttcttt ggtcattcaa agattgagtg agaatttttt tttcaaaact 28141 tgatagtggc ctaaacgtag tcattatgat aaagtgagga tgtgtctgtg ttgtgagtta 28201 caaatgcact tctttggaca ggtataacaa ggataacgta tacacccttt tatatatgac 28261 cgtcccccca tacaaatttg tgctcgtatg ccgagtgtga tctactcatc gcttcgttaa 28321 tgaatcgttt agccaagaat atagtaaacg tgtagcagag tcatacccct gatggctgca 28381 gacgcaggga atactcagcc tcgaaacagt tttcaattta tgtgcgtatg catggctata 28441 atcttctatt tctgtcacct ttcgtttatt ctaaacgaat ttgcgacgtt caacgaaagc 28501 gcgttgaaaa aattaatctc tgaagttaaa cggtcggaaa acagacaaaa aagttgttgt 28561 tattacttgt agaggaaaga gctatttcat agctcgtttg ggaatgcagg ggtgacgtcc 28621 ttcttcgggt gtgttgtcct aactttcctt aaacacattg ggctatcata ccagtgaaaa 28681 agaaacatac aatggtcaga ttcgctttat ttggctacga gaatgtggcg gctaagttcc 28741 ctcaacaact attccaccaa tcttgatggc ttttctaagg ctctaagtag acgttaaggt 28801 ggctaagatt ctaaaatttt gccatttttc gaggttgtgc ttcgccctat cccttggaaa 28861 acatttctaa tcatcttaaa ttctgtgatt gagaacgttt taacgttatc ttaaacgttt 28921 ccatagaaga acgaacgtga aggtttgtag ctcgttaaaa ggcgatcttg aatgatgtga 28981 agaagtgtaa aaggcttagg aaagttgctt gttgacccgg tgtcgttcaa tatactccta 29041 ttacccaaat ggcagtttca tagagtgata ttatttcgtt gccttgtgta agttagaagt 29101 acttcttgtc gattgtgaat tcggatagcc gctagaacgc caatcattgc ggaggtttgc 29161 catcgcatgg ataccatagc catctgcaca ttctaatata gattatatta ctttagacca 29221 tgtcatttca taatcgttgg tttaagcggt gttgtttcca cagtttgtat gagaactttt 29281 gtccaaagta aagtatcagt aacgtaatct gagcaaacct acattaaatc gtaactccgc 29341 gagattcttt tgttcaggtg gatcagcggc gtggtttact tccgatttgc tcatcgtgcg 29401 catagcagca tttattcctc taattcgctc gataatcaac ctttccgcac tacgacggtg 29461 gcaatagttg gaccttaaga tatgcctatc tgaatacaat tcttcaactc acatcagtgg 29521 gacactaaat aaagcatatg gtatgaaata ctatgaatta ttgaattatt ggcagacaca 29581 gcagcgacaa gtcagagtgc ttacaaaaaa aaaagagttg atccggctaa agaaagtctg 29641 atttacgtat ttatccaggt tcaaacggat tgccaaaaat agtcgataac ctcggagtaa 29701 gcaaagcaac aatatatttg ttcttcgaaa aggtaaactt cttaacttct atagaagcat 29761 tgtactagtt ctctcgaaga aaaaaactaa gaaagctata gctgtatctt accaagccat 29821 gaacttgagg aattggtaat ccttattagg aaatacgcta aactaggtaa tagcagatga 29881 tttactagct tactatctca cactaagtct ggcaacgcgc ttatttttta atacttttat 29941 acgaaccaat gaaatttgat cctccccttt ttcgtctagt taaatgaaga gatacaagta 30001 ggcctttcta ttgagtactt agcaagatat gtatttctaa gaaacatcaa cagtttcagc 30061 ccacaaccga ttcataaaat gtctgcctgg aggaaagctg gtatatcata tgctgcatat 30121 ttgaatgtgg ccgctcaggc tatccgttct tcattgaaaa ctgaattaca aaccgctagt 30181 gttcttaaca gatcgcaaac agatgctttt tatacccaat ataaaaatgg cactgcagct 30241 tctgaaccca ctccaataac aaaatagttt aacgcttcct gggaactgca gctctttttt 30301 tactcgctga tatacatttt aaatattcta gcaactgtgt atgaaaactt acgtactttt 30361 atacgggaaa ctaataatga ctacaatgat attgaatact ggccgcttcg aagagtggta 30421 taaagtttgt atcattgcat taaaagaaaa agaaatatat gtcccatcat cgccaatcgc 30481 aatgttgaat ggtcgtttac cacttttgcg gctgggcata tgcagaaaca tgctgtcccg 30541 tccccgactg gctaaactgc catctataag gtttcggtct ttggtcaccc cttcttcatc 30601 gcagctcatt cctctcagtc ggttgtgttt aaggtcacct gcagttggaa aatcactaat 30661 tttacaaagt tttagatgta attcatccaa aacagttcca gaaacttctc tgccttcagc 30721 ctctcccata tctaaaggat cagcaaggtc ggcacatgca aaggagcaat ctaaaactga 30781 tgactataaa gatataataa ggttatttat gttggcgaaa cgggattgga aactgcttct 30841 tacagccata cttcttttaa ccatatcatg ttccataggc atgtctattc ctaaagtcat 30901 aggtattgtc cttgacacac ttaagacgtc atctggatca gatttttttg atttgaagat 30961 accgattttt tctttgcctt tatatgagtt tctttccttt tttactgttg ctttactgat 31021 tggttgtgct gctaattttg gtagatttat attattgagg atactaagtg agcgtgttgt 31081 tgcacgccta agggcaaatg tcattaaaaa aacgcttcat caagacgcag aattcttcga 31141 caaccataaa gttggggatt taatttctcg tttaggatct gatgcttatg ttgtttcaag 31201 atcaatgacc cagaaggtct cggatggggt caaagcccta atttgtgggg ttgttggcgt 31261 ggggatgatg tgttctttgt cacctcaact atcaatattg ttactattct tcactccacc 31321 tgttcttttt agtgcctcag tgttcgggaa gcaaattaga aacacctcta aagaccttca 31381 agaagctact ggtcaattga ctagagtcgc tgaagaacaa ctctctggta tcaagacggt 31441 tcagtcgttt gttgctgaag gtaatgaatt gtctaggtat aacgttgcaa ttagagatat 31501 ttttcaggtg ggaaaaactg cggcatttac aaacgcaaag ttttttacta caactagtct 31561 cttaggtgac ctaagttttt taaccgtcct tgcgtatggc tcctatcttg ttttacaatc 31621 acagctctcc attggtgatc tgactgcatt tatgctgtac acagaatata cggggaatgc 31681 ggtattcggc ctttctacct tctattcgga aattatgcag ggtgctgggg ccgcttccag 31741 gttgtttgaa ttaacagata ggaaaccttc catttcaccg actgtgggac acaagtataa 31801 accagatcgt ggtgttatcg aatttaaaga tgtttcattt agctacccta caaggccttc 31861 tgttcaaata ttcaagaatt taaattttaa aattgcgcca ggatcgagtg tttgtattgt 31921 gggcccttca ggtcgtggta aatctacaat tgcactctta ctgctaagat attataatcc 31981 cactactggg actattacga tagataacca agatatctct aaattgaatt gtaaatccct 32041 aagaaggcat attggtatcg ttcagcaaga gccggtactg atgtcaggta ctattaggga 32101 taatatcact tatgggttga catatacccc aacaaaggaa gaaatcaggt cagtagcaaa 32161 gcagtgcttt tgccataact ttatcacaaa atttccgaac acatacgata cggtaattgg 32221 tcctcacggc accttactaa gtggaggaca aaagcagcgt attgcgattg caagggctct 32281 aatcaaaaag ccaactattt tgattcttga tgaagctaca tcagctttag atgttgaaag 32341 tgaaggagcc attaactata cgtttggtca actaatgaaa tcaaaatcga tgactattgt 32401 tagcatcgcg cacaggctaa gtacgatcag aagatcagag aatgttattg tccttggcca 32461 tgatggatca gtggtagaaa tgggcaaatt caaagaattg tatgcgaatc caacaagtgc 32521 tttatcgcaa ttacttaatg agaaagcggc tcctgggcca tctgaccaac aactgcaaat 32581 agagaaggtc atcgaaaagg aagatttgaa tgagagtaag gagcatgatg accagaaaaa 32641 ggacgataat gacgataatg ataataatca tgataacgac agcaataacc agtctccaga 32701 gacgaaagac aataattcag atgatattga aaaatctgtc gaacatctcc tgaaagacgc 32761 ggcaaaggag gctaatccaa ttaagatcac accacaaccg tgagtcatcc gcatcgcata 32821 tacccattct tatctcgcac atttaaatat atactatata taatactgtt aaatgccaaa 32881 taaaaaggat tttcattacc cgaatcgata cttttggtag cataaacaaa taacattgaa 32941 acaataacaa agtgtaatgt ggccgcacga atctttgtct gtaacagcct taaagatttc 33001 agtagcactg ccatggataa tgatggaccc agatctatga ccattgggga tgacttccaa 33061 gagaactttt gtgaacgttt agaaagaatt cacaatacat tacattcaat aaacgattgc 33121 aactcattga atgagagtac cacaagtata tcagagacat tgttagttca attttatgat 33181 gatttggaga acgttgcctc ggtaattccc gacttagtca acaagaaaag actgggaaaa 33241 gacgatattt tgttgtttat ggactggtta ttattgaaaa aatatatgct atatcaattt 33301 attagtgacg ttcataatat tgaggaaggt tttgctcatt tgttggattt actagaggat 33361 gaattctcga aggacgatca ggatagcgac aaatacaatc gatttagccc gatgtttgac 33421 gtcatagaag aatctacaca aattaagact cagttggagc catggcttac taacttgaag 33481 gaattattgg atacgtcatt ggaatttaac gaaatttcaa aggatcatat ggatacatta 33541 cataaaatca ttaatagcaa tatatcgtat tgtctggaaa ttcaggaaga aaggttcgcg 33601 tccccgatac ggcatactcc atcatttacc ctagaacaac tagtcaagtt attaggaacg 33661 catacggaga caactgagcc aaaggtacca aaattttctc cggcagaaga tattttatca 33721 agaaagttct tgaacctaaa aaaaaatatc cctccaattg aaaaaagttt gactgatatc 33781 ctacctcaaa gaattgtgca atttgggcac cggaatataa caaacataac tactttgcaa 33841 acaatcttgc aaaaaaaata cgagctgata atgaaagatt atagatttat gaattcagag 33901 tttagggaat tgaaagtcga actaatcgac aaacgttgga atatactctt tattaattta 33961 aatcatgaac tattatacat tcttgatgag atagaaaggt tgcagtcgaa attactgaca 34021 acaaagtata ccaaagatat cactataagg ctcgagaggc aattggagag aaaatcaaaa 34081 actgtttcta agacattcaa tattatttac agagcattgg aattctcact tttggacgct 34141 ggcgtcgcat cgaagacaaa tgaattagct caaagatggc tgaatatcaa gcctacagcg 34201 gataaaattc taatcaaatc ctccgcttca aacaaaatag ctactagcaa gaagaagatt 34261 ccaaaaccga aatcattagg ctttgggcga ccgaatagtg ttattggaac tataacccag 34321 gatttccagg agagagtcgc cattaatgaa ggtgacagta ataaaacacc ggaaaattca 34381 actacagtgg ctttgaaagg taaaaagctt ggtaaagcgt tactgcagaa gatgaatatt 34441 aaacctgcaa caagcccaaa ttcatcaaat gcgattaatc cattttttga tccggagtcg 34501 ccaaacaaag gaaaactgat actaagtagt gttcctccct taccttatga cgaaaccgat 34561 gaaaccaccc tccgtgtttc tcgtggggaa aatgaaaagt caccagactc cttcattaca 34621 tctcggcatg aaaataaagt acagattaca gaaactcctt tgatggcaaa gaataagtct 34681 gtgcttgaca tcgaaaaaga taaatggaat cattaccggt ccttgccctc taggatccct 34741 atatacaagg ataaagtggt gaaagtcacc gtagaaaaca caccgatagc aaaggttttc 34801 cagactccgc caacaaaaat cacgacacct aatagtcaag tttgggtccc ttcgacaaga 34861 agaagaaccc gattgaggcc tcccaccccc ttatcacagt tactttcacc aagagaaggg 34921 cgtttagata aaaccccaac ttattgatac taacctaaaa ctgtatactt atacattttt 34981 atatatcctc cctctcaccc tctccattca tagaatttgt aatactagtt taaataatgt 35041 aatattatgt gtaattttaa atagtccatg aagattccgc acgttttcat tttacagttt 35101 ttgacacctt tacccgacgc tttataaaaa aaatagtata agcatcacga cataagcagc 35161 ctcaggtcat taaaacaata aaagactggg aattataaac gtacaacggt aaggtcattc 35221 acgcagtgta tatgaatgac tgaaagtgct atagatgacc aaaggtttaa tcttacaaag 35281 gagttacaac gacactcatg cagagatcaa gggaaaataa cacaaaagga tgatgcttta 35341 gattttataa gttacagttc ttttcaatcc tcttttaata ctgaccaaaa aagcgcgaac 35401 aatggaagta ctgtgagaag aagcataagg tcgattttta gaagagcagc cgaattgcct 35461 agagtccata tggggcctct tacttattca catgggataa atgagcttgt taacaagaaa 35521 ttaagaaaag actgtgatct cagcacgcta tgtcgcgtat tgcaaagagg aatcaggatg 35581 attaggatga caagaagaag aaggaagttc tatgaattta aattaatcaa taacaacggg 35641 caaataatat ggaaagatgg ttcgaagtat ctggaattag actccgttaa agacatcaga 35701 atcggtgata cggcgagtac ttatcaagag gaagtagatc cgaaaagatt gagatcggac 35761 agtaaacttt ggattgctat tatttataag gtttccaaca aattgaaagc gttacacgta 35821 gttgctttga atgaattgga ctttaacaca ttcttaagct gcatttgcgg tttagtgaag 35881 ttaaggaggg aattaatgga aagcatactt ttgcctgata attcgcaatt cgctaggata 35941 cattggcaaa ttactgtttc tgaaaaagag gaagatgaga aaaaggacac attgagcttt 36001 gcagatgtga agaaactatg tgataaattt catatttatg tgtcaactgg tcaattgtta 36061 gagtttttcc aattagcaga catcaatcat aacggactat taaattattt tgaatttgaa 36121 aagttcatta aaatcttaaa gaataggaaa gaggtaaata tgatttggtc taaatttaca 36181 aaacctccac actcccactt atcatttgaa aatttttttc aatttttaat tacagagcag 36241 catgagcaag tggatcgtca aactgcatgg tcatatttta ttaagtacag agaaccgact 36301 cagctgacga tggggcaaga tggttttacc aagttcttga aggagcaacc atatttggtg 36361 gaggttaaag aggagttata ttcaaagcca ttaaaccatt attttattgc atcttcacat 36421 aatacttatt tattggggaa acaaattgca gaaactccat ctgtggaggg atatattcaa 36481 gtcctacaac aaggttgtag gtgcgtagaa attgatatat gggatggtga aaatgggcca 36541 gtggtatgcc atggattttt aacgtcagct attcccttaa aaacagttat acgcgtgata 36601 aagaagtacg cttttataac gtctccgtat cctttgatta tttcactgga aataaactgt 36661 aacaaggata atcaaaaatt ggcaagcctg ataatgagag aggttttagc agaacagctg 36721 tactttgttg gcacaagaac tgataaactg ccatcaccaa gggaattaaa acataaaata 36781 ctgttgaaat ccaagaagac gagtgaagca actagaggtc ttagcgttaa tgagccattt 36841 ccatcttctt ttagttcttc ttacgaatca gctaatgaac aggaattaag aatgaaagat 36901 gactccacga acagtagtag cgcaacaaat tcttctagta tgcaacgcat caaaagaatt 36961 ggattaaaaa agcacgctga tataattaat gatgtttcta acatttctgg aatacatggc 37021 atcaagttca ggaatttctc tttaccagag tccaaaacga tagcgcattg tttttcactg 37081 aatgagcgca aagtagaata catgataaaa gacaaacact taaaattatc gttggataaa 37141 cataatagaa gatatttgat gagagtctat cctcacgttt tacgatacaa atcatcaaat 37201 tttaacccaa tacctttttg gaaggccggt gtacaaatgg tggctacgaa ttggcaaact 37261 aatgatattg gacagcaact taatctggca atgtttcaaa tattagatca ccaacctgat 37321 ggaagtttta aatcaggata cgtgctaaaa ccaaaaaagt tgctacctgt agtaacaaag 37381 gcgaaaatga ttccattaat ttacgaacat tttgaaaatg gtagtgatcc tgttactgtt 37441 aaaattcgaa ttttatctac acagttattg cccagattga atgatacatc gccaagcaga 37501 aataacacca attcctttgt taaagtggag tttcataccg atgacgagcc gacaatgccc 37561 atctcaatcg ataagggtac aaggatttct gccactgaag catccactaa gagttctcaa 37621 gggaatggat tcaacccaat atgggatgct gaagtttcta tcacattgaa agatacagac 37681 ctcacattta taaaattcat ggttatctct gaagagaccc agattgcatc tgtttgcctt 37741 aagctgaact atttgaggat gggatatcgt cacattccgt tgtttaacat ggagggggaa 37801 caatacatat tttgcacttt atttattcat acacaaattt tataggcgat ctttttccgg 37861 ccaaatacac atattcataa atacgtacat atacctactt gcatatacca acatgattac 37921 ctagaatgga tatatcaaat gggacgacga agtaccacga caatacacaa taacaacttc 37981 tgtttttcgc tgattgcctt ctcttcagca gaaagttgat gcatatttcg cgtagcgcgt 38041 tgacgcgtct tctttctgaa gttttgtgct tttgttatca tactatataa agtaaaaaga 38101 aaggagaaca tattaagcat tactgaatta ggatcctttg gaagaaataa agtaagagac 38161 actgaaagat gatatcacca tcaaaaaaga gaaccatttt atcaagcaag aatataaacc 38221 aaaaaccacg agcagtggta aaaggcaatg aacttcgttc accatcaaag agaaggtcac 38281 aaatagacac agactatgca ctaaggcgaa gtccaataaa gacaatccaa atttctaaag 38341 ctgcacaatt tatgctgtat gaggaaacgg ctgaagaaag aaacatagct gtccacagac 38401 ataatgaaat atacaataat aacaattctg tgagcaatga gaataatcct tcccaagtaa 38461 aagaaaacct ttcacccgct aaaatttgcc cttatgaaag agcattttta agggaaggag 38521 gaagaattgc attgaaggac ttaagtgttg acgaattcaa aggttacata caggatcctc 38581 tcaccgatga gactatacca ctgacgttgc cactgggtga taaaaaaatc agcctaccca 38641 gttttataac gccgccaaga aattcgaaga tatctatttt cttcactagt aaacaccaag 38701 gacagaaccc agagacaaag atatcccgtt ctaccgatga cgtcagtgaa aaaaaagtag 38761 tgagaaaact gtccttccac gtctatgaag atgagtaaat aatgtacaca gttagcgtct 38821 aataattaat taacgatacc aatttaattc attcacgtat tcctcacctc gtgtgtaaat 38881 tactaacaga gtagtaataa taataagaat caataataat aataaatcca tccttgtgta 38941 ttacccgggt tagagggtag aaaaattttt gaaaatcgcg atgagctgaa aattgaaaat 39001 atttggttat aacataagat cgataaatta ggaacagtgc attatacagt ggactcattc 39061 ggttagaagc tttagacgtc gtacctttta tatcgataca aataaaaata aaattatacc 39121 atgggaaagg ctgcgaaaaa gaagtactcc ggagcaactt cgtccaaaca agtctctgcc 39181 gagaaacatt tgagttcagt atttaaattc aacacagatc taggtcagca tattttgaaa 39241 aatcctttgg tggcgcaagg tattgttgat aaggcacaga ttagaccctc agatgttgtt 39301 ttggaggttg gtcctggtac aggtaaccta actgtaagga tcctcgaaca agcaaaaaac 39361 gtagtggcag tagaaatgga tcccagaatg gctgcagaat taactaagag ggtacgtggc 39421 acacctgtgg agaaaaagtt agaaatcatg cttggagatt ttatgaagac tgaattacca 39481 tactttgata tctgtattag taacactcct taccagatct catcgcctct ggttttcaaa 39541 ttaattaacc aaccaagacc accaagagta tctattctta tgtttcaaag agagtttgct 39601 ttaagattac tggcaagacc aggtgactca ttatactgta gattatccgc caatgtacaa 39661 atgtgggcta atgttacaca catcatgaaa gtgggtaaga ataacttcag accgccacca 39721 caagtggaat ccagcgttgt tagactagag attaaaaatc caagaccgca agtggattac 39781 aacgaatggg atggtttgtt gagaatcgtc tttgtgagga aaaacagaac gatttcagct 39841 ggcttcaaat cgaccaccgt gatggacatt ctggagaaga attataagac atttttggcg 39901 atgaacaacg aaatggtgga tgatacaaag ggttctatgc acgatgtcgt caaggaaaag 39961 attgacacag ttctgaagga gaccgactta ggcgacaaaa gagcgggtaa atgtgatcaa 40021 aatgatttcc taaggctatt atatgctttt caccaggttg gtatccattt ttcatgagct 40081 ctcttatcaa ttatgtaagt gcttgtatac tatttaccta agataagaaa aaaaaaagca 40141 attcaaaatt aagcttatct tgacagcggg gctggtttgt ttctagaaga caaaaagtgg 40201 ggaatcattt ttacgtaact ccccctgata agaaggactc acatccttat aggtacgata 40261 aagaatggtt gtatctttcc tatttttcga aatcgttatc ttatatagtt gaactactac 40321 ggttaaaaag cttaagcctc agccctctta gtcaaacttc ttttttgaag gcaccagggt 40381 gcataaaagt gcgtctattg tttcccagtg gaactctgtt gagatagcga tgtttgtttt 40441 tttttcactt aacggcaacc aataccgata gcgacgtcgc tggcagtgta gagtggccgt 40501 acggcgtcgc tagatggcac ggcactgatt gcggcgggag tcgctaggcg gtgatgcatt 40561 tccgcacagg gaccagagga agcttcccag gcggtgacag taagtgaact cattatcatg 40621 tcttctccaa aacattcgtg acatctagtc atgctcctcg caattcactc cgattggtat 40681 agctttttcg gtagttttag ctactatgct taggggaaag aggagaaacc gtaccgtcag 40741 tctcagtcaa aaaattttga tattcaatct gatagcaaag ttggaacttg gggttatctg 40801 gccctttttt gttatcatat tcgtataccc aacaacatat cggttccacc ggtccttttt 40861 atatataaaa gacgatgtgt agatgcactc gagtattctt ggagaacgta acttgtattg 40921 agctagagtg ctggataaag taccacatac taacgttctt ttatagagcc aaacataatt 40981 cttttgcact ttcaatataa ggtacaagtg aaacacagga aaaaaagaac taactctaag 41041 taatgaagat gcctctaaag aagatgttta ccagcacgtc tcctcgtaac tcttcttctc 41101 ttgacagtga tcatgacgct tactattcga aacaaaatcc tgacaatttc cctgtaaagg 41161 agcaagaaat ctataacatt gacctggaag aaaacaatgt gtcctctcgt tcatccacct 41221 ctacatcacc ttcagcaagg gacgactctt tcgcagttcc agatggtaaa gacgaaaaca 41281 cgcggttgag gaaagattta aaggcaagac atatttctat gatcgccatt ggtggttcat 41341 taggtacagg tctgcttata ggtacaggta ccgccttatt gacgggtggt ccggttgcga 41401 tgttaattgc atatgccttt gtcggccttt tagtctttta caccatggcc tgtcttggtg 41461 aaatggcttc ttacattcca ttggatggtt ttacaagtta tgcctcacgt tacgtggatc 41521 ctgcattagg ttttgctatt ggttatactt accttttcaa atatttcatc ttacctccca 41581 accaacttac tgctgctgct ttggtcattc aatattggat cagcagagac cgtgttaacc 41641 ctggtgtgtg gattactata ttcttggttg ttattgtcgc tatcaatgtc gtcggtgtaa 41701 aattctttgg tgaatttgaa ttttggttgt ccagtttcaa agtcatggta atgttgggtc 41761 taatcctgtt actatttatt attatgcttg gtggaggtcc taaccatgac cgcctagggt 41821 ttagatactg gcgtgatcct ggtgcgttca aagaatattc gacggctatc actggtggta 41881 aaggtaaatt tgtttcgttc gttgctgttt tcgtttacag tcttttcagt tacacgggta 41941 ttgaattgac aggtatcgtt tgttctgaag ctgagaatcc aagaaaaagt gttccaaagg 42001 caattaaatt gacagtttac cgtatcattg ttttttacct atgcaccgtt ttccttttgg 42061 gtatgtgcgt tgcatacaat gaccctcgtt tactttccac aaaaggtaag agtatgtctg 42121 ctgcggcatc tccattcgtg gttgccattc aaaactcagg tattgaagtc ttacctcata 42181 tcttcaatgc ttgtgtcttg gttttcgttt tcagtgcttg taactcagat ttgtacgttt 42241 cttccagaaa tttatatgcg ttggcaattg atggtaaagc gccaaagatc ttcgctaaga 42301 caagtagatg gggtgttcct tacaatgctt taatactctc cgtgctgttt tgtggcttgg 42361 cgtacatgaa tgtgtcttca ggatcagcaa agattttcaa ctactttgtt aacgttgttt 42421 ctatgttcgg aatcttgagt tggatcacca ttttaattgt ttacatctac ttcgataaag 42481 cctgccgtgc tcaagggatt gacaaatcaa aatttgctta tgtcgctcct ggccaacgtt 42541 atggtgctta ttttgcttta ttcttctgca ttttgattgc tttaatcaaa aacttcactg 42601 ttttcctagg tcataaattt gattataaaa cattcatcac cgggtatatt ggcctgcctg 42661 tctatatcat ttcttgggct ggttacaaat tgatatacaa aaccaaagtg ataaagtcta 42721 ccgacgtgga tttgtacaca tttaaggaaa tatacgatag agaagaagaa gagggaagaa 42781 tgaaggacca agaaaaggaa gagcgtttaa aaagtaacgg taaaaatatg gagtggttct 42841 atgaaaaatt tttgggtaat atcttctaga tgccttttta atcaaagcct tagggcaaca 42901 tgaaactata ttcatccaat caaaaaaatg agcacaagaa tttctctttg atcatttttc 42961 ttttaccttt aataacaatc gttatcaaca ttttttattt ccagtcctac cacagcatta 43021 ttgcataatt aatttacagg aagattttct tgaaaaaata gaaagaaaaa tacccatttt 43081 ttcaaggaaa ataaaattta tatattacat acatttctat aaaacagttt aaattcaaaa 43141 atataaacaa aaacataaaa ataagaaaag ttcaagtctt cgttattttc tgtttgtgga 43201 gtaatcgatc ttattaacat atatgtggag acttttcaaa tatagccacc tgcaacatgg 43261 aaccatagtg tacaggtatc acttaatcct ccaaatcatc taattcaaag tccgatgtgg 43321 agagtagctc ggcagtagcc acaacgtttt gtttggaggc tctcatatta atgacccata 43381 tagtagaact aacgataact gccataccgc accacgtcca tatgtttggc cagtggtgaa 43441 agagcacgac atcccagaaa acagcatata taacttgagt ataagtcatt aacgaacccc 43501 ttcctgcacg ctccctctgg attcccattg ttaacagaat ttggtgaatg aatccagaaa 43561 tacccaagtt cagaaatagc ccccactgct tccacgaatg aggcagttgt aaagacatcg 43621 agggaattag aagcacaccg agggctgcca caacagtagt aaccaacgag aaataactga 43681 cactcatgat ggcatgtgcc ttgttaccga tatatcttat gataatgtaa acactactca 43741 atccgcaaac ccccaataaa ctcaccccga tagcaatgag tcttaatttg ggattttgag 43801 tctcaacaat atcgtcttgt ggagattgct ggccttgggt ctgctcacca aacaaaaatg 43861 taggtctaat aattaacacc actccagaaa atgaaattag ggaccccaag gcttcaagtt 43921 tactaaatgg ctcacccagc agtaaaaatg aaaggaaaat ggttagggtt ggcgacatga 43981 aggtgattaa gacagcgtca cttatactta gatacattaa agaaaagtac attccaaaaa 44041 caccaaaaaa acccattata cctcggagta tcaaccattt cctgcatggt gctgggcccc 44101 atggaatatc tggaacactt tgtttattcc aatgcatgta tactagcgta caacagtacg 44161 tgatagacat ccttactagc aggatttgca gaggattaat tcttgattgc gaagtttcca 44221 gtgggtcatt ttctaggact ttggtagaaa ctaccataga agaattgaaa aaataagaca 44281 ctataagtaa gataagtcca taattaggct ttagataatc tttactaatt ctttgcagcg 44341 tcattgagag aggaggtgtt tattctactt ttctgttggg gcagctttcg tgaatgtaat 44401 aatgagataa ttttccctgt ctcctttgtt tttttttcca gatgactcaa ttagtgacta 44461 aagaaaagga tgccatatgg aagacagata tctataaaaa aaaaaaatgc tataaatact 44521 ttttaaactc aactacaaaa gcgaaaatgt ttaccttctt ttggaaggtt tagtagtcgt 44581 atctctttca atgattccgc ctgtatcctc cagacgctct tcctcaaggg tcacctgatc 44641 tcttctttcc caccaacggt cttcacataa ctcaaatgac ttcgtcttta actgtttacc 44701 cttaaggttt ctgttgttag aaatagacca ggttaagaaa tttgcacctt cccttaagta 44761 gaatgctctt aaagtttcga acggttttgg gtgtggtagc caagaccttt cgtctggaat 44821 ctccatctgc gcttgtttgt catcgtcgct ctcgctttcc tcatcttcat caccttcaag 44881 gggtcctgca tcttgttcct cttcgccgtc gtcctcatcc tcctcatcgt cctcgtattc 44941 aaactcatct tcgtccgaat ctctatcacc tagtctcttt gcttcttcga tggcagatag 45001 gtcttcccag taaaccttga caccatccaa cttgttcaaa tctatactat aaaatgagtt 45061 tataggataa tctttttcgc ccagttccca gacaccactg taaatgaaca acgagtcgcc 45121 cactacacaa gttgctgcgt taaatcttgg gtgaggtaat tgatttgaga tggtaatatc 45181 ttcttggttg tccaaatcac tgtcatcttc gttatcttcg tcgtcatcga tagagttagg 45241 acccgttgtg ctgttgtcat cattgtcatc gtcgtcgtca tttagattag acttggccag 45301 aatggaattt agtaaatcct gcagttcctt ttcttgatct ttattagatt ttcttttact 45361 tgtggcgggt gaatttttac tattcgtttg acgctgaggt ttaattctaa gtttagacca 45421 tttgttcaac tctaggtgga acatatatag gtcgttatag aaaacggact ctaaggattc 45481 ctctgtctct tgtaaatcgt agacaccacc aaaagcaacg gacttgtttt gcttccatag 45541 attgaacgaa tacccgactc ttggtgaggg ctggttcttg aaattcttta atttttccca 45601 ctgccacttc tttggatcag gcgttaagtt cagtttccat gcatcattca agatttttcc 45661 cttcattaaa tttttattat ttttggcaat gattttacag taaccaccca ttaatatggc 45721 agaattatct gtaggaatga aacaatgacc cgatctagcg tcaggtttgc tgtttgtctc 45781 caatttggtc catttgtagg ttgagatatc aaaacaccac aaatcattta ggtaagaagt 45841 ttgaccattc cccaaatctc taaatccacc aaataatatg aaatagtttt tccaagcaat 45901 aattctatga cctgatctgg cgctgggtga agagtctcta ccgccaaact ccaacttagt 45961 gaatttcctt tcaacgcagt caaacagcca tgtatcagaa tagtggtaga atttagattg 46021 ttttggggac gaaaattcac caccgtgtaa cagtgctatt ccggaaggat gcacagcgac 46081 agcggcactg gatctgggca aaggtgcatt ttgcgaaacg tattttttcc aagagttgtt 46141 ctttatggag tatgaataca aatcattata gaaatgtgtt agtttggttt ctggatctgt 46201 aaattcacca ccgaaaatga acaattcatg tttattgtgt tgcggatttg caaacatcaa 46261 cggatgagta cgacaagagg gtttttccac agaagtgatg tctacatgct ctaattcaat 46321 ttgctttttg ctaaagctag agagaatttc atcgagatct tgatcacttt catcatcttc 46381 ttcgccgttt aaagacttat tcttgttctt ctgaaacttt ttctcctgct ttttttggtt 46441 tttctgattc ttcagttcag cacgtgcctt tttggcctct ttatccttct tattcttctt 46501 tgccattaat cacttctacg agtctagtag atctcttctc cttcctataa gtggttaatg 46561 tattcttcga gaagctcatc attttttttt ttcatttttt tttttttttt cagttttcta 46621 caatttcatc aaatcaatgg ttaaaccggg cagaaaaact accaagcgtt acttttactg 46681 atgttagtac tactaccgca gttattgcga ctactacatt aactataact atacaagaaa 46741 aaaagtaaag agggctcgta aagcaaagct tggtatctcc tacatagtca atacatagta 46801 gtgagtcgcc tatagccatt ctgtaatgcc atttgttaag acgtgtcctt aaacccttcc 46861 gaatcgccgc gggcgacatc ataatgtcag tacctaataa tggttattat tcgtaccctg 46921 tggttagaga gctatggaag ctagcagtaa atgtctctag ttcttgctat cactaccata 46981 ttggagaggc ttcaggcccc tcccctgagc cgatcctcgg aatgactacc ccgattcccg 47041 gaatgggcgt tcgatgattg gctctttcct gtaaagcctt tttgcgtttc ttataggcta 47101 tatataatct tcatcactgt tgtagacgtt aaacaagcat ccaacaggag gccggaccga 47161 acacacgggg gagtgactct agctctttct tctgggatat tcatatcgtt tctccattac 47221 atacagtcat ttttttgcat ttttaaattc gtgactttta gtactgcagc tgtttttttt 47281 ctcacgtcaa gaaattccat aaagtctaac tattaaacgg ataagagata caatcatgtt 47341 gagatttacc aattgtagtt gcaagacttt cgtaaaatcg tcatataagc ttaatataag 47401 aagaatgaac tcctcgttca gaactgaaac cgatgcattt ggtgagatac acgtgcctgc 47461 tgataagtac tggggtgccc aaactcaaag atcctttcaa aacttcaaga ttggtggcgc 47521 tcgtgaaaga atgccattgc ctttggtgca tgcatttggt gttttgaaga aatctgccgc 47581 gattgtgaat gagtctctgg ggggattgga tcccaagatc tccaaggcta ttcaacaggc 47641 cgctgacgaa gtggcttctg gtaagctaga cgaccacttt ccattggttg ttttccaaac 47701 gggttccggt acccagtcta acatgaatgc taatgaagtt atttccaatc gtgccattga 47761 gatcctagga ggcaagattg gatctaaaca agtccatcca aacaatcatt gcaaccaatc 47821 tcaatcatcc aatgatactt tccccactgt catgcatatc gctgccagtt tgcaaattca 47881 aaacgagttg atacctgagt tgaccaattt aaagaacgcc cttgaagcca aatccaagga 47941 atttgaccat attgtgaaga tcggtagaac acacttgcaa gatgccacgc ctttgacact 48001 aggtcaagag ttttccggtt acgtgcaaca agttgagaac ggtatccaaa gagtggcaca 48061 ttctttgaaa acattgagtt tcctggcaca aggtggtact gccgttggta cagggttgaa 48121 caccaagccc ggattcgatg tcaagatagc cgagcaaatt tccaaagaaa ctggactaaa 48181 gtttcaaacc gcccctaata agttcgaggc tttggctgct cacgacgcca ttgtcgaatg 48241 tagcggtgct ctaaacaccc ttgcttgttc tcttttcaaa atagcgcaag atataagata 48301 cttagggtcc gggccacgtt gcggctacca tgaactaatg ctgccagaga atgaaccagg 48361 ttcctcaatc atgcctggta aagttaaccc aacccaaaac gaggcattga ctcaagtgtg 48421 tgtgcaagtc atgggtaaca atgcagctat cacgtttgcc ggctctcaag gtcaattcga 48481 gttaaatgtc ttcaagccag tcatgatcgc caatctattg aattcgatca ggttaattac 48541 tgatgccgca tattcattta gagtgcactg tgttgaaggt atcaaagcca atgagcctcg 48601 tattcatgag ttgttgacta aatctttaat gttagtcacc gctttgaacc ctaagatcgg 48661 ttatgatgcc gcttccaagg tcgccaagaa tgctcataag aagggcatta ccttgaagga 48721 aagtgcattg gaattgggtg tattgactga aaaggaattt gatgaatggg ttgttcctga 48781 acacatgcta ggtcctaaat aaacgagcta aatacctaat aatatacaag ttttttatgt 48841 cttattatat gaaggaaaat aaggaagtgg agagaatttg tgattcagca atggtccctc 48901 cgctaaggtc ccgcctctgg ccagttatgt cagaagagga gcataggcat acattccatt 48961 tttgatggct taatggggcc cataaattta catcactaca ttattattcc tatacaagtt 49021 ataataaaat agttcataaa tgaatatttt gcgtcatttt ttaatttctt gtcgtcgggt 49081 aagggaccta gtattacccg catcacggaa aggggaattt tcagaaatga taacgaataa 49141 gagagtacac cagaagagca aatctcttta agaagtttag cagcaaatat cggtttaaaa 49201 acaaacaaaa gcaaaggaaa agaactacta aatcttcgag gactttccca atttttaaaa 49261 cgctgaaatt gtattagaag agaataactg tctaaaaaga gcatgtttgc atccgctgga 49321 caacaacacc ctcaaattgt tcctaaggaa gaggaatcca tattaaacta cctccttgaa 49381 gtgagatcct ccttggctaa actcaagcaa aataggaccc agtatttgaa ctctaaggat 49441 gtccaaacta cttaccaaca cgtcttgacc aaagtcagag agttggacga tattaggaag 49501 aatagtcatg agacgcccgc taagagcgcc gccaccctga ttcatagtac tgaattgcat 49561 aatagagttg actccgtact ggatgatgtc tttcaattgc tctcgttgtg ttttttaact 49621 gttgggctaa aaaattctgc acctgcgact tatgcatcgt tatctactgt ggagagtctt 49681 ttggaacatt taaatgaatc aaacgtcttc acccatcacg atttgagtcc tattaaggaa 49741 aggctggaag aaatcagcaa gattgtcgaa caaaaaaact ctagtcctgc gtacgatgag 49801 gatggaaatg atgaccgatt aagggaaatc gacaacgaaa ggaaaaagaa taaaattgag 49861 gaagacctat tactacgtgc taaattaaag cattgcaagg acgaatatga tatattggaa 49921 ggcaaattgg aggaaattga tccgtctttg tctactgtaa tggaaaagtt attccgaatt 49981 agaagaggtt tattgtcatt agttgcatct gctaaaaaaa caatgtctaa atctgatatt 50041 aataccaact ctttattgca ggaacaaaat gatttgcaaa cgaacaatga aagcttaacg 50101 gatgacaaac atttagtatc tcaagagtat gtccatgaga aattatcagt tttgaagaac 50161 gaattaagtg aattagaatc taatcgtgac gattctggta aattcaagtc cttggagtct 50221 catcaggtgg cagaaaaagg ccaaagtgtc cttaatggtt tattggatga ttgccatgat 50281 ttagttaacg atttatcaca ccaaaaaaat ggcgggttga ctttagatcc atatttacag 50341 ccaatatatg aacagctgat tgatataaag actaccttag aaaatttaat gatcacaaga 50401 agatggactt tgagagaaac cgatttattt tcttaccaaa aaaaattgaa cgaaattgat 50461 aacaaaagaa tcaatggtaa gtttccaaca aaatctcagg actcaaaggg gcaatcaata 50521 cttttatacc tgttgcgtag atgttatgcc ataatttata aactgttgga aagttcagag 50581 cccgtatctg aagcgttgca gccaattcac aatcaactat ctacagttcg tcgttgccta 50641 ttagaattga aaagaatggg aggtgtgaat aatgaaagag agttataccc ttatcaaatg 50701 aaattggctt cattggacaa cctgagaact gaaggtatat tctatgactc tgatggcaat 50761 atacctgaag gccaaggtat attgaatgct ttattagcag aatgttttga tatcttgcat 50821 gaattaaaag tggaagccga ggaaaaagca cagaactcta cttcaagtga tggttctgac 50881 gacgatgaca acggagaatc aggcatagac tcgaactcaa acgacagcga gcctgaatct 50941 gaatatcaac aggaatagag gagagtgttt ctttatcttc catttctccc tattttcttg 51001 gtagaggaaa acattataaa caataaaatg aaatacagaa agaaaaaaag ttattctctt 51061 atgtctatgt atataacaaa ccctgaatga gcatctatat aaaaacaaaa atatataaac 51121 aactttatgt cattatcata attgtcaatg ggagggggga gaaaaagagg aataaggaca 51181 tacgtaccct gtgtctttgt ccatgcaccg tagaaattgc tttttttata tatttttcag 51241 acattacgtc agccttattg tataatcatc accactttgc gtgatatatc ttacccatgg 51301 gtaactctta tactgcaatt tgggttcgtt aattttaaga taacgtactt gaatacctga 51361 agtagtaaag tagggtattt gaaatttgat ttggacaggt cccttcaaga tttccgcgtt 51421 actttttggc attgttctat tgccatcctc gttatttgat attgaaggca gtcccaattc 51481 ggcagacatt gagtactctt taccaccggg aaaacttctt attttccata agattgcact 51541 tttttcaggg acatacttta gagacccgtg tgaatattta aaagtcggtg tatccgcgtc 51601 gtccgggacc ggtatcaata tctctacatt agttgcagta gattttcttt taatttgggc 51661 cttggcctta cagtgaattt caattctaga attcgaatga acttgaacgt ttacatcaca 51721 ccaaattaac ggttttatcg tagtagatag tctgtagttc attaaatcga actttccatc 51781 aggaggtata aacgttataa ttttttcatt ctcgaatttg cttaatcgga cacattgatg 51841 aaatttcaaa tcttccaatt caatattaac tttcttcttg tttgtggccg atgatgatgt 51901 tattgatggt tttttatcag tttctgtgtt attatcggat gttgtcgcgc tcgctgatgg 51961 gatatttgta tcatcatcca aatatttgga gaaaatgcct ttatcattaa tacctaattt 52021 cagatcaggc ataccagaca attttgagtt aaccttaaca tcgccgataa tttctgatct 52081 caaaacttga cctttttgag tcatgagcat attaatagat tcgacgatat ccagaaaggc 52141 ttcatttttc ttgtgagtga tgccttctgg cctccaactg actgaatttg ttagtgcgac 52201 gggtggtcta gtagcattcc tcttcttctt ggcggattta actagtttga aggatttttg 52261 tgttatgtac tgtttcagca tcttagtttc tgtgatctgt ggtataccat aatccatcac 52321 ttcgtccagt aattcatata ttataacaaa attatctcta atagattctt cttcaacggt 52381 ttttaagtag tcacttaata cctccactaa tttgtgcaaa aaagtaaaaa tggcagccgc 52441 attggcacta agagaagtca caattgccac cacgtataga tcgttatgct gtataaatag 52501 atattccaga ccattgtggt tcaaacatgg aggaatcaga tttgattgtt cctctaaatc 52561 cgagagtaat atagggaatt tgtcaattgc agaaagcgga atatcatctc tataccttct 52621 tgataggagt ggtttcccat tatgatcgca aaaatacact gcagaagcca ttctgtgtcc 52681 ctccaagttc gtaatttaca attttcaaaa atactcctat atttaattgt acgacttagt 52741 ttctctatat gctttttttt gttcagccca ctttccgttt aactcttaat ttttcatcgt 52801 ctagcaatat ttcaatacgt tcaattaaca tcgctatcaa cgactttcaa agactattat 52861 cataattaga gatacccttt ctcgcttagt tgaagttacg tctaatgatg gctatagtat 52921 atcgagcgta ttttatacca ttgaaatatc ttcatcttta ttacataact attatagatc 52981 catagcagtc ctattgatag tatgcagtaa ttttagcgca tagaaaacgt ttatattggg 53041 tcgaatgctc aattattttc agatggagga ataccttgaa gaaaatatat atatataaag 53101 acgcactatt caaataatca tcagtgccaa cattaactgt ttccctaaga tgcgttcagt 53161 tgtgattctt ttttttttat gtcgcaactg tctgtcgtag ttctgtcagc taatgttacg 53221 agaatgtcca actgcagtgt taggtttctg aaagatgaga aagtttctgc cggataagtt 53281 atcaacgaaa ttatggtgaa tacttgaggt atgtgactag gatggtagcg ccgctagaac 53341 gccaaaatca gaacgaagat tttggtttct gccgaacaat ttttactata ttaataaaaa 53401 tgaaggaaca ttcttaaatt attgacacct atttttgcat aattcattat ttctacgtat 53461 aactttttgt atattttgta aaaatcgatg tgtctattca ttcatattct agagcggcgg 53521 tccagaagtt agcttccaat tcacaaactt cagcatatat tgtgaccagt gtatcaagtt 53581 tttctggagg gtatgtttcc aagatgtgat tcaacagctt ttcgccttca agcatagctt 53641 cgtggcacca tgacgatgag taagtttcac accattcacg gtaaacggag ccttctgctg 53701 cagttacttc atccttgatc ttggtcaaag cgtgaacata gcccattaag caaggattaa 53761 gagctataac taactcctgc cagttacctc ttctggaaac atcattaaag taacgacagt 53821 aagcccttaa tgcaggacct ctttgaatct tttgtaagta gtcgggatcc ttaattccaa 53881 attcctccct taatctcctt tcatgttggc aaagcccatt acgaacgcat tcgacaataa 53941 ctagctcttt ctccaggtct tcaagacacg gggatttact acccgcgatg caggaaatcc 54001 tggcataatt gactaagtac aggtaatctt gttcgataaa aaattggaac ttcttaggct 54061 ctaaggaacc gtctgctact tttctaacaa aatcatggtt cacataggag tcccagtggg 54121 gcttaacttt agggtgattt atcagatatt tatagaaact tcctccaggg attttgttaa 54181 gagaactttt gactggcttt ttgtgtacgg catctgatgc agtgaaacat tcgtcactga 54241 gcattttttc taatggaatt tcgatggcgt agacatgatt aattggcccg ttgtccttaa 54301 cagtctcttt cgtgacatcg cagccaatgg ccaccgcatt ttggacgtac tcaataccgc 54361 cataaacgga ttggggaagg gaataaccgc gagccaaatt tgatgcaatg gcggaagcta 54421 gggtgcaccc ggtaccatga gtgtgggttg tattaacaaa attacccttg aaggttataa 54481 acctttgttc ggcccctaag taaaggacat cagtgatgta ctttccttct tcatcattcc 54541 atggaatgtg accaccttta accaaaatat tggaacactt ggtgattttg gcaaggtctt 54601 ttgcgacttc gaaaatgtct cgcaatttgc ttatttctct gtcttcacct aacagtttga 54661 aacactccgg aatgttagga gtcaaaatgt cagcaaaagg tgcgattttc tccgtaatta 54721 aactggctat atcctttcca gctaaagaag agcctgaagt agcaacaagg actgggtcaa 54781 ctactagctt aggtctattt tcgccgagct gcagcagttt ttcgtgcaaa acctcgatag 54841 cagctgtcgt aagcatgcca gtcttgatga cgtcacattt catgtcttgt aaattggcgt 54901 ccaaaatttg ggaaactact tcctttggcg tgttattaat gctgtatact ttaactggag 54961 tttgagcatt caaagcagtg atgcatgtca tagcatagca tctgtgtgca gtgatagttt 55021 tcacatctgc ttcaacacca gcaccaccgc ttggatctgt tccagcaata gacaaaactg 55081 tgggtaattt ttcattgctg gccaaagcga gatatggtgg aggtgtatta atattaactg 55141 tagaataggt cattgtggca agacagttgc tttccttatg tatatttcct aacgtgatca 55201 gatttggaag aataaataat gatgcaaaca acaggtgctg cgtctaactt tgtatagttt 55261 ggctagtgcc tataaataag agcatttctc ttgccagatg gagtagctct aagggtttcc 55321 aatattcagt ctggatgcat cgatctatca gaaaagagaa gctatacata tacgtatcat 55381 taaagaaata cgagatcgcg aagtgagaac agacctggca gttactaaaa aatcgcgtgc 55441 actttcatgg tgtgttacta tggtacttcg tgtgtatatg caaatatggg aagcggactc 55501 taagtcggta ataaaatgat gaaaatcgcg tttcttgtaa aacaaaagcg atttacttta 55561 tttttggtta ccttcattgt tctttcggat atttgaggac attcatagca ttttcatgat 55621 agttctggaa attttatagg ctagtgaaat ttatacagca acttcttggg agtgcgttgt 55681 tgttaaaggc tataatattg agcataaaga atatactata agttattctc gagaatattc 55741 gaatccacaa aggtaatcga taattctata taacaatatc acatcttctt tttcgtattg 55801 tattttgtcg ctcattatcc cattacacta taaatccttt cgtttcagct ttcattaaac 55861 ctgctgtgag cgatgataaa agggacggtt tatcatttct tcactcttct aaacagggta 55921 aagtaattca aacacagaga aactgtacgt ttgtatatca tatatttgtt ttggacagtt 55981 gttacagttg cccgtgaagg tagcaatgaa cctccccttg ttttaacaaa tttgttatac 56041 cagcgaacga tggatgattg ttgagcttga tgcgataatg ttaaatgcta ctcttgaagc 56101 tgagtgtccg ctgtgatgat gatagcggat agcgtcccat ataatgagag atggggaaaa 56161 aaattaattg aaacggacag gaattgaacc tgcaaccctt cgattgcaat cttattccgt 56221 ggaatttcca agatttaatt ggagtcgaaa gctctaccat tgagccaccg cttcaactat 56281 tgttgaaagt gttgtatctc aaaatgggat acgtcagtat gacaatacgt cattctaaac 56341 gttcataaaa cacatatgtt ggaataaaaa tcaactatcg accatcacgt agtagtcata 56401 ctaccaattg ttggaataaa aatcaactat cgtctatcaa ctaatagtta ttgttggaat 56461 agaaatcaac tatcatctac taactagtat ttacattact agtatattat catatacggt 56521 gttagaagat gacgcaaatg atgagaaata gtcatctaaa ttagtggaag ctgaaacgca 56581 aggattgata atgtaatagg atcaatgaat ataaacatat aaaacggaat gaggaataat 56641 cgtaatatta gtatgtagaa atatagattc cattttgagg attcctatat cctcgaggag 56701 aacttctagt atattctgta tacctaatat tatagccttt atcaacaatg gaatcccaac 56761 aattatctca acattcaccc atttctcatg gtagcgcctg tgcttcggtt acttctaagg 56821 aagtccacac aaatcaagat ccgttagacg tttcagcttc caaaacagaa gaatgtgaga 56881 aggcttccac taaggctaac tctcaacaga caacaacacc tgcttcatca gctgttccag 56941 agaaccccca tcatgcctct cctcaacctg cttcagtacc acctccacag aatgggccgt 57001 acccacagca gtgcatgatg acccaaaacc aagccaatcc atctggttgg tcattttacg 57061 gacacccatc tatgattccg tatacacctt atcaaatgtc gcctatgtac tttccacctg 57121 ggccacaatc acagtttccg cagtatccat catcagttgg aacgcctctg agcactccat 57181 cacctgagtc aggtaataca tttactgatt catcctcagc ggactctgat atgacatcca 57241 ctaaaaaata tgtcagacca ccaccaatgt taacctcacc taatgacttt ccaaattggg 57301 ttaaaacata catcaaattt ttacaaaact cgaatctcgg tggtattatt ccgacagtaa 57361 acggaaaacc cgtacgtcag atcactgatg atgaactcac cttcttgtat aacacttttc 57421 aaatatttgc tccctctcaa ttcctaccta cctgggtcaa agacatccta tccgttgatt 57481 atacggatat catgaaaatt ctttccaaaa gtattgaaaa aatgcaatct gatacccaag 57541 aggcaaacga cattgtgacc ctggcaaatt tgcaatataa tggcagtaca cctgcagatg 57601 catttgaaac aaaagtcaca aacattatcg acagactgaa caataatggc attcatatca 57661 ataacaaggt cgcatgccaa ttaattatga gaggtctatc tggcgaatat aaatttttac 57721 gctacacacg tcatcgacat ctaaatatga cagtcgctga actgttctta gatatccatg 57781 ctatttatga agaacaacag ggatcgagaa acagcaaacc taattacagg agaaatctga 57841 gtgatgagaa gaatgattct cgcagctata cgaatacaac caaacccaaa gttatagctc 57901 ggaatcctca aaaaacaaat aattcgaaat cgaaaacagc cagggctcac aatgtatcca 57961 catctaataa ctctcccagc acggacaacg attccatcag taaatcaact actgaaccga 58021 ttcaattgaa caataagcac gaccttcacc ttaggccagg aacttactga atctacggta 58081 aatcacacta atcattctga tgatgaactc cctggacacc tccttctcga ttcaggagca 58141 tcacgaaccc ttataagatc tgctcatcac atacactcag catcatctaa tcctgacata 58201 aacgtagttg atgctcaaaa aagaaatata ccaattaacg ctattggtga cctacaattt 58261 cacttccagg acaacaccaa aacatcaata aaggtattgc acactcctaa catagcctat 58321 gacttactca gtttgaatga attggctgca gtagatatca cagcatgctt taccaaaaac 58381 gtcttagaac gatctgacgg cactgtactt gcacctatcg taaaatatgg agacttttac 58441 tgggtatcta aaaagtactt gcttccatca aatatctccg tacccaccat caataatgtc 58501 catacaagtg aaagtacacg caaatatcct tatcctttca ttcatcgaat gcttgcgcat 58561 gccaatgcac agacaattcg atactcactt aaaaataaca ccatcacgta ttttaacgaa 58621 tcagatgtcg actggtctag tgctattgac tatcaatgtc ctgattgttt aatcggcaaa 58681 agcaccaaac acagacatat caaaggttca cgactaaaat accaaaattc atacgaaccc 58741 tttcaatacc tacatactga catatttggt ccagttcaca acctaccaaa tagtgcacca 58801 tcctatttca tctcatttac tgatgagaca acaaaattcc gttgggttta tccattacac 58861 gaccgtcgcg aggactctat cctcgatgtt tttactacga tactagcttt tattaagaac 58921 cagtttcagg ccagtgtctt ggttatacaa atggaccgtg gttctgagta tactaacaga 58981 actctccata aattccttga aaaaaatggt ataactccat gctatacaac cacagcggat 59041 tcccgagcac atggagtcgc tgaacggctc aaccgtacct tattagatga ctgccgtact 59101 caactgcaat gtagtggttt accgaaccat ttatggttct ctgcaatcga attttctact 59161 attgtgagaa attcactagc ttcacctaaa agcaaaaaat ctgcaagaca acatgctggc 59221 ttggcaggac ttgatatcag tactttgtta cctttcggtc aacctgttat cgtcaatgat 59281 cacaacccta actccaaaat acatcctcgt ggcatcccag gctacgctct acatccgtct 59341 cgaaactctt atggatatat catctatctt ccatccttaa agaagacagt agatacaact 59401 aactatgtta ttcttcaggg caaggaatcc agattagatc aattcaatta cgacgcactc 59461 actttcgatg aagacttaaa ccgtttaact gcttcatatc attcgttcat tgcgtcaaat 59521 gagatccaag aatccaatga tcttaacata gaatctgacc atgacttcca atccgacatt 59581 gaactacatc ctgagcaacc gagaaatgtc ctttcaaaag ctgtgagtcc aaccgattcc 59641 acacctccgt caactcatac tgaagattcg aaacgtgttt ctaaaaccaa tattcgcgca 59701 cccagagaag ttgaccccaa catatctgaa tctaatattc ttccatcaaa gaagagatct 59761 agcacccccc aaatttccaa tatcgagagt accggttcgg gtggtatgca taaattaaat 59821 gttcctttac ttgctcccat gtcccaatct aacacacatg agtcgtcgca cgccagtaaa 59881 tctaaagatt tcagacactc agactcgtac agtgaaaatg agactaatca tacaaacgta 59941 ccaatatcca gtacgggtgg taccaacaac aaaactgttc cgcagataag tgaccaagag 60001 actgagaaaa ggattataca ccgttcacct tcaatcgatg cttctccacc ggaaaataat 60061 tcatcgcaca atattgttcc tatcaaaacg ccaactactg tttctgaaca gaataccgag 60121 gaatctatca tcgctgatct cccactccct gatctacctc cagaatctcc taccgaattc 60181 cctgacccat ttaaagaact cccaccgata aattctcgtc aaactaattc cagtttgggt 60241 ggtattggtg actctaatgc ctatactact atcaacagta agaaaagatc attagaagat 60301 aatgaaactg aaattaaggt atcacgagac acatggaata ctaagaatat gcgtagttta 60361 gaacctccga gatcgaagaa acgaattcac ctgattgcag ctgtaaaagc agtaaaatca 60421 atcaaaccaa tacggacaac cttacgatac gatgaggcaa tcacctataa taaagatatt 60481 aaagaaaaag aaaaatatat cgaggcatac cacaaagaag tcaatcaact gttgaagatg 60541 aaaacttggg acactgacga atattatgac agaaaagaaa tagaccctaa aagagtaata 60601 aactcaatgt ttatcttcaa caagaaacgt gacggtactc ataaagctag atttgttgca 60661 agaggtgata ttcagcatcc tgacacttac gactcaggca tgcaatccaa taccgtacat 60721 cactatgcat taatgacatc cctgtcactt gcattagaca ataactacta tattacacaa 60781 ttagacatat cttcggcata tttgtatgca gacatcaaag aagaattata cataagacct 60841 ccaccacatt taggaatgaa tgataagttg atacgtttga agaaatcact ttatggattg 60901 aaacaaagtg gagcgaactg gtacgaaact atcaaatcat acctgataaa acagtgtggt 60961 atggaagaag ttcgtggatg gtcatgcgta tttaagaata gtcaagtaac aatatgttta 61021 tttgttgacg acatgatttt attcagcaaa gacttaaatg caaataagaa aatcataaca 61081 acactcaaga aacaatacga tacaaagata ataaatctgg gtgaaagtga taacgaaatt 61141 cagtacgaca tacttggctt agaaatcaaa tatcaaagag gtaaatacat gaaattaggt 61201 atggaaaact cattaactga gaaaataccc aaattaaacg tacctttgaa tccaaaagga 61261 agaaaactta gcgctccagg tcaaccaggt ctttatatag accaggatga actagaaata 61321 gatgaagatg aatacaaaga gaaggtacat gaaatgcaaa agttgattgg tctagcttca 61381 tatgttggat ataaatttag atttgactta ctatactaca tcaacacact tgctcaacat 61441 atactattcc cctctaggca agttttagac atgacatatg agttgataca attcatgtgg 61501 gacactagag ataaacaact gatatggcac aaaaacaaac ctaccgagcc agataataaa 61561 ctagtcgcaa taagtgatgc ttcgtatggc aaccaaccgt attataaatc acaaattggc 61621 aacatatatt tacttaatgg aaaggtaatt ggaggaaagt ccaccaaggc ttcattaaca 61681 tgtacttcaa ctacggaagc agaaatacac gcgataagtg aatctgtccc attattaaat 61741 aatctaagtt acctgataca agaacttaac aagaaaccaa ttattaaagg cttacttact 61801 gatagtagat caacgatcag tataattaag tctacaaatg aagagaaatt tagaaacaga 61861 ttttttggca caaaggcaat gagacttaga gatgaagtat caggtaataa tttatacgta 61921 tactacatcg agaccaagaa gaacattgct gatgtgatga caaaacctct tccgataaaa 61981 acatttaaac tattaactaa caaatggatt cattagatct attacattat gggtggtatg 62041 ttggaataga aatcaactat catctactaa ctagtattta cattactagt atattatcat 62101 atacggtgtt agaagatgac gcaaatgatg agaaatagtc atctaaatta gtggaagctg 62161 aaacgcaagg attgataatg taataggatc aatgaatata aacatataaa acggaatgag 62221 gaataatcgt aatattagta tgtagaaata tagattccat tttgaggatt cctatatcct 62281 cgaggagaac ttctagtata ttctgtatac ctaatattat agcctttatc aacaatggaa 62341 tcccaacaat tatctcaaca ttcacccatt tctcagttat actatcaatg ttggaataaa 62401 aatcaactat catctactaa ctagtattta cgttactagt atattatcat atacggtgtt 62461 agaagatgac gtaaatgatg agaaatagtc atctaaatta gtggaagctg aaacgcaagg 62521 attgataatg taataggatc aatgaatatt aacatataaa atgatgataa taatatttat 62581 agaattgtgt agaattgcag attccctttt atggattcct aaatcctcga ggagaacttc 62641 tagtatatct acatacctaa tattatagcc ttaatcacaa tggaatccca acaattacat 62701 caaaatccac atgctctaca atcaatatat tatcatatac ggtgttagat gatgacataa 62761 gttatgagaa gctgcccatc gaagttagag gaagctaaag tgcaaggatt gataatgtaa 62821 taggataatc aaacatataa aacggaatga ggaataatcg taatattggt atatagaaat 62881 ttcgatttta ttttgaggat tcccataccg ccgaggagag cttcgagtat actctgtata 62941 catgatatta tagcctttat caacaatgga atcccaacaa ttatctaaaa attcacccac 63001 atctcaattt tagagtttca tttcaacaaa acgcataaca tatataccaa caatgaatac 63061 tgtatacgtt ttttacaatt tcttttggag aaaactccac tgcctgtgtt ggacttcata 63121 cgagattttt ttcaccgttg atttggaaac actagacaaa ttggagataa aggcgcttcc 63181 ttaaacaaca agcagactgc tatcaagtat agtatacaga tcaccattta tttttttttt 63241 ccccttggta gtatcatata cttttgaaaa gttgtagtat gacagctcat gcaaatgaaa 63301 ggattagcga tgtatcccct agtgctaggg gttcaagttc ggaatcgaag tatgacaagc 63361 tctgccgagt tcttttcttt attgcaatta caaaaagctc attcactccg gagcacatat 63421 tgtataagca ttcaatattt actgataagc caattttagc tgatatagtt acttttatgt 63481 atgcggcgtt tgtttccatt ggatggtttc tgatatgggg ggaaagagca tacagaactc 63541 aagaaatggg tcaacctcca atgtactcga atataaacta tcacctttta agttttaaga 63601 aaagacaccc caagaaattt acatgtgcgt tatggttggt atttttcctt gcatatacgg 63661 ttttgacagt tttaatttgg ttagttcagt tgatttttcg aaaaggtaat gtttttcaaa 63721 tgttattgca acttattata ttagatatcg ccattgcatt ggtcaatgta gcaattgcat 63781 tcacttttga aatatatctt tcacagaaag ccgctatcga gattcgcgac gaaggtttaa 63841 ataatcttga caccgcttaa tggaatggta gtcgaaaggt aagaagtacg cagcaaattc 63901 aaccagaata cacactgtac cttttaaaat tttactcata gtagataatg gcataaatca 63961 gtggtaaaaa aagaatacgc atgacaaatt ttgaaaaccg tacgtgacat aaaataccta 64021 taataagatg aagacatcaa ttctcaagtt ccacttttcg ccggttgagt gtatcggtca 64081 tagtacaaag gcagaaatga ataatagtaa tattaatcgc agtttcctgt tgtttagaga 64141 actgaaacgc tttgtgggca tcaggtttag attaactgct acccttcttc tgtatttgtc 64201 tggccatgct tctcaaataa accgctgcgg ataacatttc aagtggtttc tcaagggaga 64261 atcatagttt agcttaacat acagcaaatc gtcactatct tgactgatgc ccggtgtata 64321 gagaatgggt agttaatatc atctagatgg ggtttctttg aaaacaccag tttctttgag 64381 gacaccagtt tcagtgcttc tctctacccc atcaactatt gcactcctac ctgcgtaata 64441 agtatacgaa gtctaaaata gtgggacgtc ttgctttttt cggtagtttt tcgtttcgat 64501 aaaggcaaca atgctgtata ttgtatgcag gaagttctta aggaaaatac aggaatcttt 64561 agaaaaagaa taaatagctt tccattgtat catgaacaag tcactcttca tattatatgt 64621 cgtcgcttct tatcccttta agttatgaat tgttgagctt aggattttac cacaactgaa 64681 taacattttc tttattctaa taatcgattt tttttaataa gattagactt gagtgccatc 64741 agcaaagaaa aatactttta atgtcctttt tttaactcta cacagaattt agttggctgt 64801 ttcattgatt tacaaaaata taaatatata ccgttaaaat tatagcgata aactgagtat 64861 gtggtctctc ttttcccgca gaatatgaaa gcttttcttt tataaatctt ataatattgg 64921 tctctttttg gtacgtttgg caaattggca ttcatttatc atgaaaagaa caggaactat 64981 attacttggg tattgcccat accaaaagaa attaaagatg aggcactgct agatttaccg 65041 ctatttatgg tcccagttgg cgaggggaac attccatggt taatgaagct tgtcttgggt 65101 gggcccccat tgaggtaatg cgccgttgcg ggattttggt tttccttgtt agactcattt 65161 aggtttagca aatcaatata atcattggtt gcgttattgc tgttaggacc cgtgatttgt 65221 tcgtagatcc tttgtttgtt atttgtattc accagactat tcacactaac ggtgctacca 65281 catatactgt ttgactgctg ctgaccaaat tggtacatac ttggagtgat tggtgatgat 65341 tgttccatat tccggctgaa aacgctgtta tcagagagtg agctcatgtt tctcattgga 65401 gtgtggcttt gagatgagga agcgggcgaa ggaatggatg tgctatttga attttcgaaa 65461 gagcatgatg gggttgatat ggtaagcttt ctcgaaatgt tcaagttgga tgcaatttgc 65521 agttttcttt gtagatccaa gtgatattct ttcacttgat taatgaaggg tagaacacca 65581 ttgaccgttt tatacacttc catcaaggag ttaggaatgg aaacaatgcc gttcattaag 65641 gtactcaaaa tttcaccatt tttgctttct gatgtcattg gagtcattaa aaaaggaccg 65701 tggtcttgat tggtgaattg attgataatg gagaatatgc cgtgcgatac ttcgaaaagt 65761 tcatatctaa gtaagtcgta ctgccacgcg gatacatcaa tcaagaattt tttcaaatta 65821 atcaacttga tctttagttt taagtcttct tcttcttctt cttcgttttg gtagggcctc 65881 tcgtctacag tggcatcact atcctgggat aattgagact gacgtttttc agagcattgt 65941 ttgtcataag taacttgatt ttcataaagt tcgtattgca tcaaacaatt ttcatcaaca 66001 tttaaaacgt aatcattgat cattggttca taaatgttcc aatttaaagt gtctagtata 66061 tgtctttcca tttgtaaaaa cattgattca tcaaagacct gaccatcacc acagtaatga 66121 actagttcag agagtcgagg tatacgtgcc cttgggttgg gaccataaaa tcttccgcca 66181 gtagggatga ctacattatt gatgatgtga ttacaaccgc cccaagtttt agcagccaac 66241 cagagacaag tagcgacaac caatttggct tggtcccgta acacgattct cttggaacaa 66301 tagcggtcat ataatctaac tgaatgaaaa aaaataccat ttgtcactcg agtgaccaca 66361 gacagctcga acaaaaaagt gataatgttg gaccttgttt ccacggggtt catttcaggc 66421 tgctggtcta ttagttttgg attaggtttg aacttacatg attgagcaat aacattggtg 66481 gagatttctt ggtggtattc ttgcagcatt tcgaagtgag aaagtaattc tgcattagat 66541 agctcaatcg gatagtagtc cggtttagca ttgatgacga gtcccatacg gggtcttggt 66601 tcagcactag ccattgtctg tcgttaaatt taatgaatga atggaaaaaa gaaaagattt 66661 tcttttgtat gcaaattatg atgtggtaag cgaatgaatt ggcagctata gagtctagca 66721 atgctgtata taagaagaaa atttgacgat gaagtaaagt agatgttaaa ataaaagtaa 66781 gttgtccttg atattatcta ttgccaattc actaaaaaac cagtaagagg agcataatag 66841 ttaccagagt cgattgctat ttttttatat atgaaagaga tagtaagtta aacaagtagc 66901 cagaggctgc gtgcgatacg caaatagaag gcggatctgc gttctgcgtt tgcgcaggcc 66961 ttttttcctt tccgtttttc agtaggcctg tcagatcaac atttcgcagg ttagatcctc 67021 aaaaagggcc aacagttgtt tcagttggtg ttcatttcaa tttttagcag ttatacttaa 67081 caggctacgc caaatgtgct cttcgctagg tatccgcatg cggaaacata acggtttttg 67141 gcgcgtttcg tgactagaac acgcagtttt gaggttcagc gggacgaatt tcgtgtactt 67201 ccgttgagac aaatttcgcg atgatttccg ttttcggaaa gatggagccg ggtaaagcgc 67261 gcatgaattg ataacttggc acttttgaac ctcagtatca ttattaacaa tgtatagttg 67321 ctttagttcg catttcaggg taaaagtgcg gaggatacga aaaagatgag ataacttaca 67381 gaaggaaacg aatagtggtt tcaaaaaatg cctttcactc gtagagaaaa caataaaagt 67441 taccgcactc caacacaggc gatactggag gaatattttc aagagtaaat agaagcaaag 67501 atgcttaaaa atggatactt gaaccaattt ttctgtagcg gtatattacg ctgctctttt 67561 aaaattattt ctgacgcgac ccgtttttgt gtcgctcggt gaaaatcacg aaaaacttga 67621 cactttgaaa actaatacaa cataaagaga ctgaagacga ggaaatcaaa acaacgaaaa 67681 aagtcaatct tcgaaggagc atagaggcga atgactactg aacaatgaat caggaagaca 67741 acacgggcgg agggggcatt tttggtcttt tcaaatggac taaggatgcg ctgtttggta 67801 cggacatatc accttcaatg aaatataaag atcaggaaga acgaagagac cgatctaggt 67861 atgcccaaga cgacacaaat ttttctatga agtttggaaa tgactccaac aggaggagta 67921 caaacttatc gaggtcaaat tcgtggtctg gtctggattc aacgctccat aggaagtacg 67981 agttactccc agagtacaac gagaacggct ttaactcaat tgttaacggt gaccaccaca 68041 gcaaagagag aatacgatct ttacgaagtc ctgctccgat agtaccgaga gaaccacttc 68101 gtaacgaacc tacggataca tttggtcaca gactacacac aaaaaggaga actataaatg 68161 agctttccaa ttcgcagata ccctttatac cacctcagga agacgaccct ttgctctcga 68221 aattatttaa caaggatgga gttaatgagg ttagaagatc gccctataag ttatcggtta 68281 aagatatacc aggcaaattt ccatctccct taacaaaacg tgatgaaata gacaattact 68341 atgtccggga cgaagatgct tgccacaaga atagagagta taaaaaggca tattttgatc 68401 tttttgcaca aatggacttg aacagtagag acctggaaga tttgtgtgag gatgttagag 68461 agcagcgtga gcaattccac aggaatgagc aaacttataa gcaagcatac gaggaaatga 68521 gagcagaact ggtcaacgag ttgaagaaat ctaagacact ctttgaaaat tattattcat 68581 taggtcagaa gtacaagagt ttgaaaaagg tccttgatca aacgatcagt catgaggctg 68641 aactggccac ttctagggaa cggctgtatc aggaggagga tttgaaaaac tttgaaatac 68701 aaacattgaa gcaaagacta tccgatttag agctgaaata taccaatttg caaatagaaa 68761 aggacatgca gcgggacaat tatgaatccg aaatacatga tttattatta cagcttagcc 68821 ttcgtaataa cgagagaaaa gatacttctg ctggttcgaa tattttttca acaggacaat 68881 aggacaggac tccattccac aatggaaata acagttacga ctctaattcg cattcatggg 68941 acactgatta cttaaaaaat atagacggat tcatagaacg ctgaagcaga aaagctgaca 69001 cgtttctccc actgtaacat taaaaatacg tcatgatagc aatgataatg tgttaactac 69061 ttaggtatgt acattatata gataacggaa taaaaaaaga tacgttctta ttatcatcac 69121 tcaacacgag ctgtaattcc cgcccatttt ttcttcatta tcaggttgcg attttgaaca 69181 aaaaaagtga aacttgaagt tacgatgtga cataaatttg ttaaaataaa aaagataaaa 69241 ttcaggatag aagtaggtgc aacgcgaaat tgtctctgtc tacttgtgcc ttgaacatcg 69301 aacttacaac agattaacaa agtatcgttg ctcttttcat tcgtctgttc gttatcatca 69361 ttggataggg cttactttct cgcacgtgat ttttcccaca gtataaattt tgagctataa 69421 gtggtaataa aaattcaata aaaatatagg gaaaacaagc ccagtagttt tgatttcttc 69481 tatcatgtca gctatacaat cgccagcacc taaacctctg cagccaactt atccagctgc 69541 ttcgccagct tccacgaatg catatatgaa gccgggccta attggtagtc ctgccgtcag 69601 taatcatacc gagcctaaca atggtaacaa tgaaactgcg gagcctcagg gaccaaatca 69661 gagaattgat ttgggtgcca tgatcgaaga attaacctca ctattgggaa aagaaagctg 69721 gacgaaatat gctcagatca tcagtctttt cattttaggg aagttatcca gaaaggaact 69781 ttctaatgaa ttagagctgg tattttcacc aagcgctgca agcttagaaa aatcaaatac 69841 aaatcatcac catagtttag tacgacttca taaccaactt ttattaggga tttttgctaa 69901 ttcattacgt gaaaaccctc ttgggagaaa cggtaatgag agttcttggg gatttggcaa 69961 tggaagcaac aatccaaaca ataaactaaa aagaatcaat aagcataact ctcaaattga 70021 agtctataaa aaaattgtca tgtcgttacc tctaaatgat cgaaatagac ttaaaatgat 70081 cacgaaagag gccggcaaaa gaggcttcat tttttgctct gtatttcaag ccagattaaa 70141 taatataccc aaaattccca ttgtaaccaa tccagaaagt ttgaagcgtg tcaagagcaa 70201 taatttaaaa acgccgctgg aatggtcaca agatataatg aatggattca acgttccttt 70261 agcgagcgaa agccattctt taccagacac ggattcgttt tacttaagaa tggttggtat 70321 agcaagagaa catgggttag tcggcacagt ggacgcacgt tgcgtagagc ttatatcatt 70381 ggccctagat caatatctaa aaaatataat agagtttact attgatacag ttcgttatag 70441 aaggaagaaa tattcagatt attatgattt gaatgagagt gggctttata aatccgtatc 70501 agaaatggct gctgataaac gcgatgccaa aattaagcag ttagatgatg ataaaaatga 70561 ggatgaatgt gccgatgaag ccaaaagtat taataacggc aataacagta gcaaggacga 70621 tattggcgac atatcaatga gcagcattac aaaggctggc gaagcagtta atgaggagtt 70681 acatgaaaac agaacgatat cattaacgaa tgaagacata tatgattcgt tatctatatt 70741 tccgaatttg gttgaacctt caggttcata ctatgcgtta actaatttag ggctagttaa 70801 cgatgatgaa ctagtagata tgaagagcaa tattgacgac ttgccggact tcttaaatga 70861 aaagccgact ttcacgcctt tggatgaaag aaacgttggt acaaggcatg aattaaattg 70921 gttaattaaa ggaatcttaa cggaagattg atgtataaaa agtgtgtgta tgcggtatgt 70981 tgtaattata ttgaaagatt ataaacctta tttgtttcat atctaaatgg ctgtgttaag 71041 aaagacgata atgtgaccga gcttaagtga gctttttctt tcttttacaa agttgtgttt 71101 gaacttcttc tgaaatcgtt aataatttat tgacattttt tgaatcgttc aagtttagca 71161 agaaaaagga tttagtatca gaaattagtt ttttcagaac aagtgcaata ggggtctcgc 71221 atgattcctt cttaaagatg cttttatcaa actgttcaat ggacttcaga ttatttaact 71281 cgataaaata aaagtccacc ggtacggggt cattgttgcc atcgcttttt gaatctcgag 71341 gaaaaaactg caccttgatt atacccatcc cagaatgagg taaatttggg tgttcatcac 71401 aactaaaatt taagggcaaa tcttcgagtc cattttctat gatgacaagt ttggaatcca 71461 aagaaattga gtgtttttca aatttcaact ttatgctatc tttatcattg tgggaataat 71521 ccaagagcat gtcctgagaa aattcgtcat ctgataaaaa tacaaactgt aaggtgatca 71581 catattgttt ttgatatatt gtatcctttt cggccaaaaa ttttattaga gactctctca 71641 atgagccatg tggagtggtg cttagagata ttaagttgaa attttttttt tggttcaggc 71701 acatatcatg gtaaacgcta tactcttgag tgaaaaattt atcttcagaa acttttaaat 71761 gcggtatcac cctattaaat ttgtaaacat gttcgcttag accttgggtt attacgccat 71821 tttcgtaatc aaataaaagg ttctcaggca aattttgctc catcacgtaa gcgtaacagc 71881 gcatcgtgcc tttttgttca ataatagagt tttcaagtct cctactccgc aggagttctt 71941 tttccacagt gttataggta tcattataaa atttttcctg tttagaggcc atttctttca 72001 aattttccat ttggttttgt aaatgttcca aatcttgcga gttttgtaag gatttgctta 72061 ttagtgggtt gtttgccaat tccaattgtt ttatattttc atttatttct gagatgtttt 72121 gttccgaata ttcagcttgt ctatctatat ccatgatctc cttgtgtaac ttctcacttt 72181 ccgattgtag agtggctatc tgatcaagta attcacgatg tttgtttgtc aaattttcca 72241 tggattttaa cttagcttct ttgaatgcaa taaaatcctt cctcaattgt gattcgtggt 72301 ttacttgtct ttccaagttt tgcttctgta aattcgccca atttatgttg agctcttgca 72361 gcgttttctt caactgagat atttcctctg tgatttcgtg gtcaggctcg acattttcca 72421 ttatttgcag ctcattttcc caaaagataa gcttattatt gtacaattct tgagattcct 72481 gccttttcaa gatcagattc tggtcgagtt cagcctgcaa ggttgccaaa gcggatttgt 72541 tcttcttaat taaatcagcg cgttcaccgt ccttggagtt cagattttgc gtcaaatctc 72601 taacctgttt gagatacttt gcttgtttgg attttttctt ataaagttca aacctggact 72661 tattgagatc tcgaaacttg atggttttga tttctctttc gcactcaatc aattgagtcc 72721 tgagagtatg tctttggaac cttattttgt cttggcggtc ttttaagtcc ttaattttgc 72781 tcatgttgat gtttaatgat gcagatcgag atacagatgg gaaggaatcc tttacgggtg 72841 gaagagccaa tgaactcttc atagacgaag gtctagagcc attcatggtg tttgtcgtgt 72901 ttgtgatatc cataaggttt cgagattttg atgaggacac attatcggga ttgtgaaaga 72961 ttctattctt tgaaagaaaa gcgtgtttgt tttgctgtga cgccataaag tacactggtc 73021 aggaaatggt gcttttgcga ggagaatgtg tgtgtatgtg tgtgttgtta gggcatttca 73081 tattctatat tcattgtttt tttgtttttt ttgttttttc agttctttgt ttacctattt 73141 tttctttgcc gcaattgcaa atattattaa cttaattgcg attattgaga ctaaacaata 73201 aagacctggc agtggaggca tgacagagga tatcgcgaaa cgattgttta agagtatatt 73261 ataaagttga cttgtttcct tataattata attataaata tatatatata gattattcac 73321 aggagaaatt gggggcacaa atgaggggta aaaatgcaga cattaactaa aatcgttgtt 73381 attaacgttt cttgtcatct ggggcagagc gactctaatc ccatcgatat cttttgacat 73441 cttaatctgg cacccaagcc tgcttgtctc tgttagcccg taagcaagat cgagcatatc 73501 gttttcatca tcttcaggtt ccggcagggc atcgtagtag tctggatcaa cgatgacgtg 73561 acaggtggag caggcacaag aaccgccgca tgcgccctcc atgtccaggt tgtgaccttg 73621 agcgatgtcc aggatggttt cgccctcaca gacttcgtac gtcttctggg agccatcctt 73681 cagaataaaa gttatcttca gttcttcgcc tggtttcggt tttttcaaat ggccatggtt 73741 taagaacgaa gacgtagaga agggcagaaa tcttgtggtt gtggtggtgc gtgtgagcag 73801 agatggagag gtgcgtaaaa gatgtgctgc gatgttcgat attctagctg tgtgtccagc 73861 ccgagtaaca attttcagca ttgggggcgg gttgagtata gatacgagaa gcgcctattt 73921 cgtatgaggt tttttttttc tattattatg tatattaggc atatatatac atatatatat 73981 tttgcataca tattcatttt taaaaaaatg caactgctac acgctttgaa agattcaatg 74041 aaaagttttt ccgacgacca gaattggcta gcaaaaaaac gaaaatgtaa tggagtcatg 74101 caaacatgac taatagtaac aaaaaaaaaa gatatagtag aattgagtaa gtaagttcta 74161 tgtatattgt tgttattttc tctaaaaaaa aaaaaaaact atgtaaaatt aggaattaag 74221 aatatgcttg gaaggaatgc cgatttaaaa tgtgtaggat atgcgatgca aggggtcgtg 74281 agaacaagta gagatgtggt aaaatgcgtc ataccgatga caaccacagt ctgtagttct 74341 gttgtgcgac attggcaaag gcatcgttac ttgcaaaggc aaacccagag gcagagttag 74401 attccttact agcagcagca actgcactgg cggcgttgcc gttaaattcc atatcgaaca 74461 tgcaatcgtc ttcagtactc gttattatgt tgctgtccgt cttatcttta gtgtgcgtgc 74521 attctgactc atcgacaatc gggtacgata gcggaaaagt tagcaattct tgctggtaag 74581 attgagaaaa gtcatcggca taagtcgatc tgtccgggct atgcgagagc atagggggct 74641 cgaaagcaac gtttgaaaac gaaagaggga agacctcgtc ttcatagcgc gagatggggg 74701 aagattccac agaggacatt gtaaataatt gtaattgtat attattgtgt gtaagtttgg 74761 ttggtttggt gtagccaatt tagtttggtt ttctcaagaa taaaacaagt aagaaagaaa 74821 gagagttgct ccagaccctt tccgaaatca agatgagtcc tgttcttata tatacctttt 74881 tacgcagagc cgcttcttta tgcaccgtgg agtaattacc gaattgcaaa accacccggg 74941 tgtggatgtg gatgcaaaat aacagtgaaa tgagtaataa caatggtcat aaacatgtgg 75001 tgtgcaatgt gtcatcttcg cgcgcgtgct aaaaaaaacg aataacggtg gtgatcccgc 75061 ggctttccac actgacgggg tcacgtgtgt ttattctgtt ttcttctaac ggcttctgta 75121 gatttccgga cggttccacg cagcgccaca gcttggttcc agatcgacgg aagagaacgt 75181 gcaacccttt gggctggtta tgaaacaacg cagatggaga atatggctca caaccccaag 75241 ggacttcttg gtttggtttt gtttacagtt ttttgcttgg caaaggtgcc atcgtttgtc 75301 atgatagcat gacggtagca ggcatcattg attttgcaac tgttgcggac caggacagtg 75361 ggtatggtgt aacttctgta acacacccac aaatgtggtt gagtctctaa tggagatgag 75421 tgagtgggcg agccaggata gggtctttgg catgtgcggt gcttacccgg aagggagatg 75481 cgcacgtgac tgttgaaaaa gggaaaagca gaggtaatga atgacgaagt cggttcattg 75541 catgtgctgt tacacttctt aaatagatat cgattaagaa ttactataat gatttgttac 75601 ttatttttta ttaactagct ttgggggaga gccatggaaa atagcactcg gtcttgtggc 75661 ggagttggat ttgcttgact gtggccccct cacgctgttt aatgacgacg agaggcagca 75721 atgatgttgt tcatttcttc gaccttagcc ttggctctgg tgaaagaacc caatctcttc 75781 ttggcgacct ttctggctct cttttcaccg gagtttctga tcaaatcgat caatcttctt 75841 tcatatgggg acaaaccggc gatttctcta accaaagatc tgacgaactt ggttctgttg 75901 gaggcagcac ccttcttgta ggagatcttt ggggctggag tcatttgggt gactttctta 75961 cccttgttca aaccaatagc gatacctaga ggaaaaaaat agaatatctt atgttagtaa 76021 caagcacact agtactcacg tagtatacga gcaaaataaa taaacaaaga ctccacggag 76081 tactgcaacg ctgggtgcag gatataaacg atgtttgcat atctctggag cttaatctca 76141 tcctgtttgt atttctgttg ttggcttagt ggttcagttc attttgcttt tgctctacag 76201 ttcattagtt caggtaaaca taccagtctt gacagccatt ttgtattatc cttgcttctc 76261 tattctgttt tgactatggt aatacacgaa cttaagactt aacgctaatt aaaacgaata 76321 ttcaagaaat gcaatgatgt gcctcttcct ctgcctctct ctctctctct ctcctagtgc 76381 attcatgcta gcttccctcg tcgggcttcc ctgaacagcc ttggttggca acccaatgaa 76441 aaagttccgc gcacgcggta tgtgcgtctt tcgcaaccag acctctcggt catggtcgtc 76501 tcccgcacgg taaagcggaa acaaaaaccc aacacatccg tggatgtacg ggtgaaaata 76561 cagtcaaaaa aaaaacaaca acaacaacat tgtctaaacg agtcgtgatg cattttttaa 76621 cacaaattgg agaggcacac aatgtgcaca cagcgcaaaa ctatacatct atttaaaaac 76681 ttttttaaaa ccagtccagc ctttcctccc tttagcctta gaatctcgtt ccaataacga 76741 tgccgtggac acttgctcct tattgatgtt aatcaactca tcgatttccg cttgcagttc 76801 agtgattctt tcctctaatt ggccgttctc cctcatcacc tcattgttcc tggatatggt 76861 cctttccaag tcttctctca gatctgcctt tggtagtgac gcgtccgggt tcggtaaatt 76921 ttgcttgcga atctcttcct caatttggct tttgatatca gtgattgtat ttatcaggtc 76981 gtttttttca tccaacagca tctccatatt caatctgttc tgaatcagct cgttagcggc 77041 gctgatattc tctttgttca aaattgaata gtcgtgttct agcttctgcg cctctctttg 77101 tagttggtgg ttttgaattc ttagtgattc gtagtggtcc tctttttttt gctctttttc 77161 atggatttct acgtactctc ccctgtatct tcttaatgtt aatggtgtga tatatacacc 77221 tgtcattgca tcatgaacga aaagatcgac attgtaggaa aaagtgccgt catcattgcc 77281 cttaaatgag ttcccatttg acaatcccat ttgcactaca gaagcgtcat cctggtttcc 77341 cattaaatag taattgaaga gttcgtcctt taaaaaatcc aatagttcat cgaatctcaa 77401 ttttactaaa gtttcttcat tctttaacat taaatttaca gcaaacttca aaagcacttc 77461 aataccctct acgaatacaa tatcaaaaat tcttaacaca aactctaacg gaaacttgta 77521 tgcgaaaaat gtcaaaaacc attgtgtagc gtacattgtg gagctaattc cctcacggat 77581 caagcgattg tacaaagaag gtgaatgctc ctctaataat ctatcaaatt gataaagcat 77641 taacatcagc ccaggcattc ctggtaagaa aagctctctt aatccataat tcttcattaa 77701 tccaacgagt agtccaaaag attcggcctc gttttcacag tttattaata gcggcgctgc 77761 aatgaacccc atgccttgcg tgtacccaac atctggatca taaacagaat acacctttat 77821 taccttgtat agtgactcca ttttgtcctc ggccacaaac ttcgttctcc ttaaatctct 77881 acgtattgtt gcttcatgaa gacattcggt atccaataga gtttcatata tatcttccat 77941 ttctcttgat ttggaattcg ccatcagctg ccaaatgata cctcgaattt gtggtggtat 78001 cccattggta acatgggctt ctaaattttc tggttcgttg cttgccactg tagcataatc 78061 attaactact tgagtccaga aggaccaatc aattttaaac atttctctat cttcttcatt 78121 aacattctcc acttcgttat actcggacaa gttctccaga aatgacgtaa atgtcgattt 78181 taaaaagctt tgaccttcct gcaacgactc tctagtttct tccccctctt tattcaaatg 78241 gtgactggtc ttgcggtaac gactagcgat caaattaatt tctgcagtgg actctaattg 78301 cgcagttttg gaaccagtga gaggaacatg atgataacta tttcttttag tttcttcgaa 78361 gtttttacgg aacttctctg acttcatttc ttcctctagt ggcggtggaa cagcattctt 78421 cgtcttcggt ggttgttccc tttgtttgcc ccttggaggt aattttggtg acgttgatgt 78481 cgcaacattt tgtctaggtg gtaatggtgg cgaagatgta gtgggaattg cggaaacctc 78541 gttctcgctt gagttatcac ctttttcatt tatgatttgt gtgggtatag gtggtacttt 78601 cctagcagtt tctgaggaaa gattctctgc tgttacgggc ccatcttcta tagcagcttt 78661 ttgttccttg ttttcattca agtttattcc tgcggctacc tcattggtaa tatgaatctg 78721 gttattatca ttttctgacg acctttctgg ggttacttca ctacttatag aaatgtcgtt 78781 cgcatttgca gctgtcgtag taccagattc gtcatcgaga aatttactcg aggatgattt 78841 ctcacctcca gaattttttc cagttacttc cctattttct ggactactaa caacctcttt 78901 cgtatcagcg taaaccttct cattctcttt gactgcatca tattcttttt caatattcag 78961 cccatttggg gcttgcacat ccgttgtcac atctttttca acatccaatg gctcatttaa 79021 atcaatttca gaactaggtt ctctcgtttc ttgcctttgt tcattaacgt tttgttcagt 79081 gatttgggtg tcttcatcac cagagatccc aataggttct tctcttgata catttgtggg 79141 tgcttcatgg cctaaacttt gttgcttgtc atttagttct ttgtccgaat ggaggggctc 79201 agttggaatt atagctatct cttcatattg gtctgatggc gttgatttta tctcttcctc 79261 cattgaaccc aaattattcg aatgattatc accttcgtga acttcagagg cgatcgtatc 79321 tgtatttttc tcaatagatt tgtctgaaga cattgctcta ttaacgttct actttacact 79381 ggtggtagga gctgttttat tttgagtatt aactaatcaa tctcaattac gttcgatcca 79441 aacccttttt tttcgttata tgagcgaagc ttctgaataa gccctcgtaa tatattttca 79501 tgaagaattt aggtccaaaa aaaagatggg cattaattct agtcatttaa aaaattctat 79561 agatcagagg ttacatggcc aagattgaaa cttagaggag tatagttaca taaaagaagg 79621 caaaacgatg tataaatgaa agaaattgag atggtgcacg atgcacagtt gaagtgaact 79681 tgcggggttt ttcagtatct acgattcatt ttactctttt tttgggtttg gtggggtatc 79741 ttcatcatcg aatagatagt tatatacatc atccattgta gtggtattaa acatccctgt 79801 agtgattcca aacgcgttat acgcagtttg gtccgtccaa ccaggtgaca gtggttttga 79861 attattacca tcatcaattt tactagccgt gatttcatta ttcatgaagt tatcatgaac 79921 gttagaggag gcaattggtt gtgaaagcgc ttgagaattt gtttgagttg ttatgaggtt 79981 cggaccgttg ctactgttag tgaaagtgaa ggacaatgag ctatcagcaa tattcccact 80041 ttgattaaaa ttggcgccac caaacaaagc agacggggtc agtggcacta atgattgcag 80101 ctgttgctgt tgccctagaa aaggcgtgac tgagcgatgc gaaggtgtgc ttcttggtat 80161 tgtcactgga gagttacgag agggtggacg gttagataac agcttgacta gatcactgaa 80221 acttgctcct gatttcaatg gcacaggtga aggccctact gagccaggag aaacatattt 80281 aacactgata ttgttgacat tttcctccgg aagagtaggg tattgggcga tagttgcaga 80341 accgacaata tttttaatgg cgctaccatt actattgtta taactgatat gcggtaatgg 80401 gattgcacac tgtgataaca gaaacggcgc acatacctct tccagtactt gaatgtattt 80461 ttcacaagtc tggattttaa aagtggccag tttttttaat agcatcagaa cagtgttaat 80521 ttgttgtaat aattgtgcgg tctcgttatt ctcagcattc gattttgagt ttgagagtag 80581 agtctttatg ggtactagga ctgcattgaa caagtaataa gaacaattcc aggcaaaata 80641 tggggtgaca ttatgattgt ccatatagct acttacagac ataacagttc tttgtgctgc 80701 atcgcttaac atgatggagc atcgtttaac ttcataactt tgatgatcat tttgatcctg 80761 ttctagttgt gactttttct gggtaaaatt agtgaaaaaa tctcttaata cataaatgat 80821 aagagacaac tgtttccact tcagttcgaa tcttgtaaag gatagccaag ggtgttcctt 80881 caacaaattg gttagagcgg tggtggaaat atccatttgt aaaaactttg gtgcctgtct 80941 cgaaacctcc tcaatctcat tacaaatcat caagcatttt tttgcacata taggactttt 81001 ttctgcagtt actgttttgt ctagttcata gatttttgtg aaaacttgta agagccttgc 81061 tgtttcaatg atgccatgat atatggtggg acctgttgtg gtacgctgca catcgtcgac 81121 agaagaaggg aaggagattg tattctgaga aagctggatg gatcgaccat aaagcaggga 81181 caattggatc tcccaagagt agacagacca ccaaattcgg cgtctttgtt ccagaatgct 81241 gctatcactg aaggacgagg ggaggtccct attcaagccc aatgatatgg ccattcttat 81301 ggaaaagctg tgaaaattat agctagtatt tgttttctgc ctccactgtg tatatcgcga 81361 cagaagatgt agggctgtca ccaaaattat ggaacctgac tcgaagacct tgctcgtcaa 81421 atgagattta gcattttgat agtaaaaaac atctatatca gtagattccc cctctataca 81481 ccaggctcca atggctaata tgcagttaaa aaggatttgc cattgatcct tcgacgcgat 81541 ttcaatctgg ttattataca acatcattag cgtcggtgag tgcacgatag ggcagtaggg 81601 gtgaaaatta ttgagataac tttgaagtaa acgggatgtt gtggatctag aagccaacgt 81661 gtatctatcc gtaatcatgg tcgggagcct gttaacgtta gagttcgtgt aattttccgg 81721 tttaaagcca atagatcgaa gaatacataa gagagaaccg tcgccaaaga acccattatt 81781 gttggggtcc gttttcagga agggcaagcc atccgacatg tcatcctctt cagaccaatc 81841 aaatccatga agagcatccc tgggcataaa atccaacgga attgtggagt tatcatgatg 81901 agctgccgag tcaatcgata cagtcaactg tctttgacct ttgttactac tctcttccga 81961 tgatgatgtc gcacttattc tatgctgtct caatgttaga ggcatatcag tctccactga 82021 agccaatcta tctgtgacgg catctttatt cacattatct tgtacaaata atcctgttaa 82081 caatgctttt atatcctgta aagaatccat tttcaaaatc atgtcaaggt cttctcgagg 82141 aaaaatcagt agaaatagct gttccagtct ttctagcctt gattccactt ctgtcagatg 82201 tgccctagtc agcggagacc ttttggtttt gggagagtag cgacactccc agttgttctt 82261 cagacacttg gcgcacttcg gtttttcttt ggagcacttg agctttttaa gtcggcaaat 82321 atcgcatgct tgttcgatag aagacagtag cttcatcttt caggaggctt gcttctctgt 82381 cctctcttaa aatgatggcg tgcattacgt agacacaatc tggagatgaa gctgaaaatc 82441 tggggaagga tgacggaaaa aatagctcat aaaacagaaa aaggcccgaa gtaacaatag 82501 gaaaaattaa ttgcactaaa caaagaaaac gatattatgg tgattaaact gatacagaat 82561 tatgtaaata ctttgaaatt atagaaggtt tgtagaataa aaaaaatact gggcgaatgc 82621 tgtctcaaag gacgcggacg ttttgaaact tcttgccgct cacgcaccca aaccaatcgc 82681 ccctctgggg cctccatgca atgttgttta tctcttgtgt tttattggca tacatcatgt 82741 taggagtctc tagtgtcttg cacacctgct tgctgttgtt gtttaaactt aagggatcct 82801 cgtttaaacc ggatcctgcg ccaccgtctg tcatctctgt gtcgccgtca gggtcctcca 82861 aggaagttcc atgaatactg ggggatttgc tacctgcagc gttaatttcc ataaaggagc 82921 tgttcaagtc ccaatagagc acctggcagt catctccgca cgagagcaaa acattgcgct 82981 ttgtgggatg ccatttaatc ccgtttaccg aagaaccgtg gccttgtaag tttagtatag 83041 gggattctgg gttcctcata tctagaataa tgattttgtt cgagtcagct gcaaaagtgg 83101 ccaacacatt tgggtcatac ggtgatggct ccagcctcaa taaggcgtcc gaacctttcg 83161 acgacggtgt tatagtaccc gcagtggctc cagacactga ggaagaggga ggctcgtaaa 83221 taattgtact gtgcgcaagc gatcttaaat caaatactcg tacactaccg tccccaccac 83281 aactagcaaa taattgggtc gattttgtca aaaaccttac atcaaaaact tcgctgtcgt 83341 gagcgatcaa ttgggtctta acgtagtgac tgctttgcag atcccataca atgcatgtgg 83401 tgtcgatgga acttgagatt atcaagttag tatcgaccgt gttccagtca aatgatgtta 83461 ttggtgggaa agtgcctatg accttcatgt catctgcggc cgcgggattg gcggggtgct 83521 gtctattgta tttacacaga gatagattta tttgttcttg gaactgtctt tcctcagggc 83581 taacgctcca aatccgtaag gagtcagaac acgtcgcgag tttccttgga tacaattgag 83641 aggggaccca ttggattttg ctcacaggat aaaccacatc tgcgtccact acgctttccc 83701 agctcagtag atcattagag tgcagaacct gcaacttatt tctgctgtcc tctttgtacg 83761 aacccaagca gacgtagtcg tcggcgctcc aatcgagccc aaagagtgga tagtgtgatt 83821 gatattcgca cacggaggcc atggaagggt tcatcagatt gcttacaacc ggaatatttg 83881 cagcatagcc cctcgcctgc tgtaactgag aatgatttgg tgaaaaaact ggtggcgaga 83941 aatctaacgg tgaatacatc ggcgatcgac ttgcatagta cgtggcactt aggtcacagc 84001 cactattcct tttgctgtta ccgccattgg tagtgttgcc agacattcca aagggagatg 84061 ggcctctacc ttgatcttgt gccgccgagg aaggcccatt agtaccactc aagtaattgt 84121 tcttgttata tggctgccgc tgcgatgagc caaacgatat tgagctcctt ttattgccat 84181 tgtgaaaggg atccatttga agggcgtgta tttgctccta taattccttt ccttcttgtt 84241 gtctgttgac cctttaggtt gtatgccact ctcgaaaacc taaagaactg attactaaat 84301 tatttataca agatttcaga tgacaagatg gttcacccct tgcccctggt cttcctccca 84361 gtaattattc atattccatt ttttttcata aacgcacgct aaggaaaaag aagagactga 84421 aaattcttgc atattagaat ataaaatgat atatactaca tttatataca tccttaaact 84481 gtgaaagaaa gaatagcgat acaaatgtct aggcagtccc taggacagtg ccggagttgt 84541 cattgtggag aggcaatggt gtttctgtgg acattaacgg ttcgtaatct ttagttctgt 84601 cgatatcctc atctctgtaa tacttaattc cccaaggtat taatcgaatt aaaccgtcta 84661 aacttttttc gattttggtg atgatccatc ctggtggagt gatcttgtta aaccacgatt 84721 ccttgtagcc tatggcgtaa ccgacacata agccgaaaaa atgaccccag aaactggagc 84781 caggtataac gacggcaatt gcgactaata gtactagggg tgtatataat gtcggaattg 84841 agtagtctgt gcgaaagatc cttgttctag ggcggatctg tgattcttta aaactatagt 84901 atgcgaataa ggtgaaacac cacccactgg cgcctgcaac taatgcttct ggatatagca 84961 acttacccaa caaacagtac agaattccgg caaatagagc actcaggttc aaaaaaacac 85021 ctgtgtacac agtcccatgc gtttcttcga agagattcaa gggtgcccag atggctagca 85081 cattgaacag taaatgaggc aatgataggt gaattaaagg ataaagcgat agcctgctca 85141 tttgcagttt gaacaatgac tctggcgcca acgacaggtc ttcccttagg gcaaaaataa 85201 aacttaacag gtaaatagcg gttagaaata ccacaaggcc tgtggtcaac gcagctggtg 85261 gatgaccacc gggaaaaacg tacgacttcc aattcatagc acgaccaaat agcacaacct 85321 aacaaccaga gtgaattgct gttctcagtg cttccaatta agcctttccc atccccctat 85381 tcttcttgta tcgatgcagt tcaaaaaaaa aaaaaaaaag aggctttaga tctcaaaggg 85441 ccgaaaaaag tgaaaaattt tctcgagaaa tcataaaagc agccatcgcc atatataaac 85501 aatctatgca tatgtatgca gcatggcatc gcatctttct tggcgacccg gtagtagcat 85561 ttaacttcca ttagaaccat ataaaatgca tgggcctact tcaaaagcta tttcccgcaa 85621 tgtgagaagc gtgaagagac caagaagagc acctaggccc gtggtctcca cgcaggctat 85681 gaacaagttg tctaacgtaa cactctctgc tgaacaagaa aagttgagag agcgcgtttt 85741 gtcgttcatg cgttccaact tatctcagta caagtctgac tggaaacatc cggccatgtt 85801 tgtaatccaa ggggacgcag gtacaggcaa gtctgtgatt ctaaactcct tgttcaatga 85861 aattcagaaa ctatcccagt tctcaccttc ttctgaagat atcttacatg ggacacataa 85921 ttatctggta gtcaaccatc ccgagatgtt aaagttatat atccggatta gtgacagttt 85981 caaatatatt tctaaatcgt cactagaacg gcccacttcg ttgatcaaca atctacagaa 86041 gagaaaagtc atggccgatg tagtcattgt agatgaagca catttgttgg ccacttctaa 86101 ggatgctttc aaaagatttt atggcgaaaa ccatctcaaa gacttaatgt ccctttgtaa 86161 agtgcttgta ttggtttacg atgataagca agctttaaga atgggttcct attgggatga 86221 aggttctaat aacggtgcca ctttaaagga cttttacaac gagattccac caaaatccag 86281 agactggtac actttaaaac agcagtttag ggttgctgcc ccacaaaacg tgttgaactg 86341 gattgaccaa attagtgtcg caggtaaaat cccaccaatt gaatctgtgc tatctaaggg 86401 caatgcagat tgtgctgacg ataaaattaa gaattttgat ttcaaaattt gggatgattg 86461 tggcgccatg tacgaggcaa tcaaggagaa agaccgtcaa tacggccaat gtaggatgct 86521 atctacttac gattttccct atcgcttgga cggaaaagac tattacgttg aatgtggtga 86581 caatttcaaa gttcgctggg atcgctatac tccacgtgaa gtgacgcctt ggagtgagcg 86641 ttgcgacacg attgatgagg taggtagtgt gtatactatc caagggtttg atctgaatta 86701 tgctggtgta attttgggcc gttccattgg gtatgatgcg gctaatgact gcatcaaact 86761 aagaccagag ctgtatgacg atagggccgg tttcaccaaa aagaaaaaca ttcacaatgc 86821 agaggacgtt aagcaaaaga ttattatgaa tagcattaat gtcctcttaa ctcgtggcgt 86881 gcgtggtctg tatgtttatg catacgatcc tgaattaaga gagagactgc ttcgtccatc 86941 aaaaaaatag gaagtacata gtatagacaa attttataaa tattaacttt tatttgttgc 87001 gatcttcact aatctacgca gattttgcct tcggtatatt agccttcttc ttgttgagtg 87061 cttcccaagt gattccacca aatactataa acatccccac ccattgctgg aaacgtacac 87121 tcttaccgaa gacaataata ctcaaaatca tcgagaccat tttcctggtg actgttatca 87181 tgatcaaaac taaagagcca aattgttcta gagtatagaa aataaagcat tgtcccatag 87241 cgccacagaa cgaataaagc attaaatagc cccacacttg tgggtccatc gtcaatacag 87301 aaacggcatt atcccattgt ttgcagtcga tcacaataaa atacaaaata ttccacaata 87361 tcacgaagag gttcagtgta aacatcaagt gtgcacctgt tatcaaagtt tgttttccct 87421 tttctttggc cttattggcc tttagtagct tatcttgggt ggcgttggtc aatccatcaa 87481 ggaataaact agagaaaagt agtccaaacc cttgtaattt gttatcattt ccgctctcat 87541 taaaggatct cttcaacttt ttaccatcgt tgccacctat agtgaaaata gtgacaccga 87601 gacttaccaa gagagctaca actttttttt ggcttgctat gggcgtccta tacaaaagca 87661 aatgcaccaa caacacgggg atcatcttgc atgactttgc taacatgtaa gtgagataat 87721 ccacgtgctt taaagaagtt gtagccagcg ggcctgaact actctgtgta aatgatatca 87781 acatcaattg tttccaatga tctttaatca tttttctggg cggatattcc accttcttcc 87841 agtttaagta caggtagccc atcatcattg ccacagaagc ttgtatgagg gatattacat 87901 tagggaattg aaactttccc atggagtttg gccaggttct tgtagccaaa ggctcctgta 87961 ctaatgccca cgtcaaaaaa gtagcatata taccaatcgc acagatcacc aaactggatg 88021 tacttcccgc catacaaata tacgaatact gccttgttta cttcttcttg ttacgttgta 88081 attctggttc taattacatt gctgtcattt tttcatgttc gatgggatct acaaaacaac 88141 ctttagaagc gatctcaggg aagctttgga agagaaacag ctgatgattc tggcattcca 88201 caaactacaa caacgaacca aacgacatat tccattgcag tgatttgatt gggagtaagc 88261 ttttataaac gagcagacca atatgattta cgtagtattt cgttgtcttt accacatcgt 88321 tgttcgtgat aagttctgaa aatttttttt ggagtatatt tgctagagtt aatccaacaa 88381 tattagcata aacgagcagc tggagactag gttatttgaa ttatttgagc atcaaagtga 88441 tcaattgtat tatattacag tgtaattttc tttttttcca tattgaatca aaaactagcc 88501 acgcttgaaa ctaaagatgg ttgcctattc tccaatcatt gccacctatg gtaatcgtgc 88561 agaacagttt ttagaaacag actcagactt cgctaagtat catgcgaaat tgaataaaaa 88621 gttgcaacac ttgaggagcc gttgccattt ggtcaccaag gatacaaaga aatactcaag 88681 taaaaataag tatggcgaaa ttaactccga ggattatgat aataaaacta aattgattgg 88741 tgttttgatt ttactacacg ctgaaaggga cttggcactg gctgaaactt tgaaattgag 88801 agctcgtcaa agaggaaagt taaagaaaag tgaagaaaag gttttatcca caagattgaa 88861 gaaggcctgc aagactgctg ataaattggt taacgtcact caaaatgaac agcaatggat 88921 aactcgtgcc caatatttag cgttcgctaa attggtacat tcagagtacc taattaatgg 88981 aaaaaggttc aagaggaagg acaatgccaa aatttcgaac aacctagccc tcgttttcgc 89041 cgcattggaa cacttgaaga atctaagctt attagctgaa gaagttgtag ataacattgt 89101 taataaatac cagtactctc tcaagcagta cgcgggaaat ttaattacaa cgcccgaaat 89161 aaataacttt atcgtggaaa gagttcaatc tgatgagaac aaggacgatg agcttgtgaa 89221 attgttatta gacaatggat tcaatatgaa aaaaattaca acctcaactg aagatcaaaa 89281 ggttaccact aacataaact ggagatcttt caacgccaag ataatcgatg ctgaagttgc 89341 tcaatttttg gaacaaggtc tatctatcca cccaactcag attactcaat atacacagag 89401 gctatcaaaa ttggagaaag ctttagaccg tcatgaattt ttcatcgcaa accacgacga 89461 tcaagatgac atagacgaga tggttgaaaa tagttctgaa aacaatcaga taattttagc 89521 ctacattaaa tataatattc ttttgacctc tatatctcgt gaaagagatt tgtttactca 89581 tttatggaat caatggctga aattaaatac ttcattacca tcgaagttaa ccaaatataa 89641 agaaatggaa cgtattgtga agaatttgac aaaatattta tcggacataa tggagctacc 89701 tggtgtgtat tcagatgacg agctgctaag ccaattagac ttatgcaagc tgtatttcca 89761 gttatttctg aatacgggct gcctgagtgt tttatatcag tcgaaaggca gatatatgga 89821 ggcgttagct ctatatgtgg acgcttaccg aagattagaa aacaaattat ctgaaattga 89881 atctctagac gaaatcttac ttccagcaaa tcttttgtca ttgaattctg tccgaagctt 89941 acaaaagaga atcgaaaacg gtggtaatag tgtcattact ttggcggaat acgaaaaaag 90001 aaatcatggt ggcagcttag ggaaatatga tttgacagtg attgaaaaat tggatagtaa 90061 aaaaatactg ccaacggaca tacaattgaa aaatttattc cctctcaagc caaaaatgct 90121 gcccattcct agtaaaccaa cactttttga tttggccttc aactacataa catatgataa 90181 gcaagagccc tcagcttctc aagtgaaaga ttcagtcaca gaaaccgaga gcatctctca 90241 aacaccaatt tctaatgagc agacggaagg agagcctaaa aagaagcgtg gtttcttggg 90301 cctatttggt cgttaatatt tttctagtat gactgtattt atagtactat atagattatt 90361 ccatttaaac aaatgatgat tgccaactat agtagccaaa taacgaagtg cattacttaa 90421 cacatcttat ttttatctac tgaagatatc gccaaattac agcacatgct aaaaagaaga 90481 tgtttagggt cctttacata actatacgtt aaattatttt tgctgctgaa aataaggaaa 90541 ataaaaacaa agataaaaat agaaagaatg ggaaaattta gtaacagctt ttgcccaata 90601 tgctcaaaac cgagttatct attacaaagc gttcctttta tagaaaaaac tgacaatcaa 90661 atgtagtaat tggctattgt taacaacaac gttggaatgg aataatttcc acgtctcgat 90721 ttttggttca acttgagtct ttatcaagtc tttaaatgag aaagaatcga catcatccga 90781 gtatcgttta tcgggccctt ttcttttgtc aatcatttga ataccgaatc tagaaccatc 90841 cgatgtggaa attttgaata ttatatctgg gaatttagga ccgctcgaac caaagacttt 90901 tacagtcagt tcagctagtt tttcacccct gatggtttta agcactcctc tttcatacaa 90961 ctgctttgtg ttccatttaa acttcattcc ctgcaattca gaacgttctc ttccttgaac 91021 tttttttact gcattcttaa aatttccaaa tttacttttg tgcaccggcg aaaaatcctt 91081 ggctttctgg aagtctttta tcgtatgatc aacatgtttt ttaagccttg ataattctat 91141 atctaagctg tggttcattt ccgaaatttt tgtgagtgtt tcctttgtga tgtaaatttc 91201 ctgggttaca taatcaatgg catagttggg atttttaata gtgttcgcaa tatcgtttaa 91261 gaaattttgt aacttattat cagaagagca aaaagtcccc gtactttcta gttcatgtat 91321 ttttttcaaa gtaacatttt tgagtgtgaa gtatttcaat ggtttcagct tctgtatcat 91381 tggatcatcc ctgattttag gattttgctc cagaaaattt gcaaaatttg gttcatcttg 91441 aggtagaatt gtactaattg aaaggtcata caaattggta tctacatcct caatttgcat 91501 catgtacaca aatgcccttt taacttggtc gtagattttt ctcatcttgt catcactaac 91561 gaggaatcga tatgcagatg catccaattc caaggtaaca cgtcctgatc ttggaaagga 91621 tgaattgtcc aagttctttt ccaaaatatc atgcaaaata tctgcttccg gaaattcatt 91681 taaatactct tcaaatttac cactgatttc cagaaccttt tcagttaaca attccaattt 91741 ggggcttggc gataccatat ccaaataaat caatctatct ccctcttgtt catactctgg 91801 atctactaac acattataaa ggacatcttt gatatgaggc tttatttcgt tagcgtactg 91861 gttcaatgga tccaaaaagc catcaaaatt tttgatttca aaaacagtcg ccaaggattt 91921 cattagaatg tcaatttttt ggttattttt ttgaacgttg ctgtctttgt atccgtaata 91981 ttcccggttg accaaatatt cagacacaaa aacgttcact agaatacttg atatggccct 92041 taaagagtca atctcctcaa tattcttatc tgccgcgtag cagaagattt tagtgcagag 92101 gtacctgatt tcaacgggaa tagtgtgaac ctttctggta taaatttcag cgaccatttc 92161 aatcgcgtgc cataggcacc ttaaattgtc aatgaactta ttcttggtac tcgcatcatc 92221 cacaggcgaa caatgctgag gagagctaaa gccgtgtatt tcttgataaa ttttgtatgg 92281 atcactttca aaatccacta ctggatctga caagtaatcc aaaactggga ctattataga 92341 gaagaattct ggagactctc ttctcaaaaa atcttgaaga atggtttgcc aaaattgtga 92401 tcggttgtca agaaagcttt caatactcgg tgcttcatta atcgcatttt gtaacatttc 92461 acaaacaaac cttgtgaaat aggatctctc tctgtcgttc atcctttgat tcactgttcc 92521 aaatgtcata taaacattct ttgcaacaaa ttctggctct ttcaaataca gcaatttcca 92581 ataagaggga tcaacttgca acatatagaa cagtttttca tacttttgat atttagactt 92641 cggaatcgta gaatcggaaa taccgagttc atgatcttta tcttttaata gtccaaactt 92701 atccaatact ccgttaatat ttagttgttg tcttatgctc ttcagtaatc gttccttctt 92761 catattttcg gaatcaagag aggcttggca actctccaac tggttttgga cctcttcaat 92821 ggttgctgtt ccattgagca aatgaacgaa ttttttgaca gcccaaagac ttggatttgg 92881 acagtctaga agttccaaat atgccgatct ttgcagactt ttcctaatcc agctttgaat 92941 cataataacc gaccttacgt ttctcttgta aaaactcgac ttttggtcca agctttcacg 93001 tactaaagcg cctctagaaa atgcttgaaa taatgctaaa ttattatact ccacaatgtc 93061 atcgactaag tctaatgtgt agcggactag aatacctcta accaaaccct ggaggtcgtg 93121 cacagtttca ctgagattat tttcgggcgc aaacagtgac tgtaccttat gtcttacagc 93181 gtttccgcgt atacaggctg ataattgaat aatattacag ttttcttttc caagtgaata 93241 tattattgat gctaggcacg aacgcgtaaa tattcctcta atcaagcttt gcaattttga 93301 gatattttcc ttatgtacat catgtacagc acttaatatc gcgtcctctg aacacctcac 93361 aacgttacct ctgatgattg ccgaaaactt cataatactt tctcgctcat cgttcaactt 93421 tgtattgagg gacatcacct tctttctcac ataagaagca cgcatataag actgcaattt 93481 tgtcagagga taatgtgata tctcaatatc atttaatttt gtgttaacgg ttgtcttcaa 93541 caattttgaa cgacaatatg cttgcaaaag ttcgacagta cacgaaaacc ttgagagtgt 93601 aaatttcaat ttatcgtatt tatatcgaat tctgcttccc ttaattcgcg attgaatcgc 93661 ctcgacatga ggaacgtcaa tctttgctct tcttattggc aaatacattg atgacaatac 93721 tctaaattta tttcctctta ggcatgcttg aaaccttagt atgtcctgtt caaaaaggtt 93781 cagtaacctt ttttgaatgt ataggttaaa acgggtatta actcctcgac aaatattttg 93841 cagttgaact accttctcta aaaattgttc ctctgtcatc ctttctcttc tcatgggaga 93901 ataatgagaa ggtgagtatt tgaacgtctg gtaataattc aaatcttcct ctcttgcacg 93961 actccttctc gtataaaatt ctgtatcata tgtcaagtat ttcgagatgg taggagaata 94021 gtacgacaga cttttgtttt ttattgggct atattctaaa gatggtgtag ggcccagaag 94081 actcggctca atgggtgtga atttcctctt ctcaacaacg acatccaaat ttgacatttt 94141 tggagcttca ttataaggtg aaggtgtatt agaaaaatcg gagcaattag catctgttat 94201 attctttctt ggggtaatta aaatttcttc caccggtata ttcggccttt caaatttatt 94261 aaagtctttt atcaatccgc ttcttttttc ttttggttcc tcaggggaag ctggtgcagt 94321 attgatatta gttcctaagg acttgaagtc tctaattcta ggccatgctt ttttacaagc 94381 tgcgatttct tctttggtaa aacttatttg gcccgataca tttgttaaag cgggcgtttt 94441 gcctggccat ttcttattaa tcattgatat aagaatatgc agggtttcga aaacctgagg 94501 gatattcttc ttgttataga gatcttgcaa ttcaaatcta aaagagtccg gaacaccgac 94561 atgttctacc aaaccaaaaa aggcattaat gttctgagtg tgtttaaatt gtagtttatc 94621 acctgcagga aatataaccg ttgtcaaatc tggatttatc ctctgggtta gcttggccaa 94681 aaaaacacca ttcctaagtg agtctccaac acataactct atttctgatg gtagtgcttc 94741 ctcaataaca gcttcaatcc atattttgac ttctgatact ctgcataaaa actcatagta 94801 cctcagttct attttcgaat aattacttaa gtctacggta tattttccta cgagtttgtt 94861 aggaagggat ggcttcagct ttgatacgga actttctact ttttttgaca aaattgtcgc 94921 agaactgttg ctagctgacg tcttagtctt taaatgactt ggcgacgcta tgtttaacga 94981 agagttgatt ttggaacttg actgcggtct cagaggtgga gtcacattgg tgcctaggtt 95041 ttcaacataa cgatttagat aagaattatt attgcctggt ttcgaaggag agcctgaata 95101 tgctgtcatt gtttttgcac caccttgtta catataattg aactggtgca ataagttttt 95161 caaaaaaata atctatgttt tggccaacta ctttcttatt ttcaataaaa agctgttgtt 95221 ttctgatgtc aataacaggg tttcttaatt tcaagatgga agaatttgta atgtttacac 95281 tttcctcttt taggatatgc tattaatggc atgcttaaat cactatatac gaaataaaca 95341 attttagcga tgcgtagctc aatataaagc gctataagta agcgcgaaac aactgcattg 95401 tatccttgtt acaaatatca aaatcttcaa atgcaaaggc agaattgtcc tcagtttctt 95461 cgctttggaa ggggttagag aaatcttgta taattaggtg gtcccgagtg cttgcgttga 95521 aaatgcattt gtgacaattt tctatgatta ccacttgttt gcaatcgata cttggcgaga 95581 gtttctctat caaaattttg caatttttca agtcacgtaa acggatttgg aaatccttgt 95641 cggaaggaga ccgtagaaaa attatagaat ccgtacaatc agttatgaaa atactccctg 95701 tttgaaagaa aatcctttgt aagtttatga cacatttagt aatattgcga aagcacaaag 95761 aaccagaaag ggcactattg ccactataat ctgttgttga tgtaacagta caaaactcta 95821 aattttcaaa agctgaatca cccttctcca agacataatg ctttttcaaa gtagtggtat 95881 acgccggcgc attcgcaagc tccgtacgtt caacattctt atgaacggct gatgatgaat 95941 ttttctgttt gaaggagaat agtcgttttt tgccctttga ctcagataat tttgcattaa 96001 tagattttaa tacattttct atatcattgg agaagtgttc tttttcataa gatgtcaaag 96061 aatgtgacag agtattcagc tcacttcgaa gacttatggt cttcttctgc aaggtcttat 96121 agtcactcgt ctctgagagt tctcgttcga gctctacaca aaaaaatagt atacgaaaat 96181 atgcaatgtt aattagttgg acgcataatg aaagcagatg agtttcaaca taccctttat 96241 cttcgcagta aagtccattt atgcttaagc tatttcagtt atattcttaa gtatatttca 96301 cgatttcaga ttcttcgcgt tttgtatgac acactagacg cgtcggaata gtgaaaactc 96361 taaaaaaata cattgtaatg ttttacccag ttatttccat gcagatgccc tatttacata 96421 cttatttatt cattcgaata cctatacgtt atattatgtt ttgtttataa cctattcaag 96481 gccatgatgt tctacctaat ctacctcttc catttcggtg tcagctggaa cctcttcaac 96541 cggagctgcg gtggatgctt ctggagcagt ctctgtttct tcatcctcat caatgttcaa 96601 acccaaagag atcaatctgt taattcttga tgcaaaggaa gttggttcgt ccaaactgaa 96661 gccggaagtc aacaaagcag tttcatataa taacttagtc aagtccttga cagtcttgtc 96721 ttgagcacca ccttcgtcaa ctctcttttt caattccttg ataattggag attttggaga 96781 aatttcgaaa gtcttcttgg aagacatgta ggaggacatg gaagagtctc tcaaggcttg 96841 agccttcatg attctttcca tgttagcaga ccaaccaaat tgaccagttc tgatagcagc 96901 tggggcatcc aacaatttgt aagaaacaac aactttctcc acttggtcac ccaaaatttc 96961 tttcaaggcc ttggtcaatg gttcatattc tttgatctcc ttctctcttt cagctttttc 97021 ttcgtcagtt tcttccaatt cgaaatcttt agtaatgtca accaaagttt taccttcgaa 97081 ttccttcaat tgagtgaagg cgtattcatc aattgggtcg gtcaagaaca aaacctcgaa 97141 gtttttagcc ttcaaggcat ccaaaaatgg agacttttcg acagccttta gagattcacc 97201 agtgatgtag tagatgttct tttggtgttc tggcattctg gtaacgtaat cagttaagga 97261 agtcaactca tctacggact tggtagagtt gtaacgtaac aacttagcca aagcagccct 97321 gttttgggta tcttcatgta cacccaactt gatatttttg gagaaagccg agtagaactt 97381 ttcaaattgt tcagagtctt cagcaatttc gttgaaggct tcaatcaact ttttgacaat 97441 gttctttcta ataaccttca tgatcttatt ttgttgtaac atttctctgg acaaattcaa 97501 tggtaaatcc tcagagtcaa caacaccctt gacgaaagat aaccactctg gaatcaagtc 97561 ttcagcttca tcagtgatga aaacacgacg aacgtacaac ttgatattat tcttcttctt 97621 tttactctca aacaagtcga atggtgctct ctttggaatg aataagatag ctctaaattc 97681 caattgacct tcaacggaga aatgcttaac gtacaatggg tcttcccagt cgtttgaaat 97741 agacttatag aaagcattgt attcttcttg agtgatatca gatgggtttc tagtccacaa 97801 aggcttagtc ttgtttagtt cttctatctc ttgaacttct tctttaactt ttttcgtctt 97861 tggcttcttt tcctcttctt catcgacttc ttccaatttt ggtttcttgt cgtcttcatc 97921 cttcttttcc tcatccttct tttcctcgtc tttcttttct tcttctggaa ttggaacttc 97981 cttttcaact tccttggtga cgactaattg gattgggtag gccacgaact cagaatgtct 98041 cttgataact tcctttattc tcttttcttc caagtactcc aattggtcat ctttcaagaa 98101 taacctcaag atggtacccc taccaattct ttcattaact tcgtctagag taacagtgaa 98161 agaaccacca gcgttggatt cccagatgta ttgttcgtcg tcgttgctct ttgaaataac 98221 ctgaactctg tcggcaacta agaataaaga gtaaaaacca acaccgaatt gaccaatcat 98281 ggatacatcg gcaccagcag atagagcttc catgaaggct ttggtaccag acttggcaat 98341 ggtacccaag ttattaatca attcagcctt ggtcatacca ataccagaat ctctgatttc 98401 caaaactttt tgctctggct ttggagtgat tctaataaag agatctggtt ctgtttccaa 98461 ttgctttgga tcagacaaag atttgtatct aattttatcc aacgcatccg aggcattaga 98521 tatcagttct ctcaagaaaa tttccttgtt agaatagacg gtgttgatga tcaaactcat 98581 caactgagta atttcagctt gaaattcaaa agtttcacta gccatatctt tgcgtgtttg 98641 tttgtgcttt tgtttatagg actctatttt ctatcaggta tgatttcttg aactctaata 98701 cagcgggaag aaatgaggag gtcacagatg ttaagaattg aagggataag ctgcatattt 98761 atatgtttta gggggtggcg gaaggacctg gttggtatta agatgagaat taaccgctca 98821 taaaaccatg cgcgtgtttt tcttccacgg cgttctagaa aaaaaagaaa aattcaaaaa 98881 gttctgcgaa actcgaaaga accagaattg ttcgaacaat atgtgacaag cgtatgagtt 98941 aataatccga ttaagcttta ttcctgttct tttttacgtg tatgtaaaac tggtttatgg 99001 attactgtgt tgagagaggg ggggtgacac cctccggaat gtgatatatc acacgcttgc 99061 acgttggttc atatcgtaac cacgaagaat acaaatacgc acacgcaagc taagttatat 99121 tttaaaatat tctgtcatca agcttccaaa tacttctaac catctcttat tctcctctta 99181 gtagccattc tttgccacga ggaataaaaa gtcccgcgcc actaattaca ggaaaagaaa 99241 aataggacaa ttccatttga tgtcaccgtg gtaatatcac catgaacgat gatatgaaat 99301 tttcatagaa taagaaggaa aagtaataaa agaaaaagag aatctgagaa aaaatcgatg 99361 agttaattat catttgtgta aaacaaaaac gaattgtaat acgataggca aaattgttcg 99421 cgctctatct caaagaaagt aattatttcc aaatagaaaa aaaaaatcta catatacgca 99481 gatatgggcc tacacagtga accgttagat caagaggacc aagacaccat aatactcgat 99541 gcaagagctg gcgatttgga ttctctgaaa gatatattta caactttagt cagtcccgag 99601 ttactttcga cttgtaagga aagtgaatct gattctacgg ctttacatat ggctgctgcc 99661 aacggtcata tagagaccgt tcggtatata ctggagacgg tttctcgcgc aaatagtgcc 99721 gaagacttga aagcttttgt taatgaggtg aacaaaacag gcaacacggc tttacattgg 99781 gcgtcgttga atggcaaatt agacgtggtc aagctactgt gtgatgaata tgaggcagac 99841 ccctttatta gaaacaaatt cggccacgat gctatctttg aggccgagaa cagcgggaag 99901 gaagaagtgg aaacatactt tttgaagaag tatgatgtcg aacctgaaga tgatgaagaa 99961 gacacacaaa ctgagggcaa gaattcggtc caaatcacaa agggtacaga aattgaacaa 100021 gtcaccaagg aagccaccga ggctttaaga gaagaaaccg agaaactgaa tataaataaa 100081 gactaaagta aagagcttgt tttcttcgtg gaataaaagc cgtaatatcc attgagcatg 100141 atattttatt tcttggtacc ggagaagata aaaggatgga accagcagaa atgcattaat 100201 aaatacaaaa aatttagaaa agagttacag taataatgta tatttctctc acaaactaag 100261 taaccgcttc aaaagcgtat attttgaatg cattgaactt tccatttcat tacccgcaga 100321 gccggagtcc tcatcaacga cggagtgaaa aattttgtaa ttgcgagaaa aagtgaaatt 100381 gatggaaaaa aagaaaaaga aagtagaaga agacattata agagagacta ggaaacttct 100441 tgcacatcaa ccgaaaagcg cctaggcaac cagtcatata ataagcacgc acgagatgtc 100501 ctccgattta gctgctgagt taggattcga ccctgcacta aagaagaaaa agaagactaa 100561 gaaggtgatc ccagatgatt ttgatgctgc cgtaaacggc aaagaaaatg gttcaggaga 100621 tgatttattt gccggattaa aaaagaaaaa gaagaagtcc aagagcgttt ctgccgatgc 100681 tgaagctgaa aaagagccta ctgacgacat agcagaagcc ttgggtgaac tatccttgaa 100741 gaagaaaaag aaaaagacaa aggacagcag tgtagacgcg tttgagaaag aactagctaa 100801 agctggtcta gataatgtgg atgctgaaag caaagaaggc actccaagtg ctaattccag 100861 cattcaacaa gaagttggcc taccttattc agagttatta tctagatttt tcaatattct 100921 aagaactaac aatccagaac ttgctggtga tagaagtggt ccaaagttca gaattcctcc 100981 tcctgtttgt ttgcgtgatg gtaagaagac tattttctcg aatatccaag atatcgccga 101041 aaaattgcat agatctccgg aacatttgat tcaatatctc ttcgcagaat taggtacgtc 101101 cggttctgtt gacggtcaga aaagattagt cattaagggt aagtttcaat ccaaacaaat 101161 ggagaatgtc ttaagaagat acattttgga gtatgtcact tgtaaaactt gtaagagtat 101221 taacaccgaa ttgaagagag aacagtcaaa cagactgttc tttatggtct gtaaaagttg 101281 tggttctacc agatccgtct cttctattaa aaccggtttc caagctaccg ttggtaagag 101341 aaggagaatg tgatgttggt gctttacctg ttagcatata tataataaat acggatttcg 101401 tttatcttgt gtattttatt cgtttcatta gatatttaat gtttaaatga agaaaaactt 101461 aaagtaaaaa ttttcattca caaaataaat ctaaacagcg gtaggtaatc ttcattgatc 101521 agagtgaaca cattgcatgg agccagccaa tcatcgtgtc ctgtttactt cccaaggaca 101581 ggaaaaagct ttgagaagca aaaccgatca agtgtctaaa tcttgtaaaa gatttaataa 101641 ttggctggta gtaggccttt gtataggatc cacttgaatg catttcttga ttacactcaa 101701 aagcccctca gaaaatctgg aatttctcgg gaaactgtac ttaccagtgt ttatagcgta 101761 ggttaaagaa gctccatgta tctgctcttc tcgctcaaag ggggagatac cgaacattaa 101821 agtatagaac gtacaaccca aagaccaaat atcaacctta gagctcaaaa cctgatttaa 101881 tttcaagttc agaagttctg gtggagtata tggcaacgta caattgtcat tgacccattc 101941 ttgtagttcg ctgagttgat gtctgttttc aattgttata tcagcttgag agcaggagcc 102001 gaggtcacca attactggta aaccgtctga agagaacaaa atgtttgaag gtgtaatatc 102061 gcgatgtgca tatgctattg aacctgctga gttggaggaa agcatgtcca tctctaaggg 102121 ggtgtcttct aggagcatcg ccgtttcatc gctataagtc atagaaaccg catcgacatt 102181 tactctggaa gtagcgttat cttgtcttga cgcaggatca tgtaaacaaa gtaaacctct 102241 tgtaactcca agcattatcc ttacgcattc tgcctctgat acaaaggtgc cctcgagtaa 102301 cctccgatta atagagtctt gtaaactccc taatgaataa tagggtagta ctatgtaaat 102361 tgtttttgac ccatcttttt cctgcattac ttgtgagtcg atacttttta taacataagg 102421 actttgaaac cgtttgtaat tttcaatttc tcgcatacca ttggatatac tttccacact 102481 aggacaaata atcttcttta gtgcgtataa ttctggtgtt gcgatgccgt tgtctataat 102541 cagagaattc tttgacagtt gtaccaaata cacaaaggac attccacctt ctccaagtag 102601 tcgttgaatc ctatatcgtt tatcatttac cctaatagta gcatcggaaa atccgcgaca 102661 gcagcacaag ttctggaaca attccaatac aatagaaatc attgatcgga taagatggta 102721 caatcgttat tttatcccta gtcagtcgct gagattacag gctctttttg tctactctct 102781 gtttcgtctt tttggagaaa gtatggttca acatcttaca aaaccagata ccgaaaatgt 102841 ccctaactcg gtgtcataag acaggactta tcaaaacaga aaggatcttg caaaaaagaa 102901 aaagagcaaa ttatgtaaac tttgggggtc aacacagttg tatcagtcgt attggttaga 102961 cccaatatag cggttttctt tacttctttg tttctacact tattaaagtc tatttaactc 103021 cctttcacgt gatcagtttg aaagaaacgt gaaaattatt tttttcagcg aactttttga 103081 aggttttcaa tagaagatga aagctaaatg aagactgtac attcacacgg gaaacgagag 103141 aaagaagttc agttagttga agccagcaat actactttct ctagcagtct agcacaagtt 103201 actttgaaag gaaataaaaa aaattgtcag catgtcgatt caaactagtg atccaaatga 103261 aacatcagat ttaaagtcgt tatctttaat tgctgcccac tcccatatta caggtttagg 103321 tctagatgaa aacttgcaac cacgtcccac atccgaaggt atggttgggc aattgcaagc 103381 ccgtcgtgct gctggtgtga tattgaaaat ggttcaaaat ggcaccatag caggtagggc 103441 tgttttggta gcgggccccc cttcaactgg taagaccgct cttgccatgg gtgtttccca 103501 gtctctgggt aaagatgtac cattcactgc tattgcgggc tcagaaatct tttctttaga 103561 attgagtaaa actgaagcac taactcaagc ttttaggaaa tccatcggta tcaaaatcaa 103621 ggaggagaca gaattgattg aaggtgaagt cgtggaaatt caaattgata gatctattac 103681 tggtggacac aaacaaggaa aattgactat taaaactacc gatatggaaa caatttatga 103741 attaggcaat aaaatgattg atggcctaac taaagaaaag gtattggctg gcgatgttat 103801 ttctattgat aaagctagtg ggaagattac caagctaggc agatcctttg ctagatctag 103861 ggattatgat gccatgggtg ctgataccag atttgttcaa tgtccggaag gcgaactgca 103921 aaaaaggaaa acagtggttc acacggtgtc actgcatgaa attgatgtta ttaattcaag 103981 aacacaagga tttttggcat tatttactgg tgacaccggt gaaattaggt cagaggtaag 104041 agaccagata aacacaaaag tggcagaatg gaaagaagaa ggtaaagcag aaattgttcc 104101 tggtgtatta tttatcgacg aagtccacat gttggatata gaatgttttt cctttataaa 104161 tagggctttg gaagatgagt ttgccccaat cgtcatgatg gctacaaata gaggagtttc 104221 caaaaccaga gggactaatt acaaatctcc acatgggtta cctctcgatc ttttggatag 104281 gtcaattatt attacaacta aaagttataa tgagcaggag attaagacaa ttttatctat 104341 aagagcacaa gaggaggaag ttgaactgtc atccgatgcc ttagatctat tgaccaaaac 104401 aggtgtggaa actagtttgc gttacagcag taatttaatc tctgttgctc agcaaattgc 104461 aatgaagaga aaaaacaaca ctgttgaagt ggaagatgtc aaaagggctt atttgctatt 104521 tttggacagc gctagatctg ttaagtatgt tcaagagaac gagtcacaat atattgatga 104581 tcagggcaac gttcaaatat ccattgctaa atcagcagac cctgatgcca tggatactac 104641 ggaataagca ttttgtactt taaggcagaa attgcatcaa atatatatgt ataaataaaa 104701 attttatgtt tgcgtgattg ttggtgataa gaagtaaaaa agtacaccta aaataggcag 104761 cagttggcca gcacgttcag aaccccgtat gatatacctt ctttcgaata attatcgatt 104821 atcaaatgta tagatagcag tattataata tatactatat tctatacata tatgaagggg 104881 gttggtgcgt gtatatgaga aaaaattttt ttattgtaat tatttttttt ttttaaactt 104941 ttgactcatt cagagcctct agtgttcaaa atcaaagcta caatcatacc atataaccct 105001 aaaacttcag agaaaattag aatcaaaacg ataccgacaa aaagccttgg ttggtgcata 105061 tactttctaa caccaacgtc accgaccata ccaatggcgt agccactact caaacaggca 105121 aatcccacac agagcccaca actcaagtgc atgaacccat tgaagagagt atagtcttcg 105181 gtaggagata aattacctgc aattaaaacg gccacaacaa gcccataaat ggctaagata 105241 ccactcataa ccacaggaat caaagacttc atgatcaatt ccggcttgaa agtacctata 105301 ccggcgatac caatacctga cttagctgta ccaatggcag ctcccaaaca ggaaagcacc 105361 atggcagctg cacaacctgc gaacccgaaa aagggagcgt acaatggagc atatatgtta 105421 cttgcgagtt gcgttgacat gtttacagag aataatagaa tggacccttt cctcctccga 105481 ctcttgcttt gctatattta tttttttttt tcttacgagt aaagaagaaa atattaggtt 105541 atctatgttc ctttttctaa ctaatcactc tttcactaaa gaatatttct tagcaaaaat 105601 atgcgtacct gcgtaccggg taaaaagtcg cattgtccaa gtgctgctgc ttttacgcaa 105661 aagaacacat ctaaccgaag aggaataagc agacctgaac aataccaaat aaagaagtta 105721 cttcttcttt atcaccattt tgacaggttt ctacattttt ttttccgtag agggaaaaca 105781 tataaaagca gtccagtaat tgcttgcttt ttgaaatggc tctttaagcc tgaaagcaca 105841 agacgattag tgatatagat aatatataca cagatacaca tgtacgtaca taagtactga 105901 tttaggctgc aaccttttac ctggctcaac tgacacgaat attttgttat cagccaaaat 105961 aaacgttcat gatatatagt gagaaaaaaa gatcgatggg acgactcgcg gccattcctt 106021 gtgcgtgcag gaatcaagaa aataaacaaa ccggtacagt acaataagca ggctgagtag 106081 gcggaaaaag ttttattcag acgtgtaccg gagcctaaat cctttcttac ccatagcaac 106141 cacactaaat atattattgt aacacgagaa gatgtcacaa ggtcagtcca aaaaactgga 106201 cgtaactgtt gagcagcttc gaagtatata ccaccagttt catgatatct tggaagaaaa 106261 aactgatttg catctaccga agaaagaata cgacgatgac gctgttagga gagaggttca 106321 gatacagtta caagaatttc ttttgagcgc tatgacgatg gcttcgaagt cactagaagt 106381 tgtcaacgcc gacacggtag gaaagacggt aaagcaattg atcatggaat cacaagagaa 106441 gtacatggag ccctttgacc ttgacctgaa tgagcaagtt agaaagatgt accaagagtg 106501 ggaagacgaa accgttaagg tggcccagtt gaggcaaacg gggcctgcaa aaatcaacga 106561 agtttacaac aactcaaagg atgagtattt ggcacaattg gatgggagaa tcggcgttct 106621 tcaagctaga atgatgcagc aacaatctgc tgaccatgat gatagtaccg acgatgccga 106681 tgatcacatc aactgggagc acatcaagca ggattacgtt gcctcactca atgaattgta 106741 tcaaacacag caagacctac ccaaggtaag atataacgtt gaaaaggtca agcgcttaat 106801 ggacttcctg gaggaggatt gaataaataa catataagac agtcaacctc gtggtaaatg 106861 ataactatat tctggggctt tattcatttt tttacacttt tttatctttg tacgaagagc 106921 tgaaaataaa aaagtataga gccagccttt tcccacacac taacgacaaa agacgatatg 106981 caggctgtgc gcatggggga gaatccagtt tttgcccgtt aaagagaaaa aattagtgtc 107041 tgtgaaacgc gaatacaaaa aaagaaaagt agcaggatct tacttctcgt aaagacgtca 107101 agaaccaaat caagtcaaat cgtggaagtt acaaggggaa agaccaataa cttttagtaa 107161 agaacaaaga aaggtctatc tcacgcagtg acggtctttg cggtaaatct gtgtatactt 107221 gaaagaaaac ccttttacaa ttaaaaaagg caattaaaaa tagaaacaaa tcaaatgagt 107281 tataataatc cgtaccagtt ggaaacccct tttgaagagt catacgagtt ggacgaaggt 107341 tcgagcgcta tcggtgctga aggccacgat ttcgtgggct tcatgaataa gatcagtcaa 107401 atcaatcgcg atctcgataa gtacgaccat accatcaacc aggtcgattc tttgcataag 107461 aggctactga ccgaagttaa tgaggagcaa gcaagtcact taaggcactc cctggacaac 107521 ttcgtcgcac aagccacgga cttgcagttc aaactgaaaa atgagattaa aagtgcccaa 107581 agggatggga tacatgacac caacaagcaa gctcaggcgg aaaactccag acaaagattt 107641 ttgaagctta tccaggacta cagaattgtg gattccaact acaaggagga gaataaagag 107701 caagccaaga ggcagtatat gatcattcaa ccagaggcca ccgaagatga agttgaagca 107761 gccataagcg atgtaggggg ccagcagatc ttctcacaag cattgttgaa tgctaacaga 107821 cgtggggaag ccaagactgc tcttgcggaa gtccaggcaa ggcaccaaga gttattgaaa 107881 ctagaaaaat ccatggcaga acttactcaa ttgtttaatg acatggaaga actggtaata 107941 gaacaacaag aaaacgtaga cgtcatcgac aagaacgttg aagacgctca actcgacgta 108001 gaacagggtg tcggtcatac cgataaagcc gtcaagagtg ccagaaaagc aagaaagaac 108061 aagattagat gttggttgat tgtattcgcc atcattgtag tcgttgttgt tgtcgttgtt 108121 gtcccagccg ttgtcaaaac gcgttaattc caactatttt ctatatttct attctatccg 108181 aactcccctt ttgtatatca atatatctta atactttcgc ctattcttta ctatatttcc 108241 taaattttct ctggtctgca ggccaaaaac aacaacttac tactgaatca tggacgtgta 108301 tttagtttag ccaagcaata tttaaatatc actcttccta aaaatacatt gggcattacc 108361 cgcaaactaa cccatcgctt agcaaaatcc aaccattttt tttttatctc ccgcgttttc 108421 acatgctacc tcattcgcct cgtaacgtta cgaccgaaat ctcactaagg cacggtttgt 108481 tgggcagttt acagatgttg gataaccagt tgtttctaaa cggttatgcc tcatatataa 108541 cttgttaact gaaggttaca caagaccaca tcaccactgt cgtgcttttc taataaccgc 108601 tatattagac gtttaaaggg ctacagcaac accaattgaa ataccatcat tatgaagccg 108661 gaagttgagc aagaattagc tcatattttg ctaactgaat tgttagctta tcaatttgcc 108721 tctcctgtga gatggattga aactcaagat gtttttttga aggattttaa cactgaaagg 108781 gttgttgaaa tcggtccttc tccaactttg gctgggatgg ctcaaagaac cttgaagaat 108841 aaatacgaat cttacgatgc tgctctgtct ttacatagag aaatcttatg ctattcgaag 108901 gatgccaaag agatttatta taccccagat ccatccgaac tagctgcaaa ggaagagccc 108961 gctaaggaag aagctcctgc tccaactcca gctgctagtg ctcctgctcc tgcagcagca 109021 gccccagctc ccgtcgcggc agcagcccca gctgcagcag ctgctgagat tgccgatgaa 109081 cctgtcaagg cttccctatt gttgcacgtt ttggttgctc acaagttgaa gaagtcgtta 109141 gattccattc caatgtccaa gacaatcaaa gacttggtcg gtggtaaatc tacagtccaa 109201 aatgaaattt tgggtgattt aggtaaagaa tttggtacta ctcctgaaaa accagaagaa 109261 actccattag aagaattggc agaaactttc caagatacct tctctggagc attgggtaag 109321 caatcttcct cgttattatc aagattaatc tcatctaaga tgcctggtgg gtttactatt 109381 actgtcgcta gaaaatactt acaaactcgc tggggactac catctggtag acaagatggt 109441 gtccttttgg tagctttatc taacgagcct gctgctcgtc taggttctga agctgatgcc 109501 aaggctttct tggactccat ggctcaaaaa tacgcttcca ttgttggtgt tgacttatca 109561 tcagctgcta gcgctagtgg tgctgccggt gcaggtgctg ctgccggtgc agctatgatc 109621 gatgctggcg ctctggaaga aataaccaaa gaccacaagg ttttggcgcg tcaacaactg 109681 caagtattgg ctcgttatct aaaaatggac ttggataacg gtgaaagaaa gttcttgaaa 109741 gaaaaggaca ctgttgctga acttcaagct cagttggatt acttgaatgc cgaattaggt 109801 gaattctttg ttaacggtgt tgctacttct ttctctagaa aaaaggccag aaccttcgat 109861 tcttcctgga actgggctaa acaatcttta ttatcattat actttgagat aattcatggt 109921 gtcttgaaaa acgttgatag agaggttgtt agtgaagcta tcaatatcat gaacagatct 109981 aacgatgctt tgattaaatt catggaatac catatctcta acactgatga aacaaaaggt 110041 gaaaactatc aattggttaa aactcttggt gagcagttga ttgaaaactg taaacaagtt 110101 ttggatgttg atccagttta caaagatgtt gctaagccta ccggtccaaa aactgctatt 110161 gacaagaacg gtaacattac atactcagaa gagccaagag aaaaggttag gaaattatct 110221 caatacgtac aagaaatggc ccttggtggt ccaatcacca aagaatctca acctactatt 110281 gaagaggatt tgactcgtgt ttacaaggca atcagtgctc aagctgataa acaagatatt 110341 tccagctcca ccagggttga atttgaaaaa ctatatagtg atttgatgaa gttcttggaa 110401 agctccaaag aaatcgatcc ttctcaaaca acccaattgg ccggtatgga tgttgaggat 110461 gctttggaca aagattccac caaagaagtt gcttctttgc caaacaaatc taccatttct 110521 aagacggtat cttcaactat tccaagagaa actattccgt tcttacattt gagaaagaag 110581 actcctgccg gagattggaa atatgaccgc caattgtctt ctcttttctt agatggttta 110641 gaaaaggctg ccttcaacgg tgtcaccttc aaggacaaat acgtcttgat cactggtgct 110701 ggtaagggtt ctattggtgc tgaagtcttg caaggtttgt tacaaggtgg tgctaaggtt 110761 gttgttacca cctctcgttt ctctaagcaa gttacagact actaccaatc catttacgcc 110821 aaatatggtg ctaagggttc tactttgatt gttgttccat tcaaccaagg ttctaagcaa 110881 gacgttgaag ctttgattga atttatctac gacactgaaa agaatggtgg tttaggttgg 110941 gatctagatg ctattattcc attcgcggcc attccagaac aaggtattga attagaacat 111001 attgattcta agtctgaatt tgctcataga atcatgttga ccaatatctt aagaatgatg 111061 ggttgtgtca agaagcaaaa atctgcaaga ggtattgaaa caagaccagc tcaagtcatt 111121 ctaccaatgt ctccaaacca tggtactttc ggtggtgatg gtatgtattc agaatccaag 111181 ttgtctttgg aaactttgtt caacagatgg cactctgaat cctgggccaa tcaattaacc 111241 gtttgcggtg ctattattgg ttggactaga ggtactggtt taatgagcgc taataacatc 111301 attgctgaag gcattgaaaa gatgggtgtt cgtactttct ctcaaaagga aatggctttc 111361 aacttattgg gtctattgac tccagaagtc gtagaattgt gccaaaaatc acctgttatg 111421 gctgacttga atggtggttt gcaatttgtt cctgaattga aggaattcac tgctaaattg 111481 cgtaaagagt tggttgaaac ttctgaagtt agaaaggcag tttccatcga aactgctttg 111541 gagcataagg ttgtcaatgg caatagcgct gatgctgcat atgctcaagt cgaaattcaa 111601 ccaagagcta acattcaact ggacttccca gaattgaaac catacaaaca ggttaaacaa 111661 attgctcccg ctgagcttga aggtttgttg gatttggaaa gagttattgt agttaccggt 111721 tttgctgaag tcggcccatg gggttcggcc agaacaagat gggaaatgga agcttttggt 111781 gaattttcgt tggaaggttg cgttgaaatg gcctggatta tgggcttcat ttcataccat 111841 aacggtaatt tgaagggtcg tccatacact ggttgggttg attccaaaac aaaagaacca 111901 gttgatgaca aggacgttaa ggccaagtat gaaacatcaa tcctagaaca cagtggtatc 111961 agattgatcg aaccagagtt attcaatggt tacaacccag aaaagaagga aatgattcaa 112021 gaagtcattg tcgaagaaga cttggaacca tttgaggctt cgaaggaaac tgccgaacaa 112081 tttaaacacc aacatggtga caaagtggat atcttcgaaa tcccagaaac aggagagtac 112141 tctgttaagt tactaaaggg tgccacttta tacattccaa aggctttgag atttgaccgt 112201 ttggttgcag gtcaaattcc aactggttgg aatgctaaga cttatggtat ctctgatgat 112261 atcatttctc aggttgaccc aatcacatta ttcgttttgg tctctgttgt ggaagcattt 112321 attgcatctg gtatcaccga cccatacgaa atgtacaaat acgtacatgt ttctgaggtt 112381 ggtaactgtt ctggttctgg tatgggtggt gtttctgcct tacgtggtat gtttaaggac 112441 cgtttcaagg atgagcctgt ccaaaatgat attttacaag aatcatttat caacaccatg 112501 tccgcttggg ttaatatgtt gttgatttcc tcatctggtc caatcaagac acctgttggt 112561 gcctgtgcca catccgtgga atctgttgac attggtgtag aaaccatctt gtctggtaag 112621 gctagaatct gtattgtcgg tggttacgat gatttccaag aagaaggctc ctttgagttc 112681 ggtaacatga aggccacttc caacactttg gaagaatttg aacatggtcg taccccagcg 112741 gaaatgtcca gacctgccac cactacccgt aacggtttta tggaagctca aggtgctggt 112801 attcaaatca tcatgcaagc tgatttagct ttgaagatgg gtgtgccaat ttacggtatt 112861 gttgccatgg ctgctaccgc caccgataag attggtagat ctgtgccagc tccaggtaag 112921 ggtattttaa ccactgctcg tgaacaccac tccagtgtta agtatgcttc accaaacttg 112981 aacatgaagt acagaaagcg ccaattggtt actcgtgaag ctcagattaa agattgggta 113041 gaaaacgaat tggaagcttt gaagttggag gccgaagaaa ttccaagcga agaccaaaac 113101 gagttcttac ttgaacgtac cagagaaatc cacaacgaag ctgaaagtca attgagagct 113161 gcacaacaac aatggggtaa cgacttctac aagagggacc cacgtattgc tccattgaga 113221 ggagcactgg ctacttacgg tttaactatt gatgacttgg gtgtcgcttc attccacggt 113281 acatccacaa aggctaatga caagaacgaa tctgccacaa ttaatgaaat gatgaagcat 113341 ttgggtagat ctgaaggtaa tcccgtcatt ggtgttttcc aaaagttctt gactggtcat 113401 ccaaagggtg ctgctggtgc atggatgatg aatggtgctt tgcaaattct aaacagtggt 113461 attattccag gtaaccgtaa cgctgataac gtggataaga tcttggagca atttgaatac 113521 gtcttgtacc catccaagac tttaaagacc gacggtgtca gagccgtgtc catcacttct 113581 ttcggttttg gtcaaaaggg tggtcaagct attgtggttc atccagacta cttatacggt 113641 gctatcactg aagacagata caacgagtat gtcgccaagg ttagtgccag agagaaaagt 113701 gcctacaaat tcttccataa tggtatgatc tacaacaagt tgttcgtaag taaagagcat 113761 gctccataca ctgatgaatt ggaagaggat gtttacttgg acccattagc ccgtgtatct 113821 aaggataaga aatcaggctc cttgactttc aactctaaaa acatccaaag caaggacagt 113881 tacatcaatg ctaacaccat tgaaactgcc aagatgattg aaaacatgac caaggagaaa 113941 gtctctaacg gtggcgtcgg tgtagatgtt gaattaatca ctagcatcaa cgttgaaaat 114001 gatactttta tcgagcgcaa tttcaccccg caagaaatag agtactgcag cgcgcagcct 114061 agtgtgcaaa gctctttcgc tgggacatgg tccgccaaag aggctgtttt caagtcctta 114121 ggcgtcaagt ccttaggcgg tggtgctgca ttgaaagaca tcgaaatcgt acgcgttaac 114181 aaaaacgctc cagccgttga actgcacggt aacgccaaaa aggctgccga agaagctggt 114241 gttaccgatg tgaaggtatc tatttctcac gatgacctcc aagctgtcgc ggtcgccgtt 114301 tctactaaga aatagagaga gcactacgta gtccctcttt taatatgtaa cgtgtcgctt 114361 ctatttatca gacataatag taattacttt gttatttttc tatcgtttcc ttactttagc 114421 ctctgatttc gatctggcct aatcattgtg tacgtctata atcatatggc cctgagcgta 114481 cacaccgttc aattcttcta tttggtcggc ccacacaaat tcgcgcgggg gcatattgac 114541 gcgtggaaga atagaagtcc gcgtagcagc tctggggtaa ttaggctttt acgatatcgg 114601 ctggcccagc accggttttt attcctcccg tggttgttgt ctctaccgtg aggaggggaa 114661 agggtcaggg acggccggta gttatgttgt ctcaacgatt actgccatct attgtttaca 114721 ccaatcgcgt ggggcaaggg gctggaaggc tgtggtgtac agaatagggt ctaatacccg 114781 atgcgcgacg ctcctgcgac tggttgtgtg agccacccct tgatcgcctc tgccaaatac 114841 tcagggaaga gaaaaatcgc gaaggtggac gagtgccctt aaagaaccag catcctcgat 114901 cgccgctgcc gttcgccctg gcttagcggt gggaagcatc ctttggcttt cgaattctcc 114961 gccgttgagt ccccctaagg gccttattta tcccctctat ttttttttag aaaatgtttt 115021 ctttttcaag atttgtttgc tccttcacgg cttccccctt aaccgttcaa cagtcttccg 115081 tatataacaa tctcaatcca ctcttattgc ctataatttt gattaattct tattcatccc 115141 ggcagataaa gtttcgtctt gttttgaaag agacaggagt tcttggctgc agtattttgc 115201 aacagcttca ttaaccatgt atgtaaagaa aaaatctgga gcgacttact ggcttagctt 115261 tttttactaa cacataaata atactgtgat aagataagaa aaaaacacga aatggaaaat 115321 accacgaatc gtaatactgc aggcgttctt acgagcagca atggtaactt tgccaccaat 115381 agtgtagcgg catcaactcc gaagaggtcc aaaagtgctc gaaggaaaac gttcaaatgc 115441 accggatatg acggttgtac gatgtccttc actagagcgg aacatcttgc acgtcatata 115501 agaaagcaca ctggtgaaaa gccgttccag tgtcctgcat gtttgaaatt cttcagtaga 115561 gttgataatt tgaaacagca tcgggaatcg gtccatgcac ataaaaacca ccattctacc 115621 agctcgcacc agcgtaagcc ttcctcttca tctttatcct cctcttcttc tgcatcttct 115681 tcgtcttctg cttcatcatc tacatcatat agtgatcctt acaggaaaac taatattaat 115741 agcgggaaca tgccgatgat ggcagaaaac gaaaaagcgc cccaaataat acattcttcg 115801 ccggagttca ttactagcac gagaagcatc ccacccatct ctccaaggtc catttataat 115861 acccaacgac agcaacaaca ccaacaacaa cagcatcaac aggctcccta ttattttcct 115921 tcccatccaa tcactgatag ttactaccag tatcctcttc ccagtaataa taacaccatc 115981 aattatttac catcagtaga tgtgcagtat cctttgaatg tgagcccctc ctcaacgagc 116041 catccggcct ctgaggtaat catatcgtcc tttcctccga ggtccatgcc aagtacttcc 116101 ttcaaatata aagattctgc cgactttcaa gcacggacaa ctatgaacaa atacaatatt 116161 agaccaagca atatcaatgt caatactagt aatatcaata accatcttga ttcattctcc 116221 ccgccgtttt ctccgtcaac gacagttgct gaagcaaaac caattatttt accacagtat 116281 cagcaggcat ttagccaacc accaaatgga aataaaaaca ataatatgtc ttcctcgaag 116341 aatggcggca aagggggaga aaatttcaag aatactgatg atcgcaatga taataataac 116401 aaaaagaggt cggaaacttt atcagagtct gatatttcgg tcaacaccaa taagaaaagg 116461 cttagtgttg attacatatt gacttgatcg aggcaatctg atctaagttt caaatattcc 116521 gtagagtata aatatcttac aactaatata attcttaata tgcgcaaaca aattatggtg 116581 cgcatctttt tttattttta tgttttgttc catactaaat gcagtttata aaatttttca 116641 aatgagtcaa gctatgtata atcagtgcta caaaaatgat aagatgcaat tgcaagaaaa 116701 aatcccttgc ataaagggct ttctgacctc ttgcgttgat caacgagaaa taaccgcaaa 116761 acttaatttt aaactcccgc gtctgcttta cacagcccac agtagcatca aaaactacga 116821 tgtaacacta acggtggatt gtgaatacgg aacgaacaat cctgcatctt gacttcaaaa 116881 cttgatcata tacacctata ccgccatggt tatctcgccc ttacgctcac ccggaccccc 116941 gttaattgca ataataagaa aaagaaaaga aagaagcttt ttatctcatt tcactgacaa 117001 gatgacgctt tttccgattt tagcagataa actatcacat ataaccactt ttttatatta 117061 catgaaatga tgccctacaa cacccctcca aatatccaag aacctatgaa cttcgcaagc 117121 agcaacccct ttggtattat tccagatgcg ctcagtttcc agaatttcaa atatgatcgt 117181 cttcagcagc agcaacagca gcagcaacag cagcaacaaa atcgcactgc gtcatcgtta 117241 cagcagccgc aacagcaaca accaataagc ccgcctttgt ttttagtagg ggccggtacc 117301 agcgaaaact caaaccttaa caagaatgcc aacactagta ctatccctcc tttactcttt 117361 agcagatcgt ctcagcatta tgttgtccca gatatagacc actcctccat aatatacaag 117421 aacaacatct gcaaatcttt caaagatgac ttatttttct gtccaagatc tttactttct 117481 ctcgaagaac aacaagcatg cgagaaaatg gataggctga ccgctgaaca aatgtcattg 117541 tatcatcaga acacgcaatc cagttctaat cctggttcta tgtcttcttc acctccaaat 117601 tctgcttctt ctatattcaa ctctaggccg aagttcaatc cttatacatc tcaaagtttt 117661 aatcctttgg aaagtgttca agaatgatcg cgatatggac aaacacgttg ttttgatttc 117721 ttttttgcat attcctcatt tgaacaaatc ttgtgtccat gttatgttac gttatgttat 117781 attatgtcaa gccgtttcat ttcctactta tttttaatta tcggtttctt ctattcatgt 117841 agttcactat tcaattagta tatgtagata aaaggagaag ggttttatct gcaaacagac 117901 gcaagacgta tgtactaagc actaaatact catataacca tattctttca aaaatacatg 117961 ccatttttct gtttcataat aatcctggag gctacaagta tggtgatata ataaatcttg 118021 aaccttgttt tactggaact cctaaagtca agccatacat aatgccagaa acaggacctg 118081 cgtagataac atataacatg taccagtcat gattacccaa cgtgccgtta caaatgatat 118141 atagacctac attttagtta gtttcgtcgt aagttatggt aataaaggaa aagtcctcta 118201 atgaatctat aatataggtt cacacaaata agagtgataa ttaaaagcgt attcgacact 118261 gaaagatctg ctgggaatac tatactgata tttccaaaat atcccttata aattgaatct 118321 ggaatagcac ttcttttttt aaaaaacctt gaattgttgg tagcatttct atcctcccac 118381 tatgagttac actgacaacc ctcctcaaac aaaaagagct ttatcgttag acgatctggt 118441 gaatcacgat gaaaatgaaa aggttaaatt acaaaaatta agtgaggcgg ctaatggcag 118501 cagacctttt gccgaaaatt tagaatctga tataaatcaa acggaaacgg gccaagctgc 118561 tccgattgac aattacaagg agagtactgg tcatggctcg cactcacaaa aacctaaatc 118621 acgcaagtca tctaatgatg atgaagaaac cgatacggat gacgaaatgg gtgcaagtgg 118681 agaaattaat tttgattcag aaatggactt tgactatgat aaacaacata gaaatttact 118741 atccaacgga tcacctccta tgaatgatgg tagtgatgcc aatgcgaagt tagaaaagcc 118801 ttctgatgat tcaattcatc agaatagcaa gagtgatgaa gaacagagaa taccgaaaca 118861 aggtaatgaa gggaacattg ccagcaacta tataacccaa gtacctctgc aaaagcagaa 118921 gcaaactgag aagaagatag cgggaaatgc agtaggaagc gtggtcaaga aggaagaaga 118981 agcgaatgca gctgtagata atatttttga agagaaagct actttacaat caaaaaagaa 119041 taatatcaag agagatttgg aggttctgaa tgaaatatct gcgtcttcca agcccagtaa 119101 gtacaggaat gttccaattt gggcacaaaa atggaaacct actatcaaag ctcttcaaag 119161 tataaatgtg aaagatctca aaattgaccc atctttttta aacattattc ccgatgatga 119221 cttaacaaag tcagtacagg actgggttta tgctacaata tactcaattg ctcctgaact 119281 aagatccttc attgagttag aaatgaaatt tggtgttatt attgatgcga aaggcccaga 119341 tcgtgtaaat ccaccagttt cttcacaatg tgttttcact gagcttgatg cccatctaac 119401 gcctaatatt gatgcatctt tgttcaaaga gttgagcaaa tatattcgtg gtattagcga 119461 agtcactgaa aatacaggta aattcagtat tattgaatcc cagacaagag attccgtcta 119521 tagagtcgga ctatccacgc aaagaccaag gtttttgaga atgagtacag atattaagac 119581 tgggagggta ggacaattta tagagaaaag acatgtagcc caactactat tatattcacc 119641 aaaagatagt tacgacgtta aaatctccct aaacttggaa ttacctgtac ctgacaacga 119701 tccgccagaa aaatataaat ctcaaagccc aattagtgaa aggacgaaag accgtgttag 119761 ttacattcat aatgattcct gtaccagaat tgatattaca aaagtcgaaa atcataacca 119821 aaattcaaaa agtagacaat cagagaccac tcacgaagtg gaactagaaa tcaacacgcc 119881 tgcactgtta aacgcctttg ataacataac gaacgatagt aaagaatatg catctcttat 119941 tagaacgttt ctgaataatg gtacaattat tagaagaaag ttatcgtctt tatcatatga 120001 aatttttgaa ggttcaaaga aagtcatgta atatttgaat catttcaaaa aaaaataagc 120061 aaatgccctt gagcgagaaa ttttttttgt ttactcaaat gctgttatga aagcttatgt 120121 aataataata ataatgataa taataacata aaaataatta ctctaacatt tcttattatc 120181 tctatatatc cctaataaat aggccattct tataataacc aagtctttcg ccattttgat 120241 actatcaata gctaaagcca tcttagagcc atcaacctca tgccaggaaa ttggtatctc 120301 ctcaatttgg attctttttc tgatggctaa gatcaaaatt tcaacgtcaa agatccaacc 120361 ctctgtatgc aaatacggaa aaattttcaa tatagcggct ctgttgaaca atttgaatcc 120421 acattgtgtg tctttgatag acctgatgcc gaagatgaaa actaaggtat ggaaaccgta 120481 catcaagcag tttcttatca ttgatctctt tatgacggct tcggtattta ccatatgtgc 120541 tctggaacca attgctactg ctggtttagt cgtttttaga tctgtactag acgtttcaat 120601 tttgctaata gcatctatta gtttttctac atcactgaac ttactagcac catcagcatc 120661 ggcaaaaaga ccatacttac ctctaatatg taaaaaacct tgtctcactg cgccaccttt 120721 gcctctgttt tgagaaaact tgatgattct gaattgttcg tagttcaatt tgaactgttc 120781 tttacaaatt ttcaaacagt attgtgtggt attatctgtg gaaccatcat ccactatgac 120841 aatctcccat ctggaaccat atttttcctt taaaaagctg attgcgtctg tcaacattag 120901 taaaattcta cctgtctcat tatagcttgg gataacaaca gataaaaata tttcttcgtc 120961 atcttggtgt tcattcaagt taggtaaggc acgactaact tcatgacctt tttcatcaat 121021 agctatgtat ttgagctcct ctggatatgg cggccttggt gtatgcgaaa ataaatagac 121081 caataaatac agtgaaagca ccaaggctac taagagcgta aaaaagacag tgtttctgtt 121141 ctcaatcagg aatctcaacg ctctcatttt tgttgtgctt tgtgtaattt ttggctgcct 121201 ctctgttttt gtccctttct tacgttatca aaagcaccta atctatcctt acagcatcca 121261 attagatacc actacctttc cacagtgact atggtccttt gtgccacttt aattgcgata 121321 aagccttgaa aattggcacg ttttcttctt gtttacactt tttttcgaat acgccaaatt 121381 tcgctttctc atgaaaaaaa tggcatacac tgcttcgaaa gatacaacag agccatgtgc 121441 attaatatat ataaattaaa aggtactgaa gtgataacgg tgaaaatagg ataactatgt 121501 acacttgact ttggacttgt tagttgtgac tagtatagaa gttacaagat caaatggaat 121561 aaacccaaac accacatcta atttttcaat ggaaaaagaa aagtttcaag gtggaaaaaa 121621 aattttcagc agcatcgcaa taaatgttaa aaaataataa tatattgcaa cctatttaag 121681 ataatacata tgcgtcgatc tatagtgcat aatttatatc ttgtaaactg taaatacaac 121741 gacaatcagt gctaattcaa ctcaggatgc ctccaaagaa gtttaaggat ctaaactctt 121801 tccttgacga ccaaccaaag gacccaaatc tagtcgcttc tcccttcggt ggttatttta 121861 aaaaccctgc tgctgatgcc ggtagtaata acgcttccaa aaaaagtagc taccaacaac 121921 agcgtaattg gaaacagggg ggcaactacc aacaaggtgg ttaccaatcg tataacagta 121981 attacaacaa ttacaacaac tacaacaact acaacaatta taacaactac aataactata 122041 ataaatacaa tggccagggc tatcaaaaat ctacttacaa acaatcggct gtgacgccca 122101 accaaagtgg aactccaact ccatctgctt ctactacatc tttgacctct ttgaatgaaa 122161 agctgtcgaa cttagagtta acacccatct ctcaattttt gtcaaagata cctgaatgtc 122221 aaagtatcac tgattgcaaa aatcaaatca aactaatcat tgaagaattt ggcaaagaag 122281 gtaacagtac gggtgagaaa attgaagagt ggaaaatcgt cgatgttcta tctaaattca 122341 tcaaacctaa gaatccatca ttagttagag aatctgccat gctaataatt tccaacattg 122401 ctcaattttt cagtggaaag ccaccacagg aagcatactt gctaccattc ttcaatgtcg 122461 cacttgactg tatttcagat aaagagaata cagtcaaacg tgccgcgcaa catgccattg 122521 attctttgtt gaattgcttt ccaatggagg ctttaacctg ttttgtactg cctacgattt 122581 tggattactt atcatctggt gccaaatggc aagctaaaat ggccgctcta agcgttgtag 122641 atagaataag agaagattcg gcgaacgatt tattggaact tactttcaaa gatgcagttc 122701 cagttttaac cgatgtagca actgatttca aacctgaatt ggccaaacaa ggttacaaaa 122761 ctttattgga ctacgtttct attttggata acttagattt gtctcctcgt tataaattga 122821 tcgtggacac cctgcaagat ccatctaagg ttcctgaatc tgtaaaatcg ttatccagtg 122881 ttacatttgt cgctgaagtt acggaacctt cactatcttt gttagttcct attctaaaca 122941 gatctttaaa cctatcgtca tcatctcaag agcaattaag acaaaccgtt attgtcgtgg 123001 agaatttgac aagattggtg aataatcgta atgaaattga aagcttcatc cctctactac 123061 tacccggtat ccaaaaggtt gttgatactg cgtccttacc tgaagttcgt gaattggctg 123121 aaaaggccct taacgttcta aaagaagatg acgaagctga taaggaaaac aaattctcag 123181 gcagactgac tttagaagaa ggtagggatt tcttacttga tcacctcaag gacattaaag 123241 ctgatgattc ctgttttgtc aagccttaca tgaatgacga aactgttatc aagtatatga 123301 gcaagatttt gaccgtggat tctaatgtga acgactggaa aagacttgaa gattttttga 123361 ccgccgtttt tggtggttca gattcacaaa gagaatttgt caaacaagac tttatccata 123421 acttgagagc tttattctac caagaaaagg aaagggcaga tgaggacgaa ggtattgaga 123481 ttgtcaacac tgatttctcc ttagcttatg gttcaagaat gcttttgaac aaaacaaatc 123541 ttcgtctcct aaagggtcat cgttacggtt tgtgtggtag aaatggtgct ggtaagtcta 123601 ctttaatgag agcaattgct aatggtcaat tggatggttt tcctgacaag gatacattac 123661 gcacctgttt cgtcgaacat aaattgcaag gtgaagaagg tgatttagac ttggtttcct 123721 tcattgcttt agatgaagaa ctgcaatcta cttctcgtga ggaaattgca gccgctttag 123781 aatctgtcgg ttttgatgaa gagagaagag cacaaactgt tggatcttta tctggtggtt 123841 ggaaaatgaa gttggaattg gcaagagcta tgttacaaaa agctgatatt ttattgctgg 123901 atgaacctac caatcattta gatgtttcga acgttaaatg gttagaagaa tacttactgg 123961 aacatactga tattacttca ttgattgttt cgcatgactc tggtttctta gatacagtct 124021 gtactgacat catccattat gaaaacaaga aattggctta ctacaaaggt aacttggcag 124081 catttgttga gcagaaacct gaagctaaat cttactatac cttaacagat tctaatgctc 124141 aaatgcgttt cccaccccca ggtattttaa caggtgttaa gtctaacact agagccgtcg 124201 ctaaaatgac tgatgtaact ttctcttatc caggtgccca aaagccttcc ttaagccatg 124261 tctcctgttc attgtctctg tcttctcgtg tggcttgttt aggtcctaac ggtgctggta 124321 aatccacttt gatcaagcta ttaactggtg aattggttcc aaatgaaggt aaagtggaaa 124381 aacatccaaa tttacgtatt ggttatattg ctcagcatgc attgcaacac gtcaatgaac 124441 ataaggaaaa gacggcaaac caatatttgc aatggcgtta tcaattcggt gacgaccgtg 124501 aagtcttatt gaaggaatcc agaaaaatat ccgaagatga aaaggaaatg atgacaaagg 124561 aaatcgacat tgatgacggt agaggtaaga gagccattga agctattgta ggtagacaaa 124621 agttgaaaaa atctttccaa tatgaggtca aatggaaata ctggaaacca aaatacaact 124681 cctgggttcc aaaagatgtt ttggtcgagc atggctttga aaaattggtt caaaaattcg 124741 acgatcacga agcctccaga gaagggttgg gttaccgtga attaattcct tcagttatca 124801 ccaaacattt tgaagacgtt ggtcttgatt ctgaaattgc taaccatact ccattaggtt 124861 ctttatctgg tggtcaatta gttaaagtcg ttattgccgg tgctatgtgg aacaaccctc 124921 atttacttgt tttggatgaa cctaccaact atttggacag agactctctt ggtgctttgg 124981 ccgttgctat tcgtgactgg agtggtggtg tcgttatgat ttcgcataat aacgaatttg 125041 ttggtgcttt atgtcctgaa caatggattg tggagaacgg taaaatggtt caaaagggct 125101 ctgcacaagt tgaccaatcc aaattcgaag atggtggtaa tgctgatgcc gttggtctaa 125161 aggcctccaa cttggccaag ccatctgtag atgacgatga ttctccagct aacatcaagg 125221 tcaagcaaag aaagaagaga ttgacaagaa atgaaaagaa gctgcaagcc gaacgtcgtc 125281 gtctacgtta cattgagtgg ttgtcatcgc caaaaggtac accaaaacca gttgatactg 125341 acgatgaaga agattgaaag cctactggct agtgttttat cttcgctaac ttcgtttgtt 125401 tcactccatc ttttttcttt aattcactcc tcaaatggag tttactacgt tgatagaatt 125461 taggacaagc atatgacgct ctccttcctt ttttgttttc taggttaatt catttttcat 125521 acagagtagt taatattggt tcttttcata tatgtacggt acgcagatta attatgtaaa 125581 cttaaactta agggatcctt tttgatgcta acaattgtcg atgttgaact acaaatttat 125641 gtaagaggtc gttgttaagg attattattt taaaaataca cgaagattga ttattatttc 125701 ttacatgagg ttatgaatcg tgctccaaaa gtataccaaa aataactcct gaactgctag 125761 gcacagtttg cgataattta aaggggttaa atacactttt actactggct ttcaccttat 125821 aaatccctca ttaaactaaa gatgaatgaa cattgttgaa gaaattgtcc gggtaagagg 125881 ttgtactagg gagtgatgaa catccataaa ttcttcgact agcagaagta atgataattt 125941 tcacccgtta aagctacatc tggttagatg gactagaaga accacgacga aacaatcata 126001 taacaatgtc tacttttaat gcagaaaccg ctgataactt ggaagatatc gagaaacaat 126061 tcgctgttgt tgctgttgaa caagcggaaa catattggaa actattaaca agtgttcccg 126121 gttccaagtt acgtttgact aagtttgatg acgaaatata cgagaatttt atggagagat 126181 tcccagaata caaagatgtt gaaagggtca aaaagtttac ggaggaagaa ttaaaaacaa 126241 aagaagccaa ggaaagatgg agaaagttct tcacaatttt tgagaaaaaa atcgaagact 126301 ataactttgg tactttgttg aggacagacg cttcagccga gtatggtcaa tttactactt 126361 gttttgtcgt gagactacaa ttttacgctt ttgaaattgc tagaaataaa cacggcttga 126421 acgattggat tgtcggtcag aaatgaacat gcatatatat ttgtgattga ttatatagaa 126481 tacattactt tatacaaagg aacaacacaa ggcattcttc cttgttcaac atatatatat 126541 atacatatat atattaagct cagtaaattg ttgaaatgtg aaaggctgta cttttgctct 126601 taacttttga aaaaattcat cattgagaat tccctaatgt ttatgggtgt gagtatcggc 126661 agaatcagaa tgagtatgag tatgatttgt tgatttagtg tcatgagagt gctccaaatc 126721 acctttagag tcagaggtta catcaacaaa ctcgacgtcc accttcccca cgtttggcac 126781 cttcatacgt aaatcctctc ttatagtcga aatagcgttt tccaaaaatc ttatcccaac 126841 ttcctgacct gaatgtaata ctggcacttc caaagttgtg gtggcacgaa gattaggacc 126901 ggaagctaat atagtaaggt ctctaacatg taacgactgt ttgagatcta agtctgtttt 126961 caaactgcca atgctgtctt ttatgacaga ttcgatttct agataacgcg gatcagtagg 127021 tggtatagat tggtcaacta actccttcag tgaggataag ataccttgtc cacctgtttt 127081 tatgatcaaa cctgacacta caagcccacc taaattatct aaggattgaa tgttgaaaaa 127141 ataactagat gtgatagcga ccaacgctac caacgatgtc aaggagtcaa cacgatgatg 127201 ccaggcgttt gccattagta cattagaatt tgtttggatt gcaactttct ttgttgcctg 127261 aaaaacccat tctttaacca agatagaacc cgctgctatc catacagcat ttacattagt 127321 tgcctgttgt gttagcgact gagaatggga atgcgtttca ccaattaaac cggccatcga 127381 ttctagaatg gcatgaggaa tgacaggccc cacaatagcg cataacgacg accaaccgat 127441 agatatacca gccattgcta agattgtgga tactgccaaa gatcccacag tttccacttt 127501 accatagcca tatgggtact ccgaagttgg tttacgagac gcatattgga cagaaaacag 127561 tgttaaaaaa tcagatacca aatcgctaag agcatgtacg gaatcagcaa gtaatgcttg 127621 agaatgaaaa gtgattcctc ctacaaattt tcctactgcc atccccacat ttgatgcaag 127681 tcctatccat gttattctta cgccaggatt cttcttgatc tgctgtacgt tcagtgacaa 127741 taaaggattg tcatgcatat gtgtgtggct gtgactatga gtatgttgca acaacgactt 127801 cacagaggaa gccttgcctt ccttctttcc ttcactttca ttctgtctgg aattcgatcc 127861 attctgtgaa gacatttttg aaatgagctg ttcattatag ccctcttctt gaccttcttt 127921 atttagcagt ttcgaagaat gcaggcacct tctcgggttg gctgagatca ttgtactgta 127981 caggcttgat gttcttatgg ccctcccggc agcatggtaa ctagtgttgt tataacctgg 128041 cacaaaggaa ccgaattgct tgatagagtc aatacttatc cgtagcatat ctttattgcg 128101 tttgcttttt tgagaaagta attgcttaca cgttctagaa taaaaaagta tggttgtaag 128161 aacgcacttg aaaaggcacc aatctgctcg ggtttttaca actaacacta acctagatga 128221 gaggtaaaaa gaaatcgtaa aaaaaagttg ttgcccagca caataacgac actttacccg 128281 ctaattccag gaggtttgag ttagacaacg accttcccac cccgttttcc cataattcta 128341 ttgttataca cctggatctg gaggtccgtg aaacggcata cctcgacgaa aaaggtcact 128401 actaatcaaa tcaaactgac attaataaaa acgtataaac tgacagctgt agatctaaat 128461 aaactagatt aaacatatga aatagtttgt aaaaagtggc atcatgacca ataataggtc 128521 cagatgaaga aaaaagaaaa aagaagacga aattagggta aaatttctca cttgctgctc 128581 aagggtgaga cccgcacctc aggcatgtaa tagaagcttc gaccaccgca tctaccagac 128641 gccttggttc ccactatcat catcatattc atcgtttcct gacccagaca gatcgcgtct 128701 accgctgccg atattagagg attggtagcg gttactttga gcacctcttg tacgaccttg 128761 tttttgctgt tggcccgaag tcaagaagtc atcgtcttca tcgtcgtcca actgaccttg 128821 agtgttagtt tcgcggtaag tttgggtata agtgccacca ccagtgccgg cagtgtagtc 128881 agtagtttgt tgctggaagt cgttaccgcc aaactgcgtg ttaccgccta gattagactg 128941 tggctgctgg cgttgaggga aattcccttg gttttcttcg ccgtagggat cggccttgga 129001 tccttgattc ctgaattccc tctgttgatg tttttcatga cgctgttgtc tagtctggtc 129061 gtcattgtcg tcttcgtaac gttcatcatg atcgttgccg tgcaacttat cagcaaactt 129121 gtttaataga ttggacattt cttaattgtt attcgtactt agcttttatg cggtagtgtt 129181 tggctctgct gctagtagat attaagagtt gagggtaggt atgtatcctt tttttgatga 129241 aatagtaatg tgcttttata gtccaagaaa tattgactgc ttcaagggag cctgattaac 129301 aagcacgtaa cggagaccaa aaaaaggatt tcggtctttt ctaaccattt ccctttactc 129361 ccttgtgcgt tatttgtttt gattactagg catgatgtat ggaggaactt gcgatcaaat 129421 gtcataaaag tggaggagtg aaaagaaatg acgaagccca aaacgtggtc ctagaattac 129481 cacatttcct ttttctaaag gaagccagac tatgctttac gcaagaactg tggttaaaga 129541 gggatattct gatgaacata aattcataca cattcatgag aagcacgaca aggattggtt 129601 aattacttac aactaaggca aaactgccat tgacctcatc tgtaccacca catgctgtgt 129661 agttattttc cctttgtgat ccctaaaaaa gatgggatct acacacctta caagaacatc 129721 ctcaaaccca tacctggaac cactgaacat attcttcccg tgaaaggctc tacggcgaaa 129781 ctactgtaat gtcacaggaa attaaggatg cttcgactat ggaacggacc atacatgggg 129841 acccgatgta tagaaagcct caatgaggca aagagtctag ctcctttaag atacgtaatt 129901 ctccttctgt tttcccttaa ttattcgggt gaaataccac atggtcgcac ggctgacggg 129961 gaactccgga attggacgat gaagaactta acggtgatat gaggtgatcg tggaacaaaa 130021 cgttgtgcca aagaagccac aaatacgtca ctgtaattat tctgcctgca taaaaagagc 130081 catcaaggat aagctagaga ctatactccg gaagtagaag aaggaaggtg tgagaaagaa 130141 gatagagcgt gtaacacaat catgggggaa aaaaggacaa taatcaaagc gctgaaaaac 130201 tctgcagcgt cccacttcat caagaagttg accgcagata cttccctgtc gtccatacaa 130261 gaggcaataa acgtcgtgca gcagtacaat gcaacggatc ccgtgagatt aaagcttttc 130321 catacgcctc ggatggtttc gcagggggct cattttgcat tttgtttgcc cactaagaaa 130381 ccacattaca agccattact gctttcgcaa aacgcacttg atgagtttaa tttggtgcag 130441 gatcaggact tggagaaaat actatccggt gagaaagtat attattccga tagtatcttt 130501 ccctatagta cagtgtactc cggatttcaa ttcggctcat ttgctgcaca gctgggagac 130561 ggacgtgtgg taaacttgtt tgatcttaag gacaagtgta gcggacaatg gcaaacgttt 130621 cagttgaaag gtgccggtat gacgccattt tctcggtttg cagatgggaa agctgtgtta 130681 agatcaagca tacgtgaatt cataatgagc gaggcgttgc acagtattgg aattccatcc 130741 acaagagcta tgcaattaac tctgttaccg gggacgaagg cgcaaaggcg caatcaagaa 130801 ccgtgcgctg ttgtatgccg ttttgcgccc agctggatcc gcttgggtaa cttcaaccta 130861 ttcagatggc ggcacgactt gaaagggttg atccaactat cagattattg cattgaggaa 130921 ttgtttgctg gggggaccca atttgagggg aaacccgact ttaatatatt caaaagggat 130981 ttttttcctg acactgagac gaagattgat gagcaggtgg aaaaggatga aactgaggtg 131041 agtaccatga ccggagataa catttccaca ttgagcaaat atgatgagtt tttcagacat 131101 gtagttagct tgaatgcaaa cacagtggcc cattggcaag cgtatgggtt tgctaacggt 131161 gttttgaata cggataacac ctccattatg ggcctgacaa ttgattatgg cccctttgcc 131221 ttcctggaca agtttgaacc aagctttacc ccgaaccatg atgacacagc gaagagatat 131281 tcgtttgcca accagccaag cattatatgg tggaacttgc aacagtttgc caaggatctc 131341 gcatgtctgc tgggtcctga ggcccgtgac cttgaattgt tacttaaggg cgaactgaat 131401 tctgttgatg acgccctaga gaaaaccatg attgaaaggg tccagaagtt ggtagagctc 131461 agtgctaatg agtacaagta tgtgtttacg acaaggtacg cgcagataat gtctcaaaga 131521 ctcggtgtag atctggatct ggaaaagtgc atgtcttcta caaacctcaa agatatcgaa 131581 catgcagccg agaaggctaa agagttctgc gatgttatcg tcgaaccatt gctagatatt 131641 ctgcaggcca caaaagtcga ctataacaat ttttttatcc atctacaaaa ttacaagggg 131701 cccttcttca tcaaagataa aagtgacacc gcaacacttt ttggagcatt cgatgaagag 131761 tacttgggta tgttcttcaa ctccaagcaa ctgcagcaaa tggcagaaac tgaagaggcc 131821 ttcgcggctg gtgagaaggt ctttgacgct aacggcgaat tgcgtttgct caacgaaaaa 131881 ttgcaagaaa tacgcaattg gacccaagac tatttgacct tggtcccacc cacggaaact 131941 gctgcaagag cgtcgcttgc caagaaagcc aacccgttgt ttgtccccag aagttgggta 132001 ctggaggaag tagtcgacga tttaatgtac agtcaaaggg atggcctaca agatcccagt 132061 tcggagctag atacatctgc gttgaagaag ctatacctaa tgagcgtaaa cccatacgac 132121 cgcacgaaat gggatgtcac tctgcggcca gaactggaga caaaatgggc tgacctttcc 132181 caccaagatg acgctaagtt tatgatgcaa gcttcctgca gtagctaaat gaccacagat 132241 gtatttatac attcatagct atatatatac atatatatat atacatgtaa tatggcgcaa 132301 gtaggcacgg tagtcaccaa ttgctcaggt atctcctcgg tgtaaaagca cgtacaccgc 132361 gttcggagag tcgtttataa actcaaaagg ggaaagagac aagggtagcc gaacgactgg 132421 caccggacac gaacacgaaa acttatttag attattaaaa aaaaaaaaaa aagagaggaa 132481 acgaggcgga ggcggagagg aggagagaga caagagacgg gcagaacaag aagggtaaaa 132541 acagtgagaa acagtctccg ccgttttgac tgcgtatcca tcgttattgt ccactacgag 132601 acgctaatga cgaaacgagc taccacatgc gtttcctacg cacctgctaa agacctgaca 132661 ctttaaagga cccatcttct ggccttctgt cccgggtgct gaccaagctc tcttcctttt 132721 ccttgcattt tttatatatt aatactcact ttctttccga tttttatttt tgagtcttct 132781 taagcaaaat cctgctatgc gaatctgaac cgatcgctcg agaactaact taaccatact 132841 tgctcacatt gccgttttgg gaaactgcgg aatttttttg ggaaagaaca agaaataagc 132901 ggaggcacac atagaaaaaa gaaacgcaga aagatcaagc acggatattt ctggctagag 132961 gtttataaaa gaaagaatac ctggcagcaa agagattatt ttcattattg acacacatac 133021 ccgaccaaaa acggcgttaa gaatgcaagt actagtgacg ctctggtgtc taatatgcac 133081 atgcctggta ctaccagtgg ccgccaagaa aaggacactg acagcgagtt cactggtcac 133141 gtgcatggag aactcacagc tttcagccaa tagtttcgat gtgtcgtttt ctccagacga 133201 tcgatcgcta cattacgatc tggatatgac cacgcagatc gactcttaca tctacgctta 133261 tgtggacgtg tatgcctacg ggttcaagat tattacggag aacttcgacg tgtgttcaat 133321 gggttggaag cagttttgcc ctgtgcaccc aggtaacata caaatcgact ccattgaata 133381 cattgcccag aagtacgtga aaatgattcc gggaattgcc taccaagtgc ccgatattga 133441 tgcgtacgta agattgaaca tttataacaa cgtaagtgaa aatttggctt gtatccaggt 133501 tttcttttcc aatgggaaaa ctgtatcaca aattggggtt aaatgggtga cagctgttat 133561 cgccggtatt ggtttattaa cttccgctgt cttgtccacc ttcgggaact ccacagcagc 133621 atctcacatt tctgcaaaca ccatgtcact gttcttatat ttccaatctg tcgctgtggt 133681 cgcaatgcaa catgtagaca gtgttccacc cattgctgct gcctggtctg aaaaccttgc 133741 ctggtcgatg ggcttgatcc gtattacatt tatgcagaaa atcttccgtt ggtatgtaga 133801 ggcgactgga ggctccgcat ctctatattt gaccgcgaca acaatgtcag tgctcactca 133861 acgaggtctg gattacctta aaaatacttc ggtttacaag agggcggaaa atgtcttgta 133921 cggtaactca aacactttaa tctttcgagg aattaaaaga atgggatacc gtatgaagat 133981 tgaaaatacg gccatcgttt gtactgggtt cacattcttt gtgctgtgcg gttatttttt 134041 ggccgggttt atcatggcct gcaaatacag tatcgagtta tgtataagat gtggttggat 134101 gcggagtgat aggttttacc aatttaggaa aaactggagg tcagttctga aaggatcgtt 134161 gttaagatac atctatattg ggttcacgca actgacaatt ttaagttttt gggagttcac 134221 tgaacgggat tccgccggtg ttattgttat tgcatgccta ttcattgtat tgtcatgcgg 134281 gttgatggcg tgggctgcgt acagaaccat ttttttcgca agtaaatctg tggaaatgta 134341 caataaccca gctgctttat tgtatggtga tgagtacgtc ttaaacaagt acgggttttt 134401 ctacaccatg ttcaacgcaa aacattattg gtggaatgct cttttaacga cgtatattct 134461 tgtaaaagct ttatttgtcg gattcgcaca ggcatcaggt aaaacgcaag cattggctat 134521 tttcattatt gacttggcgt attttgttgc catcatccgt tataaaccat atttggaccg 134581 tccaacgaat attgtcaaca tttttatttg cactgtcacc ttggtcaact ctttcctttt 134641 catgtttttc tcaaacttgt ttaaccaaaa gtatgctgtc tctgccatca tgggctgggt 134701 gtttttcatt atgaatgctg cgttttcttt gcttctactg ttgatgattc tggcctttac 134761 cacaatcatt ctgttttcta agaatcctga ctccaggttc aagccagcaa aggatgacag 134821 agcatctttc caaaagcatg ctattcctca tgaaggtgcc ttgaataagt cagtggccaa 134881 cgaattaatg gccctaggta atgtggcaaa ggatcatacc gaaaattggg aatacgaact 134941 gaagagtcaa gaaggtaaaa gtgaagataa tcttttcgga gttgaatacg atgacgagaa 135001 aacaggaact aattcagaga atgctgaaag tagcagtaag gaaaccaccc gtccaacctt 135061 ttctgaaaag gttttacgtt cattatcaat caaaaggaat aagagtaaac tgggcagttt 135121 caagcgcagc gctccggata agataacaca acaagaggtt tctcctgacc gcgccagctc 135181 ttcgcctaac agcaagtcat accccggtgt ctcgcacacc aggcaagaat ctgaagcgaa 135241 taatgggcta atcaatgcat atgaagatga gcaattcagt ctgatggaac caagcatact 135301 ggaagacgct gctagttcca cccaaatgca tgctatgcca gcccgagatt tgagcttgag 135361 cagtgttgca aacgcccaag atgttactaa aaaagcaaac atcctggatc ctgattattt 135421 gtaagctttg tcgatgggat aaaggtaaaa agaacaacgt aattaaatca ttacgaaaac 135481 tctactgcat tattttttag tctttttata gagacatgaa cattcaatta ctttcaagga 135541 taaatattct aatattcata ttattcactt atgtattttt aacgaaactc tactccattc 135601 tactgggatc gggcatactt tacggggtgc acggatttta gcagtctttt tctttcttgg 135661 cttttgcgag atgccttgag aggaagattt ttttttcact caaaacctct gtcttgtaca 135721 tatctagaac atgtttcatt gatattggac gttactattt caatttaaca gtcaaccagt 135781 cgtccaaaaa tgtccaagat cacttcttct caagtcagag aacacgtcaa ggaattgttg 135841 aagtattcca acgaaaccaa gaagagaaac ttcttggaaa ccgtcgaact acaagtcggt 135901 ttgaagaact atgaccctca aagagacaag cgtttctctg gttctttgaa gttgccaaat 135961 tgtccaagac caaacatgtc catctgtatc ttcggtgatg ctttcgatgt tgacagagct 136021 aagtcttgcg gtgttgacgc tatgtccgtc gatgacttga agaagttgaa caagaacaag 136081 aagttaatca agaagttgtc taagaagtac aacgctttca ttgcttctga agttttgatc 136141 aagcaagttc caagactatt gggtcctcaa ttgtccaagg ctggtaagtt cccaacccca 136201 gtttctcaca acgatgactt gtacggtaag gtcactgatg tcagatctac catcaagttc 136261 caattgaaga aggtcttgtg tttggctgtt gccgttggta acgttgaaat ggaagaagac 136321 gttttggtta accaaatctt gatgtctgtt aacttctttg tttctttgtt gaagaagaac 136381 tggcaaaatg ttggttcctt ggttgttaag tcctccatgg gtccagcttt cagattgtac 136441 taagcataat tacgtgtttt catagtttaa cgctttcaga actacttatt taattttgta 136501 agaagtaatt tgagtcacat ttgtatttag taaaagatta agagtatttc tatttcaccg 136561 ccttgatagg aaagagcggc gcggaagggc agctgtaggg aattttgctc tgtattcccc 136621 tgtttaatat caaaaacaac agagaaggat ccccgatgag aaagacgctc gggaggtctc 136681 tgtgtttgct aggcaattga catatttaaa agattttgtt tgaggttttg cagataaaca 136741 agaagcagta tggctaatga tcaagatccc aacaagtctc tcattaatga cgctttgact 136801 cggagtatgt ccgaatttta tgatgatgat gatgataacg acagtgacat gtgtagggca 136861 aatgatgagg gagaagacgt ttttgacctt ccacttaagg taggcgtttc tcaaagcagg 136921 aacttttcag aagtaaatga cgtgttagac ccgctttcta gtttgcatgg tccgtccaag 136981 aaggtgagat ttgaacagca aaagcagcaa cagcaacatc agcaacttca caatgacttc 137041 aatacagatt tcaacctgaa aagcccgtcc agtaaaaaaa tgggggtaga acagctgatc 137101 cagtcagcca atgaaatcaa cgattacctc gctaacaaca ttgacaaggt aaatagcttt 137161 aactcagagc tattgagcgg cagtggcaag ttacctggga gagtaaagag tgacacagca 137221 actcaaggta ccggacgctt agattccatg tccaactttg ctcttagcga tacggagttg 137281 gacaatgatg acgataatta tctcctggat ccccttgcaa atgctagctc tactacaccc 137341 actgtggaac accacggtta cagcttatta gacaaggctt tatccacgtc tgataaggaa 137401 aaaatatata cgaataaagt gaattcgaat agtcagatag atactgataa tcactctcac 137461 gaaagtggaa acactaccaa taacgaaaca gatgaaaatg agagttcgga gatcctggac 137521 tacacaaaat ttgattcttt cccctatccc ccgtcttctg cccccaatgg ggaaccacca 137581 gatttgaaag tgctaagcat tgaatgtgag caggaaaatg aaaaagagct acgacgaata 137641 tctttattat tggatcatta cgaatcaata ccgaaaatac cagaattgtc agacgatgaa 137701 gcactatcta agttccgtga gaatatcgaa ttaattttac aactatctaa gaaaattaac 137761 gataatgcga acactttagc gatttcctcc gaagatcctc aaaaatttgt taattttgtg 137821 atgaagaacc caccttcctt atcattcaga gattttatcg acagaatcca gaataaatgc 137881 atgtttggtg ccgtagtcta tcttggagcc acctatctac ttcaacttgt gtttcttacg 137941 agagacgaaa tggacggtcc cataaagttg aaggctaaat tacaggagga ccaagcccat 138001 aggatcatca tatctacaat aagaattgcc accaagctat tagaagactt tgtccactca 138061 caaaactaca tttgcaaagt cttcggtatt tcaaaaagac tgctgaccaa actggaaatt 138121 tctttcatgg cgagtgttaa tttcgatgga ttaatgatta cttgtgaaaa attagaaaaa 138181 acattgcata tccttgatga tacaagacag gcattaggaa acacatgagt tttgcatatg 138241 tattatgcag gttcatttgt tccttccctt atttcttttc atagtattta tttttattta 138301 tttatttatt tttttttgga ttttatttta tttctttttt aatgctaaga aagtaattcc 138361 gcataattaa acgtgtgctg gcctcgatag gtacctatag tatacagaag cttacgaaaa 138421 gctcctgcag gatggcactt ctaaaattcg cgctcaacat ggccgtattg tacattatat 138481 cgttctatca ttatatcgta tacgcccgca ttacccgaca actccgtctg caacgcgttg 138541 accagaaaac tcgaacaaga gatcgcataa aaaaccaaaa ggaaacgaat tacttgtcaa 138601 atagttattg taatggatcc tctagaaagg caaacagtag atttatttcc ttcttttcta 138661 gaaacatcat tataactaac aatatataat tggaataatg gctggttggg atatttttgg 138721 ttggtgtatg ttatcaccct gttcacgttt ttcggatact tagttttatt caatgtggta 138781 aacattgaat gttttcagct taagatctat tttttttttt ctagaagaaa ttgcgtcctt 138841 tactaacttt attttactgt acagtcagag atgtgttggc ttcccttggt ctgtggaaca 138901 aacatggtaa actacttttc ttgggtttgg ataatgccgg taagaccaca ttgctacata 138961 tgttaaagaa cgatagattg gcaaccttac aaccaacatg gcatccaact tctgaagaac 139021 tggctattgg taacattaag tttacaactt tcgatttggg tggtcatatt caagctcgtc 139081 gtttatggaa ggattatttc ccagaagtta atggtatcgt ctttttagtc gatgctgctg 139141 accctgaaag atttgatgaa gcacgtgtcg aattagatgc tttattcaac attgccgaat 139201 tgaaggacgt tccttttgta attcttggta acaagatcga tgctccaaac gccgtttctg 139261 aagcggagct acgttctgct ttaggattat tgaataccac tggctctcaa agaattgaag 139321 gtcaaagacc agttgaagtt ttcatgtgtt ccgttgttat gagaaatggt tatttagagg 139381 cgttccaatg gttatctcaa tatatttaat tgacgtatac atctataccc tttatatgac 139441 attcacatga attcaacagc tttgtaataa tcaacaaaat tgcataggat gccacctcat 139501 aacttttgag cacagcattt ccgcgatcat agtatatttt agactctaag attgaataaa 139561 agtatgatac atcttaagta tacatatata tatgtatata tatatatata catgaaagtt 139621 tacctcctca tcttacgtgg acgagattca tcgtcaccgc ccatagttgt tcttttacca 139681 ttctgggcga agtattcttt ctttttctcc ttatcccttt gtgatttttc ttcctccatc 139741 ttagctaatt ttttcaatct ttccttacgt tgactagcct tctgttcctt cctcttgctg 139801 tctttggctt tcgaaatcgt caatactttt tgaatgaatg atcttgcctt cttttcatca 139861 ccacctagca ccacggctct tttagccata tatgttttct tcttttgtgg tttcatttga 139921 tggatctgag atttgaatgg caattccttt tgaacagctt ttgggacctt tagaccattg 139981 aagtgtcttt ctacacgttc tattttatga tatgcactgt ccggattcga cggtgtttcc 140041 aggttcatag ccgctcttat ttggcctgtc aatcttaaac ctttccactc ggttttttcc 140101 ttcaacaata gtgaggtaac aggattatag aatttcttga cgcggacagg ataccatgat 140161 cttagaatta caatatcact cattaggatt ttatcctcaa aggctgccct atagtgaccc 140221 tcaggctttg aaagtgccct tttgatttca ccacggatac ccgagacagt tttgatctgc 140281 gcaccctcaa accttgcaac ttccatagca cttgaaaaca tgtcctttat aaaggcagta 140341 tttttgaaaa ttttatatgg aaacccaact aattttaact ttttaacaat ttcaatatta 140401 acgtctatct cttcaacgat acctgttgct gcaattctaa aaccgttccc ggtatcacta 140461 ttagcaacaa tttgaacacc acaaaaaggt gtgtttggag aacataaggg accgtagaaa 140521 gccgcattac aatatgtgtg ttctggtgta tactttagca ttctggttct tgttctagag 140581 tcagttgttg tataaattgg taaagtttgg aaccttctcc aacccaaaga caagaccagt 140641 gggtcatttg tcttcaaaat cttcttatgc caacgatgtc ttctcaacct ggctttgaca 140701 ataccgaact ttatttcggt cggcaataaa ccacccataa caattggaaa ttttggattg 140761 aaattcttga caaattccat tgggactttt tcgaaaacga tacgtacata agaaccagct 140821 ttgaaacctt cgattctttg acgttgttct ggagtcattt cttgatattc tatattgtta 140881 atttctaact gtttagatat cttggccttc tgtagttcat accatgtatc atattcattg 140941 ttttcatcat cttctttaaa gttttcacct tcttctatct cgaattgtgc acgtagtttt 141001 tccttctttg cagcattcat ttctctttct tgctccatgg ttaagtcctt tttttcctcc 141061 gcatcaaaat tagtgaatga attatcatca tctccattag tgtcttcgtt ttcatcctca 141121 tcctcacttt ctttgtcact attgtcttct gcttgttcag aagggtttcc atcttctaga 141181 tcttcaaaat cgccgtatag ttcttcccca ccttcattag agtcactttt cgttttatta 141241 tcattaccta aaatgcctgc gccgaggaat cgctctttga ttgcatcaac gcttttccat 141301 tttttagcca atttttcgaa agtgtcgaaa tatggaacaa acttttccaa atcaactgca 141361 tggtctttat tgccctcttt tgtaacagta ccatcttttt tcctgaagaa gtcatcatca 141421 acatcttctt caatgtcact ttcgtcttta ctatcgtcgt cctcgcccct ccaccttctt 141481 atacattctt caggtgaaat gttgtccatg tatatcagct taccgatatt ccaggtcctt 141541 ttcttacttt cagttttctt cagcttgttt gccgctgttc tttcccagga aaactcatct 141601 tcactctctt caaattcaga atctgtttcc aaagctaatt tttcggcacc ctgctcaccg 141661 gtattattga aatcgatttc aaccatcctt ggttcggagt cctgcacgtc gtcatcattt 141721 gtataaggtt cttcatcact cggtaaatta tcaatatctg cgtcttcttc ttgaactggc 141781 ttaccataaa ttcttggttt tcttaaactg gttcttccct tgctctttcc ttcatcgtcc 141841 tcaatacttt cttctccact ttcaacatcc atgccttcat gatcggcaac ttcatgaagc 141901 tcagtgccgt tgctaaacaa ttgcaaaccc acaccatcaa atttctctgc aatactttgt 141961 tcaacacttt gtaaacccgt catgagtttt tctccttcac ctctttcttg gccgggaaca 142021 aaacttggct cttcattttt ctttccaata tcaatataaa cagcatcctt atccatcaac 142081 acacctccga catcggacat tggagcatat atcaatttat ctttatcatc taacctttta 142141 cgtcttcttg tcgtagaggc agttgtaatt tctccgttag cctttgcctc ttctttcatt 142201 ttttcacgtt caaaatcatc cagtttctgt tggtaaaaag gtgtgggaca tggatctggt 142261 aatttttcaa tttgtgctac tgagaaatca ccaacaccag caatatgcac cctagtgccc 142321 ggagcagaag gcaaaggagt accgtgcaaa taaccataga tagcgacttt gcggtcgatt 142381 tgcagtcctt gagtctctat taattccgga tgagttaaat ctgtgaatct gtcagccaac 142441 atatagggat gttcgttcct ccattttaat ggtctgaatt tcataacaga tataaatcgt 142501 gaaaggttta aaatctctct atcaggatac cttccattaa tcacaccaga taggtaaaat 142561 aattttgcac cttgataaac ttccgtccag aatctgtgct ttaatctttt cttagaagct 142621 ctcaaagttg actgagattt aaacagatca agatgtgtag ctacaccaag tactcttggc 142681 ataccgtgat gttgagcaat atttaagaat tccattgttt ccatttcaaa accgaaatta 142741 ccgtcaatta gtaaaagaac caagtcggca atcttagcaa tatcaatcat cgcattcaga 142801 tcgtccgcag ggcactccaa aaaagttagt cttctatgtt taccagagac aacagtaata 142861 ggaccttgaa tatcattcaa agtgcttttt gtcattctcc tgacgaggga ccgaatcaaa 142921 gtagtctttc ctgttccagg tggacccacg acagcgacga taaatggagg cggatcatct 142981 tcaggggtac gatcaaccat aggaacatgc agttttcttt cgttcacatc acttgacctt 143041 tgcatagttc tcgccatctt acctggggct gccacggcaa aggcctttgc attatgaccc 143101 tgcgtatgga gcttcttttt tgctgtattc ttctccttcg ccttacggtg ctgtttatta 143161 gactgctcca tcgtttcaga taactcagat ggctgattaa aggctactat tatgtgatat 143221 ttttacctta acagcgcaaa tactttcctt aattttgaag cttcacttca gctcatcgcc 143281 ttgaaaattt ttcatttgta cggacattaa acttaggcga taacaaaaaa aaaacttcat 143341 ctagataatc tcaactttga aattacagaa atatttacaa cagtagtacg agtatctgca 143401 ctatggctca catgtcctta aaataatcta agcttaccta tctgatattt gttttgatat 143461 tgtttaggac cagcagtttc tgagagttta gcaaatgcac ctttacagct atcctcaact 143521 tttggaagag aaagtgacaa gatatgtaac aatacttgca tgaatcgaca tttgtttact 143581 ttggtccatt ttgtatatga tagtgtgatt tagcgatatg gaattatgtg tatttttcta 143641 tttgttgtca tttcaatatg ggatgacttg ttttcttgta acgcgccact tcaatagtaa 143701 acattatgaa cctgataaat gttagcagac ttagtaagag agacaatcat tttcattcag 143761 taaaaatcgc aatccctagt ttggctcttc ttctagccgt actttaaatt caaagcaaaa 143821 atggttctgc ttaacagaag gaaaatacaa cctaaggaaa taggacagtc tgctgattcc 143881 ttctctgaaa ctccatgggt gattaaagaa agtagcgagc gtataaatga ttatgacagt 143941 gatttaaaaa agctagattt ttacaaaagg gatatattca cctgtgagat tagtggaaaa 144001 gatggccttt cgtatttcaa ggcgttaaaa agcgaagaac agcaccgtga aaaggtcaga 144061 tatcttttac caaaagaact aaggaaggct atagcaaatt tcgcaaactt cagtccgata 144121 aggaaggtag gacaccttgt agaaagcgca tttcagcgtt ttagtaaccg tttctttata 144181 ggcgatacgg tgtgcttgaa aactatccaa aaaaatgcat tgattaccta taaagaagga 144241 gagcctaact tggtagaatc accaactatt gaaaacaatg tcacgttgtt ccttgtcaag 144301 gatgtgtttc aatctaacgg gatgatggaa agtgaaaagg gagaaatttc tgccccaaaa 144361 ttgtcactgt atttaatcac agaatgcctg aatcgagaat ctaaaggtgc ggccctaatt 144421 gtaggccaga atgaaattaa aaggccagaa tcacactttt ctaaattcat aattgcgtgt 144481 tttcttaatg aaatactcat aaaagtatcg aataaggagc acgcaccatg gagggtgaaa 144541 caagaatata tagaaagata tgatgtaaac cctaaatgct ctcctaatat gattgattat 144601 ttgccggata gaatgaactc atcttcttcc gagctttaca ctcctcttac tataccacca 144661 gagagcgatg ttgaacctgc tgactggaag gaaacgtcgg aaacgtcgga aacgtcggaa 144721 acgtcactat ctaaaataaa agcaattgac gacgagattt cagtctcatt tgaccacatt 144781 tacgataatg tgaactccct tgcctacaat gatttgaagg gaaccgtcga cgacaaggag 144841 cttccattca ctgggccttc gataccattt gaaaatatca gctacttaga tagctcctta 144901 gaatataaga atatcgatca aaaatggttc aaagagtgca gtcaatttcc aacggaacga 144961 ctattggttg tttatcaatt cctgagcttt tttggacgtt ttattggtct atcacatttt 145021 aattttgatc agttccttac tactatcaag tgtactagtc cggaggcttt agtagatgaa 145081 tatgtcaaaa taaactttct taaaacttac aacagcaaag ggagtttcac aaatgagaag 145141 ccaagaaacg aaatatataa tcaagtgacc agtagtaacg tatcccagcg tgagaaggct 145201 aacgtcttta atgcagatga gagtcaacga atacctagca atttcaccag aaaccagaaa 145261 atgaggaaat ttataacgga taaaagtact gaatttgtaa tgtattccat ttttaaaggg 145321 aagcctctaa aaaatgacga tatggagttt caatcgtacg aaaaagtgaa tatactttac 145381 attgatatag tttgctcgtt aatgtgtctg atgacggata atgaacctga ttggaattgt 145441 aatctgatgg acaattggac tgaagaaaag cgaaaggagg aaggaaataa aacagaaatt 145501 gatatagcta tagaaaagtg tttgaactat ggagatacta gctgggttaa acttttgcac 145561 aataaaaact ttagcaacgg caattggttg atctgtctcc ttggaatctt gcaacagaat 145621 acacatatga tagcatatag tgatgtcgca aaatgtatca caaaaaaaat actaccttta 145681 tccatgaatt ttgtaaattt aggtgatgag ctctgggata actttcgcaa gagattatct 145741 ataaaagata aaattgatgt tttatgggtt ctcgtagatt ttgcgtccaa tttctcgagt 145801 tatattaagg agttggtaga taaagtacca aaactgtgca atggaatccg cttaaagttg 145861 gatagtgcaa aaaaagagta tatcaaattg aaacggcaac taaaaacgtt aaccaaaaat 145921 cgcgtgaagc ttcacagcaa cgtttcaatg aaccgatatg gatcagatga atgtaaaggt 145981 aaggtcaatg cccttaaagt gaaaattgca tacttaatgg aagatatcgc cttcctagag 146041 gcaaaattga ttcagagcga tatcaagaga ctagagattt tgggtaaaga tagaaatgga 146101 aatcgatatt attggatgga ctcaaatgga tcgtcatcag ccatcagtga aaaaaatgag 146161 gaactttaca actgctgttt tttgtgggtt caaggaccct ctgaagcgga tataaacttt 146221 tgcttagatg tcgacgtcga atctttgaaa aaatgggagt tgttagctaa agcaaaaggt 146281 actgcctacg cgacaaaaga agtcttttca atatttaggt cgacagacgg gtcttactat 146341 caaattgctc aaggtgagaa tttcatgata attaattcaa acggtatctt aatgaggcca 146401 actattccgg cattcataga caaaaaaatt atatcagaaa ctccagaaaa gctcctactc 146461 tctcatcatc aatgggcttt cttcaacgat atagaagata tacatatgtt agtagatagg 146521 ttggatgatt taagagaaaa tgagggacaa ttgaagaaag ctttgacatc caaaatggac 146581 cgtattgaag tatcatacaa gcaacagttc aaaattaaaa ggcgtattga atgtgatgaa 146641 accttcaaaa aaaatcacaa acttttgaaa aataacgagt tcacgtttcc tgaactgaaa 146701 agaattgaga caacttgtac atccaacggc caacattttt ccaacatgga gaaaatttcc 146761 aaaaaactat caaggacaaa gaatgatctc gttttggaag cgattttaaa agacgtagct 146821 caccttggag aatgtgaaag agcacttctc aaaaagcaac aaaatttgat ttatcctttg 146881 aattttcatt tcgaacaatt gaggacgata gacctcgaat ttatagttga aacgaaaaga 146941 aaaaggcaag aggatattct tacgaagctt ttaaatcatc agaggtataa gcatattagt 147001 catgtttcag gctatgggat aagttctcaa cgagtagata aagctgcaca tcttgatgtg 147061 cagggtatat tagaggagat tgaatgtcaa cttatttcaa gacgacgaga ggatgaagaa 147121 cgcaactaga aacaactctg cagttcaaat cactcttcct gtatacgcct tagaaagata 147181 ttagaaatat cttttactat ttaatcttca ccattcatta ttcctcgtat ataaattggc 147241 ccatttcagg gcgtctgact ggagttgtat ttaggcttta cccggcgttc ttctgaattt 147301 atagccagca aggaaaacaa cgtcaaaatt ggtcctcgac tgacgcatta gtaagattaa 147361 tatttagcaa acactatgat ctccgtaaca atctcttcag ctattccaac acttgatgat 147421 gtcagtcaat agatttactt caggtcgact ccctgttttc cttagaaagt ccccttttta 147481 ctactcgaga gcttatttgc atcaaacatg tgttttcaag caaaataaag aaactgcaca 147541 agattcgcca gagcttttag caaaaagctc acatctgaat tcgaaaccac tagatgtaag 147601 caataaagca ccagtgaaaa ctgctcagaa taaaattcct ctagctcata gtaaatatga 147661 atcgtcaaag tacgaacttc ccaaatggaa agaagccttg ggtgaactag taattcgagc 147721 atttcattta gatatggata gagtgagggc agggcccgtt gcaggatctt actattataa 147781 aatttgtaaa gagcaaggtt tacaatacga ggacgagcca ttatcagaaa ctgctaaata 147841 cttttacgag gatttgaagc taccacgtac tttttcacaa tggtttcaaa tcactgtatt 147901 gcacgagtgg atactttttg tacgtatgag agccatgcct ttcaaatacg gcagaaacta 147961 tcagcagaaa ttggtagata gaacattttc tgacattgag ctgagattat tcgaggaaat 148021 gaaagttaat tctggtagaa tcgcagatca atatttgaaa gatttcaata cgcaattaag 148081 aggagcgata tttgcatatg atgaaggatt tgctacagat gatggtacac ttgcgacagc 148141 tgtctggaga aatctttttg gtggaagaaa gaacattgat atggttcatt tagagtctgt 148201 tgtgagatac atttattctc aactatatgt tctaagcagg ttatcagaca gagagtttgc 148261 cacaggtaaa ttcaagtttg ttcctcctgg ggtgaaggtc gaaaaactga caccaaagca 148321 agaggaagag ttgaaggcca agaccattgc aaaatatgaa gctctagaca aggatcctaa 148381 aaccttacca agcgagagaa gtaggctgtc atatacaaac taaacgagct agtttgtaac 148441 ttcaaaactt atgaaaacac ttatttattc ttcagatact atccgcacaa attccttaag 148501 ttttttccaa ttttttgggc tttcttcctt atttaatcag tttataaaat cattacgttg 148561 taaatagttt atttgaattt cttcaaagaa gcggaccact tttctggttt attttcatgg 148621 aataattgat ataatgcgtc aatcaattcg acatggaatg aaccacttcc ttgacaacgg 148681 gtggaagcca acttaccagc tgatttgtat aataggacag caccaaccac agcatcaaac 148741 agttttccag tggaatctaa cccaccgata aaggaagcaa ttgtagaacc aagtgaacat 148801 ccacttgcag tgatgtcacc catgatagga attgggccat cttcaattat tacacatgga 148861 agatcttcag cggttattcc ttctgttcct gatgaaagtt tgtattcgcc tccaaaagta 148921 ccatcagcaa cgcaatcaaa ctcacccgtg caaacagcaa cagtcctgta ttggaatgcc 148981 acaatttgtg tagcgcgcac aagtgtgtcg atgttcgttt tgccgctgct agagtcgacg 149041 cccttcattt tatggttatt taacttggct agagacagta tttcactgca attgcccttt 149101 atacaagcaa attggccgta agtgagcaaa gtgttgttta gacagagcct tgtttcagtg 149161 gcgctgtacc cgaccgggtc aaaggtgatg ggtctattta cttcattata agcattaatt 149221 gcggctttta gcatttcaat aggtgccact gatccggtat ttaacagtaa agaagcattt 149281 gggattcttg ctagttcaga tacttcactt tcaatttcag acatgatagg agatgagcct 149341 aaagctagag tgacattggc accaaaattt tgatgaacct tattggtgat atgttgcact 149401 aatggacgat tgtttgatac ttgagatata acgttttgaa ttgaagttgt ggtcggaaat 149461 gtattattta actcgcactc aacaaattgg tatctggtag catctaacaa gcctctcaac 149521 ctcttggttg ctgcacatgc atctggagcg gccataatat cgctgactag agagatacca 149581 tccaacgatc tctttccatt tgaagcaaca cattgacaaa gcacacgttg aatattgtca 149641 ggatgaagac caccaatacc aacggttcta caccatgtag ctttaaattc ctccaaagca 149701 tccaaaatgg caatggcgcc ttgaggaccc atgggtgatt tcttaggatt tttctttgtt 149761 gatgtaggga aaagagtacc aacaccaata taatctacca tatctggccc ccatttagcc 149821 aatgtctcta cctccgaagg tttaccaaca ctccatccaa gaattttaga agggcccaaa 149881 agttttctta ccattgggat tggcatatcg tcctggccca catgaacccc atcggcgtca 149941 attgccatag cgacgtctat acggtcattg ataataagtg gaacattgta cttcttacat 150001 attttttgaa cttctaaagc ctctgcaacg aaattttttg tttcaatatc cttttcacgg 150061 atttgaacta gcgttacacc atttttcaac ccagcttcaa cctgagaaca taaagtagtt 150121 cccggtggaa gcatggtaga atctgtaacc agatataatg agtaatcaac ttcttcctta 150181 gtaaatacca tttccgctgt ttgatttaaa taatttagct tcagagtgat ttggtcttga 150241 gaaccatggt tagatcgaaa actaggcgct tccacaagta aatggatgcg ttgccgctat 150301 aaatatatgt agtattgatt ttgttacacc tgctaaatag gttcttacga ttgccttttt 150361 cctataatat gcataaatta tgttgcccta aaagagtgaa ataaacctta tctatctttt 150421 ttttgttcct ggttttcaaa gttgattttc gacagaccct agttaattat aggaaaaagc 150481 cctattagtc tttttcttat catagatgac atttacttat attaggccaa tcgcatactc 150541 tgcatccaac aagccttcaa caggtcgaag tgaaactaca ggacttggaa aatatcagtt 150601 tttataagca ataatgaagt tcacccctag catagttatt gatgctccgc aatattatgt 150661 tgatcatttt aatggcaagt ataacgtgga taaatgtgtt attttaagag acctgcagct 150721 agaaacggat tcagaatcca tgccatccag cttaaagcat ttgaccaaac ctacgcacat 150781 cttggatttg acaaacaatg accttatcat gattccagat ctatcaagaa gagacgatat 150841 acatacatta ctgttgggcc gaaacaatat cgttgaagta gacggtcgcc tattgcctat 150901 gaatgtacag aaccttacat tatcgaataa cagcataaga aggtttgaag atcttcaaag 150961 gttgcgtaga gcgcccagga cgttgaagaa tctaacttta atagggaatc aagtatgtca 151021 tttagccaat tatagagaac atgtacttcg attagtaccg catttagaga ctttagactt 151081 tcaaaacgta acagctgagg aaagaaagag cgcaatgagc tttccaaggc aggcggacgg 151141 cgatacgttg ggcccagtaa atactgcaat aagagataat ggatccagag ataaaacgat 151201 ggagatcatg aatttggtgg tgagtaagat gacagtagag agaagaaatg aattgaaaaa 151261 gcagttagca gaagctactt ctttagaaga gattgccagg ctggaaaaac tactctctgg 151321 tggtgtttaa tcttttggtt agtgcgactg ttcaatgact taaaaaaaaa gaattataaa 151381 ttattctgtg ccattatata ataatatata aaacgaaaac aaataatggt gctctataaa 151441 cattagagga caatgtcaat ttcaatgtca atgccttaga aattaaagtt ggtaagaaag 151501 aaggaaaggg caacctaatt agctgccgct tccggttgta cttcaggttc gttgctctga 151561 gtggtgctgg atatttcagc ctttttacta gcagcttcct cctcttccat tctttttctt 151621 tgcttaatct tcttattgct ctcgggcgca tcagtaagac ctgggatacc cttagctgtc 151681 aagaattcga agatactctt ttgcacagca ggtcccgatt tatcggcagt ttcttctccc 151741 tgtgctccag taaccttgtt gaaactatca atataactaa agaacgcatt aaaaacattt 151801 tcgtccacct cttccttgta gatcttatcg tagatatgct tcattttgaa cttatccact 151861 tcgtcttgat atttggaaaa atcgatcgcc ttgtaaccaa actgttctag tcttttatta 151921 taaccttcaa atactggagc ttctaacaat aatcctaatg caggtgcctt cggaatatta 151981 atcttctgct gtccgtaagc ctgactaatg cgttcgacgg ggcaaccaca acgggtaatt 152041 aaggttgcca ttgataccat cttacgaatt tgatgtagca tgaaagactg gccgtgaatc 152101 ttgatggaaa tccattctgt ttgggcatcg ccaataacaa atggatcaga tacttttata 152161 tctttcataa atcgaatggc acttggttct ttgaagtcct tgcctaatgt aaaattatgg 152221 aagttatgag cgccaaggta ttgacttgta gaagcacgga atttggccag ttttgccgcg 152281 gatatacgat atcttctacg gtgagcattt tctaattgct tgtacttttt taccttctgg 152341 tatagttctt catttatatc aaattcatct cttgcgggcg gaacatatgc taatatagct 152401 tcgatttctt ctgttgaaaa tttttcattc gcatcttttt taaactcttc ccaaaattct 152461 ttggattcca aatcttcatc taatacacca ggtaattctg ttttactttc ttcgatgtct 152521 ctataaagta tagaaccagg tttggggcca atgagtgaat aagttggtaa taagtattcg 152581 taccaacgtg aactgcacat ttttctacaa tcaaacgcct tgttcacacg ctcgatatcc 152641 cataccctta tcccttccgg taacttttcg ttgatcttct gcttgatatc aggatcttca 152701 ataatcattt tcaatgatat taaattacct ccagcatgga cacccttatc agttcttgca 152761 gctctcatga atccattctt tttcaaatcg ttggagttgt ccttggaaat agcacctgct 152821 tcaacaaatg ctttgaatag ggcagactcg atggttggat ttggtggatt atattgcata 152881 ccatggtagc cagtaccaca gtaaccaacc ataacagcca cctttctctt tgggagacga 152941 ggctccttgg gaagtggatt gccattttca tccaaacgag gaccgctttt tggtctttta 153001 tctatgtgtt tgtcattatc cttttttttg tccttttcat cgtcgaagtc tgccttacga 153061 gctttggtca atttgctctg agcgcctctc ttgtagacat cctcattaac ttgatcgtca 153121 taggcaggcc tcaaattctc ttcagacatc cttgatatca cttataattg ttatttacta 153181 gcactttatt gtcctttatt atttttttag tacttcttgt atttcaaatt tctcgaacta 153241 tagcgatgac taaaagtgaa aaatttcaaa gccaaaagaa aaaaaaaaaa agaaaatatt 153301 atttcagcgg ctaatagtta cccgcatcaa aataatatat ctctgtacgg taatgaaaat 153361 ttttgaaata tgcgatgagc ttagaactaa agtaagcaat gtattattga ggtaattgac 153421 ggtttagtga ttggatcgta ttctagattt ccgagtagta gaaccattga gggaaactat 153481 agttaggtgc aataatgaga cagctaacag aagaagagac caaggttgtt ttcgaaaaac 153541 tcgccggcta tattggtaga aatatttctt ttttagtgga taataaagaa cttcctcatg 153601 tcttcagatt acaaaaggat agagtatatt acgtacccga tcatgttgca aaattggcta 153661 ctagtgtagc aagacctaac ttgatgtctc tgggtatttg tttaggtaaa ttcacgaaaa 153721 ctggaaaatt caggttacat attacttctt tgacagtatt ggctaagcat gccaaatata 153781 agatatggat taaacctaat ggggagatgc cattcttata cggtaatcat gtgttaaagg 153841 cacatgtggg taaaatgtct gatgatatac cagaacacgc cggtgttatt gtgtttgcaa 153901 tgaatgatgt gccattaggg ttcggtgtca gtgcgaaaag tacttctgag tcaagaaaca 153961 tgcaacccac tggtatagtt gctttcagac aagcagatat tggtgagtat ttgagagatg 154021 aagacacctt gtttacttag tgggaaggac tgatgatgaa ttcccgtgta catttcactt 154081 acagcttgcg ttatctctca caatgtattt ttttctgtat aataaagaat catataatta 154141 gcgcttaaaa ggaaagagtt gttcgataaa atggggagcc taacccctcg atgacctttc 154201 ttttgaatta gtcgagttcc atttcatata caatattaca taacttgaca acatttgagg 154261 attactaatg acaaaaatct ttatacgctc tatttacggc ccttcttctt gttcttaggc 154321 tttttattaa cagtgggctt ccctttcttt gatatgtcaa gggcctgttc tgattttttg 154381 ttcatagcac caccttgagt ttgttttgca ccttgttgtt ttttctttgg cctataagta 154441 gacctgtctc ttaatggcag ccacctttca ggatcaggta atttggaggt gtcgcgacct 154501 tgtaaaaatt tttcgaggcg tttaatcttt cttttcttct ttagctctaa aacttttctc 154561 ttttgaactt tgctaactgc ggtgttttta cttctctttg ctgacgattc taagggtttc 154621 acaccaagtt gaattaattt atcaatatca atatctctca ctagatctat accttgtgct 154681 atatccaaag aatctgacga aacaactctg tcaacaagga catctgcatc gcctttacta 154741 aagtttgaaa tctctctgag taaagccttc gattctttag cattacccat ggacaataat 154801 tcaaacccga cgtgtttcca aaatggtatg ttttcttgga tttttccgct caattggact 154861 ctcacggagc ctaatttttt aagcagaaca cttttggagt tgtttcttcc cttaatcttg 154921 tataattcaa ataaaatgta acacacgatg gcttgtgaat cgttgaattt ttcaaaggac 154981 gatttccagc tttcatttaa aaataattct cctattctga tagcattttc ccattccttc 155041 tctattatta gcaattggat agtcagtagt aatattccaa tcgtacttcc atctgttcca 155101 cttaaaatgg tttttgtagt gtggtggtaa agtttcttgg cctgcgtctt gtagctttcc 155161 aaagtaacat tgtcaactaa cttagagtat ttatcgaacg ttcttgataa aagggactct 155221 tgagagtgaa ttttgacatt gttgaacaaa cgcaggaaaa gtacattgcg ttgaatgttt 155281 gaccattgtt catgggtgaa ggtttgtaaa ttaaaagtgt ttagtttttc tacgtttaat 155341 tcccttaaca gtaaattgaa gtttgtattg tatttagaga aatcaacaaa cgcatttagg 155401 ttattttgac aaattaaaga gaatggagaa tcggctttca gttcctgcaa taagcccttt 155461 aagatttctt tactttgtgc agttttcccc accatttgca aaacaaatga taattgcaat 155521 ttaatagtat taatatcgtt ttgatagcct tcattcgtgg ctccttgaag cgctttttct 155581 aatagttcga tagccttgtc atatttacct acggatgcca tgatgaatga ttcattgaat 155641 aataaatcgt aggaagattc atccatagga gtaactaagg gtgatctgtt cattaactct 155701 gtcgcaacgg atagcggaac cctttcgtta caagagagtt caatttgact atcctgatcc 155761 ttctcattgt gacttgctaa atgttgatat attttaaaag cttcttggta cagcccattt 155821 ttataacaat attgagctct cacatgtagg atacctctaa gtgactcgat atcctttttt 155881 agtaccgtat cgagatcatc tgtgataatt gctgtgtaca atgtgttgaa ttcatctggc 155941 atattcaatt tatagaaaat gtacaatttt tctagcgcaa atttgcgacc gtacttgtca 156001 tctatatgtt tgaatttttt taaataatgt aaagcctttt gatacttgtc ctgttggata 156061 acagctacta agcaacgtct aaatacatcc gctggattct cacatccaga atccaatagt 156121 ttcacgcaag tctgttcgac ctgcgaatgc tcgtcttgag acaattgaat gttcaattga 156181 gagagcaaat tagttaaatt atctttagcc atttttttgc tttctttcat tactcttatt 156241 attgatcaga accaactcaa caaagtaaat ctgctacttt aatgcatagc aattttcagc 156301 ttgttttcct cttttctttc gacaaaggcg aaagaaaaga ggaaaaaatg aacaagaaaa 156361 tttaatcaaa tatcgcaata tacgatgccg aaaagagtaa tgaaatatta gaaatggata 156421 cttagtatta tgtgatatgt gcgggagtga ttaatagtgc ccttcaaacg attctgtcat 156481 actttaattc tataaccgct tattttccca aaagggcttg tttcttagta tccaaggatg 156541 catttttacg tctccaaggc gcattctatc tttggggtcg tattttagta gtttaagtat 156601 taaatcttgc gcatcctgag aaatgttact gggcattttg atatccagtg ctgctatcct 156661 tttatatgta gtatctttca tttcttcttc gaacggaggg gcaccggtca gtagttcaaa 156721 cgccaggacg ccaagagccc atgcatctat agtgtgatca tattcccttg actccaccat 156781 ttctggagaa aggtagtcaa ttgtcccaca gacagttttc cttctatttt ctggcggatt 156841 tattatactc catccgaagt ccgttaactt aatgacatta ttgaacccta ttagtatatt 156901 ttcaggttta atatctctat gaataatatt ctttttatgc atataatcta gggcattggc 156961 aatttgataa atataatctg atgctaaaat atcgttgaag ggtccgtgta acctcaatag 157021 tttatacatt tccccattga ctaagtattc cattagcagg tacactcttt tttcatcatg 157081 aaaatagccg tatgatttag ttagattcgg atgatttagc gatgtttgta tttctacctc 157141 ccttctgaat tgtttctgta aattatactt tattatttct tccttctcca ttactttcag 157201 tgcgcaaata tatcctgtac tcctgtgccg aacgcaataa actttaccga atttaccctt 157261 tcctaatttc ttccccagtt caaagtcatc gagtgatagg gatttaaatt taggtagctt 157321 cttattttcg tgtatcattt tggaagaagt cgctttcctt ataggtgatg gaattttgga 157381 gctttccata tccaaaaact tcttattgtt tacaggtaat ctgttcaatt tttctcttac 157441 aggtgaaggt atttttgaat tcgggtttct ttgctgcggc gaatgggata ttctccatgg 157501 tttattgatc ctggacgtat ttggtcttgt tgtggtcttt ttcgatggcg aattagcgtt 157561 tagtttgata tttactaaac tattgcgttg cattcccttt ttacttcttt cttttgttgt 157621 atttcaaaat cccagttttt tttgcgctaa gaatgatctt gctttgttta tgcattcact 157681 tgagcaattg catcagttgg ccttagctca aggtttttat agaatggtaa acaaattaag 157741 cgctttacag gaaaaacgcg tgaagttaaa cttactgttc aataagcaat gctgtatcgg 157801 aaaatggagc acaaaggtta tagatacaag agaagactat catgtcatca gatgcgttaa 157861 aagcactact tcagtggggt gcgtcatttg gtgtaatagt gccagaggaa ctcaagtttt 157921 tatataccga tcttaagggc attatttgcg tatgtgaaaa agatatagac aatcccagca 157981 tcaagattcc tcccgagatt gtcatttcaa ggaatctgcc catgaagttt tttgggctaa 158041 gtgaatccac taagaatatc aacggatggc tgaagttgtt cttcgcaaaa ataaaatttg 158101 atagggataa tgatactatc gtggacaatg ttcgtgtgaa tgataaattt aaaccttact 158161 tggatgcatt gccttcccgc ctaaattcgc ccttggtctg gaacccaagc gagttgaagc 158221 gtttatcatc tacaaacata gggaattcga ttcatgaaaa gttcgaaggt atatttaaag 158281 agtggtttga actggtcagt tcttcagata tgtttgactt ggaaagagtg gcagatgatg 158341 tgcagacctt ccataatctc gatgagttga catatgaggc tttgtatgag aagattttga 158401 agataacaga acttcaaaga ccaactatct ggtattcttt tcctgcattt ttatggtcgc 158461 accttatatt catttcaaga gcattccctg aatatgtgct aaacagaaac tgtcctgaca 158521 actctattgt actgcttccc atcgtcgatc ttctaaatca tgactaccgt tccaaagtca 158581 aatggtatcc tgaaaatggg tggttctgtt atgaaaaaat cggtaccgcc tcccaatcac 158641 gagaactatc aaataattat ggcggtaagg gaaatgagga gttactctct ggatatggat 158701 ttgttttaga agacaacata tttgactcag tggctttgaa agttaaattg ccattagatg 158761 tggtatctac aattcttgaa acagaaccta gtttgaagct gcccttactt tcggattaca 158821 ccacttatgc ttttgaaaac aaagactgtg tccagcaaga aaagaaggct actcgtagtg 158881 ctacagacta catcaatggg gtgacttact tcattaacat acaaaatgaa caatgtttag 158941 aaccattact ggatcttttt acctaccttt ctaaggccga agaggaggat ctacacgatt 159001 tgagagcccg tttgcagggt atacaaatgc tacgaaatgc attgcagagc aaactcaaca 159061 gcattactgg accacctgca actgatgact cttatgcaat tgatccttac agagtctatt 159121 gtgctgacgt ttatactaaa ggtcaaaaac aaattttaaa agaggcttta acgaggttga 159181 aaaaactaga aaaaacaatg ctgtcagaga acaagcacca attgctaacc atgagcaaaa 159241 ttcttaagaa tgaccctgct tttgcagaaa ctgaattacc ttcgctgttc agcaacgaag 159301 atggtgaaga ggtcatcttt gaatctactt atgatttatt gatactttgg attctactga 159361 aaacgaaaaa gaattcttac cccaccaaat atgaatgggt tggacagcag tatactaatt 159421 tcaagcaaac tgcatatatt tcagatgatg ccaaggcttt ccatactgca tacttcgaga 159481 agcaagacga tgtggatttg gccgaagtag atcatgcgat tcagtttgta gtagacaatt 159541 cctttaccag aacttcatct acaaccgaag agactatttt agtacgtaag tagcttttcc 159601 ttatagaatg ttagagtaga gtacgtaatt acatctgcac ttatttaata aatgcactta 159661 ctaacaaact gggttctcat tggtcagaag tgtcccgggt atccgaatat ggcttcgatg 159721 aaatttttcg ccatggagct gcgatgcccg atatttgtgt ataaaacatg gaaatgagct 159781 tatatagtga ctactctgca ttttcgttat ttctagagca gagcttaagt tacccatagt 159841 tatttctata gcttgcccta tcatccattt gatcaacaat agggaataac tgtaacagta 159901 agtaaattat ggatggtttt cgtgtagctg gtgcgttagt agttggtgcg ttaaccgctg 159961 catatttata ttttggcgga aggttttcga tagcgctggt cattatagta ggttatggta 160021 tttattgcaa tgaagccagc ggtggtagtc aagatagtca agagaagctc gatttgaaca 160081 aacaacagaa aaagccatgt tgcagtgata agaagattgc ggatggagga aaaaaaactg 160141 gcggatgttg ttctgataag aagaacggtg gtggtaaagg tggaggatgc tgttcctcaa 160201 aaggtggaaa gaaagggggg tgttgttcat ctaaaggtgg aaagaaagga ggatgttgtt 160261 cctctaaaaa gaatattggt gacaatgaaa atactgccac tgaagttgag aaagccgtaa 160321 attaccctgt tactgtggat tttacagaag tttttaggaa gcccactaag aaaaggtcga 160381 gtacccccaa ggttttttcg aaaaatagct cgtctaactc tagagtaggt aaaaaattaa 160441 gtgtttcaaa gaagataggt ccagatggat tgatcaagag cgcgttgact atttcgaatg 160501 aaacgctttt gagttcacag atctatgtgt tatatagttc cctgcaaggt gcagcttcga 160561 aagctgcaaa gagcgtttac gacaaactaa aggaattgga tgaattgact aatgagccaa 160621 aacttttgaa ccttgacgat ctatccgatt tcgatgacta ttttataaat gttcccgttg 160681 aaaatgcatt gtatgtgctt gttttaccgt cttatgatat cgattgccct ctagattatt 160741 tcttacaaac tcttgaagag aatgcgaatg attttagagt agatagtttc ccattacgaa 160801 aattggttgg ctacacagtt ttggggcttg gtgattcaga atcatggcct gaaaagtttt 160861 gttatcaagc caaaagggcc gatcactgga tttctcgttt aggtggcagg agaattttcc 160921 ccttaggcaa agtttgtatg aaaacaggag gtagtgccaa aatcgatgag tggacatcat 160981 tgttagcaga gactttgaaa gatgatgaac caattattta tgagtatgat gaaaacgcag 161041 actctgagga agatgaagaa gaaggtaatg gtagtgatga attaggcgat gtagaagata 161101 ttggtggtaa gggtagtaat ggaaagtttt caggcgcaga tgaaatcaaa caaatggtgg 161161 cgaaagacag tccaacgtac aagaacttga caaagcaagg ttacaaagtt attggttccc 161221 attcaggcgt taagatctgc cgatggacta agaatgaact acgtggtaaa gggtcttgtt 161281 ataaaaaatc gctcttcaat atcgcgtcca gtagatgcat ggaattgact ccttctttgg 161341 catgttcatc caaatgcgtt ttctgttgga ggcatggtac aaatcccgtg tcaaaaaact 161401 ggagatggga agtagatgaa ccagaataca ttctagaaaa tgctctgaag ggacactatt 161461 ccatgatcaa acagatgaga ggtgtgcccg gtgttattgc agaaagattt gcgaaagcgt 161521 ttgaagttcg tcattgtgcc ttgtctcttg tcggcgagcc tattctttat cctcatatca 161581 ataaatttat ccaattatta caccaaaagg gcataactag tttccttgtg tgcaatgccc 161641 aacatccaga ggccttgaga aatattgtta aagtaacaca attatatgtt tctattgacg 161701 cacccaccaa gacagagctg aaaaaagtgg atagaccttt gtacaaagat ttctgggaga 161761 gaatggtaga atgcttagag attttgaaaa ctgtacaaaa ccatcaaagg acagttttca 161821 ggttaacttt agtgaaaggt ttcaatatgg gtgatgtcag tgcatatgca gatctggtcc 161881 aacgtggttt accaggtttc attgaagtta aaggcgccac gtttagtggc tcatctgatg 161941 ggaatggtaa tcctttgaca atgcagaata ttccatttta cgaggaatgt gtaaaatttg 162001 tgaaggcgtt taccacggaa ttacaaagac gtggattaca ttacgacttg gctgccgaac 162061 atgcgcattc caactgttta ttaattgcag acacgaaatt caaaattaat ggagaatggc 162121 atacacatat cgattttgat aaatttttcg tattgctaaa ctcgggcaaa gacttcacgt 162181 acatggacta tttagaaaag acacccgaat gggcattgtt tggcaatggt gggtttgcac 162241 cagggaatac aagagtgtac agaaaagata agaaaaagca gaataaggaa aatcaagaaa 162301 ctacaacgag agagacgcct ctccctccta ttcctgctta aaagatactg gtatatatta 162361 agagtaatat cacgtatata tatatatata tatatattta ttcgaaataa agagcagaac 162421 aattcaagtg ttcaattagt atgaatggct attaacatta tcgtttcttt ctttttttat 162481 gatttagtcc aaaatatcac tattcaaatc tcgcggagag aaagggttcg aaaattttgt 162541 tttataatat catgattttg atacgaacat aaatatatat agaagtaaaa gagaaagtgt 162601 tcagaataat attcacgtca atgaatggat atcaaagaaa atgaatggtt cgaaggaaca 162661 aaaaaatcac ataagcaata gaccaaccgc acaacttaat atggacccat ttggaatata 162721 gaagcgtgca aaggatgtta taaactttga taaaagcatg gaatcttagc ccatctacag 162781 atgccagact gggcgcaaca aacttttttt cagcagtagg cttcttcgcc acggtatgac 162841 catcgcataa ctttcttgcc ttgatcggat catccgtgat agcaccatgg ataggcaatt 162901 cgcacagata tttgaaatct ataggtttgt tgacagtcca taaatagacc ttgatatcat 162961 tcttcataag cacaggtagt aatctcaatc taaattggct tgtccacgag gagacaaaat 163021 ggacgctgat accaaaaagt ttatagtgag gatcattcag tgtcaaagag cgcttcacaa 163081 attgcgaggc gatatctaaa gacagactta tcacaataac tttgaaatcc ttcagaacac 163141 cagtttcaat accgaaatcg taccaatcca gcaaccaaag cccccacgtg atcctctcct 163201 gccaaaattt aagatcattc ttaacctcta acatgataac aaaggtcttg atcatgatga 163261 ttttctcgtt ggtaaatttg atgtccaaca tcaatttagc tcctggatgg cacactgccc 163321 atgttagaat ttccttcaat gtcatcattg ctaaggaacc atcctctttg cagcgcaatc 163381 gcttaacctc ctcccaagtc gactcgccaa tcaccaagtt cttatcccac atccgaccag 163441 tgtctgagtc atggtttacc accaccatac catcgctggt catttgtaaa tccgtttcta 163501 ttacatcagc acctgctgca taagccttct caaatgctag tagcgtattt tcaggatatc 163561 ttgctttaaa agctctgtgg cccacaattt caaccatcct cgtgtccttg ttgttatctt 163621 acacttctta tttatcaata acactagtaa catcaacaac accaatttta tatctccctt 163681 aattgtatac taaaagatct aaaccaattc ggtattgtcc tcgatacggc atgcgtataa 163741 agagatataa ttaaaagagg ttatagtcac gtgatgcaga ttacccgcaa cagtaccaca 163801 aaatggatac catctaattg ctataaaagg ctcctatata cgaataacta ccactggatc 163861 gacgattatt tcgtggcaat catataccac tgtgaagagt tactgcaact ctcgctttgt 163921 ttcaacgctt cttcccgtct gtgtatttac tactaatagg cagcccacgt ttgaatttct 163981 ttttttctgg agaatttttg gtgcaacgag gaaaaggaga cgaagaaaaa aagttgaaac 164041 acgaccacat atatggaacg tggttgaaat acaaagagaa gaaaggttcg acactcgagg 164101 aaagcatttg gtggtgaaaa cacatcttag tagcatcttt aaacctctgt tgggtactta 164161 gaaaaatatt tccagacttc aaggataaaa aaagtcgaaa agttacgaca tattcgacca 164221 aaaaaaaaaa ccaaaaagaa aagatatatt tatagaaagg atacattaaa aagagatgga 164281 cttaagagta ggaaggaaat ttcgtattgg caggaagatt gggagtggtt cctttggtga 164341 catttaccac ggcacgaact taattagtgg tgaagaagta gccatcaagc tggaatcgat 164401 caggtccaga catcctcaat tggactatga gtcccgcgtc tacagatact taagcggtgg 164461 tgtgggaatc ccgttcatca gatggtttgg cagagagggt gaatataatg ctatggtcat 164521 cgatcttcta ggcccatctt tggaagattt attcaactac tgtcacagaa ggttctcctt 164581 taagacggtt atcatgctgg ctttgcaaat gttttgccgt attcagtata tacatggaag 164641 gtcgttcatt catagagata tcaaaccaga caacttttta atgggggtag gacgccgtgg 164701 tagcaccgtt catgttattg atttcggtct atcaaagaaa taccgagatt tcaacacaca 164761 tcgtcatatt ccttacaggg agaacaagtc cttgacaggt acagctcgtt atgcaagtgt 164821 caatacgcat cttggaatag agcaaagtag aagagatgac ttagaatcac taggttatgt 164881 cttgatctat ttttgtaagg gttctttgcc atggcagggt ttgaaagcaa ccaccaagaa 164941 acaaaagtat gatcgtatca tggaaaagaa attaaacgtt agcgtggaaa ctctatgttc 165001 aggtttacca ttagagtttc aagaatatat ggcttactgt aagaatttga aattcgatga 165061 gaagccagat tatttgttct tggcaaggct gtttaaagat ctgagtatta aactagagta 165121 tcacaacgac cacttgttcg attggacaat gttgcgttac acaaaggcga tggtggagaa 165181 gcaaagggac ctcctcatcg aaaaaggtga tttgaacgca aatagcaatg cagcaagtgc 165241 aagtaacagc acagacaaca agtctgaaac tttcaacaag attaaactgt tagccatgaa 165301 gaaattcccc acccatttcc actattacaa gaatgaagac aaacataatc cttcaccaga 165361 agagatcaaa caacaaacta tcttgaataa taatgcagcc tcttctttac cagaggaatt 165421 attgaacgca ctagataaag gtatggaaaa cttgagacaa cagcagccgc agcagcaggt 165481 ccaaagttcg cagccacaac cacagcccca acagctacag cagcaaccaa atggccaaag 165541 accaaattat tatcctgaac cgttactaca gcagcaacaa agagattctc aggagcaaca 165601 gcagcaagtt ccgatggcta caaccagggc tactcagtat cccccacaaa taaacagcaa 165661 taattttaat actaatcaag catctgtacc tccacaaatg agatctaatc cacaacagcc 165721 gcctcaagat aaaccagctg gccagtcaat ttggttgtaa gcaacatata ttgctcaaaa 165781 cgcacaaaaa taaacatatg tatatataga catacacaca cacatatata tatatatatt 165841 attattatta tttacatata cgtacacaca attccatatc gagttaatat atacaattct 165901 ggccttctta cctaaaaaga tgatagctaa aagaaccact ttttttatgc atttttttct 165961 tcgggaagga aattaagggg gagcggagca cctcttggcc aatttgtttt ttttttatgt 166021 aataaagggc taacgatcga agatcaatca cgaatattgg acggttttaa aggagggcct 166081 ctgagaagac agcatcaatt cgtattttcg ataattaact tgccttatag tgtctgatta 166141 ggaaacaatc acgagacgat aacgacggaa taccaaggaa gtttgtgcaa atatacagcc 166201 ggcacaaaca gcagcttcac tcaggttaac tcacatactg ttgaaaattg tcggtatgga 166261 attcgttgca gaaagggctc agccagttgg tcaaacaatc cagcagcaaa atgttaatac 166321 ttacgggcaa ggcgtcctac aaccgcatca tgatttacag cagcgacaac aacaacaaca 166381 gcagcgtcag catcaacaac tgctgacgtc tcagttgccc cagaaatctc tcgtatccaa 166441 aggcaaatat acactacatg acttccagat tatgagaacg cttggtactg gatcttttgg 166501 tagggttcat ttggtgcgct ctgttcacaa tggtcggtat tatgctataa aagttttaaa 166561 gaaacaacaa gttgtcaaga tgaaacaggt tgaacatacc aatgacgaac gacgtatgct 166621 aaagcttgtg gagcatccgt ttctgattag aatgtggggt acgtttcaag atgctaggaa 166681 tatctttatg gtgatggatt atatcgaagg tggtgaactt ttctcgttac tgagaaagtc 166741 acaaagattt cctaatcctg tagcaaaatt ttacgctgcg gaagtcatac tggcattaga 166801 gtacttgcat gctcataata tcatctacag ggatttaaag ccagaaaata tcttgctgga 166861 tagaaatggc cacattaaaa taaccgattt tgggttcgcc aaagaggtac aaactgtcac 166921 atggacgctt tgtgggactc ctgattacat tgctcctgaa gttattacca caaagccata 166981 taataagtcg gtggattggt ggtctctagg tgttctaatc tacgaaatgt tagctggtta 167041 tacacccttt tacgatacta ctccaatgaa gacgtatgaa aagattttac aaggtaaagt 167101 agtatatcca ccatattttc atcccgacgt cgtggatcta ctaagcaaac tgatcactgc 167161 agatttgaca agaagaatcg gtaatttaca aagcggttcc agggacatca aagctcaccc 167221 atggtttagt gaagttgtat gggaaagatt gttagcaaag gatattgaaa ctccatacga 167281 gcctcctatc acatcaggta tcggtgacac gtctttattc gatcaatatc ccgaggagca 167341 gctagattat ggtattcaag gcgatgatcc atatgctgaa tactttcaag atttctaagt 167401 tccatgaacc aaaaaacaca aaaacaattt tcaagtactt tctctcactc cttttccttt 167461 ctcttttttc ctccaccaaa atctggcgca ctttctttat attttaccta acggatgcct 167521 tatttgtggt ctgttttaag ctagttcata ttgtaaaaaa agaaaaagag atgagaagaa 167581 caagcgttgc cctaaatatc ttctatacta caattcattt taattcaata tcatatttaa 167641 gttgagggca tttagatctt agagattcat ctaaaaatag gaggggtgat gtatagaaaa 167701 tgttcgaata tcattcctct gcttttttct atatgattat ttcctatatg agcttttact 167761 tactgatctc atgatctcag tgcaaaaatt aggggaccgg cacgcctgaa agttttttag 167821 ataattgaat gttgcggtgc attacctatg aaaagatgaa gcgcacgtga accatattat 167881 aatcaacaaa cttgaagaat aaaacttttg agcgcatgaa gccatgatat atcttatttg 167941 tatcgacatg ctttaagtcc tccgtagctt taaaaagtct aaggtccaaa atccctcgat 168001 ggtgctgata tcaccattat tcatgtccat cagatcttgt cacatattta aacgtgatac 168061 cgttttaatg agttgaaaac taaataatta atattttgat attaaggctg ggtcaataga 168121 atttaattca ttaaaatgct catcgttgaa atgaagcaac gcttcgtagt tgtagtttaa 168181 catgccaaaa ttttcgtttc tctctttgcc taagttcgta gcaatatctg tatcagcagt 168241 tggtgcgttg cttttggtat ctttggaaac tttaatgatc tcatctccat aaggagcgtc 168301 tgtttccata aaatttggtg aagatgttgt tgattctgac agggctatat ccattttgct 168361 ttgtgacaag ggcctcgttg gtgttgaagg aagtatacaa gaagaggacg aaggacctgg 168421 tgtaggttct gtcaaaagtt ccatcaggcc ttggttgtaa ttttggatga aattgtcgtt 168481 gcaaaacatg ttcgtaaaat caatttcgtt taagttcgtt aaagaatctt ctttctctat 168541 ctttacacag gaattccgcg ttttgaaatt gtctaaaaat ccggtatcat gtagatccgc 168601 atccaacttc gttttcaacc ttggcctagg tttcgaatta tccatctgtc tggattttat 168661 tttagaaacg gagtttttat ttgttttgag caaatttttt ttagacgtca aaggggggtt 168721 tgatagtggg agaaaaatgt tattgaaagc ttcaatttcc ttggttaacc cacagtcaca 168781 agaaataatt ggtgtgacga gtggtaagtt tagacttgct ttatattcta attcatcaaa 168841 tgttttgatg gctttttcgt cgttcttctg acgaagattt tccttaaact ttttatagtc 168901 atccgtttta gtaatcaaat caaatctcag ctcatgtgaa tgtatgttat tcataacaac 168961 cacgttccac ttctgtaacc gcacagagta ggctgctcta attctaaatg gacatgcatg 169021 ggatcttgaa gaggaacctt tggatttagg gttcaaccct actttcgatc gtactgacct 169081 acacttaaaa gtaactttgc tactatctga tctttcgatg actatatcta ttccttgagg 169141 atagaatatt ttctgtagcc acggtttaat ctcgtgcctg tcctcaaaag acggaactgg 169201 gtctaaatga ataagtttat tttggtcttt agacatcata gatgctagat tatcgggaga 169261 tgctgttaac ttcattttcc ctgttttaga cactgatatt ggcacagata ttatgctctt 169321 catcgacttt gctttcattt cttgggggtc gctttctctt gattaatttg cgccagagtt 169381 tctggtcact acaacaaatt ttttgaatga gtcgtgttca ctattatgta taggtccatc 169441 agtttaattt gcacagtttt tgccttaatc aaaagaaaat caattctgac taaaagaaag 169501 ccactttacc gatctcggcc cacgaaacga tttttttttt tacggtgctt ttttctttct 169561 tttttttgtt ctttctattt tttccctttg cttttcgcac aataccgctt accgtcaatc 169621 gaataatgaa tggctctggt atcgttcaat aaaatgagaa acgtgcttcc agttcaaaac 169681 caaacagctc agacaggtta aagtgaagaa gttgagatat atacaaatta atgtcactgt 169741 tatttttttt atttacattt ccttaacctt tatttaagaa gaattgtttg aatgttattg 169801 tcatcagtaa gaattgtcag cactgggcta tttacagagg gacagttacc aacaaagaga 169861 tctttgacac tccttatacc gtatttggcc ctaatgtctg agtagcccac gaacagccac 169921 cgtttgaaag atatagagta cttgtatacc gataacgctg ttccgtagag atgttgctcg 169981 gttataaaaa tatacttccc attgtttgct atctgacgtc ctgttcctga agcatggaca 170041 tgaagttctt gtgtcttgta aaatattgga taaacctcgc tgtctgagac gggtggagaa 170101 gaatttgaat tctctatggg gtctcttgtt ggaatggaca gatatctcat gttggtttcg 170161 agtaaaatgt gattcgtttt aagaagatag tcgatctttt gaacgtcttc gtctatttta 170221 agcataaagt ttatttcctt gtttagcgtg gaagcatccg atcctaatag attcttgcag 170281 tggaaaatca tatcatttcc tttgtataaa gtaaactgag ggaaatttaa aacggacttg 170341 acatttgtgg tcgtgcgtag atctacaggc aaatcaatgt tggtatggaa actttgaaaa 170401 cttccattgc tttgttggtg atctaaagaa gttattagca gcccatcttt caaactaaaa 170461 gaaacaacga aatgtggcaa caaacctgcc cagacattta atatagatag gtggctttga 170521 tgagaggaag ttgaaggatc cttcaaaagc aagtgattgt ttacgtttcc gttcaagtcg 170581 cagtttagct ttaacaactt tccattctga aatccaacta aaatttgaat ggtgtttgaa 170641 ttataaccaa aattgcagtc catacatatt attgcgtccg atagcagtaa attcaactgc 170701 ccgtaaaatt gctgcttaat aaaaatcaaa tgttggccgt taaagtcata cagcagtaat 170761 tttttgtcct ctgcttgatt agaataaaaa atccagtact tgctattgaa atttctaaaa 170821 cttttgaaac tttgtaaatc gtgggtagta aaatagttat taatccgtac aaattccaac 170881 ccacggttac ttcgaaaaac atcttcaagt tccttttctt cgtcaccatc atcgtcttct 170941 tcagaatagt ttccaacatc tccaccatcc tctccgacat tgctaaaggt aagctggtcg 171001 atatgttcct ttatcgtatc tggaagctgt gggtaatcat tattcaccgt gtagttgcca 171061 tacttgctcg cccgttcgtc aaatacgttc tgatatctcg tgtggtaaaa ttgcaccccc 171121 ttcccatcct ggtatatttg cataggtata cccatgattt cgttatgatt attttctttc 171181 ttgagggtgt ttagcaatac attattatcc ttgtgatttc gcttatacac atgtaggatt 171241 tcctccttat atattacaag tgtgtcacca tttccggccc accaatagcc gccgacctcc 171301 aaattacccc aaataaaaaa aaagaaaact ccggaaatgc ggggttgagc tgcaatataa 171361 taataatatg gcaactttag ccgcgcaatc gaagatacag taaatatagt aaaaacgtgt 171421 ctgcaaatgg ctactttcga tccttcttcc caaaaggcaa tattgcagaa gaagaactag 171481 aaaatgatgg atggttccat aacaaggaag gtaacatcaa cgttgtccaa ccaattggcg 171541 acctggaaat ggaaactgca gttatcgtta ttggaaagaa aattagcgac aataaacaat 171601 gattattttc tcctgcaatg ggaactcctt tttataacta atgaagtgat gaaatggaaa 171661 gaaatgattg cctttttgga aagccagtta ttttgcacaa cgcaaaattt cgtggcacaa 171721 gagacacatg acagggaaac ctttcaaagc ctggtagatg attataacaa acagttgagc 171781 gaaaataacc tgattatttc tgtattgaaa agtagaccac agctatcatc atttcctata 171841 tatttgagcg atgaggtgtg ttcacacctt aaattcgtca tcgcggaact aaattcattg 171901 ataatagttt tttttatttc tttagtattt ttgtgggtat cgatagaagt ttaaactttc 171961 aataagtggc taatgatttc gcatttatta ctataaaaaa aatacagtct taggattatt 172021 ctctatttat cctcacgcca aactttgtat acaattacaa aagattttga atatactagt 172081 caaagtacta tctttgttgt cattgccact gttattataa ttctgagctt gaccttgagg 172141 ctgtcctcca ttgttgttat attgaggatg tggttgtgca ttgtactgat tagtgggggc 172201 attcactgcg gggccatcca tctgcatttg cacaccttgc aactcaagca ccaagactcc 172261 tgaatttcct ttttccaaat ggtttctgat accatgctta gcacagaact cctcaattga 172321 cggtttgagt ttcgctatac cgttttgaga atgcaaccct tttccaacaa taacgttcag 172381 ttgtggttca ttatgatcaa tagcgaattt gattcttttt tggagaataa atagggcctc 172441 ttttacgtat aatccatgta agtcaatttc attactggaa gaatcagcat tgttctctac 172501 aaacacatat tctgccgctt gcatgttaaa atcttcagcg gttttcagtt gtgccttact 172561 tttctcgctt agttcatgag ctagcttctt gtcaccttgt tgataagcgg tttgcgattc 172621 atggctgagt tggtctcttt tcttatacgc ttcatctgct aatcttctca atctttgata 172681 ctcttcatca gtgctatgat tgtagtccct tacaggattc tgagttccga ctactactcc 172741 acctgttcct ttcatagttt taagtgcggc gctttagctt caaactgact catggttgcg 172801 taaaaacatg gttgcttttt gtcgttttcc tcgaaaggct ttaccttttc attaagccgc 172861 tccattttaa aatgttttaa taaatccact tttttccggc gcataatgga tccagaaagg 172921 aactggcaac taaatccgta catttctgaa attatttcag ttcgcagatt attttctcag 172981 ttttaccgta tattcttatg tattacagtt gaggtaccca cacgcgcact tgaaaagtat 173041 ataaaagtga aatatttcag agctcttcct attgcttttt caatagaggc ttaaatcttc 173101 ctcgtttgta gagtaagtag acccatatta caaatctcca tcaacgtcat aatgtccact 173161 gagtatgtca aaaactacaa atacgacctt atttggtaac tagtttgttg tcggttacat 173221 ctgaatttga agtacccaaa ttgataatac ttcaggaaaa gttaacgcac attcaaaacg 173281 tgttttttta caataaccta tggtgatcga acctaattat aaaaagaagc acttgaagta 173341 gtttatcttc ttcaagtacc tttcgtaggg gattttcatt tttaatgaac aaaggcattg 173401 tttgttagta tctattactt gtaatacacc gataatttca ttgatagata tttccagcat 173461 gtctctgcat ctcccttcca tcgaatgaaa agtggtgttt tcaattcgat gtaactgaat 173521 ctttgttctt aatatgactt ctttgctaac atttttttca tttttgaata gaaaaatctt 173581 gactcctgaa tctcaattga agaagactaa agctcaacaa aagactgcag aacaaattgc 173641 tgcagagaga gctgcccgta aagccgtatg ttcatttacc atgtttgaaa gatattatat 173701 cattcctttt acagtgagtt cacaaaaata taatactttg ttaaagagat cttttctcgg 173761 ttttacattt ccttggcatt tgttagtcgc gaacaatttt cactttttgc aacgtttttt 173821 ttctttctta atgatgaaaa ctattcctta ttctcgacta gtctttgaca atgctgtcgt 173881 ttaatcacca tctttcggct gactagtaaa gaaaatgcaa gagtgagaat atgccaagaa 173941 tctgcaagat tgagttaagt tttcttagaa agttttatcg tgcatatttt tcactaaatt 174001 ggaatgacgt taaaaccaaa agtactgatc ttactaacat taatcaaaaa ttcttgatga 174061 atattatttt aggctaacaa ggaaaaaaga gctattattt tggaaagaaa cgccgcttac 174121 caaaaggaat acgaaactgc tgaaagaaac atcattcaag ctaagcgtga tgccaaggct 174181 gctggttcct actacgtcga agctcaacac aagttggtct tcgttgtcag aatcaagggt 174241 attaacaaga ttccacctaa gccaagaaag gttctacaat tgctaagatt gacaagaatc 174301 aactctggta cattcgtcaa agttaccaag gctactttgg aactattgaa gttgattgaa 174361 ccatacgttg cttacggtta cccatcctac tctactatta gacaattggt ctacaagaga 174421 ggtttcggta agatcaacaa gcaaagagtt ccattgtccg acaatgctat catcgaagcc 174481 aacttgggta agtatggtat cttgtccatt gacgatttga ttcacgaaat catcactgtt 174541 ggtccacact tcaagcaagc taacaacttt ttgtggccat tcaagttgtc caacccatct 174601 ggtggttggg gtgtcccaag aaagttcaag catttcatcc aaggtggttc tttcggtaac 174661 cgtgaagaat tcatcaataa attggttaag gctatgaact aacattattc cgtgtggcaa 174721 taatctcaat gtataataaa taatatttct cttcatatat atgaccggac tcgtaataga 174781 ataattgact ggaacaatag cgcatattgc tttgcttcta tacgtagttg agttttcact 174841 cacgtacagc tagagaatct cacataggag tatccctgta gttagttccg cgcggttcga 174901 tcacggatat actttcaaca atggcagtat gaaagcctgt tataaaaaag aaggaaacaa 174961 taaacgaagt gcttttttgc ctcctaaatt attcaatttg acaactgatt tccagccatt 175021 cattattcag tgaggagcga caatgtttgg agtcaaggat gctatattca agattaaacg 175081 ttccattgca ggcacagatt cttctgattc cactgcttac acaacggcaa gtgaatcttc 175141 acctcaatta aaagattccc ataacccctt tcgaaataaa acgacatccg agagaactat 175201 agttgaggag ggctctctac caccggtgag attgaatggc tacttgccct caactaaaaa 175261 taaacttctt actcctgaaa tgtgcgatga aataagaaca ttaatgccca cgaggataca 175321 gttgtacacc gaatggaacc ttctatatag ccttgagcaa catgggtctt cattacactc 175381 cctgtatagt aacgttgctc cagatagcaa ggaatttaga agagtggggt atgtattagt 175441 aataaaggat cgtaaaaacg gaatctttgg agcttacagc aacgaagctt ttcatcctaa 175501 cgaacatagg caatacacag gaaacgggga atgttttcta tggaagctgg ataaagtacc 175561 tgatgttaat atatccgaaa aagaagaatc tgagcaagaa ggtaaagaag gtaaggagga 175621 aggggataaa gaggagagat ggaggttttc aggttatcct tacactggag ttaacgaatt 175681 tgctatatac tgtacatctg aatttctttc aatgggtgca ggtgatggtc attatggtct 175741 tttatgcgat gacggcctac tccatggtgt ttcaaaccct tgtcaaacat atggcaatga 175801 agttttgagt aaggagggca aaaaattttc tatagtagct ttggaagtat ggcgtgtagg 175861 atagtgtcat ctatttaaat atcatactat gtatttatga atgagaacct catgattgta 175921 aacgagaaac actcctttaa atagcctaaa ccgtatcctc agtaagaaaa actagaaaat 175981 acggtcctaa tacttgcatg tgttttatga gtgacgaaat aaataggaaa agaaaaatat 176041 tttaatacaa actatcattt attgaaatgc tctttttcat tttcttcatt aaatcattgt 176101 atgcaggctg ggaaaaacaa ccttgcaatc tcccaatgtg aaaaaaaaaa gaaaatgaag 176161 atacgaacat acctgaagtg ggaaaggcag ttgccacaac cagaagagca taacatattg 176221 tcatgacctc tttatatgca cctggggcgg aggatattcg gcaaaggtta cgtccttttg 176281 ggtttttctt tgagaaatca ctaaaggatt tgattaaggg tattaggtct cacaacgaaa 176341 caccagaaaa actggatcaa ttctttaaac aagtattaag tgaatgccgg gaagaagtga 176401 actctccaga tctaaattct aagaccaatg ccgttcttaa attgacctat ttagagatgt 176461 acggttttga catggcttgg tgcaactttc atatcttaga ggttatgagc agtaataaac 176521 ttcaacaaaa acgtgtgggg tatttggctg catcacaatc tttttacaaa gattctgaca 176581 ttttgatgct tgcaactaac ttgttgaaaa aagacttaaa gtatgacgga aacaatgatg 176641 ttgttaaagt tggcattgct ttaagtggtc tttccactat aattacaccc tcattagcaa 176701 gagatatagc tgatgatttg ttcactatgc taaacagcac aagaccgtac ataagaaaga 176761 aggccattac cgcactattt aaagtttttc tgcaatatcc agaggctttg agagataatt 176821 ttgataagtt tgtttcaaag ctagacgatg atgatatatc tgtggtttct gccgctgtca 176881 gtgttatttg cgagctatca aaaaaaaacc cccaaccatt catccagctt tcacctttat 176941 tatacgagat attagttacc attgacaata actggataat cattagatta ttgaagttat 177001 tcaccaactt atcacaagtg gaaccgaaat tgagagccaa gttattgccg aaaattttag 177061 aactgatgga gagtactgtt gcaacttctg tgatctatga atctgtcaac tgtattgtca 177121 aggggaatat gctagaagaa gatgattttg aaacagcaat ggcatgcctg gaaagattgc 177181 acacattttg tgattctcag gatccaaatt tgagatatat tagctgcata ttgttttaca 177241 agatcggcaa aatcaatact gattttattt ctcggttcga ccaactgatt atacgcttac 177301 tctccgatgt cgacgtttct ataagatcaa aagcaattga attggttgaa ggtattgttg 177361 atgaggataa cttaaaggca attgtccaaa cattgatgaa gcaatttgta gatgaagatg 177421 tggttatcct acaaactgga agcatcgtat acgaaaaatc aaagagaatt cccataataa 177481 ttccagaaaa ttacaagata aaaatggtga acgtcattat atcgatttgt tcagctgaca 177541 actattccag tgttaacgac tttgaatggt acaatgcagt aataatggac ttggcgatgc 177601 tctgtcaaga catatctgat aaaagccttg gatcaaaaat tggtgaacag tttaggaatt 177661 tgatgataaa agttccttca atgagagaag taaccattgc taatattata aagcttattt 177721 caaatgacaa tattaacaaa cagttgccta ccgtattgag agaatgcatt tggtgtctcg 177781 gagaattttc taccctagtt gaaaatggta acgacttaat aaaaatcatg actgagaata 177841 tcagttatta ttctcatagt gtacaagaag ttttaatttt agcacttgtt aaagtattta 177901 gtaattggtg taataacttt caggaggata aacgctttga aattaaaatg gtgttaaaag 177961 agctaattga attttttgaa aatttatctt attcgagtac attcgaagtc caggaaagaa 178021 gcgtagaagt tttagaattt ttaagactaa gtttggaggc tttagaggag gatacggaag 178081 gtctaccaat gctactgagc gaagtcctgc ctagtttttt taacgcctat gaactcgcac 178141 caattgcgcg tgggactcaa ttgaagttag cagtagatga gaatcttgat ctagaaactc 178201 catttttgac aaaggaggca gctgatgaac tcttagatga acaaaaaagt gacgccatca 178261 gtgatttaat gtctgatatc tcaatggacg agcaagttga actaaaattc gttgatgatt 178321 ctgatacttc gtatgaagaa aaggaaaaat tggatgattt tgaaaatcca tttgagattg 178381 agagagaaaa ggaacggatg tcaaatcctt attatctagg tgaagaagac gaagaaagaa 178441 ctaagaactc taaagatttg ttggacttga atgaggagga aagtagtgat aaaaagccag 178501 aaactattag attaaataga accgataatt cgttgaattc tctaagttta tctacaactg 178561 aaatcagcag aaagaagaag aagggaaaga agaaaaatag ggttcaagtc ttatccgatg 178621 aacctgttat cgaagccgct cccaaaagga aagatgcatt ccagaaaccc catgataatc 178681 attcaactca aaatcctttg aaaaaggaca agattaatct gagaatgcac tctcaacttg 178741 aaaattttga tttttccaat tttgggcaat cgagtaacgc aggaagagga tcgcaggaag 178801 agggcaacct tagaaaggaa gacgagttag aattaagtcg tttagaggcc aatcttattg 178861 taaaagatga aaaggataat ttaagtgata ctgaagaagt tatagttata aaaaagaaga 178921 agaaagggaa aaagtcaaag tcaaaaaaca aactaaaaac gaaagcaaaa aattctccag 178981 aaccaaatga atttcttcga gaccaaagca ctgacattta acgataaaaa aatcgaagtc 179041 gtgaattctc aatgacagcg attacgtacg taaactataa ttaatttaag tattttattc 179101 tgcatagtat attattgcgg tgcactcaat ttgccgaaag agacggcata tttaataatg 179161 acgcgaatga atcaaaggcc gccaaaggta atcatagacc agagatgatt tgcaaaatta 179221 tttgacatac tattgctagt gtaacaataa cacagcataa ctttgcttag acatatatgt 179281 catttaaggc aactatcacc gagtcgggga agcagaatat ctggtttcgt gcgatatatg 179341 tgttatctac aattcaggat gatatcaaga ttacagtgac aacaaatgag ttaattgctt 179401 ggtcaatgaa cgagacagat actactcttt gtcaggttag gtttcagaaa agcttttttg 179461 aggagtatga gtttaaacca catgagattg tatttggaga aaatggggtt caagttatag 179521 aagatacgta cggcaatagt cataagttat actccttccg tgttaatgga agacacctaa 179581 caactatatc aagaaagccg gatggtgatg gcatcaaatc attcacaatt gcggtaaaca 179641 acacttctac ctgtcctgaa tcacttgcaa atagattgat tgtggtgatt gaaatggatt 179701 cgttaatagt caaagaatac tgtccccaat tccagccaat aaaatacgat cccataataa 179761 tcaaccttaa gtacaaaagg aggtttttgg atgtttttgg aactgctgcc tccgatcgga 179821 atccacagga gcccttggac cctaagctat tggacgtttt tacaaataca gagcgtgagc 179881 taacatcagc cttatttaac gaagaagtgg aatcagacat acgtaaaagg aatcagttaa 179941 cggctgctga tgagattaat tacatttgtt gtaattcaac tttattgaag aattttttag 180001 acaactgcaa tgttaatgta accgatgaag taaaattgga aattaacgta cataggctaa 180061 gcataactgc attcaccaag gccgtctacg gcaaaaataa cgacctttta agaaatgcgt 180121 taagcatgag taacactatc agtacgctcg atcttgagca ttattgctta tttacaacaa 180181 tcgaagatga aaaacaagat aagcgatcac atagtaagcg tagagagcat atgaaaagta 180241 taatattcaa attgaaggac ttcaaaaact tcataacgat aggtccatcc tggaagacta 180301 cccaggacgg aaatgataat ataagtttat ggttttgcca cccaggggac cctattctta 180361 tgcaaatgca aaaaccgggc gtaaaattag aattggttga agttactgac agtaacatta 180421 acgatgatat tttagaagga aaattcataa aaacagcaat ctctggctcc aaagaagagg 180481 ccggactgaa agacaacaaa gaaagctgcg aaagtccatt aaaaagcaaa actgctttaa 180541 agagagaaaa cctgccacac tctgtggctg gaactcgaaa cagtcctttg aaagtgtcgt 180601 atctgacccc tgataatgga agcacagttg ctaagaccta tagaaataac acggcaagaa 180661 aattattcgt ggaagaacaa agccaaagta cgaattacga acaagataag cggttccggc 180721 aggctagttc agttcatatg aacatgaatc gggaacaaag ttttgacatt ggtacgactc 180781 atgaagtggc ctgtccacgt aatgagagca attctttaaa aagatccata gcagatattt 180841 gtaatgaaac tgaagacccc acccaacaat ctacatttgc aaaaagggca gacaccactg 180901 tgacatgggg aaaagcgtta ccagctgcag atgatgaggt ttcatgcagc aatatcgata 180961 gaaaaggaat gctcaagaaa gaaaaattga agcatatgca aggtctgttg aattcccaga 181021 atgacacaag taatcacaag aaacaggaca ataaagagat ggaagatggg ctgggtctaa 181081 cacaagtaga aaagccaagg ggtatatttg actaaaacca taatgcaaaa tcagtataaa 181141 ggcgtgtaaa tattagatga agtagcaatt atcatgataa tatcgatcgc tgtttttttt 181201 tttttttctg tctcaatttg gtgagcgtgc ggctgatggt ccatcacggt cggggaacaa 181261 actaaaattt tcaatagcat aatatctcta tattgcatag ctttttactt aataggaact 181321 taaaaatttc attgatgcta ttatatttaa ctcataagtc aatctctttt tccattttga 181381 ttagcttatt gcgacatgga ctatgaatta taataacttt gaaaattcga agggtgatgg 181441 acattctagg cttcccaaac ctacatactc cggaacgcta tcagatggct atgatgaatc 181501 gaaaattaaa aggcaaaaaa cagactctgc ttttaatgca gcttactcac ctcatatgta 181561 tccgaactct ccgtattatg aaggttcatg gaataccggt tatactcctc aacttcatca 181621 tgtagcccct cataatcaat atttccatcc aatacaaccg tccactcagt acaattatac 181681 gagtcctccc aattatacag aaaattacat accgccagtt catcagaata tatcttatgc 181741 accagcgctt aatttacaga agtggccatc atcatattgt gaaaacactc aagccttaaa 181801 gaatgataaa gattaccaaa catcaattag ttatgaagat gttgcaatac cgaccgtaaa 181861 ggaaatacaa ttgattgaga aaaacagagg gaaagatacg tttatgaatg aaataagtcc 181921 agtaccatca agcaaggatc aagcatctgc ggagcctaca gaaatcccaa gaaaggatcc 181981 cgagctggca aattctaatg ccgaagatga tcataataac ttagggctag aagatgatga 182041 tcgtgatgag cagttagaat cagaggggtt gggtaaggtg gttttggttc ctggaacctc 182101 catagcattg attactgatg aagatgttaa aaagtggaga gaagaaagaa aaaaaatgtg 182161 gctactgaaa atatccaata acaaacagaa acatatgcaa gaaatgggca taaaggaaga 182221 tgaactgaag agccaaccta gcattttcaa agagtcaagg aaagaaaagc aatttataca 182281 gagtattcaa aatcaagtgc agagaggaaa tccgaagatt gacttgaact tgaaattgat 182341 acagcgagaa ttcgcaaacg aaaactccca acttttggac tttataagag aattgggaga 182401 tgtaggatta cttgaatatg agctatctca acaagaaaaa gatgtacttt ttgggagctc 182461 tgaagataat aataaaaatc attacaaacc aaattacaaa aacaggaaac ctaatctgag 182521 tagagccaac tttactagaa ataagtaata gaatagcaaa tattgatata catggaagag 182581 tacatgcaaa ggtgcgtaaa aaaaaataag tcagataaaa ctaattactg tttagaaatc 182641 atgagtatat gaaactaatt ttgaagagct ttaactgcta ggttacttaa aacagtagtt 182701 acagcagcac caaggaacga accgaaaatg gcaccttggt aaaatgaacc cttattctct 182761 ctctgtactt tactttcaga agcgtctttt ttcttacttt tcgttcgtga ttttgtggaa 182821 gatgttgtcg ttttgtgctt cctgactcta ccaggcgaca cagccttctt aatgtgttgt 182881 tcattattaa ctaatgactt tttattaagc ggtccaccgt ttttggcttt atttataacg 182941 aacccatcag cagagtttga acttgcatct gtcagtttat gcactctaag tttttcttgg 183001 tcgttgtttt tcttcagtgt aatcaatgca gcgttgtctt ctttcattgc tgtcattttt 183061 tggagaagta tttatatatt tattagttat ttaatgtgtt tataaattta tcttgaggct 183121 ggtgaaatct attccaagta ttttaaatat gtttgcaaat gcgagtctac tactttggtt 183181 ccatatgatg tcagttttac aacaatttat actagagata gccaatatac ttgtttcagt 183241 tctgttttgc cgtaatggaa ttatagctcc gacaaatgta atcttatgca ctgaaattca 183301 atccattgtg acaagaatta tgtattttag ttcttatttg atttatttcg acgcctcgcg 183361 cgcgctctta gaatccggcc cgacaaagga tctgaaacaa gtataaatca aatggccaat 183421 ataatgtcaa gcctgtttta tgtggcaatg tttagacaga aaatcacgcc tgtaggggtc 183481 cacatatctc cagaataatt agagagtcgg tgtccttatg agatcttcct taaagcgaac 183541 agattgatta atcatgtttt acgcgaggat atacgataaa aacaagtgaa cagctcttac 183601 ataacaacgc actcactttt ctctttttca gaagcttttg cattgagaag gctgcttctt 183661 cgcttaaact tgtctttttt gactggtgcg tgtatttctg agtttttttt gtgagaatgg 183721 attttccttt ttgcttcaaa tttcgtaaca cgttcttgtt cttgttcctg taactgtttg 183781 gctagttctt tatcgttttc aatttgctga atttcttcaa gtagcaaatt tccagttcca 183841 aaatcacgtt caatgtcagt tgacaattgc tgtccattta cctctgctgc actaaagtta 183901 ccggcaaaaa aagcatcgca ggagccgtcc accgaatcta gggattgcca tacaatatct 183961 ttacaatttt tataaccaaa gtccgtaacc aatgtgtata atcgatcttc gtatttgaac 184021 aatgtagaaa aatggtcatt tctgaataaa atggagaatt tgttgtgtag cagcttttct 184081 ctcaatcgta ggagtccaaa ggcggtcaac tgagtcggtg attcgttcaa aaacagaccc 184141 aaatgcatgg catcacgtaa aacttcgtcc gagttttcat cttgggaaat tccacaattt 184201 atatcagctg cttgtgttaa gattctctgc gcagattcat aagaataatg agatagtttc 184261 tcatcaatgt tttcatttat gaaactgttg ataacccagc catggacaac atcaacgtta 184321 aacaatcgaa atattgacat ctctttagta ttttcaaaag acccattaaa ctcagggtta 184381 atatttaaac cttcatgtaa tctaggtaac aaacttagta actcacttat atcagtacta 184441 ggtttatctg taacttgtaa agcgatatct gctaagactt caataagttc ttttaaagat 184501 atttgacttc ccttatttac caaccttatt aactcattgg aaaaacgtgt atgatctggt 184561 gaaagtatta gaatatttgc aagtgctaac aaggcacaag gtccgttttc gttttgcagt 184621 aatattcgat ggttttgacc attaattttg acacttttag tcgtgaaact taaatccatg 184681 aaaagatatt gcaataaaca agaattgcag tgatgtgaat ctactttgag ctgttcttta 184741 aagcgccttg tagaatgggc attttgtcca acgttttcaa gacccttttt tcgtactgct 184801 cgctgttaat actgcgaaac taaaataaac gacaggcaga tgactaaaac aaatcaaaca 184861 agaacctcta gggaaaggtg tcctaagcgc ggaacttctt ttcgttatgg ggtaaataga 184921 gcggtactta ataatctgtt tacaaagcaa ttttacaaag ttttgatata agaacattta 184981 actaaagaga agaaaaagaa atgaaaagcc attctcttgg cagaggaaac aaatgaagag 185041 gtgcgtgtaa gtgaaataaa tagaccaaat agcatttgat aaggaagaaa taaaagaaat 185101 ttataacagg gtaaagagtt tttcgttctg aaagagatgc agcaatagta agaattaagt 185161 cctagtccaa tttgggaagg gaaaacgatt aaagcataaa ccgctatgtc gaatttatgc 185221 aaaccatatc aatctacttt ccttaaaaat ttttcgtcca attaaaagaa ttcaagtata 185281 atgtacaaga aatggaaaag attgaaaaaa gggagtctat ttttgtagtt ttgctaaact 185341 atctaataga ctttgaacat tattgccagc aggttgctgt tgctgttgct gttgctgttg 185401 ttgttgttgt tgttgttgtt gaggtggcgg aggttggtgt gacattggtg gggcagaggg 185461 ttttgcagat atattttgac cattgtaatt ggtactcata ggagggggag aggatgagtt 185521 catagaggaa tatccaccca actgttgttg ctgttgttga ggagcctggc cttgcattga 185581 ttgtattaaa ccaaccaatt gctgctgagc atgaggttgt tgttgctgtt gttgggccat 185641 tgaaagcaaa ttcgatacaa cgttaggtgg aaggttttga atggcagata atagttgttg 185701 ctggtccatt ggagtttgag aaggtggttg aggaggcgga ccagcctgat aacgaccata 185761 cccttgagga atttgttgtt gtggaggtgg tggtggaata gaagtctggt agcgaccgta 185821 gctctgattc attggaattg gaggttgaga accatatcct tggtcatggg atggtggtgg 185881 catcccataa ttaccatatg gctgttgctg ttgttgttgt ggaggaggca tactgtaacc 185941 ctggtaatag tttgtttgag gaggaggtcc gacagctggg ccgtttggaa caggaagagg 186001 aggagcgcca tatatgtttt gctgatggct catagcacgg taatcagtag gacgagaatt 186061 atttctgttg tttttgatgt tattaaaaat ggcaactgcg tcatcagcgg atatgctaat 186121 atattcatca aatttcgttt caccttgtga gcctttgtag aaagtttgaa catctacatt 186181 gtgtgtttta ttaactaaaa caacgcccca caccccatta tatgcggcat cattgataag 186241 ctttcccagt tccattcttg gtttcaagaa aatcatatca gtttccaaac cagtcccgtc 186301 cctaaacctg ttgaaaacct caatggcata cgtacgatct gcggttcttt taacgaaaat 186361 gttgcaagaa acggtgtgtc ttctggattt cttgtagcca gcaccattgt cgtcattgta 186421 catgtcacca gattcagttt gaaatggtcg ttttgcggaa gaaataaaag tagaactact 186481 gtttgtaccg tgatcaccat gatcaaattg aggacgagca ttcgagctag aaacttccag 186541 gatcaacttt ttgccaaagt tcatttcttg agactcgcat tcaattgcat ctctaacgct 186601 ttgagggttg tcaaactgaa tgaatccaaa ggcatttttg atattgattt gcatgatatg 186661 accgtatgga gagaaaatcc taaataaatc ctccttagaa acgttcttta gcggcaaatt 186721 accaatgaat aatcttgact tcggaggaat attgtgcatc tcggtgattt tattttcacc 186781 gtgcaaatag gctgcataac ggtcgtgttc ttcttcggta atcggcttag ataaatccgc 186841 cctaggaaat ctcatacgtc tttgggcatc tgacaatgga ggttttcttt gatcattgct 186901 tcttgcgccg cttgtggctg aggcgctagc tgttgttgag atagtactat catgaggagg 186961 tacggaaaga gctgtgtcag aatttgaatt taacattgct aaaatcgcag acatcttttc 187021 ttcttgaggt aaatgttgaa actgaggcaa atttagcatg ttactgtcca taatgtactt 187081 gacttgcttt tgtaaaagat cgtaattaac attttccata ttagttggaa agtgagtatt 187141 atcattttct tcacgagtta ttttttttat agcttcatct acgtcctttt gttctttttc 187201 caatgtttca cggcgaagtt cgacctcttt atctttggtt ttatcctttt tgtcttcctc 187261 atcctcaccg tcttcagcgg cactatctga gcctaccgaa ctgttgtcgt tgccttcttc 187321 ttcttcttct tcttcttctt cttcatcatc atcgtcgtca tcatcatcat cgtcatcatc 187381 ctcttcttcc tcttcttcct cttcattatc atcatcgtca tcatcatttc cgcctttttg 187441 ttgatgttct tcttcttctt cttcttctgt gtttattact tccccgtttt cctctccttt 187501 ttcctcctta tcttcctcct cttcatcgtt cacatcttcc agttcgtgtt gttcttcatt 187561 ttcctcctcc ctttcggctt ctctttcttc ctctggggcg tcaaattcga ttccatcgtc 187621 tgcgcttgag ttattcatca attcattctc gttagagtta ctatcgacgg atagttcagg 187681 tgaaggaata tcttgaacat cactgttatg gttttcatct gacatggctt gcagatggtt 187741 attatattat gaaaggacag tccgggaaaa acgtaagtca attattatat tttgaccaaa 187801 gaaaatcgct tgttgctgtg cagaatctaa taaagatgct caagatagct tttattagac 187861 cttcatttag aagtggcaaa atcaaatgaa ttgttttttg tcctttgctt cttccgcttc 187921 attttctctt caacaattca gggttacact caatcacgtg ggataccata atttatcgtt 187981 ctacaaaaaa atgcaagcac gaactagggc ggtagttagg aagcgaataa gaatagcgct 188041 ttttcgtttc aatttggaat attaaagagt gatattatta atggttttct tttttggaat 188101 gtgatctata tacatattta aatagtctct tttgtatttg tggtgtcata atgaaactgc 188161 atcacaccag atgcttaccc atacagaaag tcgattgatt atgaaacttg aagtagcgaa 188221 gattacggca ctcgaaaata aataaaaaga ggaaataaaa gagatagaat acaacttatc 188281 aaaagttcca gatagcccgt acctgtttaa atctttttac ttaaagcatc cttcctcttt 188341 aactcctgct catgagcaag ctgaagcttg tgttgctgta cagctggtga atcagaatcc 188401 actgaatgtg ctggacatgg cagcacagaa ccgatggcca ctgatgcgaa tgcaatgaga 188461 aatgtagaaa agtataggtt attgactatt ttgtttctag tgactgctct catgatatgt 188521 gtctgaatta aactaattgg ccttccgtgc ctgtaaattc aataaataaa taggatgtta 188581 aattttccta atgtgtctcg aggtgcttat gttatcgtgc aagcgctgag ttcgaaacgc 188641 tgttttgatg aatatcctat atatatcaaa agtacaaaca cggggaaaga gagccatccc 188701 atcaaaaaaa ataaaaaaag aaaacccttg cagaaggaga actggtgtag aggtttccgg 188761 tcttaatgga cttaagcacg tgacttttaa aacccatgca tcggttacta tggttaccat 188821 tacttacgat tttttttttt tcgttatgaa ccctgtgccc gaggggtttt caggcacata 188881 gatcaaagtt ctactcgttt acctgtaatc ttggcgcgtt taggtctctt tttttttctt 188941 ttttttttct tcttttttca tttgtactgc gttatagttg tttatggaag gtaccaatgg 189001 tgaatatgga aaaaatgaag tcaaatagaa gaagaaagag aagctagctt tgaggtaggt 189061 actgttttga gggtttttgg gtgcttcaaa tttgtcttct caactacctt attatagggc 189121 tcaaaaataa ttgacgtcat cgctacaagt cagatgtcga tgttaagaat ctggagttgc 189181 atcgtacatt tcttttccgt gcaggcactt gattcacgaa taaagccaga cattgaattc 189241 aaaaggcgac aaaggatatt tatcaattca tctaaagaag agaatggttc atcttctagt 189301 gccgttactg ttacccgtaa ccctgtgctc agctctaata gcccatctcc tccgctatgg 189361 aatacatggg aatttagact atattatttg gcgttcaccg tagtagttcc tttcatgata 189421 aaggcggcat tggctacgag ctccgagtct aatccaaact actataaatt cagcggactg 189481 ctagcccatg gttggattct gggccgcaaa gtggataaca gcgatcctca gtataggttt 189541 tttagatcca attttttttt gttggccatc ttaatattac tacaaattat attaaaaaag 189601 gtttttgtta aatttagtaa aattccgaaa acaaaattcg attttgcgtg tggattagtt 189661 tttgtctgtt tcatgtacgg gatcaattct gttaagctct ttacgcatgc ttttattttc 189721 ttcactttgg cacattcgct aaagagaaag cgtttgatag ccgcttttgc gatttggtcc 189781 tatggtatct ttacactatt catcaatcaa aaaatgaaaa atctcccctt taataatatt 189841 gctatcatcc taagtcccat ggatcaatgg tataagggta tcgttcctcg atgggatttt 189901 tttttcaatt ttacattatt gcgtttgtta agttactcca tggatttttt ggaaagatgg 189961 catgaacaat tgagccgcca accttcgata gattacgatg atagacgacc tgaattcaga 190021 aaaagtttat ctggttctac tctacaaacc atttatgagt caggtaagaa tgttctggag 190081 gaaaaggaac gactggtagc agaacatcac atccaggatt acaactttat caattttatc 190141 gcttatatta cttacgcgcc attgttttta gtgggcccaa ttatcacttt taatgactac 190201 ctttatcaat cagaaaataa gcttccttcg ctaacgaaaa aaaacatagg cttctatgcc 190261 ctcaaagtat tttcgagttt gcttttgatg gaaattatcc tacattatat ctatgtgggt 190321 gcaatagcaa ggaccaaggc atggaacaat gatacaccct tgcaacaggc tatgatcgcg 190381 ctgttcaact tgaacattat gtatttaaaa cttttgatcc catggaggct ctttcggctg 190441 tgggccatgg tcgatggtat tgatgcacct gaaaatatgc tacgatgtgt ggataataat 190501 tatagtacag tgggattctg gagagcctgg catacaagtt ttaacaagtg ggtaatccgt 190561 tacatctatg ttccatttgg cgggtccaat aacaaaatat taacgagctt tgccgtattc 190621 tcatttgtag caatatggca tgacatccaa ttacgagtgt tgttttgggg gtggttaaca 190681 gtccttttat tattaggcga aacctacatt actaactgtt ttagtagata tagattcaga 190741 agctggtaca ggtttgtttg cggtatcggt gctgcaataa atatttgcat gatgatgatt 190801 attaatgtct atggattttg cttgggtgca gagggaacga agcttctatt gaagggcata 190861 tttaacaatt cacatagtcc ggagtttttg actgcggtaa tggtaagcct atttattgct 190921 gttcaggtaa tgtttgagat tagagaagaa gaaaaaagac atggcatcaa cttgaaatgt 190981 tgatctagtt attagataag ctatgaaagt caatcctttt aatcgagaat gtaaatatgt 191041 ggaatacaca attttaacca aagtactata tatgcgttac aagtaattta aatttaagtt 191101 caccgaagta aaactaactg caagattgtt acaaagaaca atgcactatt taaatcacac 191161 aatggctatt gaaaactgta actgtcagaa atgctgcatg tatctatatg catcactaag 191221 ttgcgacttt taagaaactt ccacagttct caactcttct ttgtgctttt cacacatttt 191281 cacaattttc cgaaatctcc aaattgaaaa aaaaataaaa ataaaaaaag gcaggagaag 191341 actaagtatt cattattcgc tgtttcataa ataaaaggat aaaaaggtta aggatactga 191401 ttaaaatgtt tgtcagggtt aaattgaata aaccagtaaa atggtatagg ttctatagta 191461 cgttggattc acattcccta aagttacaga gcggctcgaa gtttgtaaaa ataaagccag 191521 taaataactt gaggagtagt tcatcagcag atttcgtgtc cccaccaaat tccaaattac 191581 aatctttaat ctggcagaac cctttacaaa atgtttatat aactaaaaaa ccatggactc 191641 catccacaag agaagcgatg gttgaattca taactcattt acatgagtca taccccgagg 191701 tgaacgtcat tgttcaaccc gatgtggcag aagaaatttc ccaggatttc aaatctcctt 191761 tggagaatga tcccaaccga cctcatatac tttatactgg tcctgaacaa gatatcgtaa 191821 acagaacaga cttattggtg acattgggag gtgatgggac tattttacac ggcgtatcaa 191881 tgttcggaaa tacgcaagtt cctccggttt tagcatttgc tctgggcact ctgggctttc 191941 tatcaccgtt tgattttaag gagcataaaa aggtctttca ggaagtaatc agctctagag 192001 ccaaatgttt gcatagaaca cggctagaat gtcatttgaa aaaaaaggat agcaactcat 192061 ctattgtgac ccatgctatg aatgacatat tcttacatag gggtaattcc cctcatctca 192121 ctaacctgga cattttcatt gatggggaat ttttgacaag aacgacagca gatggtgttg 192181 cattggccac tccaacgggt tccacagcat attcattatc agcaggtgga tctattgttt 192241 ccccattagt ccctgctatt ttaatgacac caatttgtcc tcgctctttg tcattccgac 192301 cactgatttt gcctcattca tcccacatta ggataaagat aggttccaaa ttgaaccaaa 192361 aaccagtcaa cagtgtggta aaactttctg ttgatggtat tcctcaacag gatttagatg 192421 ttggtgatga aatttatgtt ataaatgagg tcggcactat atacatagat ggtactcagc 192481 ttccgacgac aagaaaaact gaaaatgact ttaataattc aaaaaagcct aaaaggtcag 192541 ggatttattg tgtcgccaag accgagaatg actggattag aggaatcaat gaacttttag 192601 gattcaattc tagctttagg ctgaccaaga gacagactga taatgattaa acgctctgaa 192661 tgcaaagatt caatgagatt ctctaagaat tctattgata agatttaaag gtatttgaca 192721 agtagagatc tttatttttt cttgcatttt gtctagagaa atctcaactg acatactcga 192781 catgaaattt ttggtattgt gtcttttatt ctattgcttt aagaaaactg tgacatatag 192841 ggaagacatg cttaacaaga agatataatt atataatata tatattatta ataataacat 192901 ccttactgca gtcctgttgt gggagaaaat ggagagagac tatgtttcgt atcaattcct 192961 aaaatcaaaa aaaaaaaaaa aaaaaagtta aacaagcact cgctgttcat ttgttttaca 193021 agtattcata ctctaatagg tcattgagct tcttttcttg aggagagatc caatttgaag 193081 tcggaataag atttgctttc attagcgtag gcaataatta tgagataaat ggtgcagcac 193141 tattaagtag tgtggatttc aataatttcc gaattaggaa taaatgcgct aaatagacat 193201 cccgttctct ttggtaatct gcataattct gatgcaatat ccaacaacta tttgtgcaat 193261 tatttaacaa aatccaatta actttcctaa ttagtccttc aatagaacat ctgtattcct 193321 tttttttatg aacaccttcc taattaggcc atcaacgaca gtaaattttg ccgaatttaa 193381 tagcttctac tgaaaaacag tggaccatgt gaaaagatgc atctcattta tcaaacacat 193441 aatattcaag tgagccttac ttcaattgta ttgaagtgca agaaaaccaa aaagcaacaa 193501 caggttttgg ataagtacat atataagagg gccttttgtt cccatcaaaa atgttactgt 193561 tcttacgatt catttacgat tcaagaatag ttcaaacaag aagattacaa actatcaatt 193621 tcatacacaa tataaacgat taaaagaatg agatttcctt caatttttac tgcagtttta 193681 ttcgcagcat cctccgcatt agctgctcca gtcaacacta caacagaaga tgaaacggca 193741 caaattccgg ctgaagctgt catcggttac ttagatttag aaggggattt cgatgttgct 193801 gttttgccat tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc 193861 agcattgctg ctaaagaaga aggggtatct ttggataaaa gagaggctga agcttggcat 193921 tggttgcaac taaaacctgg ccaaccaatg tacaagagag aagccgaagc tgaagcttgg 193981 cattggctgc aactaaagcc tggccaacca atgtacaaaa gagaagccga cgctgaagct 194041 tggcattggc tgcaactaaa gcctggccaa ccaatgtaca aaagagaagc cgacgctgaa 194101 gcttggcatt ggttgcagtt aaaacccggc caaccaatgt actaagcccg actgataaca 194161 acagtgtaga tgtaacaaag tcgactttgt tcccactgta cttttagctc gtacaaaata 194221 caatatactt ttcatttctc cgtaaacaac atgttttccc atgtaatatc cttttctatt 194281 tttcgttccg ttaccaactt tacacatact ttatatagct attcacttct atacactaaa 194341 aaactaagac aattttaatt ttgctgcctg ccatatttca atttgttata aattcctata 194401 atttatccta ttagtagcta aaaaaagatg aatgtgaatc gaatcctaag agaattcaac 194461 agcgtaaaat acaaagagga taacgacaac gaaaaaaaat acactccctg attatgatgc 194521 ctctgagctt gacattttcg ttgtcaacca agaaaaccat gagccaaaaa agcgtcctaa 194581 cgctcccagt agctttttca aaacactttc ataatcttca gtattggcat cgccttcttt 194641 tacaattgac ttagcgtttt gatcggcggg tttatctatt ttctgtattt cttcttgttc 194701 ggacatatcc gtattttcag tatcagaacc gttgatctca tgttctgatt cttgcgtgtc 194761 ggtgacgtct gtatcttcat taactcttgt gttatcatta tcattacctt cagatagatt 194821 gtctaaacct ttgtcctgtt tattctctgt ctgttcctga gaaaagtttg gagagagctc 194881 cttattctct tcttttggat ctctttctac tggaacttcg ttcaatggag catgttcata 194941 ctttctttct ttcctggtag tctcttttgc aaaagcagaa ccatcttgcg aaatagctgt 195001 tttaggggaa ggaaacgtta cattaccttt taaagaagga gttggcgtct cagggccctc 195061 atagtacaac tctgacccat tttcatttgt attgtgtgca gttttgtcgc cctcgtcctt 195121 ttcttcacca gcgcttccgc cgtcctcttc gttatttaaa gtagcaacat tgttttcatt 195181 gctgtgctcg tccacctcct ttggatactc atcatcggca aaccagttac cgttctgatc 195241 tataaatttg aaatgtacct tatctttatc attatgtttg gttaccgaag attcatcaaa 195301 tttgtattcc catttcccgc tactggtatt tattttcatg ggtacacctt cccaattggt 195361 aaactcccca gcgatcttca actctggaaa gtcttccgcc ggatgatcaa atacaatggt 195421 gaccattatt tagttgcttt gcctatctta atgttacaac caagtatgta tgtatgtacg 195481 tacgtatgca aagaagtgga tatagagaag gaaagtaggg gagagaggga aagaacaaaa 195541 aaattgaagt tatttgagat agtcttgtat tatttatctg tatgtacacc gtattggtgg 195601 aacatcactg ccaaattttt tatcccattt tcacatagtt ccccttaaaa gaaactttgt 195661 tagtatcttt aaccctttac actgtggggg taaaatatta ccgcttcgga gatttctttg 195721 acaggggagc agggaaaaag cgatgagtga aagaaaggga atgcgatgat aaagatgata 195781 atgttgcaaa cggtgagaaa cttgcagatc gcagtggcta attcttaatc tttatatttt 195841 aacaagactt ctaaacgtaa accgcagatt gctgcataca tacaaggata cacacacaca 195901 gacggacact aaacatctac gtacatacat atacatatat acataatgtt taacgtgatt 195961 ggtgggggac gttaccacat ctatccttgc caaagtttat tttgagatct ttgaaatagg 196021 ggttagactt aatcttgtct aaggctaaaa tagcattact gatgttagta taattgatga 196081 aacaacagtt cttctcaggc aagaaattga tttgttccac ttccccatat tgctgaaaga 196141 tatgtcttaa gttgctttcg gtgaagacac gttcatctct tagggaatcg ccgacaaaat 196201 caatattacc cacataaaca tttcttgagg caccattact gactgccaag gcgagcgcat 196261 ttggtaatgg gccggagtgt ttaccccagc cgactttgca acgttttttc tggactgtga 196321 atccatacaa agaactcatt gcataaaact gcgcagcagc agtaggatca atgaatgtta 196381 caaaacagac gtatcgatcg ttcaatagtt ttatactttg taataaacct ccacgaactg 196441 cattacatat ttcttcaatt ttaacatcct taggcaagct gcccaggtaa acagtcctgt 196501 tacccaagtt attggggccg cccgcagatg tagcaattgc agcagcagca gcagactgtt 196561 gtaacaaagc gttagatata aattcacgat cagaaaactc tatcatatgt tccataccag 196621 gttgtacacc tagaaattga gccgcattat gttgttgagt tttggtaata aatgcacatc 196681 tgtcctttcc ataaaatatt ctcttatttt gatagtatgg atttctaatt ggcagattcg 196741 taaccacttt tatagcattt aaaatagacg caaaatgaat aaaggcgatt cccttttcct 196801 tgataatttt tatacagtca atttcaccat attcttctaa atcaaccctc aattgctcct 196861 cagataaatg tgattcttcg ccttcaatcg tcatacggcc aatgtataca tttcttgtgg 196921 caccgtccgt agagattcta gccgctacaa taggatcaat tcgagttggt ttcccccacc 196981 cgattttgat atccctgtca ccgatgttca agcgctttaa aattgcgtct gaatggaaca 197041 atagtgcagc actttcatct ataaacgaaa cgaatgcaca catcttttca ggtatgattt 197101 tgacgtcttc aacgacacca cttctgacat gatccaataa ctctttaacg cttaggtttg 197161 gtggcacatt acccaaataa acagttctac ttggggccga tgtaaaattc aaaggattat 197221 tggcttgtgc attaactggt aaaggcgcat ttgcgttggt tactgcagtt gcagttgcca 197281 taatagtggg tgacatgcca tcagataaca catttggatt ctcatcatca aaaggagaga 197341 cttcatttga tgacctttca tattcataat aacgattgtt attgtggaca acttcgttat 197401 caatttcgaa attttgttcc tgtgaaaacc gttgctgttg tgaatcattt cgctgctttg 197461 tctggaattg agttggttgc tgttgaatac gctgataatc aaaaattccg tcattctcgt 197521 aaaagaacga atcattaggc tctcgtgtaa agtcggatgg taaaagagta aaattaccat 197581 tcataggata cacagcatcg ccaaagtttt gagggccact cgcataagtt tcttggtaag 197641 ggccggaaga actggactgt tgatacattg caaagtcatc ggaagaagga aaaggaggga 197701 acatgttatt attgttatta ttattactga tattattatt gttattgtta ttgttattgt 197761 tattattatt gttataagaa accaccatgt tttaatgcaa ttgaagtagt atgtgatggt 197821 gaagaaaaaa aaaaatacaa cgatagttct ttgtttttct ttaggaaata tctgaataga 197881 aaaggcttca acgaccagaa ttgaaaaaat aaaatagtat tagcaaagaa aaatatgata 197941 ttttttttca aaaaaaaaaa gagtgtcctt gagaattgaa gttggaaacg gatattaatt 198001 agacaaaaaa aatgatgaag aaagataaag tgaaaaatat gaggctggaa tggacagttg 198061 aaccaattaa ggagcctaat tggtaaagca gaacaggtga gtcagaagac ttaaaaaggg 198121 gcaaatatca aataacggaa gaacgaagaa aatagaagaa tacaatgttc aaaagaaatg 198181 aagcgtatgt gtatctaaag gaaaggtaca gagactatca gttctagaaa ttgtaaattg 198241 gtaaaataaa cagagaaagg aagcttaagg agagaattca gtggggaatg tgactctgtg 198301 aaaataatgt ataagagtgg gcaacggtgt tctcgtagat atagcgctgt gctgaaccaa 198361 gtttagtttt ttttactttc caccaaaggc aaagaaactg attaatttat tgctgtgacg 198421 aagggatgga gtatgattgc ggttgtgact gaatctcttt gtagactttc ggacaaccac 198481 aagatccact ttctggtaaa gttaatttca agatcgtgtt tttttctgtc ttttctttct 198541 cttctcatag ccaaaatcgt accacaagga aaaaaagcac cgggttacca tgatggtgga 198601 atcccactgt aagaacataa gaatgataag tacgcaactg ccacggcagt tggaagaaag 198661 acatagtctg ccctcattcg gcgtgtatta ttggacgtca agttaccttt tccaagtgtt 198721 tccctttttt gtcttttgaa tttgtcaata gggagtgaaa ggtccatagt tcaagggcat 198781 tccaaaagtg aggataaaaa aagcgtagtc ataaacactt caacggtgtt gccgagaatg 198841 acgacggtcc ggtagaaggt ggtgctttta tctatgtatt agttatttac tatctgcgta 198901 acgaaactat gatttttttt ttctctcacc caagccgaaa ttaaaaattc tgtcttcgca 198961 cttattccaa atagaaaggg aatgaatcgt ggaactattg gcattgggat atagcctcga 199021 tctactcgca tataacggct acggttcata gtacaaatct cagaattttt cagcaagcga 199081 aaggatttca aagaatgttt ttacagactc tccgcctaac tatgccaagg atgtttttgc 199141 acatgaaacc gtcccccata acgataacaa gggcctgcac agtgcccagc ctcctatctg 199201 ttgcagctcc gcaaccagct cttgttgcag ctaacagacc tttggttttt aacagaggtt 199261 tcaaggtcag aacatctgtc aaaaagttct gcagtgattg ctacttggta agaagaaagg 199321 gaagagtata catttattgc aagtcgaata aaaaacacaa acagcgtcaa ggctgaaaga 199381 tgtaaatctc ttcgctgttc tccgttcggg tgtttacaaa atattctcat tttctaaaat 199441 ctgtaaataa tacatatcta taatattctt ttatgtatat gttaattttt tgtatcattt 199501 tttccaaatt gataaaccaa cacctccgat cagtaacgtt ttctcagaat cagcatcttc 199561 atcattggaa atgatttcta atgatcctgt atccgccaca gtggtacgct ttttatctac 199621 cagtgaaagc ttgcctgcgg taatttccca agcgcgtatt acttgatcaa ccgatgtggt 199681 aatgacttct ttgccaccat taatcaacat accggacgtt attgtcgaag aagctgctgc 199741 agcgataaag tcacttgttt ttaacgttac tttattcgag tcatctaatt tcaggttgct 199801 taaccctaaa ccattatcat caccccctgt caaaattgtg gcggaagttc ttgtagcatt 199861 agcaacatag tctagggact tgacaccaga ttgatgtacc ggcaactgcg ctacaggtgc 199921 gggaagattt gagatagtag cgtccagttt gtggtcaacc aaatcgccag aaatcggatc 199981 aacggaaaat ggtacgtact cggttatatt ataaaccact aaatgtccat cagttggtga 200041 aatgacaaca aggagctctt ctttcagtgc aataaatacg acgttgaata aacagcacgt 200101 cttataacga ccttgcatga tcaggtcaaa cttattctga ttttccctat agtgccaaat 200161 ctttattgtt gaatctgaat aaacagtaac taataagaag tcacctgact gtgatataaa 200221 tttgacatca aaatccatga tccttagatc agaattattt gtggatacag gtaaagcttg 200281 tcgtatggtc atatatggtc gtttattata cttatcgttc aattcccata agaataactc 200341 ctctctagct gaagatgata tcattagttt gtgatttata aactgacaac gttgtaatcc 200401 agacacatgc tttctttgtg tccaaaaatt ctgcaccttc cctgttctat tgttaaaata 200461 tcccagctta attgtagtat cttcagatgc agtacagaat atatgcccat ccttaaaatt 200521 gtcattcgtg ttggtatttg aaacaggaca gattgaaata tctctgattt cccttccgtg 200581 tacaccattt tctaaagttt caggcacaat ggagttgtaa attttcctta aatgaaatcg 200641 ggatgcctta atatacatta atacgtggcc atcagtaatt tttgcgagat tccacagacg 200701 atgggaacca ccacaaactt cactagctag ttcataacag ttggtttcat tgtagagata 200761 aaacaagctg gacttgaacc cataagtaat gtattcacct tttgaattaa agaaagcgcc 200821 ctccaagaaa cctttcatca tcttattaga atgcaagacc ttataactta gtcggtaggg 200881 accctcttcc aaactgtttt tcgtcaactc aataaataca taatagccat ccctatttgt 200941 tactgagaag accgcagagt tgtctttatc ttctacaaat tcgattgagg ttgtagtgtc 201001 tccgggactt aatctcctaa ttatgaaggg ctcctcgctc tcatcaagta agttgtagat 201061 tactaatgta ctaaaacgtg agccgactaa aatatgattt cggaaggagg tcaaacatga 201121 ggaagaaaaa ttttccggct tattgaaaca gtgcttgctt ttaattttta agttctgaag 201181 gcttatttcc aaacatacaa acttctctcg aggatttggg gattgtaaag tcaataggaa 201241 ggagtcatca tcgtattctg taacgagaca gttatttgtc ttagaaagct catctaaatg 201301 gaattcttcg gtctcaatta tgtcagcgct atctttgcta aatttgataa gaaggatgtc 201361 acttttatta ttggaaaaga cagcgatatt ttgcgtttga atcccatttg taattggata 201421 cgagttgaat ttttcatttg ttagtaacaa cttccattgt ttcgtgacat cactgtattt 201481 aagtatttta cccaatgaag tgatagcaat tacaccgaat gaaaaccatt gaaatccctt 201541 gatactttca ttcttttcga aaatatcgcc acattgcttt gcgatatcat ctagactgaa 201601 cgatgtttct tcatcgccgt gtctcttcag ttgaagaaga tcaatcagct ttaacctacc 201661 atcattcccg gaggttacag ctatcatttc gtcgtctttc acatcaacgc cccatatact 201721 cttgattaaa tgtacttcgt aaacgttaga tatggataat tcggcaacgt tttctcgtga 201781 ttcgataatg ttccatacac ggcatgtgca atcttcagaa acacttatta gttttgaatc 201841 attatcaaaa aacattaaat tccatattct tgccgtatgg ctccagccaa cagacagctg 201901 cttgccagtt tctaaatccc acagtctaat tgatctgtcg tcagagcaac tggcaacata 201961 tcttccgttg ttgcttaaat taacataaaa gatagaacct tcatgaccca gtaagttatg 202021 aatttttgtc tccgagaaca ggtcccaaat gataacaccg cccattacag taccagcgtt 202081 aacatatact ttatccggac cgaaaacttt aattataccg gaatatagaa tagatctttc 202141 tcccccaaga gacttcctaa aaagaacttc acaatttaaa tcacaaatta gcactttatt 202201 ataacatgtt aacaaatata tttgcaagtt gtcaaagctg aatgtagcac cggtaatcca 202261 atctgagtta atcctttcga aatccaccaa tgactctttc tttaaaacgt cttcaagttc 202321 cactattgtt actgatcttg caccataggc caaaattttc ccttcactag aaaggctaag 202381 tccatgaact ttattgtagt gaaatagcct acatttgtta atcaacgtag ccgaatgata 202441 gtcatagaca tggatgaaag gcccataacc agctagaaca taatcattgt aaaatttaac 202501 acatagcgca ggaccataat gagacaagtc cttcatttta atcacttatt cttcttcaat 202561 gagcaacttc aattggcggg aatgagaagc taaataacga tgaggtccgc tagcagaagt 202621 tttttcatgc tcatattttt ccactttttt tttcttacat tttttttttc agcagcgtcg 202681 ttttttgtga gacgccgatg tgtatgctag gcttaaatct atcattcaga ccccagtgta 202741 aaacataagc ggtgaaaagt acgtagggta gtatacaact caccaaagca cgactacgtg 202801 aaaatgaccc tgagagtatc atcaatgtta tcggctgtat aaataataca ccagaacaaa 202861 ttcctcttaa agatgtaggc aagaccagac tcagtttctc tgagcagtac cttcaatttt 202921 caatttttga tagatgttcg tcactaatat ttttttattg agttaagttc acccacttct 202981 ggcacttctt ataaccttga taattaaaaa gacctcggcg gttatttttt attttgagca 203041 gttataaagg gcattaccct catcatcttg cggaaatagg acggagcacg tcgcagacag 203101 gctttaacgt aatcaattag ttttgaaaaa tttctccgct atgggtaaac taggtaaacc 203161 gcacagcaca atcagctgca ttttctattt tcaattttct attggtggct tttcactgca 203221 tgatcaaaaa ataacgtttt gttgattagt tttttctttt ttgttcttgt tggttttcgt 203281 atatgaattt tatgtaactg ggtatttaca ggggtacaaa gttcacaaca gagaccatca 203341 atagtttgtt tccttcgaag tttactttgc gtaaccttac taaaagatag cataaacata 203401 taggagtata gagaagagta atggaatcga cagcaatagt gcctaaaggc cctgttgtgg 203461 gtagtgaaga tatggagaaa gcggaagtca ttgctagtgg gtccacagac attatatcaa 203521 caacatcaac agcgacaaca acggcggcga ttggaagtgt acaggaagaa agtgtaaaac 203581 aagaagatgt tcctatggaa ggtggagagg gggaagtcga ggaagaggaa ggcgaaactc 203641 gctgtatctg tggagagctc gatactccag atgactccgg atttttcatt caatgtgagc 203701 agtgcagttc ctggcagcac ggttattgtg tgagtattac tcaagacaac gcacctgata 203761 aatattggtg cgagcaatgc agaccggagt tacatcagct ctttaccaca gatactggcg 203821 aagcaaggtc aatctataaa cctgtgcaag agaaaaggag gcaatcaaga aggaaggcac 203881 gaagtgcagc tgcaagtaaa tctcatgccg ccaatgaagc agagaaaagt cccagaaata 203941 ccagcaatac cgatgataac gtcgacgata tcggcgacga agaagatgaa gtagaagatg 204001 aagcttcggc tgtagcatta gccaaggacg gcaacacgag gtcaagtaga aggaggagga 204061 ggaattcaat ggatgatgct tctaccgatc agtattcact ggatcctgga gatagtgata 204121 agaagctact ggatagaaaa agggcaactt tcatggcaag agaagaaaag caatatcaaa 204181 gaatgcttga aaaagccttg aaagaaagca ggaggacatc acatcaagaa gatcctgaaa 204241 gttatgaaaa tgatgctgat atataccaag gtgataccga caatcacaac ggcaccactc 204301 gattacaaac ggatgttatg ctaacggaag gcaaaccgga ctcggtaaca aatgatgata 204361 tgaaagaaag cctacgacca tcgaaagagc aatcaatgga aaaaacaaat gatgtggaaa 204421 aagaagctag tcaagaaaag gaatcttcta cgggttcggc gcaagacact gagaaaactg 204481 atgaacccat cctaccccta acctcaatat cttcttctga ggatgattca aggaaagcta 204541 gttcgagggg ttctaaaaga gtttccaaac cagcaagaaa gggcaacaga actcgtcgaa 204601 gcaatacaag ttcagacacc aaccaaaata gaaggagtgc tgatataggt accgacaaac 204661 cagtaaagcc cagattaccc cctcaaagga cctcattaaa cgaaatgaga agaagggtat 204721 ccgctatttt ggagttcatt tctagaactc aatgggaatt gagtgaagat cagtctgatc 204781 gagaggaatt tgtacgattc gtggaaaacc agcatttcgt agaaaaagtt gatacgattt 204841 acaacggtta taatgaaagt ctatcaatga tggacgacct gactagagag ttactactat 204901 gggagaaaaa atattcaaat aacactaatg ccattcaata aacgcaaaac actgcaatat 204961 tattctcaac caaagtataa ctgtaatgag gcgaacaaac acatctatac atatatatac 205021 atctatatgg atataaaaac gactaattca acgttgtttt tatcaaccga gcttactctt 205081 gtacgggtaa ccgcaaggat agctagttgc ggatggtata gcgatttggc tggcacgatg 205141 attaaggaat ccaaacatct aatggactag cacattctat cgatttacgg gtcaggtaaa 205201 catagatatt gggatatatc atatatcctt actgagtaac tataattatg gttcatcgag 205261 gaaggacttt gaagtcagac actgatgtaa catctcttaa tgcgtcaaca gtatcacacc 205321 agtcaaagcc atttagacag ttttcgacta ggtcgagagc aaagagtaac gcaagcttca 205381 aaggtttgcg tagagtttta acacatgatg gcaccctgga taatgattat tttaataagc 205441 acaacgtttc tcagaaatgc aagagttctg atgcactttt cagaaagcga acgattagtg 205501 ggttgaatat gacagcttta acaagagtaa agtccaatca aggaaaaaga tcagcatcct 205561 ttcatagtcc ggtgcataat acgctgctca gtccaaagaa cagcagtcat tctaatactg 205621 gaactgctgg tttcggcctg aaaccacgaa gaagtaaaag tacccaatct gttctgagtc 205681 ttcgagatgc gcaagaatct aaaaagagtg aatctactac tgacgaggag gtggaatgtt 205741 tttcggaaga caacattgaa gatggaaagg tgaataatga taaagtaata gccgagcatg 205801 ttatgcctga agaaaaaaag aatgtgcagc aattaaatca gaatgaatta caatccccgg 205861 attcaataga tgaacaagaa gaagataaat caggtactga tggaaaggaa aatcatagag 205921 ctgtatcctt accattacct catttatctt ccaataacta tttcggagaa tcaagccatt 205981 ctatagaaca tcagaaagat ggagaaacat ctccaagctc aattgaaaca aaactgaatg 206041 caacaagtgt aatcaatgaa gaggggcaat caaaggtgac gaaggaagct gatattgatg 206101 acttgtccag ccattctcaa aatttgaggg cctcattggt taaagcgggc gataatatat 206161 cagaagcacc atatgataaa gaaaaaaaaa ttcttgatgt tggtaatacc ttagctgcac 206221 ataaaagtaa tcaaaaacca agtcattcag atgaacagtt tgatcaggaa gatcacattg 206281 atgcccctag gagtaattca tcaagaaaaa gcgactcgag ctttatgtct cttaggagac 206341 aaagttctaa acaacacaaa ttattaaacg aagaagaaga tctaatcaag cctgatgata 206401 tttcttccgc tggtaccaag gatattgaag ggcatagctt actggaaaat tatgcgccta 206461 atatgattct ctcccagtcg actggagttg aacgtagatt tgaaaattca tcatccatcc 206521 aaaattcgct tgggaatgaa attcatgact cgggtgagca tatggcttca ggtgatactt 206581 ttaatgaact ggatgatggc aaattgcgca agagcaagaa aaatggtgga agatctcaac 206641 ttggccaaaa tataccgaac tctcagtcta ctttccccac cattgctaac atcggtagta 206701 aagataataa tgtaccacag cacaactttt cgacctccat atcgagttta accaataatt 206761 tgaggagagc tgctcctgaa agcttccatg gttcaagaat gaataatatt tttcacaaga 206821 aaggtaatca gaatctactt ctgagatcca acgatctcaa caaaaattct gcagccccgg 206881 cctctccatt gtccaacgaa catattacat ctagtacgaa ctccggtagc gatgcaaaca 206941 gacaatccaa ctcaggtgcc aaatttaata gcttcgccca gttccttaaa tcagatggga 207001 ttgatgcaga atcaagaaca caaagaaaat tatggttgca gagggagaat tctattatgg 207061 acttaagttc acaaaatgac ggtagtgact ctatctttat ggcaggaaac attgatgcga 207121 aaagggagtt tgagagaata tcccatgaat actctaatgt aaaaagattt tacaacccat 207181 tagatgaagc attgttgaga gtacaaccta taataacggg aaatgcaaat aatatcagga 207241 aaaaaagcca taacgatgct cagtcaatcg cacattctag cagtgataca gatcataagg 207301 atgaggacga tttgctcttt actaactatg acaaaaaatt tgatgatctt tatccacatc 207361 ttgcaagtgc aaagattcag gcagtgttgt ccggtatatg gaaaagcgaa agttacttat 207421 ttaacaagga tgttaatcca atcaacaaga ataggacaac gagtacaaac cacagcgttg 207481 gccacactgc ttcacagaat gcacgtaact tgctgagggg cccgatgggt tccagcacga 207541 ctttgcacca ccaacgcgtc attaactctc tgcagccgac tacgagggca gtgaatcgca 207601 ggatggaaaa tgtgggctac atgcatacac agccacaaca aaggtgaaaa caaccaacac 207661 gaagcacaca gtttaaaaga gtagctaatg ctttcgaggt aaaacgcgaa gttcgtagag 207721 agcgaatatg tttggacact taaggaacat actatgttta tgcactataa aaggacatgt 207781 acttctatac gagctaacga ggcgtatttg tataacccgg ttaacgtaat aaatgataaa 207841 ttatcgaaca aaaagaaaga aaaacgttga atgcaaccac cgcaaattta gcgatttcgc 207901 tggattccgt atctcttaaa aaatggcatt agtaaatata ccttaaacgt gtctattctt 207961 ttagcaattt tttggtaagt attcctcacg gactataaat actatcggtc agaatcacta 208021 cattcaaatt aatcttgttt taccgagtct ctgacgtttc atttacaagc ttgtccttac 208081 aaaaaaccta ttttattact ttagtccatt ttcctttcaa gttagatatt gttttccctt 208141 cacttatatt ctatttatga gaagaagccc gtccagatca aataataact ttgcagtacc 208201 gaattgctca actaattcaa actctagtca gcaacaatta actacacctt cagatgatct 208261 caacagtaac gaacctaatg acccagatga tagtaggtct ctacctacta tcaagaaatt 208321 caataataaa cattctataa acaattacaa cactttagca tcggccggga aaaacaacaa 208381 caataaacga gctagcaatg ataatttgct cattcctggt gagaatgccc ataaacagaa 208441 aatatacact aaggatgaaa acttgaagag cttgtaccta gatatcgatg tttctgtcgc 208501 taaagcccta tcctcatcag caactgctcc gaagctgatc aataccgcaa gaacttcctc 208561 tactaccact gccactacct caaataatat cctgacatca ccctcttatc gtgaatcaaa 208621 ttattcttct ccatcctcat attctttttc ctcctactac tcatccgcta cgtctgcttc 208681 ctcatcaacc tcatcatttt taaaatcttc agggttatcg tccagagtta agtctccttc 208741 atcttcggtt aaggcaggtt cttttggtgc gccttcgtcc ccaacatctg ggatacctaa 208801 tcctaaaagt agcaagaagc ctatattttt gagacggtat tctcatgata cctcttcaaa 208861 tgaaggtctt gatatcgatg ttgcgatcga aaaattacta caagtgggtg agtcaagaga 208921 aattacaaaa acgtccaaaa aaaagaactt tccattccat tcttgggaaa ttcaactcat 208981 ttgctatcat gcaagagaaa tttttttgaa tcaacctact cttttgagat tacaagcgcc 209041 tatcaaagtt gtcggtgatg ttcatggaca atttaatgat ttattgagaa ttttgaagtt 209101 gtctggtgtg ccatctgata ctaattatct gttcttgggt gattatgtgg accgtggtaa 209161 gaactcattg gaaacaatac tattgttatt atgttacaaa ataaagtaca aagacaactt 209221 ttttatgtta aggggtaatc acgaatctgc taatgtcaca aagatgtacg gtttctatga 209281 tgaatgcaaa aggcgattga gctcgaaagt atggaaaatg ttcgttgacg tatttaatac 209341 tttgccatta gcagcaatta ttcaagataa gatcttttgc gttcatggag gtatatcgcc 209401 cgatttacat gacatgaagc aaatcgaaaa agtcgcaaga ccaacggata ttcctgaaag 209461 cgggctggtt acagacttac tgtggagtga cccagaccct caagtaactg attggtcaga 209521 aaatgatcgt ggtgtttcat acacattttc taagaggaac gttcttgatt tttgtgctaa 209581 gtttaaattc gatttaatac ttaggggaca tatggtcgta gaagatggtt atgaattctt 209641 tgccaggaaa aagtttgtca caatcttttc agcaccaaat tattgtggag aatttcataa 209701 ttggggggca gtaatgagcg ttacaacggg tatgatgtgt agctttgaac tgttaaagcc 209761 gcgtgcattg aaaaataaaa agaagttata caaaaccaaa gtgtagctgt tgctaagatt 209821 ggttttgcct ggaaagcaca ttggttttta ggcctcttat ccttcatttg gaaacttttt 209881 gtcctatgat ttgttttttt cattttattt ttcattttat ttttcatttt attttcattt 209941 agttaacatt attatgcagt tatttttttt tttcccacct tcatggcctc gtttatgtct 210001 tttatcaata tattttttac gtttataagt catttactcg acttttttta cctttgatat 210061 gcaatcatat tattcttccc tccattatgg ctaaataaat gataattata atctatagtt 210121 ttcaagcgtt catattttga cagataagat tatgcaacaa cttggaaggg cggaaggaag 210181 caaaaagaaa actccgatac ggggagtcga accccggtct ccacggtgaa agcgtgatgt 210241 gatagccgtt acactatatc ggacaataat tggacagaaa attttgttaa agtgtcagcc 210301 taatcggcgt aatacgtata tatgtatatt atctgcatat tattacgata atatacaaca 210361 aaacggatta aaacaatcgg tatatttcaa tttgatattt gggataaggt aaaataaaaa 210421 ccgaagatca gtaagctctt gttacttttt tgttggaata gaggatcaag aagcatttat 210481 tgctagtatc caaattatta gtatatcatc atgttttcaa aaaaaaatga tgtaaaaatt 210541 gagaaacagt caccagtcat catgaaaagt gcactgcaag gattaataac gtaataaaac 210601 aagaacgaca gtacataaac gaaagaagag ataactatat tattgtatag aattatcgat 210661 tctcttttag aattctttta ttctccagga aaactacttg tacattctgt ttagctaata 210721 ttgtagcctt taaccacaat aaaatgcact ccaagtataa cccaaaattc attgttttca 210781 aatttatatt aatgagatat tggtaaccta aacatcaaaa atatttttac tcaaattctc 210841 ttttctgaaa acgctgaagg aaatgtgcag gaaaaatgtt tggccatcaa cttttattcc 210901 tagtaccaca actaacgtca cattctatcg aggcaaatgc taattggcaa ctaacactat 210961 cttaacggtt tgataatgtc aacacaaaat tcacctatta ttacaaacga atctaccgga 211021 agttgaaatg cctgacaata atcatacaat tgcatgaata attgcgaaca gatggcagca 211081 aaggatgaac taatcataat tatacattgc cgctgtaggt ttcctcccat aaaaatccaa 211141 atttccaaga aaaagttctt gtgtcttcat acacttaata ttgttatcct tcttcaagac 211201 cggactatat aaagaaaaaa ttttgtaatg ctattatatt tcaacttcaa attattttct 211261 actagtagac ataatggaac ttcgctctca gataatctat ggcgatagat ggacaattga 211321 caatcttctg aaagaattta tataataaga tgtgaccatg acctaaacct gctcacgctc 211381 atgaaaggat acaggtaatt tggcgaaaca ttcccaagct tcgctgatag acctatccca 211441 gaaagtgtct gtttaaaact acaagtattt gcagttttcg ttatccagtt tcgttcaaga 211501 gcattaatgc acaagccact tatattatat aaatttaaac tttgggaaaa tatcatacac 211561 ctattgtacc agtaaatgtt ggaataaaaa tcaactatca tctactaact agtatttacg 211621 ttactagtat attatcatat acggtgttag aagatgacac aaatgatgag aaatagtcat 211681 ctaaattagt ggaagctgaa acgcaaggat tgataatgta ataggatcaa tgaatattaa 211741 catataaaat gatgataata atatttatag aattgtgtag aattgcagat tccctttcat 211801 ggattcctaa atccttgagg agaacttcta gtatatctat atacctaata ttatagcctt 211861 aatcacaatg gaatcccaac aattacatca aaatccacat tgtctacagt aaaagtatac 211921 cactaataga tttgtaattg gtgtatgaag tagtgtatgg tataaacgtt aataagtgct 211981 tatcaaagta ttacccgctt taacagtttt tgtgtttttt tcaagaaaaa tattatatgt 212041 atgaatatag aacatgagtt tatatggaga aagtgtctcg acagctttta aagtcccgaa 212101 aggactaata tcgaataaaa gttgcatcca ttaatatacc aataaataaa gggaaagatg 212161 tccctggaag aatttgacga agttaaatat gatcattcaa ctaaacgcct agatacacca 212221 tcaaggtacc tgctgcgcaa ggctagaaga aaccctaacg ggctacaaga actgcgtgag 212281 tcgatgaagt catccacaat ttatgtagga aatctttcct tttatacatc agaagaacaa 212341 atttacgaat tattcagtaa atgtggcaca ataaaaagaa taattatggg tttggaccgt 212401 tttaagttca cgccatgtgg cttctgtttt attatatata gttgtccaga tgaagcattg 212461 aatgccttaa aatatttgtc cgatacaaag ttagacgaaa agacaattac cattgatcta 212521 gatcctggtt ttgaagatgg aagacagttt ggtcgtggta agagcggtgg tcaagtcagc 212581 gatgaattga ggttcgattt tgatgcatcc agaggtggct tcgccattcc atttgcagag 212641 cgtgtcggcg taccacattc cagatttgat aacagtagct cacaatctaa tacgaataat 212701 tatatccctc ctcctgatgc aatgggtact ttcagaccag gtttcgatga agaaagagaa 212761 gatgataact acgtacctca gtagaatcaa tcaatttata tctgagaaag attctacaca 212821 cagatatata tatatatata tatattattg tatatataca tacctacatt atttttaaag 212881 gcttgcatga tgctgttatg taaaaaaaaa aaaaaaaaat cagtgtaaca taatagacgt 212941 aacacgttca atgacatgat aatactatat atagtaacga taaaatgtaa atggtaatag 213001 atataattat atgaatattt aagtaatgca ttgataagtg atcaattcat atcagggttg 213061 gatagctttt tcaattcttc cagcctatca attagttttt tacggcgtgt aacgggggca 213121 tgagcaaatc tcttggataa ttcataatcc gtggagcagg ttgacgtagc atcgtacata 213181 gtattatttg tggcagataa tgtgttatga tatgctgaga cgttttgaac tcgttccact 213241 ggggtattat tcgcgttgtc attaggaatt gagtttacca gggtatagta atcactaaat 213301 attttgcgtc ttctcacatt tatgaaccaa ttagaaagtt gaatcttggt tagcccagtt 213361 ttgattaaca actccctctt ttcttgttga gttgggtagg ggttattcag gtggttcagc 213421 aaccaagtat tcagtatctg cactgtttcc tttggcaggt tagacctcct gcccgaattt 213481 tgcttcctcc ttgatttaga ttctacaaaa tccgaaaatg gcctgttgta ttgtgccccc 213541 gcatcctttt ccttattgat tatttcatat attggggcgg atttgtagca gggctttgca 213601 tcatcggacg ccgattttga cttctttgaa ctgccatatt gagattgtgt atccatagca 213661 ctgctactcg tcttggacgt ttcaactgta gaagcagtag gagtagcagt agtactagta 213721 ccgccagaat taattgcggg atacgcaatc gaatgatgct gtggaagtaa cacaggcgca 213781 ggatagtttt gttcctcggt actagaccga aggttcccat gcgagtattc tatgttcgaa 213841 aatgccaact cgggcatact ccgtttttct atggagttaa atagaacttg gatagggggt 213901 agactgactt gattgtcaac attcttactg ttcctgtttt gtatttcgca gttataattc 213961 atcttcgaat gtaactattc tcgaaggttg ttagcataaa agtaggggct cggcaagtag 214021 cgatcagtag cactggatag gcgtggtatc gcttgaaaac aagggtggga agatcaacta 214081 aaaaattgta ttagtatata tcttgaccaa tttaacataa tcttaccaat taacagaaac 214141 aggaggcatt aagagacaag aaaacgccgg gcgcgacgaa atcagtcata gaaaattaat 214201 cattaatata tacacgctgt aagaaaacaa aaggacaaaa attaattacc aaaagaaaaa 214261 aacaaactac agcttgatgt acatgaataa attaaggttc aacaaaagag aaaagctgag 214321 agacgtaaga tggcagaaat gacccgttcc cacagaaaga aatctgaatc cgaagaagga 214381 agtaatacgc gcgtgagcgg ataaggtttc ttatctagcc aatcacaaaa atcaacagta 214441 gtaattctcg tgggattctt ttgtgtctct taaaattgcc ctttacgtac agtcttcgtc 214501 cattatcagg acgatttgac agaaaatgag cgagatcaga aatataccgc taccgatcat 214561 gagtgctcag aaaaccccgt ggataaccca acggtccgaa agtgacagtt ttttcttttg 214621 ccgctttact ttttttgcgt cttaaagggc tgtggctcct ctgcgcctgc gccagagtag 214681 cggtagggtt cttacttcgg gcaacgccga ctctgggtgc attcgccagt gtgaggaagc 214741 acgctgcttg tgcttgttgg aagtgtggac taggtcaagc ccgccggaca ctaggaaaca 214801 cgcacaaaat tctcaggcac taaataggcc agaagcaaaa agccgtcggt agtgctcctt 214861 ttctctgttg ccgttaacgg tcaggtctgt taagacacat aacgaaaagc atatgtataa 214921 taggcaccga catttgtgcg gcatattctg tgcttagttt gcagtacaag acgagcttcg 214981 gaggcatact actttaatca tatttgctca cttttaagtt gctcactttc taatacgtgc 215041 attcctttac aagcttacta acacattggc ttggcactta aaacactaat gaaacgtgtt 215101 taaggggccc gacaatattg ctattatgtc gctctcaaca gcttgtttgc gaattttaaa 215161 tttgatagct ccctctttct cctcctctac cgttcgacat gactaaaagg cgttggcacg 215221 attttctttg atgctaatgt aatcaagtca agtatgggtt gctttgacga tccagatgca 215281 gaagtcaaag ttacgagtca aaacctacga gactagacat atctctgcag atgaaaaggc 215341 ctgttctata aaaaaaaaat cactgttaaa gttcagacag aagcttattt caaggaaagc 215401 actgtgattg atttattcac tatcgagttt ctacaggtgt tgaagttcat atatttgcac 215461 gtgctcgtag ctcttttctt cctttttgag acataaaaat atggaatatc ttggcacccg 215521 ttacaagccg tctctaaaaa tatacatggc gtacataata atctccagct gattcaaata 215581 tcccgcgctt ttcccgtggt aaatactgtg tgtcctatta ggctttctct tggcatttca 215641 cttcttaacc tctaaggtat tcaaggggcg gaggtgtaat aaaaacaaga aaaaaaaaaa 215701 aaagaggaaa tttgtggcaa tcttcctaat ataactatgt tgaaatgtgt gtactaacac 215761 cttatactat ctatatcctt tgtctaaaca gctctgccga taaaaaaatt ccccgcggag 215821 atgtccatac tgactaataa aattgtcccg cacaggcaaa aagcaacttt aaatgcatgg 215881 gctcctaatc ttagaattaa acgtatttag tcttcctagg caagaaatct acaagtcata 215941 ggagtatatg ttgtgtatac tatagttgat tgcctgcata aatcgatgtg taattttctt 216001 tcaaccgata actaaaattc gttcgtgttt attccatgaa ggtttttatt ctcaagaaaa 216061 tagcgtgctg tattttgtaa aattgtgccg agtgtgttag cttgaacctg cacagagctc 216121 cagtccttga ttgcaatagt gtccctgatt tcagggaacg tccatgaacg aagtgggtca 216181 cctttgtcga cccagagttt tggcccgaag ataacgttct tgtaaaaggt tctatccatt 216241 aacccttcct ccaaacattg ggtaacgcct attagggaaa gtaggtagtt ccatgaccaa 216301 cgattaatgg caatgatagt gggttctata tatgtaccgg ctccatacat aagctctgtc 216361 cattcgcttt tccatttttc gaactgcagt ttagtgtttt cccacaatgt tgtgcccaaa 216421 aagacttcgt caaagtttac cgtatcagga cattcttttt ggaggtcttt taacgtagtt 216481 gaaaggaaat ctacgtagtt cgatatgctg aatgggatga atggatcgtc aatgagctcg 216541 agtgattttt cgacaagata tagcattatc tcagaaagta cctctccctt ctttttgtct 216601 cttagtttat ctttgatgaa atcgaatttg tcttctactg tgtagatcgg atgttctcta 216661 ttcatgactc ctggagatga aatgatcgca actggaatcc cttgcgctag atacggcgtc 216721 cagtcgccga actggtgaac attatccact ttaacgttaa atttacggct tgtcatgttt 216781 ttttgaaaaa gatctactag tagcggatga cattgtatct ctaaattgtt actatcatcc 216841 catataccga tttggccgac gtcgataatg gtgtatattt cactcttcaa tgcctctgtt 216901 ctcttttcca tcagctccgt ggctcccgct tcattaaatt cagagccccc aaaggaaatg 216961 aaatatatat ttcttagagg cttccagtca aatttgtaaa ccatttcttg atataattgg 217021 atcagagaca gcaaaacgac ggttccaaaa gaaggataca tagtgccata actagcagag 217081 ttcctcggtg cagcaataac aattgccctg cccgcttgtt ccgatccttc aattttacca 217141 actatatcgt gaaccgggtg gcgttcccta attgctgttt gcactagtag gtcaagtcga 217201 caatcgttaa gcgacccact gaataaatta ttagaaaact ttacgccagt gtctgataat 217261 atagctagta ttttatctcc ttgattggca gatatcggta tggatggaat tttgggtagg 217321 cacttggctt ccgtagcatc gataggatct cttattgatc cttcccattc aggcgtaagt 217381 gcatcaccag taccatactg cggcaacgca actgacttca tttgtatcac gtctttgttg 217441 tcttgataag gctcagaaat aaagataatt gctttcgcac catattcttg agcagtcaac 217501 atttgttgga aaacataatc tccgtaatgc actagtaaaa taaagtcacc gtttaaaagc 217561 ccttgatctt gcatagaagc catatcgtcc aacgatgctt tattagcata aatcaccggt 217621 atgttgttca attgaccatt atggctcatt gggttaaagt tctcctcatt taagggaata 217681 tcaaaccctt ctgtatcatc ctttgaatat acacgaagtg agacatttcc tgggtaattc 217741 gaatacgcca tgaactcctc ttccccagct agccttatac catttttgtc gaacgactct 217801 ttaatataat gtctaatagc ggcatcacca cttgttcctg acatgtgggg catactacta 217861 atatactcta aatctctttc tatctttgaa aggtctatcg atttccgagc atactgtaaa 217921 aggagatcat ggtccgagaa tgatccattt gaacctcgag cttttccatt cggtaaccta 217981 tcactcgcaa taatcaacgc tgcaatgata gacatcatca tgatgtaaaa tattctcctc 218041 attaccataa cattacctat tttacttaag aacaaatcga atttctcaga ggccagggaa 218101 atcatttgtg ctagcggatc cactacattt ttctttactg gaatcaccac gttattttca 218161 aaacacatac gaaatcgctg gactttctca ctaaaggctt ccggagcctg cggttcttcc 218221 atccccatct cttccacata taccgggggt tctgatggca ttcctatagc ttgctcaaag 218281 tcctgcgagt ttagctcatc ttgtgagtta tttgctggtt cttcaacatt cggaagagta 218341 gtgtagcccc tagtattcac catatccttt gtatactcat atgcgaactt gtctaataca 218401 atgtatacca aaaataacag cttgaaaaaa atctcagggt cttttcattg aataatctca 218461 ttctgctatt ttaagttttt cgtttgcaac ccgagactgt cgagctagaa aatttcattg 218521 atacgattta aaaataatcg atgccagtaa tagcctcaaa aaacttatgc aaaaatacga 218581 gatactataa actacagctt agctaactct aacattatta tataaaacaa tgggcttcaa 218641 tatagcgtat gtctagctca cagcatgtgt tccaaataca ttaaagaaga tctcttttgt 218701 tgttgatact aaccagtaaa gttgagagtt ataacaatga aaataggatg ctgtgcgact 218761 ttttttatcc acagttaggt ggagtcgaat tccatatata tcatttatcg cagaaactaa 218821 tcgatttggg ccattctgtc gtcattataa ctcacgctta caaagatcga gtcggcgtac 218881 gacatcttac caacggtcta aaggtctatc acgtaccatt ttttgtgatt ttcagagaaa 218941 ccactttccc cactgttttt tcaacatttc caataataag gaatattctt ctcagagagc 219001 agatccaaat tgttcattct catggtagcg cttccacgtt cgctcacgag ggaattcttc 219061 atgctaatac tatgggattg agaactgtgt tcacggacca ttcactctac ggttttaata 219121 acttaacgtc gatttgggtg aataagttgc taacatttac cttgacaaac atagatcggg 219181 ttatatgtgt ttctaataca tgcaaagaaa atatgattgt tagaacagaa ttaagtcctg 219241 atataatctc agtaattccc aacgcagtgg tgagcgaaga tttcaaacca agggatccta 219301 ctggtggcac caagagaaaa caaagtaggg ataagatagt gatcgtggtc atcggaaggc 219361 tctttccaaa caaagggtcc gatttactta ctcgcataat tccgaaagtt tgttcctcac 219421 atgaagatgt cgaatttata gtagcgggcg atggtccaaa gttcatagat tttcaacaaa 219481 tgattgaaag tcatagacta caaaaacgtg tgcaactctt aggctctgtt ccacatgaga 219541 aagtcaggga tgtattatgt caaggtgaca tatatttaca cgctagttta acagaagcat 219601 ttggtacaat tctagttgag gccgcatctt gtaatttgct aattgtaacg acacaagtcg 219661 gaggaattcc cgaagtgtta ccaaatgaga tgactgttta tgcagaacag acatccgttt 219721 ctgaccttgt tcaagcaaca aataaagcta tcaatatcat aagaagtaaa gctttggaca 219781 cttcctcttt tcatgatagc gtgtctaaaa tgtacgactg gatggacgta gccaaaagga 219841 cagtagagat atatactaat atatcttcta cttcttccgc tgatgataaa gattggatga 219901 aaatggtagc aaatctttac aaaagagatg gaatctgggc taaacatctt tatctgttat 219961 gtggaattgt agagtacatg ctttttttcc tcttagagtg gctatacccc agggatgaaa 220021 tcgatctagc tccaaaatgg cccaagaaaa cagtgtctaa cgagacgaag gaagcaagag 220081 aaacttaaac tttacacaaa acaaaggaat gttgtatcca tttatttact gtatttgaat 220141 gttatagacc tgctagaatc actcagtcat ttgtaatatg taacaacatt ttgagatttg 220201 agtcgtatat ttttcctctt gcgctttaaa tacgaaatgt aagaatgatc tctttcatgc 220261 cagagttcat cttctgccaa aggttgatca agctttaaat ctaaaatccg tgaggtactc 220321 acgaagttga acatttctat ccccaaggtg tccaaactgt ggttgatatg ttctttgaat 220381 ggttgcttat tttccacagc tggaagctcg tctaaccagc tgaaatcgat gctcactcgt 220441 ttctgctctt ttatttgtcg tcttatggtt tctctcaatt ccatgatttc cgaaactaaa 220501 tttactctat ctactttctc tctgtctaaa taaattttgt tcaacgtatt attatccttt 220561 atttgatata gtttgagctc catattcttc aaacggttta ctaggttgaa attttcttct 220621 ttcagcttgt taagaatttc tgttttgcca caattttcct catttttgtt atttaactct 220681 actttgagtg ttttgatatt ctcttcaagg gttttcctct ctaaatccct cccaataata 220741 attttaattt ttgtttccaa ttcagttagc atattttcct tttggaccag tacttctttg 220801 agtcgaatgt tctcttcatt caagcgatcg cttaataacg agtttgaaaa attgccctcc 220861 ttaatattac attgactttc tgaatcactt gtttgttgac tgggttgctc aggaaatata 220921 gttatgtttt ctaagagact ttctattcct tgaaaaaata cctctagttt tttcaaagaa 220981 gaaatacgtt tgtaatcttg tcgcaaaaac agtgcatctg aaaaaagtat cgttaagata 221041 gaggacaggg ttatatcaca ggaaggatat aaaaataacc tattgtcttg tttcgaaatt 221101 tcttcctttc cgataagttt atctattctg gcaataagtg aaagtgatct ctcgtaaagg 221161 gaaccaataa gacatagggt atcattgtca ttgaaattgc tgttcgttct aagaaaagcc 221221 aacagcttcg gaacagttgt ttccaatatc ggatgaagta tttttagtat caaggtcaca 221281 tccttatcta gaaacttatt atcttctaaa aactgacaaa tggaaaaggc ggtttcctgt 221341 ttagaagaaa acttcctttg caaaaactcg cttagccaca tcgaaatcgg agcaatattt 221401 actttgaaac attgtaatgt cgtttccagg tgatcgggag tattctttat ggtgtaaata 221461 tgaagcgcat aactgataga gctcaacact tttagaatta tatggatttc aatattctcc 221521 aactttccaa aattttcact ttcgattact tcggctaaat attgcaattg agaggaaaga 221581 gccgccaaat gtggttgtgc aaatggctca tatatttggt aaaatttctt tagcaattta 221641 ttttgatata attcctcctg taaagtgttc acttttagtt caagactttg aaatttgtga 221701 gatgttttgg cttcaataga ttccaatgtt gcttttaatc ttgaattttc ttcgatatat 221761 gtgcctgcta tctccttttc attttccaat gcagattgca aattacttaa ttgcagtctc 221821 agttcttgct cgagttgctc ataggtaatt cttaaatttt catccaattt ttcttttgcc 221881 tgtagttcct ccaactcatt gtttaaagcc tttatattac ttgtgagtag gatattatca 221941 ttagtcaatt tatcaacaat attagatgat ttactttgag cttcaatctg caaggcaagg 222001 tcgccgattg tattattagt ctgttgcaat tgcagaccta aatccgatat ttttttagat 222061 aatactgcat tttcttctaa taactgagta ttctcctcga gcaggtcctc ttgcaccttc 222121 atagctttat catatgacaa ctttgtttgg tcgagtagtc cctgaagaag atggctcctt 222181 tctaacagtg tgcctttgtc gagatccggt gccattacac tatctgaagc atctaatagg 222241 tgattgaaat tatccaaatg agttttcata ttaccatttt ccactttcag ttctttgact 222301 agtttatcca atcttgagat tttagacaat agaacagttt cattagtact cagcttttca 222361 acggaagttt tcagctcatg attttctatt ttaattttat ttaatttgga cgccaatgat 222421 tcacatttta cttgtagatt cttaattgtt tcttgcgctg cattaccatt tagcaaacta 222481 tgctcatcgt catctggttt ataaaactgc aacgtatctt tcttgcagaa aagaccataa 222541 taaccaccat ttgaattagc tttcttcagg tcgatatcaa agtaacgaat accgttagcg 222601 cttccatcat tctttcctaa cggtttatct agttcaatgc cgtaccatat gccttttgca 222661 aattgagttt ccccaatgaa tttcacccgc cccttcatct cgttgactag aactgtgtcc 222721 tgtaagctta tcttctgcat atttgtgtca acttgaacac ctgcattgcg catttgtcca 222781 aggctgtact gcgaggttga tggagatcga atctagaata gtattatgta ctttgcaaaa 222841 gtaaagtaca acataaagtc tagcagcata tgagtaactc tctacagtta cgccaacaat 222901 ctcagtgtgg aggttagagt aaaaagaaag caccttacaa ctgtacgttt acataagtga 222961 cttttcaaca tatatgcatt ttttgttaag cattgtaaaa tacccggttg aaaagcgaca 223021 tgaaaaataa cgacatgtta gattcaaaag tacctactgc tctttaacag ctacttaagg 223081 attacctgat aagagtaatc caccgtaaag aacattatca gcaacaaaat ttgtaatcca 223141 tcatgtctgg aagctatcaa catttatcaa acgttggatc gcgtgttatg aaaagattgg 223201 ggaatcgacc caaaaacttt cttcctcata gtgaaaagtt cattaaaaaa tctacgcctg 223261 agttcatgaa gtcagattta aaggaagtag atgagaaaac tagtttcaag agtgaaaaag 223321 aatggaagtt tatacctggc gacagagtag tagtaatgag cggggcttcc aaaggaaata 223381 tagctgtaat taaatctttc gataaaagaa caaattcatt catattagat gagaatgggc 223441 ccacaaagac tgttccagtt cctaaacaat tctggcttga aggccaaaca tctcacatga 223501 taacaattcc agtttcaatt ttgggaaagg atttaaggct agttgctgat attgacgatg 223561 aaaagacccc aggaaagaca agaacggtgg cagtaaggga tgtttccttc aatggttcct 223621 actatgatgc agactacaaa aaggtaatgc catatagatg cgtaaagggt caaccagact 223681 tgatcattcc atggcctaaa ccagacccaa ttgatgtgca aacgaacttg gctaccgatc 223741 ctgtaattgc tagagaacaa acattttggg tcgattccgt agtgagaaac cctattccaa 223801 aaaaggcaat accaagtatt cgcaatcctc attctaagta caaaaggggt accttgacag 223861 cgaaagatat agctaagcta gtagcacctg agatgcccct aacagaggta agaaaaagcc 223921 atttggcaga aaaaaaggag ttggctgaga gagaagtacc aaaactaact gaagaggaca 223981 tggaagctat tggggcgagg gtttttgaat ttttggaaaa acaaaaaaga gaataaatgt 224041 accaagtgta tgcactctat ttttatattt gattctctag tgtgattttt ttaatcagta 224101 tatccccttc actattcacg tagtaaataa gttatattcg acctgtatat atgaaagcat 224161 aaagtaaagt tcaaagaata ttcagatatt gatgtgggca aacgtgatga cttcaaatta 224221 caaaatcttt tctttaaaaa taaattatgt gcgtatgtac attattttta accaataaaa 224281 gggtttaaat atttatttac aagattaatg actgcccttt aagcgttgtc tctttatctc 224341 attgtactaa tgctaaaatc gttcctgtgg tcgctttgct tcaccaggat atatccaatc 224401 ccagcggcct tttttatgta taatggctag gattagaatt gccggtaggt gcaatacact 224461 agccataaaa gttttccttg cataaatgtt ggctacactt agacctttat taaacttgac 224521 gttatctttt aatgtttttg cagaatagtt gattctttgt tgccaataga atttgaaagc 224581 ccagaacgtt agccaggcat ttataagtcc ggaatctatt tggtagtacc aatctgtgat 224641 attaaaataa gacaatccga aacataaagg gaacattagg atagagtatc tcaacgacac 224701 acgggcgttt aggagcggat ttttccatgc agtcataacg tatccggcat ttttgtattc 224761 atttctaatg ttatgactca acgtattaaa gtgtgggaat tgccaagcaa acaatagacc 224821 agcaaggcac caagatcccg gatgtgaaag cggacttgcg gctgcccatc ccattagagg 224881 aggtaccatt cctactaggg cacctaacca tgtgttaatg atatgctttc ttttcataga 224941 cgtataggcc cagccatata acgcgatatt tgaagcacca agaatagcaa cggtaggatt 225001 aacaccaaag tacaagatag atactcctaa tgttccgata agtgcggcaa actcgaatgc 225061 ctgggtaggt gtaacatcac ctctaacaac gggcctcgcc tgagttctca ccatttgtct 225121 atcaaattct ggctctctgc ccatatttat agcgtttgca gaaccggaac acaaagtagt 225181 gcctactgtt aaacataaca attcattgac ggaggctgga tatggagata aagcatacga 225241 acaaatggca cttaacatca ctagaatggt gagtcggggc ttggtcaact gaagatatgg 225301 cataattacc ttcttcttta aagttttcat attcagccct tcgctgattg cgtgagatgg 225361 tctcttagat tttcttacca tcgggtctac aagtttgaca ttaaatggaa gttgtgtgct 225421 tgcatcggta gtagcttcgc ttccacttga agttgatata tcatctgtgc atcttagcgt 225481 tttcatggca gtcgattcaa cctttttatt gcaattagag gttctatcac catatccaaa 225541 attgggagta aattctatcg gcgcagtgtt tatatgttgc tgtttcccgc catgattccg 225601 actaatataa cgaactccat taaatcgaat ttttatttga gtatcgtgca gctgtgtacc 225661 aatttgtaag tatatattcc ctttattatg agcaagaaca tttctcatca agtgagcata 225721 tgttcgagga aagtaactca tctaaagagg aaaaaaggag aaatcgaaaa aaagagatac 225781 tataggccta aaataaaaag accccgctat gaggaatatt aatcacgccc gaatcacgtc 225841 tattgcagat atcaagaatt ttcttctttg attaatctca cttgcggtgg atttacgtca 225901 atgggcttgc aagcataaaa aagtcatttt attattccct ttgaacagcg cgcgggcacg 225961 agaaagctgc cctatataaa caaagatcga gtctttttgg cttggatgat gtttaaaata 226021 ctttaaaaag tgaagacaaa aactatcttt atttccttaa gttataatta ttgatgtatc 226081 aaatataaat atctatatgt gagttttgta attaaaaata tggcaggaat atgaaaaata 226141 cataacatca atgtctttat tcatgatttc agttcttgtt ccaacctaaa tctactgcct 226201 cttcatatgt tgggtagtcg gtataacctt ccgcggacat ggtgtagaag gtacttctgt 226261 catacttgtt caatggcagg ccctcttcta aacggtagac taaatctggg ttagagatga 226321 agaatctacc atagcctatc aaggttctgg gatcctttac ttgttctcta accacttctg 226381 gatgaagagc gtaattacca gctctgatga ttggaccctt ccatatagag taggcaaaat 226441 cgttagtacc ctcggaatat tctccttcgc cctccaccaa cgatgggtcc gtgacacgtg 226501 gttcaacgag gtgcacaaag gccaaacgct taccagcctt tgccctcttc tctaattcac 226561 ccaaaacata cgaatattga gcgataatac ctggttcagc acccccagac atactgttaa 226621 aagtgccgta cggcgacaac ctcaaaccca cccgttcagg accgatagtt tcgataagag 226681 catcgacaac ctccagtgta aagcgggccc tgttttcgat cgttccgccg tattcgtcgg 226741 tcctcttatt agaatgtgga tccaagaact gattcaacaa gtacccattg gcgctatgaa 226801 tttctacacc atcggcgcca gccgcgatag aattcttagc cgcatggatg taatccttga 226861 tatactgttt aatgtcgtct ttagtcaaac tatgttcgag attattcgca tctttggcct 226921 tttcttgtaa cgtagcattc atatacactc tgtcagatgc acagtcatag cgtaacccgt 226981 ctcttgccaa tacgtctggg aaggatgccc agcctaaaga ccaaagttgt acccacgcga 227041 acgactgaca atcatggatg gctaaaaaga tattcttcca ctcagcgacc tgctcatcag 227101 accaaatccc aggggcgttg tcatagccgc cggcttgagg ggaaataaac gtaccttccg 227161 tgatgatcat ggtaccaggt ctttgagcac gctgaccata atacacagca gcccactcct 227221 tatttggaat atttccgggg tgagtggccc tcattctggt caatgggggc ataaccgcac 227281 gatgtgcaag ctgagtgtta ccaatcttaa ttggttcaaa aaggtttgtg tctcttaggg 227341 agatcggctc aaaacctttt acaaatggca tcttctaaat ttaaacttcg ctatactgaa 227401 ctacagttgt tgtatatatc aagtacgtac ttttttgcat atgatgggca agaatcaagc 227461 acagttcaca acccttatat aggttcgagt tgtcctactt acaacactgt gcttagtaat 227521 ggttattgcg actttatcct tgttctgaac ggagttatat caggaacgca aactgcttac 227581 taaggagccc ttctaaggag ccctccgcaa ataataggat cggcaatttc agacggagga 227641 cggagccgcc taagtgccaa gaacattaaa gaagaaagaa ataaaccttg agcggctaca 227701 cgaaacagtg gtcaagagta gaatctctga aacgtcgaac cctctttgtc agttatcgcg 227761 ggcatattct gagaagaagc aatatacaac aaacgagcag gacagattaa aattttcaag 227821 gcgaggtaag ctgtgccaga tcagtgtggg acgacgctca gtagttggcg atcgaagcac 227881 gtgatcagtt ttccacatcc gtgatttggc gcaaattacc atgtgagcgt gcgggaataa 227941 gctcctttat ttgcggagcg acaaaggaaa cgagaccata ttaccctacc ttccttgttt 228001 tattttactt ttttttctaa ttttaatttt cttcgttcct tcaactgtat gtaccctttt 228061 tctaccggaa ataagacggt cgtagtgtcc gcgtttttgg ttctttaacg acaagacatc 228121 agtgccttct cgcatttttg ttgaattgta ttgtattatg ctcgatgttt ccagaacgat 228181 atatacatct gagagtttat atatcaacga tcattttctt gttgcagtaa gctataatag 228241 acgcgtcaaa tagtctaacc agtctaaatc tcatcagcca cacacacgta catcggaata 228301 ttatagagaa caaatgtcct tcattaaaaa cttgttattt ggaggtgtta aaacaagtga 228361 ggatccaacc gggctcacag gtaacggggc ctcaaacaca aacgattcta ataaaggtag 228421 tgaaccggta gtagcgggta atttctttcc taggacgctt tccaaattta acggccacga 228481 cgatgaaaaa atatttattg ctattagggg caaagtatac gactgcacaa gagggaggca 228541 gttttacggt ccaagcgggc catacactaa ctttgcaggc catgatgcgt cgcgtggtct 228601 tgcattgaac tccttcgatc tggacgttat taaagattgg gatcagccta tcgatccctt 228661 agatgatctg acaaaagaac agattgacgc actggatgag tggcaagagc attttgagaa 228721 taagtaccca tgcattggta ctctgattcc ggagcctggc gtgaacgtat gacgattgag 228781 ctccgcacat tatttattaa tagcaaacac caaggaaagg gaaaaaggaa ggggcgtggt 228841 ggacgatgat atatgtatac atatacatat ctatattttg aaaaaatctt ctatataacg 228901 gttgtataga aataattact tatttatgaa ttagtacaaa atatacaaag catgctgctg 228961 ttcggaacgt gacgaaaaca gtagcttaaa ctgtatattt tttgtgatac tgtgcggctg 229021 aaacagggaa caatatcatt agaactgcac aaatgcttct ctagggatgc cattcatgct 229081 actctgaaaa ccctttatgg caacttcata gttccagtta ctttgctcgg ccaacataaa 229141 cgtgtattct gcattcaatt tcgtttccaa atgtagttta ttcagcagct cgagttgtac 229201 gggatttagc cgcgactgga catctggagg tagttgcaaa gtgggagcca tgaccatggc 229261 tccttggggt gcgccgggaa tgctcatccc tcctggtacc actgaaggtt gtggctgcgg 229321 tggtgtcgtt atatttgggt tcatgcttgc gacctgtggt aggaccgagg cctgttgctg 229381 tggaggctgt gctattgcaa tagatgcagt tttccaagcg cctgtggaat acgctcttac 229441 agttaacaga tcagatgcga ttatgacact attattcatt ggaacaatta cccaggttct 229501 atcaaaggat tttttggata acttattatt tgatgtggag ttgtaaccat gattgtatct 229561 tctattcttt tgatagttat ttttccccgt ttttttattg gattccagtt caggcttgcc 229621 agtctcttca aaaaatccgt gcaacgtaat aacgaaccca tttatttgag gataactaat 229681 tgtttccatt gagtattcat tgggttgttc ttgtaaatgg tgctttgttt tcggcaaagt 229741 cttgaatata ctattaatgg actcttgccc gattgacaat ctctgctgga tagatttttc 229801 actggacact ttggatatat tacgtgagga cgacatgtaa taaccaaatg ctggagtttg 229861 gtccgaatct gttaccgtag atggaggaat agtagaatcc acggaaacag aaaactggga 229921 ttggggcgaa tacaaattta acagttgttc tctattatta tcccatagat tcaaaaagtt 229981 agttgcaaag tctgtagatg attgccctaa tgcatcgttt tcgaaaaaaa actgttgaat 230041 cttcatcggt aatgagtaaa cggtttgcaa tttttgttcg tctctcacaa tcacgttatc 230101 tagtacaacc aatttcggaa ataatcttaa catttcagtg cgatacaact tatcggtggt 230161 tatcgggtta tttgtcatca aaagctctct tagatctttg aatttgttct tccaaacttc 230221 tagcgatcta aatctaaaaa tctgattgtt ggccagacag aggtttttca aattaggaaa 230281 tgtttgagcc aatgtggaaa ttgctgagat gtccttaagt tggttgtcag caagattgac 230341 actttccact atcaaacttt tttctgtaga agccagtttc atcattgctg gaaacatctt 230401 agactgggtg gagatggaac taaagacgcc cttttgaatt agctcgggat ctgaatgtaa 230461 agcgcccaaa tttagtaatt ttgtttgtgg gtcatacctc ttaaggagca cccccctcaa 230521 gaacgaaatg gtgtctgaag ttcccgcaga ggccccattg ttatctaaaa gttcgaactt 230581 taaattactg cctgcaaacc ggacaccgtt ccatttcatt aacgattctg cttctgcctt 230641 tgagttgaca tatccaataa ctaaaggtcc ttccacatga gcgtcataaa cagctactcg 230701 agcgttgcgg cttataaaat taatcaaatc gttcatggtt gcattctgcc agttcctcac 230761 gctaatcttt attctatttt gttgcatctg ctgttgagcc atcatattga tatttccaac 230821 attgtgaaat ccgctcattt tttttgctgc tattagcgat gcagaatttt taacgattta 230881 ttttactctt ccttcttaga gtaagtatgt cttcaacagt ctgttactat ttttttttct 230941 acatactcaa ttcagctctt actgaaattt tcttctggaa aaaaaaggaa gacgggtaat 231001 gatgatctta tataacagta taatctgtag gtatatttat cgttagaatc ctctacgaaa 231061 ggcaagtggg catggatttc tagcttttga agccgcgttt aagtttcttc agaattaata 231121 ttcgtagaaa ttttctgttc tttgcttctt ttctgagctt tggtggaata aacttggttc 231181 cattcaactt aaaggaagga ggaagtactg ttcaaaatga cagttttata cacatctgca 231241 tcgctgaaaa aaatgaagtg cttggcattc aacatgggca tgaattgcgt acgaacagta 231301 tctcatgcaa gaagtggagg tgcaaaattt ggaggacgga atgtatttaa tatatttgac 231361 tcaaaaactc ctgattcagt gcgtataaag gccttcaaaa acacaatata ccagtctgcc 231421 atgggcaaag gtaagaccaa gttttctgca atggaaatta atctcataac aagtctagtg 231481 cgcggatata aaggagaagg taagaagaac gcgataaatc ctctccaaac taacgtgcaa 231541 attcttaaca aattattact aacacatcga ttaacagaca aagacatatt agaaggaatg 231601 aacctggcag ccggtcctgt caatgttgct attcctcgag acataacacc gcaggaagaa 231661 aagaagaaag ttgaactaag aaatcgaaaa gcagagaata tggatcttca cccgagcagg 231721 aagatgcata ttaaggaact tctacactct ttgaacttag atatgtgtaa tgatgaggag 231781 gtttatcaga aaatatcact ttacttacag aaaaatgagg aaagcaggac ttcagtgggt 231841 gcctcgcaac aaaaccacgt agatatcgat ataaactccc taaaacgcta tctacaaaat 231901 attgaaaaga aggcacgtca aaaaagtgcc atcgataaac aaaaaaagaa tcaagctcgt 231961 atatatcaat ggaatactca atccttctcc gaaatagtac ccttatcagc tggaaatatc 232021 ttattcaaaa gggaacccaa tcgcttatgg aaacgtttac aaaatggaat aagtgtattt 232081 ttaggttcaa acggaggagg aaaaaagagt aaaactacta aaaaagtact tcaagggaat 232141 aacatattgt tacactcatt agaaaacaat aaggatatga ccctgtcaaa caactttgat 232201 cacagtgtct ttaacatcaa ttttacggac ttatttggcg ttattaatgc atctgggtcc 232261 ccaccagata gagttttgaa cgaaattaat gagatcgaat taaaaggttg gaaatgtgtg 232321 gggaacttat acgataataa taaaattgta gtttttcaaa gtagcaatcc actcttagag 232381 gatacgaaga ttcctcaaaa gtctttcact aattcaaaga gattccttat ttcactctca 232441 gcattgctgg cctccttttt tgcatattat agataccgtc tatctcaacg tcaagaatca 232501 aagaaatgat ttttttcttt cttgtatata acaacgttat acatagaaac aaataactac 232561 tcatcatttt gcgagacata tctgtgtcta gattaccaat catttagaga tattaatgct 232621 tcttcccttt gaacagattg attatctctc aagtatcttt ctgctttgac acgagagtaa 232681 aatactggac agtcatatga attgcattta ctagctatat ggtcattttc gatgcctgca 232741 tcggaagtgt aacgataact gcacgtcctg cacacggtct ttagtgtttg gtattctttt 232801 tgtctcttta atttctttat gagaaatgat aaggttgtgg tgcttctttt ctctaaacag 232861 tcatcacata actgaagtga acatatttta gtcaattctt caccacaatt acaacatgtt 232921 gcagaagttc ctactcttgt tatgttttcc acttttgtag tagttgtgct cgcccttttg 232981 gattttacta tttcctgagc ccagttgcca acatttatac caatcaaatt gaacaatcta 233041 tcaagaggag gtatcagaat tttgtttata taatactccg aatctaactc taaattctca 233101 ccttctaaga actcttctgg tgatacgcat ctttcccgaa gcagttgtcc ttgctttcct 233161 ttaacaacaa ggtaaggtat acgctccttg tattggggtt ctgctctatg gtcttcattt 233221 attcttcttt ttacaaccac ggcacctgca ggggctgtct tttcgctttt atacgctcct 233281 aatttaactt cttttgcaaa acaaaaatct tgggcagata cctttcctat ttgaatctta 233341 aaaaattcat tttgaagata cttttttatt tttgacaggt ctttggtttg aaaaagtaat 233401 cgaatacatt tttcaataat cttctgctgg gctgggatac catcccttct aacagtttca 233461 atacccttag catcaaaaat aggaagggtc tgcgaaggac tttcatagga aaatcctacg 233521 tacctttttt tgctaattaa tatggaggga tggtatactt tttcaaactt caaaaagatt 233581 ggttttggat tgttttgagt aactctttct gccatagcat gtcctataga aaaagcctca 233641 atagcagttt ttccaggtag atatacaaat aaactatctg tgtctccata gacaactttg 233701 gcgttccaag tttcatcttt ctcaataata tctattgctt tctccaatgt ttctctgcct 233761 gtttgtacaa tgctatcagc taaatcagag catggcattc gtccagaaaa tgaagctgat 233821 gtataaccgt aggtgacatt cgccaataat tttagtgcta actgtttgtt attcaaaagc 233881 ctttttaggg tagtgttgtc atcacctatt tcgttcattg ttttctttat catcactctg 233941 acatcaagga tatctgttaa cattttggat aacgttgatt ttctaacaga ggtcttggca 234001 taaacaacac catttggagc gatagttaca tcatttttta ataaagctaa aatgtttctt 234061 ggtaatgaaa acttagatac tccaaggtta ttttccgtta agtttatttc tcgcactctt 234121 cctatcatag tcgaatagca atagttgtat ccaatcataa tggatggata caatgattgg 234181 aaatccagca caattaaagg acttttgtag aaagcagatt ctggctccat aaccaaaggc 234241 acacattcaa gtgctttttg cttacgaaca tcctttttgc ctggagaaag aaggataaaa 234301 ctttcggact tgcatattcg gattaaaaaa gactcaactt taaattgtga tcctctgtaa 234361 tatacagaat ggaaatctat tcctatcaat cttgcctgtt cgatatttcg agcaatgtaa 234421 tcctgctttc ttaatagttg tatatttatc tgagctcttg ataaccaata atttaacaca 234481 gtctttaatt cggttgtgct ctttttagcg ttccacatat tagttaatga ctcaaatgaa 234541 aagtgaggta atcgtttatg gaggatattg aacgcagcac tttcaatagt atattgcgtt 234601 aaatttacgt cggacctcaa cgctctccat atattaatca tatgtcttcc ggtaatcata 234661 attcctgagg aatgggcata tccccaagta tctgacaact tcgtcttaat ttggcatttg 234721 actctggcaa gttccctgac aatgtcaaat tgatgtattt tttgacacct ttcaattata 234781 taaccccacg aaaaattatg tatttcgaaa ccggaaagaa tatcaggatc aagaagtaat 234841 accaaatcag ttagagcctc aaacatttca aattcacttt catagaacat cacgggaatt 234901 tcgttaatac aatgttgaat tttagtagga aatgtactat cctcagaagc tttgtggact 234961 atcataatcc cttcgtaagc gatatccaaa tctaaaggga aagtttcttc ttcaagacac 235021 catataatca tggaaacttc atctattgca gggtctggaa ttttatcact tctcgtgttt 235081 gcatgaatct caagtgtcag atgagtaaga gaatcgtgaa cgctactttt ttttcttttt 235141 tgttttccag aaacgtcact agcaaatttg tataaaaact tactatgagg ggtgtgcatg 235201 cttatctgag actcagtttt tttgtttccc atcgagggta ctttattgta ccatttttga 235261 acagcatcat acgtaggtgg ttttaacgca tatttccagg aggaaaacat gtcgaaagtt 235321 ggcttgttat aaactgatac ggtctctccc ccaaattgga cgggtattct cgttgataca 235381 tgtgtcgagc ttatttcaaa cctcttacct gcgtacgcgt aaggtttatt ttctagatca 235441 actggattcg aaaagaaagg gtccttatag tctatttttg ggaatccctc gtcttccaat 235501 ttattcagaa tatcttgata accgaaagga ggctcaccat aaacaaaggc tctttttcca 235561 tagcgtaatc ccgcagccat aaccttcttt cttttccgag acagcaacga tgttttatta 235621 gcagaaacag atgatctaag ttttcgttta cttgccatat tttgcgtcat agcacaatcc 235681 attgaaaaat ttatcgtatt gtgatatttt gtttgatgat ctaatagtat agtagaatct 235741 ttcggagacg caatgctttc cggtaaccat gaataagacc gagactttat attgcttcct 235801 tttacacctt cgttctcatt atcaacacca catatctcgt attcggtgaa cgatgcatta 235861 acttggtcgt cgttcttttt atcttgcata ctattattgt ttatttcaat ctgtggaagc 235921 cttggccaca attgcggtaa tgcttcatag ggcgtattta tggctgagaa tttttgattc 235981 ttatctataa agttctcaaa atttggtatt tgaccatcaa aagtacttgt tttatgttgt 236041 gctttcttat aaaacgcttc gaactctcca gaagattgcc attgatgacc actcacatgg 236101 cgctttgttt ctggtggttc tttatattcc ttcaaggaca actcctctcg ttgcatggta 236161 agttcattta tcatgtccct agcagaggat acatatggtt tgacaggtat gtcagaaata 236221 tctcccagtt tttccaaaaa gtcgtgatgt atatctctat gctgtaactt ttctctattt 236281 ttgatgaatt gcggtagtat atctatctca atcaatccat ttccaacccg tggaaaatcc 236341 cttctactga gtacgttaca cttgaagtca caaaatcgat ctagtaacaa ctgaagatca 236401 tcattaattg tcagcttatc tatgtccagt atactattta aaacaggaga gcgaaaataa 236461 cacctatcca cgtttatcca tgaacatcca aataagttaa aatctgcggt ccattgtagc 236521 aagtaaggaa tatgtgattc ataaatttcg aatttctttc cgaaaatctt gccatctcta 236581 atcaattccg aaatcctact tagacaagaa ggattaagca aagaaatttt gtaaaacaga 236641 ttccagccaa cgtggtaacc ataaaatggt atacccttta caacagagac atcagcgaca 236701 aaattgagat ttccaagttt gtcgccggct aaatcgtgtt tatcatcttt tttcctttta 236761 aaggatgccc taatttttac ttccagcgtt ttatgaactt gggcacatct ttggtgtctc 236821 aatgtactcg tgtcagttat ttgtccatca tacttgatga acatgtaagg tagaatgcca 236881 tggacgtggc acaatacttg atgccctgtg ggtaaagcac caaacaccct gatgtttggg 236941 acctgtgaaa actggtttaa gggcaggctt tcaccgtgcg atgggtccaa aaaggtgggt 237001 tttgacatat agtagtcttg attatttagc tggattctaa aatagtctga tttagaggat 237061 gatctaaccg tatcgctctg tattgtgtcg ttcgactccc tcgacatttc caaacatttt 237121 atttcgccac aacttgtagt tttgtattga ctcaaatact ttctcttgtt ttgtgcttct 237181 attacagaga tggctttttt cttcaagtac actatttcta gacgcactgc actcgtcaaa 237241 aaaatgattc aaggtgaaaa taaaggggtg ttagtgaata cttatcaaga agagacatac 237301 ataattgtac tgctgtgcat tttcctactt gactttcatg attatgaata gtacaaacac 237361 agttgtatat atcaaagtta agggtaggag accacaggga ttcttggatc ctcccaaatt 237421 tgagtggaat ggaacaaagg agcgacagct ttggacaatg gtatcaaatt tgaattattc 237481 acaagatcaa atagattggc agaatttatc aaaaatattt gaaacgcctg aattttttct 237541 taaaaagaga acatataaat tatttgctga acacttagag cttttacaac tacaattgga 237601 gaaaaaaaga gatcttgaga agtattcaaa tgatcaagtg aatgaaggga tgtctgattt 237661 aatacataaa tataccccta ctttacaaaa tgataatcta ttaaatgtat ccgcaagccc 237721 actgaccacg gaaagacagg attctgaaga agttgagaca gaagtaacaa atgaggcgtt 237781 acaacatttg caaacttcca aaattttgaa cattcacaag aaaacatcgg atagtgagaa 237841 taagcctaat gacaaattgg ataaggatgg tattaataaa gaaatggagt gcggtagttc 237901 agatgacgat ttatcttcga gcttaagtgt tagtaaatct gcgttggaag aagcgctaat 237961 ggacagattg caattctgat ttacatcttt cacaagcaca atcaaaaaac caactgtcgg 238021 ccaaaaaggc ccggcgtttt actgttggta agtccagtac cccggaataa tcgatacaga 238081 tctgctcatc cttttttata tctctattca tagtgaatag cattgaatta cctttacgat 238141 atttcgttat attggggtta caagagtggt tgaaatagga ggcttctgga aatacccagt 238201 atccaaaata ttctctgctg tctgaggctt cgccctcttg ccataaacca aaagcattcc 238261 catattcagt acctaatata tgtctcaata gcggtatgga gagcattcta tgcaaatgtg 238321 aaggtaatag aatatagagt gtttgaaata ctaatttttg aaagtgcagt aagacaggaa 238381 atttagatat tttgctaagc tcattcgatt gtaacatatt gaaagctcgg tatgttatgc 238441 actgaggatc catatattta agattaaaca aactctcgca cacaaaccta atgcagcaat 238501 attcatcttc gcaagtgggt ggtaattgat ttattctctt cgcagatttc atgttgttga 238561 tgcgcggtat ccatttactt tcaatctcat cccatgaaga ctgtatgaca ttttccgaaa 238621 ttaagataga gtttaatttt tcctcctgtt cagaggtata attatatctt ttcagcatgc 238681 ttggaaaatg atgcagtaat atctcataac attcaattaa ttcaatgata tttggtattt 238741 gaagataaga agttctgcaa tgttctgaac agaaccacag tccagcgccc agaaacttct 238801 tagggttaat ttggtagtgt gcattacaaa ccaaatctct caggtaatcg tagtttagtt 238861 tgtacttcat agttttcgca ttagcgtatg cgaaacaatt gtgacaaact tccttcctga 238921 actcatagga aatagatgtt cctgtaaaat tactgacttg caagactgtt gtccctttag 238981 gaatattacc attactgaaa caagccctac cgccccattt agtttgccta acctggaaaa 239041 atggggaaat ttcatgtacg tctccatcaa tagtcatttt taaattttag gttattttgt 239101 gtttgcatat ataaatggta tatatatata tatatatatt catataaatc tagggctaca 239161 tttataatat cagagataca taaaacggta atgcaacagt ggagcagtat tgtatcgcac 239221 gtttcttttt tgtttttgtt ttttaaattt ttccaggttt tgacaacgtg atgaggtaat 239281 cttctgtttt gcatatccgc gcaatttaaa atgcaggcga caaaccttgt tccaggatta 239341 aggttctctt tacttcaatt ctgcaatggg taccatagaa ggtctcccgt gggcgcattc 239401 gaatgggtta tggcatcgcg agagcttgct aattaaaatt atgcactctt gccgggttaa 239461 ttcatctcca aacataacag cagatctgca tgccttgctg ttaagaattt catgaaagac 239521 cgttggaacg cagcttgagt acttccacca atataattta tcaaccgaag tgtagttttc 239581 gaaatgggat aaatccattg gaagtttttt gaaatccttc aggtcatgag catgttgcag 239641 caagaccatt tttaagtagt ctttatcccc gttatatttg gaagttaaca tctcaggcag 239701 tgttttaatt tccaaaagtg aggtttccat tgttccctca attgtttcat agccaattcc 239761 ccacttttta aattcacttt gataatgctt aaataagtca gcctcagtac gatcaacttc 239821 aatgcaacaa tccttgaggt ctcgtgcaac aaaagttccg gttacaactt ctgtcaacag 239881 gctataaaat agctcttcta gtcttatcct ctcatcgcaa gcatgttgat caactagaac 239941 taatagtggg caattatgaa tagattggtc taaacaacgt atgagaataa attttttatc 240001 tacttgatta atcacttcat attttgccag gacagatctt gatattgaaa aatctgttat 240061 ggtttttcct atactgtcat aatcttctgt aaaaccacta tcgtagggcc tggaagagag 240121 tttattccgt aaccttgatt tctgaccgtc gattcttata ttcttgattt tttcgtagtt 240181 tattgtacta ttgtttattc tacatccatt gacagcgggt tttcctatgt atgaattaat 240241 gcgtgcaatc ttcatttttg aatttaatac ttgattacgt ttactgattt ggattcgact 240301 atcaggcaat gttgccgtct tctgtgaaca attgactatt tcgaaagatg aatctgattt 240361 atcaggcgtt aagtatcctt gaaatgtcag aaaggagcga atggtcttaa cgatcaatgg 240421 ttcaatggta cgtatatggg aaggcttaac aattttcttt gctggatctt gtaacaggtc 240481 atcgatagtt tgggggcacc gaacatcaag gatgaagacg ggatgtgatc gatacggttt 240541 tcccacgctt ttagttttga gtaaactcat gcctttctcc ccgaaatctt gtgcttggaa 240601 taaagaatcg acgtatcctt gaaaggcgct gtccgcataa cgtctgccat tgatatatat 240661 aaattgaaga tccttcaatc caacgggcat cttcgatatg atcccttcaa tctgatattc 240721 attaaacttc aaggaaactt tcttaagcat atccggtggt attattgccc caaacacatt 240781 tctcagtact tgagacattt gctggtgctt tgttaacccc tcagttatgt tctttgagcg 240841 gaaaagaact tctgtattga ttctgagttt gtctgtatat tgtacgttga gtgaaatcat 240901 cgggtgcatt accagtatct gtagcatatc tgcctttatt gtgttaaaag tcttgaaagg 240961 gggttcttcc tttagtattc tgcgccggac aggtaaatta tacagcatat cttcaacaat 241021 aacaacagta ccagactttg ttcggctcca aggacaaatt ttccaaaaag gatctattgg 241081 gagtatggta ttctcactca acatgacgct tttggatgga aattttctca tccatgcaga 241141 gttgtaatcc tttttcttgg aacaaacaaa cagattagag acattagaaa tgctatatag 241201 ggcgtctcct ctgtaaccgt aggttttcat cgttactaaa tcattcatct ttcgtatttt 241261 ggaagtataa ttttgtgtgg ccaatatatt taggtcactt cgagtcaaac caataccatc 241321 atcgtaaact gcaaagctca aattagggag gtcgatcatg acgtcgatag tggtagcgtg 241381 tgcatctaca gaattttgaa ctatttctct aaccgctgat gctagcgata ccgtgcatgc 241441 ctgagattta agtctttcag aaacatcaga atctaatttc ctaatatgct ggctcatttt 241501 ctttttgagt tgacgagttc acgttcattc ttccttgaaa gcctcgctgg tttatgtatc 241561 ggtggttgaa atcatcattc gatgtttatt gcaaactatt gatctttttt tcctgcccct 241621 tctcgtggcg ctcgcaaata aacgcaaact aaatataagc gtacaaacag acagattttg 241681 tgctacttat tgattattta gaaaagctac tattgttctt gaaagtcata atagaactac 241741 ttatatatgt atcaatgggg ttgaatttgc gctttatgta ttttttaagg aatgatatga 241801 aagttgtctc tagtctattt attgaatcgt aaatcaaaaa atactagtga tcccatatag 241861 gataactagt aaaggtttcg ttaaaagtag ctttttttct cgattcaacg tcacgcatta 241921 aatgtgggta ccgttgttag cagaacctgt aacattacta gcatcggcag ttatagtaac 241981 gtatttaaca acaggctccg ccgtagtagt aaccacttcg gtaactgcag cagctgtaac 242041 tgtaacatac ttggtagacg cactacagta ctgttcatcg gcggatgtgg tttgaatcat 242101 ctgagattga tgttcagcag agactaactt ttctaaggca tcaacattgg aggcggcgtc 242161 cccagctgtg gatgtcgcta ttgtattact agcttgggaa ttatatacag taaccaataa 242221 ggttgaggtc aaagtagagg tgtatgtact gcccgattcg gttactgtag aagcaatttc 242281 tgtgacgctc gtggaaatct gttcagcctt ctcgttggcg gattccgtag atagagttat 242341 tatgtaagta gaggtcagag tagacgtgta ggtggtgtct gtgtcagaat aggtggtggt 242401 gtattcattt gtggacgtag ttaggctagg cgtgcttgca gtaggtgtac ttgcagtagg 242461 tgtactaata atagcagctg attgggaggt agtgaaccag taggtagagt aaaaagtaga 242521 tgttatgtag aaggtggttg tttcatcgct gtacgttaat gttgtctctt gaggtgaaac 242581 agagtatgtt ggagttaatg tcttcgtgta tggtgtatag ctcgtagttt cattgacata 242641 taaggcagaa gcgaagttgg aggttaccag tagtaaacta cacaatattt tgaaaatcat 242701 tgcgatatat attctaattt gttggttgtg ttagacaact agtgtacaag aaagagacta 242761 gatggccata acggatcttg ataattcatt ttcttacgtc ttttaaatac actccctctc 242821 catcacatac agattgattt aatgtctacc tcttctaagc catctgaaat tcttgggtct 242881 ttctctgttt acggttattt gaaacacgaa attacttaag aacacgaaat gccaattatt 242941 agcgtcgcga attgaatatc caatgcggcg ggaaaatcaa aaaacgaaaa tagaatagga 243001 aaaactgccg tagttataga atcaaacctg agcgccagtt tcattcttct agcggagaat 243061 gctttcccaa acaataaccc acagattatg tgttgaagag tctaggcttg tggaaattga 243121 aatcaaaatg tttgttccct ttaaaaaaaa tcaattaagc aaggaaagga aataaacagt 243181 gcatgctttc cttatccttg gaatactata ttatgctacc atagctggaa atgttgttat 243241 ccttgttagg cacttcattt gagacttccg ataaatcagg aatttcgtca tttaggaatg 243301 tgttcgtttc aaaattctct gcattggtta tcgttaggct ctcagaatgt aacctgatga 243361 cattgtcgac acaaaagtac tggaagcaat tcagtaagat aggaaagaca aacatgacca 243421 gaaaaacttg aaagtttggc catgaatctg accagccaag gataagatcg gcgaaccagt 243481 atgccaagtc ttctaagtag tttagtatta gaaacacgca gaacttcatc acgcccagcc 243541 caacaatgaa tataagcagc tgtttcacga aggcagagaa taagggtttt ctggggtggc 243601 tcccaacggt tttagatgga aaataattac cactttcaat gttttggaag tgtaaggatt 243661 ttagcacttt ttcaattatg tataagcaca accaaagaat gggaatccca acagtagtat 243721 ccaggagtaa gttaagaaaa taccaatcgc attgatcctc atcatcattg ccttttgcag 243781 tgattgcgaa gagtgacctt cgtcttttct tcagtatgct gatgcctaga ttcaaaaaat 243841 ggattccaag agagccgatg atttgttttc caatgtcata actccacaca atcatttttc 243901 tccttggatg ctcatagttt cttttcacca ataacacaat cacggctgtc atacccatca 243961 atgtctggac aaaaagagac acgggcccca acaactggca agtgtctttc ccattagaaa 244021 catacatatt cttttcgatt aattggcagt tctgctgaac ttgtgtgact gttgggcctc 244081 ctgctaatat gtattagaac tttttctgct tagtacattc aagtactttt gtgcagatgt 244141 tcgcatctgc aataaacttt taatctccct tccactctca tcgtctacaa acccatacac 244201 catttgtcaa gcacatgctt aatccaacaa tattcaagat ttaatattta tatatatata 244261 tatatatata catgcagagg gaacgttttc tcccctcgta ggtaaggcga ttacgtgtct 244321 aaaagaacga ttttgcaagc gcttctaaat tttgttcctc tggcgttaag catttcgtat 244381 ttttcacaat gtttagtatt atgcccgcta taaatttccc attgttgaaa caactctcgc 244441 tacccttatc tttattttct ttaaatgaaa gtatggtctc taatatcagg gttaactttt 244501 gaatgtaatc cttgaatagt atattttcaa tcggattcac gtcagctgtt acacttgaat 244561 cttttaaata aattccaacc gtttttgtga tatgaaataa atctgagatg cttagttgtt 244621 ctgcttgacc taaattttgg aatttgaaga tcgaatccca tagggatgta atagcttctt 244681 taggaagggc tttcttggac acaagcagct tatccatcgc aatacaggac gttaacgttc 244741 catgctctgc tataaaagag ataattgttg gatcactgct tattgaattg tgtatttttg 244801 aacttggaag caccgttaaa gttttgttta ataaatttgt taataacgat ctcaggttgt 244861 tataatattt agtttgctcg tgacatcttc tcataatctg aaatagggtg aagaggtcct 244921 tgatatctag ccacatggta ttttccagat ttaacagctt cctcagtaaa tctaggaatc 244981 cttgatattg tagtgggtct tgtagcaagc taccaacttg aatcaattca ctaagagata 245041 tgagcttcag tagcgcgaca gcgtcacttt tggatgcaac tgagttacat aatatcatca 245101 aagctgcggc tagggcataa ctacttgcgg aactcttaat agtttcgata cataatgatt 245161 gctctcgttt gttagagttt gttaggttgg cggagatgtt gcctgcgcac gatatgagtc 245221 ttctcattac aattagctta ttattgaagg tttttgattc taagcaaact aaggacaata 245281 ttaaattttt ttgcatgctt agcacaagct gctcctcatt ggtaaagttt atagtttcat 245341 ccttggctac aatagtttca agacatgttg acagatttaa tagcaattca caattaacgt 245401 cctcctcatc atcttcttcc tctttttcga tgtactcttg atttccttgg ccagcgaact 245461 tctgagtttc agtatttgaa tatgcttcga ctgctccatc ttccattgcc tgcaattctt 245521 tattttgcac atttgaagag atttttttga tgtactggct taagaaaaag agatcgctta 245581 tttgaacatt tgagtaattg acttttaaaa tatcgttcaa taaatctgaa cctaaaacaa 245641 ctttttcggg agatgacaaa tagctatatt gtgtggtttt caacaaaaca aataatggac 245701 ctctaatgaa gggagccaaa ttttctgtat acttgagatt tccaatgcaa aaattcctta 245761 gtagcacaac tgaccgcatc tgtaatttat ccactaagct atcctcactc ttgtcagaag 245821 aaatttcgtc cagctgaaga accccgccta tataataatt aagaagcttt ttacctccag 245881 aatccaagag aatttcccga ttatcatcat tatcaattat tgcgttagcg atacatctaa 245941 tcacttcaga actgatctca taaaacgcta ttttatcatt aattgaaatg ctcgtatcat 246001 gaaagcagat atcaagcgct tgttctaata ctcttactag gttcagtagc agcccagttt 246061 taccaacaat atctctatta cttggttctc tcaacgaaac agccaattgg tccattaccg 246121 ctaggtagct tcctaagtag acatcgttca tcggaacatc ctttattgaa gacgcattga 246181 ggatcggttg cagaccaaat aaaatttctt cgtaatccat ttagtaggac agttattttc 246241 acttgaaacc acaatctttt ggggctgaaa tatagatgag gtgatttgtt attcgcggtt 246301 agttttagtt cgcgagtgac ctgcttacgt tgtcttcagc cattttacgt tgcttggctt 246361 gccgccggcg ggtaatatga tcttattttg acatggttaa agaaaaatac ttttgactaa 246421 gtacctttat cacaagaaag tttaggaagg gattcactat ttgaagatca gacaaatgag 246481 tatacgatat tggctcaata ttttagccga gtttgcttaa acttagtggc agaactttag 246541 tcatgggaag acaagaacga tcttacgagg cccttaggac ctcggcggct aacagtaaaa 246601 ctggtaactg acggacaagg aatatcaagg tcatattttg aaaaggtctt tttgggtgac 246661 tacttgggta agaaataatt agacgaagtt tctttctgat gtgtattgaa ctagtgctcg 246721 tgcttacata cacatcgccc attattgcct atagttatcc tcactttata cgaggtctgg 246781 ccgttaacgg ttcttttaca ttgaaaaact aaatcagtca cccacgcaaa taatgaaaaa 246841 aaaaaaaaaa tcaaaagcga aaagaaacct aacgcatatt ctattcaaac gttgaatgat 246901 tgtattatta taaatcataa tcacgtaaag ccaccgaaat ttttttccag agtgaagaat 246961 ataaaaaaaa tatctttaac cagtctataa tgtcttctgg tttggtctta gaaaacacgg 247021 cacgtagaga tgcgttaatc gccatcgaaa agaagtacca aaaaatatgg gctgaagagc 247081 accaatttga aatcgatgcg ccatcaatcg aagatgagcc cattacaatg gactctgaag 247141 agttacatcg cacgtatcct aaattcatgt cgtctatggc ctatccttat atgaacggtg 247201 ttatgcacgc cggccattgt tttactctct ccaaagtcga attttctatt ggttttgaaa 247261 ggatgaacgg taaaagagct ttgtttccat tgggttttca ctgtacaggt atgccaatct 247321 tagcatgtgc cgataaacta aagagggaag ccgaactttt tggcaagaac ttcgacaatg 247381 taccagcaga agaagaagaa attaaagaag aaacgccggc tgagaaagac cacgaggatg 247441 ttaccaaatt caaagctaaa aaatctaaag ccgcagccaa gaagggccgt ggtaagtacc 247501 aattcgaaat catgttacag cttggtatcc ctagagaaga aatcattaag ttcgccgacg 247561 ccaagtactg gttgacctat ttcccacctt tgtgtgaaag tgattgtact tcacttgggg 247621 ctcgtatcga ttggagacgt tcttttgtca ccactgatgc caatccttat tacgatgcct 247681 ttattagatg gcaaatgaac aagttaaagg ctgctggtaa aatcaaattc ggtgaacgtt 247741 atactattta ctctgaaaaa gatggtcaag cttgtatgga tcacgataga caatccggtg 247801 aaggtgttac accacaagaa tatattggtg tgaaaattga agctttagag ttcgccgatg 247861 atgccgcaaa aatcattgat tcaagctcag atcttgacaa atccaaaaaa ttctactttg 247921 tcgctgccac gttgagaccg gaaactatgt atggacaaac atgttgtttt gtttctccaa 247981 caattgagta tggtatattt gacgctggtg attcttattt tatcactact gaacgtgcat 248041 tcaagaacat gtcttaccaa aagctaacac caaagagagg cttctacaag ccgatagtta 248101 ctgtcccagg taaggcattt atcggtacca agattcatgc cccacaatct gtatatccag 248161 aactaagaat attgcctatg gaaactgtca ttgctaccaa gggtactggt gtcgtcacgt 248221 gtgtaccatc taattcacca gatgactaca ttaccaccaa ggacttgttg cacaaacctg 248281 aatactacgg cattaaacct gaatggattg accatgaaat tgttccaatt atgcataccg 248341 aaaagtatgg tgatttaact gcaaaggcta ttgttgaaga aaaaaaaatt caatctccaa 248401 aggataagaa cttgttagca gaagccaaga aaattgctta caaggaagat tactacactg 248461 gtaccatgat atatggtcct tataaaggtg agaaggtcga acaagccaaa aacaaggtta 248521 aggctgatat gattgccgcc ggtgaagctt tcgtctacaa cgaaccagaa tctcaggtca 248581 tgtcacgttc tggtgatgac tgtatcgttt ctttggaaga tcaatggtac gttgattacg 248641 gtgaagaaag ttggaagaaa caagcaattg aatgtttgga agggatgcaa ttatttgctc 248701 ctgaggtaaa aaacgcattt gaaggtgttt tggattggtt gaaaaactgg gctgtttgcc 248761 gtacatacgg gttaggtacc agattgcctt gggatgaaaa atacttagtt gagtctttat 248821 cagactctac tatttatcaa tcattttata ccattgctca cttactattt aaggattatt 248881 atggtaacga aattggacca ttaggcattt cagctgatca aatgacagat gaggttttcg 248941 attacatttt ccaacatcag gatgatgtca agaacaccaa tattcctttg cctgctttac 249001 aaaagttgag aagggaattt gagtatttct acccattaga cgtctcaatt tccgggaagg 249061 atttgatccc taaccattta actttcttca tttacacaca tgttgcatta ttcccaaaga 249121 aattctggcc taaaggtatc agagctaacg gtcatttgat gttaaacaat tctaaaatgt 249181 cgaaatctac aggtaatttt atgactttag aacaaacggt tgaaaagttc ggtgctgatg 249241 cagctcgtat tgcgtttgcc gatgcgggag atactgttga agatgcaaat tttgacgaat 249301 ctaacgctaa tgctgctatt ctgagattat tcaatttgaa ggagtgggca gaagaaatta 249361 ccaaggaatc taacttgaga actggggaaa ttacagattt ctttgatatc gcgtttgaac 249421 acgaaatgaa tgctctgatt gaaaagactt atgaacagta tgcattgact aattataaga 249481 atgccttgaa atacggtctt tttgatttcc aagctgctag ggattactat cgtgaagcta 249541 gtggtgtaat gcataaagat ttaattgcac gttatattga aacacaagcc ttattgctgg 249601 ctccaattgc gcctcatttc gctgagtata tttaccgtga agttctaggt aaccaaacct 249661 ctgtacaaaa tgccaaattt ccacgtgcat ccaaaccagt agataagggt gttctggctg 249721 ctttggatta cttgagaaat ctacagagaa gcataagaga aggcgaaggg caagcactaa 249781 aaaagaagaa gggcaagtct gctgaaatcg atgcatccaa acctgttaag ttgactttat 249841 tgatctctga atcatttcca gaatggcaat cacaatgcgt ggaaatcgtc cgtaaactat 249901 tcagcgaaca gactttagac gataacaaaa aggtcagaga gcatattgag cctaaagaaa 249961 tgaagagagc tatgccattc atttctctat tgaaacaacg tttagctaat gaaaagccag 250021 aggatgtgtt tgaaagagag ttacaattca gcgaaatcga tactgtcaag gctgctgcaa 250081 ggaatgttaa gaaggcagca caagctttga aaattgctga atttagcgca atttctttcc 250141 catatggcgc caaaaccggt aaggatatct ttactggtga agaagttgaa attccacctg 250201 taacaaagat tgttgaaaat gctgttccag gtaacccagg tgttgtcttc caaaatattt 250261 aaaggagaat atttcaagat gcctcatggt gattttccga taaaagatac aagaaattct 250321 catagaaata cttataaaga tcaataaaca gcaaccagaa atcacgtcgc attgataatt 250381 tgcctcgtat atatcgtata attattgtaa ttgcacaact gtttttgttt tgtattcgtt 250441 cattttcttg taaaatgttt ccacattttc ttgtggagga tatgtatatt gattctttac 250501 ttattcgtgt tattttagct gcaaatatct gggtttgagg gctatttgac tagtctagag 250561 aaaagtagtc gtgagaaaac tatattagat agatggatga gaggagcagg tcaataagta 250621 aaagaataat aaataaatat ataaaaatat acatgtaaaa aaggtgttct aaatgaatga 250681 taaagtttat gaatgtaata tactctaagg atgtaagaaa aaaaccgttg cgtatgtata 250741 ataaacaggt ctatgatgtt aaaagatgaa aaggcctaat aaagtgaaca gaaccggaag 250801 aaactaaaaa taaataaaac ccaagtaacc acgtacaaaa agcacattga tgctaagaag 250861 atctccctgc taggaaaaca gaaatcagaa tgaaacgttt caataatcat ccctcaagtt 250921 ttttcttcat ttggagcaac gtcactactg acttttttct cccctttcct cttctctttg 250981 aaaattcatc cattttccgc tgaagcgtct cacttgtttt attgtcaact aatgtatttc 251041 tcttagcact tacatgaata agctcatttg tgttcattga tttttcctta ggtggatgaa 251101 aaggcttcaa atttttcagt agttcactag gtatattctc ccactctgaa aagaattcaa 251161 gtccagtggc agaggaaatc catggtgata gaggttcatt taaatcttca agcttcatcg 251221 caaattcgta taacgtactt ccggtgtctt cctttagctt cgggtcattg ggattgatga 251281 ataagggtct atatccagaa tagagtacat ttgtggtcat gtcactctgc tttaaatgtg 251341 aggtggatgg tactcttggt agccacgaaa aatcgcttct tttctttttt aaatgagaac 251401 ctctcacatc gctatgttct ttctttgtga ttgtcttgtt ttgctttata agtggtgcag 251461 tatgttcgtg ttccgggggt tgacgatggt acgctgcctt tttactgccc ttttttcttt 251521 tggatttcat ttgattttta gatagtaaag actggttact taagaacgta aaggaagact 251581 gaaatcttct agaagtgaga actattcctg aagaaatggc attgttcctt gataaaggcg 251641 gaataaatgg acgagctagc ttcaacatag tttatcgtcc gactttgcgt tctgacctgc 251701 tgaatatacg attagtagtt ttaaaagcac ctttataatg ttcgacagca aggagtgcta 251761 tatctagcgg gtgtttgtgt acgtatgacg gaataagtta aagaaacatc taagttattt 251821 aaatagttgc tataactacc ctttgggata aacgattctg atattgcgag cgaaaaaaag 251881 aaacggtaga cagaataggc gtttgttatc gtcgatggtg ataaaaggcg atatcgccat 251941 taaggtaaac aattattatg attatggttc ttatggttga tacgttgatt tatattaata 252001 ttaatgaatg caaacttatg ttattatata tttttaaatt ttcataccga caggaagagt 252061 caatgacctc ttgaccacac ctgttggtag cgatataatg ctgtttgagt aggcaggatt 252121 tagcatagca aatggagatc ttaacgtaat actcaaatcg ctttgttttc tcatcggact 252181 taattccgct aattcgtcta cctcttttgc caaatttctt ccttctcctt cttttctttt 252241 ttcttcttct tcttcatcat cttcatcatc ttcttcatct tcttcatctt cttcatcatc 252301 attttcttct tcttcttctt catcatcttc atcatcttca tcttcttctt cttcctcgtc 252361 ggcccttact gtaacgccat caaatatttg ggaggagcta ccatcagcct catattcagt 252421 taatagagaa tcgacaagat cttcgtagat agttgagttt gtttctgctg atttattcat 252481 ataaacaaca ttgctcttat aattttgtat acgagcaatt tgtaccctga gcataattct 252541 ttgagcaatt acggtgctta aataatgttt catcaaattg taactctctt catttgaagt 252601 ttcctcatta tttgcatcca cattttgaat ttcattgttg cattcaactc tgtccttatt 252661 atctacttcc gttgtctcca ttgcatccgc ataattagag tagctttcag atgattctct 252721 gtcataatca gatgagcaaa cgctattaac gggagataat tctctcatag aactagtatc 252781 aattacatat tcgtcttcct ctttaataga atatcgattc atggataacg gaataacttt 252841 attttctacc acaattgatg gctgtcttgc aattgcattt agggccgtcg atggttttga 252901 ccttaccaat cttgacctcg agtacatgct gctgttgcga gtgacggcat gactaacatt 252961 atccggtaca gaaatgaagg agtttttatt atttgccggt gtcatagtgg cagatgcggt 253021 taggatggat gcagcccttc taatagagga atttgttctt ctcaatgatg gagtatagct 253081 taccaaaggg ctccttgggg tgtttgatcc aactttggaa tcttcagatt ggggatggtt 253141 tgctttaaat ttcgtatcaa ctgtcaaagg tttagtcttt ttttgtggag ccaatacagg 253201 tactaaagat tttgatgaga tcgaccgttg taaattagag acgtatctct gcgatttttt 253261 ttgacgcgga gtagagttgc tgtttttgtt gactaggttc gtccctcttt tttttgactt 253321 gttgttaatg tttgctttag atttagtggt tttggaattc gtggcggagg ggaccttttg 253381 aacattatat gaaaacagtc ttcttcttaa aactagccgt aatttccgta actttttctt 253441 tatcttgatt cccaatgagg tgaaataata taagagtccg cccttacatc taatagcttt 253501 tgatcgtttt agagaacaac gactgctact tgatttactg ctgacacttg aactatacct 253561 ggaattggaa aacctcgagg attcaactcg tcttatggtc ggaactctgt ttagcttttt 253621 tttaggtttc ggtactacgc tattgtttaa ttcgatagtt tttatatcct tttccatatt 253681 taatttggtc atcggtttgg cttcttgggt cgacggcaga atggcgcttt tagatgtcga 253741 tttccttggt aataacgatg atgctgatga cggcgcgata tcgtaggaaa cattatctgc 253801 tgttgggata gtctggaatg ccgttgagat tgagccagtt atgtttccct ctggaatagc 253861 ttccattgaa tgtaactggt ttttaactac atttgagctg ctataatgaa gagagtcatt 253921 tcctgggaag tcatgagaag caaaaaagtc acttttgttc gagtctgagg aagttaatct 253981 agcggtttca ttttgattga ttacaatacg tggtgaagac gtagtattgt cagaaatgtt 254041 agcaaatgaa tagtatccat ttgatgaata accggaattt gtatttgtat tggaagtgga 254101 tgtatagtct gataatgttt gagagtttcc gtcttcatcg cgagaaactc cattttctgc 254161 tgcaaacaca tcatttaaaa gatgatgatt attcaaatgg tactcttcta gcgttcctct 254221 tggtaaactt tcgttagacg ggaatttaaa atccatttga tcgcctctaa acgacttggt 254281 ttttgtcctt attggagctc tgatgatcat tccgtatgat atatttgttg tgataataag 254341 ccaaatttat ttgagcacta ttgttaagtt aattgttctt gttttacttg ttaagccgtt 254401 aagttgtcaa ccgaattatc aagcacttaa atctatatat acaacatatt tgtacaagaa 254461 ttgatgacct gctgaaagcc cagcaatctg gttatcccag ttgaacatgt ttaaggatag 254521 gcatatcgac ttctttatct tactaaccga aatattgaat tgcctgtgta atgaatggct 254581 ggagcagcct tttttttatc ttcgccagcc atcgcttttt ttgaatattt tccacatgaa 254641 aacaatgtat gaaaaattct aaggcatcgc accaaactat atgaagggga agtgagttat 254701 tccgcaaaca gcgagtaagt ttttcgttgt attgattgcc catattatat accgtgttgt 254761 gggggcaaca gacagaagta gaagaaaaaa tttttgttga tttaactgaa gtgatgggaa 254821 ggacatttat tcatgcttcg aaaataaaac atgcggcacg caaaagaaaa catcattcca 254881 actttagaac tctgatcaaa ttattgaaca atgatgccta taagatagaa tcatcaaaac 254941 cgttgaaaaa tggtaaactt ttcaaatact ggaaaaatag gcgtagattg ttttcaaaga 255001 tagattcggc gtcgatatat atgactgatg agctgtggtt cagtgtgacg cccgaaagaa 255061 ttgcctgctt cctggcaaat tttgttaagg catgcatgcc aaatgccgaa agaatactgg 255121 atgttttctg tggtgggggc gggaacacca tacaatttgc catgcaattt ccttacgtct 255181 atggagtgga ctacagtatt gaacacatat attgtactgc gaaaaacgcc caaagctacg 255241 gtgtggacga cagaatatgg ctgaagcggg gatcctggaa aaagctagtc tctaagcaga 255301 aactttccaa aataaagtac gactgtgtat ttggatcacc cccgtggggt ggtccagaat 255361 acttaagaaa cgatgtgtat gacttagagc aacatctaaa gcctatgggg attaccaaga 255421 tgttgaaaag ttttcttaaa ctaagcccta atgtgattat gtttttgcca aggaactctg 255481 atttgaacca gctttctcga gctacgagga aagtactagg tccatttgcc aaatgtaaag 255541 tattatatgt aaaggagaat ggatatatga aaggaatatt ttgcatgtgg ggggaatgct 255601 tttttaacta cgaaccagca agtacggaga atagtcgaag ggagtcgtcc gaaaaggaag 255661 agctgagttc tgaaaacgaa gagctctcga aaagaaaaaa gcatgaatcc acaacaacga 255721 ccaaagataa tactgtagac atttacgacg taaatggtta aacacttgtt caagttgaat 255781 cgtatgatag aaaatgcaat gactatgtta tgaatgtata tatagcacat aaagaggatc 255841 gcttacgtga atttgggaat aattaaaacg ttcttttagc tgcggctgct cgtcgatagg 255901 agtgataaca aattaagaat tagaagggat gtcttttttt tctaccagca agttgccacg 255961 cgcttcagac tttagaagag gtagtagcaa tcccttcgaa tgaggttcga ttatatctct 256021 caccattcca cgatttatca cggaaatacc attcaaaaat aaataaggcg actgaatgga 256081 ttccaaggca gcactagtat cgatatttag tttattttgt ttgatatact tttctaattc 256141 atagccatga gagtgttttt ccaaatcaac agtggccaat tcgggtgaaa tctcaaattc 256201 tctttgtaat agatttttta agaaaatgga gtctgcttgt gatgatttaa tgaataatac 256261 cgctggagag gttcttatta tatctagaaa atctgttcta gggtcgaatt ttttgtgatc 256321 gcagtttttc tgcaaggcca gagaagatga ccgtggattt agtgttgttg tggtcgtcgc 256381 cgtcacgaca ttatcagttt ggaacgatct tgaagaaaat tttgatgtag ctttggatga 256441 gggttctggg atgtcgactt caacctcgct ttgaatattt gaaatttctt ctttgacttt 256501 ttggaaattt agttcatttt cattacttag aaaactgtct gctgtcttta ataagtttgg 256561 caacttgtaa acgaacttct tttcactttc ttcctcacta ttttttttgt tttcgctagg 256621 gtcagcagag ttgtagaatt ccaaggagtc attccatgta agtagtaaga agctaaatac 256681 gccaagcaaa acgagtgtta gcgatattat tctcgtactt ctcttgattg ctgtgtgctt 256741 tttcaaaact gatgaatccg ctatcatctt taactgttat tttccttttt ttaattgctc 256801 tttactgttc ttggaacaag agattatgaa gtctataaaa gaacatatat ataagtattt 256861 aagagataag cctgattcaa agacgtttgc aagtttcagt cacttggcct taacaatctt 256921 tatatattaa tccctttagt acctgcacaa ttaaggccga gacagactcg aaacaacccc 256981 aaaacttctt gatctttatt agctgatgcc aaattttttg gtaccacact gaaacgaact 257041 tcgtaaatcc attatttgtg tattttctta acgagaagtg cctaaaaact gccttttatg 257101 cgctgtcttc tgagaataga tcccgttcaa ggcaagcgcc gggcaagcgg aggcgcagtc 257161 tacagaacaa tccgcacaag gaaaaaagca cccgagatct gggaccctca cctaatcatt 257221 tatcgttatc cacgacaggg tgcggtgatt gctgtgtatt aatgagtggt ttcaaagccc 257281 tatcccgcag tcgtttggca ctctgcaggg cctcaatcat tttatccttc ctctcgagca 257341 tcttctgtaa ttcgatcact tcagtgccgt cacacccagt tagcgacatt gcagtatgac 257401 cacttttttc tagcgccatg atcttgtctt caagtttttg agtgtatttc ctatattgcc 257461 ttatttgtga ttccaaacct tggaactttg tttccaaaag ggtgccgacc tcaaagggaa 257521 gcatttctac aatttccata atctcagaat cttgcaaatc aaccacatct ttatctagta 257581 gtttttcaca attctctagt ttatatttta atactcgatt ctccgctctc attagagcca 257641 aattcggatc accatcattg ccggtggctt taatgtcttt ataagtactt tcattggaag 257701 atttggttaa gggctcgcca atgtttgaac ggttcttcaa ttcagagatc atcctacgtt 257761 gttcttccaa ttggcgtctc agtagctcaa tggtgcgatc tttatctcca tcgttattcc 257821 cgttactgat gatggatttt ttggatacat gaagtgcgac gtttttcgct cttgatgcaa 257881 acctcagcgt attcatagtt tccgctgccg catcatttct ggtgtcgact gtacatatcg 257941 ttgtcactat gctgtcaccg cttagtgccg gctgcaataa tctagtcaat ttagaatcac 258001 gatatggaat gtggttgctt gggctagtgc cgttattggt agcatttcca ctactgctgc 258061 tactgccact tgcagatggc gagggaatgt ttgagcctac tgagttcatc ttgtcggcac 258121 tgagtttgga tatcacagtc cccaaagcaa gtaaggattt gttgatgaat gaaccttcct 258181 ttctcctctc ttgttgcccc gtagcccttt ccgaacctgc taggtcacac aacgacaatg 258241 tactcgatct tgaggtgccg ttctttacgt tagtacttgt taaacgaatc agtacaatgg 258301 catgagatcg tgagcttctt gcattgtagt cagtttcgcc aattttccta cttttgtcac 258361 caactgcaat ccacctcaat aattcttcac tactttcaca tcttctttcg gtgagaccga 258421 taactttgac cccatactga gagtcatctc tgatttttaa ttctacgccc aatccattgc 258481 tgttgctctt gctcatatat aaccttgaag gagtactgat tctactaccg gattcttcta 258541 atccgctttc taacaggtcg taaatccttt cattgtaaat ttcgaggtac gatattataa 258601 cgtcgaactt tttatcgcca ttcattgatt gttccatgat attggtaaat aaatacgaca 258661 cagataaagg aattaggcct agctcttgtt catttccgct cattgtaaac gttttacctg 258721 acccggtcat accgtacgca aatatggtgg cattaaaccc catcaataac ttatcaatca 258781 ttggtttact ggttctttca taaacttcca aattagtgca atgggaagca aaaacatgat 258841 cgaacttgaa ctctccaatt tcttcatgca ctattgtttt gtcattagta ataaaccagg 258901 ggtctctaac aaatgtattg ctaccgtgat gtgagttgga tcttggttga gagtacctgg 258961 gcgattttag ccccacatgg tcacgggaag ttccaacgct ccgtggtttc ggccggatgg 259021 tcacagtgat tgacccagta tatgtatcgt tttttctcga gttgttgtta atactgtcgc 259081 tccgcctgat ccttatccta cctgggtgaa ggaagggatc ggatttggct gatacggatc 259141 ttagtgggga gttacttcta gtggaagatg cagaaatcga ctgagaaccc gaattagagg 259201 tgctccgtat ggagtttctt gtcagattag aaaacgatga agttgatcgt acagagggcg 259261 attgtgggat attacttgaa ccagaactag acctcgttga tggcctcctt aagcttgggc 259321 tcattttttg aatcatcaat ggtggtatta tggtaagaat tttatcaagt gttctatgtt 259381 tgccttgatt tcaaatgttt ctagagcgca gcctgtgaat ctctgcagcc tatttctttt 259441 tatttttcgc ttctgcttac attgctttat tatcaattgt tccgctattg gaaaaggata 259501 aacaaggaaa ttctcgagcc gcatcatcgg gctacccgca tataatgaca ttatgggcag 259561 cagcatagaa caatggattc taaaactgag gacaagatgg tttgtcttgt tttttttttt 259621 taaatatact atagtttttt ttattgttat ctacttataa aagctctcta gatggcagaa 259681 aaggataggg cggagaagta agaaaagttt agctcaaatt gctttggcca aaccaaccgc 259741 attgttgccc aaatcgtaaa tagaatagta tttacgcaag aaggcatcac caacgatggc 259801 cagtgggcca acaggttctg ggaaatccat tggtgtaatt gcagagatac aggagcctga 259861 aacttcaagc gtgtaatcgt atggcccaat agtgaagttg tagccattga agttgaaaat 259921 tagatcaggt agattgtctc tggtgttaca gtctagagta tattgaccgg tccaaccctt 259981 cttggcccca atttcagcat taatcatttc agctaatcct gatggcaagg taatcaaaga 260041 agtaccagta tcgatggcgg caccatggct ctccaattcg gcgtactcgt cgcctaaacc 260101 gataccttca aacttgactt cccagtaagc cttacgacga acaggtaacc aagtgatatc 260161 gcccttgaac ttagactcgt caataccacc aaaggtggct tcaccgccat tttcagtatc 260221 ctttgaagtg tctcccaaat aaaaggcaaa tctcttttcg tccaacaaat cttgttgaat 260281 ggcgttgtaa aatggaggga ccaccttatc aacagaaatg gtatcgtaac ccaaacccaa 260341 aataccatcg aacttgccaa atgcaaatgt taagcccggc tcgctggtag cctcagcgaa 260401 gtcttgtttt ggaatggtca aatccccgat ggacaaagtg tcttgagaaa tgtaaccttc 260461 caaagaacca gtaccatatt gaatggcaaa ttcagtacca ttagctttgt agcttgatga 260521 agcttcatga tcgtatttag aatgtaggaa acaagccaag gaaccacatt cgttacttgg 260581 aacccaaagg tttgaagaac cagtatccaa aataaccttg aagttttgag gtggagtacc 260641 caaagtaatg tcagtgtaat attgtgcgtt caagtaattt gtcaatggaa catcgtgacc 260701 accttcagtg aagaaaggat gctccctaga aaaaacaact tcggggttag ctttctcaaa 260761 ttgagtcaag tacttttggc ctaaatgagc taaatgttgc tcgaaagtga cttctttcat 260821 ctcatcggac aactcgtgtt tataaatttt agccttgtgg acttttgcag caacttggtt 260881 ggcgctgacc aacaacaagg ccaatggcaa taatgctttc aagctgaaca tgttagtttt 260941 ggtttttgtt tgaattttat ttggattaaa tactaggtca ctaggctttt tttttttctt 261001 ttcttataga attctaatag aaaaaacttt ttatgaatac agtagggtga gatatacttt 261061 ttgttattct tcccttacgt ggtaggcttc tcaaataaaa atagaaaaga ccactaaaat 261121 ttgattataa aggcttcgct caaaaaagaa gaaggtggaa tgaataaata gcagcgaatt 261181 acccaaactt ctttactctg ttcccttaac cagttgataa gaggttacga agtacggaag 261241 tatggctttt tatataaatc ctaaaaaggg ccgcctccgc cccttaatcc atcgacaccc 261301 gcaaatgaaa tatagtaccc ggaaggcata agacgggtta cagcctctcc atagattcaa 261361 taaccgcttt tggttataga aataatcaga cctcagcaaa tacaattgag gagctcaaga 261421 tattgaaaac ggattaacaa actttttaaa attatttatg agcttgttgt accacatcaa 261481 gcaggattat gtttttttca gaacttcttt ttctgattca aaaattcatt aagcataact 261541 aaaactgaaa atcaaaactt attaatatac aaaaatctat atatttcaaa atgtaaatcg 261601 tatcaaaacg tcactctata tgtaataaaa acccaaaaag ttatgaatag atgaattctg 261661 agtattggta tctaccatct tctctcttaa aaaggggcag cattttctat gggtatttgt 261721 ccttggttac gaaaattgca aattctcggg gccttttgag gtttggtcca attttgccct 261781 tttaaccttc ttactaggat caatttgtga ttgcgataaa cttaccgaat gtattctctt 261841 caaaatgttc cccgtattcg cattaatcgg tgactctacc aagtcgttta gtaccgaatt 261901 attgccgtta ttatttgtat cgctaactgg cggcttctta gccgacattg atgaagaaga 261961 agccgagggt tgatttgcac gttgagctgc catcatctgg gttaactttt tcaccaaatc 262021 tttttcttcg gctgtttgct taagtactac tctttgttct tgtaacatac ctaatccctc 262081 gttaaacaga cctgtagtat cgttaatttc cactttaaag ccaatgacaa atttattgtt 262141 tttatcccaa atgatcttga tttcatctcc gtcttgtaaa aggaatttcg taccctgtat 262201 catgcggtta ttatttaaat agctcacgtt agttccggtg tggcaatacc aaatatcatc 262261 taaaccttgt gccggagatt catacatgct tttgcctaca gcatgcctct ttttgaaaat 262321 gaagcaatga actcgagaca acctattgtc ttcaatttta caattgcaat cctcggatct 262381 accaatgaaa aatggattca caccttgctg aatctccagg ctttcttgaa taatgctgtc 262441 aggcaatggt tttaaagtta aaaacctacc attacccttt ttctttgagc tcttgacatt 262501 ctcagtatta ttggaatgta aaagtttttg ttctctagtt tctgcttcaa tgcttttggg 262561 ctgtgtatat cgaatagggg cgtgtgcggg tattttaaat ccttgaattt ttccatcttg 262621 gtcttcctga tcctgttctt gaagttgttg ctccatttgt aatttccttt gcgctttgac 262681 aaattcgtat tgagcatcgt ccatattttc taataatttc tgctgcgaca acgattgtga 262741 taaggatatt tgtgaaaaat caccatatga ttgtgagccc aatggactca tcttgatcca 262801 gggatgattc aaggcttttg cagctgtcga cctattattt ggatccacct gtaacaatga 262861 atctatgaaa tctcttgctt cttcagatat ccggaaatct ttgaggggcc cttcatgata 262921 tgagcctctt ccaatctgtt tatataattg gtcctgtgtg ctaccactaa aaggtaagtg 262981 gcccgttagg ataacataca caagacatcc cattgaccac atatccacta acgaagagta 263041 ctcattcctt tcttcgtatt catcaggaga tacggatgta tctttacctc tgatgacttc 263101 aggtgccaca tatgccaaag tgccacagaa ggttttcata aaagacccat ttccttgtac 263161 ttttgccaga ccaaagtcgg ttatctttac caatacagga tcgtcttgtt caataagaat 263221 attatcgggc tttaggtcac gatggctgat gcccatagag tgaatgtatt ttattgctgt 263281 gagtatctgc ctggatatct ccctcccagc atcttctcca accgcaccat gagcagcaac 263341 aaaatccatt aagtcaccac cagaaacgaa ctccatcacc atataataac tctcagtatc 263401 ttcataaaat cctttcaatc gtactatcct tggatgattg agcttttgca atacttctaa 263461 ctctcttgtc acaccatcca tattgcctat tactttgcgt ttacttataa tcttcaccgc 263521 gaatgttttc ccagtagttc tttcaatggc tttctttact gtggcaaatg caccctggcc 263581 caccacttcg tcaataatcg aaaaatcctt aaaaatacca gtcttgttgg ccaccattga 263641 tgatgcagta gatgatgtaa gaccaggaga agctatttta gaggtatttt tcaggttaga 263701 tcttatgcga tcaactttgt tctgctcgag gcactgctta aatttgtcgt ttatgaaaat 263761 gaccagagat aaaatatctg attccacgcc tacaccaacg gttatttcat caccttgaga 263821 cagtaactga ttgctgttct tctcgacttt ttgcccattt aaccaggtcc cattagtgga 263881 aatgtcattc aataaaaggt taccgtcttc tcctagtagt atttggaaat gcttatttga 263941 cagtcttgaa atgtttccta aatgatagtc acaggctggg tttctaccaa atgtccaaac 264001 tttctttatg gatcgttttt ccttaagcac ttgtgaaata tcagctgaca aatctcggat 264061 gggaatttga cccgtggtac aaatgaccct gcacacaatg ttttcgccga tctgttcttg 264121 agaaaacttc tcaatcaaaa acctttgagt agcctgcgtg gattgctgtg tgggttgtgt 264181 aatattttcc atttttagtt gatgttgtgt aacactatct tttctcacta ttctctcttt 264241 taaagcttaa gaaaatcgaa tgcatataca aaattagttt gtcttccaat aatctctacc 264301 gtccttttct gctttcttac cttttcttga tcagagattt caaaatggta actttggtac 264361 cctttatctt ctcaacctgt acctttattc tataaatgtt ttcatttcca agtctaccca 264421 cggtgatgat ttttctgcca attttacgcg tcactcccgt tgccgtatca acgcgtccac 264481 accacctcac cctcgaaatg aaaataaata tgttaataga tgcacgtttc attgacatct 264541 gtgacaaaca ctttccggct taattaaaag gaagcaggct attaatgcac caaccaaaca 264601 aatgatggtt cacctcacgc tgaaatctca tctaataaag gaagaattac tttggcatgc 264661 tttatctccg tcctatagtt gccgatacca cggtagataa tacagtatca ttctaaaagt 264721 accatttagg taggtgctga gcgaaccaat aagtaagttt ttgttttttc tcagtgtttg 264781 ctttgaattt acattgaaat acgttgtttt ggacgtacta caatagccgc cataatagat 264841 tttcgggtaa cttttacact cttccctctc tttcacgtga gtaagcacag aataaaatcc 264901 taacggatgt gatagaacaa aagggatatc aatgacaaga gagaggtact ttatgttagt 264961 cgcctgtgca gaaagaacag tccataaaca acaatccgta aagaacaata taaatattta 265021 gaaaaagatg ttgccagaaa agagactatt gactccagac gatatgaaac tatgggaaga 265081 atccccaaca agagctcatt tcactaaatt tattatagat ttggctgaat ctgtcaaagg 265141 acatgagaat tcccagtaca aagaaccaat atcggagtca ataaacagta tgatgaactt 265201 gctttcgcaa ataaaagata tcactcagaa gcacccagta ataaaggatg cagatagctc 265261 gagatttggt aaggttgagt ttagggactt ttatgacgaa gtttcacgga attccaggaa 265321 gatcttacgt tccgaatttc cctctctcac agatgagcag ttggaacaat tatcgattta 265381 tctagatgaa tcatggggaa ataaaagaag aattgattat ggttcaggtc atgaattaaa 265441 tttcatgtgt ttactttatg gactctatag ttatggaata ttcaatcttt caaacgattc 265501 aactaacctc gtgctgaaag tttttataga ataccttaaa ataatgagga tactagaaac 265561 taaatattgg cttgagcctg cgggctctca tggtgtttgg ggattagatg attatcattt 265621 ccttccattt ctatttggtg ccttccaatt aaccacccac aagcacttaa agccgatatc 265681 aattcacaat aatgagctcg tagaaatgtt cgctcatcgg tacttatatt ttggttgtat 265741 cgcttttatt aataaggtca agtcatccgc ctccttgaga tggcattctc ctatgctaga 265801 tgacatcagc ggtgtaaaga cttggtcaaa agttgctgaa gggatgataa aaatgtataa 265861 agccgaagtc cttagtaaat tgcccatcat gcaacatttt tactttagcg agtttttgcc 265921 ttgtccggat ggtgtatctc caccaagagg ccacatacat gatgggactg ataaggatga 265981 tgagtgcaat tttgaaggac atgttcatac tacttgggga gactgctgtg gtataaagtt 266041 accgagcgct attgcggcta ctgagatgaa taaaaaacat cataaaccaa taccttttga 266101 ttaggaaaag tccatttata gatgctatct cattgtatat acacgtatac agggtacgta 266161 ctttttccat ctactcccac taaaatcttt tggcgcttaa gttggggttc cacgctagcc 266221 ccggttctga ctcttttgta gccgtctcat cctgtttcca aatctttatg cttttgtctg 266281 cttctccagt gattaatctt aaacctgttt tatcgaaagt gctacaaaga acactccgtt 266341 caccttccag agagcctacc atttctctcg tggccaacga ttggtatttg tgaccagact 266401 tataatcata aaaggaaagc acaccattgt caccgccagc gaataataca tcatcttgat 266461 taatgcttaa agtattgatt atgcctgtct tttcagactc aaaattggtg agtaaagacc 266521 cctctgctaa tccccatgat ctgatgtcat cagtacacgc agaagccacc gaaaactcct 266581 taggatgcaa cgctgtagct ctcacagacc tcttatgatg tgttagaact ttcattgttt 266641 tcccagcaac tacatcccat aaccttaccg tagcatcagt cgatgaactc accacttgag 266701 ggtctactgg agtacactgt acttgattga ttggaccctt atgcccaact agtgtaataa 266761 caggtattct ggttctcata tcccagagtt tgataacgct atctcggcct gcggtagcta 266821 tgagatccag cgttggatgt atgctcaccg tacgaacccc cgataaatgt ccatagtaat 266881 ctctaataat ttggtttttc tctaggtccc agcatttgac cgtcttatct tcactaacag 266941 aaaataaata aggatgtcga tctgacacag caacgtctct cactgtcatt acatgccctg 267001 ctaaggtagt ttttaatttt cctgttgcaa gatcccaaac tttcattgtc gtatcattac 267061 ttccggtgat gaaccattcg ttgtcaacag gatcgattgc aacgcatcgt acccatccaa 267121 gatggccatt gataacgcgt gaaagtttcc agggtgcatg ccattccggc ctttgtgaca 267181 gaagtttttc gtatcgatta actataagtt cttcagcaac ctctggttgg aaaattttat 267241 tcacaaaagc agatgcatgc gtatcgtgat ctttcttgct aatcactgct tgtgatgctt 267301 ctgaaaaatc tgtaggaaca tgctgcagag taactttctt gccttcacca ctaaaagaag 267361 aactttcctt cctataagta tcatatcgca ttagcaatga tttctgacct tccatttcgc 267421 tttgtaggtg gggcggcaga gtggccatat atgaaaattg gttattccag cgtattctgg 267481 aataaaattt gtctacatct cctaaatttt cgactttgtg atcatttccg tccattctca 267541 ctaatctcca tgtaacacag tgtctgcatc ctcggaaatg gttttaagat gcaatgaagt 267601 gggtaataat tactgttagc ttcacatctt gaataatctt ttattgccaa aattgtagct 267661 tttccgtatt agatgatgaa gaattttgag cacccttact taataaaaga gttgttgaac 267721 tcgaaatagg aatacgagat gaggagtaat tctctgaaag tagatagctc ctcttgtcac 267781 attgaatgct actttattgt gactataggt gatttaagcg aacgaatgtt cttaggtcat 267841 cgtggatttg tgtggtgatt ttcggcttat cttaacaatg ttgaccgcgt ggaccctccc 267901 aatcttgaca acagaacact tatcaataac ggtatacaat aaatatcttg tatgaattaa 267961 ataaagtaac gttttttccc tcatatcatt ccgaatcatt acgaaaattc caatacctgt 268021 attttgaagt caacaagagt ttcgttatcc gaatactatt ttttgtatca ataaattttg 268081 tttcgttttt cattaataac tagtcactgt gtagtggaag caagttctcc ttatccgttg 268141 ccaagagaca ataaaagacc cacatatagg tgaatatact gctcaccatg gttaatcctg 268201 ttggatcctc gaaattggaa caaaacaata taaaaagcat tataggatca tcgtacaatc 268261 gactatacag ccaatttact tctgatgagt tgacagaagt gggaaactac aagattttaa 268321 aacaaatagg tgaaggaagt tttggaaaag tatatttagc gctccataga ccaacacatc 268381 gtaaagtctg cctaaagacg agtgataaga atgatcccaa tatcgttaga gaggtatttt 268441 accatagaca gttcgatttt ccttatatta caaagcttta tgaagtgata gtgacagaat 268501 caaaagtgtg gatggcatta gaatattgcc cagggaagga attatatgac cacttacttt 268561 ctctgcgtag aatatcgtta ttggaatgcg gagagttgtt tgcacaaatt tcaggtgctg 268621 tttactatgc acactcaatg cattgtgttc atagagattt gaagttagag aatattttat 268681 tagacaaaaa tggaaatgca aaattgacgg attttggttt tacgagagaa tgtatgacaa 268741 agacgacatt agaaacggtt tgcggtacca cagtttatat ggcacctgaa ttgatagaaa 268801 gaaggactta tgatggattc aagattgata tatggtcatt gggagtgata ctatacacat 268861 taattacggg atatttgcca tttgatgatg acgatgaggc taaaacgaaa tggaaaatcg 268921 tcaatgaaga accgaaatac gatgctaaag ttattccgga cgatgctagg gatttgatct 268981 cacgattatt ggctaaaaat ccgggagagc gcccatcgtt gtcacaagtt ttacgccacc 269041 cttttttaca gccttacggt tcagtggttt tagatcagac tcagaaaatt ttgtgcagac 269101 agcgcagtgg agggactcag tttaaaagta aattagaaag gcgattgctg aagcgtctta 269161 aacaatcagg ggttgatacg caagcaataa aacaatcaat tttgaaaaaa aagtgcgatt 269221 cactctcggg tctatggtta ttgttgttag cccaagggaa aaagcaagaa aattgcaaat 269281 atccaaaaag aagcaggtcc gttttatcag tcaaaaaagt tattgaaagt gctacgcata 269341 acgacactaa tggcattagc gaagatgttt tgaaaccctc acttgaactt tctagagctg 269401 cttcattgag taaaatgctc aataaaggct cagattttgt aacatcgatg actccggtta 269461 gcagaaagaa gtctaaagat tcagcaaaag ttctgaatcc tactctctct aaaatatcct 269521 cacaaagggc ttatagtcac tctattgcag gttctcctcg caagtccaat aatttcttac 269581 aaaaagtttc tagttttttc aagtcaaaaa aaagctctaa cagcaatagc aacaatagta 269641 ttcacacaaa tgttagtgaa agcttgattg caagcaatag aggagcccca tcttcagggt 269701 cgtttctcaa aaaaaacagt ggttctattc agaaatcaag aactgacact gttgcaaatc 269761 cttcaaggac ggagtctata ggatcgttaa acgaaaatgt tgccggtgcc attgtgccac 269821 ggagtgctaa taatactaca ttagaaaata agaaaacttc tgggaatgaa ataggcttaa 269881 aagtagctcc agaactatta ttaaatgaac atatccgaat agaggaacct cgcctcaagc 269941 gcttcaaatc gtccatatca agtgaaatat ctcaaacttc tactggtaat tatgatagcg 270001 aatctgcgga aaattctagg tctatatctt ttgatggaaa agtttccccg ccaccgatac 270061 gaaatcggcc attgtcagag atatcgcaaa tttctaatga cacttatata tcagagtact 270121 ccactgatgg taataattcg tcattcaaaa tttcagacac tatcaagccg agctatatac 270181 gaaaaggctc tgaaactacc tcgcagtatt cagcttcatc cgaaaaaatg acaaatggct 270241 acggtagaaa atttgtcagg agggatttaa gcattgtatc gactgcgtcg agcacctctg 270301 aaagaagttc aagaacagat tccttttacg atatcactac agctacacca gttgtgacca 270361 ctgataatag gcgcaataaa aacaataatc tgaaagagtc tgttttgccc agatttggga 270421 ctcaaaggcc atggactggc aaaaggacgt ataccacgtc ccgccatggc aagaatgcta 270481 ggcgttcgtc taaaagaggt ctgttcaaaa taacttcttc aaatacagac tctattattc 270541 aagaagtaag ctcatcagaa gaagaagatc ataatgttat ctatagcaag ggaaagggtc 270601 ttccaacacc agttttgcaa actaaaggat taatagaaaa tgggttgaac gaacgcgatg 270661 aagaaggaga tgacgagtat gcaattcaca ctgacggaga attttctatc aaaccgcagt 270721 tttccgatga cgttatcgac aaacagaatc atttgcccag cgtgaaggct gtggcaacta 270781 aacgttcgtt gagcgaagga agtaattggt ctagtagcta tttggattcg gacaataatc 270841 ggcgaagggt atcttcattg ctagtagagg atggggggaa tcctacagcg taggtaccgg 270901 ataacagagt aactggtaaa aacggcaaaa aatactgtaa ggaagttgtc tatatatgta 270961 catatggata ttgcggtata ataaaaaagc tttaaaatta taaagaaacc cgacttttat 271021 cacatataat tatattataa aaaaataatg gcatctgtat gaactcgcga ttaagctcac 271081 ttttttctaa tgatcgaagt tttgtccggt tatccaactg tggcaagaac atcgcgaggc 271141 ggagctaaac acagaatttt tgtagcgcga tgagaaacat aacgcctctt tagataaatt 271201 atcatcacct tttttacact aaataatgaa gtagcatgct cagaagtgcg aatgaatttt 271261 tgttcttttg gttctagaag aacggagata ggaaacctat gatgtaagta tgaatgacat 271321 taaacaatta ctttggaatg gtgagcttaa tgtgctggta tcgatcgatc cttcattttt 271381 gatgaaagga agtccaagag aaattgcggt gctacgaata agggtaccaa gggaaacata 271441 tttagtcaat tatatgcccc tcatttggaa caagattaaa agctttcttt cttttgaccc 271501 attgaccgac agtgagaagt atttctggtt tgagcataat aagacgccta ttccgtggaa 271561 ttacccagta ggtgttttgt ttgactgcct agccggaaaa agcgctactt ttaccacctc 271621 ttttgagaac caggtaaagg atgttctcac ttttttgaga attcacttgg ttatgggcga 271681 ttcgttgcca ccaactatca ttcccatcgc atctagcaaa acgcaagcgg aaaagttttg 271741 gtttcaccaa tggaaacaag tttgcttcat actgaatggt tcctcaaaag ctattatgtc 271801 tttatcggtc aacgaagctc gaaaattttg gggcagtgtt attacgagaa atttccaaga 271861 tttcattgaa atatctaaca agataagttc atcaagaccg cgacatatac cgctcatcat 271921 tcaaacctca aggacatcag gaacttttcg aatatcacaa ccaactatca gtatgactgg 271981 agtcaatcct acgttgaagg atattgaagg cgatattctg gacgtaaagg aaggaatcaa 272041 tggtaatgat gtcatggtta tttgtcaagg aattgaaatt ccttggcata tgctcctgta 272101 tgatttgtat tctaaattgc gaagttttga tggctttttg tacataactc ttgttcctat 272161 aaaaggcggc gataaagctt cctctgagct ctaagagctg ttatatacgc atttaaaagt 272221 gtcattcaaa tatcgcagaa aataacttgg acgttgaaaa tagggccaca tttatacggc 272281 tgcaagaaaa cttttactct ctttctacca agtttgttac tgcaattaaa taatctttat 272341 catgggatag cgaaactaaa aactcatgag tggaaaagag agaatcgtag tttttcgaga 272401 gctgttgata ctttggatac ttttttccaa acatcttatc aaactctaac tgaggtacac 272461 ctgtatcggt ttgtgtttta tatagcattc cagcgtacag tacttgggca ggaggtagat 272521 catgctttga aacacagcaa cacaacgctt tcaatgagca ttccttcaaa gcccaaactc 272581 ccgctatata ttcatgcaat cgtggagtta agcagttttc ttcgatgaga agattactga 272641 aatgaaatct ttccttttca tgcatgaact tccgtgttat tttattcaag gtagaacggc 272701 cacatgggtc gaatggggaa tatttctcta gtatatgtgc aaatcttggc aagtatacaa 272761 tgtcaactcc cactcctgct atcttacgtc caatattcct cgatgcaaaa ctcatcactg 272821 gaggcattca aagctagcac ttatgaaata aacgttcatt agaaagcaat actcctgata 272881 agaaaatagt gcttagcttc tattcagcct tcttaaagaa ctagcttttc tatcaaaagt 272941 cagatctctt atgaccgctt gaacctgtgg aatgtatata agcagttttg atgttaagat 273001 ttttttttca atagaatttc ttccttcgga aataatcccg attaagaaat tattcttgac 273061 gcaatattca gctatatgtt gatcgggctt aaccgcataa gtttcgttac ccttttttac 273121 cccaattttt aatttcggcg gttattttca gcccttttag agtcaagata tataagaatg 273181 cttctctaag aagtgagact aacaatgaaa cccgtttcag acaatctgga agtcttagaa 273241 cgcataacac agaaatgtca acaacattag cagcaccagc gaaactaaag agtttgctcc 273301 tgaatctaca tactcactgt attgggctac acgttaacga tgtcacacct aaagtatatt 273361 tcaagttatt gatacggcat cttctacaga tatctagatc aaacgctgct catcctaagc 273421 taagaagaag ggcccagatt ttattggtat cgcttttcct atctggtgtc acactttttt 273481 ctggtgtaac atatagtact ttcaaaatta ttctaaaatg ttataaattt tacaagtttc 273541 catggaagag aaggaatagg agacctttaa taagaagaac aagatctcaa atgcaattag 273601 acagtggtgc aagaataatg tatattcctg aagtggaatt agtcgaccgc cagagtcccg 273661 atgacaacaa atttatgaat gctacagata aaaaaaaaag gaaaaggata tttattccac 273721 caaaggataa cgatgtatat gaacacgata agtttctttt taaaaatgta gaactggaaa 273781 gagccaagaa ttcgcagtta ttctactcaa aatttttaaa ccaaatgaac gtcttgtcta 273841 aaattttaat tccaacagtt tttgacaaaa actttcttct tttaactgct caaatttttt 273901 tcctggtgat gagaacttgg ctctctttgt ttgtagccaa gctggatgga caaatagtca 273961 aaaatataat tgctggtaga ggaagaagct ttctgtggga cttagggtgt tggtttttaa 274021 ttgctgtccc tgcttcttat actaatagtg ctattaagct acttcaaagg aagttgagtt 274081 taaactttag ggtaaatttg acacgttaca tccatgacat gtatttggat aaaagactaa 274141 cattttacaa attaattttt gatgcaaagg cgtccaattc ggtaatcaag aatatcgaca 274201 actccattac taatgatgtt gcaaaatttt gcgatgcgac atgctccgtt tttgcaaaca 274261 ttgcaaagcc agttattgat ttaatattct tttcggttta tttacgtgat aatttgggaa 274321 ctgtgggagt agcaggtata tttgttaatt atttcattac tgggtttatt ttgaggaaat 274381 acacgccacc attaggtaaa ttggcaggcg agagatctgc ttcagacggc gattactaca 274441 attatcatct aaacatgata aataatagcg aagagatcgc attttaccaa ggaacagcag 274501 tggaaaggac gaaagttaaa gagttgtatg atgtgctgat ggaaaaaatg ctgctggttg 274561 ataaagtcaa gtttggttac aatatgttgg aagactatgt tttaaaatat acatggtccg 274621 gtttgggtta tgtttttgcc tcaatcccta tcgttatgtc taccttagcg acaggcatca 274681 attcagagga aaaaaatatg aaggaattta tagtcaacaa aaggttgatg ttgtcgcttg 274741 cagatgcagg ctcgagattg atgcattcga taaaggacat ctcacaattg accggctaca 274801 ctaataggat atttactctg ctttccgtct tacacagggt tcactctctg aactttaatt 274861 acggcgctgt tccttcaatc ctgtcaatac gtacagaaga cgcttccaga aattccaact 274921 tattacccac cacggataat tcgcaagatg ctattcgtgg tactattcaa cgcaatttta 274981 acggtattcg gttagaaaat atagacgtaa tcattccatc agtaagggcg agcgaaggca 275041 taaagctgat taacaagctt acatttcaaa ttcctttgca tattgaccca ataacttcaa 275101 agtccaattc tatacaagac ttatcgaagg caaatgatat aaagttacca tttttgcagg 275161 gttctggctc cagcctgtta atattagggc caaatggttg cggtaaaagt tcaattcaac 275221 gcattatagc tgaaatatgg ccagtgtata acaaaaatgg attattgtcg attccttcag 275281 aaaataatat tttttttatt cctcagaaac catattttag tagaggtgga actttaagag 275341 accaaattat ataccccatg tcctcggatg aattctttga tagggggttt agagataagg 275401 agctagtaca gatattagtc gaagtgaaac tagattatct tttaaaaaga ggcgttggct 275461 taacttacct agatgccatt gccgattgga aggacttatt aagtggtggt gaaaagcaaa 275521 gagtaaattt tgctagaatc atgtttcata aaccactata cgtagtatta gatgaggcta 275581 caaacgcaat tagtgttgac atggaagact atctgttcaa tcttttaaaa cgatacagat 275641 tcaatttcat ttccatatca caaagaccca cattaatcaa atatcatgaa atgttactag 275701 agatcggtga aaatcgagat ggcaaatggc aattacaggc agttggtacc gatgaagcaa 275761 tcacgtcgat tgacaacgag attgaggaat tggagagaaa actagaaaga gtaaaaggtt 275821 gggaagatga gaggacgaag ctacgggaaa agcttgaaat tatttgaaaa caccctagaa 275881 agggagagat tttatttagc gaatataatt tatatattat ttccgtaact gaatttgtac 275941 ttttgaatgt ttaactgata tctagagata tcgacatggg aatgccctct caaactagaa 276001 aagggcagag aacgaaaaga aaatgaaaca atttgttacc tactatacag ttgttggtct 276061 tgccaacaca aatatgaaca tatatatata tatctcactt gatgaatcca cgtatcaagg 276121 acaacctttt catggaaaca tatactgtaa aacaaaaaac tctatttgaa gtccttatgt 276181 gtccactttt cagtgatttt ctgcttatac tttctacctt tcctaacggg cactcttgtt 276241 tcgaccttac cagaactttg tagttttctc acagtatcat atagcagatt tccttcaggt 276301 ttcagttttc tcaatgagtc agataattcg tcagaaaatt taatctccaa tctttcatca 276361 atcacagagt atttcgtccc taacttgtgt ttcttatttt tcttgctttt tttaaccttg 276421 ttgctatctg actctatggc tgaaagtatc tcagtctctt cagaattgat aacttcttct 276481 aaatctttaa cacgttgtct caattctttc aactcttgtt gcaattttac tttctcttca 276541 tgtctctttg ccttgtttct ttgatatttt gttttctttt tattcttcac aggcttattt 276601 attgatagtt ttatttcctt atcagatcca ctacattgcg tactttcatt ttcattttca 276661 ttttcttctt cttcttcttc ttcttcttcg tttgatgaag actcttcctc ttcattgtca 276721 tctaaagttt ccattaaatg tctaattctt tctttgtact tttccaaggc gattctttca 276781 tcttctcttg ccttttcctc tttatactct ttgtttatca attctgacca agctttattg 276841 ttgggattgt aggatttacc agcatgtgga atttctgtga attcttttac tgcaattggc 276901 tctatatcta aagtacttgg tctgactgaa gcagtagacc aacttgtcgt ggattttttc 276961 aatagttctt caggtatctg gtcctttttt tccacatcaa gtttgatacc ggaaggtaat 277021 ttgaccttct gtttctttga attggattct tcaccccata agtcgccagc cgttgtttta 277081 actagaccgt ctttggcaac tctattcttg atcttcgatt cgccgtgtac tctgccagcc 277141 aaagccatta atttctttaa ttcgtgttta gaaacacctt gaatcttatt aggatttcca 277201 ctactattct tatggtgatt tagtgctgca atttttgaat tcgttttaac ggcgtctaaa 277261 atctctttac tttttagaac cttcttaatt tgtttccttt taattaattt atttttcaat 277321 atctcatcac cctcaacatc aacatgaaaa agagcatcat tttgcaaaga ggttatatca 277381 ctggtaccat gcgtaatttc atgatcaatt ttcttttcca tatattgttc tacgtcagat 277441 aaatcgatat tttttctcca tgctttctta ccctttcttg aagactgttt gtattgagat 277501 ggtttcttgg ttagattagt tggagccatt tttaaataaa tgattcatta acgtgaggat 277561 ggtatggatc acaagaaagc cgaactaata gcataagttg taatgtaagg accccatcgc 277621 atttttattg ctcttttctt ttttagaagt gaaaaagctc gggcacggaa aattttttga 277681 tggaattata gaatttcgtc aaatatgact gtattctctc agagcacacc tgttaggtaa 277741 tacgcaatat tatgataata ttactttagt acttggcgtt agcctcttgt gtttcattgt 277801 tatggagtga taaaacaggc ctatggttcg ataagcgtac agattttggg atataccata 277861 aactttgtat agaaagtgtt gtataagtgc atatactcca tcgattatgt ggttctacaa 277921 aattgacata agaaaattag agagttataa aaaagacaaa agtgaggata tcaacagaga 277981 agataaaata tagtaatagg ttgtaaataa taacaaaact tgcatgaaaa cttggtaaac 278041 ttcaaatttt aaccttcgta tgatgattaa aaaggatatg acatcatgag aaaaaaatga 278101 gcgatctgtc tatcaataat taaaggaaga agtagaaata gataaaggtt ttttctgctt 278161 catctttaac agcaatatag catattcttg tggttcgaaa gaataaattc tagtcattat 278221 agtgaaaaga gaacaaaaca atataagatt taggggatgg taaaaatgat ttcttagttc 278281 ctctaatgat ttcatatcct ttcctgtcac atgaagagaa aaaggaagga aaaagaagaa 278341 aagatagata atatattagt gcaacggtaa caagttgtta ctttatcgtt ctccttacaa 278401 aacaatttcc ttttcttcgt cccacaactc tctttggaat ctccaatgaa tggatgaaag 278461 atcctccttc ctgtcttctt tgtcacccac caaagtacca cttggagcat tcttcgttga 278521 taaatttaga gcagaggcga gttttaagaa agtgtcatcc ttttcaggta caagggcgcc 278581 ttcttcgggc gtgacagagt agtcaaaatc tttgaaccat cttctttgcc agctaatgcc 278641 tttagcttct tcctcttttc tcaattctct ttgcgtttct tccaattcag ttttcgtttt 278701 ggcaattaag ttaaaatcgc ctaatttgat ggcaccagcc acgtcgtacc aggcttttct 278761 actttccagt gggtgttgct cctccaaagg cttgacattc agatgttcag cagggattct 278821 agcagcatcg taaaataatc gtgattcttc tttcttattt gccttgatta ttttagaaga 278881 gccagaccat tggcctgata ttgtgtataa tgccttttcc ttgtccttgc tatctttaga 278941 gtctttgtaa attcttgcct tgaatgaatt ctttttacca gaaaagtagc ctctacctga 279001 aaattcaata acacaaagta gacctgtcga agattggata tatgattttc cttccaattc 279061 aacaaaggga gaagcgacaa gaataccttc aatatgcaat ggaggtgggg taaccaaata 279121 actctcatcc ttaatatcca acatagtgtg accaaattgt ttaacagtca gcattaagga 279181 tttagtgaaa ctggctttaa tttggttgta gccttgcagc ttaaccttgt tcttatcatt 279241 gaagatggaa aaagcagtga cgggtggatg gtgagaaact tgctcactta acaaaaccgt 279301 ttctccaaat tcaggatgct ctttattttc ccatttacca acgaacaact cacctagaaa 279361 tgggttcaaa ggttttttct cagaacctaa ggattcatta cgagaacagt attgagattt 279421 taaagtggaa atgaaccatt tagtaacggc cagcatacgg gccaattcgg gtgactcgac 279481 ttcagggtca attaaacagt gttctttgta attatcgtca ttgataaaag agggttccaa 279541 gaatagctct ggatgttcag cccagtactg agaaaactcg gtcaatgaga ttggagataa 279601 aatgaatgga ggagccgata acgaagaaag atcaccattg aatgaagcga ttgacttcaa 279661 gaaagaagtc catgaggatg agcttgcgta ttgagacatg acttgaaatt cttgagacta 279721 aatcttataa atttttcgat ttgtttctag gagaaaagtt tgatatattt ctgttatgtt 279781 cagactggtg atttcgttga aagcgtgaac aaatagccag tttctatcca atgtatagtt 279841 ttctttcttt gtttttttct ttagtacaac agctagaaat tgggtaaaaa aaaagccaat 279901 gtgatagagt caaactcaaa gaaaagttta cttaagaact tatcgacgaa atatcgtttt 279961 acttggaata gtaatacttg cacagctcaa gacagaacta ttgaaaaata aaccagagcc 280021 caataaacgt ggtacttgtc gagtagtcca ggaaatgggc aaaggttgga aaacaagaat 280081 aatcaacgaa cgcaatggca aaaggagaag tccgcatccg tgcacctcac aattccgaaa 280141 gataatgact tacgtgagag ggcccaaaaa tgctgcagct agtaaaacgc gaacggaatg 280201 agttactggt cccgtgaagt gattgacaca atggtcggtg cgattattct tcgtgctgta 280261 acaagatgag gtacatacgg gaaagagctt attttagttc gtttaggagc tccggaaatt 280321 atttgcacga aagttttcgt tgcccggatt gaaaatttac tgttgacatg aaagtacatt 280381 aaaagattag gttctggtat attgtttatg ttttacaaat gatttggacc gggaaattgc 280441 aaaagatgct tccgttgaga ttagacgcga gtgattgtga tgttagtaaa gacgattagc 280501 cgaactattg aatcagaatc tggatttcta cagccgacgc tggatgttat tgctactcta 280561 cctgcagacg atcgttctaa aaaaatacct attagtctgg tagtgggatt taaacaagag 280621 gcctcgctga attcatcttc atccttatca tgttattact acgccattcc cttaatgagg 280681 gatagacata ttaacctcaa atcaggcgga agcaacgttg tggggatacc gttattagat 280741 actaaagatg accggattcg tgatatggct agacacatgg ccacaataat atctgaaagg 280801 ttcaataggc cgtgttatgt aacgtggtca tcgctgccta gtgaagatcc ctctatgcta 280861 gtagcaaacc atttatatat cttaaagaag tgtctcgatc tcttgaaaac tgaactcggt 280921 gagtaaagta agagttcttt agacattcat gattgtaatg taatttaatt aaaatactaa 280981 gtataatgcg gctccaaaat actgaatcaa acctttgatt cgaaaatatt ttggaaaaaa 281041 taaatgattt gattgacttg tcagactgcc atttgtaccc acccatgaat ccctatcctt 281101 ccaaaatgga agcacatagg atgggtcaag atcatcgcgc cattaaatat cgcaacaaat 281161 tccaaaggaa gttatcacaa ttgcaacggc aaagcaaaat tttattcaaa attatagatg 281221 gccgaaccgc taaggattgc ggaccaagct aatttaaatt cgatttcatt tcctcactct 281281 ggggtacaaa ggttatgggg ctcatcaacc aagttggatt cagtggctct tttgaagagt 281341 caaagagtga cgattcctat agaaatgatc ctactgttga atgtgttagt caaaacctga 281401 agctggtgaa atagaagatg gttgttgaat acgacaatcg cattgcctaa ttattgggta 281461 tgctttgtta tattcctaat aaagtatatg gtataaaaca tactgaagta cgtcgacaat 281521 ttttttagta aaaagaacaa gaagagaata aaactaagaa aaggatgaat gagtgaagtt 281581 atcaagttgt ttggaaagag ctcactattt atatgtttct ttaactttac tcattcacct 281641 catcgagaat ggaaaaacta atgaaaaatt cagccctaag aaaaatgctc gaaatacata 281701 tcgtagtagt tacccacctc tcgttgcaat tttttccacg gcaatattaa catccttacc 281761 tctttacacc cttacacttc ctttgattac tttttttttt cttctctcag tttgtttcgc 281821 gtacacacct tgggtgcccg tcgaagaatt ctccgctcaa tggaacgtac ggaggtcata 281881 ctcagcttcc ctctagcagt acagtcgtta gacagagctg attcatcttt tccggcctaa 281941 actcgtatcc tgtccctccc ttctactctt caccggcatg atacctttgc ctcccgtttg 282001 gcaaaatatt cgctatcaag ctttaattta cgtgtattaa tcactagttc aaaacttgag 282061 ttattttgcc ttgagcaatt gtaagaatcc gtaagaaacc aacaatcaaa taaattgaaa 282121 aatggctgaa tcccatagat gtatgttaaa actgatgacg agaagacatt aaaaatattt 282181 tgtgctagta atttggaatt ttcaagtgaa acgttgataa taaaggaaaa agcgacttca 282241 gaaaagctac cagatcatat acgtggtgac taaaatgtgc aagaatatag aaagtgtaag 282301 atgaatgcaa aactcagatt taacaccaga cagctaaagg gtccaagtag aacaaatcaa 282361 gtataccaga actatatcta agttttatct ttataataaa agagtctact atcgtttctg 282421 ggtaacttat aaaataattt gcagtatcga aatttacgag atcacattta ccatcgatat 282481 ccaatttgac tgttaaaagc tctaaattat ggcattcttc gacaatggag aagcctaagc 282541 ttgatgatga agtcgcataa ctcttcgata atacagaatt tgctagctca ataataacca 282601 ccatctaaga tgatcattaa atactaacat tttgttttgg gattttattc cttttttttt 282661 tttagtgtac gtcaaaggta agcacttatc ctaccaaaga tccaagagag tcaacaaccc 282721 aaatgtctct ttgatcaaga tcgaaggtgt cgctactcca caagatgctc aattttactt 282781 gggtaagcgt attgcctacg tctacagagc ctccaaggaa gtcaggggtt ctaagattag 282841 agttatgtgg ggtaaggtta ccagaactca cggtaactct ggtgtcgtta gagccacctt 282901 cagaaacaat ttgccagcca agaccttcgg tgcttctgtt agaatcttct tgtacccatc 282961 caacatctaa atttgttgat tgtataagta ctctattaaa catcgttatt ttctctttta 283021 ttactattaa tattattata ttttgagaat agaaaagact aatatatata tagtataatt 283081 tttaaaatta attccgtaca aaaggcaaaa gaaattgtct tcttacttaa aatgtctgcg 283141 aatctcgctg taagcgcagt gaaacaatgt tcccgcttag aagacgtgat tcaagcggag 283201 tgaagctatg attgataata agtaacaatt tagaaaaatt tttgatgttt ttagtaatgc 283261 aaaatatata tggtaggtat atgcatatat atgctcaatg tttattagat tgaaatttca 283321 taaagtatat tataacatta ttttgttggt ctggcaaatc gcaaaatttt agcgacagac 283381 attttaaatg gaaaaattgc agatagtact gattttttca tatgataagt ggatattatt 283441 gtcaaatgag ataggtatta tctctagatt ttcatacttc ttcttttgaa aaaccctaat 283501 actctttttg cggttgaatg ttctggactt tgggctgctt tattgtctac gcttgccttg 283561 ttgacctcag ataccattat ggaggacctg ttgcttcgga ccgctttttt agtttctaaa 283621 gtacatttat tttgcaccat cgttggtgca ggcaggtctt ttgagacttg atgggatgtt 283681 tgcatatttg aagcagtgat ataatgattc tttgaatttg tttgataact gtcatccttt 283741 tttgggcgtc tttgggaagg tggagaaggt ttccgtttgg aatccattga tgagtataaa 283801 ctagatttgg aagtatcata agagtacaag gaaagaaagc taaatctttt ctttgttgac 283861 tctgcttcgt taagtgatct ttctagatgg ttattgacgt gtttttgtgc tgtagctttc 283921 gcgatgttgc tacttttact acccttttca cttgtgtcct ccgttttcgc cttatcaatt 283981 gattcttgtc cttcatgttg ttgaagagga gattctggtg gcctcaattc atcagactct 284041 tcggtgaccg tatcgcatga gatgtcactg aatatgccgc tatatctcaa acttttgcgc 284101 ttctgtttgt atttttcatc atagattctc gttactacat cagcgtccct cttatacttg 284161 atcaagtcac cagatacgct ttgcaaatca acagagggtt ttgctactga aaattggccg 284221 tgcgtaatta actttggaga gctttcgatg gaagaggatg aggttatgca tgtatctagg 284281 gcaaggtatg gtgtggaatc aaatggggat gtgtctcttt gattcagcgt ttgtgatgaa 284341 gcgctacttt tagctttttc gttgatctca tatatggaga gcgtatttga attgtaggga 284401 ggtgttgtgt atgagccagg atggtatgaa gttggccgtg gctttgtatg ggatgaggaa 284461 gacgtacggt agaaattttt agcagattgg agactatttt gggtcttatt tttattgtat 284521 tgatgatttt gtgatgaagc catgttattt ggttgaatct tgcttgtttg cattgtggta 284581 gacgactctt cttctaaact tggtacaata ctactcccag aaattgtatt tcttttaata 284641 ggtgtggttt cgattataat atcgcctgga cttatggctg gtggaggtga aagactggca 284701 gtcatgtttc ccgtagtttg tctaatgttt tgtactgggg ataatgattg ttcatgactt 284761 aacacatatt ccctatctgc gttcaccact gcctgcaagg caacggatgc agcagagtta 284821 cttctattgt gcctattaga tcttcttata ggtgacagcc gctggtcaga tgcaatagaa 284881 gccggtctgg ttataatatg attttgtgat tcttgaggcg gagccgggaa agtaattaaa 284941 gttgaatcaa tgaccagtga atccctttta tcactccttg agccaagaga tgaggtagaa 285001 caactggatt gtggtctaga tccatatctt cttcttggtt ttgctaatct gaacacggat 285061 tgagtattgt ttagtttgtc ccactcatca ggtgttatgg ataagaatga agaatgaggc 285121 tttagccatt catgtttctt gatctgtttc aggtttattc ttttctttgg gtctgagacc 285181 agcatgcgtc ttaataagtc ccgaggtata ggaagaatat aatcagggaa ctttaatggt 285241 gtggagttaa tataattata aagtcttcct atatcgctgc cttcaggatt atttggatca 285301 tcatcccacg gtaaatatcc agctagtata gcgtaaagta taactccaca tgaccatata 285361 tctgcttttc tagcttcgta tggttcggcg cttatcacta gttcaggcgc tgcgtagcat 285421 ggagagccac atgacgtctt cattaattcg tttcgtgagc aaaactcatt gacaaaccca 285481 aaatctgtaa taactaggtt ctcattcttg tctagtaata gattttccaa tttgagatct 285541 ctgtgaacaa gtcccttaga atgtatgtaa tgtactccac ttattagctg agaaaataac 285601 ctgcatgcat tcatttcctt aagcctcctt tttttttgaa tatatttata gaattctccc 285661 ccgcatgcgt actctaggac aataccaatg tacctagaat tttgcaacac ttcttctaat 285721 tttacgatat tcggatgtga taagtgtttt aaggcgttga tttctctgta tattttaact 285781 tctttcctgt aatcattcga tatgctatca cgtttgataa gtttaattgc tacttgtttt 285841 gggaagtcaa aagttgaatt agagctgttt gaaaaattct ttggccagcc tagcttcact 285901 tttccgaact ctccttctcc taacgtcgac cctaggatat aaggaccaaa cgttacatgt 285961 ttccgccttt gctcatctgt tctttgaggg tactgaaatg tgtcagacaa atcgttggta 286021 aaccctccgt agtatgtatg acgtttattg gtgtacgaca ttaaattttt ggcactctaa 286081 atcagtatat agaagtaatg gccaattgaa tattgaacgc cgcttggctc gcctttcttg 286141 tattgtggat gggtaaaaaa aatagcgatt attgttaggt ttaattagca atcaaaaaat 286201 tctcgcaaac acgtcacaag aaacaaatta atgcaaaatg tggcacagtc aaaaaactgc 286261 gaaaatgtgt taaagatgaa aagaaccgtg atcagcaaca gcagtgtacc agattttgtg 286321 atctgattta ttatagattt actcgatgac ctgaacttga attatattta aatcgatgaa 286381 ggggttgaaa caggtgttga tctgggtttc agaatttttc tcttgtttac cttttttgct 286441 gttctacact cattctttcg attgttttca attgcttttt taggaagtgc ggctttgttt 286501 acataaaagg tgtgcggcat tttaatgcaa tatgaaattt aaaagtatat gtaacgatag 286561 cactattatt tagggttcct gaaatgatat actttatgga tagacattat ctgttcattg 286621 agtatacagt aggggctaaa ccttctttta agggagtaaa aaagatggat atgcattacg 286681 tcggccacat gacattaatt gtgcaggttc agctgatgta taggctgaag aggctacgct 286741 tgctaattta taatgccatt tactaaccta aggagaatag aatctcccat agagtgagta 286801 tgttgtgatt aaagagatat ggtttcatct ttactcgagt ccattttctt tattttttta 286861 atggtaagag gatgagtata gcaaaaacgg tcaagagaca gcagtaagtg tcgtcgtaac 286921 tagaacaaat aggccttata acagaaatca taagggttgt cccgtggtcg gagcccttgt 286981 cggaactaaa gaaaatcagg caatatagag gatattttct acgtacaaaa cgcttattgt 287041 atttatagct ccagttactg aagtggtaac ttaagtaagc aataagtatg ttaaaaccct 287101 tttatttttc tgagtcgagc agatttttgt tcgaccgttg tatataggat aatatgacgc 287161 catatgattt tttcctcttt ggtagggagg gaagaaattt tccccgcgcg gctgagtaca 287221 aaagcgccta gtactcactt gagtcataat ttagcacatc atagcgtgcc tgccagaaag 287281 acttggatgc gcatttctat ttgatgtaag taaggaaata ggagaacttt catagcccat 287341 ggctagttcg gttttcagta aactatatac gtatatgtta agaatatttc ggagtgtcta 287401 gataataaaa gaacatcgtt aaacttatga atggtgaagg aggagaagtc tcgttaaaga 287461 attcctgttg tagaaaaagt cagttctggt tacgagagga aaatgttgga agtttatatc 287521 ccatcctttt ccttttccca gcatttcttt acaaaccgtt ccatgttgac tttttttttc 287581 atttgcccta caatccaggg atgctttaac atttgcctgg gagaaggcct ctctctggca 287641 tcttttttta aacaatagtc gataaaagat ctaaatgtct tgctccagga tatgtctagt 287701 tctggctcat ctttcaactg gggagaaaac gtcaggatca tcgtcaataa ttctatagga 287761 gccacgtttt gcgttatttt gtcagattca aatggaaatc tccctccagc aacctccaga 287821 agagttaatc ctaaggacca tacatcacag gttacgctgt atggttggcc ttgtattcgt 287881 tctggggcca tataaaatga cgttccagta aatgtcatcg ctaaagagtt aacagcctcc 287941 ccactgacac cgaaatcgca taatttgatt tccccttttt cattaagaag aatgttttgg 288001 ggtttaatgt ccctgtggat gactttcctt tcgtgtaagt atgataaacc tcttaagaca 288061 gattctgcta tctttcctat caccctctca cttattctac cgccacgttt caacaaattt 288121 ttatacgttg cctccagtga ttttcctccc atatattcca tggcaatgta tattgaagaa 288181 ctctgttcgt cggtaaacat accatagtac tgcacaatat aatcggactt aaaactctta 288241 ttaaattgta gctctctgaa tatttgcttt tgatattctg ggtcagtatt catagtgttg 288301 attgtcttca acgcaaaaac cttttttcca ttttttaatc ggcacttggc tacagaacca 288361 cccgcgcctt ctcctagaat tcctagtgta gtaatctcat ccttgagatg cccaaacctc 288421 catgcttctt cctctaactg gtctacgtct tttccttgta ttaagttgga acaagaaatt 288481 atgttatttg cacttaaagg ggcggagttg ctcccgctac tgctgaagtc gtacgcagaa 288541 agaagtgtcg aggggtatga atcctcgcct tctggtgtgt cgagatcttt cttgataaaa 288601 gtggtatcta tgttggataa cttagtggaa attggagcac tagatagtag ttccttgtaa 288661 gttatatcaa catgcaaatt agaaaatctt tcagaaagct gactatcgcc ggcaactcta 288721 tattctatac cgtctttttt ttgcgttagt actaggggag gtaatggagg tggtaccggt 288781 ctatttttaa tagttgtagt agatgatcta ttgtacaaca aagtggaatt tgaagccatg 288841 gatgacgtag tggaagtagc tgaagtgcta ttgttggagt atgggctttc gttcactgac 288901 gagtacggtg accggttgag atgttgccca tcattagtgg atttcgcatt ttgaactaaa 288961 tttactggaa gcgttaattt tggagtcttt tggtgactcc tattggattc tggtggtctg 289021 aacattgaag ccattatcct gtgtatataa ttggtatttt gtagatatga taacagtgcc 289081 tgctatgcta atcaggtaat acttgctact agtaaaatgt ctaatttttt gagcgaacga 289141 atttcatgca aattagaagg tagccaacat ataaatatat gaatatatat gtgcctacgt 289201 gtttgatgag gttttcagta aaattaagcg gaaagtattg agctttccca actgatccct 289261 ttgatttatt ctctttctaa ttcttcaact ctaaggataa agtttatttc tttttgattt 289321 tttttcgcat tgagaaagtg aacataaaca agggtaaaat aggctcaata tcagttcacc 289381 tttgagagtc tggcaataag agatgtggtt ctaaggttac cttatacatt ctaaactctg 289441 aaaacgcgtt ttcaaaggta tgtacatttc tctatattaa agagtagatc cttgccgttt 289501 atatatacat gtagagcaat tctcaagcta ataattaatg tttacttcag acaataaaac 289561 attaaaaaca aatttttaga aaaacaaaag ctgaagtaaa gactaaatat tacacaattt 289621 attcatacat ttccgcccca aactcaaaca gcctaaataa tataaaaatt aacttttggc 289681 agctccaacc tctctactgc catctaaaac ttttccagta aacggcttat atacagttaa 289741 caacccgtca ctatcaactg tagcaactag atcctcaatg tatttgtgat aagcaacggt 289801 attaacctta ttattttctc ctatttctct tctgcagccc tcagtgtgat aaaatgccat 289861 gctttcggcc tccaattcgt cagatattat gccttgaaag tcctcatgta tctcgttata 289921 aatggcaaaa acaggttcga aattccagtg gtaaacatta cctaaccctc caattgtaac 289981 cacttccata ggcgaaatgg aagaaaactc tattttggac acttgctcgc tataaaagtg 290041 atgaactttg aatagttcat tgactttatt atgtccttgg ttgatattta actcagcatc 290101 agcatcccct aaagcgataa ctgcacgtat atcccaaacc ttgagagccc caccactagt 290161 tcccgtcata aataatgtat caacaaacgg tgatgcagca aaacaagttg ttttgccgtc 290221 caaagaatcg tttagaatcc aaaggggctt tttgcctatc tcattacccc aaaaccttat 290281 gataccgtca tcagaacaag tggcgaatat ttgattattc aaaaacttga tttcttgaat 290341 attctttatg ccaggaacag gtattgtacg aagcacttct cctattttac ctgagttgtc 290401 tatcaatttt attgtagcgt tttcattatc aagatgtttt tccttagtta ctgttaaggt 290461 ttttgaatcg ttagaaattg caaaatcaac acagggttta ttttgatttc cggacgatgc 290521 tgaacttaga gaagtggatg gctccatcat tgtgtaaacg ggcgatttga caccttctct 290581 gaaccatgcc aaagaaccat tggtagaaag ggctatcacc tttacattta tttcgctgtt 290641 atccacgtaa atcatctttg caatcgtttc acctttaaat tcccattttg gaatcaaaac 290701 agtctgctcc accttttgag attccatggt ataatccggt tgtactaacg gttctgaaat 290761 gctttcaggt tttttgtaat gaagtccgag tggcactata caatccacct caaagatttc 290821 actcccttga gaatataaaa gtggtacgct caaaacacct ttggatttat tacatgagct 290881 atcgttagtg aaaactatac tcctaagtgt cgatggagat tcgtcaacgc ctgagccaaa 290941 gataggcttc aaacttgaaa tatgttggta taatgagggt attgattttt tccaaatttt 291001 gaattcttca ttttttattt tgttgtcttc tgcaatatct aaagtgctca ttttaagtga 291061 ttaaagaagg aaataaatac gatactgaag gtatgcggct gaggagtggt gctttttcat 291121 tcattcgatc atgaatatac aaagtattgc ttgaaaaaat caatatgcgc ttattaaaat 291181 ttcgcagcaa aatcggccga acccttgcaa aacagagata gctccgcttt attcacgtga 291241 aatggggtcg aaattgaaga ctatccaaat aggcgttgcc tatgcaagga cgctccaatt 291301 gatatatcat cactacgaag tatatatata tgtagaaact gatatttgat taggctccaa 291361 cgccgttaca aacctcttct taaaatttcc tcatagtatt gtatatttag ttgctttttc 291421 ctggcctgta tcagatgttg caacctttct tgcatagatt ctaaagagtc aatctgctgg 291481 aggtattgtt cctgattagt agacacccaa tccaaatgtc tgttacactt ccacttcgtg 291541 catacctcat gtattttggt ggcttcctca ttacttccaa aatctctgac aaattcttcc 291601 acagagcagg gtattcgctc gtatgtagaa caatagccac atatattttt cctagcccta 291661 ctcctgctgc tatttttctt cttcttcctt tttgtcccct tggaatcttc tttaccacat 291721 tccacatggc ttgcagcatc atcgtccagc ttgcgcattt cggtatatac gttgtctaac 291781 catcccaaat atacttccaa aagttctagc ttttttttga ataatggtag cgatatctct 291841 tgaacctctt gcagatcatc ttcaagagtt tttaacgtca tgtctcgtac aacaatttga 291901 tcgaatattt ccttttcgtc atctgttttt acaactatat tgttatcaat gaaatccagt 291961 tgtccaaatt tcttgaattt atctatgtgt cctgtttgtt cgaccatttt cttgacgact 292021 gctctatcct catctgtttt caatcgcgac caaatatcat tcacaaattc tctaccatgt 292081 tcctcagaac agtatttact atcctgtaaa catggtttgt agcaatcact tatcctacat 292141 tttcttttcc ataaggtttt tggcaagctc ccttcaccat tgattatggc gtccttattc 292201 ttaccagtaa tccccgcttg acagtaagga caataaaaag agaacaccag gtccttaaac 292261 tgctcaggaa tatgaaggca ggtgaaatga aaccagtcat cacaaccatc acatcccacc 292321 atcagctccc catagtctgg ccttttacat atgcagtata cgtcctctcc tgtagttgga 292381 tttcttttta aggtggaatg cggtggacac cattgtggta atgacattag aaagataggc 292441 tgagaaatta ttgaggtcga agtagccttt tccaaatctc ttgttttttt tcttctgatg 292501 agcttcgttt acatttaaaa gtaagcattt acaaagccca attgaaattg ttcatatttt 292561 acccgccttg ggttatatgc agtgtctaat atgtagccga acatatcaat tgattctaaa 292621 gaggtaagct taatcctctg tgctttaatt catcttaaaa agtttatctg ttaagtctat 292681 cgaatatcgc caaatttact ggcggtatat ataaataaat atggaaaata tgaaaggttg 292741 ataaaaaaag ttttatgcag tgaaaaaaag gaagaagaaa atggatccat cagtgaagag 292801 aaggattcat gtatcttcaa agtctgattg acctctccat cgacaaatta tttaatagtt 292861 tgtcataggt agcagtgact ttgacttcac aatttgggtc gtcagttgag actgcaggca 292921 atgtttctac ggatccttta tcggtattgg gcgcagatac atcagaatcc acgcctggtg 292981 taaatgtcga agcgctattc tgaatggatt caccataaat gttctccaat tctatgttgt 293041 tggagttaac gttctgaatc aaatcatcga tagaatcaat acctttagcc ttcatgattg 293101 ccgatcttaa gacagcaccg gatggaattt ttggtaaaat cttaggatta gctgggctaa 293161 ataaactagt ggtagcagtt tcattgttag aagttgaaac tgaaggagat gaagttgact 293221 taccagctgt ttctgtgttg ataggcgtat cacctgatgc aaaaggtgtc tgccttgttg 293281 attcattttc agggtataaa gacctctgct gctgaacgaa gaaaccccat ttatgtagtt 293341 caccttcttc ttcttcctgc tttttacaac ctacagaagt actagatgat gtatgcttga 293401 acaccaatgg tttgcctgtg aaaacgtcaa tagttttacc agaatcggtg gccattaaat 293461 gtggtcttgc tgtaattaca tcattctcag gttgtatttt ttcttcggga acatggtatc 293521 cggattcaac gtgcttcaat gctggtaatt ttgaatcttc gctggagtca acactttcct 293581 tcgaatcatc cctgctggat ccaaggacat cattcagatt cggattatgc gaaaacaatt 293641 ctagtatatt gcataagttt tgttccaaaa ggagtaatct tacaaggttt tctttttctt 293701 gcaatggcaa ttcacctgat ttcctttttt cgaacatagt atctattgta tgctgaacat 293761 tatggtgcaa gatatggaac ttttcaatat attttttcag caaatatctc ttcgtggtgt 293821 cttttttgac ctttgtactc ttatcgctta acaagttcag tttttctaaa acactttcag 293881 cggtcatagt tactaaagag ccatcgaata gcaaatcatc ttgcgaatcc aattcatcta 293941 actggaaagt cgaatccatg gtccgtttca tatttctcat caagcacagt gctattcttg 294001 attgaatctc ttctgatatc aaatcatagt caaaatctaa accaatcaag tttggagagt 294061 ctctagcaaa tgcgtaaagt gtggatgaaa aactattttt agcaaattgg cccttaacgt 294121 ccaatgtgct cgaactatcc aagtcgccgt ctgtgttagt ttgttgaacg ggagaatctg 294181 tgccgttcat tagatagaag ttttcaacgt tttgattagt cattgacaca tgcgagagcg 294241 atttgcactt aatcaaaata ttacaaacga cagctagttc ctttaatgtc aaattattgc 294301 tatccaaatg tatcctcttc aggttcggaa atcttggtaa atacttgtac atgtagggta 294361 aaatgtcagg aaagcattgc gacaaattac tcaaatccaa aaaaatcaag ttaggcaact 294421 tagaaagata tttcaagagc aaagctaaat cataagaagt cgaaatatta gtgctgttca 294481 aaatgaaata tcttaagtta tcatatgata gagcagatag tttaccaacc attggcttaa 294541 tcatagtgga cagatcatta aacgctagat ccacaccctg gacgttatat tgagacatcc 294601 aattgaagat aaatttcaga caatcctgag agatattgga agtagtggca cctgctaaac 294661 caagcctgat gcccgattct ggaaagtttt tttgggtagc aaaggatgtc agtaaacgtg 294721 caaagcatga gtaaggaatt ttgctaaatt gaataccatt gaataacaat tcttctatag 294781 gtttgtgaga tctctgagac aagacgtcag taaacaagtt ccaatccatg ttatggcgat 294841 atagtgattc agcaaggtca gatttgattt tcgtttggga aatgtcgagc ttgttcagtg 294901 atttgtttag caaaaggaac ttacatagta atttccatcc atcttggtcg attcgtacat 294961 ttcttaaact caatttgtcc aaaactgtgg agtttaccaa agcagaaata attattctga 295021 acatatcctg gtttaaagct acattgtcga aaacaatcgt gtgaatggga gcaatggtga 295081 tgaaatcaca aaaggaaaga atatcgatca aggtaggctt agggttcaaa aacttcaata 295141 tttgcaaggg agctgtcttg tcctttactt gtcttagggt agacggaatg ggtaaaattt 295201 cccttaaatg gcagcatctt gtgtaaataa catccagcgt aacttcgtta ttttcaatag 295261 aatgaccgtc ttggtactta tcttgatcag gttccttgaa atagtgctca tgcatatgaa 295321 tgggcttatc aatgccggct tttgagaggt tttctgcaag tttattattc tcaagctccc 295381 gatcagcttc aacatttgga ggtgacacct cttctctttg cttcgtaatg gtgccttctg 295441 atgacttttc agtaagctta ccgcctgcat ccgaagcagt cttaaaattg gctacttcaa 295501 aggctattct attagcagca aaatgagctt cttgctgatg cttagcagcc tcccttaaag 295561 ccaacttttg attttccagg gcgagtatat attctttaga cttcttagtg tacaacggtc 295621 ccttaatgtt ggaattggtt gacttggccg attggttgct actggaaata cccacggaaa 295681 tagaaggaac ctcgcttatc atgtcatcag ggataaggat gtttcccttt tttggggttc 295741 ttgaaggaag ttgttgggga ggatcggatt cgaatttatc gacggcaaac gagacccttt 295801 tcaatgaaac tgtagatagg tcttttactg caagtgcagg ggaggggagt ataggtgtct 295861 gtggcttgct agctgttggt gccactcctc tcattggtga tgatatctcc ttcacccgtg 295921 gatcaggagt cgcaactgct ttaatgccac cagactcatt ctcagtcgtg ctagtattaa 295981 caacaggtaa tggtttcttg gcagtggaag ctgaagaaga ggtagaccgt ttgctaaaca 296041 aagatccaaa aatcgacctt ttagtctttt ctccactagt cgagttgctt ctcttgagag 296101 tagcattaga tggtgaagaa attggcgggt gctttccctt gccaacagaa gaagatgcgg 296161 tggcgtttat ggcagaactg gccagtcttg gtttggacga gaccacagca ttggatatag 296221 aagtggaacg ttttttcctt acaaattgag tacttgagcc gttgtcatca ttatctataa 296281 ggtctatggc gtctacggta gccggattat caatgtcagc ggaatcgctc cggttaccgc 296341 tattaatagg agtaagtagc ggtatgttat cagtgtctga tgcagaggta ttaccatcgt 296401 tcctcttcaa atctggtttc tcagtattac aaagtgctgc attggataca gatgacgacc 296461 tcgcacgagg cttatcattg ctagacctgt taccactcgt gctattgtct ccgtttttcg 296521 aagaggacgt agatgaagag gaggctggcg acgtagaagg cctcgatggc ttcgtatttg 296581 tcttccgtct actcttacct ttatacaacc aatctacggg cacatcgaac tcggtgttag 296641 ttatcataac ctagatgcta tctccactcc ctatgcttgc tttggtggac tattgtttcc 296701 gttattcgca atttctatag gactactata gattatataa actgaatttt agctttatgc 296761 tgtggtgtta tttcccaaaa cacgctcttc tttcttacgc tttccgttag cttatttgct 296821 cacggtatca agattacttt tttttttttt tcttcttttc tttttcttgc actaccctct 296881 tcttcttgtt cttccttgcg tttttacccc tcttcccttt attttgcagc aaaaagaaag 296941 atggaaaggc aaaagtgaag gcatgatgat gacaaacttg aaaagaaaga gaacagcgaa 297001 aagagatgaa taatccatgg caatgactgc acgctcatgg gtatcaattg gctaggtcta 297061 atattgttat tgtttggagt atggcgtaga gaagtggttc cttaacctta attaatgccc 297121 gtgccatgat gattgcatca ctgagacgta atgtggaaac accacttctc ggtccgcgga 297181 catcaaccga aggaaaaatg acaagctatt tccgtgtata tccgcgccaa tcccttcggg 297241 gccgaagttc ggaggcttta tctccgctta gccaaggccg tcaaaggcga taaggtgcgt 297301 tgcaccccaa ttagccatgg agaaggaaaa aaaaagcatg tatgatcatg atgatgcaaa 297361 aattgagagg aaaaatgact caggctattt atataagtaa atgaaagggt ttcgttgtag 297421 ccttttctgc tctcttcctt cgctcttccg catatatatt tgtgttcaga gattattctt 297481 aaatccataa gaacatccct tcatataaca attgaataag gaaaacacaa cacataacac 297541 atatttaacc tgatgcttcc tgttataacg agatttgcaa ggcctgctct gatggccatc 297601 agacctgtga atgccatggg ggttttgaga gcgtccagca taacgaaaag gctttatcat 297661 cccaaggtca tagagcatta tacacatcca agaaacgtcg gctcattaga taaaaaattg 297721 cccaacgtcg gcactggtct agtgggtgcg ccagcgtgcg gtgatgtgat gaggttgcag 297781 atcaaagtca acgactctac tggcgttatt gaagatgtca aattcaaaac ttttggatgt 297841 ggctccgcca ttgcctcctc ttcatatatg actgaattgg tacaggggat gaccttggac 297901 gatgcggcaa aaattaagaa cactgaaatt gctaaggagt tgagcttgcc cccagtcaag 297961 ttgcattgct ctatgttagc ggaagatgcg atcaaggcag ctattaagga ctacaaatct 298021 aagagaaaca ctccaaccat gttatcgtaa tgaataagaa gataaccggg acaagaacaa 298081 gatcaaaccc tcactaatca acaagttgga cttaatttgt gcaagcatgg atgtttctca 298141 ttaatattgt catatttctt tcccttaatc tagcatttcc tttctctccc tcttctcatg 298201 catatcttcc tagatatatt tctccagggt gaaagcggga cggacgtgct tgttttacct 298261 cacctggtac tactagtatt ttcattactc ttttttcatc ctcccacttc ccccttatat 298321 atttgttttc ccatgtgtgg tatatggcat cattattata taaatattct ttagttgtaa 298381 aaggctgttt taattaacac tatttatcgc tagacaaaac tagactttca ttatttcctt 298441 catttcaacg cttgtttaaa catgtgctag gtaagcgagt tttttacttt tacttccaat 298501 aaatatatat atatatatac gtatacatgt atgggcgggc tacaacaaaa tgaaataaaa 298561 agcgtcagga tcattgtttt ttaccatact tgacttctct gaaaaaatcc atgacgttcg 298621 tgaaaactac caacaataac ccaccaccgg gggcaagtct catgaccttt ggcgcaaatc 298681 ccttatacaa tgctttaaac ccttcctcac ggtaaactaa cagcactgaa ggcagggacc 298741 agttgtactt cctcagcggc ccggaacttc tttggatcct agattttacc acgtcaaatg 298801 gtgtattcaa caagcacccg acagtgccac caatagcacc tgcgatcaaa tcatttctgg 298861 tcttttccgt gcttgtttta gccgccggca aaagcttccg aatttggaat attataccga 298921 aataaccggc attccaaaga acgtgtctcc agatagtggc ttccaaccca ttgaaaagtg 298981 acaaaacacc acctttcaca acactattct ttacaacttc aatgggtgtc ttgaactgtg 299041 aattcacatc ctgtaatcta atcttcacta gttcaaaagg cgcgacgaca aaggcttcca 299101 cggcgccagc ggacgcacca ctgtatatgg cgattttttg agtcatctcc ccattgggcg 299161 tggggaaaat ctttttataa aacgtttgga atgtatcgtt tccggagaac ttaattgctc 299221 ttttcggagc ctccattaat ataggcgatg tgataccctt gtaaagatgc gaaaatcctt 299281 ccttcttcac aatttttgta agacaatcca tcacgcccgt gtagtgatct actgctgctt 299341 tcgctgcaac aacagcggga tgacctttgg ttgtcacttg taattgcatt cttgtcttca 299401 ccacgtccaa tggatacatc accaatagct ccgagacgcc ggcaatggca ccggctgtga 299461 actggtatat gaacggcaaa ggtctattat ctatagatgt catcttacag ttctttttct 299521 ttcaccctcg ttacagttct atcttgagaa taaatgagat aaaggttccc aaaagtcact 299581 gatatatatc aacggcggtc accctcacag aaatacccga gaatctgccc ttcgccaaat 299641 cagattcagc cagttcgcag tttttttccc tatctctggt cgccgcatta tgaaaagatc 299701 ctggggtaat aatgggaatg atttgaaaaa aaacaaatgc tggtagaaaa aggtcttcgt 299761 attgctcgta gtaatacggc tatttcaagt aactgctcgg gccagcggct tgaggaaaaa 299821 gtaaacccgt tactttgctt tttaatgacg ctggaaatac caattaccta ctatgtatta 299881 cttatgctta tgacaaaggg atgaaattcc cgacgatgca aattgggatg ttgtacctat 299941 cccttctgat agtgaaacta aaacagcatg gccgtttgcg gattccatct ttggttcgaa 300001 gactacaact tgttaaaaca gccttctgac ccttatcaaa cgctatggac ccgtattttt 300061 cccagaaatt cacagcgctt tcttctgtca tcaactcgta gatcgcaagc tttccatcgc 300121 gtaaatcatc gactgtgcag tcaaccagtg aagcaaactc tttattggct ctgtaaatct 300181 caccggtacg cctacacaag cacgctggca tgctcataga ggtgaaaaca cgatcataag 300241 ataataacat cctctcgaag ctctcctcca ctaaaactaa gtcaacatcc ttcaatgaac 300301 gcgcaatggt tctaaacgcc ggtctaatgg tggatagtgg tttcagaatc ctttgcttgg 300361 aagactgatt catatatttg tccatgtagt cttgtagtct tgcatacccc ttggcataat 300421 tatacggctt caataatcct gcttcaagct tcgcatttat gaccaacttc agccggtgtt 300481 ctggtgtcat ctctgttgac ggatccgccg ctgttaaaaa gaattgttcc ttcggtgtcg 300541 gtgcactgtt ttcgtttgca ttcgctagaa ttcgagactc ttccttttct tgatcttgtt 300601 tatccccttt cgagatacta ttggaagaac ctgacataat agtaggcgac ctattttctt 300661 gtcttgccac tcctatttca tccctacgat tgtcgttttg gtactctaat ggcgattgtg 300721 tggtttgtga gccattttcc aaatgaacat tgctcgcact gctggaactt agtgatgttt 300781 gagtcaatag aggattttct agcatagaaa gaaattcatt caaagaactg aattccgaac 300841 caacattctc ggacacaaat acaggttgtt gcggaagcag caagctggtt gtatcattta 300901 caagagagga gtctagtttc ggtgacagtt cctctccata tgtggatcca cttttattga 300961 ctggttcatt ctgatagtca gacggaattc cagtgtgtgc tttatttgca tatttgccct 301021 gtatattatt atcattcgga gaactttcgt gctgtgatgg catctcattt ggaaccgcaa 301081 tatcatcttc cctgcataaa tgggcaatat ccctcttgac gcacctagaa catggacgtt 301141 gcttatcaca tacaacatgt gaccgtttac aaaataaaca tgttttaaaa gccttactgg 301201 ctcgttttac accactgttt gctgacatta tttcgtcagt ttatataaat atgtgtattt 301261 tgtgttgatt aaaattaaaa aaaactttat ctcactggca aagaactccc gcaaattttc 301321 tcataagaat tactttcttc ttccatccca gagacctcat ccttttttct aatattcaac 301381 tatttttcat tttccttcgt actctttgtt ttgctttttc ttgttttctg ccattccaaa 301441 acattattct ccccatctaa ggagcggatc tgtaggaaaa acagcgtaac cattggaaaa 301501 ccctttccct aaccaatgcc ctttgacgga tgaaacatga tatatctttt aaggacatag 301561 atactaacca atacaaatca aagaacagtg aagagtctaa aggggcagcg aacgcttaag 301621 tatcttcttt aaagtaataa tattcctgtc gcaggtgaaa tagcacttca gcgcacaaac 301681 aaataatatt gcagccaaaa ttccctaata ttgtcatgat aagaatatgt cccattgtta 301741 gatctaaggt tccactgtta ggaacttttc ttagatccga ctcatggttg gcacctcatg 301801 cgctagctct aaggcgggcc atatgcaaaa acgttgcatt gagaagttat tcagtgaaca 301861 gcgaacaacc aaaacataca tttgatattt caaaacttac tagaaatgaa atccagcaat 301921 tgcgagagtt gaaaagagca agggagagaa aatttaaaga tcgtacggtt gcattttatt 301981 tcagcagcgt cgcggtactt ttcttgggtt tggcatatgc agcggtacca ctctatagag 302041 ccatttgtgc tcgtactggt tttggtggga ttcccataac agatagaaga aaatttaccg 302101 acgataaact cattcctgta gatactgaga agagaattcg tatctcattc accagtgaag 302161 tatcacaaat tttaccgtgg aaattcgttc ctcaacaacg tgaggtttac gttctgcctg 302221 gtgaaacagc cctcgctttt tataaagcca agaattacag cgataaagat attattggta 302281 tggctactta tagcatagcg cctggtgaag cagctcaata ctttaataaa atccaatgtt 302341 tttgctttga agaacaaaag ctagctgccg gtgaagaaat agatatgcct gtcttctttt 302401 ttatcgatcc agattttgct agcgatccag cgatgcgaaa tatcgatgat attattttac 302461 attacacatt cttcagagct cattatggtg atggtacagc tgtaagtgac tctaaaaagg 302521 agcctgagat gaatgcagat gaaaaagcag cgtcattggc taatgctgct attttatccc 302581 cagaagttat agacacaagg aaagacaact caaattaatt gtaaatacaa agtcattcaa 302641 tgtacataaa tactgttatg cttttgaatt aagtaaaaca ccatgacttc atattgagat 302701 gttttaagca tataatcacg gcaccgaact tcttgtaatc atcaaatctt tgttttctag 302761 ccgtcataga aatgaagaaa tgaagattct tgttcatgtg atacagcttt tctagacagc 302821 taacttgtac atccagacat cctaaaacac ccataaagca aaaaaaatta ttgaaatatt 302881 ctcttttttt tctttttttt ttttctggtg gctttcaatg cggaatcgct cacatccgaa 302941 aatttcagag gcttcactta gcgtcgcaga tcccagtagt cgccagatgc tttgaaaaaa 303001 aaaaaaataa atagaaaagt ttgtagacat atccgatgta gtatatttca gaggccaacc 303061 tttacttttg ttttctccta cacttcaaaa taaaagacac cgtcacaaat ctcagcaaca 303121 atggctttcc aaaaagacgc taagtcctct gcttactcct ctcgtttcca aactcctttc 303181 agaagaagaa gagaaggtaa gactgattac taccaaagaa agagattggt cacccaacac 303241 aaggccaagt acaacactcc aaagtacaga ttggttgtta gattcactaa caaggatatc 303301 atctgtcaaa tcatctcttc taccatcact ggtgatgtcg tcttagctgc tgcctactcc 303361 cacgaattgc caagatacgg tattacccac ggtttgacca actgggctgc tgcttacgct 303421 actggtttgt tgatcgccag aagaaccttg caaaagttgg gtttggacga aacttacaag 303481 ggtgttgaag aagttgaagg tgaatacgaa ttgaccgaag ctgttgaaga tggtccacgt 303541 ccattcaagg tcttcttgga tattggtttg caaagaacca ccactggtgc cagagttttc 303601 ggtgctctaa agggtgcttc tgacggtggt ttgtacgttc ctcactccga aaacagattc 303661 ccaggttggg acttcgaaac cgaagaaatt gacccagaat tattgagatc ttacatcttt 303721 ggtggccacg tttcccaata catggaagaa ttagctgacg atgatgaaga aagattctct 303781 gaattattca agggttacct agctgacgac attgatgctg actctttgga agacatctac 303841 acttctgctc acgaagctat cagagctgac ccagctttca agccaactga aaagaaattc 303901 accaaggaac aatacgctgc tgaatccaag aagtacagac aaaccaaatt gtccaaggaa 303961 gaaagagctg ctcgtgttgc tgccaagatc gctgctttgg ctggtcaaca ataaattatg 304021 gatatataac gtcattttga gatattttaa ataaagctat cttcacataa cctttgtatt 304081 catttttagt taactcattt acatcatcca cttactacat ttgtattttt tttacgattt 304141 gcgtaccgcc tcattactac cctttttttg cactgcagta atagtacact caaatcatga 304201 tgaaaagaga aaagaaaaaa atgccacaaa aagtagttga ttttataaaa gttatcatcc 304261 aattttaggt aattttattc tctttatgta acgaacatat gaagatttct tctctagaat 304321 ggcattctaa ctaagtccgt gccataaaat catcactaac aaatataaga tcacgctata 304381 ctatcaatga agaaacaaat attaatagtt gctgcacaaa gtattttatg ttctactgtt 304441 tttggcgagc gaagtaatgt aggcctttcc actgaagagc taggaggtga ctcaatttta 304501 tacttcaatg aagaccctat agtgattgaa atcgataaga aagctattga caagaagact 304561 ttggaacagt tggcaagcac aagagatgtt gttcttactg atttaccgga cactcttgag 304621 tttatagact tcaacgagta cgcgaaaatg aagtcaaaat cagatatgct actagagtat 304681 atcaacgaat acgaatttga tgattttgaa agaagttctg aaggcggtct tgaagaagaa 304741 gaagaagagg atttaattta tgacttcaat gcccaagctg aagatttggg taagcttggt 304801 tcaaatatat atgaagtagt cgaagaaaag aatattgtta atacttacga tggaaacctt 304861 atcaatgcaa gtacaactga atcaacgact actattcggc ctttcgtgac ttctcactcc 304921 tacgttgctt cttctacacc ttattcgaat atttcatcat tgaatgagga ctacgataat 304981 gcgagcaact ttttgactcc tacaacagtg gctcttgcgg tacttttaac cattttatta 305041 tttatacagg cgtattaata gatcattatt ttatttaaat aagaaatatt gttggctagc 305101 tttcctgttt tatttactgt cactttttaa aatcactcaa gacgagaaag ctctttagca 305161 aagtactgac aaaaaacttg aagtttgaac ttgttacagt attacacgtc aaggctgtag 305221 tgcggtgaaa aaaaaagaat ataccgtaat ttttctcctt cgtgacctcg gagctgactg 305281 atattagata actaatcatg gtagctgtat gttcgttaat ctcttttagc cacccaccca 305341 tatgcttttt gttttgttag ctaaaataat actaacttac gactctattc tcatcattaa 305401 ataaccaaca gacagtaaaa agaaccatcc gtataaaaac ccaacaacac attctgccag 305461 aagtgccacc agtagagaat tttcctgttc gtcaatggag tatagaaatt gtattattgg 305521 atgatgaagg aaaagaaatt cccgctacaa tttttgacaa agttatttac cacttgcacc 305581 caactttcgc caatcctaac aggacattta ctgacccacc atttagaatt gaggaacaag 305641 gttggggtgg atttccttta gatataagcg ttttcttgtt ggaaaaagca ggtgagcgga 305701 aaataccaca cgatttgaac tttctacaag agagttatga agtggagcac gttatccaga 305761 ttcctctcaa taaaccactt ttaacagaag aacttgcgaa aagtggatct actgaagaaa 305821 cgacggccaa tacaggcacc attgggaaaa gaaggactac cacgaacaca actgcagaac 305881 caaaggcgaa gagagctaag acgggcagtg catctaccgt gaaagggagc gtggacctag 305941 aaaaattagc gttcggattg actaaactaa atgaagatga cctggttggt gttgttcaaa 306001 tggttaccga caataaaaca ccagaaatga acgtgacgaa taatgttgaa gagggtgaat 306061 ttataattga cttgtatagt ttacctgagg gattattgaa aagtctatgg gactacgtta 306121 agaaaaatac cgagtaataa aaggtaaaag ggcgttaaat gcgcgctttt atgtttgtat 306181 aaataaaaca cgttgatatt ttgtcttata taaactttat tccaataacc gcgacacctt 306241 accaaacaca tattattaca acacattttt atcttggatt ttaagtaatt atacaacagt 306301 tttcatttta gaaaatgaga acatcaaata tatacattcc aatgtaatag aaaatggaaa 306361 agaaaaaaga ataaaaagaa aaacacgagg ggaccaggtt gctagaagat agggtgacca 306421 cgtcaaaaga atatacctag ggaaccaaac aatgcgaagt taacaaccca tcaaagtatt 306481 tttaatagtg agtggttcaa tagaaaatta gaagtctgtt catttaagcg cgctacatcc 306541 catcttctaa atgaggatca aaacctgtat tgtccgatgt actattgcca aaaagtccgt 306601 tagatggcat attatcacta ttttgcccat gtgaatcctc ttgatgagtt tgagtgtctt 306661 cagtagcaga tgcagctgat gaaggatgct gagataaatt ttgttccata atagttgacg 306721 aatttggaga ttgagagaat tttttctttg ccttgtagat tttctccaag ttaccggtca 306781 cttttatcaa atagtcaggc aatggtttgc cactcttcaa gtattgtaat ttccaattac 306841 gggctttatc tttcagttgt acctgcgtcc tgttcttcaa attttccgtg attttaccac 306901 cgggaccata taaatctaga atcttagacc acgatgggcc aacctctttc aggccttcca 306961 ctaatgcttc ttcttcctct ttggaccaag ttcttttcgc ctttggtttt cttaatccga 307021 tactaccatt attgttgctg ttactgctgt tgttatgaga ggaatgagga ccagagctgc 307081 tgttgctcat cgaggccgca acagcggcat ccacaatgga ttgtgtgata gcggggtttt 307141 tggaagacac atctgtggta ggtgtatgtg tgctgtaatg attcggacga gcagttgaca 307201 aaaaagcaga cgcactgctt ggctgatttt ggtcgtccat gaattctacg gtcctggtcc 307261 ctgtagaaaa gagtacttga ggatcaaact cgttgacatc aaagtcatat aatggtgatt 307321 ttccgcgacc ctttctgccc catatgatga gacccatatt tttattacaa taatccagca 307381 actctctgat aaattgagcc cattcgtagc tctgggtcag agagttaaaa tcttggacga 307441 tctttaaatt ttctctccga cgatcgcacc tttcgacgaa gtccttctcc gatggagtca 307501 aaagtgtaat gtctccagaa tcgccggttc ttctctgcac gagaatatca gccagattgg 307561 atgggaagat taagtctagt agctcttgtt tcttttctaa agaaatttcg ttcgtctcgt 307621 cctgaaactc tttcaagccg gcaatgtaag cctgtgtttt cagatcaaga tataggatag 307681 cctgcgattt caaaaacttt ccgctttgtt ccagggagtt gttaccgaca gtgtttgtat 307741 ttggacagaa aatatcgaga aatatcgact gtagcagctc aaacccgtaa ttaaggcagt 307801 tcagcgacgt caatagaaat gttagcagat tcgcctttct tatggcagta ataataaacg 307861 cttcgtggcc tctcaatata agggggggag gggagttggg aaaccataaa ccaggcgcca 307921 cgtcgtgaac agacagtaac ggagatctgg tgtggtaaat cattctgatc tgcttaaaga 307981 gcttgactaa cgtttgaaaa atttctgttt cgcctgagct taggaaagcc gtctggtccg 308041 tcaaaaccgc tataatattg ggagagttgg cattaaggat aagaaacctc agtagttgag 308101 tggagatatt gtccagcaga cataatgagc atatggtcaa cctagttctt gcaggcaggc 308161 tttggatgat gtcattgaag cggtttaagc tttcgttatt attgggcact tgcgaatcca 308221 tgacaaatgg ggaaagaagt gagtaaagaa aaactaatgt aaaatgattt ctgtcgcaga 308281 tgggacagcc acaatcttaa atgttggcaa ggatatagga gcaaaacgcc aatattgaga 308341 tgattgttta ttataatgtt tacaaggaag ggcaaagcat tgaggaaaat tagtcggaat 308401 gaggtctcgc cgggcttcta cggaaagggg cgaaaattaa tagggcacgg tgcagaatat 308461 tagggcttca aatgttcaga ttttaaagcc ttttcttcaa atacaataat taattttaca 308521 cactgtacct tgcatatata agagaagaga aatttataaa cagtatagtt agttagttaa 308581 gaatggaatt tgaataaaat cataaaggag atatttaccg aataagtaac aaatagagaa 308641 gggagagatt aaaaaatgaa aatttacagt accgccaaca aacacttgaa taagattgaa 308701 aattagagag aaaaaaattt agaaataata caaaatacta atagtgatgg gacacaaaaa 308761 tgaagaaaga aaataggttt gatagtattg ctatcaccat tgacattctc gtttggatat 308821 tcacttttta cgtggagagt ttgaccttct tcttgtttag tttaataatg ccggaggggc 308881 cctttggttg cactaactcg ccgttttcaa cacatttctt gatagcgcta ttgaacagat 308941 agtcaaaatt tgagcttgtt ttcaacttgg aggagaaagt gtccttgaca tacttcttta 309001 aaacgatacg gctggagccc ttaccgtcat taagttgagg catgctttta aggatcattt 309061 ccttgtaggt caatgaagaa ggcgaagagg ccttcttggc ggtaacagta ggcgattttt 309121 ttttcactac tttctttggc gctagcttcg tggatgcggc tttcgctttt gatgcggttg 309181 cactcacaga agtggcggct tgcttgggtt ttggactgac ctctttttct ttctttactt 309241 ctggagattt cttcttggcc agtttcacag caccagcggg tccctttggc tgttcaaaat 309301 cgccggcctc cacacccttc tttatggcat tgttgaagta caaatcaaag ttgcttgcgg 309361 atccgacgat cgggtagttt tccttgataa acttcttgag tgccggacga ctggatccct 309421 tacgttcctt caaagccgtg agcccttcaa tgatcaactc cctgtaactc ttggaggaag 309481 cttcctcctt ttttgccgtg gttttcttga tagcggcctt ggaagttgat ttctccttgc 309541 ctttgctggt tgcaggcttc ttgcccttac ttgtggtctt ggtagtggat ttcttgggtg 309601 ccatgttgct ttagttgtat tataattgct tccctcgctg ccaagcatta tcaggtgccc 309661 ataaataaca actccccaaa tctatagttg ctcctcctct ttaaataaag gcagataaac 309721 aaaaaacttt gaccgcccgc ttttccacac aaaaaacaaa caacagcaga aaacgcgacg 309781 cgaaaatgaa aagccaaaga gaacaaacaa aaatcatcca tcaaacctgt tattgtgcag 309841 aatagctttt acctagacgc aagtccctag gagggggcat ttttgacaca gaatagcatt 309901 tcatcaaagc aaacagcaac ttcttggaga tttgtattgc ttggcatgtc aaaatctagc 309961 ggtcacatca gtagggtaac aaaatagcac gtcagggtta aggcggccta ctgcttaggg 310021 tacgtggtaa gtgatgtaaa atgtgagaag gagaaactag aaaaaaattt tcctttcttt 310081 ttcctagcga tgagatgaga tgaaattttt cgaacaaatg atttttggca cagtttacat 310141 atcagttata ttggctgtcg tcacaggaac tacaagtaca aaccagaacc attttagctg 310201 atcaccagaa tgacgcaatc cctaggtatc gaacagtata aactgtcagt cgtatctggt 310261 gggaaacccg ctttgaataa tctcagttca gtaaccggca ataagaatat cgcccgccta 310321 tcacaagacc aacgaaacta tattataccc tttaacaatc agatcaaggt gtattctgtg 310381 gaaactagac aatgtgttaa gactctaaag tttgcaaata actccttgtt atccggaata 310441 tttctgcaag aagaagagaa taatgaatcg attgtaaaga ttctgctggg tgatataacc 310501 gttccgcaac aagaagacgc tcatctgatt accgtattca ccaataatgg tcatgtaatt 310561 gttttaaatt ataaggggaa gctggtcgag tcccctaagc atttcaaaat ctctttggca 310621 gatgaaaagc ttgcaaatgt tttccatagc gagggcaact atagaatttt gacaacgttc 310681 aaggacccta gtcaaaaggc acataactct ttgcaatcgt acaggttata tgcattaacc 310741 tttgacgatg ctaaaaagca atttgaagtg gctcatcagg cagaatggca caacgttatc 310801 ttgtcaaata tttcttccaa tggtaaactg ctagcgcata tgtgcaaaga cgtctcaaca 310861 aaagatcacg aacacaaatc catctcagtt gtttcgcttt ttgatgattc tgtaaattta 310921 agctttcccc tcggttccat cctttcttca cagactcaat ccctatccta taacacaagg 310981 tacgtttcta gcatggccat agacaatatg ggtcaacaac tggctgttgg atttgcctcc 311041 ggagttataa gtatcgtaag cctggccgat ctacaaataa gactgctcaa atggcatata 311101 gactctgtgc tgtcactctc attctctcac gatggatcct atttgctatc tggtggttgg 311161 gaaaaagtta tgagtttatg gcaattggaa acaaactctc aacaattcct gcctcgtttg 311221 aacggtatta taatcgactg tcaggtattg ggacctcaag ggaactacta ctctttaatc 311281 ctacaaatga ctgaaaacaa ttcaaattct gactaccaat ttttactttt gaatgcttct 311341 gatttgacct ccaaattgtc gattaacggg ccattaccgg tgttcaatag caccataaaa 311401 cacattcagc aaccaatctc ggccatgaat accaagaact ccaactcaat tacctctctc 311461 aatcactcta agaagaaaca atctagaaaa ctaattaaat cgagaagaca agatttcacc 311521 actaatgtag aaataaaccc tattaacaag aacttgtatt tcccacacat ttctgctgtt 311581 caaatttttg acttctataa aaatgagcaa gttaactatc agtatttaac atcaggtgtc 311641 aacaattcta tgggtaaagt tagatttgaa ctgaatttac aagacccaat aataactgat 311701 ttgaagttca ccaaagatgg gcaatggatg attacatacg aaattgagta tccgccaaat 311761 gacctcttat cttccaagga cttaactcat atcttgaaat tttggaccaa aaacgataat 311821 gagacaaatt ggaatttgaa aacgaaagta ataaatccac acgggataag tgtcccaatt 311881 accaagatat tgccttcacc aagatcagtt aataatagtc aaggctgttt aacggctgac 311941 aacaacggtg gactgaaatt ttggtccttc gactctcatg agagcaactg gtgcttgaaa 312001 aaaatttctt taccaaactt taatcatttc agtaactccg tttctttagc ttggtctcaa 312061 gacgggtctc taatattcca tggtttcgat gacaagttgc aaattttaga tttcgacact 312121 tttaaaaagt ttgaatcatt ggaaaataca aagacggtca gtgagttcac gttagactct 312181 gaaatccaaa ccgtcaagtt gattaatgac acaaatttaa tagtggccac caggactaca 312241 ttaaacgcca tcaacttatt gcggggtcaa gtcataaata gttttgactt atatccgttt 312301 gttaacggag tgtataaaaa tggtcacatg gataggctta ttacttgtga cgaaaggaca 312361 ggcaacattg ccctggttat aaatcaacaa ctaactgatc tcgatggcgt accaactatc 312421 aattacaaat cccgtattat tatattcgat tctgacttat ctacaaaatt gggtaatttt 312481 acgcatcatg aatacatatc ttggattggt tggaattatg atactgattt catatttttg 312541 gacatagaat caacactagg tgttgtcgga accactgtga atactcaact atctgatgaa 312601 gttaataacg aaggaatatt ggatggcctg gtaagtaaca ccatcacaac ttcggcatcc 312661 aatagcgata tttttgcaga acaattgcat aaactgtcgt ctaggggcaa aaaaagtgac 312721 actagagata aaaataccaa tgataacgac gaagatgaag aagatatcgc tttggaattt 312781 ataaatggcg aaaagaaaga taagctagtc aatatgaata gttttacgag catgtttgac 312841 aacattcaaa acgtgcaaat ggatacattt tttgatcgtg tgatgaaagt attaacatag 312901 ctttagggtt cttccattgg atatccaaaa tagatataaa ggtatatata tatatatata 312961 tatatatatg tttataaagc aaaccgaaag caaaaatatc tgtataactt agttacaagg 313021 gaagggaaga gaatgcattg gttaatagga acagacactt cgtaaaaagc ttcacaatca 313081 ttaatgttaa tagaactatc ataatataca aaaaatctct tcatacgatt tttgtttgat 313141 gagcatcctc agtcaagatg aataaaataa tctctccaaa taagccgcct cttttttttt 313201 gaattacact tctatagcgt acatttccat gtaagaagat tgaagtttca aacaattggg 313261 tagcttaata tttgtcaaac ttcttggtag gtgttgtgtt taagaaaaag gaggcaccat 313321 aaactattaa ctttttagct tgcctcaact gtcaaccgaa tcaaatttta aaaggcgtta 313381 aacaaaaatg gcctcgtctc ttaacgagtt aaacttggtt caagtacttg aacaagcaag 313441 taacccacaa catattaggt cagatgttca aaaattagcc gaacaacaac taagacaatg 313501 ggagactcaa gcgggatttc attacttatt acagtcaatc taccttaatt tatctaattc 313561 tttacaaatt agatggttgg cggtaattca atttaagaac ggcgtggata aatactggag 313621 atccactaga attaacgcta tacctaaaga tgaaaaagcc tcgataagag gtcgtctttt 313681 tgaaatgatc gatgaacaga ataatcaact ttgtattcag aatgcccaag cttccgcaag 313741 gattgcaagg ctagattttc ccgtagagtg gccaacctta tttgaggatc tagaaaacct 313801 attgaacgat gagatcatca gaaaagattc agttaagatt tacaatatat tgatgcatat 313861 aaatcaaatc gttaaagtat taggtactgc gagaatagga aggtgccgac ccgctatgca 313921 aagtaaagtt cctttgatat taccactaat tgtcaggatt tatttacaat catttgaaga 313981 atggacgaca tcctccaatc tcaactacga ggatctttcc agtttacaag tttcttacct 314041 agctttgaaa gtgctcagaa ggataatttg tgaaggatac gaccgccctc aaaccgatca 314101 gtctgtttgc gattttatta aactatccgt ttcacacttt gagatgttaa tttcaaacca 314161 tgaaaacttc aaaaagtttg atatttacga aaagtttatc aaatgcctag gaaagttata 314221 tttcaattta gtcactggct ctccggctaa tttcatatta ctgccatgct ctacgcaaat 314281 tctaatcact tatactaggc taattttcga taaggcccct aaagtatata gagagaattc 314341 tgatgtcacg ggggactttt gggaacagac tgctattaga gggcttttaa ttttgaaaag 314401 ggtcattaat ttcattcaca aaaagggggc aattacgtta aaagcaagaa gtgataaact 314461 aaccatagat gcttctatca acaaaatcaa cacagaattt ctgaatgaga atttgataac 314521 aaggttggtt gacactttaa tggaatggta cttgaggtta agaccaactg aattagaaaa 314581 ttggtttatg gatccagaag aatggataaa cgaacaaatg gccacgagtt acgaatatca 314641 aatcagacca tgtgcagaga acgtttttca agacttaatg aatactttct ctgagctgtt 314701 ggttccctac ctgttaaaga aaattgaaaa tgatgcttca aagctatcaa actcattaga 314761 cgatttttta aggaaagacg caatttatgc aagtttccaa ttaagtgcat ccgctgttag 314821 tgaaatggta gattttgaca ggttactaat tcaggttttt ttaccagaag ctacaaatac 314881 aaacatatca ggcgacgaat taaggattat cagaagaaga gttgctttaa ttataaacga 314941 atggtctact gtgaagtgtt cggaagaatc taaaagttta tgttacaagt tatttacaaa 315001 cttcctgaca gatgaagacg acaaagttgt tttgttaacc acagtccaga ctgtcagaac 315061 catggttgat gactggaact tcaacaagga tacttttcag ccatttttaa ctgaaaatgt 315121 tcatttattg ttgaggaaaa ttttaccatc tgtgtcgtta accgagacaa ggctatatgt 315181 tttaaacacc ttgagcgata tcataattca aacaaaacct ttaattagca gggatctatt 315241 agtcgaaatt ttgcaaatca taccaaacct ttgggaaata gcaacaaata atgctagtga 315301 ggctattttg gcaaacgcat tgttaaggtt attgagaaat ttggtatcat ctttgggatc 315361 acagtcacat ttaacgtggg atatcgccat acctgtggtt gcattagcct gtgatccctc 315421 ttctatgcaa tatcagttgt taagcgaaga cgggtatgaa ctatggggca tgcttcttca 315481 aaatttttca tcccacgatc aagagtttga cgataagttc gttgaattgg tgccatttct 315541 aaagtatggt attgagacac acacagagat tctcccaact ttacttgaaa ttatcaaaag 315601 ttatgctctg attctgaatc ctgtggattt tttctctaac aacacatttc aagatatttt 315661 taaacaaatg tctaaatatc ttttaaagtt aagggaagat tcatttcagt tggttttaga 315721 aatctgggaa attttgatat tatccaatga gtcggattac gaaaatctgt tattgcaaaa 315781 attctatgaa accggagtat tatcagcatt attcgatgcc attttcctgg aagaagctcc 315841 ttcatcttat ttatgctcgc aaatcattca aatcatcgct agaatatcct acgtgaatcc 315901 agacgcctta atgacttttt tagctacata tcatgacaat ctaccaactt ctaacgaaaa 315961 tgcacgcatg ccggaatcaa taagaaaaat tgtgtctaag gatcagacgt atgattccgt 316021 tgtaaacaag cttttaaccg gatggatagt atgttttaga gatatctttg atcctaaatt 316081 caaaaaagtt cacatattag gtatttcaag tttactaagg actggtttag ttcctatttt 316141 gactgagttt tcatccatcg catctttatg gatcgaaatg ctcgaagaaa ttaatgaaac 316201 taatcgtggg gattgcgaaa aataccactt gaatgatatt gttacagagc aatcaattgc 316261 attccatcct ttaactgccg aacaattaag atatcatcaa ttatgcaaaa acaatgatcc 316321 agtgcataac attagtttaa aagattttat ttcccaatca atggaatatc tagaatcaca 316381 tttaggagta gaaaggtacc aagaattttt gaagactatt aaccctagtt tactagagaa 316441 cttacaaatg tttttatcca tccagcctca agaggctcgt ccatgatagt aataagtact 316501 aaataaaagt aaaaaattgt atatagttcg actaacaaca ttacagtggt atcttttgat 316561 cgcgcattct atacttttat tttgctacta attagatgtc gcagtttttt ttgtttgctt 316621 tttgcgtaat acaaaaacaa acgcgaaaag tgttcatgta atataatgaa gtaaaccaag 316681 tctcacggaa taaaatcacc ttcttccaat tttgtaaaag tttaaccaaa gatccaaagt 316741 ggcttgtagg aataatggat tatagtaact ttggaaacag tgccagtaaa aagtttcaag 316801 acgatactct aaacagagta agaaaagagc atgaagaagc cttaaaaaag ttgcgagaag 316861 agaacttcag ttcaaacacg tcagaattgg gaaacaagaa gcactataga gcacaggaaa 316921 ggatgagttc gccattacat agattgtctc ccacaggtaa atcagacgat aggaaagtga 316981 agagcccgct agatgataag ctaaggaggc aattaaggga aggtaatacg cgactacctc 317041 ctccaccatt ttccagctac gggatgccac ccaccaaccg atctaatttg gatagaataa 317101 gaagaaggac tagctcacca gtaagaactg ataaatttgc atcacaaaat gtgatagatg 317161 accaaagatt agaaataaaa tatttagaac gaatcgtata tgaccaaggc actgtcattg 317221 ataatctaac atcaagaata acaagactgg aatcattcat actgaattcg atctcagaca 317281 gaggagataa aaattttgcc tctctcgaac actcccgctc tttttctggg tttccgacca 317341 acaagacgta tggcttacaa atgggtggac tgtatgagaa tgatatgccc tatcgaagaa 317401 gtagcgacaa cattaataaa gaaggagcaa gagaagatcg atcgtcacaa atccatattg 317461 aaaatgaaag tacggaggat atactaaaaa tattgtcttc gtcttttcac aattgaatta 317521 agtacttaac taaataatac cagcataatc gtaactaaaa ctaaaatata gatatacgca 317581 tttcaatctt ttcttctcag agaagggtaa agctaaatga agttttcaat cggaaaactt 317641 ttaatttttg atgaatttta atttaaactt atatttcttg gaattttgtt catcgtctac 317701 agagaaaatg gggctttgat tccttctcct tggataggtg tcaccgcccc agttgtagtt 317761 accagaataa ccaatatatc cgtctcctcc tttcgttgga tcaaaatcga attgacctgc 317821 atccttaatg ttcctgaatt tgcagaccaa ttcattagat gaagacgaaa taatgtcaca 317881 aaacccttgg ttagttctca agtagtaatt cccataggga gatttaatca actcgtaatt 317941 cgctggtgta ccttgactca tccagtgtcc attcttgatt agaaagcctt gcatctgatc 318001 tccattatta atatttgata gacgaacgac tcctctgtat cttgctccct tattaggtct 318061 cctcctgaaa gttgggacat aaccttttgg aaaaaactta ataccatctt ttttacaatt 318121 tgttcgaatg gcaagtgagt ccatgggcac aaacatttcg ctcaaaaggg aacccttcaa 318181 gtggttataa taccatactt cgtttaagga attatgtcta tcacagccta tgaagacttt 318241 ttttccttca aactctttac ttagtgctgc ctctatctgc tccaaagaat aggaattgtc 318301 cacacttggg acaatattat ttttttctag tgttgaaaat gtgtccaatt tcttgaatag 318361 attataagtt attctaaaat aatcatagac cgctcttttt ctgtcaacac tattagcacc 318421 ccactcagta tagcactctg gtctaattgt gctaatgcac gtgccatgtt tattaaactc 318481 gtgtatccat aaggactcat gattcccgtt attactcttc caatataagt ctaggtattc 318541 aagcagcttt tcgcccgata tttgcaggga tgtatcatta ttattaaatt tcttgtcatg 318601 caataagtag taaacatcgt caatttgtaa ggacctatta cagaattgtt ggtagccacc 318661 atgacaatta tctggccata atccgtgaat tgtaaatgaa tctagaggcc ctaactcctt 318721 cactaattca gtttcattta aatcgttttt gcttggaaag taattccaga attgggtttg 318781 taaaaatatt ccacctggat attcaaaaca acacgagttg tctatatcag ttttattgga 318841 acatgataat ggaatgttta tagggcagtt tggttctata cccttatctg ctccattcga 318901 aaaaattggt agttgtaaga gactgtgtaa gtttttcagt aacattgaca cagtacttta 318961 gtttgaaata tcttaaatag ttggccttgc aataggtcga aagttgaagc gttaattata 319021 aattcggtag ttcccctact tttcgatagg tttgcattta agggatattt taggaaaagc 319081 ttagataccg aaattttgtt gatagagatg caaaagaaga aagaatgaaa aaggaaaaca 319141 attactgcgc aagaaagacg cgtgtgttag cgcaattgtt acgttgaatg cattgatatg 319201 taggggcata tatatgtata tatacttatt gtttcttttt caactttctt ttagcgaaat 319261 caagtacttg agaattacct tcctttgaga tgaaaaattt cttctttttg tcgtctttcc 319321 acaacaaaac accgatatct tgagcgtact tacttagtaa gttgtattct tgactagtct 319381 caaaatcaga atataaggaa ccttcatatg taatgactct atctaactct aattgccata 319441 atctgatttg atctacgacg gtaggaggca aaacttgtaa aggctcctta cagttggggt 319501 ccagctctaa ttttttttct agtttctctt ctgccaacct tctcatttga ggatgtgcat 319561 gtgtctccag ataggcaatg atttggtcgg cagtgatacc attggtcaat gctcttctta 319621 tggattccct tgttatttga cccaatacca tattcacaaa tcttgccttt aaatgaacaa 319681 aaagagacaa aacagcaatt tgcagaggtg aattagaata tgaatagatt ttgaaatttg 319741 tttctacaat caatgagcca tcgggtatat cttgattttt tagacctgct ttgttcaaat 319801 catctgatgt agtgatatct gttgtggatt tcccgttggc gccgtcttca tttactgacg 319861 gctcttctct attctgtctc agtacactat ccatcgcatt ggaggcagat ctgattgtct 319921 tggtatcgga agtcagcatc aaagctaatt ttgttggata aaaaatgcta tcatttgaat 319981 gcttctggaa taccaaacca tagtctcgca tatcttgtaa cataattctt tgtgtttcgc 320041 ttaatgcatc gattttatag gctttgccaa cttccaatgc gcctaacatg aaaataaaat 320101 gtaaaacatc gactaaatcc attttggacg tttcgatcat ttttaaatat tgcaataata 320161 atgtccataa ttgggagttg atttcttgta aaagaaattg gaagccttca ttagtgattt 320221 tgaactctcc agtagagttt acctcttcca ttagtttact gtgttttaaa aggttcagta 320281 ctttttcaga tgggatttta gcgaggggag tgccaaccat gaaatgtaat attgtttccc 320341 atttattagc tgaatattca tccaacaagt ccaggctaac tacgttttcc tctacaacca 320401 caccgaatga gttttgaact tccccacccg ttaatgcgtt cctcaggctg attttgaatg 320461 ttgggtttag gttgatcatc aaagtaccag atgatttatt tggtataaga agatgcaaag 320521 acttcatcga tttgattgca ttctgaaact gcaatttacc attagagtta acccatttat 320581 ctaaatccaa caaaggtact tcattttcgt tgaaaaccat tgccatgata aaaaatttag 320641 ctagtggtgg taaaattcta tagatagcca gacatgtagc tggtgaggta taaagcctat 320701 tttgaacttg ttgaggaatt tcttccaaat actgagtgac cgaatgcttc agggaatagt 320761 cactcattat attgttcact tcttcccttt gatggtggct tttaatgcta agttactagt 320821 attgtattct gacgatgaag ttaggttata tgtgaatata tgatggtgcg taatttgcgc 320881 tacaacaaaa aaatacattc gttttttcag taatcgcgta cctaatagaa atgcaagatg 320941 aataaacgtt ttacgcattt ttcattgtgg aaagattaag ctgtagtcaa gttttaacct 321001 agtgcatagt tcagccattc caaaatcttt cccttcgcta tcatgcagca ccttattcaa 321061 tttttccagc tccgctattt tttttttttc caactctttc agctgttcat tcatttgact 321121 ctcccactct tgtttctcaa cttctgaaag ttgtctaaag tcatcacttt cctttatttc 321181 acagatttga tcttccatac cgttgtcaat ctgatattcc aatcttctct ttttagcctc 321241 catttctttt tctagaaaat ctttatagcc gcccattcta ttgattttga ttaaagtgga 321301 atttaaaata aaagacagtt ccatctcaca aattgtcctc catttttcta tggattttct 321361 gttctcaatg atcttgtttt cgctgagaat tttacaagcc tgctgtaagt gattattttc 321421 ttgcctgaga agagtaagtt gtttcgttaa ctccctattt tttatcgcaa tttccttctg 321481 gttcgtaggc ttcttcaagt ccttaatacc gcttttaccg acccgatagt tattagtgtc 321541 cttttttgta taagaatggt tgatgcaagt attttcttct tcgttcacca aagttttgtc 321601 cttgtctagc cactcttcct gattgtgcat tactattaga taactgtaat ttggtgcttt 321661 tcctggaaag tatacttgtg atgtggaagt attttaagtt caagtttctt gttttctttc 321721 ctatttatgc ggaaggtaca tagaagtttg ggcggctaat actttttccg cggctaatcc 321781 tatagtaaaa tgatcacttt catatagaaa gttggtatat aaagtgtcaa ctaagagaga 321841 aatagttcga accaggtgta ttttaaatca actatcggga agtatggact ggtggtataa 321901 tcgaattaca tagtcctttt accttcatta gtagtactta agtgtcaccc gcctggggat 321961 tttgctctca tagaagtaaa agggtagtgc tatgggagca cattaggtag ttcagttacg 322021 ttttatggca gtcactgttt tcgcaaagac tcccagacac gggcattaaa atgaagtgcc 322081 aaacatgtca cttacccctg caactagacc catctttaga aggtcttagt ttaacccaaa 322141 gaaatttgct actttcaaat aattcaatta tcactgcaac gaatgaaaat gtcatcagca 322201 acaagggcat cgaagccgca gataattgtg ggcctcaaat accgaaggag aggctgaggc 322261 gattagggga gattcagaac ataaaagact tgaatttaaa agatgataaa ttaatcactg 322321 attcgtttgt ttttcttaat cacgatgatg atgataatgc taatattacg agtaatagca 322381 gagaggacca gcgttatgga aatgccaacg gaaatgataa taaaaaagct aatagtgata 322441 cttccgatgg aaccagtacc tttcgagatc atgacgaaga ggaacaagaa gctacggatg 322501 aggacgaaaa ccaacaaata caattgaatt ccaagacttt gtccacacaa gtcaacgcaa 322561 tgactaatgt atttaacatt ctatcttctc aaacaaacat agactttcct atctgtcagg 322621 actgctgtaa catcttgata aacagactaa aaagtgagta tgatgatgca ataaaagaga 322681 gagatactta cgctcaattt ttatcgaagt tagagagtca aaacaaagaa atatcagaaa 322741 gcaataaaga aaagcagtat tcccataatc tttcggaaaa agaaaatttg aaaaaggaag 322801 aggaaagact cttggatcaa ttattacgtt tggaaatgac agatgatgac ttagatggag 322861 aactagttcg tttacaagaa aagaaagttc aactggaaaa tgagaaactc caaaaactga 322921 gtgatcagaa tttaatggat ttaaataaca ttcaattcaa caaaaattta cagtcattaa 322981 aactgcaata cgaattatcc ttgaatcaat tagataagtt gaggaaaatc aatattttca 323041 atgctacatt caaaatctca catagcggcc cctttgccac tataaatgga ttgagattag 323101 gcagtatacc agaatcagtg gtaccttgga aggaaatcaa tgcagcactg ggccaattga 323161 ttcttttact ggctaccata aacaaaaacc tgaagataaa tttagtagac tacgaattac 323221 aaccgatggg ttcattttcc aaaatcaaga aaagaatggt taacagtgtc gaatataata 323281 attccactac gaacgctccc ggtgattggt tgattctgcc tgtctactat gatgagaatt 323341 tcaatttggg gagaatcttc cgcaaggaaa cgaagtttga taaatcatta gaaacaacat 323401 tagaaataat aagcgaaatc actcggcagc tttctacgat agcgtcatca tattcatctc 323461 aaacactcac aacaagccaa gatgaatctt caatgaataa cgcaaatgac gttgaaaata 323521 gtacttccat tctcgagcta ccctatatca tgaataagga caagattaat ggattatccg 323581 tcaaattgca tggtagcagt cccaaccttg aatggacaac ggctatgaaa tttttattaa 323641 ccaatgtaaa gtggttgtta gcgttttctt ccaatttact atccaagtca attaccttaa 323701 gccctacagt gaattacaat gataagacca tcagcggaaa ctaagtagtt catataaatg 323761 cattttttca taaatgtgat aaagggaaaa tttctttttc cacttgaaag atatgtacgt 323821 atttaagaac tgatcttctt gaccactttt tttatgcgtg caactttaaa tgctttcata 323881 catttccttg gtctttcatc agatgatatg ccagatatca acaattatag acctaatata 323941 acattgagtt attttttaca cgtataataa taactccttc tccggcaatg aatattttgc 324001 ttccaaattg caaaattcaa gatttaatta taaaaactct gaagtaatag accacctatt 324061 tcaaaaatat tccgtatttt tccctctcta taaaaacaaa gggcttccaa aatatccatt 324121 ccaataaacg gtaaactcac ccatttatga ttgggacaag agcaaaaaaa aaggaaattg 324181 ggaaaaaaaa agagaaagaa agcaacagaa taaagggaac ttgataaaac tgaagtaccg 324241 tgggtcaagt agcgtgaaag agtcaattca tcgactaatg gatgcataaa acgtatgact 324301 gtatagtact ggagtgaaaa cgaagagata aagaaaggaa aaagggagat taataaaaag 324361 aaaaaaatta aaggagttct atatttggat tagtctttta ttctttctgc ttaccaccat 324421 gaagcgttgc tatttccgta accgtttttc tcattatcat ttctaaaccc acctccaatc 324481 gaaccccaat ttgatgttcc agtattcctt ggcctcgtgc tcccaaatga gccatttcca 324541 ccatgtttac ggtagtctct tgaaccgtta ttacgactat tgaaaaaacc tcctcctccc 324601 ctagttcttc cacctcttga attctgtctt gacaggtcac ttaaaaacgt gggaacttct 324661 tgattcgctt catttaaaat ttccatcaaa cccttcacaa tattctgatt attactattg 324721 aagaatgaag tagccacgcc tgtgttacca gcacggcctg ttctaccaat tctgtgaacg 324781 tagtcatcga tgtcggaggg caaatcataa ttaatgacat gtgtgacatt cggtatatcc 324841 aaacctctcg ctgctacagc tgttgcgacc aggatatcag ctacgttagc tttgaaagca 324901 gataaggcac gttcacgttc agcctgtgtg cggtcaccat gtatggctgt agctttgaaa 324961 ttttgcatga tcaaaaaatc tgtgagttga tccgccattc ttttcgtttc aacaaaaatc 325021 aatgtcaatc ccttatgctc tgcagacagt aaatctaaca acgcagactt tttgtccatg 325081 tcatcgacat ataatattct ttgcgtgata ttttctgagg tggaaccgac tcttcctact 325141 gataaaaaaa tataattatc taagaaatcg cgtgccaaat gctggatatc tactgggaat 325201 gtggcggaaa acatcaaggt ctgtctattt tccacagagg gcatatcaca ttcttcaact 325261 atatggcgaa tttggggttc gaatcccata tctagcattc tatcagcctc atccaatacc 325321 aggtatttga tattagccaa agaaactttt ccgcgttcta ataagtcatt cagccgccct 325381 ggtgtagcca ccaataagtc acagccgcgg tcaacctccc tcatctggtt accgattggc 325441 gcgccaccat aaacaacgca tggcctaacc caagatctat acgtaaattt tcttgcttct 325501 tcaaaaattt gggtagccaa ttctctagtt ggtgcaagta ctaaagcaga tggatatccc 325561 tttctagaat aaaagctctg tgctttctcg ggtactggag agggcccaga cctgaatagc 325621 tccgtgaaga gcggaaacaa aaacccacct gtcttacctg agcccgtttg tgcgcatgcc 325681 atcaaatccc tacctttggt aactattgga atagaatatt tttgtactgg agtaggtttg 325741 gtgaaactag caagtttgat attttccatt aacagctcat ccagaggggg agaactaaaa 325801 tctagtatag gttcaggaac atcttttcca gatgcatcta cgggaatatt atcgtaatta 325861 tcaaacttta taccagatga atggtaatcg ggatcgtcgt gtacaccaaa cagttcggct 325921 tctaatttcg cgttcttagg ccccggtata tgcttgccat ttacccatct atttccagat 325981 gatttgtaat ttgagctgcc tccgcggtta tagttcgcac tcgtccctcc atttctttcc 326041 ttagaaaagc caaaaaaccc gccattgttc ccagtttgcc ttccagcacg tctgaaaaaa 326101 tcaccacccg taaccttatc ttcctgtttt ggggtacttc tttcgaatga tggttttcct 326161 ctacttctca agtgcggtgg gacataagat gatttgccgc caccaccacc attctctttg 326221 ttgttgatgc ttaaattaga taccttctgt ggcaagtctg ccattttttc ttgtaatact 326281 ttcactcaaa ggggtttttc ttaaaatatc ctttaactga cactaccgat atcttttata 326341 atcatgaata atccttgtta taaaataaag gcattacttc agagatgacc ttaagtaacc 326401 ttcccttaaa attgttaaag aactcgcggg gtaatattta cgttgacagt gatatttgtt 326461 ttgagaaatc aaagaatgaa gaacttagat gtagagttaa aggagcaata cgaataggtg 326521 ccgtgatgaa gaaaaaaaat catacagaca tttgctacaa cccttggtga gactgtttcg 326581 atcatttttc tttttctttt tctttatttt agaaaaaatt gaacgaaatg acattggcag 326641 agttgcttgg acggtcgaga atagctcaag tagctaacaa tcataaacca ttgacataca 326701 ctggcaaaaa atttcatcca acacatcaaa tcatcgaaac taagccatcg acactataca 326761 gacaagaatg ggggttgaaa tccgctattc cttcgaaaat taaatctcga tatttggtgt 326821 acaacgattt ggatacgttg gaaagaatta ccacattcga acctagaggc ggtacgcaat 326881 ggaataggct aagatttcaa gaaatgggag taccaattgt gtctaatata ggcagacaaa 326941 atccattttt caagtacata tctcgtcctg aggatgagtc tcatgctaaa ttgtccttat 327001 tcaaagaaat gaaaggagat acagatattt cgcctgctgc tatgaagaag cgtttgaaga 327061 agataacagc actaattaga tcgtttcaag atgaatttaa agagtggctg gtggaaaatc 327121 atccggatga attgaaattg aattctaata agctggaaga ctatgtagtg aagtttctaa 327181 acaaaaagtt ggaaacaaaa acgaataaaa aatttaacac tgaaatcatt ggtacaggtg 327241 gattatcata cagcttgcca ggaaagctaa aaaactcacc aaatggtgtc attcaaagga 327301 ctgtagtacc cggtagaatc ttgaacgttg ttaaggagaa caacgacaat aaatggctgg 327361 cagctattgg tgggtttgtg gccgatgtgg tatttttcca atcaccacct agttccttta 327421 actccatggg agatttcatc agaatgaaaa cgttcttgtt cgagatcttg gaggcatcta 327481 tggagaaaaa tggttctgtt tcgatgcacg ctagattact cgaaccacaa aatgacaaga 327541 ccagagaatt tttcaataag agaccaattt ataaaccatt gacctctaga agggcacgtc 327601 gaccatcagt gggaaacatt caagaggcca ataacctttt gaatataatc aagggaaatt 327661 gagaagagaa aaaaaaaatg tgaacaatca atgtatattc agagttctgt aaataaataa 327721 agaaaataaa gtttacatat tactaaggat ttttgtcgcc tatttttact atttttcagg 327781 tgaaatgaaa cgttttatat cacattttgc tatgataaca aagttattat gatttttatg 327841 tagcctatat tattgacgcg ttgttatagc attctatgaa tttgcctgtc attttccact 327901 tcagaaaggt catctaattg ctcccaccag ttgaataagt aattctcgca aataatctta 327961 aaccaaggcg taaacttgta acttgggtca gcaaacatag ttttcaaatc atttggtgaa 328021 acccatttga agtctctaac ttcattgacg tttgggttga cagtcaagtt ttctttagcg 328081 ttgatcttat aaaataggat gtaatcaatt tcatgttcac cccatggttc attgcttggt 328141 gccatgtaat ggattctgtt taaaaagtga aacttacccc ttgtcttagt ttcatcttct 328201 ggaataccta attcatgatc tagttttctc accgccgcag taatagcgcc cttaatctta 328261 tcgtctagct tacccttcaa acctaattcg tcatcaatac atagtggatg agagcagcat 328321 gtgttagtcc aaagatcagg gaaagttatt ttttcagtgg ctctttgttg taaaagtaat 328381 tcaccttgtt cattgaaaat aaagacggag aatgcacgat gtagtaaacc cttttcaata 328441 ttttccatta aatgacaaac tttcttggta ccggcaccaa tagcattatc gtcccaatcc 328501 aaaacaatac aattttcatt cattaactta atttgctcct catcatgacc agaaaaacat 328561 gtttctccgc tttcgtcatt tgacgtctca ctagatcggg tattaggtct ttgttgtaat 328621 ggaataattt caggaaactc ttccaaaatg tcttcaggtg tttggttttg cactaatttg 328681 gcgtaactag atactgcacc atggggcata ctattgttgt cggcagtcat tgaggtgtaa 328741 tgaatttttg gcttattttt actcttcctg tattccaaat acgaatactc taatattgaa 328801 ttaagtggga tatacgcctt cttgtcacta gaaaactgtt tcctgttaaa tagataaaaa 328861 tgaataaata aatataaatg gagttaagac cgaaaaagaa aggcaacccc catcgacaag 328921 aaaagagtta tgaataatca tgtttcttaa taacaattaa agggaaaaga atcggctggg 328981 catcgtcatt gcgaaactgt tgactggaaa aatttcaatc acaattaagt tttgtccatt 329041 tcgttccagc aagaacggaa acttttaccg atagcagcgg aaaaaaagaa aaaagaaaaa 329101 aaaaagaaat taatataggc aaaatagccg catgaagccc ttaataacct atactattct 329161 gtgactgtta tttatttacc ctcgtaatat taaaaatgtc ctatacaatt tctgtaataa 329221 aacctaattt ttttaggacc cttgagtgtt accctgctca tgtttttatt tttgttttag 329281 agaaatgtaa acaacagttt gggaaagttt caagaattgt aaacaactaa tcaagggata 329341 atactatttt actctttcct ttaaacatga agaactattt tttgtttacg tttttttctg 329401 aattgaacaa taagatcttg ttaatttttt tatcgcttga tctattatca gatcttctct 329461 tttgaaaaac tagtcctttt ccaaattaca aactttcttt tcgtgtggag ttgatcagtt 329521 cagtttctcc aatacttctt aagtcactga aaatataacg aaaaaaaggg ctctggaagt 329581 aaacagagaa attcgacgat ataatatgtc ttccaagcat tcagatccat tggagagatt 329641 ttataagcaa tttcaagcat ttgttcaaaa taaccctaat gtcatatcgg cagctcgagc 329701 tgccgcacaa ataccggaat ctgcaaaagc tgttgtagta ctatccccat attctttaca 329761 gcatgtgttc ccgagagaat gggtaacaaa atcgtatagg aaaactatag tcgaacgacc 329821 agaaagatta ttagcaagct cgatgggtat atcagctgcg attacaatgt atccatccct 329881 tttcaccttg aaatcctcgc atcaaaggaa aggttcattg atggcacctc atgtgcttaa 329941 agttcatggc agtagctggc cggctgagtt aattgaactt tgccaaatgg cagatgctaa 330001 attgctaaaa ggcgaaatcg aagtcccaga tacttggaac tcaggtgata tatacttgag 330061 ctcaaagaca attaaagctc tacagggaac aattggggcc attgaaactg gtgttgactc 330121 aattttcaaa ggaccatctg cagaacatat tagtaacaga gcttttgttg ctatacggcc 330181 tcctggtcat cattgccact atggtacacc atccggcttt tgtctgttaa acaatgcaca 330241 tgtagccata gaatatgcgt atgatactta caacgtcacg catgttgtcg tgcttgattt 330301 cgatctacac cacggtgatg ggacccaaga catttgctgg aaacgtgcgg gtttcaaacc 330361 tgaggaggaa cctgaagatt catcttatga tgattttggt aagaaatttg ccgaatttcc 330421 caaagtcggt tatttttcta tgcatgatat aaattcattt ccaacagagt cgggatttgc 330481 cacaaaggag aacattaaaa atgcatctac ctgtatcatg aactctcatg acctaaacat 330541 ctggaatatt cacttatcca aatggacaac cgaagaagaa ttcaatgtat tatacaggac 330601 aaaatataga actttatttg ctaaagcaga tgaatttttc aggagcgcaa aactagaaat 330661 gaatcaacaa gggagaccat tcaaaggttt ggttgtcata agcgcaggtt tcgatgcatc 330721 agaatttgag caaacttcaa tgcaaaggca tagtgtcaac gttcctacaa gtttttatac 330781 aacgttcacc aaagatgcat tgaaattagc acaaatgcac tgtcatggca aagttttgtc 330841 tctaatggag ggtggatatt ctgataaagc tatatgttct ggtgttttcg cacatttgat 330901 cggtttacaa aaccaagatt gggttaaaga atgggggtct gaacaagtcg ttaaagagat 330961 tgttcgtggt tgcaaaccgg cttggaaacc ctataagaca aaaagagcaa aagatgtcat 331021 aagaatatgg gcagaagaag ttatcaggct gggacgagca atgataccgg aattcgatga 331081 tatcattttt aaagacgcag ttaacagcgc accttctaat tctctactaa aggctactgt 331141 cgaaccagca tccacgtcga caattgctca aagaataatc agatctcata gaagcaacgc 331201 ttccccagaa aaagaacttc atgaaaacaa gccgagaagc acggaaaaac aggaacaaag 331261 ggaaattaga agcgatacca aggtcaagca gctctcgtca aataatagag cagctgaaac 331321 ccaaattccg tttttgcaac aagaattttc cagtgaggat gaagatgaag aatacgttta 331381 cgatgaagaa ttgaacaaaa ctttcaatcg cacggtggag gatattacca ttgatgatat 331441 ttctagacat ttggagacct tagaaattga aaaaaaaggt gatgaagatt cagaccatga 331501 gctaaaagaa aaaaattgga aaaactcgca ccaacgccgt ctacaaggta atggaatgta 331561 taaaattccc tccaatacga aaccgcatcg cataagacag cctcaaaacg caaatacacc 331621 aacttatgac gatagtgata tatcaatgat ttctcatgtt tcaagaaaac atacaacaag 331681 aagtggtgga agatggtgat accaatgcat atataatgtt gtcttgaacc cactaaagaa 331741 gtgacgcata tattactttt ttgtatttag taacacaatt tttctatttt tatatttcct 331801 tgtatagtta gtaattttaa tttttttcct tctttatctc agctcttcga ccatttggtc 331861 aagaagttag tttttttctc ttattttatt tgacaatata ctaattttat tatatggtat 331921 tgtaaataac atttgaggaa taaaaagaca gtcactctat aagctttatc agcctgacat 331981 ttttttatta ttacaaatat atcgttgaaa gaaagaagcc tctatacatc tcgccctctt 332041 tctatcatta aatcaatgga ggtttactgg caacgttata tttctacaat tttagaccat 332101 caaacctgag gaatatgtat atctactttc tccctttcct cttctttaac tggttcacca 332161 ccctgaaata tacacgcaaa gtcagtgatg aatggttgaa gcatactaat tggaatattt 332221 agagttgggg aaaacacgat gcataaattt cttagattca tcttattaaa cttactattc 332281 tcattgatcc ttaccagcag ttcaaaaaga gcatacatca acgataggtt agcgtgagga 332341 actaggccag attcaataag ttccttaaac cccaatgata tttgaacagg attattatga 332401 ttttcatcaa ctactctttt aaacgacaaa aattgttcgt caccaaataa taaatggggc 332461 aactttctca agtacaactt tagtaaccca cttacagtat tcacaccaat gtaaagactt 332521 ggagatgcct catcatcttt agcttcaata ctttcattgt accgacataa atctacatcg 332581 tactctttat caaacctttc ttgtaaagtt ttgataactg tactggaccc gcttagtcta 332641 aatatgcctt cttcctggat accacggttt ttgtaaagat actctaagca acgataaact 332701 acactcggta aatcgtaaac gttttggtac ttatgcgaac tcaatcttaa acacgtttct 332761 agtgacgagc caaatattgc agtggacaca tgtggacccg tagaagaatt tgacgaagag 332821 gatacttcca ttaatttttt gcttggtgac ttaatgatag agtcaggaga tgttggagaa 332881 tccgaatcat ttgaaattgt aatacctata tggttcattg cactcgccgg gccggttaat 332941 tttttaaaag ggaataaact tctcattttg gctctcctac tatccttctc ctcctctgca 333001 ttcccgcttg aacttgctag gaagttagag tgagaagatg ggtttgagtc aataccatcg 333061 ctattagcaa tgttattgct actattacta atattgttat tattattata ttcttgggtc 333121 aaatcagtga catatgatgg agtatcggtt gctgagatag ttgcgtttcc aaatttagaa 333181 tggtgtgttc ctgcgctcaa gtgagatgca gaatcagtat cgtttgcatt cctcgagcta 333241 gataacgata aactttgtga aggatcaatg taatcactaa acgcagaaag ccataattca 333301 cgttccttcg acgtttcagt acaaatataa tactttgttg aggttgacag tccgcttttc 333361 ttatgctcag tgatcaaaaa cccatttctc gttccaaatc tatcttcagg gagattgggt 333421 ataagttcta tagaagattg tctcaattta atagtttcag tcaactgatt tttgtcaaac 333481 aattgtaaaa catcatcgcg caaaataccg taccgaactc tccatgtact attacctgtt 333541 agagtctttg gtcttctcag caaaagtgat ccgtctttca cattatcatc catcattgga 333601 ggtgtcatta ctgtatctgt actaataaat tgggcgattt ttaaaccaac atttttggga 333661 aattcaggga cactgaatat gcttgtataa tactgattca atatgttctt tcgcgtatcc 333721 acttttgtag gtgataaagt ctgaaataat tgtctatcag gtaacgtggg caatggtaaa 333781 tcgggaacat gtgatttcat atatacatct aattcgcgaa ctttatgaat agattttgaa 333841 aatttaaaca tctccttacc ggatttcctg tctatgattg caattaaaat ggataaatca 333901 tcttcattat ccctgtacaa tgtgctcagt acttcaatct ggatagtgcc aaaatcctcc 333961 ggttgaacga ataatggaat atccgactta agactttggg ccacagactt cacggtgctc 334021 acgctacttg catgaggtct tctaagtgtc ttcaacgaac cttggggtgt tgagctaaat 334081 gtattcaagg tattggttga atggatggat gccgtttctc caagttgttt ttgttttgat 334141 gaactttcca cgggaggatt tggaggaaga gaagcatttt gacttgttgt tgacaatttt 334201 gtagaaagat tggggagtga tgaagttaac acaggtttct ttaaattttt tgcactttga 334261 gcaccaaaat tatcatcctt tttattcaag ataaccggag aagccaaatg gcttgataaa 334321 ggagtagagt tttttatatt tccactagaa gtaggtgaga aaaaagttgg aggcgctgga 334381 ggtgggggta aagattcgtt aatcgtggat tttatggaca gaggatcttt actgtccgta 334441 ttgactagat cctcttcgcc aaatgaggag tcaagtaatt gggtgaagtc gtcaagtttt 334501 tctttagatg ctggagagaa acccaaagcc ttgttttcac cctccttgac ttccaaaagg 334561 gatgatggac ttttggctgc tgaagtagga gttccagtag tgtatgcaga ggatgttata 334621 gaagaataaa cgcggtcatt tttttgtatc gcgtcattag ttagttgttg acttttactt 334681 tcagtcagct catctaaatt attagaggta ctggccttta atggagaatg caaatggttg 334741 ttgataacag ccgtcattct gttaggattt tgaggggaac gcaaacgttc ttgcaatgga 334801 gatttcgaac ctttattagg tgattttatg gttatcctag acgtcgtata ggtaacagag 334861 gcagctgggc tagccaactg ttctgaatgt atttttgtag ggcttgagac agatctattg 334921 ataattttgg gagatgagaa gctactattt gcttctattt catcgtttag tatcatgttc 334981 tgtaaatgct tcctacttat tgaagtattt gatgtaacac ctatttgagg tactgtaggc 335041 gttacacttg tttcaagtgc aacgtctgaa ccttgttgca atggagggga caatgtcggt 335101 attggcaaat taagactctt gatatgcgct ttcctttcag cagatcttgg gggtaacaca 335161 aatgattgat cgttaacgta tgaatctctt gagtcatttt gaacttgctc aagcacaact 335221 tctaaggaag cttctctgtt tttttgtaac atatcaataa ccttttccaa actctcaatt 335281 tcagtttcat attcttggac ttgtagcttt agcttaatgt tttccgtaaa aatttcatca 335341 taggacggat ttctttcttt tcctgaacat gttccttttt ctatatgttc tatagatttg 335401 tcctttttgg atctatgatc attgtactgc gccaacaatt caagggtggt actaccacca 335461 tgagttgtgg tcaaattatc tgtcattgcg tgctgttagt tgagtgtgag tttattctag 335521 aatatacaca cagatactcc tagcagccag tgtttcaaca aacgtgatgt tgtatatgcc 335581 tgatgtaatc acgaactcga acaaaaggca aaatggtaga aggcaaggac aaagaagaaa 335641 agagaaaaaa cttccagata caaagctaac acacaaaggt aaacggtgat taaaatggat 335701 atatcgttga tgtatttaac aatcttgaaa aattccgttt aaaaaacata ccaatacgcg 335761 caataaaaac ggttcttatc tggtacttta cctagtcaga cgattattgt tctttataaa 335821 acggccgcgt tttttttcca acatcaccgc cgccatataa ctttcgacat tcttagagtt 335881 gtggtataaa gagcaatgca tatacgtatg taatcctaat tgaaatgcta tctttgtaac 335941 ataatgaatg gttcagttga gcacatactt accatcacct ccctcgacaa atatgtcctg 336001 cacattctcg agtgtgatga gtgtctgctt tatgaccatg tcggcaactg tgctgccgat 336061 atgtggcaaa gctgtaacat cccatctgcg aagtaactct tgcttaacgc gtgtttcctc 336121 atttttaaac acatcgagac cacagcttgc cacttttcca gattcaagag cgtctagtag 336181 cacatcttca tctatgcatg tgcctctccc aacgttaact atcctgacac catctttaca 336241 ccaggccaaa cttttacgat tgataatatt gtttgtagag gccgtactgg gcaaggccaa 336301 aatgatcaaa tccgcattct tccaagtatt tggatcatct agatcagaat ggtacttagc 336361 gttgtaatca agtagactct tttggacggg accggtcctt ttgtagtatt caatgctcat 336421 gttgaacact ttgtgcaagt tagaccctat attttgtccg atggagccaa accccaatat 336481 tagaactttt ttattcattg gagattccat ttttttcccg ccaaccgtgt acttttctgc 336541 taaatgtacc actttcctat ccttgttagg cttgcatttg tctgttcgag agggaaattt 336601 catttcctga ccgtggtaac tatctgtaac aatttcatac gagtcactag agatatattt 336661 cttacactgt tcaacattac cattttccac gtatttaaaa caatattccc aaaatgaagt 336721 cattctaaag cagctaattg ctaggaaaat agccaattct gtgacatggt cagcagcatg 336781 tggtccaatg ttgcataaag tgataccttt cgatcttaat aacttaccgt caataaagtc 336841 acagccgacc catggtacaa ggattacttt taaagatgcg gggaagaatt caatataact 336901 cgaagggttt cctaacacag tgaaaaactc ctcagtgagc caaaagccgt ttattctatg 336961 agtttccaaa aatttaacaa aatcatcctt tgtggacatc tcatatttat agaattctac 337021 cctttctgcc agtttgcgat attcaggaag atgactggcg acttcccatt gggttttata 337081 aggcaccaaa attcttggtt tggcagaata agttacatct gctatgtcaa ttgaagtaat 337141 cattgttatt taaaggttgc tacttttgta cactcaagta tttttctgta tttgagagag 337201 agctatttgt actccacact ccacctttta gatctgcgtc aaagtgtcag aataaacata 337261 ccgtaaaacg gaatgactac cgccacccca atgacataaa aacggaagaa aaagagcaaa 337321 aaccgagcgc caaactatct tattcaacga atcaaataac aatacaaatg cagaggtaaa 337381 acattattcg ccacatatat atgtacatat ctatatgtat acatattttt atatatcaat 337441 cttttgaaga gcaaagtgac ctctttgttg ttatccaaag tttaaccagt ccagttaagc 337501 cggatcccag ggacagaacg gcatacgttc cctttggagt ttttaaattt agaatatctg 337561 atgtattagc catgcaatca aacgataatc ttgcaatatc taaataaaca agtgtctttt 337621 catccttgat ggcctttagt tgtttgtgta ttaacacctc tgcgtcgtta ttaacattta 337681 ggtcatttaa caactgtttc ctaattggcg attgtgagcc atcgtcttta tgggcctgat 337741 gcatcagtat gggtgagagt agtaacgcgt tattttgaac ttttagttgc acttccaatt 337801 ctaattgtct cttctgtaag ctttgcaggt tgagccaatg gtccttcaag cttaaaagaa 337861 tgtcgtattg ccatgcaaga gactcttgtc tactgacaaa ggaatagaat gatttatttg 337921 tccatatttt caatttgtat agcaagtcta attcatcaaa gataccataa tacaagtcca 337981 aaaattctct caatgaagct tcattaaacc atattttctt aatttggtca atttgaaagt 338041 tgcactttct ggttttattg aatttcccca agaaactgca cactcggaat ggtgtgccgc 338101 caaaccttaa aatatatcta aaagtactta attgttgact gataaaatca attttcttgt 338161 caaaatttct caaaagagac aggagaagta ctttaattac cgtgattgga tgccttagtg 338221 cgacttttac agtcagattt ttcaaaatct tggtatagta cgttaatacg gaagggtcca 338281 aaacagttaa atttcgctta gacttttcga taaacagttt taatatatcc agagcgtatt 338341 tgataatttt ggctaatttg tctctaccag atagagaatc caatatatat tttaagatgg 338401 taatattatc caccatcttt gtttttgctt gagaatcctc atcatcactt ctcgaggatt 338461 cagtatgcga ctcgcttcca ctgcctgcac tgaacttctc tgcaccggcg tctgatgaat 338521 gtggatgggt attgtcatcc tgggcgtcct ggtaacttgc cccagaataa ggtggtgttt 338581 ctgaaccgga aacgatatct gtcgtgccaa actgactcat tgttttacga ccagtttcta 338641 taggtgaaga cttacaggga agttgaggat atcgactcta tttgttactt tctccagcat 338701 acaaattacc gatgattctg agaagaaaga agaaaaacgt atttcaaaaa ttatataacc 338761 tgaaataata agcccaatcc caccggaatt tcatatacta tcaccgacct ggaaaaaaaa 338821 tgaagagtaa aaagaaaaaa ataaatttag cgccgctcgg tttcgatccg aggacatcag 338881 ggttatgagc cctgcgcgct tccactgcgc cacggcgctg ctaaatcatg tgagtttagc 338941 gcgtaccgag caaattcacc aaaatattta catccaattt gctcccctca ctcttccccg 339001 atgtcggttg tgattactgc tacgcatggc gactcttaat ttctttcagg tatagtaaca 339061 tttactcctt taagtaattg tctatttttc ctcgacactg tatgtagtta cctttcaagg 339121 aagctattcc aataccatcg tgagaaaaac tctattggat acttcatcta gctcgtatat 339181 atgcttttta aactttatac caaaccgtgt aggcaaaact ggaccgcccg gtaagttctg 339241 ctattaacaa attaaataaa attggccaaa ctgaggattg acagttctga atatccaaga 339301 ttactgactt caattttctc acttctcatc ataatattcc gctgattttt acataccgta 339361 tatccaattt acggcccttc acatatagcg gcgaaatgat ggtaaagcta cgcatactgt 339421 ctgacaggac cctattctag caaccttaca tgaaacaaaa acaaacaaca tcacatcata 339481 cggatgaact acgggtgcaa tccctgactc atcaatgttt atcataaact tagatatcaa 339541 cactgataaa ccccacctct atttttactg gttcttcact ttttcgatgc cgcaccgtcg 339601 cccgcgatcc ccgccctttg attgctcctt ccattaacag tttttttcta tcccttacaa 339661 gaagccgaga cgccgcgaaa atatcggcta gtgcgaatag tctctagctc ttgcccttcg 339721 caaagcaccg tgctgctaat ggcaatcaac agcgcatcgc cgctcgctga atttttcact 339781 tagcggtagc cgccgagggg tctaaagagt atataagcag agcttgcggc ccactttcta 339841 tcaagatcta agactgtttc tcttctcttg gtctgtatat gttttctcaa agttagcaga 339901 aacaacaaca acaactatat caataacaat aactactatc aagatggaaa caggacctca 339961 ttacaactac tacaaaaatc gcgaattgtc catcgttctg gctccattca gcggcggtca 340021 gggtaagctt ggtgtcgaga agggccctaa atacatgctt aagcatggtc tgcaaacaag 340081 catagaggat ttgggctggt ctacggaatt agagccctca atggacgagg cccaatttgt 340141 gggaaagttg aaaatggaga aggactccac aactgggggt tcctctgtta tgatagacgg 340201 tgtcaaggct aaaagagcag atttggttgg tgaagccacc aagttggtgt acaactccgt 340261 gtcgaaagtg gtccaggcga acagattccc cttgaccttg ggtggtgatc attcaatagc 340321 cattggtact gtatccgcgg ttttggacaa ataccccgat gctggtcttt tatggataga 340381 cgcccacgct gatataaaca ccatagaaag caccccctct ggaaacttgc acggctgtcc 340441 cgtgtcattc ctaatgggtt tgaacaagga tgtcccacat tgtcccgagt cgctcaaatg 340501 ggttccaggc aacttgagcc caaaaaagat cgcgtatatt gggttgagag atgttgatgc 340561 cggagaaaag aaaatcttga aagatctggg tatcgccgcc ttttccatgt accacgttga 340621 caaatacggc atcaacgctg tcattgaaat ggcaatgaaa gccgtgcacc cagaaacaaa 340681 cggtgaaggt cccattatgt gctcctatga cgtcgatggt gtagacccat tatacattcc 340741 tgctacaggt actccagtga gaggtgggtt gaccttgaga gaaggtcttt tcttggtgga 340801 aagattggcc gaatccggta atttaattgc gctagacgtt gttgaatgta accctgatct 340861 ggctattcat gatatccatg tttcaaacac catctctgca ggttgcgcca ttgcaaggtg 340921 tgcattgggt gaaaccttat tgtagtttat atcatcatcc cttttatcaa aataagcatt 340981 ctctttttat tttagttaag cacatgcata cataaattta cgaacaaaaa aagaaaataa 341041 attaaaaata aaagtagtgt atcttcgtta cttttcattc tttttggtta acccacgtct 341101 aattgccaat acactatcga cgatcacggc atctacacct gcttcaattt gtatactggc 341161 attttcggga tcattgttgt ccacaccgta agtgacacat accagcccat tagacttaac 341221 cacttgcacc aaccgtgggg cctttaaaat gggtgctgca gcagatacaa tccccaataa 341281 attccacttc ttagcaaatc ttataccgtt ttgtaacgat gaggctctca aatcggccat 341341 ctgttcactt ccaccttccg tcaggaacaa gatcggaata accggttgct ttaacgaaag 341401 catgatgcaa atatccggat gaaatgacga aaaaatgatg tccctaccat tcgcattgtc 341461 aaaaactact tttaacacgg tgtcaaccca atggttcatt tccatcatta tttgccctaa 341521 ctcttcctct tctgcctcat caagcatggg aaacttacat tctatgttaa acccaacgtt 341581 ggcagggatt ttcttgaata gttctttcaa ggtaacaaat gatgaagcta ttgaatgtcc 341641 tctagcgttt cccttaaaat tgttcttttt aaatgttttg gttagcctca ttcgattgtc 341701 agaccaatga gcattgttgg acttcccatt cgggtcgttg tcgtgtaaat cccaagctct 341761 cctcaatgta ctaacgtctg aatcatctac cgaacgccct ctatattttt gtagtgctgt 341821 atctgctcca tttacatgat gaggtgagtg acctgctcca cgttgaatgt gctctttatc 341881 ggcattgttc aaatctaaaa actgttccag cgtcaattca tgcatgggga tatcgacacc 341941 tgtttcagct acgagaaaat cgtgatatac cactggtacg ttatccttcg tcaactgaac 342001 atcaaactct acatacgatg ctcccaatga ggctgccatg atgaaagact cgactgtgtt 342061 ctctccaatt tgtaatgatt tattaggatt atttttaccc aggcctctat gtcctataac 342121 acgagtggac actaaggatt tccagtacgt ttctgttctt tctaagggca gttgtggatg 342181 ttcaaatggt gtgataataa tatattcaaa tttcagcgtc ccaagtatct ccagtgtatg 342241 attagcgatg atggggaccg tcacgctacc atttaatata cttctattaa ctcccactga 342301 gctgtacgac ttattcaaca tggaaacacc ccttgccatt acgtaattat tgttattttt 342361 ttgacaatct attctattat gggtctccaa cgagcgtgtt ccatatgttg gcacaatatc 342421 aaaatataat gtatgagaat aatcaacttt gaaaggcact ttgaagtcta ctgcgtccac 342481 attatcatct aatggtaaat ctaagattac agaagattta tcaattgaat cattgcatga 342541 aattactaac gataatgcac aatctgtttc caacccaata acttttgcta gtgcttccga 342601 gcttaatgaa attgaagggc ttttgtttct tgtgtcatta cttcccaatg ttattagtat 342661 aagtgattca ttattatcca ggaatctgtg tccatatgac tttattggtc cggccagttt 342721 tcccaaggac cctttattac ctccgtttcc attttcattt ctctcattta attctccggc 342781 actaatttcg tttagtggtt ctttctcttc gctaccactg ttcaactgtg aatggggatg 342841 cgtgaccagt tcgtctctga tttgaaccat atcagcaatg tgcaaatgac cgcgcaatac 342901 cgcgtgctcc atcggcgtcc acccaccttc atcttcaata tcaaagttcg cgttgttggc 342961 tatcaagagc tttacaatgt ccgtaaaccc ttctgctgct gcaacgaaga tagctgtcca 343021 gccaaaaagt ttttctctta tttcaaggtc ggctccattg tacaacaaac acacagcagc 343081 ttcgaaaaaa tttaatctac aagcaagata tagcggtgtt tcatgtaatt cgttgtcttg 343141 ataattaata tcaaaccttt ttgatgatag gagaacatgt aaaaggggat agttattcca 343201 ctcagtggcc aaatgtaaca aacttgaact ttttaatttc acgttcggat ccaaagattg 343261 caataagact tctgttgttt tgggatgagc acccaacaca cataaatgta aaggtgtcaa 343321 tgattcggca tctccgaacg cggaaacgtc atcaataggg atttcattcc agatattcca 343381 ttctttcatt aacttgataa tcaacttcgt aacttcagat aagccatact ggcaagaata 343441 atgcaagggc gttctcttgt aattatcatg ctgaaaaagg catggtctta aatgaattgg 343501 taactcctct aaaatataag agagtgtaca ggccgaactt ttttcctcct ctgtaatgct 343561 atctgattct gccggggcag atagggtcgt atgcagggtt cttaaatctg ttacaatttc 343621 tccctcacta ttagtatatt ttgagggttg tgacttcttt ttcctactta aaatttcctg 343681 ttttctgatt aacttcccga ttgcaattat gtgatgatgg aaaaaatttc ttctgttaat 343741 atcttccgag tcatttagag acggaataac ctttaagata gcatcaatac atgccagtga 343801 tttagacagt gctgccttgt ttaaaacact tatcataatt cttgttggaa tcaaagacaa 343861 ttccgaatat aggtttgtta gctctctaat caatcctttg ctatcatctt cttctataaa 343921 aacgcaaata atcttaaaga attctgtatt atcattagca tttgcgttcg gcgaggtact 343981 cctcattact ctctcgtaag aatttatcct gaacgtcact tgttcccaga tagtttttag 344041 caaactcaaa tctttggtaa taagagaatc attagcaaat tgtaacggca agattctagt 344101 tttcatagtt gacatttgct gatttgtgcc gactttttta tccagtttct ttaaaatctt 344161 accaaaagct ctcttattta gttcagcgta ccactttaag tttctaaatt gttttcttaa 344221 ctcagctaag atagactgaa tttcaattaa gtcatcttta tggtaagata gacggctggc 344281 ttgacttgtt ccctttaaaa gcatattcat ctctctcgta tcctttgtga gtaaggtttg 344341 cgctactgca tcttctttgt tggcatcgac cactaatgtt gattttatct cattgaattg 344401 attagaagaa agcaatctct caaatctttt cttatattcc gcatactggg aattgtaaaa 344461 tgtatcaacc ttctcaatat ccctgtcaac tgcaaagaaa aacgacgcca ataacttttg 344521 gatttttgga gagtccaaat aattttgagc actattagat gaatctctca tttttgttgg 344581 tggcctgcct tcatcatagc tattcttgtt atgtgcccta tatatgtctt cttgaagtct 344641 tgtaatttct ttaatcattt tcttcaacga cttgtagcca acatattgac ttgaccactc 344701 tggaatgcga tgattggcaa aggtttttcc gaacttcatt gattatattg tttgattata 344761 taaagacctt acagtttcag tagtttgtca ccttagttgg agatagtggc tatttttgtg 344821 taatttgatg agggttccct tcttagttgg gtttaaattt tttgctaccg ttgccttatt 344881 gttcaatgaa gcactaattg caaaacttaa actctttaat agtctcactt tgtaagacaa 344941 taatttattt tttacttctg tcagccaacg ctctcttttt aatataatgt gcacgttcta 345001 aaaataattc tcttattcag ttggcgctat taagtgaatt agaaacgttt tgacgaaatt 345061 tactattaaa agaacactac gagtcgataa tgacagcact ggtctaaatt tcagctagag 345121 caacagcaaa ttattatttg tcacttaaat aaacttggtc gtttttttgg agagctaata 345181 tgttgggaca gcgtgtgtaa cattgctcca cctgcgaaca cgtggaagtc gcaattataa 345241 aagatgcata aaaagaaaga atattaataa ttaggacaca attgatcagt cctgacaaga 345301 tcgtatattt gcttcatcga gagatgcatt aattgacgca cttctaaacc aacccatatc 345361 ttgagcattg ataatgtgct tgcatctttc aagagacttt tggcttcccg cttaaacccg 345421 aattcacgta atataggcag cgaactgttt acgaagagaa gttacaagat gtgggtattt 345481 ttgttagtaa aagaatttct ttagtagcaa taaaaagcaa aaaaaagcaa tagaaaaggg 345541 ttttaaaaaa ttgatgttat tctttaaaac cgttaatcca tgcgtaaaat acgaaccttt 345601 caaataagtc caagtttgga tctaactggc gtccaatacc ctctagaagt aaaatagcga 345661 ccaccacgga aacaaagtcg gactccattc taacatggtg cgaccttacc atactaagca 345721 tttgatcgag taaatcgcca attgagacgg ttcccaatgt aaatgttctt tgtttaactt 345781 tatccactag cttttctacc ttaaacgcaa atacttcctt atcaatagct gtttctggag 345841 ttcttgatct ctcaatcatc aactcaccag ctctataacc atcaaatcgg gccaatgcgt 345901 tgaatagagc tatgaaatta attctgtttt tttcattcaa ttctgtaatt attcctgtat 345961 cgataaaaca aatttgggga gtgtaattag ttaatacaga cttcagtttt ccaacaaagt 346021 cctgatcttg gtcctcctct atcttcttcc tcaggtcgtg cgttattctg tacgattcaa 346081 gttcggagga tataatgttt gtgccgtatt tgttcgtctt cacaaatctg attataacat 346141 tgcctggatg caaatcagca tgaacaaaat catcaagaat tagcatttgt agaaacgcgt 346201 caacgaaggg atcactgact tttttacaaa gttcaacgtc gttaatttgc ttcttcgtag 346261 ataaaaactt ttccatggaa agaccatata catgctcttc gaacataaca tccctatttg 346321 acaaggggag aaatggttta ggaaatttca cctgaataga atttttaaag ttctcattga 346381 atctttccag gtttaacgcc tcaattctta gatccaactg aatattcatt aatatggaaa 346441 actgatcgac ttcgctgggt aaagacagcc attccatagt cggaatccaa tttattgcgt 346501 cagcacagaa tttcattatt ttcaaatctc tccggatctg agatcttaca tttggatgca 346561 agatcttgat ggcacaccaa cgatttccat ccttaccaat ttgtatattg tcatatttat 346621 cgatgtactt ttgggatagt tcacccacgt aaacttgtgc gatggaccca actccaattg 346681 gtgttcgatt aaattcatca aaagcatctt cgatcttgtc aacctttaat gcttgagaaa 346741 gtttttccag agtaaagctt agagagtgag ctgtaacgtt actatgcaat ttacccaact 346801 catgacacag tgcgtgagag aatatatcgg ttctcgatcc tgcccattgt ccgagtttaa 346861 tgaaactcgg gccagccaat tccaatgctt tacgcagtag ttgacaccaa atcaatgaac 346921 ctcgagtttc agttatattg gtgtccgtaa ttttgagttt atgaccaaac catgatatgg 346981 ggtataatag gagaagaggt aaaaaaatag ctgaaatttc taaaaacctt aaaatcgtgc 347041 atacaggctc aacaatatta tcattaaaac cgaaccaaaa gattcttaga tatcttatta 347101 atttatttcg tgattcagtg atcttagcag acctgaaaga tttaagcttt tcctgcaatt 347161 cgttttctga ggaaacgtag aggcccattt caaaagtatc acctttggga tccggtttta 347221 gagaatcatt gtatatcaaa caattttgtt ttggaaacga attttgtgtc aaataaaaag 347281 caattgacgt aggtattatg aactgtctta taggtatttt atgaaaatgc cgtgtggact 347341 tgctatagta tcgccaagag tttctataag cgaactttaa aaatgacatt gcccagatgg 347401 ttctgatgtt ctttatctct attctgtgag ggtttgatat tgatgagtag gtagaagata 347461 tggtataagg tattttctat aacatcaaac atcttttctt tttcatcaaa tgagtgaaaa 347521 ggtattattg cccctcatat attcggggtt atttattttt cgttgcttga agtaaagcct 347581 ttaatacaca cttagtattt aaacacttaa gatttacgaa tcacagattc taaatttgta 347641 tttaataaat tgattctaag tacaggaagt atcaaggggg ggggttgaca gatagaatca 347701 caccttgatt aatttagttc ctgatgaaca agccaacttg accaatcaaa ccctttcgcg 347761 gcactttttc tcttagctct gcttgataca tcgactggga acttcttctc tttgagccaa 347821 ctaacctcaa tcccttaaag attttgtaaa ccgcagaaac acctggttgt tttcgcttgt 347881 tggcaaaggt taataacaca gtaactttca atcttgttcc gaagtgcaga gtgcagttcc 347941 ctgtgtgttc aagtgacata cggcatttga atacactaca cttatcgtca tgtcaaaaca 348001 agtgttatag aagcagcgtt aatataatat tagtacctgt acagttttaa actcaattga 348061 gtgcaaagat ctgatgcatc ccattttagt ttctcataaa ttattgcttt ggttcatagt 348121 tcaattgtaa gcattattaa aacaactgct tctatttaga caatacaaga acgcgatctt 348181 tccagtaact gcctaatctg aaattatgtt tttcagttgc gcctgtggcc tacacaactt 348241 gcataataag cagttaaaaa taactcctaa tcttactaat cttgtcgaac tagactagct 348301 gtaatgatct gtcatatata agttaatatt caacatcgac tgtaattgtc aattcaatct 348361 tgacagcaac gattgaagtc atcgcctcgc cgtaattgaa aaaaaaatgt aagatgaata 348421 acagctaaga aagataataa tttttatgaa agaagcatct gatagagaag aagcaccaaa 348481 aatggtggaa aaaaactata gtacaggttt taggaaagcc cacggagaga aggatcaatc 348541 agtgactaag ccaatctcgt tagatggtag aacaggtgaa gtaattgtta gaaaatccac 348601 cgggaaaact aaaatacgta aaggtcaaac ggaagaagag tatacacagc aattgcagca 348661 ctacttcgaa gtagaacaag gccctgtgcg gacaaaggta ggatggatgg atgaggtaga 348721 tcccttggtt gagatccggg aaggcaagta cgatatctcc aataagcatc agcgacaggt 348781 gcttagtggt ttctgccatc gtttatttta ccaatgtaag tacaaggagt gtctggatct 348841 cagcacctat tttctggggc tctttgaacc gttcaacgtg aagaataaaa tgaagaggga 348901 gcttgaagag ttggaatata tgatcgagcg atgtcgtggg catgtattat aagcccgaat 348961 cagatactca aatttgaaaa aagatatctt tctcctccga catggccgaa ctcatttaca 349021 taaatagcat aaattaaaca gaataataat acgtaaatta caacagtcag agggtgcatg 349081 aaaccgtcat tagatagaga cgtgatcaaa agtagaaaat gataagaaat cagggatggt 349141 cattacttta cagaatttat ccggtgcgga ggttcacaag atactccaga gtagatatga 349201 cttttgaagg aaacactcaa gatatctcta cttctgtcga agaaagaatg accactgttt 349261 ttggaggacg cttaaagggt gaaccaccaa gatccacaag tagagtgctt agcggcggaa 349321 cgaagaaaat agcaggtgtc caagtgcctg caaaaccaca agaacccgat aactgttgca 349381 tgtcaggttg cgttaactgt gtctgggaga tatatagcga ggatttaaga gactggaaac 349441 atagaaggaa agaggctgcg gaaaagatcg caggaactaa ggagaagtgg cctaaagact 349501 ggaatccacc tttgggattg ttacatatgg aaaatgtccc tgttgagtta cgtgaaaaga 349561 agctggaaac cgatagcaaa aaagcagaac aacctcatga tttatctgct atcagaagtt 349621 tgttccctaa aagaaaaggg cctctgccca agagtgtatt ggcagccaag aggaaaaata 349681 ttgctttgag acacaattac gaacagaaag atggaggaga ccaatcagtc agtgaatcag 349741 atgctgatga aggctgggaa gatattcctg tctacgttaa agcctttgca gagtttgaat 349801 caaagaaaag attacaaaaa attcgccgac aggaagaaat aaaaaagagg acagctttgg 349861 tttgaagcaa atatatatta ttgaaaagcc tatgtacaat atttgcggtc ttctttgatc 349921 ttggtagact ttatggatgg agaataataa acatacatat atttcactta gagggtttag 349981 gagactaatg cgtgaatacg cgctggcatg tccccattca tgcatacata tattcgtaaa 350041 catacacata ttcataaaaa ttttcagtta tattatatta taatcttttt ttaactatac 350101 agagaagata ttaaaaaaaa tgtatccaaa gtgagttaaa aaaatcggaa aaaacaataa 350161 agatcctttt ctagttactt tgctgcatta acattagtcc atgtcaacat caccttcagt 350221 gtccttcttt tcttccttct tttcagcttc tgcctttctt tgagcagcca acttttcagc 350281 catagcagcc atttgggatg cttcttgctt agatcttata gcttgcttct tttcttcttc 350341 tttagccaag tatctacctc taataatgtt acctagagaa gccaattctt cgtatttggc 350401 aatgtactta gctttgatgg aatcgaaacc ttcatcgtat aaccactctt cggccttgtt 350461 taacatacct tgtaacttcg tcttttcagc atcggaagca aatggagcat actcttcttc 350521 caacttacca cgcaatgtgt agatgtactc ttcaagagtg ttcttacggt cttctgtctc 350581 agcaactagc ttatcttgag caagcatttc attttctttt tcaattaatt cattcaactt 350641 tttagcgtct aggccaaagg tgtgtgcaac gatggttaag tcatccttct ttacagtttt 350701 agtaaccttc ttaaattctt gctcagcatc ttctggagca tcttctggta atggaatagg 350761 ttcttcaact tcaatatctt caatagtgta agcctcttca attgtgtgta aaccagaggg 350821 gtcgcatctc aactttaact taacaggaac agagtcttga ccttctggta attgaacacc 350881 agtgatctcc cagttagcga tttgttctgg agtgtttggt ggtaactgtg tgatgtcagt 350941 gtagctagca gccattgaaa agtcacccgt acggttcaaa gtgatcaatt tagtagatgg 351001 gaaggatgaa ccagctggga aaacttccat gtggtcttcg tcctcaactt gcttgtccca 351061 agagtaagag acagagtaag gatggatatc ctcaaacttg aatggtctaa ctcttagagt 351121 tggagagtga atggcgcaaa taaaggcggc acccttggcg atggcttcat cttggttcaa 351181 agtggtggac aatggcttgc cgaaggcttc agaaatggat tgtttcaatg ttgggatacg 351241 agtagtacca ccaataattt caacaaaatc aacttcttca gcagataatt tggcttgagc 351301 taaagctttg gtaactggtt cagtaacacg ttccaacaat ggcttgacca attcttctaa 351361 ttcttcacga gataattgag aggaaacatc aacgtcgttc atgacggatt caacagagaa 351421 tggggcatta gtattagcag acaaaacttt cttcaacttt tcagcagcag ttagaattct 351481 gttgtaagcc tttggatttt ctctgatgtc aatcttgtat ttagttttga actcatcggc 351541 gaaatgttct gttatagcca aatcgaagtc cctaccacca aaatgcttgt cgcaggcagt 351601 tcctaagact ttcaattgac ccttcttgaa ggccatgata gaacaggtgt aggaagagtg 351661 accaatatca acaaaggcaa caattcttgg cttttcttcg ccttcaggca aatcagtctt 351721 gaagataccg taagaaacac cggcagcagt aacgtcgttg acaattctaa cagggttcaa 351781 accagcaatt ctagcagcat cagcaatgtt gtaacgttgt tcttcggtgt accaaggtgg 351841 gacagcaata caaacatcgg taatatttgc ctttgtgtcc tgcttgacgg tgtccttgac 351901 tttgtcgatg aacatggcag ctagttgagt agctgaaaaa acatgtttct caccagcgaa 351961 tctaacttcg gcaccagtct tcttgtcatc caattcaacc aacttagagg tgaagtgctt 352021 agattcttgc tcgaaatctg gatggtggta atccaaacca ataattcttt tcaagttggc 352081 gacagtgttc ttgatgttgg aagtctgctt gttcttacca gtttcaccca agtatctgtt 352141 ctttggacca aaaccaacaa cagatggggt ggaacggtta gagacttcat taacgacaat 352201 gtcgatacct ctgtttctag caacggcaag gacagagtta ttgttaccta aatctaaacc 352261 aaatggagta ctcatctttt aaagaaatgt tgtttgtcaa tgtacttttt gcttatggct 352321 atcgaggtta aaaataagaa tcagaactaa ctgagttata agaagaaaaa tcaagacaga 352381 gggagtttaa aatggacagt aacttttatc actaaggtta tattgacaag tagtgctctt 352441 tggaaaagga atcttctaga atcatcttcg ttaaatttct tttttcattg ccttcgaaaa 352501 aaaaaaagaa aaaaagaaaa gaaatacacg taacaaatga ttatgcgctc aaccaactta 352561 aacacttctc atctccatta agaaccttca aacagacgat agattcgcta aatgatacgt 352621 tctgcaattt gaaaaatgtg cttacctttc tcaattcatg tggcttcaaa catttaatcg 352681 atatactagc tataggtagt ttgcacacgc taacatatta ttgtagcgtt cttagtactg 352741 ttattagtta tcaagatatt taatttcaat taattataca aatagatggg agttatacta 352801 gttaatacat tgaatagaag atatacacgc gtagtaaaca actactatgg aacaaaaagg 352861 cttcaaaatc tttttccttt ctttttacca acaacttgaa attcccagtc ttcggaactg 352921 ccttcaggca tagctaatac ttcactccag ctcaaggggt cattaatttc ttcttcgcat 352981 tctagacgtt ttttgatgaa atcagtggca aatctcctac cgtccattgt tgaactgtag 353041 gaatatatgg tatctgcgat aatttccttg gattctgaac ctgggggcaa gctaagtagc 353101 atttctaaaa cattatcggg ctgaacaccc gtatttagtt ttaattggga tcggcaccat 353161 ctcaaaaatt cttgacgctt agagacagaa gcgttaccgg gataggcagg gatgcgagac 353221 ggtttaactt gacgggcctt taaagtcggg atactagtgg atgagccaat ttgtttactc 353281 ttatcgctca ttttagtttt tgttgcggta gataaccccc cagaagaacg cagtgtgtcc 353341 aaactgatat atgactttga ctggttacca gcgacaggca tggtggaagc gatgtgggtt 353401 gtgctcttag aagaaaccgt ggtccacgca ttgctagtat tcgaagagtt caatgccgaa 353461 gaagatgggg aaggcgttct tgaaatgaaa tcatcgagtg aagaagcgcg gttgaatttc 353521 tttgttttct tttgaacttg ttcccacagc tttttctgct cttcaataaa agtggaatct 353581 ggtttaatat caccattgtt ggccttgtta attttagact gactgttaat tttggtactg 353641 tctttcatca attctccttt aatatcaact ttgatcggtt gctgtggctt tataccccag 353701 gcagaaccag tttgagtttt cggaatttgc gccgagctta atatttcttt ctgtagtttt 353761 aatgcctgct cacgatctaa ctgagtacga ttaggttttt tttctttctt ggacgagttc 353821 tccttcttca aatcttcaag agcagatgaa atctgattat aaacagcacc ctcgggtttc 353881 ttgttagccc aaggcgccaa attagtggtt atggaagttg cggtgttttc ggaagatgga 353941 gtttctgtat ctccagttaa aatgttattt agcaattctt tttgcttttc tttctctaat 354001 tttccttctt ccttcttctt cttttttaac ttctcttctt cctttttctg cttttgcttc 354061 aattttttct ccttctttaa tttgcgctgt tcttctcttc tctttttttc ttcttcttgt 354121 ctttgttgtt cttccaataa tttttgtgcc atcagttctg cctttgcaaa ccttttctgc 354181 tcttcagaag tcatttgcgg cgtatctttg cttttcggct catcagcagt ggatattaca 354241 tccttacggt ctacctcttc aatctctggt tgaacttgat ccaatatatt ttgctctttc 354301 tcgcttcctc gagattcttc ctcctgctta gtaggatttt tgacaataga ttcctcttca 354361 tttgttatgt tagaaacagt tctgccctct tctgaaaaaa cctcttgctc ctctggagaa 354421 gcttcctcgt gggaaggaac cttctcttca tgggaagaag tggttttatt agatctacta 354481 gaagtcgtgg atagaggagc ggtatatgca gatatctttg gtatgcgatc tacctttgtg 354541 atatgacggc cgtcaaccgg aacccaaacc tgagtttcat gatagtaact tccatcttca 354601 aatttaaggc caaggatttc ttcatacgta aaatcatcac tatgcacatc agcaacaggt 354661 atcaaatctc ttgactcaac tttttgcttt tctgatgaag ttggtgcaac aagtggaaca 354721 gcattcaaag ctctaataac aatgaaatca aaggcgacaa aagggtcttg ataattattc 354781 accagagtag tcaattcacc tagtctaata aaccgatcat ttacaccaaa tggctcagga 354841 gatgttgcta atctacagat ttgcaaagtt ggagtaaaat aacctccttg ataccactgt 354901 gacatattat tggtaccaaa aggcccctga atgttaccat tagagtcaat gtatttccac 354961 tgagattcta tccccggtgg tgggggttga ttaccaacgt tgggggcagg ccctgttgcg 355021 ttgtagagat aaggagctac atttggaaat gtgctcgagg gtttattgag aacggaaggg 355081 ctgctggcgt tcatatgcag gttggatgat gctgcactaa atgcactatt gttttcctga 355141 ttagcagata tttgtagcgg agatccagta atttcagcgt catatgcatt gaagggaaca 355201 gtactggctc cactaatcgc attactccct ggcacaaaag gagatggaac tctttggacg 355261 ccaatagaat ccataatgga ggagggcctt tgcaaaagag ccgcattgtt catggttgga 355321 gtattgctat ttgataatgc agcagtgtct gagttcgcgt ctgcaagttt aacactgtga 355381 aggtcaaacg ctagagagtt gataggattc atcacttact gccactgcca atcttgtgca 355441 agctgtggca aaatcgacct tctccatgcg tccatggtaa atgaaatgtt ttgctttctt 355501 tttcgtgctt gcaaagtttg gtagatgaaa tttcagaaag ctactgccgt accaaagtac 355561 aataataagg tgaaaatggg agtaggaagt aatagatggc attgaatgcc tcatttattc 355621 attattcatg ttttcttaac attttgattc agttgagtgc atgctttttt gaaaagacta 355681 aacattacaa gttttaatca tgttggcccg ttccagggtg tgcttgcaga caatcactag 355741 acggttggca gactttccag aagccaatgc tattaagaaa aaatttctct ttaggaagga 355801 cacctcgacc atcaaacagt taaaaggact gtctagcggc cagaaaatag tactcaatgg 355861 atggatagag cagaagccaa aaagagttgg gaaaaatttg atcttcggac ttttaaggga 355921 ctctaacggt gacattatcc agttggttga taacaaatcg ttgttgaaag gctttacttt 355981 agaggatgtg gttcaagccg taggtatact ctctttgaag aggaagctat caaatgagga 356041 cgcagatgag tacgaagtgc aattggagga tattactgtg ttaaatgcat ctaataaaaa 356101 accagcgcaa atgcaggatt ttaaattgtc agccatatac ccacctgagt tccgctattt 356161 gcaattgaga aatcccaaat atcaagattt tttaaagaag aggtcatcta tctctaagga 356221 aataagaaac tccttcaaca attttgattt tacggaggtc gagaccccaa tgttatttaa 356281 agctacccca gaaggcgcaa gagagtttct ggttccaaca aggacaaaga gatccgatgg 356341 taaaccatcg ttttatgctc tagatcagag ccctcaacaa tacaagcaac tcttaatggc 356401 tagtggtgtc aacaaatatt atcaaatggc aaggtgcttt agagatgaag atttaagagc 356461 agacaggcag cctgagttta cacaggttga tatggaaatg gcctttgcta attctgaaga 356521 tgtcatgaaa atcatagaaa agacagtttc tggggtatgg agtaaatttt ccaaaaaacg 356581 aggattattg actttagaca gtaagggtac attagtgcct gcgaaaaagg aaaacggcac 356641 agtatctatc tttcgtatga cctacgaaca agccatgacc tcatatggta ttgacaagcc 356701 agatttgaga gcgccagatt tgaagattat caatttaggc gagttcaatg cctttagtca 356761 tttgaacaaa aaatttcccg tttttgaagt aattattcta agaagtgcct tttcaaatat 356821 ggaagagtac aaagaacgat ggtcgtttct gacaaataac agtaattaca attatagagt 356881 tccaatagtg ctaccaattg aaaatgacga acaagctaat tcaaattggt ttgagaattt 356941 tcatgcaatt gccacgtttg aaaacccaca tctaataacc aaatttctga aactgaaaaa 357001 aggtgacatt gtatgcggtt gtacgagaga gccaaaccat tccattttcg agaatcctac 357061 tcccctggga agattgagac agttggtgct acaaagtgag catgggaaaa atatctatca 357121 tgctgtcaat aaggatgttg cctcatggat tgtggatttc ccgttatttt ctcccgttat 357181 aattgaagat aagtctggta aaaaagaaaa gcttgcatat ccggagtacg aaaaggatag 357241 actatgttcc acgcatcatc cttttactat ggtgaagctt aaagactacg aaaaattaga 357301 aaagacgccg gaaaagtgct tgggtcggca ttatgacctc gtagttaacg gtgtggaact 357361 tggtggtggc tcaacaagaa ttcacgatcc aagattacaa gactatattt tcgaagatat 357421 cctcaaaata gataatgcat atgaactatt tggccattta ctgaatgctt ttgatatggg 357481 aacaccgcca cacgctggat ttgctattgg ttttgatcgt atgtgcgcta tgatctgtga 357541 aactgagagt ataagggacg taatcgcctt cccaaaaagt attaccgggg ctgatttggt 357601 tgtcaagagt ccaagtgtga tacctgaaag cattctggaa ccttacaata tcaagtatag 357661 taattcaaaa aaatgagcag aagttgatgt tacctagatg tgagagaatc ttagtgtggc 357721 tgcagtatgt aggtttttct tgtaaatatt atacctattt tgtttgcctt gtatatgaag 357781 agatgaaata acaaatcgat atccattact tgaattgatt ttttatcaac attaattgta 357841 atttctttat aacatcttat tggatatcat acgaatgttt ttaaattaca aaatcattaa 357901 atcataaaat gttcagtgag tacaatctcc caaagtctac gtttactgta atttatcgct 357961 atttacaggg acgctgcagc ttaaatatta gcgcctaagt tagtcgaagc attctgtctt 358021 gcccaattct ggacagtagc agcggtcttt aaacccaccc cactcggcca acatttctaa 358081 tttttccttt ggctctaaga aatattctcc gcttaataca aaggtccccc aatgaacgcc 358141 taatacattt cgagcttcta gatctttcat aatcttgaga acctcttgag gattaatatg 358201 tcgtggtttt tggtgccact cagggcaata ctgaccacat ggaagcagcg ctaatttaca 358261 acctttgcca aagcgttctt taattctaac gaataaatct ttcacatatc cagtgtcacc 358321 agcatgaaaa agtatgggat taccatggtg tgttaataaa aaggagcacc atagagactt 358381 gttcgtatct aagagcgatc tcccagacca atgcatggca ggagtagccg atatgtggta 358441 tatctcattg tttttcttta cttgcaaagt ttcccaccaa gataattcta ggacattatc 358501 acagccgtta cttgtcatat aagatttcat tcctttaggt actatccata agggagagtc 358561 tttgccactc cagtattcca agctttctaa atccaggtga tcggggtgat tatgggatac 358621 aaggatgata tctggtttgg gcacctctgt aatttgagat ggcatttgag taattctttt 358681 aggacccagg gtcttgtgga taagaaagtc actgaacaga ggatcagtaa gtatcctcaa 358741 tccattataa accgtgtagt tacaggactg gcccagccat gtgttataga ctgggcactt 358801 tgatccttca ttttcttcta ctgcagtcgg tatgtgcaat tcgtctaaca ctttgcattc 358861 tagcggcaat gccgtttcct ctgcggggtc gacgtccact aagttaggcc cccatgttgg 358921 cttgtgtaca ggcattaact tattcatttg gtgtacatca cgtggaatac ctcccctatt 358981 tctttcaaat aattcgaaca ctctatttgc aaagaattca aaaacggtct gaatcctgta 359041 ttcttcgaac gggttctcaa atctgcctaa aacttccaaa gggctatatt ttagcaagga 359101 tcccttataa gtgacctcgt tattattctc ctctaatctt tgacacattt cgtttcttaa 359161 atcaatttgc ttcactgtag ccaatgatac ataaaacgca tatcctgtgt aaggtaccaa 359221 aacagacaac agaagtatac gtgcgtattt tctcgagcat ttttgtatag ggcgtgtctt 359281 ttgcgaagca tgtcttttga aagttgacaa tgatgtctgg ggtctaaaca gctctgattc 359341 tcgtaaacgc actagtctcc tttggagaag aagcctcatc tgaacatggc aggtaacaaa 359401 attcatttgc aacacaagca ggcatgcaat ccttcagtaa ttggagtgct actgttcaca 359461 ccatattctc gctattctcg aactacgttt tttttttttt gttaagcatc agtagtgagt 359521 cttcgggaac tgcttaacga cagtaaagga aaaaaaaaac tagcagctgt tgataatatt 359581 cagaaaatga acgcagaagg aatcattagc taaaaagttt attattaaaa tcagacatat 359641 atctcattat aatatttttt ttttataata ccaccatttg ttctcatata atactgataa 359701 atatcgcatc gaatggaaaa gacaaatagg aggccgctat tgtaatttgg gccttaacct 359761 atttattctc tctcttttaa ttgatatttt aatctttttg aagcctacaa tgtattttgg 359821 gcgataatca aggagaatat cagtgtcata tactcactgt ggtaaatgta tttctaaagt 359881 agttccaatt ctttcttcaa aaaaggccac tagacgatgt gctttcttgc acaagcattt 359941 tgctgggcta tcttcaatag tgataattct aactaactca aaaccagatg gcaagttctt 360001 ccctatggtc gacttctctc agacgcaata gtagctatgt tattgatggc ttttgacgcc 360061 agaccgggta aagcgcatgg aatgaactct aaactgttaa aataacaaaa acgacatatg 360121 aagatgtcga tgaggctgga tagtttagag atgaggtgca gagaacaaca ttgtataaca 360181 aattcggctc ccaaatatcg catgtaccat gtcatttcgt aaaagaggtg aaatactgaa 360241 cgatagaggt agcgggctaa gaggtccact gttaagaggt cctccacgaa cttcctcaac 360301 gccattgagg acaggcaaca gaagagcccc tggaaatgtg cccttgtctg acactacagc 360361 gagattaaag aagttgaata ttgcggacga atccaagaca aaaatggggc tggatagctc 360421 ccatgtgggc gttagacctt ctcctgcaac ctctcagccg acgacatcaa ctgggagtgc 360481 tgacctggac agtatactag gccatatggg gctgccgctg ggaaactctg tactagtaga 360541 ggagcagagc acgacagaat ttcactctat tctcggtaaa ctgtttgccg cacagggtat 360601 cgttcataat agaatttcag atagcagtgc tgataaaact agaaacggcg acactcatgt 360661 cattgtcttg tcattgaacc aaatgtttgc aaaggagcta cctggtatct acaagggatc 360721 acgtaaacaa atgaagaaaa acctaatctc tgaagaagaa tcaaaagtta ctgttcaaaa 360781 tttgaacgag acccagagat cgacgccttc caggtacaaa gacctgaaaa ttgcatggaa 360841 atataaactg gcagatgaaa agagattggg ttctccggat cgagatgaca tccaacaaaa 360901 ttctgagtac aaggactaca atcatcagtt tgatattaca acgcgtctga tgcccgctcc 360961 catagcatct gaactgacat ttatcgcccc aactcaacct gtctccacta ttttgagcca 361021 aatagaacag actattaaaa ggaatgacaa gaaactgata agaattgtta ttccttccct 361081 tctacatccg gcaatgtatc cgcccaaaat gtttgaatca tctgaaataa taggtttaat 361141 gcacggtgtg aggagtcttg tcaagaaata ctatgagcgg gttgtactgt ttgcttccat 361201 atccatagac attatcactc ccccattact ggtattgctg agaaacatgt tcgattctgt 361261 tatcaatcta gaacccttta accaggagat gactgagttc ttagaacgtg tttataaatc 361321 gcaaccgggg aagattcaac atgggctagt ccacatattg aaattaccag ttttcacgga 361381 ccgtggagag atgagagttt taaagtctga atgggcattt aagaatggca gaaaaaagtt 361441 tgaaatagaa caatggggca tacccgtgga tgatgctgaa ggttcagctg cctcggaaca 361501 gtcacattca cactcgcact cggatgaaat ctcacataat atacctgcaa agaagaccaa 361561 gatatcttta gactattaag aatatggttc aatttatggg aaatatacgg catgcttttt 361621 aacaagcgtg gtgaatgtat tattttttta tctgttatat cttaaatacg actattatat 361681 atatatccat cgtctttttc ctgactctaa gcggtggcag ctggaaggta gaaaaaggta 361741 tcgcctagat gtcaaaatat gaaaaagtga aatgaatatt aacaaaaaag gagcgtgagc 361801 tgcagaaaga atttgaccaa caaaagacaa ttccactcct ttggatttga aatagacaga 361861 tagaaaagga tatgaaagta ttacaattca atcaagatgc aacgtgctgt gtggtggccg 361921 cgtcatcgca tcagatttcg atttttaact gcgacccctt tggtaaatgt tttgaaattg 361981 acactaagaa ttccaagaag aagacttcaa acaataacgg ttcagcttca aactcagaat 362041 cacggaataa tgaggagagc atattaataa ctaatggctc ccgcgatcgt actgatgcag 362101 aagaagagga agataatgaa gataatgccc tcgttacagg aaatatactg aaagaagggg 362161 agtttgtcat tgaaatgttg ttttcaacta gtcttattgc tattgcagat agaggacaag 362221 gtctaaacaa aggaaaaaag ctgaagattg tcaatacaaa gagaaaatgt actatttgtg 362281 aaatagtttt cccacatgaa attgttgatg tggtcatgaa tagaaaaaga atgtgcgtac 362341 ttcttgaaag tgaccagata ttcatttatg atatatcttg tatgaaaccc ttagaaacta 362401 tcgatctttg ggaagatcat tataagaggt cccaagccaa ttcgttctca aatgcgtcaa 362461 atactggtac tttggaggga gattctgcaa atttgaacag ggtggctacc aatttactag 362521 caaatgccac tcaaaaaagt gtgaatggat ctaatcctag tgtaagaacc agaagaaact 362581 ctctaagaag taaaataagg ccaagaatgg ttttaagtaa cgatgataga agtatactgt 362641 gttttactgc gtatagctcg cccaagaaga ataagcccaa ttcagaagca ctatatgatg 362701 tagtgattta tgacacatta aatgtgacgc cagttaatta cttgaattcc gttcataagg 362761 ggaatgttgc atgtttagca gtaagtcacg atggtaaact gcttgctact gcctcagata 362821 aggggaccat aataagggtg tttcatacgg gggtagattc ggactatatg tcttcaaggt 362881 cactgtttaa agaatttaga cggggtacca gattgtgcaa tttgtatcag ctagctttcg 362941 ataagagtat gactatgatt ggatgtgtag gtgatacgga cactattcat cttttcaaac 363001 ttgatgacgc ctctaatagc ctccctggag ataattctag caatggccac tggaatgaag 363061 aggaatatat actagcatca aattcaaatc ccagtatggg aactccaaag gaaatacctc 363121 tctcgaaacc aagaattgcg aattacttct cgaaaaaaat aaaatcttca ataccaaacc 363181 agaacctgag ccgtaacttt gcttatataa cagttaatga atcgaacagg agttgcttag 363241 ggtttccaga cgaatttccc aaccaagtct atattgcctc tgatgatgga accttcagta 363301 tatatagtat tccgtcaaaa cctggtgaat gtgtgctgac taaaaataat aaatttacat 363361 aatgcatatg tgcagttttc ataatcttaa tagatattgt acgtattcac gtgtgaattg 363421 ctaaagaggg tagaaatctt caaaacaagc aatttgaaaa tatttacata ggcaatggta 363481 cattctagaa acacgaaaag ccaacaagat aactaattct caccaaaacc atctcctata 363541 ccaaggcttc atatgtgttg attcattact gccctttccc ctactagtat tgtgggtttt 363601 atcctgtaca attaactcat ttaattggtg ttccaggatt tctacctctt tctttagctg 363661 actttctctc tcctcatgct ctagtttcca ccaagagaag tgaagcagta aataaacgga 363721 agatcccatt agaatgaaca tccaaagagg cctaataaat ctttttacag ggatctcatg 363781 tcctgattct tcctcttgcg agaatttttt gagcatatct aactcctttt tgatatttaa 363841 ttttgtagta tgctcattaa tcaaatcgcg tatcagttca gtatcaacac catccaaaga 363901 atccaaatta gccaagtctt ctaggctctt gatttctttc ttcggtgacg ttgaaacagc 363961 tcttcgttgt tggttgagga ggcgcctgtg gtaataggca acggttgtta tgggaaacaa 364021 tttagttcta ctcaaagtaa tgagagcatt agagcgtctt tttaacatat tgtctattat 364081 atgctttggt tcccatttcc tttctcaaag tttacaaata taacagagtg cttagcgaat 364141 actttatttt atgagtcttg ccgttagtga ccccacccaa aataagatgc aaaccggtat 364201 acatattaga catttcccac gtatacaaat atattaagta aataagcctc gtcgtgatga 364261 acttaaatac atggtattga gagagttata aacaggtaga tagatatctt aaataaaaat 364321 aagcagataa gtaacaatgt ttaagaaaac gatggggaag cgtaaatata tgcaaaattt 364381 ccccctcagt ccttacgtat accgtatttg gcacgaagct tccacatttc cagtcttgcc 364441 tgttgctgta ggttcaggtt aggatgggac attggactac tttcactatc acttctgatt 364501 atagacccga tggacataaa tagcccaaag gtacccgctg aaccagcaat gtatttccct 364561 agtgttctaa ctacaccatc aggacctggg ccttgagttg cgatggcaaa tccaccaaat 364621 aggatgcctg tgcagacacc gacggtagta cccatcatca accccatttt gaatttgtcc 364681 caattcgaag gctgctgttg cgcataattt tgtggaagag gaggcattat atcttaatat 364741 tggacttgaa gctgttgcgc tatttgtgct atatgatctt gtgtggtgtt ctgtgcttcc 364801 ttcttatgga aaagtagtgg agtctgtttg gtaatgttgg tcttgttcgg gagttttgaa 364861 aagaaaataa aaagtggttg gctcataatg ttaagaaaga atttccagtt tccgattgaa 364921 cacagcaatc tacaggtaga cattgtgaat catgctcgaa ttacgaagtt gtagtaattt 364981 ggtcaatagt agtaggagac ttgtgcctct ggtgacttat tccggactaa gtgcaataac 365041 attgcctaaa tctcgatttt attcacagcc tagtgcttta gaagtacagg gcacatcgga 365101 ttctcgaagc gataatattt tagacgaact caaacaaagg ggtctagtgt cccaggtctc 365161 acagccagag agtttccttc ggacgaagtt gaacggtaac gataagatca aattatactg 365221 cggggtggat cccacagctc agtcacttca tttgggaaat ctagttccac taatggtttt 365281 attacacttt tacgtaaaag gtcacgacat tgtcactgtg ataggtggag ctacagggaa 365341 agttggggac ccaagtggta ggaaaacaga aagagacgtt atggagaacg atattaggca 365401 aagcaatgtg gcatccatct cgcagcaatt acaaaggttt ttcaaaaatg gcctagaata 365461 ttacagaaac cgatgtgctc tcactgaaga tgtaccttcc ggaaaatata caccaaggaa 365521 taatttcaac tggtggaaag acatcaaaat gttggatttc ttagctgatt ttggtaggca 365581 cattcgggta caatctatgt tggcgaggga ttcaatttct tcgaggcttc aaaccaaaaa 365641 tggtctggga tttaacgaat ttacttacca agttttacaa gcgtacgatt tttaccattt 365701 gtataaggaa gagaatgtga ctatacaagt aggtggtaac gaccaatggg gaaatataac 365761 agccggtatc gatctcatca ataggataca gcctataaag aataagggtt tgccatttgg 365821 tatcactgtg cccttgttga cgacggctac aggagagaaa tttgggaaaa gtgcaggcaa 365881 tgctgttttt attgacccct caatcaatac ggcgtatgat gtttaccagt tcttttataa 365941 tactttggat gctgatgtac ccaagttctt gaagatcttt acgtttttaa actcaagtga 366001 aatcaaaaaa attgtggaaa cgcatatcaa atcacccagt ctacgttatg gccaaacttt 366061 attggctaaa gaagtcacag atatgttata tggagttggc tccggatcgg attcagaagc 366121 gctttctaat attatttttg gacgttatga cggaacttta tctgctgcga agttagttga 366181 tctatgtaaa aaagccagaa ttttgcagta tgctgataga gagattgact taataaagtt 366241 aatttgtaaa ctagtaaatt gttcagtatc agaagccaga agaaaacttt cccagggaag 366301 cgtgtatctg catcattcaa aatctaaagt aaacgaaaat atttctaact tggctccttt 366361 cctgatagat gatcgagtac tgatcttgag gataggaaag cagaagtgtt ttataataga 366421 aatgcgttaa aaaaaaggga ggtatataaa gtacatgtat aaaataggca tgcgtgaggt 366481 gatattatat cattttatgc actgacttgt aaataagatt ataaacgatt attcatcttt 366541 actacttgcg aacatttcac tgtcacacca ggctatgagg gcccacagcc agagagtcgc 366601 agggcatagc agtaatacac accagtagtg caggaaagag tcattgttgc gtaaccagta 366661 aaatgtagca agactaatta ggagtaccga gtaagtaaac cctaaaacca aaaagccttg 366721 gtcacgtggt ctcatgcgct tataaattct caatcatgta attgaaacag tcctgttgcc 366781 tagtttcaac tgttctatgc ttcttgatgt tttcgaaact ttgcgtagtg taatcttcct 366841 tgtattgtag cgaagaaaaa aggatgcgtt gggaacagat atagaagacg taaaacaacc 366901 tgaagaaggt aacaggtgga gtagcaatgg gagaggtata cgaaaaaaat aacatagatt 366961 ttgattcaat agccaaaatg ttgttaatta agtataagga tttcatactg tctaaattca 367021 agaaagctgc acctgtagag aatataaggt ttcagaattt agtccataca aatcaattcg 367081 cacaaggagt cctaggtcag agtcaacatc tctgtacagt ctatgacaat ccttcatggc 367141 attctatagt cctggagaca ttggatctgg atctaatata taaaaatgtt gataaggaat 367201 ttgccaaaga tgggcatgca gagggggaaa atatatacac ggattatcta gtaaaggagc 367261 tgcttcgcta cttcaaacaa gattttttca aatggtgcaa taaaccagat tgtaatcatt 367321 gtggccagaa cacttcagaa aatatgacac ctctgggcag tcaagggccc aatggagagg 367381 aatctaaatt caattgcgga actgttgaga tctataaatg caaccgatgc ggaaatatca 367441 ctagatttcc tcgttataac gatccaatta agttgctgga aactagaaag ggaagatgcg 367501 gtgaatggtg caatttattt actttgattt tgaagtcgtt tgggttagat gttcgctacg 367561 tctggaatag agaagatcat gtttggtgtg aatatttttc aaattttttg aataggtggg 367621 ttcatgtcga ctcctgtgag caatcattcg accaaccata tatctattca attaactgga 367681 acaagaaaat gagttactgt attgcgttcg gtaaagatgg cgttgttgac gttagtaaac 367741 gctatatcct ccaaaacgag ctgcccagag atcaaatcaa ggaagaagat ttaaaattcc 367801 tttgtcaatt tataacgaag aggttgaggt attcgttaaa tgatgacgag atataccaac 367861 ttgcatgtcg cgatgagcag gaacagatag agctgattag aggaaagaca caagaaacga 367921 aatccgaaag cgtcagtgcc gcttcgaaat catctaatcg tggtagagaa agtggatcgg 367981 cggattggaa agcacagcgt ggggaggatg gtaaatagag aaataaaaga acagattatt 368041 atgtgtaagg aattttatct aagaacatat ttataaaact aactcatcaa agctgcccaa 368101 gaactcggca gcttgctttg ttaaccagga attactttca ttgtcgagat aagccaaatg 368161 tccacccaag tcagtctcgc ataacaacac acaaggattt tctctagctt gtttgtacgg 368221 aattacgttt tcacctgtaa ctggatcatc cgttgcgttg attattaaag ttgggatttt 368281 gatattaggc aatctattta tcgaactggc ctttctataa tatgttaacc cgtccggcag 368341 gcccatcgat ggggcagtga aaagattatc gaattctaat atgtctgtaa atttttcagc 368401 cttttccaaa ttttctctgg tatacgtata aaagactggt ttctcaactg tcggtttgtg 368461 cgaaacctca aaattctctg gtacctgcaa ctcattcata ttaaccttga cagtccttgt 368521 tagaaattgt gttaaagttc tagaaaaaat atggttggac caccaatcat gagccaactt 368581 gtcccaagtg tgtacgaaat cccatgggtt tgagagagcg actgcagcat ttaatggaca 368641 gttatctcct tcttcaccta agtagttcgt tagcatggct gctccaaatg atgttccgac 368701 tgcatatatt tttctttgcg gaaatagagc tttttggtgg ttcaaaaatt ctctcacatc 368761 acctgtgtgt aatgcggtaa agattctacg ggtggtgact ttagatcttg agcaacctct 368821 agcattaagg actaccactt ggaatttacc gtcaccgact tttgatagat cttcagataa 368881 tgccctgatg agaggctcat ggcttccccc tgcaagacca tgaagtacta ccactaaagg 368941 gtaagaataa cccttagaat gacatttttc aagttcctca gaggatagat atctagttct 369001 cgggtgaaga cgaggccaac cctttggatg ggtggccttt tcatcgttcg aaaattgttt 369061 ctcgttaaaa ctagcctttt cagcatttaa tgaatatgtt tgctcccatt caggcataac 369121 ccaatctgca gtgcagaccc ctccatcaga aaattttata atctctcttc cataaaatac 369181 ctgaaatttt ttggaaaaat caccggctga caaataaagg gtctgtaagt aacctgtgaa 369241 aagcaagctg tttaacctaa aatttgcacc atctttgagt gtaggcacgt gtttggttac 369301 gaattcatga agaggaattt ggcgcttaga atctctgaaa gccaaagact tggttccttt 369361 ctctcccagt acatgtttga cggtgccgtt atagccccaa tggctaggag tgacagttgg 369421 atagtaaccc gagcgaaaca ttaaaatgac aaatatgaaa atacttgata tcttgatctt 369481 tttgctaatc ttcaaaaata ccgaaaacta agtaggcaac cagatgcaga acccttctta 369541 tataatcgat tcctgtaagc aagtgtcagc aaatagcttc tatatagaga cctttcggtg 369601 aaagtatatt aaagccggcc ggaaattgag taataataac cgctaattat gcggtgtgtg 369661 gattcagatt tttgccagga gcgataacct tcaaatctaa aactactcac tataagcgat 369721 gaagcaacca gatggtagcg ctttggtgcc ggttctcttg aaggtttgta catgtgcgag 369781 ttcatgaggt tacaatatag aaggtttata cagtagagct atacaggata atggaagttc 369841 agttttgttc ggctttttca ttgatggctt tcttcttatt gctttctctc ttggcttgtt 369901 tcttcttcat tcttttcagt ttctttttgt aactataagt atccttctca ccaaaaccgt 369961 aaagtggctt aaaactctct agtacaccgc aatcttcgaa caggttggga aagatccaga 370021 acccaccaac atctttgtag acaattaatg acaaaacata taatatcaat ctcaggatag 370081 cgacagcaaa gaagcctgct aagatgccga aggcacccag agacacataa taggagccgc 370141 gtctcatgga gcgcggccac aatgggtagc atacgagcgc caatatgatg gacacgacac 370201 caatgacgat caagtaatcc atgtaggttc tagggttata gttccaaaca aagtattcat 370261 cggcttccaa ttgtgcttta ttcgaaacaa tcaagtgcgg aaagtccttg cttggcttca 370321 atccatgctc tttgcattct tgactatgca attttttcac tgggatcacc atttgtgcct 370381 ttataagttg aataaagatt tcacgtgact taagctggtc ttcgatcttg ttagaaggta 370441 tagttggata tatctctggc tgtcttgcag atttgttggc atactcctca gaatgcagtg 370501 ccctaacaaa tctcttgtaa cggaagaagt ctgtctgctt ggcctggaat aaaccctgcc 370561 tttgcttcaa ctccttatgg ttgcgtaaaa gagtagcaat ggctgtagca gatccgccat 370621 tgacactagc acctgcattg ctacctggac ctacggctga catgttctcc tgtgtttgct 370681 cggctaccat actgcattca actgcaatta taaaagccca ctcttctccc tcttgatttg 370741 tatgccagta ttgggaaaac gacacgtcta ttccgtcgca cacgatcttc actttctttt 370801 tttttttcaa ctgaacgaaa agttttttcc gcagctcatc gcaaagaaaa attttcacct 370861 atgtactacc tcatctaata caatataaag aatacacttc agatttagga gttgcagcgt 370921 ttataaaaaa gtaagtgtac cctccaaaag caaacacatc tccctcctat accgaagatg 370981 caactttcat ggaaggatat ccctactgtc gctccagcaa atgatttgct ggatattgtc 371041 ttgaacagaa cccagagaaa gacaccaact gtgatcagac ctggtttcaa gattacaaga 371101 atcagagcgt tctatatgcg taaagttaaa tacacaggtg aaggtttcgt ggaaaaattt 371161 gaggacattt taaagggttt tcctaacatc aatgacgtgc atcctttcca tagagatttg 371221 atggacaccc tatacgaaaa gaatcattac aagatatctt tggcagctat atctcgtgcg 371281 aagtcccttg tggaacaagt cgccagagat tatgtcagat tgctaaaatt cggtcaatct 371341 ttatttcaat gtaaacaatt gaaaagggcc gctttaggta gaatggcaac tatagtcaag 371401 aaattgaggg acccattggc ctatttggaa caagtcagac agcacattgg tagattacca 371461 tcgatcgacc caaataccag aaccttgctg atctgtggtt atccaaatgt cggtaagtcc 371521 tcgtttttga gatgcattac caaatcagac gtcgatgttc aaccatatgc tttcacaacc 371581 aagagtttat acgttggtca ttttgactac aaatacttga gatttcaagc tattgacacc 371641 cctggtatcc tagatagacc cactgaagaa atgaacaaca ttgaaatgca atcgatttat 371701 gccattgccc atttacgttc ttgtgttttg tacttcatgg atctttccga acaatgtggt 371761 ttcaccatcg aagctcaagt taaactattc cactccatca agcctctatt cgccaacaag 371821 tctgtcatgg ttgttatcaa caaaaccgac attatcagac cggaggattt agacgaagag 371881 cgtgcacaat tactggaatc tgttaaggag gttccaggtg ttgaaatcat gacttcttca 371941 tgccaactgg aagaaaacgt tatggaagtt agaaacaaag catgtgaaaa actattggct 372001 tctagaattg agaataagtt gaaatctcag tctagaatca acaatgttct gaacaagatt 372061 catgttgctc aacctcaagc aagagatgat gtcaagagaa caccatttat cccagaatct 372121 gtcaagaatt tgaagaaata cgaccctgaa gatccaaaca ggagaaagtt ggccagagac 372181 atcgaagctg aaaatggtgg tgctggtgtc ttcaatgtta acttgaagga caagtaccta 372241 ttagaagatg atgagtggaa gaatgacatc atgccagaaa tcttggatgg taagaatgtt 372301 tatgatttct tggaccctga aatcgctgct aaactgcagg ctcttgaaga agaagaagaa 372361 aaattggaga acgaagggtt ctacaattct gacgatgagg aagaaatcta cgacggtttc 372421 gaagcatccg aagtagatga tatcaaggag aaagctgcat ggattagaaa tagacaaaag 372481 acgatgattg ctgaagcaag aaataggaag tccttgaaga acaaagctat catgccacgt 372541 tctaaactaa ctaagtcctt tggtaaaatg gaagaacaca tgtccacttt gggccatgac 372601 atgtcagcct tacaagataa acagaaccgt gctgctcgta agaaccgtta tgttgaaaga 372661 ggttctgatg ttgtttttgg cgaccaagat gctttgacag cttccactga aaacggtgtc 372721 aagttgagac aaaccgatag actgttggat ggtgttgctg atggctccat gagatccaag 372781 gccgacagga tggccaagat ggaaagaaga gaaagaaata gacatgccaa gcaaggtgaa 372841 tctgatagac acaatgctgt ttccttatca aagcatttat tcagtggtaa gcgtggtgtc 372901 ggtaagacag atttccgttg atttctctac ttcttattct ttcttttgca tgtactttaa 372961 aaaaaatatg aatataaaat gtggatgtac gtacacgaca ttctaatctt tttgggctgg 373021 taggattacc atttacattt gattatctct ctcactatta gtggtttctt tttctttctt 373081 tctcactttt tctgtatctt ttttttaaaa aaattttatt taatctgtat aataataata 373141 aaccgattta aattatccaa caagccgacc cctccatgtt ctactatttt tttgtatgtc 373201 actggatgta tacaaataat taagcatgtg gaaaaagaag gggtgggata gcgtcaagat 373261 gacacttcta cttttttgtg acacatcatc atgcaaccta tcgagtctcc cacgaggttg 373321 acaaataaga aattgttatc gtttttgcag tgtatcgtat aaggcaacaa tagcgatgtc 373381 tcccatcaat tgactgataa attcctgcaa actatcattt tttttttttc atccttgtgc 373441 cgcgtctgta gccgaaaatc tgagagtgca tgaatcttaa aaaacagaag actcatcgcc 373501 gtctttggca cattggggtt gtctttgact tcttttgctt atttttgctc actttgctta 373561 ttttacctat ttaactagag gttctaaaag aatagccaac cagcgtgtag ttcttatttc 373621 taatccttgt cttgttaagt tgaaacttgt gatattggct gaacaaattc tccgcattta 373681 gacaacacac aaattacagc tttcccctag taacgattgt tgattgagct cagacaatac 373741 gcgcaattta aaaacgtttt atagtgtaag agaagacaag tacaagaaaa aaatggttgc 373801 caattgggta cttgctctta cgaggcagtt tgaccccttc atgtttatga tggtcatggg 373861 tgtcggcatt tcatcgaata ttctatatag cttcccatat cctgcaaggt ggctaagaat 373921 atgctcctac atcatgtttg ctatcgcttg ccttattttc attgctgtgc aggcactaca 373981 aatattacat ttgattgtct atattaagga gaaaagcttc agagaatatt ttaatgactt 374041 tttcagaaat atgaagcaca atttattttg gggtacttat cccatggggt tagttacaat 374101 tataaatttc ttaggagcac tctcgaaagc gaacacgacg aagagcccca ctaatgccag 374161 aaatttgatg atatttgttt acgtcttgtg gtggtatgat ctcgcagtct gtctagtaat 374221 agcgtggggt atctcgtttc tcatctggca tgactattac cctttggaag ggattgggaa 374281 ttatccttca tataatatca aaatggcatc cgaaaacatg aaaagtgtat tgctactgga 374341 tatcattccg ctggttgtcg tcgcttcaag ttgtggaaca ttcacaatgt cagaaatatt 374401 cttccatgcg tttaatagaa acattcaact gataacgttg gtcatatgtg ccttaacgtg 374461 gctgcatgcc attatcttcg tcttcatact gattgcgata tacttctgga gtctttatat 374521 taataagata ccaccaatga cacaggtttt caccttattc ctgcttttgg gcccgatggg 374581 ccaaggaagt tttggagtct tattgcttac agataatata aaaaaatatg cgggcaaata 374641 ttacccaaca gataacatta caagagaaca agagatattg actattgcag ttccatggtg 374701 tttcaaaatt ctaggcatgg tttctgctat ggcattgctc gctatgggct attttttcac 374761 cgtgatttct gtcgtttcaa tcctgtcgta ctacaataaa aaagagattg aaaacgagac 374821 aggaaaagtg aagagagttt ataccttcca caaaggtttt tgggggatga ctttcccgat 374881 gggtactatg tctttaggaa acgaagagtt atatgtgcag tataaccagt acgttccctt 374941 atatgcattt agagtcctag gaaccatata cggcggtgtt tgcgtttgtt ggtcaattct 375001 atgcctttta tgcacattgc atgagtattc taaaaagatg ctgcatgctg cccgtaaatc 375061 ttcattattt tcagagtcag gtacggaaaa gacgacagtt tctccgtata acagcattga 375121 aagcgtggaa gaatcaaact cggctctaga ttttacgcgt ttagcataaa attgttggtt 375181 ttatacgtac ataattggca agcatttcat gtaggagtct caatagatag tttaattcat 375241 ttgcacggcg ctttgctgct tttgcttctt cacgttggtt ttcactatgc ctgatatttt 375301 ttgacgtcac ttagtaagca cgacccttgt caatttttcg aggatttcgg agctttccat 375361 ttggaatcta ctattaaaat cagtctaaaa aagtataaga aacacttctg gtttttctca 375421 tgcgcttctc actctcagta tattttgctg ctttccttca tatgtatata tatctattta 375481 catattagtt tacagaactt tatgctttct gcaaccaaac aaacatttag aagtctacag 375541 ataagaacta tgtccacgaa caccaagcat tacgattacc tcgtcatcgg gggtggctca 375601 gggggtgttg cttccgcaag aagagctgca tcttatggtg cgaagacatt actagttgaa 375661 gctaaggctc ttggtggtac ctgtgttaac gtgggttgtg ttccgaagaa agtcatgtgg 375721 tatgcttctg acctcgctac tagagtatcc catgcaaatg aatatggatt atatcagaat 375781 cttccattag ataaagagca tttgactttt aattggccag aatttaagca gaaaagggat 375841 gcttatgtcc ataggttgaa cggtatatac cagaagaatt tagaaaaaga aaaagtggat 375901 gttgtatttg gatgggctag attcaataag gacggtaatg ttgaagttca gaaaagggat 375961 aatactactg aagtttactc cgctaaccat attttagttg cgaccggtgg aaaggctatt 376021 ttccccgaaa acattccagg tttcgaatta ggtactgatt ctgatgggtt ctttagattg 376081 gaagaacaac ctaagaaagt tgttgttgtt ggcgctggtt atattggtat tgagctagca 376141 ggtgtgttcc atgggctggg atccgaaacg cacttggtaa ttagaggtga aactgtcttg 376201 agaaaatttg atgaatgcat ccagaacact attactgacc attacgtaaa ggaaggcatc 376261 aacgttcata aactatccaa aattgttaag gtggagaaaa atgtagaaac tgacaaactg 376321 aaaatacata tgaatgactc aaagtccatc gatgacgttg acgaattaat ttggacaatt 376381 ggacgtaaat cccatctagg tatgggttca gaaaatgtag gtataaagct gaactctcat 376441 gaccaaataa ttgctgatga atatcagaac accaatgttc caaacattta ttctctaggt 376501 gacgttgttg gaaaagttga attgacacct gtcgctattg cagcgggcag aaagctgtct 376561 aatagactgt ttggtccaga gaaattccgt aatgacaaac tagattacga gaacgtcccc 376621 agcgtaattt tctcacatcc tgaagccggt tccattggta tttctgagaa ggaagccatt 376681 gaaaagtacg gtaaggagaa tataaaggtc tacaattcca aatttaccgc catgtactat 376741 gctatgttga gtgagaaatc acccacaaga tataaaattg tttgtgcggg accaaatgaa 376801 aaggttgtcg gtctgcacat tgttggtgat tcctctgcag aaatcttgca agggttcggt 376861 gttgctataa agatgggtgc cactaaggct gatttcgata attgtgttgc tattcatccg 376921 actagcgcag aagaattggt tactatgaga tgaagcaacg aaactagacg tccaatctgc 376981 tgttgctata ctggactttt gtactcttgt aaacaatctt atatagcatc ctgaaatacg 377041 tagtaatttt gtcatttctg ttcaaggaca agggttcctt tttttttcag actattagct 377101 actgtggact cgcttggata ttcagttgag gatacattcc gactctcgtt tacaatacat 377161 atgattattt ttctttttgt taattatata aaaaataaag ttatttgatt ttaagcttaa 377221 aaatacacaa aatacagaat aagaaaggag tttttgaaca aaagaattta tcttttactg 377281 ctttctaact ttaagccttc aaagaagaag ctcttctctt tctgatttca gccttctcag 377341 cctttctttc agacaatctc ttagccaaca attgagcgta ttcggcagca gcttctcttt 377401 gagcttgagc gtttctgacc ttcaaagctc tttggtgtct ctttctttgc aatctttgag 377461 gagtaaccaa tctttggatc tttggagcct tggtgtaagt cttttcaccc ttggtgactt 377521 ctcttctgat gacgaaatca cgaacgtcat cttccttgga caaaccgaag aactttctga 377581 tgttgttagc tctctttgga cccaatctct ttggaacagt agtgtcagtt agaccttcca 377641 attcttgctc acccttcttg acaatgacca aagccaagac agccaaatct ggaccaacaa 377701 tggcacctct gacggacttt ctctttcttt caccatcacg tcttggtctg taacaagaaa 377761 cgttcttggt caacaacaac ttgattctag ttggcaacaa aacaccttgc ttcattggga 377821 aaccttgttt gtcgttacca ccagagatct tgaagacgta acccttgaat tcgtcaccaa 377881 cggcttcacc atcgacttct tgaccgattc tcttgtcgaa gaaaacacga atacggtgtt 377941 catcatcaat ttcgaaggtc ttttgagacc cgttaactgg gtaagaaatg ttcaactatt 378001 ttaaattttc aacaggttat taagaaaatt tgttagtata ctattgcaaa attaatgttt 378061 gaatagggtg aagtttatta ctctagagaa attattaagt ggaagatgaa aaagcttgtc 378121 ttttattgac tatactccaa gtatatgaac tgcttcaatt tcacggtttg tagtaacagt 378181 atatgtaaac ccgctctgtt tgtttaaaaa taacgccaca aacgcatcaa ttagtatatg 378241 gtagtcttcc tgcttctttc cataaaaaat ttctaaaatc tttacgacgt ctggttctgt 378301 ttagttcttt ctcactttca aactttcatg ccatttttcc acatataaag ttctctgttg 378361 cccctcaata atagtatcat aaatcatacc ttcatgatgt atagtctgtc ttcactcttt 378421 tgtcacttct cttaagcaaa tataaaaatt caatgacgaa taagcattaa ccactttatc 378481 cttggtaaca ctgtatatga aatttcaaag aaactgcagc atcatgatgt tcctagacgt 378541 cggtactgga attcccaccc agtagactta cctaggtagc ggcattcctc caacgcttac 378601 caggagagat aactttcccg ctagaatcga tagaggagcg tggaattacg ccaatcttcc 378661 aagtgggaac gggcagagtg tccagtggct tcctgcctac agaatgcacg gccccagtgg 378721 gattggtgca atcgcgcacg ttccaacttt ccgatgctcc ggcgcgtcga tgacaatttt 378781 acacatgaaa aacgaactat gtaaaaatag ttgaaatgta tgggttcaat gagaactcga 378841 atgtacggat gttttctctg aatgaacctc ttgtcttctt ccggcttctg cttacatcaa 378901 actccaggcc aggcggcaat tcattttagt tgctaatgca caaaagagta cttaaatact 378961 atcattattc agaaaatgca attgagtttt tcgtttttct tccttgtttg ggttattcac 379021 tacgtaaata tgtgcattta caataatata aatataaatt ttttaaatga aaagaagttt 379081 cttatgcttg gaatattcat actggtcaaa ttttttggtt tatattttgc ttgaattttt 379141 ttctcctgaa atatcagtcg aaaaattaaa gaatttagtg cctagtggtg tttgagcagt 379201 atttatgtat ggagtcagcc cggtatttcc attatatgcg gtggcagcag catcatatgt 379261 acttgagttg gactgattgt tcgagtcacc atcggtagta tgttctgaaa tagcagctcc 379321 atttacgggt gcatcttcat tattactata gtaactgtta ttgctattgt tactgttatt 379381 gtcgttgccg ttgttgctgt tgttgttgct gctgttgttg ttgttattgt tgttgttgtt 379441 gttagtgttg ttagtgctgc tgatattgct ggagttgccg ttgtttacgg ccgtctgtac 379501 gggagggaaa gtaccaggat tgtttgtgtt tcccggcttg gcactgttgg gtcccattga 379561 ccagtctgga aacatcgata tagaagaaac atttggagaa ttactcatca aatcatgtac 379621 gaacttcgat ggcagtgaac cagttggagg gccattgctg gtttcagggc cggaaaaagt 379681 tgaagggggg cgtccggtta atgttgtagt taatggtact gtttggctct gttttttgaa 379741 agacatttgt tggtattgct gggtttgtct ttgagctaaa aaagatgtat tttgttggaa 379801 aggtccgcca ggaatattcg atggttgcaa gggagtggca atgtatggct gtgttgcaga 379861 aaaaagaggt gaagacccac ttccgaaagg ataagggtga ttgttattgt tactgccatt 379921 accattgtta gaaccgttag gcgcatttgc atttggcaat tttattacca ttctgccatt 379981 attacctttt tggagagtta aggggcctga ggcagatgcg gatagtggag aaattttgct 380041 agacctactt gttttgtttt ctttcattat ctgcgaagag cccatactat tgccgttggc 380101 cgatgtggag gaggcagagg agggttcact tggaatagcg gaattactgc tgaaattgtt 380161 gttcggaatt ctcacacgaa gtaccggtct ggcggacaat ttccttcttg ctttgacagt 380221 ctgctgaata gagtcttcca aagaattaga tggtgactga gtgtagttgc tgttgtcatt 380281 attattgctg ccactattgt taattttgtg ctcctgttta ggggtccttg aggatgcatt 380341 tgtaaatggc ttactgaact tgttcggtga aatggaaatg ggtggaggac gaccattaaa 380401 ggaagagttt tgaaagcttg gtaattttgg aaaatccatc gtggaaggag aagatgaact 380461 ggatgaaggc tggttaagat tgtacatgct actatggtat ggtctcgata tattttgctg 380521 ctgttgctgt tgcggagttc tacttatttg caaaggatcc ggtttcaatc ttttcaaatg 380581 ttgtaaaggc ggcagcgcgt tctcaggatg acgtttattt tgctcactac catccatctt 380641 tgaaatgagt gcggtcgggg ataacaactt catgtgtgca ctcggtatat ttttatcaga 380701 ggctttttta ttcgaatgca tatttgaatt cctctcaaaa ttgccatgat catcgtcgtc 380761 ctcatcattg ttctcatcat catcattttc tgactggttc attcctttaa catttgattt 380821 cgaaggctta tttgacatag acgacctgag taggtcttga tttatgttaa cggatgcact 380881 tttgtgaaag tctccataat cggaaggatc tttcacttcg tgaagcaagt ttttgtcatt 380941 ttggtagtga tagattaaat cattcgtatc cacagaggaa aactcataga acgtgttatt 381001 ggaccccagt ataatgacgg ctatgtctac ttgacaaaga acggatagtt catgggcctt 381061 cttaaaaagg ccagctttac gttttataaa cgtgacagcc ctatttctgt catcagaaat 381121 tctctggatt tcaatcttcc gtctacccat gttgtatcta tagtatagtt ttgcgacact 381181 ttaatattta agtttttttc acgcttcagc ctgtttgctc cgggggatat taacctcaca 381241 acgtgataga aaccttgaaa aaaaaaaaga ataattctgc ttgccagctt tcaattactt 381301 taacgagtca aaagttgagt tggctatcag gagtaggcag ttctaattga atcagtcgtt 381361 gaacacttta gaacaggctc gcttctttct tacgtttctt tttgtctgtc ctttaattat 381421 tattgttcag aggaagatcg agctgtttct attattagct ttcatctctt ccgttttatt 381481 tttatcagaa atctgaagta aatttttttc tttctttctg cggcttggca ttcatcaccc 381541 ggtgatgctg cgccgttaag agagcccaat aatgataaga cgatttctgc atttaatata 381601 cgactgagac agacttcgtc accgtggaag tattttttgc gaacgtggaa gtatttcacc 381661 cacgtatggc aggcaagaac gcattttcaa taacgttatt tccacggaaa aatgtgatta 381721 gtgtagtagg ttaggaacgg gagataactc ggccgcttgg tttgaatttg tttcccttcg 381781 attttgtttt cattgcttga gtaaaagaag ctaagctaac atctgcctta ttcttctcag 381841 ccttttcgta tatatatata tatatatata tatattagga cccagagaac aaggtatcat 381901 atattaattg tcttgccaac tatgtaattt ggctgttacg gaagacccac atcaggcggc 381961 agaaatggtt ttagttaagc aggtaagact cggtaactca ggtcttaaga tatcaccgat 382021 agtgatagga tgtatgtcat acgggtccaa gaaatgggcg gactgggtca tagaggacaa 382081 gacccaaatt ttcaagatta tgaagcattg ttacgataaa ggtcttcgta cttttgacac 382141 agcagatttt tattctaatg gtttgagtga aagaataatt aaggagtttc tggagtacta 382201 cagtataaag agagaaacgg tggtgattat gaccaaaatt tacttcccag ttgatgaaac 382261 gcttgatttg catcataact tcactttaaa tgaatttgaa gaattggact tgtccaacca 382321 gcggggttta tccagaaagc atataattgc tggtgtcgag aactctgtga aaagactggg 382381 cacatatata gaccttttac aaattcacag attagatcat gaaacgccaa tgaaagagat 382441 catgaaggca ttgaatgatg ttgttgaagc gggccacgtt agatacattg gggcttcgag 382501 tatgttggca actgaatttg cagaactgca gttcacagcc gataaatatg gctggtttca 382561 gttcatttct tcgcagtctt actacaattt gctctatcgt gaagatgaac gcgaattgat 382621 tccttttgcc aaaagacaca atattggttt acttccatgg tctcctaacg cacgaggcat 382681 gttgactcgt cctctgaacc aaagcacgga caggattaag agtgatccaa ctttcaagtc 382741 gttacatttg gataatctcg aagaagaaca aaaggaaatt ataaatcgtg tggaaaaggt 382801 gtcgaaggac aaaaaagtct cgatggctat gctctccatt gcatgggttt tgcataaagg 382861 atgtcaccct attgtgggat tgaacactac agcaagagta gacgaagcga ttgccgcact 382921 acaagtaact ctaacagaag aagagataaa gtacctcgag gagccctaca aaccccagag 382981 gcaaagatgt taagttagat tttcatgggc ccactgatat atagaaggct aaataacgag 383041 aatcatatat actgtaacat gacacctgct gatttttact gatcgtagcc attcggctca 383101 tattacttca tgtccctttt ttaaatccct cgttcccgga gagtggcata gcatgtccga 383161 tagcgtacgc caacctacag aatcagggga tcagatttcc tgaaagcaac ttatccatca 383221 gtttcttttt ataatgccat aatgacaggt gtgcctttct tattttactt cgcttgcttt 383281 ctttctattg catgcttcaa tctttgaata tttgctaata gtgaaaaaaa aaaaggaaat 383341 aactatctgg tttatctgca ttgttcttcg tttttcaatt caagaattta agcaaaagga 383401 tatatcatag aacctagtga atttttaaga aagtaagata aagaaaaaaa tcaaatgctg 383461 ttcagctggc cttatccaga agccccgatt gaaggttatt ggggcaagcc aacttctctg 383521 attgattggt gcgaggagaa ttatgtcgta tccccctata ttgcagaatg gtcaaatact 383581 attaccaata gtatattctt aatgaccgcc ttctattcta catatagcgc ttggcgtaat 383641 aagttagaaa caaggtatat attgatagga atggggttct cgctggttgg tattggttcg 383701 tggttatttc atatgacttt acagtatcgt tatcaattgc tagacgaact accaatgctg 383761 tatgcgacca tcatcccatc gtggagtatt tttgcagaaa ctcaagaaat cttgattaag 383821 gatgagaaga aaaggaagga aagctcattt agaatccaaa tggtcatttc ttttatcatg 383881 tgtggtatag tcaccatttt aacctggatt tacgttgtcg tccaaaagcc agcaattttc 383941 caagtccttt atggtatatt gacgcttcta gttgtggttc tttctggctg gctgacctac 384001 tatcacgttc atgattcatt tgcaaagaaa aatcttttta ttactatggt tatgggcatg 384061 attccttttg tcattgggtt catttgctgg caactagata ttcacctgtg ttctttttgg 384121 atctatatcc ggagaacata tttggccctg ccattaggtg ttctattgga actgcatgct 384181 tggtggcatc ttttgaccgg tactggtgtc tatatcttcg tcgtgtattt gcaatatttg 384241 agaatattaa cccatggaaa tccaaatgac ttcttattta tatggaggtg gggatttttc 384301 cctgagctgg taagaaaggg cttaccgatt ggtacttctt attcactgga gtatctgggg 384361 ccaattgtaa atacacaggt agatgatgaa acaaaaaaga ataactaagg agtgattttg 384421 tgccatccat ttgaatcttc aaaatatatg tacgtatatg ttatgtatgt atataaattg 384481 ttgtacgtgc aattgaccga acgtgtatat ttgtatatag atatgtgaca aactaaagag 384541 cttacacttc gttccttccc ttctgttcac ctttttttat tatgcctgac tattctaaaa 384601 tttatgttta tgtggcgtaa aatatctttc ttctgaaaac acatgcagca gttactccca 384661 tcataaaagg aattaataaa tgaatagtat aaacaattat ttacttaaat atatttaaat 384721 ttctgcttgg aaaaccggcc atgtcggcgg cacataaaag ttctatttac ctttaaattc 384781 ttttcgacat gtatggaccg tctagttcat atcctagttt accatagtaa tttcttacac 384841 caacaccaga aataacagaa attttctctg aaccatgctc ttccttggcg attctttccg 384901 cttcttccat caatagagta ccaaaccctt gatgctggaa tttacgagga tctcttgaat 384961 gaagtggaac cacagaacca taaacatgca attctctaac aatagaagtc ctctgggagg 385021 tgaattcttt tctatatgta tatttctttg aagcctttct caatctcagc aaaccaatca 385081 gtatatcttt ctttggatct tcatatgata aaaaggtttc ccaaccacca tttgcatagt 385141 aatcccttct gataagctcg acctgatctg gttgaacttt atgatgcact tcttggatac 385201 ccacttccct agtacgaaca tccctacaag ttgtacccaa gtccttcatt ctagctaatg 385261 ccaattctct caagttacca ttgtcaacac ctgaggtaac caagggcatt ggaatgtctc 385321 tttggacacg gtagattctt gtccatgggg gcactagggc caagattcta gcaactaagt 385381 ccactaaggc gttggcacta taagacttat acctgcccgt tttccaaagt tcgtataaac 385441 ctgtacccct aatgactaaa gttggataga ttttcaaccc atcagtccta aaatcaggat 385501 tttcaaaata ctctttgaac tgttcaatat ctctttccat cccaacattt ggtaaatctg 385561 gcatcatgtg agaaacaacc ttataaccag catctttaga cacagcaaaa gtttcacaaa 385621 cagacctaac ggtgtgtcct ctattagtat cacgagcaac gtcttcgtac aaggactgaa 385681 caccaatttc taatctggta cagccatatt ttaacatatc gtccaaatgt gtttgcgtac 385741 aataatcagg cctagtttcg attgttatac caacacactt cgttaaactt tgttgcgaat 385801 aaagaatagc ttcatcaata tcattaccat tgaacccaga aagtgcatta tgcaatttca 385861 caataaaatc ttcacgatat tcttttggta atgacataaa tgtaccaccc atcagaacat 385921 attcgacttt atcgatggag tgacctaact gtttcaattg ttccacccta ccacgtgctt 385981 gttcataagg gtcataacga gctctgatgg cacgcattga agttggttca tagcctgtgt 386041 aagattgtgt agaatactca aaatctgaat ctggaccacc tggacaataa acacaaatat 386101 tacctgtata tgcaatgtga ggacaacgat gtggtttaca cataacggct accactgcaa 386161 tacccgatgc tgttcttact ggcttagcct tcaatttggg taataaatat tttttgtatt 386221 ggtctggaat agaattaatg atatcggtta accttggttg ttgctttagt ttatatttct 386281 ttgaatattt agtaatcaaa ccattcagat taatttctct tgttgttccc gaggttaaag 386341 aatctgttaa ctctaatgtg atatcagcac aacattgtat aaacctttcc ttttcaggtg 386401 ctagcttttt tttgttagtt tttgggcctt ttccatgacg agccatcttt gtcagggtgt 386461 tcttcgattt tccttaggtg cttttaggac ttgtttattt caaaactttg cactggataa 386521 tttgagatga gctaactaaa tttcaaaatt ttttgaccat tttttttttt tcatgaggaa 386581 gagccagtga cagtaaataa taaaaggtga aatgattaaa caatgaaagc ggcagaaaaa 386641 taaaatcaaa cagtggcagt attgactttt gaaaatcaga agttcatcct aagttaagac 386701 tttcttcttt taagtgcttt ctccttctct cactgtctta tcgctgtata tctcattgtt 386761 gaataatata acacaacgtt ataagtgatc atcactttct gatccataat ttcaaacctc 386821 aagcgaccgt acatgtggca ttttccacta taaacttacg agcaagagaa agatatacgg 386881 aaaaggttaa ttggcaggtt acacaagatt ttggtcattg aatatttgca gccctcctgc 386941 ttgagaaact ggacaacaac tgttatcaat attccctttt caaaatagtg gtatttaact 387001 ggccataacc aaggaaaccg ttgtacctat tattttgtat agtcttcatt taataacgtg 387061 ttaagaatga cacctgaagc caagaaaagg aaaaaccaaa agaagaagtt gaagcaaaag 387121 caaaaaaaag ctgctgagaa agctgctagc cacagtgaag aaccacttga attaccagaa 387181 agtacgatta acagcagctt caacgacgac tcggtgaacc gtacagaatc tgacatagct 387241 tcaaaatctg atgttcctcc ggtctcatca tctaccaata tctctccggc taatgaaaca 387301 caactagaaa tacctgatac tcaagaattg catcataaac tgctcaacga ctctgatcaa 387361 catgatatta ccgcggactc aaatgatttg ccagacaact caatcgttga acatgactct 387421 gttattaccc aaacaaaacc agccatgtct caagaatacg aagagactgc cgctcactta 387481 tcttcgagaa atccatcgct cgatgtagtc gcgggagaac ttcacaataa taatgaacat 387541 acccagaaaa ttgccgtatc cgctgtggaa gaggattctt tcaatgaaga agagggtgaa 387601 aatcacgaca gcataataat ttcatcatta aacgatgcta ccccttctca atataatcat 387661 tttctcccat ccgatggcaa tcttctttct ccagaattat cttctggtga tacgccaact 387721 cacaatgttc ctctaggcac aaaagacaat gaaataaatg acgatgagta ttgtaatgat 387781 aaggaaatta gtttgaacgc aaataatgtg cttcctgatg aactttcaaa ggaagaagat 387841 gaaagattaa aactagaaac gcatgtatca accgaagaaa agaaacagga tatcgctgat 387901 caggaaactg cagaaaactt atttacgtct agtacagaac catctgagaa taaaataaga 387961 aattctggtg atgatacctc catgttgttt caagatgacg aaagtgatca gaaggttcca 388021 tgggaggaag atgtgaagaa agattttcat aatgagaaca caaataatac tcaagaatcg 388081 gcaccgaaca cagatgatcg tgataagggt tatgaaggaa acgaagcttt gaaaaagtcc 388141 gaaagttgta cagccgcgga cgagaggtcg tactctgaag aaacttcaga agatatcttt 388201 cacggacacg acaaacaggt agttgaaggc caaaatgatt tcactgggaa aaatattgag 388261 aatgaaagcc agaaattaat gggggaaggg aatcataagt taccgttgtc tgccgaagct 388321 gacattatag aacctggtaa ggatattcaa gatcaagccg aggatttgtt tacgcagagc 388381 agcggagact tgggagaagt tttgccatgg gaatctactg ataaaaacgc tgatgtaacg 388441 agcaaatccc aagagaaaca tgaagattta tttgctgctt ctggaaacga tgagaaactt 388501 ccttgggaag tttctgacgg tgaagtatca tcgggaaaga cggaaaacag catgcagact 388561 agtactgaga aaatagctga gcaaaagttt tcgtttttgg aaaacgacga cgaccttttg 388621 gacgacgacg acagcttttt ggcttcttct gaggaagaag acacagtacc taataccgat 388681 aatacaacga atttaacctc aaaaccagtt gaagaaaaaa aggcttcaag atataaacct 388741 attatcgagg aggaagcagg aatgcgtcaa gagcaagttc attttaccaa tactactggc 388801 attgtaacac cgcagcagtt ccacggtttg actaaaactg gactaggcac ccccaaccaa 388861 caagtcagtg taccaaatat agttagtcct aagcctcctg tggtaaaaga caatcgttca 388921 aattttaaga taaatgagga gaaaaagaag tctgatgctt acgattttcc actggaaatt 388981 atttcagaaa gttccaagaa gggtcacgca aagccggttg ccgttcctac tcaaaggttt 389041 ggctcaggga attcttttag ttctttggac aaaccaattc cacagagcag gaaaggctct 389101 aataactcaa ataggccacc cgtgatccca ttggggacgc aggagcctcg atcttcgaga 389161 actaactcag cgatctcgca atctcccgtt aattatgctt tccctaaccc atacaaaatt 389221 caacaactac aacaggctcc tatccaatca ggtatgcctt taccaaatac caacatacct 389281 cccccagcat taaaagtgga aaccaccgtt tctgctcctc caattcgggc aagaggggtc 389341 agcaatgcct ccgtgggaag ttcagcgtct tttggtgcta gacatgcaac acagtacggc 389401 ctcaataacg gggtacctcc ggtttcgcca tatggtcaag ctaccataaa tttgccaact 389461 gcgaataagt atgcccccgt ctctcctaca gttcagcaga agcaatatcc atcagttgtg 389521 caaaaccttg gcgcttcggc cgtaaatacc cccaattttg taaagaccca tagaggccat 389581 acaagctcta ttagttcgta tacaccaaac cagaatgaac acgcctctag atacgcaccc 389641 aactatcaac aatcttatca ggtgccatat acctcacaac ctgttggtcc tgtagctggg 389701 aattcaagct atcaaagcca aacccgaagt tcttatgcag ttcctatgat gccccaggct 389761 caaacttcag caagtattca gcctcacgcg aacattcaac cgcctactgg cattttacct 389821 ttagccccct tacgacctct agacccctta caagccgcta cgaacttgca accccgtgca 389881 agcaacataa cggctgcaaa ttcactacct cttgcaaatt tgccacttgc tgaaaacata 389941 ctgccagaaa ttatcacgca tcgagctaca agtagtgttg caccaccacg acaggaaaat 390001 aatccaatta aaatagacaa cgaggcttta ttacgccgtc aatttccgat ttttcattgg 390061 agtgctgcaa acaaggtcgt gtacgcagtc ccccctatcc ctgaccaatc gcagtacatg 390121 atttcatcaa gcattgtaca ggaaataaaa gtgacaccaa ttgaccagat aattaaaccg 390181 aacgatatgc tcaaaagctt cccaggtcct ttgggtagtg ccaaattaaa aaaaaaggat 390241 ttaaccaaat ggatggaaac cactattaaa tccatatctg aaaatgaatc atccactgat 390301 atgactatat ggcaactatt ggaaatgaaa ctaaacgata aagttaactg gaaaaatatt 390361 tcaaaactac tatacaattc tgacgaactt ttaatgtacc tatctcagcc ctttccaaac 390421 ggtgacatga ttccaaatgc atatagactg gatataaatt gtcagatgag agtcctggcg 390481 ttcttacaaa cgggaaatca cgatgaggca cttcgcttag ctttaagcaa gagggattat 390541 gccattgcac tattggttgg cagtttaatg ggtaaagaca gatggtctga agtcattcag 390601 aaatatttat atgaagggtt tactgcgggg ccaaacgacc aaaaagaatt ggcacacttt 390661 ctgctcctta tctttcaagt atttgttggt aactccaaaa tggccataaa aagtttctac 390721 actaataatg agaccagtca atgggcatcc gaaaactgga agagtatcgt tgcagctgtt 390781 ctgattaata tcccagaaaa taatgaagat ccactactta taccacctgt tgtccttgaa 390841 tttttgatag agttcggtat attcctcacc aaaaagggct tgacagccgc agctagtaca 390901 ttatttatta ttggtaacgt accactttct aatgagccag taatggcaga ttcagacgtt 390961 atatttgaaa gtattggaaa catgaatact tttgaaagca ttctatggga tgaaatctac 391021 gagtatatat tctcgtatga ccctaaattc aaaggatttt catctatttt gccccagaag 391081 atataccatg catctctttt acaagaacaa ggtttgaaca gcctggggac aaagtatact 391141 gattacctca gttcctcagt tcgaaaactg cctaagaaag atattttaac aataaacctc 391201 actcgtgaat tgagtgaggt ggctagtagg ctttccgagt ctaatacagg atggcttgca 391261 aaaccaaaac taagcagcgt atggggtcaa ttagataaat ccttcaataa atatattggt 391321 ggcgatgata ttgatgcatt gaataaaaaa aatgataaaa agaaagtttt tgatgggttc 391381 acaccgggat cttctgccaa ttcgtcaact gtggatctca cccaaacatt cacacctttc 391441 caagctcaag ttacttcgca aagctatgtg gatactacag ctcttttgca taatgcccat 391501 aatgtaccaa gccatagtgt gctgcattca aagccttcca atgtgtcaaa ggggttagtt 391561 gaagcaaact taccgtatac gcataggatc ggtgatagtt tgcagggatc tcctcagcgc 391621 attcataata cacagttcgc tgctgctgag cctcaaatgg cttctttgag aagagttaga 391681 acagaccagc atacaaacga aaaggctttg aagagtcagc agattttaga gaaaaagtct 391741 acggcctaca ctccacaatt tggacagaac catagcgttc caatggaaaa gtctaattcg 391801 aatgtgccat ctttatttgc cgacttccct gctccaccca aacttggaac agtgccgtct 391861 aattatgtgt ctagtcctga cttagtaaga agggagtcta tcatatctac cggatcagaa 391921 tttcttcctc ctcccaaaat tggggtacct actaaagcta attcctcgca gggatcgctt 391981 atgtactcac caagtgtgga agctttgcct atcgaccctg tcgtcccgca agttcatgag 392041 acgggataca atgattttgg taacaaacat tctcaaaaaa gtatgcctga agatgaatct 392101 cacacatcac atgataatag caatgctgat caaaatacat taaaagactc tgcagatgtt 392161 acagatgaaa caatggatat tgaaggacct ggcttcaacg atgtgaagaa tcttcttcct 392221 atggagccca accaccagcc tacgtctaca gtaaatccta tacaaactat tagtgacgat 392281 atccaaccga ttcttcaaac taacgtggag gtccggggta ctgatgcatc gaaaatggaa 392341 aattcacttc cctccattga aaatgaaaga agtagcgagg agcagccaga aaacatttca 392401 aaatcagcat catcagcata tttaccatca actggtggat tgtcactcga aaacagaccg 392461 ctaactcagg atgaaaacag tatctcagag acagttcaat ccacatactt gccagcagga 392521 agtatttcaa tggaagctaa accaatttct caagtgcaag atgttccaag aaatgttaat 392581 aataaagcat ccaaacttgt ggagcaacat atggcaccac caaagccaaa aagtactgac 392641 gcaaccaaaa tgaactactc accatacgtg cctcaatcaa ctgccgctag tgcagatggc 392701 gatgaatcaa cgattctgaa aacatcgcct gctatatatg caagaactca ccaagcacat 392761 gcatccaatc catcacaata ctttcctttg gtcaaccaag caaatgaaac tgcttcattc 392821 gaattatctg aatcaacatc ccaggcacaa agtaatggaa atgttgcttc agaaaataga 392881 ttcagcccaa taaagaaagc cgaagtcgtc gagaaagaca cttttcaacc tactattagg 392941 aaggcttcaa ctaaccaata cagggctttt aaaccgttgg aatcagatgc ggataaatac 393001 aatgacgtta ttgaagatga atccgatgac gacaatatgt ctactgatga ggcaaagaac 393061 agaaaggaag aaaaaaagaa tgtgaatatg aaaaaggaaa caaaaccaag taacaaggac 393121 atagatgaca agtctaatgg ttggtttggt tggttgaaga aagatactgg cgacaaaaaa 393181 gtgtataagg ccaagctagg tcataaaaac acactatact atgatgaaaa attgaaacgt 393241 tgggtgaata aggacgcaac cgaagaggaa aaacaaaaaa ttattgaaag ttcggcacca 393301 ccacctcctc caatcgtgaa acgtaaagat ggcggcccaa agacaaagcc acgttcaggc 393361 cccatcaata attccctacc tccagtacat gccacatcag ttattccgaa caatccaatc 393421 actggtgagc ctttgccgat caaaacatcc ccttctccta caggacccaa tccaaacaat 393481 tctccatcac catcctctcc catatcaagg atttctggcg taaacttgac tagcaaaaag 393541 gcaaacggtt tggatgattt attgagtttg gcaggaggac ccaaaccagc aagtacgaga 393601 aggaagaaga aaacagcgag aggctatgtt aatgtaatgg ataacataca ataattatag 393661 taatacgttt ttctttcatg gtacccttat gccttccctt ttcttgatgt atattatata 393721 cttataaaaa ccgtagtaaa ttttattaaa acaatgatta caggaatccg tatttaggtt 393781 atgcatcgtt gtcagtaaga aatcagatga atgcgatctg aaactttgct tatactaata 393841 ttattctatc atacctcatt ttcttgcttc gattaatgca ggacgccggt tccgggttag 393901 gatcaccgag aaacagaaag caagcaaggc ttcagttaca attcgaagaa gtactaaggg 393961 ggttgtcgtg gaaaaatctt gaatcagaaa gcggctgact ggagcattac taggttcatt 394021 actcactggt tctactcatg aaaccttact tatttgacct aaagctaaaa gacacagaga 394081 agctggattg gaaaaaaggc ctctcctcat atctcaagaa atcatacggc tcctcacaat 394141 ggagaacatt ttatgatgag aaagctactt cagaactgga tcacttaagg aataatgcaa 394201 atggagaact agcaccttct tcattgtcgg aacaaaatct aaaatattac tcatttttgg 394261 agcatcttta ttttcgcctg ggtagcaaag gatcaagatt aaaaatggat ttcacttggt 394321 atgacgcaga atactcatcg gcccagaaag gattgaaata cacgcaacat acgttagcat 394381 ttgaaaagtc ttgtactttg ttcaacattg ctgtaatctt tacccaaatt gcgagggaga 394441 atatcaatga ggactacaaa aactcaatcg caaatttgac aaaagctttt tcctgttttg 394501 aatatctatc agaaaatttt ttgaactcac cttcagtcga tcttcagtca gaaaacacta 394561 ggtttctggc taatatttgc catgcagaag ctcaagaatt gtttgtcttg aaattattaa 394621 atgatcaaat atcatccaag caatatacat taatcagtaa actttctaga gccacgtgta 394681 acctctttca gaaatgtcac gattttatga aagaaataga tgacgatgtg gccatttatg 394741 gtgaacccaa atggaaaacg acagttactt gcaaactgca tttctacaaa tcgttaagcg 394801 cttattatca cggtttacac cttgaagaag aaaatagagt tggcgaagca attgcttttc 394861 tcgatttttc tatgcaacaa ttgatttcat cccttccatt caaaacgtgg ttagtggaat 394921 ttatagactt tgatgggttt aaagaaactt tagaaaagaa acaaaaggag ttgattaaag 394981 ataacgattt tatatatcat gaaagcgttc cagccgttgt gcaggttgat tccattaagg 395041 cgctcgatgc aataaaatct ccaacatggg agaagatatt agaaccatat atgcaagatg 395101 ttgcaaataa atgtgactct ttgtacagag gaattattcc cctagatgtc tatgaaaagg 395161 aaagtattta ctcagaagaa aaagcgacgc tgttgagaaa gcaagttgaa gaaactgaga 395221 cagcaaattt ggaatattct tccttcatcg aatttacaaa tctacccagg ctcttgagtg 395281 atttggaaaa acaatttagt gacggaaata ttttctcgaa tacggataca cagggacaat 395341 tgatgaggga ccaaattcag acatggtgta aatttatcca aacaaatgaa tttagggata 395401 tagaagaaca gatgaacaaa attgttttca aaaggaaaca aattttagaa atcctttctg 395461 ccttacccaa tgatcaaaaa gaaaatgtta caaaactaaa atcttcttta gtagctgctt 395521 caaactcaga cgaaaaattg ttcgcatgcg taaaaccaca tattgtcgag atcaatctat 395581 tgaatgacaa tggaaaaata tggaagaagt ttgacgaatt taatcgcaat acgcctccac 395641 aacctagcct attggatatc gatgatacca aaaacgacaa gatattagag ttgttaaaac 395701 aagtaaaggg ccatgcggaa gacttaagaa cattgaaaga ggaacgttcg agaaatttgt 395761 ctgaactaag agacgaaatc aacaacgatg atatcacaaa attattaatt attaataagg 395821 ggaaatccga tgttgagctc aaagatttat tcgaggtgga actggagaaa ttcgagcctt 395881 tgagcacaag aatagaggcg acaatttaca aacaatcttc aatgatagat gacatcaaag 395941 ccaagctaga tgaaattttt cacctttcaa atttcaagga taaatcttct ggggaagaaa 396001 aatttttaga agatcgtaag aatttttttg ataagctgca agaagcagtg aaatcattca 396061 gtatttttgc atccgacttg ccaaaaggaa tagagttcta tgattcatta ttcaatatga 396121 gtagagactt agcagaaaga gtgagagttg caaagcagac cgaggattca acagctaatt 396181 ctcccgctcc tcccctccct ccacttgatt ctaaagcgtc tgtcgttggg ggtcctccat 396241 tactgcccca aaaaagtgca gcctttcagt cattatctag acaagggctc aatttagggg 396301 accaatttca aaatctcaaa ataagtgccg gcagtgattt acctcaagga cccggtattc 396361 caccaagaac ttatgaagct tcgccatatg ctgcaacgcc tactatggca gccccaccag 396421 taccaccgaa acaatcgcaa gaggatatgt acgacttgag aagacgtaaa gcagttgaaa 396481 acgaagaacg tgaactgcaa gagaatccta cgtcctttta caatagaccc tctgtttttg 396541 atgaaaatat gtactccaaa tacagcagtt aggtgcattt cttatttctt aattttattg 396601 tagctttttt ttttcaacta atatgataat tatatatata ccggatttgt tgaaagccag 396661 ttttgcaagg ataaagaaac tgcgatttag caaaagtccc tttaatgctt cttccatctt 396721 tgatctactt tcttttgagt attaggtgta taccatacac tttcagatcc aaaatcagcc 396781 tcggacattt ttacaaacga aataaggcca ttatccataa tagcgataat aaagctccga 396841 tatcccgtct tcaatctacg attttgctgt atgtgaggtg ggtacgcctt tctcttcttt 396901 ttcgtgctag actgtgcagt ttttttttga aaacttgctt tcatagacga ctcacttttt 396961 tcagtttgag atttcgcgct cctcttatga atatattcct ttcgtgggat atcttcaacg 397021 taggagtttg tctcccaatc gtcatcatcc tcgatttcgc ttaaaaattc gaatttataa 397081 tcaagtgagg aaaacataga tcgcagctct ttataggtag gaaaatgctg aagatcgtca 397141 tttttattgt aaacgaaaac ttggaaatca ggaagaccgg ggtctctttt cttgaaatta 397201 gaatggggtt tccatacttt aaatgtcaag ggaatatcct ttaccttttg aaattcccta 397261 tcagattgtg catccaatag ctctttttta ttctttggta cagccacgga acgaacaagc 397321 ctatttaaac cctggtataa ctgtggtgaa gtcgtatatt tacgaaaaaa aaaattccac 397381 ttagaataga agaaaccact aaacagcgat aactcttgta ttttaaacaa tgaaagtaat 397441 ctccaagtga ttgcttgtaa attacttcgt tgctttttca atgggaaaaa ggaagtcttg 397501 actgctgctt cttgattgct gggttttaga ataaaaccca acctttttaa atgagcaaac 397561 acaaaatatt ggtccatttc ctgttgcgat gaaaacagcg aatacaaatc ctccatactg 397621 agtaaaatct ctgtttcgtg ctttgagctt ttgttagagc ctgcttctaa tctataataa 397681 ggaagaatag tgcctctctc tgccaaataa acaaactcat ggaagtcaag ccagagttcg 397741 cctgtgctat cagcccttcc catcgtttgc ataaagctgc ctttgggttt aagtagaacg 397801 gcttgatgtt tatggggaac atagtatcct cttacttcag attttactgt tgtgcctctt 397861 attgagtctg atatggtatc aaacatggct ttacttgcat tatagagaag cagatcttgc 397921 aaattagtcc catctggttc atagtctttt tcacccctct ttggaagtga aagagcagca 397981 tttttgctaa cgagcgatgc gagttgcgac caatcttgtt gtagttcttc ttcttcttct 398041 tcttcttctt caaagcccgg attagatgtg gtcacttgat cagttttctt cccagcgaat 398101 tgcatttaaa ttggcagaag aacagaggtt ttatgtatgt ttatatccaa acgtttcgat 398161 agctcaaatg aataattttt catactgaga tgaagctctg cagagttcga ctaaactgtt 398221 tctagtttcc ctttggcgca acttaactat gaaaaataat aaaataaaaa aaaagtccaa 398281 gccataatca atagacagct aataacctga attttaacaa gagaatatga aaacattatc 398341 aatactgatt tgaatatacc cgtaaattct ataagactcc attaatatac cgtattatat 398401 tacaagttga taatacataa atgcgttaaa taaaacaaaa atgaccttgt atacgcgtca 398461 ttccaatgca agaatttgtt tatcgtaaag ttttgatgaa ggtgtctaaa ttatactcct 398521 cctcgtattg agatgggtcc catagctctt tcaattcacc gagggcctct ttggctttgc 398581 cagttaaacc agtctcgttg gcaatatctt ccatgccctt ggctgcttgg gaatcgccat 398641 tattcttttc ctcattgtcc tgtgaggtaa cgttatcggg gtcgaagaga tcaagcagct 398701 gatgtgtatc catggatgct aatccactgt tttgctgatt aacaactgta gaagctatat 398761 tcattttgaa tttctgcaaa cccatgattt tttcttcaag cgtacctttc gtaataattc 398821 tgtaaacatt aacaaccttt ttctgaccaa ttctatgtgc tctgtccatt gcctgtagat 398881 cattcattgg attccagtca tgctctacaa aaatgacggt gtctgcacca gttaaattca 398941 gacccagccc tccgaccttg gtggtcaaca gtaggcaatc aatagaggga tcttcgttaa 399001 atttccgaac aactttttgt ctgtctcttg ggtcaatgct tccatctagc ctcatatagg 399061 ttacggaggg catatacttt ttaaacaagt cattttcaac catgtctagc atatctttta 399121 gttggcagaa aatcagggct ctgtgttgtg atatgacatt ttgaatagga aaattctgat 399181 cttggcttgc ttttttgtcg atatcttctt cacctatacc acattcaaag agtaatgttc 399241 tcaatgcgct cagttttgga gcgttgataa tatcgtgtaa atctagacca gtttgcttta 399301 aatagtcttg tacttgcgct aattgcgggt gatttggtga aaggaccaaa gctggatgat 399361 tacacaattt tctcatgtat tgtaaagctt ggaaaatatg ttgcttgcca tcagcaatct 399421 cagaattttc aatatctttc tcaactacat ttttttgttt tttagtaaaa tccatgtata 399481 gttgtttttg taaatcacct aattcacagt agtaatcctg aataatttta ggtggtaaat 399541 cagatagaac gtcttccttc aatcttctca gcatgaaagg tagaacttgc ttatgtagtg 399601 cctccaaagc cagtacacct gcttcctgct ccttagatga tgttttacta tttcttgacg 399661 cagcgattgg ctttgcgaac ctttcctgga acatcttttc cgttcccaaa aatcccggca 399721 ttaagaagtc aaacagagac cacaattcta aaacgttgtt ttggatggga gttccggtta 399781 aaattaatct atggtttgca gtaatttctt taacagcctt agcaagtttt gattgagagt 399841 ttttaattat atgtccttca tccaaaacac aataattata ttcagttttg tttaggactg 399901 cgagatcatt tctagctacg tcatatgatg ttacaataat atcagcatca cttaactgtg 399961 gtctcagagt taatctgaca gttgggccac cggcatacac aacaaccttt aaaaagggag 400021 catactggtc aaactcgttt tcccaatggc cagttaaaga tggggggcat attatgagag 400081 atggtaaggc tctactttca acagaacgcg ttttttcata atcttccttc ctcaaatatt 400141 gatcgcttgc gataatgcag atggtttgta atgttttacc caaacccata tcgtcacaca 400201 atattccatg tagatgatat ttgttcagga atgccaacca gttaacacca tcttgctgat 400261 attttcttaa agtcgccttg atggcaatgg gtaatttaaa tggcttagct ttagaaggat 400321 ccatcatttg ttggataaaa tcacgctccc tctctctgct tgccactagt tcttctggga 400381 gtccttttgg atcggcgata ccagcttcta aaggaactaa tttgatgata gaagcaaatg 400441 ttgttgtagc taaattcctc acatcttcgt tcgaatcact catgcgaccc aaaagtggaa 400501 ctattaagaa aatgacgtaa ggtagaacat cggtttccat agaaagtgat aaatgataaa 400561 taagctccgt ggacccttga cgatcggata gagaaccagc gctattcatt aaaggcaaaa 400621 tctcacgtat ggtgtaagcc attacctcca cggaggaaat tttagccaga tcagcaaaag 400681 ttcttgcagc tgaataacga aaaacagata agtttgatct taagaacgtt aataaaacag 400741 ggaaacgggt aaaaacctca ctagaacgta gcgaatcaga cataaatggg aatagagctc 400801 ttagtacacc aaatgagtcg actatttttt gaccttgctc gttgtcaact ttacttgctt 400861 cctcattttc atgatcagat aatgaatcaa ataaaatcga tctaagctga ggtagtttct 400921 gtaatataga aggcccaaga acttcaaata gtatttttaa cgtaatcaac ccacccttcc 400981 tttttagttg agcctcttcc gacatctttg cgagattaat gtcatcttgt gcggcaatcg 401041 aattagattc ttttattaac gtcaatattt tttctttata ttctgcattt acggagaaat 401101 caggaacttc tgaagtatca acgcataaaa atccgcagag atttttgact atcttaccag 401161 acacattaac tttattattt tctaacagtt gctgaatcaa atgtacgacc gattctccgg 401221 ccatcgtttg taacttttca ttcctttctt ctttaacact gtccattagc gacctgataa 401281 tggggtttaa tttaagaggt agaccatcaa ataacaagat ggatgatgcg taattagcga 401341 gaatgctgcc tgtacgaagt tttgcggatt ctttggctga attgattgcc atcaacacgc 401401 gatgcttaga atcttctaat ggcttcttgg ccaatagttt gtaagagttg ttcatggatt 401461 tgaacatttt atcatagtat tcgccgtaca ctttttctgc tgtttcaaca ccaaacgcat 401521 gtggaccggc ttctgtttcg ccttgaacca caattgctac gttgggtagt ttgtactgag 401581 gtaacatacc tacatccaca aaggtagcca gtaggctttg acattgagtc ctcagagctt 401641 ttaagctagg tactagctcc ctaaatacag gaaattcatc gcgattcagt aactgtttat 401701 tcatcacagg actgaaaatc tctgatacaa aagaaggtaa tttttcccct tctggatgct 401761 tttgtaacca cgaggagcaa aactgtgaaa caataatgcc tgccaacata cgtggagttg 401821 agaatggcag ctctaaacaa cgaaccagaa cgtttgtgaa gaaggattga agcgtggaat 401881 cttgaaacat tgacaatgtc aaagcaaatg cctttgctcc cattattcta gtgttcaata 401941 ttacgtccaa tcctagcaaa gtaatatctc cagcaatcat aggtgcatcg atattgatat 402001 gttcattatt ttttggtatt ggaatgtcag aatctgttgt ggtttcagat atagaacgtt 402061 ttttttctgg atgtaattga tagtgctggg aaggctttag aatatattgt gattccatgg 402121 cataattctt tcccttttcc cctactggcg tatttagaag atgtagtatt ggctgcaaat 402181 gtttactgaa aacatgatct aaagtttttt cggtatgctt aactttataa tgctccaata 402241 acgcaacata aacatcaaaa gacagttgca atagttccgg gttttgctcc agtaaaatat 402301 tctgaaaaac tagacggaat accttgccgt ttaaccagtt tttagtagaa tcatccttta 402361 ttgataagaa tgcaatcagt agattcaaaa cagccctcct cacagaagaa atcgaatggc 402421 gtaaaaaggg atacaatttc ggtaccagtg acttgaatga ccactctgaa ggatgctcta 402481 aagccttgtt ctttaaaata tctagtactt cttggtggtc gcacaacttt gccaatagat 402541 ccattataga acctacgctt gaagatatat catcatctaa acgagctagt aatgaccata 402601 tcgtggtcac caaaatttct atggtagagt tgtttaattt gacaaattcg ctggttattg 402661 gggttaaaat tgaggctgct acgctttgaa cgtcatcatc actttggttt aaaccatata 402721 gcactatacg gacaacgttt tctaaaaggc catgggcaaa taggaaattt gtctttatgc 402781 tgacgaagta acgaatccct aaaagccctc catgggtagc ttcccatatt ttgttcggta 402841 gacctgtttg tagtggatct tgtagaacca gttgttctaa acaattaaat attttaattg 402901 ataaggtact gtctaggtga attaataacg cagctagagt ttgcgcaact gactctcgta 402961 caggggccac aactgtatca taaacataat caccaaatct atccaatgca aatactgtaa 403021 gtagacggga cgccaagtct tctaagcttc tagaattcct caggttgttc tcctctcggg 403081 tattcccctt aaccctgctg actccataag catgtttttt taccaattct cgaagaccca 403141 acgcagctcc atgccttatt tcccaatttt cgctcattag attatctaaa agtagttcat 403201 aaatgccttg gaattgccaa actaggccag caacaatttc gtgttgttct agcaatggcc 403261 ttactgtgga ttctatcatt agtttacttt catcggcttg ttcagtaatc tccagtttgg 403321 gatttagctg gttactggtg ggagaagtgg ctagcgatgc agcagaattg gtcatatttt 403381 ttccatttaa taaagtcttg gaaactgaac tttccgttat atctacagga tgtttgggag 403441 tattcttagc actcattttc ttttttcgcc ttgccatagc aagcatcctt gctgacttct 403501 tgttagcatt acttttattt tcattcgcct tatcagacgc atttagcata gatgtttcct 403561 gttttatatc atcagtttta gcttgttttc ttatattatc gtcagcctta ccaagaacat 403621 tgtaatcatt catactcgac gccaggagca ctttacctga ctttaaaatt tcgttcaatt 403681 tccaatcaga cagagaactg aggtgatggt cctcctgtaa gagattcaac tgattgttct 403741 gagtagcctc ttccaatttt attttcattt catgttccaa cttcacctga gcattatcca 403801 atggagaacc ttcatttgta ccacctacca agtcagattc attcggatcc caagaaggag 403861 catgggcaac tatgccaccc acagctcttg ctgcagtaac acgcgtttcc catttcttca 403921 ctagtaaaaa ggggtaaact ctggacagca acgaaagaat gtcttcgggg tgctgtttgg 403981 ccaagtctcc catttgatcg gcagccatgt tccggactac ttgggtggaa ccggtctcta 404041 ttaatattac ctgccggtcc agcctcgaaa ctcgtgacgt catttgaggt gctgtgtgtg 404101 ttgtgatact tttgttcgtt aatattggaa tacgatcgct acttatattt tatgttctga 404161 aggactctaa aagcaaatca aaataaccgc cgagctgtgt gttcagagct ataatagcag 404221 aatggtggtt tttttctgag cgcaatagaa aatggcgcgc aaaccgccaa gggaacggaa 404281 ttggtggaaa tcataagctt ttatatcaag tgcagcggcc ggcgagtggg acgtgctttt 404341 tttacttttg ggtttttgcg atgaggcggt agacgcgttg tctttgcgcc tggggcccgc 404401 cgtccaacgt gcgggtaccg taccctgcag tgttgcaatc gtgtacttgc cttatagtgt 404461 cagctattga tcaaggccac atgcaaaata gggaaggggg gcattggcac aaaagagtgg 404521 ttagacgctc acaggggtga ctacggttac aagtctaaat attttaagcc catcattacc 404581 ggcaatgccc tctgtacagg agttataaga aagattattc aatttcgcgc ttgcattatg 404641 aaagaggttg cattcttcaa tatcaggtga aatgtgtctt gcctagacaa tctaaaaaag 404701 gctgcacacc catgcatcat tctaaaaaaa ttattttttt tcttttcatt tacttttcgt 404761 tttttttttt ttttttttca gttcgatttc ttggtcggac gcgatggcaa atttttcatc 404821 gagagattat cgttataaag gcctgttgat tttcaaagag atagaaatct tctcttttaa 404881 gtattctttt tttaattaat aaaaacacaa gaaaactaat acagcaacag aaatacaaaa 404941 gtatacaaca tgccaagtac gtcgttaatc ttctcctttt aaggggttga gaatattttt 405001 attaaaaaat catacttgct atgattttga ggatcgggtc ctcataaata ttttgaagag 405061 cctttgttga atttttttct tttcgttttg ttcaataatg gacggttctt catagaatac 405121 tttttttttc ggagaaaacc tttacactga actcccgaca cttcaggtaa agcgttccga 405181 agtaattcaa cattagaaga ggaacatttc cccagttctg attatgtctg ttgaagataa 405241 ctcaagtatt ctaggcttaa tacagaaatg tgttaggttt gagaactcca tcatggatta 405301 tgcatattcg tcagtgacgt gcacaattct tttgaagata ggaagaacaa aacttcaata 405361 attgctttaa taatatttat gtagtgatct tgatcctcgc attcgtttga aaaagagagc 405421 gctcactaac aatggttgta attatcttgt aaaacaggag ccccaagaac atattccaag 405481 acttactcta ccccaaagag accttacgaa tcttctcgtt tggacgcaga attgaagttg 405541 gccggtgaat tcggtttgaa gaacaagaag gaaatttaca gaatttcctt ccagttatct 405601 aagattcgtc gtgctgcaag agacttgttg acaagagacg aaaaggaccc aaagagattg 405661 ttcgaaggta atgctttgat taggagacta gttagagtcg gtgttttatc cgaagataag 405721 aagaagttag attatgtttt agccttgaag gtcgaagatt tcttggaaag aagattgcaa 405781 actcaagtct acaagctagg tttagccaag tctgtccacc atgcaagagt tttaatcact 405841 caaaggcaca ttgctgttgg taagcaaatt gtcaacatcc cctctttcat ggtcagattg 405901 gactctgaga agcacattga ctttgctcca acatctccat tcggtggtgc tagaccaggc 405961 agagttgcta gaagaaatgc tgcaaggaag gcggaagctt ctggtgaagc tgctgatgaa 406021 gctgatgagg ccgatgaaga ataattgtgc tgatttttat ttcttaatta cgtgttgaaa 406081 tcacgatact ggcatccgat aggggagttg tattcacaat actatcgatt ttgtaaaata 406141 ggacgaagaa ctttttatat acgagcattt cctaattagt aggaagcgga aaataataat 406201 ataagaaagt aaacgcaaaa gataggctga ctgccttcat tcgactagga ggtgaggcga 406261 catatttgtc accattcaag ttaccgagat ggtagagagg tggatggctc gggtgagctt 406321 gattgtacac tgcagcaacg atgctttttc tacccatttt atgaagttta acatccgtac 406381 ctttccacct ccaaacattt tttgtaactt cgtcctttga aaaatcaaga agtaataggt 406441 gtgcagtata gggccgcttg agcgcgcaat atcggtgagt gaggtaagat ccatccatac 406501 cttagcaaat atggtagtga ggaggccaac tgtattgcgt taaaggcaaa aggattggta 406561 tatacgaatg attggtaatt tgaaaagtag gtttcgaatc aaagaaactg agacagtcaa 406621 ggacactaaa caaaaatggg taaatcgtat gtccatataa cttcaaaatg aaaatatagc 406681 agttgaaaca tatcaattaa atcattatac atctccaata aacatgtatg caagaggaaa 406741 gcgtaaatat cttcgatttc gacaatactt tgctactgaa ctaaaaatga aaatgaagtt 406801 gaattctcaa aggaatgtga tgcaagttcg ttaattaata tggtttttag tggaattatc 406861 atagtttgtg atagatacac acgaggagta gtgagcaaag caagtgcaac agcaatgata 406921 tgttagcagg aaataatatt ataaattgga tattgtgtgt ttttttgata tatgtttgtc 406981 gaagctaata cagaatgatt actaactgga atttaaaagc acaatcatgc tcttggatga 407041 ttgatctatt aaaaaattat aaaacagaca tggttacaga tctcgtacac gttacatgtt 407101 ccaacgtgac ttcagaaagc atggtgccgt tcacatgtcc acctacttga agatctacaa 407161 ggttggtgac attgtcgaca tcaaagccaa tggttctatc caaaagggta tgccacacaa 407221 gttctaccaa ggtaagaccg gtgtcgtcta caacgttacc aagtcttctg ttggtgttat 407281 catcaacaag atggtcggta acagatactt ggaaaagaga ttgaacttga gagttgaaca 407341 catcaagcac tctaaatgta gacaagaatt tttggaaaga gttaaggcca atgctgctaa 407401 gcgtgctgaa gccaaggccc aaggtgttgc tgtccaattg aagagacaac cagctcaacc 407461 aagagaatcc cgtattgtct ctactgaagg taacgttcct caaactttag ctccagttcc 407521 atacgaaacc ttcatttaat ctacctcgtt tggtatattt atcgaagtta tcacattcct 407581 atatattgta tcctttacat aagaattgcg tatagataga tactataaca atttacatga 407641 tattatttga ttaaggtgca tattaccatc ttctcagcag gtattcaaac atatctgcca 407701 atgtatgacc ttgacatatg tgaagagatt actgtggaga agaatagatg tagcattgtg 407761 cgcacttatt aaatctacta cttaaaaaaa tgtgtgaagt ataaagtgaa tctaagaata 407821 tttgtagtat ttaaaacatc aatgtctgta caagaagaga tatataacct gagcatcctt 407881 tttcagatag tgcacttcat cgttatcaaa ctgaactcat aaggcgccat ttttttaatt 407941 ttttgccttt ccgtattgtt tttcttttcc tttccttttc tttcattctt gtcgcagtta 408001 ctgttgtgat tacttcaatt tagaaagcaa ttgttcaatt tcagatatag actgttgcaa 408061 aactttctct tggaattttg gattacccaa ttctgactga actctggaga tgacagattt 408121 tgctagttgc ctttgttcca attgacgcaa ggaagcttca tatctaaccc acgaatctaa 408181 gactgccttt gcttcgtgag ctaattctac cttttgtttc aattcaaagg cttcgctttc 408241 aagttcaaca gtttccttgg aaacatcaaa caaaaccttt gtagtttcag caacattttg 408301 tagttgagag acagagtcga ttctatcttt aacagcttcg acatgcttgt ttctcgaggc 408361 atttaaaacg tcggagactt tcttcattct tgcatcggca aaatctttat atgctggcgc 408421 caaatacttt gccactaaac cagtgaaacc caaaaaagtc agcaataaaa tactttcatc 408481 gttgataacg tacaattcat tggaaatggc ataaatgaca gcggcagcag aagtccccaa 408541 aacccccgtc tttgtcaaaa tattattacc tggaatggca ttgatgatag agttagcctt 408601 tgcttttgga tctgtctgtt tttctggagt ggaagacata taacgggctc caatcaccat 408661 cgaaggacaa cgaacacctt ggctaaataa tgttttagaa acggacctta acgctaggcc 408721 acggacaccc atactcatgc tcattttatc tcttgcgcac ttaggaggta ctgaattctc 408781 gtcagtcttt taataaaata taacccttcc tagcacagta taaacttgtc aacataaact 408841 gctaactgca attataatcc cttgctattt taattaccca aacctgtggt gaaggtccga 408901 atgagcggtg aagagaaaaa gcgtcgtgat tggttcaata ttgatgtcga ttacccggcc 408961 aatgaggctc gctcgatggg acacctctat gataatagtt gtcgccacag ccattctgaa 409021 ttatatttat cttttatcta cgtatgtgcc attgtcacag cacatttcta attctgtgtg 409081 aggaactaat ttagccatgg acagtttctc atgcgtggaa gacctgttat gctgtatagt 409141 actgcgccgc gttaaaaaat attcatgctt gtagagtaga atattcctat ctttaccgga 409201 ccgtatttca tctgggagtt gcagttgcgt cacaacacag tttatggcta ttttattttg 409261 aaaattaagc atatatgaca taattagagc actcctatgt gggaattctt acacttttaa 409321 tgtagaatct cttggtgatt gttactatca gttgtgtttt ggccctacta ttgtaattcc 409381 cttatagtgt tcaccagctc ttgaatgtac tttccttctt caggatcaac ggttggtcca 409441 tttggatttc taattgcgct gctactatgc atgttgttgc ttgtagcttc atctccgacg 409501 gattttcctg ttggtgatgg cgttctagtc atcatggcag cagcggttgc gaccgccact 409561 tcacgacgtt gttcctcttc tattttagca ttgcggtccc tcaagacttg aagtagttta 409621 ctatgtgctt gccttaattg catcagtttg ttctcgaacc ctggaggaaa ctgatcatac 409681 aattctgttg cctgcgcctg tcttttaacg tcatctaggg catctatttc tctccacaaa 409741 tagtcttgtc tgtcgattat aggccgtact tccagtctgt tatgtgtctg tagcggtata 409801 tctacgctat ttctccggaa tttggcaact ccgttatagc taacactatc ggtatctatt 409861 gtgtcattac caactgtgtt agcacttgaa cggttataat agttattgaa tagactcctt 409921 gtcgaaggaa tttgggaaga ataagatggc ctaaatcctg aatttctaat atagggattt 409981 acatttggta ttgtcctggg aaggtcatgg atgctgtcct ccccataccg ttcatcgtct 410041 tcattcgtga tttgccttcg tactgagctt tttttctgga gatctttcat gaagatagtg 410101 aattgtaaat ttttggttag gtttttcaaa aacaatgtca attacatgtc agcgaaggcc 410161 aggtagtagg tgtccgtggc tattgattat cttgatatcc gaacttgaga ccacttcgcg 410221 gctactaaat ttatgaacta aaaatgaaaa tttcaacttt ccattacctc ttcgctttaa 410281 accaatttaa aggtacaatc acactttaag tattgttgtt agacggtggt gaatataatc 410341 agaggcatcc aaactttctg ttgcaggtcc attatcctct caattttcgt atgaccttaa 410401 agagacttca tagtttatat ttggttattt tcaataggta caatgacaag atctccctgg 410461 aagcgcctac tatggttgaa acaggagtac ccagataatt atacagatcc aagttttatt 410521 gagttgagag caagacaaaa ggctgagagt aaccagaagt ctgatagaaa attatcagaa 410581 gctgctcgcg ctcaaattag gttggatttt ataagtttct accaaaccat attgaacact 410641 tctttcattt acatcacttt tacatatatt tactattatg gcttcgatcc tattccgcca 410701 actattttcc tttcatttat aacattgatt atatcaagga cgaaagtcga ccctctattg 410761 tcctcattca tggacgtaaa gtcttcgctg attatcacat ttgcaatgtt gactctctct 410821 ccagtcctca aatctctttc taaaacaact gcatctgatt ccatatggac attgtctttt 410881 tggctgaccc tatggtacat tttcgttatt tcgtcaacaa agtccaaaga taaaccctct 410941 aacctttcca ccaatatact tgtcgccctt gttgctgtcc tatcatcgag gctttcgacc 411001 acaatcgacg tattctgttt tcttttaatt tgtattcagt tgaatatcat tctacccact 411061 tatttatcgg tgacgaataa ggtagtacca ataatttcaa atattattgt atactcattt 411121 ttgaatgttg ctctaggttg gatttatatg ctgttgattt tctttgcttc agtattttat 411181 attactgttt tacctaagtg gttcatctac tggaaaatca attatcataa acgggataac 411241 gatctactaa gtacatggga tgcaagaaca ccaatattgg attagcgcaa tcaagaacat 411301 gatttccttc ggataagcaa gggaggggta cgacttctgc ccgcaggggc ttattgcctg 411361 tcctcttcct cgaccccacg gtatttcatt atatatagag tcactgtaat aataattatc 411421 atgaaacctg acaagcaaag gcgtcgggca attaccaaag ggcagttcgg tcgattaagt 411481 ttgcttcact acagattatt cacatatcat acgacaactt taaaattgaa cattcaggag 411541 atttttgaat gcattgatgg gcccttgcac cttaaccggg tcccaatatt agagaaacgc 411601 ccccttaaac tgaacacaag acaatactac ctggccaata gggtacaatt tgcggccgtg 411661 ttaaacaggc gtttcagcgt ctaccgctcc taatttaaag tcacttgttt cttggtagca 411721 gcagcttcct gttttcttct ttttggcact tggttatgtg ataatatcac ccggatgaga 411781 aacctttaaa ataagcgttt gggaggggaa aaagtgcagt aactgtcaca aatttaacaa 411841 acaatttgtt cacaagtttt gccttatcgt tcatcacatg ttattttttt caatctagcc 411901 aaagtatcta aagaagaatt ttcgtctctc ttgtgccttc tcataatgtt caattaagat 411961 gcagacggct ttgacatgtc attaatttac tgaatttctg acacttcccc acgatattta 412021 tcatttttta cgtaattaag atttaaactc cgtacacccg gcttccacaa atgtagaatt 412081 ttccggagct tcgaacttct tgtttcacga attaaaagca tccaacgtag aaccacccaa 412141 ctcatcttcc taatgctgaa gcttcatcgg taaacaaacc acagttaata gcgagaaagt 412201 cggcaagtga caaacgacgg ttatatttaa ttggcctttg atatatattg aaaatggtat 412261 ggtatgatca taacacgcat tctgaaaatg ttatctggga ggttttcgat gggtatggag 412321 ttttccttga ttctcactta ttatcccttg tattgtaatt gatccttcag taatatttgc 412381 agcctttcac aactatcctt tttttcattg cttattacta ttgaaccttt tttaggagtt 412441 gcctgcttat gcaatataat ttgctgacaa gtagtaaatt accagcacaa tattaagatt 412501 aaaaaagaaa ttagccaaga gcttgatata ttatcttata cacaaacctt tccgacctac 412561 ttgataaagc cacatacctc tacctcttct attagaaata gaaaagtaca aaaatagcaa 412621 aaggaaataa tttctttaaa ataacattgt gtgaggttcc aactatggat tattaataga 412681 gtaacgcaaa cttaaggaaa ggaagtgctt tacaattaag tatttataag aacgaattta 412741 tcccccaaaa aaaagcacct atacttaata aaaggagggg aatagctatc aattgagtgt 412801 tgtctgcgtc tgtctgcgta caagaggatg aattttctga ctcaggctat gtcagaaact 412861 tttcaaggga caaataacag gataaaacgt aatgtcagga cacaaagtgt gccatcaact 412921 tcctataata atggcaaaga atcatatgga ccaaatacta accaattaaa tgccctactt 412981 tctcaattgg aacagcaaac aagtgttgat agtaccagca cgagctcaaa cttttattcc 413041 attgcacaat atattttaca atcatacttc aaggtcaatg tagattctct aaactctctg 413101 aaattggtgg atttgatagt ggaccaaact taccctgatt ctttgacgct gcgaaagctg 413161 aatgaaggag caacgggaca accatacgat tatttcaata cagtttctcg tgatgctgat 413221 atctccaagt gtccaatttt tgcgttgacc atattttttg ttatacgatg gagccaccca 413281 aaccctccaa tttcaattga gaattttact acagtaccgt tgctagattc aaactttatt 413341 tctctaaatt ccaatccttt actatatatt caaaatcaaa acccaaacag caattcaagt 413401 gttaaagttt caaggtcaca aacgtttgaa ccttctaaag agttgatcga tttggtattt 413461 ccatggctgt cttatttgaa gcaggatatg cttcttattg ataggacgaa ttacaagctt 413521 tattctctct gtgaactatt tgaatttatg ggcagggttg ccattcagga tctccgatat 413581 ctgagtcaac atcccttatt actacccaat atcgtaacat tcatttcaaa atttattcct 413641 gagttattcc aaaacgaaga gtttaaagga atcggttcaa ttaaaaattc aaacaataat 413701 gccctgaaca atgttacagg aatagaaacc caatttttaa atccatctac cgaggaagtg 413761 agtcaaaaag ttgattctta ctttatggaa ttatcaaaaa aattaactac agaaaatatc 413821 aggttaagtc aagaaataac acaactaaaa gcagatatga actccgtagg caatgtttgt 413881 aaccaaattt tgctgttgca gagacaattg ctttcaggaa atcaggcgat cggatcaaag 413941 tccgaaaata ttgtgtcttc cacaggtggg gggatattaa tactagataa aaatagcatc 414001 aattcgaacg tactgagtaa tttggttcag tcgatagatc ctaatcactc caagcccaac 414061 ggacaagccc aaacacatca aaggggtccg aaaggacaat cacatgcaca ggttcaaagt 414121 actaatagcc ctgcgctagc gccaattaac atgttcccga gcttaagtaa ttctatacag 414181 ccgatgcttg gcaccttggc tccgcaaccg caagatatag tacagaagag gaagctaccg 414241 ttaccaggtt caatagcctc tgcagcaaca ggcagtcctt tttctccatc acccgttggt 414301 gagtctccct atagcaaacg ctttaaacta gacgataaac caactccgtc tcagacggct 414361 cttgattcct tacttacaaa atccatttca agccctagat tacccctttc gacgttggct 414421 aacacagctg tcacggaatc ttttcgctca cctcagcagt ttcagcattc tccagatttt 414481 gtagttggtg gtagctcaag ttcaacaacg gaaaataact ctaagaaggt aaatgaagat 414541 tctccatcat cttcttcaaa actagctgaa cgacctcgtc ttccaaacaa cgactccact 414601 actagcatgc ctgaaagtcc caccgaggta gctggtgatg atgttgatag ggagaaaccg 414661 ccagagtcaa gtaagtcgga gcccaatgat aacagcccag aatcgaaaga tcctgagaaa 414721 aatggtaaaa acagtaatcc gcttggtacg gatgctgaca aaccagtacc aatttctaat 414781 attcataatt ctactgaggc tgcaaattca agtggtacag tgacaaagac agctccatca 414841 tttccgcaga gttcttctaa gtttgaaatt ataaataaaa aggatacgaa ggcggggcca 414901 aacgaggcaa tcaaatacaa gctgtccaga gaaaataaaa caatatggga cctatatgcg 414961 gagtggtata ttggtctgaa cggtaaatct tcaataaaaa aattgattga aaattatggc 415021 tggcgaaggt ggaaggttag cgaagattca catttttttc ctactagaag aattattatg 415081 gattatattg aaacggaatg tgatcgtggc ataaaactcg gcaggtttac taatcctcaa 415141 caaccgaggg aggatatacg gaagatttta gtaggggacc tagaaaagtt caggataaat 415201 aacggtctga ctctgaattc tctatcattg tactttagaa atttaacgaa aaataacaag 415261 gaaatttgta tttttgaaaa ctttaaaaat tggaacgtta gatcaatgac agaagaagag 415321 aaattaaagt attgcaaaag gcgacataat acaccatctt aagtttattg aggttgtccg 415381 cgacaatagt tccttcaaca aaataacgaa gcgacgataa cgagaaatgt cattaggtta 415441 ttactacctt tatagaaaat atatatactt atttaatatt tatatagatt tatgtgtgta 415501 catacctatg cggatgtatg cctatgtggg aattcctaaa tgtctttcca tcaacgacta 415561 aatatatatt ctcatgactg actatatggg ttacgaaaac ttaatttttt tgtcaaagac 415621 cctggcgaat tgagaaaacc cgctggatag atgggctatc cgaaattttg aaagatggaa 415681 aaaacattaa tctcattagc aaaagaggta agaccctggg tgaagaaaag tccgaggagg 415741 gaacacaaaa aagtctagga taatggcaca tgaaaagttt agtatacctg agaacttcac 415801 attagcgcag tctttgcaat tgctttactc tgttgtcaaa aatcaatata aaaacctagc 415861 agacctaata atcaatagca aaggtaataa ggacacagta acgtatggga aaatccacaa 415921 aaacttagac actttactgg tatacgtcaa tgaaggtcta cgaaaaattg aaaagactta 415981 taccttaaag aaagggttag gaaatcttgt agttgatcat cctgaattga ggagcatcat 416041 tgaggatttc caaattcttg gccaggatat aaggatcgca cgtcgtaaag cagaaacgct 416101 tatggccgaa ggaaacggta gtccctcttt gtcatcctcc tcttccgttt tgggccttgg 416161 gacaggaaat ggtttgcgtt ttccaaaact ttggagaatg ggttccaaaa gagataaatt 416221 gaaagaagct gacgaaaagg aggctaaaat caacaaacag gctgataata tcagacgtgc 416281 taggaaatta gaagaagaga aaaagttagg agcaaaactt cagtatgaga gggacttaga 416341 acttcaaagg gaaaaattga tcgagttaaa ggttaaagaa aaggtcgaat ttgaagtggc 416401 ccaaaagttg gaggaggaga gagttaagag agaggaagaa gaacgcaaac atagagaaca 416461 agcggagaaa aaacgtatat caaccctgaa acatgagagg aaaacaaatt acaaatcaag 416521 ggctagcctc gacaacttct cttccagtag caaatcttct ggaaagattg acaactccct 416581 aattaaaaga agatcacttg acgttgtacg gacttcaggc gaaagagtac gaacgccagt 416641 aagaaaatca atggaggcag cagaaatagg tatggctgcg cagttagcct ggtctcagta 416701 tcaaaacggg gcaaatcatt caaaagtgag taacaacgga tcgcattcaa atgaacttca 416761 gatacgttat aagccaacac cacctttgaa aaaaaggtat gactacaaaa agccaacagt 416821 taatcgaccg attataaaat cacctactct taacaggcaa aacagcaagt cttcacggaa 416881 tatacccaca aatagcaagc tgaaggctag taaatccaat actaacaaag tttctcgtag 416941 gaatgagcaa aatttggagc ctagttcacc agtactcgtt tcagcgacag cggtacctgc 417001 tgaatccaaa cccatgcgtt ctaaaagtgg tacacccgat aaggaaagct ctgctagttc 417061 atccctcgat tccagaaagg aggatatatt aaaatcagtg cagggagtag atcgaaacgc 417121 ttgtgaacag atacttaatg aaattcttgt tacggatgaa aaagtttatt gggaggatat 417181 cgcaggctta cggaatgcga agaattcttt gaaagaagca gtggtttacc catttctgcg 417241 gcctgactta ttcaaagggc taagagaacc tgttagaggt atgcttttgt tcggcccacc 417301 aggtacaggt aagacaatga ttgctaaggc ggttgcgaca gagtccaatt ccacattttt 417361 tagtgtaagt gcatcttctt tgctatcgaa atacctcggt gaatctgaga agctggttag 417421 agcattgttt tacatggcca aaaaattgtc accctcaatt attttcatag atgagattga 417481 ctctatgtta acagctcgct ctgataatga aaatgagtcc tcgaggagaa ttaaaacaga 417541 acttcttatt cagtggtcct ccctatctag tgctactgca caatcggaag accgaaataa 417601 tacgcttgac agcagagtac ttgtcttagg agcaacgaat ttgccatggg cgattgatga 417661 tgcagcaaga agacgatttt cacggaaact atacattcct ttaccagatt atgaaactag 417721 actatatcat ttgaagagat taatggccaa gcagaaaaat agcctgcaag atttagacta 417781 tgaattaata acagaaatga ccgaggggtt ttctggttct gatcttacgt cattagccaa 417841 agaagcggca atggaaccta ttagagattt aggagataag ttgatgtttg cggattttga 417901 taaaatcaga ggaattgaaa taaaagattt tcagaatgct ctgttgacaa taaaaaagag 417961 cgtgtcgtca gaatctctac aaaaatatga ggagtggtct agtaaattcg gtagtaatgg 418021 ttcctgaacg agagggagcg tcttaatggc aaagaaaggt atgagaagga attttcccct 418081 ttcaacttct tgcttctgat ctaattttat tacctatgta ctttctatgt attatcaaag 418141 aaaaactaac ttcggttccc ttatgatttg atatttttct ttcttattta caattagttt 418201 tctcagaacg atattcaata cagttctccg gatttttgct tactatattg gccccaaaaa 418261 aatgaaataa aaaaagaaaa caaaataata tacttgggtg aaataaaaaa aataaatcaa 418321 tagcacccag ttaacctaga ttcaaagttt cttcttcaat ctcaatttat atacacgttt 418381 gagttaatgg gaaagcaaag tccagctata aaacacttga ccgttagcgc cataccctcc 418441 aacaactaat tggaccttct ccttctgccc aaacagtata tgcaaggtac agcagttact 418501 acaagcacaa tatgtcttgg ataaaaaatg taacagaatc tccgacttca ctgattaaaa 418561 aagtttcatg tggtttgata attgctgctt ctctatatgc cattgcaccc agcctaagtg 418621 cgctagtctt tggggattct aagcagagta ttgggaagta cacgacagtg ggcttaatta 418681 atcgtgggaa tgattgcttc ataacatcat ctttgcaagg cctggctgga atacctcgat 418741 ttgtagaata tttgaaacgg ataagaacgg tccttctaga attagaaact aagctgtcaa 418801 ataatgcaaa aggcgacaat cctacagttg ataacactac aaggcatagt cgacttgaaa 418861 actcgtctaa ttcacttgcc cccttacacg aaagtcttac cagtttaatt ttggatttga 418921 tatctgtaaa agatcgtaag acgtcaattt ctccgaaaat agtgataaac acattagagt 418981 ccatctttaa atcaaagatc tcatccaaac aaaatgatgc acatgaattt acattaatat 419041 tactacaaac attacaggaa gaacgatcaa aattgatcga ttacagtaaa cagatatgta 419101 atttgaatat accaaagttt ccatttgagg gcgagacttc caagtttcta gtatgcctta 419161 aatgcaaggg tctatcagaa ccatcataca aacagacttt catccgcgaa ctgtccgtac 419221 cacaacaaac atcagagaat ctatccaata ttctagcaca cgatgaaaca gaaatcatag 419281 acgactattc atgcctgatc tgccaaataa gagcaatctt aaaccatgaa gaatatagaa 419341 atttcaagga ctgtaccccg gatgaaattt taatgttgga cagattgaaa aattatgcca 419401 ctaaagcccc aattaacgaa aatttaccat tcgaagtaga acagtacgtc aagcgttact 419461 caaagggcaa tttgcaggta tctaatataa agggaaaggt catcaaaaaa gatgtagtag 419521 tacaactgcc agacatatta attgttcact tatcgagatc cacattcaat ggtattacat 419581 attctagaaa tccctgcaat gtcaaatttg gagaaagaat aacactttct gaatatacat 419641 tggctgagag tgggacaata acagaaaaca ggcaagtcaa atataatttg aaaagtgttg 419701 tgaaacacac cggttctcat tcgagtggac actatatgtg ttacagacgc aagactgaaa 419761 ttcgtttcgg gaaggaggat gaatcttcct tcagaagagc accagttgtc aacaatgaag 419821 ttaacaagaa tcgcgagcaa aacgttgcac ataatgatta caaaaaaagc agatataaaa 419881 aagtcaaaaa cgccctgcgg tatccttatt ggcaaatatc tgataccgcc ataaaggaat 419941 ctaccgcttc aactgtcttg aatgaacaga aatatgctta tatgctatac tacgaacgtg 420001 taaataaata accgccctgt acataggtat attataataa tagtaagtta cgcatccata 420061 tccacatcag tatccactgc catcatttca acatcggtat cagcctctcc atcataagtg 420121 tatttcgaag tcatttgatt atggaaccac ttccaccagc ttagataagc aatttcctta 420181 taatctaccc attttattat ttgtagcctt ttttctctca aacgttccca tattttgtca 420241 taaaacaagt cattgtcgcc gcgtttactt gtggaacact tgatgatctc tttcaggacc 420301 ttatcatcaa tagcgtctgt gaatactata ttgttatgaa taagattgtt atcatctgca 420361 tgtccgttct tgggcccttt atcatttaag gataaattct ctaaatctat aattagtctt 420421 tttcttttat aattatcaat tcctattggg tctggagaat gatttctttt cctaatgtgg 420481 ttgggattgc cattacttct tgcaaaccgg gaactcatgg aatgaaaaag tcatttaaac 420541 gtgccactag ttttactatc tgctaatcgt tctagacgtg taatataaat catatccgag 420601 cgccgttgtt gaataattta atgccttcgt attacataca ttttgaaatt tgctttcgta 420661 aaagagcggt tcccggataa aaaagtgtgc aaataaccga gccttatttg atttccagta 420721 aagacccaac caaacgcatc attgaagcaa aaatagatta aaacttactg ttgttcgtct 420781 attgaatttt gttcggattg gtgtggtgtt taatatcttg ggcagaaaga gaattggctt 420841 tatagacact cataaaatca tcattcccct tagagcaaaa ggtattttta gaagccaaga 420901 agaagagcag ataaaaaaga agtacgccct ctaacaataa aagtcaaatg gctagacaat 420961 tattcactcc tccgataacc aatccaaggt ttgaccctaa tcaatccatc agggaatcat 421021 acaagaacac aactggcggc atgcaatttc aacaaaatct acatgaggat caaaatgaca 421081 atgagagaag tagctgtgat ggtgatgaaa actctacaac aggagaaagg ctagaaaaca 421141 ataagtctcc tatattgaca aaacaagaaa ttgacgaagc gttgaacact gtcaccaatt 421201 tacctccaga attatcaaaa ttaattgaca tttttattga tgacctaaag cagccaaagt 421261 acgtacggcc actatcagta ctgcaattgt ctagtctttt ccaaagcttt tacataaaat 421321 ttgataaagc atcattccag cacgtcagtt cagcgaataa taatggctat tatttttctg 421381 gcgggggctc tagttcattc ttggctgcca aagaaacgtt aagtagtggt cttagcggaa 421441 tttttggcag aagtaggagt agtagtggaa attcacttat gaggccaaga agatcttcat 421501 cgcttttcag taatgagtca atatcaaatt caactaatgc cacacaaatg ttgtcacctg 421561 aagagataaa aaagcaattg aaaatcaacg aattaaacaa catgaaaatc gaaaaatata 421621 tggaactttg tgaaagagat gtttttaaga aaattcttat agtaggcaca tccgtatctt 421681 caccgaataa aatgaaaacc ttcaaaccac accaattaca aactttcaag gttggaaatc 421741 tatttagaaa cagtgttgaa ttcacagaat acaataagtt gttgaatgaa aaaatcctct 421801 gtttgtccaa actctcaaca atgaataaaa tcaatttgat aaagtttctg agtcttaata 421861 atggcattga tccggaacca aagtttgaag agatcaaaga tattttatat gagtttactt 421921 atcattcgat ttcaccatgt gaaaagataa aggccctact gaaactacat gaaatcatga 421981 catattccca agaaatgtct aatgatgatt atctttcgtt gctaatctac tacattatta 422041 cgattgttcc acgggatatt ttcttgaatg ccgaattcat caggctgttc agatataaga 422101 aaaagctggt cgaaacagaa tcctttgcat taaccaatct agaagctgca ttagtttttg 422161 ttgaaggctt aaccaaaaat gatttttcaa atgagctaca agataaattg actgtaaatg 422221 aaagtaaaat tttagaaaat tcaatcagca gtagagtctc attgccatca aaaactgcta 422281 taatgcataa aaacaacggt aataacggca gtaacctagg tgacatcgtg actcctacta 422341 tccaaaggcc agatgttaca agatcgaatt cgtatgatgg cttcaggacc gtttttgatt 422401 catcattaaa aaatatcatc ggaaaaatta ggtcatatac tccaccacat cctaacaata 422461 ctagcaataa taaccttcac agtagcaaca acttaaacat accacgaagt tcgtctcaat 422521 tatccatgga attgagcaat agagatacaa cagagatgtc tagggatggc tcacgatcaa 422581 cttcatcatc ttcacgatct tcagcatctt tagagcacgg aaatcgcgaa tttaccggcg 422641 atttgacagt aaccgctagc attaacggtg ctgataaaaa ggagtttcag aaatcgtgga 422701 aaaaatataa aggctataaa tttgaagatt tgactatttg cgaactaaga gatctttttg 422761 agatatatca aaagatgatg caatgaaacg tatatatgaa atcgtatgta tagatgcgaa 422821 agaggaggag agaaggcttt atttctgact atcttcctcc actaatttga ttgatcaatt 422881 tatttcacaa ttcggataag tggtctatta tatataacaa ttcgtcatgt aaattggtgg 422941 cggtgtcgga atgcgaagcc aaatcaggta aatacttatt ttcattatca ttttttatca 423001 tattcactaa ttgattaata aaatttttgg tgtaggccaa tgaattggtg tcgaattcca 423061 gtatttgaat cagctttagt tttatatctt tatcacttgt cctcaacagg agaattctta 423121 gaatttcatt gtgttgctca gtttgacctt tcgttttagt gaagttaagg gcgtggacga 423181 tgggaaaaga taacttcccc tctgtaatgt cctcagcaaa gcctttttcg ctggacattt 423241 ggaaatcttt caaattcaag taatcatctc taatctgata aataataccc agaagattta 423301 tgaaaggaac caacgaatgg ccgtggtgtg aggaaggaga cagcgcttcc atgagtctca 423361 acgttaatct gaaaaggccg cctgttttat tcataaccat attcaaatac atctcctgag 423421 taggtatgat ttcaggcaga aagtctctcc agtatatatc caagccttgt cccctatgta 423481 gattgatcaa ttcttcgttg aaaatcgtaa tcaaattatg atacaaaggc tcttttgtgg 423541 ttagctgcga tacaagttgc atggctctga aatacatata atttgcggtg tttatagtgg 423601 agggtacacc gaagattaag tgagaagtgg tctgtcccct tctcaaggga gcattatctt 423661 ctatatcgtc gattaaaagg ctggaattat gcaagagctc aacaatttgc gaaactatgg 423721 ccagctggtc tttgggcaaa ttcataactc tgttaatttg aactattaaa tttagtctaa 423781 agttcttgcc aggtttcaaa aggatgtgat tataaggttt tgaaatcaag ctttcatttt 423841 ggctggacca aacaggatca ttattgatca gctcatctat cttggcctcc attgattttc 423901 cagactcgta aacgctttgt tctctttcta ttagtagctt ctttgaaaat gagccttaca 423961 tggttttgta agcacatctg tcttgacttt ttttttgctt caaaaaaacg tcaaagaagg 424021 caaggcgaag caaagaaaaa tggtagtaag catacaatga tcagcataac atatgcaaaa 424081 acacgtaatt tctgctatgc tggaagcggt gaacgttgga taccactata ataatagaag 424141 tttacctttc agtatgaaaa tgcgggcttg tcctatatct atatgtaata ttatggagtg 424201 agtagagatg gcggctatac atcgttgtag agagttatat ctgtattgtt aattaaagat 424261 tggccaggcg aaggttggtt cctttttgct ttaaatctgc ttttatgggg ccataccaga 424321 gaattatttc tttctttcag tattggcttg tcaagctttt tgataatgct attaagtgtc 424381 agcgaattcg ccgtagtttg caacgctgtg ttgtttgtat ggcaattgtt attatatact 424441 tccaaattaa tcaaatctac caggttaata gaatgcaaat tcgctatctc atggatgatg 424501 tcattgtggt aggcagtgcc gctgtgactg gggtggctaa atggaggttt cctctcagct 424561 agcatttttt tcaatttgtc tgagtgcgct tgagaggagg cctttaattt ggaagtagtg 424621 actggtcttg tcttcgagtc actgtttaat tgctcgaatg aatataatag gtttacgatg 424681 ttttgtagga gttttagatc attgggcagc cttaacattt cgaaattttt caagccggcg 424741 agagtcggct tatgtatatc tttataaaat aatctttgtt gtcttttgat gagattggac 424801 aaatttttct gaacttccaa tacagagatc ttttcgggat catcatcagg tgaagatagg 424861 ctggcgctat tgtggaattt agggcgctgc agaggcttag gtattattat atttgaggtg 424921 cccagtgttg tggttgtggc tcgaatagct ggactaacca tgttttgtgc gactacttta 424981 cgcttcttag ggacaataat ggatggtacc gctgccgttg tggttgaagg aggatcggac 425041 gtctgatttc tccctgaata gtcaaccctt tttcttttcc tgagttgcat atgcatatta 425101 tattgtatgt gcttgtgtag gtagaagcgt cttttattta tctactgtct catcagctca 425161 tcgcatcatt aataccagta tcggttatag tacataatta acaaatgtat gtagcatttt 425221 ggcatgctga aaaaaaaaaa aaaaacttta tcaggcaagt ggctcgaaac cgtgtgaaag 425281 gatatcatca acggtcgttt ttacctgttc cgcggaatag cgttcccgtg ggaagaaaag 425341 cagcacgtga gcgtggaaaa tccgggcaac actttgtagt tccgggtagt tgacaaacca 425401 ggccacgtga cccgagctta gaagtggacg cagtagcggc tgtgcctgca aaaatgcatt 425461 catgcgagcg cgggccgctt cgcgcacggc cttatctggg gaatgtactg gcagggcaac 425521 cttggaccag agaacaaggt gtacaacacc aggctcgaag ttatacggga aatcgttggc 425581 acgcacagca tatagagtag aagaactaaa agccttcgcg gcagcatttt cgagctgcgg 425641 ttcgtctagc gaccagccta gtttttgcaa aacgtactgg ttcatgtcca ggccagcagt 425701 ccttttctta tgctcgtggt atttgtcagt catctggcga cttcgtttca aacgggcaag 425761 ctcccccgat tcaattatct ctttgatttg ttcccacttc cacccttggg cctcctcctg 425821 gtgatcgttg acgatatctt gttgcattgt aaacctaagc tgttataagt aaatcaagtg 425881 caatacaaat atatacagca tgctggcgtc cttagcctca cgcctactaa acaagagcat 425941 cttactctca ccatccattt atatacatat ataagtacgt aaaaatagat gtgtataagt 426001 cgttctatct ataacgcgcc ccgaagttgt ttagtataac aaaaacggaa aaaaaaagaa 426061 ggaaaatgga gattgccaaa agcgcgctag tttgacagaa agagtgaaat attagttcaa 426121 tatttcagct gtcacggtca tcactgctcc gacacttttt tgtgggatgc tttctgttca 426181 ccttggtttt ctatgggtat ataacagctg ataaagaatc gaagaagtga aaatgacgca 426241 cccagttata tcactaaagc caagctacaa ttctgtaata cggggctgcc ccggtttacc 426301 tgatacgtta ccacgaatcg aatgccagtt aagagtgcgc tcaaacaact ctttgccatt 426361 caaattggta aagatcgaaa ttgttttaaa gacaattgaa atatatttca acaaaaacct 426421 ttatagcagc aataacagct ctttcacccc atttaatcgt ccgtcggacc cctctaatgg 426481 ccattctgac accagtaacc agaacatcag cattcattat aagaaaaaca tcgtgttatc 426541 ccaccctacc catgatggcg acgatctcaa caatgatctt attggcatag acataccttt 426601 gacgattggg ctacctgacg acatcaaaga aacaaactat aatccgaaat tcggcaaaac 426661 gcagactttc ctggattgta ccgtgtttta tacagaggtc ggcggaggaa gctcaaataa 426721 gaaaagaaat tttctttacc cagtaaacgt cgaaaggtat acatacctac cttcaccgtc 426781 atatttcagg ccaataaaca gatcaaacat cacttctccc gatcaaaagt tcttaattag 426841 ttattccatt gagaatccct gtgtttctat gaataatgac acgttgaaac tctccatatc 426901 aatcaggctg aacccatttc cgaacaatgc cacaactccc tcttcgaatg actttgatgt 426961 gtccacgccg acacttttct ccacaaagaa aaagtttaag tccaagctca aattgaaatc 427021 aattacaaca cagatactag aatacttgga aattctgaag aaccaatcag aattctcatc 427081 cacgcaaaca acaaatattt tgcaaacctc tgtaagacag gttgatcaaa tcatctccat 427141 gaattcaatg atttttcaat tcaacctaaa aatattcact aaggacaaaa ttttacaaag 427201 ctttagatct tctgagtcga gttgtcccga aactaaagta ttaatcaaca aaatcgacga 427261 cattcctctg caatatcata gttcgataac tacgataggt caacatttta atgtttctca 427321 ctatctttca ataaggttca aattcaataa aagtctgaaa aacttcgaaa ttaatcaccc 427381 cctaatcata tcgttttggt cagtaagtca attgccgcta atcgagaacc taatattgca 427441 agaaagacaa actgctaaat ttgccaagaa gttttataaa aattttggtc gaatcaagaa 427501 cacgagcaac aacaataaca gctcgaactg tctagagtat ccctccttgc cgccaataat 427561 ttataatttt aacgacccag aaacaaataa tagatttaat atattatact cgcaaaagga 427621 ccctagtcgt acggatcctt ctaaattgag aagagtacct gtcatacaat gaggcagtga 427681 ttggcatggt tcatatatta aatcaacgca gatacgtaga tctataaagc ttttgaataa 427741 tgctaatgta ttatatattt atattcttct tgtcccgcac tctggtcttt tcaattttct 427801 acatgaagag aaaaaaagac tatagcgtcc ggcaaaaaaa aaaaagttat ggtttaacaa 427861 tacaacggcc ccatgggttt aaaataaggg cactttcata aagtcactta tcactcaaaa 427921 gcacccatgc aaaaacacaa tataaaatta aaccaaaacc aggatatttc ccaattattc 427981 cacgatgaag tacccttatt cgacaactct ataacttcaa aggataaaga agtcattgaa 428041 actttatctg aaatatattc tatagtaatc acactagacc acgtagagaa agcctaccta 428101 aaagactcca tagatgacac ccaatacact aatactgttg acaaattact aaagcagttc 428161 aaggtctacc tgaattctca gaataaagaa gagataaaca agcatttcca atccatagaa 428221 gcgttctgcg atacatacaa catcactgct tcgaacgcaa taacaagact ggagaggggc 428281 ataccaatta cagcagaaca tgcgatatcc actaccacat cggctccctc tggtgataat 428341 aaacaaagtt cttctagcga caaaaagttt aatgctaaat acgtcgctga ggccactggt 428401 aatttcatca ctgtaatgga tgctttgaaa ctaaactata atgcaaaaga tcaattacat 428461 cccttattgg ctgaactgtt aatcagcata aatcgcgtca ccagggatga ttttgagaat 428521 agatcaaaac tcattgactg gattgtcaga ataaataaac tctcaattgg tgacacttta 428581 actgaaacac aaattagaga acttctgttt gatctagaac tagcctataa aagtttttat 428641 gctttactgg attaagaaat aaacaaatag aaattatgat aacatatata agtacacaag 428701 cgtttctatt tcactttaga atattcttgt tttttattcg ttcttgaaat tttgacaaca 428761 ttgccaaagt ttcccgctct cttttatcca ttggttcttc cttgatgttt tcttgacttt 428821 ccgtttcttt agtggttgcc tcatcaacat tatcatgcaa ctccgtcttt tccctaatta 428881 gtgcctcttg tggctgatct aaggatgcgt ctagtttaat tccttcactg cgactatcat 428941 ctttgatcca tgctgggaga atcattctct ttcttggctt aagcttttga acatcaccat 429001 catcatcctc ttgctcatct tcataaacca tctttacttt tgctgatttc acaagtttct 429061 ttgccggctc ttgttctttt ttttcattat cttccagtct tctttttgat ccaaagatgt 429121 cctcaaagaa tggtatggta atctcaacat ccttcaaaac tgcaggatac atgaatcgtt 429181 tgacatcatt gtcacgggag gaagcttcaa tttcgccgcc caagatctct ctaaagatgt 429241 aaatagattt cccaacaatt ttgccaaata cattacaatc gttcagtacg tgcttagaat 429301 ccgccagcac agttataaac catgtgttcc ttcgtctatc ccatcccaag agtccatctc 429361 tattgaagcg tatacgagga tttttttcct cagcaactgt acggtactca ccagtactat 429421 ttgcattaaa cattagccac tgtgttggct ttaactcttt aaattctcca ttggtgaatg 429481 tgccatctga gagcatagat aagaacctct tacatgtctc agggcattct ttagcccata 429541 attcaatggc aatgttcccc tttgttgtat acagtataca tttagctgtt gtctgaggtt 429601 ctatattact ggacatagca ttcttacttt ggtttaaaac tcatcataca tgtttcctgt 429661 aatacgcttt gaataataaa ttattcaata aattattctc aggacatttt gaaccttttt 429721 ttctcttcag acgctttaca gcggaaaagg aaaaaaaaaa aattggaagt tctttcagta 429781 aagtgagata tattcagcaa acgaacataa cgtcaggatt aatcggaacg gtaatttcta 429841 gcatccactc aatttcgtga ttagcttttg gcgcataact gattttttgc tttagcacat 429901 cacagctaga ataaacttcc aaaaatcacc cgcttgcaat gctgtccatt ttaagaaatt 429961 cggtgagact aaattcaagg gctcttaggg ttgtgccatc tgccgccaac accttaacat 430021 cggttcaagc atccagaaga cttttaacaa gttattcaag ttttttacaa aaagaaacaa 430081 aagacgacaa gcctaaatcc attcttacag atgatatgct gttcaaggcc ggtgttgacg 430141 tcgatgagaa gggccaaggc aaaaacgagg aaacatcagg agaaggagga gaggacaaga 430201 atgaaccttc ttccaaaagt gaaaaatcta gaagaaaaag acaaacttct acagatatta 430261 aaagagaaaa gtatgctaac tggttttaca ttttttcgtt gtctgcgttg acaggtactg 430321 caatctacat ggcaagggat tgggagcctc aagagtctga agaattgaag aaagacatcg 430381 ataatggcta cactttatca cttatgtata aaagattcaa ggccaggttc aactcaatgt 430441 tcacctactt ccaagagcca cctttccctg atttactacc tccaccacca ccaccaccgt 430501 accaaaggcc attaactctt gttatcacat tggaagattt tttggttcat tctgagtggt 430561 ctcaaaagca tggttggaga acggccaaaa gacctggtgc tgactacttc ttgggttacc 430621 tatcgcagta ttacgaaatt gttttgtttt catccaacta tatgatgtac tctgacaaaa 430681 tcgctgaaaa attagatcca atccatgcat tcgtatctta taatttgttc aaggaacact 430741 gtgtttacaa agacggtgtg cacattaagg atctgtcaaa attgaataga gatttgagta 430801 aagtaatcat tattgacact gaccctaaca gttacaaatt gcaacctgaa aatgctattc 430861 caatggagcc atggaatggt gaagctgatg acaaattagt aagattgatt ccatttttgg 430921 agtaccttgc cactcaacaa accaaggatg ttagaccaat cttgaacagc tttgaagaca 430981 agaagaacct agcagaagaa tttgatcatc gtgtgaaaaa attgaaggat aaattttacg 431041 gagatcataa atctggtggc aactgggcaa tgacggcact aggtctcgga aattccctgg 431101 gcggcagcac caagttcccg ctcgatttga ttcatgaaga aggacaaaag aactatttaa 431161 tgttcatgaa gatgattgag gaagaaaagg aaaaaattag aatacagcag gagcaaatgg 431221 gcgggcaaac atttacgctg aaagactatg ttgaaggtaa cttgccttcg ccagaagaac 431281 aaatgaaaat acaattggag aagcagaagg aggtagacgc cttatttgaa gaggaaaaga 431341 aaaagaagaa gattgctgaa tccaaataat tttcatgtaa accctcttct catgtatcta 431401 cgtatctatg tgtgtatgta aatgtacctg tacactcccc acaccctcat tttgttactg 431461 tcatgtgaat aaaacttatg tatattgcta acttactacc actgcacctc ctaacatcac 431521 catactacgt acaaacacgc ctatttattt tttctatgtt aaattttaac gatgtagaca 431581 cacctaatga tctgatgcgc tttgcatatc tcatattcct tcactagcat aaaaatccaa 431641 aaaaaaagaa tatttaggcc gaatggaatt attcgtaacg tcatacgaaa aaagtttcaa 431701 ttcgtacaat gcctggcatg ttcattcgaa tataaggccg ccgccttcca gtcagggtag 431761 ccaaaagtat aatcccgggt ggaaactaaa ctaaaaaccg tactcacaac tttccgcgga 431821 cgctaacaga caaatagaca cactatcagg tcaggaactg ccgtcacata cgacactgcc 431881 cctcacgtaa gggcatgata gaattggatt atgtaaaagg tgaagatacc attgtagaag 431941 caaccagcac gtcgccgtgg ctgatgaggt ctcctcttgc ccgggccgca gaaaagaggg 432001 gcagtggcct gtttttcgac ataaatgagg ggcatggcca gcaccgagac gtcattgttg 432061 catatggcgt atccaagccg aaacggcgct cgcctcatcc ccacgggaat aaggcagccg 432121 acaaaagaaa aacgaccgaa aaggaaccag aaagaaaaaa gagggtgggc gcgccgcgga 432181 cgtgtaaaaa gatatgcatc cagcttctat atcgctttaa ctttaccgtt ttgggcatcg 432241 ggaacgtatg taacattgat ctcctcttgg gaacggtgag tgcaacgaat gcgatatagc 432301 accgaccatg tgggcaaatt cgtaataaat tcggggtgag ggggattcaa gacaagcaac 432361 cttgttagtc agctcaaaca gcgatttaac ggttgagtaa cacatcaaaa caccgttcga 432421 ggtcaagcct ggcgtgttta acaagttctt gatatcatat ataaatgtaa taagaagttt 432481 ggtaatattc aattcgaagt gttcagtctt ttacttctct tgttttatag aagaaaaaac 432541 atcaagaaac atctttaaca tacacaaaca catactatca gaatacaatg actaagctac 432601 actttgacac tgctgaacca gtcaagatca cacttccaaa tggtttgaca tacgagcaac 432661 caaccggtct attcattaac aacaagttta tgaaagctca agacggtaag acctatcccg 432721 tcgaagatcc ttccactgaa aacaccgttt gtgaggtctc ttctgccacc actgaagatg 432781 ttgaatatgc tatcgaatgt gccgaccgtg ctttccacga cactgaatgg gctacccaag 432841 acccaagaga aagaggccgt ctactaagta agttggctga cgaattggaa agccaaattg 432901 acttggtttc ttccattgaa gctttggaca atggtaaaac tttggcctta gcccgtgggg 432961 atgttaccat tgcaatcaac tgtctaagag atgctgctgc ctatgccgac aaagtcaacg 433021 gtagaacaat caacaccggt gacggctaca tgaacttcac caccttagag ccaatcggtg 433081 tctgtggtca aattattcca tggaactttc caataatgat gttggcttgg aagatcgccc 433141 cagcattggc catgggtaac gtctgtatct tgaaacccgc tgctgtcaca cctttaaatg 433201 ccctatactt tgcttcttta tgtaagaagg ttggtattcc agctggtgtc gtcaacatcg 433261 ttccaggtcc tggtagaact gttggtgctg ctttgaccaa cgacccaaga atcagaaagc 433321 tggcttttac cggttctaca gaagtcggta agagtgttgc tgtcgactct tctgaatcta 433381 acttgaagaa aatcactttg gaactaggtg gtaagtccgc ccatttggtc tttgacgatg 433441 ctaacattaa gaagacttta ccaaatctag taaacggtat tttcaagaac gctggtcaaa 433501 tttgttcctc tggttctaga atttacgttc aagaaggtat ttacgacgaa ctattggctg 433561 ctttcaaggc ttacttggaa accgaaatca aagttggtaa tccatttgac aaggctaact 433621 tccaaggtgc tatcactaac cgtcaacaat tcgacacaat tatgaactac atcgatatcg 433681 gtaagaaaga aggcgccaag atcttaactg gtggcgaaaa agttggtgac aagggttact 433741 tcatcagacc aaccgttttc tacgatgtta atgaagacat gagaattgtt aaggaagaaa 433801 tttttggacc agttgtcact gtcgcaaagt tcaagacttt agaagaaggt gtcgaaatgg 433861 ctaacagctc tgaattcggt ctaggttctg gtatcgaaac agaatctttg agcacaggtt 433921 tgaaggtggc caagatgttg aaggccggta ccgtctggat caacacatac aacgattttg 433981 actccagagt tccattcggt ggtgttaagc aatctggtta cggtagagaa atgggtgaag 434041 aagtctacca tgcatacact gaagtaaaag ctgtcagaat taagttgtaa tgtaccaacc 434101 tgcatttctt tccgtcatat acacaaaata ctttcatata aacttacttg gtcttacgtc 434161 ataaataaat atgtatacat ataaattaaa aaatttggtt ttatattttt acaaaaagaa 434221 tcgtttactt catttctccc ttttaagcga tacaatccat gaaaaaagag aaaaagagag 434281 aacaggcttg tgccttcttt aaaacatccc acacaaaatc atattgaatt gaattttaca 434341 tcttaagcta gtgtacaaca actgctatat ccaaagaaaa ctaacgtgga ccgcttttag 434401 agttgagaaa aaggtttgaa aaaaatagca atacaaagac ttgtttcata tataaaatac 434461 agggagcaca ttgagctaat ataacataaa cactgcgaac caattccaat caaaaggtac 434521 acatgagagc attcccccga gtactgccat ttcgccatca gagatcatat aataacatcc 434581 ttcttcgaac agtaaggctt tttggttcat cactttcttc ttttgatttc tctaggcaaa 434641 tgcctaaggt ggaccctgac aataccgctg caatgctact acagaaaaac ttgatccaaa 434701 gaaacaacat gctctatggg tatggatcag ggacaatacg atgtactttg ctagactcaa 434761 ctggacgagc caaatcacca ttagtagaga taaaacgtga ggatctagta tcaaaacatg 434821 gcttgttgcc cagagatcta cgtaaaattg aaaaatcaag gaagaatgac ttagtcccta 434881 gtttgctcgt gcgagaaaat tccatactaa tcagtttact tactgtgaaa gccctaatta 434941 agcctgatat ggttattatc ttcgattcag ccggcagtgg aataacttta aactcagaag 435001 ctcacaagga ttttattaac gatatgaaat tgagactaaa aaatcaagaa acaagcgagc 435061 taaatagcga tccacttcct tatgaattca gagctttaga aacgatcttc atttcggcat 435121 tatctaacct taccagtgaa atgaaggtgt tgctaaccat atgcaagggg gtgcttcaag 435181 atctagaatt tagtataaca agagataaat taaggttctt actgggtcaa aacaaaaaat 435241 tgagcagctt caataaaaag gctgttctag ttaaagatat gctggatgac ttgctagagc 435301 aagacgatat gctttgtgat atgtacttaa ccgacaaaaa ggctggaaaa attagagttc 435361 aagatgatca tactgaaatt gaaatgcttc tggaaacata tcataactat gtcgatgaaa 435421 tagttcagaa aagcgaaagc gccatatctg acgtgaaaac cacagaagaa atcatcaata 435481 taatcctaga ttctaacaga aacgaattaa tgctgttagg gataagatac gccataggaa 435541 tgctttcgtt gggaggcgct ctattcctgg gttctatcta tggtatgaat ctggaaagtt 435601 tcatagaaga aagtaattat gcgtatttaa ctgtcaccat tttggggtta atatctactg 435661 tttggctcta tgcgaaggga atcagacatt tgcataaatt acaacgtatg acattattga 435721 gtaaaataaa aacagattcc gttcacgaac tgttgaagaa atagttatca cgaagagtca 435781 atcaatcttt ttaatacgca ttcaaatgaa taagaacaac tttcactttt ttaagtatat 435841 aaaaagccgt acaggcgaac gtatataatt aaaattcttt ggaaaaaaag aaagctcgca 435901 ctcaggatcg aactaaggac caacagattt gcaatctgct gcgctaccac tgcgccatac 435961 gagcttttgt tgtatagttt taaggcaata gaataataac acttatccac gcaacagtaa 436021 tgtggttaaa taataacttc ctgtcaggac ttgtggttga ttggtgaaaa tcaaatatca 436081 tgctgactac tagaaatatt agcagtatat tatcatatac ggtgtaagaa gatgagataa 436141 ggattgagaa acagtcatca agtttaatga aagtgaaatg aaaggattga ttatataata 436201 ggataatgaa tcacaaagta taaaaagaag gaagaaaaaa tgatatcatt gagaaattga 436261 tgaattttga gataattgtt gagatttaat tgttgataaa ggcaataata ttaggtatat 436321 agaatatact agaagttctc ctcgaggata tagaaatttt caaaggggaa tcgatttttc 436381 tacaaataat attactatta ttcctccttc cgttttatat gtttcattat cctgctatat 436441 tatcaatcgt tgcattaatc gttgaatttc aacttactcg aacttcgatg acagtttctc 436501 atcccttatg ttatcttctt acactgtatg tgataatata ctggtagtat gactactagt 436561 tgatagacga tagttgaatt tattccataa attatttatg taaaactgcc gacccctttt 436621 gtcgatttct atattctcga agagaacttc taacattttc tgtatacctg atattatagt 436681 ctttaacaac aacggaatcc tcacagttat ctacgattca tctatttctc atcagtaaca 436741 aagatatttc agtagttatt ttatataatt catgcgtttc acacatagag atggtttctt 436801 aagtttagaa tgacgtattt agctataata aaatgtttca ttgtgggata aaaacttgtg 436861 ggccatgaca tgagcaaatt tattatcaat gttgataatt agaggtaaaa aattagtatt 436921 aatgaagaag tgagtactga tcttcttata ctaaataaga gaggtatata aaacacacgc 436981 cgattggtca tattaatcat gaccaatata atagtggttc cggtagttac tatacattga 437041 tgtgacgact catattcctc atatatgtac ctaccatatc atgttcaact aataggtctt 437101 taacacagct tcagtattgt ctgagcttct cgtttaacat tccttctgca ataggcgcaa 437161 tcacacttaa acgtatacga gttgtacatt aatatacgat gtaagcatta gattgttacc 437221 atagcaactc atgtcactat taattactct cgttccaaca tgctccctta aagatatatt 437281 attgtacttc aacagatatt cattgtgtgt ttagaacttc attaattaat tatcaatagt 437341 ctgttgaggc caaaatatcc tgtgatgtta ttttattttt taatacttgt ataaatcttt 437401 taaaatcaga tgctgatact ggttttgtta gtaaatcagc aatattacct ttgccggtaa 437461 tttttaacag ttttatactc ttctctttaa ttttttcttt tattatttca gtttttatcc 437521 aagtgaattt ctcttttggt tgttgatagc tgcgatttaa tccttgaatg gctggctttg 437581 agtcagtgat catgacaatg tcattattgt ctccttctcc tagctccttt aatgttacct 437641 tcaacgtttc tgagtctgca tagccttcat aaatggcatg aagctctgct tctgttgatg 437701 atacacatct gtttgtgctc ttgttagaat aaacattaaa aatattcata ccgtaccata 437761 atataactcc aatccttgat tgagcatcat attctgatcc aactgatgca tcagttatag 437821 caataacctt cttgtcttta ttacagtctc ggtcatagtg tattccaata tctttatacc 437881 gaaccaagta ctggattatt ttgtaaatca tataaaagac tctttcatgt gggtaattta 437941 ctagtctagc cactttctta acagcaaaat taatgtcgta tctgcatttg tgtctgacat 438001 agtttagttc acctagtaat tgttgtagct ttagaacacc ttgtctaaac tcttcttctg 438061 acatttgcag tacgtctttc ttaggatcta ttttataagt tgacatatgc ggaattgaac 438121 tttttctaat ctttttcaat tcctcgttgt attttttatc cattctattt atgaatgatt 438181 ttaatgttaa atcgatagta ccaagtcttt tgttgtatac tagatccatt cctaatatat 438241 ctgtatcgag tacatcatct attaatgttc ctgtaatttt cagttcaaaa ttacttttca 438301 atttgtttat gaattcatcc aatctctgtt cattgcttgc cgcaattacg cagtcatcaa 438361 catagactgc aatcattaga tttttatcct cggtttggta taatcccgga gtataagagt 438421 tatctttcag tccaattcca ttcaagtatt gtcttagatg atcattccat tctttaggac 438481 tctgttttag accatataac gccttattta gcttgactac acatctccta tcatgcggat 438541 gtgggatgta tatttcttct tccaatttag catataggaa tgcatgattg atatccaggg 438601 tcttcataaa catatttctg ttgtttgcaa tcattaagaa tatcttaata tgattgtgat 438661 ttaaagattc tgtagttatt acactgtaag tgtctggtga ctgagtatca cctctgcaga 438721 ctatcctagc cttataaatc ccatttcttt tctttgtgaa tatcgtgttg gtgggtacta 438781 ttaaattatc agggatttct gatctactgt acttcacatc gacatcaaat accttcatat 438841 cttttaaatt ctgtaattct ttatgatatg cctgtttgta ttcatgtttt tctttgaggt 438901 caggattttt tgaaatagct tcattataat atatggctct aattttttgt gctgaaactg 438961 tttccatatt atctggaatt aatttcactc gattcctttt tgaacgcttc ttatctcttt 439021 ctaattcata gcttgttaga ctattgtttt tatcgtgtct tttccgtttt cttttcatgt 439081 tcaaagaact gaattctttg tttaagaagg cacttttatt aactgtttgt actggtgatc 439141 cagatgcttc aatattttgt tccaaccttg gtgacacatt tgttccattg tcagttggta 439201 catttttatc ggtgactttt aattctttta agttattacc atcctgacag tttgattcca 439261 tatcagtttg atcactcata tccacaatgt cctcaatcgg gggcggatga tgattttcct 439321 tctcaaactt ttcaactttg tttgtggaat aatcattact atggtgattg ttaatgcttt 439381 ctaaagtttt tattggtaaa ctcgtatcgc ctgtttttaa agaaatctca ttgtctgtat 439441 ttcggaattt tacattttgt tccaatgctc ccttctttag gaaacgaagt ttcatgattt 439501 gttttattga actgctcctg aattagttcg ggttttgcgt tgtgcattga ctcatctttg 439561 ttagtaatag attcatcggt gatatctaca catctactga gtccagtgtt taagatactc 439621 ccaatatttt tactacgaat tctgtcggag attctgtttt cgtcattgat tttaatagta 439681 tttttacttc ctaccagttt ctcttgtata atcgatggaa ttctgtggac tttttcatca 439741 tacttatctt catcaatatg acttgtattt attaatcctt tcttatcgat ttcactgatg 439801 gatatttcag tcgatgcaag ttctgaatta aaatccttgt ttgacaaaat tttgttttta 439861 tcagttgaga ttgaagtatt tgtcgttgaa agttcagatt caacgtcata atctccagat 439921 tcctcaacat cagaaaatac gtaatccaag tccccttcta ggttattact aggagatggg 439981 tattttgcgt ttgagtctat ttgagataac tcttcctctg tgaacaaatc ttccaggcga 440041 gtaattggtt tattatcatc ttcgtagttt tccaaagctt cacataagtt tgtgaccgtt 440101 tcgatttgat cttcttcatt atcattatgt gaactgaatt gatgactctt gtaaatattc 440161 tgagtatttc ttactctacc gtccatcgta tagttgggaa ttgtataatt atcagatgtg 440221 acaattttat ttttggatgg tataaagaat ttgtatccat aactatttgg atctttgcat 440281 agaattatag aaggaagtcc agatggtttc aattttttgt gattatgatt ccaaattatt 440341 cctttttcgc caaatggtaa gaatgacatt aatctcactg taacaggttg acgtgagatt 440401 gccttcaatg gtagtttacc tgtacttttg tgttccaggc aatttcttat attggtagca 440461 gaagttactg cgtattccca aaattttact cttaagttac tttgtcttag gagtgttgtt 440521 gcatcagtta ctattgttct gatgtatctt tctgctcttc cattagcagc atgatcttgt 440581 gtagaagtaa gtatgtgatg tattcctttt gaaataaaat attcttctat ctgatcattt 440641 gtgaattcag tacctctgtc tgaattaatt tctctgactt tcctgtcaaa ttgtgtttcc 440701 acgtactgaa tattctttct gatttgagct aaaatagttt cagcattctt attgaagtgt 440761 gtggaggtca tgcaatatct cgtgttgtta tccaccataa taagcatgta ccttttagtg 440821 tccgcgtttg aacttgatac agggccaaat atatccatgc accatgatga tcctggttca 440881 tgatcagtac tatgattatt catagacccg gtataatgat ttcttttcgt ggctttagag 440941 attttacagg tttgacacca aaattcattt ggttctttga ttaagtcaag ggattcttca 441001 taatgattat gttttatgga attttcaatt tgttgaattc ctgtatggcc cattctttta 441061 tgagcatctt ccaaggtaat agacctttta tttagtttaa atccaggaga agaagtaggt 441121 tttattgcat ttatttttga atcatcggaa ggacgttcaa ttaactcgtt catttttacg 441181 tgaatgacac cattaactat cttggtttta atttttatga ttttgtttcc caatctggta 441241 tattttcgac ttaaaaccat tttggttttc ttggctaagt cataacagct gattatagtg 441301 gattcttctt ccggtacata gtaagtcaat aaacacttat tgtcagtatt gttgtgacca 441361 ttcttgattt ttatatagcc atacccttta acagacactg aactgttttt cccaatacca 441421 aaaaatcgtg tactgcgatt actgtcttcg taattatgca gtaaggtttt gtcattggta 441481 atgtttacgc cggaaccggt atcaataatt accagttttt tgctgttgta cactttgttt 441541 gacttttttt gtgtcttgtt ccaagacttt tgttcttttg cactggactt aagttgttgt 441601 tgtctctgtg caccttgtag ataataggtt tttgagaaat tggtcgagtc aggcctaagt 441661 tccctatttg gtttcttttt gcagttaatt gagcaatgga aaacagattt gcaatacatg 441721 cagctatttt ctatttgatc gtctgcaatt gggctcaaat caattactgt ttcaataaca 441781 gtattgatta gaaattcttc gtgattaatt cctacgttat gtggaatgtt gtacaaacgt 441841 tgtttcacag aatttcttaa ggattcatgt aaggttccca tgatagcttc ttgtaggtaa 441901 tcctttagat taggacaatc ttggcagcat ttagaaaaaa tccatttttc cattagtacc 441961 aacttttgaa gtttattcat taacaatgcg gaatttctac atgttgtatc aaccaaaacc 442021 ttttcccagg ctctaattct gacatctcta ccatgtaaac ttctatattt gttttttaaa 442081 ccatcgatta tcctaaaaat gtcagttgta tttgtgttca tgatatctaa actttcaccg 442141 agtccttctt tgattatctt gcacaagatt tcattttcac gaggatcgat ttctatgata 442201 tcattttcaa agacatcatc aaattgatat ttcttgatga attttttaaa attgtttaag 442261 agaataggaa tgttctcgac attattagtc ctataatcaa aaacacaatc cttagggtag 442321 aatcttttgt tggttgaagt taacgtatcg aataaatagt aagtccctgt agcatctata 442381 tgttcatgta atatattatt gttctcgttt gtttccaata attgtatctt ttcaactaga 442441 tccacaatcc tattctcaac cttgtcaatg gtttctccga gttttaataa tttttcagct 442501 agcatctgaa tatcatcagt ctcagaaagt ttttcctctt ctgcctttaa accatttagt 442561 atggttttaa acctatttaa gtttctttga tattgtttca cctgttcatc tttaatagaa 442621 acttttctta atgatgatgg cgtctgtctg acagtatcat ttgttttgac tttcgattga 442681 atccgcgcag aaatgttgtc gtcaataaca tttcttgttt catccctcac tggggtcgcc 442741 atgttgataa ttagaggtaa aaaattagta ttaatgaaga agtgagtact gatcttctta 442801 tactaaataa gagaggtata taaaacacac gccgattggt catattaatc atgaccaata 442861 taatagtggt tccggtagtt actatacatt gatgtgacga ctcatattcc tcatatatgt 442921 acctaccata tcatgttcaa ctaataggtc tttaacacag cttcagtatt gtctgagctt 442981 ctcgtttaac attccttctg caataggcgc aatcacactt aaacgtatac gagttgtaca 443041 ttaatatacg atgtaagcat tagattgtta ccatagcaac tcatgtcact attaattact 443101 ctcgttccaa caatcaaaga atattaaatg aacttcaaat attaagtaat tctccttgtt 443161 ctgcttctac ggctctaatc catattagca tacccgatta atataattgc ctgcgatcga 443221 atacccaatg tactggattt tgttggaaca agtgatttat cacagttcac actgtcgtga 443281 agtaatttga cggtatatat catatataaa caatattcaa tggtgaaatc agcagtttgc 443341 gttgaattaa gaacatatac tacttgaaca taaactgggg ttcatgtaaa tggaaaatat 443401 gagccatcgc attgagcata tggcagtcat aagcagtttt gattctgctt aagattcaat 443461 taaaagtaat tgaaagagta aaatgtttta tagttcagtt agtaacttcg agcaagctag 443521 tgcttgccat ttaggccatt gaataattca gtacgagtat atgcttatta ttatggataa 443581 ttgatgcact agaacacaag gagaacgagt attttaacaa attgagctat tacaaaagga 443641 atacttagat acggcattat ctgacttaag gcttcttcat tagtgattga ttaaaagaaa 443701 aaatagaatg caaaagctaa aggaattaag cgaaactagg ttccagtaac acttaattta 443761 gtagccttat caatattaag aaaggatggt aacctctaat atatcactgc catgtaatga 443821 acttctatat tttagggatt taggagggtt ctgatctgaa tcacttatgt gttttatatt 443881 ttctacatac agcgcgactg ctgttttcta tccataatta ttttaagcat gcgctatcgt 443941 ttctacctaa tgacaaattg tggtaacagc cagatttatc tcaatataca ttagtagtca 444001 atatctcaaa cgacatcgaa tgccgcacat agccatttat tataacagat gagaaccaca 444061 tcacttttta ttacaaggtg tccattatga cgactgtaga agtatgcaaa tcataagtta 444121 gcccaaagaa gacatttaga ttttcttacg acaatactaa ttaaggtacc acgaacaaag 444181 agagaacagt aggtatgttg tattgctacg ccaacttttc ttgtgatcaa aaagttcaat 444241 gcattcattc ttctttataa tatagtacaa actgttaatt tactacatac ggaatcatga 444301 gattctaaat ttagtataca gagcttaatt tattcaataa agcataacta gtgccgtaaa 444361 gagtctaaac cggtatttgg cactgatctg agcttattgg aaaaacgtta cccgaccaaa 444421 ataaatcact tctaggaagt aaaggtataa agtattgatg acaaatgcgt tctagtccca 444481 aagggacaag aagttgtatt actcttttca catatatcaa ggccacaaag gtatctgttt 444541 actttttgac tttagcaaaa atttgaggaa atcagacaat gtttctccca aaattcaatc 444601 ccataaggtc attttccccc atcctccggg ctaagactct tcttcgttac caaaatcgga 444661 tgtatttgag cacagagata agaaaagcta ttgaagatgc catcgaatcg gctccagtgg 444721 ttcttttcat gaaaggtact cctgaatttc ccaagtgtgg attttcaaga gcaaccattg 444781 gattattagg aaatcaaggc gttgacccgg ccaaatttgc ggcttataat gttttagaag 444841 acccagagct acgtgaaggt atcaaagagt tttcagaatg gccaactatt ccacagttat 444901 atgtaaacaa agaattcatt ggtggatgtg atgttattac aagtatggca cgctctggtg 444961 aattggccga tttgctagaa gaggcacagg cattggtacc tgaagaagaa gaagaaacca 445021 aagatcgttg attttgttac cactggaagc aaaataggaa ctggtggccg aacactttaa 445081 tactcgtgtg cataataggc ctttacgatc catatttata tatgcatgta catttgctat 445141 ttttttaaag atttgtaatg tattctcatg cctttagact tgtaaataac agattctcta 445201 cttacaaacc cctctctttg ctttgccaaa tgaattgacg ttataaaaca aagaagtgag 445261 aattatgaat atatttaata ttccccgcat agacttgaat caaaaaacgt tagttttaga 445321 atgacagaag ccatatcttc gttctgattc aacgtgcgaa agacgcgaca gacatttgtt 445381 ggggttgtct ttgttactct cttgattttc gatagattcc gtactgttac cagtttgctt 445441 ttcccccatt ttttttaacg taaaaggatt ggaagataat aggcgagctc aattttattg 445501 ccctgcgaag ctttcaaata tgttagtcaa aggatcaaac ttccttttga aggtgatagg 445561 gatataatga acacacaatt gtgcctttaa gccattactc acgagtggga tagaaatgaa 445621 attcttttct tttaaatggt attaataatt aatatattaa ataattatat tgattctata 445681 cataaaacat tagtgtgaaa ttttcggaaa ataataatag aaagtaaaat caaatgtaaa 445741 attaaaaaaa tgatgttaaa ggacgccaaa atttgtgaaa aaaaattgaa aataaaaatt 445801 gtgtgttaaa ccacgaaata caaatatatt tgcttgcttg tttatttctt cgtgatttta 445861 ttttcgtcac ctggaactgt ttggaaaatg ttggtatctt tttcatgtct ttcctttctt 445921 ggcccattaa accatttctt gaaattcaaa acagacttca aagaccacac cttaactctt 445981 acaacatagt aacaaatcaa catagcggca atattgaagc aaatataagc ccacatgaaa 446041 ccaaagtttc tccatctgtg atcccatttg acattgtatt tagccacaac ttgatcttga 446101 acagtgtatg ggcaatattg acagttttcg gtggcagttg gatttaccaa ataaccggta 446161 ttattgtcca tataggtaga taaaaactca ccacaagttt ttccgcttgg tgggtccatg 446221 atgttgtatt catgaggatt acaaacgacc tttttattgt gaactaatgg tgtaaccaaa 446281 gcttgaacca cgtaggtaaa tggtgataca ttatacatca atcttctcca gaaggcaggc 446341 attttctctc ttggttgtaa aataccacag aacagtaaca tagcagcaaa caaattggaa 446401 ttaatcatag aagctgaggg aacatcagga gacatgtaca ggatccatag accatatgtg 446461 acaaaatata atgggaaaat taaaacatag aagaagaaga agaaacctgc atgagatgca 446521 cgtccactga attgagctgg ccagtagtag caaatgaaac acataaactg acaaagtgtg 446581 gaccaaaagt tttcaacagc agcatgacat aataacaaga cactccaatg gaaagtgtta 446641 gaagcggctt ctctaacctc atataattcc ctactatcat aagcgaagac gtgcagttga 446701 ttgatcatag ccagagcaat caataatagc atgaaaatag acgaaaaggc ctcaatggca 446761 ccaccaacag agtgatttac accaacatat gataaaccga cgaacaaagc acatgcgaca 446821 cattcaaaga atttggccct gatatagaca ggcgatctcc aaaattgaag agctgttcta 446881 cgtaaaacac atttgatttg agtcatgtaa ctggcagcaa atcttgtagc taactcagga 446941 tcatcattaa ctgctctacc aggtaaagta cgatgtaatt cttcaacttc agcccttgca 447001 gcggcacatt ctggggaagc aagccataag tcgtgccaat cagagttaac actagcagtg 447061 gcaccggcac caatacaatt caaaatatat tcagctggat tttcagaaac accacacttc 447121 ataccagatt gacgttcaaa atacttcaac aaagtttcag aatttggacc aatgtcacca 447181 aagtaaacca tcttaccacc tttctttaac aacaacaatc tgtcaaactg ttcaaacaag 447241 gtagcagagg gttgatgaat cgtacacaaa atggattgac cagaatcagc taaggctctc 447301 atgaattgaa caattgacca agcagactga gagtccagac cagaggtagg ctcatccaaa 447361 aacaataata atgatggttt agcaaccagt tcaacaccaa tagataactt ctttctctgt 447421 tcaacgttca aacctctacc agtcttacca actaaggctt cagcgtaatt ttgcatacct 447481 agcaatgtga taattttttc aacatattca tatttctcct ctaacggaac ggaactttgc 447541 tgtcttaact cggctgcaaa tctcagggat tccctaacag ataattcggc catatgatta 447601 tcggcttgcg caacataacc acatgatctg ttgaaagaag caggcaaggg cttggcattg 447661 actaacatat caccagtgat gacacccata ttgattcttt gtgctaaaac atttaacaag 447721 gtagttttac cagcaccgga ttcacccatc aaggcggtca tcttaccagg cttaacgtaa 447781 ccaaagacat ccgataataa ttttcttgta gctccgtcgt atggaatggt gtagtccaga 447841 tggttccagg tgaaaacgtc cttttctgca atgacctttt ctaaatcgac atttggacca 447901 ttcagagcct ccatcatttc ctctctggaa gcggttcttg catctgcatt ttcggtacct 447961 aactccggca tatgacctct cttatataac agcaagtcac ctcctccctc aacaggtttc 448021 aaatattctg ataagatgac attgaacaca atataaccaa aagtccacac aatgttcaca 448081 ccccaatttc tccaagcatg cttatatgcg aaatgatatt ggtgtaagat gtaagagtca 448141 ccgctaacat acaagttacc cttaaccgca ccagcagcat cacagacttg gttagcaata 448201 gaaatacctt cataaccagg accagatggg actaaggcgc tacacaacat ttccctgtgg 448261 tgaaattcag tggaaactaa actttcaaaa gcataagtta aaggattaat gaaatgaagc 448321 catctaatcc aatgatgcat ttcaccaatt ggcaagacaa aaccagcata aacacaaagc 448381 atcaggaccc ataaaccacc gacggcatgg gcatccacac cagatttact catagtagca 448441 acaaacttga aaatgaaaga agtacattgt tgcacagtca gtagatataa aatatactgg 448501 aagaaagcac cagcttcata tttcataaat ggaatccagt aagtaatcaa acatagtatc 448561 acaatagcga caaatttagt agggaactca gtgataatct cttgtaacga ttccgcagac 448621 aaatggtaca tggaatatga tttgtgtttg acaataacag gtctactaga aaaagagtta 448681 ccaatttcgg ccaaggaagt aacagaagcg aacaataaaa catagaataa cataccacca 448741 cgagaataag cacctgccgt ggtggattga cttttgtcat caattttgtg gaacatagaa 448801 ccgataatca aagctttgat caaaaaagaa cttaagtaga ccttagtata cgttgaatca 448861 cccttaaccc tttgaaaacc acgaatcata caataataaa cttgtgtcca ataattgaca 448921 acatattgag aattttctct ttggccttgt tgcagtcttt gcttcttggc cacatccagt 448981 ctatctctcg tttcattaac agggtgtcta ctttgataat catcataagt tcttaaaagt 449041 tcctgataat cctcagagtt caaccagtat tcctcaaact ctgaactaga ttttggaact 449101 ttatcttcat agccaggttt aatatccaat gtcctatttt caaaatcgac cgtgacggat 449161 gttaaaaatt ccgcagaggt cattctgttt ggtttaaccc aacccattct ttggaaatat 449221 ccaacagctt tatcagcagg accgaagtaa atctgtctac cgttatatag aacagtagtt 449281 ttatcaaata attcataaat attttcacca gcttggtaaa tagcaacaat agcagagttg 449341 tttaccatat ttgtagccgt tctaatggct tgggcaaact ctaaagcagt agaggcatcc 449401 aaacctcttg tggcgttatc ccaagagtag atggaggcat tcattgcctg agcttcaacc 449461 aaggaaacac gcttacgttc accaccagaa acacctctta cgaaatcgtt accgactttg 449521 gtggcatatg tgtgtcttaa accaaaaacg gtacaccaca tatctctgat gttatcaacg 449581 tattgctttc tcgtcatttt gtcaattcta acacgaggag tcttacattt tagggcaaaa 449641 tcgattgttt ccttcacagt aatttttggg aaatggaaat caagctcggg acagtaaata 449701 acgtaacctt tatacttaga catcatttcg ctttggtcca gaccatcata ggagaattca 449761 ccttgtacat caactaattc tgaagtttca ccagatagac actttaggaa agtggagcaa 449821 cctgcacctg gcctaccgac gacaaataac atttcaccag attcaacgac acccgtacaa 449881 ttttgaataa tattccttaa tgggacatca gatttcttgg taaatttact tatgagatgt 449941 gccggtatac tagcaatatt tctaaacatc tcttcaacac taggcccata tgcagcagag 450001 gcatcaacac cgactgctgt taggttttta aaggcaatac cagaatcacc aggttcaatt 450061 ccctgttcca attgacgaga cctcaaataa tgtaatagtg agcgcaaatc aaaatctaag 450121 tcattaattt caaaagagtc catttccttc tttgtcttat gtgaaatgac tctcgccata 450181 gactccaacc tttcaatacc ttcttcattg gaaagaatgt ttgaaaggtg acgggatagc 450241 tgagaagtgg ctgccaaatc ctcattatca acttggcctt cggaggcagc gtaggattgt 450301 accgaattag cataatcatc gtcatggttc gatctcgacg aaatgtcttt ctcaatatgt 450361 tcgtcagtcg aagacatttt tttattaata agaacaataa caataaatct gtaaaccttt 450421 tttttaagtg aaaattagta actgggaaaa cagagagaaa aaaagcagaa gaatatattg 450481 attgaagaat aaaactgttt aacgttcccg tttatttttc agattatcct attgttatac 450541 tattatcgtt cttagtcttt tctttatatg ataaagagaa ccccaaaaag agaactacct 450601 tgtaccatgg ttgttaataa aattggattt gttgatatat ttatatgatt aacatttcat 450661 tcaggataga attgcctaaa aggtaagaaa taatcataag aaccgtcgag aaaatgtgat 450721 accgaatccc tgcggtggac gtggctaaag aatagtgaag aaaaaccggc tgtagtgtat 450781 gttttgtatg agccatagcc gaaagatcga aaaagtagca gatcccaaac actttacgga 450841 aaaaaatcga gaaattccgg cgaatcggct cttaacggat gcagggtgtc agtctgatga 450901 gccataaaaa gaaagatgca ccattgccaa gctgccctga ggaagggttt tggttaccct 450961 gtgagatgga tgcggtaaaa tgaccaaggg accggttggt aagggaccag gttaggaacc 451021 gtgagcggcg aaaaaagcgc gcatttgcac aattatatta ttaacaggtg cctgaatttt 451081 aagaaccgtc caccatcaca ggtgaaacaa atcaacagag tcctgccggc tggtaaacaa 451141 tccatctttg gtttagaggc cactatcgtc agaataatat aaggtctatt ttcggcgcga 451201 aagtcctgat gaggtaaatc gtagtcaggc gcctgaaagt ctaaactaaa caattgaaag 451261 ccgaaaccga aacgcggaaa agtaaatggc actcttcgag cggctactag tcgagtaatt 451321 acatttctaa attagtctgt gcaataggga aaagagaaca ttcttactcc gttgcgatgt 451381 ttctgagcat aaggcgcgcg caaaagcacg cacgcattga ccggagcggc gcccacacac 451441 ggttgttatc ctagtttttg ttgtgaggaa gtgttcatat tcttttaggt tatatttata 451501 tatatatata taaaagttga atgtaaaatg caaaacaaag atatcgtagt atagagggta 451561 atatcacagt aataaaacag gcctggtttg aagaatgatt atgttgatgc tggaggtcgt 451621 aaattgtaac atgaaatagg gagcatgcga aaaaaaaaaa tgacgagcaa aaaaagcaag 451681 gtagacaggc gtgccaagcg gagtagtatg tcgtaagaag cgagcaaata gtactccttg 451741 tcttgcaaag tagcgaagta caagactggt cttcaggctg ctagagattt gtatcaattt 451801 tgtatttttt tttcatccca tgcaattttc cttcccattt cttttgcttt ttttgccgcg 451861 aattgaaata taaagtctga tatgaattgt tggagtcata ccattctctt acgagctgtt 451921 atttcccagt gagtacttag aagaatcatt cttttctaaa tcgtaaacat cacttttcct 451981 tgaagatttt agtaacacta tgtttgtatt ggaatctttc ctcaatcgtt tctgctgcct 452041 tgccagcaaa gtggcactgg cagtatcact ggtactttta ctcaacttta gtcttaagcc 452101 taatgaattt agaattgtga caaatcttac ttttatagca ttaagtttcc aatttttggt 452161 tagattactg aaattcttgg aacacaacca gcaatagaac gtgaattcac catataggat 452221 aaagaagcca aaaataaatc cggtaacgac gcaggataag atgtggtttt ctagtgcttt 452281 catcaatttt gcatcatcta aatgccatga agagccttta gtaatggaga aaaatgaata 452341 actatgcatc ttgtagtaag caggttgtag gattcttact gtcccgttct taggtatgcg 452401 ccatcttttg tactgcttcc aaataacact taaaaacaac ggaccagtag accccataat 452461 agtcatgtaa gggataaacc agtacttgtc atagtgtttc aaagacttta aagcctttaa 452521 aaagaaggga tgtctaggca cagaacccat gacatcgttt gagacaccta aaggtgaagt 452581 ctttcttaag aaggccggga aagctaacaa aggatctagt ttcctttcgc agccgtcatc 452641 taaatcgatg tatacaccac cataatggga caggataaag taacgaatgg catcggcacg 452701 ttctatgggg tatttgtagt tctcaaaagt atcgagaaac cacgggtatt cttcctttat 452761 aaactcatag gccatctcgt ccgtccatag gatgtacttg taatctggat gtagatcgag 452821 acatttttgt ctaccctctt tccagtgctc agggatgtct tccgttttat aagtctgatg 452881 tatgatttta ggtattagtt gaggctttgg aggtgcatct ggatttaagt cttcctcaag 452941 tatagcatct ttaacagtat cgtcaataca caacgttagc aaatcgaaag tgtagtatat 453001 tatagataac aggaggagta tgttgaagca gataaggtat tttaattctt ttctcatcgt 453061 gagtgcaaca gcggaaaatc agaaaaatag agtaaagcaa atatgcgaaa atgaaaagtg 453121 tcttccgatt tattgtttgt ttgtatgtgt ttatttgaat ccgatgatga atattacaac 453181 aggttaaaga aaacaaaaca tgcgaagcaa aatatgacgg gaatgttggc accttttatt 453241 taactatatt agaaaagaaa aagcagaaaa cgtaaaatat ctgcgtaagc ctcctccctg 453301 tgtcttcact cctctaacca ttttttccaa gtagaaaagt ttatatataa caagagggga 453361 aaaaaatgtg gaaattggca gtggacgtga gaacaaaaaa gcaccgctga aaggcttggc 453421 caaggaagtt tagaaaggcg ataataacga ggtaagaaga aagaaaaaaa aagaaaaaga 453481 tggcttagca aaagattggt ttttatcccg ggggagttgt tgtggccggg agcaagagaa 453541 gagacgcagc aagcgtgggt caatgataat gacgcagcgc gacgcgacgc gacgcgaatt 453601 caaaagtgtg agtttgctcg gggatagtaa taatgcgggg gggaagacga aacagaccgt 453661 gtgtggtgtg ggtgggattt cgtgggagca cgtggcgagc agaggaagag cctcacacaa 453721 tgctgcgttc ttcataaagg ggatcaaagc aaatagataa tcgattccaa agacagatgg 453781 ctgacacgca ctttcacagt ttcgcagttt tttctttttt cgtagtcgct ttcctagtcg 453841 ctttcctggc tctttaccta atcgggctta acctagcagt accttttctc gattcatgaa 453901 atcaaaacgc tagtcacttc cttataattt cctttttcaa tttccgccgc ttgcgtttac 453961 gtagtttatc tatttatagg tacggtatac cctactgcat taataacaat gagtccagct 454021 tttcttgggt cagttgaata tttaatgcat gcttgtcgca ctggttattt aggagccgca 454081 attctagctc attagaattg atttttaggt ttagttcttc caaagcggaa tcgatggaat 454141 cgctctcttt gaaaacttcc ctcgcctttt cacattcact ttcggtgttg tttgtctttt 454201 tcacattttt atcaaaatct gtcaagtaaa taaaggggga atctttcata tctagtattc 454261 ttttcttctt gacgacgctg ctgctagagc cgtcgctgtt acttctattt tctggtacgt 454321 gtactgggta accctttgca taatagccat tcgatggggg aggcggtggt gtctcacggt 454381 ggtggtaatt attgtaagta tggctgctgg aatatggata agcactgctg tgatatgatc 454441 tattgttggt tatagacgat actgaaggtg gtggcggaag cccgttgctg gtgctgctag 454501 tgctgctgtt cccactacta ccatttctgc tgctggtgct gccaacgctc atcggttgtt 454561 ggcgtggatg atctgcctgc atgttccggt atctggactt gactcttttt tcgtcattat 454621 cttcttgcga ggcgctcgtg gtcctgccgt tcgtatcttg actattgcca cgttgcggta 454681 ggtggtacga atttgtacca ttgttgtacc tgggggatgg ttgtgcttgg taatgcctgc 454741 tattagctga atagtacggc cttgtatctg tgtatccgtt tcgatagtat gctccggttt 454801 gtctcaagtc tccctcttgg ggcggctgct catagtcact gttgtatctc gcgccataag 454861 acgcattacc gcctctgtaa tacgatccgc ctgctccacc tctacttcgt ctcgcatggt 454921 gataaccccc cctttgtctc ggaggagtgg atgagtatct gctataatta tttcccgtgt 454981 atccgctcat actttactgc ggttttttgg tcacctcttc tgcctcgtaa taaatgtggt 455041 gttctttcct ttcatcgcag ttgattcatt ctctctgatg aaaataagag aaaaaaaaga 455101 acttcacagg gtaatggccc gtacaaagtg tctttttttt caattcggaa cggcggaatt 455161 ccccgccact cttgccccgc cccttaaaac gccaaggtga aagggagctc tactacaggc 455221 ccgccacagt atgatgtggg ataaaaaaga tgataggaag aaaaggtgca gacaacatcc 455281 tgtatggggt gcacggtgtg gcagtgctag taataaaatg atgtggagat taacatgttg 455341 tggtacggta ttcttatctt caaggtacca cagtataatt ctgcctttat cattttttat 455401 ttgtattatg tattttcgtg cttatcttgt aatttttaag ttttggattt cggtgcttcg 455461 tgtagttctt cccctatatc tcaatctaaa gtaaattatt acaaaatatg gtggtgatct 455521 tttaatctca aagcttcttt tactccgggc attataaaaa cagaatctct tagcagttac 455581 tcttttccct tttctcttgt gccgtcatat tagagtaatt ataatttctt ctttttcggc 455641 ttccccttgt ttctacaaaa tctcgatttt attatctaac actatcataa ctactactat 455701 tactattact attattatta ttattataaa tcttaaaact attatttgct aaaacaaaat 455761 ggatgctttt gagaatatgt ctgtatcaaa tcatccgggc ggtaacgcaa gaagaaactc 455821 ccaatcagca aacgaaatgc ttgcatcgca aattcaggat ttccagaata ttccaaggtc 455881 tttcaatgac agcaatgcaa atgtaaattt gtcaaaaaat tgtactgtcg gcaatcaact 455941 gcctttctca tcacgtcaac aaaaaattat catggaacat ttactgataa cgaagaacaa 456001 ttctcaacag cagaaggact attcacacgt gccatgcaaa ttttttaaga tgggcaattg 456061 ccaagctggc tcgtcttgtc ccttttccca ttccccagat attatcagtt ctgcgaataa 456121 tttaccttgc aagtatttcg caaagggtaa ctgtaaattc ggtaacaagt gtgttaatgc 456181 tcatgtgctg ccaaatgggt tcaagatgaa cagtaaagaa cctattgaca tcactccccc 456241 ttcacaaaac aactacttat cccatgctag atcagcttct ttctctacct acacgtctcc 456301 tcctctgtct gcacaaacgg aattctctca ctctgcttcg aatgcaaact acttttcctc 456361 gcaataccta atgtattcgc ctcagaaaag tccagaggcc ctatatactg aattcttttc 456421 tcccccttcg tcttcttctt cgtacatcaa ctatagctat aataactcca acattaatgc 456481 ctattctcca gtctcttcgt cttcatctaa catttggcaa gagcaaggcc aaactacgtt 456541 atcgaatccg agtgtgaatc agaatttaag gtatcgtaca ggccctgcaa ttcaagaaga 456601 atcagataat gaaattgaag atttacttat tcacaatttc aattccagat actgtcatga 456661 atgaagagcc gccccatcca tagtttttcc tagttcaagc attaatatac cggaccactc 456721 tacatcttcc gaaagccgga aaataagaac aaaaaataat aaaaaaaagc acgtttaata 456781 taaaaaacat ttcattgtat gagttggatt cttttaattt tattttaaaa tacggttgca 456841 ttttgcatag taatatccaa ccaattattt actgaaattt gaaatttgat taaaaaagtc 456901 aaaccaaaaa aactacgaca atacatgaag ctctgaatct tctagcctag tcattttata 456961 tatatatatt cacctcctct cgatacgttc catcataagt tagttttgtt tttctctttc 457021 tcgcgatcct aattaaaaat taaataaaat aaataaatac atatgtatat atattcatat 457081 gtagaagatt attgttctta tacatcagtg ttttgattta tggtaaccta tcccaacctt 457141 ctggcttatc tttcttcata atgtcgaagt aatgtccgcc acatgaacca cttctaaacg 457201 tgaaatcgtt accctggtca cagttacaat tatattggtt ccatatatca tcgtttaggg 457261 gacagttatt gtacttgtca taatggaatc ctatattttc gaaaaaatgt attttatcct 457321 ttggcaacag catcgataac ccaattgtgt ggatgatgga atcagaccat ttccagtaga 457381 aaataccgcc ctcttcgtcg atgtaattaa aaaatttcct gtaagctggc gatctataaa 457441 agttcaaatt accaatttca aaatttgatg tgaattcaca gttgttaaaa tcttcagagt 457501 ccttttttgt aataaatgac ttgaaattat tctcggaaat aaactttgga aaatcctttg 457561 caaatttttt cgtaacatcc caaatcttct cattggcttc cttagcttca ctcatactca 457621 atgtgaaacc aaacactttg ccttcatctt gcatccacct aaaaaggtca tgatcaatat 457681 cacagtacaa tttaatacca gggtctactc tccagtacca atcaaactca tccagaactg 457741 gatgcctcca aaaaaaccct gcaaaatatc tagcttgata tcttacagct ctagaatcac 457801 catccggtac atttgctaat gaaattagcg attctgctgc tttattttca tcaatccatt 457861 cagggtatac ccattcgtct gcaggaattt cagcaaattt aatattaatt aactcaggat 457921 caccattcat agaatcagtt atggcttgac gaatcatttc ttgcttcatt ccgtcaagct 457981 ccccctgact aataaaaacc caaggataag caaaattttt gttaaacttc acctgcactt 458041 catcaataga ttgtaagatt tgggtcatgg aatccctttc agtaattagt gagacaaagc 458101 acgcctttgg tggtgatcct ctatgattga tatacgatgg caccatgaac cctagcgtcg 458161 tttcattacc accataagat ttgatctttt ccttaatggc attcacggtg gcatttctaa 458221 tggcctctcc ctctaaagat tgcttcaatt cggcttcttc ctgttcactt tgtatacgcc 458281 tttgttcctc tgcactaatt tttgcaatag gttgcaaaga tttcggaagg tatggtgtaa 458341 catactgttc agacatctgc tttgtttttg gatgatttat tgtcaccatt agcgcaagca 458401 cgaaaacaaa cgaaatcaac agaaagcgtg ctattttttt gctcagcagt acgtgcatct 458461 taccttatct tatcttcact aaagggcaca aaaggttggg tgaacgctta gtatccctct 458521 agtcttgtat actcgtacac attataagta catttaacaa atctcatcca catttctcga 458581 ataaatatca catgtaactt gaaggttatt tttatatttt tttttcctgt gaaggaacaa 458641 ctcgtgtctc acgagagcgc cacttaaaaa acgaaaagat aatcggcgat gactatatat 458701 gtatgtgatt gagaataaaa atatggaaag ataaaagacc tagtaacgtt gtatttcaat 458761 agtgaggata acataaagaa gtaaaaagat ctttgaaaat gtatgaagta atacagaaaa 458821 ggaaaacaaa aataataaac gttttacaga gtcctgaact catgaggctc atagaggacc 458881 catcaaatct gggtatttct ttacattttc cagtaagttc actgctaaaa agtaataagt 458941 gcacaccaat gcctaaactt tctacgtata gtttggctag tgggggattt aaggattggt 459001 gcgcgtgaca tccctctaga cgttccacca gagattgata tcatcgattt ttactgggat 459061 gttattttat gcatggaatc tcaattcata ttagattaca atgttccgtc aaaaaataag 459121 gggaacaatc agaagtctgt tgctaagctg ttgaaaaata agcttgtaaa cgatatgaaa 459181 actacgttaa aaagactaat ttataatgaa aataccaagc aatataaaaa taataatagc 459241 cacgatggtt acaattggag aaaactaggc tcgcagtatt tcatactgta tcttccccta 459301 tttacgcagg aactgatttg gtgtaaactt aatgaaaact atttccatgt tgtattacca 459361 tctttactga atagtaggaa cgttcatgat aaccacagta cctatataaa taaagattgg 459421 ttacttgccc ttttagagct aacttccaac ctgaaccaaa acttcaaatt cgaatacatg 459481 aaattgagat tgtatatttt aagagatgat ttaattaata atggtttgga tcttttgaaa 459541 aatcttaact gggtcggtgg gaaactgatt aaaaatgaag atagagaagt cttgttgaac 459601 tcgaccgatt tagctacgga ttctatttct catttattag gtgatgaaaa ctttgttatt 459661 ttagagtttg aatgctaagc agttatattc agttagaagc atatatccca ccattaaata 459721 agttaacata ctactgcatt tttattttat gtttaagagc agatacgtca atgtagcttg 459781 catatgtacg tatcctcccc cacctcctat tttctacttt gaactttatg ggagtgttag 459841 tataagaaat atgtttacac ctttttcaga caaatgtaaa cggaaaatta aaaaacgaat 459901 tcagatcgat gtgttaatca agtagatgaa ggagaataaa gcatataaag cgcaccgcac 459961 acatgtttca tttagtcaag ggactttaca ataattggaa taaaaaggaa caatattcaa 460021 ttctaatatt aggtctagac aatgcaggca aaacgacgtt cttggagaca ttgaaaaagg 460081 aatactctct ggcgttcaaa gccttggaaa agatacagcc tacggtagga caaaatgtgg 460141 cgacaatacc cgttgacagt aaacagatct tgaagttttg ggatgtaggt ggtcaagaat 460201 cactgagatc aatgtggtcc gaatactatt ccctatgtca tggtataatt ttcattgtgg 460261 atagttcaga tagagaacga ttagacgaat gttccacgac cctacagtca gttgtaatgg 460321 atgaagaaat tgaaggtgta cccatcttga tgctggccaa taaacaagat agacaagata 460381 gaatggaagt acaagatata aaagaagtat ttaataagat tgcggaacat ataagcgcta 460441 gagatagtag ggttttacca ataagcgcat tgactggaga aggtgttaaa gacgctatag 460501 aatggatgat tgttagacta gaaaggaata aaaagtcaag accaccgatt tataaatgat 460561 aaagaagcac caaaagaaat aaaatgtgaa tggtttattc tcaagctcag aaattagttg 460621 ttgtagcact ttttattcgg cattttttaa tatacatgtg taaattatat atatatatat 460681 atgaatatat atcttgtttt gtttattttc aactaataat cgcaacaata ttatctttca 460741 ataacgctat agcttctgta tgctttttgc tcagttgctc aatggttctc ttcctctatg 460801 tgataaacca aatagtttgg taagccaaat acatcgtagt ttaatctctt cgccatctta 460861 gcaaaacctt ctgtttcaat caagtgataa aatgggaaat tagggaacat ggcaccgtct 460921 ctgtgaactt ctgctttgac caaagtacag cctccaccaa caccatccag cgccatctct 460981 tcacctggta cgccattagc atcgtagaaa tgagccatta atggcctata agtggcaatt 461041 tctgcataac cctcgacaat aatctcgtca tcacccatct gagaggctat ttctaaaccg 461101 gtgtcacttt cttgccagtt gttgaaatcg tatggtctga ttgatggttg cttcttctct 461161 tcatcgtaaa atctttgata aatgtttgca gctaagatag ctttgttgtg tttggtcatg 461221 tcttgaatta aagatggtgg tgtctctata atatcggcat ctagccacag cacccaagaa 461281 gtgtgaggtc ctatggtgga gaatagtaat tcattgcgcg ccaaagccat tgctgcacgt 461341 ctttcctttt gaacatctaa agcgtgtctt tccttctcca tcaacttatc aaaactctgg 461401 gaattctgtc gcaaaatagt aattttacta aatctttgag ttttcttgtc cgtttgaacc 461461 tttttaatag cattctccaa tttctttaag gccaagtcac cagtggctgt tcttggtgta 461521 atgaacccca attcaatcaa ttcccgaggg taatttagct gcagcaaatt gtcccagtat 461581 tgttgatgaa atgtttgcat tggagtcaat atcaaaatat gctccttatt gacagctgct 461641 tctgacgtag agtgcaattt gttcaaatca taatgtgcaa tatgaccttc tgggataata 461701 tcttccacgt gatcgttgaa caaccagccg ctttttttct tataagagta ctttggcatt 461761 ttgtatttct tggtgaaggg aaaataaaat gtgttttcct tttcgtgtgc ccatttgtgt 461821 tgggaaatgg actggccatt aagtcccaac agagattgat ctctctggaa aaaaattata 461881 tatattagaa atatggccaa aacaggtaga aaaatgttaa cccacgggtt ctttcttagg 461941 cggtacgata caagagaaag tgacattgtt tcctaacttt ttattctagc tcttttaaat 462001 tcttctgttt gaaaaatact aaaattgatg ctattctctt cttactttca caaagtgcgg 462061 aaggaaaaat aggttcagaa ataacgggtc ccaagagcgg ctaacagaaa ataataaaag 462121 cttttctacc aattgagaat ccgcttggtt gacgactttt cctcctttat tattcttgat 462181 ttggtgttct gttttactta tatcaaaata cttcaacgcc aaatccgcta caacgatgga 462241 aaggaaaaaa aaaaaaaaaa aaaaaagaca aaccaatgct gtcgtgtcta gtgacgataa 462301 aggctgtaac tattaataag gtgaatactc accctcatct tttagtttat caaacttata 462361 taaaaattgt gtatgtactg aattgtcctt ggtgtgcgag tgagagtgtg tgtgtgagtg 462421 cgtgtgtgag taggtgagtg tatgcgagtg tatgtaagtt tataagtgcc tgtgtggcta 462481 ctattttccg gttctgtgat gtgatgatga tttttttgtc agctcctttg attcattcca 462541 tactttatta catatgctca taaacatttt cttgtctaca ttgctagagc tcagggggaa 462601 ctcgaaggca aaaatatgcg atgagagtcg gatttcgcct tgaagaagac taggtgattg 462661 ctgctgcggc tgcgaggtcc gctggaacgt agtaaaagtg ggagtgggga ccgctccgtc 462721 ctcgatggcc aagtccgtac cctcttcttc gtctttattg ggttctgcct catgccatga 462781 actcctgtcc cggtttgtgc ttgtgcttgt acttgtgctt gtgcttgcgc ttctggcttt 462841 cgtgttggcc gagagtaatg catcccgttc aaagtggtat tcttcagcag gtatcatatc 462901 tgctgggcgt agatccgcgc gctgttgcgt aggaccggca ttcgcacttg atcctacgct 462961 agaatttctt gagccttcct cggatcgtct ggttttccca gtggaagcgg tgccactcaa 463021 aggcgaatca tatgagtcgt taaccctctt gtttctgtaa ttgctagcac tatactcatt 463081 ttcttcgtag ggcctagcgt tgccaccttg catagcataa ggaatggagg tccgcggtcc 463141 cattggatat ggatacgaca cgtagggtgt cattatgggc ttgttcagca tgtgaggtgg 463201 agggataccg tacggattat aatatggtga cattatgtag cgattcatgg gcatgtaagg 463261 gttcatggcg ctcatgatgc ccgccgaggg catgtgtggt ttcccataac tattgctgct 463321 attattcact tgtatagatt gtctagaact ggcctttccc aagtattgga cacggggctg 463381 gaacttggaa tgctgagtaa cttgtgcggg cgcgcttttc acgttttgat tagcaacagg 463441 aggaaaatgt gcagagttag acgaagccaa gttgccgtcc ttaatattac caccgtgtgt 463501 attagtgttg ctatccgata aattcaaagg cgccgggact ctgcccctct tcaatgattt 463561 cttcggattc ttcaatggtt gggctttcct cttcttcgca gtggctgtct cagaatcctc 463621 atgatctgct tccttgtcac cagagtcatc ctcctcaggg acatgctcta gctccgactc 463681 ctgaccaacg ctgtttccgc ctggcgaatt cttaatgttg ctatcgctgc tgcccttagc 463741 atttgctaca ctgatttctg tatcaccaat tggatcttgt gttgatttag caatggatgt 463801 atcctcggca gtcgttctca aacgggctga tacggccatt ctcactttct attttcttct 463861 ttgagaaaca ataccaaaat ttgttactga tttgattctt tttaagtgcg tttcttctgt 463921 ataagctaaa aaaacgcaaa gcacaaagcg gaaaaactaa acctaataaa cttcccccag 463981 cgagaaacag atgtaaagaa caaccgtatc aagtggcgaa gcagctgctt ataagtaaag 464041 cccaaggccc accaacgcat acatgcaagg cctgtgcaag ccgactgctg cttgtttcat 464101 cttccgctcg cggtgaccca ctcggggaat ttctcacgct tgctgctgca ggtcgttggg 464161 cgttgattcc tgtttttttc tttcgttttt tcaatccgcg ggagtgagac atgattagtg 464221 tagtccttgt agagttcctt atttattttt ttattagttt tcttgttttc gtttatcagc 464281 agggtttggt tgtgttgctt ggcagcccgc aaattggtct tccctccttg ttattgtatt 464341 ttctgttatt agagcataca gaacatagaa actcaagatc agatacagtt tttgcacgcc 464401 atgtctcaag gtactttata tgctaacttc agaattagaa cttgggtccc aagaggtctt 464461 gtcaaggctt tgaagctgga cgttaaggtt gttacgccag atgccgccgc tgaacagttc 464521 gcaagggact ttcccttgaa gaaggttccg gctttcgtgg gtccaaaggg ttacaagcta 464581 accgaggcaa tggcgattaa ctattattta gtaaagcttt cacaggacga caagatgaag 464641 actcaacttt taggtgccga cgatgactta aatgcccaag cgcaaatcat cagatggcaa 464701 tctttggcca acagtgatct gtgcatccag attgccaaca ccatcgttcc cttgaagggc 464761 ggcgccccct acaacaagaa gagcgttgat tctgcgatgg acgctgttga caagatcgtc 464821 gacatcttcg agaacagatt gaaaaactac acctatttgg ctacggaaaa catctccttg 464881 gccgacttgg tggctgcctc gattttcacc agatactttg aaagcctgtt cggtactgaa 464941 tggagagctc aacatccagc catcgtgaga tggttcaaca ccgttagagc ctcacccttc 465001 ttgaaggatg aatacaagga tttcaagttc gctgacaagc cattgagtcc ccctcaaaag 465061 aagaaggaaa agaaggcccc agccgccgct cccgccgctt cgaagaagaa ggaggaagcc 465121 aagccagctg ctaccgaaac tgaaacttct tccaagaaac caaagcaccc attagaatta 465181 ttgggcaagt caactttcgt tttggatgac tggaagagaa agtactccaa tgaagacacc 465241 agaccagttg ctttaccttg gttttgggag cactacaacc cagaagagta ttccctgtgg 465301 aaagtcacct acaagtacaa cgatgaattg actttgactt tcatgtccaa caacttggtc 465361 ggtggtttct tcaacagatt gtccgcctct accaagtaca tgttcggttg tctggtagtc 465421 tacggtgaaa acaacaacaa cggtattgtt ggtgcagtta tggttagggg ccaagattac 465481 gttccagctt tcgatgtcgc accagattgg gaatcttacg actatgcaaa gttggatcca 465541 actaacgacg acgacaaaga attcatcaat aacatgtggg cctgggataa gccagtttcc 465601 gtcaatggcg aaccaaagga aattgttgac ggtaaggtct taaaataatc tcttcgtact 465661 atccttcatg tcgcctttta ttataaagta tgctaggtag ttttatctat atcttattta 465721 tgacgcaata tagggtaaca gagtttttct gctctgaaac ttccgcagaa aaaaaatcaa 465781 gttttccttt tcgtatcttg gattattgtt atataataga tgcatgtatt atatgtatag 465841 cagtgatttg cttattttct tgattctgag gaatcgaaga agtaacttag cgtttcttcc 465901 gttgagcaga gcagtataat aatccttcaa attctttagg ttacggggtt ttcctgttgc 465961 gatgaccgaa gaaactatta ctatagattc tatttcaaat gggatactga ataacctgtt 466021 aaccacattg atccaggaca ttgtagctcg ggaaaccact caacaacaat tgctgaagac 466081 aagatatccg gatcttcgca gttattattt cgacccgaac ggatctctcg atattaatgg 466141 actacagaag caacaagagt cctctcagta tattcactgt gagaattgtg gcagggatgt 466201 gtccgcaaac agactagcag ctcatttaca gagatgtttg agtaggggtg ctagacgttg 466261 acactaggtg gtggtttatg ggtaattgaa aaggcacaga cagattttag cccatttctt 466321 gtgggcatag gttcataaaa aaagcaagat tcttacattt tatgcggcat atctgcacat 466381 agaagttcat gtagttatgt ggtaacatct caaagagaga aggcgaaaac tgttttagct 466441 attaactaca tgtttttata atagcacctc ccatatatga tgccaaatga taccttgcat 466501 tccgttatgt ggaagggtta cacataagta cgctataaca atgcattcaa ttttctacat 466561 atcagagtaa tatgctgcaa catcacaccc atataatata attttttgaa agagttccta 466621 actctttttt gtttttcctg tacctatata ctcaaatagt ccgccgcaag tagcagctct 466681 aacgacattt ctgtcggtat ttcaaactct ggaatctcat catcgtcctc gctaacgccg 466741 ctgtacttca aattataatt taaatattcc acagcctttt ctagaatatg cgagtcaaac 466801 tgcttgagct ctattcggcc tttgctttcc ctgaagggtc cctcaatcat agcttttaac 466861 gtcggtgaaa tcatcgcagc agatcgtgat atctcatatt ccttatcatc ttttgatact 466921 aacgtaacga aatcttgaga catttagtta tggtttttta ttcataaatt tctgacaaaa 466981 gcaaacaata ggaagagttt gttctacctt tgtctgtttt cgacttactt gtgcttcctt 467041 ttttttttta cttcttgatt ttccacttct ttttttttga ttttgggaac gtacaataag 467101 gcaccaaata gtaatatcgc tattaaagtc agcgtaaata ccaaacctat atccctaatg 467161 attataagca atcgtctcca tatcaatcaa tagaggaaaa aaggagagaa aggaatagta 467221 cagacggata ggcctccctt ttgtttcgca ctaataaaaa tgaaaaaccc tagcttcgac 467281 tgggaaagat tgaaagacgt attttataga agcagagcca ttggcgaatt aaaatggcca 467341 actcagtacg aggagttcaa atgtgccttg tcattaactg ttatcgcggt tgaaattcaa 467401 gactttatac aagtatacaa ttattttggg cagctgttag gcaagataaa tttgcaaaga 467461 attcatgagg atataataaa gtttgagttc gataaagacg agaagctgat attggtcacg 467521 aaaagctcca tcaaaattgt gaaaggttgg tcgccactga cgatagaaag tgtcccatta 467581 caggacccaa ccattgatac tatctgggac tatcacaatg gaatcatgtt gttagcaaaa 467641 tctcgtgata tatacaagtt aaacggaaat gaatgggaac ttctttacga gaacaaagat 467701 aaaaaatata atttattgac aaaaaaccac tggagttgca atgatgactc catcatttta 467761 ctggatgttg atcatgtata tcaagtaagc acctcgaacg gggcactatt gaagttaatc 467821 acagattcgt cgtggcacaa ggtaacgatc tcatctagag gatttatttg cctttataat 467881 atgaaggaca ataaactgca gattttcaga gatccagcaa gaatactaat ggaacacaac 467941 ttggattcta caccagatga tatatgttgg tgtggcaatg ataccgttgc ttgttctttc 468001 gaggacgaaa tcaaattata cggcccagat ggtttgtatg taacattttg gtaccctttt 468061 actgtaacta acctaagggc agaggttgat gggttgaagg ttattaccac tgaaaagatt 468121 tactttctat ccagggtaca acctcagact tctaatatat ttagaattgg ctcaaccgag 468181 cctggtgcaa tgcttgttga ctcatttagt ttactggagg atcatgcacc caaagcaatt 468241 gaaatattaa agaattttgt cttagagaag ggtgtactgg actgtattgc tgctgcaata 468301 gacgaatttg aacctaaact acagaagatg ttgttgaacg ctgcatctta tggaaaagct 468361 tctttgcagt acaagtcatt tgacgctagt atatttgtga atgcgtgtaa tacgataaaa 468421 ttattaaact gcttcagaag ttttggtatt tttttgactg tggaggaata caggtgtatt 468481 tctttgaaag gtgtcattga taggctgttg aagtatcaca gatattatga gtgcatacag 468541 atatgcaaat tggccaatga acgatttctg ttaggatacg tgtttactga gtgggcaaag 468601 gataaaatca agggtagtcc tgacatggaa gatgatgagt tactagacaa aatcaaatct 468661 cgactaagtg ttatagatat gacggataca ttacaaatgg tagcagttgc gaaagttgca 468721 tatcttgaag gaaggttcca gttatcccgt aatttagctt tattagagaa aaacgaagaa 468781 gctagaattg agcaactgta taatcttgat gatgatagta tagcgctaaa ggagtgtatc 468841 aaagtacaaa attacagtct gacaatttca ttactgattg cactttccaa aaagctgaca 468901 aactctcaac tgacgaagct tttgatcatt gatatgttca acaatccctt atatctctat 468961 tatatgagaa tggataaagc atacttgtac gatttttacc gccaaactga ccgatttatt 469021 gacttggctc acgtattact gcagcaggga aaagaacagc aatctttaca cagcttttta 469081 ccgcaaatta aggaccttta tagccaagtt caaaacagtg aagtggtcaa caatacaata 469141 gaacaacttc aaagacagga aaagttgtgg atataccaag aatcattagg caaaagattt 469201 gctatatcat tcactaatat gactttagat caaacgcttt cgaagttaat agaaacaggg 469261 caagataaac aggtgaaaga aatagttaaa aagttcaaaa taagcgaaaa aaagctgtat 469321 cacctgaaat gtaaaacgtt agtcgaagct aagaagtttg acgaactact acagtttgct 469381 cagtcgcgga aatcaccaat tggttacatg cctttctaca catacttaaa aagcagaggc 469441 catatggata aagctagtcc ttatgttaat atgatacctg gcctttcgta tcaggaaaag 469501 aaaaagcttt atgtggagtg caggggtttt cgtgatgcaa ttcaactagc aggaaaggaa 469561 aaagacattc caggcttaaa ggagatatat aatattatac cacctaatga gccggaatta 469621 aaggcattag caaatgaaac tatgagcagg atatagaact cataatttat agacgttgtg 469681 gatatctagc cgcatatcaa ataattaaat gctgccatta cgtttgtgcg gttatatatg 469741 ttggctccct atagggttac ccatggaacg gcgaaggaaa aaaaaaataa ttttcactga 469801 aaaatttcaa gagtctatct catctcatcg tttattctga attaaatact acatacaaaa 469861 tctttttatt agtaaaatag tgagatttct tcgtgaacta gtgaaaagct atcaatatta 469921 ccaatctacc aaagtgagat ggaagaaaca atagaaaatg ttgaagtgcc ttctagtaat 469981 gtctcaaaac aaaatgacga cggcctagat atgaagactt tgtttgtgag gtctataccc 470041 caggatgtca cagatgagca gctggcagat ttcttttcca attttgctcc gatcaagcat 470101 gcggtagttg ttaaggacac gaataaaagg tccaggggct tcgggttcgt tagttttgct 470161 gtagaggatg acacaaaaga agccctagct aaggccagaa agaccaaatt taacggacat 470221 atcttgaggg tagacattgc taaaagaaga gatcgttcaa agaaaacatc agaagtggtt 470281 gaaaagagca cacctgagtc atctgagaaa ataacgggcc agaacaatga agatgaggac 470341 gatgctgatg gtgaagactc catgctaaaa ggtaaaccga aattaattat cagaaatatg 470401 ccatggagtt gtcgtgatcc agttaaattg aaaaagatct ttggtagata tggtaccgtc 470461 gtggaggcta ccattccaag gaagcgtgat ggtaaattgt gtggatttgc gtttgttact 470521 atgaagaaaa tcagtaattg tagaattgct ttggaaaaca ccaaagactt gaaaattgat 470581 ggtagaaagg tggctgttga ttttgctgtt caaaaaaaca gatgggaaga ttacaaaaaa 470641 gcccagccag aaatgaatga caaagatgat aacgagtcag gaaatgaaga tgctgaagaa 470701 aaccatgacg acgaagaaga tgaaaatgaa gaggaagata gacaagtaga tcaagcttca 470761 aaaaacaaag aatcgaaacg taaagcacaa aacaaaaggg aagatttttc tgtttttgtt 470821 cgtaacgtcc cttatgatgc cactgaagaa tctttggctc cgcacttcag taaatttggc 470881 agcgttaaat acgcattacc tgttatcgat aagtctacgg ggttggctaa aggtacggcc 470941 tttgtagcct tcaaagacca atatacatat aacgagtgta tcaaaaatgc gcctgcggct 471001 ggctctacct ctttattgat aggtgatgat gtcatgcctg agtatgtgta tgaaggtcgt 471061 gttctgtcca ttactccaac gttagtaaga gaggatgctg gaagaatggc agaaaagaac 471121 gccgccaaaa gaaaggaggc cctaggtaaa gcgccaggcg aaaaagatag acgtaactta 471181 tatttgctga atgaaggtag agttgttgaa ggctcaaaaa tggctgattt gttaaccaac 471241 actgacatgg agatcagaga aaaatcttac aaattaagag tggagcaact gaaaaagaac 471301 ccatctttgc atttgtcgat gactaggttg gctatcagaa atcttcctag agcaatgaat 471361 gataaagcat taaaggcgtt agctcgtaaa gctgtcgtgg aatttgctac agaagttaaa 471421 aataaggaaa gacatccatt gagtaaagaa gagattatca gatctacaaa ggaaaaatac 471481 aagttcatgg gtccagatga gattgaagct caaaaaaaga aagacaaaaa aagtggtgtt 471541 gtcaagcaag caaaagttat aatggaagtt aaaggatcaa ctgcgggaag aagtagaggt 471601 tacggttttg tagaattcag agatcataaa aacgctttga tgggcttaag gtggttgaat 471661 tgtcatgccg ttacctccga tgaaatttta gagggtttga atgatgatga aaagaaacaa 471721 gtagacaatg acttaggcaa aggaagacgt ctttgtgttg aatttgcgat tgagaactct 471781 aacgtcgtaa agagaagaag ggaacaattg aagcaagcaa gaaccaagag aacaagacca 471841 gataatgaag atactggaga tgtcggagaa tccgagaata agaagccaaa aaaagaagaa 471901 gcaacgacgc ccaccaatcc cgatgacaaa aagatgggcg atgatataaa gagaataatc 471961 gggttcaagc gtaagagaaa gcacgcaaaa aaatagaggt agaaccatat ttataggaat 472021 ttcgatttgt attctcttta cgtatgtaca ttatttttca aagagtagat agatgaatct 472081 ctaacgtact cgaaagcttt tatgtcgtta ttttagtact gttttacgag aagcgcgaga 472141 aactctctac atatactgtc cagcatctca gtaaatcata ctgaaacctt attaccagta 472201 tcgctcctag acgttccgtt tgaagtaata ggcaagacga gaattattta tttcccatga 472261 tatacataat ggttataagt agaccgcaaa taaaagtatg taaaattagc tatgtttcta 472321 cattgtttgt gcaatgactt ttaggttcgg ctggtcatta ataactaggt gatgctgaat 472381 tcacgtatct tattagatac atttagaatt catgacttct cctttgtatg agcgtgtccc 472441 tccttttctt gatggtttca gcccttctac atactacaca atgtactttg ttaaccgatg 472501 ataactctac tttatacgta gtttagactt tgaacgggat gaactggttg tttcatccaa 472561 tgttttcgta aagtcattct tttttatgga aaatgtacaa agttgtttat attttttgct 472621 atggttatta acctgaatac cattaacaga tgtgttataa tgggaacata ttactattgc 472681 cgataagtta cgaacaaacc tactactacc attatataaa aattaagggg ggtacttgaa 472741 gtcttttctt tcttcttttt tgggaatgca tgagatattc atatgtttta aagccccatt 472801 agttgagatg aattatgacg aaattcgcat acatctgcgg agaacagggt tttagctcga 472861 cctaaaatca acccattatt ttacctgaat gttgcagact tgcattctta gtgcctctaa 472921 agcgaaaaat tgaaactgta tgccgattta aatactataa agataaaaaa aagtttaatg 472981 aatataatag tgacagtgct gtggaatgaa aaattccaaa tatatataaa aatagaagcc 473041 tatcttctgt ttttctttcg agatggctca tctgatgcat tgtttcctga caccgcagca 473101 gcggctgctg ctgccgcggc cagaattcta cggttaacac caagcccacc taacgcattt 473161 gcagcggcac ctgcggtgat tcctgaagct tgtgtattgt ttttcgttct tgatccaaga 473221 ttcatgatgt cattatcgtt cgtgtgaatt cttcttgccg ggtatttgta agttagacct 473281 tcaaatacat tttcactaac aggaatatca ctttctgtga agtacttatg ttccaacgca 473341 ttaaatgcat ctattctttt aattggatca taatttaaca agtggtaaag taagcttaaa 473401 gcatgcttgt cccttcctcc cgcggaatga taccatgtag caaggttatc cctatacttt 473461 ggaaacttcg taatttgatc atattctgga tacttctcca aataaggcca aattttttga 473521 tcgggagtgc caagaacttc caaaattctc tgtagttgat tcacttgaaa tggaacagtc 473581 tttttagagt ctagtttagc ttcttcacct ttaaatatgg gctgtaatcc tatcagttct 473641 gcaaaaatgc agccaacgga ccataaatca accgcagggg tatagtgccg tgctcccaat 473701 agcaactcag gtgcacggta ccatatagtg acaaccactt tatccccagt atagagggtt 473761 tgcagcatat tatgaaattt tctggccaaa cctaaatcac caattttaac acatccatct 473821 atggtcacca ttatatttgc gggtttcaaa tctcgatgaa gcacccaatt ttgatgaaga 473881 tacgatacgc cgtctaaaag ctgccacata atagaccgaa ccattcttgg tggtatcatc 473941 cttttttcgg gatgggaatg gaagtggata atttgtagca gatcatgctc cgcatattcg 474001 tataccatat ggacacattt cctttccaaa aaaatttcca ctaatgtggt taaatgcttg 474061 ttgtgcaatt ctcgacataa tgccatttct ctacaggcac tctgagatat tcccgtataa 474121 tgcaattgtt cgacgccatc cttctctgtc ttgaactttt taatggcata aaataccgtc 474181 agcggttttt taatgagggt ttgtttttgg gaattatagt gcggggatac atcttccctc 474241 gtagttcgta ttcttccggg ggtcactcct tcatccttta acaagtttct tcttaatgcg 474301 tttgtatttg cctgcatgtc cattgaagag cttgattttg gttgcgtgct gtcaaactgc 474361 ggaattttcg cattggtacc attcagacta gaaccattag cggaattggt accggagttg 474421 atttgtcttt tcgctttgta aactttacca tatgtgcccg cagcaatgta gccaataact 474481 tcgtactttt ctaagacaga tacccgcatt ctatcttttc ttgccctata aggtccaata 474541 gtaaaaacat cattattggc cattagcatc ggggcttttc catgcacact tccgattgtg 474601 tttttctttc caacgaacga ttgagcttgc tgttgtcctt gtacctgcat aggcctttgg 474661 tacattggct gataggagtt ttgtgctcta tccttgccat tatacatttc tctctcctcc 474721 cgtcaaaact aggcggcctt aattcaattg ggaagcaaaa ttactaactt cagtataccc 474781 ttccgccttt tttctttcct ataaaccttt cttgtatcct ttttgtcagc agtgattgtg 474841 ggataacttt caagtattga agcgggaaaa tgaaacgcaa cttaagccac accacgtaat 474901 tcttgaagac ttttgatgta tgatatttat ttcactgtta aaaaaagcta taatttcctc 474961 taatcaaaac tctctaaaac gaaatcaaaa atattcgtaa cacatatata acgaagtaca 475021 atatattggg aatctataaa tcatatgccg agtgcgcaac ttcaactgaa aacaataatc 475081 cgtctctggg ccagaaaaaa aaaaggaaaa aaaagcttta tttcttaata aggtgcttta 475141 atttttgaaa gggaagaagc aaccatttcc caaaatatgg tgctccccag atactaatga 475201 aaatgcgtac cggatatagt aattttactg taacgtaggc tactgtgcca gataaaatca 475261 acttgttttt gttgaggcat tcctgatatc tcttaccaac aaatttctcc atagctgtat 475321 gacagctatc cattaggcca tttaagaagt ttgggagctt aaaatcatca gaaagatcga 475381 ggttataaag taaccaccat agtagaaaca gtggtagtat ggcagttacc tcatgcaaga 475441 tgaagaatga tgtaagtgtt ggaaccgtgc cggcctcact gaggcggtcg aaatagtgtg 475501 aaaatttagg attcttgttt aaccttgtta aaagtcgtga cttggaaaat attttacgta 475561 gtctatcctc ccttcttttc actggatcta aatttcccga tatgaatcta atttgggttg 475621 atccgccggg cctggtgttc ataaacgtgg tcaattgcgt tggcctttta agcatgagct 475681 ccaacggtcc agagcccatc tgcagttgac agggcctgaa gaaaagattc atgacagtca 475741 tgttcctggt gagggtgcct tgggtgtaac acttatcctt acacggtctc tcaaaagcaa 475801 tatttttaca tttctcttct ttgcttcctg ttcgtataac gcgctgagag ctggtaagaa 475861 caataggccg aggccctgca tcaaaatgtc agtaggggac ctgttaggta cccactaata 475921 agtacaagag ggtttttatt ttctaagagc caataattgg cattctttat atacaggaaa 475981 ggtacatgtc attcaagaca tgagatgatc cacagcttct ttacatctgt cacacaattt 476041 atcctcttcg gctgagttgg ccttccaaca tctgggacag ttgtgccttt tgcttcgttc 476101 aaccaatatt tgaacgttta ttccgcttcc caattcaata gttggtagac tgttattatt 476161 atcgtccatt tgcaatatat caacagcaga tgattgcaat atgtcgcaaa gctcgtcaga 476221 actgaatggg aggtgatgct tggtgaaaat ggtaacgtga ctatgtgttg ttttggtgac 476281 accttcttct agacttaacc tcttgaattc ctcctggaac tgttttagaa tttttagttc 476341 aaagttttca aaggaggtga cgatttccgt atttgagtcc aaaaacggcc attttccacg 476401 catcggatta atgtctatat gttcttgtcc ttgtaaccat ccttctggta tatacttcca 476461 tacttcttgg accataacgg gtaatattgg tgcaagaatt gccctatatg catttagtat 476521 atggacaagc gttgtttgga cctgccttct tgccaatgac gatatttggt tggaatataa 476581 aatatccttt gagatatcaa aataaaacgc cgatagctcg ttatttaaat gatattgtag 476641 agtaatgaga accttggaaa agttgtactt ttggtagtgt tctctcgtcg tttccagcag 476701 ttcgtttatc ttatacaagg tatattgatc aacacggcgt aattgttcaa tcggcaaaag 476761 gttgaaatct tgggacttct gtaaattact caataaatag cgaaaagtta gtctaacctt 476821 ttttagagct tctcctacat gtttcatcac agtcgggcca gcaactatat cagttgtgaa 476881 attcgattgt gctatcagat acctcaagcc atcaacaccc aaagctggta agcctaagtt 476941 ttcatcgcct cgaattattg cttcgggaga aattgtattt cccacagatt ttgacatttt 477001 cagaccattc tcatctaggg taaaaccatg agtaatcact tcttcatatg gtgcaacagg 477061 gacattactt gatgctactt ttgttagcag tgaactttga aaccatcctc tatgttgatc 477121 agatccttct agacaaactt ggtacagggg ggatgggagt tttgacaact ttaagctttt 477181 ttcataaaag tctttgatca cactccatga cgacccacta tcaaaccaca catccatagt 477241 atcttgagaa cgacagtatt catgcgctac gtcgtgatat ttttctggca accattcttt 477301 catgtcatta tctttatcgt taaaccatgc attaattcct ttttgtttga ttttttctat 477361 ggcatgtgcc aaaatttctg aattcatcaa aacagaatcc ggttcgctct tcttgtaaaa 477421 gcttaatata gggatacccc atgagcgttg cctagatatg caccattcat ttctgctttt 477481 cataaaggat gaaagtcttg aatagcctct tttaggacaa aacttgacgc ggctgatgct 477541 ttccagagcc aagtttttta catcgtgtaa atctgcaaac cactgtggag tagctcttat 477601 tatgacaggt ttcttggatc tccagtcgta cggataagaa tgcgtgtatt cgtgagattt 477661 gtaaagtaaa ttaaggtcgc ttaacttaca tagaatgatt ttcgcggttt cggcatccaa 477721 tacttgccta ccttttgtta agtctccttc atctctcacg atggatctga cggactgagg 477781 aagttcattt aattggtagc ggccctggtg atccacggga gaataaattt caagaccatt 477841 ttgaatacca atgagatagt catcctgtcc atgccctggt gctgtatgaa ccaatccagt 477901 ccctgtaccg ctggtaacgt gtgcaccatg taataagggc ctgccaacct tatcgtctac 477961 taagaggttt tgataatata gcccatttag atgagttcct tgaaactgtt tgatagtctc 478021 aaatgagtta gttgttaggc ccaatttatc aatggagccg gtctctacaa ggataagttc 478081 actatttaag cgtaataggg agtaggaaaa atcctgattg aaacagattg ctcgattaga 478141 gagaagagtc catggagtac tggtccaaat caaacagtat ataggcaagt tattcgttat 478201 tcctagtttt ttgcacagat ccatctggga tttcttttca agaggaaatt taacataagc 478261 agcgatggat ttatggtttt cattatattc taattcgccc tctgctaacg ctgttctagt 478321 ttctgtaccc cagtaaaccg gtttgttctg tctcttaatc agtcctcttt cgtacatttc 478381 tttaaaaata tttagctgat taatttcata gtctttatcc attgttaggt atggtgtttc 478441 ccagtccgtt aagatggcaa aatgttggaa agtttccctt tgcctcttga ttgccttttg 478501 tgcatgtttt aaagccattg acctgatttt taaaggcgat attgactcga tctgttgcgc 478561 gcttaaatct ttcaaagctt taatctcgat gggtagtcca tgacaatccc agccaggctt 478621 ataaaaaatg tacttcccct gtgaaagttg atatctgttt atgatatctt tcagaatttt 478681 atttagagca tgaccgagat ggagctcgcc gttggcatag ggcggtccat catgtaagat 478741 gaacaacttt tctttaatga actctaattt ttcatcagtc gtattaagct ttgaaaattc 478801 ttcgaagaaa tcacgtagct gctccttgta aactaactgc gaagattttg gtattaattc 478861 cctcaatgta atctctaagt ttgatctatt agggaatttg gtcttgggca agtttaatgt 478921 tttttggtag gcatgtttgg cgagatatcg cttgctaata atgctaaaga tatgttgagg 478981 cacaagcctg gagcgcttca taagtagcta aagatcgttc ttagtatact gtgttccata 479041 acttctagcc ttggtccttt atatttgctg tttttctgcg tttcttaact cgcttgcgga 479101 aaaagaatcg acattttcag aacaggattt tattgttttt aaagtacatt atatggggcg 479161 acacatcatc gccatctatg ttaaatattt aaagaatacg gggtagaatt attcacgctg 479221 ggggatgctg aaagaggagt ataatttgag cggtgctgat aacatggcat ctgctgagtt 479281 gtcatttaaa aagcaaaaag tggtattgaa aaagttcatg atagcgcaag tgactaaggg 479341 gattatgcag cggtatgcga gcctattagt taccatgcct agtgatgatg acaatgcaat 479401 tattggcaca aatcatttga aaacaaccaa atttttagaa ataatcctac acagagccaa 479461 atcatcgcat ttacagttca aaaaggtctg ttgcattgtc atcaagtttc tagattgctg 479521 ctcgaaggaa actaactaca tgaagttttt aaagttcagc ttacacaaac tatttgtagc 479581 tgctttcatc ttaagtgtgc caaatgttgt aggcgatgac cgcgacagga ttaccacgag 479641 ggatgaaacc tatcatctct attcccagat aacaggcttg ccactggaag aagtgataaa 479701 ttgttgttct attgtgaggc ctgtacttat tcggcggagt agacaacaac gcaggcaaat 479761 gttatctcga cgtgaacaac attcgtactt cctcagaagt tcttttatga actccaattc 479821 atcagcatca ccttttttct ctaccaatag gtcagctgat gatctacatg tacatacaag 479881 ggcatactcg cttcatagcc attccgatgg ggaaggccaa gataggcggt cggaacatga 479941 agaaacgcat agcatggggg ctgatgccga tacatatcga caaactacgt ttatcccaga 480001 cacaccaaat ggtttgcatt ctagatcatt aattgagtgt gggatcgaac ccacccaagt 480061 aagtgactct ggtgaatggt cgggtcaaag taacggatat gttttggtga cagaattaca 480121 ggagtttaac aaaatgggta aaaagttagt acaagaagct tttaggatag tttaataaag 480181 tatggtttgt cgttttgttc atcattcaag ggtcattttt atttccattt atgatttctt 480241 gagtacaaaa ggcaaaaaaa acatgtataa ttatacacaa gaaaaaaaaa caaaacaaaa 480301 gaacactttc acacaagcaa gtatatatta tgagaatttt ttcgagtctt acagaaccat 480361 atcttgcctc taaattttag tctaaaaatt ttgctagccc atcaattttt tttttgttct 480421 aatgcaaaat ataacatggg taagaaaaag aaaaagccgt tcctcagtac gtaaagagat 480481 ttgatcatta acaagttggg ctcaatatac acagtcgata gtctatatgt gcatatgaaa 480541 ctggcgcaag acatgaatgt agatgaaata tttctcaaac aagcggcaga agctatagcg 480601 gtaatctcat caagtcccac tcatacggac cccataatac gagagctact ccacagaatt 480661 cgacaatcca gcccattgag cgcagttata ccagcaccag aaaatgtttt aaaggctggg 480721 gagccggaaa atatggctag aggtcttata aggattccag aaacacaaac aaaaagaaca 480781 ggaggtaaca accatagcaa ggaaggcgca cagctctaca gctgtgcgaa atgtcagttg 480841 aaattcagca gaagttctga tctgagaaga catgaaaagg tacactcact cgtgctgccg 480901 catatttgct caaactgtgg caaagggttt gccaggaagg atgctctaaa aagacattct 480961 aacacactga cctgtcaaag aaacagaaag aaactaagtg aaggttcaga cgttgatgta 481021 gatgagctca tcaaggatgc gataaagaat ggtaccggcc tgttgtaagg ctagaggaaa 481081 acgtatttgt ctccatcagc acacctacac atacatatat agatagatat atactttagc 481141 cattgagata agtagaataa aaaaacgttg taatattccg atacagttag tgacatgttc 481201 tctacttttg ccaatttttt gcgcacaaag tggtgacgta caagttcatc atttcacgtg 481261 tgcagcatag tgtggtatat tgttttttta tattttattt tttatttttt tttttttgca 481321 gaaaacagtg tttgtattat atgctttaga tatgctaaaa aaaatgaaaa aaaatggaac 481381 aaaatatgtg tttttttatt taacgttaaa attaaagatt aagttattta ttcgacgtca 481441 gcatcaaaag tttgaccttc aactaactct ggaatagctt catccttctt ttcagcatca 481501 gctggagcct tggcttcgtg cttttccatt tgggcagcca attgagacaa ggcttggatg 481561 gcttcagggc ccaattgaga gataatacct gggaacaaat cttgcaagtt cttttcctgt 481621 ggtagaccgt agaatacaga agtgttgtgt tgagcagcaa cttggacacc gaccttgttg 481681 aagtgcatga ccttaccgtc gtccttgaaa aagttggctt cggcgacgtt gtcaatggtg 481741 acagcgtgca acttagctaa ttgactttgc aacttggtgt catccttgtt ggcaccggca 481801 gaagagcctg ccttcttgtt aagctttctt ctagtaccac caactttgtt gttagcagac 481861 aacttttgta gcttagctaa tttttcttgg tcaattggca ttatgaatta tgagtcgcgt 481921 ctggtgtgag atgttctatt cttaaacctc cctagaaaga atattcgctc tcttgtgaca 481981 aaggaggggt tactacttaa caagcaattg cagctgtttc cactacgaaa tcttccaatg 482041 tcaacgaaaa aaattcaaaa attttctgct ttttttttca acatctgccg tactaaatga 482101 ttccacaata atccatcata taccattacc ctgattccca tcgaagaaaa ggcggtgtcc 482161 ccttacccgt ccgctcatgc caagagatta attcataacc gctcttcctt ggatcagaag 482221 tgaacatatg aagttgcaac tactacatac ttactaccgt agtccatcat caaggaccca 482281 aacattcacg actccagcgc gccacgttct tcgccatact gcttaacatt ttggtacgag 482341 tgcgaattag ggaagtcgat gataaaatag aatatgcgaa aaagaggaag agcagccgtg 482401 agaaaaaaga aaaaaaaagg cctaaggtat tctctactcc aaaatcgtcg agggagggca 482461 aaagaaattt tttttgttta agggaattgc gaagtcaatt gattgatgaa gtagcttctc 482521 tggaaaaatg gcggacagac gctgctcaaa taaccgtcga agggggaaag gttatcggtg 482581 gaaacatatt tgtaagtaca taatagtgaa tttacttctt gtcggcgtcc cctaaacgta 482641 attggcggtg tgatggtact tcgttatata aaggtgtgta atatcctctt ttaccatcta 482701 ttatttcttc cagcatttct tgctggataa cctactgtat ccaagctact gggctttttt 482761 aaacataccc ataacttttt ttttttcatt tttcgttgct gtgtgctagt acaatttaag 482821 caaaaggaaa ctgttttgcg ttatgtcttc cactgaagca aagcaataca aggagaaacc 482881 ctcgaaagag tacctccatg ccagtgatgg cgatgaccct gcaaataatt ctgccgcttc 482941 ttcgtcatct tcgtcttcta catcaacttc cgcctcgtca tcggctgcag ccgttccacg 483001 gaaggccgca gccgcttctg ccgctgatga ttctgactca gatgaagata tagaccaatt 483061 gattgatgaa ctacaatcta actacggtga gggtgatgaa tctggtgaag aagaagtacg 483121 tactgatggg gtgcacgctg gccaaagggt tgttcctgaa aaggaccttt ctacggaccc 483181 tgcgtatggt ttgacttcgg atgaagtcgc caggagaaga aagaaatatg ggttaaatca 483241 aatggctgag gagaatgaat cgttgattgt gaagtttttg atgttcttcg tagggcctat 483301 tcaattcgtt atggaggctg ctgctatttt ggctgccggt ttgtctgatt gggttgatgt 483361 cggtgtcatc tgtgctttac tgctattaaa cgcatctgtc ggatttattc aagaattcca 483421 ggcaggttcc atcgtagacg agctgaaaaa gacgttggcc aatactgcaa cagttattag 483481 agatggccaa ttgatcgaaa ttccggctaa tgaggtagtt cctggtgaga ttttgcaatt 483541 ggaaagtggc acaattgctc ccgcagatgg tcgtattgtc actgaagact gttttttgca 483601 gatcgatcaa tcggccatca ctggtgaatc cttagccgct gaaaagcatt acggtgatga 483661 ggtgttctcc tcatccactg tgaaaaccgg cgaggctttt atggttgtta ctgccactgg 483721 tgacaatacc ttcgtcggta gggctgccgc cttagtgggg caggcttccg gtgtagaggg 483781 ccatttcact gaagtattga atggaattgg tattatctta cttgttctag ttatcgctac 483841 tttgttgttg gtctggaccg catgtttcta tagaacggtc ggtattgtaa gcattttgag 483901 atatactttg ggtataacca tcattggtgt cccagtcggt ttgccagcag ttgttaccac 483961 gaccatggct gtcggtgcag cttacttggc taagaagcaa gccattgttc aaaagttatc 484021 tgctattgaa tcccttgctg gtgttgagat tttatgttct gacaagactg gtactttaac 484081 caaaaacaag ttatctttac acgaacccta cactgtcgaa ggcgtttctc cggacgactt 484141 gatgttgacc gcttgtttag ctgcctctag aaagaagaaa ggtttggatg ctattgataa 484201 ggcttttttg aagtcattga ttgagtatcc aaaagctaaa gacgccctga ccaagtacaa 484261 agttttggaa ttccatccgt tcgaccctgt ctcaaaaaag gttaccgctg ttgtagaatc 484321 cccagaaggt gaaagaattg tttgtgtcaa gggagcccca ttgtttgtct tgaagactgt 484381 tgaagaagat cacccaattc cggaagatgt gcatgaaaac tacgaaaata aggttgctga 484441 actagcttct agaggtttcc gtgctttagg tgttgctaga aagagagggg aaggtcactg 484501 ggaaatcttg ggtgttatgc catgtatgga cccccctaga gatgacaccg ctcaaacaat 484561 caatgaggcc agaaaccttg gtttgagaat caagatgtta accggtgacg ctgttggtat 484621 cgcgaaagaa acgtgtaggc aattaggact tggtacaaac atttataacg cagaaaggtt 484681 aggtctggga ggtggaggtg atatgcctgg ttcagagttg gctgattttg ttgaaaatgc 484741 cgatggtttc gcagaagttt tcccacagca taaatacaga gtcgttgaaa tcttgcaaaa 484801 cagaggttac ttggttgcta tgactggtga tggtgttaac gatgccccat ctttgaagaa 484861 ggctgatact ggtattgctg tcgaaggtgc taccgatgct gccagatcag ccgctgatat 484921 tgttttcttg gcccctggtc tctctgctat tattgatgcc ttaaagactt ctagacagat 484981 tttccacaga atgtactcct atgttgttta tcgtattgcc ctatccttac atttggagat 485041 tttcctgggt ttatggattg ctattttaaa caactctttg gatatcaatt tgatcgtttt 485101 tattgctatt ttcgcagacg ttgccacttt aactattgct tatgacaatg ctccttatgc 485161 tcctgaacct gtgaaatgga acctaccaag attatggggt atgtctatta ttttgggcat 485221 agttttagct ataggttctt ggattacttt aaccaccatg ttcttgccta atggtggtat 485281 tatccaaaat tttggtgcca tgaatggtgt catgttcctg cagatttcac taactgaaaa 485341 ttggttaatt tttgtcacta gagctgctgg cccattctgg tcttccattc catcgtggca 485401 gttagccggt gccgttttcg ccgttgatat tattgctacc atgtttacct tatttggctg 485461 gtggtctgaa aactggactg atattgtgtc agtcgttcgt gtctggattt ggtccattgg 485521 tattttttgt gtattgggag gattttacta tattatgtcc acgtctcaag cctttgatag 485581 gttgatgaat ggtaagtcat taaaggaaaa gaagtctaca agaagtgtcg aagatttcat 485641 ggctgctatg caaagagttt ctactcaaca cgaaaaaagc agttagtaat tttaaacatc 485701 atccatctga ttttttttct tattgatctc ctttttgtta ttcctcattt tcatttcaat 485761 ttgtcgatac caaggaagcc aagacgttat aaaagaacac ggtcaacaaa aatcaaatta 485821 atgcctcttc aattgtgctc tgtttgatac cttcgatatg atgttacagt tttaaagttt 485881 acacacaagt ttttagacta agtggcatca tatctgtcaa ttttatcaca cacacacaca 485941 cacacacaca caaacaaaca tatccacata tcagaagtag gccgatcttt tgcttgattg 486001 gatgcaaatt catatggaaa atttttttca tattatttcg tgttcttttg actattttcc 486061 tctccaaaaa ggaagaatca ttccaataac aacacacgaa ttcccatcca acatggtgaa 486121 atgactaaat attttttttt tcgaaacatt aaatcaatct aattcttaat ttttaataaa 486181 catataatgc acacttattt acatacaagc acattgcacg tattatatca gtttcttctt 486241 ttatgttgat atatttttct aataatgtta ttatcatgta gtcgtgtatg tgcgcctctc 486301 ccgcgagaag tccaacacca taagaaatca aatgtcaaga gaaataaaga attgtttccc 486361 atcatagata agactatatc agaaaagtgc tcatcaaagc taaatctatt atgagatgtc 486421 ttaggcataa caaaaaaggg agagcggtgc aagataaaca taccgtcgga taaaaagtac 486481 tgtcattatc atcagtggca agatgcaagg tacacacggg caccaagaga taatgcgcaa 486541 aataaaccgg gttttattta catctataca tacagtaacc tctttgaatc atacatatct 486601 gaaaagacgg tagatttaaa atggctattt attgatgagt caatagttcg gactaatggt 486661 aaaaagaaga gacaatgggt agacagagac tttattctat gtaagatagg aatgaccact 486721 cgaaaaacag tagattcaag acttttagaa tggcaaacca catgcaagca tccagtgata 486781 aacttgactc cagagaaagt cgataaatta taccacttga aattgaaaag tgaaagcaaa 486841 aatatcagtt caaacaggct attgcccatt tcattatcaa gcttacaaaa aaaaatggag 486901 aaacttttca tcaaagataa aagtcactca cacaagcctt cccttccaga tcctaaggtg 486961 ccaaccctac gcacttataa agatggtgga tttttcatta gcggaaaagg ttcaatgaaa 487021 ctaccagata tcgaaagcgc tattcataaa tttttatgga agaaatacgg gaaaggattg 487081 gtttactgtt atgggtgtga tccaactgga aaaaagaggc atacagagtg gttcaatgtg 487141 cctgtattgg agctaccatc agtactaaga cttattgatt cttattgcct tggaggagaa 487201 tctcgttaga cttaaaaaaa attttttggc ctattctggc cggtttattc aaattattta 487261 tcatcataaa aattgtagtg ttacctttct tttccttgaa ttatttatag aaatatatgt 487321 gcttagcaat tttatcactg ttacttcgat ttgtagtacc cttaagtaaa agagcttttg 487381 aaaccagtta tcaaaagaat atcaccaatt gatcttttgc tttcgagaat tgtatcacca 487441 tatcttccct caagtagaca gtggacgaga tgtttcgaga tactcgggga aagtctcttc 487501 caatgtgctt cactttcaaa actgggtaaa tatgcaatca gcgtttttac attcaaatta 487561 ctatctttca atttaagctc tgaggttatt ccatcgtgga aagagtttat accacatttc 487621 gatgtaataa aatgtgttcc tgatttgcac ggttttaacg tcaataccga tgatatgttg 487681 acaatataga acccctttgc tttttcttga gcttcagctt gaacctttgg aaaaatgtta 487741 ctcaagcaga acttagttat caatattaca ctttgtaaat tatacctcac gattttctcg 487801 aattcattta aagactcttc atcaagtctc aaaaatttgt cttctttgag aagagtcgat 487861 tcgattccct cctgcatgtt gttaatgagc actgtaggaa ttatttctaa attttgaagg 487921 taaagcatgg attcctcaag acattttatg tcactgaaat ctttgcaaga aataaaagta 487981 tacagttttt cacttctcct tgcgtttttt ccattaatac tgtctatagt gtcaatattt 488041 ataacctttg tatgataatc ttctataaat gtctcgcaga gctcgatgcc taactcattt 488101 gaagaaccgc caataattaa tactgtatcg tggctaggat ggaacttttt acctaaaccg 488161 acatattgat aaaaacttac gaggactttg taaattgttt tcttcatgtc agatttttgg 488221 gctctattac tagtggacct gtgcttcgga catacgcagt ttttctgtgg tttctttata 488281 cgtcacaaat ctgtattatt attgagtcac taattcaaat gcgtgtgaca atatagcgac 488341 ggggccgtgc aaaaataaga gatactgcac ttgcgcggct gatagagatt tctttctttc 488401 tacgctggga tagttttctt agaaggtttt agctattcta attaaaatgt tgttcccacc 488461 agtatttatt ggcaccttgg acaattttaa aaatcactgc taaaacggtg ctatgacacg 488521 attttctggt actaaaacgt gttttatgaa attaacagta tatacaaaaa gtaaaaggta 488581 tggatagtta aatatgtgta aagctataat acaaagaaat aacacaagat agttgagttt 488641 atttggtcaa actaaaaaga ggaaataatt atagtgaata attccagatt ttgttaaaca 488701 ccaattcaaa caaactgaaa acagggagaa accaacccaa aaaataaaat agattcagtg 488761 ataacccaat tctaccgcaa aaaaaaacta aaaaaataaa taatagaaaa ttaacagata 488821 caaaaacgaa aaaacaaact gtttacaaaa catttacatg cgtgttcatt aagctgtcga 488881 aggatattat ttctttgatt tatttttttt tttgaatagg ccaaatctct tcttcttacc 488941 accatttttc tcctcattgt caccattatc ggtactaggc gaagccatat tcgccatttg 489001 acttgatgag gacaaggttg gagtgcttgg ggctgaaaca gaggttgtag gagggggtgc 489061 aatatttttg ggatcgttta tatccacagt gctacttgta ttgttgtttg tatttgtaaa 489121 ttgcattgcg ttatgaacta ccgagttggt ggaaatatca gggttgctac tactgttatt 489181 aactttgttg ttattatttg taacttctat catggtactg gagctaaatt gcctttgtgt 489241 gggaacgtga ttgtttaaac taggagcagg gacttggtta aaagtattgt ttgggttggt 489301 ggcatgtggc atattcagtt tgtttttcga ttgttgtgat ctcaatctat tctggtttac 489361 gatgctatgc gttggcatgg aatttaagcg agtttgactt gaattgttcg gtggtctgcc 489421 aaaatcactc atatttatac tggaaggatt accaatatta ggcatattac tatttctatt 489481 cttcctactt gtgggcttga tagagtgtga gtgaaaaggt tgtacttgta ccgattgttg 489541 tggctgctgt aggggtaagg aaggaggttg ttgcgggtca tatgcagcga tacttgaaga 489601 aattgggtct acaaaatttc cggcggatgc aggttgagac atagcgccat tggtgccatg 489661 cattcctctg ctgttagaac gaacgtttgc agactgctgt aattgaggga aggaaggctt 489721 tcttggaatt gaattattgc tattattaaa tctttgttgc tgtaatgctc ttttctggaa 489781 ctccagttca cgttcttgta gctctaattc ctttttacgg agttgcaatt cgcgttcttg 489841 tagtaatttg tcattcgtgc cattattctc tccgaaagtt tgtgaatgtg aggataatgg 489901 tgagttcatt tgtggctgag agcttacaac aggtggtgga gatctcactg gagagtctcc 489961 gtagtttaca ctatatagtg ccatatcttc gatgtccctc aaattcggag ttcctgttgc 490021 tttatattca tttgtatcgg attggtttgt tgcttcagtt ggcgttagtg cttcaattga 490081 tgtttgagct tgagattggg cttgagcttg ggcttgggcc tgggctttta gagcgacttg 490141 atgtttctcc tttaactcat tagtttccat ttcatgttgc ttggcctgca taagcaactc 490201 ttgtcttagt ttactaattt gaccttgtaa ggaggtaatt tgagtctgta aagcagattc 490261 atttttttgt gatttttgca agctttgtaa gatttgagtt ttttcatctg acctaataaa 490321 ccatttagat ttgccactat tcaatctttc aaattgggac aaaacagagt ataaaaattc 490381 taagtacgga gttttgatac caaagtcatc ggctaataaa atagtttgta acaacaggat 490441 atcgatgttc aaaggcgttg tttgatgaat gaaatgataa accaatgcag gtggcttatt 490501 ggttgaatga taagaattct tccatagaga taaaagagag ttttcattat catgactact 490561 gtttagtctg gctcccattg tttttgctac agtgatgatt tcagttacca gacctgatat 490621 taaaggtttg gcaatgatct gctggtctag atcacttggg ttttcttgtt caaacatgat 490681 taacaacgga tcaaaacaaa ttctggaaat cgccagcttc cattgttgtg atagaaactc 490741 aattgatgag aaattgcaca aattgatttt tatgttggaa aacaatttag caaacagttt 490801 ttcaaaagtg gttaataatg ttataacgcc tgatgaatat ttctcagtgc tggacttact 490861 ttcgccgagg taaatcgtgt tctcctttgc agtactagga aagtgtttga aatggtttgg 490921 accgatttga cgaatatcca aatcagtcaa aatactgaaa acgtttacat gcggagattc 490981 catcgataat ttgacaaacg gttccaattg gatgaaacca ctgctttcta agaaaatttt 491041 ggtgttcgaa tcgattatgg acgttaactt ggacgctaac gaggataatt cctgtaaaga 491101 tggagcactc atgatgatta tgtcgaagac ggcttcactt gatttggagc tcaaagcttc 491161 agtcaagtgc tcgatagagg tgaaatgatt ttccaattcg aaccggtctt tgccgtagta 491221 ttcagtttca atttcaaatt gacatgattt tgaatcgttg acgtggtaga ggtctatatt 491281 cttggccagt tgaaaccttg aggtgtagaa caagatattc gggttgttcc caatagctaa 491341 aactcgaagt gaggaagacg acataactat aacgtgtgtg agggcgagca aagcaattaa 491401 acgaaattga tcttattggt gagcgtcaga ctgctggagt tgtgtgttat aaaatgaaag 491461 aaaaaaaaaa ggaagtaaaa ccagggaacg aaccgataac tatttctccc ctttctgttt 491521 gttcttggtt ttgcttgctt tgttctgatc aagaccaaaa atagctgggt ggctacgaat 491581 aagaaggcca agattagaag tgtgttactc tcactaattg actgtttaaa aataaataaa 491641 caaacaggtt caaagaaacg agaataaaca aacaacgaac gccaacggaa agaaccgacg 491701 ttgtgtttgc gtttacgttc tgctctctca cttgacacaa cacgaagacc gaaaacagct 491761 tgggaagcat tcaccgatcg ttattcgaga ggtttccagt ttcctttttt ttttttttca 491821 ctcgcggtat aaacgaatga aaaaaaataa aaaattttca tgtttttccg ttccggaaga 491881 caaagcctgt ccgcctttaa ggcggtaaaa gccgtcgtaa aggctgtcgt aagatgagac 491941 taaagtaata gtagtgtatt atagatgatt attatcatta tatatacatg gctacggttt 492001 ttcgctgacg ggctgcgtta tgaagcgtgg tggtagtact ctgcaaacca agggtgatgc 492061 agagcctgct tggcgctcag cctcatatcc ggattaagtt gcaagagtcc gtgtaagaaa 492121 tccatgagat tcccgtctag cggttctttg gtgtgtggtt gcaatacttg acgtaggtct 492181 cttggtggtc gttgctggat atttgggttg tatttgggta actttgttac actgggccat 492241 agggactcat taggagtgcc catgatgtcg aagatcaatt tcagttgttc ttcgtcgttg 492301 gtgccaggaa acaaaggctt acccgttatc atttccgcaa gaatgcaccc acacgaccat 492361 atatcaatgg atgtggagta cgtcctagaa cccattagca catcaggagc acggtaccac 492421 aacgttacga cttcgcttga aaatgtgttg accggaatac cgaaagcacg ggccagaccg 492481 aaatcaccca atttcaactg gcctctcttg ttgattaata ggttttgagg ttttaaatca 492541 cggtggagaa tcttgttttc atggcaaaag gccagccctt gcagtagttg ccactggaag 492601 tatttaacca agtttagttc tagccctctt ggtgtgttgc ccacggtgcg ggaatccatg 492661 tatttcttta aatcgttgtc catgaattca aaaaccaaag tcaacttgtt ctctgtgtga 492721 ataacgtcat aaagtctaac aatgttctca tgtttcaatt ctttcattag ggagatctca 492781 cggatggccg tagagggtgt accttcctct gaatccagtt ttacctcttt cagggcaaca 492841 tatacccctg tggttttgtt cagtcccttg tacactgtgg catacgtacc attgccaagc 492901 ttttctaact gcttaaatct gttcatagag ctcgaggttg attttttctc gtatatatgt 492961 tagtattcat catttctagt tctttacttt ccaatgatac ttgactagaa aactacatac 493021 tgtgaagaag aagacattgg tattgctcaa gtttgcccag tttgccgcgc tatatatccc 493081 ttatctgcaa ttatacgcta tatggtaaaa ctggattccc tttgttatct ttcaattaga 493141 aagctacggg cttacgagtc tacgtgtatg gtgatttgta cggaaaatga actgcacaca 493201 gaggacaagc aaagggtcta ggatagatag aagtagcgca tccggcctgt ctatccctcc 493261 gtgtctatca attcatttaa cgtgtctgga cggactatgg taactacttt ttgcgttttt 493321 gcaccttctt cctgtttttt tggttttagt agtgcactta ttcttcactt ttttgctctg 493381 cattgttaaa aatttcattt tttgcatttt ggaaaacccg atgacattat tctttgaaat 493441 aaaccatatc atttagaaaa tgcgatttcc attacgcaag atagacaacg catttggtcc 493501 gattatattg ctatcttgtg atacttctcc tttctctcaa caatgactgg cgacggtagt 493561 gcacatattt ctaaaaacaa tcaaaatcaa cacaaagatc gcttcaagtt tattgtgaat 493621 gataaaagta ttctaggacc tcaatggtta agcctttacc aaacggatgg gaaagtaaca 493681 ttcgcaaagt cccacttcga gcaagcaatg atgaacgtta ttagagaacc aaatattaac 493741 tctactgtca tattaagagc ggatattttg aaagagatca atcatgctgc agaagctggg 493801 tctgagccaa aatttgacga gtccgtatta aaaaagtttg agatcgataa tggtaatgaa 493861 agcggtgaag aagatgtcaa gaagataaat attgaagatt taaacataag gtcgtgtgaa 493921 acatctgaga gtttaaaatt gtcacccgtt catgaatttg taagaaggat cattcctagg 493981 aatttttaca aagatgctat cataaaccaa acatgtttaa tcctaaatag caaagaccct 494041 aattttcagg agacctcatt gattgtatat acgccgcaca ttaactctga gaaagactgt 494101 ccgttttata ttccaagaac gcaaagtgta ggcattttgt tacaccagtc agttctttct 494161 gtacactaca ttcccttccc cgaggataaa actgccttta cagatgaatc tgagcgtgtt 494221 gtaagaaccg cttataggtt attacaaact gctaacaaac actcaaaggg tgtgatgcag 494281 ggttatgaaa agagggtcaa tcacgatcaa gtggtaaata aagtcaattt tcagaacaca 494341 tacattgttt tgaagaaaaa atactccaag ttcctggtgg agaattgggc agagtctaca 494401 gacccaaaaa aacatgtttt tgaagacata gccattgccg ctttcctgat tgaattatgg 494461 attaaagtgt acggtccaga cttccgttca aaaatgcaat ttagagattt gggatgcggc 494521 aatggtgctc tttgttatat tttactgagt gaaagtatta aaggtctcgg catagatgca 494581 aggaagcgca aatcgtggtc tatctacccg cctgaagtgc aatcatcgtt aaaggagcaa 494641 gttataatac cttctatcct tttaagaccc catcctgctt tgaaaagaca agtacctcat 494701 ttggaacaca atgggagatt tttcccagtc aaggtgacgc acgaagtgat tgcccccgca 494761 accgtcgtgt attcaagtga ggacttacta aaatctccgc aggtcaatac agcagagttc 494821 ccaccagata cttttattat aggtaaccac tcagatgagt tgacttgctg gatcccatta 494881 ctaggtcatc cttatatggt tataccttgt tgctctcata atttttctgg ccagagagtt 494941 cgttttaacg taaggaaacg ttcgcctagg tcaaatgaaa tcaaaaacca gaataacagt 495001 aagagcacct actctggttt ggttgatcac gttgaatata tttcatctcg tgtaggctgg 495061 aaagtagaga aagagatgtt aaggatacca agcacaagaa atgcagccat cataggtgta 495121 gaaaatgcaa ccttaaagca ttttccaacg caagcagtgt acgatatgat ttgggaagac 495181 ggtggagctg aagggtggat tcagaacaca atgtccttat tgaaaagaaa cccaagaaac 495241 cattaaatag atgtatcatc tattatttgt atgtgcgttc atttatagac taattagaat 495301 atcatacgta catataagac tatacaattt atctaatttt ttcattttta cttaaaaatt 495361 gatggtccat cgtaaacagc gttaataatt tcttcgcccg atgcatagac aatgagaagc 495421 caaaatgcag aaacttgata ctttcaaaga aagaggttca actatgaaaa gaaagaagat 495481 ttaagtgccg atagagtata ctagcatggc acttgtcaaa tacagcacag ttttttttcc 495541 actccgatca ttgcgactgt ttgtgtccat caagaaagca tattaccaca gcgagccgca 495601 tagcatcgat ctatttcatg ataaggattg gattgtgaaa agacctaaat tcctaaattt 495661 acccaaaaat gaacattcaa aattagatat attccagttt aattttaaca agtccgaaag 495721 caataatgtg tatttacagg attcatcatt taaagataac cttgataaag cgatgcaatt 495781 tatctataac gataaattgt catccttgga tgccaagcaa gtaccaataa agaatcttgc 495841 ttggttgaaa ttaagagatt acatatatca acaactaaaa gatccgaaac tgcaagccaa 495901 aacctatgta ccttcggtaa gtgagatcat acatccttca tctcctggca atttgatttc 495961 gttgctgata aattgcaata aaatcagcaa tttagtctgg aaatctgttc tcaaatatag 496021 cctgagtaac aatataacta cattggataa atttatccac gtcctgcaac agaccttcga 496081 ccatgtgtac gagcaggaga tactacccat gatgacgaat acagatgata cagatggcgc 496141 tcacaacgtt gacataacaa atccagcaga gtggtttccg gaggcaagaa agattagaag 496201 acatataatc atgcacattg ggcccacgaa ttcaggcaaa acttatagag cgttacagaa 496261 attgaaatcc gtggaccgtg ggtactacgc agggccgtta agactgctag caagggaagt 496321 gtacgataga tttcatgcag aaaagataag atgcaattta ctgactggag aggaagttat 496381 tcgtgatttg gatgatagag gaaattcagc agggctgaca tcaggcacag tagaaatggt 496441 gccaataaat caaaaatttg acgttgttgt tcttgatgaa attcaaatga tgtctgatgg 496501 ggatcgtggc tgggcttgga cgaacgcgct tttaggtgtc gtttccaagg aggtccatct 496561 ttgtggtgaa aagagtgttc tacctttggt taagagcatt gttaaaatga ctggcgataa 496621 attaacgatt aatgaatatg agaggttagg aaagttaagt gttgaagaaa aacctatcaa 496681 agatggcatc aaaggtttgc gcaaaggaga ttgcgtcgtt gcgttttcaa agaagaaaat 496741 attggatctc aagctaaaga tagagaaaga caccaatttg aaagttgctg taatttatgg 496801 ctctttgccg cctgaaacac gtgttcaaca agccgcccta ttcaacaatg gagagtatga 496861 cataatggta gcatcagacg ctattggtat gggtttaaac ctgtctattg acagagttgt 496921 attcacgaca aatatgaaat ataatggtga agaactaatg gaaatgactt cttctcaaat 496981 caaacaaata ggtggtcgtg cgggaaggtt caaatctaga tctgcctccg ggggtgttcc 497041 tcagggtttt atcaccagtt tcgaatcaaa agttttgaaa agtgtaagaa aagctattga 497101 agcacctgtg gagtatttaa aaactgcggt tacatggcct acagatgaaa tatgtgctca 497161 actaatgaca caattcccac caggaacgcc gaccagtgtc ctgctgcaga ctatttcaga 497221 tgagctagag aaaagttctg acaacctgtt cacgttatct gatttaaaga gcaaactgaa 497281 agttattggc ttattcgagc acatggaaga tatcccattt ttcgacaagc tgaaactaag 497341 caatgcgccc gtgaaggaca tgcctatggt cacaaaggcg ttcaccaaat tttgcgaaac 497401 aatagcaaaa aggcatacaa gaggcctact gtcataccga ttacctttta acctactgga 497461 ctacaattgc ataccgaatg agagttattc attagaggtt tatgagtcat tgtacaacat 497521 cattactcta tacttctggc tcagcaacag gtacccaaac tacttcattg acatggaatc 497581 tgctaaagat ttgaagtatt tctgtgagat gattattttc gagaaacttg atcgattaaa 497641 gaagaatcct tacgcacata agccctttgg ttctacaaga ggtcacctct catcttcgag 497701 aagaagattg cgtacataat ctacgatata tcctgtaaat agaaacagct acactgcttg 497761 aaagccttaa catgatacat ttctggtatg atgccattgt tgtgccctgc cgggtttatc 497821 gtttcctaac aggcacgtca cttataacga ggtgcctgtc gtttaccgcc caagccggtt 497881 ttttcgctgg agagtacggt actactagcc caccacacgt tcgtggccag gttgataggc 497941 caccgttgag caaagggcag taaaatatat aaaagaggaa caagcgcttc cattaagagc 498001 actgctaagc ctactcgttt tctagttctc tgaaaaaagg tagcctaaaa caagcgccat 498061 atcatatata tttatacaga ttagacgtac tcaaaatgtc tcagaacgtt tacattgtat 498121 cgactgccag aaccccaatt ggttcattcc agggttctct atcctccaag acagcagtgg 498181 aattgggtgc tgttgcttta aaaggcgcct tggctaaggt tccagaattg gatgcatcca 498241 aggattttga cgaaattatt tttggtaacg ttctttctgc caatttgggc caagctccgg 498301 ccagacaagt tgctttggct gccggtttga gtaatcatat cgttgcaagc acagttaaca 498361 aggtctgtgc atccgctatg aaggcaatca ttttgggtgc tcaatccatc aaatgtggta 498421 atgctgatgt tgtcgtagct ggtggttgtg aatctatgac taacgcacca tactacatgc 498481 cagcagcccg tgcgggtgcc aaatttggcc aaactgttct tgttgatggt gtcgaaagag 498541 atgggttgaa cgatgcgtac gatggtctag ccatgggtgt acacgcagaa aagtgtgccc 498601 gtgattggga tattactaga gaacaacaag acaattttgc catcgaatcc taccaaaaat 498661 ctcaaaaatc tcaaaaggaa ggtaaattcg acaatgaaat tgtacctgtt accattaagg 498721 gatttagagg taagcctgat actcaagtca cgaaggacga ggaacctgct agattacacg 498781 ttgaaaaatt gagatctgca aggactgttt tccaaaaaga aaacggtact gttactgccg 498841 ctaacgcttc tccaatcaac gatggtgctg cagccgtcat cttggtttcc gaaaaagttt 498901 tgaaggaaaa gaatttgaag cctttggcta ttatcaaagg ttggggtgag gccgctcatc 498961 aaccagctga ttttacatgg gctccatctc ttgcagttcc aaaggctttg aaacatgctg 499021 gcatcgaaga catcaattct gttgattact ttgaattcaa tgaagccttt tcggttgtcg 499081 gtttggtgaa cactaagatt ttgaagctag acccatctaa ggttaatgta tatggtggtg 499141 ctgttgctct aggtcaccca ttgggttgtt ctggtgctag agtggttgtt acactgctat 499201 ccatcttaca gcaagaagga ggtaagatcg gtgttgccgc catttgtaat ggtggtggtg 499261 gtgcttcctc tattgtcatt gaaaagatat gattacgttc tgcgattttc tcatgatctt 499321 tttcataaaa tacataaata tataaatggc tttatgtata acaggcataa tttaaagttt 499381 tatttgcgat tcatcgtttt tcaggtactc aaacgctgag gtgtgccttt tgacttactt 499441 ttccgccttg gcaagctggc cgggtgatac ttgcacaagt tccactaatt actgacattt 499501 gtggtattaa ctcgtttgac tgctctacaa ttgtaggatg ttaatcaatg tcttggctgc 499561 cttcattctc ttcaggctct attaatttta accgttataa gttccttttc tcccttggaa 499621 gcaaacatca actgccttaa aatctggtgg cgaggaaaga ggaaatggca tgtactaatg 499681 atggtcctaa taaatatccc gaaattgtga gtgttaagca cctgttccaa cattcgggat 499741 ccaagcatga atttagtgct ggtaaacgat tttcaaaatc cattggtaaa atattcaaac 499801 gaaactctgc tttgaaaact tctagaactg aaacggcaaa tcataaaatg gaattgaaaa 499861 aaagagaggg tgttacctta ttgccacctg tcccagaatc attattacat aaactcaatt 499921 cttggttgga aactttttct tccaccaaga acatgaaaat cgaagaaaac aaaattgtta 499981 ttaatgaaaa agagattcgg gattcagtct cttactaccc tgataagaat ggaggaagtg 500041 ctgtattttg ttacttgccc gaccttgtgc tatattataa gccgcctata aaagtcacag 500101 gcaagcaatg tccaataaag agaagtcctt gggaatcgat ggaaatccaa tatcaaaagt 500161 ttatgtaccc cttagaaagg ttggaaagac agtttgagga agttccattt aggccctggt 500221 attttgcaat gcgattaaag gaactttaca gatgctgtga aaggtctttt actaacgcgg 500281 caaatagagg aaaggcaagg ttattgcggg ggaagcaaag gacgaaaaaa tcgtatcata 500341 agactgtcaa cctggtatca gcgaagattt ccacccattc aaatgcgccg tcgccgggct 500401 gagaaacaaa aaaagtgact aagttctgtc attctatcat tattgtaatt agttatgtag 500461 gacatatata tccatagtga tctccttttg atcaaagaag acactgaaaa gtcgtaagtt 500521 cgtaaaaaaa gtatgaaaat cgttccagcc attgcttata gccatcctag taggatacta 500581 gaaaaaaaac aaacctcaaa gataaaaaga aaaggtgaag ctattaccga attagaacat 500641 aagataatac agtgagtata aaggtgagac ctgctcaata atctggtaac catttctcgt 500701 ttggaccgtc tgttaaagta gaaaaattca tttgtaagca taatagccta tttcttaatg 500761 tatcttgttg gaatttgcaa tctttggaag cactaacgtc atcgatatca gattggtaag 500821 gtgtactgtc cattgaggaa gttaaaaagg tactattatt gtggttgtta gtgtattcat 500881 acttttccat acttccgtca ctattatacg ttgatggaat atcactctcc ggttcagcat 500941 cttcctcttc ttgctgctgt tgtgcttgtt cctggttttg tatttgttct tgtttttgtt 501001 cctgttcttg ttcttggact tgctgttgtt gttgttgctg ttgttgttgt tgttcttggt 501061 ctgcagaaaa atgtgataaa tcgctcaaaa ataggttttc attccttata atatgcgtca 501121 tgtaaacttc gctcgatagg attggaactt gagacaaggg cccttccctg gtgaaagaag 501181 taagagagga aacttcggac atcaaagttt tcatgtctat tcttgtgtat ggatttagtt 501241 gtagaatttt cgtcaacact gtgaacagct catctgatat aggaaggatt ttcttcagga 501301 cattattatc gttagcaaaa tgttgaaatg tgttatcctc cttctggtga gcttttaacc 501361 atgggtttct tatgcaagtt aaattaatta ggatgatgcc tagagaccat atatctcctg 501421 tatccgtagg gaggctcgaa cagcattcgt cgacgtgtat gccgttggtg gtggtattca 501481 aacaatacaa tattctttct ggagccatat aatatgaact gccaacgcac acatttggag 501541 ctagatattt agatttagtg gaaagcccga aatcgcaaag ataagcgttg tcattgcgat 501601 ccagtaggac attttcaggt ttgatatcac aatgatatat accgagacga tgacagtgat 501661 ctaatgcgga gcaaagctgc agaaaaactt tcttaatcaa aataccatga tttacaaaat 501721 gcttatcgtc aactatcgag gtgaaaaggt ccctgtcgta ataatccatc actataaaag 501781 tggcaataga agattctaaa acttggtgaa tcttcacgat attgccgtga gactgcactc 501841 ttagttggaa ggcaatctcc ctgtagtgtg gtagcctatt tagttcattc tcagtcaact 501901 gtaatatcga gtctagatca acggaaggta agaacaattt tttttggaaa cttttgaaaa 501961 aatgatacag ttgcgtttgc agaagagtgg ttcgcgccac ttgagagttg ttgttcaaac 502021 cgttcttatt ataaaactca tccatcgagg aggatttgaa gaccgttttc actgcatatt 502081 cacggctcgt cagtatatcc accacatgga acactagtcc atacgcaccc gaccctattt 502141 gagccgttat tctgaaattg ttcagcaagc agtctgacag catttgtaca caaaatttct 502201 tgtctgtgtt cttatttgat gttttctttt aaagagtttt gtttccgcta gggcgattta 502261 agtcaataag taaatttaac aatttactaa atatattttg tataatatat aagaatatac 502321 gccttaagaa tgtcctctca tgcgaaaaag gtagcaagag cataaaaagg aaaaagaaaa 502381 cgctatagtc atttgtaggc tcttgtcttt cttcgtcttc gtcccgtgag tgcggactca 502441 gaaaacaccg caatgatgtg ggtccggaat atctattgca cagttttagt agggtcaccg 502501 atatcgttaa ggtttgtggt aggaacagaa ggtactgccg gccctgtata ctgccctttt 502561 gttccgacca tttctttttt gcatttgtcc caagattctc tctccccaca aaatctgctc 502621 aagtatctgt ccaacgcgct ttcttcggct gatagataag ttccgatttc gtgggaagca 502681 aaaaaaaaaa aaaaaagaaa aaaagagtct gtccgagaaa tgtcccggaa aacgtgggtg 502741 tgcggtgagg agattgtact tccatcccac attcctcgtg tttgattggc tgcaagccac 502801 ttgatgccta gaaaagaaac accgcgtggt gcatctatgt ccatatcacg cgcgctaaaa 502861 cagcatgtag agagcgcgag ggcggcgtac tgcaccattc taataggaaa tccgggatga 502921 atgccctctc cggaaatacc tccactaagc ctcaatggaa agttgttccg ctcacgcgaa 502981 caggtttttc cggggagtcg agaactacag tgacgtaaat acgacgacat cgctagagcc 503041 agcagaagcc tccatacatt cagactaatt agttgacggg cttgagccaa ctagacatat 503101 tatgtaggca catatgctcc aaccaataca tatgtgtaca tagagtacag ctcttcccag 503161 cgcatccgct atcgtcctct tgacaggtcc ggctatttat tatccgcggc atccgcggcc 503221 cagcgcacaa taatagatta ctttgcaatg caagcggtct tggctgtttg ctctgagggt 503281 ccatcttcgt ttatttcttt atttactaaa ttaattatga tactgcactc aggacgggcc 503341 aagaaagcat gtagcgtgaa gagaaactaa ttattaagaa aaaagaaaaa aaaaaaaaaa 503401 aaaaaaaaga aaaggaaaaa ggaaaaagat aaaccaatca tacaatcttt acagaaaggg 503461 agtactgaga agaaggccaa aatactgcag agcatacata ctaccgagtg gatggaatgt 503521 ctttttcatc tatcttatca caggatatca cagatgacat tacaccacca gcgtattccg 503581 ccaccttggg gtcgagagaa cagattgttt tcagagctta ccaaaatgaa ccttggttgg 503641 ctggtactgc ttcgaatctt atcttagata aaaaacttgt tattgtagac agagaactgt 503701 tgttccaggt gttgatggta gagaatatca ccaaatccaa gctaacacag atcgatgata 503761 taaaaaccaa gctggatccg aaaaaacaga aagtggatag actacgatca ggcgcgcaag 503821 gaaatggcgc taagaagtac gaggtcatca ctcaagtgga catggaagat gacgggaatg 503881 tggcggataa caactgcgcc aaggaaaata atagcaacaa taatagcagt gccgccaaga 503941 ataaagcagt gtttaaattg acactacaaa gtaagtcggg cgacgttttt tttgctatca 504001 actcgactcc aatatcttgg agctcttgca tgctgggttc taaaattgtg atactgccgg 504061 gaactgtgtt caataggggc gttttcatat tgaaggactc acaagtcatt tttctcggcg 504121 gcattaatag agtttggaat gaaaatagag atcagaaatt ttgtgattat ttggaatcta 504181 aattacaacg tgacaaacaa cttgtaaatg gcggctccaa gaaaaggaaa gccaatgatt 504241 agcatatgcc tcttcttctt agaagggcgt tctgcccgtt atgtatacgt taaatattac 504301 attattttcg catttttgta tttatattca gtgaaatatt aggcttggtc gagtaacatt 504361 tcccatagct cgtcggtttc tttgaagtcg tgatgaacaa ttgagacaag acagtagtct 504421 ttatgcacta gtcttagaag aatattggct ggggtgttcc ttggaaataa cttggcccac 504481 tcggaccaga tactaaacgc ttcatctctc catgccttga atgactcttc ttcaatgatt 504541 gtagtctgtt tgaccggact gttgggaaaa acaccccatg ttacaacgct agagctgtgc 504601 gggtctaggt tcgtttcaaa tgaaccagat gaatcgcccg cgtaataact gaatttccga 504661 cgcccgtaat ggtctagctt gggtttcaaa gttgtttccc attgctgtct atgaataaac 504721 atttctacga atgccttctg atacaacctc cctttcgcgg gcccccagcc gaatatttta 504781 tcactactca atgtagcatt tgtggcaggt tgcgatgcca aagtcaaata tccgcgatag 504841 tttagttgga ttagttcttc ttgtattaac gccgtttcag ctgataaacc caggtcagac 504901 cagggaatcg catccgttga accttccaaa tattttataa aaatatcttt taaatcgcca 504961 attgtctttg gtatacccca tagttcaagc gctttgcttt tgcttacctt gatggatggc 505021 ccataaccgt ctatttcacc atatgcggga gacctggagt caccaaatct accattgggg 505081 aactcatccc aagtggcatc acgacccaaa gttccgtgac ctttagaaat agatattaaa 505141 gcctttttag atggcatgga accattctca ttattatagc gtaagccttt ttcagtgacg 505201 atagccctat tgaaaatcaa cttggccgaa tcaagacttg aatgccttct ccttttccgg 505261 tttgctacag tttcttcatt cgaatcatcc aacacaatat ccccgtcagc atcttctatt 505321 ggcacatttt ctatgcttcc tatttcgcca ctggtttcat cttctccctc ttcttcgcta 505381 gattcattta cgatatggga taagacggga gattgcgaga caatttgagc aatagccttt 505441 tccaaattta atgtatagaa atgaaaccct ttaattctac cagatgttct ttgatatatt 505501 tcctgaatca attcgataag aatgtccaca ccaatggact tcacggcatt atcatccgat 505561 tggatttctg gggggaacct actcagtatt gcaggtggaa tagatgcatg tgataacttt 505621 gctgctctgt ggaaaagcag ataggagtta ataggcatca acccagggaa aaggggcaaa 505681 tcttgcgaaa tccgttcccg aaatagcatt tcaaaagtta agaatttttc aacgtcgtaa 505741 aacagttgtg ttatcacaaa atcggcccca gcttcaactt tttcttttaa atataccaaa 505801 tccttcaatg ggtcttgctc gtgaccttct gcttcacctt cacaatgacc ttctggatat 505861 gctgcaacac cgacgcagaa cttgtctccg tagctttgct tgatataacg aactaaatca 505921 accgcatatt taaaaggtga ttcgttcgat tgagaatcta gccaatcttc cccaataggt 505981 gggtcacctc gaagagccaa aatattcctg attcctgcat tataacatct atccagcgca 506041 tcatcaatga tggctttttc tgtgtttgta caggtcaaat gcatacaaac tggtatattt 506101 agtgtctgct gtgccaagga agctaatgtc agagtctttt ccgcagtagt accacctgct 506161 ccccaagtaa ccgtgataaa cagtggatct aaagcagtca tacgatgcat acgttccatc 506221 aaatttctcg tccctaattc agtctttgga gggaagaatt ctaacgatat aaaaggggaa 506281 gccctcgcat gatataaatc tctgatggac atgtttaaaa aatgtaatca acctgtcccg 506341 tccaacacgc ttcaaaaaat gtacgaactt gaaacaaaat agatgatgtg agagcttaag 506401 tccctcttcc aatgtaacca acaacctgaa gtgttctctg tttgccttta ttttgcgact 506461 tttcttcatc attgaagtta gaaaaagctt tactcgctta tctcctggag taagctatag 506521 ccacagtcaa tatcgcgtct aatgaaaaaa aaaagtcggg acgagtaaac ttttgtctgc 506581 gtggcgcata ggagaggaga gagcacaggt gtactggagg gttcaggacg ttggtagagc 506641 atttgctaaa tgtgtaaaaa taatattgca ctatcctgtt gaaaatatct ttccagatgt 506701 ctcagttatt ttatcagggc gactctgatg atgagctcca ggaggaactt acgaggcaga 506761 caactcaagc atctcaaagt tctaaaatta aaaatgaaga tgaacccgac gactccaatc 506821 atcttaatga ggtggaaaat gaagatagca aagttttaga tgacgatgca gtgttatacc 506881 ctcttatacc taatgagcca gatgacatag aaacgtctaa gcccaatatt aacgatatta 506941 ggccagttga tattcaattg actttaccat tgccgtttca gcaaaaagtg gtagagaatt 507001 cattaattac tgaagatgca ttaatcataa tggggaaagg actaggattg cttgatattg 507061 tggccaattt attgcatgtt ttagctacac caacatccat taacggacaa ctaaagcgag 507121 cgctcgtcct agtgttgaat gcaaaaccta tagataatgt aagaatcaag gaggccttag 507181 aagagctgtc gtggttctct aatactggga aggacgacga cgatactgct gtcgagagcg 507241 atgatgaact ttttgaaagg ccttttaacg tagttaccgc ggactcgctg agcattgaaa 507301 agagaagaaa gctatatatt tctggcggaa tcttgagcat tacttctaga attctcattg 507361 tggatctctt atccggcatt gttcacccaa atagggttac gggtatgctg gtattgaatg 507421 cagactcact tcgacataat tcgaatgaat cgtttatatt agagatttac aggtctaaaa 507481 atacttgggg ttttattaaa gccttttctg aagcaccaga gacgtttgtc atggaatttt 507541 cacccctcag gacgaaaatg aaagaattac ggctaaagaa cgttttgcta tggccgaggt 507601 tcagggtaga ggtctcttcc tgtttgaatg ccactaataa gacgtcacac aataaagtca 507661 ttgaagtcaa ggtctcctta acaaattcca tgtctcagat acagtttggc ttgatggaat 507721 gtttgaaaaa atgtattgct gagttaagca gaaaaaatcc tgaactagct ctggactggt 507781 ggaatatgga aaatgtcctg gatataaact ttatcaggtc aattgactcg gtgatggtgc 507841 cgaactggca ccgaatttct tatgaatcaa aacaactggt taaggatata agattcctac 507901 gccacctttt aaagatgctc gtaacttcag acgcagttga cttttttgga gagattcaat 507961 taagtttgga tgccaataaa ccgtcagtat cccgaaaata cagcgaatca ccgtggctat 508021 tggtcgatga ggcacaatta gtcatatcgt atgcgaagaa aagaatattt tacaaaaatg 508081 aatatacttt agaagaaaat ccaaaatggg aacaacttat tcatatatta catgatattt 508141 cacatgagag aatgaccaat caccttcagg ggcctacttt agttgcctgt tccgacaacc 508201 ttacatgttt agaactagca aaggtcttga atgcctcaaa caaaaaaaga ggagtacgtc 508261 aagtgcttct gaataaattg aaatggtaca gaaaacagag ggaggaaacg aaaaaattgg 508321 tcaaagaagt gcaaagtcag gacacttttc cagagaatgc aacattaaat gtaagctcga 508381 cattttccaa agaacaagtg accacgaaaa gaagaaggac aagaggtgct tcacaagttg 508441 cggccgttga aaagctaagg aatgcaggta ccaatgtaga tatggaggtg gtttttgagg 508501 atcataagtt atctgaagaa attaagaagg gaagcggtga tgatttggat gacggtcagg 508561 aagaaaatgc cgcaaacgat tcaaagattt ttgaaataca agaacaggaa aatgaaatcc 508621 ttatcgatga tggggatgct gaatttgaca acggagaatt agagtatgtg ggcgaccttc 508681 cgcagcacat cacaacccat ttcaataagg atttatgggc agaacattgc aacgagtatg 508741 aatatgttga tcgtcaggac gaaattttaa tctctacgtt taaaagtctc aatgacaatt 508801 gctcattgca ggagatgatg ccctcttaca ttataatgtt tgaaccagat atatcgttta 508861 tcaggcagat tgaagtttat aaggccatag tgaaggattt gcaaccaaaa gtatacttca 508921 tgtactacgg tgaaagtatt gaagagcaaa gtcatttgac tgctatcaag agagagaaag 508981 atgctttcac aaagttgatt agagagaatg caaatctgtc ccatcacttt gaaacgaatg 509041 aagatctttc tcactacaaa aatttagctg aaaggaagtt gaagctttca aaattacgaa 509101 aatctaatac cagaaatgcg ggtgggcagc agggattcca taatcttact caggatgtcg 509161 tcattgtgga tacacgtgag tttaatgcct cattaccagg cttactctac cgatatggca 509221 taagggttat tccttgtatg ttgacagtcg gcgattatgt gataactcct gatatttgtc 509281 tcgaaagaaa atcgatttct gacttaattg ggtcattaca gaataacaga ttagccaacc 509341 aatgtaaaaa aatgttaaaa tactatgcat atccgacact attgattgag tttgatgaag 509401 gacagtcgtt ttctttagaa ccttttagtg aacgtagaaa ttataagaat aaagacatat 509461 caactgttca tcctatatca agcaagttat cccaggatga aattcagcta aaactagcca 509521 aattagtatt gcggtttccc actttaaaga ttatatggtc ttcctcaccc ctgcaaactg 509581 taaatataat cctagagttg aaattaggac gtgagcaacc tgaccctagt aatgcagtta 509641 tattgggaac gaataaagtt agatcggatt ttaatagcac tgcaaagggc ctgaaggatg 509701 gtgataacga gtctaaattc aagagactgt tgaatgttcc tggagtgtca aaaattgatt 509761 atttcaatct ccgcaaaaag atcaagagct tcaataagct tcaaaagctt tcatggaatg 509821 agattaatga acttattaat gacgaagatt tgacggatag aatatactac ttcttgagaa 509881 cagaaaaaga agaacaagaa caagagtcaa cagatgaaaa tcttgaatct cctggtaaga 509941 ccactgatga taacgcttta catgatcatc ataatgatgt tcctgaagca cctgtgtaaa 510001 atattgttta atttaacgaa ccctgttaaa acatcagtat aaaatgcgat taactatagt 510061 gaaaataaca atattcattt ggtgacttcg accgtatatg ttataagtta gacatgctct 510121 ttgaatcttt tactttgata ttttattccg catatatatt ctttttttcg cgttcatagt 510181 ttattcactc aaatttttca tatcatccgc aattcatctt ccacttttta gcagtaaaaa 510241 tgaccaaatg aagttcattt atttttgatt ttttaaccgt atttggtgga atctgagcgt 510301 ggcattagtg aatcatttta agccaaatta cccgtgagtt tttcttagaa gcgcacaatc 510361 atattcatta ttaataaatg cttcaaattc atcctcttga ataaggtcca gaaataattt 510421 tgtctctttt ccattaccta tgtgggtaaa aattttcttt tgcgactaag attcaagaga 510481 ccaagtttct tttccacaac gatatataat aaaccaaatg gtacaaagta ggaaacaaca 510541 aataaggaaa gctttttctt aagtagattt gtatatttat ccaagaatga acgatgtgtc 510601 tcgtaaacag taattccttt taaattttat atttcttcta ttttctgaac ttttttactt 510661 aagaaaaaat ttggaaatca ttacctgtag gatggcttag ctctgataat caacctacca 510721 aagtagtttg cagttatgtg cacttttccc ttcatgttaa cattattcgg gccggtctat 510781 tgttaaataa ttaagggtcc attttaggca cggcggattc acagaaaacc acgcagtgct 510841 caacgtcata taccacaaaa tccgttttcg tattaaaagt gaatgtgtca gtaaaaggca 510901 ttctttttag cgttcattat ttcctttaat atgatgtacc aatctgtcca ctgcctatgt 510961 aaacttaaaa gggaggcatt tatgacttga gatttggtta aattaccaat atctcaaggg 511021 taacaatatt tgctatactg gtcatctaga ataaaaatac tgcgttgtag tgctgagtga 511081 tagaactttt aaatcatatt atgttatata acaaagagca gggaacaagc ggcgctagta 511141 gctctggtcg tagaacgaaa ttccacttcg atcgttttgt acaaatggtt ctgttcattg 511201 ccgctaatcc caattattgc tgttcagtag ccagtatccc gaaatctggt gtcacgccag 511261 atttaaaaag agcagatatt cttgaacaga agatcaaaag cttaaatagt gcgctgagtc 511321 caaaattgaa ggaagaaagt cgtcttggtg ggcctttgca taacccctct attctaccag 511381 ccccatcttt ttcatcacta ccaatatcat ccaatggaaa gaaatcttta gcaggatata 511441 gacctaaaag taggaagaaa caaactatac tccccaacgg tcaaccaaaa gagtgcgcca 511501 cttgtggtga cacctggact tctcagtgga gaagtggacc taatggaaat gttgagctat 511561 gtagtcgatg tggcatagca tataggaaaa aaatggagaa aaaaatacga tcgcaacaat 511621 cctccgatga tggtactaaa aattttatat ttaaaaataa atagttaagt agtttgtaaa 511681 gatggtatat tcagcggatt cttcctctat ttttatgttt tttgagatat ttcgagcttt 511741 ctattttttt aaaatgcctg aatttccatc ttcaaaaaaa acataaaaaa ggtactttac 511801 caccaaataa atgataacca caatttactt tacttatcct ccactatcaa gtatcttcct 511861 accaggaaaa atgaatttca aatgattcga aatttacgga ggctcaatat agagatagtg 511921 tgacgatgtt cataagggct ttaccgctta gcacgtatct acagttttca ctcaataata 511981 tattctctag gaatgattgc caatagattg atatccaaga gaaggttcaa ttaaggaatt 512041 tcatttcgtt ctaatctttt gttgaaaata aaaattttta cttatatgtt aaagcttaag 512101 attccacata aggtcgaaga caatcgtcac taatgtgtgg ttctgcctgc tcatctctaa 512161 aatatattac tttttgtaca gacatctaaa ttgagctggt gcttatgcta ttcttatgat 512221 ttattttcaa gtggtttatt gaactttatt ccatatccaa tgatctgaat atttctactt 512281 atgtataata attgtatatt ataaaagaat aactatttta aagcgtcggt taaaatcaaa 512341 tgggcaataa atcttctcat cctaatcgca tctttataat caaaatccaa tggcgcatct 512401 gcacttccat agagagtatt catacaaaca tatattccac agtcgtagcc atttggttgc 512461 tgcggacaat ctaaatgaat caaatcaaag tcttctccta ttgtatgctt actttcctcc 512521 ataacatatt tttgcaagtc agtcagtata gcgaaactca tagcatttgg accattcgat 512581 aatgaatcta cgtaacctat agttttcttt tttaaatcaa ttatgcccaa cgcccagtgg 512641 gattggttca aatttattgg tgtaaagatt ttatcaagtt tatcaatttg tgtcttcttt 512701 ctcttcatcc acctccggac gccttgataa cccctttctg ataaattggt atagaaaaat 512761 gaattaaacg ccactgtatt aggggtagat ttttcaatgt atttcataaa aaactcaatg 512821 atagtgtcat ttagccatct tcgtggtgcc aaggtcttaa aatcacgtac tgttatctct 512881 atattatctc tattcattaa ctgagtattt tctctagatg ccaaagcttt ttgtacttgg 512941 tcatcgtctt tttcatttaa ttcaggaaca agtttcttct tggccaattg ttctttcttt 513001 tttttaagat cttcttgaat cttctttctt tcatttaaaa tttcgttata tcttttgaag 513061 tctttctcaa actctaatat agatctatca aacttcaact tttgatttaa gtaatcctta 513121 tgtttccttt ccaaagaaga tatctttttt tctttaacaa atactaaatc atcatcattt 513181 tcatttcttg tctgtagtct gttcttgttg ttctcaatta aaattgtttt gatcttttca 513241 gttaagtcga ttatagactt ttttaagcca gtgtcttttt ccttatccat atccattaat 513301 tttaactgtc tttctctttc ttcttttaat atttttggaa ctttatattc tccgttgaat 513361 atttgtcgta aatatgttac ttcctcagat tgtgctctcg acaccagttt agtattgtta 513421 atgttctgtt ttgcaacttt tttctttcta ataaaggctg tcccatactg tcgcctgtcg 513481 tagctatttt tctgatcaga agtgttattt tctgagttag aaccaatagc acttgttttc 513541 cacttattcc aaccaaaagg atctctcgaa aaagttatgc tattgtcact atcacaattg 513601 cttttttgag aagccaaaga gctgattggt gaggttgaag gtgtccccac accttcactt 513661 tcgattcttc tccttttatt tggtaaggcc cacgtcgacg tatcgaattt gtgttttctt 513721 gtatccgagg aataattttc acgtagacca tatggtacgt cactgctcct acttccagaa 513781 cttctgctct caacgtcgct gttaccactt gcttctactt cagaaccatc aaaattgcga 513841 ggttcgtttt tcacaaatgt gtgccataag tacttacctg agttccaaag agtttctctt 513901 atgcctccta taaaaccagc tttactagct ctatctgacc catctttcat tgattcttcc 513961 attgataaaa cacggcggtc gtttaaataa ttgaatcttg acgtattggt tcttttttta 514021 taaataccac taaaactggc tgatcttcta gactcggagg gattgttcaa tacccgagga 514081 taacacctat atgtagaaat tggggagaat aaaggggagt aagggttctt tttatgatac 514141 tgtagtgtgt tccggtgctt atctacttca actgacatta ttatgatatc caaaggtcag 514201 aggaagaaga ggaaaaaaac tgaaacagaa gtagatattg atgaataatt ttaattagca 514261 atatagattt gcggagctga aacgaacgtt tcagctattt tttgatctgg gtttaactat 514321 cacacacatc ttctcattat gtgcattttg aattttgaaa ataaaaagag gcggcgccgg 514381 cacctgctga aagctgttta atatgattta atacggaaga gcaaatatgt ataaatagag 514441 aacaattaat taattatgat agtaactggt acttgtgtaa tatatgtgta tataaaaaat 514501 atacatgttc ttattcccca accaaattga agataaaatc ttgaattggt tttagtgtac 514561 ggggtaacga aggctgggag gaaacgttta ctaatcctct ttccctccta gcggcctctt 514621 taaaagccac actaaagtta acaaccaagg taacgattaa tacaactgca accaaaatag 514681 gtcccacagg tgcatccaaa tgcttaccac ttctaccttt aataagagtt aatcttttta 514741 agtaggttct ataagcccat actccgcaaa acaaagtcaa aaagaaatat acataggcca 514801 acagatcagc tagttgtgga aattcggctt tttgcactga attatagata gaaaaggtca 514861 atacactcag caatgtggtt acacttaacc atctattgaa tgtacgttca ttggcgagcc 514921 aaacttttgc ctcaactttg acaggaccgg catttttcaa aaggtgaact ggttttttaa 514981 ctcccggagg taattggaaa gaagaggcac tgtctgtatc gtcggagtat ggatcatttc 515041 cattttctga aatatttttt ccagcaagaa ttttcaagaa agctgcattc gttttgaatt 515101 tcttcccttt tttgactgca gatttcttgg gcaatgcagt accttcttca tctgatgatt 515161 cgtgatcttc taaatctgca ataacgtggc gagtattctg atctttttgc ccttgtcttt 515221 cagtggtctt tccatctggt acagagattt tggataacct tctcatatta tcaagtttat 515281 catgaatgct cttttgtttt tgtaaagttt tcttctcttc ttcgtaagcc tcctgagggt 515341 tctttctgat gtcggtttct aaatcgggca accagaatgg caaaatgttg acatatttat 515401 cgtcttcacc aaacagtgaa gccacacctt gcaagtacaa agaaaatttt ggaacttcgt 515461 taactaaatg tgaattagtt aaatctttaa tccactcata attaggcatt tgagaattat 515521 cttggtttat aaccttaatc tccattacag aataggggaa cttcgaatat tctcctgctc 515581 ttaaaaacct caatgggttg ggaatattgg aatcaatatc gtcacggtgc caattctcag 515641 ggttcctaat gggcctattt ttgtccaaag aatcctctct aatgtacatg atattggaat 515701 cgatagtgac tctaatactt tgatctccag gaatttggaa agcagttcta ttataggtag 515761 ctctcaaaac tggctgcaac ttctcctcaa caataaagtt ttggatgtta tcaaagtctc 515821 tagaaagttt ttccagttcc tccttttgag tacccctttc tcttagttga ttaattaaat 515881 agtttttgta actgggatca tttttaaaaa taaaattgtt gatgaatttg gctttcattt 515941 gcaatctgat ttcttcaaaa cttgaattac cagtttcggt attttctgta aaagttctct 516001 tttccaaaaa tatgtcaggt ttgtctagca gtttaccgat ccatcttaat ctcagcgtag 516061 gtgcaccgct gattttcaac aatctgttat tgtacaaatc aaaaaaatcg ttgtcgaaat 516121 ataatgtagt gattgttgga tcatatgact gtgggaaaat aacgctcttt gattttccaa 516181 tttcaacatc ttggttgcta ttaccatcac tagaaaggct gttactcttt gaaccaatat 516241 tcaagcgcgc ttcaggttgt acgcggacat ctgattctag attatcgacg aaatcgtcat 516301 tttcatttgg aaccgacgca taaaccaaag caggtagatg ccttaagatt ctagccttaa 516361 cctccattat attatcatca tgaacccaaa acttgtagct tttaaaactt gcgtcttcaa 516421 ggttagaaaa atgtgataat ttagaagtac ttgctaatga tttagacacc gtatttggat 516481 gatcataatt tgatctcaag aactcgtaca gatatgagat cctatacaac aagggagaat 516541 actcttctga attgttgaaa ggaagttctt tcaatctgac ttgtaaaaga gactttacag 516601 aaggatagtt tggatgtaat ttatcgtgtt tcttcacaat cttgataaac ccagtaaaat 516661 ttaacctgtc aaagttatcc aatctttgag cctcatctag acattcttct aaggtgtttt 516721 tgaactgctc agaatttatt ttttggattt tttcagctga tttagtgttt tcctctaaat 516781 catctaattt tcgcaagaca gcattatatt tggaaatttg aaatgtgtaa accttttcta 516841 gttctttatc caaggcctcc acaaaatcag attcattcct ttcggaccaa ctatccacgg 516901 aactacggcc atcatgtatg acgctttcct ttagtaattt cttcaacctt tcatagtcga 516961 tatatgaatc cttccaggga ggatatacgt cgttagccag tttaatacca aatagcattt 517021 tcaaactctg aaaaccaagg acaaattctg ctgttcgctc taatagccaa atgacctata 517081 gtgataataa aaaaagcgct aaggaggtac tacttggatt agatcactct tatgcgtatt 517141 attacccgcc aatgggccct ctcgatattg agaagatgaa gtaagttcga gaaaagatgt 517201 ctgatgtaag ccgctctctg gcctctattt aaaagttctt cctggatgaa acccactcga 517261 aagttgggtg tgtgcgtgtg tgtatgtttc cacgtttctg ccttgtgctt tcaaaatcgc 517321 atgcacgtgc ttgcgactgc actgtgttgt attaagccac gtgggccctc gcacattgaa 517381 aaaaagaaaa gctgtacagg gaaaaatgtg ccaagaagtc caaataccaa tagctgtgca 517441 agttactcat taacatccaa accgtgaagg tcacggcata tatactctgg cgttctacta 517501 tgtggccggt aatgtaaccg gtaatggtga ctatctaata gttggagtcc gccgaaaaat 517561 cagaaacgcg taatttagac ttatataaac agctatatac cttggagcta gtgtgatctt 517621 gttgatacta ggtcggcaaa gaacgcaaat atggatttta cgtctgatac gacgaattcg 517681 cacgacacat cgaattcgca tttaagtctg gaagacgctg tgggtacaca tcatgctggt 517741 gaagcagatg taaacattga tggggacgag aagcaacaac tatcgctatt agatgatgat 517801 caggtacgcg cactgaagct acaggaggag aaggatgcgc tgttgacaag gagaaatact 517861 cttttacaag agatccagac gtaccaaaat atcttgatga aggaaaataa cagtaagact 517921 aaaaatggtg atatcctcca aaacgatatc acacaggatt ttcttaatct aatctcgatc 517981 tcatcctcta atcctaattc ggcgataagt gaccgcaagc gggtcgagag gatcaatggg 518041 ctaactaact tgcagaagga actagtaaca aaatacgaca cgttaccttt gttaaatatg 518101 aatctacggc taagttattt gagagaccac acatacccgc atcttcaagt ttctgtgcaa 518161 tcaagagaca gagtacataa cgatgggatt gaagttttgg tggtcaatta taaattctgc 518221 agaaacacga tgaatccttt tgaaattcag ttcaaaatgt tctataaatt tgaagattcc 518281 acactgctga agtgggaaat cttgcgaatt tccacaaacg ttagactgaa ggccaagcaa 518341 ttactggcaa cacgtaactt ccagaagtgt ctattaagcc tttatgagtt tgataagatc 518401 aagtccaaaa aaactggaat tttccaaaat ttgattaatt tattgaaaag gaaaaccagg 518461 tgttatctaa tgaataatag tgactcatta attgtggaaa gagttattag agaaggaaga 518521 ctcacgacga taaaattgca gataaatttc atcattacaa tgcccggtga gagaggcaaa 518581 cctcgtaact gttttctgcc catgagtaaa atttcaatag cgctatggaa ggggggagaa 518641 agatttaacc agatagattt ggacgagata tgctacggac ttatcaagga atatggtgtg 518701 aaaaccgggt taaaggagat ctgcaacgtt tgcctattcc cggacatgta cgccaggtga 518761 tgttccattt gccattgcca actggacggc ttgcttaaac gattccgata agctcggatg 518821 agggaacggt actttacaga catcatgggc ggtaaggcca agcgacaccg ccatcgatgc 518881 ttgcgacagc aattcatttg catcgtcgtt tatcatatga acgcctagta ttttcatgtc 518941 acgagaatct atcagaactt taatgaaagg agaaactgta gtattctctt cccgtggtaa 519001 taacgtgtta tatctaacgt tctgtgagaa caaaaccctg cctttttgat atgggatgcg 519061 agcctttgcc aacccctcct cagtgtatcc gacccagcca atctgaggct gacagtacag 519121 cacatttggt gggaagccac aattcgaggt tccgtcggag cctgtacagc ctattgattg 519181 aatggccctt atagcttgtt cttccgcttt cagcgccagc atggggccca atgtaacgtc 519241 tcctatgggt ttaatatgag ggtactttag cagactttgg gtttgtacgt caacattttc 519301 tacaaaatcc cgttcgtcta gaccaatgct ggaaatatct aaacctttta gcaggggacg 519361 tctaccaata gaaaccatca agacgtcgca atgatgtaca tatgttttct ttgacacctt 519421 gttaagcaag gtgatgttca gctgaccggc agcatcggct tccgcgagct gcactctagt 519481 gtctaaaaga aaagctatac cctgacactg caagagggtc ttcgtggcag aagccaactc 519541 attgtccata ttttgacaga tctcgctttg agattcaacg atagtaaccc gagagcccaa 519601 attattgaat atgcatgcga tttctagtcc aattgtacct cctcccatga tagtaaaacg 519661 tgaaggtata taatccagtg acaatgcctt atcagatgaa attatcttgt cattatctat 519721 tgcaacacca ggacactgaa taaccgcaga tccggtcgcc acaacaatat atttcgcctc 519781 tacgatgaac ggtttcatgc cgcgctgcgc aatctcaacg tggtgaggat ctttgaaagc 519841 agccgtgcct ttatacacag taacattatt tttagatagc tcacgtttat acacattgcc 519901 caactcttct atattatgtt tgagtgcact ctgggccgcc tgcatatcga attttgcagg 519961 aaacagccgc gtgccacgtt gctcgataag ttcttgctgt tgtagcagcc gataaagata 520021 agactcatat aacaaggtct tggacgggac tgccccgtct acaaggtagg cgccccccag 520081 cgaggcacgc tggtcaacac atgctgtgag caggcctgct tgcgaagcct gcatcgctgc 520141 agtaaagcca ccaggcccgc aaccaattac caggacatcg taaactgccg caaaatcctc 520201 catcgtgctt aatatttcgt cttcacctcc cattaccaaa aatgctcacc gttaattata 520261 tcatacttct cttctcctct cgtaaaatcg tgcgcatgtt aaatagccgc cgaaacagca 520321 gatgcatgcc tgcaggtctg ggtgtacccc ctgcctgagt gttccaccca ggcctcgccg 520381 gaggaaaatg ccaccgcact caagttcgca cagaaactac cgcataaatt tattctaacc 520441 cggaactgac gtttatcgtg atatgaactt tgggtatctc cgattacgaa acgacgccac 520501 ccctccttcc ccaaagcacc gagaaaagat tttttttaaa actgaacgct gattgacttt 520561 acgtattatt accactatgc attattgttg tttctgttgt ggttgttgcc agttgtaatc 520621 atattcacat tgcgttttag tcataaccac cttccggtat tcatcattcg tattgaataa 520681 caatatttat accgcaaaac actatacggc aaggcaactg attacacttt gtttacctta 520741 tttttttatt atttattttt ctagaaagta ttgttgtgtg gctctatcct tattacacca 520801 tctctgcttt ggcatttcgc gttgtttcct ctcacggatt gcagattatt gttcaccagg 520861 taataatcac tgactggcgg ctattttcct attacactca ttattcttaa aattttcttt 520921 ttctatctct attttctttc ttttcgtgtc ttataataat aataataata ataataataa 520981 aaatagtaat aataaaaata gtaataaata aagatggatt tctttaattt gaataataat 521041 aataataata ataatactac tactactact actactacca ataacaataa tactaataat 521101 aataatacta ataataataa taatcctgct aataatacca ataacaacaa tagcacaggc 521161 catagtagta atactaataa caatactaat aacaacaata cgaataccgg agccagtggt 521221 gtagacgatt ttcagaattt tttcgaccca aaaccttttg accagaattt ggattccaac 521281 aataacaaca gtaatagtaa taacaatgat aacaataaca gtaacacggt agcctccagc 521341 acgaacttta cttctccaac agcagtcgtt aataatgccg ctcctgctaa tgttaccggt 521401 ggaaaagctg ctaatttcat tcagaaccag tctccccaat tcaattctcc atatgactca 521461 aacaattcca acacaaattt aaacagcctg tctcctcagg ctattttagc caagaattca 521521 atcattgatt cttccaattt acctcttcaa gctcaacaac agctatatgg cggtaacaat 521581 aataataata gcaccggaat tgcgaacgat aatgtaataa caccccattt tatcaccaat 521641 gttcaatcca tcagtcaaaa ttcctcatct tctactccga acacaaactc taactctact 521701 ccgaatgcaa atcaacaatt tttgccattc aataacagtg cttccaataa tggtaatttg 521761 acgtctaacc agcttatttc taattacgct gcttcaaatt caatggacag atcatcctct 521821 gcaagcaatg aatttgttcc gaacacaagt gacaacaaca acaacagtaa taaccataat 521881 atgcgtaata acagcaataa taaaacgagc aataacaata atgtcactgc cgtgcctgct 521941 gcaactcccg ctaataccaa taattcaact tcaaacgcaa atacagtgtt ctctgaaaga 522001 gctgcaatgt ttgccgcttt gcagcaaaag cagcagcaac gttttcaggc tctacagcag 522061 cagcagcagc agcaacaaaa tcaacaacag caaaatcaac aaccacaaca gcaacaacag 522121 caacaacaga atcccaaatt tttgcagagt caacggcagc aacaacaaag atctatttta 522181 caaagtctga acccggcatt acaagagaaa atatctactg aattgaataa caaacaatat 522241 gaacttttta tgaaatcttt gattgaaaac tgtaaaaaaa gaaatatgcc gttacaatca 522301 ataccagaaa tcggcaacag aaaaataaat cttttttatc tttatatgtt ggttcaaaaa 522361 ttcggtggtg cagatcaagt aacaaggacc caacagtggt ctatggtggc ccaaaggctg 522421 caaatttccg attaccaaca attagaatca atctatttta gaattttatt accttacgaa 522481 agacacatga tttcccaaga aggtataaag gaaactcaag cgaaaagaat attcttgcaa 522541 cagttcttac aagaactatt gaagaaagtt caacaacagc agcaggccgc tgcattggcc 522601 aatgccaaca ataacattaa tagtgcatcg tcagcaccaa cccccgcggc tcctggcgcg 522661 tccgttcctg ctacagcagc accaggaaca gaagcaggga tcgttccggt ttcagcaaac 522721 actccaaaaa gcttgaatag caatattaat atcaacgtaa ataataacaa tattggccaa 522781 cagcaagtta agaagccaag aaagcaaaga gtgaaaaaaa agaccaaaaa ggaattggaa 522841 ctagaacgta aagaaaggga ggattttcag aaacgacaac aaaaactttt agaggatcaa 522901 caaaggcaac agaaattgct attagagaca aaattacgtc aacaatatga aatcgaacta 522961 aaaaaattgc ctaaagtcta caagagatca attgttagga actacaaacc cctaatcaac 523021 cgcctcaagc attacaatgg ttacgatatc aattacatct ctaaaatagg agagaaaata 523081 gattccaaca agccaatttt tctcttcgcg ccagagttag gtgcaattaa tttacatgct 523141 ttatcaatgt ccctccaatc gaagaatctt ggagaaataa acaccgcctt gaacaccttg 523201 ttggtcacaa gcgctgactc gaacttaaaa atatctctgg tcaaataccc tgaattatta 523261 gactccttgg caatactcgg catgaattta ctgtcaaatt tgtcacaaaa tgttgttcca 523321 taccatcgaa acacttctga ctattattat gaggatgctg gatcaaatca atactatgtt 523381 acccaacacg ataaaatggt tgataaaatt tttgaaaagg taaacaacaa cgctacactt 523441 acaccgaatg attctaacga tgaaaaagtc actatcctgg tagattcttt aacaggtaat 523501 caattgccca cccctactcc tactgaaatg gagcctgatc tcgacactga atgttttata 523561 agtatgcagt cgacatctcc cgcagttaaa cagtgggact tattgcctga accaataaga 523621 ttcctcccta accaatttcc tttgaaaatt cacagaactc cttatttgac ttctttgaaa 523681 aaaatcaagg atgaaattga tgatccattt acaaaaataa ataccagagg ggcagaggat 523741 cccaaagttc tgattaacga tcaactgtct accatctcga tgattttgag gaatatttca 523801 ttctccgata acaactccag aatcatgtcg agaaattttt acctaaagag atttatatct 523861 gatctacttt ggttagtctt aatccatcca gaaaacttta catgcaatag gaaaatacta 523921 aatttcaaga aggatttggt tattgtttta tcaaatattt ctcatttatt agagatcgct 523981 tcgtccattg attgcttgtt aattcttatt ctagtcataa gttttggtca accaaaactc 524041 aatccaatgg cgtcttcgtc atcatttggc tctgaatctt tgaccttcaa cgaattccag 524101 ttgcaatggg gaaaatatca aactttcggt gtagatattt tggccaaatt attttcattg 524161 gaaaaaccga acctaaatta tttcaaatca atccttctga acaaaaacac aggtaacaac 524221 ctctatgatc gcaacagtaa caacaaccac aaggacaaaa agttgttacg aagacttttg 524281 aatttataca atgataacaa taaaaataat aacaataggc acaacttgct aaatgatgtg 524341 gtttcgtttt tattttctgc cataccgctg cagcaagtgt tatcgcaatc agctgatcca 524401 agtttgctga tcgaccaatt ttctccggta atttctcaga gtctaactag catcttagtc 524461 attgtacaaa aaatattgcc gttatccaat gaagtatttg aaatcagtga gaataattca 524521 gacagtaaca gtaacaataa cggcaacaaa gattctagct tcaatttcaa caagaattta 524581 ccatttgtgt ggttgagctc tgaagaaaat attggatctg gactattgaa gttaagtgag 524641 ataatattga atattaacaa ttccacaagt aagaatactt tgttacagca acaaaattat 524701 tcaaaggtgc tcctaccgtc aattaacata tcctgtgttc agttaatcaa atgtttggtt 524761 gaaaaaagta tttgttttga aaactgccta aacaacgacc cggaaatatt aaaaaaaata 524821 gcatcgattc caaatttgtt ccccacggat ttagaaattt tccagttatt cactaatcca 524881 tcagttgata ttcaaataat aaaccagtat caattacttt acaatttaaa aaatgatatc 524941 ctaaccaatt tggaatgatg cgattttttt aaacaatatt cttttactgc ttatttcttc 525001 cttgcgcact attttctttt tataaaccta tataaaatgt tgtaactaat ataatagacc 525061 ttatggaaac aatacagtcg gaagagcgcc tttagtgcca aaagcccaaa tgaacgtata 525121 gctgccatga agtcacatct tgggcggctc aactaaacaa tggttttagt aacttcccac 525181 tggtcccgtc gcggctacaa aaattccttg aaattgtata aaggagttta tgactccatt 525241 tcaggcagta aatacaattc atacacacca cacatacatt cagagttaac gttcgctata 525301 ataaaacggt agagagtcag atgtggagtc agcgtggggg gtggggtaac actccacctt 525361 tgaaaacggt gtgacttcgc cctttcgatg ggaggaggta aagctcaaat aggacagaat 525421 catccaagaa aatttcaagc tgcccacaaa gtcaagatcg cttcagaagc tgttcggcgc 525481 agtattgaga tgaattggct gcattgacgg ttcgggaacc cattctactt atctatatat 525541 tctgagtact tatccagaaa gagaaaaaag tcagctggcg ccgtattttt tatcaaacct 525601 aattggctaa agtagaattg cacgtcagag cttacaaatt tttcgatatc tataaggggg 525661 tggggggaaa gaatatgtat gcaatgtcaa acgcgtagga aagccaagct caattacgcg 525721 tctcttttat ttttaaacta tcaaattgcc gcgcatgcta gatgaataag gaaaaaaaaa 525781 gggggacgga aaacattgca accaacacat tattctttag cggctttttg tgaagaagag 525841 gagttgcttg ctccatcttc atcgctgtca tggccattga gacgctgtag cttcttatcc 525901 ttcttgtctg cactctcatg ttcagattga tccaaactca aattctctaa atcatgtaca 525961 atttcaagta attgctcttt agagttatcc cccattccac cttgggccgt aagtatcttt 526021 tcgaaatctt cttgccaacc taattcttca acgagttgct cggcaaactc atccgagtac 526081 tgatgaacta ttaaatctgt aggcctcttg ttagctttaa aatcgcccac cgtttccaaa 526141 ttgcacagaa ctctttttac ctttcgagga atttcttcgg gcagagacgc aaagggataa 526201 acggctagtg aggtgccaac gacgatgaca agaggctgct gaggatgttt tccagatgtc 526261 gtgatttttt cacgaagcca ctctgaatcg tttaaccaag tttccgaaaa ggaatccggt 526321 agatcttcgc caaaaaaaac tattgccggc tttaccagtt caccgcacac atcacacttg 526381 acaaaatcct ttataggatg ctctgccagc ttggatttga aaacctgtgg gggataaact 526441 ttaccacatc cgatacaatg acagtgagca aaactgccat gggcctcgat gatcagatca 526501 tccttaacac cggcctgtct ttctaaagtg tctatattct gggtatatac tctcttcaaa 526561 acgtctttgt cttgaaacaa tttcaaaaga tagtgaaact tagaaggtct gaaatttccg 526621 ggatacaact ctttagccaa agtgtaaaat ggcaaaggat ccgattggaa aaaatcgaca 526681 tcgaacactg cttcagggta cggcaacttc aacctggcca agttatggta caggccagtt 526741 cccggagatc ggaagtctgg tatcccacaa gaagtggata tcccggcacc caccataaag 526801 attactttag cgttggggtt gcttttcata tgagcagcga tcttcctaac cgacatctct 526861 gtagaggcgg tagaaacaga catcgaaaca cggagagatc gcggtacgtc tggttggtag 526921 ctcagtgacg ggcacagata gcgacattta ctgatacaga gacagttacg aaagatggaa 526981 acacatgcag agaatgtggt ctattcctta ttcttaagat cggcgaagct aacagagtta 527041 atgctgggcc atagctggac ggcagaaagc acgcaggcag ggggcctctg cgtagggcgg 527101 gagacgcctc cgtaaggaaa acggcgcggg aagggcggct tcttactaca tttttttgcc 527161 actccggaac tcgcgcaggg ggaagacata tgcccacttt gggaaataga aatggtcatt 527221 ttaagctcaa gtgaagcgaa aaaaggaggt atactccttt acgcgtcacc caatctggat 527281 aggcacgtca aactcattag gtctcatcaa gaactagtgt agaaatgacg cttgaactcc 527341 gaactttaaa caaagttctg tttttgtttc tgtttctgtt tcctgttgct gtctctgttt 527401 ctattttttt cgtatagctc tatttccctt gtagataaac atatataaga atgctattat 527461 agaagcgtgt attttcctcc ccctagcttc aacctgtaat tcccttctta gtaaagcgaa 527521 ctagaaccag tttaatagga tatagaatgc tgctggaaag attgcacaag agattacacg 527581 ccggctcttc taggcgatct caagaaaata aggacaagaa ttgcaagccc gaagacgcgt 527641 tgcccatcca accagaagct caacatcaaa ctcaggaccc tcagccgttg ttaaattgtg 527701 attacgatga catgattgca tttgacagaa acttgtccac tcccgttttc actccggtaa 527761 tgactcctat aaataatagc agctccaatc aggcgaaaag ctcggatgcc tcgtattttc 527821 caccttacct caatgctaat agaaccagac agaatagcgc ctcttcgctg gcgagttccg 527881 tttccgattt cgctcagaat ttcaaacaac atacctttta caacaataac gctcaattca 527941 cttcgttcac accgcagttt gtcggccttc tattagaagt ttaccaaaac acgtgcagcg 528001 atcctacgat aactccgttt gatactacaa accctccctc aggaatattg aatagagttg 528061 ccaaagcggc tatacagcaa tctgagcttc aacaattgga tatcggatgt gacagaaata 528121 gctggctttt aacattggta agacagcgct tgttgcaaga ggtcagaaaa gacggctatc 528181 tttctcgtaa cacttcttta acttctttac ccccaccacc cccaccacag ttttctgaaa 528241 tgcttagagt tccctccccg tttgttaacg cagatattac cgatccaatc cccttatcaa 528301 acacaaactc gaatccgaat gtaagctcta ctaccagcct gaccaacacg ttgaactggt 528361 attccttaca aagatccaac gtctcaatga agaatagaaa tggctcgtcc cagtatattt 528421 cagaattaca accacaacct atcttagccc gcacaaattc taacaatagt gttagcaaca 528481 gtaatgcctt ttctttactc acgccaacgc ctacaacaga ttccgcattt aattttaaca 528541 tagctctgct atcgagacaa cgtagcaata tcatatcgtc ccccttagct agtactcgtt 528601 tacctacagc aaacgtgtcc actgaagaat cctctatttt accaaatgaa tcattgaagc 528661 taaaaagaga tttattgcgt cttaaaaggt aaatagtgcc gaacagtcag gagcacacaa 528721 tacatgacct ataatgacac tatcttaatg aaattctatt acactttctc ttttcttcac 528781 attcgattaa gaatttaatt tattccattt caagtctcat tctccatttt ctggttggcc 528841 atagatgtat tatttacaag tctgatagat ataaaagcgc caagtaaaac atatatacaa 528901 catatacata tacacctcgc atcaattaaa acacgttcct ttgctttcct ttctttttct 528961 tttttttttt ttttccgatc tttttcactc caatgtttcc attctttcaa atacaacttt 529021 cctattcaca ttgctgttct tactagtggc ccatgcatca tttaatatac cagcctttcg 529081 taatagttta gtaactgttt cgctaggttg tgctcccaca ccaatccaat attttgttct 529141 atcaaaatca agcttcacgt ctttaatagg tacaacgccc ctcttcaatt ctctcttggt 529201 cactgggctg ggtaccggca cgtaggttcc tagtacctcg atcggtttag catccctcgc 529261 cttacgggaa ttagccacta cgatattata gaccggacta ttttttcttc caaatctagc 529321 taaccttatt cgtactagac cacaggtcat acttgataaa ctctattaca atttcttaac 529381 ggaataccag tcagaactcc tccgttactt aagtcgtgta tatattcccc ttcctttttt 529441 cttacaactg ttcttggtgt actatttcat tttttccgtc ctgaatgata gatgatcata 529501 attagtgaaa atttttcttt tcgctgcagt gtttaaaatt ttaattatat catctcatct 529561 catcgcgcaa ttagaacttc ctcggtcgca gttaattctc tcagagaaga gttttagttt 529621 gaaaaggttc aacttatttt tttactgatt gaattcaacc aggtaatttc tagattttga 529681 acagcatctc gcgaattgaa tcagcaaatc tcagagttca tcatggatca agacaaagtt 529741 gcttttcttt tagagctgga ggacaagctg gctaaaattc gttcccaagt aaactctaaa 529801 ttggagaatc aaaagcatat tgctataata ttaactgccg ttgaggaaaa tattgcaggt 529861 caagctacaa atgatgtttc aaaaaacatt gtaaattata tcatttcctt tatgtcacta 529921 ttggatcaag cagtagaccc atctactcat gaaataaaag atattcaatt ggcttcctca 529981 tctacatatc ttctagatct gatatttcat tattcgccta aggtattatt aagatcgaag 530041 ttttctgaaa tcctaacgaa aattgcccca tgtatcactg cagaaaaggc taatgcccct 530101 ctaattagag ctgctattgg ttgtttagaa tctcttctta ttgctcaaga tgcacaagcc 530161 tggaacaata cttatgatct aaacgtcact ccaaaaagag gtttgcaggg tatacttgaa 530221 ctttctttag atgtaagacc aaaagttaga aagagagcgc tagatgcagt tcatgcggtc 530281 ttattaaacc ctcctgttgc accaactgca gagcatgtag cggcagtttt tgtagcagat 530341 ttctgtgaca agcagttagc aggtatttta aatgatctct cgaatttatc aaataaacaa 530401 ttgaaagcac agaaaacaaa ggaagacatt aacgctagtg tcatgcgctc tctaaggttg 530461 attacttcag tcgtctctac tggacagtgg ccatcttcac agattgagcc tctttgtgat 530521 gtactattgg gagtcaccaa aagctcagag caatatctcg tttctgcatc atttgaatgt 530581 tttgaaagca tgttcaaaac aatggcagaa actaccattt cttctggatt ggctgaaaat 530641 aagtacctaa gagtcttgga taccattttt gcattaaaac cctcaaatgt cgatacatta 530701 ttaaccaagt cctggattgc tgtggtcatt aagggtatgt ccacttacgc aacacatcaa 530761 ccactgaaag cgctacgtaa aattcctggt gtatttcaca ttatgtgcac atatttagct 530821 agtgaaactc cagaagtgta ccaagctgcc tctcaatgtc ttatctcaat cctttctgag 530881 tctgttaaag atgatttgtt attgtataca ccaagtgtgg atgagaaagt tttcaaaaac 530941 gtagatgaaa tcatctctca aattgcgaaa acatttatcg actttttatc cattagatat 531001 tcccattgtt ccagagaaat tcttaagatt ttggtggcag cattcaacaa attcagatat 531061 agatctaatc ctcacttttt aaaatcactg aaaatagtcg atacatggag agtaaatgaa 531121 gaacagttta tggatttgag aaatgaaatc gaattagtaa tcggagcctc catttctgct 531181 atgggccctg aaatgatact cgcagaagca cccctgaatt tagacaatcc atcttccgaa 531241 agacctggca gggcttggtt gttaccgctt attagagatt atacgaaaaa tgcgaacctt 531301 gcaacttttc aaaacgaatt ggcaccatac attaaaagtt ttcaatctaa gttcgataaa 531361 gtcccggaag aatctattca attgagagtt tttcaaacta ttgttgacca aatctggtct 531421 acacttccac ggttttgtga actcccaatg gacttgaggg aatccttcac tgacgaattt 531481 gcctcagaac tatcttcttt attatacagc gaggttgagt taagaactac aatttgtcat 531541 gctttaaagg tcttggcaga aagcaatgtt tcatatgccg aagagtcctc ttctcacaac 531601 gttttattgt tgcaacgttt ccccatttct gaagctcaaa agaatataga atacctttca 531661 accaaatcaa cgaatcttct agcagttttg ttcaatgttt atactcaaac cactccaaat 531721 gcaaggagtt atattttgga aacgattgat caatatttaa agattacttc aaaggaagat 531781 ttggagaaaa ctttcaacaa cgtatgtggt cttttgaaga attctatgaa tgaagaaagt 531841 agcggaaatg tgaacaaaga aaagaaaaag cctcaattga cagcgacact attggactta 531901 atcatatgta tgataacata cttacctgtc tcgtcttatt ctgctttatt ctcaatgttt 531961 agcctcaccg taaattctgc tgacgcgcta attcaaaaaa gagcttatag aattattaca 532021 aagctttctg agttgaaatc gggatcaaca gctgtcgccc aattcatttc ggatattgag 532081 aatgtcatgg tagatagcgc ctcctctgtt caaacatctg ctaaagctgc aagattaaca 532141 gcaattaaaa ccatagtaga attattacct ttagatcatc ttgatttcat tgttagaacc 532201 gtcgctgagg ttattttgag tacaaaggat gtgaatgaaa aatctagaga gaccgctttt 532261 gatactttaa tttgtatggg aagaaaaatg aatgagccaa atggtattat caaattattc 532321 caaataccag gttatgatcc taccactcca gatcaatcgt cgtcaatatc agagtttttt 532381 aagatcattt ctgccggtct tattggtgaa tctcaacata tggttagtag ttcaattacg 532441 ggttatgctt gtttagtttt tgaattcaaa aatgaactcg attccggtat actaatggat 532501 atatatgaca ccattgaatt gtacttaact tctaactcta gggaaattgt aaaaagcgcc 532561 attgggttta ccaaggtttg tgttttgggg cttccagaag aactgatgag gccaaaggtg 532621 ccagagttac ttctaaagtt attaagatgg tctcacgaac acactggtca tttcaaagcc 532681 aaagtcaagc atattattga aagattaata aggagatttg gatatgacta cattgaagcc 532741 aacttccctg aagaagatag gagattatta acaaatataa gaaagatgcg caataggaat 532801 aagcgtaaag atgaagaagt tactactgga gttagtgatg tagctgccac aaagggttca 532861 agatttatgt ctgcattcga tgaagctgtt tatgggtctg atgaagaaaa tgataatgga 532921 tcagatcagg aggaaaatgt tgctggtggc aaaatgaaga atggggcaaa gcaatttatt 532981 gtagaatccg gtgacaaccc actagatttg ttagattctc aaacactagc tcatatatca 533041 tctaccagac caaagaaatt caataagaat caaaatagag caaggtttaa tgatgatgcg 533101 tttaactttg actcagaagg aaaactcgtt gtcaaggggc aacctaaacc ctctactaat 533161 gtagacgatc cattgagtgc tgtgacaagc ggaatcaatg cgtatctaga ggctgtgaaa 533221 agtggtcctg taagaggtca aagaaacaag ctgaaattca ggaaaaatgg aaaggactct 533281 gatgaatttg gcgatgatga tgatggtgaa aaggatagta ggctaatgag aggaagagta 533341 aatcaaggta acaagattgg caaacataat aagaaaggtc caaagttcaa atctagaaaa 533401 aaattataga agattgaaac tgagcaatat ggctaattac acacctggag aaaaaatcag 533461 atatgtatat ataagaatat tataatactg tatattaaaa atgattaaaa taaagaaaaa 533521 aatgaatcgg gcgtttaatt gcttattatc ttgaagaagc gaaagtacac tatatagtaa 533581 taatgtgagg ttaattaaat atggatgaga taatgacgaa agaaaatgca gaaatgtcgt 533641 tttaaaagta acccccataa tctagtgagg ttcgacgttg aaatgtgctg tccatatctt 533701 cctgctctgc ccatttagta tcaacatttg agtcgaattg aaacattgat atgtcacggt 533761 catcaccatg aggagactct gttaaacttt tattgttctc tttaaaactt tcctcattgt 533821 tattttcttg agacttttgg ttagggcctt ccacttcgcc aagtgattca agctcctcat 533881 cctcaaatga aagagttata ttttctaacc tattttcttt tctcattatc ggcagtttgc 533941 tagttacaaa tggattttct tggatctctg ttaaggcatc ctcatctctt ggggtcatcg 534001 ccgaaggcat cctatcttcg tttgttatgg tagtgtggtg atggcggctt agaatggaag 534061 atttatagcc tgcaatatgt ggtaaagccg gtacattttg agattctttt ttggaagctc 534121 tttcaatcat gtttatacgt tgtctagcaa tgactaattt gatccaatca tctaatccat 534181 tattatttat tagatcttct atcaactctg tttttctatt ctttgtttct aatttctgtt 534241 tcgcaccctt gttttgcagt aattgattga gatagtcagg tattgctgac aaaggatcag 534301 attctttttc ctcactttgt agtaattcta ctgtgggtaa ggcagttatt cgcgcgtcgg 534361 tcaattgagt actataaata caccagtcct tgaacttttc cattcctcgt gaacttgata 534421 attcggagtt ttcatcatag acatccagaa cgttcgtagg cttaacaata cctagatttt 534481 ccagagccag agttatatct tgtaaagcaa ttgtatcgtc ctgatcacat cttgcctgag 534541 cgatagaact gacctctgat gctaacaaac tcaagaattt tgcatagaga tcggtcatga 534601 catccaccag actgggcctt gccctgtcaa atccttgtgc cttcaataat tggagaatag 534661 atatgcgtag tagagcaaaa tagaagtcat tatttgtagt catagcagag gaactctatt 534721 gacccaaaga tatcgctgtt ttccgctagt aggtgatttg gaattgctca ggaagctact 534781 tcaagtgtta tattagcata ccttcatcat gcaatatgaa attactgaaa aaaaaaacta 534841 aagcatcgcg agcttacccg tttcgccact tctgtcaagt gaaaaaacac gtttgcattg 534901 tttaggctac aaggtgtgga atatcgaagt tattgctaga cagaagttct ttaggcattt 534961 aggttttgtt tgtgagctgg cttgctaatt ttgagtactg tgcatcattg ttccaggatg 535021 tcttctttat cgctatatac tgttcaggct gttttaatac tagatcagca aggagaacga 535081 atttatgcaa agtattatca acctcctcat agatctgatg aaggacacca attgctcttc 535141 aattcggtga agaagcaaaa agagtttgag aaacaactat accgtaagac tcacaagcaa 535201 gattcggaga ttttaatctt cgaggatcat ttagtccttt acaaagaata cattgatatc 535261 acgatatatt tagttgcttc gctggaagag aatgaaattg ttcttcagca aggattttca 535321 gcaatcagag gagctttgga tttgattttg aactcaggaa tggacaaaaa aaacatccaa 535381 gaaaactatg atatggtttt attagctatt gatgaaacca ttgataatgg tgttatcctc 535441 gaaactgact ctaacactat tgcatccaga gtttctaaac cacctacgaa cgaaccccaa 535501 atggcattag atttggataa gggtttctta ggcgcgtggg gtttcgcaaa gagcaagttt 535561 caagaaaggt tacagcaagg cttatgatca caaggcaaag cggatagaag aaaattttag 535621 ctggtcttat atggtatata tgcagtgtct tactttctcc cttccatata tatgtatcta 535681 cttatatata taagtatatg ttgctcattt agaaatgatt gtcacctcat gctaatcatt 535741 ttattcttct cgttggtctg tgatgaaaaa taatgaaaaa attataattg ctgtctattt 535801 tcttttcatc tcatatgatt tagcgttttt ttttgccctt cttcgaagag ttaccaccgt 535861 tcttggtgga tttctgccca gcgattgtta cttttaactt gtcgacacag agcagaagaa 535921 ccaagtcctg ttccttcaag cctttaatca tttcatgttc ttggggccaa tccatttcgt 535981 tgtcagttga agaaccgtct agtggtctac tcttgaaata atgtaaaatt tcagttaaag 536041 tcttagtttt cttcgcactt cccggttgta ttttgacttt gtatttatat ttcaaaagcg 536101 caggccaggg ggcaaatact ggtataatat catcaaccac atcgccctta tcgagagatg 536161 gttttaattc ggacttgtgt ttatcatagt tcactcttgc tttctctttt ttggtgaatt 536221 ttaaagcctg tagtcttctt tgtttctcgc gtttattctt tctatcttct ctaacttctc 536281 gcttcattat ttcttctttc ttcctttgtt gctgcttttc gatacccttc aaagtaccca 536341 aggcctccaa acgcaagaga cgttcagttt catcctggtc ggcgtatttc ttttgaattt 536401 tcttcaattt tcctctttta ccacggacgt tactgtttat gttttcgatt aaagatatcg 536461 gaacacctgg ttcatcaagg atacgctgcg tactgctatt gtcatttttg gctttagcat 536521 ttccagaatc agagtcggta tcggatgata tggtgcaatg cttttcgatg tctttttcaa 536581 gattatcgtg ttcaaaactg ttgtttttcg tgctatcgtt tgaatctcca cccttctcta 536641 acccattgac ctcgttacta tcgtcttcat cttgctgttg ctcttcttct ttttcttctt 536701 cttctttttc ttcttcttct tcttcttctt cttcttcttc ttcttcttct tcttcctctt 536761 cttcttcttc ttcttcttcg tcatcatcac cattatcctc atttccactg gttttcactt 536821 tccataaaaa tccaaaaccc atcacaagtt gagcaggggg taaatggttt tgatcattct 536881 catttttcaa ccgaaaggca ccttctggca gaatggagtt atcagagcca tcgaatttac 536941 taacattctt tgcaaagcac caccatggag aagaagatat cttcttcgac caagcctcgc 537001 ttgaggacat gcatagtata cccgcttgca tcaaagtgtt cggtggaact tctgtttttt 537061 ctggattttt gatccataca tgagagttaa aactattgga catataaata tcatcatctt 537121 caatatattt tgaatagatt tgatctgtct cagccggact tttacccatc atgaccaaaa 537181 atccttcact tgaaataaac caactatatt tttcaaaaaa gtaaggagtg cggatctttt 537241 ttaagacact gtgagaatct tttagctttt ttttcaattg ttgatcaatt ttgacttcaa 537301 tattcttcat agccttgccg acattctttt cgactttttt ctgcttttga gcacttgttt 537361 ttttgatatt gaaatattca gtggcattgg cataagctga taaaccaagg tcaattgtaa 537421 cgtttatctt ttcattagat tttcttttca tactttttgt actcctctcc ttcgaactct 537481 ccatgtcttc tgagtctgag tcactagaac tatcagtagt attgccttct gattcattgt 537541 cctcgtctga agaagtgttg agttccttgc tagagagatc aagcttgacg ctaattttgt 537601 tctgtttcaa gttcaaaggc aagttcaaaa gctgagcaat tctgttgcct tttttttgtt 537661 cacttttaat tagtttctca atagtgttcc agtccatttg ttgatcgatt agaccctgaa 537721 cagcaagctt aacttcctct attaagggtg cattttcaat tatgagatgg cctttccttt 537781 catttagttc ttggacgtct aataaagctt gtatttttct atcattttcg gcacgagcat 537841 catcgatttt cttttgcgct tgcgattcct gattttgtat acgtagagca tacttagagg 537901 attctattgt tgagaaaaat ttgtctagcg tcctattgta aggaccttca acttcaatga 537961 tacaagaaga gtcagtgtct cccccattta tatatggctt aaagggatgg aatgtatcat 538021 aaataaattc caaatcggca gtatcttttt cagagatata attttcattt cttttggcca 538081 aaatgtaacc ctttctatcg gtggtagtta aaagttgatt atattctaac tgagtactgt 538141 ttagcaattc ggcgagtgag tctgtttcct ccaaaagatt taaacaagac tctgaagggt 538201 cgatattgaa taccttaagg ttctttgata ataaatctga agacaaatga gggactttcg 538261 aaagcagcag tttatggatg gaaggtactt tcactttttt ttttttagcg ccctccttcc 538321 cttgaatgtt aagttgctta ataacagtaa tgtctgattc atacttggct tgaactgctt 538381 ttatccactc gttgactagt tcagaggtgt attctgcctt tctgtttttt tctatggatt 538441 catcagcaga ctcgttattt gtggtaaaaa gtgattcgtc aaacatttca taaatttgtc 538501 cgaccttatt ttcatgctct agaacgactc tttgcaaagc cataattctt ctgttctcat 538561 ctagaagaat gacattccct gcactgaaaa attccaaaac taaatagaag tggccatcag 538621 caaattgtag aacaagaatt ctatcctggt ctacttgctt taaagctgtt aaccgtttag 538681 ctttaagatg cttccttagt ttgacaacaa agccggaagg agttggaggt attggcctac 538741 taaattcagt taagtaaatt cttaagccac aatcgacaac aacattgagt ttagaatctg 538801 gtttattaaa tttcagcaaa aattgttttg aggaatcggc aatgttatat atattactca 538861 atcggtagcc ttccaaatcc tgtttcagct ctctagccaa cagcagtaaa tctagggcac 538921 taattctttg cttcatcgct attaatctct tgcctgcctg acttcttaga ccggataata 538981 agtagcaact ttcttttcaa tttgccatcg gattctttta aaactatttt tcaggcgaaa 539041 tttcattttt ctatccttcc gcagcatgaa tgaaaagttc aaacgcgtcc aaatatacaa 539101 tagatatagt gcattagtta atgtccggaa gagaagtcgc aattgttgaa aaggttaaaa 539161 ctcaggctat ttattgaaaa tccaatttta atcgtaacca cagagttgag gtagaggctc 539221 atttgttacc tgacagttga tgacattatc actgacatat ttaaattcat cattagtgta 539281 atcagcacat gctaagttga gggcactact gcaacttcag tttgtttcct taaaacccaa 539341 aagagtagaa aaccaggcta aaaacagtca cactagtcca aaaaatggac aaaaaggaat 539401 attcggagac tttctatcat ccttataagc cctatgatat tcaggtacag ttaatggaaa 539461 ctgtatacag agtgctatcc gaagggaaga aaatagctat cctggaaagc cccactggga 539521 caggcaagac gctgtcctta atctgtgcca cgatgacttg gttgagaatg aataaagcag 539581 atattttcac ccgcatggaa actaacatca aaacgaatga agatgatagt gaaaacctaa 539641 gcgatgacga gccagactgg gttattgaca cttatcgaaa gtctgtttta caagaaaagg 539701 tggatttgct aaatgattat gagaagcatt taaacgaaat taacacgacc agttgtaagc 539761 agttgaaaac tatgtgtgat ttagataaag aacatggaag atataaatca gttgatccat 539821 taagaaagaa acgcaaaggc gctaggcacc ttgatgtatc acttgaagaa caagatttta 539881 ttccgcgccc gtacgaatca gattctgaaa acaatgatac ctccaaaagc acaagaggag 539941 gaagaatatc tgataaagat tacaaattga gtgaactaaa ttcacaaata ataacacttt 540001 tagacaaaat tgatgggaag gtttcgagag atccaaacaa tggcgatcgc tttgacgtta 540061 caaatcaaaa tccagtgaaa atatattatg catccagaac ttattcacaa ttaggtcaat 540121 ttacttctca gttaagatta ccctcgttcc catcatcctt tagggataag gtcccagatg 540181 aaaaggtgaa gtacttacca cttgcttcga aaaagcagct ttgtattaat ccaaaagtga 540241 tgaagtggaa aacattggaa gctattaatg acgcatgtgc ggaccttaga catagtaaag 540301 agggatgtat cttttatcaa aatacaaacg aatggcgtca ttgtcctgat acgttagctc 540361 tcagagatat gattttttca gaaattcaag atattgaaga tttagttccc ctgggaaaat 540421 ctttgggaat ttgtccctat tacgcctcga gggaggcact tcctattgcg gaggtagtga 540481 ctttgccata tcaatactta ctttctgagt ccacccgttc aagtcttcaa ataaaccttg 540541 aaaattctat agtaattatt gatgaggctc ataatttgat agaaacaata aattctatat 540601 attcctctca gatctcgttg gaggacttaa agaattgcca taaggggata gtaacttatt 540661 tcaacaaatt taagtccagg ctcaatcccg gtaacagagt aaatctatta aagctcaatt 540721 cacttttgat gactctgatt caatttatag ttaaaaattt caagaagata ggacaagaaa 540781 tagatcctaa cgatatgttc acaggaagta acatcgatac cctaaacatt cataaactat 540841 tgagatatat aaaagtctcc aaaattgctt acaaaattga cacgtataac caggcactaa 540901 aagaggaaga atcgtcaaaa aatgaaaatc caataaaaga aacgcataaa aaatcagttt 540961 cttctcagcc attacttttc aaggtttctc aattcctata ttgtttgaca aatttgacgt 541021 cagaaggaca attttttttt gagaaaaatt attcaataaa gtacatgctt ctagaaccaa 541081 gtaaaccttt tgagtcaata ctaaatcaag caaaatgtgt agtccttgca ggtgggacaa 541141 tggaacccat gtcagagttt ttgtcgaatt tgctacctga agttccttct gaagacatta 541201 cgaccttgtc gtgcaatcat gttataccga aagagaattt gcaaacttat atcacaaacc 541261 agcctgagct tgagttcaca ttcgaaaaaa gaatgtctcc ctcccttgta aataatcatc 541321 tttttcaatt ttttgttgat ctgagcaaag cagttcctaa aaagggtggt attgtagctt 541381 tttttccaag ctatcagtat ttggcgcatg taattcagtg ctggaaacag aatgacaggt 541441 ttgctacatt aaataacgtg aggaaaatat tctatgaagc aaaagacggc gatgatattc 541501 tatctggata ttctgattcg gtagcagagg gaagggggtc tcttttgctg gctattgttg 541561 ggggaaaatt atcagaggga ataaattttc aagatgattt atgtagggct gtggtgatgg 541621 tgggcctgcc gttcccaaat atttttagtg gagaactaat agttaaaagg aagcatttgg 541681 ccgctaaaat aatgaagtca ggcggaacgg aagaggaagc ttcacgagca acaaaggagt 541741 ttatggagaa tatttgtatg aaagctgtca accaaagtgt tggacgtgct atacggcatg 541801 caaatgatta cgcaaacatt tacttgctcg atgtgcgata taataggccc aatttccgga 541861 aaaaattgtc acgttgggtg caagattcta tcaattccga acatacaaca catcaggtca 541921 tttcttcaac acggaagttt ttttcaatgc gcagcctgaa ttcacgctaa aaggaatacg 541981 tttacgtgta tactgtgatt actactatat attatagtaa actaaactga tatttatgac 542041 tactttttat atctgcaagt aattctttgt ctcttgtatc cttacataac ttccagcgtt 542101 gttccacaat atacgcttat ttcattaaat ctttctaata gaccccttgt aaaccaacca 542161 taatcattca aatcatctcg ttttatgtct attacccgtt gtttgctcac gggacatatc 542221 tttacatgcg ttgtaagtat tggaagcaaa gtgacaccac acctcttcca cgtgttattc 542281 gtggtggatg ttacagtttc agggtcagcc gtgaagcttt ctaaattgaa cgtttcctcg 542341 agaaagctgt tcttcatcaa taacgtgccg ttgtaaattg gcgcttctct tttaagtatt 542401 gccgctatag ataatacgca agctaaatca aaactattcg ttaattcgga ttttttgttt 542461 atagcgtatt catataaggc ttccaaaaat gacaaaattg acggtttatc gatagtcata 542521 ttcaagaaca ttataatcct catctcttca cttttcatta atgcattgag gtatgattgg 542581 aaatccagac taatagggta attaccattc agtaatttct tgttcatact gaaattttct 542641 ggaagtttgg gcagcgattg gttgtaaatt tggtacgtct gataccacgc taatccaaca 542701 gcacgttcag aaattgtcca agtatgatat agtggggcga acatgatgtt aaacgattgt 542761 tctgaagcta ttttatattt gaaagccacc cgttccatat cgtatactat ggctattgaa 542821 tagccgtctg gagagagaga tattccgtgt atgacaagag ttgtttcata attattgaat 542881 tcattccaaa ttgtgctcca tttcttgaat ttcttctcta agtaaggcgc gataatatta 542941 tcagccgtca catgaagttc gtcttctagt aaaactttat aactagtctt attggacatc 543001 aataatatcg tgctctcttt ctcatgattc aatgggatta tatgaaaatt ttcgagagat 543061 cctgttttca agctagaaat tgaataattt tttaaatcta tcttatgcac atatccggga 543121 caagttaaaa ccaccttata atccactatc tttaaatcag taatttttct tctcgaagca 543181 ttttgtatca ttctagaaac gggttgatga gaggaagcag aaactgtcat tgaaaataca 543241 gaattgtttg aaagcgccgc tacaagaacg tcttcgtacc atactatatg agtgacccag 543301 tcttttgagc ctgcgtcact taatctaata ctactctcaa aataaaattc tggagtattt 543361 tctgaatttt tgcgaatgct aaagaattga agctcaccgt cttcattacc aaccacgatt 543421 gatgattcaa taggattcca ttcaaaacaa tggtaggttc tgctacttaa gtttcctttt 543481 gaatcgagat ttgtgagcat tttgttatct ttgaacacag aaacattacc attattgctc 543541 aatacggcca tccaatcgtc tattggtgat ggcttacaga ctctgggata acaaacaggt 543601 tgtgaattta ataacccatt ctgttgcgcc agctcgaaat ccagtttatt ttcaaattct 543661 agcgggaatt ctttcacatg aaataaattc ttactgttgc aattaatgtc tttagcatat 543721 tttggctgcc caatgctaat atcaggaaat gtggtcaaat atagagtacc atcccgagcc 543781 catgttaaat tgttcttcca atcctcaaat tcctttctat ctaccaataa gtcctttaga 543841 agcttcatta tgaattgaat tggctttcct aactcctaac aaagttagtc atgctgcttt 543901 tttcattata tataattctg tctaatcatt gtttagatct cattattgag aaaagtgcgt 543961 tgcgcgtaag aaacagaata cacttaaggt gcgaaatgac ggaagaaata cgccatttaa 544021 agccttccaa tacgaagcaa aacttcaaaa gcaaatgctg ggaagttgga ttatctttgg 544081 gaaggtctat ttcctttttt attgaaataa atcattcagc taattgcata ccgtggctaa 544141 tgtcacaaca gatgtaagca acaatttaat cttacataaa tgtgttgcag ttgtggtatt 544201 tcgtaatata tacgcaatga ttctctccta ttattgaact gctatgcagg tattcgctac 544261 attgtttttc tacaggcagt cgtcgacata aataacttgt ataatcattt aagcgcatcc 544321 cagtaattaa ctattaccga acgatagagt agtcaagata ttctcttccc atcactaaca 544381 tcaagagcgc cactttttgg caattaaact agacttctgg atggcgctag cccattacct 544441 acagtactaa agattatttg cgatattctg ataaagagcc ttgaacttct cgggtgaccc 544501 ccttagcgtt tatatagcgg gagtgccaaa cgagaggaac atcaacaacc agtataacaa 544561 cgttcttgtg tagaagataa ctaaattcat ctccaaaaag aacaagagca gaacttcaat 544621 tagtaaaacc atgaatgtgc tatggattat agcactagtt ggccagctga tgcggctcgt 544681 tcagggaaca gctacctgtg ccatgtatgg gaactgtggg aaaaagtcag tatttggaaa 544741 cgaattacct tgccctgtgc cacgtagttt tgaacctcct gttctttcag atgaaacaag 544801 caaacttttg gttgaagttt gtggtgaaga gtggaaagag gtccgttatg cctgctgtac 544861 taaagatcaa gtggtagcac tgagagataa cctacaaaag gctcaacctt taatttcctc 544921 atgcccagca tgcctcaaga attttaataa cctgttctgt cacttcactt gcgctgctga 544981 ccaaggaagg tttgtcaata ttaccaaggt agaaaagtca aaagaagata aagatattgt 545041 tgcggaatta gacgttttca tgaattcgtc ttgggcatct gaattttatg actcatgtaa 545101 gaatattaaa ttttctgcta ccaacggtta tgcgatggac ctaatcggag gtggtgctaa 545161 aaattacagt caattcttga agtttttggg ggatgctaaa cctatgcttg gtggatcccc 545221 ctttcagatt aattacaagt atgatttagc aaatgaagaa aaagaatggc aggaatttaa 545281 tgatgaggtt tatgcttgcg atgatgctca atataaatgt gcgtgttctg attgtcaaga 545341 gtcttgcccc catttaaaac ctttaaaaga tggcgtgtgt aaagttggcc ctctgccatg 545401 tttttccctt tctgttctga tcttttacac aatctgtgca ctttttgcat ttatgtggta 545461 ttatctctgt aaaagaaaaa aaaacggggc aatgattgtg gacgacgata ttgttccaga 545521 atcaggttcc ttagatgaat cagagacgaa tgtattcgaa agtttcaata atgaaactaa 545581 cttttttaat ggtaaactcg ctaacctatt tacgaaagtg ggacaatttt ccgttgaaaa 545641 cccctacaag atattaataa ccactgtttt tagtatcttt gtattcagtt tcatcatatt 545701 tcagtacgct actcttgaaa cagatccaat taatttgtgg gtgagtaaaa attctgaaaa 545761 attcaaagaa aaagagtact tcgatgataa ttttgggcca ttttacagga cagagcaaat 545821 atttgttgtg aatgagacag gccctgtgtt atcatatgag acacttcact ggtggtttga 545881 cgttgaaaat tttattacgg aagagctaca atcgtcagaa aatattggat accaagatct 545941 ctgcttcaga ccaacagaag attctacatg cgtaatagag tcttttactc agtattttca 546001 gggggcctta ccaaacaagg atagctggaa aagggaactg caggaatgtg ggaaatttcc 546061 tgtaaactgt ctacctactt tccagcaacc tctaaaaact aatcttcttt tcagtgacga 546121 tgatattctc aatgcgcatg cgtttgttgt aacacttcta ttgaccaacc acactcaatc 546181 agctaatcgc tgggaagaaa gattggaaga gtatttattg gatttaaagg tccccgaggg 546241 cctgaggatc agttttaata ccgaaatatc cttggaaaaa gagcttaata ataataatga 546301 tatctcgacc gttgcaatat catacctgat gatgttttta tatgctacat gggccttgag 546361 gagaaaggat gggaaaacta ggttgttact tggaatatct ggtttactca tagttttggc 546421 ttctattgtt tgtgcagccg gatttttaac tctttttggt ttgaagtcga cattgatcat 546481 agcagaagta ataccgtttc taattttagc aataggaata gataatattt tcttgattac 546541 acatgagtat gatagaaatt gcgagcaaaa accggagtat tcaattgatc aaaaaataat 546601 aagcgctatc gggagaatgt ctccttccat tttaatgtca ttgctatgtc aaaccggatg 546661 cttcttgata gctgcatttg ttacaatgcc agctgtccat aattttgcta tatattccac 546721 agtttctgtt atattcaacg gagtattaca gctaacagcg tatgtgtcca ttttgtctct 546781 ctacgaaaag agatccaatt ataaacaaat taccggaaat gaagaaacta aggaatcatt 546841 tttgaaaacg ttttatttta agatgttaac gcaaaagagg ctcataatca ttatcttctc 546901 ggcttggttt ttcacatctc tggttttctt accagaaatt caatttgggc tagatcaaac 546961 attggctgtt ccacaggatt cctacctggt tgactatttt aaggatgttt atagcttcct 547021 aaacgtagga ccaccggttt acatggtcgt gaagaattta gatttgacta aaagacaaaa 547081 ccaacagaaa atatgtggta aatttacaac ttgcgaaaga gactcattag ctaatgtact 547141 ggagcaagaa agacacaggt caacaattac ggagccattg gctaattggc tggacgatta 547201 tttcatgttt ttaaatcctc aaaacgacca gtgttgtaga ttaaagaagg gaacagatga 547261 ggtttgtcct ccctcttttc caagtagacg ttgtgaaact tgtttccagc agggttcttg 547321 gaattacaac atgtcagggt ttcctgaggg caaggacttc atggaatacc taagcatatg 547381 gattaatgcg cctagtgacc cctgccctct aggtggtcgt gcgccatatt cgactgcgtt 547441 agtttataat gaaacgagtg tgtctgcgtc agttttcaga acagctcatc atcctttgag 547501 atcccaaaag gactttatcc aggcgtatag tgatggagtt aggatatcaa gttctttccc 547561 cgaactagat atgtttgcat actcgccgtt ttacattttt tttgttcaat atcaaacttt 547621 gggaccattg acgttgaagc taatagggag tgccattatc ctaatttttt tcatttcatc 547681 tgttttcttg cagaatatac gcagctcatt cttactggct ttggtcgtta ccatgattat 547741 cgtagatatt ggtgctttga tggccctact aggtatctca ctcaacgctg tcagtttagt 547801 caatttaatt atttgtgtcg gtttgggtgt cgagttttgt gttcatattg ttagatcatt 547861 tacagtggtc cccagtgaaa ccaagaaaga cgcaaactca agagttctct attccttgaa 547921 taccataggt gagtccgtca tcaaaggtat aactctaacc aaattcattg gagtttgtgt 547981 acttgcattc gcccaatcga aaatatttga tgtattttac tttagaatgt ggtttacact 548041 aatcattgta gcagcattgc atgctctcct atttttacct gctttacttt cattgtttgg 548101 tggtgaaagc tatagggacg attccatcga agcagaagat tagccatagc agattatact 548161 atattttacg tagtgaaaaa ataggtaaaa attcgttaat tattctgatg ccacaccaga 548221 aaatctgtgg gaaaattttt cgagtcagaa atgataacac taacacaggc ttcgttgtta 548281 tcgtgcattg aagttagata cttctactat atttaatctt taatagtgtc ataaaagtat 548341 tattggtttc gggcgaaaat cgtcattttc gcacacagaa cttcaaaaga ggaaaggcca 548401 aaagaactaa aaccgattac ttcggggtga ttttgttctg gcatcttctg gcactcttgg 548461 gcatccttag ccatttagta tatttatgaa tacattaagg tgtttgacac aagcactatc 548521 caaaagtggg agagaagctc caaaactata tcagaaagta atatttccag gcctgttcag 548581 agagggtata ccaattgcaa atgtcaagaa agttgatgaa aaaataatag atagcccaac 548641 atcaacgtca gttaatggag aggcaaaaaa aatagtacgg catggtgtga agtatgaaag 548701 ggagcaagtt aaggaatacc tttcaagcct gccgacttta acgctttcta ggaaacaaat 548761 tagggatgac tatgatgagg aacgtgcaaa acgaatgtat atgttctcta aacaaacgaa 548821 ttcctcgaat aaattccaga aacttcttac agcaaagtct caagagttta ctagagaact 548881 attgacgcta ctgatagatt gcacatcgaa tgagaagaat tcagggccag aacgcttcac 548941 tcgtaagttt cttaagttta gtaatgacga gatccctcct ctccctgact tttcaaagaa 549001 ccctcaattg tttgaaaatt atattggaat actaagtcat acaaagttca attttcgttc 549061 atcttccaaa ctaaatggta ttgtgcgtaa gatgctgcgg cacctacttc atccaaccaa 549121 taagacgact ctgccgttgc gttctgctca agtttataat gactcaatat actttttcag 549181 tgagcacttc gactttgcgt cttgtagaga aatatttgca caaatgaagg ctgaggggac 549241 taaaccaaat acaatcactt ttaatctttt actgcgtaat gtagtgaaaa actcgcatat 549301 tagaaaaacg aagcaccctg acgatgaggt ccttttttat cttagaagta tgcgtaatca 549361 tggagttttt gcagatgtaa taacttggac gacatgttat aactttcttc gtgatgaagt 549421 ttcgagacaa ttgtacattg ttcaaatggg tgaacattta ggaaatttta acgtaaattt 549481 tgtttatact gtgctaagga acggagatta tagagcagag gactgtttaa aagttttagc 549541 agcaaattca ctaccgattt cccgtaagac gttctatctg tgcatagaac gactactaaa 549601 cgaggaacaa cttgaaaccg catctaaatt acttgactat ggttttcagc acttgaaaag 549661 taattttaag ttggactcgg aggcaatgaa tcatttcatg cgggtatttg ctaataaggg 549721 aagaagtgat ttggcattcc tttgctataa tacttgtcgt aagatttaca aaattaaacc 549781 tgattctcag acgttcgaaa tgttatttaa agcgttagtt aggaatggca acaccaagaa 549841 ttttggggca gtcctacagt atatcaaaga cttaaaggtt agtgaaggat ttggattgcg 549901 gacaagttat tggagaacca aagcagactc aattttcaaa tttggtagtc ctaatacgct 549961 atcagaaaag tcaattgaaa aagcaagaaa attgttgggc aacctgattg cttccgaggg 550021 tgagttctct tggaaaattt ggaaagaaag tgattcttca caaaaaaaaa tactacgttt 550081 tttgggttgt atccccacta ctttacgctg caccaataca gcacaagatc atcagaagcc 550141 cacaaaccta ccctcaaaca tttcccagaa aaaaagagaa tatcgaaatc gggttaaagc 550201 aatagccaca aaggctgctt tggaaaaaag aatggcgtat atcaaagaca atgatgtagc 550261 tttcaaaaaa gagctagtaa agaggagaat agttggggag gtttgatgag ggaggcataa 550321 gtgccctggc atttggacag gaattttatt aatataggca tttttattgt acatatatac 550381 ttcatagatc atattcattt aattagactt cgaaaagttg aatctcttac ggcaaaggag 550441 aacaagagaa aggttaatta ttaggtctta taaaatttgt tcaattaatt ataaaggtga 550501 ttacaatacc ggaatattgg ccgaacaata cttgaaccaa attcagatga aattaataat 550561 aggtagacac gagctggtga aaaacaagca caatatagaa aggttcgaat atattaatta 550621 ttagaaaaaa ctcagatgtt ttcagaaccg gaggtatgac cgttttgact aacatgatga 550681 tcggcctcat gggcttcatc atctacagga acttcagtag tccattcaac ttcctcttct 550741 tcgactactt gaccggggat atctccattt tggatttcag gttcttcttc ttcttcacca 550801 tcttcgtctt catagacgtc atcaacggtc tgatgaaatg aaagagttgg tttgactgca 550861 gccatgtcta gggtccaaga ttccaaggcc gattcagcat ccataataat ttggcgagaa 550921 gcttcatagc catcgtacgc tggtctagct tcacctggag tgacaggaga gtcatctagc 550981 agctccaata aggcctttcc gtatccagca atcagggcaa atttttcaga aagctctctt 551041 aatgaatcaa acatataact ataagcagcc tttaattttt cacgtgtgat attcgataat 551101 tgagcctccg caaccaaaga ttcagcttcg gcacgaacta gttcttgctc taaaactggg 551161 atttttgttg attgaggatc tttatatttc aaatgggcaa tttcatctgt gatcttttcc 551221 ttacgatctc tcgaaggttg aacagaggct tcaatgttcc taattgattt taatgtgact 551281 ctgtattgat catatttatc gatgaactgg tcctgtagtt cacccaactc atatattaag 551341 acgcctaatt tgtcggttac gtcggaaaca tcatcatcat tgtcagcacc ccatagagac 551401 agttgctttg cagcttcacg gcgttcgctg gcaacaactt ccatagctct aaggacacct 551461 ttttcagtct taaccaattg agataattta cgagccaact ctggcccaaa gttaccagcc 551521 gcattttttc taaaactaga cgcaatagag gcctttccga agaacttgga cttcgttgag 551581 gatggtggtg gtggaggagc ttgtagctca gcagccgttg gagctctttg atttcttaaa 551641 gagtaagttc tgtgcattct tgtgttggag ctttgaaagt ttaatctttc gtataccaaa 551701 taaagagaat ttacggtcaa gcattggaat tgaggaaaga ggttaactga tttttttctt 551761 ttctatctca cctgtttata tattgcgatt tagccgttgc atcttcccgg tttttccgtc 551821 ttttttttaa agggcccctt tttatcccct ctaacgcctt tcgcaatccc cttttcactc 551881 ggctgcaacg agcggggttg taagagctaa gctttctagc ctagcaatga aatagaagga 551941 caagtcagac gattgacgtc aaaaaaatga gtcgcctctc tttctttctt aggccaacta 552001 gacagccgta gatgaaaata tggaaagata tgatagacag ctgagactat ggggagcatt 552061 gggccaagat agtttgaacc ggtcccgtgt gtgcgtggta ggacctgcta cacctttgct 552121 gcaggaagtt tttaagaatc tggtgcttgc cggaatatca tctcttactt ggctcaaagt 552181 agagtgtgca gttcaatcgg gttctctgtt tttagcagag cttaaaaaag atcttgagcc 552241 attggcttct aaacagctag aatatgagga aaatgacctt agaaagacgt tacagcaacc 552301 tcagtatgat tggacccgct tctcggtggt gatcttgact tgtattggtg agcaaactgc 552361 gatgctcgat ttaaatgaga ttaggcggca gagaggaaca aagtttccgc ctgttctaaa 552421 cactttcgtc tctggatttt atggatatat atatctggta ctctcagaaa cacattttgt 552481 tttgcaagca cacccagata gtaagaagta tgatttacgg ttacagaacc cttggcctga 552541 actaataaat tacgtagata catttgacct aagtaaaatg gatacagcca cgttttctgg 552601 tattccatat actgttttgc tcatgaagtg tattgcaaaa cttgaaaggg atggtaataa 552661 tgggaggata acgattgatc agatgaagaa agttttagac caaatttgcc ttcctttagg 552721 gaatgatgtt atctacgaac ccaattatgt ggaagctaaa cgctatgctt acttggcctg 552781 ctctcaaaat gattgttgta aagaactgga agatctgctc cgaaatttgg aaatatcaga 552841 ttatgggaac gattggcatg atacttataa ctacgagatt ctcacactat tattgacttt 552901 gaaaaatatt gctaaagaga atggggagct cagctttcaa cctttaacgg gcactctccc 552961 agatatggag tcaacaacgg aaaattatat cagactcaag aaactgtatg aagtaaaagc 553021 aaagcttgac aagtctcgtg tggaggaaag tttggctcgc agtaaaaaaa tagtttcaca 553081 ggatgtcttg gagacatttt gttctcatta cggggaggtc aggaaaatat tgccgccaaa 553141 aagtgacttg ttaggtattt ttagcacctc gaatgccctt ttagatgcat tagttatggt 553201 ccaattctgg gagcaaccgg cagtaactgc agaggataaa gatgagttta ttggtttacg 553261 agtcgacgat aactattccg taatggcctt ttttggaggt gcagtggttc aagaggctat 553321 aaagcttatc acacaccatt acgttcctat tgataaccta tttttatata atggcattaa 553381 taattcatcc gcaacatata aaatataaaa ttttttcgtc agctctccga gttcatagaa 553441 tgcttatttt attgtacttc cctggtttgc gttgatgcaa ataaagacta aatgtaaact 553501 tttatgatgc atatgatatc gaatgtttac aacaacgaga gatcaccggt aagaactgtg 553561 ctcaataaaa tacaacatcg ataaatactt aacgctcatc caccattcct gttcaagtca 553621 actatctcac agttgcctcg taatccaaga gggatcccaa tacaacgcct ctgcaccacc 553681 ttgataatca atccacaata aaccgttagc gaccatttca tcaagagcag atttactcct 553741 aacagcctcc catcccaagt ttgcctttaa taaagagata cttgagtagc ccagaattga 553801 gcatatttcc aaaatctttg tttgatctga tgtcaactca tttggaacac ttcgtaaaaa 553861 ctttttgccg cgaatttgaa atatctcaaa acactctagg ctctttagca tgtcgataga 553921 tttttccaaa tcatcgagtc caacattcag cttacgaaaa tgcaccttct ccaactcttg 553981 aaaagaaatg acgcctccat tcatatcttt agtttgccga caaatttcta taactttaag 554041 acatacttca taataaaaat cattcactgt aaataagtgc ttatctcgat caaataaaga 554101 taggggatca atcccaatag atgagcacat atgcatgaat tttgagcgga attcaggtga 554161 agcttgaagc tcgctattgt gtttcttggc aaattctacc agtcgttctt ggaataccat 554221 taattggtcc cttagttcga cagattgctt ttcaagtatg gttttgttta cgtcattgta 554281 ctttccatcc ttcaactcgt caaaggctgc cagtccaaac tgtttcatgt tagtgagttt 554341 cgaagttggc tgttacgcca agcattttca agtcgtggta aagtctttgg tctactgcat 554401 cgcctcaaaa ggttataata tatcccagaa ttgatggatt aagttcttga aatagcacac 554461 cgttataagt gataaatata ttgtcttcga ataacgaatt tattagattt ctatgtattt 554521 ctacttgaag ttaggaatag atctttctgg aattgttttc agcaaaatta tgcttaagct 554581 ataactatag tgagaatcaa gaatatgtct gccaatgatt tcaagcctga aacgtggact 554641 tcaagcgcca acgaagcctt aagagtttct atagttggag aaaacgctgt tcagttttca 554701 ccattattca cgtatccaat ttacggtgac tccgaaaaga tctacggcta taaggatctc 554761 atcatccacc tagcatttga ttcagtaaca ttcaagccgt atgttaacgt caagtattca 554821 gcaaaattag gagacgacaa tattgtagac gtggaaaaaa aattactctc atttctacca 554881 aaggatgatg taattgttag ggatgaagct aaatgggtag attgctttgc agaagaacga 554941 aaaacacata atttatctga tgtttttgaa aaagtatcag agtattcgtt gaatggggaa 555001 gaatttgttg tatataaatc gagtttggtt gacgattttg ccaggagaat gcatcgtcgt 555061 gttcaaatct tttcattact ttttatcgaa gccgctaact atatagatga gactgacccg 555121 agttggcaaa tctattggtt gttgaacaag aaaacaaaag aattgattgg tttcgtcact 555181 acttacaagt attggcacta ccttggagca aaatctttcg atgaggatat agataaaaaa 555241 ttcagagcca aaatatctca atttctgatc tttccacctt atcaaaataa aggccacgga 555301 tcctgtcttt atgaggctat aatccaatct tggctagaag acaaaagtat tactgaaatt 555361 actgtagagg atccaaacga agcatttgac gatcttcgcg acaggaatga tattcaaaga 555421 ctgcgaaaac ttggttatga tgctgtcttt cagaagcact ccgacctttc tgatgagttt 555481 ttggagtcaa gccgaaaatc tttaaaactg gaagaaagac agtttaatcg tcttgtggaa 555541 atgcttcttc ttttaaacaa ttctccatca tttgaattaa aggtaaagaa taggttgtac 555601 attaaaaatt atgatgccct agatcaaact gatccagaaa aggcaagaga agctttacaa 555661 aattcattta ttttagtcaa agatgattat aggcgtatta tagagtcgat aaataaatct 555721 caaggttaac tgtttattaa atatataata acatatttat ttgtttaaca agcctgaaat 555781 aagaaattct tttataaata catcatcgag atgatcatca aagtgtctct atagttaata 555841 taagcttatg caaaggttga agccgttatg ttgtcgtaat tctaaattac aggttatatt 555901 aaagagatta tcttgactga tataaaattt cttatcatgg tagtgatcac aaatagatca 555961 catgatatat tttttatttt taattttttt taattataaa aataattttt ttctttaaat 556021 taaacaaaaa taaaaaattg ttttttgttg gttaagattt ccgaaaatag aaatattatt 556081 cagttgaaag acaaaaaaac ataaatattt ctatgagcaa acaatttgaa cagaaaaata 556141 aaattgggga agtgacacac catggtagcg gttctaaagc gaaatcggca aagcggctaa 556201 atagcagttt tgatgactta ctccacactg aaaatggatg accttaaata ggagataaag 556261 ctttttcatc cctatgtatt taagatgact ggcttgtcaa gcattctaat cataaaaaaa 556321 agatcgtatt tgatcaagaa tttatacata gacgccgcta aataattgaa tacaaaatgg 556381 tacaaaggct tctaccgggc gcacatatat gcagaaggtc cttcaattcg tctgcaatta 556441 taaagtcttc tgcattgact ctcaaggaag cattagaaaa cgtgatacct aagaaaagag 556501 atgctgtgaa gaaattgaag gcctgttatg gcagcacgtt tgtcggaccg attaccattt 556561 catcagttct aggtgggatg agaggtaatc agtcaatgtt ttggcaagga acatcattag 556621 atcccgaaca tggcattaaa tttcaaggtt taacgattga agaatgtcaa aatagattac 556681 ctaatacagg tattgatggc gataatttcc tgccagaatc aatgttatgg ctgttgatga 556741 caggtggtgt gccaactttc cagcaagctg cttctttcag gaaagaattg gctattcgtg 556801 gaaggaaatt gccacattat acagagaaag ttttgtcaag tttacccaaa gatatgcacc 556861 ctatgaccca acttgcaatt ggtttagcat caatgaacaa aggatccctc tttgctacaa 556921 actaccaaaa gggcctcata ggaaagatgg aattttggaa agatactctt gaagattcgc 556981 taaatttaat tgcttcactc ccgctgctga ctgggagaat ttattcgaac attacaaatg 557041 agggacaccc attaggtcaa tatagtgagg aggtggattg gtgtacaaac atatgttccc 557101 tgctcggcat gacaaatgga acgaactctt ctaatacatg caaccttact tcccagcaat 557161 ccctggactt cataaacttg atgcggttat ataccggtat acatgtagac catgaaggtg 557221 gtaatgtttc tgctcacacc acccacttgg ttggaagtgc gttgagtgac ccgtatctca 557281 gctattcatc tggaataatg ggattagcgg gtcctttgca tgggttagca gcacaagaag 557341 tagtaaggtt tctcatagag atgaactcta atatttccag cattgcacga gaacaagaaa 557401 tcaaagatta tctttggaaa attttgaatt caaaccgtgt gatccccggt tatgggcacg 557461 cagttttgcg taaaccggat cctcgattta cagcaatgct tgaatttgcg caaaagaggc 557521 ctattgaatt tgagaacgac aagaacgttt tgttgatgca aaaattggca gaaatagcgc 557581 ctaaggtttt gttggaacac ggaaagagta agaatccatt tcccaatgtt gactctgcat 557641 cggggatttt gttttatcat tatggaatca gggaattatt attctttacc gtcatttttg 557701 ggtgttcaag ggccatggga cccttgacac aacttgtttg ggatcgcatt ctaggtttac 557761 caattgaaag gcccaagagt ttgaacttgg agggtctgga agcacttacc aaagcaagca 557821 atgttaacaa gttgtaacgc agttccaatt tacaagaatg cttcgtttgc tattacaata 557881 ttgaaatata aataaaattc catacagcat gtctaatcat agctaattta tacatattca 557941 tcatgaaaac atatagggga aaatatggtc ggttaacaca cctatcaaaa aattattcag 558001 caattccaat ctcgttagta aaatatattc ttattttttt tttttttctc tgattgtatt 558061 atttctggag ttttgactta tttttttacc acatcgcgct tttcgtcccc aatctctctg 558121 atatatgatg ctgtctatag gtagccactt ccccgatgtc ggacctcggg ccgtttacaa 558181 actttattga gatgacctta tttctccaca ttctagtcat tcaactttta ccctcatatg 558241 tttaccttca ctaatgtgaa agcatgacca aagaaagtgt ataaggtata taaatctgcc 558301 ataatgtatg tataacttat taggactttc tcaaatagta ttttggtatt ttctactgtt 558361 ctctgatgat cgagagcaaa cagaatgttt ttagccaaaa atctaaaaaa taataaaatc 558421 aaggtatgct tgcctaaaaa gaaatttgct gcgctgagta cagcgtctat acaaactaat 558481 gaaagaccaa atccagataa ggttttgaag gacatcgcga aatatgtcca tgaaacccca 558541 ttaaaatcat ctttggctct agatacagca cgactctgtt tccttgatac tctaggctgt 558601 ggcttggcgg ctttgaaatt taagcaggct caaaatatta ttaaaccaat tgtgccagga 558661 acaatagttc ccagtggaac aaaaatattg ggcacatctt acgttatgga tccagtgaag 558721 ggagcttttg ccattggtac tctaatacgt tggttagatt acaatgactg ctggttagct 558781 gccgagtggg ggcacccatc agataacctt gggggaattt tagctgtcgc ggatcacttg 558841 tccagattaa acaaggctac ccacggaaag aatggaaaac agtttcttgt taaagacgta 558901 ttagaggcaa tgattaaagc gcatgaaatc caaggtatta tagcgctcga aaattctttc 558961 aataaagtag gtttagatca tgtggtactc gtgaaagtag caacggctgg tgttgtctcg 559021 aagatgctgg gcctgagcca ggaacaaact attgaagcat tgtcacaagc atttgtagac 559081 ggtcaatcac tgcgtactta ccgtcatgcc ccaaatactg gatctagaaa gtcgtgggcg 559141 gcgggagatg cagtttcgag ggctgtaaac ttggcttatt tagtcaaaaa tgctaatgtt 559201 ggcacgatac cttcagtatt aacagctaga acctggggat tttatgacgt tttatttaag 559261 ggtaaacctt tttcattcca acaaagatca aaatatgatt cctacgtcat ggaaaacgtt 559321 ctgttcaaga tatcatttcc tgccgaattc catgcgcaaa ctgctgtaga agctgctgta 559381 aaagcatata ggattcttgc caaacaaggg aaaactttta aagatattaa atcgatcaga 559441 attagaactc aagaggcggc aatgaggatt atagataaat ccggtcctct gtataattat 559501 gccgataggg atcattgtat ccagtacatg atcgcggttc cgctgattac tggtaatctc 559561 acagctactg attattcgga tgaggtcgca agaaatcctg agatcgataa cttgagatcg 559621 aaaatgtact gtatcgaaga tactcatctc actcaaaact atcacgatcc tgataaaagg 559681 tcgataggaa acgctcttct catagagctg aacgatggga cgcagttgga tgaaattttt 559741 gtagagtacc ctgttggtca caaatttaga cgagaggaag gaataccatt actaatgaat 559801 aaatttcaaa ggcatctgcg cgaacatttt gtagagagcc ctgataaagt cgaccttata 559861 atgaaggtaa gttcaaaaac aaactttttg aatatgcaaa tcgacaaata catggatttg 559921 tttactgagg gatgaatggt tggctcttta agagcgaacg gcatggtacc tacttcaatt 559981 tttaaagaca aaaggcgccg tttcgataaa caagaaatca ctttcaaaac ataattaaac 560041 caaagaacat gcggttttct aattatgctg gcttaatttt actggtattt atctacataa 560101 taataactat taaaaaatta aataattggc tctatttatt tttctttctt caacttgcaa 560161 gagttcgtca attcatggaa aaatacaaaa atagaaatgc gaattctgtg gatcgaacac 560221 aggacctcca gataacttga ccgaagtttt ttcttcagtc tggcgctctc ccaactgagc 560281 taaatccgct caatttctat gctctaacca ccttagctaa aaactcaata caggattagt 560341 tgataaatgg gtgttatcaa ctcaatccac agtgttggaa tcagagtcag ttatcatctt 560401 tgggctagta ttattgtaag tgttggaata aaaattctaa aatatcatcc atttagtagt 560461 gttcatatta ctaatatatc tgttggaata aaaatccact atcgtctatc aactaatagt 560521 tatattatca atatattatc atatacggtg ttaagatgat gacataagtt atgagaagct 560581 gtcatcgagg ttagaggaag ctgaagtgca aggattgata atgtaatagg ataatgaaac 560641 atataaaacg gaatgaggaa tattcgtaat attagtatgt agaaatatag attccatttt 560701 gaggattcct atatcctcga ggagaacttc tagtatattc tgtataccta atattatagc 560761 cttcatcaac aatggaatcc caacaattat ctcaacattc acccatttct caatatcatc 560821 acgtgcggtc taagaagatg atatgaagat tgagaatagt catcaggtgt aatggaagct 560881 aattgcaagg attggtaatt tagtaggatg atgaatgaca gtcacataag atgaaaagga 560941 aaacaataat gccattatat cgagaatatc gatctcttcg tggattcttc tcatagagaa 561001 attctagtat aatatatata cgaaatatta tggcctttaa caacaataaa attccaacaa 561061 ttatcaacta attcgaacat ctcttgacaa tatacattat taatttttac atttcgactt 561121 tctttgaatt agggactgtc tctcaattca tctctttctc atacagaata tcacttatcc 561181 tatataactt atataagatt agaatctaac tagagcgagg agagcggaaa ctcggatcaa 561241 aagtgattgt ttaagtgttt gtgcgtttgt gcggctcatt aagacaataa ggttttgctt 561301 ttgtattcaa ttttgtgggt tttataacgt ataaatgcgc ttcttgaaag cttgttaacg 561361 attttatcgt aaagaaataa ataaactaaa gaattgagga gacaatactg ttttgataaa 561421 taagccccaa aaatattata gggccgcaag gaataaattt cataatgcgc atatgcccag 561481 actcctctgt ttctttcgaa gttttacact agacttgaat taaataaagt attggacata 561541 aaactctccg aatcattgtt cgggacgttg ttccctttaa ttttcatttt ctcaatttca 561601 taaagagccg catcaatgct atcgaagtac ggagaatatg tctctcctgc atcactaaat 561661 gtgttgctag tattattttc gttgttattt gcttgcgctc tttccacact agcagctaca 561721 cctgctttga ataatcgcct tcttactttg tcatttatag atacattgac aaggtaaata 561781 aagacattgc gcctcttgta actagtgata atttcctcca gcacttgggc ggctgaagaa 561841 tctattgagg tcatcccacc taaatcgaaa atgacatatt ttatggaatc cttcgagcga 561901 agtgatttcc ttccaggatg tatcttagac gaaccgtacc tctctattct gtcaagtctc 561961 tgttttaaat cttcgctgtt tgtaaatgtg agaggctcag gtattctaac aatcatgcat 562021 ccctcgattt cttctgtgcc ctcaacatcc agagagttcc ttttcatgtt catcatgtag 562081 tcgtcaagat tcgtaaagtt cgacgttccc gctaccctag ccagaatttg gattcttgac 562141 tttgctgaat gctttataat atttataatt gaatagacac atccgatgca tattcctgct 562201 tcgattgagt aaaatattgt agtgcagaag gtaacagcaa aaacaaatag ttcactaaag 562261 ccaccacatc gcaaatggaa ctttatgtcg cctggcactt cctctaataa actaattccg 562321 atgatggttg ttatgacgga taaaacacaa ttaggaatat aatgtacgaa ttgaagaagt 562381 aaattcattg tgattagggt gatgacaccc ataaacactc ccgacattac gctttgtgct 562441 cctgataggg cgttgatctt ggatcttcca tatccgccga atgcgggaag agcaccgaat 562501 aatgagatga caatattcat gaatcctaaa gctactagtt ctctattaga ggaaacggta 562561 agattgtaag ttgttccaag agatttcgac gcggtcgtag attcaaaaaa acccaacatt 562621 gccactatta gagatgcact aaaaagatct ggtattagct tacgtctagg acgagttaaa 562681 gggtttttca attcatcaaa attgtccatg ctaaagtcgc caatgataga aataccatat 562741 ctgtgtttta aattaaattt catggaaata agaatagtaa caattaccac caataatata 562801 tctggaaaaa atattgcgct cttgtgatat ttcattaatt tcctctttag tagacgcgtt 562861 aaaaagagga caatcaagca acatccgctg aatattgccg ttggtatatg gtattgtgct 562921 ggtgcataat caatgaggaa aagtattttc tcgaaagggg tatggtagtg ttgaggcaag 562981 cttactaaaa atttgtctag ctttaattca gaaatcaaag agttgattat cataaccagt 563041 cctactgaac ttatgaaacc tcgtagaagt gccttgctaa gaacatttcc aaggaaacca 563101 aatctggaaa taccagaaaa aagtaggata gtgccactaa caaatgttat tactgttgaa 563161 atatcaatta gagaaacatt ttctttatgt agtgttatag attcgactgc ttgtcccacg 563221 accaaggaaa ttgcactttc gggcccaact atcatctgag gaacagaacc taaaatacca 563281 tagacaaatg ggctaatagc caaagaatat agtccgcata aaggtgggac atgtgcaatt 563341 gaagttgtgt acgatagcgc aagtggtatc tgaaatgacg ctactgagat acctgcgatt 563401 acgtcgcccc acagtttatt gaaagtgtac tcaggaagcc atgaaaagca gggcaggtaa 563461 taaggtaaag tttcaaacac tgtattctca tcaacgctat cattattgtt cgtattactt 563521 gtattacttg tattatttgt attatttgta ttattggtgc atcctgatct tgagttgttg 563581 ggtgggggta ccccagtagt tgaattagat gctgcaatat aggtcctgcc tcgattggat 563641 gaatccttat cataatcaaa attgtccgag aaagtgtcac gctggtcgac tgatcttttg 563701 aatcttggtg gagcggtaga ggaatatgac atccttccac gccccaataa cgaattattt 563761 gatgtcatcc tataattgtt tccgtaagtt cttggaaatc actaggaagt ttgtggagtt 563821 attgttctcc tcatattctc ccatctggaa gaactctatt attcctttgc catttctcgt 563881 agtcttttat atttagtccg ctttacaccg aaaaggtcat ttttaaaaag gcaagagaac 563941 taggaaaagt aaaacgtgcc cccttcaaag cgaagagatg aatatattta gaagttaaga 564001 atttatttat ttatatttac caagtttttc agttagttca gggactattt tgtaaagatc 564061 cccttgcaac ccatagtcag cgacattaaa tataggggca tcaggatcat tgttaatggc 564121 aacgataact ttcgaatcct tcattcccgc taaatgctga actgcaccag aaacgccaat 564181 ggctatatac aaatttggtg cgactacctt accagtctga ccgatttgta gagaattatc 564241 acatagtcca ttatcaacag aagctcttgt ggcacctata gcagcgtgca aaacatctgc 564301 tagcggcgat aatagcttct caaatgtctc cttatccttg agtgcccttc caccagttac 564361 cacgttctgt gcagaagtaa gttcaggcct ttcactcttg gtaagaatag ttttaaccca 564421 ggtaacattt aagtcacaag gaggaatatc agttctcttc tcaatggtaa cagaatccat 564481 actaccctct gcaattggtg gaaaagctga tgccctaata atcaacagtt ttttttctgc 564541 ctggcattct attgtagaaa taatgttacc tgcataaatt ggccttataa aggtcttagg 564601 atctttgatt acagtaacct cacaaacagg ttggacgtcc aagagcgcac ccacccgagg 564661 taaaacactt tttccaacag aggagtttga gacaacaaaa tgtgaatagt cgccgccttt 564721 taatagtttc actaataacg gagttagttg ttcgggaaga caggtatcta attttgaatc 564781 ttcaaatatg acaagctttt ctaaattgct gcatgaatat gaagatttta gcgcctcagc 564841 agttttttca gctttgctac ctgtgattac agctgtgata gggttagaca acttttgtgc 564901 agcagccaat aaactcaatg atgaccttga aacagagcca tcttttgagc tttcaatgaa 564961 agctaaagtg gaggcgtaat ttttctggag gaactttgcc ttgctagctc taggcaagac 565021 agcagccaat gatttaaaca tagaaattaa caattagctg ctttaccgtt aatggtagta 565081 aattatatca ctagattttg tttgttgatt attttaattg tttttaattt ttagttagta 565141 gattttcgtt cgaggcccta aaaatgtacc gaaaagtcat aataaacggg cggagtcaca 565201 tcgtaagagt aacatataca atatgcgagc agactttgtc cattaagcca agtaacaaca 565261 aaagaaccaa aaaaaggaaa gtatctcgtc tctgttgagt aattcttata tcttgcaaga 565321 tttaattctc actactaata cggaactcaa tcaaagtggc ttaatcccaa gacatgcatt 565381 gaatacggta tcattggctg ttgacagttt aagaaaagta gttgtcacgt tcctgaggtt 565441 actggggaca agggaaagta gatactcgtc ttacgaaatt ggatatagtt actctctaat 565501 gctcaatcca tgtaaagcat gaatcatctc aacagaaaaa tctgggagag catatttgca 565561 acaaaagaat ccaaatatca gtatataatt atataagtga gctaagaagt gaacaaaaga 565621 aaaggaagag gggaaaaatt ttggctggac ttgtagaacg atagaacgaa agagtccaag 565681 ggggaagtaa taaagttatt gaacgaaaca acaaaaattc gatggagata ttaacaaatg 565741 catagcagcg cagctaaccg acccgaagct agtaccaacg aatttttcaa ctattctgtg 565801 ttgattgtct cctttgcaac accgagctct tcagtattct cagctgaaag ttattattga 565861 aatcacgttg gggactttca tgatctagtg gtcttggtga gtagcattta atattttgac 565921 cattgaaagg gcatctctca attggagaaa ggccactctt agggataggc gttttaacaa 565981 tctgtttatg ggatgaatga tatatttttg aggatggatt cacgatactg atatgtttcc 566041 cgtccgcatt attcggatat gtagtgcctt ctttcgataa aatagatgcc aatcctggcg 566101 tatgctttgt ttcgatgacg gagcttacca atttttcact tcgtattttc gatgagttct 566161 tatttttaca tttgacgttc aatattccga catacgtctc tctttctgaa atgttggaac 566221 tctgtggcct tggatttggt gttttttcac ccgaaaaatt gttgataact gcacttttct 566281 ttgaggtact actatttata tcttcctgct cttttgttcc ccgcttaaga tgttttggat 566341 ggcaagtttc aataaactgc ggttttattc ctgcttctga agaggtgccc gagatgtgaa 566401 cctcatttcc accactacca gtataagtaa agtagtccgt accttctttt ccaaagtcat 566461 ttgaggaata taccaaaaaa acaccttcct ttacttgaaa gcgatccacg aatgggaaag 566521 tatccccttc cgaagtcaca tctgagggaa caaattttaa aacatatgag atgttgtttt 566581 catccacggc atcataaaat ttacagcaat tattctcata catcaagttt ttgagagtgt 566641 agtcatgcaa tcctaaatct ttgaaatgca tctgatctat ttgtttctgt atttctcttt 566701 tcttgagtta tataaacgga atgattagta gtttggcaga atttatagca agtattaaat 566761 agttgaatac ctcaatattc tccataataa acgccatatc gtacataaag gctaaaacaa 566821 gaatgcctga taccgttctg ctttttgttt tatctttccc tatattttct ttcccttttg 566881 atgctttacg taatttttcc cggcatatgt gagcttccta atagactcta tttttatttt 566941 tccctttcaa agtgcgagag aaatacacac aaccagccta cgcttatttt cacccatacc 567001 gtcatacgcc atatgatata taatgtgaaa caaacgcggg gaagagcgcg acacgacagc 567061 ttagcagggg cattccacgc aacacctgaa actttaagta aaactgtttc tgcgaggata 567121 tcttggcaaa acaaacacta actttcgaac taaatatagt gatcgtggtc ataaattaat 567181 aaaaagagga taaatagaga taaaagagat atgtgactaa gttgctggca atatgtatta 567241 tttatacttt tatcttcttg aagcgtattc aaaattgcgt ttcggtaaag ctctcaccag 567301 atgtacttaa agtttgggat gaagcaccgt tttggacaac tttcattaag gaatcaacat 567361 attctgcacc agaccatagc tggtgtgtca tgatatcaca attagtctcc ttttcccgtt 567421 tttgcacttt ttcgacgtat gctttcattc cgtcactttg gaagctattg gctaattccc 567481 agaatgatac tccatctgaa tgcagaccgg caagggaaac cagttgcaac gtgaagcctt 567541 cttttgccaa gtcccatacg aaggatttta atgccttatc atcaaagccg tgagcgctcc 567601 aattgaaact aggagataag ttatatacta gcttggtagc tggaagttgt ttatgaattt 567661 ttcttgaaaa tgagcgtgcc tgctccaggt caggagtttt cgtttccagc caaatcatat 567721 cagaatatgg ggcaaacacc aaagatcttc taatagctgc ttcaatacaa ccgttaaaca 567781 tgtaatatcc ctctttggtc ctcggagcat cccagtcaaa tataattttc tttagtggtg 567841 tcacttcttg agctaaaagt ttcatttctc ttaagcttag gtatgctcta cccagcttgt 567901 ttaccataag gtcttccttc ttttctttat agctttcaaa ctcgcttgcc gtaaactgct 567961 tttctaaggc ctcttcaaat gtaaacagct cattttcatg gtaccattct ttttccatgt 568021 cagcaatggc ggagttggga atttttttgt cctccatctc aatcaatttt tcgctccaag 568081 gcaccacgtt atctcttatt atacccctaa tgaattcgtg gtctctcgga tcactgcttg 568141 aactcaacag cttaccatta caggaatctg ttcttgcaat aaccaaattt tctgtcccca 568201 tgatatccca ttgaaacctg gtggaaatca atctcataag atgtgttgct gtgggcacca 568261 aaacagcccc acttagatgg ccacaccttt tgcctcccac catctgatct tcaagatgaa 568321 taccagcagc ccctttctcc gcaaacaact tagcaacttt cattacagtc gttgggccac 568381 cgtgacccat gtctgcgtcc gcgataattg gttttaaata atcaacagga gtagaacctt 568441 tgatggaggc ctccaagaaa gcctttcgat cgtgcaattg ctgcgccttg aatattctct 568501 ccacttgatt cggcacagta tcgtatggat aatcgccaaa atccggcgat acttcatttg 568561 tagatccaac taatgtggaa gaacaagccc aaccagatat gtaagcaact ttgatatttc 568621 tgcaacgggc caactgactc atttgtacag gatcgataac tcccaacgtg tgaagtggag 568681 taccattctt gaaattctct tctagtaagt tgaacagctt tcgagcttga taagatgaag 568741 gataaattga agtattagca ggaaggctgc cccgatgctt tacaacatcc gtagctgagt 568801 atggacgact gatattctta aatctggctg attcccacca ttcttctact ttacttgatt 568861 ccgagaacac gaagtcttta gtactgcttg ccccgttgaa agatcttcgc agtgacttgt 568921 ctgatgacaa aaccagcttc ttcagtgttc ccgtagtttt tctattgaaa gttttgttgt 568981 taatcattgt aatcatcggc gaaatactag aaaagtcgaa atcgatatta ttatcggcgc 569041 tgtagcttct ttaggccact agtactttta taagctcttc aaccgcaaca aaagttaaga 569101 aataagagag ttattcttaa gcccattttt tacattatat agtgtacgta tgatatcgct 569161 agcatgatgt tagtgtttcg gcgcttctaa ttgaagagca tatccttttc ttctccaatg 569221 cacttttatt tctttccccg caagcatatt cggcccggat ctcggacttg gatcattaac 569281 ctgaggacag cggctagtaa ccgctgtcgc tcatatggaa ggagaaaata aaaattcagg 569341 catatacaat tatttcgtcc tctcttctca gtttaagatc tttagttacc gcatctgcaa 569401 caggatattc gttcaacttg accatccctt tcgtagccaa attcagtaag gataggaagg 569461 cactggcggc tatctgtctg ctgacacctc tttctacatc atcaaagtta gctcccgttt 569521 gagcttcgcc catgcggctt gggatgatgt caaccaacag catctttctc ttgaaaggcg 569581 gattggagcg cgttgttctt ccgacaacaa ttgatctttc tttgatgtaa tcgtagaatt 569641 ttttagtttg ataatccaga atgacgtctt gaaaatttgt tttgtcctgc tgcaaatttt 569701 gctgagagcc atcagaaaaa caactgttgc tggaatcgtc ttcctcggca aaattctgtt 569761 cagatggccc gactctcctt ctgagagcac caactatatc ttcattgaaa ccactagacc 569821 tggttgagtt tctggtatga cttcttccaa aacttgaagg aggtagattc aaattaaaat 569881 ctaggatgtt accttgagag ttttcttcaa tatagtgccc atcttccaaa tcctcattaa 569941 tttgttcaag gtttaaaagt aaattatcat tttccatatc ggaagaataa ttatcgttct 570001 tattattgcg aaaacttttc ctaccatatt cgtgacttct ggtactactt gagctttggg 570061 ttgatactaa agaatgtgct ctttttctcc ctctttcaac tgaactaaaa ccttggggat 570121 ataagtccca ttcgctagtc tttatattgg aaaagtcgtt aaatatactt aaccaatttg 570181 ttgaaaaaaa ttcttcctca ccacatgacc ttaccaaact acttatgtta gaggtgagaa 570241 aattttggcc ggttagtttt ctaatcctgt ttttttccat taagtgactg taatttccat 570301 ggttgaattt gagaacttca tttggataac tcgttttggc atcaaattgt accttagaaa 570361 attgcccacc tacatcggcg cgatgtcctc tttgcattct ggtgttaagt ttctgttgaa 570421 gatcgttttc ttcttcagaa gcctgcgctt ctaaccccaa ttcgtagtct ttgagattgg 570481 ctaccggccc ttcattttca actgatgtat cttctcctcc attactgtta ttttcattat 570541 cgttctcaaa attcaacacc aattcatctc cttgataatt aaacttgaaa tcgtttccat 570601 ccttctgtga acttgagtga gagcctaaag gtgtcccctg atggctcact atatcatcta 570661 agtccaggtt aaagtccaca tcaacgggaa tttcatccag cggaaaagaa tttctaacgt 570721 tagatcctag attactttgc gcgtctgagt tagtcatgtc cccatgaagc tcgaacctgt 570781 tagaattact taactcattg atgtagtctt gtctccttat tgatttagct tcctcaataa 570841 aagatacatt atcttggaga gtagtgttaa gaaactccag tgcgggaact ttagtaatat 570901 catataaggg atcgtcatcg aaaaaaacgc attcttccca ggtgtaatta ttgtttttgt 570961 ttcctataat actgttatta ctattcaatc cattaatcct cgtagactta tttttggcct 571021 taaaagcgta tacatcattt ttttgtaact gcacaagcag gtgatttagg tcattcaaca 571081 catactcggt ttttttatta tagcaaattg tcactccata taaaagatta gaaatgtatc 571141 taagagaaaa atcattttcg aaattttgaa tttcatcaca tgtttttggt atggaaatat 571201 ttacgatgtc ttttttctta acggtggatg aagatatgtt tccagtggag ttgcttttgt 571261 ttgaataata attgttactt tcctttacaa tggaatttcc caacgcagaa agcaaccaca 571321 ctgttgtgag gcccttatat ttcttgtcat ctttaaagtt caacgaaaga ggtgccattg 571381 cagaatattt gtaatattaa tctatatata gcaaatgctt tagagttgct gaggctaaaa 571441 agaaattata gaacaactat aaaatattaa gtccggatac actgcttcct ttataccatg 571501 cccttccctt tatagtgtaa aaacgcgtaa tcttaatcaa tctgatatat tggtttgccg 571561 ccgaagtcaa gttctcctgc taaaacgaga caaaaagaac acgtgaaaga agaaagaaaa 571621 acgttacgat aaaataagtt ttatacctac tttcatatct accaaaggaa cacaatgaat 571681 tgccgtatgt tattcttgaa gtaagagtca agtattattt atggactagt attcacgtta 571741 ctagtacatt atcacatgcg gtgtaagaag atgatataaa aattgaggga cagtaatcaa 571801 attcaacgga agtcaaaaag gaaggattgg taatgtataa tatcgaaaaa tgtgcgaaat 571861 agttgataat tgttggagtt ttatagttgt taaaggctat aatattacgt atttagaata 571921 tactagaatt tctctatgag aagaacccac gaagagatcg atattctcga tataatggca 571981 ttattgttat ccttttcatc ttatgtgact gtcattcatc atcctactaa attatcaatc 572041 cttgcaatta gcttctatta cacctgatga ctgtttttca atctttatgt gatcttttta 572101 cacccaatgt gataaagtac tagtaacatg aatactacta aacagatgat actttagagt 572161 tttcattcca acactcaatt gtaaaaataa gacaatatta tgattttttg gctgtataac 572221 cacatctatt tagtagcagg gtgacatgtt actcccacac aatacttcgc gcaagtggtt 572281 tagtggtaaa atccaacgtt gccatcgttg ggcccccggt tcgattccgg gcttgcgcaa 572341 tttttccccc tcgccctgaa gggcgtaacg ttaacgcttc cggtaatttg cgaataattt 572401 ttcttcccat ttcccctttc ttttcccttt aacatgtgga gcatagcagg ctctttactt 572461 ttttacgcat tcagacagtc gggaggtcaa ttggtggtgc cggttgtggg aaagaggtaa 572521 ttttatttcc tttattggac atgatttcaa tagtcacatt ggggcaggaa aaagaaaagg 572581 gagaaaaaaa ttcagtaaag aaaaaaaata agaaaaagag aaaagaaaca agagagggct 572641 acagatttct aaatatcctt ttgctgcaca ttttttattt acctgctaat tggtcttagt 572701 aatacagagt cgtgcatttc cactttataa gaaaaaaaaa agggataaca gcaccagcac 572761 ttgattgaaa actagaaagt tcacgtttta taagtccttt ccgttctctt tatcagttat 572821 aataaaagag ccaagacaaa acgtggcagg gaagcttttc caaggaaaag agggttgtaa 572881 tattaaacaa aaaccgtaat caagcaaaat aagaccccgt ggttttttat cataggaaaa 572941 gagttctctg ttgtcactct accatatttg acaagaaaaa ggaaacaaaa gtatagaaaa 573001 aaaaaaccta aaaaataatg gtcttgataa atggcataaa gtatgcctgt gagaggtgca 573061 taagaggcca tagagtaaca acatgcaatc atacagatca accgcttatg atgatcaaac 573121 ccaaaggtag accttccact acatgcgact attgtaaaca acttcgaaaa aacaagaatg 573181 caaatcctga aggtgtttgc acgtgtggcc ggctagagaa gaaaaaactg gcacagaaag 573241 ccaaagaaga agcaagagct aaagccaaag aaaaacaaag aaaacagtgt acctgcggga 573301 ctgatgaggt ttgcaaatat catgctcaaa agagacatct aagaaagtcc ccttcaagtt 573361 ctcaaaagaa aggaagatcc atttctcgtt ctcaaccaat gtttgaaagg gtattgtctt 573421 ctacttcact tgacagcaat atgttatccg gccacggagc actatcagat acctctagca 573481 tactgacgag cacattttta gacagtgagc cgggtgttgg taaaatttca aaagattacc 573541 atcatgtccc ttcattggcc tccatttcat ccttacaatc ctcgcaatcg ttagatcaaa 573601 atttcagtat accacaaagc ccgccgttat cttcaatgtc atttaatttt ctcacgggaa 573661 atatcaatga aaccaaccaa aatcacagta atcatcagca ttcaaaatca ggcaataact 573721 ggcaagatag ttcggtaagc ttgccagcga aagctgattc acgtcttaac atgatggata 573781 aaaacaactc tgtgggtctt gacctattag gccattcaaa acgaatatcg ccgatatcaa 573841 actctcgtgt gggcgaagtt agcgttccgc tagaagaata tattccttct gacattgatg 573901 gggttggaag agttactgat aaaagctctt tggtctacga ttggccattt gatgaaagta 573961 ttgagagaaa tttcagtaca accgcaaccg ctgcaactgg tgaaagtaag ttcgacatta 574021 acgacaactg taatagaatt aatagcaaaa gttatagtaa gactaatagt atgaatggaa 574081 acggtatgaa caatagcaat aataataata tcaacagtaa tggcaacgac aagaacaata 574141 acaactcttc tagacaagaa catcaaggaa atggactatt tgacatgttt acagattcat 574201 cgtcgatttc aacgctttcc cgtgcaaact tattattgca agaaaaaatt ggttcgcaag 574261 aaaactctgt caaacaagaa aactattcga aaaatcctca acttcgtcat caattaactt 574321 ccagaagtag atcatttatt catcatccgg caaacgagta tttgaagaat acttttggaa 574381 attcacatag taatgacatc ggaaagggag ttgaagtgct atctttgaca ccgagtttta 574441 tggatattcc cgaaaaagaa agagaaacgg aaagatcgcc atcatccaat tacattactg 574501 acagaccttt cactcgaaaa cctagatctt ctagcattga cgtaaaccat aggtatccac 574561 ctatggcacc aacaaccgta gcgacatctc ccggtgcatt gaacaatgcc gtagcaagca 574621 atctcgacga tcaactgagt ttaacatcac taaactctca gccatcatcg atagcaaata 574681 tgatgatgga cccttcaaac ctagctgagc aaagttctat tcattcagtt cctcagtcaa 574741 taaactctcc gagaatgcct aaaactggaa gtcgccaaga caagaacatt cacactaaga 574801 aggaagaaag aaatccgcta aataacatac acgatctgtc acaattggaa aatgtaccag 574861 acgagatgaa ccaaatgttc tccccaccat taaaaagtat gaatagaccg gatgccataa 574921 gggaaaattc atctagtagt aatttcataa tccaaggaaa tagcatgatc tctacgcctt 574981 ccggaaggaa tgaccttcca gatacctctc caatgagtag tattcaaaca gcgtcaccac 575041 caagtcaatt actgaccgat caaggatttg cggatttgga taatttcatg tcttcgttat 575101 gataaatttg cttttcgtct cttgcttctc tgtaactgta gttttcctcc tcccacatat 575161 atatatatat atacactttt atacacctaa taatatcatc ggcattatga ttgcttatac 575221 attttcataa tcaatattac tgttcaccat ttgaatcact gcagaaatat gcactgcgcc 575281 ttctttttct ttgcctgaag cacccacaca caagaacagg aatgtgaatg gcctccccat 575341 ctcactttta cttaatagta ttctgacaat ataaggtatc agagagtaag accattatta 575401 ggcaaacaat aatcttcaga atttttagta gcgcattctc aacctttcta ggtgcgtttt 575461 tctaatgaaa tagtatcgtt ttccttccgc attccttgcg tagtttgttg tgtaaatata 575521 gcaataagaa accctataaa tcattatgat gtaactcccg attcttttaa ataattacat 575581 aaactaggaa ggcaagtccg aacacgcaga gatgaggtat ttgcactcaa tgacaaatct 575641 aggtttaaac tacggggctc cataccttat ctcttcactt atcaaaagta ggcaaaagaa 575701 aagaaaataa atataatttc tttttctgca ggcaagattt taaaagaact tgcgcgtcct 575761 ctgtgcaatc tacctgggga gtctcgggct ttaaccgctc cccattctaa actgcttcca 575821 ttgacgtgta ctatactgct cacttcttgc tcttcgagca acaaaatctg tattacgttt 575881 cttacactag tcgagtgaaa gagataagat acccactttt acttgccggg agaatggaaa 575941 agagaaaacg gaagaaaggg cttaaataca ttttccttta atatgaacat cctactgtaa 576001 gataaaaatt ggatgctgat aatggaaagg agacatgtac ggtatgtacg gcaaaacctc 576061 ggcgggtttt cgccgctagc tcatatattc tttcgttaaa ttttaaaatt tcttattcta 576121 aatcttcttt acatgtttgg aaagaattta ttggagagaa aaatctagac ctgccaagcc 576181 gataaacgaa tgcctgcgaa gaaatagtgt aaatattact cctgaaggta gagtcatcta 576241 ggcggagacg aaaacaaagt ttagcttttc gtgaaattgc ccatttcatg tttatcaacc 576301 accaaaggtt aaatggaggt ttgacaaaag aaattttctt gctaaaggtt agcatttttt 576361 ttggaatttt ttttccttcg actggctgta gttgtccttc tatattacgt acaacaaaaa 576421 ctttcttgaa tgaagaatta gttctatcat atagaccata agaaagaaaa cgcacttgga 576481 taatttttaa caaagaagag ggcaaactga cgctcaccaa gctattggtt tgtttggatc 576541 aatcgtcaga tatgaagccg aacaatcgaa cttgtgatgt aattaccaac aaagatgaat 576601 ctcttcctgc acttttgctg cctgcactga acagttacac ctgtgacgat tcattgctaa 576661 aaggacaaat ttcaagcaat ggcagatatc aaccattcgg gttttctgat tgctctttac 576721 tgccaaagcg tttaaacatt caggcagggc aaggatctat gccagtttct tcgattcaat 576781 gtgcagacca cagttatagt aattggcaaa aagaatccga aaagactaag cttcccaagc 576841 ttggttgccc aacagagtac actgaatact ataaaactgt ttcttccggc gaaacaaccg 576901 attcagcggt tgtttcatct atagcaacga acagactcaa aagaaaacgt cagagggacg 576961 gcccaagttg tgactcttgt aggataaaga aaataaaatg caatgcaaca atcattatct 577021 ttttacagga taggaaccta atttcatcaa tttcttcaaa tttgcattat acactttccc 577081 aagacgacat aaaccagttt cgaatgaagt ttttcaggaa actgcctgac gtgatgggca 577141 catatgaagt cataaaacac cttgataaaa tagtcctttt caaagcctgc acctcttgca 577201 gtagaagaaa ccaaaaaaat ggaaagtgtc ttttttcgag aggatttaca aaatctgata 577261 tgaacgtatt tcccaagata aatagtaaac ttaaagacaa aagtatcttc gagatgactg 577321 tcgatgatta tgttgccgct ggcttccaaa ccctttaggt ttcatgcatg taatttcctc 577381 ctatgtaaaa tataggaata ttaataaaac gcaccaataa taagttagat atttttctgc 577441 aagatataaa tttgtttact catacatata tattctattg cggggcgctc ttgtataagt 577501 aattcaataa aaaacctcta tatgatacaa ttgaccaagc cttcatttac cattctatat 577561 caatttggaa agaagggtat ttctctattt gggctctaca ttataacgca atcttatacc 577621 cattgcggat agctcagagt ccaagtactt caacacaaat ggtatggcca ccgtagttgt 577681 ttcattacca ccaacaaatt tgttaccttg tccatcttcc caaatttgag agtcgtcaat 577741 aaaaattttc tctccatctt ctgatttagt caatagcttc tttgcatctt cgaatctcat 577801 ggaacaacga cggcaacaaa cggtggaaat cgaaccaatt cttggcacac tctgttgcgt 577861 ggtcaaaata gaaccacact cgcgacatac ggatgcctgt gtgtagtctg atgaatttag 577921 cagacgatct tgtaatagaa aagatgtacc atgcccaatc aaagcatctc tttccatttc 577981 accgacacga ataccaccat gtctctttct acctttgaca ggctgcatag tcaaactatt 578041 cacaggacca gtggaacgaa cttggaactt gtcattgacc atatgacgta atctttggta 578101 gtagacaaca ccaacataaa tatctgccct taattcttca ccagtagcac ctgagtacat 578161 tggctcatta ccatggtagt tgtaacccgc cttcgctagt tgctcaccaa agtaatcggc 578221 tggggtatcg tcctcgttaa agatccaagg tgtagagtcc tgtgcaatac catgcaatgc 578281 ccccgcttta cctgctaaag attcgacgaa cataccaatg gtcatacgcg aagggaaagc 578341 atgagggtta atgatgatgt ctggttggat acctgtttcg ctaaaaggca tatcaatggt 578401 tggccatttt cttgaacaaa cacctttttg accgtgtcta gaagaaaatt tatcaccaat 578461 ttgaggcgtt cttctaatac gatattttat gctaacagtt tgtagttctt ggaacttatt 578521 ggattcatca ccgattaaat ttacctcttc gatatatgct ggttcagagg agtgatatgt 578581 cttgattttg gtcttattta aagtatcgtc aaagtatgcg cagattggat caccctcttc 578641 aacataagtg ccaatgtatg gcaaaccatc ctcgtctaat ttctcaagcc actcctttgg 578701 ccattcgtca ttcccgaaac caaaatgctg tgtaattggg tcaccacggt ttctgttaag 578761 tgctaaatcc actttctcag tcttatacat agtaccataa ccgaaacctc tttcatctgc 578821 tgatttgttt ataatcattg catcatccat atcataacca gtatacgaga tgaccgcaac 578881 aacagcatta aacccgtttg gaaagttatc catgccataa tcatcatata aattagcttt 578941 tacgataggc gtttgacctg tttgcaacct atacagctta ttgtcggaac gatggcacaa 579001 agctacaccc ggagtaccca ttgtttgttt acccatctga cattgataca tgtttcttgg 579061 agactggttg aaatcagaaa atggagtcaa attagccaaa atagaaagaa tatttgtggg 579121 cgtaaattct acgtgtgtat gaacgttatt ttgaatttct tgaggagtga cagcaatgtt 579181 catgtacact tgctcaaaag gtccaacaat gtcttcttta tccaaaggca ggtaacgaac 579241 aggacgcagc atcctagaat gaccaccaaa taggtagaga cctggatatt gaccacgagt 579301 tgagggagga acatatccaa tttctagatc aatcggtaac ccaggcgtct tgccttcaac 579361 tttccaatat ctcaatgtat ccgcaatgat cttaccttgt tcatgagaga cccagccaat 579421 aattttacca tcaatttgaa cacaacacag agaaggacca gcagcaaagg tgtgagatgc 579481 cggagcaaca ccaagtgagt ataatataga aggaattctt gagacgtcag attgctgagt 579541 tgatatacga cacttgtgcg caaaatggtt taataaacca caaggagaac catctggtgt 579601 atgaacaggg cacaggaatc cccacgactc aggtagcaac tttctgactg tggtagtttt 579661 caattgcgca aaaaaggagc ctctatgaac cattctaaaa tgagagataa aacggtagaa 579721 gttaattttt tctgcaacca cagtataacc agaaacttgt tgtaaatcta acccagactg 579781 ggacaccagg ttaccagttg ataaaaagta ttgcattttg gaaccaatgt tttcattaac 579841 cctcattaaa actcttgaca tgtacctttt gtctttgaaa ttaatggcca taccacggtt 579901 aatatccatc ctgacttgag caataatatt ctgtaagtac tcatcaatct tttcttttag 579961 gatcatacca tataagaaac cacccaaaag aacttcttga tgttgcgtag catctgggtt 580021 atctggagaa cattcgcctg caaccaagga atacaacttt ctgatcatga acaataacat 580081 tctgaattta tcctggctgc catccttacc caaatgcacg agaacgatgc gatcaaggac 580141 ttcttgtccg acttctaaat cagattgatc aggggaagct tgaaagacaa cacgaaattt 580201 gtctcctaaa tattgcaaga cttgtgtgcg attttgtaaa tgaggatatc ttttcttaaa 580261 accacgtaac agtaattcta aacgatcggt caaaaaggaa tccttaacgt cattaccaat 580321 aataccatca aaaatttccc tatcgctggt atgacacaag gcttttaaaa tcataacaac 580381 aggaactaaa tattcatttt ttctccaaga aaatctaaat gtaacttgac cgtcatttaa 580441 gtaatgcaaa acattagttt gggaagtttg atccggcctg acagatctaa tttgaatacc 580501 gtaatgagaa taggatgcac ccctgttagc gaaggaaggt ctgatgatag ccataggatg 580561 atttctacgt tgcacaatca gcattctaat aagcttttct ataccgttaa caatgaaata 580621 accacctatt tcatcggatt cttccttgtg ttgtaccagt tcatatggtg acatcttgtt 580681 caagtgacat ctgttactct gtagcataac tggtagacca ccacaatctc ttacttcaaa 580741 taagttctcc tcgccattgt tcacggacca cttcaacttt aaaagtaatt tacctctgta 580801 agaagtaagc ctttgtcttg actcacttgg gtaaactttt ctctctactg cagaagaaac 580861 accatcgtta gacattggct tcgcaataga cacttgttcc acactaacag aaagcttatt 580921 cccgaggtat ccgctgttgg atatttcgtc ttcagaattg agtggttttc catcaaatat 580981 aactttttca ccgatgtctt taacaccaag atttaacaaa cctccatccg gaccttctgt 581041 taatgcgtta aaagacccaa tatgaggttg aacagcttcc tgtaatagtg gaaatgctga 581101 tttatcctta ggtggattga tgaacctaga ttcacgttct aaggtacgga aatcagcagt 581161 tctggcttgg ccaggcggct taatcacttt gctcatctca ccaaatgcgt aattctacgt 581221 ttatttgtca atattcttga ggaagacttg cttgaatatt acgagacagc tgaagtaagt 581281 ttgaataatt aagagatgag atgagtctct aagatgcgct tgaaaaattt ttcatacgaa 581341 aaaaaaaaaa aaaaaaaaaa aaaaacactc gcaagagtaa tctcaataat aatttccgtc 581401 attagcgatt atagcatgaa gggaggccga gaggccgctt ctgcggtatg ataattaagt 581461 ggtagtgcag agactcaaaa gggcgctgag aatctattag aaatgccatt aagtgctttg 581521 aactcttgta gcatgtctgc ttctgtagat ataacactct gatgcagatt tatgaataat 581581 ttcatcactc gatgtcatca gcgtcttcct tcatttgatg cttttttgaa gttttcatgg 581641 catgatttag catttgaaat ataatgagaa aagagccctt taacttacag aagtaaatgt 581701 acaaaactta atcggaggaa gaagcttaaa catacaaaaa caacagcagg atgactacaa 581761 agaagccgtt aaacaaatct ttttgtctcc gttactaatt cactaatata gtaattttgc 581821 taacctctat cgtcattgaa actgatttgt cctcgagaag gcaacaatca aactgcaaaa 581881 gaaacgtaaa gcaacgactt gaacaagtaa tcgctaacca catattgaga taagcagata 581941 atcgctgtta aacgtcgttg atacagtcag tcaatatgaa tagtgtagta ttttatcgtt 582001 aggttcacct tccaaatatt cgttagataa agatgtttcg gttttttatt tcaacaaaag 582061 agccttgttg gcgcaatcgg tagcgcgtat gactcttaat cataaggtta ggggttcgag 582121 ccccctacag ggctttcttt tttattgcat ggtctatcat caggttccct taaccgctgc 582181 caagaaagag cacgtgtaaa aatggaatga ttatacatca attaaacata tagtcatggt 582241 ggtgttgaca tgtatataat atacattagt tttgtcatat ttgaagaata aataatattt 582301 cgatttgttc ccgacaatta ttgaaaatgt tttaagtgta gatattaata taacaaatca 582361 tcaacatggt ttttaatcct tatctttggc aaggacttca tctaaactag ataattctgg 582421 gttacctgtc aatctcaaag tctcgtcagt tcttaatttc ttatatgtga agtatgtccc 582481 agagcataaa gctacaccaa cagcgagaaa taacggtgtt aattcgacgg gtattttgta 582541 gccaccagat gtttttttct agttttttgt tagtataata ctctataatc ttgtagttag 582601 cattcataat caacataatt gttttcttag aaagcatcaa gtcagaatga acgcatgatt 582661 atccgtttgt cacaataaaa agaaaatatc ccttaacata cagctgtatt caacagtaac 582721 tgtgctggtc tcatttttct atatttttct ttttttaaag tattgtcaga agtcgttcag 582781 gaaactacca aaattaaata agtctcaaaa caaagttagc ttatactggt atgggaagag 582841 ttatagttgc ttttgaggag atggcgatgc ctttaaagtc tgttctcatg ctcatcataa 582901 agtacgggaa atcccccgct ttgtacgata tgattggccc atactgcaag accgatataa 582961 agaaaaatag acaagttaat gctatataca ggatgtcgtt cttcagcgga gggatcgcgt 583021 cattacttgg ttttcgctga cccaagcctg tcacctcaag ctcaccaatt tcttacagaa 583081 tcacatacaa cttcgtaaac tagccaactc actgcagttg aaggaacaac tttaaaaagg 583141 tttgcagcta agcctttgta gtaaccgcta acgccttctg ctctgccgat tgtcacgagc 583201 gcatcccaga cactcgtgta tctaaatccc agttcatttc cgcccattgc gagaacttga 583261 aatcttcttc ttagcagatc aaagggataa gtgattgttt gcgcaacccc tccacttatg 583321 gcgccaattg ttaatttata gaggttactt ttccaggaag gctgagcatc ggaggaattg 583381 acaccgaatt ctctcaattg ttcgtaaact gcaaagttta gtgctacata tggaacaaca 583441 ccaagactcg ttggccatac acccctatat aatcccctga gaccgccttc gagtctgtaa 583501 gtttcgctta gtaattgcca gatccccgga ggctttgata tactttttgc ctttgagcgg 583561 tttaaactgc tcaaatttgc tgtctgaatc gatagtcttg ttttgatcaa gtccaacggg 583621 taagtagcca ccacactaca accaccacac aatgcaccac tgaatagtct ttgggtgttc 583681 gttagttgtt cttgtccatt attgccattt acatggaata actttttctt acaagcttcg 583741 tatactacaa actggactgc actataggga aaaattctta tgcagttcaa accatttcct 583801 ctgaataaac ctttggttcc ctcctcatgg taaacctgcc gtatagagct aaagatacct 583861 cggttataag aagtggttga actttgaact tgcagcagta ttttaactct ctcaaaaggt 583921 gaaacaacgg ttcgggaaac cgcgccagct actccaccag ctagaaacgc aatatttgaa 583981 tcctgcttga gaaaatcttt aattgagttc ggctgctcga ggacggtcag tacttctgcc 584041 atgttagcga aataacgatt aaaaaatttg aaagtcaata ctatgaaaca aggaaacgag 584101 caacttggta tacttccctc acctttgtta aattcacttg gccttactgg caatcataat 584161 cattttgacg aactgcggac atcgagagta ccctgcaaat atatctagaa aaagaggtaa 584221 aaaaatattg aagggtcaac ctgaaaaaaa ttgaaaagtg aaaatagatc tgctgataaa 584281 taatgcacgg cttgcatcaa gtgatcacat ggaactttcc caatacctca actacgcatt 584341 ttcccttgca tattatatca tcatccatct tctttgcctc tcatatattt acgaaataat 584401 acataaacat aaaaacgtct ttgtgcgtcc aagtaaactt gaagacgcac tcccgttata 584461 taaaactggg aagaacacta acaaagaagg tgacttgcgc ttaattagtt ttattccctt 584521 gcttctaaag tccgtaaaac attctattag agtctataca tagttttgcc ttacctttga 584581 atatgagttc taaaaattcc attgcaataa agctttccgt tcctattgtt tctatgtagt 584641 gtttaagact ttgtttcttt tcctttcatg gcttttcaaa tgtctcagca tattgctttt 584701 cacattgaag gattttgtgc aaccctccca agtacatttg aaaggagtat ctcccgtatg 584761 aattaagtaa tgtgtcttca gcgttgaggg cctcgaacaa atttttccac atactgggca 584821 ctgctttctc agctttgtgg atgatattcg ggtgtcagtt ttccaatcag aaaatgttgc 584881 tgaaccgttc aacacggcac caggttcgct ttttgttctg ccgttactgg cttcctgcat 584941 ggttggaagt acgccatacc caggtgggac tgattttggc ctatcgtggc atagctctaa 585001 ggcagcgttt gggtgactcg ccattgatat tgcagtgaag ttaggttcgg aggcaattgt 585061 tattggttct ttgtcgtatg gtgtcaatgg tttatatact gttgggacca tgactggcat 585121 catcaaggga gcagaggagg tcaaatgagg agactggcta tgtggtattg gttgctgact 585181 ttccgtatag tagataggat attgatcaga tgttgcgttc atggaaattg gggtgtagat 585241 ctcattaaca atgggtacaa cattcatgct ttgataaact tgctgtggag ggaattgaac 585301 ccttgaatct acgttaggtg gtgtattatt ttcaaaatta ggcaaaaggg atgaaattgg 585361 tggtaagttt attttcgtac tattataaca ttcccgttca tttttgtagc tattgtggcc 585421 ataaaattga gtccccttac cagtgctcag ctgatcaact gcggacactt gaagggggag 585481 gttcgattta taattgactg tacacattcc tatattagga gatcttgact tgtctgtata 585541 tgatgattgt ttttctgaac tttgctttga aagggaaaaa ttcatgtaat ttactttagt 585601 ggcgtttact gctatttttc gaaggtaggt gatgaacttg tgttataact aagaagctca 585661 aaactaaaag tatactaatg tttgaggaat tattgtgaag ccatagaaca ataaaaagct 585721 aacaattgta tctttcgttc aacttgtcaa accctgacag gcatataaaa gaggtatttt 585781 gaaacatcaa catgtagtag tcacatatat agcaaaatag taagtaagga aaaaaagaag 585841 gcacagagaa tacaacaata atgatgaagg cacacgactg ccctttccgg gccacctgca 585901 gatctgtaag gtagttcaaa tgacgttctc gcgcgggttt cttacttatg aaactttagg 585961 gacataagtc gggaacctga tgcatcattc tttatcttgt tttttgttgt tgtttgagtt 586021 tcttgtacag aataatacgc agaattaaag cggaagttaa aaaacagatc gtcttgatct 586081 gccctcaaaa ccagtatcca ctgaaaacct tatttcccac cgtaaatggc aatcactcgt 586141 agctcaaggt ggaatgctcc cgtaaggata tttcctatat gagatagtcc cgatcctgag 586201 aagagggatc gccgtcattt tattctttaa ccccgagaaa cggcatctct cacctgattg 586261 ttctcaagat tgctgcaaaa cccagatata cttttaggta cggagcgtac gcgatgtata 586321 tggattgatt ttcacatgta tcgtttatga gtacttgact gcacctcgtg tcggaagatt 586381 ttccaatcgg gctttttttc aatcttgaag gccctccttt tcatttccat ttgctctgac 586441 attgcggcta tgcatcacag gcaaaagctg aaaaggaaat tttgtagcgt atcggtttac 586501 tgcacagtct cagacccttt gtagtactgt tacctggaag aatagtaggt gcgtacaaca 586561 gtgattatgt agtagtatct actgaagagc ctacgagcga aaaaaaaaaa aattatcggc 586621 tacattacgt tgtttcctac ggagacaaga accaatataa gctgcaaaaa atctatgagc 586681 attttaagtt tccgatacaa caagatgtat gcgtactatt cacgtcgtgt tatattgctc 586741 acgtaacaac ttctatgaca ataataaaaa ataacctttc cattgtatca ttaaggttat 586801 ctacggagga ttgtcaaacc tagcggatat gaaatgtact tgattcctaa ttcgggttta 586861 tttagagttc agactatgtg ggtcatttct tatgctaata ataggcactg aggtaagtca 586921 aaatagcgac actcaattac tgttgaatgg gaagaaaaaa ccgagaaagg gatacagaga 586981 tcttgcccac gccttttttt caaaaagagc ccttcgcaag gttgctcaac gggattgtca 587041 tagaaagaaa aaatcaaagc caataactac aaggccaaaa gtaatggtag ggagctacta 587101 caaagtgggc tcagcctacc tgaagaaaat aaacaattaa tggacaagat ctgttagcgg 587161 acatacaaga gatcaaatta ccttctggtt aatgctgtag gcgaagcaaa ccattcaatt 587221 gaggaaacct tattcccaat tgcgcttttg ctccctggaa gcctataaca gcgtgtgggc 587281 aaataaagtt gtttttcgcc ctcagcgact ttacttcgga aactgaagag cggctagaaa 587341 tttcgcagaa aagattttcc tttgaggata gaaaaatgaa aaaaagaaat ttatcttttt 587401 tcacaacagg tgctgctttt tcctcacgta tgcacagaat gcaaagtaca agatttgtaa 587461 tacgcgactc cgcgcagctg tactctactc ccaagtcagc ggaaaaaatg caagacatac 587521 agaaagttgc cgctttattg gctatttttt tgggcgacag ccctggctag cctcctcatt 587581 gggttgtaga ggaaacaaaa ctgagatgtc tttggactaa tgtcagcaat aataactcgt 587641 aaaatcaagt cagaatttct atccattcaa taggtattca ttgtttatga aactaagaaa 587701 cgaatgtaaa taattctggg atataacaaa tagttccctt tggattactt aaaacatagt 587761 actgcagcta aaatttgtaa aaatgttaac gtttctttgc gttgagtaac ttgaccttca 587821 cacgtagttg caagtaccga tgcaaaattt ttacactggt gacaacctta atggtataat 587881 ccaattagcg acatcaccga gaaagtatcc aagtcgattt gatgaataaa ataataactt 587941 aaacattcaa cgccgtttgt taatactgac acctgaagga gagtcaaaaa ggcaaacttt 588001 cttgcaacaa tcataaagct aaggcaccgc tagagcttac gatattggcc gcaaaaataa 588061 ctattacact ttttcgtttc tgtggaaatg tagggtgatc aactggctaa ttgctgcctt 588121 ttaagatatg cggaggagat tgtgcagcca ttttcatttt agcgactcat tgatggaagt 588181 attcaagtca agatcacttg tttaaattca agactactgt ttaaattcat aattttttat 588241 tgctatcttt tttttaccac agatctgacc gacactcccg cttatcgccc attgcggcat 588301 atacttaggc aagtcaaaag ccgaggacag cagttgaaga caggctacaa tttctatagt 588361 agcttttttt cgttcctaat ttctccaaac actttaagtt tcttgaaacg taaatgatac 588421 tgcgaaaaat ttgatttcgt tctgaagata ctatcaatta aacgtgcact aggtgctgtt 588481 ccctcgatga gctgccgcgc taacccgtac cccccaattt tgagcgattt tagtgagttg 588541 tgttatataa tccaggggta ctctgctccg cgatttgtgt gatagcagcc ataaatgccc 588601 cacgccaaag ttccacgttc aaataaaact tacatcaaaa attctttctc tttgaagtaa 588661 atatgcgtgg ggattgctga ataagcagcc cagtgaacat cagcgctttc tgtaaatcat 588721 ttatcagcta acaataatta cataatataa acctccaata actgtcctgc tagtggcacg 588781 ttgttggctg tcagaaacga aatgtgggtc ctatttaccc cttggtttta gtatgggagc 588841 acgaatggta aacaccttct cataaaataa ctgataacgt cttaaagcga ccaaatactt 588901 tattgttgcg ggcaaacatt attgttaaat gcgtggtcta gaagtaaaat tttctgcata 588961 gttcactgtt atgtaaattt tgaacttgaa atcttttctt agaaagagtc tgtcatcctt 589021 ggaaacattg ctgaccaaga atacgatatt gtgagaagac attgtaccca aaaaaaattt 589081 ttcattccta tagtttggat tggagatgat tcaaacacag catattcatg tgttaccttc 589141 ccggttatgc acgaggtcaa tgagaccgtt cccttgtgtt gtaccagtgg tagggttctt 589201 ctcggtagct tctccgcaat aagaatgatt gaatcatatt gtaacattag attttggcct 589261 ttcactaatt accgtaggta attttgttgg ttaaactgac aaagaataag agtttaacca 589321 acaaaattaa gtcttggtgc attgaatgga agaaaagatg atacaacgcc aacctaaaga 589381 gtggaaagcg ttctttcaaa tgagggtagt aggaaattca gcgggaaagt ttgaaaatgt 589441 ggtggtaaaa caataatcct ggtttttctt tgttatccga taggaaattt atccccttct 589501 atgttccact aatcacttca tgggttgact atcactagcg catgaactcc ttttgaccaa 589561 taataagcac aatactaaag gttgtggtaa ttgataaata aagacttcca ttgaaatgac 589621 agaaacgata tgtatgaatc agaatatcaa gcatggatat atcattgcgc tcaaacttag 589681 tcaaattcct ttgttttctt agtttgttat gactcccttg acgtaattat tcttgcatta 589741 attttgagct tctgtaaact tcattgttcc aatggatcat tatatattaa caacgttggc 589801 atatacgtga ccgcaatttg aactacctac atttaacata cttttgtaga ggaaagaggc 589861 tgtttgttct ttaaccatga ttataccaat ttaacctttt tttttttttt gatagtgaac 589921 tgcatactag tcaggtaatt gaattcctgg tacagagatt catcaagaca tccgtgtcgg 589981 caacgttgta ctaaatgaaa aggtcctttg tcttacgaac tagacagaat aaaatgtatc 590041 gtgcggcagt atagaaccgt attacaaatg ctgatgcatt cgcaaacaaa tttcttgtag 590101 aaattataat tcgaacaaaa atcctctcac tattcaaaaa tcggaagtca gtaaaaattg 590161 attgttggct acatgtaata tattatatgg aactaataca tatctatact cattttactt 590221 ggtaaaaagt gtcacaccta catcaaaatc acactgaaaa caaaatattc taaacaatgc 590281 tttcactgat gttttttctt tgctattttc ttttgatggg ttcttaaatg ccttaacatg 590341 ttactcttga cattgaaaga tttgttgcaa tgctcccaag tacatttgaa aggtgtgtct 590401 cccgtatgta ttaagtaatg agtcctcagt gttgaaggtc tcgaacaaac cttcccacag 590461 ataggacatt gtttccgtag ctttaccaca gcgcgcagtt gcttttgtat aagatctaag 590521 tcggtttgtg tttgggataa tagcgtccca ggattttgcc ctatatgcac attcgggagg 590581 gagtactgct cgttgctcac cgctctgtgg ttttcctcct gaaaatgctg cattgatgga 590641 ggtacagatt gggcagtata agaggaagct gccgttgaat aaatagggca acaagattga 590701 cgttcaacga acgttaaagg gaaaggttgc ggtgttgcta taaccggcga aaagataata 590761 gagttgggac ttgatctcca tacgggatcc tctgtctgat gcagagaaga aggtgcgtaa 590821 tggtaagcgg gaggtggtag tgcggcctgg tttatttcag gagtaagtgg agcgtgcata 590881 atcgacgaac aaggtggaag atgcacttcc cttttggtcg tgttcgagac ttcctttgaa 590941 gattgcgcat aggatccccc tatgttagac gatgaacatt tcattgggct acaaagcata 591001 gattctagcg tttttgttct ccacatttaa ttagtgttga agatgaaaat ttatgtatat 591061 taaaagttag aaacgggtca atgaagacgt ttgcttatcg tattggatcc ttgcaatgcc 591121 ctccaaaaag aagaaaaaag ttggaccaag aaaacaatta taattttgta atttgaaata 591181 tctaccaatg aggtcaaaag agcgacaaca actagcgctt atataatata aagaattctt 591241 gggactgtat ctcatggcaa ccaaatgccg ttcatattta gggtttcagt gggaaaagat 591301 ttccggtgct ttacgctcct tgtacaaaca agtgctgcga aactttctgt ggaaatcgtg 591361 ccttttaaac cattagtgaa ggctccagat agagttgtca cagaaaacag cgtggcggac 591421 ttattttttt gcaacgattt tctggaaaca atagaggaag aatttttggc gtacgaaaag 591481 gaacgatgcc cccaacacct caacaatact acggaagttt cttcgagcgg aaaaacatcg 591541 aaatactagc tgtttctgga tatgagagtg ggtatgcgtg gcaatggaac tcagggagtt 591601 gttgctattt cagtgagtac gatggatcag ggtgtttata tctcaagaac taccaagttg 591661 aagagatgaa acgtagttcg cttgatagca cataaatgga cggctgactt gttgtacacc 591721 atatatatat atatatatat ataattttac ggctcacttc tgtaccgctt gtgaaaatct 591781 taccgcacaa cccccggtgt tctattagct ttgttcgatt ttattaatct ttgccaagag 591841 atactactct ccgggttctg gtggagacaa tagtatgtcc tagcagctag acaaaaaagc 591901 cttcaaatgg tctacgtgcg gtgcaatttt tcttggagaa gttctatatt gtctaacaga 591961 tacttggaac tgagcaagtt gtcagaatag tcggagaagc ggacggaaaa tccatattat 592021 gcaaagaatt tgcttagaaa cccgttacat atgcttcgaa caaagtgact acatgttaca 592081 attaagacgc ctacttaaac tgcaatgaat agtcacccat aggtataaga aaaaaaaaaa 592141 aaataaaaga gtacataata tacatacaac taaaattaaa atgcatagaa acctaagaaa 592201 aaatatttgt tataccaaaa aaaataccac aaatgatacg taagaagatt attgcaacat 592261 ggggactctt tcgcatacaa ctgtaaacag acttgaggaa ggaggggaat cccctcagga 592321 gtacctgaca tctatgagta ggtttcaatc aaagtatcac gtaggttacc tgaaatggat 592381 tctggttggg catcttgcaa gcggaaaata ctttcaataa cactcaattc tggggctgta 592441 gtatccagac ctgtaactgc caagtaatcg ttcacaacca taccggcacc gacaactgaa 592501 ctaccacggt taacggtacc agccaccaaa ggaacttgta ataaggagga caattcttct 592561 tgatcttgga cacttgtttg tggatgcact aacccacctt gattacttaa agaacaatat 592621 gacccaacta agatattacc tgatatggtt tgacggaaga cctcaacgcc tagtacatca 592681 cttatcaatt cttcagtttc tctgtcgata tctggatgca ctaaagcaac gtaatcatta 592741 caacagatga cgttacccaa ggcagatagt ctttcctcta ccctttgaat cttaacggaa 592801 tccggcaaac tatttcttaa atgttgtaat tcttgatcag tagtttgggt tggaactagc 592861 agacctctac ggttacccgc ggtcattcta ccgatgatac gcgtaccagc aatagtggta 592921 tgaacgatgg gaatagcatc tcctaattca gcttcaaatg cagagtaaaa gttttcagaa 592981 ccaccaacag caaccaaaca gtaagtattc gttaatttgg agaatacacc gatttcattg 593041 gagttttcaa attgagtcct ggtagccatt attgttttct agagttagtt gaattatgct 593101 cttgttccaa atactctgtc gtattgcttc ttgtaattat actataagac caacgaggga 593161 tgaggcttct tttaattatg caatattgaa tattgcgtta catacagtaa aagaaaaaat 593221 ctgcacaaag gaatatgggt ttaaatcttt aattaataaa aattttccga aaattttcgt 593281 ttggccctcg gaaaaaacgg gtaatgctca tccattagga tttcgtccag aatgcctata 593341 ttattacata aagtgatgct agtaatgtaa accagaacta cttctatagc ttgttatagg 593401 tggcccatgc cagtgaaata ggtggttggt tactcttttt tttttctggt ggcggcaacc 593461 tatttttgtt ctagtgccta ccaaactaat tccttcccat aatttgaagg cttcgcaagc 593521 ttagtagatg caaaactctt tcttcattct ttgtctgatc ttgcacctta catattattc 593581 caataggacc tttatcacaa tcagcgcata tcaaatattt caagcacttt ttaatcttcc 593641 agctggaatt accatactca aagacaaaat cactcttatc actcaaatcc cctaatatag 593701 aagaaggaat ttctctagat acaccaacat tatcaaagtc ccaaacatca gggacgacca 593761 agaagttgct ctcgctgggg gtagcatctc gcatagttct gttttccagc aacttgaatt 593821 cgctgtgcac ctgctctggt aagtttatta tgttatcatc gttgatggta ataactgcac 593881 tatgacagcc ctcaaaggaa cacgtagcct tgctcatgtt ctctgttatt cccccatttt 593941 tccagccctt ttaattgaac tttctactca taccagtcaa gtttttgata tgtacttcat 594001 taattaaaat gatcgatata taatcgttca gtacgacaat gacgatattc acagtactac 594061 taaactagcg ggtccccggc gcccagtcag cctttacgaa gagaaaggaa gaatgatatg 594121 gatatgctga aaagtatttt gatacagaag aagggagttt tgagttgtcg ggctcatcgt 594181 gctggatcaa gtggttccct acctggcgcg atctatagtg tcagacggct tgcatatatg 594241 ctcacgcgtt cggacgcgtg aaaggcttca actgaaaaaa agaaagatct acatcgttaa 594301 accaaaaggt ttgcgaactg actaaaaaat aaaattctta ttggttccac ttcttgaaat 594361 acatcatttt tccagccaat tcgttgagga gaagaacatt ctgttattgc tgttacagag 594421 aattatatgt tttagtgaac ctcaagacag aagagaatcg aaaggaaaag ggaaaatgga 594481 gcaacatctc aaatcaattc ctctacagga cgacactaag aaaaaaggca tactatcttt 594541 tttccagaat acaactacgg taaagagtaa taagtttctc acgaaagaga aggatgtcat 594601 cactctagat gatcctaaag aggatgtcag tggacctatg atagaaactg ttaaacaaga 594661 aaccatgaaa agcatcaata aagagtgtgc agatgaaatg aaaacgacac ctaagaaggc 594721 caatgctgaa gacaagcttt tatgctacaa aaattcaccc atacaaagta caaaatacga 594781 tagaaacacc aacaaacaag tacccaatgg aaatataata gctatcgaga caaaaagcag 594841 aagctcttct ccatgctcta agagagaact ttcctcatcg aaaaaggaag aagctaaaag 594901 agaaaaggaa ctaaaaaagc agcaacgtgc agaagagaaa cacagaaaag agttattacg 594961 acaagaagag aaaaagaaaa aagagctaaa ggtagaagag gaaagacaaa ggcgtgctga 595021 gctgaaaaag caaaaggaag aggaaaagcg tagaaaggaa gaagccagat tagaagccaa 595081 aagaagaaaa gaggaggaaa gattgaaaaa ggaggaggaa atacgtttga aagaagaagc 595141 caaggaaaga gcacaatccc gtattggtaa cttctttaaa aaactaagcg attctaatac 595201 gcctgtggtt gaaaagtcgg attatgaaaa attttttcta cctttctatg ctaaagatgg 595261 agttagagtc agtaataagt ggaaactaac aaaagtggag ctggaaggta gcaaaagaaa 595321 aatagatgat gaattactga acagtaaaga taaaacaagt agtgacgact tattgaattg 595381 gttacagtct agaagattac ctagaggaca taaaattaaa cgtaaagctg ttgacgttct 595441 acagcaaatg cctttgaagg agaaaacaga cgatgagctc caatctttac ttgcacaagt 595501 tccgcacaaa tatataaaat tctacgaaaa tgttagacct ccgtttatcg gaacctattc 595561 tatggacttt actttgccac caaacgatcc cttttctacg aaaggtactg gattcaatta 595621 tgattacgat tctgacgttg aatgggttaa tgaagaagaa gaaggcgaag tcgataactt 595681 agaaagtggt gaagaggagg aggaggagga agatgatgaa gacgtaccta gcgaaggaga 595741 gtttgacggg tttctagaca gcgaagaaaa cagtgatttg gatggcctac cctgcgccaa 595801 gagaaaattt gtaggcccat tgataccaac aatatgccta aaatccaatt ttgaaaactt 595861 atcagaggaa aataaacgat acttacaaca actcaaggcc gaagttatca tagaaaccga 595921 cgggccaatc gatccattca aagaacccaa aacatcgtct ctaccatcca aaagaagtaa 595981 ttccgactta caggcacaga ccgctagcca atctcaaagt cccgaaaaga aacaaaaagc 596041 aatgattaca gaccccatgg acttacttcg actttttgat ggggttcaag acagcacgtt 596101 ttctttgggt actgtgactg aaatagcaca gaaaaatttg ccgcaataca acaaacaaac 596161 aattaaaaac accataaagg aatatgccat aagaagttct ggaaagggtg atttgccccg 596221 caaatgggta atcaaagacg cacaaaactg ggagaatctt cgagccaatg caaatatgcc 596281 aaccccgtct ttgtaacttg aacggatctt tagtatatag aaacatacag ataaactgat 596341 tatttattgg tatacatgaa aaaggcgaca acactacgat cgacagtcaa gccttttgga 596401 ctttgaataa aatccagcac ttctcgcatg caacaaaaga aaatcttcta tataagctga 596461 actacattta tctgtgtcag ccaactgcat gttttatatc acttcttttt ggaatattac 596521 gagtagattc atgaaaacgc aaacacttgg tttactcttt cgggaaattt aatgctagtt 596581 cgccgcctcg aaaatgaaaa gagaagaaga gaccagaaga gcaacttcgc attggcactg 596641 tttatttctt taagaacatc ttcaatacta aataagacaa cccatcttca gttattttta 596701 ctcttggtag agcccaactt aggatccttt tgaacctcaa gaacttaaaa tgtctcaaca 596761 gtctagctct ccaacaaaag aggataataa ctccagctcc cccgttgtgc ctaatcctga 596821 ttctgttcca ccacagcttt cttccccagc tctattttat agctcctctt catcacaagg 596881 tgatatctat ggtcgcaaca atagccagaa cttaagtcag ggagagggaa acatcagagc 596941 tgctataggt tcttctccac taaattttcc atcttcttcc caaagacaaa attccgatgt 597001 tttccaatct caaggcagac agggcagaat tcgttcttct gcgagcgctt ctggaaggtc 597061 tagatatcat tctgatctga gaagtgatag agcactgcct acttcttcct cttctttagg 597121 ccgtaatggt caaaaccgtg tacacatgcg aagaaatgat attcatacat ctgatttatc 597181 ctctccaaga agaattgtgg attttgatac tagatccggc gtgaatactt tggatacttc 597241 ttcttcttct gctcctccat cggaagccag tgaacccttg agaataattt ggggtaccaa 597301 cgtcagtatc caggaatgta caactaattt tcgtaatttt ttgatgtctt tcaagtataa 597361 attccgtaaa atattggatg aaagggagga attcattaac aatactaccg acgaagaact 597421 atactatatc aagcagctta atgaaatgag agaacttggt acctctaatt taaacttgga 597481 tgctagaaac ttacttgctt acaagcaaac agaagactta taccatcaac tattaaatta 597541 tcctcaagaa gtgatttcta tcatggatca aactatcaag gactgtatgg tttccttaat 597601 agtagacaac aatttggatt acgatttaga tgaaatagag accaagtttt ataaagtaag 597661 gccttacaat gtaggttctt gtaaaggtat gcgcgaattg aatccaaatg atattgataa 597721 attgataaac ttaaagggtc ttgtcctgag atcaactccg gttatccctg atatgaaggt 597781 agcgtttttc aaatgcaacg tctgcgatca tacaatggca gtggaaattg atagaggagt 597841 tatacaagag cccgctaggt gtgaacgtat tgattgtaat gaacccaatt ccatgtcact 597901 gattcacaac aggtgttcat tcgcagataa acaagtcatt aagttacagg aaactccaga 597961 ctttgtgcct gatggacaaa cgcctcactc tatctcatta tgtgtttacg atgaattagt 598021 ggattcttgc agggcgggcg atcgtattga ggtgactggc acgttcaggt ccatccccat 598081 tagagctaat tccaggcaac gcgtactaaa gtcgttgtat aaaacatacg tcgatgtggt 598141 ccacgttaaa aaagtttcag ataagaggtt agacgtcgat acttctacta ttgaacaaga 598201 attaatgcag aacaaggtag atcataacga ggtcgaagaa gtaagacaaa ttactgatca 598261 ggatttagca aaaattcgcg aggttgcggc aagagaagat ttatacagtt tattagcccg 598321 ctctattgcc ccaagtattt acgagctaga agatgtcaag aagggtatat tacttcagct 598381 atttggcggc acgaataaaa cctttaccaa gggtggccgt tatagaggtg acataaatat 598441 tttactttgt ggggatcctt ctacttccaa atcgcaaatt ttgcaatacg ttcacaaaat 598501 tactcctcgt ggtgtgtata cttcgggtaa aggttcatct gccgttggtt taactgctta 598561 tattacaagg gatgtcgaca caaaacaact tgttttggaa agtggtgcat tagtattgtc 598621 tgatggaggt gtttgttgta ttgacgagtt tgataaaatg agtgattcta caaggtccgt 598681 cttgcacgaa gtcatggaac agcagactat ttcaatcgca aaagcgggaa ttatcacaac 598741 acttaatgcc agaagttcta ttttggccag tgctaaccca attggttcac gctacaaccc 598801 caatttgcct gtgactgaaa atattgatct accgccccca ctactttcga gattcgatct 598861 ggtctatctt gtccttgata aggttgatga gaaaaatgac agagaactag ccaaacactt 598921 aacaaatctt tacctggaag ataagcccga acatatttct caagacgacg tgctaccagt 598981 tgaattttta acgatgtata ttagttatgc aaaggagcac atacacccaa taatcaccga 599041 ggccgctaag actgagcttg ttcgtgctta tgtaggaatg agaaagatgg gtgacgattc 599101 gagatccgat gagaagagaa tcacagctac cacaagacaa cttgaaagta tgattcgttt 599161 ggctgaggcg cacgccaaaa tgaaattgaa aaacgtcgta gagctggagg atgttcaaga 599221 agccgttaga ttaattagat cagccataaa agattatgca acagacccta aaaccggtaa 599281 aatcgacatg aatttagttc aaacaggtaa atcagttatt cagagaaaac tacaggagga 599341 tttgtcaagg gaaattatga atgttttgaa ggatcaggca tcagactcaa tgtcattcaa 599401 tgagcttata aaacaaatca atgaacactc tcaagataga gttgagtctt ctgatatcca 599461 ggaagccttg tcaagattgc aacaagagga caaggtcatt gtccttggcg agggtgtaag 599521 gagatcagtt cgcctgaata accgtgtctg atgctgtcta ctacaatcat tccctgcgta 599581 acaattaata aatactaatt aattatagca agtttgtatt ttttacatcc ttatgctttg 599641 taacactatt caatactgta tgtaggctcg attgagtggg cggctttttt cttattcctg 599701 attggctgaa agaaaatatt gttaaacgca ctaaatttat cccgaaggat gattacattt 599761 aaagaccgaa aaatgaagat gcaaagatcc ctcatatttt ctactccagt ccaaatcgac 599821 aagataaacc tgccgataaa tcatatttca gaacgctaat caattcatca tgctaagcag 599881 gatccaaaat tataccagtg ggttggtttc taaagcaaat cttttgtcat caaaggcttt 599941 atactatggt aaagtcggtg ccgagatttc aaaacagatt tatttaaaag agggtcttca 600001 accaccaact gttgcccagt tcaaatcagt gtattcgaac ctttataagc agagcctaaa 600061 ctttgctcta aagcctacag aagttttatc gtgtttaaaa aacatccaaa agaatgaact 600121 attaaaatat ggcgcatatg gtattcagtt gatagggttt tattctgtcg gtgaaataat 600181 tggaagaaga aaattagtgg gatataaaca tcactaagct ttttaattct atctattcgc 600241 aaaacccttg tatattcgtt aattaaatta aatcaatgta caaatagaac aaaactagaa 600301 aaaagaatat atattcatct caattctatt tattttcttt tcatgacata caatggcatt 600361 aaaagcgata tcgagttata ttacattagc ttcttgccgc cagttattta tgaaataggc 600421 caatataact tttctgtaaa aaagaaaact tgacctcaga gctttcatta cacttattaa 600481 gaacaacata cttgttgcac tatagtaaaa actacagtga aattgatctc aggatcatta 600541 gtaatttttc tcactataag aaaaaaaaaa aaacatatat tttgctatga attataataa 600601 gtaaatatat acatatatat gtacagagaa actgacgaag aaaataaatc acccgttaat 600661 gcttcttagg tgctcttgaa agtttttata aactgaagag tcaaacctag aaaagttatt 600721 gtccaaatca atgaatgttt tcgcaatttg acagctttta tagtaataat tggcatgttt 600781 tctatcatca gagtaaaact tttgctgtgg gagttcaccg ttactatgaa ctactgtctc 600841 ttcattgcct gcgtcgtcat cgatacaaaa tctcttccta ccctctctgc tttttaattt 600901 gttatcgggg gagggaataa agcccttgaa taattcatag gcggccagag tgaacccaaa 600961 ttggggagaa cttcttagga cacgggctcc accacctttg aaaaagcttc taaagctctc 601021 ttcctttaag atagttcgga tagcatgaaa tataccgtta tactttgtct caccttttcg 601081 aggatctatc tggagccttg tttttataac atcaaaagga gtagtcaaga aggcagctgg 601141 cataccagca atggcaccgg cagttaaaag ctcccatgtt tttaatcgat tcctctttgt 601201 tttatcattt ggatcaaaat caaagagatc tttttttaaa tgtgcataag tgggaaaata 601261 aatagcagag aatggaacat ctctcattaa acatgcggct acaccattgt acaagcccct 601321 cagtcctaat tttttgacta tttgagtggc agtttcattg gcttgttgta tgttttcacc 601381 aacatagtcg gattggacct gtagcctaat ttttacaatc tctaacggat tagtaaatat 601441 aacttgacat gcaccagctg aagcgccaga aataatttca ggaaaaaggc ttagcttgcc 601501 gtttttatca gtcaacctgt ttctcataaa atcattgaca gtcaatttta tcgccttttc 601561 aggagcaact cctattaatt gtggccctaa gccagagtag agacctttta ttccttcgcg 601621 ggatataatc ttcaacaaac aatcaattga gtttttgtat tgggctaaag atctttgggc 601681 ttgcatcctt gtttttataa agtctattgg gtatactaca gttgcaccaa tacaacccgc 601741 aatagaaccc aaggagaaat tgtacaacga atcgaaaatt ggataaaagt agtaattaat 601801 atacaatgac tcattttgat ttttttgcaa ttccatttgg tgaactaagt cgttcaggta 601861 atttgggttc aaaattttca tgaaatcttc aattgttaag tcagaacgca tcgttgcttt 601921 atctttttta cctccaaata cagattcaaa caagccagta ctcgcttttg aagctttttt 601981 aacaccagag tcttggtcaa atccatccga gagatcatga taatagtcat taaaactttc 602041 taaatttttt ctggatctgc ttactccatg caaatactca ttatggataa aaaaatcaat 602101 atctgaatca taatggtgat catttaatag ctcgtcatct cgatcttgat ttctctttct 602161 taatcttctg ttttcctttg aatttgcgac gatagaaaat agtaggttga tttgggaagg 602221 agagaactca atgatattgt ttactttgtt atactgggcg tttaaaactg tcataaagtc 602281 atttttagta actatttgtt ccctaatatc ctgctcattc aaattatttt cagtaacata 602341 cttgtgaaat atttggttca gtaggtcaaa attttgaaat aaataaaata tatccttgaa 602401 tacattgtac ggaatggaat tattgtccgc ttttagtaat tcggtgtttg atagattcaa 602461 ggaggaaaat atatctgcag acaccctgtg agagtaaaat aaccttagaa gataggtgag 602521 ttgatttttg cttagggcta aacgatgccc ttgtgagtcc atctgtgcca acctatcaaa 602581 acctataaat attttttcat tcttaagatc attttgtaaa atcgtgacca gagagtttaa 602641 actcaaatac tcttcatttt catgataaca tttgtaaaat ttcagaaatc gaaagtcatt 602701 ccaatcaagt agtaatttgt tatctttaac aaaattatca tcaatagatt cgtgcaacag 602761 gcggatagta tctttgaatt ggttcagatt caaaagaaga tcatcaaagc ttagaaatct 602821 gttaccataa ttaattgact taattcgatc atctgcagcc tttaaattaa acgacgaact 602881 accaagctct tttttttgtt ttgccttcaa attctctaca tcaaatttcc taaagaactc 602941 atatagaata atgagatgat aattatcata ttctaataaa ttattaaaat aaaaccaatc 603001 attaagcgtc agatatccct tgttttgttc atcaatagcg aagaaaatac acccgaaaac 603061 gttcttgggt atctggttca aattgaacga atggtccgta aacttcgaat aaatagtctt 603121 tgagctagat atcagttcaa tgaaatcgtc gtatgttaaa attagttctc ctgtaagctt 603181 ctccgtgtca ggtttcccat ttcctgctgt gagtttactg gagttcactg tcggcatatc 603241 taacatacca ttactgatac taataggctt gtcctctttt gtaaggacac ttgcaaaata 603301 tttgaatact tccaattgtt gcttcttttt tctactgttc gaattgattt gctccataat 603361 agtataataa ttctttaagg tcggtagcaa agctgcatac tttcaaacta cgctatgaaa 603421 gttatgtact tttccagtga aatatgttca caaagaaggg atcaggctac ttcgaaaatt 603481 atggcaaacg cgaggttgtg agataaaact tgaaagtctg gtgagattag atatcaaatc 603541 ttaacatata aaagacaggt tcgtcttgag gtatttatct atcttcgaaa tatttttttc 603601 tttgcttcga atactggtta attctgagat tcaatatatg tttcgagatg tttttccaac 603661 atgccggcag tactccccta aagcgatgct gcagaaattt ttcataaccg cttgcagtgg 603721 gatgaccaat aaagaaagct ctttctccta cgtaaaacat agatcatact tacatgtaaa 603781 atatgaagcg caattatata cagtgtcgat tttatttaac aatttcacag ctggcagttt 603841 acaaatgttt tcataaccat ttcattaatc taacaataaa tatgatgatt taccaatata 603901 cgaatataaa ctaaacatca aacatgttat gacaagtggg tgacgttttc cctaggctcc 603961 tttccaaaca attatcgaag agttttccga attcgcgccc taaatcccag tagctcttgt 604021 tgaaaatatc tctcataaac tgcatcatcc cgcatagaaa gtgggtatta gaaatatgtt 604081 gaagtaaact cgcttttgcc caaacgtcat tctgaaagct aactacatcg agtgagctat 604141 ccacatataa gttccgatac attctcaata ggtaaacttc aaaactttct attggaatgt 604201 aattgttctt ttcctttaaa ttgttgtttg caatcgtcga tccattatta tcagtattgc 604261 ctagaatgtt tccaccattg ctgtcatctg gttgaaagca ttcatccttt gaggcttctg 604321 tattatccca tatgctaact tcacagccat gtaatgcaaa attacaagac caaattagga 604381 gtgaagttaa tgcaatcgca tagggtctag taatcacagg atcagaattt atattgtagc 604441 tcttcactac ggttggaacg ttattttcct taatgataaa catttcaaat aagaactgga 604501 aggcatagac tacagctaca cccccattgt aggggtcctt agcgaactgg agaatcctgc 604561 gactgatcat gtcatattca tcgcgaccaa ttggtacatt cattctccaa ggtgctcctg 604621 catatatgta ataatcatga tgaagaatac gtaggacaat ttgagagata tgaataacgg 604681 gaattttaca atttgacgga ttatcggagg aaagcaagtc caaatcatca tcacatagtc 604741 catctccatt atcctcgtca atttttctgt tcgttagtgt ctcctcagat ggagtactta 604801 tcctacatgc tttcggatca gtgcagcttt tctgaacttc gtgaagccaa tagttcattg 604861 caaatgataa aatatctttc catgaaaggc ctaaatgatc agtgattccg cccctaaagt 604921 tagtaatgaa atagtcacca ttaacttcct cttgacattg aaataagatc gaaattatcc 604981 ccgccaaaag aatcttttta ccaaaaagac tctgaatatt ccaatctgta gtgctttcca 605041 agtctgtagg ggtactctct attccaccat tgttgacttt gtttctccgt atattattat 605101 ttcgtaagat ttgaatgaca tttttcatta attgcattaa cgcagacaaa aatgtattat 605161 tctcatctct ctttgtgctg ccatacccat gctccatcag agtttcatag ctcaaatcat 605221 aagattccca cacttgatct ggacagggta aagttagttg aatctgattg ctattaataa 605281 ataaattcca gtatccaaac actacagcat gtgtagtgtc catataaaat gcgtagaaag 605341 ctattctttt caacatttca aaatcaatcc atcttttata aacttcttgt gggtcttgaa 605401 ttgaattttc cccagaggtt ttgccggttt tgaccattaa gggatggccg cctaaagagg 605461 gcgttcgcct tagcaattga atggtcgttc cgtgatgtaa aaaagacctt tcatgtaaat 605521 acctgttcgt acttgttttt tcatatcctt cgactaataa taaactttga atgatgtagg 605581 ttttagaagg tggttgaaaa tcagcatgag aaaaaattat ccatcttaga ggaccacaaa 605641 ttgggtcact aatctgttca cgatactcgc ttcccaaaaa acttgcgcca gtcataatta 605701 gtgccaaatt caaaattgca ggctgtttat caacgtgaaa agagggtttg tgaagcagac 605761 cgtattgtgg atggaagttc aaccagaagg attttaacga tttgtgtata gattcaatag 605821 agacatagcg taattctgga acaaatgaaa acatttcttg acatttttct tttgatatct 605881 tatactttgt taagggatcc ggatggaaaa atgacgggac acttttcata gagtgacgca 605941 actgttcctt gtagttcaga gaggaattgt ttcctactcc tgaatcttta gatgatctcc 606001 gttttagctc gttgatatta agcttctgac tggaaagatt gtccttcact gaagtactgg 606061 ggttatcgtt gaacttcggt tgtgctttgg gaattttaat gttatcttgt ggtaactcaa 606121 acataactgg aggattctgg aacccttcgt cttgttgaac aggtttttca ttaggtggga 606181 ttgtattctt gtcagaaaat gtatcttcaa tacttacttg cggggcttca gaaagttctt 606241 gcatgaaaga ttgtaatggg tcgctgttca aaaaatttgt agaaaaaagg tcctgcataa 606301 ctgacaaatt agcaccgcta gaggaagatg ttaatggatc tccaaatgga ttctggggtg 606361 gtaattgttg ttgttgttgt tgttgctgtt gctgttgctg ttgctgttgg gcaagctttt 606421 gctgctgaaa gtactgttcc tgttgttgat cctgggtaag tggctggagt ggctgctgat 606481 atgaactact tgcaaaattt ctgtcttgat atcgttgctg ctgcacggct ggattgatat 606541 tcatattttg gtcattgcca ttaccgttgt tattcgctgc atccacttca aaaccattaa 606601 cgcctgtacg gttatcaaat atcaaattaa aaaattgatt accattttga ccgttgttcc 606661 ttattcgagg atcatacgat ggaaaagtag gacttgcttg ctgtggatgc atttgttgct 606721 gcaacatagg ttgttgcaat ggtgcccgca gttgctgcgg gaattgaagt tgctgcagtt 606781 gttgaatttg ttgtggttgt tgtgattgct gaacctgttg aggttgttga gcctgttgaa 606841 gaaaaggacg aaattttgat tcttgtgtga tagatggtgg tggattcaca gaatttttta 606901 ttaagttaat cgtagaagtt ccactttgcg tagaaagggg tacttcactg ggattatatg 606961 gtgcattttt ggagaagtcc ttatttgatg aggaaatctg gtccttgctt ggccgactta 607021 atctgttttt cacctttgaa tgcctctttt catgtctgat cagtaaatct ttccttacaa 607081 acgttttatt gcaaggcgca tttgtagtag gaagcacgta agaacaaaca tatatctctt 607141 tcggccagtg gtttagcttg tgtcttgata aatgttcctg acgtgagaaa gttttattac 607201 attcgggatg tggacaccta aatctttcag caggagaaga gcttgaattt ggtgataaat 607261 cgttatcatt ttcccttttc cggagcctgc cagccaactc tttgccgtgc atttttgcca 607321 atattaagag ctagcttcac tgctttattg gtcacttttt ataattataa acatagtaga 607381 tgagtcctag aatctcaata cagcctttaa aactattaaa gaagctgttc gcaactcaca 607441 aaaaaaataa aaaaataaag cagaacgaaa aaaaaaaaaa acaaaaaaaa cagttaacta 607501 ttctaattac ttagaatctt taaaagtctt actgtaattc gatcagtgga gaaggaaagc 607561 gcacatgtga tatctcgcaa tttcttctca aactaccttg acagtaattt ttcttaaaaa 607621 cgattggctc ctacatgaaa tccacgaaaa agcacggtag tcttgttaga ggacactgat 607681 atacgaggaa agaattgata aagcggaagg tctttggaaa caattcaaga ccgatgacat 607741 aacttttaag aggtaggtgg ggaagcccat atggagaatt ttaaaagcaa tagggtgctc 607801 gcttccaagc aaattagtac tttttttttt tttttagcag gagaataaag cttcaagcta 607861 atgcactaga gttcgaggtg catcatttca gttttttttg ctagggcata attgatcagc 607921 ctgttaaact cattgcatag tcagtaaatt tacaatcccc gaaaataatg gttcccttaa 607981 ataagcgagt taaggacttt tttttttttt tacagcagta gaccaacctg tacatgtttc 608041 atagtcaagt aatagcctga cgaatatcaa acgtttcctc tttttcattc ctttccttca 608101 aatgccttgg gttgaaagga tagacgtgta tttaatgcaa gctctatcta taatgagtgt 608161 tattacaatt gttatgcttc tgcattgagc gatgaataaa tataaacaac tccttttcga 608221 acaacttgta attatcctac gcttttgcct gaggtccttt ttagccattg acaacaagca 608281 agtgtctttc tgtatgaagt aaaccctgca taaagttgtt ttttgctgcg tcagagggtt 608341 aatgacttcg aaagaccctt ttctcatata agacgcgcca cagaagaatg cgcacgacaa 608401 cggactattt tagattatat aatggcgcgt gtgatgctgc tttaatcatg ttgcatagac 608461 catgcaatta cactaaaaat ataaaacaag gagccctgga cagaacttgg tagtgtgcaa 608521 acgagtaagt gaagatgata gtacattata tacgaagctc ttagtaagct catactagat 608581 gcgaaacgat ggatacgtca gaaaaataac aaaaataaaa tataatcatt aatgatgttt 608641 taactcgaca agcccctttc agagctgcca ttaccctaag aaccttgcaa agagaataaa 608701 cttgaatttc gtaaagtgcc acgaacagtg tccatattct tacacgagat attctgtgaa 608761 gagttattgc ataaatacgg aagaactaaa tactagaaat aatcccaagc tagaatataa 608821 acgtctcaca tacctaaagc cactccttcg tattggctag acgtatttac atacagagca 608881 tcgtcacttc tatttggatc cttgtcattg aagtattcgt ccacatgcat caacaaccaa 608941 accaagaagt cttcggtttg tttgattaaa agctgacagc tttgtagatc cattgtagta 609001 gacgagatca gctctggtaa aacacttatc aaccttaaca gatggatagc cccataaatt 609061 ctaattggta ctagtggctt ttgatccttc gatgattttt tcagaagttc gtcatattgc 609121 agccgttcca acctatataa aagcatatta cccaggcact tgtcaaaata caacttgaga 609181 ccggcacagt attcgctcaa ctgtgactgg gaccctggcg attccaattc ttgactcact 609241 tcatgttcgt atttattcag taccatctct accgtcacat cagcgggtag tctgcaaatt 609301 tttttgtcct tcgttacgta ttcccaatcg tcgactaaca cgctcttcaa ttttatggga 609361 atttgaaggg aaatcttggg ggttggatag ccggcaatat gatgtagcat atttggcgat 609421 agcgaagaag atcttctgcg gtcatcattc ccattttggt cggatgacga gcgcaaagag 609481 ctgccaggat ggagggaatt agcggaactt cttccgcttt tcctgccgct cactgaagat 609541 gttaaaaaac tctgtgaagt gctcttactt atactagcat tcgagcggct gtctcccttt 609601 ctttttccac cattactagg ccctcccaga ctagtggaga gcttcttttt tttctgctgt 609661 tccagtaacg atttcttagc ttctttcgcc tcgttcgcca gtcttttttt catggcaata 609721 ttctcttcat tgtaggcccg tatcctatca tatccaaccc actcatccca actcgacttc 609781 cagccttggt aatgtatgaa aaaacacttc ccattaatga tctcttctgg aatgctttca 609841 tcttctccca gcttttgtgg ctttatttcc ttagttgctt gtgaactacc acctggcttg 609901 tcattaggaa tgctggtata cattttcgaa gatggatccc atattttcaa gatctttgct 609961 tcatacataa gaggaccatg gaatgccaga caccgcccac cgagcgcaaa ttcctgctcc 610021 aaatcaacca ttatacgttc ttcaataggg taaatccagt gacgaggcct cacagatgct 610081 aatgcaaaat gctatatgct tttaacgact gttttgcaat ataccctttt acgtttctgg 610141 tcgggatttc ggatgcatct ttattttcat ctttcgtgaa atgcgatatg tggcgatcgc 610201 cggaggaacg gcccccaatc ttcgccacct ttttctatca gcatcggttg gttagtaatc 610261 tcgaatcaca tggtacctct ttcttcgagg agtggtagct cctgtacgct gtagcggtag 610321 tgaaaaggca atatatcgga gttggtgaag tgagttaaat ctctaccttg cgtttttgat 610381 aagtaaaaag caagcacagc ttaaaggata aacaggattt tattgaagca atttttaatt 610441 ataatacatt gtggatagaa cgaaaacaga gacgtgatag atgaacgttt caaaaatact 610501 tgtgtcgccc acggtcacga caaatgtttt acgcatattt gctcccaggc tacctcaaat 610561 cggtgcttct ttgttagttc aaaaaaaatg ggccttaaga tcaaagaagt tctaccgttt 610621 ttattctgaa aagaatagcg gtgaaatgcc tcctaagaag gaagctgata gctctggaaa 610681 ggcatccaat aaatccacga tatcttcaat cgacaattcg caaccaccac ctccatcgaa 610741 cactaatgat aaaaccaaac aagcgaacgt agctgtgtca catgctatgc tagcaactag 610801 agaacaagag gccaataaag acttaacgag tcctgatgca caagcagcct tttacaaact 610861 tctcttacaa tcaaactacc cgcaatacgt ggtctctagg tttgagaccc ccggtattgc 610921 gtcatcgcct gaatgcatgg aactgtacat ggaggccctg cagaggatag gcagacactc 610981 ggaggctgat gccgttagac aaaacctact gacagccagc tctgctggcg cagttaaccc 611041 atcattggcg tcatcttcat caaaccagtc aggttatcat ggtaactttc catcgatgta 611101 ttctccgctt tatggatctc gcaaagagcc actacatgtt gtcgtatctg aatcaacttt 611161 tactgttgta tcgagatggg taaagtggct gcttgttttc ggtatcttaa cctactcttt 611221 ttctgaaggt tttaaataca tcacagaaaa tacaacgcta ctaaagtcgt cagaagtagc 611281 cgacaaatca gttgatgtag ctaagacaaa tgttaaattt gatgatgtct gcggttgtga 611341 tgaggcccgt gcggaattgg aagaaattgt tgatttcctg aaagatccaa ctaagtacga 611401 gtccttgggt ggtaaactac caaagggtgt actgttgact ggacctcctg gtacaggtaa 611461 aactttgttg gctagggcca ctgccggaga ggctggtgta gattttttct ttatgtcagg 611521 ttctgaattt gatgaagttt acgtcggtgt tggtgctaaa cgtatccgtg atttgtttgc 611581 tcaagcgcgt tctcgtgcac cagctattat ttttattgat gaattagatg ccatcggtgg 611641 taagcgtaat ccaaaggacc aagcttacgc caaacaaacg ttgaatcagt tattggtcga 611701 attagatggt ttctcacaaa caagtggaat tattattatt ggtgccacaa atttccctga 611761 ggctttagat aaggcgttaa ctagaccagg tagatttgat aaggttgtga atgtggattt 611821 gccagatgtt cgtggtcgtg ctgatatttt aaagcatcac atgaagaaga ttacattggc 611881 agacaatgtg gatccaacta ttattgcgcg tggtaccccc ggtttatcag gcgctgagct 611941 ggcaaattta gtcaaccaag cagcagttta cgcgtgtcaa aaaaatgctg tttccgttga 612001 tatgtcccac ttcgagtggg ctaaggataa gatattgatg ggtgctgaga gaaagactat 612061 ggtcttaaca gatgcagcca gaaaggccac tgctttccac gaggctggac atgccattat 612121 ggccaaatac accaatggtg ctaccccgct atacaaggcc acgatattgc ctagaggtag 612181 ggcattgggt attacttttc aattgccaga aatggataag gtcgacatca ccaaaaggga 612241 gtgtcaagcc agactggacg tgtgcatggg gggcaaaatt gcagaagaat taatttatgg 612301 taaagataac accacaagtg gttgtgggtc tgacttgcaa agcgccaccg gcacagcaag 612361 ggctatggtt actcaatatg gtatgagtga tgatgtaggt cccgttaact tgtcagaaaa 612421 ttgggaatct tggtctaata agattcgcga tattgctgat aatgaagtga ttgaactttt 612481 gaaggactcc gaggaaagag caagaagact attaactaag aaaaatgttg agctacatag 612541 acttgcgcaa ggtcttattg aatatgaaac tctagatgcc cacgaaatcg aacaagtttg 612601 taaaggtgaa aaactggaca aactgaaaac ttccaccaat acagtcgtag aaggaccaga 612661 cagtgatgaa cgtaaagata taggcgatga taaacccaaa attcctacaa tgttaaatgc 612721 atgattttat tctaagaagt taaacgtatg aaggaaccta cctcaagacc gagaatgctt 612781 tgttcttttc tggtcggttt cgcttttgct tcataacacc agcaatgaag catgatcgcg 612841 ggaaactttc agaatctaca tcttctcctg gtcagcttga aacttcagat tattcgtaag 612901 gagaaattat aatattattt ctgtgataag aaaagaggca ttaagcttgg gtatttgcga 612961 caaaatactt caggataacc gatgatcgca agtgggttat taatttcttt catcccttaa 613021 ccaaccgtcg ctttccccca gtgacaagcc ttaaaaaagt cacaccatgg aacggagtat 613081 cgttgatgat taaaccaatc attaatcttt cataaaagtt aagataaaag cacttgttga 613141 tatatatagg tacatgtgta tcaatacgcc atacattgta aatagaatat tcaatggata 613201 aacgtgtgta gcaaaaataa tcacattgta gcgctagtta gcaatttact cattgtcaca 613261 ttttttgcag tatatattca tggcatgaaa taatataaaa tggcgccggt ctatatacct 613321 atgcatctta atctatatat atatataaaa cagaaaccta cggtaacaga gctgtttcat 613381 gttttttgct ttttctcaac ggtggacgaa gtatcttctc cattcaactt cctttttaat 613441 ttctgaatca gtgttgatgg attttgacaa taatagtttt ttgccgcaat tttcttggcc 613501 tcttcagtac tcggaggttt acaatcttca ataatacttt tacactcgcg tattatggtt 613561 agtaacttcg cggagtctat cgaatattct tcgctctctg tggacttctc tttgtttttc 613621 tcagttgtac tggcatcatt ttgtggttct tctttttcgt ttcccggtac tgattcctgg 613681 ctaccttctc tgctgggaaa ttttgtttct aaataccttg tgaccaaggc ttcatcctca 613741 atcaataatg ttgctagtgt tatttggggt ggagtgtaga aatatacgac atcggttaat 613801 aatgcggcag ttattctctt cttacaccta tcgtatattt ggcccatgta atttaaatca 613861 accttaccat aaaggacgtt ctggatatct aagaaaaacc catgaagcgg tttgtaagga 613921 tgatggttca acagtgaaaa tttcaatgat tctaacaact taaactcgaa tttgagaaca 613981 ctatctctag tagatttggc cttttgagca aacgagtcca cgctaataaa atagttctcc 614041 gatttgcagg ctagaaagat agtagtatgt acaatacttt taggatctat ttgcataaca 614101 gaattttcta agaaaaaacg cctaaaaaag gatatcgcag tggccactac ttcggttggc 614161 aaatttagat gctgtgctat tacctgaact ttttttgcgt agaaattcac caaatcgagt 614221 tcttcttcca ttgtcaaagg gatagccttt gcttctagta cttttatttc ttcttctgtt 614281 aaattgtgtg cttctctaaa ttttaataaa ttttcctcaa tgtaagcaat cgctcgggca 614341 ttggtatcta cccttttctc ctgaagttga tctttagtgt atgaccacat tctatactga 614401 gaagagtgcc tatataaatc atcgtcagaa attcttttgt agttcggtgg cttgttattc 614461 tcatcagccg attttaattt tgcctctttt tcttttgctg acatggtagc agaaggagta 614521 tctaatgtac tctttccatt tagttgaata tccgtcattc tatcaatatc tgtgcagcac 614581 agtattttcc tctcttaaac ttaatattca ctcatttgtt tgagatcttt cttaatataa 614641 aaactgtgtt aagatcaaat ttattacccg gattgtgaac ggcttaaaca acgaagggat 614701 accgcaggaa atgagaggcc ctttcttctc tggatggcaa acagttcgtg ctatcaaagt 614761 ctgtaccaag gttatttcac tcttcaagcc agcaataact actttctttc aggtcacctc 614821 tcagccgtca cgtctctagc tgaagctttg ttattctcgc ttcactaaaa acaagtgtat 614881 ctacaatatt taccagtcta ttcgtatatc ccttatcatt ctttttcaat aagggcaaat 614941 acttcggaaa aagaaaggaa cattcatctt gattctagcc gtaaagctat cacgttcact 615001 ctaagcaagc ggaaagttga gcaaaatcaa cgaacaatct gagtcagcaa ggcagtacaa 615061 gcatctcttc tttgcccctc aaaatttatt tcctttttgg tatagtctta cttccaagtc 615121 caagcaagca ctacgtatca cgacaaacca acagccgcgc cgtttttata ttcggaaaga 615181 gaattcttgt cgttattgaa taataataac aaaatttctc cacttttcac catattacca 615241 ctcccttttt ttcaagtaaa aaaaaaaaaa aaaagaatct tattgctcct taaaaaagga 615301 ttcatcagtc ctttatgaga gcctgctagt atcacctaat attgcatctg tttttaccga 615361 aatttcctca ttccaataat gaaaagaata agatcgcttt ggttcaatgc ggaggcttct 615421 tattcaaacc ttaacaattc tcctagtttg aggaacaaaa atagtaccgg taataactct 615481 cgctctaaaa attatcgttc tttctcaagg tttgacttga tcaactctat acttttactg 615541 atgatgctat ttttattagc tatcttcgtc actgcattat atttaacaaa gagttccagg 615601 cttacatact cacatgcctc gagggctgcc ctatttaacc ctctgggtgt gatatcgccg 615661 tcattgggaa atcatacgtt gaactacgat ccagaagcaa gggaatcttc taaaaaactt 615721 tatgaactcc tttctgattt caacacggca tattatgatg atgagaacat gattttggga 615781 agtaacttgt tctcaaagaa tacatactcg agacaaccat atgttgctaa cggttatata 615841 ggtagtcgta ttcccaatat tgggttcggc tatgccttag acaccctgaa tttttacaca 615901 gacgcaccag gcgctttgaa taacggttgg cccttaagaa atcatagatt tgccggtgcg 615961 tttgtatcgg acttttattg tctacaacca aaactaaatt caacaaactt cccagaattg 616021 gatgatgtag gatattccac tgtcatttca tctattccac aatggaccaa tctacagttc 616081 tcattagtga atgattctaa gtggttcaat ccacaaaatg ttacgttgga tgacgtaact 616141 aattatagcc aaaacttatc aatgaaggat ggtatcgtaa ctacggagtt agattggcta 616201 aacagtcaaa tacatgttaa aagtgaaatc tgggcacatc ggcacattca tccactggga 616261 gtggtttctt tggaaatttc cctgaatacg gaccatttac cttcggattt tgattcatta 616321 gatgttaata tatgggatat acttgatttc aacacatcac ataggactgt tctacatagc 616381 acgggaacag acgaaaaaaa taatgcggtt ttcatgattg ttcagccaga taacgttcca 616441 tcttctaatt gcgctattta ctcaacgtgt actgtaaagt atgaaaattc caccaatcca 616501 ataaattcta gtgaatcttt tgaagaaaaa gatgtttctt ctaatattta taatgttatt 616561 ttgacagagg accaacccaa gataatcgtt cataagtatg ttggtattat gtctactgag 616621 ttcaataaga acaaagaaca acaagacaat actaatattg gtttggccaa aatgatagct 616681 ctaaacagta aaggcaatta cgagaagctt ctgtcaagtc acaaacgtgc gtggtatgac 616741 ctttacaacg acgccttcat tgaaattcct tctgacagtc ttttagaaat gacagcaaga 616801 tcgtccctat tccatttact agcaaataca agagattaca atgtctcgag cgataggggt 616861 cttcccgtgg gagtttctgg tttgtcatca gattcctatg gtggtatggt gttctgggac 616921 gcagatatat ggatggaacc tgccctattg cctttcttcc caaatgtggc tcaaaatatg 616981 aataattaca gaaatgctac acattcgcag gcaaagttaa atgcagagaa atatggatac 617041 cccggagcaa tatacccctg gacatctggt aagtacgcta attgtacttc tacgggacct 617101 tgtgtcgatt acgaatacca tattaacgtt gatgtcgcta tggcctcctt ttccatatac 617161 ttgaatggac acgaagggat tgatgacgag tatctgagat atactacatg gccaattatc 617221 aaaaacgcag cccaattttt tactgcttat gttaagtaca attcttccct aggattgtat 617281 gaaacatata atttgacaga tcccgacgag tttgctaatc acatcaataa cggggctttc 617341 acgaatgctg gcattaaaac acttctaaag tgggcaacag acattggcaa tcatctcggc 617401 gaggtcgttg accccaaatg gagtgaaatt tccaaagata tttatatccc tagatcctca 617461 tctaacatca ctttggaata ttctggtatg aatagctcag tggagattaa acaggcggat 617521 gtgactttaa tggtttaccc acttggatat atcaatgatg aatccatatt gaacaatgca 617581 attaaagatc tttattatta ttcagaaaga cagtctgcgt ctgggcctgc aatgacatat 617641 ccggtttttg tggccgcagc tgctggtctg ctgaatcacg gctcttcttc tcaaagttac 617701 ttatataaat cggttcttcc atacttacgg gctcctttcg ctcaatttag tgagcaatca 617761 gacgacaact ttttaacaaa cggattaacc cagccagcat tccccttttt aacagctaac 617821 ggtggatttc tacagagcat tctgtttggg ttaacaggaa tccgatattc ttatgaggtt 617881 gatccagata ctaaaaaaat taaccgtttg ttaaggttca atccaataga actaccgttg 617941 ctccctggtg gtatcgctat tagaaacttc aaatatatga accaagtttt agatataata 618001 attgacgacc acaatggtac gattgttcat aaatcaggag atgttcctat tcatataaag 618061 ataccaaaca gatctctaat acatgaccag gatatcaact tctataatgg ttccgaaaac 618121 gaaagaaaac caaatctaga gcgtagagac gtcgaccgtg ttggtgatcc aatgaggatg 618181 gataggtatg gtacctatta tcttttaaaa ccgaaacaag agcttacagt ccaactgttc 618241 aagcctggct taaacgcaag aaacaacata gcggaaaata agcaaataac aaacttgacg 618301 gccggcgttc ctggtgacgt tgcattctct gctctagatg ggaataatta cacgcattgg 618361 caacccttag acaaaattca ccgtgcgaag ctattgattg atttaggtga atacaacgag 618421 aaagagatta ccaagggaat gattctttgg gggcagaggc ccgcaaaaaa catttccata 618481 tctattttgc ctcattctga aaaagtcgaa aatttatttg cgaacgtgac agaaattatg 618541 caaaattcgg gaaatgatca acttcttaat gaaaccattg gtcagctttt agataatgcc 618601 ggaattcctg tcgagaacgt tattgatttt gatggcatag aacaagagga tgatgaatct 618661 ttggatgatg tgcaagcctt attgcactgg aagaaggaag acttagccaa gctaattgaa 618721 caaataccca gacttaactt tctaaaaaga aaatttgtga aaattctgga taacgtgcca 618781 gtgagcccaa gtgagccata ctacgaagca agtcgcaacc agtcgttaat cgagatatta 618841 cccagtaata gaacgacttt cactattgat tatgataaat tgcaggtggg tgataaaggg 618901 aacacagatt ggaggaaaac aagatacata gttgtggcag tacaaggagt gtatgatgat 618961 tatgatgatg ataacaaagg agctacaatc aaggaaattg ttctcaatga ttaaatgaaa 619021 tgatgcatat aagtagcgct ttttttaata ttataagttt ggataaaagt taccaatttt 619081 ttcgtaggat atatatttta aaggcactat attgaaaata tcatgcatgc ttatataaaa 619141 gctttttttt ttctataggg tgacatttag gagcaataat ttttactaca agcttttttt 619201 gcaccttata tagtagtgac cttgaaattg gtcttttgca ccagcgtact ttaattccac 619261 taagtactgt ttagcagcct gttttccaga gcccacaaca gttttctata aaattttcac 619321 atgcattata tagacatgat ctacctacca atttgatctt cctgccattg agatcagttc 619381 tttcattaca ttgattgcac atttttaatt ggcgcctttt ctaatttttt gtatgagtcc 619441 atattaaaaa aatagacttc aaattcctac tagacgattc tgattccatc gggattacca 619501 ccagatttga tattggctct tctctcgtca gtagggtttg aacagaaata ttcctaaatt 619561 tctcgcaact taaattaaat ttgcaacgat aatgtttgca tacattttta tattctagat 619621 tcaatacatt agaggtaact tgatgtagcg ccaatctgaa aatacagaag cctactaggc 619681 aaatatttaa agctctatat actattcacg aaagaaaaac gtactttgta taaattgaag 619741 aaaatgagtt tgtgttagtt gggtcctgcc atttggtatc ctgaaggttt tctcaaggtg 619801 gggtgggcta atctacagga atagtttata gtaattgtgt gttaagaagt attttggctt 619861 taaatgacgt cccccacaaa tttattactt caggtgtata atgtattcac aaatatgttc 619921 gtttcttttt tgctcttcat cgtccccagt ttttcctcac ccttacaaaa caaaaacggc 619981 aggaaaaggg tcctatgtaa attaagcaaa cactgcgggg tagaacctaa attttaatgt 620041 atttttttac aatccaacca agattaaacc aattgccgag ctttttcctt tctcggtgaa 620101 acaaaccttt acaaaagata cgccagagta aacgcattcc tacaaaaaat gaaagatctt 620161 cattatttac actcttgtag cccactaatc aattggtttc gcaacattgt tcaaaggcag 620221 tggtttcttt ttccctgagt atcctactat agtacaaaaa aaaaaaaaaa gagtgaaaaa 620281 atcagaagag aaaattatat cgattataaa tttttcaagt acatcgtcta tcgaagctaa 620341 agacttgaat aattaaattt ctggaaatgg gacaagtgta cttatcaaca acgaataagg 620401 tatagcaaag tttagagaat tattttaatt atccctataa aatgaaaccg atatttgaga 620461 tttgtttggg cctttttctc tcccatgagc agtgaagcct acagcagaac cgtcccaatt 620521 ttcgtcggtg attttttctg aaatttgata aagctgagac ttaaaattac ctgatatttt 620581 tctaatgttt gatattttct ggaaaacgcc attagcaatt ccttggctgt tttcgtttaa 620641 attgccctgt atgtccgata atttataatt tgtgaactca tttgaagcgc cttttgtata 620701 acaaatctgc tgggccaagc ctgggaaagg cagagccgtc ttctcgccaa gtttgagaat 620761 caaacagttt tggtttagtt cacttcctga agtattcata tttactccta agtataggtc 620821 gagaggttca aatgttgttt tgattttttc attcacataa tttgaaggta gctcgacgta 620881 ttttggttta attaggtcat ataacctttg cggttcattg ataccatcat tttcgagctt 620941 gttgataagc tcgatgatta atgaaaacat taagattaca actcctagcc cacaggatat 621001 catattggcc ggattttcac ctacagaaaa acatgatacc atagtttgaa ttacttgaag 621061 tgttagttta gtgtcatcca gtttcttttc actaacagat tttgtagcgg caggtgcagg 621121 tgcagtagaa gttgatgtca ccgtttcata tacagttttg atgattgtaa cagtatctat 621181 catgtcatca tcatggaatg caaaaagaag acccaggagt gggacgaacg aagcaagtat 621241 tctgtaaata ccaaccattt ctttttatct ggcgctttat atgtttatga atagtacgtt 621301 atgatgattg tttttttaca aatgtttgtg aattacacta atggtaattc cctctttagt 621361 tagaagtaat ggaaaattag tactttctaa ttcttgtgat caacgctttt tcaacgttgc 621421 catcatcaac agaatctcga tctgctagcc aacatcaaaa agttgtttgc cgcacatcat 621481 gtaaccgaac tttcagtacc acaaaaacta atatgcacgg cgcttgaaaa gtgctttaat 621541 tttgtaaact attttgtttt gtaaatttct aggcagttga ggctaccgtc gtgaccacag 621601 aaagaaaaca tcttcaaaac actttagtga ctgtccatat agccgccgaa gttagtcgct 621661 gatataattt gaaacctaca ttattatttg ttcgtttgga agacacgtta ggtttagtat 621721 caataaactt cccatccgaa acacttattc tactagtgtg tttcataatg cgtaagccag 621781 cacgtatata ttcatctcaa tttgttacac acttaacata ctatataatt cctgagaaaa 621841 tgcccagctc ataaacatcg gtagtccaat tcaagaacgg gggaactgaa tttgggagta 621901 atcaaaaaaa aaaaaagacg ttacttcatc gtttttgttg tcattgtaca cttctttcat 621961 ttcttttcag atttaacttc tctgtccgta gtcggcaaat aacggtcctt taaatgcaag 622021 ggatcatcaa gagattttga aaaactgtgg agccagatat ttatttgtca actttggaca 622081 tctaccttag tctgtctgct tccctctttt tgacctcttt tagtaaactc tgaggtggga 622141 tgactgactc tgacggagaa agtatgtaga tatctcaaga aagtatcagt ccacgatata 622201 gtaggaaata ttatacaata cgtaatggaa gcaaagtgtg cttccatgag ttttagacaa 622261 atttatgtcc ctaaaacttc gaacttttaa cgggaacaat tttggccgtg ataaattctt 622321 ttccaacgct tatattgatt atccgttatt ggttttttgt tggagacatt aaaagatggc 622381 caatggcgta agaaaatttt gaaaaaaagt cagacattca agttgaaaaa ctccttcatc 622441 ttcctacttg agtctatatt ttcattgata tttccataag agaaggagca gtcaagttca 622501 agaaccaact ttccgcagtt ggcaggtcga aaaaataaat gcgaattctg tggatcgaac 622561 acaggacctc cagataactt gaccgaagtt ttttcttcag tctggcgctc tcccaactga 622621 gctaaatccg catatcagaa tgaaataaac aagcattctt gtgctttata aatggtccaa 622681 gcgtctaact tttaaagagt acattctaaa agtaagagac gaagacaaca ttataataat 622741 tttctcaaga catatatgtt tcaccggcac gttttgtttt gtcccctttt attttgagcc 622801 tgaatactat gctttataaa actttaatgc gctcaacaag tgcaccttcc aacggaaaaa 622861 aagaaattca acagggagcg atgccatcat cacatgcacg ttttcaagta tttataagac 622921 ttgctacttg ctcgtccatt catgacttta atgaggttct aatttattgg tgcaactctt 622981 caaactagct gcccaatcag tgctggaatg agtgccaaga caagcgacaa accctgtcaa 623041 tctcctgaaa aacaaaaatt aagtgcttga gaagaccttc agaagagttg catagatagg 623101 atgggtgagc gcaattacta gttacgcagt aagtaggtta tatggctgct ggaggggcag 623161 tactgattta atcacaatcc ggattaaact tcctcctgaa aaaaaaaaaa ctacatcaag 623221 tcaaaagatt ttcattcact ctttggaagg ctgtgtggca ttctaacctt tattttttta 623281 tcaccattct cgaattttcg tggttcgctt tcttagcgcc gttattctct cttcttgtcc 623341 acgtcaaagg gagtatgcgt aacccctttc aaggttgaac gaaaaaaaaa aaaatatgtc 623401 cttcaaaatt ttttttgatt taaaactaaa aaacattccc ttgaagcttg ttattccgaa 623461 agaaagaatc taaaattgca attggtagtg aaaacaaata aacaaagaca taaccgcact 623521 ccaatcatgt ccgaatatgc atctagtatt cactctcaaa tgaaacaatt cgataccgta 623581 tgtaagatgg ttttattggt tccatcgtca tcatggttca aacagccaaa tgacccgaca 623641 cacgtaaccg aagcagttat actaacaaga aagctaattt tcaccctcct tgctacattt 623701 ttttctacag aagtactctg gtaatagaat tttacagcaa ttagaaaata aaactaattt 623761 gcctaaatct tatttagttg ctggtttagg tttcgcttat ctccttttga tttttattaa 623821 cgtcggaggt gtaggtgaaa ttctttccaa ttttgctggg tttgtgttgc cagcatattt 623881 atcgttggtt gctttgaaga caccaacgtc caccgatgac acacaactct tgacctactg 623941 gattgtcttt tcatttttga gtgtcattga attctggtcc aaggcaattc tatatttgat 624001 tccattctac tggtttttga aaaccgtttt cttaatctac attgccttgc ctcaaactgg 624061 tggcgctaga atgatctatc aaaagatcgt agccccattg accgacagat atatcctaag 624121 agatgttagc aagacagaaa aggatgaaat tagagcttcc gtcaatgagg cttctaaggc 624181 tacaggtgct tctgttcatt aagaggcaac tcacctatat cctcaaatca aactctcgtt 624241 tttgttctct ttgttatcta ttctattgag agcatataag tacatatgtt attagttgtt 624301 atatatcgct acttaacata taaaatattt tggagtcgtt tatggtgtcc cagaagatag 624361 catttctatt catcgtgttg tgtcgtgacg tgtctcttga tatgcgcgac agaccatcca 624421 acgcaaggtc attaatcatg ttatgttctg taattttaaa ggcatttttt atagagtttc 624481 atcgaatttg tgatcgaact gttcattggt gatagatgaa gagccattta aatgaaaatc 624541 caacttaact cttaacttca gtttcccaga tccagaaatt ttcaatgact gcttgcaaat 624601 ttggctggcg tttattgtgg aagatggata taactggcct agtgttagct tttgagcttt 624661 aggaacggca cagaaagttt ttaagtcaga tattaaagac tttgcctgaa aatataaatc 624721 caaatgtgct aatccagagt ttgcagagag caaggaagca tatacattca gtgaggaact 624781 gtcatatatc ttgttggcat ccaatggtaa ggtgacacct gagtttgcct ccactgccga 624841 cgaatgattg attgattctt ccttgttcgc atttttgggc acctgagcaa tgtcattctt 624901 ctctccaaaa atctcttcta atatgtcaat tggtttcaca ttgtcaccag tagaagcctt 624961 gctttcagcc ttgctatcct cacccaataa atctgacagc agatcaactg gttcgttgga 625021 gataaggttt ttcgatagag cttttccatt atcctgttcc tcggtaattt tttcaaattt 625081 aggcattgtt tctaaaatga tcttcttcac agaaattgac tgattgaaaa atatctcgta 625141 ttgattgctt ttcatttgca gtgataaatc agtggaatcc gtgtagctca atatcagttg 625201 tcttagtttt tcaatatttt tcgcgtcatg gaacctcaca gataatttta atgctgctgt 625261 taaaatgtaa ttgattatct tcagattcgt tgctgtgtag agttcttgca aagttagtaa 625321 gtaatcagta atagatgact cattgattat gtctgcacca tttttattgc cctcgttgag 625381 tactaaatcg ccatattcgc caatgcacca aatcaaaacc aactgccaac caatattttc 625441 ctcggaaatc tccgctgatg ttccatttag tgaaattgtc agcattttcc gtaaaaattc 625501 agatttgtcg gataactggc tcgtattatt tattatgatt agaatatcat taattttttc 625561 atagttgata aacgatccca ctaattttaa gatattaaag aaaacatcta atttccagct 625621 ttcatctttg acaacgcggg tatcaaaagt gtcaattaag tgatctatag tgtatattat 625681 gagatctttt gaatcttcat cctgttttgc caaaaatttc atcaattcgt taaccaattc 625741 cactaaattt gaatcgtcca agatggcgaa gctcaactct aacgctctca tgcggatcga 625801 cacatcggta tcctgcagac aatgagaaat gaattttcta tgcctttgta ctgcggtagg 625861 ctcttgggga acaactttta ataaggtgtt taatgaaacg tatttagtat tattatcttt 625921 tcctgcaaga aacttggcca agatgttaat accaaggaca cgtagaggct ggttcaaatc 625981 caacgaaaag atcgtcttca cggtctcata aagaatggcc tgtccgctgt ttttcgttga 626041 atccgtattc gtcgcaatac gagtcaataa atcgcagaaa ttatctttgt agtccaaaac 626101 attgttcgaa tttaagagct caccaacttg aaagtatagt tttaaagtgt aaattatttc 626161 acactgcaga aatgggtcac aaataccttg gacatcatat ccaggttcaa tatttttaga 626221 attcatattt tccaaacgaa tgaaaaaatc acgcaaaagt aaagataatg gagacaagat 626281 gtcattgctg taatcaatac cgtcttcatc ttcatcctca tctttttttc tgttcaatcc 626341 aattaacaaa atagattgta tgattttcgt aacgcctaaa agtacaccgt gagtacatat 626401 tgaatgacta gacaatatct tagtaatgtc ttcgatgttg aagatttcta aaagtgaaac 626461 gtctttgaaa attagtttgg cagcacattg aagcgctttt ttcaagagga aagggtctct 626521 tgaatttttg atgatatttt cgacgtctgg gtataaatct ctggctaatt caggggagct 626581 caaaaagcct aatgaggtta gtgcaagtga cactgcatat ttgttgggat gatgcaaatc 626641 gttgttcaac atgttcgtta agagtgtcaa taaatcttca gattcgtcca acaataaagt 626701 tgcggccaga tagcctaatc ttttatcgac aaaatcgtca gaagcaatta aattgataga 626761 ctccacctga ccgaaatgtg tcttttcccc tagaatgtat agatacagaa gtttctggat 626821 atttactcgc cttttttcat gtggtagatg gtcatctctc aattttgtcc taattttagc 626881 agattgtttc gttataattg ccctttcatc tgccagtgtt ttggcaccac gaacgtcttt 626941 gataaagctt ctcaacgaag agcccattat ggtgttcagg tctttctcgt tgctaaatca 627001 agatggtcaa tatttcttct ccaatattag cagtataaaa tctcgaaaaa gtatgattta 627061 gttgtaattc tcatatggcc aagcccacta aattcagtga atacaaacag ctaaggacgt 627121 caaaactcag agtcgggtaa tcttcatttg aatttttttt ctcttaaggt agataacacc 627181 aaagaaaagc aatcagtagc aaaatatgga ctttaacgct gtcagttcca attgagaaat 627241 atcgtaaaga aagttagttg ttttcactcg caacctctct accttcgtgg cctaaaatag 627301 atttaaataa tcgaataaac ggtttgttct tatatgtgat accctctttc accaccttcc 627361 tgtagcccca gttggtatta cttgtcccaa cctcattcct ctttccatta tcaattaatc 627421 ggtttgtgtt gttcgtagca ggaccacact tccggaatta tatacattta catgtatata 627481 gagaagaaag cttcggcggc taaagaatag aaccatctat tacccgctcg cccggtcgtt 627541 tggatgcgtg ggtggtatag tttctttttt ttcattttaa gggataccgc tccccacgta 627601 ccccacgacc agccctagtg gaataagaaa tgcaaaatcc ggggttggcg cagcgattct 627661 gcacggccaa accctgggct tctttatttt gtagatctgc caaatgatgg ctatgcctta 627721 ctcggtatca catggaaaag acccccggct tattgaatcc cgtctcccgt tccctgcata 627781 gttgtcacgg tttggactat atatatcgtc gtttctctgt tttatttatt atgatggctc 627841 tccaagggta atcagtcaga ctagtaagca aagtcaatca tgcaatctac tgtcccaata 627901 gcaattgcga gcaacggcaa caagagagat gtcgtccaga acgtttctgc aggcgacgag 627961 ggtgatatat tgcaaaggct agcccgtaac agagagatga tttctacctc cctctcgcca 628021 caaaaatcgt caggatttag tggtagaagg aggtcatcta gtgttaggga cgccctttct 628081 tctttttttg gaactggtaa tagtccaaca tctagtatgg acgattattc caatttgatg 628141 aaccgtaact attctaccgc atcaactgcc atgtgtaggg ggaacagttt tccttcagat 628201 gttggcacta aggcttacaa tattacggga tcttaccaac cggataggca caggaattct 628261 gttccgtata ccaccataga ccagttacac acaaggcaag acaccgggtt gaggagagag 628321 tcagatccag tcgcggcaaa acaaatatct agtaataatg atattgttag gtcattcata 628381 acacatcatg ctagtaatag cactatgttt attaataggg tgctatcgga ctatttagcg 628441 gatcgtggtt tcatcaagca aacaccgtta tataataaga aaagtgtgct ggaaatttcc 628501 attgcaacaa gtgcagaatc agttttcttg ccaactacaa aaagtgatga aacagagtat 628561 ctatcactga ttcatggttc tttaaatcag gcgcgaacac agcctgtcgg gtccactaac 628621 actgcagaaa gtgatttcct cccttcatgt cctacgatgg acactttgaa tgaaaacaat 628681 gatttatcac tatttccgtt acatacacag cgaaccagcc cctctaatac agcaaggaca 628741 ggtaatgcta tggatacaag caattctgat cgtgcttctc cggcctcgaa caataacaca 628801 acagatgcgg attcctttgt tgcgagtggc aataacaacc ctatgaataa taacaattct 628861 cccgcgagaa acagacatcc taattctcac tcgcgttctc ttcctaatgc ttggaatagc 628921 caaatgcctt cattcagctt tgcattgata ttttccctga ataaatcaac taccctttct 628981 gatattaaag tagaactcac ttctaacgtg agagtggtgt ggttcaatgg tcttccccct 629041 accaagaatg ttaacgagga atgctataat ataggttctt tggactggac cttaaatgca 629101 gacaacttta atcttttcat tccgcaaggc gcaaagtctc ctcttgatat cgttgaaaat 629161 cattccaata acaggaaatt gaaagtgctc cagaaattat cgatgaggaa acgccgttct 629221 ttctcgaata aagcagttct tagggaaaat atattaaaca atttaaatgc ctcgaattct 629281 acgaacaagt taaatgctgg tgtttatgtc tttactatcc ccatagtgct tgccagtcgt 629341 attcctgaat cgctttacta cccatcagcg agggtatcct acagcttaag attagcgaca 629401 aaattgaagg atgaacatac acagttggtt gcatcacggc cacgttcttc ttctatctct 629461 tctcctcaaa aactgcgttc atattcctgt tctgattctt atgaatattc tcaaattgat 629521 gacaccatag aaggagaaac ctacaataac gacaaaaatt ctactggaaa aatcgcattt 629581 ccctcctcat ggttaaaaag tgcgaagggg cgcttaaaaa ggaataattc taacggaagg 629641 tcagataata atggcgcatc ttctagtggt ttagcgatgc aacatgattc tgaagacact 629701 ataaatttac agtacccgct taatttggtg agaactccgc cagaaatctc tgtcactaca 629761 gcaaataagc cactttacat taacaaggtt tgggagaatt gtctttctta tgaaatttca 629821 ttcgcccaaa agtatgtgcc cttgaatggt gaaattccaa tcacaattaa agtggcacct 629881 ctagtaaaaa gtcttagtgt caagagaatt cgtgttagtt gtagagaaaa aatctcctac 629941 aggagtaaag actatcaata tgattttgac cagttggatc cattggcttc agatccttgc 630001 aatccctatc atatgagata tttagtgaga aaaaagaagg acagaagctt gcctctattt 630061 gaggtggcct ctaaatgtac tagtgggcct tctattagag aggaagttgt caccaataca 630121 gttgatgata acttattagc ctacacttca tcaaaagaaa acaacaaaga tatcccattt 630181 tctgagtcct ttactgttaa aacgaagtta aaatttccaa aatattgtga agtggacgct 630241 accaaagctg caagtctacc accatatggt atcgatcttt tcgacccaat aaaagatcca 630301 actcagagtg agaacacctc taataacggc aatgtattgg gctttctagt gggtcgccct 630361 aacagggctt ccaagacagt tcataaaata ccgcaagaca agaatcataa tgaggtcaat 630421 gatacaaatg gaaactcgaa tacatctttg caaactagct cgaatgttcc cattcagcac 630481 tacacacggt tgaataaacc aagacgcggt ttatatttgg acagtatgca ttttaagaat 630541 atccaatgtt ctcataaatt agaaatcgtc ttgagggtta gcaaaactga tagtggtagc 630601 tcaaaaatca taaggcatta tgaagtaatt gttgatacac caatttattt gatttctgac 630661 ctttgtaaca cttcaaatat agacttaccg acttatgaca tggccaccac tgaatcttct 630721 aaagtcctgc caccaacttt tgaagaggca acatcagttt cagcatcacc aagatcttct 630781 gtatcttatt atcccgatga catttccatg caacagttga atttgtctag gtcgacttcc 630841 ctcgcaaatg gttacctgtc aaccttacat ccaaaaacaa ccgctgtttc ggactcgtct 630901 aacggtgccc caatccggga ccagcaagag caacaagcac gccccttgag gactgaagat 630961 tatgcgctac aaatggggaa tgaaaataac gcctatagca atatggacgg tttgctttcg 631021 caggatatct ttgaacagga gaccgcggcc acgctattta aaagagacat tgtcacaatg 631081 aactttaaca ataatatatt cacaccacgg tatagtccgc gcacttttac caataccgac 631141 tacaattata atgataatga taataatgat aatgatacag aggggcctgg tccaataatt 631201 catccgggtc ctgaaccacc aagatatgac gagatttcat cataaatatt aatatcttca 631261 ctttttttat aaacctcaca cacacatata tatatacatt tgtacaaata tgtacctgtc 631321 cgaactaact ttttttttcg tgtaatatac gtagaatata tgtctttcgg ctcatcgcaa 631381 attgtagcac cgaaaaaaat ggaagacgat aataataaac aagtttgaaa gtttgaaagc 631441 cgtgcagttt ttcaacgtat taggtttttt tattcaaata actttgacaa gggcgttgta 631501 cgacttagca cctaatgaat aggggatcat tagatgatgg gcctaaacta cgtgaagaaa 631561 agcacttcca agatttttat cctgatctta atgccgatac tttactgccg ttcatcgttc 631621 ccttagtgga aacaaaggat aacagcaccg atactgactc agatgatatt tcaaatcgga 631681 ataacagaga gatcgggagt gtcaaaagcg tacaaactaa agaattgatt ttcaagggga 631741 gagtcaccac tgaaccacta gtactgaaga agaacgaagt ggaatttcaa aaatgtaaaa 631801 taactacgaa tgagttaaaa ggtaagaaaa atccatactg cgttagattt aatgagagct 631861 ttatatccag gtactatcat ataaacaaag taagaaatag gaagagttat aaacaacaac 631921 aaaaagaatt cgatggtgtg gaggcaccct acttcaccaa attctctagt aaagaagccc 631981 cgaatattac tatttcgacg agtacaaaga gtgcaattca gaaattcgct agtatttcac 632041 ccaatcttgt taatttcaag cctcagtatg acatggatga acaggatgaa ttatatttgc 632101 actaccttaa taagaggtat tttaaagatc aaatgtctca cgaaatattt gaaattttaa 632161 tgactacact agaaactgaa tggttccata ttgaaaaaca tataccctca acgaatagtc 632221 tgattgctag gcataatatt ctaagggact gtaagaatta tgagctatat ggttctgatg 632281 atggaacagg tttatcgatg gaccaggcgt gtgcagtttg tttaggcaca gacagtgaca 632341 atctgaatac aattgtcttt tgtgatggat gcgatattgc tgtgcatcaa gaatgttacg 632401 gtataatttt tatcccggaa ggaaaatggt tatgtagacg atgtatgatc tcaaaaaata 632461 actttgccac ttgtctaatg tgtccaagtc atacaggtgc attcaaacaa acagacaccg 632521 gttcttgggt acataacatt tgtgctctat ggcttccaga gctatacttt tcaaacttac 632581 attatatgga acctatagaa ggcgttcaaa atgttagcgt atcacgatgg aaacttaact 632641 gctacatctg taaaaagaag atgggtgctt gcattcagtg ctttcaaaga aactgtttta 632701 cagcatatca tgtcacgtgt gcccgtcgag ctggtctcta catgagtaaa gggaaatgca 632761 ctattcaaga attggcctct aatcaattct cccaaaagta ttcagtcgaa agtttctgcc 632821 acaagcatgc acctagagga tggcaaacga gtatagaagg tattaataaa gctagaaaat 632881 acttctctct actctctaca ttacaaaccg aaactcctca gcataatgaa gctaatgata 632941 ggacaaattc aaaattcaac aaaacaattt ggaaaacacc taatcaaacg ccggtagcac 633001 cacatgtttt tgctgaaata ttgcaaaagg tcgttgattt ttttggctta gctaacccac 633061 cagcaggcgc atttgatatt tgcaaatatt ggtcaatgaa aagggagctt acaggaggta 633121 ccccattaac tgcctgtttt gaaaataatt cattggggtc cttaaccgag gaacaagtgc 633181 aaacaagaat agattttgcc aatgatcagc tcgaagactt gtaccggctc aaagagctga 633241 ctactttggt gaaaaagaga acacaagctt caaacagctt gtccagatcc cgaaagaagg 633301 tttttgatat agttaaatcg ccccaaaaat atcttttaaa aatcaatgta ctggatatct 633361 ttataaaatc tgaacaattc aaggctcttg aaagattggt tactgaacct aaattattgg 633421 ttattttaga aaagtgtaaa cattgtgatt ttgatactgt ccaaattttt aaggaggaaa 633481 ttatgcattt ttttgaggtt ttggaaactc tacccggtgc atcaagaata ctccaaactg 633541 tctcatcaaa ggcaaaagag caagtaacaa atttaattgg gctcatagaa catgtagata 633601 ttaagaagtt gctatccaga gattttataa taaatgatga caagatagaa gaaagaccat 633661 ggagtggccc ggtgattatg gaagaagaag gtttaagcga tgcagaagaa ctgagtgcag 633721 gggaacaccg tatgctgaag ctaatcctta acagcggata aaataaaggt tttaatattg 633781 cattatgtat aatgagtatg tatttttatg ctattcttgt aaaagtttgg cttattattt 633841 actttcatgg aacacttagt aaaaataact tagaaaggtc gtcttttctt tattctttag 633901 catttcaata ccgaactaaa tatccgtttt tatagtttag ttggttttgt ttaatttcta 633961 gaatcctgtt cggcgctttt gttaaaagta aaaaatgaaa attcaaacga aatgaaccta 634021 atcacgttag aatttaaatc ttggaatatg ttaaatataa aacaagaaga gcaagcaata 634081 ctatttctga ctaattctct atacacataa gagcaaaaca aaatgttcgg tagcaaacgt 634141 ctgaaaaatg ttaaggaagc atttaagtcc ctaaaaggcc aaaattcaga gacacccatt 634201 gagaactcaa aggcgtcttt taaatccaaa aattcaaaga catctactat ttccaaagat 634261 gcgaaatctt cctcttcttt gaagattcct ataagttcaa ataacaaaaa taaaattttt 634321 tcactagcag aaaccaacaa atatgggatg agcagtaaac cgatcgcagc cgctttcgat 634381 ttcacccaaa atttattggc aattgctaca gtcacagggg aagtccatat ttatggccag 634441 caacaagtgg aagtggttat aaaactggag gatagatctg ctataaaaga aatgagattt 634501 gtgaaaggta tctatttggt ggtcattaac gcaaaagata ctgtgtatgt tttatcgtta 634561 tattctcaaa aagtacttac aacagtgttt gttccgggga aaataacatc aattgacaca 634621 gatgcatcct tagactggat gctaatcggc cttcaaaatg gttcaatgat agtttacgac 634681 atagataggg atcaactttc ctccttcaaa ttagacaacc tacaaaaaag ctcatttttt 634741 ccggctgcaa gactatcacc tatagtatcc attcagtgga accctagaga tattggaact 634801 gttttaatat catatgagta tgtaactcta acatactcat tggttgagaa cgaaatcaaa 634861 caatccttca tatacgaatt accacctttt gctccaggag gcgacttctc agaaaaaacc 634921 aatgaaaaga gaactcccaa agttattcag tccttatatc accctaattc actgcacatt 634981 atcactattc atgaagacaa ttccttggtt ttctgggatg ctaattcagg ccatatgatc 635041 atggcaagga cagtgtttga gacagaaatc aatgttccac aacctgatta catacgcgat 635101 tctagtacta atgctgccaa aatttcgaaa gtgtattgga tgtgtgaaaa caatccagaa 635161 tatacttcac tactcatctc tcataagtca atcagcagag gagataatca aagtctcact 635221 atgatcgacc tcggttacac acctagatat tcaataacct cttatgaagg tatgaagaac 635281 tactatgcaa atccgaaaca aatgaagata tttcccttac caaccaatgt gccaatagtg 635341 aatatactac caattccaag acagtccccg tattttgcag gatgtcataa tccggggtta 635401 attttgttaa tcctaggtaa cggtgagata gaaacaatgc tatatccttc tggaatattt 635461 acagataaag cctctttatt ccctcaaaat ctttcctggc tgagaccatt agccacgact 635521 tcaatggccg cttctgtacc aaacaaatta tggcttggtg cgctttctgc agctcaaaac 635581 aaggattatt tgttgaaggg aggggttaga acaaaaaggc aaaaacttcc cgctgagtac 635641 ggtacagcat tcattaccgg ccattctaat ggctcagtta ggatatacga tgcttcccat 635701 ggggatatac aagataatgc tagctttgaa gtgaatctat caagaacgtt gaacaaggcc 635761 aaagaactag cagttgataa gatatctttt gccgcagaga ctctcgagtt ggcggtgtca 635821 attgaaacag gagacgttgt tttattcaaa tatgaagtaa accagtttta cagtgttgag 635881 aacagaccag aaagcggtga cctggagatg aatttcaggc ggttttcttt gaataatacg 635941 aatggtgttc tcgtcgatgt gagagacagg gcacctaccg gtgttaggca gggatttatg 636001 ccatcaactg ccgtgcatgc caacaaaggg aaaacatctg caatcaacaa cagtaatatt 636061 ggatttgttg gaatcgcata tgctgccgga agccttatgt tgatcgatag aagaggtcct 636121 gcaatcattt acatggaaaa cattagagaa atctcgggag ctcaaagcgc atgtgttacc 636181 tgcatcgaat tcgtaattat ggagtatgga gacgatggtt actctagtat attgatggtc 636241 tgtggtactg atatgggcga ggtaatcaca tacaaaattc ttcctgcatc aggtggaaag 636301 ttcgatgtgc aactaatgga tattactaat gttaccagta agggtccgat acacaaaatt 636361 gatgcatttt caaaggaaac aaaatctagc tgcttggcaa ctattccaaa aatgcagaat 636421 ttaagtaaag gcctttgcat tcctggtatt gtattaataa ctggattcga tgatatcaga 636481 ttaataacac tgggcaaatc taaaagtaca cataaaggtt tcaaataccc gcttgccgcg 636541 acaggtttat cttacatctc aaccgttgag aaaaataatg ataggaagaa cctaaccgta 636601 ataattacat tagaaatcaa tggccatcta agagttttta ctattccaga tttcaaagaa 636661 caaatgtctg aacatattcc atttccaatt gccgcaaaat acattacaga atcatctgtt 636721 ttaagaaatg gtgatatagc gattcgagtg agtgaatttc aggcgtcact attttctact 636781 gtcaaggaac aggatacgct agcgccagtt tctgacacac tgtacatcaa tggaatcagg 636841 attccctata ggccacaagt aaattcatta cagtgggcaa gaggcactgt atattgtact 636901 cccgctcaat taaatgaatt attgggtggc gtgaatagac ctgcatccaa atacaaagag 636961 agcatcattg ctgagggaag tttctcggag cgttcttcag acgataataa tgcgaaccat 637021 ccggaacacc agtataccaa gcccacccgt aagggcagga acagtagtta cggggtacta 637081 agaaatgttt ctcgagctgt agaaactaga tgggacgccg ttgaagatag attcaacgac 637141 tatgctaccg ccatgggaga aacaatgaac gaggctgttg agcagactgg aaaagatgta 637201 atgaaaggtg cccttggttt ttaaatacat acactaattc atacagggta atgagcaact 637261 tccttctata cttatttttt tttagttcta tatgctttat aaattaattt gaatcgattt 637321 atttttcatt atacatgtct agttttacga aggtttgtaa atacatgagc tatcaagttt 637381 ataatccttt aattaaacga gtgacctcat ttagaccatc ttcatgaatt tgtgataact 637441 tttcttgaac aataggaaca atgtcagccg cactaaccaa ttcaccatca tcatcggcaa 637501 attcttggcc caatcttttg acacgtaatt taccttctaa gtactcctcc ttaccgagga 637561 ttacggcaat gtgacaaccc gctttttcag cagcatcgaa ttgcttccta ggattagcct 637621 tggccttata gacatattca gcttcaatgc cagcatccca taattgctta gtaaccttca 637681 ttctttcggg taaataacca gtccagtcct taccaccacc aaaagccata acgaacacct 637741 gtgtagccgt tggctttata gttgtagagg aattaattct ttgtttgatc aaagaaaata 637801 ttctttcaac accaaatgaa ataccaacac atggaatttg agtagatttt ttgccggaag 637861 cttcagagaa catgttgacc aaattatcat atcgaccacc ggctgcaata gagccgacac 637921 caacgaattc tgacgcgtct tctgcagatt tggccttctt cttcaattct gaagcattct 637981 ctggtggagc agatgcagaa gtaacaactt catagatcaa acctgtatag taatccaaac 638041 ctcttgcaag agaaagatca aaagagatga atgagtcaat gtcaaatgct tcggtatact 638101 tcatcaaagt agcaatatca tccaaacctt gtttagcctt ttcgtttgaa gtaatgttgg 638161 catctgcgga tagaacagcg tgaatttcct tcaaagaacc atttaattta acatactcac 638221 cgattttatc agcagtttct tcggattgac ctttttcttc ggtcatttcc ttcttgactg 638281 cttcccatgg agatttgtcc aacttatcga cagcagaaga gattttcctc acatcctcat 638341 ctttaacacc agcgatttgg aagatcccat caagaatctt cctgtgattc aatttgattt 638401 tgaaatcttt gattcccaaa ctggtcaaac cttccactaa aatggacaaa cattcggaat 638461 caggaaccat agattcgaat gtgcctgcaa cgtcaaaatc acactggtaa aattctctca 638521 tacgaccctt agtcatggct ggttggtctc ttctgtagac ttttgcaatg tgatacctct 638581 tgatactctg aatattgttc atggcaacgt acctggcaaa aggaacggtc aaatcgtaac 638641 gtaaagaaca taattcacca ccctggtcct ccaagttgta gatcagtttg gagtcctcac 638701 catacttgcc tgctaaaatt tctcttaact cgaaaacagg tgtgtcgata gtgacaccac 638761 catgcttctt gaataggcca gataaagtgc taaaaatggc ttctctgata accatatcac 638821 tatcagccca atccttcgta cccttaggtg ttttcaaaga cacttgtagt ttacctttct 638881 ttggagcctt tgaagctttt agagcattag cagcattagc agtaggagca gaagtagcag 638941 cagcggtagc ggatgacatc ctgattatcg aagacgactt tatagatgtg actactttat 639001 ttagtgatct actaagcatt aagcaagaga cgagcagaaa ggaactattc taaagtaaca 639061 cattgggccg taagactcat ttaaaagccc ggtcgatcaa ggccataagt catcttcgag 639121 ctggttagaa ttgaagaaaa aaaaaaactt gataaaaaat ttcaaacaaa aaaattatcg 639181 ccttacacgg aaacgaatag atttacttat tacacaagag agaacagtga ttataaggaa 639241 agaaagagat atatacaata tttccatcaa agacgtacgc atcacggcgt tcatataagt 639301 atatcatcgg caagtcttca cacctttcaa tacttagact tgttcacctt gagtgatcct 639361 gaaaaaaaaa aatgatggcc gcgtttcgaa gaaaataaag aaaaaataaa gcaaacctca 639421 aacaagaaaa caaagcggaa aatggtaaac aagagagata gaacagagta gtaggctatt 639481 agcaaaagcg cgagaattac tacattataa aggatctgtc aagaatgaca ttgaatagga 639541 agtgcgtagt gatacataac ggatcgcaca gaacggtggc tggatttagt aacgttgaat 639601 tgccacaatg cattataccc tctagctata ttaaaagaac agatgagggg ggggaagctg 639661 agtttatatt cggaacctac aatatgatag acgctgcggc agaaaaacgc aatggtgacg 639721 aggtgtatac attggtagat agccaagggt taccgtacaa ttgggacgca ttggagatgc 639781 agtggagata tctgtacgac acccaattga aagtttcacc cgaggaactg ccactggtga 639841 ttacgatgcc tgccaccaat ggtaaaccgg acatggccat attagagcgc tactatgagc 639901 tggcgttcga caaattaaat gtaccagtat tccagattgt aatcgagcca ttggcaattg 639961 ccctatccat gggcaagagt tctgcattcg tgattgatat cggcgcgtca ggctgtaacg 640021 ttactcccat cattgacggt attgtggtga agaatgctgt agtgagatct aaatttggcg 640081 gtgatttctt ggattttcaa gtacacgaaa ggttggctcc actgattaaa gaagagaacg 640141 acatggaaaa catggccgac gagcaaaaaa ggtccaccga cgtttggtac gaagcaagca 640201 cgtggattca gcaattcaag tctactatgt tgcaagtaag cgaaaaggac ttgtttgagt 640261 tggaaaggta ttacaaagag caagcagata tatacgctaa gcaacaggag cagttaaaac 640321 aaatggatca gcaacttcag tacacggcgt taacgggaag ccccaacaat ccgttggttc 640381 aaaagaaaaa ttttctattc aagccattaa acaagacttt aaccttggac cttaaggagt 640441 gctaccaatt cgcagagtat ctcttcaaac ctcaactgat atcagacaaa ttctcaccag 640501 aggacggact gggaccgcta atggcaaaat cagtcaagaa ggccggcgct agtataaatt 640561 caatgaaggc caatacctcc accaacccaa acggattggg tacaagccat ataaacacca 640621 atgttggcga taataacagt actgccagca gcagcaacat atcaccagaa caagtatact 640681 cgctactgtt gacgaacgtc atcatcacag gatctacctc tctgatcgaa ggtatggagc 640741 aacgcataat aaaggagctg tcaatcaggt tcccgcaata caaattgaca acttttgcca 640801 accaagtcat gatggaccgt aaaatccagg gatggctggg cgcccttaca atggccaatc 640861 tgccatcatg gagcttggga aaatggtact ctaaggaaga ttacgaaacg ctgaaaagag 640921 acagaaagca gtcgcaggct acgaacgcaa caaactagtg gtaaggcgca aatatccaaa 640981 agggattgta ggcggctaga aggagatgag atctcgaccc atttttctca gcgccggtag 641041 tagctatcag taaggagtaa gcgggtttcc ttcaagattc agtccacccc ctactttgag 641101 tgagggacat ataaacaaac gcgataactc gatgaaccca ttctaatata aaaaaactgt 641161 ataaatagtt atatagagat gaactctaag ctagtgaggc ccactgtaaa cagccatttt 641221 tcaatatgcg ctacccggcg gcggaatatc gtcccagcta catgatagcc gcttttttgt 641281 ctctctttgt cccacctgtt caaagacatt tggtaatcag tttgtcagga caatagtaaa 641341 caaaagtgcg caagtacaca tgcgctgcac gtgcggccgg aacaatggcg cttttggctc 641401 gtccggatga tgcgaaaggg aaaataaaat ctcgcaatcg gaaaaacact cgcgagaacc 641461 aaaacaagga tcccctaaac ccagtacccg catacggttc tcccggggaa aagggggcgg 641521 aggccggacg atgagtgtta cccggatagg actacggatc gcttcgcacg tttgtttaca 641581 attgatgact gcgctcccct aatagataag ataagctcgc gaaggcagaa aaaaaaaagt 641641 cttctacagc agttggtccg cacagacgat gccagacggt gttttatcga aaattttttt 641701 cgcatcatag tgccatttgt ggtcattatt attccccaaa tatgcgaaaa tagtacacta 641761 tttttggcag gagagtaggc tgatatgccg cattgatgtc ctgtgtagcg aaacacaaac 641821 aaaaaaagaa aaagtaggat gaaaaaaaga aaagtaatat gaaaaaagag tgaaaaatta 641881 attcatttgt tagtgtaagc ggtcaggtgt aagtagtagg cttgataatg aattaaagat 641941 gactccgacg catattgttt gccatgtttt tattttagtt tgtagatttc tttttttgta 642001 atatataagg gagtgattct atatatcgaa ttctcaggct tggttggttc gtaggttgtt 642061 ctgtctttgt tttcgttagg taagaacatc acacaaagat aactatagaa tcacatacat 642121 atttgtgaga aattaacttc atttcattta tagaagaagt tcaaccgaaa caaaaattaa 642181 acataatata atataatata atcaaaaatg gctgaagcaa gcatcgaaaa gactcaaatt 642241 ttacaaaaat atctagaact ggaccaaaga ggtagaataa ttgccgaata cgtttggatc 642301 gatggtactg gtaacttacg ttccaaaggt agaactttga agaagagaat cacatccatt 642361 gaccaattgc cagaatggaa cttcgacggt tcttctacca accaagcgcc aggccacgac 642421 tctgacatct atttgaaacc cgttgcttac tacccagatc ccttcaggag aggtgacaac 642481 attgttgtct tggccgcatg ttacaacaat gacggtactc caaacaagtt caaccacaga 642541 cacgaagctg ccaagctatt tgctgctcat aaggatgaag aaatctggtt tggtctagaa 642601 caagaataca ctctatttga catgtatgac gatgtttacg gatggccaaa gggtgggtac 642661 ccagctccac aaggtcctta ctactgtggt gttggtgccg gtaaggttta tgccagagac 642721 atgatcgaag ctcactacag agcttgtttg tatgccggat tagaaatttc tggtattaac 642781 gctgaagtca tgccatctca atgggaattc caagtcggtc catgtaccgg tattgacatg 642841 ggtgaccaat tatggatggc cagatacttt ttgcacagag tggcagaaga gtttggtatc 642901 aagatctcat tccatccaaa gccattgaag ggtgactgga acggtgccgg ttgtcacact 642961 aacgtttcca ccaaggaaat gagacaacca ggtggtatga aatacatcga acaagccatc 643021 gagaagttat ccaagagaca cgctgaacac attaagttgt acggtagcga taacgacatg 643081 agattaactg gtagacatga aaccgcttcc atgactgcct tttcttctgg tgtcgccaac 643141 agaggtagct caattagaat cccaagatcc gtcgccaagg aaggttacgg ttactttgaa 643201 gaccgtagac cagcttccaa catcgaccca tacttggtta caggtatcat gtgtgaaact 643261 gtttgcggtg ctattgacaa tgctgacatg acgaaggaat ttgaaagaga atcttcataa 643321 gcataataca atggtgcaaa atttttttta ggcaggaact aatctactaa taaactaaca 643381 ataatgcaca ggaaatatta atgatttatt tatttatttt actactatat tacattactt 643441 ttttacataa aaaatttccc atctcacgat caaaaacagg catgagaaaa aatcaaaatt 643501 tataaaatta atttctaata aattaactgt aatgacataa aataagaggc tgcgacagtc 643561 gaattttttc tttttttttt tctgcaaagc gacgctgtgt tgtatattgc tctaaaataa 643621 ttttctattg ttttcctcat gccattaccc tacctacccg tgcataatta cacgaggggg 643681 agagcttttt cttcccaaac cagaccagga aaaaaaaaaa ggtttgataa tgaaaaaaaa 643741 aaaaagtatt gtatatgact gttttcctga taaaagaatg cctgcaataa ttcaaagaca 643801 agagatataa aagtgcactg gcgatttcag gaacaatggg cgcaaccaaa attttaatgg 643861 acagtactca tttcaatgag atccgtagta taatccgttc gaggtcagtg gcatgggacg 643921 ccttagccag atctgaggaa ttgagcgaaa ttgatgcgtc tactgcaaaa gcgttagaat 643981 ccattctggt gaagaagaac attggtgacg gtttatcatc ttcgaacaat gcacattccg 644041 ggttcaaagt gaatggcaag acgttgatac cattaattca cttactttcc acctcagaca 644101 acgaagactg caaaaaatct gtgcagaacc taatagctga attgttatcg tctgacaagt 644161 atggagacga taccgtgaag tttttccaag aagaccccaa gcaattggaa caattatttg 644221 atgtgtcact caagggagac ttccagactg tgctaatctc tgggttcaac gtggtctcac 644281 tcttagtgca aaatgggttg cacaatgtga aactagtgga aaagctgttg aaaaacaaca 644341 acttgatcaa tatcttgcaa aacattgagc agatggacac ttgttacgtg tgcatcagac 644401 tattgcaaga actggccgtg ataccagagt atcgtgacgt gatatggttg catgagaaga 644461 agttcatgcc caccttattc aagatcctgc aacgtgccac ggactctcaa ttggccacgc 644521 ggatagttgc aacaaactcc aaccacctgg gtattcaatt gcagtaccac tctttactat 644581 tgatatggtt gctgaccttt aacccagttt ttgcaaacga gctagtccag aaatacttga 644641 gtgatttctt ggacctcttg aaattggtta agataaccat aaaggagaaa gtgtccagat 644701 tgtgcatatc catcatcctg caatgttgct ccacgcgcgt caagcagcac aagaaggtga 644761 ttaagcaact tttgttgctc ggcaacgcgt tgcccaccgt acagagcttg agcgaaagaa 644821 agtattccga cgaagaattg cgtcaagaca tcagcaacct caaggaaatc ctagaaaacg 644881 agtaccaaga attgacctcc ttcgatgaat acgtcgccga attggactcc aagttgctgt 644941 gctggtctcc accacatgtc gacaacggtt tctggtccga taacattgac gagttcaaga 645001 aggacaacta caagatcttt agacaattga tcgaactctt gcaagcaaag gtccgtaacg 645061 gcgacgtcaa cgcgaaacaa gaaaagatca ttatccaagt cgccttgaac gacatcactc 645121 acgtggtcga gcttctacca gagagcatcg acgttctcga caagactggc ggcaaagccg 645181 acatcatgga gttgctgaac cattcagatt ctagggtgaa atacgaggcc ctcaaggcca 645241 cgcaggcaat cattggatat accttcaaat aaagatatag aagaccgtaa agtagtagtg 645301 ggtttgaagc ctaaataagt agttttgtac gtactattat tttaagagaa gaacatccat 645361 agaaaagaaa agaagaaaaa gaaacgaacc agaagagggt agcagaatca gtcattcacg 645421 cacccggcct gcgctgcgtg caccgactgc gtgcgtgcgt gattggtaat gcagtgaatc 645481 atgctttttc atgacgcctc ctccccgccc ctgagccttc ggtggccgcc gaagtcgggt 645541 attaatgggc gcccctttcc tggtgtccgg gaaccgcctg ccgaaaacca ccctccgcag 645601 gtccgcggaa ggtgggtgtg gctgtccccg cgcaaatccg agatcgattc cgcggcgggt 645661 cggtcattct tttcatttgc gcgctaatat gcgctgtgac tggcggttag tcatctgcgt 645721 gatcaatcgt tgtcatgacg ctctataacg taagagaact ttagaggggg ctcaattagc 645781 atgaagaaca gacacatata taaggtctct agatttctcc aatagctcaa ctctcacaat 645841 tgtttcctct agtccttgta aaatataaaa aatcatcatc aaacaagcaa ctacaaaaca 645901 gctttactga caactcacac aaataacaca aaaaacaaaa atttcaacaa tggtcgcctt 645961 tttagaacta acttctgacg tttctcaacc ttttgtcatc ccatctcttt cgccagtctc 646021 tcagccaagc tcaagaaaga actctgacgc aaacgtcgat gacctgaatc tggctattgc 646081 caatgccgct cttttggatg cctctgcttc aagccgctca cactccagaa aaaactcttt 646141 gtctctgttg taagtgttgt acacgagaat tagcacacta ttagcataaa agacacttgg 646201 catctttact tacttgggca agtaagtcac gtactttttt ttttttttcc ggagcattca 646261 ttgtcattct atctgcactt tcccgcactt acattcaata acctcggatc gggtctcttc 646321 tacgacagaa actttttgat atatacatat ttatgtaata taaatactga gaaagtaaaa 646381 aaatttaaaa tataaaataa taaaaaattt actattacta taattgatta atgtaatctt 646441 tctttgttca accgtgctgt ttagcctcct tctcgagaga cacgcgttta ccgtcgctgt 646501 cactacatcc acaatcgtag tcctccagga tggtagcaca gtcatatatg tctttcttta 646561 ggtattcgtt caccttgttg tgaatgtggc atccccacat tgcggcagcc gtcctgctag 646621 atgtctgtac gggatacttc tcaatcaact ttacaaagtg atatgaacat tccccgcatg 646681 gatagagttc tgcatacaac ccaataaacg tgtgcagttt ctctctttct tcaggagtag 646741 gctcgtccgg aaaacgggcc agcagggtat ggaagtactt ccacgacgcc ctgcccactt 646801 ccttcttcac cttgtcatcg cccatcaatg gcataatggt ttgcttctcg atctctttca 646861 accgagcgtc gttcttctca gcagccgccc cttgcacttc atctatacca gacttcgcct 646921 tgattaggcc cggcgtagcg atggatagtt cattagacga gaaaaacatc cacaggccta 646981 tgattcctaa tgctgcaact attctgatgg catggcttct tttgactatc tgtttcatcc 647041 cttcgttcct tgcacaatct gtccagactt tcctctttac aaatcaccag ccttcccgtc 647101 ttcttgtctt catcacccac gtttattgtt taatgataaa gccttttgtc ctttattttt 647161 ggttcctttt cccgcttcgt ttacccggtg gttaaccttt ctcttccatc ttgtaatata 647221 taataacaaa atgcatcacc atacttacgc accccatata catgacctaa gggcagcttt 647281 agacacaaca gctccccaga aaaaatgtcc aaaagaaaca ctccaccgct cagatcatca 647341 gggataaaca ctattcaaat aaatgctgct agagaaatgc acgctcaaac ggtgcgcgct 647401 cgaagaatgc ccatgccaac tagcggcatc actacaccct ctgtgcaacc aactgcagcc 647461 ccagcaacac cacctcgaca tatttgcaat aacccaaaca atccgcagtg tctccactgt 647521 gggtctgtta tcattccatc tccaagggcc acgttaccct tggaggacaa cccctccatc 647581 tccatcaacg actggaccat ctcctccaga aagaagccca ttttgaactc gcaggaatta 647641 gacatctggg aaaacgaaaa actcaaaggt ttgactttgc cagagatgat ttttggtaac 647701 aactacatca ggatcgaaaa ttcaaaacag cattggtcca tagagttcaa tgccctggat 647761 gctttaaagg aggttcaact ccaggattca ggtattcgtg ttgcgtactc aaacgactgg 647821 ataaattcta aaaaaagaca aaattcaact aatggtgcgc aacggttcac taacgatgtg 647881 aacgacgatt ccttaaatat catacacaag tacgactgga cctacactac gcggtataag 647941 ggcacagaga gctcacctga gtcgaaattc cgactggata acgatcaaaa gctgcccctt 648001 gacaaactgg ccgtacacga taaaatccta ttctatgacg acatgattct tttcgaagac 648061 gaattggcag acaatggcat atcaatcctt aacgtcaaaa taagagttat gaacgaaagg 648121 ttactgctgc tgagccggtt ctttttaagg gtggacgatg ttctggtgag ggtctacgac 648181 accaggattt acgtggagtt tgacgaaaac gtagtgatca gagaatccaa ggaatttgaa 648241 ggtaaatatc aggatgtact tgctaagcac cggctatccc aatctcacga cccaaaagct 648301 gccttgagag atagtaattg ggtagcacag aacacgccga tgatcaaaag acaatgtgaa 648361 ataattcagt tctaacaatc aaatatacaa aacaatacgt acaaatacat acacgtcaca 648421 tatacataag ctccggatac atcatacaag aaatgatctt aaaatcatgc tcttacccgt 648481 tctgtaaata gtgaaaaatt ttcatcgcga agtatgaacg aaaaaaaaaa aagaaaatag 648541 atgaactttt agcatttaat tagtggcaaa cgcctacccc tccttcccac tttgctgact 648601 tacaaagaca ccactacatt aaagagtatc tcgtgtgttc ttcttttttt tccaaaaaaa 648661 aaaactccta ttatttgcat aaacacacgt tcactggtac aagatgtcta ttaatatttg 648721 tagagataat catgatccat tttaccgtta caaaatgcct cccatccaag ccaaggtgga 648781 aggtagaggt aacggtatca agactgccgt tttgaacgtc gctgacatct ctcacgcgct 648841 aaatagacct gctccatata ttgtcaagta ttttggtttc gaattaggtg ctcaaacttc 648901 catctctgtt gacaaagatc gttatttagt taatggtgtt cacgaacctg ccaaattgca 648961 agacgtattg gatggcttta ttaacaagtt tgttctctgt ggaagctgta aaaatccaga 649021 aacggagatc atcattacca aagataatga tttggttcga gactgtaaag cctgtggtaa 649081 gagaactcca atggacttga gacataaact atcatccttc attttgaaaa acccacctga 649141 ctccgtttct ggttccaaga agaagaagaa agcagctacc gcttcggcca atgttcgtgg 649201 tggtgggttg tccattagtg atattgctca aggtaagtct cagaatgcac cttcagatgg 649261 caccggctca tccactccac aacatcatga cgaagacgaa gatgaattat ctcgtcaaat 649321 caaggcggct gcctctacct tagaagatat cgaggtcaaa gatgacgaat gggcggttga 649381 tatgtctgaa gaagccatta gagctcgtgc caaggaacta gaagtgaact ctgagctcac 649441 tcaactggat gaatatggtg aatggatttt ggagcaggct ggtgaagata aggagaactt 649501 accatcagat gtggagcttt ataagaaggc tgcagaacta gacgtcttga atgatccaaa 649561 aattggttgt gtcttggcgc aatgtctatt cgatgaggat atcgtaaacg aaatcgctga 649621 acataatgca tttttcacta aaattttagt cactccagaa tacgaaaaga actttatggg 649681 tggtattgaa agatttttag gtttagaaca taaggatcta atcccactat taccaaaaat 649741 tttggtacaa ctatacaata atgatatcat ctcggaagaa gaaatcatga gatttggtac 649801 caaatcatcc aagaaatttg tacctaagga ggtatccaaa aaggttcgta gggctgctaa 649861 gccattcatt acgtggttag aaaccgctga aagtgacgat gatgaagaag acgacgaata 649921 gcttaggagg gggcaaaaga cttatgtgta aattattata tgacatggcg taagataagg 649981 attatgttct gttgtttttg agctcgttga tgtatagata tgtaaatatt tataaatata 650041 atatttcttc caagtgcgac atacttggta ctggcaaaaa acaaagatga gacttttaaa 650101 gccactgatt gattgattaa ttattaagta aaaaaaaaaa aataaaatgt cggtgtaatt 650161 tggctccacg atcgcatgcg tatacataac atgagattac cgaagatttt tctgaaaggt 650221 aatgcattat attataatca ttaatagaag tagagcctaa agcctgttga aaacttgtac 650281 aatagaggaa aaaaaaaggg tcattaatcg tcatgtttac ctaagagcgt ctaaactttt 650341 tggtattctt ctggggtaaa cgtaaaaaca ttgcaccaag ggcaaaattg aaaaaaaaaa 650401 aagtttaata gaacagaatg attaaaatca ttagctaata tccgtatgac ctgtagcggt 650461 acaaacttgt atcattatta ttattattat tactattatt actattatta ttattattat 650521 tattattatt attattatta ttattgttat tgttattatt attgttatca ttatcattat 650581 tgttgtagtt attggtatta ttattgttat tatgactcac tgagcggctt agaggattca 650641 tttgactcga ataaccagaa ttattataat tgttattatt attacttaca tttggtaagt 650701 taactatagg tagggataaa tttgttccat tagcaattct aaatgaatca aattgtgaat 650761 tcaattcatc taatccgtta gaattaccgt tctgattttg attttgattt ccggagtaca 650821 ccacttgttg attgttgaag taggaattta tttcactcat cggggctggg ttaaagttca 650881 atgctggcgt tggacctgca ttgttcattt gtataacgct attatgcctt gaatttgaac 650941 ttctcacact ggaaacagaa acgcctctgg cgcgaccagg agaatgaaac ccctgaggat 651001 gctgtttacg atgattcttg gaggattgtt tgggtgatat tcctgctgat gatagcccaa 651061 cttcctccag taactggcga ctttgtaaat tgatattgga atttaaaatc agttgacgaa 651121 tctttgttat agcttcatct ctaacgctat tgtcaagaat tctcgaggtt aaaaccttat 651181 aaataaatgt tggaccataa ttaccctcat ctagtatctg gaacaagata gaatcactag 651241 aaattggacc atcaaatatt gcatggataa ttttattctt cgacagtgcc tcttcttcac 651301 cacctcttaa attgagaatc tttaagacag taagagagcc taatttatga caacatagtt 651361 taaccagatt tttatttacc agtttatcac ataaaatcaa gttcttgtta ggtaaagtgc 651421 aagtatccaa tagccaagtg atcagtaaag tgccattcgt atccgtagct agataaggag 651481 aaagcacaat tatcagtgaa gtgatagtca gcaattggca ttgggtaata atggaatctg 651541 cttctagaca agcccttaca gcacgagatc catacctgtt ttgaactatt gtccaaaaat 651601 gagataaaac gctttcaaaa atgaaactat tccagggaaa accaaacttt aaaatacctt 651661 gaataacata atttccaaac tggtcgttga agagtggagt acagtaatcg cttacacctg 651721 aagttacaag atttatctgc cttggcgtgt ttgccatttt gatgatcttc tgacaaaccc 651781 aagtaccgtt tttgtgaaca cccatagatg tgagatattt attacacttc ctcaacataa 651841 tatccctgat gatatttgac gagttttcaa acaatttttg aataacggta ttacccaaat 651901 agtctgaact taattctggt aattggtcca gcatgacgat tgccaattgc tccatttcaa 651961 tagtagataa tgagttcgag tcaaactgct ttctcagttc ccgcaatttt ggtgcatcga 652021 acgtatcctt tctctttgga actttggagt tgtgctcagg caggggacca aaataatttg 652081 tatcagacac tcctttattt ttcaaggcat tctgcaagag atgattcaac tctagatgat 652141 catattctaa cttaaaagaa cttatagtgt gtaatatatc ctttttacta tccgataatg 652201 atggtggagg caacgggaaa gggtaaggtt cattttcgtt tgaagataat tgcagatggc 652261 tcaaattctg agtgggatta caatatgtaa gatttggttg attaaatgaa gttggttgtt 652321 gttgtagctc cggctgttgt agcgattgtt gcagctgata attgagcacc ccgtgattca 652381 actgttcttg caacagcggt tgcttgggag tgttgttgaa gccattaacg ttaagaggtt 652441 gttcatacat gggtaagact cgcgcaaaag ataccgtact tggtgcccct actttagaca 652501 gttccttacc ttgtagagct tccaaagcac atattgcact ttcaactgtg gaaaactcta 652561 ctaatgccat attcaggcct cttagtgtcc tcgcagaaag cactttacca tactgtgaac 652621 ataaagtcgc taaggaagta ctcgtcaaat ttacagcgtt ctgttgatgt tgttgagtag 652681 gctgtaatgg aaacacgttt gaaatagata ttgtgttagt gggcaaaagc gccgatattt 652741 gattgactag tggtactttt tggtttgctg taatccaatt tatcgaggct ggatcgacgt 652801 catcaaggat aacaggggat attgaagtac tttttggaac tctaggaggc acttgaacct 652861 ggtaattctg tgcaggctgt tgatagtagg gcgcgtcagt ataaaccctg tttgtggtag 652921 attgagattg agagcgctgc ctgttaacta tcggagtatt aaggtggtca gtgttactat 652981 ttcctgcact cgaccatatg tttggattcc catttttctc cagaaaactg tttagttgag 653041 ctgtttgagg cagcgtataa ttatcagtgg acttgaatct agtcaatggc tcaaaataag 653101 aagtggcgag aggataatca aacaaaggac tggaagaagt attactttct gcattagcac 653161 tccaaatatt tgcactcgtg gcattgccca catcagtagt caaagaagaa cttgcagtga 653221 tctgagaaga tactgtgtta tttcttgttc ttgttctggt cgtagtagac tgtaatgaca 653281 gcggagtagc caccgtaaaa gaatcgctag acactctggg agcgtatgtc gtggaattta 653341 aactgtctgg agtactgctc gtaggaggca caacaactac aggggtactc ttctttgaat 653401 ggtgtagctt agcgctaatc gaagggagta gattggttag agtatctgaa aacctgcccg 653461 cacgagtacg ataggagcca attttctgtg gggaagtgga gctagaacga cctctcttgt 653521 cagagactct cacagaacga gcatttgtat tcatgcgtgt atcatttcta atatcctctt 653581 cataaattgg aattgtaatt ccaggatcta taacctcagg aatgttggat aggttaccgt 653641 tatacagtct tttgttgtcc atcagaattc agaaaacagt agcaagggac agcgatagta 653701 gatatatctc tctaacaatg aatatacact taagctagta acaaataatt gaatggttag 653761 tatagaggaa agtaagttat gccgttgctc tgtgccattc agcagtatat gcaccatcgc 653821 ttgctctttc gaggggtggt ttcatactat ttcacaattt ttttacttag ttcttttttg 653881 gaacaacagc cgggttacca aaagatctca aacgaaacta agactgttca aattttcaaa 653941 gaatccgtac atttagaaat tttttttttt tccgcaagaa atatccttgc tttttttcac 654001 ttttgttaac tttttctaac gcaacgcacg aggcggctca ctcagtgtta tgtgagatat 654061 tgggctatat gggatgttag agttaggtat catatatagt atttggcacg ccttttttta 654121 gttcagacag tagtagcaaa caacaggaag acaactgaga caaaaatgta tgatatatta 654181 cgcacacgat ttaccgtttg cttggaggag tagtgtttcg tgatgaaata gactgatata 654241 gacagaattc cacagacttt tacgatataa agggaaaaac atgaagttga acaccatatc 654301 tcaaatgaat aggatcactg taattcgata gggtacaatt atgtgaaatg tctgctttat 654361 gggaactttc attcatatac ctgaaggtgg caaactagtc ttacgaaact gttcagtgca 654421 gagatagaat tttgtggaga tgcatatagg gaaacaaagt ggaatttatg cttgtataat 654481 caccaattcg aaacactaaa cctcgaccta tttagaattt ccttcaagat ttactaacat 654541 attttgatat tttttctttt ttgaatacag ggctaaaaga actaagaagg ttggtatcac 654601 tggtaagtac ggtgtccgtt atggttcctc tttgagaaga caagtcaaga agttggaaat 654661 ccaacaacac gctagatacg attgttcttt ctgtggtaag aagaccgtca agagaggtgc 654721 tgctggtatt tggacttgtt cctgttgtaa gaagaccgtc gctggtggtg cttacactgt 654781 ctccactgct gctgccgcca ccgttagatc taccatcaga agattgagag aaatggttga 654841 agcttgattt tattttaatt atatgtataa aaatcataaa acaactatat aattaattat 654901 aactcaaaaa cttttccagt aaatgtctgt tttttgggca ggaacaatgg ccaatagctc 654961 acgtactgtt cgtgggggcc ttaagcctgg tatctaggct ctgatttcca gaagaaagtg 655021 acatcgatga atgcactcaa gagattttat gtgttgtgaa tatgtatata tttatttaga 655081 aaaaaaaaaa aaaaaaaaaa ccaaaatcat ataccttagg catcccgttt ccctcttcat 655141 catttttgtc cctttatatc aattttttta gacttcatat aattttgtat caactgtacc 655201 ctacatccct tggtattcaa aatcttgata ttactacttt tgccattact gtcagtgatt 655261 tgtttgttta atatgaactc cgtcaagttt tgctcattca agaaatttgt tgtctcttct 655321 atactgttga aattaaactc acttttaaca aaatctaaat tgacctggtt ataactctta 655381 caaattatgg tcaaaaatat caacttttct agatttaaga atgaattaat tagacatttt 655441 tcaaatttgt gcagttttag gtagtttttc atgaagtagt gataattgcc gactagtttc 655501 atatcgctca actcaaatat cattttgaca tgttcgtcct ccaagatttc cgaagagcca 655561 tcgtctatta acttaagttt taaatgagaa atcgacggat agtcttcggt taacatcgaa 655621 tacaaaacag aatagcatat aaattcggaa taagattttt ttggtattgt agggttttcg 655681 aataacgcca taatcctatt ttgacattga ttaaattccc caagatctcc gttctccaag 655741 gcaatacgtg catgcgtttg gtacacttta atagtgaaag agttctcgat catttgcact 655801 cttaggtctt gtctcattga tttaaactgg tcgcaaaggt aagtataagt ggctgtttta 655861 gattggtatt tgtccattaa caagcaatac attttttgta gaatatttgg gggtctgatc 655921 aagtcaggat taggctctga agttagtctc agataagatt tctctagagt ttggcaacgc 655981 cctaccacat gaatcttttt gtcatattga tgagatttgc tactaatggc atttaggttg 656041 gcaaagtctt cattcaaatt atcgttacta ttcgtcgtcg ctgatggtcc ctgactgaat 656101 ctttctgccc ttctctttct tctctctaat tcatcactgc cacccatttc aactttccat 656161 cccgatgccg aacctacagc accatgccct actatattac tgttgctcat tacattgccg 656221 gataccccgt tagaaagggc tgatgccttc ttagatactc ttggtaattt ctttttaatg 656281 tttttgttca tacgtttttg taatcccgga agcggtgtta ccatcaaagg gttagaaacc 656341 tggttgacgt tgttccaaga taaacgtggt tctggcaaag gcagagaagg ttgttgattg 656401 gcaatgaaat tattattatt gtatgtcaga gaagggaaag atccggcgta atctaggggc 656461 ctattcaggc tttggccgaa tggtcctcct tgagatgaag cttccctgtc ctccgtggta 656521 ttgttagtaa agtgaccgta aggattctgc ataatgttat tggaaactca actactcgct 656581 gccgaacggt tcctactcct tgtattctat ggtttcttta cgagacagcc aaatctctat 656641 tttttgtcat gttcagtcct tttttactca aaaattccaa accgtgaagg atgatgcatg 656701 ttgacaataa atgatagccg tcatcacata cagtgtgcaa tatctagata cttctaacca 656761 tttcttcctg tcgtggggag ttcataccat tttgacagat gacaaacagt agtgaaaaac 656821 aatgggaaag aatccagcaa ttagaaaagg agcacgtgga ggtatataga gagttgttga 656881 tcacgttgga caggttgtac ttgattagaa aacacaatca tgcggtaata ttaagccata 656941 ctcaacagcg cctcttggaa attagacacc aacttcaaat taatcttgaa aagactgctc 657001 ttcttattag actgttggag aaaccggaca ataccaatgt attattcacc aagctacaaa 657061 acctcttaga agaaagcaat tctctggact atgagctctt gcaatcgtta ggtgctcaat 657121 cttcattgca caaacagttg attgaatcaa gagcagaacg cgacgaattg atgtcaaaac 657181 tgattgagtt atcgtcgaag tttcccaaac caactatacc gccagacgac agtgatactg 657241 ctggaaaaca ggttgaggta gaaaaggaaa atgaaacgat acaagaattg atgattgctt 657301 tacagataca ctccggatat acaaacatat cctacacaat ttgattttta tcttctaatg 657361 ctatttatat attcaaataa ttttaatact gacaacgcta ataataatag ttacttaatt 657421 aaggtttgaa tcttcgagaa aaaaaaaagg taggaaaatt aaggaactac tcacaaattc 657481 agagagagag aagggataaa aaaatatctg ccaatggagg taacttcaat gtttctcaat 657541 agaatgatga agaccaggac tggtctttat cgcttatatt caacccttaa agttccacat 657601 gtagaaatca atggcataaa atacaagacc gacccacaga ctaccaatgt tacagattca 657661 ataataaagc ttaccgacag atcattacat ttgaaagaat cacatccagt aggcattctt 657721 cgcgatctaa ttgaaaagaa attaaactca gtcgacaaca catttaagat ctttaataat 657781 ttcaagcccg tggtaaccac aatggaaaac ttcgattctt tagggtttcc taaggatcat 657841 cctggaagat caaaatctga cacatattat ataaatgaga cgcacctact gagaacacat 657901 acttcagccc acgaattaga gtgctttcaa aaaataagaa acgattcaga taatattaaa 657961 agtggatttt taatatctgc agatgtgtac agaagagatg aaattgacaa aactcactat 658021 ccggtattcc accaaatgga aggagccaca atttggaaac gaacgaaggc tgatgtgggc 658081 gtaaaggagc caatgtatat cgagaaaatc cgtgaagata tcagacaggt agagaacctt 658141 ttaaataaag aaaatgtaaa gattacggtt gacgatgata ctataccttt gaaagaaaat 658201 aatcctaaac aagagtatat gtccgatctg gaggttgatt tgtgctctca acatttgaag 658261 aggtccattg aactgatagt ttctgaagtt tttaacaaaa aaatatctag catgatcaag 658321 aacaaagcga ataatacacc caaagagcta aaagtccgtt ggattaacgc ttacttcccc 658381 tggaccgcgc cctcatggga aatagaggtt tggtggcagg gcgaatggct cgaactctgc 658441 ggatgcggat tgattcgtca agatgtgcta ctaagagccg gatataaacc ttctgaaaca 658501 attgggtggg cttttggctt gggtttggac cgcattgcta tgcttctttt tgaaattcca 658561 gatattagac tgctttggag tcgtgatgaa agattttcaa gacaattctc caagggatta 658621 attacttcct tcaaacctta ttcaaaacac ccgggatcat ttagggatgt tgcgttttgg 658681 ttaccagaag ataaaccaga tattcatcaa gttcatgaaa atgatttgat ggaaattatc 658741 agaaatatag ctggcgattt ggtagagagt gtcaagctag tcgatagctt tacgcatccg 658801 aaaactggga gaaaatctat gtgctacagg atcaactatc aatcaatgga cagaaatttg 658861 acaaacgccg aagttaacac tttgcaagac atggtgtgtt ctaaattggt aaaagaatac 658921 agcgtagaac tcagataggg atacggactc aaactagttg caggtgtttt accgcagctg 658981 tatatatctt gtaaatactt tgtcaggttc tttgtatcac ttcaatctat gttcatctat 659041 ctatctgttt ttcttaatta ctaagcattt gcggcaatgc gatgactaca taaaaaaaaa 659101 aaattcgaaa aatttcatga gccttattaa catgaagatt ctagtcaaca gtaggccatc 659161 tgtgtttcca ttaatcgctg catgtcatcg agcaagaaaa tcgtcatcct ctatggatcg 659221 gagacaggta acgcgcatga ttttgctaca atcttatccc atcgactaca tcgctggcat 659281 ttctcccata cattttgctc cattggtgat tatgacccac aggatatctt gaaatgcagg 659341 taccttttta ttatatgctc cacaacaggc caaggtgaat taccaaggaa tgtcaatgca 659401 ttaaaaggtg aaagacccgt cacgttctgg tcgtttttaa agagaaagaa tcttccgtcg 659461 aatttgctca accatattca aactgccatg cttggacttg gtgattcatc ttatcctaag 659521 tttaactacg gcattagaaa gctacatcag cgcattgtca cacaattggg tgctaatgaa 659581 ttattcgata gattggaggc tgacgaccag gctatggctg gtagcaataa gggtacaggt 659641 ctcggaattg aatcagtata ttttgaatat gaaaagaaag tcctaagctt tcttttaagt 659701 aagtacccca acagaaaggt caatggccaa ataattaaga gggaagaatt ggaccctgag 659761 gtttacctag agccagcatc ctacctacag ctttcagacg aacatgccaa tgaaaagttc 659821 actagcacca aggttatatt cgaaggtgat gaatcgttaa aggttggcag agttaatata 659881 aacaaaagga ttacatctga aggtcatttc caagacgtga ggcagttcaa gtttagtaat 659941 gtggacaaga ttcaagaaaa ctatgaaccc ggtgatacag taaccatata tccttgcaat 660001 acagatgagg atgtttcaag attcctagca aatcaaagcc attggttaga aattgcggac 660061 aaaccattga atttcaccag tggagttcct aatgatctta aggatggtgg attagttcgc 660121 ccgatgactt taaggaactt gttgaaatat cactgtgatt tcatgagcat tcctagaaca 660181 agttttttct tgaagatttg gacctttgca actgatgtaa ctaagatgga acgtggccaa 660241 gaacaactga atgatcaaag agaaaaattg cgccaatttg ctactgatca agatatgcag 660301 gacttatatg actactgtaa tagacccaga aggtcaattc ttgaagtact ggaagatttt 660361 atctccgtaa agttgccctg gaaatatgtg ctagattact tgcccatcat taaaccaagg 660421 tactactcta tatctagcgg ccctggggat cctaatattg aattaacagt tgcgatagta 660481 aaatataaaa ctatcttaag gaaaattcga agaggaattt gcactaacta cattgcacga 660541 ttgcaagagg gggaacagat aaggtataag ttacaaaata atcacataat caaaaaggaa 660601 tttttgaata aacctatgat tcttgtcgga ccgggtgtcg gtctagcacc attattatca 660661 gtggttaaag cggagatatc taaagatatc aaactcctct tcggttgtag atataaagat 660721 aaagattata tttataaaga tatgctggaa gattggttcc gtaagggcaa aattgcctta 660781 cattcatcct tttccagaga tgaggaaaat tcaccaggtg ttaaatatgt ccaagactac 660841 ttatggagat taggtgagga aataactaat ttggtagtta ataaagacgc cgtttttttc 660901 ttatgtggct catcaggtaa aatgcctatc caagtcagat taacattcat tgaaatgtta 660961 aaaaaatggg gcaattttag tgatgaagaa actgccaaaa aatacctgaa agaaatggaa 661021 aaatctgata gatatatcca ggaaacttgg tagtcgataa caagacttat cgcattataa 661081 tgttaaatag atacataatt aaaatcttgt catttgtgac aaacgtttag cactgttcaa 661141 actccctggt atgaaaccac aaccgcagtg acctgaaacc aaactgagcc ctttggtagt 661201 ctaaatggat tattagaggg gctatctgct acgaaatgtt ccaaagtgac aattctgcct 661261 acaaaccatt ctttcccctt cgtcaatcct ttttcgtcct ttaaaaaata tcttgtgctt 661321 tcttcaaaag ctgtaaatgc agcccaaggc ctcatcagtt tattcttgtc cctgccagat 661381 atactggctt gattgattac attactatgt atcaccgagg gagacgattg tatagacata 661441 gcatccaaag gcggtggagt tgataaatca acagatgaaa atgatgagct caatgatgag 661501 gtggaagacg acatagaccc gacagaatta acgttttctc gtgttggcaa aaataatgct 661561 aaatcgccaa tttgaaagtt cctcaaagtc accttttccc tttggaatct ctccaatagc 661621 gttctcttga tcttattttc tttagttaat tttttggcca aggtctcaat atccttgaat 661681 ctcctgataa cggcaacttc ataaagctta ttgtcatata attgagtgat attccccaga 661741 aaaatgcttt gctgtgtatc cttttcagat ccattggcaa ctgactttat taattcatac 661801 tcatctttca atttctggaa aaccggactt tttattagag aattatcatg tgcgtccagc 661861 atttgtgtgc tttcatccag tatattactt tgggcggttc cctttttcaa tcccttgact 661921 cgtctaattt ggatgttatt attattgtcg aaggttaaca gcaacccaat gttctccaaa 661981 atgaaaatat ttgtcgatat tatatcaaat attctatctt gcagagtctg tgtgtatgca 662041 gatatctggt tttccctacc tgggtcctca gcaagaggaa tggtttcgaa tttctcacct 662101 ttttccatcg agcttgagtt agtctcagcg taacttttct ctgaagtcac aatttgttta 662161 ccgagccttt caatatcagc cttcaacaaa ttgacctctt gttcatgctt cttattagat 662221 tcatccagat ccatttgcaa tcgttccctc gatttgctaa catcatcata gtcacctgtt 662281 agcttttcta tcttttcatt gtcttggcta attatatcat tcaattgctt tttgaaagag 662341 gcattgaggg taaaaatttc agttctatgc gattgttctt cattagttaa ccttgccaat 662401 tcttgattca aattagtcaa agtttcgcga taagctgtct tctccacctc tagatcactt 662461 atttttttcc ccatttccga aatttgcatt gattttcgat tattttcttc tttcaatagt 662521 tgaagttggt gtaatagatc atccacatta ctctctaact cttgaatttg atgattatta 662581 gcttgcgaaa cactatcaat gttcacttca gaaatattgg caggctctag taatacagat 662641 gctcccagga atttcttctt gtttatactc gtagcagaac cacgaaatgg cttaagatgg 662701 gtattgagaa caccttgagg ccaatggcct atgtcggaat attgaaactc atgtaatagc 662761 gattctaatt tttttattct tgttttgtat cctttgacta catcatcact tttcaaggca 662821 atagaccctt caggggaaat gctattgcca ttagaactat tattgttatt atttttgaaa 662881 ttggaatata ttatatgaaa tctcttcgtc tcaaaaagtg ttttcgaaag tagatcaatg 662941 atcggttcag aaacatctgt ttctttaatt tgcgtcatat aattatcaat ggcttgcgat 663001 acttttacca ggtcttggcg gtaatttgct atagaattct cattttcatc ttcctcatct 663061 tcatttggtg gagaagtatg agagtgatat tcgtttagac gtttgaaatc agaggaagac 663121 aatagatctt cgcaaaaaac agtcgcgatg gaaccgaaat ttttaaccca tttatttctt 663181 gttcgtaatt cattttgttt gaacaactct aaatcttgat taaaatttga gataaatgac 663241 aaaatttgtt ggaaccatga tagcctacga tatttttcga ttaaataaag cccatatatc 663301 agaggcaaat cttctacctg tgcaaattct acctcatatt tcttgtatag ctctaaatct 663361 ttattacatt cattcaataa tagtctttta atacctagga tttccatctg ggtgaatgct 663421 atgttaccca aaatggctac tgcatgcttt tgtagacttt tttttaaatc tattagttct 663481 cctatttgtg aatacagcgc ttgtgatata gtgaagagag ttttcactga ttctttttta 663541 tccttttcca acatcacatt catgcttttc aaaaattctt gactattgaa ttcttcttct 663601 tctttatcaa gtacatttct gcttcttgtt cgcatttctg ataccagtac ctcaaagctc 663661 tctgccattt ggtcttcaag ctcgaattta gattcattcg gggtaaacat ttgccgcagt 663721 cgatcgatgt ttactgttat aatatctcta aaacttgcat tttcgtcaat ttccctctta 663781 attttattca gcttaccatt gattgaatga tttagaatct ttacagattt ttcgttctcc 663841 aggagagatt caatattaat gaacttttgt aaagaatcac cctctaaagc agtcaactta 663901 ctcaaggtgt cattgaagca tttttcccat tttgaagtca taccattgtc taccagctga 663961 tttaaaaatt gaacgtttga gttatacaaa ctttctacat caaagcagta cagcttcaaa 664021 tattgtgagc aaacggttaa gccatcaaaa atacgcttaa tatgggctat tatgtctggt 664081 atgaggctct taaaataatg tacatctatt tctaaagcgc ttagccaacc aaggttcgtc 664141 gtcagtaagc tagttacgga atggtaattt aaacgcgaaa gatctacgtc tgcgtcctcc 664201 aaaggcgagg gcataggctt gatcataata gtatcgctac cttggtattg agatatatga 664261 ctattcttaa ttaaatattc cagagtctct gtcaagtcgt tggaattagg ggagttcatg 664321 ggattagaat ccttagacgt taaaagattt gttggtgtcg gtttactaac aagtgagaat 664381 agtcgtctgt cgtaaacgta aaaatcattt agagtaaaag acctattaat aagcagctct 664441 ttaaacatcg acggttttag tttgttacca taaggtagta gaatcagcag ctgatcggga 664501 ggaatcttcc atttcctagc aatgaactgt ttaaatttgt ccagggaaac gaaaaaatca 664561 acattcgtag ttatacattc tccagatatt gcatttatga tagtggctgt tgtctgcagt 664621 ggtgttattt cttgctgggt aggtgcagtg ctatattcat cagcgtctgc catgatgtat 664681 aaaagaaaat aaaagaagta ctttccgaac aacaacagta cactaaaata atcgttgttc 664741 aaaggaggac tactttggtt ctgatttgag aaaatggtac tcaaataagg gcatcgctat 664801 tatatagttc cattcctacc aagaaaccgg gtagccaaaa gcgataaaaa ggctctccat 664861 ggcaagcctt attaaaaata ataatcatga agaacaaagt ttcacaagag attacaagat 664921 aaaaaagcca ctactacaga aaaggcgttg ggtcaggaca tggaaatagt gtacaagcca 664981 ttggacatac gtaacgaaga gcagtttgct agtattaaaa aactaataga tgcggatcta 665041 tcagagccgt actcgatata cgtatatagg tatttcttga accaatggcc cgagttaacg 665101 tacattgccg ttgacaacaa gagtggaacg cctaacatac ccattggttg catagtgtgt 665161 aagatggacc cgcatagaaa cgtgagactg agaggatata taggaatgct agccgtagag 665221 tccacatacc gcgggcatgg catagcaaag aaactagtgg aaattgccat agataaaatg 665281 caaagggaac attgcgatga gatcatgtta gaaacagagg tggaaaattc ggcggctcta 665341 aacttatatg aaggaatggg tttcatcaga atgaaacgga tgttccgcta ctacttgaat 665401 gaaggggacg cctttaaact gatattgccg ttgactgaaa agagctgcac tcggtctacg 665461 ttcctaatgc atggccggct ggccacataa aaggaaaaac actcgatgat gataaaatat 665521 atattaataa tacaattttt ttatttattt atttaatcat atgtatagat atagaaaaag 665581 ggcagtagag aaaagaggaa tagaaaggag agagataata aagcaagttt caaaaagaac 665641 aagaggaaaa gaaattaaat cacacagaca aaaacgcggg gaggaagtat ccctaagcca 665701 aagtggcgtt atataactcc ttttcggatt catatctctt cttatcggcc tgggccttgg 665761 cctcgtaagg ctgcttttcc tctggcgtta gagccttcca cttctcaccc aacttcttgc 665821 cgacttgtcc aaatgtgata tctggatttt cagaacgaac aatatctctg ttttcgttag 665881 cgaaaaacat gtaggcggac aaagccctct taggggcatt tgggtccttc ttctttctag 665941 tggttctctt cttaggttct cttggggtga ccattgcgac tgtgctttac tatgtatagg 666001 gtagtcaatt gagcaaaaac aggaaaaaaa cacgtcccaa aacagtcctt ctttaacagt 666061 cggtaccagt aataaatact gtgttgtttg tttgcccacc gctaaataaa cgaacggcga 666121 aaaaaatagg cggcaaaagg cgggtgattc gaaaagtatc gcgcgcgacg aggcgtgagg 666181 gtagaattcg gcgccactaa tttgtgacac ttgaacagta tttaacgtcg tgcgatacat 666241 catatcgata gaaatgtaga cgtgctcaac gctccaagaa tgaattgcac acttacagat 666301 aataccagag ccataaatgt ggcctccaac ctcggtgctc ctcaacagag gacgattttt 666361 gccaaggaga gaatatccat cccaggatac tacgagataa tccaattcct gggcaaggga 666421 gcctatggga cagtgtgctc agtgaagttt aagggtcgaa gcccagctgc taggatagcg 666481 gtaaagaaga tcagcaacat ctttaataag gagatccttt tgaaaagggc catccgtgag 666541 ctaaaattca tgaacttctt caagggccat aaaaatattg taaatctaat cgatctagag 666601 atagtgacca gctcgcccta tgacggactg tattgctacc aggaactgat tgattatgat 666661 ttggcaaaag tcatacattc gtccgtgcag ctctcggagt ttcatatcaa atactttctt 666721 taccaaatcc tgtgtgggct aaagtacata cacagtgcag atgtcatcca ccgagatttg 666781 aagcctggga acatattgtg cacattgaat ggctgtttga agatctgcga ttttggtctc 666841 gctaggggta ttcatgccgg atttttcaag tgtcattcca ctgtgcagcc ccatataacc 666901 aactacgttg ctacaagatg gtatagggcg cctgagctgc ttctttccaa ccaaccgtat 666961 agtaagtccg tagacatatg ggctgtaggg tgcattcttg cagaattcta tgctcgaaag 667021 cctgttttca tggggcgtga ctccatgcac cagatatttg aaatcatcaa agtcttgggt 667081 actcctgata aagatattct gatcaagttt ggcaccatta aagcttggaa tctaggcaaa 667141 aacagtaata accctgtata taaaaaaatc ccatggtcca acattttccc ctttgcctcg 667201 catgaagcaa tcaatctcat agagtcatta cttcattggg actcaacaca taggttaaac 667261 gtggaacaag ctatatcaca tccgttccta aacgaggtgc ggaagccaga cgacgagcct 667321 gtttgccttc agggtccttt cgacttcacc tatgaatccg agttgaattc aatgtccaaa 667381 ttaagagact acttggttga agaagtgaaa aatttcaaaa ccgatttgtc ctcctcgtct 667441 ttatagtaac cactacacaa ataggtatat catgaagtta tattctgacc gtaacaattc 667501 ttctttcttt gacgtaaact ttatggcggg taacgctcaa atagtttctt gttaaccatt 667561 tcaaataaca ataagtatac aactaaacaa agtctgctac ttgttaaata taggagtata 667621 aacaagataa gcttgctact ttttcagcac aaccgccacc tctcgattgc atacaatgga 667681 ttacctaaaa ccagcgcaga aggggagaag acgtggtctt tccataaaca gtctttcgga 667741 gactcagcaa tctgctatga atagttccct ggaccatctt cagaatgact taaacaggat 667801 aaatcttcaa tggaatagaa tactgtcgga taacactaat cccttagaac tagcgctcgc 667861 atttttggat gatacatctg taggtctggg ccaccggtat gaagaattca atcaattaaa 667921 gtcacaaatt ggtagtcact tacaagatgt tgttaatgaa catagccaag tgttcaacac 667981 taatgtggct tcttacggaa aagcagtcag ttcgatcatg caggcccaag aacagacttt 668041 aaatctgaaa aattgtttaa aggaagctaa tgagaaaatc accactgata aaggttcttt 668101 acaggaatta aatgataata acttgaagta tacaaaaatg attgatgttt tagtcaatat 668161 tgaggagtta ttacagatac ccgaaaaaat tgaggagaac attagaaagg aaaatttcca 668221 tcaggtgcaa attctcctag aaaggggttt catattaatg aacaacaaat ctttgaagac 668281 agtggagatt ttaaagccta taaaccaaca acttgagtta caagaacatt tacttttcaa 668341 caatctgatt gaagaaattc acgacattat gtactccaaa tctaacaaaa caaattttac 668401 tcgagtaacc aataatgata tattcaaaat cataagcatt tcacataatg gatttacgag 668461 tttagaaaat tacctgtaca acatagtcaa tattgatatt atggaacact caaaaacgat 668521 aaacaagaac cttgaacaat tcattcatga ccaatcgtta aataaaggaa atatcatgct 668581 acaagaaaat gctgcgactc aagcaccatt ggcaccatct agaaaccaag aaaacgaagg 668641 atttaacaga atagggttcc tactaaaaac cataaataac atcaataaat tacctgttgc 668701 attcaatata ataacagaaa gggctaaaga ggagattcat aatataattg ttaaaagtac 668761 cgaatcaata cgttcgaagc acccttctct gcttaaaatg gctactagtt taaagaatga 668821 caaccatttt ggcctacccg tacaggatat actatcgatc attttaaggg aatgcttttg 668881 ggaaatattt ttgaaattac tgtatgctat tcagtgccat agggctattt ttgaaatgtc 668941 aaacattttg cagccaacgt cttccgcaaa gccagctttc aagttcaata aaatttgggg 669001 caaactgtta gatgaaatag aattattact tgtgaggtac atcaatgacc ctgaattgat 669061 atccagcaat aacggtagta ttaaaccaat taatggcgcg acaaataacg cacccacttt 669121 acctaaaagg aaaaatccta aaattttttc tttggagtat aacattgagg acaattcttc 669181 tgtaaaggat caagcttttg aactaaaggc tttgttgaaa gatatattcc ctggattttc 669241 tgtctcctca aacatggatt tagactctat ttatgtaaaa gatgaatcct tcgaacaaga 669301 tgagcctcta gtccctcctt ctgttttcaa catgaaggta attttagatc cgtttttgct 669361 gtttacgcaa tcgacatcta caattgttcc cagtgtctta acacaaaata ctatttcatc 669421 cctaaccttt ttcgatgatt atatgaataa aagttttctc ccaaagattc agatgactat 669481 ggattattta ttcacggttg aagtagaatc caataatccg tacgccttag agctatccga 669541 tgaaaatcat aacattttta aaacagcatt agattttcaa aggttatttt acaatttatt 669601 gaatgttttc aacacagcaa acacatttag agaaaaaata tcgtactgca ttctagatct 669661 tttgaatcat ttttataatt actacttggg gctatttaat tccttgattg gtacttctga 669721 tagacattta actaggaaaa taattacggc atggttgcag aatggtattt tgatggatca 669781 agaacaaaaa attctgaatg gggatgagac actctttcat gaagaatcca tagagttatt 669841 taaggaaata cctcatttct atcaagcggg taaaggtttg agcaaatctg atttattcaa 669901 taacttgaca ttggacacaa ttctgcagtt ttcggcaagc gtgttatgga tattaaactg 669961 gctgccaggc ttaaaaaagg ctatcaatat tgatgaagta agccaagaac ccatgttaga 670021 tgctgataga ttaaggagca gctggacatt ttctgaatca atggatttaa actattcgaa 670081 ccctagttcc agcccaaatt cattaggaaa tctaaaaatt ttattggatg ataaagcctc 670141 caaaaaattt gatgagacta tcgacggatt caaaaccttg aaattcaaac taatcactat 670201 actgaggttc aacattaggg ccttgtgtat atacgacatc gggtcttttt ttcaaaacac 670261 caaaatttgg aatatggatg tgggtagtat tgaattagat caaaatatag cttctctaat 670321 ttccgaatta agaaggactg aaagcaaatt gaaacaacag ttaccagaaa aggaaaaaaa 670381 ctccatattt attggtcttg atatagtcaa caactacgcc ttgattaagg gtgccaaatc 670441 cataaaagtt ttgaaccata acgggataaa gaaaatgttg agaaatgtaa atgtcttaca 670501 acatgcctat agaaatcttt cttctgaacc atcaaaaatt aatatgaacg tcacaatgaa 670561 tttttactct ttatgcggct ccagtgaagc tgaactattt gaatatataa aagacaatga 670621 attaccgcat tgttctgtcg aagatttgaa aaccatattg aggctgcagt ttagcgagga 670681 aatgcatcgt caattgaaga gacaaagcac tagctcaact aagggttcca taaaaccttc 670741 caataagagg tacactgaag ctttggagaa actaagtaac ctcgaaaaag agcagtcgaa 670801 agaaggagcc cgcaccaaga ttggaaaact taaaagcaaa ttgaatgctg tccatactgc 670861 aaacgaaaaa tgacattttt agtttgtgta aaattaattt gataaataaa tgaatgaaaa 670921 tgatcaataa taagcgaata actatatttt taattacctt atttttacaa tatttttcac 670981 ttgcactttt attttatttt cagcgcgcag ctcgtcttgt tctgttgaaa ttcaaagata 671041 cctgaaggaa cattacaaca tcaatcaaca cttgagtaga aatatacacg atccaataaa 671101 atatactgaa gcgaagcaat cagaaatgga tgcaatatct gatccaacgt ttaagcatgc 671161 tagatcaaga aaacaggtta ctgaagaatc accatctttg cttaccgtta ttatagaaat 671221 tgcaccaaag ttatggacaa cttttgatga ggaaggaaat gagaaaggaa gtataataaa 671281 ggttttagag gcattgatag tatttctcaa tgctcactta gcgttcaata gcgccaacaa 671341 agtagcagtc attgctgcat actctcaggg aatcaaatat ttatacccag agagcacatc 671401 tgctctaaaa gcctctgaat ctgaaaataa aacccgtagt gatcttaaga ttattaactc 671461 agatatgtat agacgtttta gaaacgttga tgagacgcta gtggaagaaa tatataaact 671521 atttgagtta gaaaagaaac aaatcgaaca aaatagtcaa aggagcacgc tagcaggtgc 671581 catgtcagct gggctgactt atgtaaacag aatatcaaaa gagtcagtaa ctacctcatt 671641 aaaatcaagg ctacttgttc ttacgtgcgg gagtggcagt agtaaagatg aaattttcca 671701 atacatccct ataatgaact gtattttttc cgcaacaaaa atgaaatgtc ccattgatgt 671761 cgtaaagatt ggtggttcta aggaaagcac gtttttacag caaacgacgg atgccacaaa 671821 tggcgtttat ttacatgttg aatctacaga agggctaatt caatatttag caactgcaat 671881 gtttattgat ccgtcgttaa gacctataat tgttaagcca aaccatggat ctgtagattt 671941 taggacatca tgctatttaa cagggagagt tgttgccgtt ggattcatct gttcagtttg 672001 cctatgtgtc ttatcaatca taccgcccgg aaataaatgt cctgcttgtg attctcaatt 672061 tgatgagcac gtaattgcca agttgaagag gaaaccagtt gttccaaggt tgaaagccaa 672121 aaagaaggtg acgaaaccat gaacgaaagg aatgaacatt atccgtttca agcaggtaac 672181 cttcgtcaca atgcatcgta ataatacata aaaaaaaatt agctttaagc acatgtatat 672241 tggacattcc acagaaaaaa aaaagctttt gatgtgatta gcttaagacg ttgtgtcatc 672301 tttgaactgt tttgacttca atcatatcga atttgataat ataactatct atgtactgtc 672361 tgggtgcatc gctgttgttg cttcggtaga tttattagtt cgctttggat aatgtatcat 672421 acaataacat tgccaacatc catcataaca gaaacattag gtgataaaca atgaaaagag 672481 gagaaagcca ggcgcctgat gccatctttg gtcaatctcg tgcatttgca ctatctgatt 672541 cttcagtgaa tcctgatgtc attgaatatc ttaaaagtgt taggcaagaa gcactaagaa 672601 ccaacgccat atcgattaag aatcatatga atctgcaaaa gaggacgcgt cacaaatcaa 672661 gcatgtacga tgatgaggat gagggggccc ttaaaaggca cgccatctcg ccatccttga 672721 ttaggcttca aaggaatgta gaaatatggg taaggtggtt taactctgtg aaggcgacgg 672781 tgttgactaa tgcctacgag tttaccggtt atgaggacga aacactggat cttttattgc 672841 ttttcttaaa gaattatctc gaagatatgc ccagcaaatg tactacagtt gaaaaaatta 672901 taagtgtcct aaatcagcat tcctttcctg agaaggcaga agagaaggaa gaaaatcttc 672961 agattgatga ggaatgggcg aagaatattt tggtacggct ggaaaaaacc aagattgaca 673021 gtgttgagga tgtaaaaaaa gtaatcactg aaggagataa acatgaacta gttggataca 673081 accagtggtt ccaatacctt ataaacaatg aaccgcagca tactactttt catgaaaaga 673141 ttacctctaa gcaactttgg gttctgatca agtatatgtc gaatacatgg ataaaagaaa 673201 tacacaagaa aggaaggcat tatcgtcggc tgcaagattg gctattctac atactggtac 673261 atacacccga aagagtcacg gcagaatata caagcatctt gagagatctt ggaaagaaat 673321 gccttgaact gattcaaaag aagccagttg aagcacatga gaataaaata acactcccga 673381 aggagatggc ggaattgaat gttgagatac cagccgcggt ggagaatatg acgataactg 673441 agctgacagt gtctgttata gcagtgaact atggtcaaaa agacttgata gaataatgta 673501 aataaatttc ttatgtagtt ttttacagga agtaaaaagt gttattactt tgattgactc 673561 attcttacat ttactgatag gccgaagata agcggcgccc taagaaaact cgagcgcaaa 673621 ttgtcagcga tgatgtagcc atgctatagc atcaatcaat gtcaataagc taataacaac 673681 tatcatctat actccaacgc agctctcttg tttaggtttc tcgtcaatca aattcgcatc 673741 acgaagaagt atgtctgaag aatttccatc tcctcaacta atcgatgatt tggaagaaca 673801 tccacagcat gataatgctc gagtcgtgaa agatttgctt gcaggtacag cgggtggtat 673861 tgcgcaagtg ctagtgggcc agccctttga tacgacaaaa gttaggttac aaacatcgag 673921 caccccaaca acagccatgg aagtcgtcag aaagctgctt gccaatgaag ggcctcgcgg 673981 gttttacaaa ggaactctga cgccattaat tggtgttggt gcatgtgttt cattacaatt 674041 tggtgttaat gaagctatga agagattttt tcatcatcgc aatgctgata tgtcatcgac 674101 tttgtcattg ccacagtatt acgcatgtgg tgtcacaggc ggtatagtaa actcattctt 674161 ggcgtcccca attgagcatg tcaggattcg cttgcaaaca cagactggct caggcaccaa 674221 cgcagaattc aagggtcctt tggaatgcat caaaaaatta agacataaca aggccttgct 674281 acgtggttta acacctacaa tattgagaga aggtcatgga tgtggcacat atttcttagt 674341 gtatgaagcg ttgattgcta accaaatgaa caaaagacgt ggactagaga gaaaggacat 674401 tcctgcatgg aaactttgta tttttggagc attgtctggc actgccttat ggttgatggt 674461 atatccatta gatgtcatca agtctgtcat gcaaacggat aatttacaaa agcctaaatt 674521 tggtaattct atttccagtg tagccaagac tttatatgcc aatggaggga taggcgcttt 674581 tttcaaaggg tttggtccta ccatgctaag agctgctccc gccaatggtg ccacttttgc 674641 tacttttgaa ttagcgatga ggttattggg ttgataattc ctatagaatt tatgagccat 674701 cgtttaagaa aatagtacaa tataatgtat aacttgaaac tctatcttct tatattcaat 674761 agatgctact atgcgtacat atatatggtg agtgtgtgtg tttatatatg cgtagtaatc 674821 actcggcaat gtggaattgt taccgtgata gccttcatgc ttactcttcc aaccttctta 674881 gcaagtattc cacctcaact tccttagtga taggtataac aatttcctta taaattttta 674941 ccaaatattc tggagtaatc cttctttcac ctgactcgtt ggtagggtcc acaccataga 675001 cttcagcctt cttagttaat ctttctagaa tcttttcttc aacggcagaa ttggtgatat 675061 tcttcattat cccctcgaca tctttacttt tgatcagctt tgtgtatagc gggatatccg 675121 attggaactt ggcttcagca acaaacttgc caaagtggat tctcctactc aagctttgca 675181 aacattctat atctctagtg gcaacagaac cgaagttatt cttatcatca ccatctcttt 675241 tcgaaattaa tggtataatc ttttcaatat aaactttttt tattttatca ttgtaattaa 675301 cttctggggc ataaggcgcc aaaatttgtg ggtagttaat gctcggtaag aatgatttct 675361 gaatcttgtc aggaaagaag ggagtttcat caggtgattc gaatcttctg atgcgagaat 675421 gcgcaatttc aagatttgaa agagcccaat ccaagaaaga tcctttaaaa ttcggaattt 675481 ctaaacctgg atggtttgcc tcataaactg aaggacatgt ggcgaaatgc gacctctcaa 675541 taaatttgaa gatgatcgaa tcctccattc taactaattc atctctaata ttttgtagat 675601 ttaaaacagt ttctggtttt gtgaaatcca tatcttatac caattttatg caggatgctg 675661 agtgctattt gttagcaaaa cggaatcgat gtttcaactt ttcaatactt tttttcttct 675721 tttcttcgaa cttcgaagat tatagagatc cattgaaaat ttacgataaa ggaaatgcaa 675781 cacgaagttt gaaaaaaagt tgatattgaa aaaaaaaaaa aaagagaacc aaaaaaaaat 675841 taaaaaacgt gaaaacgatg gtttaacaac ttttttcgaa tttggtatac gtggaaaaac 675901 gaatgtatag atgcattttt aaagaatata tataaaattt agtaattgta ttccgcgagc 675961 ggcgcaatag gtgatttcat ttagctgctt tcagtttgcg tatcatttct tcattgatct 676021 tggcttctct atctaaatcc tctttcgact tgtaaagtcc ccaagttcta aaccataaga 676081 accgcctcaa tctggaaaat ttgtcagtat caagaccata attcgtgtat gactgaatca 676141 aatgtaatcc actttcgtca tgagtaaatt cggccttgct cagagactcc tggattttgg 676201 ctaacaacgc agtcccttcg atgcatatag ctaggccaca aattatgcca ataacggtcc 676261 atgggttgat gttttcttga attctttcgt ttttcatgct atttgcgtct tcccaagtcc 676321 cagcgttcca gtattcatac tgcgcgttag agtggtagcc ataagagccg gcatattggt 676381 aattttcagt attaacgtta gaacgtggtg aatacgatgt ggtccagcct tgcctcgttg 676441 tgtcatatac gatctttttc tttgggtcac aaagaatatc atatgcttga gagatgactt 676501 taaatctatg tagtttttcg cttgatgtta gcagcagcgg tgatttacta tcactgttgg 676561 taaccttttc tgagctaaat atttgaatgt tatcggaatg gtcagggtgg tacaatttta 676621 cataacgatg atattttttt tttaacgact tcttgtccag tttaggattt ccagatccgg 676681 cctttggaat gccaaaaata tcatagggag ttggatctgc caactcaggc cattgttcat 676741 cccttatcgt aagttttcta ttgccatttt tatcgttcgc tgtagcatac ttagctataa 676801 aagtgatttg tgggggacac ttttctacac atgataagtg ccacttgaat aaaaatgggt 676861 atacgaactt atggtgtagc ataacaaata tattgcaagt agtgacctat ggtgtgtaga 676921 tatacgtaca gttagttacg agcctaaaga cacaacgtgt ttgttaatta tactgtcgct 676981 gtaatatctt ctcttccatt atcaccggtc attccttgca ggggcggtag tacccggaga 677041 ccctgaactt ttcttttttt ttttgcgaaa ttaaaaagtt cattttcaat tcgacaatga 677101 gatctacaag ccattgtttt atgttgatga gagccagctt aaagagttaa aaatttcata 677161 gctaatggtg acagggggaa tggcaagcaa gtgggatcag aagggtatgg acattgccta 677221 tgaggaggcg gccttaggtt acaaagaggg tggtgttcct attggcggat gtcttatcaa 677281 taacaaagac ggaagtgttc tcggtcgtgg tcacaacatg agatttcaaa agggatccgc 677341 cacactacat ggtgagatct ccactttgga aaactgtggg agattagagg gcaaagtgta 677401 caaagatacc actttgtata cgacgctgtc tccatgcgac atgtgtacag gtgccatcat 677461 catgtatggt attccacgct gtgttgtcgg tgagaacgtt aatttcaaaa gtaagggcga 677521 gaaatattta caaactagag gtcacgaggt tgttgttgtt gacgatgaga ggtgtaaaaa 677581 gatcatgaaa caatttatcg atgaaagacc tcaggattgg tttgaagata ttggtgagta 677641 gagcacgcag cacgctgtat ttacgtattt aattttatat atttgtgcat acactactag 677701 ggaagacttg aaaaaaacct aggaaatgaa aaaacgacac aggaagtccc gtatttacta 677761 ttttttcctt ccttttgatg gggcagggcg gaaatagagg ataggataag cctactgctt 677821 agctgtttcc gtctctactt cggtagttgt ctcaattgtc gtttcagtat tacctttaga 677881 gccgctagac gatggttgag ctatttgttg agggaaaact aagttcatgt aacacacgca 677941 taacccgatt aaactcatga atagcttgat tgcaggaggc tggtccattg gagatggtgc 678001 cttattttcc ttataggcaa cgatgatgtc ttcgtcggtg ttcaggtagt agtgtacact 678061 ctgaatcagg gagaaccagg caatgaactt gttcctcaag aaaatagcgg ccataggcat 678121 ggattggtta accacaccag atatgcttgg tgtggcagaa tatagtcctt ttggtggcgc 678181 aattttcttg tacctgtggt agaaagggag cggttgaact gttagtatat attggcaata 678241 tcagcaaatt tgaaagaaaa ttgtcggtga aaaacatacg aaacacaaag gtcgggcctt 678301 gcaacgttat tcaaagtcat tgtttagttg aggaggtagc agcggagtat atgtattcct 678361 tttttttgcc tatggatgtt gtaccatgcc cattctgctc aagcttttgt taaaattatt 678421 tttcagtatt ttttcttcca tgttgcgcgt tacgagaaca gaagcgacag ataaccgcaa 678481 tcatacaact agcgctactg cggggtgtaa aaagcacaag aactaagcca agatcacaac 678541 agttatcgat aaaatagcag tgtttgcatg gccattgaga aggacaacat tggcgtgcgc 678601 gccaatgttg tctcaccatg tagctccaaa cgagttgtaa gagacggacc gctcacgctt 678661 ccgaagcggt cagaaaacgc ttcccagtat gcagttgacc tacattcaac ctgcaaatat 678721 tgctttgctt caagaaatga ttacacagac gtctattttc ttctacataa tgcacgaaac 678781 ttgggcattt agtcatgtag ccgcctagcg agcctgggtg ccgtcctatc tcctttgttc 678841 gtgcaaagag acaggaacac acactgcgtt ctcttgcggc cggtctggcg gactcagggg 678901 tgcggcgttt gcttaaccgg agggaataat aaaatcgggg tgacgcaagt atgaagtcat 678961 gtgtgcttag caattacgta gagggattag aaataatagt gtgcggttat cggaaccggc 679021 tcttgttccc gtttagagca acccaggtgc aggcgtactt taaagtattt tctttctttt 679081 ttttcctgct acttacgcta ggagctgccg cagctgcaaa gccgacgtcg gagaggcagg 679141 tgatcttcgg ctcggccgac aaatcccctg gatatcattg gcctgtcgag gtatcggccg 679201 cgtggaacta ccgggaatta ctatgcaaaa caattggaaa tctggtagga aaaccttgtt 679261 ctagaacttg gcgattgctg acaaagaaga aaagggccta ttgttgctgc ctcttttgtt 679321 gttcttcctc gtattgtctt gccggtgttc tttgtgtctt ttgtgtgtag gttcttacta 679381 ttatagtgct ctttgctatt atattttctt cgttttcact ttgcgtaatg taacggtctt 679441 aaacaaagtt tttttttttt cgctcttgca ttttcctttt ctgctctatc ttatttgcta 679501 attgtagttt cagaagtttt acttaaatat agcactattt tccagtttta atgtttcttc 679561 tcattgcttt cttttataat tttcgcatat aattatacat ttacggtgtc ttaactctcc 679621 ctcttcaccc ctcattattc cagaaaatac taatacttct tcacacaaaa gaacgcagtt 679681 agacaatcaa caatgaatcc taaatcctct acacctaaga ttccaagacc caagaacgca 679741 tttattctgt tcagacagca ctaccacagg atcttaatag acgaatggac cgctcaaggt 679801 gtggaaatac cccataattc aaacatttct aaaattattg gtacgaagtg gaagggctta 679861 caaccggaag ataaggcaca ctgggaaaat ctagcggaga aggagaaact agaacatgaa 679921 aggaagtatc ctgaatacaa atacaagccg gtaagaaagt ctaagaagaa gcaactactt 679981 ttgaaggaaa tcgagcaaca gcagcagcaa caacagaaag aacagcagca gcagaaacag 680041 tcacaaccgc aattacaaca gccctttaac aacaatatag ttcttatgaa aagagcacat 680101 tctctttcac catcttcctc ggtgtcaagc tcgaacagct atcagttcca attgaacaat 680161 gatcttaaga ggttgcctat tccttctgtt aatacttcta actatatggt ctccagatct 680221 ttaagtggac tacctttgac gcatgataag acggcaagag acctaccaca gctgtcatct 680281 caactaaatt ctattccata ttactcagct ccacacgacc cttcaacgag acatcattac 680341 ctcaacgtcg ctcaagctca accaagggct aactcgaccc ctcaattgcc ctttatttca 680401 tccattatca acaacagcag tcaaacaccg gtaactacaa ctaccacatc cacaacaact 680461 gcgacatctt ctcctgggaa attctcctct tctccgaact cctctgtact ggagaacaac 680521 agattaaaca gtatcaacaa ttcaaatcaa tatttacctc cccctctatt accttctctg 680581 caagattttc aactggatca gtaccagcag ctaaagcaga tgggaccaac ttatattgtc 680641 aaaccactgt ctcacaccag gaacaatcta ttgtccacaa ctacccctac gcatcatcac 680701 attcctcata taccaaacca aaacattcct ctacatcaaa ttataaactc aagcaacact 680761 gaggtcaccg ctaaaactag cctagtttct ccgaaatgat tttttttttc catttcttct 680821 ttccgttata ttatattata ctatattccc tttaactaaa aatttatgca tttggctcct 680881 gtttaataaa agtttaaatc gcctcaaaag aacaattgaa aaatatgtaa aataacagca 680941 aataaaagtc aaaattaaaa caaagtaccc agagacaaaa aagaaagaaa agaaaaaaga 681001 aacagtctac aaattctatt tgaatatata aaattatatt ctcaattttc acgtatatat 681061 tcacctcaca aataatatca ttcctttaaa aaaaaatatg tattattgta taatgtttca 681121 gcatagtcgt tttttaagcc ctttttttta aacttaaaaa acaaatcaat gagatattgt 681181 atacctatat tatcgataat aaagcgacga ggatggactg caagatattg gtgttaggcg 681241 caggtggtct aggatgcgaa atcctgaaga atttgacaat gttaagcttt gttaaacagg 681301 ttcatattgt agatatagac acaatcgagc taaccaacct taatagacaa tttctttttt 681361 gtgataagga cataggcaaa ccgaaagctc aagtggcagc ccagtatgta aacacgcggt 681421 tccctcaatt ggaagttgtg gcgcacgtac aggacctgac cactttgccc ccgagctttt 681481 acaaagactt ccagttcata atctcggggc tggacgccat tgaacctcgt cgcttcatca 681541 atgagactct cgtgaagctt accttggagt ccaattatga aatttgcatc ccgttcatag 681601 atggtggaac agaggggctc aagggacatg taaaaacaat cattccaggc atcactgcat 681661 gctgggagtg ctccattgat accttgccct cgcagcagga tactgtgcca atgtgtacaa 681721 tcgccaacaa tcctcgctgc attgagcatg ttgtggagta tgtctcaact atacaatacc 681781 ctgatttaaa tattgagtct acggcggata tggaatttct gctggagaag tgctgcgaaa 681841 gggctgccca atttagcatc tcaacagaaa aattatcaac aagttttatc ctgggtataa 681901 taaagagtat catacctagt gtaagcacta cgaatgcgat ggttgcagcg acatgctgta 681961 cgcagatggt taagatttat aatgatttaa tcgacctgga aaacggcaat aatttcactt 682021 tgattaactg ctcagaaggg tgttttatgt acagtttcaa gttcgagcgg ttacccgact 682081 gtactgtttg ttcaaattcc aattccaact agtattacta atgaataata ccatccgccg 682141 gtgtcacttg tttaaacatc ttgcaagtaa gtcgagatcc tagagagcct tgtacatgtg 682201 attgcacagt aaagaaggta tgcaggctaa attattgttt accagactaa actttagacg 682261 tccctccaca actttacgcc agtttcccct aacatgtttt ttatttcata gcaaagcatt 682321 ttactcggat ctggtcacta aggagccgtt gatcacaccg aaaagaataa taaataagac 682381 gcctgggtta aacttatcta tttctgagag ggcttccaac agactagctg agatctaccg 682441 caatagtaag gaaaatttaa gaattagtgt ggaaagtggt ggatgtcacg gtttccagta 682501 caatctaact ctagaacccg ctaccaagcc agatattaag aatgatgtca aagacaagga 682561 gttttcagac gaccttgacg atgatgattc caaggatata atatacgtgt tacccgaaga 682621 taagggtcga gtgataattg atagtaaatc actaaacatt ttgaataaca ctacactgac 682681 atacactaat gagttgatcg gttcttcgtt caaaatcatc aatggtagcc taaaaagtag 682741 ttgtggttgt ggaagtagtt ttgatattga aaattaagct gtattatatt catccctgta 682801 tatagcatgc ccagctgcca agcatttttt tacttaattg tctctattat atatttgaaa 682861 acctagcaag agcattacgg gataaaacgc tgcggcgttc gcattattaa tttgtattca 682921 aacgactaat taaaactatc ttacagttcg taaaacttca taagttcgac catatctcta 682981 tccttattgt cattccttaa cattttcatt cgagaacttc cttccatctc atatatccaa 683041 tactgatagt tctcttcatt atacatttca acaagatcat gttcacgtat aaattgttca 683101 gaatcatcac catcacagac atcaaatgga tcgatttgga acgaattatt gtcaccacat 683161 cttaagttgg aaaactgctt tgtaacacac caagtcaagt acgtataaaa tctactcatt 683221 agtaaatcgt tgtacccacc ccctccaagt aggaatatgt gcgctcgagg ataacttttc 683281 atgatattta tgatgattcg agaaagccct cgtattgtta gctgccattc attgaatcta 683341 tcacccagaa gcccatcacc accacattca attattaagg cctcaggttc gtgtctttct 683401 attagaggat tgacgatttt ggatgcgatc aattccaagt agttgtcatc acaaccatgc 683461 tttaaaggaa tattaaccac gttcttatcc tttcttgaat cacttaaaga accagttcca 683521 ggaaaaaaac caggctcgta gagatgtact gaaattgtct gtatttgttt agaatattgg 683581 aaagcctttt ctacaccgtc accatgatgc aagtcgaagt caacgtacgt gattttattt 683641 agctttgctt tgcgcaatct ctgtattaac agtaccacgt catttatata gcagaatccg 683701 cttgccctct gtttaaaggc atgatgtctt ccaccatccc aatttatacc gataagacgt 683761 tctgtaggcg atagatgatc caacaagttt aaagtcgcac ctgtaataac ttgacagtac 683821 ataggaaggt atgaaaaaat cgggcaatct ccctctaaat tatactgttt tgtttcagaa 683881 tttaaaatat aagtatctgt tggtttatca ttggtgggca cctcactgtt attaatacag 683941 tccatattat tttcgagcgc ttgtgagtga ttcagataat aattatagag attctctcta 684001 gtggtgaatc tctgaagatc ttgcgatgga ttgtagtcga ttttttcgtt ccaattatcg 684061 gccaattcac tcaactcact ccatttggac tctaccatgg gattatttac atcttgtgcc 684121 atcattttat tgaatctgcc atttatcaaa taatcgatat atgatttcga atggaactcc 684181 agcagatcat cctttctggc gtagggaaat gttagcactt cgtcaaagtg ctggagaaga 684241 tcgtacgcgt ttattaggga atatgtcagc tgcgattttt gatgattgtt acatgggagt 684301 aaatctgcta cttgagactg aaatattgac gttgatatga ccaatttcga catagcgttt 684361 ttctaaaatg gacaggtgtt tattaattca tattacagta catacacctt ttttttactt 684421 tttgtttctt tattaatttt ttagtttttt tcatattcta ttttattata agtagtaata 684481 tgaagaaatt tcccaagcaa agctcaataa aattatttag ctaaacaaac atatgcatat 684541 atatgtatat tctccctaat ttaattcctt ggctgcccag gttggtagaa caaaggaagc 684601 ttcgtgaatt ttcttgttat agtatctgta taattcagcc tccttctcat cagagatttc 684661 acgtagtggc ttcttgacat tgcaagtttt atctttggag caaaccataa aaccaatcgt 684721 accagttggg taagttggaa tagtaacgaa agagtattct gcaactggga aaacttcaga 684781 acaggctttc tttaagtcct taatgattgg caagtgaatc cacatacttt ctgcttgtgt 684841 agtgattaca cccttttctg tcaacgcact gttcaacaat tggaaatatt ccttttggaa 684901 aagggtttca gctggacctt ctgggtcaga agagtcagta atgattacgt caaatgtgtt 684961 ttggtaatct cttaaaaatt ggaaaccatc accaatgtgg gtcttaacct ttgggtgaga 685021 ataagaggca gccatttctg gtaggtactc ctttgatagt ctaataacag cttcatcaat 685081 gtcacataac caggcttcct caacggaatc atgcttgaca acctctctca aaacaccacc 685141 atcaccccca ccaataacaa gaaccttctt aggatttgga tgggaattca aggcaagatg 685201 ggcaatcatt tcttggtagg caaattcatc cctttcggtg gcttgaatta cattatctaa 685261 aactagaaca ttaccatatg tagtggattt gaagatcaaa acgtcttgat attttgactt 685321 ctcatggtgt aaaactttct ccacttttaa agtcatggcc tggcctggcc acatggtatc 685381 agaaatttct ctgaaccagc cgtctacaat agttgggtga gtgatttctt gtgccattag 685441 atttattgct tattagtgtt tgctcttctt gactgaacta ctatgtgaag cgtacaagat 685501 actaaattac taagtcagtt ttatatcaca gctattcctt atctcatgcc aatagcattt 685561 ttagagaaaa aaatgaaagg tgaaaaaatt ttttttctca agcaaagaaa tgaggagttc 685621 ctgaaatcat gcaggtgcag aatattggtg tagagaatcg cgtttgtata ttgtcttaat 685681 cctgtactta cgagtaggta tttgatgttt taaaaattgc aaatgtactt tttgcgaaat 685741 cttgcaacat tttttttgtc aggatgtaat tgcaactaat taatttttca aaacttaaaa 685801 tgaaggttac ctattaagga acgtttgtgt ttgaaaaaga actcctaatc aaaagcaaag 685861 aaaacataga acaaaagcca acaaaactct tttggagatg gtagaaggag actcttatgt 685921 ggagacttta gactccatga ttgaattatt caaggattac aaacctggtt ccataacttt 685981 ggagaatata acacgacttt gtcaaacttt gggtctcgag tccttcacag aagaattgag 686041 taatgaactt tcaagattat cgacggcatc taaaattatc gtgatagatg ttgactacaa 686101 taagaagcaa gacagaattc aggacgttaa actcgtacta gcatctaatt ttgataattt 686161 tgactacttt aaccaacgag atggagagca tgaaaaaagc aacattcttc taaattcctt 686221 aacaaagtat cctgatttga aagcttttca taacaatttg aagtttctat atctgttaga 686281 tgcatattcc cacatcgagt ccgattctac ctcccataat aatgggtctt ctgacaaaag 686341 cttagattca agcaacgcat catttaacaa ccaaggtaaa cttgatcttt ttaagtattt 686401 cacggaacta tcacactata taagacaatg tttccaagac aattgttgcg actttaaagt 686461 caggaccaat ttgaatgata aatttggaat atatatttta acccagggca tcaatggtaa 686521 ggaagtgcct ttagccaaaa tttatttaga agaaaacaaa agcgattcac aatacaggtt 686581 ctatgagtac atatattcac aagaaaccaa atcttggata aatgaatctg ctgagaattt 686641 ttctaacggc atttccttgg ttatggaaat agtagcaaac gctaaggaaa gtaactatac 686701 agacttaatt tggtttcctg aggatttcat atcaccggaa cttattatag ataaagttac 686761 atgttcatca aactcatctt cttcgccacc tataattgat ttattttcga acaataacta 686821 caatagtaga atacaactga tgaacgattt tacaacaaaa ttaatcaata ttaaaaaatt 686881 tgacataagt aatgacaatc tagatctaat ctctgagata ctaaaatggg ttcaatggtc 686941 gaggatagta cttcaaaatg tttttaaact ggtctccaca cctagttcaa attcaaattc 687001 atcggaactt gaacctgact atcaagctcc attctccacc tcgactaaag acaaaaattc 687061 ttcaacatct aacactgagc caattccaag aagtaacaga catggaagtg tagtagaggc 687121 ctctagaaga aggcgttctt caactaataa aagcaaacgt cccagtataa ctgaagcaat 687181 gatgcttaaa gaagagggtt tacagcaatt taatttgcac gaaattttat ctgaacccgc 687241 aatagaggag gaaaatggag acagcatcaa agagcactct acaactatgg atggtgccaa 687301 tgacctcgga ttcaccgcct ctgtttcgaa tcaagaaaat gcaggaactg atattgtgat 687361 ggaagatcat ggtgtactgc aaggcactag tcaaaattat ggtactgcaa cagcggatga 687421 cgcagacata gaaatgaaag acgtcagttc taagcctagt aaacctgaat cgtcggtctt 687481 acaactaatt gtaagtgaag atcatatcat tctcgacact atttcagaat gtaacttgta 687541 tgatgatgta aaatgctgga gtaaatttat tgaaaaattt caggatatcg ttagctaagg 687601 aggtacggag tggctcaaat acacattgtg gaccgtacac tcgatggagt ttaggtttac 687661 gtacaccttc tagtgcaagg tgcatgcttt tcatacctca tatgactgag tttgtttagt 687721 gtggcctata ttctaaaaaa gataaacgtt agaataaatg agcttgcgaa ctgagccatt 687781 taccggtcat ttgccaatat atataatcaa ggacatctct atcattgtga gaaatactaa 687841 aaatgtagga aaaaggttaa aacaagaacc actaacacgc tagataggta gataggtagg 687901 taggaggagg tcgatattat tactgcatat atatattttt ttccattctg cgttttcttg 687961 ctgcagcgta tttatgtatc aagatcccgg ggcagctgta agtgtactgt ctagaaaata 688021 aatcagcagg ccgcttgcta cttcagtaaa aaagagagta gaaactggaa atttttttgg 688081 cagtcaaaaa tttaatatat aaaaaaggcc ctttctgttt taagtgcatt tattaaatgt 688141 ttccagttcc aagacgattg gcaacggaat tatgcaaaac ggcacagaag acaaaagcaa 688201 tattcctgct cgtagtaatg atgatgtatt gccgccgtta gccgtcagac ttactatgaa 688261 agtaatgcga ttaattttca tcggaaaaat gtttgcatat tcatttgtac cctttccccc 688321 atttaaactt ttgacatttg ataatactgt gggctggttc gtagcatatt cagcgatcgt 688381 ttctatttgg gggtttgctg tgtggatgga aagaggatat agacataaga ttaatctact 688441 gcctccaaga tgtacgaaga taagatgctc tcgctgcaat acaagaataa gatcccccaa 688501 ttggttcaaa tataagaatt ggttatattt tttcctatta tacgtttctc taaccacttc 688561 taacttaata attcaactgg cctcttttat gacagaaatg agtcgtcggg gtataagcgt 688621 tcctggaacg aaggatccag gcaagagaga ttatttaggg cttatcatac caatgcgatt 688681 cattggtgca tttatccatt acatgacggc taatttattc aaagagtatt atttacataa 688741 cggcccacta gaaaagaatg atagaccttc taccgatgag aagacatcag agaatgaaac 688801 gctatagctt aacctcgatt aaaattaagt tcagtatgcc ataggtgcgt ttattacatg 688861 ttttttaaca acacttcaat atttctttct ctgtattttt caatagggaa caaaatgtac 688921 tattttctcc atgaggcctg aaatagcaaa tgtactcccg cagttaataa atgtacggac 688981 agcttttcat agccaattaa aagcagttta tatctctttc ctagcggatc acatctaatg 689041 gttgtccaac ttcccttgga ttaagaaata ggtgaataac gggatagttt ttgaggatcc 689101 attattgata gaggttataa ttttagacag gcaaaatatt ctagcacttc tcgagggcat 689161 aggcatccct aaaagggaat caataatttt acataatgat attaccatat cttttatact 689221 ttcttgagat ctggagaatt ttgtaaaatt gttgggattc catagtcgat aatattatat 689281 atacagaata tgctagaagt tccaatcatt acactttaac ttcaataaaa aatttggcga 689341 ctacttccca atctttatgt catcttcttg catcgtatat gacaatatgt aacagtaata 689401 tgaataatag tcaaaaaata atatataata ttcattccaa cactcttagt gtccctagct 689461 agaattactt ctgctagtga aacactcatc atcaatataa ggaaattaat tttagtcaga 689521 tgtttttaat accttccgtt ttctaacact accagattat tttgggcact atggccgagt 689581 ggttaaggcg acagacttga aatctgttgg gctctgcccg cgctggttca aatcctgctg 689641 gtgtcgtatt attttttgaa attatttttc aataaccacc atgtcagcac caggttcttt 689701 tacaattata caaacacaca tatctcaaaa tcactcaaga ggtcatggac caatatggca 689761 acttgctacg aaagtcatac ggtaacatat cagcttgtct aaacatacca tactttaccc 689821 atttttttgt gcttgttata tggcgccata aattgctcga acatggtcat gtgatgcaaa 689881 acattgtatt acccttcttt attgattttt cgacaatcca ccaattctaa ctacgaaact 689941 ttttatagca taaaagtact tccacatttt tggtgcaatg aactaattta gataataaca 690001 agatcaaaca gcgtcccttc cgcgtcaata aataattagg aactgtaatt gaacctctat 690061 tagtatattt ttttattgat tgcatgaaac atccgctcat tctgtcatgt ctcaaagaaa 690121 gctacaacag gatatcgata agcttttgaa gaaggtgaag gaaggtattg aagacttcga 690181 tgacatatac gaaaaatttc agtcaacaga cccctccaat tcttcgcata gagaaaaact 690241 ggaatctgac ttaaaaagag aaatcaagaa gctgcaaaaa catagggatc aaataaaaac 690301 atggctcagc aaagaagatg taaaggataa gcaaagtgtt ctgatgacta ataggaggtt 690361 gattgaaaat ggcatggaaa gatttaagtc cgtggagaag ctaatgaaga caaaacagtt 690421 ttcaaaggag gctttaacaa atccagatat aatcaaagac cctaaagaac tcaaaaaaag 690481 agatcaggtc ttatttattc acgattgttt agatgagcta caaaagcaat tggaacagta 690541 tgaggctcaa gaaaatgaag aacaaacaga aagacacgaa tttcacatcg ccaacctaga 690601 gaatatcttg aaaaaacttc agaataatga aatggaccca gagcccgtag aagaattcca 690661 agacgatata aagtactatg tagaaaataa cgatgatccc gatttcattg aatacgatac 690721 aatttatgag gacatgggtt gcgaaataca accttcatca agtaataatg aggctccaaa 690781 agaaggaaac aatcaaactt ctttatctag cattcgctca tcaaaaaaac aagaacgttc 690841 tccaaagaaa aaagctccgc agagggatgt ttctatatca gacagggcga cgactccaat 690901 cgcgccaggt gtagaatcag cctcgcaatc tatatcttct acgccaacac ctgtgtcaac 690961 tgatacgcca ttgcatacag tgaaagatga ttcaataaaa ttcgataatt ctacccttgg 691021 tacaccaact acacatgtgt ctatgaaaaa gaaggaatcg gaaaacgact cggagcaaca 691081 actaaatttc ccaccggata gaactgatga aattcgaaaa accatccagc acgatgtaga 691141 gacgaatgca gcttttcaaa atcccttatt caacgacgaa ttaaaatact ggttagactc 691201 gaaaaggtac ttaatgcaac ctcttcaaga aatgtcacca aagatggtat cgcaattaga 691261 atcttcgcta ttgaattgtc cagattctct agatgccgat tcgccatgtc tatacaccaa 691321 accattatct ttgcctcacc caacgtcaat cttttttccc aatgaaccaa ttcgatttgt 691381 ttatccgtac gatgtacctt taaatttaac gaataatgaa aatgatactg acaataagtt 691441 cggtaaagat agtaaagcaa aatctaagaa agatgatgat atctattcca gaacctcact 691501 agccagaata tttatgaaat ttgatcttga tactttattt ttcatattct atcattacca 691561 aggatcatat gaacagtttt tagctgctag agaacttttt aaaaatagaa actggctatt 691621 caacaaggta gatcgctgct ggtattataa agaaatcgaa aagttaccac caggaatggg 691681 caaatctgag gaggaatcat ggagatactt tgattataaa aaaagttggt tagcgagacg 691741 ttgcggtaac gacttcgtat ataatgaaga agatttcgaa aaactgtaaa cagtttcctt 691801 ttacttatat aattctcatc gtgatttact aggtaaatgt agtattcaaa atctccaatt 691861 tgtactcttt aacttcacct tcacatatta tctttttact cgatgtagac cgcaccatca 691921 ttacttgcta gcttataact ctttttttaa aaactgtttg gagaaatagg tgatttgttt 691981 gaagttgtac tcgaaatctt gtatgtcacc ataccaagga tcttcaataa tggtctgcac 692041 agtgccatca ttagtattcc aatcaccaaa aaggcaaact ttagctttag aaccttcagg 692101 ttgtattttt tttaggttat taatgttgga ttcatccata ccgattatat agtcatattc 692161 atcgaagtgt ttggtcttta tttgtttccc tttatgatta atcttgacgc catgttgctt 692221 acaaatggac actgtacgat gatcagggct ttcccccaca tgataattag aagtgccaaa 692281 tgaatcaatc ttgttgaatc gattttctag attagccttt tcgacttcat gtttgaaaat 692341 ggcttccgcc attggtgatc tacagaagtt acccaaacaa atgaatgcga ccgatatttt 692401 tggtttttca attgtcattt tcgtgttaac tttcccttct cagttttcta tcgcttatca 692461 aaaatcacag ggtttcaatt agccttttag gagttatatt ctttattggc tttatacttg 692521 aatggtgtga ttctctcgaa gggtttaaca ttcaagctcg gccatgtgct ggtacaagga 692581 aaaagaaaga aaaagtaatc attgaaattt ttctataata cgtacaccta taatataaga 692641 aggaaaagga ctgagtgttt ggaatattgt taaaagtttg aaactatttt tttgcttaat 692701 cgtttataaa aaaagttgta tttaagttgt ataaagtttt atttcatttt ttcacaaata 692761 atatcatatc aaatctgatg atctacgatc agaatttaga aagctttttt caaaggagaa 692821 attagcttgt cacccttata gaatgcaatg gtcttttgag ctctttcagc aacaccttct 692881 ggggtgaaac cgaagaactt gaagacttct ggtgccttac cggaggcacc aaatctgtca 692941 ataccgaagg attgatgagc gtatttgccc caacatgtgg tagccaaaac ttcaacagac 693001 atgattggaa cgttgtctgg taagactgat agtctgtatt ctaggggttg tttgtcaaaa 693061 gtgaagaaat ctggtagaga aacaacacga gccttgatgt tctttgcggc caaagtctta 693121 gcagcttcaa cactcaaaga cacttcggaa ccagtagcca ctaaaataat atctgggtta 693181 gcaacatctt gtagtacgta accaccctta gaagcgcttt caatagagct accttccaat 693241 tgtggcaagt tttgtctgga caaagcaatg atacttggag tatgcttgga ttctaaagag 693301 ttcttgtagg cggcagaaac ttcgttacca tcagctggtc tccaaacttg aatgtttggt 693361 agggatctga agtgtgctaa agtttcaata ggttgatgtg ttggaccatc ttcaccgaca 693421 ccgatagagt catgtgtagc aacccaaata actgggtggc cagacaaagc ggacaatcta 693481 acggcaccag cagcataaga aacgaagttc aagaaagtac caccgtatgg tttgtagttg 693541 gcaccgaaag ctgaaatacc gttcattatg gcacccatag cgtgttctct aataccgtac 693601 ctaatgtatc taccagagta gttacctgaa ccggaagaag gaggttggaa gtcaagggct 693661 tccttccatc tggtcaagtt agaaggtgtt aaatcggcag aaccaccaat caactctggc 693721 aattgattgt aaacatcctc aagaacagtt tctgataatt ttctagtggc cacggcagag 693781 tccttggcgg tgtaagttgg caacttagat tcccaatttg cgggtagttg gccgctcaat 693841 cttctagcca attcagcacc taattctggg aatttctttt ggtattcgct gaacaacttg 693901 ttccacttgt tgttggcttc gacacctggc tttaaaattg tcttttggta gtggtcgtaa 693961 acttcttgtg gaacaacaaa ggacttgtct gggttgaaac cgaatttgct ctttagttgt 694021 ttaacatcat ctgctttcaa tggggcaccg tgcacagagt gagagccggc atgcaaggaa 694081 ccgtaaccaa tggttgtggt cattttgatc aaagttggtt tgtccttgga taacttagct 694141 tgagcaatag ccttggcaat accggctaga tcttcgttac cattttctac gtacaaaact 694201 tcccaaccgt aggcttcgta tctcttagca acatcttcat cgaatgagat actggtagca 694261 ccatcgatag tgatcttgtt gtcatcgtag atggcaatca agttacccaa tttcaaatga 694321 ccagccaagg aggaagcttc tgaagaaata ccttcttgca aacaaccgtc acccaagaaa 694381 acataggtgt agttgtcaga caaggtaaag cccggcttgt tgtaagtggc agccaggtta 694441 gcttgagcca tggccatacc aacagcgttg gagatacctt gacctaatgg accggtagta 694501 acttcaacac ctggcaactc aaattcagga tgacctggtg ttctggaacc caactgtctg 694561 aactgtttca agtcttcaat agacagatcg taaccagtca aatgtagcat agaatacaac 694621 aaagcgaccg cgtgaccgtt agacaagaca aatctatctc tgttgatcca gtctgggttg 694681 gttgggttca tgcgcatttg actccataga acgtgtgcag ctggtgccat acccaatgga 694741 gcacctgggt gacctgagtt ggccttggat acggtgtcca cagccaaaat tcttatggtg 694801 gagacggcta gcttatcaat gtcagtgaat tgagtcattt tgtttgctaa agaggtaact 694861 atgtagagtt gcttgggatg agcttccttc tctgttgtac ttcagtttga tctgaaactt 694921 aaaaaacgaa atttaaaagg aagacaacgg tgagaacaag aaatgaatga atcaagaagt 694981 cacgatcaag tatgtaggta aaagatcagg ggggagtatg tacgtaacca aaaagattgg 695041 gaaagagttt atatatgaat catgcctacg atcgtacctt cttggctttc ccaagaaaat 695101 ttttcatctc tcgaacttct cgagagattg cgaacggaac ggcaaacgcc gccggcattt 695161 ctcggaaaga agactagaaa ataaatgacg gtgggaaaaa aagcaagaag ctacggttac 695221 ccgcagcggc actatagtag atgggctttt aagcccgttt tcagggtcag gtaatatgta 695281 atgtagtagc acttaaactt gctaaccata aatgaccaaa atgcaagttt gctgtatttt 695341 agtcccgttg gcgttttcgg atgcttcatt ccccagagaa gtgatgtgta tgcgaaaaat 695401 gtctcaatgc agctttggct gctgcggaac ttatccgctt tgtaagcaca tcttgtttta 695461 atgtgtatga atttttatat ttggttcgaa aattatgaca ttcggccaag aaactttcag 695521 aggagctgtg tattagcaga tggtaagcgc acgttgaaaa tgctgaatat tattaattta 695581 gacatacctt gatggctgaa cagtagtcag aaaattaaaa aaaaaaaaaa agcgcttatt 695641 acggcgtata cacgtaacta tatagacgta gatcattgaa tattgatatg atataatatt 695701 ttccccggga ttgcagaata ctgacacgcc ttttatttat cgttcatcgt gtatttcgaa 695761 cttgtcctca aacgggctct cagtgcgact gccctgggtg ctctcgcgta tcgattctgg 695821 aatttccaag tccagtataa aacttccttc ttcatcgtca tcttcgtcgt tattaccatg 695881 gcttgcctcg ctttttgcca tgtgtgaaag atcatccgcc tctgtctgtt cttcaatgac 695941 atccaagtcc tgaatctcct tatcactctc ttcctctgcg atttgaacca gtttaggttt 696001 agcacgaata gcagttatga ggttatcgtc tgcgtcctta ttgagtacct ggttatgctc 696061 gtcatcttcg tcatccagac catccaagat ggaagaacct aaggttatat gtgacctgat 696121 atcaccagct gcattttgtc tcttagagct cgagcgtagt tttgattgca gtttgtcggt 696181 actcaaaccg cttgtcacac caggaatgta ggcaataggc aaaatattag aagcccttgt 696241 acgagtggta gatgctgaac ttctgtttcc cggcacgttg agagttggag gtaccagtga 696301 cgtattgaac agggtgtgac tttcatcttt tctcataccg ccatcatcct catcgtcttc 696361 atcatcatcg tcttcatcgt cgaagtattc ctcttcattc ccgtaacttt gcgatgcctc 696421 ttccaatttc aaagctttat ttttttgcct tttgggcttc caatatctct tgttgatgaa 696481 atacaacgcc accaaggcaa taagcatcgc accacctaca atacccacgg tgaaccccac 696541 aatcaacgag gttttctcat ttgaattact ggaactagaa ctagaggagg aggaagataa 696601 actactcagt tgtgaatcgg actgtttcgc acagtatgtg gatgggcact tgtcacatgt 696661 taatgaagtc ataacacaat attctcctga agcgcaaaca gggcatgatg cagttgaatc 696721 gcaaacaaca catccgtcgc tgcctctagt tgcagaagtt gaagaggtgg ctgtgcttga 696781 caaggatgaa cttgcagaag ccttggagga gctcgacatt ttttgtttga ttttcagaaa 696841 acgaacgtaa ccagtttgat aaatgtggtg cctctcttat tcggcctggg aagcagtgca 696901 acaatagcgc acattataat catttgattt taaattcacc ccaggacaat ggggcattat 696961 tttctgttga gagggtaacg cgttgtttat tgagaactta acgcgtttcg atttcaagaa 697021 tgcactatag tgcggaaatg taaacagaat ttattgatac ttggcattat ttgaatttta 697081 tttatatctt gcccgaacat gtcttgacac aagcaaggaa cgtttgctca ttaacctttt 697141 acacggttat gcttgtacca aaggctgatc acctggttcg ggcacaaaac agagtttagt 697201 ttccaactgt gtttcctttc ccggatcaga tgatggtaag ggaacggtaa cggcgtcttc 697261 atctttacaa ggttggccct tcttaagatt ttgatgcttt gtagtccatt ttttgaatct 697321 tccttgcaaa agataaattt cccttcccaa attatttcta agtgtgtccc acactcgtgg 697381 cacgttttct tgatttttgt cgccaaaatt agcactctta tggaaaatac ggaacatacc 697441 accgctgtta tttttagaac tactcttttc agagccgagc atatcaagag aagtcctgac 697501 atatcggtat ttcaaaagag tctttttatt ctcttgcaaa ggaggcccgc taataatgct 697561 ttccgtatca tcagttacta gctccttttt gatatttttc ccaaatgtgg gacttatgga 697621 ggtcttctca ggttcagaag cggagtgaat ttggcaggtt tcatcaattt taactaatgt 697681 atcgtcattt tcaaaatcgt caggtgttaa gggtgatata atattcaatc cattcataaa 697741 atcatcaata tcactaaaat atggtgtctt gccccgttcc atcaagtcct ctccatatcc 697801 atatacttta tcatcgttta cctcttccag attattatca gatggtaggg ctaatttact 697861 cttatttttt ctaaaccact tattcaacct ctgtctccaa tcacgatcat agcggccatg 697921 caattgagaa agactcttca gctgcgtatt tgaactgctt tcactgtcag aaaaattctt 697981 attggtttta aaccagccag aacaagatcg gaaaaaagta tcactttcag taacttcttt 698041 aatcactttt tccagcctgg caatttcttg gtcagtttta tcgtgaatat gatcaactct 698101 gacacctaat tgtgcagtct cattgattaa ccttcgtaaa tcttcgcttt cagtcaaatg 698161 cgttgttatt tcagcttctt cgtcaaactg gaaggttcgt tcatcatcag acctaagctc 698221 tgaggggctt aatactgttg gtaagactcc agaaatcgtt tgcatgattg atattttatc 698281 tttttatatg attttgtttt ttagttatac ttacgcttgc tacccttact tatgaagtca 698341 gtctcttttg ttagctttta ttacaacact tatgagaaat ttataaaaaa atcccaggaa 698401 tgctttcaca aattatccat tctacataaa atcttttttt atagtattac ttttttgtga 698461 catcaaaatg aagcactaaa taattataga aaatattcag caaaaaaaaa gaaaaacctt 698521 cttctgaaaa aaaaaaaaaa aaattcaaaa aaagacacct ttctaccttg gcagtaaatt 698581 tcaaattaat tatttaccaa actgtagttc ccgctcacta atcctttctt atacttattc 698641 acattactgt cactttgcgg ctgtatttgg ccgcgtttcc ctttcgggtg caggtacaag 698701 aggtatccga aacaagaagg gttaagtttt gaagaaaatg ccaagtattt caatttcaat 698761 aataagaacg caaaactaca ggagactctt actaagcata ctacttctca aaaaagggct 698821 ttattttata gaacataaaa catactgtag gatcgcacac tggaaaatat gttgaaacga 698881 tcatctctaa tatatctatc atgtgtccta atcattacca taccaatact tttgcatgta 698941 tacaatggtc caggactgtc ccatgaagcc aatgaacata gggcttctca caagcaaaaa 699001 agaacgttag caaatccgga taaacccaaa agcgaaaacg atgaagatct attttgtgcg 699061 gtaaccaacc cagtcaccgg atcatacata gatctatcac agctatcttc aactcccaac 699121 aaattaaggg agggccaaaa acagatttct ggcaataaca agcatgaatc ctccaagacg 699181 aagtggtcag tgagaggttg gggctacgat acaaacttca cgttaggcat ctgctctagt 699241 cctgtcggag aagctgagtc gcaacaactg tccaatctaa cgggcgcttt ttacgtagac 699301 cagttgaacg aaaataattt agtatcgatt ggagacttca gtacaaggcc tgcgttagtc 699361 ggcggctcta ctgccaagaa attaactctc aaatacgaaa acggctctat gtgcccgaac 699421 gggaaggaca agaaggcaac tttattgaat tttgtctgcg ataaagaaat tcaatcaaag 699481 gcccagatat catacattgg aaacctacac aattgctcgt atttcttcga agtccgcagc 699541 attcatgcgt gccccacctc aaacaaaaag aatgaagtta acgttttggg tatcttcatc 699601 ggtatcttcg ctatattctt tttagtcgaa tttgcgggga gaagatggat ctatgctaaa 699661 ctaaataggc atttgaaaaa cgacgacgag ttacacgaca tatcgccatc tttaaatgag 699721 caaccacact gggacctcat agaggacggg tctcgctgga gtaaattttt caacgggata 699781 attaagacga caagaaggtt cacgaaatct ttaatgaggt ctttagtcag aggcaggaac 699841 agccgtcaag ggggcataag actacggtca tccccatctg cctcttcgtc cagccttgcc 699901 aacagggagt tcttcagaga catggaggct caaaacgaaa ttattgacag cctagacatc 699961 aatagtcata caacagaaag cgaccaccca actttggctg ataatagcgt ataaacaatg 700021 catactttgt acgttcaaaa tacaatgcag tagatatatt tatgcatatt acatataata 700081 catatcacat aggaagcaac aggcgcgttg gacttttaat tttcgaggac cgcgaatcct 700141 tacatcacac ccaatccccc acaagtgatc ccccacacac catagcttca aaatgtttct 700201 actccttttt tactcttcca gattttctcg gactccgcgc atcgccgtac cacttcaaaa 700261 cacccaagca cagcatacta aatttcccct ctttcttcct ctagggtgtc gttaattacc 700321 cgtactaaag gtttggaaaa gaaaaaagag accgcctcgt ttctttttct tcgtcgaaaa 700381 aggcaataaa aatttttatc acgtttcttt ttcttgaaaa tttttttttt tgattttttt 700441 ctctttcgat gacctcccat tgatatttaa gttaataaac ggtcttcaat ttctcaagtt 700501 tcagtttcat ttttcttgtt ctattacaac tttttttact tcttgctcat tagaaagaaa 700561 gcatagcaat ctaatctaag ttttaattac aaaatgggta aagagaagtc tcacattaac 700621 gttgtcgtta tcggtcatgt cgattctggt aagtctacca ctaccggtca tttgatttac 700681 aagtgtggtg gtattgacaa gagaaccatc gaaaagttcg aaaaggaagc cgctgaatta 700741 ggtaagggtt ctttcaagta cgcttgggtt ttggacaagt taaaggctga aagagaaaga 700801 ggtatcacta tcgatattgc tttgtggaag ttcgaaactc caaagtacca agttaccgtt 700861 attgatgctc caggtcacag agatttcatc aagaacatga ttactggtac ttctcaagct 700921 gactgtgcta tcttgattat tgctggtggt gtcggtgaat tcgaagccgg tatctctaag 700981 gatggtcaaa ccagagaaca cgctttgttg gctttcacct tgggtgttag acaattgatt 701041 gttgctgtca acaagatgga ctccgtcaaa tgggacgaat ccagattcca agaaattgtc 701101 aaggaaacct ccaactttat caagaaggtt ggttacaacc caaagactgt tccattcgtc 701161 ccaatctctg gttggaacgg tgacaacatg attgaagcta ccaccaacgc tccatggtac 701221 aagggttggg aaaaggaaac caaggccggt gtcgtcaagg gtaagacttt gttggaagcc 701281 attgacgcca ttgaacaacc atctagacca actgacaagc cattgagatt gccattgcaa 701341 gatgtttaca agattggtgg tattggtact gtgccagtcg gtagagttga aaccggtgtc 701401 atcaagccag gtatggttgt tacttttgcc ccagctggtg ttaccactga agtcaagtcc 701461 gttgaaatgc atcacgaaca attggaacaa ggtgttccag gtgacaacgt tggtttcaac 701521 gtcaagaacg tttccgttaa ggaaatcaga agaggtaacg tctgtggtga cgctaagaac 701581 gatccaccaa agggttgcgc ttctttcaac gctaccgtca ttgttttgaa ccatccaggt 701641 caaatctctg ctggttactc tccagttttg gattgtcaca ctgctcacat tgcttgtaga 701701 ttcgacgaat tgttggaaaa gaacgacaga agatctggta agaagttgga agaccatcca 701761 aagttcttga agtccggtga cgctgctttg gtcaagttcg ttccatctaa gccaatgtgt 701821 gttgaagctt tcagtgaata cccaccatta ggtagattcg ctgtcagaga catgagacaa 701881 actgtcgctg tcggtgttat caagtctgtt gacaagactg aaaaggccgc taaggttacc 701941 aaggctgctc aaaaggctgc taagaaataa ggagattgat aagacttttc tagttgcata 702001 tcttttatat ttaaatctta tctattagtt aattttttgt aatttatcct tatatatagt 702061 ctggttattc taaaatatca tttcagtatc taaaaattcc cctctttttt cagttatatc 702121 ttaacaggcg acagtccaaa tgttgattta tcccagtccg attcatcagg gttgtgaagc 702181 attttgtcaa tggtcgaaat cacatcagta atagtgcctc ttacttgcct catagaattt 702241 ctttctctta acgtcaccgt ttggtctttt atagtttcga aatctatggt gataccaaat 702301 ggtgttccca attcatcgtt acgggcgtat tttttaccaa ttgaagtatt ggaatcgtca 702361 attttaaagt atatctctct tttacgtaaa gcctgcgaga tcctcttaag tatagcgggg 702421 aagccatcgt tattcgatat tgtcgtaaca aatactttga tcggcgctat ctgtaatgga 702481 aaagagaaga agcctcttga ctcactatcc actcgaactt ggaaacaatg gtcgaagatg 702541 cagtatatga tacgacctaa accgaacgag ggctcaatga cattaggaat gtactctcgt 702601 atatgttgca aagttgtctt cattttgata gtaaccaaac tgctatctag ttttacgatc 702661 tggccattta cttgacaggt aaattcaccg ttcttttcca gttcttcatg cctcctaatc 702721 aattcatcct gggaaaattt tgacaaaaca gattcgatta attttgcttt ctgtttgaac 702781 ttcgatccga aaaatttctt attcacttcc acaacccact cggttctttc ttttggtgta 702841 tctagctttt gctttaccgt cagacttctt cccgttttct tggagtgtac agttaaatca 702901 aaagccgccc tgtcagcaca accgacacat tcaatccaac catacgatgt taaaatttca 702961 ccgtcccaac aatctgtggc atagtgtgcc atttcattct tcaaatgctg gcgaaatctg 703021 aatttgtcct tgttgatccc aatattcaac aaaaattgat gaactcttgc cataaaatat 703081 cccaatgttt cattttctac cattccagaa ttcactgcct ctcctatagt cattttcaca 703141 ggcagttgga cttcaccact ttcctgtaat ctgcgtgata gtagtggaat ctcctcattt 703201 aacacttcat tgaattttgc atgtgactta ttcaacggat caacaaagtg ctcaatttct 703261 gccattaaaa actctcttac ccttaaaagc ccacttctgg gggaaatttc gtttctgaat 703321 gacttaccaa tggaagctga agcaaacgga attttccctt ggttgatttc caataatttg 703381 ttgaaattga gaaattgtcc ttgtgcagtc tctggcctta gaaaggcctt caattgtcct 703441 gaggctccaa ttttagtttc gaacatcaaa ttaaaggaag ttagtgcgtc taaaacatcg 703501 ttagtgactg gatcattaat gttatattcc tgcatgacga gattcaactc aggacccgaa 703561 aacccgtcaa tcgtggtcaa tattttctcc atatttttca tatcctgtgg attgacatcc 703621 ttgtccaaca gccgtttttt caacgtctgt tcaatcaaat ggtctgctct gtagtattcc 703681 ccagtcttag gatttcggca catccaatca gtaaatttgt ctacatgccc agaagtcttc 703741 aacacatcgt aaggagttag cattggccca tcaacctgaa gcatgttttc ttccataata 703801 aaatgttctc gccacagtcg aatcaagtta ttttgcaact gacaacccgg aggccctaaa 703861 tcaaataaac ctgacacacc accatatatc tcaaacgagg gtgtgtagaa aaaccttctc 703921 ctcaatgtac tttccaattt atctctttcc gaattggaca ttaacggcat gttgatgtga 703981 tatgtctttc aacagtccaa caaaatgttc tttaatgtat cacatttatc gtttttcact 704041 ttcattgtct aaaagaaaaa aagggttgca actactatcg caggttcata aattagacct 704101 catacgaaca gttcatcaga actgatcaat atgcttcgac cttttatatt ctgtcaaggt 704161 tattcattac ttactcactg aattgttaag acatcgtgcg cctagcctac atagttatta 704221 tgaattatga aacacgctta tgattataat cgtatggaga gaccaccagc cctttgttct 704281 tcctggcacc tctgaatata gtttctaata tgtcaatcat ttcttgtttg tcgtctacaa 704341 taaagttcaa cttgttgttg ttccctgtac caaaatcaca catcatgtgc ttattgtggt 704401 agaaaaacat tactgtcatg ggatccgtca gctcgtacat ctcatcaaaa tctgaaactt 704461 catctatatc acataaataa ataactgcaa agttccttac tctttcagca atcgaagata 704521 acaactcgtc catgatcata cattgtctat catttttgcg accaaaacga atgacaacaa 704581 gtcgtttagt ctcggtaaca atagcctgat ccacatgcca tcccgtacgc aattgaggca 704641 acaaaacact agccatcaaa acttgacttc ttactctttc tctacgtact atttctatcc 704701 gatgatcgaa tttggtatgt aagttctgtt tttccacttt gcgaagcggt cattggccca 704761 aaagaaatac aacgagtcat ctcctcgcag taaactgtac aacagcaaag aaacagttaa 704821 aaaccctcca gagagaacac ttactactat agcatggatg aaaacggtac agtaaagcct 704881 ggctatgaat taaagggact caattcggga aattcgaggt caaatatgga taaggatccc 704941 atcgttagca aatttcatag ggctggtctc aatgattctg cagacgagga agatactgat 705001 atcaatggta atcgcaacac tagctggata acttcaatga ttagtgaaga aaaacgcaag 705061 gtggagggaa aatctatgct gaatgatgag gaagatttgc atttatccaa agctactttg 705121 aacaaatgcg atgctctagt taagatatta gcggatatta tcaagctaga gtttgttatt 705181 caccaatcat ggtatatcag atcccttcac aagagtgtct taattcaatt tgaagtagaa 705241 acgtctggtg gaaataagaa tagcgccggt gatagcggcg acgatgatga tgataatcat 705301 aatggtaatc tggacgatag cttttataaa gatttaagct taaaatgcat caaaaaatgc 705361 gagaagtctt cccttgcact tgagtcgctg tcaagggaca ttgaccaaat tagagatttc 705421 ataatgtcca atacaataga agacaacagg gttgacaggc ttttgcagaa ttcgatgacc 705481 ctgttattag agtgttggat ctactctatg aagagattgc gccgtctaag gatgaagatt 705541 gcaggtatct ttgttaggtc caaacttttg cttattgatc atgaattagt gaccatatgg 705601 cattttttac aggagcaaaa cgagcacgaa acggttaata atgagaacga actgaaattg 705661 gcagaaacaa taaaatcata cagagcgttc attaagatat ttattcaaca attggaggac 705721 tccgaatcgg gatctccatc ctcctctttg tttgaagaat gtttacacgt ttttttggat 705781 atagaatcga tgtacaactc tttaaacctg aattggcttt tgaacgaaaa caaagcatta 705841 caagaaagac tactatcacc atcgtcgaca tcggagaacg atcatactaa taaccttccc 705901 gttattgatg agacaaagga aatcgaagat atcagctcat ttgtcaatag cattgtggat 705961 gcatccatgt tgacacatga tttgactcct attaactcat cagatagcga caatttatca 706021 aacggagaaa tcgatcgtct agatggaaga aggttatcct cttccacgtc agatatgtca 706081 ttgatgatgc aaaggacttc tctgcagaaa caacttccta gcttattaac tgccttcaac 706141 aacgcaagaa gactagaaca agaattgcaa aacgcatgca aagtaaacga taacaaacat 706201 agcacgaaag atactgattc aaatatacga cggaatgaac atgctatgtc ttcaagtgta 706261 tcctccatca tctcccaaaa ctccacatta gcatcaccgt ctcctccgat gtcatcgtcc 706321 tttatatcca cggcgccatc acaatcaagt tctcgtatga gtacattacc actgtctcct 706381 tcctcttcat tattggaatc acaatcgcaa acgctgaaga acaatatgtc gcaatggttg 706441 aaccaatcgc gatctggcct caacggcaca aaacttattc caacaaacca cattgggttt 706501 cacagcaatg ttctgaatac tttgtatggt atcggtggtg gtccggtatc gaaatcttat 706561 aaatccaatc aaccttcttc acaaaatact tgataagaat aaggatatca ttgctatgta 706621 aacaaactaa atgcgagggt tgagtacata aatacaaagc aagactttta tcatacataa 706681 cacatataac aaccaatgca tgcatcctct cgacaatagt tttgtgcgta tgtctttgcg 706741 aagtccaaat actactcaca tccatctttt attttttaat cccatcgcag cgagtttaag 706801 cctgaaaaat agtgaaccag ttgaaaaaca ctaataacat cgatgcaaaa ctaactatca 706861 ataaactgtt gtgtttttag aactctgtac gttgtttcct atcccaagag ttcaataaga 706921 cgcagccaag cttttattct cttgactcgt ccatcataga gctttataga aatgtcagag 706981 aaggcttctg aagagagacc catacggctg gccgttctgg ggggcacttc taccggaaag 707041 acctccctgg tatctaggct tactgttaat atcgtccacg aggttcatta tccaacaaga 707101 aaccaaacta actggctttt cggctttgtt ccgtcatcga tcctggccag agctatatta 707161 gacgaacaag ctcacgaaag actttgcctt cgttccccaa gcagccaaac cttagagcct 707221 atcttccctt cacctcaggt ctccaaaaat gtactgctgt cgccattggt gtttcaagct 707281 tccactgata attttcaatc agtgaggtta cacaacaaaa gccactccag gagatcccta 707341 tctttggata aatctgattc tccgctgtat caaacttttt ccaatgacat taactctcaa 707401 agtgttccta aaatcaaggc agaccagctt aacgttatcg agcattttaa attgcccctg 707461 aattacattc cacccactta tgcaccaatc cagattgata ttattgatac gcctggcttc 707521 agtcctgata atgtggtgcc gttcttagaa gtttctctct tccgaaattt aggaaaatca 707581 atcctacatg gactagcaga tgaaccaaga cgacctgtat ctactacttc actattggtt 707641 gcctctggtg cctctgagtt gaatggtaaa gttgacggtt atatcttggt gtatagcgca 707701 gtccctgaat taaaccatat tggaggccct ccggaatatg gagatgatgt gatgaacaca 707761 gatacggaaa acgtcagcga tggtggattt gaacttttaa aagtgattag aaactgcata 707821 ctagatgctt ggactgaatt tcgaaattat gaaaaaagat gggaggaagg caaagaggat 707881 gatatttact cattggttta cagcctgaga catctatgga gtaaaaatag caaagagaaa 707941 agcgccaaaa tagagcaatt gagatcctat aataccaaac taaaatccat cgagttagac 708001 ccctcatctc ccgattcacc accaccatgc attatcgtct gttctcacgt taatcatgaa 708061 ctcgcaagcc caatgttgat tgaaatggga agacaactag caacaaaatg gaaatatgga 708121 tttgttggaa tagacagcat ggatgattta aatgtcgatg tggcggttag cttactaata 708181 aaggaaatat cagaaaagat gaagctactg gtttctaatt ccaatggaag tagtagtagt 708241 ggtaattcaa gttcaattta caactctcat ttaatgaatg acaagaagaa aaacaacaat 708301 gccggcttaa acaaaaatat gttgaagaaa attataaaat aattgataga gggaagaact 708361 ccctttaaca ttcttatgac catgatacat cgcacttttt tttacttgga ttgaggaaat 708421 atgtatatat aggcacgtat gtatatatac aaatgttctt tctgaaacca tgtaaacaga 708481 aaaggaaaaa aaataattat attttattga gctttatggt accatcttca tatccaatta 708541 aacaccagtt acatttcgcc agcgctttaa tacgtctaag ttgtcctaac ctcaacccat 708601 ctgactgcac atcaaacgat tccaaacatg tcatggctcc cactttatag ttatgggatt 708661 tcgagctgga ttcggtattt gagccgctac cgtttgttag gtctcccata gagctatcac 708721 tcacgaccag gttgttcttt gatttcacaa aagtttgctc cacttctgaa gtccgcatat 708781 tataaacaat ggtcatacct gaccaactac tcacgactaa gtaatcgtct tttactttat 708841 caatatgacc aatattcttc aagggaagat gtacttttga tggctcactg actctcagtg 708901 agcttgggca ttttatcaaa agcgcatcat ctctaaggta tttcgtctca agttgtaagt 708961 tcactggaat tttgtacttg gttatgaaat cgtctgttga acaactataa agttcatccc 709021 cgctaacaca catatcaagt attggattcg gataatgatc gttagaaaca tggaccagtt 709081 ctgcaatgtc cctttgaagg ccttcatcaa aagtaatttt aaatccgact acaaacccat 709141 tttcataacc taaaaatatg acatcgttta atttagcaaa tctcattatg ataccgaatt 709201 tggagtcttt cgaaattcct aaaaaattct gctgcttcaa gaatctgggg aaattaatat 709261 tattgaatgg tcttttcaat ttaaatgtgg agtcttctat tatctgatat atatcgatag 709321 tttccgaatc atcagtatga cagcaaacca atctataact tttattatct ttggttggtt 709381 tcacttcagc ttcgatgatg aaattcgcaa aattcagtgt gtttatgggc atttcataga 709441 ttttagtcca ttgtaaatga tccgttttat tggcttggct aagctttcta actaaatcta 709501 tagatagttg tgtagatgaa tcaagctcaa aaattcgcag catggagtct ttcgaaagaa 709561 tgtacagcac attggtagtt tccacccacc aaaacgctat aatgtgcgag ttgccctcga 709621 tttctatatg tgtaatcggt ctcttggtca ccaggtccca cataacgaaa taaccgtagt 709681 tatcaccgga taacaagact ggcacattcg aaactgacgg tgctttgatg acctgcaaag 709741 ctgtgatgcc ccttttatgg taacgtaagg tgaaatcgga taaagtcaac gttctcttca 709801 ggattatctc attactaaag cctctcatgt gttctacgcc cattgtaatc gacgctcgcc 709861 ttgactgcac atcacaccca atttatgcac gtgcttaaat agtagtttat agcttagtat 709921 ctctgtattt ctgtcttact catcaccgtt tcgtctcaat atttgcttaa aaatcgaaaa 709981 attttgttat aaatttagtt aaaaaaaagt gaagagaata atcatcactt ataaagacaa 710041 cttaatagac gctggtgtgg acgatccagt gatagagaag gggagaagta gatacgcaga 710101 atgatgacta gggagagcat agataaaaga gcaggaagaa ggggtcctaa tctgaatatt 710161 gtgctgacgt gtccggagtg caaagtctac ccaccaaaaa tcgttgaaag atttagtgaa 710221 ggggatgttg tatgtgctct atgtggtcta gtactatcag ataaactggt tgacaccagg 710281 tcggagtgga gaacgttttc aaatgatgat cacaacggtg atgacccaag tcgtgttggt 710341 gaggcttcaa atcctctttt agatgggaat aacctatcta caaggatcgg aaagggtgaa 710401 accacggata tgagattcac caaagaactg aataaggcac aaggaaaaaa tgtgatggat 710461 aaaaaggata atgaagtaca agctgcattt gctaagatta ccatgctatg tgatgctgct 710521 gaattaccga agattgtgaa agattgtgcc aaggaagcat ataaactttg ccacgatgaa 710581 aaaactttga aggggaaatc aatggagagt ataatggctg catccatact gattggttgc 710641 agacgtgctg aagtggcaag gacttttaaa gaaatccagt cattaatcca tgtcaaaact 710701 aaagagtttg gtaaaacttt aaacataatg aagaacattt taagaggcaa gagcgaagat 710761 ggtttcttga agattgatac cgataatatg agtggtgcac aaaacctaac ttatataccc 710821 aggttttgtt cgcatctggg cttaccgatg caagtcacta cttctgctga atataccgca 710881 aagaaatgta aagagatcaa agaaattgca ggtaaatccc ctattactat cgctgttgtt 710941 tccatctatc taaacatcct gctctttcag atccctatta ccgcagcgaa agtgggccaa 711001 accttgcaag ttactgaagg taccatcaaa tctggttaca agatacttta tgagcataga 711061 gacaagcttg tggatccgca gcttattgct aatggtgtag tgtctttgga taacttaccg 711121 ggcgttgaaa agaaataatg aagtgataaa acagtaaatt ataggaacaa gaagcacggg 711181 tactcgtgtt agagggtaga accttttcca tggcagttca atcgaatatt tattttgtta 711241 ttttacaatt caaaaaaata gaatgaacac tttataattt aacaagattt ttcttttttt 711301 ttttattgaa ggaggtattc gaaaggatga aagctaaaca agttatttga aatatgcata 711361 catacatata tatatatact gtgtatattc aaatggtggc ctttagccca taccgaattg 711421 ttttgccatt tgttgcattt gtggatcttg catcattttc atcatttcgt tcatatcagg 711481 cattcctccg cccattcctc cgcccattcc gccaccaaac atgttcatca tattttgcat 711541 tagacctgga ttttgcttca gcttttgttg tgcctgctgc atcatttgtg gagtcacttt 711601 tggcatacca ggcatattcg gcataccagg catgtttggc atacccggca tgtttggcat 711661 gccaggcatc ctagcattgg caccaggggc tcctggttgt tgctgggttg cggtttgtgc 711721 cattcttgcc atcatctgct gttgcatcaa tatcatttct acctcgaaca cagaagtacc 711781 tgaaccttta gctacacgaa ccattcttgt aggctcttca atgaacattc taccatcaga 711841 ttctagttct tctttagtca tagaatccaa aacgtaaacc attttcttca tcttttgaga 711901 ggtttcctcc tcccctactt gattcatcat attactcata ccaggaatca tctgcgctat 711961 atttgataat ggacccattt tcattattgt ttgcatctgt ttcttgaaat ctagcaaggt 712021 gaacttaccc ttttggatgt tttccattgt ggcttttgca tcttccttgt tggaaacggt 712081 ttgtaattgc tcaaagagac tctctatatc accaataccc aacagtttag atatgaatga 712141 cttaggcgag aacttttcca aatcatgaat gtgctcacct gtaccaataa agataatcgg 712201 agtgtttgtg gctgcaacgg ccgaaattgc cccaccccct ctagcgtggc cgtccatctt 712261 ggttaatata atggcaccaa aatcggacga ttctttgaaa gccttggatt gttgctctgc 712321 agcttgacca atggaagcat ctaaaaccat gatagtttga ttaggcttga tgacattgga 712381 tatttcaatc atttcttgga acaactcttc ttcttgatga tgcctacctg aagtatcaac 712441 gatgatgata tcaaacttct ctttcttaaa cttgttaata ccttcttctg caactttggc 712501 agggtcagtc tccgtatatg acccataaaa tggaattctt gctcttatag cgttttgttt 712561 caattggtca aatgcaccag cacggaaagt atccgcacat accaaaccca ctttgaaacc 712621 tctcttcgag tagtaaactg ctaacttggt acaggaagta gttttacctg aaccttgcag 712681 cccaacaaac atgatgatgt ttgtctttct cttcttgggc acaaaggcct tctcttcact 712741 accttcgcag gtgaccaact tacacagttc atcaaacacc gttttctgaa taagcttctt 712801 agtttgtgcg tttgttgtgg acttctcact acggttctca ctcagcagct gtgaccttat 712861 attatttcgt aacttagaaa ccagggcaat attcacatcc gattctaaca acgcagtcac 712921 gatgcccttt aacattacat ctacggatgt agtaaagtca tcctgtgtat tggaaatcgc 712981 gttattcaca gcagaattaa tccgcttccc caaatcagcc aaaaccatcc tttagttaga 713041 ctcgatgctg tgttttcttt cccttctctt ctgcatcctt gctgttcaac cacttttcat 713101 tatcttgttt taccactatt ttttttcact ttgttgatgt ctttatcgtt agcggtgatt 713161 tttcgatatt gagatgaacg aaaagaccat catactataa caatatgggt agtgactgaa 713221 gtataggaga gccgcaattg ccggtctaca gaactcacaa ggcattcgtg aacaatgaac 713281 agtgtttggg atgatgctag aatagaggac agaacggtgg acaaaccagt aggctcctct 713341 cacgctcagg agaaactcgc gctggtaaaa tcaactttgt ttaaacttga ccaagaagat 713401 agaccagaat gcgattcctg ggtacaacta gtcaaattga tctgcgacga agaccgtgaa 713461 gaagaattta ctacattcaa ggagttatta agggaagtca aaaacgttaa tgataaatcc 713521 gtcacaggcg ttgccttgat tcattatatc attgtatttg atcgtgcaga ctacattgag 713581 ttactacatg ataatccttc tggtgcaaaa ttagatttga atcttgtcga cgacattgta 713641 ggttacacac ctttgatgtg gagtttcagt ctgcagagaa ggaactgttg cttggagctg 713701 ttcaacgcat tcgacgagat aaacttcaac atgacgaata aggctggatt aaccgcttgg 713761 gatatggttc ctccatattc accactttcg gaatttttgg aacaaaacaa tatgtttcga 713821 taccgtaccg aagtaaaaca tgaaatacct caaatttccc aaccgaaaga cacctctctt 713881 ctaatgagta atgaagactc taccacgaaa gaaacttttg ataatattga cttacaagtc 713941 gccggtttga ccctgtcccc tggtgcaaat gacaacatgt ttctggattc tgatgaaaag 714001 aacatgaatc attctcaggg agctgcaacc ctaatagatc ccacatatac agaagactac 714061 cacggtacat ttgattatga taaactatct ccggaccaat acttggaatt ttccgacttt 714121 gatataccac aaatcctgaa tctattgata tcgctaccac aaaaggaacc tcacatgacc 714181 acctatccag ctggtttaat ataccaatgt attagatatg ctgatcataa gataaagtcc 714241 aagccactag tagaatcgtt aattaactta tctctaacaa aaattctgac cagtgtttca 714301 tccaacggag ctgcaggatt ggtctccaca gaagcttctt tgcaagcagg tgacattgta 714361 ttgcaatcgt attggttaag ttgtttatct tttctctatt actacctctg tagagatgat 714421 tcatttttca agaggcatcc aagcgtgtta caagagctga ttaacaccat ccactctatt 714481 atcatagaac tgacatcttc cattcattgc aggttgattt ctttgataga ttcaacttta 714541 ctagcataca caacaatcca ggacgttaaa caaactttat acaaaagaga ctggaacttt 714601 tttaaaaaga gaaagcaggc caagctttta ttgaaggaaa agaacagaaa acaattaaag 714661 gaacaacaaa agaaagaact tcatcgaaaa agccagggtc aagaaaatca tgaagaagag 714721 gagggtcaac aagatgggaa tgattcagat gatagggcat caacaaatga tgataacaat 714781 tctagtgttt cactctttta tgataaagaa attttgagac atttatatcc tccatcattc 714841 gaagagcaga tgaaaccctc tccactaaag attgttcaaa tatttggtgc cttgtcttac 714901 gttcttaatt tacatcaaac gcatccgatt ttccaacaac agtgtctctc tatttcagtt 714961 aactggtttg ccacgacctt attcaataag atcttaaagg acaaaaagaa aagatcttta 715021 tcaagagccc atgctattca aatcaggtta aatctttcaa ctctagaatc atggatacag 715081 aacaacgatt tctgtgttcc taaaccgatg cttattgatg acttcatgtg gcagcgcttt 715141 ccaatgactt taattcgcga cgttggcgag atagatttat cggatccgat actaagaaat 715201 gtagcaactt acaaacctat agatgaaaat aacaaggact tgatatatga tacgtcaaac 715261 tcattatttt actaccaacc tttccataag atcgcccaaa ttcatcttga gccagttttc 715321 caactattac aatggttgca agtagctaca acactagata gtgaagaatc attaatatca 715381 acaatgaatt tattaccaag aattacacca gtacagctcc taaagtctat ggaaaaatac 715441 aattacgaat tgaatgaaaa taaattcaac tccaaactga agaaattttt aaacaacaaa 715501 atcaaagata gtaagatgag caaggcagac gcgtatttac aagaacatga aataccgtat 715561 ctagttttac caactatacc cgaaatgaca gacttgtatt caaagggtcc tgattcacat 715621 tctttccaac cgtttttacc aggcagtatc caagacgatg tttatgaaat tcacgatgtc 715681 aacttcaaac aaagacaaaa tgaaccacag atatctcgga ctaactcggg tacctcagat 715741 tttactggag atgaggataa ggcgcaatat gaaactgaag gggtagggga aagtatagat 715801 attaacgaaa cagtcgaacc cgagagcaac gcgttcaatg taggtaatga tgattatttt 715861 aaagaattaa atattccgtc ttcaactgct caacgtcctg cttggtcgaa taatgatgat 715921 atggaacaaa atccgtggta atttgtgcgt tagaacagtg aacttttgta tcgaacttta 715981 tataataatt ctacggatgt atccatctta tttcttttca aaagaatgga agaatagaaa 716041 tgtaaataat gagttaaaag gggcagttgc ttgatatttt gacacgaatt tagttacaac 716101 attttgcata tagcttcaag tgatatttat ttatttttaa tatagtaccg tggactcaca 716161 gtttgggctc tcgctgttct tcaaattcta aatcttgctt gaaaaagccg tcattaaaac 716221 gattctgaga ggtcttctta acaaaagctt gagagctttc aagttttgaa gctttcacat 716281 ggggatcacc atttttgagc gaattctgag aatcatttga ggatacagaa aactttctat 716341 tttctttgtt cgcaaacatc tttgaagcat tcatatttga agccgacggt ggaactggaa 716401 aattctcagt gtctttttcc ttcctgcctt ctagttttgg agatagtgta tttaacggtt 716461 gtgaaggcct tcttggtact ggtctcctat tagaaatcat ttttggattg gatgtaagga 716521 taggattatc tgattctctc tcatctgctg aatcgtcatt tttcttatct tgaacatcta 716581 tttcatccat atcttcggtg tcactcgaat taccaacatt atccttatac catctaccga 716641 ttttcttgat tgaattcttg aagtatttcc ttgacttggt agaattttca gaactggaaa 716701 catcatcatt agtcgcggtt gtgactgttg tctgggttgt agttttcgtt gccactccag 716761 atgcgtcaac aagatctttt aggttttctt tctttctctc tggccttaag gcttttttga 716821 ttcgactctg ggttttcatt ccgccctctt gaagtgcttc taagtgttcc ttagcactag 716881 tattattcat atctgaggct gccgcagcag tgcgagccct cgccgctgcc tcaggatcct 716941 gctcctccca aataccacct ctgtatactt cattaggtgt tggataaaaa acaatatcat 717001 ccataaacgg tacaactagg gactccttca cggcttcggc aaacttactc tttatagcgt 717061 tagtaacgac gttgtatgat aatttacttg aactgacaat gggctcaatt tcaaaatcca 717121 ttataggttc ggtgcgaaaa gcataccaaa ttctgttaga tggaggtggt ttgattaaaa 717181 ataaaagtgg accggaaaat tctttaattt ttatggacaa ctgcaaagaa acctcccttt 717241 gtttgaaacg tgatcccaag ttaatactcg cctttgtcgc aataataatt gtcaagtttc 717301 ccctgtattg aacgtcgata gcaatcttag tcgaaccctc aggagacaat tctaataact 717361 caggagaggt gaataatgga gcactatcac ccacgtcgac cttttcaaca accaaatcat 717421 ccaagaaccc tggggttttt attttattca atttcttgca gattttctca tgaataaact 717481 tattcaacgt atcagtttgt tgcagagaaa gaaataatct cccaagaaga gcattcagcc 717541 acttagtagt taactgattt tcagtagagt tgatatcctg aatcaattgt aacatatcct 717601 tagtcttcaa atgagctgcg ttagctgaaa cattaggatc caataaacca gttgagaggg 717661 aattactgtt tttagaggca ttgatcaact gataatacca atcttctttg tccatgttat 717721 tatcgaaata caagaagaac tgatttgagc tatggaattg tgattgatat tcatgtgtag 717781 tgtcattggt agagatgtca ccgttattcg attcagcact ggtaagtggg tcgaagtgtg 717841 gcaggataac attatggttt ttagagtcta tagaaacgag gtcattcttg aaaatagcaa 717901 tacaagttct cttagtgaaa agcgaggcat ctggcaattc ttccttaccc agttcatcga 717961 aacggggcca aatggtgata aatctgtttt gtaaagatat agcatggacc aaatttgcat 718021 tttgagaatc gtctttatac aaaaacaaat ttccatgtct taatactgca aaaaaccttt 718081 gttttttctt caagtctgtt ctttgcaaga tttgctcttg aagtgcagtg tctgaatctt 718141 tattattatt agaattcttc aaaattacag ccacttctga agaatgataa taatattgct 718201 tagtgacggt gatccaaccc ttgttaaaaa ctttgacacc taattgctct tctagcttgc 718261 gtgctttaaa ctctgggtct atatcgcgag ccagaagtct ggttttctca tcaatttcgt 718321 ctgctgtatc atgatctagc tccttcttcg atgccgattt aaggttactg tacaataaat 718381 ggattttata gagggtgaaa aggaccaaag gcaaaaatgt gataccgcca agcaagtaaa 718441 ctgcgagaaa taccttcaag ctagccatta tggtctttta atgctacttt tctcttgctg 718501 ttctgctctt cgatgtgttc aaaacccttt ctcctggtta ttatacaaga gggatttacg 718561 gagaaaactt aagtgggaga aaactgaaaa atgtgccata ccaattaggt gcaaaaatga 718621 aagatctaaa gggaagagaa ccaagagtta tttaaagggc tacatagggt gcaagattag 718681 ttaggttgta gaactagttt ttcagagtca ttaaatcagt tattttttat tttgtagtca 718741 tcaattagcc ccttcgttaa agagaccaat ctagtacagt gtgaatataa aaaaatcatc 718801 ataataaact agtccgcaac agtctctttt atcatccaaa tcaactgata aggaataaat 718861 tgaaataaga aacaaatttc cgaaaaaatc agatgtcttg tgaccaatca tcaattctcc 718921 actaaagaac cataatgcca tcaacatcgc tcctttaaaa aatttgtaca caaaagaacg 718981 atgagagtag acggcgaccc tttaacagat actaatatgt ccgcccggtc gacaacaaat 719041 catcatatca aaaggaaaat taaaaattcc attgcaggca tgaaaaagat aataatgaaa 719101 gataaatgct ttcttttctt cccttccgtg gcacccctca tacaaggctg aaacttaacg 719161 aaaaagggtt gtcgacatgt agttaaacca ctattcagtc ggaacaattg gtatatgatt 719221 aataattttt aatcataggg gagtcacaca gaaagaaaat ggaaaaagaa aaaaggaact 719281 catatattat ctcttccaag ggacctactg gtcgcttaat ctgcctcttt gtagtgcagt 719341 agcactcaca atggtgctat atttgagttt gttcaactgt tttctattga agacgaagaa 719401 gcaaacaaag gaagatgtga aaaaaaaatt ctatgggtca aacttgtgct tttatacgtc 719461 gtacgagaga tgggtcaccc gcttctgagg gtttttttta gggctcatac tagagtatta 719521 tactgtttat atcttgtttt aatgttatat tgcattacta ctcatcatga cagtaaatta 719581 ggagttctgt gtgcactcca gttcgggcta aagagtcgta atcgtactgg tcaggcaggt 719641 acttgttgtc agagagacgg tacaacttgc gggatacttg cttgttgacg tgcttgtagg 719701 catccttgaa gcgcagcaga ggcagtgggt accggtccag tgctcgtcgc acgtgcatct 719761 ggattttgtg cttggcattc cgtatctgtt catacatctg ctgtgtcttg acgctgtgct 719821 tgtcccgtaa ctcaccagca aaaatcatgg aattcctgga atcgtagcta gcaagttggc 719881 tactgatagc acccatgcgc agctcgagca atgcatttga tctacaatct gtgcactcct 719941 gccacgtatt gcgatcgccc acctcacaag ctagcccgcg tagacatgtt tcgtgatata 720001 ttgcttcgca gtcttggcaa tacaggctta atcgagaaac atctgtgtct ccgcatatgc 720061 tgcactgaat tatcttaatg gtatccatca ccagcgtacc tctaagcctt tcgctgagaa 720121 attctatttc ttggtcttgc tcccctgtat cgtcctcatt tctttcgtta gttgtttcgg 720181 cccccacata atcgatagca ttcttaatca taaaccccat cttcaaattt atagaaagtg 720241 catgttgccc ttcgccaact tctaaatggg tggattcaac cctgcagatg gggcacttca 720301 agttgatact atacttgtgc cactctctta tacagtttaa gtggaattta tgcccgcaaa 720361 cgttcaaaca tccaaattgt tcaccctctt ggtcatctgc caaacaaata ggacactctt 720421 ccatcttttt atatgatatt tggatatttg gctgagggta tggtctctcc cttggctcaa 720481 ctccttgcat ctttttttct attttttttt ctcactttct gttcttccat atatgcatta 720541 cttgccatat ttctcactta ctaaggcatt caacatagaa aatgaagatg gatacaaaaa 720601 agatccacac acatacaagc ctccaacaaa aaaaacatgt cccgccatca gtttgatcta 720661 ataatgtgcc taaagcagcc tggtgtacag acaggtcttc tttgtgaaaa atgtgatggc 720721 aaatgtccta tctgcgactc ttatgtaagg cccaaaagga aagttagagt atgtgaaaac 720781 tgttcgtttg gtaaacaagc taaaaattgt ataatttgta atctaaatgt tggagtcaat 720841 gacgcattct attgttggga gtgctgccgc ttaggtaaag ataaagatgg ctgtcctagg 720901 atcttaaacc ttggcagcaa tagactggat agacatttcg agaaaaagaa aaaggtataa 720961 cacatacata tagaatatgt aaaaatatat aaataaataa catgcattta taacccatgg 721021 tactattttc ttccccttat tcgttactat attcgtcgta actactgtcg ctcacgcaca 721081 cttgcaaact gttctcgttg aataagaagc tttcctctat atcatctata ccatcactat 721141 cgtcgttatt gccttgcccc tcctcttctc ctttaccatg ctctaagata ttcttttcag 721201 cctgcttgcg agtcacttct tttatgatac ttacaaacag ctcgcttctc ttaatttcgt 721261 agattaacca gtccattctg acagccagct gtcttatgcg gtttatcata tctgtcttag 721321 tctttgtgct aataggaaca cattttccca taagcatcag agtgctttca aattttttca 721381 atttctccca tttggctgat tttatagacc taagtctttc catcctctgc aaaatggtaa 721441 gctttctctt attacaaata gtgtttgcta tactaccaat ttccacatag catccgtcat 721501 atgctgaaaa tagattgata gaatcgatcc agttgtccct ttcatactta ttagcacatt 721561 tccagataaa atttcgatga catgtatgta agtataatag acaatcggca ttttcgtctt 721621 cgaaaatcgg atactcgtcc ttaatggaat gataatcttc attactgtca tttgaactga 721681 gttgattatc tgaactagaa acactatcgt tgtcactctc gccgttactc acactgctcg 721741 taccatcagt agaattcgtt atgctatcct cttcatctga agatggctcg aagactcctt 721801 cattgtgttt ggcggagcta cttgctgcag ttgtgttgct tgtatgactc ccagtagaat 721861 gatgctctgt atacgcaagt accaaacttg cgaaatgaga tttcccaagt gaatctcgct 721921 ccctatcagc aaataaaccg ttatacacgt caatcgtact tcccggaaca aaagaaaatc 721981 ctgatttaaa atcaattata tagtttgtag ttcctgattt tgggtccttc atcatctgtg 722041 gatttatcca gtccatttta tcgcagatca aaagccccaa tgatgttaat atggcaaatt 722101 cctttttcca atgaatttta gcggagttaa caatagaaaa ttttctactg ggcatcccca 722161 aattcattat tgctcccatt tgaaggattt tgcaatactt ataatcggag ttcttgcatc 722221 cagaccggct attatcattc aatatttcaa aattaggtaa attcagttta ttcaattgac 722281 ttttgtgaaa gcgtaaatac ccacctttag tatcattcat aatactataa tatttttcgt 722341 atttatgttc ttcatttctc aacaaatttg ccttcagagc attcttattc caatattttg 722401 agacttctgg aaatagattt acttcattta atgtatcatt tataatgtgc gaataaacgt 722461 taatgtcatc ttgaactaac gtagcatttc cgctagaact agagcttgga ttatatgaaa 722521 aataagacga tattgagtta gaagccggtc tattgctatt actgttagcc gttccgaggt 722581 tggccccgtt tatagtaccc gacgtacttg gtgggcaaga agccgccgta gatggggcaa 722641 taccagatgc actaattgaa ttcgttagcg gataaaagat tggggaaagg gaagcttcct 722701 tgggtattat actccccctt tttatcatgt ctatgggaga atacatcgaa ttcgaagata 722761 atgtgatagc aaaatttgtg tcaaatgcat ctttatcaag gatgctatcg tccaacgcca 722821 ttggtgacat caaaaagtaa ttaaatttcg gcgactcttt ggctgtcaca ttctcataaa 722881 aatatgtcaa aacggccata gggatctcat tacctcctga gtatttgtca ttatggacta 722941 aatccacgaa atcatgcttt gtcattttgc ttttattgtt ggggttaaag taatcagtgt 723001 gcaacattag taaggaaaat gcaataaaat acacctggtc tgcattagac caggggcact 723061 caattccttt tttcttagaa tagctctttt gggccttata gtatgcaaag ctaaaagcca 723121 ttatcaatct atcaatttgc tgcgtctcct ttggaagctc taaaaacatc aacaatttcc 723181 tcagggcaat atctaaaggg tcatttttaa attcgaagca attcgttaat aggtagttta 723241 aacaattttt tttgaactca tcatcttttt ccgttaaaat gatcccaatg aactttccgt 723301 agggcgctaa tttaatcaag aagtccttac aagaatcact aaattcaggc gcgggaaccg 723361 gtggtagatc ttccagcgag acatccagtt tttgttgtag ctgctgttgt tgttgaaggt 723421 gctgttgcct agaggatgat aaactggagg agcgaaggtt aacaaaacta cttaaagcat 723481 tcacaattga gctacttctt cttgacattc cagtaatagt tgaattggca ttgcttttat 723541 tgttgtaaac tgaagtaggg cctgatccat gaggtaggcc caatttgtta tggtagcctt 723601 catcttcaat tgattttctc ttgccgccct tgccttgaac aaaagacgta ctttgagatc 723661 gagaccttga taaaacctga tggtctgggt gacttgcttc cgctccatct gtatcattgc 723721 ttataatatt ggcatcatcg ggcaaaagag gtccgcggga tcccatgggg tcttgcataa 723781 gagaatttgt atttttctcg tcaatagtcc taataaaaga agatggagag agtggcggtt 723841 tgttctttgc tgtattgttt ttgttaatat agtcaaatac gtcaacagtt ctactgcgcc 723901 ttcttccgaa cctccttttg gagatctcat cttgttgttt tgccaattca atttgaggag 723961 ttgcatcaag tggtattgcg tgcagcgaat tgaattttat tgacgacgac gatgatgatg 724021 atgatgcaac aacagctctt ttggacggat tgaaatatct tgaagccgct gtagaggaac 724081 cgacggaaga agatgtcgat atcctactca cagtaggaag agtaggaact aatctatcac 724141 cgttaaacag ggtaggctct tgtgattttc tgtaatctct tgacaatcta ttagaagaag 724201 gaaatttttc tagagcaggt ttcacaggaa tgaatggggc gtgttttgaa tttctcttta 724261 cgttatcaga cccggagcta gtaagcgtga ctctctcacc atcgggcttg ggaactttct 724321 ctatcgaatc tatgttgttt tctgatttga aaggcatttc ttcaggatct tgtccattac 724381 ggaggtgttg tgcaaccaag atttcatcat cttcagaacc cttttcattg gctgacctga 724441 aattcaagtc taacctaccc atcttacgcc gtatcctgct tagtttgctg tgtttttttg 724501 tgggctcgca ttcttttaca tcaagtttat cgtcgtcatt attagtgtgt tcctgtattt 724561 ctgcgagttg aagaaaagga cttctataac tttccgactc tcttaattta tctatgcctg 724621 ttgaaacatt gcttccgccc tttttgttgc catttttatc gttactgtgt gattgaagga 724681 atttaagctt aatcaacgaa gaaatagact gattcattat ctggcaagtg tggattgaag 724741 agctggtctg gcgggaagtt agcgaaaatg aagttacaat gagttgaaac agagtaaata 724801 atagggagtg gatgcgagta accttgcgat gtcaaaagaa ttcaaagtac tatatctact 724861 gcctttcttt ccacttggtg ccttttaccc tgaaagtcta atgagcaggt agtataagag 724921 aagcagcttc tgaagaagag ttctttgtac aataaaccgg ccttgtggtg cgagagaggc 724981 ttgtaatata gattatactg aagcctgttg aacttagcgt ctattttctt ttcgttccct 725041 atatcacttt tcctaatatt ttcaacatct cctttacgcc aaaaacaaga aaaaggacga 725101 gatggccttg ggtttttaat gcttacgcct gtttcgcctc tcataagaca gataaatgta 725161 cgttaaccat ttgacagtta actttttagg cgtgaacaag gaacgtatta aagtgttttt 725221 cgaataattg atcactttct agctttcatt cttttttaag agctacatcc aattactgtg 725281 cattgggctc tataaaaaaa gaaaaacgaa ccttaccttg tggtcggaat tgtgtactga 725341 aatcagtggt tgaagataat tgtactaaag aatcaaaaat agacagtctt caaatgatta 725401 ctcaagacac tcctgcttta aatccaacgg aagaacacta cctgaagagg gaactgcttc 725461 gatgtcaatt ggattatgaa attggaaagc ttaacgatca gtttgctttg agaaagttcg 725521 gttatccttt ctcaccaaac gatccgacag ctccacagcc tatctccaat aacgattcat 725581 caccagtgct cggtggcaaa ggccatttta gcgttaatta tcccatgctg agttatgttt 725641 tgcaagaatt tatatccaca tttcctttac tttcaacaaa tttgctagtt gatgaaaaat 725701 tctggcagag taaggttcaa gtgttctttg aacatttcat gagtcttggg tttagtgaaa 725761 gttatgacag ggaggaagct tcaaaaagga agaaagtttc caaaaagcta tcaaaggtta 725821 tcttgttgct ctttaactcc ggtgttggct cttttcaaga gcaagcgtat tataatgagg 725881 ataaattcgt tttacagtca ggccaagcga gaaaacgctc taatattgag aaatttgcaa 725941 tgccaactag agaaaattta gagaatttgc tcactaacga atccgttttt attaacggtt 726001 gggacgtcaa tattatatcc gtgttcaata agaattcacg gaaatgtact gaaagtgtgg 726061 ataatgacaa gtctagtaaa tctactccaa cttcgagtcc caaaagccat gctataaaat 726121 catttgcttc cacttctaaa tggatgaaga atgccttcaa caacactatt aacagtacca 726181 taaatagtat gcccgaatcc tcagcatctt tattttcgaa attatccctt ggcgtgcctt 726241 caactaagag caagcaatct agaaaacatc attatttctt gattaagatt aagaagcaag 726301 atgacgacga ccaagataac agcaatgaag agaatagtaa tcttgatcac catgctggtt 726361 atttctatgt gacaagaaca tacagcgact tcaaaaaact atctcatgat ttaaaatcag 726421 aatttccggg gaagaaatgt ccgcgcttac ctcatagaaa taaaaaagtg acgtctatga 726481 taactaaaac cgaagtgtta cacaatgggc aaactaaatc agcagccagg gaaaaaatcg 726541 tcaacacttt tgacactgat ttacaatctg catcagagtc tgataattct tcatttttac 726601 agacaacgaa tgaattatct gctacagaaa cagtactcac agaaaaagaa actgaaacgt 726661 tgagaaaaaa tattctaaat gagatcaagg aagaagataa tattgatgag gacgagtatg 726721 aggaagaagg tgaaggtgaa gaaagtgatt ttgatgaata taaagatgca tccgattcaa 726781 aaatcaatac tttggtgggt gaaaaaatga gaacttcatt aagacaatat ttaaggactt 726841 tgtgtaaaga tgcagaggtt tctcaaagct catctattcg tcgcttcttc ctaagtgggc 726901 ctaatttaga tattaaggac ataaatccga aaatagcaga tgacattaga aacagggctc 726961 tgatagatgt aagtaatttg gagaaccaaa tacgtttcca acagatggcg ttagaaaagt 727021 ctttaaagct gcaagactca atgaaagatt tcaaaacatc cctgttaaaa gatgaaaaat 727081 acttgatgag tctactagta gaaatcaagg acaatacgaa agttgaagac ctgtcaccac 727141 ttttacaaga ctttgtggaa tggtgtaaga tttatatttc ctcaatgatt tatcaaatgt 727201 ttctgggtaa cgataacagt tatgaactct atacacaaat aagacggtta cataagctta 727261 tgccgtacac agtaatggga cagatcatga aatttactaa tccaatagcg atcatgaggg 727321 gtatgattga attatttatg gcacaaccct tcggtggtca ttcgctcctt caaacaatgt 727381 tttctacgat attaacagat gatttgaaaa ctcaaaaggt agctataaag gaattagaaa 727441 ggaaaattgc tgagatggac ccgggcgctt cagttgtgac taaatgcttg aaggattttg 727501 tctttaataa tgatactaag gatgagcatg atactaaact ctttactatg gacgcagtaa 727561 atgcagaatc cgaatccatg aacatgcctg taccattgat agtattaatg aaaagtgcag 727621 ctgcaaatct aattccagac gaggttgtcg cgggacttat tgaatcctat tcatcatgga 727681 aactgcaaaa agaagacacg gatgccttga atgtaaccag cgaagatcag tcaggtattt 727741 atttcacaca cgtcaaagat ttatggcaat tgtatattaa agaacatgat aaacagctaa 727801 tgaggcagct atggcaagat cctgagttaa cccaaatgct aaaggcaatt gtcactatga 727861 tttacgaacc tatggtcaag atcttcaaag ttgcaaggat ggatgttgct ttgaaaaatt 727921 ttgagaagtt catgagtgat ttgatcaggc ttgttgatga tgttatcaat ggtcagttgg 727981 gcgtttccac acagttcgat gtcgtggaag aaatccataa cttagtaacc aaacatcaag 728041 atgccttttt tgagtttatt catgatgtat atttgaacga ttcagagggc atttttgaag 728101 gttttattac ttggattact acgatagtga aatttttgca aaagagtaaa ttcggaggac 728161 cgagtgaaag gatcgacttc aataagttaa tttgtagaga tgatatcgat attgatgtca 728221 aacttttgaa agttcaagtt aataatgttc ttaataaaaa gattggtgcg agaaaaatct 728281 ataagaagtt gttagatttg aaggttaaac aaggtactaa acaaaataac aaacacgctg 728341 ctggcatact tcaaaagaat tggagtgaca taaactcctt ggttatgcca tccagctctg 728401 gatcttttgg acttggagat ggtgatttgg tggatttgga tctcgataca ggtgattacg 728461 attttttaca taaagagaat gaagttgaat tagaaaagca atacaaagat ttattgaatc 728521 ttgttgttga tgaaagtgaa attgataaat tgagatctca agttttcgca caggaattaa 728581 aaaattattt agaagctcaa attgctaaaa agtaggccct ttctagtatc tcctttattc 728641 gtttttattc gttacgattt tccggcttaa taatatagga ttgctaggtc tatatataag 728701 aaaagcttgt agaaataaaa aaatagaaaa aacttcaaga taaatattgt tctcttttat 728761 tttaagatcc tacaaacagc acaattcccc ttttagttat ttttagccaa gatcaggata 728821 gcagagaact gagtccctta ttctttaatt gagggtcaaa aaattccgat tgcgaacttc 728881 atctccacct tggcaaagga atgacgaaaa aatgatcttg catatatata tttacttgta 728941 aaataattat tttggaattt ttcttaacaa accacctgac aaacaaacac cgtacgcaag 729001 catcccgcaa acattagaaa gattgaacaa aagactcaat ccgtgcgact tgccaaattc 729061 tttacgtaat atagcatcct ttgcttccaa ttcactaccc gtgtatttct tcgcaatatt 729121 ctttctttgt tctttaactt tatgggtcca gggcaacaac caaaacaaat tggttagccc 729181 actgacagat gcaaccacca aagaagataa tggtcctgtt gtcaaggcaa ttggagcggt 729241 aagggccagg atgacaggtg atgccgcttg catttggaaa aaatacggga agatcttatt 729301 ttgcaaagca gaaaattggt ctttttcaag aactttgaat gcgattggag aagctacata 729361 ggaataaaac gtcgttcctc caaatctgaa agattaagtt ggtacataaa agttgttagt 729421 cagttattct caattaatca taattgttca aattttttct tgtgtcttaa tctgtacata 729481 cacaaaggaa taaaaaagca aatgagccgt agttttgact aaacacattt ttcgttgtta 729541 agtttactgg actgtaaagc gtagtttgat ctgcctatat catcaaacaa ctccatttaa 729601 ctcccttaaa taatactatt cttttctgta agtttatcgc actatacgtt acggtgcttt 729661 ccgtcttttt cggatgaggg atgctcataa gaattacaac aaatcataag ccctgagata 729721 aaaaagatca atcaatacga ttatcataaa ccatgactaa gtagatacac agacacgaat 729781 atatggagaa atggttgtga aagctattgc acgaaattcc ataggtcgta atggagttgg 729841 agcattcgtg tttccatgca gaaagattac tttgcaattc tgtaactggg gagggtcttc 729901 ggaaggcatg aggaaatttt tgacttcaaa gagattagat aaatggggcc aggagttccc 729961 atggatacag tttgaagtga tgaggaagtc tggacatcct ttgttgaggg cagaatacac 730021 aaatgggcgt gaaaaagtta tttgtgtgag aaacttgaac attgacaatg tagaaaacaa 730081 gctaaagcta ttgaaggatt ctgatggaga cattttacgc agaagaacaa agaatgataa 730141 cgtggaaagc ttgaacagta gtgtgagggg tatatggtcg cctctgcatg ctgcgaaaag 730201 gcatagaatt tagctttagt atataagaaa attctagaaa tagagagaga taattatact 730261 tgtatatata atttggggca gataagactc ctgatattta agatttaaag tcaattttgc 730321 cattgttata tgatcatgtc ctgaaatatg acctcttgta tttggttacc cgctttacac 730381 cctgcaaatc acactagtct aataaatatg gaataagact gaaacatata aaagatgtaa 730441 cttctaggat atctgaaaga gcaaccgtac ggtattcaac gtttagattt gatggacggc 730501 cttagctttg ttgataaagg gaaaatacca gatggttaca aaaatgaaat agatcaatta 730561 gtaaagaagg aatttgcgaa tataaaaaga gagcctgttc atcccgaaat acgaggtata 730621 cttgcgaaga gaaagggggc cgataatagt gtttctacgc ttacaaatgc attgtacacc 730681 gaatacttga aacaacgtaa taacaaaaaa aggcgaacac cggattttaa tgacgacgat 730741 gatactttat ttttggaaga gtatagaagg aaatacccga ggattgatac ttccagatac 730801 ataccgaacg agtcttccga agttagcttg ttaggaattg tagattctta tttaaaacat 730861 caggaaatag ttttggatac acttctaccg caaacggtat cgaatcaatg gagaattaat 730921 aatgattata ttcgtcaaac gtgtactata gtggaagaaa tgaacatcca gcagaggaaa 730981 caaattaacg atttggaaat atacagaaag aggttataat gtcgcaatgg acctttatta 731041 ttataaatgt ggcggcaaat cgtggaagga tattggatcg ctcgccatag aagtccttag 731101 cgcgcatgta caataacata gagtttcatc ttggtttaaa attcataatt ttattaattg 731161 gttacaaaaa aaacatagat atgagtatat aaatgtatta tatttcttca caaactaatt 731221 aaattatttg tccaaaacat cagcatcgta cttttgcttg aaccaagaga cggtgtcttc 731281 cttagttgtc ttgtgggagt taccaacggt acccttacat ctctttcttc tagtgactct 731341 agcacctggt ctgttcatga cgacatagaa atccataccg aaaataccga tggatgggtc 731401 atacttgata cccaagtcaa tgtgttcgtc aataccgaaa ccgaagttac cggtagcaga 731461 gaagtttctg tctctcaatt ggtattcctt gaccttcaaa cctctttcca aaatttcttc 731521 agcctttgga cctctgacgg taacgtgaac agcaattttt tcgtttcttc tgataccgaa 731581 agttctgaca gtgtatctgg ccttggattg aactggagtt tgaccagata attgctctaa 731641 aaccttggag gctctggtca atctgtcacc agattcacca acagaaatgt ttaagaccaa 731701 cttttcgatc ttcaaatcac gcatagggtt ttgagctttg gcagacatct ttggctatgt 731761 ttgtatgttc ttggttcacc ttcccttcca ctgaaaaaaa aataatatta gttgaaatac 731821 aataaaatat gaactaagaa agaagcctgc ggttactatc aagatgtatc aaacaatgaa 731881 actttcgcat agctgagtgg taagtgggct acctttgcta gtgaaacaat aattccctgc 731941 aaagtgaaaa agttcgattg gaaactggtc acgtggatgt gagtctatta cccgtagagt 732001 ctgcgcgctg tttgcgtcgc tctctgtatt tctatggatt tcaccgttct tttttcattt 732061 atacaaaaaa gacagaactt aatgaaataa tcgcatcgtc agtacaccca tacctttagg 732121 atggttggat gttgcgctgt cgcaggaaag agcctctccg ggtattatgt gatatgaggg 732181 aaaacagcaa aagggtggca aaacgaagaa tagcactcct tcaataatgc aaggtgaatt 732241 gtaaagaaag gcttcaatat atcaattttc aaaagagaat aacaaattta ctattaaatt 732301 gaatagatag aaagaaacca gaaagaaaag aaggaaaaaa aaacaaacat gcaagctatt 732361 gccgatagtt tcagtgtacc aaacagattg gttaaggaac ttcaatatga caacgaacaa 732421 aacttagaga gcgatttcgt aacgggcgcc tcccagtttc aacgtttggc accatcgctt 732481 acggttccac caattgcgtc tccacagcag tttttaagag cacacacaga tgattcacga 732541 aacccagact gtaaaatcaa gatcgcacat ggtactacaa ccttagcatt tagatttcaa 732601 ggcggtatta ttgtggcagt agattctcgt gccactgccg gcaattgggt tgcttctcaa 732661 actgtgaaga aagttattga gatcaaccca tttttattgg gtacaatggc tggtggtgcg 732721 gcagattgtc aattttggga aacttggcta ggttctcagt gtaggctgca cgagctgagg 732781 gaaaaggaac gtatatctgt cgcagccgca tccaagattt taagcaattt agtataccaa 732841 tataaagggg ccggtttatc aatgggtact atgatctgtg gttacactag gaaggagggc 732901 ccaaccattt attacgtcga ctcagacggt acaagattaa aaggtgacat attctgcgtt 732961 ggttcaggtc aaacatttgc atatggtgtt ctagactcta actataaatg ggatttatcc 733021 gttgaagatg ctttatatct aggtaagaga tctattttag ctgctgccca tagagatgct 733081 tactctggtg gttctgtaaa tttatatcat gttaccgagg atggttggat atatcacggt 733141 aatcatgacg taggtgaact attttggaag gtcaaggaag aggaaggatc tttcaacaac 733201 gttattggct aaatagaagc atcaaacata tgtatatgca catctatatt aatgatacat 733261 tattctcttc aaggatccaa tatggcttcc catagaatta tgaaggaagt ccagttctca 733321 tgtttccaat catcacatct atatattttt atataattat atctttaagt attgttcggt 733381 aatatgagga cagacgccat caatgcaaac aaaaagtgaa acccgaaatc aaacgaagtg 733441 aataagtagt tgtagaggcg acccgatgga aaattttgta aaaatcgaag actgaatctc 733501 aacaacgcaa aacagaatag gacgcataga ttcataccta ttactatggc ttgatccgat 733561 ctatctttat gaaaagattt atgcttctac ttcgaatatg ctaatactat tatcgaaatt 733621 ttttaaagtt tttcctcaag ggatacattt acttcagtga taccctcgtt gatatcctcg 733681 ctgaccttcc gccttttaga atcatgacct tcttcgtcgg tttttgaaat ctcgcgatta 733741 tcattgctac tattctcgtc tttagatgga atatcatctt tagattcgtt gtttttaata 733801 ctttcactat cgatcttttc gtttttgttg ttcttttcat ctacttcgct tccactatca 733861 ctttcgcttt cgctttcact actagtgctg ctattatcgc cgcttccact agcactaccg 733921 tcatcgctac cactatcgct ctcgcttccg ctctcactac tggaactgct actactacta 733981 gtgccgcttt cactttctaa gtcgttgtcc tgtgcaggct taggtttggg ttgtgcatca 734041 acattttgag aagcagccgc cggaactgac gtagctgcca cagaggatgt agccctagca 734101 ttttgtctcg gttgaaaaaa tcgagacaag gacgaaggat caaacgatcc cggttgttta 734161 tcatgcaagt aattattggg atgggatgat gccgacgcag ataactgaga tggaggccta 734221 tctggtacat gcggcgtctg gactattggt tggcgtatcg gtttggaatg ctgtgcctta 734281 gctgctaaag ccgccgccgc tgtagtttca gggttcacta attgctttac ctcacctttt 734341 gtgacttttg cagttgccgc gtttacagca gctgctaaaa ttagattcaa atgctgagga 734401 ttcttgtcca tcaaggctgt aagtggatta ccagtaatcc ccttgttttt tgccgcttgt 734461 gtaacctgat ttattgtcat agctagagcc tgcgtcaaaa ttgcagcgat gacctgcttc 734521 gataaaccct ttctatctcg tgttaaaatg acaagctgtt cctgcagata tttcattgtc 734581 ctttgattat cacttgctgt atttttcctg ttcgaggcgg ctctgtttgc tgcaagagtt 734641 tgtgagatgt tttgttttct cgcattaacg ttagatctct gcgaaacaat atcttttttg 734701 cccctctgcg gcacttgctg aagtttgtgc tgttgctgtt caagttttaa ttgtgcagct 734761 tgtgcctttg ccacagctat ctcactttgt ttctttttct gtcgttccct ctctgcaata 734821 tattcttcat caagacccca taaccatcct ttgccttctt tagaaacctt cctgaaagat 734881 ttatttagcg ataagttgtg tcttaccgag ctttgccacc catcaggaca gtatttataa 734941 taggggaaga gttctcttat tcctgcataa atttcagata aagacattcc cttggcagtc 735001 gagtactttc gtatgcaagt agttagcata gcagagtaag atacagtagg tttcgttcta 735061 tattctactg gaatctcctc caaagtatat actttctttg gtattttcgg tggcttcttt 735121 tctttcttaa cagctggttt ggtctgcgct ttcttgggct ttgctccagt tgtaatcttt 735181 ttcttagatt tgggctcgtt ttttttgaga tttcttgtat ttatttcaga ttctgctatg 735241 tcagcgtttt ctgggctttt gctatcgtcg ttacgttctt gttctggtaa aataaattga 735301 aatggaattt gtccaatttg aatttttgtc ttattacgaa gtggcacagt atttcctttt 735361 tcaacgaaaa tgtcatccac aaaagcacca ttcttcccta ttatggacaa ttcgaacctt 735421 cctgtcccaa aattgtaaaa aatctgggcg tgtctcctcg atattgattt tgaaggacca 735481 agattaacgt caactttgtg ggagaagtca ttctcagacc tccttccgat tattgcatgt 735541 aatgtttgta cataaaatgt gaaactttga aagtccagcc ttgcataggc gaagatagtc 735601 ggttgttcat tcggtagcgg taaacttgca tcgattggct cagatagttt tcgttgggta 735661 gtttcagcat ctgtactatt attttccgtt acagtgtttt gtggcggttg tcccactaat 735721 tcatgctgct gaaacattat tggcgttatt gaattgtttc tcatatgcag catgttgttt 735781 ttttcatcta ctaatgttgg tagggtctcg gtatctttgt ttactgataa tttatgcaca 735841 tctgtgtata tagcatcagc agtgggttca tccttttgta tacttgtatc ttctgagttc 735901 cttatgcctt cagttttcac tgctgctgtg ttatcttgag ttttctccct ttcgtcctca 735961 tcagggttta ctggctctat attgatatct tcttttgatg aaacctccct gctgtgatca 736021 tgagttaaat cgatgttatt tacaggatcc atggtgtggg ataacaactc atttgagttg 736081 aacagagctt catcattttt tgcatcaaat tccagtagct tcgaaaaatc agcgttatca 736141 aggttatcag gtaattcaag tttcaaattt ccattatcgt ctgtaacagg attctctacc 736201 tcgttttcaa tatcagtagt cgtgttttga ggatgttttt cctctgttac tatatcagaa 736261 ctttttggta gttttgtttc aatcggtacc tcgcttgtcg gtgaatttgt tatgctttct 736321 ttggtttctt ggtctttcaa tgcggaagaa tctatagtaa actgtgtttc agtggtaggc 736381 gatgaagtcc cgacatgatt gctgctttct attattgcca tttccccatc catcttattc 736441 ttatatttgt atagatatga gtgggttttt gttttgagcg gctagacgtt aaatcaggta 736501 aaaaccagta ccaggtatat tatggtaata aaaaaaggag aaaataaaat gctttcaaat 736561 acaaaattaa tattcgtgat gaccttctac aagagaaaaa aatgtgccaa tagaaaagtc 736621 ctatttatcc agcccagaag ataatagcaa atattaatag actttaaact aactcaaagg 736681 atgacaaagt tggccttaga gaaagagcta ctcctttctt agcttggtga cggaatatat 736741 ttcaaaggtt cctttgttta ttttttatta acgcttttaa tttttcttgt cttagtcttc 736801 gtaatttcca gttaatcgca acgttcagaa tgatagtatg gcgctatcat gttgtgctct 736861 ttcataagaa aaataagaaa tgtattaaca gtcaagagta tgcagaaaag gtacaacagc 736921 caagattatg tttgcgttta tatgaaacta cttagtattc agctcgtaaa gcttatgtta 736981 tatttactgt gttctatcaa tcttcatatt tctagcttta attctttcct gagagtttat 737041 cacccaatcg aaagtaccat tgaagtcatc cttgatatca cctgtagtca aatcaaaatt 737101 gtcatcatct aaaccgagaa gcaacacgat ttgtgtcaat ttcaagaact tctctctgag 737161 attatagttc aagccacaca tattgccgat gaaaaggctc agttctctat ctaatttcgt 737221 aacaccaagt tcattgaatt ctagagtcca tattctttgc tccaatgttg ttacgatgta 737281 gtcgactatg acagatagca actctgcata tgcttcgttg tgaagaatat ttttgtaagg 737341 gataatcaat tggttccatt tgctattgaa actgttaatt tgcgacaaat cttcgaaatc 737401 ttctatgctt gtgatgtaat tcttttggtt cgaacctgca gaataatcgc gagacacatt 737461 tttttgattg gacgttgagg aatttgatga ggctgaatta acaaaaacag ttcccaataa 737521 gttccgaacc ctattttgta ggatattttg gaacaagtat ttgacagccc atttgcttag 737581 cttatctgtt tgttccagga ctaatttttc tgagtttata attaaattct gtaactgcgc 737641 tgcatcattg tcaaaaggga aattgtctct caaaatcctt tgcgaatcgt cttctaatat 737701 ttctatggat aacagcctgt gaacgtatac tttactcaag tacaacgtgt tcagatatat 737761 caaataatgg tgcaacgcaa gaatggaatc ctcgtcctct gcaactacgg cttgtaaatt 737821 tgattgaata tttgtcaaag cgctagctgc tgcccctcta aaagtgaacc tgcttagcgg 737881 agaaaactta tttgcaggtg gagaaaccga tcttgatgtt gcagattgct cctcaccttt 737941 tggaatgtat cttttcaaag atacattgga ggctagtttc gattgtagta acttaaattt 738001 gttttgcata aattttacca gaaatcggtt ctgaaaaaat tttaccaact cgttcaaaaa 738061 acttgctaag agcttaaact ggccagtatt aaccactgat atcagatttt tccgaactaa 738121 taaaattaag tcatctaaaa cagatgttac agggtatgaa atgttatcgt ggtcattgag 738181 gggaacagca gttataagat cgttcagtga cggtaattct tctagtgaaa tactatttct 738241 aaatgatctc tgcagatggt tcaacacaaa cacctgaaac tcatcaaaga ccttatcttg 738301 ctttaacttt aaggcaaatt taccatctgc tattggtgga ggtggttgca atacatgcgg 738361 atgcaaatcg ctaaattcat tccatttaac tgaataaaat ctagaataca tggaccaatt 738421 ttgaagtatt tgagaaaatt ccattatcaa taatgccaag tcatgaatgg atataattga 738481 gctcttttcc gtttctccgt ctgtttcgat atccgactga ttactgtcta tattcacatc 738541 ttcattcttt tgtgaatgtt cccattcatt tatatcatgt atagtccttt ctattttcct 738601 cgtctccata aaaatatcta gaatcaaact agcttgaaga tcagcttctt tttctacttt 738661 ttccatgaca tgcaccatgt gcttttttcc ataacacgtg gcgatgactt ttgaatgatc 738721 atttataatg gtcgatacaa ttttaaaaag atgtaacagt acttgtgaaa aaaatccttg 738781 aaacttggtg ctgttttcca tagaattcga cataattttc ctgctttcgt ccgcaataat 738841 atcacagaca tatttggaat acaggtctaa accaagtacg tcctgcccaa tcatagggaa 738901 cattttgaac attaaggtta gctctttaat atcctgtgtt cttgttgctt ccatgaattg 738961 ctcctgaaat aaacttgtca gttccttaca ccaattcttt attagtatag ctggttcttc 739021 gggaatttca ctcgagggca caactttctt ggcaaactcg gatacaataa gttttttatc 739081 cggaaggctt ctaatttcat tgattgctgt cgcagcaact aagtaatcct ttgtttctaa 739141 agcagaatgc gccagtgaaa tattattctt tagcgtcctg acgtctttta caaattgtaa 739201 cgttttgttg accaaagcgc gttcctgatc tacagtttca atatcgtcat gtatagcttt 739261 tgctcttgcg ttcgaagaag aaatggtggc cacagtctca tgaaactgag tcaaagtagt 739321 cgtaaggtta gttctttgca attctaattt ccgggactct ttgttgagcg atgattgcga 739381 ctgttgcaca aatgcattta attgtttaga ttgttttgcg taatcattgg ctatcacttc 739441 agacagcttg tctatttgag atagtgtcga taatttgtct aataacaagg tgtaccttgc 739501 tagattttta gacaattggc cctcgatgat cgagctctcc catgatgcat tcgatttttg 739561 cccttccatc aaaacttcac ccttttagag cctgacaata cagtatcgtt agtttgcgct 739621 acttcgctgt cccaacgaat ttggtttgtt ttctatgttc tatctctatc ccacactttt 739681 ttcacaattc ctttacaggc gaaaattcaa aaaagtgacg taaatggagt tctaaaagct 739741 aaagcaacaa gttaataagg ttagaagatc gtaaatgtgt ttcaaaagtt gcttacctcc 739801 ttcactatat ctcagctgct tgtatagcct atgacgaaaa tttatgttcc ctagcaagga 739861 tataatgtgt caatcaacat gatcgcaaac cagctagatt gtgatgtatg ggtctatctt 739921 attgtttatt ttgactagca ttgaataaac aaaaagcgct gctaatagat tcttgccttt 739981 atataacggg gatctaacct catcaacagc aaaaatcgtc ttaaaacaca tctcaaagac 740041 tagttctcaa acgtcacgct atgaacagta cacctcctac gtcacccgtc accagggttt 740101 ctgatggttc ctttccatcc ataagtaaca atagtaaggg ttttgcttat cgccaaccgc 740161 aaaaacataa aagtaacttc gcatattcac atctggtatc tcctgtagag gagccgacag 740221 ctaaattcag tgaggcattc cagacagatt attctagtaa ggcgcccgtt gctacctcgg 740281 aggcgcacct aaagaacgat ttagacgtat tgttcactac cccccggttt tactctccgg 740341 agaatttggc tttaatgttc cgtctttcta atacagtttc ttccctagaa tttctggatg 740401 agtttttgat gggcatatta cttgctccag agatggattt tttgtcaaat ccaagttatt 740461 ctcttccgtc taacaaatta gtgggacagg gaagttattc atatgtgtac cctatatcat 740521 caagtgcttc atcaagatgt aacaacgatt caggggttgt tttaaagttt gccaaatcac 740581 agcataaaag caaggtgatt ttacaggaag ctttgacgct agcatatctc cagtacatga 740641 gtccttcaac caatgaaagt catattattc cattctatgg gttgacatac ataactaaat 740701 cccattttag aagactgagg tccaacgaat gtgttcctgg ccttattctt ccgaaatgcg 740761 aaatgagttt atatcacttc aatacagcag tgtcacataa gctttcgttg ataacaaaaa 740821 gaaaaatatg gtggagactt atgaagcaaa tgatagacgc attaaaatct ttgaaaacaa 740881 atggtataat tcatggtgat ataaaaacag caaatatttt aataacagaa atgcatgttc 740941 ttaatggagg ccattgtaag gattttgact tctaccttgc tgactttacg tcggcatttc 741001 acattaatca aacaccaaca gatctgaata ccacggtaga atactgtgca ccagaactaa 741061 ttgatagctc ctccgatcat gttcctacat ttgaatcgga tttgtatgcc gtggggcttt 741121 gtcttttatc atttatatcg cagcatgagc cttacaacga acttcaggcg ttagtgtcgc 741181 atggatcctc tccaggtatt ggcagttcat ctatacagca gtcccaatgg ctgataaatg 741241 ctcttttgaa aaaagatcct ataaatctaa acatgttaag aaacgattta ttccaggatt 741301 ggaagtcaga actagcatta ttgtccagaa ttctggttga tagacttcct ctagaaaatc 741361 tcataactat actcgatagt aactatatat gataatatac atgtctatga aatcgaaaac 741421 ccccagccat gcatagatca aacttcaccg tttataattg cgtttaaacg cctttccttt 741481 tcttcatcca ttttcctggt atttatctca tcgtctctct taattcttaa tttactacct 741541 tcatctggga ttatgaactg tggatgttcc atatcacatt catccttccc taaaggacaa 741601 aatccggtca tgtatctttg acagaaaacc ttcttaatat gccgtctagg acaagaactc 741661 cccagaggac agaatcccat ttcgtaattt tcacattttg gtatcttgct agcgggatct 741721 atgtgtagat attgacaatc tggactttgt gtacagtacc cgtttttgct gaagaagaca 741781 cattcaggca tttttcgaag attgtattca tgtaagtatt cacattggtc attctttttg 741841 cacaaccctc gaagccaatg tctacaaaca attttattct gaaatattgg taacacatgc 741901 ttttttggac ataacggtcc cctcggacat gatttagggc cttctctaga attgtaaaat 741961 tcacaaatag gtctgtcagg atcgagtgaa aacgaatact cttgcctgag gaaaggttca 742021 aatttaaaag gatattttgc tgtatcgggg tgaattaggc tcattacata aacttattga 742081 ttttattcgt cctagaatac ttgtttaaga tacagtgcag aaatctttag cttataattc 742141 agaaatgtga tattttgaag cgattggaac aacaaagtac agtgcattct atataattat 742201 taaaagttat agtggactat tgtaataaca cttgttttcc ccatatcata accgacggcg 742261 cgtaaatgca tgctcaatca agtttccgaa taagttaagt ttgccaccca ttgaggatta 742321 atatacacaa ggcagcattg aaaaacctaa ttgttaacac tacacaaatc tctattgttg 742381 tagtaaactg cgctttttac cactgttaca atagttacta atacacgcaa aaattctgga 742441 taaacacggc aaaatggtag acgtggaaga gaaaagtcaa gaagttgaat atgttgatcc 742501 aacggtgaat agggtgccca attatgaggt atctgaaaag gcgtttcttt tgacacaatc 742561 aaaggttagt attgaacagc gtaaggaagc ggcagagttc gttttagcca aaattaaaga 742621 ggaagaaatg gccccttatt ataaatatct ttgcgaggaa taccttgtta ataatggcca 742681 atctgacttg gaacacgatg aaaagtcaga ttctttaaac gaatggatca aatttgacca 742741 ggagctatac aatgaattgt gcaaaaaaaa tgaaagtaag attaaagagt taaatgaaaa 742801 gatccaaaaa ttggaagaag atgatgaagg tgaactagaa caagctcaag cctggattaa 742861 tctgggtgaa tattatgcac aaatcggtga caaagataat gctgaaaaga cgctagggaa 742921 atcattatcg aaggctattt ccacaggcgc caaaattgat gttatgctaa caattgcaag 742981 gctggggttc ttttataacg accaacttta tgttaaggag aagttggaag cagtcaattc 743041 tatgattgaa aaaggtggtg actgggagag aagaaataga tataaaacat actatggtat 743101 ccactgcttg gccgtaagaa actttaagga agcggcaaag ttattggtcg attctctagc 743161 aactttcacc tctattgaat taacttccta tgaaagcatt gccacatatg catcggtcac 743221 aggtttattc actctggaaa gaacagacct aaaatccaaa gtcatcgatt cacctgaatt 743281 gttatcttta atctcaacaa ctgccgcact acaatctatc tcgtcgttaa caatttccct 743341 ttacgcgtcc gattatgcca gttactttcc atatcttttg gaaacatatg caaatgtttt 743401 gattccatgt aaatatttga atagacatgc agatttcttt gttagagaaa tgagaagaaa 743461 agtctacgca caattgttgg aatcatataa gactttgtcg ctgaaatcta tggcaagcgc 743521 atttggtgtt tcggttgcgt tcttggataa cgacctgggt aagtttattc caaataagca 743581 actaaattgt gtcattgata gagttaatgg gatcgtagag accaacaggc cagacaacaa 743641 aaatgctcaa taccatctgc tagttaagca aggtgacggt ttgctaacaa aattacaaaa 743701 atacggtgca gcagtgagat tgacagggtc agatcgtgtt tgaggaattt acattattta 743761 gcaacgcaca taatcacatc aacatgtata catagtttgg agacttgagt aaatagtagt 743821 gagaggatat atggatcggt tcaagtcaaa ggattgtaat catcctcttt ctcctttaaa 743881 acggagagct tctatagttt tcaagcttcc attaaaaatt tcagtattta gttcggaaag 743941 ttacataatt gcaatgtctc ataaaggacc atgcttcttt tgaaagtgag gaatctaagg 744001 ctgaaaatgc caattcttaa aaagtagtat aaccagaaaa aggaatcccc ataaaaggaa 744061 attcatgata cggtcattgt ttcttcattt gtttaatacg ttgtattcga gtgttctagc 744121 caataaacga ttcaactaaa acacttctgg ttcgctttta gggatatcgt tgaaatgaaa 744181 tcactccatg atagtttaag tgttacagac attaagagaa gtcggctgca aatttccatg 744241 cagacacttt gtcccttctt ggaggatacc ctacagtgta aaagcctcct tagcttagtg 744301 gtagagcgtt gcacttgtaa tgcaaaggtc gttagttcaa ttctgacagg tggcaaaatt 744361 ttttccctaa agttaacact tatttagctt ctttttatat aaaaaatcca tgagaattga 744421 ttctgcattt tagtttaaat tttttcttta agactatgat gctttcatgc acaaggttat 744481 attgttctcc ttctctatag ttattgcaag gaaatcatat ataacgaaac acaatttgat 744541 ccttttgaac ctacattatc ccgcactctt gacgtatcat caaataaagc taaactgcgg 744601 aagcctaaaa atactaagca cgctatttgt catccattag caggccaaaa gcaaactaat 744661 ctatgttttc aataaggcca atataataat ggataatttt gaaagtactg ctgaaggaaa 744721 tttaagtata ggaaacaaac gagtatacga actacgaaaa agaaacttcc aaagaaattt 744781 ggtgaataat ttgagctttc tcgggtatgt tttaatatca ttggaatata tcaagtatga 744841 tcgtaccgtc tggacactta taacaagagc aatagtgcaa tctctcataa gttctccttt 744901 tccaagtgat gccaagttac gtaggctagc gaccctcggt gcagataata acacgacggg 744961 ggttgcaaca cttccaggcg gaagatctat caggtttccc ggaatgtttg gaacagaaat 745021 gctttataat tcttctagtg aagctgagca acaagaccat gatgataccg ctattgtgtc 745081 catgaaaaag caaatccgga agtttttatt tcatggttgc ttatcgttga atatgctttt 745141 cattatctta acaatcctat tcccaattga tttttttgaa cccctgagtg gtagcgagcc 745201 agtagacgat ggccctaaga atactccctc acccttttcc aattcagatg gtctactttt 745261 gggtgagaga agaggtgggc tttttctaca gatgatcgga gaacggctac caaagagcaa 745321 cttttccggc aatcttggat tagtaatgtt cgaatttagc atacttattg tacagtttac 745381 tttattttca ctaacatgtg ttgtattggc agatttagat tttgaagagc cagaaagact 745441 agaacctgta aatagtgatg gctacgatgg ctctgtaata gttgcacgaa taccattaaa 745501 taaaaccatg aatgccattt taaatgacgg caatattaat gacaacaatg agaatgctag 745561 caattctgtc taatagtata tatatgtagt ccataagggg taatgcatat tactgttatc 745621 ggcactattt tatagagagt tacatttaca tatatcattc tattacattt ccttatctat 745681 gacgattcat gggtttgtat ttttttggta ggatttgcca attctactaa tactagaaga 745741 aaagattata caaagataaa gaccctgagg ttaagtattt aatatttttc tcaaactgtg 745801 ttttttttat tagtatgcaa agtaggatca ttgggtaatt ggacagtttt tcaaatactc 745861 agccttattc tttaaaatcc tgacggattt gaaaaaaatt tcttctggtg tcatggcacc 745921 agcgctttct acgttgaaaa taaagtggtt cctcactctt cctaatttaa ctttatcagc 745981 aaactcttcg tatcttaaaa cctccctgga aaccgtatcc ttcctagcat ctttgacata 746041 cgcttcatct gaaccttcat caataccaat aacacctggg ggaaaacatt tttgaaatct 746101 tctggcactt tcacctttga ttggctgtaa gatattgatt tgaggtaata atctataaga 746161 agcggtggaa actggtgaaa atttagcatg atcaccaccg atacctaaaa tgcaatgtgc 746221 cttcaacgaa atttcttgac caggccttag cttagctaat aaaatatcag gatcagctgg 746281 aacaaccgga caatcagcaa aagtggtaga ttgtctgccc tgtggttcaa acttcaaatc 746341 acgggcgtag acatgggcat tgttatatag ttcctttgga tcagtagatc cctttggagc 746401 atctggattt cttgtgcact tcacgttcaa actcaaaacg atagtatttt catccgtaaa 746461 cttttcatcg tccggcaaat tactatcaac ccatgtgagc atatcagggt caacttttaa 746521 tggaaccaag cctattctat gagccaaaac ctcatcttgg ataacggatg tattgttaaa 746581 aaaatagacg tattcagcag ccacggatgg aacctcggaa atcattatac gacgaaaggc 746641 attcgcaatc gatgtgtcaa tgtttatcaa gtcgaaattt gcctctcttg cgtctaatga 746701 cgaaatattg acttcgaagt cctttttgaa tttttccaca ttccactcgt tttctgcatc 746761 cttcgagaaa ccaggaaaat ccgtggaggt tgtattcgtt acacggttat attcaatacc 746821 cacaatattt gacatatctt ctttcaccta cttactttca tgcacttgat acctgctctt 746881 ctacataata tgagtgaaat tttttctttc aactcatcgc aataattttt tcacaaaatt 746941 tttgtgaatc caagtcacta taaacggaat taataaatat ttgcaacata aagcacaatg 747001 tattgtagca gaagacaaac gacaagtatg ggataatgca acatctcttt ctaattaata 747061 taaaatcaag aataagcatg tcttctgact aatttttata tacaaacacc aagatcataa 747121 atttttgtct ttgaatggat aattaaccca tacacctcat acaagatttt gagagtaaac 747181 acaaatcaat ggacctgtag tcggctagat cacagatcat gatgaactgt attgtcgcaa 747241 caaacttgta actccaatag tgattagcaa cccagaatat cgtattcaac aataattcgg 747301 tagtcatgtt ttcacgaagt gatcgagagg tagatgattt ggctggtaat atgagtcatt 747361 tagggttcta tgatttgaat attcctaaac ctacttctcc acaggcgcaa tataggcctg 747421 ctagaaagag cgaaaatgga agattaactc ccggacttcc aagatcatat aagccgtgtg 747481 attcagatga tcaagatacc ttcaaaaatc gcatttcatt gaatcactca ccgaagaagc 747541 tacccaagga ttttcacgag cgtgcttccc aaagtaaaac ccagagagtt gttaatgtat 747601 gccaacttta ctttctcgac tattactgtg acatgtttga ttatgttatt agcagaagac 747661 aacgtacgaa gcaggtgcta agatatcttg aacagcaaag aagtgtcaaa aacgtttcta 747721 ataaggtttt aaatgaagaa tgggctttgt atttgcaaag agaacacgaa gtactgagaa 747781 aaaggaggtt gaaacctaag cacaaggatt ttcagatact gacacaagtt ggacagggtg 747841 gttatgggca agtttatctt gcaaaaaaaa aagacagtga tgaaatttgt gctttgaaaa 747901 tattaaacaa gaaactttta ttcaaactaa acgagacgaa tcacgtcctt actgagaggg 747961 acatactaac cacaactaga tctgactggc ttgtgaagtt gctttatgca tttcaggatc 748021 cagagagcct atatttagca atggaatttg tacctggtgg tgattttcgc acattgttaa 748081 taaatacaag gatattgaag agcggtcacg caaggttcta tatcagcgaa atgttttgtg 748141 ccgtgaacgc gttgcatgaa cttggttaca ctcaccggga tttaaagccg gagaatttct 748201 tgattgatgc tacagggcat atcaagctga ccgattttgg tctagcagca gggaccgtat 748261 caaatgaaag aatcgaaagc atgaaaatac gcttagaaga agtaaagaat ttggaatttc 748321 ctgctttcac agaaaggtct atcgaggata gaaggaaaat atatcataac atgaggaaga 748381 cagaaattaa ttacgctaac tctatggtcg gttcgcctga ttatatggcc ctagaagttc 748441 tggaaggtaa aaaatacgat tttacagtgg attattggtc attaggctgt atgctttttg 748501 aaagtttggt tggatataca ccttttagtg gttcttctac taatgaaact tacgagaatt 748561 taagatattg gaaaaaaact ttaagaaggc cccgtactga ggatagaaga gcagcattct 748621 cagatagaac ctgggattta attacaagac taatagctga ccccatcaac agagtacgat 748681 cttttgagca agttcgcaaa atgtcttatt tcgcagagat caattttgaa accctaagaa 748741 caagttctcc accatttatt cctcaattag atgatgaaac ggatgcaggt tatttcgatg 748801 acttcacaaa tgaagaagat atggctaaat atgcagatgt cttcaaaaga cagaacaaat 748861 tatctgcaat ggtcgatgac tctgccgttg attccaagct tgttggattt acttttaggc 748921 atagagatgg aaaacaaggt tcaagcggga tactttacaa tggttcagaa cattcagacc 748981 ctttttcaac tttttattaa gattacgtcc ctacaattta attttgtata gcataacaga 749041 tacattgaca acagcaacaa gatgtgctaa cattttccat tttgaatgat taccaaaatt 749101 atgaaaccaa ggcaacatgt aatttttaag tttagtaatc tttttcggga tgagatgttt 749161 tgaagagttt tatgctatta aagtagtaat atgatttata tattcaaata aaatgtaaat 749221 tatgaaagaa aaatacgata agctgatagg gtaaactaga aaccttcgtt ttcttcatca 749281 tccacatcca gtttctttct accgccccca tttcttaagg cagccatctc attagtggca 749341 acttgctttc taaccttctt tgtcatcctg gctatctctt cttcagcgtc aactgcatct 749401 tcttctgcat attgcattac caatctgcgg cccagtaaat ggacaccgtg caactgatcc 749461 atagcatttt ctgcttcctt tggaagtaaa aattccacga acgcaaaacc tcttgcagac 749521 ttgtcgaact tctttggaac tctaacagat tttaattgac caaaagaatt gaataattcg 749581 aaaacgtctt tcctagtagc ttcaaatgga agattcttaa caatgatttt accgcttttc 749641 ttattggatt tagtctttgt attaccgctc tgagatgctt gtctatggga taacttcaat 749701 tgaatcttat ggccgtcgat taccgtccca tccattgcag ctatcacggc attagcttgt 749761 tccttggtcc tgaattctac aaaaccaaac cccattgaca aggtcttgcc ttgatgtttt 749821 ggatcaggtt ttgtcttcac ttgggcaaca acaaaaccag tgaaaacctt gaacctatca 749881 gtaagatttt ggttcgtcgt ggagaagttt agattcttta tgaaaattga gacagttgga 749941 ccatcaataa cgtcttcatc atgagcatta gatgaccctt cagttacatc cttgtttgct 750001 tccattaagt catttgatga aggttttacc tctaccgggt tttcttcttc ttttgcagaa 750061 gtgttattta tcaaatcatc ggcctcagct ggtttagtaa agcaatcctt aggccccctt 750121 tctagatata ttatgccgtc cttaaatctt ttatacgata gtttagtgaa agctgccctt 750181 gctgacgttg tgtccctgaa ttgcactata gctattgtac cagctggtgg catgagcaat 750241 ctttccaatt taccatatgg caaaaacatt tcgccaagct cttctctagt tgtcccaaaa 750301 ggaaaatttt taaccagtat cactttatcg tctctttgat ttgtagattt taactgtgaa 750361 aacttggtca gatcaacacc tttggattca aagtattttc taacatcacc aataacatgg 750421 gcttcagcca aagcttgttt gacagccgaa cttgagtttt cagcatcgat caattgagat 750481 ttttctagac ccaatttggc tgccacacta cccaaaacag catcttggtt catatacaag 750541 gagttccaag aaaatgtttg tctggatgca gctgccttcc ttttcaattc cttttgcttt 750601 ttcaatggca tattctttaa atcaaactca tctaatctat ggcttttttt ttcttcacca 750661 ggaagaatat gcaatagtct tccttgaaaa atctgtttat ccaattcaac ataggcgttc 750721 actgcattct tagaatcctt aaatagaacg tatgcaaatc ctttggattg accagtcctg 750781 gtatccaaag ccacatgaac ctcctctaac tctccaaatg gactaaatag tttcctgaaa 750841 tcttcttctt tggaggtata caagatatta cgtaagaata aacggccagt ttggttaatt 750901 ttttcaatag ccagttcttc gtccgtcttt tgcggcacag cacgttctgg ttgttcttcc 750961 ttcttggtat cgagactttc attttgttca gtagcgtatg atgatgattt ttcccttgtt 751021 tccgcttcac tttctttgat tcttacacgg cgttgtttga accaatctag gtcagaaacc 751081 ttttcatctt gggcgaggtt tctcctcttt tcattctctt tttcatcact attagcgtca 751141 tcattaacta aacctatatc agtatccttc aaattgctaa tacttatcat cttttcttcc 751201 tctccggcat cttcttgatc ttcatccctg tttctgttga gagccgaata ttcatcgtca 751261 ctttcattct caatgaccaa atttggtgct tcgtctttat tattctcttc ctttaaggct 751321 aatgcatgag ccaatagaga attcccttgc acgctggagt cctcttcttc ccgttttagt 751381 ttttcgtcct ctatgctctt gtcaatgcca actttttccc atgatgtgac ttgtgagctt 751441 ggcttcatag tctccatgaa ctcttgtaat tgcttgttct tgcgaatctc gtcatcaatg 751501 ttgctgtgct tattttcatc cactttcttt ttctttcgat tttcttcttg tagcaatttt 751561 tcttcctttt ccctaaacct tttcagagct tctcttctct tctccttcat gggctgcggg 751621 actcttgggt ctgcaaagct tttagccatg gacacttcta tcttagaagt gttgataaaa 751681 ctgccattga aatactctac agcatcaaaa gcgtcttcct cgttacggta tccgataaat 751741 ccaaatcttc tactttctcc gttcctatct ctaagaattt taacatctgt tatgaggtct 751801 ggaccactac cattaactgc ttgatgggaa tgtttttgac gtaatctttt tgtaaaatgc 751861 tccctgagat tatcatctgt tagatagacg ggcaaaccct tgacaatgat acgggacatg 751921 ttagttatgt tatcttgtgc ttgaggctca aattaaatct cagttcaggt tgcagtcttt 751981 gcatatgaag taccgatgag atgagatgag atgagctcta aatttccata aaattttttc 752041 attttataaa attcacgtcg ctccgcacgt aaatccctat tacggaaatt atttctcaat 752101 agggaaagcc cctcctattg ttttttccgt ctcgaggatt tttcactttt agtatataag 752161 taaaacataa aaaacatgag aggtggtatg gtttatttgc cgtcactgtg gagccttcaa 752221 gtaatgtaaa taagagggaa agtgtgatag tacaagatga gttcgaattc aacaccagaa 752281 aaggttactg cagaacacgt tctgtggtat attcccaata agatcggtta tgttcgtgtt 752341 atcaccgccg ccctttcttt tttcgttatg aagaatcatc ctacggcctt tacatggttg 752401 tatagtacat catgtctact ggatgcgcta gacggaacca tggcaagaaa gtacaatcag 752461 gtttccagtc tgggtgccgt tctggacatg gttaccgaca gatccagtac cgctggcttg 752521 atgtgtttcc tttgtgtgca gtatccccaa tggtgcgttt tcttccaatt aatgctgggc 752581 ttggatatta ctagtcacta catgcatatg tatgccagtt taagtgctgg taagacttct 752641 cataaaagtg tgggcgaggg tgagtccaga ttgttacacc tgtactacac gagaagagac 752701 gtactgttca ctatctgtgc gtttaacgaa ctattttatg ctggattgta cttgcagttg 752761 ttctcaaatt ctgcaacctt tggtaaatgg actacaatca taagtttccc tggttacgtg 752821 ttcaagcaga ccgcaaacgt tgtccagcta aaaagggcag ccttgatttt agcagacaac 752881 gatgccaaga atgccaacga gaagaacaag acttactgat aggatgagtt tcttactttt 752941 tttctccttt taattgcgct aatcttttat ttatgtgtag tttttattta tgtgaaatgg 753001 aacattcgtt gatttaactt taaaagcagc ctactctatc gtcttgatta tacttggcac 753061 aacaaatgct caaataaacg aaaaatttca tattgttggt actttttctc aacgcggttt 753121 ttttcctgtt tttttcgagc agttcccgag ggcatattta acataagcca aggagagaga 753181 aaaaacgttt gttggacaga tcaaaaagaa aaagaagaag acctctcctc tatctcaagc 753241 ttctgccccc ccccccggaa ggaattcaag cacgaaggtg aacattgcct acaagaaaaa 753301 atggatgttt tattgtcgct tcctcaaccg gaattattta agaccacggt gattccgttc 753361 ttggcaaatc gcaatataat caagtcggaa gcgattctct ccaacttgca ctcaattttt 753421 tatgttgcta tattctacca tatttggttt ctttttggca aatggatctt attcccacat 753481 ttggttaaat ggaaattgga ctatgaccaa aaacataacg tcaagaaaga tgagaagaca 753541 acttcggaac gtcaagctca acattacaaa aagaagtaca cttctttgat caatcaaagt 753601 tcagtccact taatatccct actgcaaagc atagtggtcc tgtactactc attgaagttc 753661 ttgcttgatc caaaagcctc ggccgagccc taccaaacct cacactctcg agtgtttaca 753721 gaaaatcgag acactcaagt catctgtatt tttgctattg gttatttcgt ctgggatatc 753781 tatatttcca ccatgtattc tactttcccc ttcgttgtgc acggaataat ctccaccgtc 753841 gtgttttgca tcggattgaa accgtacatc caatattacg ccccagtgtt cttgatgttc 753901 gaactttcca atccctcctt gaactttaga tggttcggta tcaaatttct accccagaaa 753961 agcaaattct gctctctact gctgctgttg aacaatttga cgctcatggt cgtcttcttt 754021 gccgctagaa tcgcctgggg gtggtttcaa attggaaaac tatgttacga cttttaccag 754081 gtgcgcaatg aacctggttt cttagtcttt gacaccattg ttatccttgc aggcaatttc 754141 gtcctggaca tcttgaatgt tatttggttt tctaccatgg tgtctgtggc tgcaaaggtc 754201 ttgaagaagg gggagtctgt agacaaagtc actaagaatg aacaataatc catggaggca 754261 cactttaaca tgtgcatata tgtgtatata gactataaac ttgtgtaagc tatgcgagca 754321 ttacaaacct agaaaattac aggcaataaa tcaatattga tacatggcga atttttgtgg 754381 ggggggggca ggatctttgc ctacattttc ttctttaatt ttacctagac tgagcgattc 754441 tgccaccttc aggactactg aacactttca atgctacttt tgccagaatt atactatact 754501 accacacttt catgtgatga aacgtgaaac tctaatcacg agatttaggg ggaggtgttt 754561 catatgcgga taacgccgtt ctcgcgcaag ctgattttcc attgcttaat aaaaaggcga 754621 aaagcctcct acatagagga tgatgttggt ttgaccgtga ttgatgtcca agtagctgtg 754681 gcttattggg tattctttcg gaagcttttg tgattttttt gttaaggttt gagagtggtt 754741 aattgagcca aatacggcgc ggtacaggta aagagagaag aatcataaag aaagctgttt 754801 tctttatcct agtctacttt ttatggcttt gtgtgctaaa agaagaaaaa caagagataa 754861 ttaagtggat taatagatgt ctgactattt cacgtttcct aagcaggaga atggcggtat 754921 ctcgaagcag cctgcgacac caggttcaac tcggagctct tctagaaatt tggagttacc 754981 gaagaactat cgttcatttg gtggtagtag cgatgaactg gcatctatgt attccgccga 755041 ctcccagtac ttgatggata tgattcctga ttcattgacg ctgaaaaatg agccagcatc 755101 tggaaatacg caaatgaacg ggccagatgg caaagagaat aaggacataa aacttgacga 755161 gtatatatta cccaagacag acccaaggtc accctactat attaacatgc ctatacctaa 755221 aaaattgccg aagagtgaag gtaaggcgag ggctaaacaa aaggttaaca gggctgatcc 755281 ttctgattta gatgtggaga acatttacga aacttccggg gagtttgtta gagagtatcc 755341 gacagatatt ttgattgata ggtttcacaa atggaagaaa atcttgaaaa gtttgatcgc 755401 ttacttcaga gaagctgcct actctcagga acaaattgca aggatcaact accagatgaa 755461 aaatgccgta aaatttgctt ttcttactga tttggaagat gaaacaaaca aactggttga 755521 tccaagtata tctaagttgc ctactaagaa acctcagcct gtcccattgg ccgctcaaaa 755581 attggacagc aagtacgaca cagatgtgga acagccgcag tcaatccaat cagtaccttc 755641 ggaagaggta gcttcagctt cttctggctt catgaaattt gggtcaggat ccattcaaga 755701 tattcaagtg attttgaaga agtaccattt atctttgggt agtcaacaat ataagatctc 755761 taaggaaatc ttggcatata ttatacccaa attgaccgac ttgcgtaagg atttgaccac 755821 aaagatgaaa gaaattaaag aattaaatgg agatttcaag actaacatag gcgagcatat 755881 caaaataaca agcaggcttc tgaataaata tattgcttca gtgaagttat tagatgaagc 755941 atccacttcg ggcgataagc aaggtgaaaa attaaaacca aaacacgatc catacctttt 756001 gaaattacaa ctagatttgc agctgaaaag acaattactc gaagaaaact atcttcgaga 756061 agcttttctg aatttacaat cagcagcact acaactggag aaaatagtat attctaaaat 756121 tcaatccgca ttacagcgct actcagcgtt aattgattca gaagcacgat taatgatcaa 756181 aaatttgtgc catgaattgc agcaaggtat tctatctaga ccaccggctg tagagtggga 756241 taattttgtc tctcatcatc ctacctgtct gatgaattta aaatcgacag acccgccacc 756301 gcaacccaga agattatctg atattgttta tcctaacatg aaatcgccgc tggccaaatg 756361 cattagagta ggatatctac tgaagaaaac agagtcttct aaaagtttta ctaaaggtta 756421 ttttgtgttg actacaaatt atcttcacga attcaaaagc agcgatttct ttctagacag 756481 caagtctccc cgttcaaaaa ataaacctgt tgttgaacaa tcagacatta gccgtgtgaa 756541 taaggatggg actaacgctg gcagtcaccc atcgagcaaa gggacacagg atccgaaact 756601 gacgaagaga agaaagggtt tgagttcttc gaatctatat cctatctcta gtttgtcttt 756661 aaatgattgc tcattaaagg atagtactga ctcaactttt gttttacaag ggtatgctag 756721 ttatcattca ccagaggaca catgtacaaa agaatcaagc acgacctcag atttggcatg 756781 tccaacaaag acgcttgctt caaataaggg caaacatcaa cgtacgcctt cagctctctc 756841 gatggtgtcc gttccgaaat ttctaaagag ttcttccgtg cccaaggaac aaaaaaaggc 756901 taaagaagaa gctaacatca ataagaagtc aatttgcgag aagcgcgttg aatggacgtt 756961 taaaatattt tccgcaagtc ttgaaccaac tccagaggaa tcaaaaaatt tcaagaaatg 757021 ggttcaggac ataaaagcgc ttacaagttt caattctact caggagaggt cgaacttcat 757081 tgaagaaaag attctgaaaa gtagaaacca taataatgga aagagctctc aaaggtccaa 757141 aaacagtaca tatatcactc cagtagacag ttttgttaac ctttctgaaa aagtaacgcc 757201 atcttcctct gttaccacgt taaacactag gaagagggca aatcgtcctc gttatataga 757261 catcccaaaa agcgcaaata tgaatgcagg cgctatgaat tccgtataca ggtcaaaagt 757321 caatacacca gccattgatg aaaatggtaa tctggccata gtgggagaaa cgaaaaacag 757381 tgctccacaa aatggtatga gttacacaat tagaacccct tgcaaatcgc cttattcacc 757441 ttatactggg gaaggtatgc tttacaaccg gtcagcagat aacttaatgg catcctcttc 757501 gcgaaaagca tcggctcccg gagaggtacc tcaaatagct gttagtaatc atggggatga 757561 agccattatt ccggcaagcg cgtattcaga tagtagtcat aaatcgtctc gtgcctccag 757621 tgttgcatcc attcacaacc aacgggttga tttttatcct tcgccattaa tgaacttacc 757681 aggtgtttca cccagttgtc tagcattgga tggtaatgca aacggatatt ttggaatacc 757741 attgaattgc aattcggaag caagacgagg gtcagatctt tcaccttttg agatggagtc 757801 tccattgttc gaggaaaaca gaactcaaaa ctgcagtggc tctcgcaaaa gttcagcttg 757861 tcatattccc catcaatgtg gtccaaggaa agaaggtaat gactcacgat tgatctacgg 757921 caatgagaag ggcgcctcac aatcacgtct aacgttgaag gaaccgctta catctaaagg 757981 tgttgaagct ccttatagca gtttgaaaaa gacatatagt gcggaaaacg tcccactaac 758041 atctactgta tcgaatgata agtctcttca ctcgcgcaag gagggaagta ctaatactgt 758101 acctgctaca tccgcgtcaa gtaagtgaca ctatgaaaac ctgtccaata agactgcaca 758161 gatgaagagc atgtcatttg gttccttgat aagtgtaata agcaacaaga aagtcctggg 758221 tcatgttcct gctgaaaata caaacccatt aactaccgga aacgaagaag attaagacaa 758281 aatggaaaag ttaagttaaa cgcaatcagt tcatatattc ttagatagtt atcatgtttt 758341 tataagtaaa caaagtagtc ttctaccaaa taaaaataga ttcctgattg ggtatttttc 758401 agaagtatca tctgaacttg atgttatttt aaaatgaaag ccagcgtcca taattatctt 758461 tttcttactt gttttttaca gtggcggtag gattggcaat gcctgttcat ctccagtttt 758521 ccggtccgct tacgacatcg gcctttctat aagacaggtt ggcaatgcgc cacggtacat 758581 gatgacgata ggagccttcg aataatattt tgttgtgaat tctcctggga acctctcaaa 758641 atcaaatatg ggtttaccta aatcggcata taagaagtta ctcatagatt gtccaacgag 758701 agtcattaat aaaaactgtg cccaacgagt caaagatgtt tctccgctca ttacaaactt 758761 cgagaaatgg tcggataagc gcaagaagct ctatttcaaa gatgaagagg aaatggtggg 758821 gcagttccat ttggaaaatt tcaatttaaa aaataactta tatggtaggc ttttagcttc 758881 tccaatgaga gcagaaaaaa tctcaaaatt aaaatcgtgt agagaattac taattccatt 758941 gaaagtggta ccatcaactg gcaaagatca gcatgctgat aaagataaac taaaactggt 759001 acctacacta gattattcca aatcatacaa aagctcgtac gtattgaatt cagcctccat 759061 tgtacaagac aacttggcgg ctgcgacgtc atggttccca atctcggtat tgcaaacatc 759121 aactccaaag agcctagaag ttgattcctc tacatttata acggaataca atgctaactt 759181 gcacgcattt ataaaagcaa gactttcagt gataccgaat gttggacctt cttcgataaa 759241 tcgtgtttta ctcatttgtg acaagagaaa aacacccccg attgaaatac aagtagttag 759301 tcatggtaaa gggctaccaa ttacacagtc tgtctttaac cttggttatc tccacgagcc 759361 aactctagaa gctatcgtga gtaaagatgc agttactaat ggaatttacc tggatgccga 759421 caatgacaag gatctcatca aacaccttta tagtacatta ttgtttcatt cagttaactg 759481 attgcggaag aaaaaaggaa ggaaagcggg atatatcgct ggaattgtct ctctgaattt 759541 gccattattc ttattcaatg aatacaaaac tggctgtcag cgaatggcat cattttgcaa 759601 tccgaaaatg aaaaatttgg gcgcctcggg caggagaatt cagaaccctt aatcccgcac 759661 atctacgtaa aatatctctg aggtgttcta tagtccatca cttaccatcc atctgcaagg 759721 ctgtatgatt gataaagagg aacattaagg gtaaatagat ttgttgattt gtttgcacta 759781 gtggctttgt attaaaaact tcaagggcat acacatgcat tatattcaag agcacaacca 759841 ataatttacc attatagaag gtacttcttt gaaaactaaa tcatacactt tttcccacga 759901 aaaggcttac atttaaaagc taagcattca atttagtttt gctgatcaat ttctcgagta 759961 ggcttgtcat ccataatatc tagtagctgg agtatcctgt ttattgcaag aaaaaaaatc 760021 tacaatgtct atgttaccgt ggtctcaaat aagggatgtg tctaaactat tattaggctt 760081 tatgcttttt attatatcaa ttcagaaaat cgctagtatt ctcatgtcat ggatattgat 760141 gctgcgccat tccacaatac gaaaaatttc atttggatac ttttttggta cgtcaataag 760201 acgagcgttt atcttaactg attttgctca aatatatatt ggcaagataa ccttgcgaat 760261 aggttggaaa cccggaattg tgtttcataa tgttgatttg aagttatttg ggaaggacag 760321 ccatatcact gcacattcaa ctaaagactc cagaacatat ttcaatccgc gggatcaaac 760381 ttttaccttt gtaattaaca ggcgagtcct atcaattttg aaacttgtgt tctcattttc 760441 cactttcttt catactttag ctcttacagt gcctaatgga aaacaatata aattaaatat 760501 cggatccata acgatatcac acccacacga tgataccata aagttagagg catttttgca 760561 tgattttacc catcctgaaa cgaaagatac tttgaaccat actggttttt ttatggtctg 760621 taaaattgga aaggaagatg atacaggcag caactgcaca aaagttatac taaaaaattg 760681 gaaatcaagt ctcaaaataa gtgatgtttg ttggcatctt ccagagaaga aagggaagaa 760741 tttgcattcg gagcctgttg agcctttttc tgctggtgat gatgcggaaa tgctcacttc 760801 atatcgtaag atgctaaagc cttttcacta cccactgaaa actttgaaca ttctggacct 760861 taaggtagaa aatgtaaagt tgatttacaa aaaaaagttt acaattcgca tatcaagtgc 760921 tcaactttac ttggaatcaa tctccattct aaataatgtc tccgctttgg aacttttacc 760981 cttaaataag cccacatggg gcgattttga actatcactt tctgcaaatg ctgttgtagt 761041 agatatcgat ggtaatacag cagttagaat tccatttgga aatgtcatac tgacgtcaga 761101 tattttacta tttttacttg acaatgtacc tttacggaga acgaaggtat cttccatttt 761161 gaacattata aatccttcag tattcctcac tatacatcaa gtactggaag ttcttcattt 761221 agtggacaaa ttcgatagcc ctgagacctc atcatgtact aacacaaacg acagatcatt 761281 aaatatttta gatttagata ttgatcgatt gcccagtttt aactttgaac tactaatgtc 761341 gaattttatt tcaaggctgc atatatcaga tgaggagaat gtgacgttta aggtcttcag 761401 cacacatgct ctctttagcc gtaacaactt gtctatgact cctaaaaagg gacaagtaat 761461 gcaaatacgt ccggattggc catttgcgaa gacagcccta gtatctgatc aattatctaa 761521 ctatattaaa attgtgggta catcactctc ttacctgaga attccaacag agcaggacgc 761581 taacccagtg tctataccag tctgtggctt tgaaagatta gacacatttc tggatgaatt 761641 ttcaaattct aaattgatcg ttcagtctac actaagacat tcgtacgtta gtcttgagaa 761701 cattgaagtt ttgcatactt taagtcgcgc ctttgacaaa atttacttgc taatatctag 761761 cagaacaaaa aggaatgcgg ctcataaagc gaatggtgga aaattggggg acctaaatga 761821 agccaagaaa acatttaact ggtcattgaa acttagaatg aaggatattt catgttcgtt 761881 actggtcgct gggtttcttc cgaaaaattt ggatcctgtg gaagctgaga attttaactt 761941 atctgacgta actagaggcg ccaaagttgt ttttacagaa tcaatattgt tagcggacag 762001 ccaggagaaa aacttcacta ttattgatgc atccgtatat cgtttcatgg atggcactac 762061 gtataagccc tctcctgagg ttattattca atttaccaat ttgttattga gttttaacga 762121 ctcagatgaa attcattttt cacttcccaa gattaaattt aagatggatg taaatattat 762181 ctggttgtgg ttttatattc ggagtatatg gataaaattt cgtcctaatt caaaattgag 762241 ccgaaattca gtgagcagtg taaaatctgt caatgttctc gatagattaa gagtagatat 762301 aggaaagatg attatagagc taacgcttcc tcataataca gaggtactcc taatattcga 762361 gaggattgga ctttcaagtt ccactaaaaa tcttacaatt gcatctttgt cagcgtacgt 762421 ggtatcggtt tatgtgaagc atattaaggt ttatgtttcc ttgctaaata ttaatgactt 762481 tgagctagac actgaagagt tgatctgcaa gaaatccgct gttataaaca cctcattgat 762541 tcattttcat gccgaatatc attttagatt ttacatgata acggataaca tagtcacgtt 762601 gtataaatcg tttaagcaaa ttaaattggc attttccaat ttgaatgaat ttaagcgatt 762661 ataccctcag caacagtttc cgaaaaaagt tccaaattta catatttgtt gccaggattt 762721 tctaattgat attgaagaag atccttttga gcaggagtta ggattaattt tgaaagttgg 762781 tgttttggaa caacgtgaga ggttaaagaa gcttgaagag ttcaaggaaa agctatcaac 762841 atatgaggac atgaatgtac gtttaaggtc gctctatgat acctcccgtg gacaaagttt 762901 tttcccagag ttttatgcga atgatcaaga atatgagcaa aaggcctatc tcaggttgtt 762961 agaaaacttt tcaacgtcat ggattgccag atacaggaaa gcaaaacttt ctttttatgg 763021 tatgccttat cgggttatca gccgtgaaga gcttggtacg aaataccact tgtttactag 763081 acagaaaacc agtactgttg ctaacctcgt cgtaaaagat ttggatttta aactaggcag 763141 tccttccttc cctttagaca attatatgga ttttgtttac cagtatggaa aaaaagttcc 763201 aaaatctacg gagtacactt tgctaattat tcttggcctc aaaatcaaaa gcgcgttatg 763261 ggagttgcgt ctgagagatt atccaatacc tgctatatca tttcccgaca catttacaac 763321 aggtgatgtt gtatttgctg aaaagatgcc agcaccttgc gcgcttcata ctgtttatgt 763381 tccttttgtc agctctgccc aaagaagccc ctataatgac gccaatacaa tatatggttt 763441 gcacatcatt cgtacaatta attcagtcaa aacatatttc aatattaggt caatggttac 763501 atcttcttca tctgccagaa taacatgggg gaaatctctg caacccggtt atgagtcttt 763561 gatgctttgg tttgattttt taaccaaacc tctcatcgat ccgtccaaaa agctaggatt 763621 ttgggacaaa ttcagatatt tagtgcatgg gaagtggata tacgagtttt cagaggaaag 763681 tgagatccac ttaaatatta aaggttcaca tgatccttat aagattacag atgatggtgc 763741 gggtctggcg ttctgctggt ctggtggcac cacaatttac gttcataact ccacggatcc 763801 taaagagttt ttaaaaattg aatcccaaag gtttcagttg gcagtgccag actttgccaa 763861 agttagtaaa tttgataaag tctttatgaa gctcgatgga agagtaattt ggacattagg 763921 tttacttttt gaacaaggcg atatatctaa ggctggtgac gaagagaggt tccttccaaa 763981 taggccacat tatgaaatac agctgatgaa tccagatgga gtcgcagatt tggatcacca 764041 tgatacatac aaaggattta gaacatcttt tatccacatg tcatttggtg tctattcttc 764101 tgagcacgga tccataaata gtctctatct cgcaccttac gctttaacac atttctttaa 764161 gtggtggaat ttatttcata catatacatc tggtcctatt aggcaaggac ggttatttac 764221 ggatgtactt caaaacaaga caaagtttgg tcgctcatta tttacaatag cttatcagct 764281 acatttaaaa cggctaatgg ttacgcatat ttatcggcat attactactc aatatgatct 764341 tgaaaaagac cgcaaaataa cttttactgg attgaaaggg aggtttgatt cactgaaaat 764401 tgatttgcat caaaaaagag ttaaactgac ccatacgaac caaaaattaa ataagtcaaa 764461 acctgtatgg aagtttaaga tgtctagggg tgagattgat tgtgcagaag cagatattag 764521 gatattatca actctgtttg atcaggaagc agttaaggaa attcttactt ctggactcga 764581 tggcatactt gaagacgagc catcacgtcc tattacgcct caagatgtgg aatacttgcg 764641 tgaatcagat tggtatgatt atgaggatta tatagacttg aatcaagtgc cgcttggttc 764701 ctcacttcca ttaaaattag aagcaatacc attgctatac tctcctagaa tatcctactt 764761 tagaaaaata aatgatgatg gttacgtact agcttaccca tttggtaccg aagaatctca 764821 caattgtctg attggcaaga atcatccaga attgacgcag gagaaattag caactgaaag 764881 aaaacgagaa atagaagaac aactaaaatt attacatatt acgttaagcg aattgcaatc 764941 gaacaaaggc ggaggttcgg taagtggaaa ttcggagcgc tatgcacgcg aattaaaagc 765001 agaggtagct gaattaaacc acagattgca cacagtcaac accatcttga gcgatttaaa 765061 aatctcggag actattcctg gaggaaatac tgatggtgat agctccagct cactctccga 765121 tactgatgta aatttggaaa atgcaccgcc aattcaaaat agaatatcgc tattgaggac 765181 caataccgtg gagtcttttg tatcaatgag aaaagcctct actatgcagg ttgagtccac 765241 ctatgataac cgtttcatgg tccataatat cgagttaaaa atcgataata aaatcaggca 765301 tcaccttttg gaatacgctt ccagtgcttt cgaaaggaaa tctatgaggt ttgctgtgac 765361 ttataaatcc gtaactattt taaaagaatt actgggaaat gtgttgactg gggtcagaac 765421 atctgtagaa gattatggtt caatacttga ggacgattta gccagtaatt cagaatttat 765481 tgagcacttt gagaaactca tcagagaagt tccgagtgat gactttgatt atgttgataa 765541 ttatcttttt agactaatct cccctcaggt tcagatcaaa tcggacgttg aaaggaacgc 765601 agcagttatt ttagctgcta gggatataga aatgggaata attgatatag ttcaagtgta 765661 tggaaaatca ggaaaaagaa ttcccgttga cgtcgatact attgttgaaa ctcgctattc 765721 cgctgtttca aaggacattc agttgtttac attgttcaaa aaggatttag agggtcctga 765781 aggtagattt ttccataaaa atggatatgg ttccgacaaa gagtcagata tatggccccc 765841 atggattcct cttgaaatgt gctttgacgg gtctttatta gataagcatg tttttctaaa 765901 acggagatca atgtttttga cctacgtcgc tcccaatccc ctatttttta gtgcaaatga 765961 tacgtctgca ttctcttatg attcgagatt tcgtattgca tttccaggat tggttctgac 766021 ctcggactgt caacaatact gcgctgtata tgcaatcgca gaagatttac tttcctttgg 766081 atcatcattg gatgaaaaag ttgagaaact ttccaggata ttatttactg atgaggtcag 766141 aaataacctg gaaaatcttg atgtctctgt tgtcacagca ttacaagaaa gaataaagga 766201 actctattat acgcgagcat acctcaaact tcacgagcca agattgttta tgaaatcagg 766261 acaagagcta accttcgata ttcaaactag tacgttgaag ttgacgttac ttatgacggc 766321 aatcaagaaa acttacgacc ggatggggag tggtaataga gtaatacaga aaagattgag 766381 gtggcaagtt ggaacagatg aattgatatg ggaattgtac gatgagagta aaactccttt 766441 cgtgactatc ggattggggc cctctacatt tattcgttca gaaacttccg atggcactaa 766501 tagtaataaa gtatccattt cttccttaca atgtttcaac cagcaagaaa atcccgttta 766561 cactgaattg ctggccccct tttatgaaaa ttcatcctat aataagaacg cgccaatggt 766621 agaaattttt tggatcctgg ggccatcagt tggaggtatt tcagatctgc aagatttgat 766681 tgtttctcta cagccattga ttttcaagat ggatcacaaa acatcggaaa aactaatgaa 766741 ttatctattt ccaaagatag aacaaacttc catagaaccc aattctccag aacttgtacc 766801 acgttcttcc actagttcct tcttttcatc gtctccagtt ttacggcaca gtctttctaa 766861 cggttcttta tctgtgtacg atgcgaaaga cgttgactct tgggacttgc gtagtatcca 766921 gagcaaagaa ggtatcaaaa agcataaggg tgatcataga aaattgtcag catcactttt 766981 tgtgcaacct gattataaca tcaatgaaat ggtcaaaaga tcagggacat ttttcaatgt 767041 aaaatctatt ataatccgaa aaactctaat gtccgtgtgt tataagggtt cacacagcct 767101 tttgaccgat gttaataacc tgattgttag agtccctgtt ttaaagtacc ataacaaact 767161 gtggtcgagg gaagaatttt ttactgcttt gaaaagagac gtcgtaagaa tagttttaca 767221 acatttggga aatattattg gtaacaaatt tttgcctcat aaaaaagaga ataagaaaaa 767281 aacttctatg gaaatacatc gattactaag tccagattct caaaatcgtg ataattcaca 767341 tatccttgaa gtcgaagggc ataattcatt ttatagctcc acgcactctt cagatatcag 767401 atcaataaac tcagatgaaa cgtataatga aaatgatgga aatggagtaa agccatttta 767461 ccctgttacg agtgagtttt caaaaaataa atgaggaaac acacacatgt gtctagcgta 767521 aatattcttc agttatatag taattgtatt atatactaaa atgaaaatca gtaagatttt 767581 ttttttacag gccttcttgg cgttagtttt tccggttttt cacttactaa gatgagatga 767641 tggggcgcac ggccaaagta ttccccattc atcaatttag catgctagaa taaaaagatt 767701 aagagcaata tctacgaccg acaaagtgat ctatcaaact gctgacaaaa aatgtcgttg 767761 gaagccatcg tctttgatag atcggagcca gaaaatgttt cggtaaaggt acttgatcaa 767821 ttacttttac catatactac taaatacgtt ccaattcaca caattgatga tgggtactca 767881 gtcatcaaaa gtatgcaggt gagaggtgcc ccggcaattg caattgtggg ttcgttatct 767941 gttttgactg aggtacaatt aataaaacac aacccaactt ctgatgttgc tacgctgtat 768001 tctttagtta actgggaatc tacaaaaaca gtgctaaata agaggctaga tttccttttg 768061 agtagtagac ccacagccgt taatttatca aattctcttg tagagataaa gaacatactg 768121 aaatcctcaa gtgacctaaa ggcttttgac ggtagtttat ataattacgt ctgtgaattg 768181 atagatgagg atttggcgaa taacatgaaa atgggtgata atggagctaa gtatttgatt 768241 gacgtgttac aaaaggacgg tttcaaggac gaatttgccg ttctgacgat ttgtaatact 768301 ggatccttag caacctctgg atatggcacg gctttaggtg ttatccgttc tttgtggaag 768361 gattcacttg ctaaaaccga caaggcagac tcgggattgg acaatgaaaa atgcccgagg 768421 atgggccatg tcttcccact ggaaactaga ccttataatc aagggtcaag gctaacagca 768481 tacgagctag tttatgataa gattccatca actttaatta ctgatagttc catcgcgtat 768541 agaattagaa ctagtccaat tccaatcaaa gcagcatttg ttggagctga tagaattgtt 768601 cgtaatgggg atacagcaaa taaaattggt actttacaac ttgctgtaat ttgtaagcag 768661 ttcggaatta agttttttgt agtagctccc aaaacaacta tcgataatgt aaccgaaact 768721 ggcgatgaca ttattgtgga agaacgtaac cctgaggaat tcaaggttgt tactggtaca 768781 gtaattaatc ctgaaaatgg ttccttgata ttgaatgagt caggagagcc aatcactgga 768841 aaggtcggta ttgcccctct tgaaatcaat gtctggaatc cagccttcga cattactcca 768901 catgagctta ttgacggaat tatcacagaa gaaggtgtat ttaccaaaaa ttccagtggt 768961 gaatttcaac tggaaagcct tttctagata tcattctaat tagactctcg aaataattac 769021 ttttgtactg taaaggataa aatttcatat tgagatgtaa gaattatttt tttttttcat 769081 tcaataaaag gaacacatta atgtatattg tcagaacctt gtaagtccaa aacactataa 769141 ccaactgata caatatgtat tgtctttgtt tctgcatatt tgtaaaacgt gcaaaaaagt 769201 aaagaactcc tcataggggg ctcgaacccc tgacatttcg gtatccttgc ttaagcaaat 769261 gcgcttaaaa gccgaacgct ctaccaactg agctaacaag gatgagttct tcggagcgtg 769321 ttgtatctca aaatgagata tgtcagtatg acaatacgtc atcctgaacg ttcataaaac 769381 acatatgaaa caaccttata acaaaacgaa caacatgaga caaaacccgt ccttccctag 769441 ctgaactacc caaaagtata aatgcctgaa caattagttt agatccgaga ttccgcgttt 769501 ccaccactta gtatgattca tattttatat agtatataag ataagtaaca ttccgtgaat 769561 taatctgata aactgtttta acaactggtt acttccctaa gactgtttat attaggattg 769621 tcaagacact ccggtattac tcgagcccgt aatacaacag agcgtcctta ataaatattt 769681 ctataaatat ttgatgttta ccttccgaaa aaggtacatt gccaacctta tttgataaat 769741 gtgtaaacta agataagtgt tgagatcgga ttttgataaa ggcatttgtt tggggtgtat 769801 gagttgggaa aagaaacaac aatcatctct tgaccagttt tcctactact agtgtgttat 769861 catatagcgt aagagtatga catagagatt gagaaacaga aactgaatca taacgaacat 769921 cacagaattt acatttctac acaattttca gaaaaagtgg agtggtgata tatgcttatt 769981 gttctacaag ttctcttcat gcgtttttgt ttatctatct tattgaatta ttatcttcat 770041 gcatttatac ttattaaatt cgatgaacat ttcatattat ttttatatgc ttcataattc 770101 atgttactac gatctataca gagtattatc gtaatgtctt acctttagct tgtcacttaa 770161 cacatgcact gcatttcgaa aagatgctta agcaagttta tcataatttg ggagtgttcg 770221 gtgaatttat acagaaagcc cctccaacgt cttattgata atgtatattt agttcattta 770281 ccaaaatact atcaattcat caacctccaa gtggttttga ctaaacagcc cacaattgac 770341 atatgtgact gctaagcaga cctttcttga agtaaatttc agggaaacta agctacggcc 770401 tttccaaaat atgggcagga actgcttaat cctttccttt tattagataa gcactttagt 770461 atttttgttt ttcatggcct tatcctacgt tattgtcgtg aaagaaatgg cagaaatttc 770521 tgttgtacat aaattactaa ctgccttacc ttgaaaacgg ttttattaca aaaatagggg 770581 tcaagtgttt tgttatccct gttgttgttg ttttataagt cctaatctcg cttgaatatc 770641 gcccatattc acaccctgtt cttgaccgtc tactaaggtg ccttaggggg actcaaactt 770701 aagatcgcct tctacgcgtt ttatgctatg atcattagtg ttgatgcatc ggaagtttaa 770761 aaattaagtg cgagtgcatt agcacagtgg aattattaga atgaccacta ctccttctaa 770821 tcaaacacgc ggaaatagcc gccaaaagac agattttatt ccaaatgcgg gtaactattt 770881 gtataatatg tttacatatt gagcccgttt aggaaagtgc aagttcaagg cactaatcaa 770941 aaaaggagat ttgtaaatat agcgaccgaa tcaggaaaag gtcaacaacg aagttcgcga 771001 tatggatgaa cttcggtgcc tgtccctcga ggaaatagca aactcgttac agctagcatc 771061 tcatagcatg ggcatagagt ttcagaaatt ttgctcttaa tggaaaatat aacctctttg 771121 gggaaaagag aaatagatcc tttctcaaaa atttagaaag gaaaaaaaat caaaatataa 771181 taaaatagat tttttttagg ttaatttttt gccaatttag ctagactttt gaaaagatcc 771241 aaaaatttac taaaattgaa tctttctggt attaattttg tcctatacct caagaagtaa 771301 agtattctcg aattgatact tctgaaaagc gaaagaaata tagctaaagg atactggtta 771361 tttattcttt ctttttttct ttctttttga ttgagccagt gtataataaa aacctactgc 771421 gagctattca ataaattgac atagaatatc tgttgaagcg gttctttgat tgagcatctg 771481 ttttcctttt gtatttttgt ccttttagat tcttttaacg acattggaga aattttaatc 771541 attgtataaa aacttcattc gctcgtttgt cagaagtttt tttataactt gctatttcct 771601 tccaagaagc cttttattga ttaccccctc tctctcttca ttgatcttat agatgtccaa 771661 cccaatagaa aacacagaaa actcacagaa tactagttca tcaaggtttt tgaggaatgt 771721 acaaaggttg gccttaaaca atgtaacaaa tacgacattt caaaagagta atgcgaataa 771781 tccagcccta acaaatttca aatctacact aaactcagta aagaaggagg gaagtcggat 771841 tcctcaattt actagagaaa gcgtatcaag atcaacagcc gcacaagagg agaaaagaac 771901 cctgaaagaa aatggtatcc aactccccaa aaacaatctt ttagatgata aagaaaacca 771961 agacccaagt agtcagcaat ttggtgcgct aacttctata aaggagggga gagctgagct 772021 gcctgcaaat ataagtttac aagaatcctc ctcagcgaag gagataatcc agcatgatcc 772081 cctaaaaggc gttggatcaa gcactgaggt agtccataac tcggtagaaa acgaaaaact 772141 tcatccagct agaagtcaac ttcaagttag aaataccgaa agtgaaactg atagtggaaa 772201 aaaaagacca atttctacaa ttgttgaaca agaactgccc aaaaagttta aagtgtgcga 772261 tgaaaatggc aaagaagaat atgaatggga agacctagat gcagaagatg taaatgatcc 772321 attcatggtc agcgagtacg tcaatgatat attcgaatat ctccaccaac tagaggtcat 772381 tactcttcca aagaaggaag atctctatca gcatagaaat attcatcaaa atcgagatat 772441 cctagttaat tggttggtta aaatccataa taaattcggc ttattaccgg agactttgta 772501 tcttgccatt aacataatgg acaggttttt aggtaaagag ctagttcaac tggataagtt 772561 acaattggtt ggcacatcat gccttttcat tgcctctaaa tatgaagagg tctattctcc 772621 tagtataaaa catttcgcat cagagacaga cggtgcatgt acggaagatg aaatcaaaga 772681 aggggagaaa ttcattttaa agacattgaa atttaaccta aattatccca atccgatgaa 772741 ttttctgaga agaatttcga aagcagatga ctacgatata cagtctcgaa ctcttgccaa 772801 attcttatta gagatatcat tggtagattt cagatttatt gggatactac cctcattgtg 772861 tgcagcagct gcgatgttta tgtcgagaaa aatgttaggt aaaggtaaat gggatggaaa 772921 tctaatacac tatagcggcg ggtatactaa agaagaactt gcgcccgtgt gtcacatgat 772981 aatggattat ctagtgagtc caattgttca tgatgaattt catagaaaat atcaatctag 773041 aagatttatg aaagcttcta taatttccgt ccaatgggct ttaaaggtta gaaaaaacgg 773101 ctatgatata atgaccttgc atgaatgaga agaggggcag atgcttaaaa tatctaaaac 773161 gataatcgat aaatgtccat ataaaatgta tggctgcttt ttaatcattt cttttcacat 773221 ttccatttat tcttacaaat ttcacaccca attttagcgc ctttcattct gttattttta 773281 aactgacgat aaaaaatcat tcgaagccta agatttccaa aataaaactc catttttatt 773341 ctcactaata acaccacacc attaatttta attttttaat tttaatttca gatttgtacc 773401 ataagtttta ttctatttca gttcaaccgt ttccggatgc atgtagcgag ggtagacaaa 773461 gaaaagcatc agtatcggat gttgatatta tgggaaatat cataacctta gtctcttaaa 773521 aaatgctgct ttcttctcat ttttcatttc ttttaaaatt atttcagtat agttattata 773581 attaacattg gaataacatt aataataata attttttaat agtaataatg ataataataa 773641 taataaaaat aaaagaataa atttaaaaac aaaaaaaatt ctaatattaa tgatgataat 773701 agtagtaata ctggtggtat tatatatgtt gaagtgaaca cgcatatcac tataaactat 773761 atatacatat atatagatag atagatagat gcaaaaaatt ttttcctttt agttcagcaa 773821 aaagaaaaga aaatgtaaag agtatgcgaa ttcatgagca ttactagtac taatctactt 773881 aagattaaat agattttgaa agttgctatg catttcggat gtacaccact tgaaagtttg 773941 gaaataaaca gagccatacc ttggtttctt gtacttcaaa atcaatgaat ctaaatgagt 774001 tttggaacta gcgatgtctt tgactagatc aatgcagaga gactgaaacg cttcatcgtg 774061 tattggatcg ataccaccac tgtaatgctg tagtgttcca ttccatagct cgttcttgtt 774121 tctgttggtc attcttctcg ctatatacat tgccattgcg cttacggtag atggaggtaa 774181 atgaatgaat tggtggcagc agtaggcata ctctaaaata aacttaccaa tatttctatt 774241 aaccggatcg taatcatctg ccttggagat cctccttagg aaattgagtg ggttgggcca 774301 accaatgttg aattctaagg aagtgagcat gaacatttcc gcatttttta tgtcgttttt 774361 agaagccgcg ccgtcagtga tataagcgta ttcagctagt ttgggcaaat ttacctcttc 774421 aaattttgcc gcgatgaaaa gtgaggtaac tgccaataat tgtaacttgt tcatcgtaac 774481 tttattttta gctaaaaatc tatccattaa gtttatggat aggaataacg tttccggata 774541 gcattgaaat ttttcgtgca cctctaccag ccaatccact aatattgttc tcatggaagg 774601 cctcaaataa tacttggacg ttttgtcgag taaatagttg tgcgatggta acgtttctaa 774661 ttctcttcta tataaaaatg caaaaatttc agcagaatat tctgctacca ttgcagtatc 774721 atctttttca acataatcta ggtcctgcca gcctactatt tcactcactc cttcagcgtc 774781 tattctgcgt tttttgttca ctatcgaagc agcatcatca tcttctcctt cttcttcttc 774841 ttcttcttct tgctctgctg ccgttcgatc gttatatatc tgtctttttt gaacggcgct 774901 aacaataggt ctaatgtttt cttctcttcg tactttggcc gccttgctcc ctgctactat 774961 tctcttgttc tggcttaaag gattattgtt cactggtaca tctgttaaag cccttcttgg 775021 tttagaatcc tgaacctgct gcttactaga gctgtcattt tttgaaaggg cccttttatt 775081 ttgaagaatc tttaggtttg aattgcacaa ctgcctctca ttttcattat aaatcataga 775141 atttctttta atactctgct catggtcgtg gttctctccc attgttcagt aaaggtgttc 775201 agcggcttta aatacaggga aaagcgcgtt actgctaatt attaagctta ttttgctttg 775261 tgtgagacaa ctaattggcc gtgaaaagct ttaggtgatt gagtctcttg aagtacaaag 775321 acaaaaagac ttcaatagat agacagaaaa aaaacttttc ttgagaagct taagaattag 775381 ttccaagtag cttctaataa accgatgaac gcaaatgaag ttcccttcgc ggtagatggc 775441 agtagctatc ggcagtcact aggaaaagtg agtttagcac agatatgctg tgggcgctat 775501 cccaatgtgg gcaaagcgcg tgaacatcac gacgcgcctt cccgttaaat tttgtaccat 775561 caagggcgcg tcttcactcg agatgcgcgt tcttttgctg gttcttttca ctgagggcac 775621 agaatatgat acccacagta tgacaagttt taatcgagat agtttgacgt tcgtttttta 775681 ctttgaatat actcgtagtc tttttacttt ttgagtataa aaaaaaaatg actagcaaaa 775741 taaaattagt agtctaaaaa agaaagctcg cactcaggat cgaactaagg accaacagat 775801 ttgcaatctg ctgcgctacc actgcgccat acgagctttt gaattatggt aattttgatt 775861 atcctagaat gttatatctc aatatctcaa tatattttgg acatctatga aacacccata 775921 aagcagccgc taccaaacag acaagattca gtatgtaagg taaatacctt tttgcacagt 775981 taaactaccc aaacttatta aagcttgata aattactgaa attccacctt tcagttagat 776041 tcaggcctca tatagattag atatagggta cgtaacattc tgtcaaccaa gttgttggaa 776101 tgaaagtcta aaatgtcatc tattcggtag cactcatgtt actagtatac tgtcacatgc 776161 ggtgtaacgt ggggacataa aacagacatc aaatataatg gaagctgaaa tgcaaagatc 776221 gataatgtaa taggaatgaa acatataaaa cgaaaggaga agtaatggta atattagtat 776281 gtagaaatac cgattcaatt ttggggattc ttatattctc gagagaattt ctagtataat 776341 ctgtatacat aatattatag gctttaccaa caatggaatt tcgacaatta tcatattatt 776401 caccaattaa tcacaagttg gtaatgagtt tgataacaag ttactttctt aacaacgtta 776461 gtatcgtcaa aacactcggt tttactcgag cttgtagcac aataataccg tgtagagttc 776521 tgtattgttc ttcttagtgc ttgtatatgc tcatcccgac cttccatttt ttttttcttg 776581 gaatcagtac atagcaggta tgagttgtta gagctgttac aagttacggt aaacatttca 776641 acacaccgtt atttaacgaa tttatttgag aaagtggtgt attttaagat atatgtttgg 776701 tttcgattgt tggcaaagac tataatatta tgcatatagg atataccaaa aattctctct 776761 gaggatatag gaatctacaa aatgaatcta catttcattt tattacgtca tatatgaata 776821 ctagtcaata gatgatagtt aatttttatt ctagcatata tttaagtttg tttgcgaaac 776881 cctatgctct gttgttcgga tttgaaattt taaaactaca ttaatgtgtt agtttttctt 776941 tctttctttc tttgtcttga cgtgatttgg acttctgtct tgcattcgcg tccattcatc 777001 tgacccaata ttccttttgg ttttgttatc cttataaaaa gaaaggaagc ttcttagagg 777061 gaaaaaaatg atgaagagta atgccaaaat ataaataaat aaataaatat gaaaatcatt 777121 ttctattttt aatagaataa gaagagcatc ttaagattac aatttcaaga aatagtttac 777181 acagtatatc caataactcc aataaactac tttcctatac aaatttctat ggtgggatta 777241 atagtaaaac ttctgtactt ctctaattca ccaagaaatt aaggtaaaca tctggtaagc 777301 actatccagc tttttgctat tacacatatg gcttttctgc aatcatttct tcccattttg 777361 tctcaagccg ttagtcttga aaccacaggc ggagtagagt tacttgatgc ggtattttac 777421 atgccttttt tcactgcaaa aaaaatgaaa tacatattta cacgatttgc aggacagttt 777481 acgatagtga gtatgcagaa tagttaacac ctttgtttta tccttttgtg tcttaattat 777541 atgatataaa ggcgcctggc gttatcggat agtaatagat gctagttatc aacatttcac 777601 aattgaagga aataaagttg aagtactcaa caaaaactta cttcagaatt aaatttttgg 777661 ggggaacata ggcatcctat gacaggtgac cacaagcccc tcaacgcaat ctaatatttt 777721 acaaagtggt aaaattcttt cgttcttcgt tttaatatac agtcatttat tgattctatt 777781 acattaatat tcctacgctt cggctcacat aattaacagg acttcgagtc cgttaaactt 777841 gggatcaact aatttctacg gattagtgct tatgcctgat gtactgccat atatggtgtt 777901 atgatatcac ataaatgacg agaaacggcc atcgaattta gtggaagctg aaatgtaagg 777961 attaataatg taataggata gtaagtgccg acgtgtgaaa cgaaagaacg aattgtaatt 778021 ttaccatgta aagctgccca ctcttttttg gggattcctt tacctacgag agggcctgtt 778081 agaatatatg caataaagcc attcttatca gagatagact ccaaacaacc acctcaaaac 778141 ccactttttc ctcaagtctg cctaaactca aaaattatat gatagatgtt ctcaggagaa 778201 ttgggtattc agaagaacat tcgtaagaca ggccaaagta atatgaactg cctctgctta 778261 atggaataac gtgatttttg taccaaattg cctatttcag attcggcgtg cgcttccttt 778321 attcgcatag cacgcagagt acaatgtggc attaaaccct attgtcctgc acggaagatc 778381 cttgcaggaa tcaaatactg cctttcactt tgcaacctct taatcacata gtagcaccta 778441 tagacacgta ttctattctc tattataatg ttgttcaaga ttggatattg gaaaccttta 778501 gagcagtgca atttggcaag agataattcc agtatttaaa cagtggataa atatacaatt 778561 tccaaagcag tatgcctttc ctatggttat catcctccta ggtctttgca cattaggttt 778621 tccaagaaca gcattctgtc cctccataat gacaaattct acagtgagta ttaacacgcc 778681 tccaccatat cttactctag cttgtaatga aaaattacca acagttatgt caattgctgg 778741 atcagactca agtggtggag ccggtgttga agctgatatt aagactatca ccgcacacag 778801 atgttatgcc atgacatgcg tcactacttt gactgctcaa actccagtga aggtgtacgg 778861 cgctcaaaat ataccaaaga aaatggtatc tcaaatatta gacgccaatt tacaggacat 778921 gaaatgtaat gttattaaga ctggcatgct tacggtggat gcaatcgaag tcttgcacga 778981 aaaacttttg caacttggtg aaaatagacc caagttagta attgatccag ttctttgcgc 779041 cgcttctgac tcttctccaa ctggaaagga tgtggttagc ttaatcatag aaaaaatttc 779101 tccttttgcc gacattttaa ctcctaacat ttcagactgt ttcatgttac tgggcgagaa 779161 cagagaagtt agcaaactac aagacgttct tgaaatcgcg aaagaccttt ctagaatcac 779221 caattgctcc aatattttag tgaagggagg ccacattcca tgtgacgatg gaaaagaaaa 779281 gcatattact gacgttcttt acttaggtgc tgaacaaaaa ttcatcactt ttaagggcca 779341 attcgttaat actacacgca ctcatggcgc tggatgcaca ctggcttctg ctatagcatc 779401 taacttggct cgcggttatt ctctttccca atctgtttat ggtggtattg agtatgtaca 779461 gaatgccatc gcaattggct gtgacgttac caagaaagct gtgaaggttg gaccaattaa 779521 tcacgtttac gccgtagaga ttccattaga aaaaatgctc accgacgaat gctttacagc 779581 atctgatgct gtacctaaga agccaatcga aggttctctt gacaaaatcc ctgggggtag 779641 cttctttaat tatctgataa atcatcctaa agtcaagccg cattgggatg cctacgtgaa 779701 tcacgaattt gttaaaagag tggcagacgg cacattggaa cgcaaaaagt tccagttttt 779761 tattgaacaa gattatttat acttaattga ttatgtgaga gtttgctgcg tcacaggtag 779821 taaatctcca actctagaag atctagaaaa ggaccttgtt attgctgatt gcgcccgtaa 779881 tgaactaaat gaacatgaaa gaagattaag agaagaattt ggagttaagg acccagatta 779941 cttacaaaaa attaagagag gtcccgcatt aagggcctac tgtcgttacc taattgacat 780001 ttccagaaga ggaaactggc aagaaatagt tgtagccctc aacccttgtc taatgggtta 780061 tgtttatgct gtagacaaag ttaaggataa gataacagca gcagagggtt ctatttatag 780121 tgaatggtgt gatacttgcg cgtcttcatt ttgctaccaa gctgtgcttg aaggtgaaag 780181 gctcatgaat cacatcttgg aaacatatcc tccagatcaa cttgattctt tggtgacgat 780241 ctttgcaaga ggttgtgaat tagaaactaa tttctggacc gccgccatgg aatacgaatg 780301 atagttacaa tatttttaac agaatatata aaatacatat acagaaatga taaactataa 780361 acgcaaaaga ttagcgatac gaaaaaagga tttctcgcta ttatatcaat ttataaagag 780421 atcctttgga aatataaatt atgttcattt cattttttca acttctagaa ggatgactaa 780481 ctattgtttc catttgctag catggtaaat taatacattt ttgaatttgc tgctagggta 780541 caataccatg caatgtttat aatataaatc aaagtgacag agattcctaa aagctaaaac 780601 aaatccattg ataatataat agtaggttgg tcaattcacc gcagattcaa tgtaagtatt 780661 gatactccat aaatgttaac ttcaggttga tattcgttac aaaaatctta gtttgctttt 780721 cattactatc tgaacggaat gctcaacatt tttcttattc tacaattgta caatgtcacg 780781 taaacagttt gatttgtgta tttacagtgg aaacatttta cttgttggca atagtacatg 780841 cgcagataat caaaaaccat tgtttccgac attatttctg acaattgctt gaatttgctg 780901 aacacttttc gaggtacatt ctgataaaga gtgcattatt agttatttag agtatattaa 780961 gacatcttct cgaagatata taaattcgta aaggaaacaa aaatttcggg ataacaaaaa 781021 agtttcttct ttttacgtat taaatggtct attcatcgat cctatttcac tatcaatcct 781081 attatattat caacttttgc atttctgctt ccaccaaagt cgacggctgt ttctcatcgt 781141 ttatgtaata tcataacgca tgtatgacat tatatcagtg gcatgagcgc tagtccatga 781201 aataggagtt taactccaac atacggaaca ttcgcattat cgcacacgta agactcgata 781261 tattaaggaa ggaatttccg agttggatta ataaaggaaa aataaaatat agtgttggaa 781321 atatagttgc ctcagaataa tatcaatata atattaaaac gtatatagtt agatacccgg 781381 tattattcga gtacgcatta attcagcagt atgactttct gtgcctgctt atatattgta 781441 accgtatgtt gttctacctt aaaaatttgc taaattgaag gaattgacta tcgtcactga 781501 agagtattcg tattatggta ttatgataca ttgtctaaaa aaaggatacc atttttcttc 781561 aatagaacaa gaagagaatc taaggacacc atttcgagaa atagtttaca cagtatatcc 781621 aataactcca ataaactact ttcctataca aatttccgat ggttggatta atagtaaaac 781681 ttctatactt ctttcatcca tcaagaaatt aaggtaaaca tctggtaagc actatccaac 781741 ttttttctgt tacacatatg gtttttctgc aatcatttct tcccactttg catgagtaag 781801 tgtcccattt tgtctcaagc cgttaatctt gaaaccgcag gcggagttac ttgatgcggt 781861 attttacatg ccttttttca ctgcaagaaa aaaatgaaac acttatttac acgattttca 781921 ggatagttta cgctggtgag tatgcagaac agttaacacc tttgttttat ccttttgtgt 781981 cttgattata taatataaat gtgcctggcg ttaaaaaata gcaactgaat aagttttttt 782041 actgatgtcc ttgagagaag taactaatta tgaagtctcg ttttacatcc cgttgtctta 782101 cagcaacagg actcataaag tttgtaaact gccaaacgga attttagcat taataatatc 782161 ggatccaaca gatacttcaa gctcatgctc actgactgtt tgcacaggtt cccataacga 782221 tccaaaggat attgccggtt tggcgcacct ttgtgagcac atgattcttt ctgccggttc 782281 caaaaaatac cctgatcctg gtttattcca cacactaatc gcaaaaaaca acggctctca 782341 aaatgccttt accacagggg agcaaacgac tttttatttt gaattgccca atactcaaaa 782401 taacggcgaa tttacatttg aatctatctt agatgtgttt gcctcattct tcaaagaacc 782461 gctcttcaac cctttactga taagcaagga gatatatgca atacaaagtg agcatgaggg 782521 aaacatatca tcaaccacaa aaatattcta ccacgcagca agaatattgg ccaatcccga 782581 ccatcctttc agtcgctttt ccactgggaa catacactcg ttatctagca ttccacaact 782641 gaaaaaaata aaactaaaga gctcattaaa cacttacttc gaaaataatt tttttgggga 782701 gaatataacc ttgtgcataa ggggaccgca gtctgttaat attcttacga aactagctct 782761 atcaaaattt ggcgatataa aacccaaaag cgctgtaaag gaaaggagta tatcgattag 782821 gacgaggtca tttcgaagat cgaagtcttt aaaaaaacgc caagattctt ccaaaaacga 782881 ctacagtgac ttgaaaacct ttaaaatact gaacacaacg tgggaaaaaa aatacaaaaa 782941 tacgatgtgt tttcaacaat ttcctgaatg caattcgata tttatcaatt caaataaggt 783001 acctataatg agacttctct ttcctgttag cgataaaaac actcggttta caaaggatga 783061 cattaaaata tacagtcatc tttggtgtga acttttcggc gatgagtctc caggatcttt 783121 gagctattac ttagcttcaa aaggctggct cacaggctgt tttgccttta cctcagaatt 783181 cgctattggt gacataggat taattttgga attagaactg acaaacagtg gctgggaaaa 783241 tattaagaga attacgacaa tagtacttaa tagactcttg ccttcctttt acgtaatgaa 783301 catcgattac ttaatcactt ttttgaaaga acagaatttg atcgacctcg ttagctttct 783361 gtaccaaagt tcagaggatc ttccaatgga agagtgctca aaattaagcg gtattcttca 783421 ggacgattta gaatgtttaa ccccccctaa tatattcaaa ggatttaaat ctcttataga 783481 aatagatgat cccaacatcg aaaaatatga aaacacaaag gccaatatac aatggtggac 783541 agggcaagct attaagttcc aaaatttttt aaaatctttc atgaatcatg acaacatgcg 783601 ccttttactc ttagggaata taaaatctgg taatatattt gataaaatga aaaataaaag 783661 tgatatatgc accgattttt tctatgaatt tgagtattat acggcaaacg ttcatctagc 783721 aagtgataat aaatttcatt caaacagctc gtatgaattt aattttccca caggtaatct 783781 ttttttacca gattgcgtca gcgatccttt aaaactacaa cagctcttct tagaatgctc 783841 gttaaaatcg aaatttgcta cgcttagacc tcaaatttat agtgagccca ctaggacaaa 783901 gcctcaatta gtcagtgaga accagaatta tgagatgtgg atcttaaaag aagacccaaa 783961 ttttgcctca gacaataaat ccgtcgtatc atttgaagtt ttggggttag gcatcaaacc 784021 tagtccggag gcaacaatcc acctggaagt actagcacag gcattattta tcatcacctc 784081 ttcattcctt tatcccgctc tgagaattgg ttacacatat gagattgcct catctagtaa 784141 gggcaacgta acactgcgat ttactatttc tggattccct gagggtgttt tcacaatagt 784201 aaagacgttc gtggatacgc taaaacttat tgcaacagat ccaacgtttc tttctaaaga 784261 taccttgaga aaggcaagga ttttagttag aaataaatac aagaacgcgt catcggacaa 784321 ctgcgtgaag ctagctagcg ttggattgct gattgtttta gagaaatata tatggacttt 784381 agaggataga attaatgcat tagagcttac cgagttggaa tccttcgaaa aattttgttt 784441 tttattctgg aggaatccta aacatttggt cttgttcatg cagggaagcc ttgaatatgc 784501 tgacgcaatc aaccgttact taaataacaa ttttacgcag cacctaaaaa tcagcaatga 784561 agggagcaaa ccgaccatac gtctctaccc tcctcccagt acaaaagatc tagatcaagg 784621 cacaaatgcc tttatatcat ataatggtca ccaggatgat cccaacaata gtattgtgta 784681 ttttattcag actgcacaaa gagatgacat caaaaatctg acactaacct ttcttaccga 784741 atatctattt tcactaacgc tagtgcctga tctaagaaat aaaaagcaaa ttgggtacat 784801 tgttttggga ggactcaggg ttttaacaga cactgttggg attcatataa ccgtaatgtc 784861 tggcagctcg gggcacaatc tggaaactag gatcaatgag tacttatctt acttgcagct 784921 gcaggtgcta aatagattca ccgagtttga ttttcgaagg atacttctag agccgttctt 784981 aaatctttta aaacagaaca gtacgaaaca gtttgaaggg tcggctggtc ctgtagacct 785041 attaaatgag atagtggcaa atgtgcaaaa tggtgataat tacactctca acaataaaca 785101 aatgagacaa cataggaagg taagaaataa aattgcggaa ggaaggctta attttcaaga 785161 agatcatgaa atgattgata tctcattttt gcaaaaatta actctaaaga aatatttagc 785221 attcttcgag tccaaaatct ctatatattc cgctcaaaga agtaagctat caataatgat 785281 cacaagtcca atggcagaga aggaaattgc aagcaggaaa atgttccttc agctagaggc 785341 ctttctgaaa ataaacggat tcgccataaa aaatgaagac ttgaagaaaa ttgtcgaaca 785401 ttcaaaggga aatcctattt tacttgtaaa gaaccttttt acttattttc gtaggagaaa 785461 tgaagttttc aagctcggaa ccgttgtatt gcaggaaata ttgaaaatca tcggaatgaa 785521 tcttaagcag agatacggct ctatattagg gttttcttcc caagatggtg aaggacaaga 785581 aatagaaaaa ttttggaaca acgacacaag tccgattgtt cctcttcagg agcttcctga 785641 accaaacttt ttccgcaagg ccgcattttg aaccgtattt tgctcgttcc agcctttcca 785701 cgtttttgtt atctaagcaa cttggcacat ttccctacta tactacaaac cgatacgtaa 785761 atacttccct aaatagcata tgaattattc agtaattttt aaggatcgaa actgcacctc 785821 aactattcgt tactgtggtt atgttctcat gtattgatgc aaatcatggg atatttgctc 785881 aagacgacgg taaaatgagc aaaaatggca cgatcctgaa aagagcactt ttcaagattc 785941 gggctacaaa atgcaacata aaaaatgttg tattgtcatc tcgagagggt cttgtatgtt 786001 ttattcctct tatgattagt tcacattagt aaaacagata cgcagtgtgc tcttaataaa 786061 caactactcc atagctttat ttgcataaca aaacttttaa gcacaaactt aaacaggtgg 786121 agtaatagtt cggcggcgac tcaaattaca tttgttggaa gaatcgaata gaaaataaaa 786181 aaaagtgtat tatatttgac attcaaaatg gaaggtatga atatgggtag cagcatgaat 786241 atggacgcca tgtctagtgc atccaagaca gtagcatcga gtatggcgtc gatgagcatg 786301 gatgcgatgt ctagtgccag caaaacgata ttatcgagca tgtcatcgat gagcatggaa 786361 gcgatgtcca gtgcgagcaa aacgttggcg tcgactatgt cgtcaatggc aagtatgtcg 786421 atgggaagca gttcaatgtc aggtatgtct atgtcgatga gcagtacacc aacaagctcc 786481 gccagtgcac agacaacttc tgattctagc atgtcaggca tgtcaggtat gtcatcgtct 786541 gataacagta gctcttcagg gatggatatg gacatgagta tgggaatgaa ctattatctg 786601 actcccacat ataaaaacta tccagttttg tttcaccatt tgcatgcaaa caatagtggt 786661 aaggctttcg gtattttctt attatttgtt gtggctgctt tcgtctacaa actactgctt 786721 ttcgttagtt ggtgccttga agttcactgg tttaaaaaat gggacaagca aaataaatat 786781 tccactttac cttcagcaaa ctccaaagac gaaggaaaac attatgacac agagaataat 786841 tttgaaattc aaggtttacc taagctgcca aatttattaa gcgatatatt tgttccatct 786901 ttaatggatc tctttcatga cattataagg gcgttcttag tatttacctc tacgatgatt 786961 atttatatgt tgatgcttgc taccatgtct tttgttttaa catacgtttt tgctgtaatt 787021 actgggttag ctttatcgga agtcttcttc aatagatgca aaatagccat gctaaagagg 787081 tgggacatcc aaagagaaat tcagaaagcg aagagctgtc ctggcttcgg taactgccaa 787141 tgtggtagac atcccgaacc cagccctgat ccaattgctg ttgccgatac cacttccgga 787201 agtgatcaaa gtactcgcct ggaaaagaac aacgaatcta aagttgcgat ttccgaaaat 787261 aatcaaaaga aaacacctac acaagaagag ggatgtaatt gtgccacaga ctcaggaaag 787321 aatcaagcaa acatagagcg cgacatcctt gagaattcca agttgcagga acagtccggg 787381 aatatggatc aaaacttact tccggccgaa aaattcactc ataactaata actagacaag 787441 gttcgtccac ctatatcttc ttcttccaat atctctatac atcaaaataa gaatatcgtt 787501 catttctcag aagctcaaaa aaaatctcaa aatggatact tctaatgccc tcatgaagag 787561 gaaagaaaat aatagacaca gcgaccttcc tataaataac agacttgtat atagttgaat 787621 gtctaagtaa ttttaattca aaaatcctta actatattac caccttgcaa taataagagt 787681 gaagtgttaa aaatgatact tgcttgcctt catcgagtta ccgttgtctc ccacgtttct 787741 tttttctcgt tggacagaat tgcttccgcg cgaacatttt ccacttttat ttgaaagagg 787801 acattattca gatcgtgtca gtctcatcta attggcaaag tggcaatttt cgaaataaca 787861 agataactgc ataaagtaac acttgtcgaa ttgaaagtat tttgccagtg atatttaggt 787921 tcgagtaaag aaaatttcat aaagaaatca acaagacaca atgctgaaat acaggtcttt 787981 gccaatcaag agagcaatcc atcatccggc accaggaatt actccaattt ctccccgtat 788041 tatggtaagc aggttgagag taataccatc ttttaatttg aagttcaatc gttggaactc 788101 ttcggtgcca gaaagctcga aaaaggagtt aaaaacgaca gacggaaacc aagaaagtgc 788161 gagtaaggtc tctccagtaa aagagaagga aaaagtaccc tttaaggtta agatgcaaaa 788221 agcccttcgt cattattggg atggttccaa acttttgggg ttggagataa aaatttcttc 788281 caaattgctc atgaagagtg ctgcaggcta cccattgacg agaagagaaa atttacaact 788341 gaaaagaact actcaagata tcgttcggtt ggttccattt gctgctttcc tcattatacc 788401 ctttgctgaa cttcttcttc catttgcatt aaagttattc cccaatttac ttccttctac 788461 ttatgaatca agtaaaaaac gcgagaataa actagaaaat ttaagaaaca caaggaagtt 788521 aatgtctgaa atcataaaga ataacaagtc ccattttaaa cctaataata tttccgagga 788581 acaaaaagct ttgtttaaca ggttctacac acatgtccgt gctacaggag tgccggagtc 788641 tcgtcaacag ctaatcgaag tagctagatt attcactgat gatactgtat tggataatgt 788701 gacaagacct tacttgattg cattagcgaa gtatatgaat ttgcaaccat tcggcactga 788761 tgtgatgcta cgttaccgta tcagatacaa aatgcttgaa ttgaaaaaag atgatctatc 788821 tatatattac gaggatgcag aacaactctc cctctctgaa ttgaaaacag catgcgcctc 788881 cagaggtatt agaagtgtag acgtagagcc tagcgtgtta tattcgaatc taagattgtg 788941 gctgaacatg aggctcaagg ataagatccc atccacgctg ttaatcatgg ctactgccta 789001 taactacggt aatgtgcaat caaaggagtc attgtacgac gcattatgtg acgttttaat 789061 cggtatccct gatgaactat accatgaggt taaagtaaac gtcgttaagg aagatgaggc 789121 atccgctaag caaaaattga aacaattgag ggagcaagaa gaaattatga aggaagaaga 789181 gcagcaagaa gagaacgcca ttgtgagcgt caaggatgag ttgagcttgg acgaccaaga 789241 caagaacata gatgcggctg ctccagacgt aaaaccgcat gacaccaagc ctatcggaga 789301 agccgctgcc atcaaagaga agtaacccag ttttcacctg gcccattaaa ccgcacgata 789361 cactctccgc tactctcgcc aacattcttt ttatacatac ttgcacgaaa ctgctttttt 789421 agcaatgaaa agaaaatgta gtgaactcta ctatagattt tgtacataag ataaataaaa 789481 tacactacta tatgaaattt ttgtttgtaa agctggtgtt tgcacacata gatagtatca 789541 acgtagggga tcaacacatg cacgactact agaagcctta cccgtaactt cttgcatatc 789601 tgctttgcca atattttttt ttaaagttat ttcttaaact actcctcgtg ctgtccacat 789661 ttttacccgt tagttgttag acaaaaaaaa agcgcaacta tctccctttt gcgcatctcc 789721 caagtccttt accaaatata ttagaagaat gacacccggc cgagacggat gaagcggccg 789781 tctcggccgc cttaggaagg gatctgcgtt tttgttcgtt aatgaggtaa tcaagggcgt 789841 acttggtaga acggtactaa gttaatcatt gctgctctcc ctcaaaatta ctcaaagaat 789901 agagtgtcta ttgaaccgta gaataggcat ttattatata aggggttgtc aatttaccaa 789961 attttttact tcatctcagg actctctctt aaaattattt tccttgccat tttctatgtt 790021 atgtagaata gaaaaacagg tacatattaa ctaaaatata caccaaaaaa agtaaaaata 790081 aaatgtctgt cgccgatttg aaaaacaaca tccacaagtt agatactggc tatggtttaa 790141 tgagtttgac ttggagagcc gagcctatcc ctcagtcgca ggctttcgag gccatgcaca 790201 gagtggttga gttatccaga gaacgtgggc acaaggcctt tttcaacgtt ggtgaattct 790261 atggtcccga ttttattaat ttgtcgtatg ttcacgactt ctttgcgaaa tacccagatt 790321 tgagaaagga tgtggttatc agttgtaaag gtggtgcaga caatgctacc ttaaccccca 790381 gaggcagtca cgatgatgtt gtacaaagcg taaagaattc agttagtgct attggtggct 790441 acatcgacat cttcgaagtc gcaagaatcg acacttccct atgcacgaaa ggagaggtct 790501 acccctacga atcgttcgaa gcgcttgctg agatgatctc cgaaggcgtt attggcggta 790561 tttcattaag tgaagttaat gaagagcaaa ttagagctat tcacaaggat tggggaaagt 790621 ttttgacctg cgttgaagtg gaactttctt tgttcagtaa tgacatttta cacaacggaa 790681 ttgctaaaac atgtgctgaa ttggggttgt ccatcatctg ctactcccca ctgggcagag 790741 gattgttgac aggtcaattg aagtcaaacg ctgatatccc tgagggtgac tttagaaagt 790801 cgttaaagag atttagcgac gagtctttga aaaaaaacct gaccttggtc aggtttctac 790861 aggaagaaat agtcgacaag cgcccacaaa acaactccat tactcttgca caactggctt 790921 tgggatgggt taagcactgg aacaaagttc cggaatacag tggcgccaaa tttatcccaa 790981 ttccaagtgg ctcttctatt tccaaggtta atgaaaactt tgatgaacag aaaaccaaac 791041 ttaccgatca agagttcaat gccattaaca aatatttgac tactttccat actgttggtg 791101 acagatacga aatggcgtaa ggttaaaaaa gtgaatctcc attgtttata taaattttaa 791161 atttgatatg taaagattct aaacgcaatg tgcttatttc agtaatagta aggattctca 791221 agtggaagcc agcttgcgtt gtccgttgtg ctttaggaaa aaagaagagt acaagaatat 791281 tagcctcttt aaagattttg tcaattctcc tctgaaagca aacaacagac cttgcacaat 791341 gacacccttt gtcaattgag gaagaactcc cttccaaaga gattttaacc cttcattttt 791401 gtacaagtat agtagcgctt cttggaaagt agtgaattta gagccagcgc tttgaagcat 791461 tgctttagcg acaatcaagg gttgcgtaac tagagtcgaa atcatcttgg aaaggacacc 791521 caaaatgaaa ttttgcactg ctgacaaact gccagcatcg ttggaatggt catggaaaaa 791581 aacttcttta agtctttgaa aagaggcata tgtgatggaa ggatttatcg tcaatgctaa 791641 acctgttctt aaacctttcc aaaaagcagt tatgtcccca ttattttcac ggtaaatgtc 791701 cttaataacg ttggtaaatt tggcagactc tgcagaatgg actgtttgtt gtcttgtagc 791761 taccacagcc atgggactag taaaaagttg cgatatactg gcagctgcta ccccaagtac 791821 caattcttca atcgtagaag gtgtgatagg accatcgcgg tttttcagtg attgcagtcc 791881 taacagctta tgtttcatgt aggactttct gataaatgtg taccaaaaga aataaacaaa 791941 attctggaca aatgtggcca ccgtagtgac tgtcatacct tgatacagac ccaaaatacc 792001 cttttctttg aatatgttta tcatgcaatc tacaacattc ttatatctcc tattgggcaa 792061 aactttacct tcgttactat cctcacttga agaaggagat acttgtgact gaatgatcgt 792121 cttcgataaa tccagcggat aaactgcaat attggccatt gccgaagcca cagcgccagt 792181 taatgcagac tctagagtta acattgatga tatgctcgta acaatcttgg cctagcttcc 792241 agggtgtctg tacttttacg cagcatcata ttttctctat tttttgcaca tcttcttgct 792301 cttcttatat ttaccaatta tctgaaatag tcactcggac cgagatgcaa aaatcggatt 792361 taaaactcga tccgaggaga acaccaaatg acacaacttc tatcaatgca attgccctct 792421 aagtatcata gatgccgcta ttttaaatga cagtgcaatc gatttccata ttaaatggat 792481 aaaggtgttt attatgaaga tacccattac tgacgtatat gtaatgattc ctcagtccag 792541 taccatagtc ccgtcacctt acacggtgga aaaattaaac tgtacccgcg attgtaaaga 792601 ataacgtgga ggcagtcaga aagaacaata aacgaatagt gaggatgtcg tagaagaagc 792661 attcatcgaa aaacagcagc aaggcaatgt cgcagtacat cggtaaaact atttctttaa 792721 tctctgtgac tgacaacaga tatgtggggc tgttagaaga tattgactct gaaaagggta 792781 ccgtgacttt gaaagaagtt cgctgttttg gtacagaagg tcgcaagaac tggggtcctg 792841 aagaaattta tccgaatcct acggtataca attctgtaaa gttcaacggc agtgaagtca 792901 aggatttaag cattttagat gctaacatca atgacataca gccggttgtt cctcaaatga 792961 tgccacccgc ttcacaattc cctcctcaac aagctcaatc tccaccccag gctcaagctc 793021 aagcacacgt gcaaacaaac ccccaagttc caaagcccga atccaatgtg ccagcagctg 793081 tcgctggata tggtgtttac accccaactt cgacagaaac cgctactgct agtatgaatg 793141 ataagagcac tcctcaagac accaatgtaa actcgcaaag tagggaaaga ggtaaaaatg 793201 gtgaaaatga gccaaaatat caaagaaaca agaatagatc aagtaatcgc cctcctcaat 793261 ccaaccgcaa tttcaaagtc gatattccga atgaagattt tgactttcaa tcaaataatg 793321 caaaattcac gaaaggtgat tccactgatg tggaaaaaga aaaagaatta gaatcagctg 793381 ttcacaagca ggatgaatct gatgagcagt tttataataa aaaatcgtct tttttcgaca 793441 ccatctccac ttctactgaa actaatacca atatgagatg gcaagaagaa aaaatgttga 793501 acgttgacac ctttggacaa gcttctgcca gaccaagatt tcactctaga ggcctcggtc 793561 gtgggcgtgg aaattatagg ggaaacagag gaaacagagg aagaggcggc caacgtggaa 793621 actaccaaaa cagaaataac taccaaaatg atagtggcgc ctatcagaac caaaacgact 793681 cgtacagcag accagccaac cagttttcgc aacctccttc caacgttgaa ttttaaaatg 793741 atgtttctat gtaaattaag tatatcattc agtatgtaca tacaaaaatc aaattaatag 793801 tattatagtc cgcgcctctg gatagtatta ttttagtgcg tatcgcaaaa tatgaatagc 793861 acagaggttc attattatgt tctgagtatg aggacgaggt aatacatacc ttaaaatctt 793921 acatcatgtg gatagcattt atggcttctt ccatccggcc gtacgcttct gttcctgtcc 793981 ctagccatag cttttctcat atcaaaagca tctttattgt catctacttt tttcagggta 794041 tctggatacc catcttcagc tgagttataa tatcccacca ctctcctgta gacactgtat 794101 cccaattttt cgtaaagttt gatggccaat tggttattgc acttgacgaa aagatcgata 794161 aagttgactt catggggcat gacatcggtc atggtctcca aagtattaca taacttcgaa 794221 gctagcgata ttcggcggaa tcttggagct actgtcactg cagttatatg agtgtgccac 794281 tccgtggtct tgccttctgt ttttgccatc atgtaaccag agatattatg cttaaatgta 794341 ggatcaacag tcatttctga acttttgaaa aaaaggtctg gccatattat catgtattca 794401 aaataaaact ctaaagggaa gttttctgtt aagatatcaa ggttgacatt gttagttttg 794461 aataaatcga caggttcaaa aggctgaatt gttgtcattt ctcgaatcct cctgtctctt 794521 tccttgaata ttctcaatgt tccactatct ttcacataag caatattgtg aactatatat 794581 acttcattag atattgcttc aacattaata ttaataaaaa ggacatgcat aaagtaacat 794641 ccgaacatct ccaaacaccc atacatattt atattatcga cgagggaatt tttttcttcc 794701 caggcccacc aacgtgcgcc caccgctatg ttttttgcgc ctaggtaggt gggctagctt 794761 ctatgtatca aagctccttc tgcgcagccg aggttttgct aagcactacc gcattggaat 794821 gactgtgttt gtaggagctc cttgtctcca cgctttcgca attttcaaga tcgagatact 794881 attagtgatg gtaaggttat gaagcttaca tgtttaatat tgtagattcc agaagcaggt 794941 aagaacaaca aactacaaga aaagatgggt aaaggtaagc caagaggttt gaactccgct 795001 agaaagttgc gtgtccacag aagaaacaag tatgtacaat tatagaagat tgcactatgg 795061 ttgaaagatt ttcataataa gtagaagaaa ggatcggcca ttgctaccat gaaatgagtt 795121 ggaagcttga aaaagtaagg gagaataatt ttgcaagaaa ctagggtagg gctacttaat 795181 ttattatagc catttgaatt catcagcttt taggaggaga aaggccattt tgcgaatttt 795241 gaataagaaa gtccacaagt gatgaaactg aaaatctaca atgaatttct gccatctcag 795301 ataatgaatt cactacgaga acctcattta ctaacaaatt tattaatctt tttgatgaaa 795361 ctatgttttg tcaaaagtta atcgtttaaa acagccgttg ggccgaaaac aactataaga 795421 agagattatt gggtactgcc ttcaagtctt ctccattcgg tggttcttct cacgccaagg 795481 gtattgtctt ggaaaagttg ggtatcgaat ccaagcaacc taactctgct atcagaaagt 795541 gtgttagagt tcaattaatc aagaacggta agaaggttac tgctttcgtt ccaaacgatg 795601 gttgtttgaa ctttgtcgat gaaaatgacg aagtcttgct agccggtttc ggtagaaagg 795661 gtaaggctaa gggtgatatt ccaggtgtta gattcaaggt cgttaaggtc tctggtgtct 795721 ccttgttggc tttgtggaag gaaaagaagg aaaagccaag atcttaagca gagttatatt 795781 acgatttcat aattcgaaaa attctactgt gtatgtatat gtttaagaga ttaaataatt 795841 cttcaaaatc atcaaacatc aagcttattt aataatcctc ttaataaaac cacctagtgt 795901 tatttcgaat ttcttaaaca aaaaacacat acatatgata catatctcaa agcattacgg 795961 aattacctgt tttgttatta tttatgcttc ttgtttaatc ttgaagtcaa cctcttgtac 796021 atctcactat tgtttaaagt ggaaccaaca ccaactgctc ttgcgtttgt aggtactgcg 796081 ctaaggttac tcacaggagc atacttgtaa tcagtagtgg tttgtgctgg tgcggcagcc 796141 ctgtttctcc ttgcagcagc ttgttcgtac aaggtttgta ccgaagaacc acgagaggta 796201 ggatcttcac cagacttaga tttctttttc ctatttttgg cagaatccat aacggatttc 796261 tttctcaatt tttcagaatc aaactctaat tgcattattc tcttatctct gtagttatct 796321 gaagcaccaa taataggtct tgtccactcc gcaattaatt tttcagccaa cctagctagt 796381 tgagcttcga cacgcttgga ctttgtataa aagataacta ctctccccaa accactctcc 796441 ttcaggtgtt cagttttcac tggtagatcg tttaaagctg caaagagtga cttttgaatc 796501 tcaaaagatg gcagagaccc atcaggtaag ggttccaacc atattctgac actttgaagt 796561 aagttattat ccaaaatggt gtctgccaag tttgcctttg acagtacgct taccaccttc 796621 ggcaacaatt tgaccttctg catggcaatc agcgaagtat ctccagtttc tattctctta 796681 tttaaagtat cgatgtccaa ctgtgctgca atattcattt cgtctttaag ccttagaatt 796741 ttttcatcca agtactgttc taaatcgtct tcatccctcc tcgttcttct aacctttggt 796801 tttttcaata tacggtccag tttttcttcc aattcctgtc tactacttgg agtagcactt 796861 gaatctctat ctttactagc cctattttcc accgttggtt gaagactctg atcattatgc 796921 tcctcctttt ctaggtcgtc atctgagaaa tctgtgctaa tgtgcttacg tttcctttct 796981 gcagcttcta cgttactatt ttcgtctatt gcggcttcct cgttcttttc tccgttatct 797041 gggtctttag tatcattgga ggtacctttt gaagtttctt ggggttccat actttgattt 797101 tgttttgtat tttcattctc agcgtttata gttgactttt gggaggaagc tgtcccatct 797161 tctggtgtcg cttccaccac tttgggttgt tcttgatcgg ctgtactcat tgctaattga 797221 tatgtttttg ccttttatta ctaaaagttc ctctatatat acttcagagg acaataaact 797281 cccttgatat ggcctgcata tactttacaa gtgctatcaa acaaagatgc tgggcaatga 797341 agctgacagt taactcttcc aaaacttccc ttcaaagaaa ttgtgagaga aaaaaacctt 797401 cttgttaccc ttctttggaa gaataccgca catcataaaa tcaagaaatg aattcgaaag 797461 tttactcttt ctttctagag gcgttacacc aatattagcg aattgcagtt tcccacaaaa 797521 ggcgtccatt ggcatcaaat aactagatag tataaaatgt ttggtctacc tcaacaggaa 797581 gtctccgaag aggagaaaag agctcatcaa gaacaaactg agaaaacctt gaaacaggcc 797641 gcttatgtgg ctgcgtttct ttgggtttcc ccaatgatct ggcatttggt gaaaaagcaa 797701 tggaaataat tccccactga agaaaaaaga ttgcatctat gaatgacact aaaatatgtt 797761 tctctttttg tatttgcttt tgattaaata atggtcaatt tgcgcccccc accttatata 797821 gtttagagaa agacgtgtaa atatttttta aaaaattgat actgctctaa tgagcctaaa 797881 tctcctttct tcgcttgtat atatgcgtat tctgtatgtt tgtccaggca gatttttcgg 797941 ctttttttac cagcttttat tattaaaatg tgataacctt aattgaaggt tgcgatacaa 798001 aataatcctt tattacgcat aaccaaggaa aagagaaaat cagtgcacat atgggtttac 798061 ctgaagttaa ctttcttcga aaaaactgca tacttgtgga gttaaaatta ttctatcaaa 798121 cagtataccc accgaaggaa ctatattgga ataaccgaat aactgcagaa ttgagtacat 798181 tctccaatat taagtatgca aggccgactt tcgcagtaaa taatggcaca tttcagagaa 798241 caagaccgaa attagacttg gtactggctt catctgatat tcgtaagctg gctacggttt 798301 tatttaattt aaaagctctc ataatgaata cgaagggtga ggaacccact ctaaccacga 798361 tgactagtgt ccaaacgaac gaagagaaaa atgataacct ggaacagaaa tattcaagtc 798421 tgctagatag atggaatggg aaagtagaag tgcatgattc tcctttcctt caactccaac 798481 gggacagcaa ccttttgttt gctgagaggc cggtacgtta cgttagcact acagaaggtg 798541 aaggcgtgga catatctagt gaagagtttt tcaggttaga ggaagaacag tgccgaagga 798601 attatgatgt tttggtcgat gaacattcta caccatcagt cgggatgaaa gacggccaat 798661 acggaccaaa tataattcac tttgaaccgt cgctgtacca cacatattct tctctaccaa 798721 tgagtatgaa attttggtta aatggtctag aagacgacga aacgacgatg atgaacattg 798781 atgagaagtc agccgaaaat ctggatatat tattacatgg tttcaaagga ttttcgaaca 798841 agcgcgttaa aggatgaatt aatcatcctc ttcatgtact acttatgtcc aatttgagtg 798901 taaaatcaca ggtacaaggc ttatccatat tcgtatatat cttcataatg tttcataatt 798961 gcttcagaaa attattcaaa acgtcttgtg atattcatta ggtgaaatcg tagtttgcct 799021 gatacttgaa agaatctcac ctggagaatg ggtgttttca ctaagattcg ttaatttcca 799081 ctaatgatta attgttaact gtttaacgcg acgcgtaata aagtttcctg aatacgccaa 799141 catatgggaa catatagatt aaattaataa gaaagcttgg gaaaaataat tgagaagggc 799201 aagaagtgac gtaaatatac tagacgtact attatggttt cagttataga caagcttgtt 799261 tttgactttg gtgggaaaac tctggtctct ctcgcaccag ataataatac tttgtgtgta 799321 gccaataaaa atggcttaac caagattctg aagacaaata acccagaaga agagccagag 799381 actttagatt cttccaaatt ggtctcgtct ataaaatgct attcaaactc gcactttctg 799441 atgactacaa tgcaaggtga tgctcttagg tataacatcg attctagtca agaagaatta 799501 ttggctagat ttgctttacc cctacgtgac tgctgtgtta ttcattcagg taaaatggcc 799561 gtatttggag gagacgactt agaactaatc cttttggaat tggacgatga aacacacaaa 799621 aaacatgcca ttaaaatcga tgaacaagtt tctcaaattt cttacaattc acagatgaat 799681 attttagcag tttcaatgat aaatggtaag gtacaaattt tttctctgac atctactatt 799741 ccaaacaaag ttcatgagtt aaatgattac atagtggcca attcatatga tgatacacac 799801 agagataaga tactctcgaa tatgatggat gatatagata aagacaatga taatgacctg 799861 agtgaaacgg ctgatccaga tgagaacaat gtagctgatc cagaattctg tgctgctaat 799921 agaatttgca cgagagtggc ttggcatccg aagggtctgc attttgcgct accatgtgca 799981 gatgatacag taaaaatatt ctctataaag ggatattccc tacaaaagac gttgtccaca 800041 aatctctcat caacaaaggc tcatttcatt gatttgcaat ttgacccgtt acgtggaact 800101 tacattgcgg cagtagattt aaataataag ttaacggtat ggaattggga aacttccgag 800161 atccactaca ccagggaatt caaaagaaaa attactaata ttgcctggaa aatccaagcg 800221 gactcaaaaa ctctagacct tgttttaggt acctggtccg gtagtatagc cattgtccaa 800281 aatttggcag agtccgtagt atctaatata cctgaccaat ctgttgctga atcttcaact 800341 aaacatgggc tttttgtaga ctccgaatct gacttggaaa acttagaggg aaatgatgat 800401 ataaacaaaa gcgataagct attttcagat attactcaag aagcgaatgc ggaagatgtg 800461 ttcactcaaa cacacgacgg ccccagtgga ttaagtgaaa agagaaaata caacttcgaa 800521 gatgaagaag actttattga tgatgacgat ggtgctggtt atattagtgg caaaaaacca 800581 cataatgaac attcttattc gagagtacac aagactcatt cgtttccaat cagtttggca 800641 aacacaggaa aatttcgtta tatgcctttt tctccagcgg gaacaccttt tggctttact 800701 gacaggcgtt atttgacaat gaatgaagtg ggctacgtat ctactgtcaa gaatagtgag 800761 caatacagca taactgtctc tttttttgat gttggacgtt ttagagaata ccatttcgag 800821 gacttatttg gctacgattt atgcttccta aatgaaaaag gcactttatt tggccaatcc 800881 aaaactgggc agatacaata taggccacac gatagcatac attcaaactg gaccaagatt 800941 attcctttgc aagctggtga gagaataaca agtgtggcag ccaccccggt tcgcgttatt 801001 gttggtacat cattaggcta tttcagaagt ttcaatcaat tcggggttcc atttgctgtt 801061 gaaaagacat ccccaattgt agcgcttact gctcagaatt atagggtttt ttcagtacat 801121 tattcgcagt ttcatggcct ttcatactct ttatctgaat tgggtacttc tagtaaaagg 801181 tactataaaa gagagtgtcc acttccaatg agtttaccaa acattaattc tgatatgaaa 801241 aaagacgcaa atcttgacta ctacaatttt aatccgatgg gcatcaaaag tttgttcttt 801301 tcaagctacg gagatccatg catttttggg tccgacaaca cgcttctatt gttatcaaag 801361 tggagatcac cagaagaaag taaatggctc cctattctag atagcaacat ggaaatatgg 801421 aagatgtcag gagggaagga aacgacagat atacatgtct ggcccttggc tttggcgtat 801481 gacacattga attgtatctt agttaagggc aagcatatat ggcccgagtt tccccttccg 801541 ttgccatccg aaatggagat tagaatgcca gtatttgtta agagtaaatt actagaggaa 801601 aacaaagcta tattaaataa aaagaacgaa attggagctg acaccgaagc ggaagaaggg 801661 gaagaagaca aagaaataca gattcctgtt tctatggcgg cggaagaaga gtatctgcgc 801721 agcaaggttt tgtcagagct gttgacagat acactcgaaa atgacggtga aatgtacggc 801781 aacgaaaatg aggtattggc agcattgaac ggtgcatatg ataaggcttt gttacgttta 801841 tttgcgtctg catgctcaga ccaaaatgtt gaaaaggctc tttcgcttgc tcatgaatta 801901 aaacaagata gagcacttac tgcagccgtt aagatatcag aaagagctga gctgccctct 801961 ctcgttaaaa aaattaataa tataagggaa gctagatatg aacagcaatt gaaataaaaa 802021 aatgtaaaat atatatacgc aagagacaat tatttgatac ctgttcattt gttcaaatca 802081 tcgttcaaaa tgctcccaca ttaacatata tttctttgaa tgcgacgata ataaagagtt 802141 acgttgaaca tgatctgagc tggaagcgtc cttgcgaatt ttcgcgaaag gaaaaagtga 802201 aaaaatatga aaaaaaaaaa aagagatgac attttataga tgagctttga ttaaacagtg 802261 taacacctgg tcctgtaccg taaatattca aataagcatc aattcaaagt tctttatttc 802321 ttctttagca tttcaaaatt atagaaaatc tagaaaagat gtcagatgtt acccaacaga 802381 aaaagaggaa aagatccaaa ggagaagtta atccatcaaa acccacagta gacgaagaaa 802441 tcacagatcc atcctcaaac gaagatgaac aactagaagt ttcggatgaa gaagacgcat 802501 tggaatctga agaagaattc gagggtgaaa atccagccga taaaagaagg aggcttgcaa 802561 agcaatatct ggagaatctg aaaagcgaag ctaatgacat tttaactgat aataggaacg 802621 ctgaagaaaa agatttaaac aatctcaagg aaagaacaat cgacgagtac aacaattttg 802681 atgctggaga tttggataag gatatcattg cgtccaggtt aaaagaagac gttgctgaac 802741 agcaaggccg agtcttcaga tattttggcg ataaacttct aatatctgaa gcaaaacaga 802801 gctttaccag ggtaggggaa aataacctta cttgcattag ttgtttccaa cccgttttaa 802861 acaaatacac cttcgaggaa tcatctaatg gcgataagaa caaaggtagg ttatttgcct 802921 atacagttag caaagactta caactcacca aatatgacat tactgacttt agcaaaagac 802981 caaagaagct aaaatacgct aaaggaggag caaaatatat acctacgagc aagcacgaat 803041 atgagaatac cacagaaggc cattatgacg aaatcttaac tgtagcagcc tcaccagatg 803101 gtaaatatgt tgtcacaggt ggaagagata ggaagttaat tgtatggagc acagaatctc 803161 tatcacccgt taaagttatt ccaacaaagg atcgccgagg ggaagtttta tcgttggctt 803221 ttagaaaaaa ttctgatcag ttatatgcat cctgcgcaga ttttaagata agaacatatt 803281 caataaatca attttcccag ttggagattc tttatgggca tcatgatata gtggaagata 803341 tatctgcgtt ggcgatggaa aggtgtgtta ccgttggtgc ccgtgataga acagctatgc 803401 tttggaagat tcctgacgag accagactaa catttagagg tggcgatgaa cctcaaaagc 803461 tactaaggag atggatgaaa gaaaacgcta aggagggaga agatggagaa gtcaaatatc 803521 ctgatgaatc agaggcacct ttatttttct gcgagggtag tattgacgtt gtgagtatgg 803581 tggatgattt tcactttata acaggctccg ataatggtaa tatatgtcta tggtctctgg 803641 cgaagaagaa acctatcttc acggaaagaa ttgcccatgg tattttacct gagccctctt 803701 tcaatgacat ttcgggggaa accgatgaag aattaagaaa aagacagttg caaggcaaga 803761 aattgctaca accattttgg atcacatctc tttacgctat tccatattcg aatgtattca 803821 tatctggatc atggagtgga tcgctaaaag tttggaaaat tagtgataat ctcagatcat 803881 ttgagttgct aggtgaatta tctggcgcta aaggtgtagt taccaagatt caggttgtag 803941 aaagtggtaa acatgggaag gagaagttcc gtattttggc tagtattgcc aaagaacaca 804001 gactcggtag atggattgca aatgtttcag gtgccagaaa tggtatatat tcagctgtca 804061 ttgaccaaac aggcttttag attgctgata ttgccgtaat tttccatgcc cttttcactc 804121 tctcagaacg caaagcggct ccggctccca agtatataga aataagcata tagaatgaaa 804181 tgtatctttt gtaaaatatc taaaaaaaaa atagtacatg tattttagtc tttttggtac 804241 attaaaaaag ttttcattgt cacgtatctg caatggcatt cttcacaaag catgttagat 804301 gcggggggag gggaatgatt atggacaaga agaccaatat tattatttat tcttcaatgg 804361 aatcggaaat agaatgaaga attatgactc cctgatatgc gaatagtttg aacctaaaac 804421 gcgccaggac tgtttaaaaa taacaaaatc gaacattgtt agaatgaaac tctaacatgt 804481 tatctattta gtagtatgaa cggaaggata aataatcgaa atattattat gtagaaatac 804541 cgattccatt ttgattctta tattctcgag agaacttcta gtatatctgt atacataata 804601 tgatagcctt taccaacaat ggaatcccaa caattatcga attatgagaa atgggtgaat 804661 gttgagataa ttgttgggat tccattgttg ataaaggcta taatattagg tatacagaat 804721 atactagaag ttctcctcaa ggatttagga atccataaaa gggaatctgc aattctacac 804781 aattctataa atattattat catcatttta tatgtttata ttcattgatc ctattacatt 804841 atcaatcctt gcgtttcagc ttccactaat ttagatgact atttctcatc atttgcgtca 804901 tcttctaaca ccgtatatga taatatacta gtaatgtaaa tactagttag tagatgatag 804961 ttgatttcta ttccaacata ccacccataa tgtaatagat ctaatgaatc catttgttag 805021 ttaatagttt aaatgttttt atcggaagag gttttgtcat cacatcagca atgttcttct 805081 tggtctcgat gtagtatacg tatagattat tacctgatac ttcatctcta agtctcattg 805141 cctttgtgcc aaaaaatctg tttctaaatt tctcttcatt tgtagactta attatactga 805201 tcgttgatct actatcagta agtaagcctt taataattgg tttcttgtta agttcttgca 805261 caaggtgact gaggttattc aatagcggaa tagcttcact gactgcgtgt atttctgctt 805321 ctgtagttga agtgcatgtt aacgaagcct ttgtcgactt tcctccaatc acttttccgt 805381 tgagtaggaa aatgttacca atttgtgact tgtaatatgg ttggttacca tatgaagcat 805441 cgcttattgc gactagttta ttatctggct cggtaggttt gtttttgtgc catatcagtt 805501 gtttatctct agtgtcccac atgaattgta ttaactcata tgtcatgtct aaaacttgcc 805561 tagaggggaa tagtatatgt tgagcaagtg tgttgatgta gtatagtaag tcaaatctaa 805621 atttatatcc aacatatgaa gctagaccaa tcaacttttg catttcatgt accttctctt 805681 tgtattcatc ttcatctatt tctagttcat cctggtctat ataaagacct ggttgacctg 805741 gagcgctaag ttttcttcct tttggattca aaggtacgtt taatttgggt attttctcag 805801 ttaatgagtt ttccatacct aatttcatgt atttacctct ttgatatttg atttctaagc 805861 caagtatgtc gtactgaatt tcgttatcac tttcacccag atttattatc tttgtatcgt 805921 attgtttctt gagtgttgtt atgattttct tatttgcatt taagtctttg ctgaacaata 805981 tcatatcatc aacgaataag caaattgtta cttgactatt cttaaatacg catgaccatc 806041 cacgaacttc ttccatacca cactgtttta tcaggtatga tttgatagtt tcgtaccagt 806101 tcgctccact ttgtttcaat ccataatgtg atttcttcaa acgtatcaac ttatcattca 806161 ttcctaaatg tggtggaggt cttatgtata attcttcttt gatgtctgca tacaaatatg 806221 ccgaagatat gtctaattgt gtaatatagt agttattgtc taatgcaagt gacagggatg 806281 tcatcaacgc ataatgatgt acagtgttgg attgcatacc tgtatcgtac gtatcaggat 806341 gctgaatgtc acctcttgca acaaatctag ctttatgagt tccgtcacgt ttcttgttga 806401 agataaacat tgagtttatt actcttttag ggtctatttc ttttctgtca taatatttgt 806461 cagtgtccca agtattcatt ttcaatagtt ggttgacttc tttgtggtat gcctcgatat 806521 atttttcttt ttctttaata tctttattat aggtgattgc ctcatcgtat cgtaaggttg 806581 tccgtattgg tttgattgat tttactgctt ttacagctgc aatcaggtga attcgtttct 806641 tcgatctcgg aggttctaaa ctacgcatat tcttagtatt ccatgtgtct cgtgatacct 806701 taatttcagt ttcattatct tctaatgatc ttttcttact gttgatagta gtataggcat 806761 tagagtcacc aataccaccc aaactggaat tagtttgatg agaatttatc ggtgggagtt 806821 ctttaaatgg gtcagggaat tcggtaggag attctggagg tagatcaggg agtgggagat 806881 cagcgatgat agattcctcg gtattctgtt cagaaacagt agttggcgtt ttgataggaa 806941 caatattgtg cgatgaatta ttttccggtg gagaagcatc gattgaaggt gaacggtgta 807001 taatcctttt ctcagtctct tggtcactta tctgcggaac agttttgttg ttggtaccac 807061 ccgtactgga tattggtacg tttgtatgat tagtctcatt ttcactgtac gagtctgagt 807121 gtctgaaatc tttagattta ctggcgtgcg acgactcatg tgtgttagat tgggacatgg 807181 gagcaagtaa aggaacattt aatttatgca taccacccga accggtactc tcgatattgg 807241 aaatttgggg ggtgctagat ctcttctttg atggaagaat attagattca gatatgttgg 807301 ggtcaacttc tctgggtgcg cgaatattgg ttttagaaac acgtttcgaa tcttcagtat 807361 gagttgacgg aggtgtggaa tcggttggac tcacagcttt tgaaaggaca tttctcggtt 807421 gctcaggatg tagttcaatg tcggattgga agtcatggtc agattctatg ttaagatcat 807481 tggattcttg gatctcattt gacgcaatga acgaatgata tgaagcagtt aaacggttta 807541 agtcttcatc gaaagtgagt gcgtcgtaat tgaattgatc taatctggat tccttgccct 807601 gaagaataac atagttagtt gtatctactg tcttctttaa ggatggaaga tagatgatat 807661 atccataaga gtttcgagac ggatgtagag cgtagcctgg gatgccacga ggatgtattt 807721 tggagttagg gttgtgatca ttgacgataa caggttgacc gaaaggtaac aaagtactga 807781 tatcaagtcc tgccaagcca gcatgttgtc ttgcagattt tttgctttta ggtgaagcta 807841 gtgaatttct cacaatagta gaaaattcga ttgcagagaa ccataaatgg ttcggtaaac 807901 cactacattg cagttgagta cggcagtcat ctaataaggt acggtttagc cgttcagcga 807961 ctccatgtgc tcgggaatcc gctgtggttg tatagcatgg agttatacca tttttttcaa 808021 ggaatttatg gagagttctg ttagtatact cagaaccacg gtccatttgt ataaccaaga 808081 cactggcctg aaactggttt ttaataaaag ctagtatcgt agtaaaaaca tcgaggatag 808141 agtcctcgcg acggtcgtgt aatggataaa cccaacggaa ttttgttgtc tcatcagtaa 808201 atgagatgaa ataggatggt gcactttttg gtaggttgtg aactggacca aatatgtcag 808261 tatgtaggta ttgaaagggt tcgtatgaat tttggtattt tagtcgtgaa cctttgatat 808321 gtctgtgttt ggtgcttttg ccgattaaac aatcaggaca ttgatagtca atagcactag 808381 accagtcgac atctgattcg ttaaaatacg tgatggtgtt atttttaagt gagtatcgaa 808441 ttgtctgtgc attggcatgc gcaagcattc gatgaatgaa aggataagga tatttgcgtg 808501 tactttcact tgtatggaca ttattgatgg tgggtacgga gatatttgat ggaagcaagt 808561 actttttaga tacccagtaa aagtctccat attttacgat aggtgcaagt acagtgccgt 808621 cagaccgttc taagacgttt ttggtaaagc atgctgtgat atctactgca gccaattcat 808681 tcaaactgag taagtcatag gctatgttag gagtgtgcaa tacctttatt gatgttttgg 808741 tgttgtcctg gaagtgaaat tgtaggtcac caatagcgtt aattggtata tttctttttt 808801 gagcatcaac tacgtttatg tcaggattag atgatgctga gtgtatgtga tgagcagatc 808861 ttataagggt tcgtgatgct cctgaatcga gaaggaggtg tccagggagt tcatcatcag 808921 aatgattagt atgatttact gtagattcag taagtttctg gcctaagatg aaggtcgtgc 808981 ttattgttca attgaatcgg ttcagtagtt gatttactga tggaatcgtt gtccgtgctg 809041 ggagagttat tagatgtgga tacattgtga gccctggctg ttttcgattt cgaattattt 809101 gttttttgag gattccgagc tataactttg ggtttggttg tattcgtata gctgcgagaa 809161 tcattcttct catcactcgg atttctcctg taattaggtt tactgtttct cgatccctgt 809221 tgttcttcat aaatagcatg gatatctaag aacagttcag cgactgtcat atttagatgt 809281 cgatgacgtg tgtagcgtaa aaatttatat tcgccagata gacctctcat aattaattgg 809341 catgcgacct tgttattgat atgaatgcca ttattgttca gtctgtcgat aatgtttgtg 809401 acttttgttt caaatgcatc tgcaggtgta ctgccattat attgcaaatt tgccagggtc 809461 acaatgtcgt ttgcctcttg ggtatcagat tgcatttttt caatactttt ggaaagaatt 809521 ttcatgatat ccgtataatc aacggatagg atgtctttga cccaggtagg taggaattga 809581 gagggagcaa atatttgaaa agtgttatac aagaaggtga gttcatcatc agtgatctga 809641 cgtacgggtt ttccgtttac tgtcggaata ataccaccga gattcgagtt ttgtaaaaat 809701 ttgatgtatg ttttaaccca atttggaaag tcattaggtg aggttaacat tggtggtggt 809761 ctgacatatt ttttagtgga tgtcatatca gagtccgctg aggatgaatc agtaaatgta 809821 ttacctgact caggtgatgg agtgctcaga ggcgttccaa ctgatgatgg atactgcgga 809881 aactgtgatt gtggcccagg tggaaagtac ataggcgaca tttgataagg tgtatacgga 809941 atcatagatg ggtgtccgta aaatgaccaa ccagatggat tggcttggtt ttgggtcatc 810001 atgcactgct gtgggtacgg cccattctgt ggtgaatgtg actgagcagt ttgaggagag 810061 gcatgatggg ggttctctgg aacagctgat gaagcaggtg ttgttgtctg ttgagagtta 810121 gccttagtgg aagccttctc acattcttct gttttggaag ctgaaacgtc taacggatct 810181 tgatttgtgt ggacttcctt agaagtaacc gaagcacagg cgctaccatg agaaatgggt 810241 gaatgttgag ataattgttg ggattccatt gttgataaag gctataatat taggtataca 810301 gaatatacta gaagttctcc tcaaggattt aggaatccat aaaagggaat ctgcaattct 810361 acacaattct ataaatatta ttatcatcat tttatatgtt tatattcatt gatcctatta 810421 cattatcaat ccttgcgttt cagcttccac taatttagat gactatttct catcatttgc 810481 gtcatcttct aacaccgtat atgataatat actagtaatg taaatactag ttagtagatg 810541 atagttgatt tctattccaa caaattattc atcaaataca tctcgatatc catattttgg 810601 ttgcaaagaa ataaataccg gagatatgat tcagatgtgg aagcggtttt aaagtcccaa 810661 ttcatcatta tttgcgactc catggccaag ttggttaagg cgtgcgactg ttaatcgcaa 810721 gatcgtgagt tcaaccctca ctggggtcgt attttttact aaattagttt ttttttaggg 810781 aacagacgtt aagtttttta atattattat ggcatataga atggtgagta aaaataccaa 810841 atgatgaaat gaatttgttt tgtgagtcta tgataaaatg cagaatataa aattaaaaag 810901 ttcagaaata aataaataaa aaaaaatcta gtatcgcggc acttccgttc aatgtgccga 810961 cgagcagtta ctggggagtt gattcatgct tcttttgcgt gatgcaattt aggattatta 811021 cttttttcgt tttggccgct tactgtagct gatgacaatg aggagttttg gctgtcctca 811081 gtaggatttg tctcagacgc agaattagcg ccattgcatg tagtatgaag tgcatctgta 811141 tctacacccc actggtaata atctctccta acctccacgt aatcgtaagc gaattcgcct 811201 atttgatctt catccaaccc caatgcttcg gcttcctcag tgactcttag atggacaccc 811261 ggaattttac ctaatacgaa gcaaatgatg gccgtgacca cagcacaata gccggcagag 811321 gcaccgatat aggcaatttg aatatacatt tgtttccagt tatgcgtcaa ccaaccaccc 811381 ttatgctttg ttgtgccgtc cattccaata acccaatcag ctgcaaatag agcgttaaaa 811441 atcaatccca ccacaccggc gataccgtgt tcagctaata gatctaagga atcatccact 811501 tttaaataat actttatttt tgttgcaaaa ttacaaacaa cacccgctat tataccttgg 811561 atcaaagagc catatagagt aatacaaccc gagctaggcg tggcagcaac taaaccacag 811621 ataatgccgg agcataaccc aacagtggac catttttttt cagatcgata atctaataaa 811681 caccacgtca ttccacccgt ggtggcgctg agacaagtgt tcatgaacgc atatacggac 811741 ctcatatttg gtgacagtga gcttgcagca ttgaaaagca accaaccaaa ccaaagtata 811801 gaagtaccca aagtcaccat ggaaacatta tgtggtctaa agttgatcag gaggttttct 811861 tttcttcttc ctagaaaata agaataaacg aaaccagcca cagcacttag gatttcaata 811921 ttcccaccgc cagcccagtc taataccccc cattggtagg cccaaccacc tggggcccaa 811981 atccaataag tgatgggaca gtaaaccaaa gtcgcaaaaa caaaaagaaa aaccatatgt 812041 ggaaaaagct tacctctttc cgcagtggca ccagctataa tactcaatgc gacacacatg 812101 aacatcattt ggaaaatggc ataaatcagt tcaggatacg tggaatcatc cgaaattttg 812161 ccatagacgt ttctaaaccc aaatgaatcc aagttgccga taaatttgtt gttcgtcgca 812221 gtcttagaga atgctaaaga atagccccaa aaataccatt gcagtatacc tactaaggta 812281 gccattatca ctacccaaat caaagccaga gcagattttc ttcttgctaa accggaataa 812341 agaaagccca gccccggtac catgaagaaa accagggcgg cacctaaaat cataaaagcg 812401 actgtggaac tatcatatgt ctctgtccat agatgtccgt caccccgagc catgtgaact 812461 ctaaatctat atgttttcaa ttgtatcttc taaaaaaaaa atgccttcgc tttttacaaa 812521 acaatttcaa aagtgattgg acccttaact agcctgcatt gattgtaata gacaatcaaa 812581 gaaccaaaag agagaagaag cgaccgaaag aagacggcta tcagactcaa agcacacaac 812641 cttattctac aagataggaa agggagaaga tatctatcaa attgttgcga taagatgcga 812701 taagacaagg agagggaaag tccgtgctgc atatcagcat atcaaatctg ctaaaacata 812761 ttaacttaac atatatatat aatatataaa gtatgccatc gggtacctta actaaaaagg 812821 gtcatagcgt ggaaagcgag gaaaaacctc gagatggaaa accagtttat ggaaaacttc 812881 aaaataactc gcccgcctta tcgcgggcaa accagctacg agagataagg atttggcgcc 812941 gagataaggt ggagatgttt ctccgccgcg cggcactttt tgccggaact ggaactggtt 813001 tgaggtaggt caagaaagtg tcagtaaata ggagtgacag aaacgggcac atctactctt 813061 ctttttcttg tttgtttcga ttaaatgcaa tacatactcc taaagacata tatatataaa 813121 tatgtatgca tgcatgcatg ccttcataag tatttctact tcctcttttt acgttgatcg 813181 ctgatatatt ccttcacaaa attcctctta gattcaacat ctaacttccg tgagactagt 813241 ttatatttgt cgccaccgtt taatgcaacg cgtaattcct ctaaattatc cgagagtact 813301 tgtggctcgt tgatcttgca tttaacatta atgcccttgt tcagaaatct agataaatac 813361 tccatattgg agatgggcaa tgtggtgatg gcagttttat tagttttgat ttggatggtc 813421 tgcaattcaa attttttagt tttggccatt gcggggttca ttgtggttat tgaagggtct 813481 atgaattctt taagtttttt cccggttata ctaaacggta agacgctttt accattacat 813541 gaggtaccct cagcaaacat aaaattcacg gtattgccca attgagatag ctctgctacc 813601 tcgtggccat agagttttat atctaaccca ccggcgagga tgaagttgat gaattctctt 813661 atggaaactt tgtatacaat gtcattggat gggaccaaca acgtaacagg cccttgagct 813721 aataacacca ctgaaaaagc atctaaaggt gaggtacaat tgcaaatata aagcttgccc 813781 ttctgtggat aatgcttgga tttccttacg tcacgtttct tgattccttg cacggtaatt 813841 tcctctttcc aactgaatgt aaacttcaat atcaaaccca gtaagttgtt ctggccagtt 813901 agaaggtaca gcataatcaa tggtagcatt ataatggttt tcacccctag gatacccaac 813961 aaacacgctg tcatcacctt actaggtttc ctgattgtgt ttggtagaaa tggagctatt 814021 cccgtaccat tgtctctcca attggtgtac ttttccatta cttttcttgt attttgtcac 814081 ctcgtaggag ctacttcttt cacgccagga tctgacagta tttctattac gttactccag 814141 tcacgttgag aaaaggcttc atctttttct tttttcttga gataactttt ttcttctacc 814201 ttcactcaga ccgagatatc ggacctcaaa catagcgttt ttttttgtaa aacacttaag 814261 gatggaggaa catgtatgct gagtaattcc agcagaaacc atttactgag agcctcatct 814321 tttgttaaaa aatttgttta ataaaatatt tcattttcaa aaaaaaaaaa agtaaagttt 814381 tccctatcaa atgtctttta gggatgtcct agaaagagga gatgaatttt tagaagccta 814441 tcccagaaga agcccccttt ggagatttct ttcatacagt acatcattac tgaccttcgg 814501 tgtatcaaaa ctgcttcttt tcacatgcta taatgtcaaa ttgaatggtt ttgaaaaatt 814561 agaaactgcc ttggaacgtt ccaaaaggga aaatagaggc cttatgacgg tcatgaacca 814621 tatgagtatg gtcgatgatc cgttagtttg ggcaacacta ccatataagt tatttacgtc 814681 tttggacaac ataagatggt ctttgggtgc acataatatt tgctttcaaa ataaatttct 814741 ggccaacttt ttctcacttg gccaagtcct ttcaacagaa agatttgggg tgggcccatt 814801 tcaaggttct atagatgctt caataagatt gttaagccct gacgacactt tagacttgga 814861 atggacccct cactctgagg tctcttcttc gctaaaaaaa gcctactccc cgcccataat 814921 aaggtcgaag ccatcttggg tccatgttta tccagaagga tttgtactac aattatatcc 814981 gccttttgaa aattcgatga ggtattttaa atggggtatt accagaatga tcctagaagc 815041 aacaaagccg cccattgtag taccaatatt tgctacaggg tttgaaaaaa tagcatccga 815101 agcagtcaca gattcaatgt ttagacaaat tctaccaaga aactttggct ctgaaataaa 815161 tgttaccata ggggatcctt taaatgatga tttaatcgac aggtatagaa aagaatggac 815221 acatttggtt gaaaaatact atgatcccaa aaatcctaac gacctctctg acgaattgaa 815281 atatggtaaa gaggcgcaag atttaagaag cagattagcc gctgaactga gagcccatgt 815341 tgctgaaatt agaaatgaag ttcgcaaatt accacgcgaa gaccctaggt tcaaatcccc 815401 ctcatggtgg aagcggttca acaccacgga aggtaaatcg gacccagatg ttaaagtcat 815461 tggcgaaaat tgggcaataa ggaggatgca aaagtttctg cctccagagg gtaaaccaaa 815521 gggtaaggat gattgaaatt taagcaatta aattcgtgta aatactagca tgtatgaggt 815581 catttttaca taacaaatat tcattactta ctttgctttt tatctgtgcg cattaaaatg 815641 agtttcatat ataatatagt tacatgtgat gaatgtatgg acagtctctg tcatttgtca 815701 aaggagtgaa aaagaccaga aaaggccttg acctcatttt ctactaacca atctggtaga 815761 attcacttta gacgcaaatc ttaacgaatt gagagtctca ttaatatgag aggagcttgg 815821 tgaaatgttt acaaacatta atgttttcga atccccagtg agtgaatatt gcagtaggta 815881 tgtcagtttt gagttcctga acggtatatg tcttttggta ctatcaggct gacctaaagc 815941 atgaataacg tcacctaagc aacttaaaga tttatttata ttttgtgttt ctcttaatct 816001 atcccctaca acttgagaga catttattct ttcggaaccg gccaaatcaa caagatttag 816061 tgtgccatac gagtgtgctc cagtttttgc atttgatcca gacaaatgaa ttatgaaaat 816121 actgtgtgaa cgggaggaat gctcatttga tgctgtgcta gcggtggatc ttaatttatt 816181 tgcttttttc aggattattt ccaccatttc ttccgactca agcttgcaac tcgtaacatt 816241 cgttatcgtg gtagtcttag tttcctgatc atgacgtatt tcgtgcttta agccaatgct 816301 tgtgtcttct ttattattat tatcacttct caataagtct acgatgttct cgttgtagat 816361 ctcaatgaat tcgcagttaa ctttataatc ccatcctttt gtctttaatt tattgatcca 816421 gttaaatata tgagatattg tggacggaat gataccatca cctggattta acatcgtgaa 816481 agttttccca gatcctgttt gtccgtatgc gaagatacaa acattatatc catctaatga 816541 actttgcact aactgaccaa cttctttaaa aacatccaca tttgtatcct gttgatcaaa 816601 tattttatca aatttgaatt catgcacttg cgctgtgttt tgtattttcg tcacttccat 816661 agattgaaca ccactattgt catcaaattc attaacatta ataaggctag tatcagaatt 816721 ttccaaattt tttagagctg gacgaatcct acaataaact cgtatatttc ctcttaactc 816781 ttgtaactca ttatgcaatg tgcgtctaac cgtttcctct ttaatcagaa tttcattcaa 816841 ctccttcata cccagttcag tgtcttttat atattcctca agttctttga tcttttccaa 816901 agtttctaaa ttagttttct gttttaatgc cacctcatct ctcagccttg tagtttcctc 816961 ttccttttct ttaactttta ctttgatagc ttcatacgcg ttacgctttt ctgttaagag 817021 cttctttttt tctgccaact caggttttaa tgtattttcg atttcctttt ttatgctttc 817081 gatttcttgc atatgtttat tattcagctc tatatccttt ttccactgcg attggtactc 817141 tgtaagccat tcttcttttt caagcatatg cttttgttca acatcgttca acatttcctg 817201 taaagtggaa gggttcatgg tgattttatt tcttacctct tctattttat ctaaaagcga 817261 cgctctttca ttttcaaact gtttaatctt cataaatttc aatttctcaa tttttgtttt 817321 gtattcattt tccatttgtt tcagctcttt tttattagat gccgctagct gctttaaatg 817381 tatttcatgt ccttcattca tgaactgctt ctttgacaaa aattcttctt taatcgagat 817441 aagttcattg tttttcaaat tcagttgctg ttcaattttt atcttttctt cacgaagggt 817501 ttcaaatttg agattaacgg cattgatttt ctctttcgtt tctgttagtt catctttgag 817561 taaatctagt gttgcctttt tctcaaataa gattgcttgt gttctattga gttcattaac 817621 attttcttta taaaaggaag ttacaccgga gttgcttttc tggtttccat aaatcaaatt 817681 tgctgtacct ttataattct ttaaaagctc gcgattaggt gacatggata tgcgactctg 817741 actagctaat gagtgtctat gaatatccgt acgttgcggc ttcagaagag tgtgcttagg 817801 cggtggagtt gttgtatttc ttcttttgtg gccattcata gctaaaatat cattcttcgg 817861 cgatggtgtc gagagatgct gcgtagatct gccttttgtg ggagtacgtg gaagtgattc 817921 catagtttaa tagttgccag aatttctcta agtcctttat ttcaaaatct acctttttta 817981 aacaaagact ccggatagtt gttctggtat attcaaatag aataataaga aacacaaaga 818041 gcggaaaaat tgatagcttt aatgcttata taatattcga taattttttt agctgtaata 818101 ctcatcatca tattttgatt cgaggcgcat caaattgtaa acagtgtttg ttttgatttt 818161 gtttgagatt cattttggtg tatctccatt accctcttat tggaaaattt tgaaagaaaa 818221 aaatctagga ttcgatgccc ataagatata aggaaaggta ataaacagat gctatgaata 818281 aagcgataga gaagccgaag gaaaatcagt acataattga tcatgggctc caagcacaga 818341 gtagacacta aggataagaa aagaaccaga aagaatgcag aatttgggcg tgaaaaaagg 818401 aatagtggca accaagagtt aagtaatgag ccggaaaaag atacaataat ggaaggtgat 818461 gaagccgaag aagacgagca gaatagctct agcgatgaat catctaaaat tatagataac 818521 gaacaaagtg atgctgaaga agatgatgat gaagaagaag aggacgacga cttcccaaga 818581 aagaaaaaat cgaaaaacag caaacatgat gatggttcta ctggattttc tgctgcagta 818641 aatgctattt tatcatcaca tctgaaagca tacgacagga aggaccccat catggctaga 818701 aacaaaaagg tgctgaagca aagtgagtca gaaaagctag aatacaaggc caaaaaagca 818761 ttgttggcag aaaaaaaaaa gttattaggt aaagccagaa agacggatat tattccaatt 818821 gcttccggag aagacaggtc agaaaatatt agaaaagtcc ttgagaagga gacagcgctc 818881 agaaagatag ctcaaaaagg tgccgtgaaa ttatttaacg ccattttagc aactcaagtc 818941 aagacagaaa aggaagtatc cgaaaattta agcgaaatta agaataaaga agaaaagaaa 819001 gaattgatca ctgaagtttc caaagaaaaa tttttggatt tagttaaagc tgccgcagga 819061 agcgacaatg aataatcaac atgttcatgt caaaagaaga aaaaaaataa agaaataaaa 819121 actgtatatt atttagtcta tgtcaagcga gaaaggggcc ctatatcttc cctcctcctt 819181 gcaattgaat tttgtttgca ttctatatta tcatatagtt tcatatcaat tgcaaaaact 819241 tttgcagcca atgttacaaa attgttttca atcaaagaaa tacaggtgtg gtgtccttca 819301 ccatcgatat attaatatta atatatcatg aataaatata aaaattcaag gtaatgtact 819361 tgtgcacttc ttttagaata tagcaatttc ccttagctct ttttcaaatt gtaattctct 819421 acaatacata aaaagaaatt gatctttggt tcaactttat atatcgcaat aagcaattct 819481 caacattatg aaagtttatc taaattaaac aatcttcaac aatagaatgg tctcttggcc 819541 cagttggtta aggcaccgtg ctaataacgc ggggatcagc ggttcgatcc cgctagagac 819601 catttatttt tgacccaggt ttttttccta ggcaaaattg ataacaggga cttactattt 819661 tctatttttt ttttttttta catctcaaac aagggaaatc gatgactctg ttgatataaa 819721 tgtatatata cacactttta aaacttcgtt gttcatcttc gctttcacca tgctacccca 819781 ggcaagtaga cgttaccttg ggatgacgct tcgctatcgc cgtcttcatt atcaaaaacg 819841 tttgtgaaag cctcaaattc taacgtagga agtgtcttca actttcttga agattctgca 819901 ttgagcaaag aatcatagtt ccagtctaag aaatcttcca tgttataact tagcttctta 819961 aatggttgag caaatatctt cgccaacgtg gctacattag gatgataatg ttccatcaat 820021 gacgccagct cccacagaga ggaatccagt gcatgagtta actcagggtc cgattcatga 820081 acatcgaagg gatctacata gttttctttc agagttttca agttcgccac ttggtcaggt 820141 gtctggaatg ggttggaaat gaaggctggg ttgtgcagca taatcataca attcggatgt 820201 ttcctgatta aattatagat gaagggaatc acggtgacaa tagcagaggg tggtgattct 820261 agggtgagtc tggctagctt tttgatgaaa gatgctacta aatgggcgga taaatgtgtt 820321 gatgacaaaa atacgtccat taacctgaaa aatcttgctc tgtatttaac atgcattaag 820381 tctggattta taatttgata aagtttcata taaaaatttg gatattccaa gttgaatctt 820441 ttcatcaatt caaaaaggcc attcagagcc aagatcggaa caacaccggc gtttttatta 820501 gagctttgca aattgtagga atcagtaagg aaatccatta gtttagttgg agtgtggaaa 820561 tgaggtatta ttctcttatg caaaattaac agaatagact tatactgctg taaagacaat 820621 tggccgttta aaagggataa ccaatttttc tcgaaattgg acttgaattt ggactcgttc 820681 tctatggctt gtgggggatt tggtacaaag atctctaaat ctgcatcaac actagagcaa 820741 tgtttgtcat gatttactaa agctaaccat ttaccaacgt ttttcaaaag caagtcctgg 820801 taggctggat cctctaatag ttggttaaat tctgattgaa agtagtattg aatatctgca 820861 aatttcgtat aatatttttc cgtgaattct actatgatta aattttcaga cgcacccgag 820921 cttttgacat cctctatttc acccatgttc gaggaccata gggcgatgat taactttctg 820981 aatgttttat tggggaaaaa tggtgcgccc ttttcagatg caaaatgagt tgattccagc 821041 tctgcaagtt gaagatagac atcaagcgaa tctaacccaa gtgatgtttc gaaaggtatg 821101 tccgaaatga tagctaacag cttcgtcttg aacgcttcat acacctttct acaccaatta 821161 acaaactgtt ccttctctaa tgtgctcttt ttggacgaag gaagggtcaa gtcgccgcgg 821221 gaaaacagct ttctaaatat ctggaatagc gacataacca gaaatctcaa atttttttct 821281 gtctcatctt cttccaattg agtaacattt tctggaatca ctagttcatt gattaacttg 821341 ataatggagt tgtactgctt tctgtcaccc gcagcagtca gcctcttggc aatatcttta 821401 atttctgata taagcaatac catattcttt gacgtttctt tttaatagat ctctcttcat 821461 ggcaatagag gatgataatt acatctcatc tcatctcatc aaaaccgtaa tacacttttt 821521 tttttctcag ttggaaaatt ttagtgaaaa atttcaagaa tagccctaaa ccttcaaata 821581 cgaggattac ccgtagagaa gtgctgaaaa acttttttct ttttcttttt tttcgatttt 821641 catttaacag gtataaaaag cgaaacactc ggtacatata ttttaccaag acgcgttaga 821701 ttttctttgg aggtttcatt taaagaaacc aatgaccttc caagttttta aaagaatacg 821761 atgatattat ttgcgtttca aatcgaacaa ttcttctcgg agcgatctga ggttttaatg 821821 gagatagcgg ttcctgcgca acccattgat cttgttacat tcttaagaat gacaaggacg 821881 cttttataaa attctgattc ttttttcttt cattcttttg ttgtttttga cttgggagta 821941 gtcatctcat ctgtacacaa gtagcttttt atatgttctt aaattgtaga ctagtcaaaa 822001 cttgtgtcct ttaaaccgtg ccgaaacagt tttaaagcgg acatccaggg aaacttgccg 822061 ttaacaataa gtgaccttgc atggaagact gtcgattggt ctctgtggaa accagtgcat 822121 atctaaatta aatctattgt catcacgaat gccgcccgtg ttcgtgcaac gtgagcgcaa 822181 atacgcctgg ggtctgtctt tctgcgctgg aaagcacctt cgggcatcaa ctaccgtttc 822241 ttatcgctgg cactatctat ccaccaatca cacggcagca gtactgctgc cgtggacggc 822301 aaattaggta cagggcctat gactgttatc atttggcagg ctcagacaga gagagagagc 822361 acaaggaaaa gagccttaac tcatgtaaca tttgactcat tctgtaaact gaaaatttgc 822421 tgcccactcg agatgacaaa tagttcgttc ttgaatttat gcgcatttat agatacgcat 822481 atataaccct atagtgaacg ccactaggag acagattctg tttggaccct gatcgcatac 822541 tcttcttacc tttacataat aaaataagaa aaagtataac ttgctttacg ctaaggatat 822601 aaatcggacg taacttaaga tgtgtggtat tttcgccgct ttcaggcacg aagacgtgca 822661 tagatataag ccaaaggctc tacaactatc aaaaagaatc agacaccgtg gtccagattg 822721 gtccggtaat gctatcaaga actccactat atttgttcat gaaagactag ccattgtcgg 822781 tgtggaatcc ggtgctcaac caattacttc ttcagacgga gagtacatgc tatgtgttaa 822841 cggtgaaatc tacaaccaca ttcaattaag agaagaatgc gcagactacg agtttggaac 822901 actgagtgac tgtgagccta tcatcccaat gtacttaaag cacgatatcg acgctcctaa 822961 gtacttggat ggtatgtttg cttggactct ttacgacgct aaacaagatc gtattgtggc 823021 agccagagac ccaatcggta ttacgacatt atatatggga cgctcttccg cttctccaaa 823081 gaccgtttat tttgcatccg aactaaaatg tttgactgac gactgtgaca ctatcactgc 823141 attcccaccg ggccacgtat acgattctaa gactgacaag atcacccgtt acttcacacc 823201 agattggctg gacgaaaaac gcattccttc caccccaata gattacatgg caattagaca 823261 ctccttagaa aaagccgtta gaaagagatt aatggccgaa gtcccatacg gtgttctatt 823321 gtcgggtggt ttggactcct ctttaatcgc ttccattgct gcccgtgaaa ctgcaaaggc 823381 cactaacgat gtcgaaccat caacttacga tagtaaggca agacatctag caggtatcga 823441 cgatgacggt aagctacaca ctgctggttg gacaagtctc cattcctttg ccatcggttt 823501 accaaatgct ccagatttgc aagccgcaag aaaggttgcc aaattcatcg gctctattca 823561 tcatgaacac acctttacat tacaagaagg tttggatgct ttggacgacg tgatctacca 823621 tttggaaact tacgacgtta ccactatcag agcttccact ccaatgttct tactatccag 823681 aaagattaag gcccaagggg tcaagatggt tctttccggt gaaggttccg atgaaatctt 823741 cggtggttat ctatatttcg cacaagctcc ttctgcggca gaatttcaca ctgaatccgt 823801 gcaacgtgtc aagaacttgc atttggcaga ttgtttgaga gctaacaagt ctacgatggc 823861 ttggggtcta gaagctcgtg ttccattctt agacagagaa tttttgcaat tgtgtatgaa 823921 catcgatcca aatgaaaaga tgattaaacc aaaggaagga cgtattgaaa agtacattct 823981 aaggaaggca ttcgacacca caggagaacc agatgctaag ccatatttac cagaagaaat 824041 tttatggaga caaaaagaac aattttccga cggtgttggt tactcctgga tcgacggatt 824101 aaaagatacc gccgaagcag tcatttcaga tgaaatgttt gccagtccaa aggccgaatg 824161 gggtagtgac attccaacca caaaagaggc tttctggtac agactaaaat tcgatgcttt 824221 gttccctcaa aagaccgtgg ctgacaccgt tatgagatgg attccaaagg ccgactgggg 824281 ttgtgctgaa gatccttctg gtagatatgc ccaaattcat gaaaaacata tcgaataaat 824341 aacattaaaa aatagaaaaa gaattatgga ttaatcttat agatattttt atagaaaaac 824401 aaacactaac aataataata ataataaata gaatatagaa atacatattt ttcataatag 824461 tttgatgaag ttttattcat aaatcatttt ttatcgccag tgctaaaaaa ttaagtgtgt 824521 ggatgactgt atatatgcgt atcgaacgat cttgatgcaa atcattttga aacattattc 824581 ttgactttga tatttcctat tatacatcct ccttccttga gacccaataa tcttaaaaat 824641 gatggagaca gtgcatgccc tccttttcac ccttctttta tgtcgtttct tacaattttc 824701 gagattcttt tgaatctgat ctccttttac cttgtgactg aagattccta atcgaattgc 824761 tcctctctag cgacgccctt tgtttcattt cgtgtgcaat tagtagatcg tgccttgtta 824821 ttactgtatt cttatttctt gatttaattt ccgctcgata gttttgcgga tattgactat 824881 cacttttctt aaatattagt tttatttttc tgaaggcagt gctcatatgt aaagtagtaa 824941 cgttgttagt gcagtgttag cagtcaaacc taaaaataaa agtataaaaa aactatatct 825001 attttttttt tgtttgttta cgcacgttta tatatttaac acggtgaagt agtcctgcca 825061 ttatgctgct ctaacacaag agtcgtatat ggatgagcta atgactaaga tccgagtagc 825121 gaagtcatgt atgcaagcta acgcaacaag gctgtaaaga atacaagcct tgtcacccta 825181 gtaccagcat caagcaaatt gctcatttac gactgtgcca tgaagtaggg atgaatgagg 825241 tgtttctgat gacacctctg aggagctttt cttgagctcg tttctgtgcc actttttgtt 825301 cccgcggcta agccgcgcag accgataata ctcgcttaga tgcacatcaa gccaaatctc 825361 tataaaaaaa tcgacgtttc ccaaacgacg ctgacccttt attcatcgtt atcaaaaaaa 825421 ggcagctttc cagtgtactc atacgagaag caatcgatgc ctcacttccg tttgtagata 825481 tatacatatt tacatgcaca ctaatgcaat tatatgcgag aacaatttgt gagatcataa 825541 ggtctcgtaa actgtcaatt gttgagcagt cacccagaat tgagagttgg tataaaaaca 825601 ctattaccct catcgaagcc attgcattca aacttgccat cacactaaaa aaatgcattg 825661 atagcatatt ctgcatgttt tactacaaat gaatgaggta ttttgtcagt gacatcaatt 825721 tttaagcgtt cctgcttgac tttatcctta taataatccg acaaatgtga tctggtctta 825781 ccagaaaccc aatggtcgtt gctactgaag agaaaccaaa tagaaattcc gttctcttcg 825841 caataattga taaatctatc ttgaaactcc cagttcgtag ttatttcttc catctcctgg 825901 gcagctaatc ctagagattg acgaacaaac tgcctatgag tcaaaaaaat tcttgtagat 825961 agtactgcct gataaccagt acttccacag cccataaatt tatcaataat aaatcttgaa 826021 aacccttctg ataagatcca ataaaagaaa atataactga acaatgatac cacatgagcc 826081 aatggtggaa tataacgaag tgccgctgtc attttgatac ccatctcaga ggtgtgaatg 826141 tccatcacag ttggtgtaac gagaccaact ttttgtacgg agccaaccag tttgttagaa 826201 aggcatactt tttgtacgat gtatgcccca accgaatgtc ccataataat aattttcctg 826261 ttcttgcatg agaaattgtt aattacctct acctgatgat ctacttgatc ttgtaaagaa 826321 aatatcggtg tattagaatg agcgttcaat gtcattccgg catgggatat gccaagaatt 826381 tcccaatctg ggtgcttcaa gtgtagatga tgtagcattt cttgataata gtataaaagc 826441 ccaggattac cagggatcca tactagaaga ggcgcatcct cgccactttt agtgactgta 826501 ggtttgatat tcaatatcga gcatggcaac ttcgatttag tatactcttt tacagtcatt 826561 tgtcactaga attgagcagg cgggcaatgg cgtagcaagc ggactgtcta ttttccctcc 826621 agtagttttg ggctttgctg ccgttttaat gctgttttcc tttcctctta atgagcgctt 826681 tccagttgcg atacttttcg ggtaaggaat tgtaaggaca gcgacgcaat tcaagcggtt 826741 aaatagaaga aacttacatc atatataatg tttaaaaata acaatcaaat tactttatac 826801 atgaatgagt aatgttttag ttgcctgatt tgctaaattt ccaaaccatt tagaacttta 826861 aggtttgcct ccacttcttg gacacattgt ctaaagtaaa ccaactggaa attctggaac 826921 agttttatca agcccagaat ttcagaactg tcagtgattt cttccattgt ttccactgct 826981 gctgtagtat tggagacaaa ttcatcctcc agtttttcca gtaatttatt atcctcagat 827041 tcttcaatcg gtggctcatc atttactttg ttactcttta aatcttcttt tctatcagca 827101 acgtcatcaa cagtaggctc attcgcttct ttctttgatt cctcttcggc accctctgat 827161 tttggctttt catcctcggt agaaggcgtt tcgtcaaaag aggtggtagt gtttgcgcta 827221 atgtcctttg cgctaacatc cttgctatgt gcttctcctg tggcttcagc ttttttcgcc 827281 tctaactctg cttcttttgc tttgacttca taacgcattg tatcaaattt gagtcttgat 827341 tcttccactt ttttgcgcag gtcatggacc ttcttgaagt cttggtttat taatgtttct 827401 aattttttgt tgaattcctt gaccatcata gaatccatct ctgccttccc ttcatcgata 827461 tttttatagc atgtcgacca cgaatcgaaa actttgatca aattagacaa atcttcatca 827521 tcttcttcat cttcttcatc ttcctcgtct tcttcattat ggtcggcacc ctgagcttcc 827581 gttgtctgtg cagttttgat agactccttt ttcttcttta gttctgcctt ttcgttgtgt 827641 tctaaatttt gaaattcaca ttcgcagtca acagcggctt ttgagatggc ttgagcaaaa 827701 gaccttggca aaaaagcatc gtcatggtta gatccctttt ttttagtgga actttcggat 827761 tttttagagc caaaccagcc atctttattg agagaccacc aatccgaaat actctccgtt 827821 aaatttggtg gatagtcgta gccctctact tcgaacgttt tggacaccag tagaatcctt 827881 ttacatacct tctctaagga atcacttttt ttctccaaga attggtactg tggtggtaat 827941 ttacttatat ctgatacagt acccaatgat tcctgaacaa atctagttcg cgatttgatt 828001 gatagtcttg tttgagggtc atttaagttt acatttgcat ttgctaatgc attgttcaaa 828061 gtgtcttggg tcttgtgagc agcggtggca attgaatcgg tgatcttgtt tagagaaaac 828121 cctgaaaaat aaccagacat tttctaacca gaattttatg gttttaccta actttgctgt 828181 tcagatgtat aagtattgca accttttttt ccctgatcat tattatttca agagaaatga 828241 aaaccaaaac tgggatatgc gtgtcgagtg ctaaaaaaag ccaactagcg atttaagagt 828301 gagaagtaat cctcgttaaa agcgatgcag agccaactaa ctaaactgct aacctcgctt 828361 tctttacaca agtagtactc aagaagtttc ataaaatgcc cagttacaca ctcgtgaaat 828421 gcacttcaag gtggtgttac aattttcacg aactgcaaca attgagtata tttattaaag 828481 caggaatatg tttgcccaat caaacgtaat ttcatatatg aacatatatg aagttgcaca 828541 catcagcggg aaagatgtct ctaccgctcg aggagccaca cgtttgattt gcaatccatg 828601 aaatagaact gctaatccca tatacaatta actatatcaa tttcctgaac aaagagatta 828661 caatcaacgg caaagccgcc tgcctctccg gagatctcct tttttcttct ttcttttgtc 828721 ctatgttgca tagttgctca tgtcttttcc ttaggcggac aattaagagc agccacaata 828781 tttccaaaac taaattgcta aaaaagcgta gcaaaaaatt ctcgtcattc ccactttccc 828841 taccttaacc cttgatgtta acgccgtttc gctcatcgga acaaactata cagataatta 828901 agcttttcgg cagcggtgag aaaggaagca gccaggagga atacgcggct ttctcgcgga 828961 gcccgattgc cgatacaaag gaactgttgc ctcctcccgg ctatttccat aggccttcat 829021 tcagcatact gttgtgtagt tgcatcacat ccttgttgaa tgaattccaa ctatttcgat 829081 aaaccatccc atgaaggaga atgcaatgcg gcttttgttt gtaaacgggc ttgagaggtt 829141 ctatgcggtt aattctgtca ctaggggtcc gaatctcgga ttaagtataa aatatgtatt 829201 accctgatga ttgaccggat gatgtaagga tgcatgtccc tactgttttg gtatttccac 829261 atacggacgg ggccccgaaa caccaccccc attttaacgg ccgcatctga gcatcggccc 829321 atttggcaca cgcccgttag tgacgttggt aggggcattt ccctgaggta ggcccaaggt 829381 tgctttaaaa ggtccatcgc aaaccccttg tccgcggacc tctgcgtcat aattaaaatg 829441 cccaaaacat aaaagtgatc gccccctcac agaaacttat gggcagcttg ctgccttaac 829501 ggaattgact agaattggtt tgattttttt ttcttcctac ttcttcttcc atttccctcc 829561 cctcttcctc atatatgtat acagaaaaat cataccccta taaattcctt ggccccaatc 829621 ttctgtcaga ttttccttta taaaagagtc tttgttttgt aattaaaaga tacttttttc 829681 tttcttcttc tacgtctcct tttttttttt taagaaaatt taacttatac cactattttg 829741 ttcgcaattg atcaagaaaa aatacaattg aaaaggtttt acatttttaa tttttctgct 829801 catcgcgctt ttttaaaagg ataaataaac atttctttaa aaaacatctt caataagaaa 829861 aatcggttaa aaaaactttt cttctcaaag catacctaat aacaatataa tcccataatg 829921 ctagccctag ctgataacat tctacgtata ataaatttcc tatttttggt tatttccatc 829981 ggtttaatca gttcgttgtt aaacacccaa cataggcaca gctccagagt aaactactgt 830041 atgtttgctt gtgcatatgg tatattcacc gattcattgt acggtgtctt tgccaacttc 830101 attgaaccat tggcatggcc actagttttg ttcacactgg actttttgaa ctttgtgttc 830161 actttcactg ccggtacagt gttggccgtt ggtatcagag ctcactcatg taacaacagc 830221 tcatacgttg acagtaacaa gattactcaa ggttccggta ccagatgtag acaagctcaa 830281 gccgctgttg cattcctcta cttctcttgt gccatctttt tggctaagac cctgatgtct 830341 gttttcaaca tgatctccaa tggtgccttt ggttctggtt ctttctccaa gagaagaaga 830401 actggccaag tcggtgttcc aaccatttcc caagtctaat tgaagcgcac caacttaaat 830461 tttacgccac tttcaattaa gaatataata aatggacacc gtgaataaat tagggaaaaa 830521 agaaagcaaa taagaaaact ccgttttccc tcatcccttt ccgtctttcg gaagaaacaa 830581 aaaattatac ccaaggaaaa cccgaaaaaa atgaaaaaaa taccagaaaa aaaataacaa 830641 atcatatgca cttcttcatt aacgattatg aagaagtctt atttctaact aatattatta 830701 ttattattat tattattatc attcaccccg ctttctttta ttataatttg ttcttctaat 830761 attttaattt ttaatctttt catactattc ttatatctaa ctaaagtatc cttctctttg 830821 tctagtttta cttcactaca tacctgttgc gttgatttga gttttttgta tgtaagttct 830881 gtttatcctt tttcatccta ccgttccgcg cacggcgtga cgtggatccc taatgtgagt 830941 tcaaatcggt tacaaaaatt aatagttttg tttcctatta ttattattat tattatgtat 831001 gaggaatcgt gctataaaat cattttccat atgtatatgc caaatattta ttatttattt 831061 catctttttt ttgcttttgt gtgtcaaccg catttgcagt gccttgtcaa acggcttcaa 831121 ctttctcatc atatatgggg gcacgttttt ccattcagga aaatattcca tacccatact 831181 ggacgtagac caccaattga atggcaacag ctcattgggt acggtgggat tgtacttcca 831241 tgtaccgttc acgccacctg acattatacc accagtgcca cgttcaccaa acaatatgtt 831301 cttgtgcttt ttctcatcga tcgtcttcgc ctctgcgttt gttttctcgt tcattgttaa 831361 taacgtttgc aaggactttc tcttcttatc tctgaatagc gggttttcct tcactgggta 831421 cattactggc ctgtatccgc tatacagaat atcgcgggtg agctccctag cttccaaata 831481 ctgtgtagta ggtactttgg gcagcgatct aaagtcatag aaatgcgcat tctttaaaat 831541 ctttgaactc ctttgcttgg taatttgttg atgttgctgc cttatggggt tcaccagtct 831601 gctgtgagtc cttctttgca agcttacaaa agagacgctg acgcccctaa tttttgtcct 831661 ctttaataaa atcatcctta ttcactattt ccgtacgtat atatgtcttt gtatatacgt 831721 gtatgcgtgt gtgtttcgtt actctctata attcaactaa aatgtataca tgcagacaca 831781 cactcagagg gaaaaaataa atgtgctata aataatgaaa cacaagaaac atctaaagtc 831841 cgaaaattgc acctgctctt atcattcatt cttatacaaa agtgactaga tatgatggcg 831901 gatcccgcag ccccaatcac tggcaaagag cctgaatacc gataggtaca ctaagcgtaa 831961 agaccctacc gtattctggt tgctatcacc accccacttc catcacgtcc ataccaggtg 832021 cgtaagctta atcactcttt gctcccctgg tctgcccttc ctattccgga tttatcggct 832081 cgttccccgc gcccactggg gtaaaccggc ttgatggccc gacctcggcg gctagccacc 832141 gcacccagac cacggtcttc tccagaatgc ccacgacgta gtagcgtggt tccgtcacca 832201 ctattgggct gacacaacac ctgtgctcaa tgctcagcaa tatatcctct atactactac 832261 tgtccgcggg tgctttcaga agtgtttgcc atcggtcgat aagctctttg tcctgacgca 832321 gcgattcgac tgcccccgta aagtctcgtt cgtgatcccg taggcaatcg cagaaaatct 832381 ctttccgctg ttccaagtcg aacgtcttat aataaaacag cagttgggaa acgaatttgt 832441 cttggtcgcg cttcgacggt atatactcct tgattttgta ggccttgtat aacgcttttt 832501 gttgtttcct tatatcttgt gggatggtgt cgggtgcgat tgttcccgca ttagcaacaa 832561 tttgtgccag ataatggtat tttgttggtt ctagtacttc gctatcgtct tcgctattat 832621 cttcgctatc gctttcttca gcggtggcat tgccactgcg ctcgccgcac cattcttcga 832681 aaagactttc acgaactgtg tcatctctga tcttgtaaaa atcaggatcg ttttcgattt 832741 tcttgctttg cagcgaccac gtggaaaact tgtctagttt atacctatcg aataattcga 832801 agaagatatt acgctcgtca atgtcatctg tatcaatacg attcagatca tcgataatgc 832861 tgatatcttg atttacaatt tgttcttcat tctcttcgtc ttcctcttcg tcttcctctt 832921 cgtcttcctc ccccgaagat gaaccatacc cgctgactag cccagtgtgg ctttcctgta 832981 aaggggattt tacgtcaccc gcctcttcgc tgatctcatc ttttctctca acttcgtctt 833041 gatttctttt aaatagatga atctcttcgt tgcaagattc gaggatttta tcaatgtcct 833101 cctcccgcat agtgtaacct ctggcaacgc caatcagaag aaccagtttt tccttatcta 833161 acgactcgat taatgagcga cacctgctgt cgtcctcttg actgatgtca tttttgaact 833221 ccttagagtc atcattaaag taaagttttg taccatcgtt gtatattatt aagtgccaac 833281 cattaaccag ttctaatgaa aatgttggct tcctctctgt ctgtgattct ttcgcattgc 833341 tttctaggtt agagcctttc ttcaaattag gtttttccca tcgagactgc ttcgtgttct 833401 tattatagta atactttttg cctgcaggtg tcttaaattc ctgccattct ccacgcatgg 833461 cgattctgtg ttactgaact gtctttctct ttataataca tatcagaatc tctttcggac 833521 actatttcct ctttcttcaa ttatattgtt ttctctttca ttgccgaaga aaaaaagaaa 833581 catactgaaa gttgataaat atgcaataat aaaacctttt cctactcttg acgcttctgt 833641 ataagataaa aactgccaac aagatcagtt ccaacttcct gccgtattat gaggtatgtt 833701 attcattacc aagactatat ccgccacggc tggatgcagg catcgctccc tgtggcttaa 833761 gaaaataata ggcacaaaac taacaataaa aacatccact actctgtcgc atgttccctg 833821 tgctcagatc attcgtaaca aataacgata tacctgttgg atatgtaacg ccaaaattcc 833881 cctcattata ctggcccatc aacaactcga agtataatac tgcattctta tactatatat 833941 ctgacatttg gaaattttcg ctgtactgga ctttgatctt taatggtgca ttttacgtta 834001 ctgctggtgt gtatgctagc ttgacccata gaaagaaggc tggaagtgta tggatattcg 834061 tcatgtacgt cttatacgga ggcgttcaag gcttgacgac tggtacagtt atggggtttt 834121 taataggtgc gatctataga tctggtttat tttctatgtc tacatgggtc ccactttgtt 834181 gcgcagtagt ccaaatcctt ttcgatgtgg tgctaagtta ttccatggtt ggttccgtta 834241 tgtgaaagct tctgtcaaga aaaaacaaga aggggtttac tgatttgatg ataaaagtta 834301 gcagcaactt ttgaatgaga atgtgccatc cttcacgtaa agagcctaat actctttctt 834361 caaagcgcta gattgttcta aacgtttctt taactattgt tttcgttcgt gcagcgtgat 834421 taaccgagcc tccttcgagg cggggatgga tattgtaagc tgcatatata gtcgaacctc 834481 aaatcggttg agacaatagg caaagtgccc acattggcgc aaacacaaga acattaggaa 834541 agaaggcaat ctgatatttc aaaaatgtct gcttcattga ttaatcgttc cttaacaaac 834601 attaggacag aactggattt tctaaaaggg tcaaatgtca tttcaaatga cgtttacgat 834661 caaataaata agagcttgcc ggcaaaatgg gatcctgcca atgcaccccg caacgccagt 834721 ccagcttcct tggaatatgt cgaagctctt tatcaatttg atcctcaaca agatggtgat 834781 ttgggcttaa aaccaggtga caaggtccaa cttttagaaa aattatctcc agagtggtac 834841 aagggtagct gtaatggccg taccggtatt ttcccagcaa actatgtcaa gccagctttc 834901 tctgggtcta acggtccatc caatcttcca ccacctccac agtataaagc tcaagaatta 834961 caacaaatcc ccacgcaaaa tagtgccgca tcatcttatc aacagcagcc atttcctcca 835021 ccttccacaa attattatca gcagcctcaa caacagccgc aacaagctcc tcctccccaa 835081 caacaacaac aacaacaaca acatcagagc tcacatagcc acttgaagag ctttggtagc 835141 aaattgggta atgccgccat ttttggggca ggcgctagta ttgggtcaga tattgttaat 835201 aatatctttt aagtcgtttt tctctttata tacttcattc atttgttctc cattatggcc 835261 aaacctttca taaattgaac gaagttctac ctttggtgtt gttatcccta gaattttttt 835321 ctaatgagta tgaatttaag taaccttttt ttttcttttt ttttaaacag atatatcgta 835381 tatggaggat aatagtacat cacttatgat atgagcgaga aaatctgtct ttttagtaaa 835441 aaagtataaa aagtaaaaag gcgtcgattt tgcgttgatt tctttatatt tacgtctgta 835501 caaaaaatac attaagaata tattcaatat cttccctttc ttcttcccca gcaggctata 835561 cgctaatgga ttaaaaacct gccatatacg tggtatatcc tgttgacgac atttatatga 835621 gctccggagt caagattggt atccaccagt tcctcaacgt ccctaaacca ttctttcttt 835681 cttgaacgcg ggatcaaaaa acttcccaat ttgtataagt tagaaacctc aatcactagt 835741 agaccctggt ttaagtgttc ctcatcggcg tccgcacctt gtttagaata attcaaaact 835801 ctttccacat tattcaaact tatacttatt tgctccctat accgtttttc attagaccag 835861 acattgccta gtttgacaaa tctttttaac gccactatag aagaatatag tatcactaaa 835921 gccggagata atgctacaac tccaaacacc aactgttgcg atttcagcat tttatcaatg 835981 ccattcaatg ccatagatcc atcgactttt gttttttgca gttgaatcaa taaagacctg 836041 actaatccac ccgtagctat attctttatc ggatgatgta gttgtgtttc atatatttcc 836101 ataaattcgg tcaaatcacc atgttcgact ttagtactca atagaatagg gtctatgggg 836161 ctgttagacg tcgaatcact attatccaca acaaaactaa caatcattct ggtaagagaa 836221 tccatgtcag agtttaatgt ctcctgtgat gtcactgaaa tggcgcttcc ctcgtcatgc 836281 ttaacagtag accaaacctg tttcaggggt gcccataacc agttcaagat cagccctttc 836341 gcaaagtcaa cgacattggt cttaatgaaa tcttgaataa aataccggga attccacaac 836401 gacataacag aagatggtcc atataaaaga cacaacaaaa ttgaaggcca gtatctagtc 836461 aatatacttg gtttagtgaa ccttcttaaa ggatgatctt tatgaaattt cgctgagcat 836521 cggatcacat ctagtaaatt cgaatcagac atggctaatc caaagaagtc ctgtaaagat 836581 tttagacgtc tttcgtagtt cggtaaatgt acttcggtga acataccatt ttcttctggt 836641 tgttgatcga attcagtgat caactgcccc agtttaatag tataatactt tgatgattga 836701 gtgaccatat caagtctttc gtgcactata ccgcgaggta tatcagaaac caatgaagct 836761 atttcaattg gtttcttcgg tagcccgaca aacctgaagt tccgaatcac cataaatttg 836821 tttattcttg ggcgtatttt ttctagtaaa tcaactgaca aggcctttag ggaccatttt 836881 tgatgcgaca gttttttctt atttacatcc ttcaaaacag tttgagataa aagacgtatt 836941 gtcgatactg aattttgtaa acagtaaaga aaagacttta ggattgaatc acttactgtt 837001 ttgtagtact gttcagcttc atacacggca ggtaaacctt ggacgcattc gttggtcaca 837061 gaatagtagc acaataatat aatgtactca aatatggctt ggctaacaag atattgcaaa 837121 tctccgtctt caaaggatga gggatcagca atgtccttgc aaatattgta tagcaaatca 837181 aaaggcaccg aacaataaga gtcaatattg tcagttttga ttgaaatgca gattttttca 837241 acaattgacc tgatcaattg taattgatct tgtaacctac ttagttcttc attttcctca 837301 cgtacgtctt gaatcaattg ttgctgtgaa tcaaatgcaa cctctcgtag tgattcctct 837361 aatgaatgac ttatctcttc aaaagatttc aaaatacgcc tattgatgat catttaagaa 837421 tattaattaa ggaacctgca attttgcaat aggactattt tgttgacttt gttgttatta 837481 ctaagtttta aagtggaaaa gaattccgac cctttgttta gtgagtgggg gtcaatcaaa 837541 ttcgtattcc tcggtcaaat gaggaggaat gtaaaaaccg aaaataaagt catcgcatag 837601 gtacaagaag aatgaacttg agaagttcaa atttctaatt caattttttt ttttttctat 837661 acatataaat taataaagtt actcacggtt tgaaggtcaa tcaatatatt tgtttaggat 837721 agcaatagat aaaagaacaa tagagaaaga atgtaaaata cgtaaaaata tatgtacatt 837781 actgtcggat aatggtttga atgcatgttt gatatgtttg cttatgtttg cttatgtttg 837841 cttatgtttt tatcattact actactataa tttttcatta ttatgctcga ttcgtaaaat 837901 cgttactctt attcaatact atctatggaa taatccttct tggataactt atgtctcaaa 837961 cctttgcccc agtaagaaaa tgcaaaaggt aaagcaatca tagcagtgga gatgaaagcc 838021 aacaaccaag aaccccagtg cagattcaat ttgtggtaca tttgaatggt aaacaagggg 838081 aaggcagcac caccggcgga tcttaagaaa acctttgtag ccagagcact ggatgcgtat 838141 tggacgtagc aatcaataat gtaattattc aatgaataat aaatcaacac cataccgaaa 838201 ccaaaagcta aaccagctga agctggacca acccaaataa tatgtttata agcggtagca 838261 cccaggatcc ataaagcaat tgcagcaaat ggagcaccga tcttagcacc tagcaaacga 838321 tcttcaggag taggtttacg ctgtttgaca atttgtaaat acttgttttc acagtagaaa 838381 gttgtggcta acgcccaaag agcaccgata acaataggaa taaacatcaa acccacaagg 838441 ttgtctttgt agccatatag ttcaccgaaa atgacaggga aggcaaagaa gaacgcatat 838501 agtagagagt aaatcaaaca cacgtagaaa caagtagcaa ctagaacagg ttcagtgaca 838561 gagaagtaca aaggtctcaa cagacaagcc ctcatcattt cacccatact gacaccttgc 838621 gcttcctgct cagtcataat cttgggatta ccagtttcct ttcttaatct agcagccttt 838681 ctcttcaaga taactggagc gtacgtttct gggatggcag aagatatgat ccacataaca 838741 cctgcaaagg ccatattgac ccagaaaatc aggtccatac gtccggtaga aacggaaata 838801 aaaccgttaa ctagtggacc aacaacggga ccaacgtaag gagcaaaagc gaagaaagca 838861 atagccttac ctcttgtttc acttgggaac atatcggcaa tagacccacc aactaaacac 838921 aaaccagatg atgaccaaac accacataaa aatctacaag ctaaaagact acctagattt 838981 ggagctaagg cgcaagggat attgaagatg acataaagac ccatagaaac aaagtaagca 839041 actcttctac cgtaaagatc actaacagga gaccaaatca aaggacccag cgagaaccca 839101 ataaccatta aagaaaccga taaaatagcg gcttccatac ctacatggta tttcttttca 839161 acggttccca acccaccact gatacaagca gacccgtagg cgacacaaat aactaagatt 839221 gacagtagga cagtgtaact ccaacggatc catgcaggcc agttatgggg gttttctgga 839281 tcgccagtca caaaggtaac gaattcaatt tccggatcta gatctggagc ttcgtcattc 839341 gcaccactag agtcgccttc tttacccttt tcgttattat cactttctaa agcatcttca 839401 ttagaagaag gcgaagaagc gccatcgatc tgtctagttc tcgtacggga aatcgcagta 839461 gaagttctac ctatggaatg tagagtggcg acaggaacta aacctgtagg ggtttctaaa 839521 gtatattctt caggaaaaat cttattcttg ctagattgag gagcattaac atcaggaacg 839581 ggggctttgg agctcacacc catgtcctgc aatgacttca cggtttccgt ccgggtcaac 839641 ttcagttgat taggagccat gttggattta gatccactct ctgaagggat atattgttgc 839701 ggctgctgac tttctacatc agacaacgaa gatgtttcgt ctgaattaaa cgaatttatg 839761 gattcctgtc tgttcatttc tgtttatctt tggctagagg agtactaatg caaaattaaa 839821 ataatgaagt aagaagggag aaagtaatta gttatattag aaaactagac cacgaaattt 839881 gtagtataat tatgggtatg acaattaaag aattagggtg aacgctaccg gtgaggacaa 839941 aaaaggctga acgaagaaga aaaataaaaa gaagattaga tcaacgcacc tagacgaaaa 840001 agagcaaata ctgcttattg tattcacttt ggagaacagg ttgtaacagg acagctgaca 840061 attgctaagt taagtagatt acaaagacaa atgttcttag gcgaaaagaa tatataaact 840121 aaaagaaaaa gtggaaaaag ggtacgtgta aaaagagact aggatggttg agcagcgaat 840181 gattgcaaga tatataaaag aaacgagcca gttttacagc gtttaacgca gatccagaat 840241 atgaacaaaa tgcattagga aataaatgaa aaaaatggct ctatggatca gggatcatca 840301 tggctgccgg aaactacgcc gttctgtttt gtttttgttt ttcctttttc ccgtttgggt 840361 gaaatcagtg agctgttccg atccgttggg cgaagacatt gccgcagtga cgaagcccgg 840421 ctagtccgat tgggctccag taaacccctc gccaagcaca gagaagctag tcagaggccc 840481 gctagactgt acttactggt ctttagcaca cgacgaccgt actttgcacg tggctgcaga 840541 cacattttgt atggagggaa tgcttgatta tataaagagc tctgttttta tgttacccgt 840601 ccaacgttct cacccggctc cgcgctattt tttttttttt tttttttttt tttcagaccc 840661 acacaaaatc cgcgtagccg agattgctta tgtatgttat catattgcct gtttgagata 840721 tgcaggatca gcatagcatg tctctaacca aattgtgggt cagtcaatta tgttgctctt 840781 ttgggtatac gctttcaccg gattctcgag aaatcgtata atgcatgccc caaagcagtg 840841 gccgttctcg gaaaaataaa aatagtttat atctcaattt agttatatgg ctatgacgga 840901 aacgacaaaa tcaaattgaa acttagaaaa aataaaaaac agcgcattat taaggtttca 840961 tgactccgta ttcgctgtcc tacgtgtaaa taggaagaag aaaaaagtga aaaaggaaga 841021 acccttcttt tgaaggaaag cataactcgt tactcatacg acggatgcga gatatactct 841081 ctacgtagtt gtactagccg aatgaaaaaa gagaaagttc cgaatatgta aaattgaaat 841141 ttctcttctt tataatagaa ctaacaattg aactttcctt ttcttttgaa gctaccgtca 841201 atgacaaaga aggcagcttt gataaagtac tcaataggta aagcaaactt caattcagtt 841261 agcgaatgca ttgcgtacta gcgcgaatat tgttatggtt cttaatagta gatctaagcg 841321 tcatacgggc gcttgtcctt ccaccattga aagattatga tccgttagag cctttgatga 841381 aaagagacat ggccatgggt caacggaaca gattcaaagt cgacggccaa ttgccgccca 841441 tactaaattc cacagatgtg acagatgatc agagaagtct gcatacgcct ggagagattc 841501 catcttatgt catcaatcat tgtcccttag tgcacttgta tagcgaagag aaatattggc 841561 catcggacat tgctgagtac gttcaaaact tccaaattaa agataaaaac ggcaattcta 841621 tatccactca tgaaaatttg acactgcatg acttgaaggc ggaataccac gtagatttat 841681 ttggcaacaa aacggaaacg catatcccca gtagcgaggt atttttaacc agtttggacg 841741 atttcgacaa ggaccctaaa tggttgctcg gtcatctacc cgaatacgga acaggctaca 841801 actctaaggc gcctgctatt ctgatcgtag tcgacaaggg gaacgggtgg gttgatgcgt 841861 tctggttttt cttctaccca ttcaatcatg gcccttttat tatgggccat ggaccctggg 841921 gcaatcacgt cggtgactgg gaacactctt tggttcggtt ttataaaggt attccaaaat 841981 atctttggat gagtgcgcat tccagtggaa caggctacag atacgaagct gttgagaaat 842041 ttaagaaact acggaaaaga aaacagcaag atagtgacga tggtggggat actatactgg 842101 aaagaccgtt gatttttagt gctagaggca cgcatgctaa ttatgcatcc gctgggcagc 842161 atgctcatga cattcctttt tttttcatgc ctttgagtga ttttaccgat cgtggtcccc 842221 tgtgggatcc atctttgaac ttttactcct atacttttga tggtaaaact gtgacaccct 842281 cctcagagag agaagaatct ctcggtttgg attggttgca ttttcaaggt ggatggggtg 842341 atcaacaact accagctaga gatccaagac agaaatggtg cgtagctcaa tggaagtata 842401 tcggaggtcc tcgtggcccc ctgtttaaga aattggatag attgaatcta tgcggcggtg 842461 tgaaaaagtg gaatttctgg aatggtggct gccccgcaag aagattgata aaaaaagcag 842521 aaggcttgga ctctgagagc actgatctta tgggtgataa ttgtggtgtc ctactctata 842581 gaatcagacc aaaatggctg agaggaattc taagatttct aatgtggaga ggtatactct 842641 gttctcttat ggaatttttc accaattgaa gaactttatg acaacagaat gttctgattg 842701 taatataatg acaaatttta atctttagta atatctaata taatagttaa tgataaatag 842761 ttaattctaa tgtttaatga tctgcaaata ctttttatgt ttttcaacat agtttttaat 842821 gtgtttctac acttgatcgc aactaaatct aaataaacac acaagcacaa aatatgataa 842881 aaaagcaatt tggctagaag cacaggaacc aaatatgacg ttcaattcaa atagaccctt 842941 atttctggtc ttgttcatca gtccctgatg tcttgctctt tccttctgca attgatagcg 843001 ccacacttct caaaagcagt ggaaaaaaaa atcatttccc agaagaacgc gagagaactc 843061 catagaaaaa agggaacttt cctactcaaa agagaaaggg aaaaataatt gcgatatatc 843121 ttatagcctt tttttttttc caactttcta tttttgtaaa aatgaaaatt tccttcataa 843181 gctacaataa gactactcca tcccttgttt cctcaacgca ccgaactcga taggactggt 843241 cgtaaaacag aaaactgact aatggctgcc gcatgcattt gtcaacctaa tcttcttgag 843301 attaatgtat ctgatggacc actggatatg atccgcaaga aaagaaaaat acaacagccg 843361 caactacgtc caccccttcg agagaataaa tgccaaccac acttttctgt acgaaaggta 843421 aaccagtctt acataatttc tctccataaa gaaatcacat gccaactcat tgcagaaatt 843481 gtcaaacaaa agttatcgag gatttgggaa aaagtataca taccatctta tgaactgata 843541 tcagacaaag acggtaatca aatttatgtg gaacagagtg tcgacgaaaa taggctaact 843601 tctgagatta tggagaaact ggaccccaac aatattgata tagaggcgat cgaaatatta 843661 ttcgacgact atcacctaga attatcacgc ttgacaaacg gtattattat atctagtgcc 843721 aatgatcact tttacaggga attctccttc aataacataa ttgatgacaa ctttaaaatt 843781 tgtggaacaa gcatgtctgc agacagtttt gataagattt atggcgttat gtggattgaa 843841 gtacctttca atggcaatgg cttacagaat gatagcgccg ttaatagggt ttcaacatct 843901 cacaatcaga tagaagaatt gaatgacata gagcaggaga taagagcttt taatattagt 843961 cgaagtaatc aagaaagtat catcaaaaag gaagtatcta gaagattgaa tgggcggtaa 844021 gaaatacggg ctacggaatt taccgtgtgt cttcaaattg agtgtcaccc tgtaaggctt 844081 tctactctat cacaaaatat tacatattct aattctacaa ttatagatat caaacttgat 844141 aaatttagta gcaaatatga agtattatta tgcatttcaa aaaattccat tgtcccttct 844201 cttgggcgct tgaattctaa aaaaaattag cgcatcgcta atagcgcgtt tgaacccgtc 844261 ttaagaatgt tcataccagt atcaacaagg ggtatgttcc tcagcattat ctgaaggtac 844321 tcctctaaat ttttaagtaa gaaaaggcgt atagtcatat aattgttggg aatccaccac 844381 tgataaaggt tataatatca ggtaaagaaa ttgttggaat aaaaatccac tatcgtctat 844441 caactaatag ttatattatc aatatattat catatacggt gttaagatga tgacataagt 844501 tatgagaagc tgtcatcgat gttagaggaa gctgaaacgc aaggattgat aatgtaatag 844561 gatcaatgaa tataaacata taaaacggaa tgaggaataa tcgtaatatt agtatgtaga 844621 aatatagatt ccattttgag gattcctata tcctcgagga gaacttctag tatattctgt 844681 atacctaata ttatagcctt tatcaacaat ggaatcccaa caattatcta attacccaca 844741 tatatctcat ggtagcgcct gtgcttcggt tacttctaag gaagtccaca caaatcaaga 844801 tccgttagac gtttcagctt ccaaaattca agaatatgat aaggcttcca ctaaggctaa 844861 ctctcaacag acaacaacac ctgcttcatc agctgttcca gagaaccccc atcatgcctc 844921 tcctcaacct gcttcagtac cacctccaca gaatgggccg tacccacagc agtgcatgat 844981 gacccaaaac caagccaatc catctggttg gtcattttac ggacacccat ctatgattcc 845041 gtatacacct tatcaaatgt cgcctatgta ctttccacct gggccacaat cacagtttcc 845101 gcagtatcca tcatcagttg gaacgcctct gagcactcca tcacctgagt caggtaatac 845161 atttactgat tcatcctcag cggactctga tatgacatcc actaaaaaat atgtcagacc 845221 accaccaatg ttaacctcac ctaatgactt tccaaattgg gttaaaacat acatcaaatt 845281 tttacaaaac tcgaatctcg gtggtattat tccgacagta aacggaaaac ccgtacgtcc 845341 gatcactgat gatgaactca ccttcttgta taacactttt caaatatttg ctccctctca 845401 attcctacct acctgggtca aagacatcct atccgttgat tatacggata tcatgaaaat 845461 tctttccaaa agtattgaaa aaatgcaatc tgatacccaa gaggcaaacg acattgtgac 845521 cctggcaaat ttgcaatata atggcagtac acctgcagat gcatttgaaa caaaagtcac 845581 aaacattatc gacagactga acaataatgg cattcatatc aataacaagg tcgcatgtca 845641 attaattatg agaggtctat ctggcgaata taaattttta cgctacacac gtcatcgaca 845701 tctaaatatg acagtcgctg aactgttctt agatatccat gctatttatg aagaacaaca 845761 gggatcgaga aacagcaaac ctaattacag gagaaatccg agtgatgaga agaatgattc 845821 tcgcagctat acgaatacaa ccaaacccaa agttatagct cggaatcctc aaaaaacaaa 845881 taattcgaaa tcgaaaacag ccagggctca caatgtatcc acatctaata actctcccag 845941 cacggacaac gattccatca gtaaatcaac tactgaaccg attcaattga acaataagca 846001 cgaccttcat cttaggccag aaacttactg aatctacagt aaatcatact aatcattctg 846061 atgatgaact ccctggacac ctccttctcg attcaggagc atcacgaacc cttataagat 846121 ctgctcatca catacactca gcatcatcta atcctgacat aaacgtagtt gatgctcaaa 846181 aaagaaatat accaattaac gctattggtg acctacaatt tcacttccag gacaacacca 846241 aaacatcaat aaaggtattg cacactccta acatagccta tgacttactc agtttgaatg 846301 aattggctgc agtagatatc acagcatgct ttaccaaaaa cgtcttagaa cggtctgacg 846361 gcactgtact tgcacctatc gtaaaatatg gagactttta ctgggtatct aaaaagtact 846421 tgcttccatc aaatatctcc gtacccacca tcaataatgt ccatacaagt gaaagtacac 846481 gcaaatatcc ttatcctttc attcatcgaa tgcttgcgca tgccaatgca cagacaattc 846541 gatactcact taaaaataac accatcacgt attttaacga atcagatgtc gactggtcta 846601 gtgctattga ctatcaatgt cctgattgtt taatcggcaa aagcaccaaa cacagacata 846661 tcaaaggttc acgactaaaa taccaaaatt catacgaacc ctttcaatac ctacatactg 846721 acatatttgg tccagttcac aacctaccaa aaagtgcacc atcctatttc atctcattta 846781 ctgatgagac aacaaaattc cgttgggttt atccattaca cgaccgtcgc gaggactcta 846841 tcctcgatgt ttttactacg atactagctt ttattaaaaa ccagtttcag gccagtgtct 846901 tggttataca aatggaccgt ggttctgagt atactaacag aactctccat aaattccttg 846961 aaaaaaaaaa tggtataact ccatgctata caaccacagc ggattcccga gcacatggag 847021 tcgctgaacg gctaaaccgt accttattag atgactgccg tactcaactg caatgtagtg 847081 gtttaccgaa ccatttatgg ttctctgcaa tcgaattttc tactattgtg agaaattcac 847141 tagcttcacc taaaagcaaa aaatctgcaa gacaacatgc tggcttggca ggacttgata 847201 tcagtacttt gttacctttc ggtcaacctg ttatcgtcaa tgatcacaac cctaactcca 847261 aaatacatcc tcgtggcatc ccaggctacg ctctacatcc gtctcgaaac tcttatggat 847321 atatcatcta tcttccatcc ttaaagaaga cagtagatac aactaactat gttattcttc 847381 agggcaagga atccagatta gatcaattca attacgacgc actcactttc gatgaagact 847441 taaaccgttt aactgcttca tatcattcgt tcattgcgtc aaatgagatc caagaatcca 847501 atgatcttaa catagaatct gaccatgact tccaatccga cattgaacta catcctgagc 847561 aaccgagaaa tgtcctttca aaagctgtga gtccaaccga ttccacacct ccgtcaactc 847621 atactgaaga ttcgaaacgt gtttctaaaa ccaatattcg cgcacccaga gaagttgacc 847681 ccaacatatc tgaatctaat attcttccat caaagaagag atctagcacc ccccaaattt 847741 ccaatatcga gagtaccggt tcgggtggta tgcataaatt aaatgttcct ttacttgctc 847801 ccatgtccca atctaacaca catgagtcgt cgcacgccag taaatctaaa gatttcagac 847861 actcagactc gtacagtgaa aatgagacta atcatacaaa cgtaccaata tccagtacgg 847921 gtggtaccaa caacaaaact gttccgcaga taagtgacca agagactgag aaaaggatta 847981 tacaccgttc accttcaatc gatgcttctc caccggaaaa taattcatcg cacaatattg 848041 ttcctatcaa aacgccaact actgtttctg aacagaatac cgaggaatct atcatcgctg 848101 atctcccact ccctgatcta cctccagaat ctcctaccga attccctgac ccatttaaag 848161 aactcccacc gataaattct catcaaacta attccagttt gggtggtatt ggtgactcta 848221 atgcctatac tactatcaac agtaagaaaa gatcattaga agataatgaa actgaaatta 848281 aggtatcacg agacacatgg aatactaaga atatgcgtag tttagaacct ccgagatcga 848341 agaaacgaat tcacctgatt gcagctgtaa aagcagtaaa atcaatcaaa ccaatacgga 848401 caaccttaag atacgatgag gcaatcacct ataataaaga tattaaagaa aaggaaaaat 848461 atatcgaagc ataccacaaa gaagtcaacc aactattgaa aatgaatact tgggacactg 848521 acaaatatta tgacagaaaa gaaatagacc ctaaaagagt aataaattca atgtttatct 848581 tcaacaggaa acgtgacggt actcataaag ctagatttgt tgcaagaggt gatattcagc 848641 atcctgacac ttacgactca ggcatgcaat ccaataccgt acatcactat gcattaatga 848701 catccctgtc acttgcatta gacaataact actatattac acaattagac atatcttcgg 848761 catatttgta tgcagacatc aaagaagaat tatacataag acctccacca catttaggaa 848821 tgaatgataa gttgatacgt ttgaagaaat cactttatgg attgaaacaa agtggagcga 848881 actggtacga aactatcaaa tcatacctga taaaacagtg tggtatggaa gaagttcgtg 848941 gatggtcatg cgtatttaag aatagtcaag taacaatttg cttattcgtt gatgatatga 849001 tattgttcag caaagactta aatgcaaata agaaaatcat aacaacactc aagaaacaat 849061 acgatacaaa gataataaat ctgggtgaaa gtgataacga aattcagtac gacatacttg 849121 gcttagaaat caaatatcaa agaggtaaat acatgaaatt aggtatggaa aactcattaa 849181 ctgagaaaat acccaaatta aacgtacctt tgaatccaaa aggaagaaaa cttagcgctc 849241 caggtcaacc aggtctttat atagaccagg atgaactaga aatagatgaa gatgaataca 849301 aagagaaggt acatgaaatg caaaagttga ttggtctagc ttcatatgtt ggatataaat 849361 ttagatttga cttactatac tacatcaaca cacttgctca acatatacta ttcccctcta 849421 ggcaagtttt agacatgaca tatgagttaa tacaattcat gtgggacact agagataaac 849481 aactgatatg gcacaaaaac aaacctaccg agccagataa taaactagtc gcaataagtg 849541 atgcttcata tggtaaccaa ccatattaca agtcacaaat tggcaacata tatttactta 849601 atggaaaggt aattggagga aagtccacca aggcttcatt aacatgtact tcaactacgg 849661 aagcagaaat acacgcgata agtgaatctg tcccattatt aaataacctc agtcaccttg 849721 tgcaagaact taacaagaaa ccaattacta aaggattact aaccgacagt aaatctacaa 849781 tcagtataat tatatccaat aatgaagaga aatttagaaa cagatttttt ggtactaaag 849841 caatgagact aagagatgaa gtatcaggaa atcatctgca cgtatgctat atcgaaacca 849901 aaaagaatat tgcagacgta atgaccaaac ctcttccgat aaaaacattc aaactattaa 849961 caaacaaatg gattcattag atctattaca ttatgggtgg tatgttggaa taaaaatcca 850021 ctatcgtcta tcaactaata gttatattat caatatatta tcatatacgg tgttaagatg 850081 atgacataag ttatgagaag ctgtcatcga tgttagagga agctgaaacg caaggattga 850141 taatgtaata ggatcaatga atataaacat ataaaacgga atgaggaata atcgtaatat 850201 tagtatgtag aaatatagat tccattttga ggattcctat atcctcgagg agaacttcta 850261 gtatattctg tatacctaat attatagcct ttatcaacaa tggaatccca acaattatct 850321 aattacccac atatatctca gaaattttac tagaagttca ttatcctatt acttatcaat 850381 ccttgcattt cagctttcat taaatgtgct cactgtttct caatctttat gccatatttt 850441 tgcaccgtat acgataacat gcaaatagta cgaatactaa tcgatatgtg atggttgatt 850501 cttattccaa caattatctt gaacttcaat caactctcgc agttgtcacg tgcaatttga 850561 tacatgtcgc gttgatatac aagtactaaa tacggtacac aatggattat ttctgttgta 850621 tctcaaaatg agaaatgggt gaatgttgag ataattgttg ggattccatt gttgataaag 850681 gctataatat taggtataca gaatatacta gaagttctcc tcgaggatat aggaatcctc 850741 aaaatggaat ctatatttct acatactaat attacgatta ttcctcattc cgttttatat 850801 gtttatattc attgatccta ttacattatc aatccttgcg tttcagcttc ctctaacatc 850861 gatgacagct tctcataact tatgtcatca tcttaacacc gtatatgata atatattgat 850921 aatataacta ttagttgata gacgatagtg gatttttatt ccaacatacc acccataatg 850981 taatagatct aatgaatcca tttgtttgtt aatagtttga atgtttttat cggaagaggt 851041 ttggtcatta cgtctgcaat attctttttg gtttcgatat agcatacgtg cagatgattt 851101 cctgatactt catctcttag tctcattgct ttagtaccaa aaaatctgtt tctaaatttc 851161 tcttcattat tggatataat tatactgatt gtagatttac tgtcggttag taatccttta 851221 gtaattggtt tcttgttaag ttcttgcaca aggtgactga ggttatttaa taatgggaca 851281 gattcactta tcgcgtgtat ttctgcttcc gtagttgaag tacatgttaa tgaagccttg 851341 gtggactttc ctccaattac ctttccatta agtaaatata tgttgccaat ttgtgacttg 851401 taatatggtt ggttaccata cgaagcatca cttattgcga ctagtttatt atctggctcg 851461 gtaggtttgt ttttgtgcca tatcagttgt ttatctctag tgtcccacat gaattgtatc 851521 aactcatatg tcatgtctaa aacttgccta gaggggaata gtatatgttg agcaagtgtg 851581 ttgatgtagt atagtaagtc aaatctaaat ttatatccaa catatgaagc tagaccaatc 851641 aacttttgca tttcatgtac cttctctttg tattcatctt catctatttc tagttcatcc 851701 tggtctatat aaagacctgg ttgacctgga gcgctaagtt ttcttccttt tggattcaaa 851761 ggtacgttta atttgggtat tttctcagtt aatgagtttt ccatacctaa tttcatgtat 851821 ttacctcttt gatatttgat ttctaagcca agtatgtcgt actgaatttc gttatcactt 851881 tcacccagat ttattatctt tgtatcgtat tgtttcttga gtgttgttat gattttctta 851941 tttgcattta agtctttgct gaacaatatc atatcatcaa cgaataagca aattgttact 852001 tgactattct taaatacgca tgaccatcca cgaacttctt ccataccaca ctgttttatc 852061 aggtatgatt tgatagtttc gtaccagttc gctccacttt gtttcaatcc ataatgtgat 852121 ttcttcaaac gtatcaactt atcattcatt cctaaatgtg gtggaggtct tatgtataat 852181 tcttctttga tgtctgcata caaatatgcc gaagatatgt ctaattgtgt aatatagtag 852241 ttattgtcta atgcaagtga cagggatgtc atcaacgcat aatgatgtac agtgttggat 852301 tgcatacctg tatcgtacgt atcaggatgc tgaatgtcac ctcttgcaac aaatctagct 852361 ttatgagttc cgtcacgttt cttgttgaag ataaacattg aatttattac tcttttgggg 852421 tctatttctt ttctgtcata atatctgtca gtgtcccaag ttttcatctt caacagttgg 852481 ttgacttctt tgtggtatgc ttcgatatat ttttcttttt ctttaatatc tttattatag 852541 gtgattgcct catcgtatcg taaggttgtt cgtattggtt tgattgattt tactgctttt 852601 acagctgcaa tcaggtgaat tcgtttcttc gatctcggag gttctaaact acgcatattc 852661 ttagtattcc atgtgtctcg tgatacctta atttcagttt cattatcttc taatgatctt 852721 ttcttactgt tgatagtagt ataggcatta gagtcaccaa taccacccaa actggaatta 852781 gtttgacgag aattgatcgg tggaagttct ttaaaggagt ctgataattc ggtaggaggt 852841 tctggaggcg gatcgggaag tgggagatca gcgataatag attcctcggt attctgttca 852901 gaaacagtag ttggcgtttt gataggaaca atattgtgcg atgaattatt ttccggtgga 852961 gaagcatcga ttgaaggtga acggtgtata atccttttct cagtctcctg gtcgcttatc 853021 tgcggaacag ttttgttgtt ggtaccaccc gtactggata ttggtacgtt tgtatgatta 853081 gtctcattgt tactgtacga gtctgagtgt ctgaaatctt tagatttact ggcgtgcgac 853141 gactcatgtg tgttagattg ggacatggga gcaagtaaag gaacatttaa tttatgcata 853201 ccacccgaac cggtactctc gatattggaa atttgggggg tgctagatct cttctttgat 853261 ggaagaatat tagattcaga tatgttgggg tcaacttctc tgggtgcacg aagattgatt 853321 tcagatatag gttttgaatc ttcagtatga gttgacggag gtgtggaatc ggttggactc 853381 acagcttttg aaaggacatt tctcggttgc tcaggatgta gttcaatgtc agattggaag 853441 tcatggtcag attctatgtt aagatcattg gattcttgga tctcatttga cgcaatgaac 853501 gaatgatatg aagcagttaa acggtttaag tcttcatcga aagtgagtgc gtcgtaattg 853561 aattgatcta atctggattc cttgccctga agaataacat agttagttgt atctactgtc 853621 ttctttaagg atggaagata gatgatatat ccataagagt ttcgagacgg atgtagagcg 853681 taacctggga tgccacgagg atgtattttg gagttagggt tgtgatcatt gacgataaca 853741 ggttgaccga aaggtaacaa agtactgata tcaagtcctg ccaagccagc atgttggctt 853801 gcagattttt tgcttttagg tgaagctagt gaatttctca caatagtaga aaattcgatt 853861 gcagagaacc ataaatggtt cggtaaacca ctacattgca gttgagtacg gcagtcatct 853921 aataaggtac ggttgagccg ttcagcgact ccatgtgctc gggaatccgc tgtggttgta 853981 tagcatggag ttataccatt tttttcaagg aatttatgga gagttctgtt agtatactca 854041 gaaccacggt ccatttgtat aaccaagaca ctggcctgaa attggttttt aatgaaagct 854101 agtatcgtgg taaatacatc gaggatagag tcctcgcgac ggtcgtgcaa tggataaacc 854161 caacggaatt ttgttgtctc atcagtaaat gagatgaaat aggatggtgc actttttggt 854221 aggttgtgaa ctggaccaaa tatgtcagta tgtaggtatt gaaagggttc gtatgaattt 854281 tggtatttta gtcgtgaacc tttgatatgt ctgtgtttgg tgcttttgcc gattaaacaa 854341 tcaggacatt gatagtcaat agcactagac cagtcgacat ctgattcgtt aaaatacgtg 854401 atggtgttat ttttaagtga gtatcgaatt gtctgtgcat tggcatgcgc aagcattcga 854461 tgaatgaaag gataaggata tttgcgtgta ctttcacttg tatggacatt attgatggtg 854521 ggtacggaga tatttgatgg aagcaagtac cttttagata cccagtaaaa gtctccatat 854581 tgtacgatag gtgcaagtac agtgccgtca gatcgttcta agacgttttt ggtaaagcat 854641 gctgtgatat ctactgcagc caattcattc aaactgagta agtcataggc tatgttagga 854701 gtgtgcaata cctttattga tgttttggtg ttgtcctgga agtgaaattg taggtcacca 854761 atagcgttaa ttggtatatt tcttttttga gcatcaacta cgtttatgtc aggattagat 854821 gatgctgagt gtatgtgatg agcagatctt ataagggttc gtgatgctcc tgaatcgaga 854881 aggaggtgtc cagggagttc atcatcagaa tgattagtgt gatttaccgt agattcagta 854941 agttcctggc ctaaggtgaa ggtcgtgctt attgttcaat tgaatcggtt cagtagttga 855001 tttactgatg gaatcgttgt ccgtgctggg agagttatta gatgtggata cattgtgagc 855061 cctggctgtt ttcgatttcg aattatttgt tttttgagga ttccgagcta taactttggg 855121 tttggttgta ttcgtatagc tgcgagaatc attcttctca tcactcagat ttctcctgta 855181 attaggtttg ctgtttctcg atccctgttg ttcttcataa atagcatgga tatctaagaa 855241 cagttcagcg actgtcatat ttagatgtcg atgacgtgtg tagcgtaaaa atttatattc 855301 gccagataga cctctcataa ttaattggca tgcgaccttg ttattgatat gaatgccatt 855361 attgttcagt ctgtcgataa tgtttgtgac ttttgtttca aatgcatctg caggtgtact 855421 gccattatat tgcaaatttg ccagggtcac aatgtcgttt gcctcttggg tatcagattg 855481 cattttttca atacttttgg aaagaatttt catgatatcc gtataatcaa cggataggat 855541 gtctttgacc caggtaggta ggaattgaga gggagcaaat atttgaaaag tgttatacaa 855601 gaaggtgagt tcatcatcag tgatctgacg tacgggtttt ccgtttactg tcggaataat 855661 accaccgaga ttcgagtttt gtaaaaattt gatgtatgtt ttaacccaat ttggaaagtc 855721 attaggtgag gttaacattg gtggtggtct gacatatttt ttagtggatg tcatatcaga 855781 gtctgctgag gatgaatcag taaatgtatt acctgactca ggtgatggag tgctcagagg 855841 cgttccaact gatgatggat actgcggaaa ctgtgattgt ggcccaggtg gaaagtacat 855901 aggcgacatt tgataaggtg tatacggaat catagatggg tgtccgtaaa atgaccaacc 855961 agatggattg gcttggtttt gggtcatcat gcactgctgt gggtacggcc cattctgtgg 856021 aggtggtact gaagcaggtt gaggagaggc atgatggggg ttctctggaa cagctgatga 856081 agcaggtgtt gttgtctgtt gagagttagc cttagtagaa gccttctcac attcttctgt 856141 tttggaagct gaaacgtcta acggatcttg atttgtgtgg acttccttag aagtaaccga 856201 agcacaggcg ctaccatgag aaatgggtga ataattagat aattgttggg attccattgt 856261 tgataaaggc tataatatta ggtatacaga atatactaga agttctcctc gaggatatag 856321 gaatcctcaa aatggaatct atatttctac atactaatat tacgattatt cctcattccg 856381 ttttatatgt ttatattcat tgatcctatt acattatcaa tccttgcgtt tcagcttcct 856441 ctaacatcga tgacagcttc tcataactta tgtcatcatc ttaacaccgt atatgataat 856501 atattgataa tataactatt agttgataga cgatagtgga tttttattcc aacacaaaat 856561 gagatatgtc agtatgacaa tacgtcatcc tgaacgttca taaaacacat atgaaacaac 856621 cttataacaa aacgaacaac atgagacaaa acccgtcctt ccctagctga actacccaaa 856681 agtataaatg cctgaacaat tagtttagat ccgagattcc gcgcttccac cacttagtat 856741 gattcatatt ttatataata tataagataa gtaacattcc gtgaattaat ctgataaact 856801 gttttgacaa ctggttactt ccctaagact gtttatatta ggattgtcaa gacactccgg 856861 tattactcga gcccgtaata caacaattta caacaagatt cgggcgtgtg gcgtagtcgg 856921 tagcgcgctc ccttagcatg ggagaggtct ccggttcgat tccggactcg tccattttaa 856981 tttttgatta tggaatacaa aatgtatatt tcgtataaaa ttatctttat tgtttttgtg 857041 gcttagtgat tttcattccc ctcttttctt tttcctctca gcctgcaagt gtgacgcgat 857101 ctgaaaggcg ttttacccgc aaaacgccaa agaatcatcc tgaagcggta aattctagac 857161 ttcagatcac atacgctcta tttggacagt tttttttttt ttttcatatt cctgatcaga 857221 tgaaagttaa cgctattttt ggtgaaaaca cagaataaaa cagcttctga taaaatttaa 857281 ctaggaacgt cgaaaacaac aaccgttaaa atatttttag cttacagaag cacttaagaa 857341 tcactaacgt tttcttcttt ttttattttc agtccaaagc tttcgtattg ctgcaagtgc 857401 tcgagaaagc tgcatattgt tattgtattc gtcctctcgt actagtgttc attactttat 857461 cgtctataaa tatattgttg ttagaatttt tctactaagg caagttagta gttgcacaac 857521 atttctctcg ttaaatcatc taaagtttac agaataggta taccactcac tcctttactc 857581 taatgccttt gagaaatcta actgaaacgc acaactttag tagcacaaac ctggacacag 857641 atggtacagg cgacgatcat gatggtgctc ctctttcctc atctccttct tttggacaac 857701 aaaatgacaa tagcaccaac gataatgctg gtctcacaaa cccttttatg gggagtgacg 857761 aagaatctaa tgcgcgggat ggagaatctc tgtcttcttc tgttcattat cagccacagg 857821 ggagtgactc ttcactactt catgacaatt ctcgtctaga tctaagtcaa aataaaggtg 857881 tatctgatta caaaggttac tattccagga acaatagtag agctgtgagt acggctaatg 857941 ataactcatt tcttcagcca ccacatagag ctatagcctc ttctccttct ttgaattcta 858001 atttatcgaa gaatgatatt ctctcaccgc cagaatttga tagatatccc ttagtgggtt 858061 ccagagtcac ttctatgact caactgaacc atcatggtcg ctcgccaaca tcatctccag 858121 gaaacgagtc gtccgcctca ttctcttcta atccgttttt gggcgagcaa gatttttctc 858181 catttggtgg gtatcctgct tcatcgttcc cacttatgat agatgaaaag gaagaagatg 858241 attatttaca caatcctgac cccgaagaag aggcaagact ggatagaagg aggttcatag 858301 atgacttcaa gtacatggat aaaaggtctg ctagtgggct agctggtgta ttgctcttgt 858361 ttctggcagc catctttatt tttattgttt tgccagcgtt gacctttacc ggtgctattg 858421 atcacgaaag caacactgaa gaagttacat atttaactca ataccaatat cctcaactat 858481 ccgccattag aacatctctg gttgacccag acacacctga tacagcgaag acaagagaag 858541 ctatggatgg ctctaagtgg gaattagtat tttctgatga gtttaatgca gaaggcagaa 858601 cattttatga tggggatgat ccatactgga cagcccctga tgttcactat gatgctacta 858661 aggatttaga atggtacagt ccagacgctt ccacaactgt gaacggaacc ttgcagctga 858721 gaatggatgc ctttaagaac catggcttat attacagatc aggtatgttg cagagttgga 858781 ataaggtttg tttcacgcag ggtgctctag aaatctctgc aaatctacca aattatggcc 858841 gtgtttcagg tttgtggccc ggtctttgga ctatgggtaa tttagggagg cccggttatt 858901 tggctagtac ccaaggtgtc tggccttatt cttatgaatc gtgtgatgct ggtattacac 858961 ccaaccaaag ttccccggat ggtatttctt acttgccggg acaaaagtta agtatttgta 859021 cttgtgatgg tgaagatcat ccgaatcaag gtgttggtag aggagctcca gaaattgatg 859081 ttttggaagg tgaaactgat actaagattg gtgtaggtat agcctctcaa tccttgcaaa 859141 ttgcaccttt tgatatctgg tacatgcctg actatgattt tatcgaggtt tacaatttca 859201 caacaacgac catgaacact tatgctggcg gtccatttca acaagccgta tctgctgtct 859261 caactttgaa cgtaacttgg tatgaattcg gtgagtacgg tggctacttt caaaaatatg 859321 ccattgagta tctgaacgat gacgacaatg gttatatccg ttggtttgtt ggtgatactc 859381 caacttatac tattcatgct aaagccttac atcctgatgg taatattggt tggagaagaa 859441 tcagtaaaga accaatgtcg attattctaa atctgggtat ttccaacaat tgggcttata 859501 ttgattggca gtatattttc ttcccagtgg ttatgtcgat tgactatgtt agaatatacc 859561 aaccaagtaa tgctatatcc gtgacatgcg atccaagtga ctatccaaca tatgattata 859621 ttcaatcgca cttaaatgca ttccagaatg caaacttaac tacttgggaa gatgctggtt 859681 acacgttccc taagaatatc ctaactggta aatgtactag ctcgaagttc aagttatcct 859741 cttaagcggg tattttgatg gtaaatctac aagccctcgg ctttaattat taccatggtc 859801 ataaaaagtt acttacaatg catacatttt tcttttagga agaaataaaa tataaaagac 859861 ttatcgttca aatcgggtca taaagggaac taaaggtata ctaaggtaag acggggttct 859921 catctgcacg taatttttta ttatttttag tgagggagaa ctttacctct aagattgttt 859981 atataggtat acacattttt gtaaaactga ttattcgttt ttttttttga aacaagttat 860041 tagtacaaaa atcaagctct cactacttac cagtagttat tttagtagaa tattattaac 860101 tctaccgaat aagtacgata tgagaaattg ctgatttact tgtgtgtgtt cctattatta 860161 tccaggagcg cctctaatct atgcttataa ttttacgttg aaaaaaaagg agtctgtata 860221 attatttcaa attcatcctt ttctcacgga tattgtgtac cctatgaggt aaataattgc 860281 gctttatttt ctccctgtgt ttgctcgctc atcttaagac gaaaaaagta atggaacacc 860341 taccatcaat agaagtacca cactcatgta aataacaagc gcaagtggtt tagtggtaaa 860401 atccaacgtt gccatcgttg ggcccccggt tcgattccgg gcttgcgcag attttatttt 860461 ttgctccctt ctaaagctct ggatgattca ccaacttatc caaggcaagg tccaactacc 860521 gtttccttcg atgaaaaaga caataggtag ctctgtcaaa ccccgtggaa acgcaaactc 860581 atcgggagtg tcctactgct ttccactagt tatccgacta gcaaggcaac tagtcaagat 860641 gaaaccgtct cacgaacatt tgtatacgat ctcttctcct gatagacaat gaaatatacc 860701 ccggtgcttg tttcccacta aggaaaaaag gccgctgccc cacagcggga aggcccttca 860761 aggggtagcg gcatcgccta gtagcactgt ggggggaaga atacaacgct caacggaaga 860821 ggaagctctg cgagatgcag ccagcacctt ctatgtttca aggataacat tttgaattaa 860881 caaggaacgc cttccccaat taccgttatt gtatttttac tttttagaga ctctcgagga 860941 aataagtaag gggtggataa ttttcgctaa aaaagtttca ggggaggtta ataactacca 861001 tgtgcatgct acaaagataa ggaaggaaca ccgacgaata tattatatgt ataaaaggag 861061 catgaagttt gtatagcagt aaagcaagat tctttgtgcc ttcccgtttc ttgttgtacc 861121 ttttgttttg attacgtacg aagtattata agttttttct gcttgctatt gtaatataaa 861181 gtaagcacag attgagaagg taacgattac taaaaatatc caaaagaaaa acaattggat 861241 cttttttgac ttctctacat tacaatttca gtaaagcagc tttcaactta atttaatttt 861301 gaacaatgcc gccagctagt actagtacta ccaatgatat gataaccgaa gaacctactt 861361 ctccacacca aatcccaagg cttacaagga gacttacggg gtttcttccc caagaaatca 861421 agtcaattga cacgatgatt cctttaaagt caagagcgtt atggaataag catcaagtca 861481 aaaaatttaa caaggcagaa gattttcaag atagattcat tgaccatgtg gaaactacat 861541 tagcacgttc cctatataat tgtgatgaca tggctgctta tgaagctgct tcgatgagta 861601 ttcgtgacaa tttggtcatt gactggaaca aaactcagca gaaattcacc acaagagacc 861661 caaagagagt ttactatttg tctttggagt ttttgatggg tagggctttg gataatgccc 861721 tgattaatat gaagattgaa gatccggaag accctgctgc ctcaaaggga aaaccaagag 861781 aaatgattaa aggggctttg gatgatttag gtttcaagtt agaggatgtc ttggaccaag 861841 aaccggacgc aggtttaggt aatggtggtc taggtcgtct tgcagcttgc ttcgtcgact 861901 caatggcaac ggaaggcatc cctgcctggg gttatggtct acgttatgag tatggtatct 861961 ttgctcaaaa gattattgac ggttaccagg tggaaactcc agattactgg ttaaattctg 862021 gtaatccatg ggaaattgaa cgtaacgaag tgcaaattcc tgtcaccttt tatggttatg 862081 ttgatagacc agaaggcggt aaaactacac tgagtgcgtc acaatggatc ggtggggaaa 862141 gagttcttgc tgtcgcgtat gatttcccag ttccgggttt caagacttcc aatgtaaata 862201 acttaagact atggcaagca aggccaacaa cagaatttga ttttgcaaaa ttcaataatg 862261 gtgactataa aaactctgtg gctcagcaac aacgcgcaga gtctataacc gctgtgttgt 862321 atccaaacga taactttgct caaggtaagg agttgaggtt gaaacagcag tacttctggt 862381 gtgctgcatc cttacacgac atcttaagaa gattcaaaaa atccaagagg ccatggactg 862441 aatttcctga ccaagtggct attcagttga atgatactca tccaacttta gccatcgttg 862501 aattacagag agttttggtc gatctagaaa aactagattg gcacgaggct tgggacatcg 862561 tgaccaagac ttttgcttat actaaccaca ctgttatgca agaggccctg gaaaaatggc 862621 ccgtcggcct ctttggccat ttgctaccca gacatttgga aattatatat gatatcaact 862681 ggttcttctt gcaagatgtg gccaaaaaat tccccaagga tgttgatctt ttgtctcgta 862741 tatccatcat cgaagaaaac tctccagaaa gacagatcag aatggccttt ttggctattg 862801 ttggttcaca caaggttaat ggtgttgctg aattgcactc tgaattaatc aaaacgacca 862861 tatttaaaga ttttgtcaag ttctatggtc catcaaagtt tgtcaatgtc actaacggta 862921 tcacaccaag gagatggttg aagcaagcta acccttcatt ggctaaactg atcagtgaaa 862981 cccttaacga tccaacagag gagtatttgt tggacatggc caaactgacc cagttgggaa 863041 aatatgttga agataaggag tttttgaaaa aatggaacca agtcaagctt aataataaga 863101 tcagattagt agatttaatc aaaaaggaaa atgatggagt agacatcatt aacagagagt 863161 atttggacga caccttgttt gatatgcaag ttaaacgtat tcatgaatat aagcgtcaac 863221 agctaaacgt ctttggtatt atataccgtt acctggcaat gaagaatatg ctgaagaacg 863281 gtgcttcgat cgaagaagtt gccaagaaat atccacgcaa ggtttcaatc tttggtggta 863341 agagtgctcc tggttactac atggctaagc tgatcataaa attgatcaac tgtgttgctg 863401 acattgttaa taacgacgag tcaattgagc atttgttgaa ggttgtcttt gttgctgatt 863461 ataatgtttc taaggctgaa atcattattc cagcaagtga cttgagtgag catatttcta 863521 ctgctggtac tgaagcgtct ggtacttcta atatgaagtt tgttatgaac ggtggtttga 863581 ttattggtac tgttgatggt gccaatgtgg aaatcacaag ggaaattggt gaagataatg 863641 tcttcttgtt tggtaaccta agtgaaaatg tcgaagaatt gagatacaac catcaatacc 863701 atccacaaga tttaccatct agtttggatt ctgttttatc ctacattgaa agtggacaat 863761 tttctccaga aaatccaaat gaattcaaac ctttagtcga cagtattaag taccacggcg 863821 attattacct ggtcagtgat gactttgaat cctatctggc cacccatgaa ttagtggacc 863881 aggagttcca caatcaaagg tcagaatggt taaaaaagag tgtcctgagc gttgcaaacg 863941 tcggcttctt tagcagtgat cgttgtatcg aggaatactc cgataccatt tggaacgttg 864001 aaccagtgac ttagctggga gtttttttta tctctttggc acccttctcc ccatttctag 864061 taagcgcttt tttctcttta cttcttctct tatataaaac gcctttaaaa taatcgttat 864121 cggttttttg gcactctttt aaatggtata tatgatgtta caggaaaact tagttgtttt 864181 catattgaaa atccgcgcag gataacgctt gtgtaaaacc gagtgtcctg aaggtgggta 864241 aggcggtcct tattatcact tactcgaacg ttgacattgg tacagtccct atcaggtagg 864301 atgtactgac gttttgacaa tagtttcgat tttatggatt gtttgaaaag agcgagacag 864361 tgacaaaacg tgatagatta catagtagtc agtatacaac tttccgtaat tagccacgag 864421 gccagaaagg aagagagaat agtataacct aatatagatc tgcaatatca ctattttgga 864481 actccttaga ctcatctggt ttcgctcttt catccttaaa gcttccattt tttttctcta 864541 ttggtttact cgtaagctga tgctgcccct gtgagggcga gattgggaat tgtggatgag 864601 aaggtctcga gccttgatga tgatcaccag ccatattgcg agaaccgttt gaaggattat 864661 aatttttatt gattggcgca ttggattctt ggcgactata tttctgtggt tgcctattga 864721 agttggtttc cggcttgttc acgtacctag ggttatgata tctagagtca tttggcgagt 864781 ttttgtaccg ggactcattt gaattaccct ggtatcttga ctgaggcccc aatggcaaag 864841 gtactttatt atatttagag ctgacatttg tctcaggatg aaatcgattt acgggattcc 864901 tgctgttgtt gggtgcagtg ctgttgccgc tgaagcgatt atttctggaa ctattgttgg 864961 gtccgtatct attaactcct gcaggggctg ctggcggtgg aatcgcagtt ttagcatatc 865021 cgctgttcac atgatacggt ctaggatttt gatgtagttc tcttattttc gaaggaggcg 865081 gcttagccaa tacgttcttt gatggaggca aaaaacttgc gtcatctttc ttggggcctc 865141 ttgggatcgc cccaagattt ttcacgacag gtgattcacc cttttcaact atatgacctc 865201 ttggcgcagt aggtactctt tgggacaatg attggtgcat ttcttccttg tacctcttaa 865261 tatcagcttc atgactttct tccgtcggta atgttatctt ctctgatggt aaagggtcct 865321 ctttaaacca aggatggtgt ttagcagaca tagcggtcaa cctcttgtaa ggatctaacg 865381 ctaacaactg tcctaaaaaa tctagacctg tttcacttag atatttacca aatctttccc 865441 tcaacgttgg cttgtaatta gttgttgtta gttcagcacc tggcaaatat ctagccacgg 865501 cccaatcttc ttctgtcggt gtaccaagta gtttgaaaat aacatgtccc tgatcaatat 865561 ccgtttttcc ctgtaaaata ggttttttct caaaaaattc tgcgaaaacg catccgacac 865621 cccatatatc aacagctgtt gtatactgtt tatcaccaag caccaactca ggtgctctat 865681 accatctcgt tacgactact gatgtatatt tggcgccgga acctgcacca ccaggatact 865741 ttaagtttgg aggacagcca taatataatc ttgctaaacc aaaatcagca agctttaaaa 865801 caccgttgtg gtcaatcaaa atatttgctg tctttatatc cctatgcatg aattttgcac 865861 aatgaatata atttaggcct tctaatattt gtagcatcat attctttata tcgcacatct 865921 ctaagttgat tctcggatta tgcaaaacgc ccgacagatc tgctaccata tacggcagga 865981 tcatgtagaa tgacttatgt aggttgctgg atgccgcatt tgtaatatcc ggtgaatggt 866041 catacaccat ttcgattagt ttaataatat ttttgtggtt taaacgcttt aaaatagtaa 866101 tttctcgttg tgcagttata ggaaacagat ctttttcaac gctaactata atttttttca 866161 ttgccacttg tctttgagtc tctaaatgaa ttcccttata aacctcacca aatgttcctt 866221 gtcctaattt ttcatcctca cgataatgat tctggaaaac tgtacacccg taaactttct 866281 cactacttct ttttcttagt ttgatgtatg ttaagttagt cttcgcatct cgctggatgg 866341 ctggtgtact cttcactttg ccgattttgt atttattaaa ttcggttttt ggaagaaccg 866401 cgggggaacc attatcactc atattatttt actgttattc tgcttgacca cgaatgtact 866461 gctaatacta tacaatttct tttgctggtg tttggtaata tttcttttca ccattgttaa 866521 tttctctctc tacattgcct atgctctatt aaatgcatat gtgaattttt caaattcaca 866581 gaggtttggt gtatgggtgt atttccgttc gacgcgatga ccacataatc ttgaacttac 866641 ttattaggaa agctgaacag tggaatatca gagttgctac cgccaataaa atgtctgtat 866701 attgttccca agattcacag ttgtgtccag gagtagtaca tattagattt ggggataatt 866761 cttcttaatt cctgaagaat gatctgcatc tggtaacttc tcaagtcaaa cgggatcatg 866821 gtgccctgaa attgataatt gctagcgtaa aatgctgcgg tcgcattatc tctcaaacca 866881 acggctgatt tctcggtaaa aaaatccagt tgcactaaat tttcccaaac gttcttgacg 866941 tcctttttca accatagttt gatagtattg tcgatagaaa aagtactttg acctgttccc 867001 acatttgtag taggagccac ggtgggaatt ctggagttga tagctttaat catcttttca 867061 tactctgcat aagctaaatt aaaattaaaa gatccgtctt tcgcccttaa ggcaacccta 867121 gcggctgaga tcaaaatggc taactctaaa tcggataaag attggagcct tcctgttaaa 867181 ttattagata gttggttctt attgtatatg tcaagaaaag aacacgattt tatggcagtg 867241 cagagtgaac caaaattttt ggatgtcgct actaatggaa ttatgctatt tttcaatgta 867301 ggtaatgacc taaaggtttc gaaattcatc ctaatatgtc tattcaaatt cgatcgaggg 867361 tcggatagtt ctttttccaa cgtttcattc cattgtgaaa cccaggggga gatttcagag 867421 cgaactgtaa gtaaatttct gacggcgtca accatatcgt ctagattctg tatttgcggc 867481 atataaatca ctctttgaga aaatctactc tttaccctct tttctaaata ttccaagata 867541 tttaatttcg ttgtgcagcc aaaaatgcaa acaggtaccc gagaatgttc taccatgtca 867601 aaaagattgt ataataaagt ttgcctcaca ggcccagcaa atgtatcaat ttcatcgaat 867661 ataaaaacaa ctgttatctt tgttatactc tctctgtcaa cctcaccact atcttcattt 867721 cttgtcttcg tggtcgaatc taagagtaaa agaattttct caaacacttc tgtcaaagaa 867781 ccactgctaa tagtctctaa tgaagtatcg tcaatttttt cttcactgcc atgaattttc 867841 tgcaactgct gttccaattg agttgctata ccgttaatag ctgtttgttc ggagtgaata 867901 aacccattca acctgatagt tataaactgc tctttataag attgttgcaa caaagacagt 867961 tcatagtcta ataagtatgt tttgtaactt tgtctgggcc ccacgagaat tactgaatga 868021 ctctctttct gaataatgga ttgtttaatg attctatcga tctcttgttg acaatcttgt 868081 aaatatgtga agattatctt ttcgtccgta ggaagtgtgc cataaagttg ctgcagtaac 868141 cttctttgaa gggaaccaaa accagggtcg ctgtctttac acttttcatt atctatagta 868201 cgctttttta gaatcgctgc agtctcctct acctcttcgt ttgagtgcct ctttattggg 868261 agaagattga cttgcggtga tagacgagct tcgcttatag tcatgcttct tcttttgaat 868321 attaccgata ttagtagttt atatttgata tttctatcag tattatttag attttttttt 868381 tttttttaat tgttaatgct ttttcttaga actttccaaa aacgaaagga aaatgggaca 868441 ttcaaaaact tacctcacat agaaaaatga taaatccaaa aatacacttg aacacatgta 868501 tgaaacttaa tacaaaatat atggttattt tttttttaat tatataatag agttagaata 868561 cctggtagaa aggagagtag aaaaacaaga aagaaaaaaa gcaaacagta aatacaaatg 868621 tacattttat catcatacaa cactctattt cttaccaaca acttcccaat tgtcaccatc 868681 ttcaacagtc aattgagcag ttttatcctg tagcttttca actgccgcat caactttgtt 868741 ttcttttgcg tctccatttt gcttttcagc ctcttcatct tcatcatcat cttcagtacg 868801 taaaacatca taaacagact tctggatttt tggttgctca tcagtagtct ttttgttagt 868861 tagagaccta tccttgtagg tatttttggt ttgttgaggc ttaccaaact gagcacctct 868921 ggcagcaccc caatccaaag ctggttcttc cttttctctt tctcttcttg gtggtcttga 868981 ggagctttgg aagttggaac ctctggctgc actccagtca atatctggct cttctctttc 869041 tcttcttggt ggcctcgagg agctttgaaa gttagagcct ctagctgcac tccagtcaat 869101 atctggctct tctctttctc ttcttggtgg tctggaagag ccttggaaat tggagcctct 869161 tgcagcgctc cagtcgatat caacttcttc tctttctctt cttggtggtc tggaagagcc 869221 ttggaaattg gaacctcttg cagcagtcca gtcaatatca acttcttctc tttctcttct 869281 tggacctctg aagttagaac ctctagcggc accccaatca agatctggtg catcttctct 869341 tccatcacct tggaaattgg agcctctagc actactccaa tcaacatctg cacctccccc 869401 tcttcttgga gccgcaacag aaacgtaaac agttctctca ttcaatttag taccgttgaa 869461 cttcagaacg gcgaccaaat ctgctctttc tttcaaagta acgaaagcat taccctttaa 869521 tcttgttggg tctcttagat tctttggcaa aacaacttct tcaaccgctt caggcttaac 869581 taaaccatct tcaacccagg cttgaacacc ctctggggta atatcccatg gaatgttgtt 869641 tatgacagcc ctatatggtg gagcatctgg aacagggtat tcctctcttc tatcggaaga 869701 accgcccccc aaagcagggt ctaatctaga tctacctcca aaactgccac caaagccgcc 869761 tgaacgcgtg ttattgctgt tgtttttagc atgagccaat tcggacaatg gaatagtgtt 869821 tgcattagcg gtttcaatag gaattgtgat cttattcaaa tcgacatctt cttcagccca 869881 agatgaacca aaggtgtcat catttaaaaa tgacgtaagg tccatcttct ttacggtttt 869941 ctttggtgga gccatgatgt gtccttttta ttatggtatt attttcctaa agacagatga 870001 aagctaatat aaactcgagt tttatgataa tcccgcttat tggtctactg atcttctcta 870061 actctgtagt tatatctatc tcttctgctt ctatttctgc ttttctttag cgatgctgat 870121 ttccgcaaaa aaattttcat tccgtggtgc gtgatctgat gagaaataaa gccaaaaaga 870181 aaaaaagaca agaagacaaa aaggttgggc ggctaagtag cgccaggata taaaaagcaa 870241 catagatttc agtaccctat tatcctgcca aaatttactt taagaagtct ctatgaatat 870301 acaggctaaa tttggaaaca tgagaaagga aagatgaaga tacaaagatt gcaagcagtc 870361 aagaagattt aggaaaaaag gaaaaagcaa aaaatatcga tttttatgac ttacaaacta 870421 aattgatatg ttcgaaataa ttttgagaag ctgagctcaa tctggtacta atcacttcaa 870481 gttagatgtg caaagaaaga gaatagcata aattcaaaac caaaggaagt gcgaggcatt 870541 acccgcatat tatcgggaaa cagaagccat gttagagtga tttccaacaa atggcccttt 870601 gccagagatg ggctctgcaa aagaattgga agaagagaag aaatcgcttc acattccgtt 870661 tcgtttctgg gtctaattaa agtagtacgg tgtcaattag gtatgctagg tttgcgaact 870721 catggtttag acaggtatga acattatatt cgtcgcccgt cggattttgg caaacttgag 870781 ctgcaagatt ggttgaatca taagtcattc cgagtttccc ccaatttatt aattgattca 870841 agcaccacac gtgagtggaa tgaacctgag cttttttatc aaaataccga ggatgaaact 870901 tgggtgagac cttgtgtagg gccaaagcta gaaccatcaa tgatgatgct cagatatcac 870961 gattcgaata ttggtcaaat gcctcaattt tgttatccaa tctcaagtcc gataaatttt 871021 aaaccagtat taaaatacat tttgcaagaa cgttctgaac tgtcagacgg cttccctcaa 871081 aagtataaca cactaatagg tagtcttttt gacattgata aaaacccaga aaccttagat 871141 gattcagata tagaagcatt ggatgacata gaaatgagca gtgacagcgg taatgttaaa 871201 gaaccaaaaa ttgaattgca ggcgctggaa gaaatccaac aaaagcattt cagtttaata 871261 gtatccaaca atggaatctt tcaaacaggt agcacttcaa taacatacat acagtctggc 871321 atatctggca gcatagctat aaaacccaac aacgttgcaa ttttaatatt actcactcaa 871381 ccaagtggtc acttattgtc tattttaccg cttgatgacg gtaaagagac atatttgcta 871441 caatattgga acctgggaca aaaaggtcag tggaacataa tcaagcacca aaacgagaag 871501 cagtttgttc ttatacataa ggaactaggc atttgcaaat tttttgaatt ccatttacca 871561 tttacttttc aattagtaaa caatttaaca ttgaccgatt ccgtgattat gaacggatcc 871621 tttttcccaa caaattacac tgatttagat ccctatttca ttatatttat aacagccata 871681 agatatgaaa ggatagtcta ctttgtcata gaatggaaca acaacgaaat aaagaaaaaa 871741 gaggtatatc aattgacagt atttgatggt gagaagacta atatgacaat acccattgga 871801 ctaaatgcat gtttagtcga aacaccccta aagttctctt tagtttctgc aaatcaaatt 871861 atgtcaggag agactgaatt ccactcattc caattgaagg ctctcaaggg aatcaagtca 871921 ttttttccag ctcctttatt gttattaaaa ttacaagaac tacacccaca tacatttaaa 871981 aaattccaat attgtaccat aatatcctcc tcgacaggaa atatttgttt ttgcgtcacc 872041 gaacgatcga caatagtaaa tggtaattta aaattttacg agctaactag gttcaaagga 872101 ttgaaatcca tttcaccact accttcaaat ccgataaatt tagactccag atcctcaagt 872161 tatgtactgg tggtcataag ttttagtaga acattagagc taacattatc tctagaagat 872221 ttgagatgtt tagataaaaa agacgttatt aagcctttga aaaatatcac cttcaagcac 872281 acaattgata gttccacaga ggagaactct caaattttag catttacgtc ttctaaattt 872341 tataacacac acacaggctc taacatcaat gacacgagaa attctcaagt ttggcttacc 872401 tcaccaaatg caataactca accttgcatt gattataaac tcaggaaaac tcatcaactt 872461 atccacttaa agcaatttca aatttttaga catcttagga tatggaaatg taagaacctt 872521 gatattgctc tgttacagag acttggaata aaccagtcaa ataccgaaag ttcgttaatt 872581 tttgcgaccg acgctgtttc taacaacaga atatttttat tagatttaac tatgacaacg 872641 acaatcgata atgatgatcc cgttcaagga ctgataaata tagaagattt actatgtgat 872701 actgaaaacg aaactatcct tctaaatttt acgaaaaata acttgattca agtaactagg 872761 gatacgatat acatcgatcc cattggtggg gacaaagagt tgcgtaagat ttctccaggt 872821 tgggaattcg aaaacgttac atacaatgat ggtattttaa tagtttggaa tgctgggctt 872881 ggctgtgtct cttatattga aaatatagac gctgttgatg agtctggcgc cttagtttca 872941 aacttaagca gcagcaaagg catgagcaag ttcttcaagc agttaggaac tgtcacgagt 873001 gtcaattttc aaatcaaaga gtctacagat gatccaacca agtatgacat ttggatcctt 873061 ttaccagact gtgtcattcg tacacccttt tctgactgga ttagtgattc acttgatttt 873121 tctgatgtgt atattttgag tgttcagcag gcgttaataa acggccctta tttttgctct 873181 ctcgattatg aatcatattt tgaggtgcac actttacaga acaactgctt caaaaaagga 873241 tccagatgta caagcagagt taattttcaa gggaaagata ttaaatttag aagctttggt 873301 gtgaatcaat gtttggcatt tagtgcattt gaaatttttg tcatcaattt aacgccaatt 873361 cacgacagta gagaattgga tttttacaag ctaaaattac cgcacctagg taataacaat 873421 tcaattcttg aagtctgtcc ggacatagaa aacaaccaat tattcatact ctactctgat 873481 ggcttaagaa tcctcgaact atcataccta acatcaaata atggaaattt cttattaaaa 873541 tctacaagaa gcaaaaataa gaaattttta tatctagaca aaataaatcg aatgctggta 873601 ttgaatcagg acttgaggga atgggagtgt attagactat cagatggtaa ggcagttggt 873661 ttagattctc aacttcttaa ggatgattct gaagaaatcc tagaaataaa ggaattacca 873721 atagcaacag aggacaatcc tttagaaaag aaaactgtat tattgatctc ttttactagc 873781 tcattaaaac tagttttatt aactgctgca aaaaacaaaa tttccaatca aataatagat 873841 tcgtataaac ttgacaattc aagactcctc aatcatttgg tcattactcc cagaggtgaa 873901 atattctttc tggattataa agttatgggc accgataacg aaatgtcctt taacaagttg 873961 aaagtcacaa aacattgcat tgaccaggag gagagaaata atacgacttt gcggctcact 874021 ttggaaaccc ggtttacatt taagagttgg agtacagtta agacgtttac tgtagtaggc 874081 gataatatca ttgctaccac aaatatgggc gaaaagctct acttgattaa ggatttctct 874141 tcatcatctg acgaatcgag aagggtgtat cccttggaaa tgtatcctga ttcaaaagtt 874201 caaaagataa taccattaaa tgaatgctgc tttgttgttg ccgcttactg tggaaatagg 874261 aacgatttag attcaagatt aattttttac tctttaccca ccatcaaagt tgggcttaat 874321 aacgaaacag gcagcctacc agatgaatat gggaatggga gagtcgacga catattcgag 874381 gttgactttc ctgaaggatt tcaatttggc actatggctt tgtatgatgt tttacatggt 874441 gagaggcacg taaatcgtta cagcgaaggc atacggtcgg agaatgacga agcagaggtt 874501 gccctaaggc agcgtagaaa tttactactc ttttggcgaa accactcttc tacaccaaaa 874561 ccttcactac gccgagccgc cactatagta tatgaggatc atgtatcatc ccgttatttt 874621 gaggatataa gttctatatt aggaagcact gcaatgagaa ctaaaagact atctccctat 874681 aatgcggtag cattggacaa gcctattcaa gatattagtt acgatcccgc agtacaaact 874741 ttatatgtgc taatggcaga tcaaacaatt cacaaattcg gcaaggacag gttgccttgc 874801 caggacgaat acgaaccaag atggaattct ggctatttgg tttcaagaag gtcaatagtt 874861 aaatctgacc tcatctgtga ggttgggtta tggaacctta gcgataactg caagaacaca 874921 gtataattcc ctcatttcca ataacattgt cgctgataaa atcgtgattc tcgatcaatg 874981 tgctacgcgt cgtgcagcgt gacaaggggc taaaaaaaga tacaagaatt cttgttgttt 875041 ccaatttgct tcgcctcaga aaaaaaaata aacagattat acaatttttg tttgatttgt 875101 attgggtact acatgtttta gtagttgata caaatacttc tttatcctaa tcgtatatat 875161 ttattttacc agcaggaatt cgtctttaat atcgtttcga ccatcgatca ttcctctgag 875221 tattgcaaaa acatttttgg aacaacccaa acttaaagtt acaaaactca aaaaaggaac 875281 aaaattaata aaacaaaaga atcgctgtta gaggtttatt gttgcactaa tagaaaatca 875341 tagaacttta aaaattatac tagaaagatg tcacaacaag ttggtaacag tatcagaaga 875401 aagctggtaa tcgttggtga tggtgcctgt ggtaagacat gtttattaat cgtcttttcc 875461 aagggccaat ttccagaagt ctacgtacca actgtctttg aaaactatgt agcagatgtt 875521 gaagttgatg ggcgtcgtgt agagctagcg ctatgggata ccgctggtca agaagattat 875581 gatagactaa gaccattgtc atacccagac tccaatgtcg tattaatttg tttctctatc 875641 gatcttccag attctttaga gaatgtacaa gaaaaatgga ttgccgaagt attacatttc 875701 tgtcaaggtg tgccaattat tcttgttggt tgtaaagtgg atttgagaaa cgacccacaa 875761 accattgaac aattaagaca agaaggtcaa caacccgtta catcacagga gggacaatct 875821 gtagcagacc agattggcgc aaccggatac tacgaatgtt cggccaagac tggttatggt 875881 gtcagagaag tgtttgaggc cgccactaga gcttcattga tgggtaaatc taaaacgaat 875941 ggtaaagcta agaagaacac tactgaaaag aagaagaaga agtgtgtctt gttataggag 876001 tgtctcgatc tctcagtcgt taacttagtg gcagatactg ccctttttca atcccattcc 876061 ttttctcatt gtatgtacgt atgccttttt ttgttatttt agctctaact atagctactt 876121 gtttttctcc cagtatgtgt ataatcttat tcttctctac atataagtgt attgctcagt 876181 aagtattatc atctattaaa gaagaataaa aattatcatg tatttattta caagtgcgta 876241 tcctatatat atatatatat atactttcgc gataaaattt tttaccaaat acccttctta 876301 acacctggca aattaccctt cagagcgttt tctctaaatt gatacctaca caacctaaaa 876361 tcacttagaa caaatcttgc atgtccagag tccacgcacc tatttttgat ctgcgtagat 876421 ctcatgtagt ttggcaatgc atttagtttt aactgagcct ccaacctcag ttttgttgga 876481 aggttcatat ttctagcgat gaatttcaaa gatttaacaa ggatttcatt ctctttaaat 876541 tgttgtcttt tgaagttatc cctaagtatg cgagcattga taaaccctgg tggtagcttg 876601 gtttttatag gaaatctgaa attacccatc ggttaatgta tatatttgtc agtttacctt 876661 ttctttcgtt tttcctttca atcctcttta tcgcagtttg gttcttagtt tgaatattcc 876721 tctgttttcg ctcttttctc gtacagcgcg aattctccgc cagctttaga aagttgtaat 876781 cattggtgtt attaaggaat aaataattag tcacatacat atggttatat atcgtactct 876841 atctatctag gcatcttgct ttaaaaattg cgcgaatcgg ctggcttcat gaattccaca 876901 ctcggtcttg gccttgccct tccatcttcc tgctctctca tcttcacctt ccttgacggg 876961 ttgtgtggaa tggtaatcac caatggatct atatccaagg tccaaaagtt cgttgtatgg 877021 tacattgttt gcatctatat actgtttaac ctgctcgaac gtccaattga tcaatggatt 877081 tatttttaag attccattaa gttcgtctat ttcaataatc gacagttggg agcgggcaga 877141 accttgtgat tttcttctac cagtaaacac agcacttata tgtagctctt tgtaggcacg 877201 atgtgcaggt tccactttgg ccagataatc gtacttgtca tcatctttct cccataagaa 877261 atccccgtat ttcgaggcaa aatctgcctc cgattcacat ccatccggct tatatacgtg 877321 aatggtttga tttttaggct ggtagtattt tttctcaatc tcgtttttta gtgttaaagt 877381 ttgtgggaaa tggtgcaaag tgtctataaa taatagttct ggcatgtagt atttttcaga 877441 tagctttgac aacatatcga tagtaaccaa gccagtcaaa ccaaatgcag tggtttggaa 877501 aaggtgagga aacgttacga tagaccatgc aataatctcc tgtggcgttt ccagcttgat 877561 tagttgttca ttccaatgat ccaactgttc ttgtgtgaca attatatcat tattcaaatg 877621 ataggtcttc attttatgag ttgctatggg ttgatacctt tgctggcctt agttttgatc 877681 ttaaagcatt gaaaaggtta caaacagtac agtatacttt ttttatatca atataatact 877741 atctctatga gcttttactt tgtcgagatt tgctgagtca tgttgtggct tttcttttac 877801 tagccacgtg aaatgatgat aaaaataaaa agaataacga cggaataaag aacagtatga 877861 taaaccgtaa agatatttag aatcaatagg tgatgtccac ccggtaacaa gatgccattc 877921 atgttaaact aggacaaatt tccttcttgt ccccccacca ttctctttta tccaattctt 877981 ttgtcagcgc gcattaaaga acaagaactt cgtactttta actactaact cctgtttgag 878041 aaagaggcaa atatatagaa aaataaaccg ataagatgaa tggaaacagc actaacaatg 878101 aacaattgca gcaagaactg gccactactc aagaccaagt ggcttcgatt attgagtcct 878161 tcgttgaatt aggtgtctcg atatatgatt ttcctggtac tccagaagcc accaagggaa 878221 tgatcaccaa cttgcaaaga aatgtggatc gcttgtacaa gctgaacgtg agaagcaacg 878281 atcctcaatc cagcttgtct aaggtggaca ttcccttgga agttgttcaa tacattgagg 878341 acggtagaaa tccagatatt tacacaagag agttcgtgga agccataaga agatccaacc 878401 aatatcaaag aggcaagatg catggattga agcaattaag agattcactt gctgacaaga 878461 ttgtggatga atttccagag ttgaaagaac ctgttgaaga tattataaag agaacatctc 878521 ccattgacaa tgtctccaat actcactaat agtaattttt ctgatttttt ttctcgctag 878581 aaaaaaaaaa tttcatggtt agaaaaattt taacatagaa atcatggcat catcgccaca 878641 attggaagag gaagcagctg ggaaattaga aacaatccac gcatcagcta tggcaaagag 878701 caaaaaaaaa acagatgttg tcgattcaac aaacctgccc attctagaat tactatcatt 878761 aaaagctccc attttccagt ctcttttaca tcctgaactg cccattataa taactggctt 878821 tggtacagga catattgtgt gccatcgtta tgaccccgct aagttgcaat cgcacctaga 878881 tcgtagacgt agaattgaca ctgcaactac aggcaaggat gcaaagaaag gtgtatgccc 878941 ttggattaga ttagatatag acctagaaac tggagatttg aaatttgttg atattgaaga 879001 acaacagcaa caaaagcaaa caggaaaaga tgaagacttg ggcgtaaaaa cactttggaa 879061 gactaaaaga cataaaggta gtgtccgtgc catgtgcttt gattctaaag gtgacaatat 879121 tttttctgtt ggatcggata atgttttaaa aaaggccaat actatgaccg gcaaagtcgt 879181 caaaaaggta aacttaagct cactgtttaa ttctgaagag aaaaaaaatg ataaatttac 879241 gaaattatgc gcctctcaaa ctcacccatt cattttaata ggcgatgaat ccggtaatat 879301 acacgtaata aactcggaaa acttggcatt atcaaattcc attcgttcga tacattttgg 879361 cgactctatc aacgatattt tccactttga taaaagatct gcatataaat tcatttcttt 879421 gggccagaca acgttagctt attttgacgt tcgcgacaaa gatgccaaac cgaacgtagc 879481 tggaaacgag gatggtaaaa ttttgatcag cgatgatcag gaggacgaag ttctttgtgg 879541 ttgtttcgtc gatcccgaag tagcagatac ccttttgtgt gggatgggcg agggtattgt 879601 taccgtctgg aaaccgaata agaatgattt ggaagatcaa atgagccgta ttaaaattag 879661 caaagatgaa agtatcgatt gcattgttcc tactttacaa gatgataact gtgtatggtg 879721 tggttgttcc aatggtaaca tttataaagt aaatgccaaa ttgggaaaag tcgtcgagat 879781 aagaaaccac agtgaattgg atgaagtcag ttttgttgat ctagattttg aataccgtgt 879841 tgtttctggt ggtttggaaa acatcaagat atgggaatta tcgagtgatg atgtagagga 879901 aaatgcatcg gtagagtccg atagcgacga acccctctcc cactctgatg aggatctaag 879961 tgatgacact agttctgatg atgaaacgac gcttgtcggg ctctcaaagg aagagctatt 880021 agacgaatta gataaggacc tcaaggaaga tcatcaagag gaaaaagaat ccaactcaaa 880081 atctgtcaaa aaaagaaaaa taatgaagga gaacaacaaa aaaaaggacc tgtatgagca 880141 tgggatcaag aagtttgatg atttatagat tatttctttt ttactaagaa aaacatatat 880201 catttatatt cagaaataaa taggattatt aacctagtgc tcccaaaaaa aataagttga 880261 actgtctctt tcgagaaaaa gaaagagaaa agaaatggtc tctagcggga tcgaaccgct 880321 gatccccgcg ttattagcac ggtgccttaa ccaactgggc caagagacca ttatattgtt 880381 aaagatgttg tatctcaaaa tgggatacgt cagtatgaca atacttcatc ctaaacgttc 880441 ataaaacaca tatgaaacaa ctttataaca aaacgaacaa catgaggtaa aacccggcct 880501 cccctagctg aacaactcaa acgtataaat gcctgaacaa ttagtttaga tccgagtttc 880561 cgcgcttcca ccatttagta tgattcatat tttatataat atataggata agtaacatcc 880621 cgtgaatcaa gctgataaac agttttgaca actggttact tccctaagac tgtttatatt 880681 aggattgtca agacactccg gtattactcg agcccgtaat acaacagtga gctattaaaa 880741 gagcttaagt attacagagt aatatcaatc atcaatcttg gatctaaagt aatcgtcgag 880801 acatttatac acttaagtga ttcctcttta caagcggagc ttactctata tattcattct 880861 tgtcagtttc ataacagttg tttcatacga tttccacatg tgtctcatat atattttatg 880921 tttaggttaa taactttggt aatgctaaat tatcttaatt tgacgtacac aaattcttcc 880981 tactgttata tatgttcgaa ttatctttta aattgttgct aaaaaagtta gagttatcac 881041 caaatcagtt gagcagatca ccattattct tatgtaaata cttgttaaaa gaagtagctt 881101 tcgcaaatac accaatgcat tcgttgataa tttacgcagt aacctcttac agaacgccta 881161 catacaactt aaactcgtaa tgttcaggct tataatgtca gtatgcattg ttacgcttag 881221 tatagttatt aaactacgga ccaaattata ctttaagcag tagttaaaga aagagattaa 881281 ataaagaatg atttacaatc tagtcgcaaa aacaagtaca gtgctgacgt cccatctttt 881341 aatgcctact cttttgatgt tcacttacat gttacaatga agccaaatca caaacattca 881401 aatatattcc atggcctctt agtttggcaa cccaagactc ggcataccat attggtaacg 881461 ctgtattgga gagatatatt ctaaaatatt gataattaat ggcaaaaagg cagtattaat 881521 gaaggttgaa tatggatctt aatataatcg tataagaggg gcataaaata tacgccgatt 881581 ggttcaacat taattatgat caatataaca atgcgtctgg taattaccat aacacttaat 881641 gtagcaactc gtataacaaa cgtatcatgc tcaattaata taaccttatc tctgcttcag 881701 cactgtctga gctactcttt taacgtttcc ttttgcaata ggtaccttca cactaaaaca 881761 tatacaatgg gtgcatttaa attgttacca tagcaactca tattacgatt cattaccact 881821 catttcaaca caacaacctc ttgctatcaa acttactttt gcttttattg cagatatctc 881881 gttatttctg caaaaacagc attcattggt aatgacaagg tcaattttgg cttttataca 881941 tttcacatgt acaggatagt ggaacacatt ccaaggaggt gaagaacgtc ccctttgata 882001 cttccataca aggacgatta aaaatacata agagaacaga tctgcaaaaa tgcgttttac 882061 ttcctttaca atctcaatgc cgataaataa gcgcaatgaa gattactcag caactgtatg 882121 ttggctcatg cgaaatatga atgtttcatt cgagattact tatcttgttt aacgcttgaa 882181 cagcgtactg taacttcttg ctacagaatg atggacccca ttataatact accgccttgc 882241 gaatgcgcaa tttattatga tcatgaaccc tgagaaatca aatgaatatt taaagtgtat 882301 gcaaaatgga caagaacatt atggtaacat tgtctacgac agaatttatt ttctgacttt 882361 aatagtgacg gttatacgaa attaatgatt cttcgagagg caactcactt tactgcaaat 882421 ggacctgcag agtttgcatc tagaggacaa tatgctgcac aaaaacgacc aatatttacc 882481 ttcaacgaaa acaaccttaa gaaacccctt caacaacaac gcagctatcg tatcgtagtg 882541 gtctccataa tgcgtgcacc tcctttagca cttatcgagt aataacatac gctagataag 882601 taaagtgtcc aggatattat aattatatga tatttcggga atggtttcta tatctagttt 882661 tttaacttag cctagacatt cgcctcgtat tataaaatac atgaaagtga cttgactgct 882721 tcatgagagt tatactaaga gcattcataa ctagaagaca cattttagtt tttattactg 882781 agtaagggtt tagtttgtac atacaaggca acatgaaatt caaggtgctg atgttcagta 882841 aagccgccta gctttacgtg ccgaaatatt gataatatgt ctcagccact tcctggctta 882901 actatttaaa tgatatttct gcatccatcg gtatggcgca caataaacgg tatctgagaa 882961 tatcgaaaag aacaccacaa tactactgag tgcaaacaca gaagagcgta ggtgattcaa 883021 ctaattgagt tagaaactgc atcaacgctg cataataaag atgctgctgt tcaggatcat 883081 tttttttaaa gactgaaaaa aattgcttat cgctttgcac gcgactcttt tttctattat 883141 ttgaaaaata gcttaaggga aaagaaaaga ataggtagct ttcaaagcaa gaacctctac 883201 gataaaggac aaagctagaa gcaaacaccg caaaaaaaat gagacccgtt gtatccactg 883261 gtaaggcatg gtgttgtacc gtcctatcgg catttggtgt agtaattctt tccgtcattg 883321 ctcatctctt caacacaaac catgaatcct ttgtaggatc aataaacgat cctgaagatg 883381 gacctgcgta tgttatattt tcttatttat ttcgccgtta cccatttacc atctcttata 883441 tctctcctcc ttactaacaa ttatatttta accctattgt ttatagtgtt gcacatactg 883501 tttatttggc tgccttggta tacctcgtgt ttttcgtatt ctgtgggttc caagtttacc 883561 tagccagaag aaaaccttcg atcgagttgc gttagtcttg aagccaatag gataatacca 883621 aatgcattaa tatcgtccaa ctgttctata tacttatcgt aacctcgttc catgtgacat 883681 tcttttttat tacacttttc gacaatagcg aattgagtga aatattatga aagaatatat 883741 agtataaata tatacattta tatatgaatt ctaatcaata aaagtcacag taaccagctt 883801 ttcctagctt ttcgaagttt cggaagtatg acaaaatatg agcgtgaccc tgaattggtg 883861 aactttctat cgaaagtgga ggatttgaac tctaagagat acagtaatat tcctagttca 883921 aaaccagcgg gggaagcgct ttcaccagtt agaagtcaca actctgggga atacagaagg 883981 gctgatatga tgacagggaa aaatgtggaa ggttgcgaca atttggccta ccgatctgcg 884041 tacaattatg aaatgacgtt ttctccaaag aagactcatt actcattaag tgagctgaat 884101 ctcgaacgaa taacgccaag gccggatttg gagggaagtg cctctcaaaa agaaaaaaaa 884161 tttttaattt ctgaagaaga ttatttatta ttgcagaaat tgaaagcctc tcaaacatat 884221 aatgattcca atgctgacaa aaatttgcct tcctttgaaa aaggtcctcg tatgcccagt 884281 cggggtcgac ccagaccgag agagaaggaa ataatcacca tccaatatga ttttgaatta 884341 ccaggaagag ccgatatacc ctcctcctcc tcttcttcat caccaccgcc tttgcccaca 884401 aggcgtgatc atatcaaaat cacagatggg aatgaagaga aaccgcttct tccaacaagg 884461 cctaacaaag cagaagttac agaaagtccg tcatcaaggt caataaaacc ggatgctgtg 884521 gtacctgagc gcgttaagcc tgctccacct gtctcacgct ctacaaaacc ggcgagcttt 884581 ttaagttctt tggaagataa caaattgaca aaggcgaaga gttataattc ggaaatggaa 884641 actcccaaaa caactgtaaa aagttctcat atcgattact tggattccat acaactaaaa 884701 ccaaccacct tatctcctac aatgaaaaat aaacctaaac caacccctcc ttctccacct 884761 gcgaaaagaa ttccaagatc tgaaagtttt atcaagtcta tgctaaactc gaatctcacg 884821 acaacttcca agccttcttt gcctgaaaaa cctcaaaagc tacggaatgc aaatttggcc 884881 gcccataaga ccaaaccaag cataccgcca aagaaagtgg agttgaatat agtattacct 884941 gagctacgtc ccgtagaaac ttctccaaca aagcagaact tcgaaaactc aatcgatttg 885001 cccaagttac gatccagcaa ccgtaacatt aaaaaagaag aggaggacag tattccagaa 885061 gcaataaaag gtatacaaaa tctgaagaaa accaaacagc agaagcctgc aatccctcag 885121 aaaaaatcat ttctaacaaa taattcgaaa aatactacac tcaaaaatgg tgatgatatt 885181 aacaagttaa atgacgaaat tgaagctcta tcattgcgga ataacctgaa gaaacggcca 885241 ccaacggcgc cacaacgtaa aatttctttg ccagaggcat tgcgaaaagt cgaattgatg 885301 aaaaaatcta aaaccgagcc tgttttagag tcctcaaacg aactgagcat aaacgcaaaa 885361 ttagacgcaa taattgcctc tagaaactta agagcatcta atactctacc agaacttagc 885421 ggtgttaaca ctaatattgc aacttctgac aagtatacta cttctagaga tgaaacagtg 885481 aaggaaacta aaccattagt tcacccgaat aaaaatagga ctcgtggtcc cagaagaaaa 885541 cttccaacac gcgtgtaact acagagtaga cctccgtatt ttacacatgt atgtacgtac 885601 atatgatgta acaataatat gataatttaa tgggatacat gtattatcgt cacttcccac 885661 gtttgcgctt tgacatttgc tccccttatg aacctgaagg aatataaatc atcgatcttt 885721 ttgctacact tttcctccct tattagaaaa tagcagtaaa attacaggct attcaaaccc 885781 tgaaacatct caattatggc ttggactagt acattaccag cgcatctact gaacctgatc 885841 aaaaactcca aatatgttca cgtggccacc tgttctaaag actgcatccc ttcagtggca 885901 ttgatgaact atatctatgt gccaggtgaa aaactgttcg gtcaaacaga taataagaat 885961 gactacatta tatttgtttc tcctcaggac acacaaaagt tttacaacat caaggagaac 886021 cctaaggtcg ccctgttgtt tcacgattgg atcatcgcga ataatttgtc agtgggcaag 886081 gaaagcatct ctgggactcc gacgccgact tctattcctc atgaagagca acgtcaaagc 886141 gagcttttaa atttgttaca ggagttaaat caagccgaat tgaaccaaat gagcgcatct 886201 attggtggcg aaaccgaaat tgtcaatcct gaaagtgaag aatccaagta ctataaagat 886261 ttaatactaa aggctaatcc tgatgcgaaa gcttttatat ttgaaaagaa caccgccgtt 886321 gttaaagtta gaattgataa tgctagggta tccaataatg agaacagaac aatgtttcta 886381 agtaaaggga agagttaact gtcctctgct tttctttatc tattttgcat acgattctgt 886441 atttaattat tctgtttttt tttttttttt attttttatt ttcatgtaca caagaaatct 886501 acattagcac gttaatcaat tgactagtta ccttcttgac caaaatctct agtgaactgt 886561 tcttgcttca gcaagtcatc ctcattcacg gtaggtctcg tcgatttgat agcctttaag 886621 aaatccttta tggtgagatc tggttctttt aattcatcag cttcaatatc cgtccaactc 886681 atctcgatgg cgccatcatc acctggagag catggtgtta gttttcttgt ttcgtcgtcc 886741 tccgtagaga catctttgaa atgtgtcgcg ctttgaattt ttcttatcgg ttgcattagc 886801 gcatctttca ccactacagc aatatcactc ccggaataac cttcagtcat tgcacctaaa 886861 gttctataat cttccttggt caatacgcat ggagtgtcgc cgacgttaat ctcgaacatg 886921 gtggttcttg ccgccaaatc tggtaatggt atatatattc ttctttcaaa tcttctcctg 886981 atggcactgt ccagttgcca tgggatattt gttgcgccaa ggaccaaaac accttgggag 887041 tcattcccaa caccattcat ttgtaccaat aattctgttt taattcttct acttgcttcg 887101 ctctctcctt ctcctctggt acctgttagc gcatccactt catctataaa aataatagaa 887161 ggtttatttt ctcttgccat cgcaaataac tgtttgacaa gtttttcaga ttcacccatc 887221 cacttagaaa ccaaatcact ggaactaaca ctgaaaaagg tagaattggc ctcggtggcc 887281 actgcttttg ccaaatatga tttacctgta cctggtggtc cgtacaataa gattcccgaa 887341 gtgggcttac ggttaccttt gaacaaatgt gggaacttga caggtaaaat aacggcttct 887401 ttaagggcct ctttggctcc ttccagtcca gccacgtctt cccacttaac attgggcttc 887461 tcagacaaaa tagcactcga taaggcacct cttagctttt tgttgtcttc tccaccatta 887521 tcctcaccct cttcctgaga gattttctta ttaccaccgt tggaaccact accagcgcta 887581 ggagatttct ttgccgcgtt tgcctcttca ctttccaagt gctttttcaa ctgctctgca 887641 cggtttagat actctgtaaa cttcgctctt atcaaatcct tcgacttagg gtttttctcg 887701 tatttcaaag ccaacatcaa ataatctaat ccgttatagt atgctgtata cgcctcctca 887761 tactgcgtgg ctgtgtccag gtcaatggcc ttttgaacca gttctattcc cttagttaaa 887821 aaatctcccg tgctcatttg taccccatct actataggca ctctatgctg ctttattttt 887881 gtcttccatg tcctcaaccc acgattaaat cgttcgatat catgaagttc ttattttttt 887941 ttttttttca cccagcgggg gtacccgtaa agcaatacaa taaatatcat caagcaagaa 888001 taaatagatg tacagaaaga acaaccatga cgtgttgtgt ttctattcag cgtgcggaac 888061 cgaatcctca gtcggagatt ctctgagaat gttcgtttga ggaagcttag gatacttggc 888121 gtagaagttg gggccctttg ggggctgtag ggaagaaact ggtcgttggc gcgactggag 888181 tggcgacatg tgaatcggac ttgaagtcac taacgggttt actgctctta ctggcgaagg 888241 tggtaaattt tctgtcggtt tgaggttgtc tcgctcaata tttttcatgt ctcgacgaga 888301 ctccaggtat ctttgatcga tgtttgcgtc gtccaacacc gactgcaaca gatgacactt 888361 ttccttgaca aattgtagtt ccttttgtgt agagtgcagc tgctgccgca attgcgcaaa 888421 ctttgcttgc cattgtagag gcacacaatc ctgagaattt ttagacaatg ggacaacgct 888481 ttcttcttcc tcatctgcgg gagaccccca tacaaacgct tggatcttgg caagagtctt 888541 agcaatattg aatccaaacg cgtgttgttg agccctcttt ttggagatat tcttgtagtt 888601 tttagaacgt gtcctttgtg aagcgtgtct aacatgattt ctttcgcgag gcacaaccac 888661 caatttgcgc tcttttcgta tccccaatgt cttttcctga attcccattg tgatcttcaa 888721 tgccaaccca accttctttt tactttgttg ggtctaaatt atgttacttt gtccatttca 888781 tctcttttca agatggaatc taaaagaaga aaaacgacaa aaggaacaaa agtgatgtga 888841 cgcgttattt ttcgcgtgac ataatagaaa aatatttcaa ctgggcatct ttaacacatg 888901 ttacaataaa gttgagatga cttgtttatg cctttaaagt ttgtaagtgg aactagaagc 888961 gtctatgtgt gaaatgtttg gctctgggaa tgttctgcct gttaaaattc agcctccgct 889021 gcttaggcca ctggcgtata gagttttatc aagaaaatat ggtttatcaa ttaaatctga 889081 tggactgtct gctcttgcag aattcgttgg cactaatata ggtgctaact ggagacaagg 889141 gcctgctaca ataaaatttc tcgagcaatt tgctgcagta tggaaacaac aagaaagagg 889201 ccttttcatc gaccagagcg gggttaaaga agttatacag gagatgaaag aacgtgagaa 889261 agtcgaatgg agtcatgaac accctattca acatgaggag aatatcttgg gacggacaga 889321 tgacgatgag aacaacagtg acgatgaaat gccgatcgct gctgattcat ccttacaaaa 889381 tgtttcatta tcttcaccca tgcgacagcc caccgaaaga gatgaatata aacagccttt 889441 caagccagaa agctccaagg cgttggactg gagggactac ttcaaagtta tcaatgcttc 889501 tcagcaacaa agattctcat acaatccgca caaaatgcaa tttattttcg tccccaataa 889561 aaagcagaat gggctaggag gcattgcggg ttttctacca gatatagagg acaaagttca 889621 aatgttcttg acaagatatt acctcacgaa cgacagagtc atgagaaatg aaaacttcca 889681 aaacagtgac atgtttaatc cattatcatc tatggtgtct ttacaaaatg aactgtccaa 889741 tactaaccga cagcagcaat ccagcagtat gagtatcacc ccaataaaaa acctactagg 889801 tagggatgct caaaactttc tactattggg gctcttaaat aagaacttta agggcaattg 889861 gtcactggaa gatccgtctg gatctgtcga aattgacatt tcccaaacta tccctacaca 889921 aggccattac tacgtgccag gttgcatggt tcttgtggaa ggaatatact attctgtagg 889981 aaataaattc catgttacct ccatgacttt accccctggt gagagaagag aaattacatt 890041 agaaacgata ggtaatctcg atctcttagg aatacatggc atttctaata acaatttcat 890101 tgctcgtttg gataaagatt tgaagattag attacacctt ttggagaaag aattaacaga 890161 tcataaattt gtaattctcg gcgcaaattt gttcctagat gatttgaaaa ttatgactgc 890221 actcagcaaa attttgcaaa aattaaatga tgacccaccg accctattaa tttggcaagg 890281 ttctttcact tcagttcccg ttttcgcatc aatgagtagc cggaatataa gtagttccac 890341 tcaatttaag aataatttcg atgccttggc gacgcttctg tcaagatttg acaatttgac 890401 cgaaaatacc acaatgatat ttattccagg tcctaacgat ttatgggggt cgatggtgtc 890461 attgggggca agtgggacat taccgcaaga tccaattcct agtgcgttta ccaaaaaaat 890521 caacaaggtc tgtaaaaacg ttgtatggag ctcaaatcca actagaatag catacttatc 890581 ccaagaaata gtcattttca gggacgattt atccggaaga ttcaaaagac accgtttgga 890641 attcccattc aacgagagcg aagatgttta tactgaaaac gataacatga tgtctaaaga 890701 caccgatatt gtaccaatcg atgaattagt taaagaacca gaccagttac cacaaaaggt 890761 tcaagaaaca agaaaactcg ttaaaacaat actagaccag ggtcatttat cgccatttct 890821 tgattccttg cgcccaattt catgggattt ggaccacact ttgacacttt gcccaatacc 890881 atcgacaatg gttctttgcg acactacttc tgcacaattt gatttgacat acaacggttg 890941 taaagtaatt aaccctggaa gtttcattca taatagacgt gctaggtata tggagtacgt 891001 tccatcctca aagaaaacta tacaagaaga gatatatatc taaataatgc atcaaaataa 891061 gaacacttaa acaagcacgg tagtgttggt actctgccat ctatttgtat ggatactttt 891121 tgaattttga tgtaacggat ttcggcatac aatatatggg atctatgggg actaaattgt 891181 cgtatcccat taaacttaaa ccagcaacac caaaaactgt atggaagaca tccacttcat 891241 tttcaggcct gtcgcttatt ccacccttct tctcatcttg acatttgagt ataaactcag 891301 ttagcttctc ataatttatc caatctagtc taccaataat agctaatgaa gataaaaccc 891361 accaactata gcaaacatcg ggcagtttac ttggcctacc gtttagtcca ccttctggta 891421 attgtcgttc gcaaagccac cacccaattt cttctagttg gtcgtcacta agcatatcca 891481 atttgttagc aattgccaaa gcgccaagac aggtaaaagc ttgagctgca tgggattcag 891541 cattaggaca taatccaaag ccaccatcaa aattataaca cttgagtaca aagtctacag 891601 cagggtcaac aacttcagac gttaattcac ccaaaattga tagtgcactc aaggctgtat 891661 aaacaaacct tgtatctacc tccccaaacc tgtcaccctg gaacgaacca tcttccaatt 891721 gattcccacg gatgaaggaa atcaagcgaa ccttacgatc ttttccaaga acatccaaag 891781 catcataagt ggccaagatc tgtacggcgg acaatgtagt taataaatgt gcatcatgtc 891841 ttggaaatgg tgcgaaagcg ccgtatttgt cgtcccaaca gctcagaaca aatgatataa 891901 cctcttcttt cacaaatgtc tctggagaat caagcacaca caaggcagta agtccccaat 891961 atatcccatt caaacgaaga tgctcggtaa gccagtattc aaaattatgc ttctttgtat 892021 ccaatgattc aatataacgt atatgctttt ccttaagtag cgtaagagat cctgacatgt 892081 tcacaatttt ctagtggaga aaacagaatc attagtaaca gtagtggtat ctgaaatata 892141 tatatacaca gtttcttaaa ttgttgtctt tactactggt attactatcg ctattacaag 892201 cgaagtcatt aagtacggaa atgtttaaac gtagagagct agtaaaggaa aggctgttac 892261 atgatcacta atcgtaactt tgcaacgagc ctgagggaaa tgactagtac tattaccttg 892321 ttgaacggaa tatgagtaaa tatattgcac ttgaaaatct tccggtagat ttgcaacata 892381 aaggagctac acaaaatgaa agcaccgctg atatactgaa acagttgcca catgaacgat 892441 tacaagctgt cctggagaag ataccagaag aagatcttga ggtgagacga ttgctttcaa 892501 ttttaaagaa gccggaagta gtggagaatg aagatgtaca acaaagaaga atacggttgg 892561 ctgaaatttt aatggttgat gaaattgatc ttgagaacat taataacatg gaaaacataa 892621 atggggaaga agtagacgaa gaggacgatg aggacttctt cactccagca acatctgagc 892681 tcatttttgc gagaagattt ttgataaatt attcacttga aagatctcga aagaggctac 892741 agaaagagat ggaaagacat caaaagttca atacaagaca ggaattactc agtcggcgta 892801 cagaattaca gcgtatggct aatttagagc ttgctggctc tcaattagta tctacgaagc 892861 ctatttccgc agtttcttta tctaccgatg acatggttgt cgcaacggga agctgggcag 892921 gtgatcttca ggtattaaat tctcaaacac tgcagccatt gacacaaaaa ctcgactctc 892981 atgtagggaa aatcggagct atagattggc atcctgattc aaacaatcaa atgatttcat 893041 gcgcagaaga cgggctcatc aaaaactttc aatactcaaa cgaagagggc ggccttcgat 893101 tattgggaga tcttgtggga catgaaagac gtatttctga tgtgaaatac caccctagtg 893161 gcaaatttat aggtagtgcc tctcatgata tgacttggag actttgggat gcgtcaacac 893221 atcaagaact gctgctacaa gaaggccatg ataagggagt gtttagtctg tcttttcaat 893281 gcgatggatc tcttgtttgt agcggtggca tggactcgct ttcaatgcta tgggatataa 893341 gatccggaag taaggtgatg acactcgcag gacactcaaa gcctatttac accgtagctt 893401 ggtcaccaaa cgggtatcaa gtagccactg gtggtggtga tggaatcatt aatgtttggg 893461 acatcagaaa acgggatgaa ggccaactaa atcaaatatt ggcgcatcgt aacatcgtta 893521 cgcaggtaag gttttcaaag gaagacggcg gaaagaaact tgtctcttgt ggctatgata 893581 atttgatcaa tgtgtatagt agtgatacgt ggttaaaaat gggaagttta gcaggccaca 893641 ctgataaaat tattagcttg gatatttcga ataattctca ttttttagtg agcggcggat 893701 gggataggtc tatcaagctc tggaattgat tgtgtaaaga aatgtattta gtatttttga 893761 aactaacgtt ttattaacac tgcattattt atttaattat acatttcctg gtttttttgc 893821 cctggatttt ttttttgtgt taccattttg agtacgaact cgtggaattg ttaagttttc 893881 caagttgtcc atcgtcttcg ataactgtcc cactaactcc tcgtttagat cattctcaag 893941 ctttaattcc tttttcaaaa agccaatttt ctcattcaat tcttttgtag agatttcaga 894001 cttttcgaat ttcaatttca actcactttc taatccattt tgtttctcat taagtttgtg 894061 tgtctcctcc tcattttccc ttatagcatc aacggctctt ttgatttctt gttccatata 894121 tttcttctca gtatcccttg atacacttac cctttcttct ttctcgatct cgtcttgtac 894181 attgtctgtt ttaacgaaag cgtcttttaa ctttgataat gtttcacctt gggccatcaa 894241 acttcccttt aaagtttcaa tgtctttttc cagtgtttcg atttgggaaa acttcaaatt 894301 gttttcaact tctagttcat gcgacctatt taagttttca ttattggttc gcaatacggt 894361 ttcatattct tttataattt tctcatcttc atttgagaaa aatttcagat gatcattttg 894421 caaatcatca aggcaagaat aatcatccag ctcctgtttc tgaacgcaaa tatccatata 894481 cacttctccc attgattgaa tcagtttgtg tgttatgatt ccacttgata agtggtaatt 894541 tacattcgag gagttgtcag ctgtagtaat acctgttagt tgtgtcatgt cttgttttaa 894601 aggatttgta taataatcgt tctttaatct tttggtagag taaaaacttg gagtaatatt 894661 atcctcaatt ccggcaacag ttgaagatgc tgccttatta gcaccatggc gtcctctttt 894721 tttggaacag ttggaaaaag catcctctag ttgatcatct gactttttga aatgtacttc 894781 cgttaacaaa gacctttcta catccatgga agtatattgt tttaaagggt aaatatctgg 894841 taatggccac ggtactgttg ggttttccaa ccattctact aaataatgca gcttttgtga 894901 ataaatgggc ctcaaatcag gtggaagtgt gcccagtcga tctcttaaaa ttaccatagc 894961 tgcggtaacg ttctccaagt attctctact gttcttgtca aattttttac caaagaataa 895021 cctacaatga tcaattgaat taatggccac tagcctaaca attggagcat atctttctaa 895081 acccttcctc tccctcttat attgcaacaa atattgaata tctttttgac ttgtatccac 895141 tgtagtatct aagcagatca gcatgtcgaa tcgagccttg gattttatcg gatattttgt 895201 gaaattaatt ccttcagaag aaaacaaatg aactgtacac gagaagtcat ttgccttttg 895261 ttttgacttg atagaatgac cgtcatatct tttgatatgc accttatttc ccaatagtaa 895321 ggcttccagt aagtccattg ttctcccagg tctacaaaca atggccgttt cagtttcata 895381 ttcttgaaca agatttatga gatctctcaa aacgctgaac tttccactat tttccgctaa 895441 atgtgcagga acatcacgag ttattaacga tttaggcata taatgatcta ttagtaggta 895501 tggatgggtt gctaccagtg aaccatttaa acacatggtc ttcatagatt cgagaatgac 895561 gtcctctttg tagtgtgacg tttcgaagta tctcaagata tctgagtagt gtaatgatac 895621 tatttgatcc gtgagttctt tttgataaag cgacattgta gttggcagcc aataatcacc 895681 ggaagtattt cctgagattc ccagagtagt agcatcaaca attgtaggta ttggtttcgt 895741 gtctaaaatg cgtagtaaat ccatactaaa gggcaattag tttgtgcttc taactttcct 895801 ttttatcatt tttatagtct aaagtatttc ttctctctat tgtctttaat tgaaactttg 895861 gaaaaccgcg gtgttatgga tactagaaca ctaatgttat tttttgcagt tatcaattaa 895921 agtaaaagaa gaacaaactg agtggattaa atcagtaact atggatatga aagtagaaaa 895981 attaagtgaa gatgaaattg cactgtatga tagacagatt cgtctatggg gaatgacagc 896041 acaggccaat atgagatcag caaaagtatt gctgatcaat cttggagcaa ttggttctga 896101 aattaccaaa agtatcgtcc ttagtggtat agggcattta accatattgg atggacacat 896161 ggtgactgaa gaagatttag gatcccagtt cttcataggc tctgaagatg ttggccaatg 896221 gaagattgat gcaacaaaag agagaattca agacttgaac ccccgtatag agttgaactt 896281 tgataagcag gatttgcaag aaaaggacga agagttcttt cagcagtttg atttagtcgt 896341 ggctacagaa atgcagattg atgaagcaat caaaattaac acattaactc gaaaactaaa 896401 cattccatta tatgttgctg gttctaatgg attgttcgct tatgttttta ttgatttgat 896461 tgaattcatt tcagaggatg aaaaattgca aagtgtaaga cctaccaccg ttggtcccat 896521 ttcaagcaat aggagcatta tagaagttac tactagaaaa gatgaagaag atgaaaaaaa 896581 aacatatgaa cgaatcaaga ccaagaactg ctataggcca ctgaacgaag ttttaagcac 896641 agcaacatta aaggaaaaaa tgacgcaaag acagttaaaa agagtcacta gtatcttgcc 896701 gttaaccctg tccttattgc aatatggtct caaccaaaag ggcaaggcca taagctttga 896761 acaaatgaaa agagatgcgg ccgtatggtg tgaaaatctg ggtgtaccag caacagtggt 896821 aaaggacgat tacatacaac agtttatcaa acagaaaggt atcgagtttg ctcctgtcgc 896881 ggccattata gggggtgctg tagcgcagga tgtcattaac attctaggta aaaggctatc 896941 tccattaaat aatttcattg tttttgatgg tattacatta gacatgccac tttttgagtt 897001 ttagatatat acatacctac tatactgtag tttcagccaa aaaaaataat aaaaaaagca 897061 taattggagg cagtaaagca ttatagtcat acacaataat aataataata ataataataa 897121 taataataat aatagtagta gtagtaatgg taataaaaaa gttagaaaag aaattagata 897181 cagatattcg tagtaaaggc cacgcagtac aaaaaagacg gagaatatat tatataaaat 897241 cctctactct tttcgttcag gtccaaagga aaattcttgc acgcgcaatg gactgaacag 897301 gccttatatt atacaaaaag cctaataacg atcaaataaa acaaaagaaa gccgttgctc 897361 ctatgcctga ccagagacgg ctacttgttg taagtgagtc atgaaatttt gtaaggaaac 897421 atcatctgtt aagacaattg tagatcctcc gcgcgccatg tcttgatagt tatcggaagg 897481 attcaattta gataacaaga atctggcttg agaaccaccg gcttcagtat caatgaatct 897541 tggtagcggg aacctatcta ctaacaattc tgcggcttct aattttggct cttcaagaag 897601 agctttgaaa tctgcgtact gtggatcgtc ttggtaaccg gcttttctcc attgagcgat 897661 ttgctcaccg tggtatatta agatgaagaa aaatgtatct aataatagaa tggtattggg 897721 tttgacggag atagagtcta ataataccgg ttgtggatcg tcctccattg agaaagaagt 897781 tagagttggt tgaatcatga ttaaagaatt agtcgtatcc tctcttgtga aaatatgtct 897841 ataaaatgca gtttcatccg gagaattgtt aaagacactt aagaattggg atcttcttaa 897901 ataataggta aattgaggat acagtgagaa atttggagcc aacctgaaag attgaggatc 897961 atctttatta tagtcggcgt acttttgaca tagcttaatc aaagttctgt ctaaccatct 898021 aataacatct gcaccatcat cggtttcagc cttgtgaaca gcaatacgag ccatcaaaac 898081 ggcagcagct tcttgatcga aagaagctgc aatggcagga gtaccgaagg gcaaaagctg 898141 gtttgcgacc gtggtgactc tgatacggtt ggtaccagag gagtgttgat aagtagtgat 898201 gaattgagta tatgctagat gaggtctatc tgctgaacca ggggcagaca tcattgggtt 898261 agaattagcc gcagtgtttg caatttcaaa gaaaatcgca tacgagtgat aaggcgataa 898321 ggaagccatc ttccaggtgg acgttgcacc tataccgatt tcagattcac tgatgttgtt 898381 agcgtctgtc ttctttacag cagaagcatg cccaatcaaa ccttgtacct tcaagtcttt 898441 acttgtcttg actgccatat taccattgaa agccatcttc aaataccctt cttcatcctt 898501 ggcaaacaat ctcaagtatg attgcttaaa aatcgcggta gagaaggcat cggttagcaa 898561 caacacacct ccagtagagt cggtcaactg tttcatttca gacataccga tttgatcgta 898621 acaaccggca aaaatatcaa cagtgtgtcc attggcggca actctttgtg caatctggtt 898681 gtaaaactta caggccttct tgtaatgttg cgcgtgatca gaatcgatgt cgtggtggga 898741 tcttaaggga tcttttaact ctgagttaac aatcaaacct ggggccacgg tgcctggacc 898801 ggaggcgaaa agaatgattc ttgctgggat gttcttatag cagccctgta aaagcaaaga 898861 tgcaatgttc aaagcggaac ctgtggccct taatggccta tgacccgctg gaacagacca 898921 ttggtctgga gacagatttt ccagtaattg attcagtttg aactcgacct gttccaaggg 898981 caggaagaac ctattcaaag agaagggcgt aactttgttc atggcgttcg gtagatgaga 899041 tgcagcaccg ccggggccgg taggcttttg gccggtcaac atttccgtca acgcttcgag 899101 ctggtactcc ctgtctcctc tgaacacgtt gcacctgtca atagtttcgc tggacagatc 899161 gtgcaattga acaacgtttc cgtaagtgat caacccaatc agcgcgttgg gaggtaatag 899221 agacaaagaa gtgatgatag actcctttag cgaatcgagg ttctcggttt ccgaagtcaa 899281 atccacaaca aagaagaaaa tgggaggaac ggtaacgggc ttattggtga tgtactcaat 899341 ggtggtggac tgtaactcta gcggcatatt ctcctgtgac aagttggtgt actgtggagg 899401 taaatggttc ctggagttac agatgggaca actccaggac gaattgcgcg gatcaatcac 899461 acagtaagga tttagaatcg acttacagtg tggaccggaa cacacaactg gattgtatgg 899521 ggcaacgttc aattcgtcat actccttcaa aggtgtgtac aaacagccca cagggacgac 899581 gttgctgtta gcgtcgcttc tagtagaggg aaacacgttc caggtgaaac ggaccccgtt 899641 gatgtcttca ttagtctcga agtccatggc tagaaaagag gaaggggagg caggcgacag 899701 acagataaac actggcttca gttaattgtg tgtcttgctg aacgtggaaa gatcacaaca 899761 agtatctttt tttctttttt caaacgtgtt tttcttttat tcttgctaga actttcctcc 899821 tttgtaacaa acgagaggcg gcgggctagt cgtcgcaagc gacaaatctc aactgacagt 899881 aaataacggt gataaaacaa aattagcgca atctctcaaa ctactgagga caaccaactt 899941 gaattgcact cttccaagtt gtagcatggc ttggggggtg tgtgatccca tcctgtatta 900001 tggcaaagca ggcaaaacaa ccgctctgcc gtccgggtaa cttttcttgt tccacctctt 900061 ttccccaaca tatatgaaca tgagatggta agagcaagaa acaacggttc tatgagcaac 900121 gcaaaaacag cacagcacac acagcaccgc gtactatacc acaccacaca ctacgtcaca 900181 acacaacaag acaatgagcg agagcagtga tatcagcgcg atgcagccgg tgaacccgaa 900241 gccgttcctc aaaggcctgg tcaaccatcg tgtaggcgtc aagcttaagt tcaacagcac 900301 cgaatataga ggtacgctcg tgtccacgga caactacttt aacctgcagc tgaacgaagc 900361 agaagagttt gttgcgggtg tctcgcacgg caccctgggc gagatattca tccgctgcaa 900421 taacgtgctg tacatcaggg agctgccgaa ctaagacgac tgtgctcatc tcccttacat 900481 accagtatat ttacatacgc cctctactgt aatacaatat cattctatag cactcgcatc 900541 gcgtattttt tttttatttt cttgctttat attgttctat ttttcttcct tattcctgcc 900601 tctggatttc cctcgcatga caaatagcgt ggaaaaataa aggatttcca gtatttgaaa 900661 aattttcagt attcttacgt gttcctaact catatagacc gctattgtaa taacgctatc 900721 gcttcaatta cacacaaaca tacacgcacc cacaatgagc atcgaatact ctgttatcgt 900781 tcccgcttac catgaaaagc tgaacatcaa acccttaaca accagattgt ttgccggcat 900841 gagccctgaa atggccaaga agaccgagtt gatctttgtc gatgacaact cacaggatgg 900901 ctccgttgag gaggtggacg ccctagctca ccaaggctac aacgtccgca tcatcgtcag 900961 gacaaatgaa cgtggtctat cctccgccgt gcttaagggt ttctacgagg ccaagggtca 901021 gtacctggta tgcatggacg cagacctaca acaccctcca gagaccgtgc ccaagttgtt 901081 cgagtctttg cacgatcacg cctttactct gggcaccaga tatgccccag gtgtcggcat 901141 tgacaaggac tggcctatgt acagacgcgt catttcctcc actgctagaa tgatggccag 901201 acctttgacc atcgcctccg accccatgag cgggttcttc ggtctacaaa agaagtacct 901261 cgaaaactgc aaccctaggg acatcaactc gcaaggtttc aagattgccc tcgagcttct 901321 cgccaagctt cctcttccaa gagaccctag agtggcgatc ggcgaagtgc cattcacttt 901381 cggcgtgaga acggaaggtg aatccaaact gtcaggtaaa gtcattatcc aatacttgca 901441 acaacttaag gagctctacg tcttcaagtt tggcgccaat aaccttatcc ttttcattac 901501 tttctggtcc attctgttct tctacgtttg ctaccagcta taccatttgg tcttttaaag 901561 gaagtgaatg gtaacgaaaa aaaaaaatct ttctttatat gtctctttaa gtactccctt 901621 tcagttatat gccttttatt gtctgtccct attctaatcc tctactcggg ccatcattgt 901681 taacgtaata tttgccctag ggtaaaaaca ttaggttgat taggccataa ctcattctgc 901741 cccaccccca cacatagggt tcaggaactt ggttttcaac cctactgcat tgtttcccac 901801 gcggcgctac caaaatatat ccaattttct tttttgtcac aacagcagca accccttgaa 901861 atggccaatt cttctcgaga ctttgctccc ttaatctttt cttccccccc ggtttcttga 901921 tgattatata tactaacctc gtatattaca cactgtactt gaagtcactc atatccgaat 901981 actacttctc ttaacttcca gtcaacccga cacccacaat cgtccttagt atataactgc 902041 tttatgaata gatcattact gctacgtttg tcggataccg gtgaacccat tacaagctgc 902101 tcttacggaa aaggtgtctt gacgctacca ccaattccgc tccctaagga cgccccaaag 902161 gaccaaccgc tctatacggt caagctactg gtatctgcag gttcccctgt cgctagggat 902221 gggctagttt ggactaattg cccaccagat cacaacacgc ccttcaagag ggacaaattt 902281 tacaaaaaaa tcattcattc cagctttcac gaggatgact gcattgacct gaatgtctac 902341 gctccaggct cgtactgctt ttatctatct ttcaggaacg ataacgaaaa acttgagaca 902401 acaaggaaat actactttgt tgccttgccc atgctttata taaacgatca gttcctacct 902461 ttgaattcca tcgctttaca aagtgttgta tcgaaatggc tgggctctga ctgggagccc 902521 atcctatcga aaattgccgc taaaaactac aatatggtac atttcacccc tctacaggaa 902581 agaggcgagt ctaactcgcc ttactctata tacgaccaat tgcagttcga ccaggaacac 902641 tttaagtctc ctgaagacgt gaaaaattta gttgagcata tacatcgcga tttaaacatg 902701 ctttcattaa cagatattgt ttttaaccac acagctaata attctccttg gttagttgag 902761 cacccggagg ctgggtataa ccacatcact gcgccacatc taatcagcgc catagagctc 902821 gaccaagaat tgctcaattt tagtaggaat ttgaaatcct ggggctatcc taccgaactg 902881 aaaaatatag aagatctctt caagatcatg gacggtatta aagtgcatgt tttagggtcg 902941 ttgaaactgt gggaatatta tgcggtaaac gtgcaaacag ctcttcggga tatcaaagcc 903001 cattggaatg acgaatctaa cgaaagttac agttttcccg agaatattaa agacatctcg 903061 tccgatttcg taaaactagc ttcctttgtg aaggacaacg tcactgagcc taacttcggc 903121 actcttggtg aaagaaactc aaacaggatt aacgtgccaa aatttattca actactgaag 903181 ctcattaacg atggtggtag tgatgacagt gaatcttcgt tggccacggc tcaaaacatc 903241 ttgaacgagg tcaacttacc cttatataga gaatacgacg atgatgtcag tgagatactc 903301 gagcaactgt tcaatcgtat caaatatttg agattagatg acggtgggcc caagcaaggt 903361 ccagtgaccg ttgacgtgcc cttaacagag ccttatttta cgaggttcaa aggaaaagat 903421 ggtactgatt atgccctcgc caacaatggc tggatatgga atggtaaccc actagtggat 903481 tttgcatcgc agaattcaag agcttattta cgtagagaag ttatcgtgtg gggggactgt 903541 gtcaagttaa gatacggtaa aagccctgaa gactctccgt atctgtggga aagaatgtcc 903601 aagtatatag aaatgaacgc caagatattt gacgggttca gaattgacaa ctgccattct 903661 actccaatac atgttggcga atatttccta gatttggcaa gaaaatacaa cccgaaccta 903721 tatgtcgttg cagagctgtt ttctggttcc gaaacactag attgtctgtt tgttgaacgg 903781 ttgggtatct cctctttaat cagagaggca atgcaagcct ggtccgaaga agagttgtct 903841 agattagtcc ataagcatgg cgggaggccc attggctcct ataagtttgt tcctatggat 903901 gacttctcat atcctgcgga tattaattta aacgaggagc attgtttcaa cgactccaac 903961 gataactcca taagatgtgt atcagagatc atgattccaa agattttaac cgccactccg 904021 ccacacgctt tattcatgga ctgtacccat gataatgaaa ctccctttga aaaaagaaca 904081 gtggaggata ctttgcccaa tgctgcattg gtggctcttt gctcgtccgc cattggatct 904141 gtttatggct acgacgaaat ttttccacat ttactgaatt tggtcactga aaaaagacat 904201 tatgacattt ctacgcctac tggtagcccc tcgataggaa taaccaaagt caaggccact 904261 ttgaattcga ttagaacgag tataggagaa aaggcgtatg acattgaaga ctcagaaatg 904321 catgtgcatc accagggcca gtacattact tttcatcgta tggatgttaa atccggaaaa 904381 ggttggtact tgatagcaag gatgaaattt tctgacaatg atgaccctaa cgagacttta 904441 ccaccagtgg tgttaaacca atccacctgt tctctcaggt tttcgtatgc tttggaaaga 904501 gttggcgatg aaattcccaa cgacgataaa ttcattaaag gtattcccac gaaattaaag 904561 gagcttgaag ggtttgacat ttcttatgat gattctaaga agatttcaac gataaaactg 904621 cccaatgaat tccctcaagg atctattgcc atttttgaga cccaacagaa tggtgtggac 904681 gaatccttag atcattttat aaggtcaggt gctttaaagg ccacttcaag tttgactcta 904741 gagtcaataa attccgtctt gtatcgtagt gagccggaag aatacgatgt tagcgccggc 904801 gaaggtggtg cttatattat tcctaatttt ggaaagcctg tgtattgtgg tctgcaaggt 904861 tgggtttccg tattaagaaa aattgtgttt tacaatgatt tagcacatcc cctcagtgca 904921 aatttaagaa atggacattg ggctttagac tacactatca gtagacttaa ttactatagc 904981 gatgaagcag gaatcaatga agtgcagaac tggctgcgtt caaggtttga tagagtgaaa 905041 aagttaccga gctacttagt gcccagttat ttcgccttaa ttatcggcat cctctatggt 905101 tgttgtcgct taaaagcaat acagctaatg tcccgtaata ttggtaaatc tacattgttt 905161 gtacaaagct tatctatgac atcaatccag atggtttcca gaatgaagtc aacctctatt 905221 ttaccaggcg aaaatgttcc atctatggct gcagggttgc cacactttag cgtaaactac 905281 atgagatgtt gggggagaga tgtattcata tcgctaagag gtatgctatt aacaacaggt 905341 agatttgatg aagctaaagc tcatatacta gcctttgcaa agactttgaa gcatggttta 905401 attccaaact tgctggatgc cggtagaaac ccgagatata atgctcgtga tgctgcctgg 905461 ttcttcttgc aagctgtaca ggattatgtt tatattgttc ctgatggcga aaaaatatta 905521 caagagcaag taacaaggag attcccactg gatgatactt acattcctgt agatgatcca 905581 agggcattta gttactctag taccttggag gagatcattt atgaaatttt gagtaggcat 905641 gccaagggaa ttaaattcag agaggctaat gcaggtccaa atttagatcg tgttatgact 905701 gataaagggt ttaatgttga aattcatgtc gattggtcga ctggcttaat tcatggtgga 905761 tctcagtata actgtggtac ttggatggat aagatgggtg aaagtgaaaa agcagggtct 905821 gttggtattc ctggaacacc cagagatgga gccgcaatag aaatcaatgg gcttttaaaa 905881 agtgctttaa ggtttgttat tgaactaaaa aacaagggat tgtttaagtt ttccgatgtg 905941 gagacgcagg acggcgggag gatcgatttc actgaatgga atcaattact tcaagacaat 906001 ttcgaaaaaa gatattatgt tccggaggat ccatcacagg atgcagatta tgacgtgagc 906061 gctaaattgg gtgttaatag acgggggata tacagagatt tgtacaaatc aggaaagcct 906121 tatgaagatt atcagttaag accaaatttt gctattgcca tgactgtggc accagagtta 906181 tttgtgcctg agcatgccat aaaagcaatc accattgcag atgaagtctt aagaggtcca 906241 gtaggtatgc gtactttaga cccaagcgat tacaattacc gtccgtacta caacaacgga 906301 gaagattcgg atgattttgc cacctcaaag ggtagaaact atcaccaagg ccctgagtgg 906361 gtctggcttt acggctactt tttaagagcg ttccatcatt tccactttaa aaccagtcca 906421 cgttgtcaga atgctgccaa agagaaacca tcctcttatt tgtatcaaca attatactac 906481 agattaaaag gccatagaaa atggattttt gaaagtgtgt gggcaggatt gacagagcta 906541 accaataaag atggtgaagt atgcaatgac tcaagcccca cgcaagcctg gagttctgct 906601 tgtttgttag atctatttta tgatttatgg gatgcctacg aagatgattc ctgaaaatag 906661 ctaaagcata aattaattga acggtccctt tttgccaccc gctaatactt ttatttctgt 906721 tcaactatat atacatatat atatatttac atatttttac ctccctatct ctattgataa 906781 taaaacaaat aaaaatcgta tatttttgta tatgtattat cgttttgagg agcgagagcg 906841 aaaacgaaaa taaaagaaat aaagggaaca cacgtgaaag tgaaggacag caccaaccaa 906901 gggggacaaa acgcgtcaga gcaagaggtg aaagggttgc cacgtacgta tttgaaccgg 906961 agtgagccgt ttgcgtgtta caatcaattc gatatctttg ttgttttgtt taattcgcta 907021 agatctaagt ttttaactaa gtgagcagcg gcagttacag aaagaggcga gaagtagaaa 907081 caagggtgta tagattttcg ttacctcaca tagatataga acgaattcat aggtaccaaa 907141 tacattccac ttacaccttc caggctcaag tcttgaaaag aaagcagaac atacagcccg 907201 gttgaatagc atgagtcatg gttgccgaag aggacatcga gaagcaagtc cttcaattga 907261 tagacagctt ttttctgaag actacactac taatatgctc caccgaatca agtcgatacc 907321 agtcttctac agaaaatata ttcctatttg acgacacatg gtttgaagat cactcagaat 907381 tagtgagtga gctacccgag ataatatcaa aatggtctca ctacgatggt cgaaaagagt 907441 tgccaccctt agtggtagag acatatttgg atttaagaca gttaaactcg tctcatttag 907501 ttagattaaa ggaccacgaa ggccatttgt ggaacgtttg caaaggaact aagaagcagg 907561 aaatcgtgat ggaacgttgg cttatcgaat tagataattc atccccaact ttcaaatcat 907621 acagtgaaga tgagactgat gttaatgaac tttctaaaca gctagtcctt ctcttccgtt 907681 atttgttgac tttaatacag ttactaccca caacagaatt ataccaatta ttaataaagt 907741 cttataacgg cccgcaaaat gaaggaagtt ccaatccaat aacttccacg ggcccactag 907801 taagtatccg gacgtgtgtc cttgacggat ctaaaccaat tttatcgaag gggagaatag 907861 ggttgagcaa accgattatt aatacatatt ccaatgcgct taacgaatca aacctgccag 907921 cccatttaga tcaaaagaag atcacacctg tatggacaaa gtttggactc ttaagagtct 907981 cggtatcata cagacgtgat tggaagtttg aaattaacaa tacaaacgac gaattatttt 908041 cagctcgaca tgcatctgtc tcacataact cacaaggacc ccagaatcag ccagaacaag 908101 aaggacaaag tgatcaagac atagggaaac gccaaccaca atttcaacag cagcagcagc 908161 cccaacagca gcagcagcag cagcaacagc aacagagaca acaccaggtc cagacacaac 908221 aacaaagaca gatacctgat aggagatctc tttcactttc tccttgtaca agagccaatt 908281 cttttgaacc acaatcttgg cagaagaaag tctatccaat atcgagacct gttcaaccat 908341 ttaaagttgg ttcaattgga agtcaaagtg cgagcagaaa tccctctaat tcatcgtttt 908401 tcaaccaacc acctgttcat aggccaagta tgagctccaa ctacgggcca caaatgaata 908461 ttgaaggtac cagtgttgga agcacctcaa agtattcctc ctcctttggg aacattcgtc 908521 gtcactcaag tgtaaagacg acagagaatg ctgaaaaagt atcaaaagct gtaaagagcc 908581 cactacaacc tcaagaatca caagaagatt taatggattt tgttaaatta ctcgaagaaa 908641 aacccgatct aactataaag aagacaagtg gaaataatcc acccaatatc aatatttctg 908701 attctctaat cagatatcag aatttgaagc caagtaatga cttattaagt gaagatttat 908761 ccgtaagttt atccatggat ccaaatcata catatcacag aggcagatca gattcccact 908821 caccattgcc ttcaatatcc ccttcgatgc attatggatc gttgaactcg agaatgtctc 908881 aaggcgccaa tgcaagccat ttgattgcaa gaggcggtgg gaattcatct actagtgcct 908941 tgaatagtag aaggaattct ttagataaga gctcaaacaa gcagggtatg tcaggcttac 909001 ctcctatttt tggtggagag agtacttcat atcaccacga caacaaaata caaaagtaca 909061 accaattagg agtagaagaa gatgatgatg acgagaatga ccgtttgctc aaccaaatgg 909121 gaaacagtgc tacaaaattc aaaagttcaa tatctccaag atcaattgat agcatttcaa 909181 gttctttcat aaaaagtagg atacctatca gacaaccata ccattactct caaccaacta 909241 ctgcgccctt tcaagctcag gcgaaatttc ataaacctgc aaataagtta atcgataatg 909301 gtaataggag taatagtaac aataacaatc ataatgggaa tgatgcagtt ggtgtgatgc 909361 ataatgacga ggatgatcaa gatgatgatc tagtattttt catgagtgat atgaaccttt 909421 ctaaagaagg ttaaaaatgg taaagtttta ttttaaaggg cacaactaaa gaaaaataat 909481 caaaaaaaag gtgaaataga tatgcaagaa aagaaaaaaa aatacaatac tagtaaactg 909541 aaataaaaaa gattagccat aatggatttg tttctctttg ttatcgatat tcttacctct 909601 tgaagatcca tgtgtctatc atttgaattg aatatataat tatatacagt gagatatacc 909661 aattgcagta acaaaatggc aaatatgtat atcagtaata taattagcat ataaaataaa 909721 aaaaaaaaat gcttatttgt cacccgctga ctgcgtttcc ttttgaatta taaaaggttc 909781 cttatggttc tggtccacta gcgttttatt ttcttccttt tcctgtaata tttttaactt 909841 tagctcatgt actttgtgct tgtctatatg tttctcgtat ttttcctttg tcttgaaagt 909901 cctagaacaa ttattgtaaa agcatctgta ttttcttcca acggtattca ataaaaggtt 909961 tagcccattt tcaccagact caagtcgctt ttctaaatcc acttcattct gtaaaaactc 910021 tacattattg ttttcggtaa gttttctcct tttcctcaac ctattggaaa tcttctcttc 910081 atcctgctca ttcgagtgtt tgctattccc cagttgaact ccgtggtctt ggacaagttg 910141 ttgaatatca gaaattttat attttagttc cagtgggata tcttcttccg tatgaataga 910201 cccataatgc gtgagaagat catgttttct agaaaaagac atatcaggac atatatgaca 910261 cttccaattt ttggttacta gtgagtcgtc atgaataatc atgtgcattt gtaaaccatt 910321 ttcccccaca catggtttgc tacaaatagg acattttaat ttaggatgat cattttttat 910381 atgcgattgc aattgtgacc atatccgaaa ctctttgcaa caaccagcaa aagtacattg 910441 gtaaggattt tctacctcag gatcgtgatg tttagaaatg tgatttctta gcctatatgg 910501 cctctgaaag cttttattgc agtgtggaca ggttagttta tgtaaatgaa cagataaaat 910561 atgtgccctt aattgtggat gcttgtagaa tcggaggttg catccttcct ctggacaaat 910621 gaaagatttg gtatgcgtta cttcgtgtcg cttcagttgc tggcgagtcg tcactccttt 910681 tccacaataa gaacattgga atggtttcgt atcagaatgc gtatacaagt gtctctctaa 910741 gtgactcttt ttaacgaagg attttgcaca cttatcacac tgaaatgctc ttaaaccctg 910801 atgtacgctt aattggtgtt cagtcaaaat tgaaggtctt gtaaatgcct tatcacagcc 910861 atcatagtca cagaaatatg tctttggcct attgctcgat gagcttctag ttgatgttaa 910921 actgttcaat gattctgaac tctctgatcg tgatatggga atggtctcct gtttaagttc 910981 ggccagtggc attccttcat tatttagaac ctctcctccc atttgacagc gatttcaaca 911041 gttactactg tgcttaatgc ccttatttga tagttagttc ttcttataat aaataatcat 911101 tgtatattga ttattcgtat agtatgatat ttaattgaaa aaaaaatttt ttttttttta 911161 agaatatcat tcaaaggcat caatcacaac cttgaagaaa ggctaaaaag acacattttg 911221 caggtaacag tgtaaagatt aaggctacaa gtgatcatgt cagactacga ggaggcgtat 911281 gtgcattcat attggagaaa ttgcgtgctt tagttttaat tatatttact aacttctatc 911341 attgtgatac aggtttaacg acggtaatga gaacttcgaa gattttgatg tagagcattt 911401 ttctgatgag gagacttatg aggaaaaacc tcaattcaag gatggtgaaa caaccgatgc 911461 caacggtaag accatcgtta ctggtggtaa tggcccagaa gattttcaac agcatgagca 911521 aataagaaga aagacactta aggaaaaggc catcccaaaa gaccaaagag caactactcc 911581 atacatgacc aaatatgaaa gggcaagaat tttaggtaca agagccctac aaatttccat 911641 gaatgcgcca gtttttgtag atttagaagg tgaaactgat ccattgcgta ttgccatgaa 911701 ggagttggct gaaaagaaaa ttcctttggt tattagaaga tatttaccag atggttcctt 911761 tgaggactgg agtgtggagg aactcattgt ggatttgtga ttacacctgc attttccttt 911821 atgtgtattt gctttgtttg tatattatta taactataaa gaacgattta ttttgtaatg 911881 caaataactg gacgagagaa ccacgctata acctatttgg taataaaaat gtttgtatga 911941 ataaaaaagc tgctgactgc tttctttgat atgtgtatat agaatattta atcggtgatt 912001 gaatctaaga aaagcttacc tctgaaagtt ctctcttcgg tcgcttgctg atttgtagta 912061 aacaatttga aaagtttagc aaattcttcc tcaggatttt caaaaccggc ttcctttaaa 912121 gaatcaatga cctcattcaa gggaacgttt aaatcgtgtc ctcttccaat ggcttttaaa 912181 ctttcttcca attcttcacg ctcgggaaac tgcgataagt tcttccccat gatagataag 912241 aatatgggaa agcttacacc ttcttctcca acttccgcgg tactggtgtc attgtcaggt 912301 accattttgg accattcctc atctgtcaat gtcttcccca atgttgcata tatcttggta 912361 agatctcccc tactaatcag accatcctca tcctcatcca gcatttggaa agcatctttg 912421 agtttattta tgtagtcctg cgtaagttgg ttaaacgtta gcgattcact atggtccata 912481 tctacttcaa gtttgctcaa taaacgattc gaaattactc ttttcttagc tgtgcattgt 912541 atagtttaga aatacgagaa atgtaaaaaa aaaaataaag ttggaaaaca actaactaat 912601 aaaactttct tgtcaagaaa gacactaaga acacagaaaa gaaacacgaa gagcagagga 912661 aatatgtcgg atattaaaca gctattgaag gaagccaaac aagaattgac aaatcgtgac 912721 tatgaagaga ccatcgaaat atcggaaaag gttcttaaac tagatcccga taattatttc 912781 gcacatattt ttctagggaa agcactttcg agtcttccag ctagtaataa tgtcagttca 912841 aatcggaacc tggagagagc tactaatcat tacgtgtccg ctgccaaatt agttcctgat 912901 aaccttttag cgtggaaagg actttttctc ttatttagaa ccactgaggt tgtcccagac 912961 atactttcgt atgatgaata ttttgacctg tgtggccaat atgcagacgc acttttaaag 913021 caggaacagt ctcaagtaga actaataaat gacataaaat tactaaagaa aacgcatcca 913081 gattgtcaaa aagcctttta tcagcatttg aaacctgggt cgctaatggc ggaaactatt 913141 ggtcgtcatc tatctacacc ccaggacgct ttattaaatc ttataaagat actgtctaat 913201 attgaaacaa cggaaatagg taagaccctt agtcagaaca ggttaaaact aaaagctagt 913261 gatcctgatt atcaaattaa actaaattca ttctcctggg aaataattaa aaattcagaa 913321 attgatcagt tatacaacca gttggtaaat attctcgctg acgatcaaaa gagaagtgaa 913381 attgagaacc agtggttaga atatagaatc aaagtgctaa aatcaatgcc gctggatgta 913441 aaaaaagatt ttttcacgaa agttaaggaa atggtcgagg atatggttct tgtgaatcat 913501 caatctttgc ttgcatggca aaagtatttc gaatggacag attacgaaga tctggacaac 913561 atggatgccc cattgataat aaagtacttt aagaaatttc ctaaagatcc attggccatg 913621 atcctctatt cctggctttc ctcaaaacta tcgaaatatg atattaaaag tttggaatcg 913681 gctaataaac cacctgaagg ccataaaaag acggagaagg aaacagatat taaggatgta 913741 gatgagacaa atgaagatga agttaaagat cgcgttgaag atgaagttaa agatcgtgtt 913801 gaagatgaag tcaaagatca agatgaggag gcaaaggaag atgaagaaga agaccttgat 913861 gatatagaaa ttggtttatt agaggaagag gttgtcactg tattgacgga gaatatcgta 913921 aaatgtaaaa ataatatctt agcgcatcgc attctttgtc aatattacct actgaccaag 913981 gagtatgagg cagctttacc atacatcaaa aatggtattt ctttaattgc ctataatata 914041 aaggacctgg gggtacattt gccattaaca aaaagagaat tttctctgga tttggctacc 914101 gtttatacat atgtcgatgc cccaaaggac cacaatgctg cattaaagtt atatgataac 914161 attttatccg gtgattttag taatatacaa gcaaaaatgg gcaaaggtat aatttttatt 914221 gaaaggaaaa attggaagga tgctatgaca ttactaacac aggtgcatga acaatcgcct 914281 aataatctgg aagttttatc tgaactgtca tggagtaaag cccatatggg ttatatggac 914341 gaggcattag ctggcttaga tactgtcatc aagggtatca aaggtatgga tttacgttcg 914401 atagatttca gagcattaaa cttatggagg caagccaaag tttacattat gaagcatgct 914461 tccattaacg atgctaaaca ggaaaacgtc aagtgcgcat tcaaattact cattcagagt 914521 attaaaatat tggacacttt tgctcccgga ttttcgacac tgggcgatat ttattgccac 914581 tattataaag accatttgag ggccttcaaa tgttatttca aagctttcga tctggatgcg 914641 ggggattaca cagcagcgaa gtatattacc gaaacttatg caagcaagcc caattggcaa 914701 gctgcttctt ccatcgcttc aagattaatt aaaggtgaaa aagcaaaggc agaactgcgc 914761 tcaaataact ggccctttag ggtcgtaggg attgctcatt tggaaaagca agaagaaagt 914821 gattctattg agtggtttca atctgcttta cgtgttgatc caaatgatgt agagtcatgg 914881 gtgggcctgg gacaagcata ccacgcgtgt ggtcgtatag aagcatctat caaagttttt 914941 gacaaggcaa ttcaattaag gccctctcat acttttgccc aatactttaa agctatttct 915001 ctatgtgacg taggtgaata tcttgaaagt ttagacattc tggaaaaggt atgtcaagaa 915061 gccgctacag aagagtcatt ccaaattggt ttagtggaag tgcttatgag atgttccttg 915121 gatttatatt cgcaagggtt cttgctcaaa tcagtttcaa ttgcaaagga cactattgaa 915181 cggatcaaga taattatcag tgaattaaaa tgtgagaacc aacaggtttg gatctacctt 915241 tcacaagtac tgagattatt tatttggata gagtcaaagg ttgatacttt acctgttgaa 915301 tcactagtat caatttttga aaattctcaa ttttctggta gtgaagaaat tgattctgtc 915361 gacaatatca aaatcgatac tttactcgat agcactactg atgataatgt gtccattgcg 915421 tgcaagtttt tgatcttagc ttcaaaatat agtgtttcgg atcaaaaatt tacagatata 915481 gcaggaacgg tcagggcctc atactggtat aatataggta tctcagagct tactgctttc 915541 ataacattga aagaaccgca gtatagagat gctgctattt ttgcttttaa gaaatccatt 915601 caattacagt ctaatacaag tgaaacttgg attggtctag ggatagccac tatggacatc 915661 aactttcgtg tctctcaaca ttgctttatt aaagcaactg ctttggaacc gaaggcgaca 915721 aatacatggt tcaacttggc tatgctaggt ttaaagaaaa aggatactga atttgctcaa 915781 caggttctga ataaattaca aagccttgcc ccacaagatt cgtcaccttg gctaggtatg 915841 gccttgattc ttgaggaaca aggagacatt atcggaagtt ctaaactttt tgcacactcc 915901 ttcatattat ctaatggaag gtcaaaggct gcgcaattta tgtatgctaa aaatgtcctt 915961 gagaatcaca ttaataatgg tgacgatgaa agagatattg agacagtgga aaaactaacc 916021 actgcttcaa tagctttaga gcagtttttc aaaaaaagtc ctgatagtca atttgctctt 916081 caatgtgctc ttctaactct tgaaaggtta catcactatg aaaatgcaaa cgaactggct 916141 aatcggttga taggcatttt ggaaaaaaag tttgagaaaa ctcaagatga aagagaactg 916201 tttaattttg cgataattaa aggacaattc gctcgtattc acttaggttt aggaaatttc 916261 gaactctcta ttgaaaacgc tgatctttct caaggtatta tatctgaatc gagcgacgaa 916321 aaatcaatga aaaccaaaat atccaatcac atttgcttag gattaagtta tttcttctta 916381 aacgactttg atcagacttt gaaccaattc caagaactgc taagcatttc aaaggattct 916441 aagcacctag ttgttttaat tgcgaaggtg ctttatgatg taggtgaatc tgacacaaag 916501 gaaattgctt tacaggaact aacagaatat atagccacaa gcggcgcaga cttgttagta 916561 acactaacga ttgcagctat gtcaattcta gacgataagc gtgaagattt aagcattatt 916621 ttagaagaat tgaaagcttt gccattatcc aaacaaataa tagataagca caaagacgca 916681 ccatatctga tagaagaaat tactaagaga ctttatcgta acgataccgg taaacaagta 916741 tggcaaagga gtgcgtactt tttccctaat aacctcaagg tttgggagag attagataag 916801 aatattcaac gaagaatagc ttctaatgga caaaataaag ttactgcgga ggagatgagt 916861 aaactatatt gtgagagtaa gaatttgaga agcatacaaa gaggtatgtt tttgtgccct 916921 tggaacgtta ctgcagtgaa ggcgctaaac gaatgtttct aaaaatttgg attcgagata 916981 gtcaatcaaa ccttaatgta acattagtaa taaattttat cttttctata gagtataaaa 917041 ggttattaga cagagtttat cagctgtata gagtaatcat gccatttgga aaacttccca 917101 aagcgatagc aacctcgata aacgagcgaa aacatttagc tctctttcat tgaccatctt 917161 taattgattc aattcgcttg gtaatagtag ttcgttctct cttcctttaa catcatctct 917221 atttgccttt tttaataatg tagagttttc ttgctttaat ttctcctttt taaaaagtaa 917281 atttgccata ttccattcca agttttgtct catgaaatta taggaatgcg tttctttgca 917341 tctaaacaaa aaaactgccc ttgatgctga tctatcggct gttcttggaa cttcctggat 917401 ttccacagaa ttgtatctaa ttaaagatgc taatgtagat cttatatcct tttccttcat 917461 taacgcagtt gagttgataa ttttctcaga caccagcttg ttatcacgaa tacaacggct 917521 taaacgcatt gctgagggtc ccaacgtaga cgcgataaca tactcataaa cagatgactt 917581 taatactggc attagtttgc tatatggaac atagtaaaca cctggtttgg tttcgttcaa 917641 aaaggggaaa tttgatgatg ctaggatttt taaatgacta tttatcaaag aagctgagtg 917701 aggatcctca gtgtctgcat ccaaatcctc ctcctcttcg tcttcttctt gtgtatctcc 917761 actttcttga agagatttgg aaacagcagc aggtagcgcc gggatcacaa atccatcttc 917821 ggtttttaat tttttactgg gtaatgatgc agcagcgttt gagccagaac gctttttatt 917881 gtcagagggc tttctagata ataagcttcc acgcaagtcc aattctgcgg ggagatgtct 917941 tgccaagtca atagcattaa aggtaagccc tggtgtcttc tcctcaacaa gttcggcttc 918001 gtcttgaaac gattttgctt cctccaaatc ttgtaaaagc ccagtttgag ttagtggatc 918061 tctaatttta ggagactttt gctctgtgag tcttaatgca attttgtaaa cttgagctgt 918121 gacggagccg actcttgtct tggccaagtt aatcaattgt ttagatcttc tacctttcat 918181 aaatctatcc aaattaatcg tcagagagac tgtaggttta acaatcctca atgaggtctt 918241 tggatcaacc gttaagattt gtgaaagctc atttggttta tttatgattt tggcaaaatc 918301 agttttcgca ttcatcttgg cttgggatct tttcttcaaa tcggacaacg gggagtttct 918361 gggaatattt ttgtaatgtt tttcatataa aaattgccag agatcttcga ttggggtata 918421 atgcaatttt gatatttgaa taagatatcc catttcacac agttgcacga atagtgatga 918481 aatggtgtac ttcatggaat ctgacgtgac actacttaga taatcttcca ctgttaagga 918541 ccctaatgat ataacgtttt gtacaatttc agccaccagc tgtttatgct cctcttcgtc 918601 gtttacacgc atttgcgtaa taatttcgtc aataatcaac cctgagtaga gtaaaatgtg 918661 tatcccttcc tcgttatagt aataataagt cgtttttttc ccggatattg ctgtttcttg 918721 caggtactta acacacctta attgagttaa tgagactagt gtcgtcttga cgctgtctac 918781 atccatacca tctattttct ccactaactc gcgcacactc aatctgccca gcgcaaccaa 918841 catcccaatt acagaagctg ctctttcacc cagatgtgcc ttcaccaact ctttgtaaag 918901 aaacaaatcg ggattcaagg ttctctgttc caaggatgat atggtcataa catcttcggg 918961 ggtgaccaac ttctcagatt cgacagtgct ctcacctgtt tggttctctg cactaagcgc 919021 ttctcccagt aactcgtcca tttggatctt gctcaacaaa aatttttccc tattcctgtg 919081 tcagcaattc tctattgttc tcaatatttc ttccactatt attattttga tccaaaatta 919141 tttttttcct tcaatgcgat gagcttttga aaaatttctg atcattccca acgaaccaat 919201 agaaggcccg ccccgtctta tatccgttag cctaccaaat atatatataa agaacaaggg 919261 cctttcctca gagcgtttgc tgacgaagtt ttagaagtta ataaggtttt taacagcagt 919321 gtgctcgaac gattaggacg ggagagttaa aattattaaa aggaaaaaag aagaacgttg 919381 atgttgtcag cagctagatt gcaatttgcc caggggtcag ttagaaggtt gaccgtttcc 919441 gctagagacg cacctactaa aatatctaca ttggctgtta aggtccatgg agggtctcgt 919501 tatgcaacca aggatggtgt ggcccatctt ttaaacagat tcaactttca aaacacgaac 919561 actagatcag ctttgaaatt agtcagagaa tccgaattat tagggggaac ttttaagtct 919621 accttggata gggaatacat cactttgaaa gctacctttt tgaaggacga ccttccctac 919681 tacgtcaatg ccctagcaga cgtgctatac aagactgcct tcaaacctca cgagctcacc 919741 gaatctgttt tgcctgctgc tagatacgat tatgcggtcg ctgaacaatg tccggtaaag 919801 agcgccgaag accaattgta tgccattaca ttcagaaagg gtttaggaaa cccattgtta 919861 tacgatggtg tggaaagagt cagtttgcaa gatatcaagg actttgcgga caaagtctat 919921 accaaggaga accttgaagt tagcggtgaa aatgttgttg aggccgattt gaaaagattt 919981 gttgacgagt cactgttaag cactttgcct gcaggtaagt cattggtgag taaatccgaa 920041 ccaaaattct ttttgggtga agaaaacagg gtaaggttta tcggtgactc cgttgccgcc 920101 attggtatcc cggtaaacaa agcctcccta gctcaatatg aagtattggc caactatttg 920161 acctctgccc tatccgagct ttccggttta atcagctcgg ctaaacttga taaattcact 920221 gacggcggcc tatttactct gtttgtaaga gaccaggaca gcgccgtggt atcttccaac 920281 atcaagaaaa ttgttgcgga tttgaagaag ggcaaggact tatcccctgc aataaattac 920341 acaaagttaa agaatgccgt ccaaaatgaa tctgtttcca gcccaattga actaaatttt 920401 gacgccgtga aggactttaa gttgggaaaa ttcaactatg tagccgtcgg tgatgtttcc 920461 aacttgccat atttggacga attgtaagag gaaagtattt gtacaaaacg aaaaactaaa 920521 ggcaaatata tatatagatg ttgccgcgca cctttttttt aatgaatatt cacacaaata 920581 ttgaaaataa aaacaaacaa aattcaaata acaacatgta agaccaaaaa aaaatccctc 920641 attatttatt ccttaccctt tccaaattct tactatacta gtaaatatat atttaattat 920701 ccttttttct acttcagcat acaatccttc ttttgccgca ggtttatagt tagacccctc 920761 aattctgtca agtttcagtg gtacgttatt ttatgtctca tctcacgatc ctggcaaaaa 920821 aagaaaggca tgtaatttga ggaggcgatt caccctcatt tttacgcaac aacaatgctg 920881 tgtggcttac acgcctctgc gtacatatct acatatttaa cggtcctgta ttttcaagca 920941 cgcaaggctg aaataaacgg ttgtttgctt atgcgcgatg cactccgccg aacatcaccg 921001 caaaagcacc gtaggcggag atctcccagc tagtatgggc atgacggaac cacgatttcc 921061 agatatagat acttaaaagc actaaaaggt ctatacataa aacgcagact tacgtaagat 921121 acatagcaac tgccgatatg gacgccgcca tgccgaatga caaagggaga atgtagtact 921181 aattgatatc gtcttatcct ctcaggaatg caaacttaaa acatactttc tcccgtccta 921241 acaacgccgg ttgtcgacga taaatacccc aagaaatgcc cgcacagaat ctcctccgtt 921301 aggtggtcat gccccgaggg tgcgaggttg tttcctgcac ggtaaatcgg gatgccatga 921361 aagccggccc tccccacgcg tcccctaatt tttttccaag tgaatatctg catcggccac 921421 cgttttatat tacttcgata agcttgcctt aaactcatta ttgccgtcgt ttatccctca 921481 aagcttaatc ttacaagaat tagaaagaag aaaagtttat tcgtatagac ttccttatgc 921541 ctgatgtcct tccaccctct tacacagtag gattagtcta gaagtggtaa attgcaggat 921601 agcatatacg cgacaaggaa aagaaagaag gaaaaatatt ttacgtcgga aattgtgtga 921661 tatgccgttt gaattcgagg tatattaagc gcagtgcttt tccctgcatc gcattctgtc 921721 tgttcttccg agtgtcgatt cccacaattc gtcttgtcct tttgatattt tgtttttttt 921781 ttccttctct ttttttattc tttgtatttg gtgctgtctg tcaatacggc acataaagta 921841 acatgtaatt aactataaca tgtcttcgaa cgattcgaac gataccgaca agcaacatac 921901 acgtctggat cctaccggtg tggacgacgc ctacatccct ccggagcagc cggaaacaaa 921961 gcaccatcgc tttaaaatct ctagggacac cctgagagac cactttatcg ctgcggtcgg 922021 tgagttctgc ggcacattca tgtttttatg gtgcgcttac gttatctgca atgtcgctaa 922081 ccatgatgtc gcactcgttg cagcgcctga cggttcccat ccgggtcaat tgattatgat 922141 tgccatcggt ttcggatttt ccgtcatgtt ttctatctgg tgttttgccg gtgtctctgg 922201 tggggctttg aatcctgcta tgtcgctttc gctgtgcttg gcgagagccg tctctcctac 922261 aagatgtgtc gttatgtggg tttcgcagat tgttgctgga atggccgctg gaggcgctgc 922321 aagcgccatg acacctggtg aagtcctctt tgccaattct ttgggcctgg gctgctctag 922381 gacgaggggt ctgttcctgg agatgttcgg caccgctatc ctatgtttaa cagtcttaat 922441 gacggctgtg gagaagcgtg aaaccaactt tatggctgcg ctgcccatcg gcatctccct 922501 gtttatcgca cacgtcgctt tgactgcata cacaggcaca ggtgtcaacc ctgcgaggtc 922561 cttgggtgct gctgtcgcag ccagatactt ccctcattac cactggattt attggattgg 922621 cacgctgtta ggatccattt tagcatggtc tgtatggcaa ttattgcaaa tcttagacta 922681 cacaacctac gttaccgctg aaaaggctgc cagcaccaag gaaaaagctc aaaaaaaagg 922741 tgaaaccagc agttcctctg ctgtggctga agtctaattt ttccctcctt ttctttattt 922801 ctcgctcact agcacttaat gttataatac tcggcaaaaa ctagtaagat taattgtttt 922861 taattttttt ttttctatac atccatacta ctgaggtaat tagtgttttt aatatccctt 922921 cctcttgtat aatatttttg gggctttata gccgaccttg acgtatagca gctgagctct 922981 atggtttgac tcatccgtac accaatacac gcttggtgtg cccagtttat cagcttcgtc 923041 gtagacaaat tggattagtt tgccgcccgc gcctttgacc ctagaattct catcaacata 923101 gagatcgttg atgtatatct tgtccttgaa atcccaagta gtcatatggt tgaaaaagtt 923161 tatcattcca ataatttttt cgctcgaact ttccacagct acggctgccc acattttaat 923221 gttaggatct aggaatctgc cgaaattgaa atcgtccaag tcatcgggaa aagagacttc 923281 ataaaaatct tgataggatt tccaaagcct ttgccaaccc tccttatcgt tttcggttac 923341 aaaccttacg gtaatgttat cttcgctagt gttggacatg ctacacagaa agggctgttt 923401 gctttcttgg catataaaat actaagagca atacttagcc ctttttgctc tatttatagc 923461 gttccctctc ttaatgattg ccgctcccct aatataattg gtagttcttg ccacccgtta 923521 gttccgtcca taaaaatgtt caaccaataa aagcaaatca agaagtgact gagaagtaca 923581 atgaactatg acgttaaaag gctaacccaa tgcagaaatt aaatagaaat aaatacattg 923641 tgtagtcggc ctgtaacttg tatttcgcaa acgtcttata aaggcaagaa aatttcaaat 923701 gttcgaaatc tgacatcagc cgcatgctat gttgtcaatc tctctcaata ctcggctggc 923761 ttaaccctga atcatcccaa aaaacggtga tactgtattt gaatatgctt caaccggagt 923821 aattatccag tagtgcaacg catctcattc caacttgaaa tatacgttta caaaactatt 923881 taccacttgt atttctgcaa taataccaaa attcatgcaa aataaacacc atcattactt 923941 gtagttggaa gcaaaaaata ttcttgattg attttcaatt gccaggctcc ttatcacttc 924001 gtcgatgagc caaaaaaaaa tgtagttcct attctggtat caaagcattt ttctttattg 924061 ataacatccg catacacaga gaaaaggcga gaagcatgaa aagtgtcaaa aatattgaac 924121 tagagtgtac tgttatagtt ttggcaggta tgaagacaaa atgatggctt tttacatatc 924181 aaagtaactc tgtactatag atagaagaat aaaaactaaa tacatgcagg tgactgatag 924241 aaaagacaag tgcaggggag aaaaaaaaat aaagaaatga tagcgttcta agaaaagttc 924301 tagtcatgga tagtgtcctg gagcatagcc gaaatagcca tttgctgtat cagttatgtt 924361 ctttagagga tagccaacgc catcggcacc agcatacgga actgtattgc cccaccaatt 924421 aaaagctgtg tctttatatt ggacagcaaa gaaaatgata atagctgata aaaccaagcc 924481 cgttgaaaag cctgccgata aaacataatt atatttctcc cacagattta aatggtgtct 924541 tttcatgtag tactgggaaa tgtaactaac aatcatacca gaagtgtaat acatcaggtt 924601 atatggaggg ctcatattaa gcattccacc tacaaataac attgggtcaa aatatctggg 924661 ataaaactta ccccagcgct tccaaacacc aaaaaatatg ccaatgcatg cgcctatcaa 924721 ccaacaccat ttaaatattg gataaatgta attgaaaatt ctttttggcc caattgcacc 924781 ccagacaacg gaagcattat agtaggtcac agcatcagga caggtgaatt ttgcgttttg 924841 atgaggtgtg caaaagtctt tgatattgga gatttgccaa ttcagaacac ctagattgac 924901 aaatatctga atgaaaacta taacacattg tcccctgaat agcgccattg gcggaatctt 924961 acaataatgc gctattttta agttagaaac gtaattatct gcttggccgt cgatgttata 925021 accaaaagcc ttcaaaatca ttatggcgat tggattacct ggtaaagcgt accccatcac 925081 catttcaatt agtagattca aaccaaacga ataaccagtg gttgcttgaa ggatagtagt 925141 tggaatcaag aaaacaaaat taaatcctaa acaaacaaaa agaccccaaa ctggtgtatt 925201 tgttgggtag tgctctacaa cagctattcc aacaacaagt gaacctatca atatggcaaa 925261 ataccaccaa tctggaactt ctttatagtt tttcatggca ttagaatgtg ggtcatcata 925321 atcgtcgagc gccctgtaat cgcttttgaa cattgtgacc caagatttaa gttttctcat 925381 ggcccacaaa ttcaaagccc aatctttgaa agcattgaac aataactttg agtgtacaat 925441 aaacgaccat gtaatcatca gaggatatgc gcaaatgaaa gcaccatatg ataccaaatt 925501 tccagcacta tagtatggtg gcgagtagct ttgatatttt ttcacatcta gcttattgtc 925561 actgtctaat acctcagtaa ctttaaagga atggccagta ttagtataca aagaatttgt 925621 gaatattggc aggtattggc aactcatata attactatag tatactgcaa taacaattaa 925681 agctgctaat atgcaaccaa gatattgtgt taagtatgac caaaatgggt aaactaaagg 925741 agaattaaac gaaataacat tccagtcaaa agatgagata ggattaatcc caagaccagt 925801 gactcctccc gtgatgtttg cgagattaat gttacttggc ttgatccagg tcatccaatt 925861 gaaagtgttt agaatattaa taatgtaagt gggaaaccag ttatagatga acatgataaa 925921 aaaagtcaag aaaaagaatt tatacctgct cattccagat tcatgctttt ctttacccaa 925981 tagtgccttg ttgatagcaa tagttggcat gactgttggc catagtgcac gggctggata 926041 aacaacgaat tttctaagga tgccagcaaa tccaaatcca ataaattgta cggataacga 926101 aagtaaaaat tggtagccaa acgagaaagc agaatggtaa aagagttttt gcgttagaat 926161 attgtaatga gtatagaacg cgccttgaca aattgcatat aacaaggttg aaaacatttg 926221 ctctttttgg gtccatggtt tatcgatatt gataccatac tttctgcccc tgatggttat 926281 agtccaacag gggatagttt tagcccaagc cttaccacag atatataaaa acatttggat 926341 aattggagta ttcagtgaaa ttgaaaccac cctgtgtgaa aaaaactcat taaatcctga 926401 accgatgaca gaccaaatta ttgccagaaa atatgctcgg aatgtctcca ctggaatggt 926461 gggatcatct tctggatcaa caacagctct aacctcttgg taaggcgaat gaaatttaat 926521 agcagaagca aatgctctaa tgtcaaagct atcatattca tctatcccct cttttgaatc 926581 caagtcctcc aagtcaacca atctcttcca ctcctcatat tgatcgtgtg gaatgttctc 926641 atcatccttg aaatagatga tagagtcttt tagtattttg aaggaatcct caagtgtcaa 926701 ttcaggcatt tttttgagga tatacgcaac gtcttccgga atatcataaa gagtgcgatt 926761 ttcataaccc agcttcttca taaagtgcag tatctgttca tccgtatacc actgagaaaa 926821 gtctgatgaa tgatttgaaa gcctctcaga atactcagca ccctcggcgt aatcaacagt 926881 accttttgtg gataccttct catcaattat aactttatct ttgactgttt cactcataat 926941 ttctaataat tcaacagcaa tattgcgtat aacaaaccct actagttgta gaataagcta 927001 atatgttcgt ttctgctatt aaaaaaatgc cgccgttgtt tagacgttca atgtatgatt 927061 gtaagtgttt caaatattat tttttgggat gtttcgatag gaatgaatat aagtaacaac 927121 tgacttgaga catgacttaa gtttacacag gatagtgttc cattcccatt tataaatttt 927181 tttgaagcga gaagaaacct agcaagttga tatcaatatt ttttttaatg ttacttatct 927241 tcattgctaa taattcgtga aatgattgaa aatttccaat ccatgaacat tcagaagtaa 927301 gataacagcg tccaattgta aaagaacgct attattattg tagataagag aataaactta 927361 aataatcgaa ggtgttacga atcttcataa aacccaatgg gctgatattg acaaccgcaa 927421 tggcgattca cgtgttcggt aaccacaaca ggggccaaga ggaaaacaaa ctacatcaat 927481 ttttgcaaaa ggttaacaac gaaatgtggg attattgaaa attataacga agaaactacg 927541 tcggacagca accccccgat ttttgtcggt tgcttttact gacaccatga tgtgaaccaa 927601 attttctttt ggtattcctc gcatagtgtt gacttctttt accatgataa aaataatgag 927661 ataagaagtg ttgcagtaat attatgtgtc acaccagcgt ggctgccata tttgagacgg 927721 attcgtccgg tggatgtgat ggatccgttt aatgctgatc tctcctgcat tttttgtgaa 927781 aaatcagata tcaattattg gtctatctgc ttttgcctgt ttgttttttt ttcattatag 927841 agttcctcag tgagtgggat tgatgatgcg cacggcacaa ttgaagcatt tgcttatcaa 927901 aacataaata tctccgtacc caaataggaa aaacgcgtta atgcaaagtt gacacgttca 927961 gttactattt cctgaaataa taatacagcc cacaaaaacc caccaatgac gcttttgttg 928021 ctgaatcaga cgttaagtgc tgctgcctcc tctgttctgc gccgccggtt gtctcattac 928081 cttttctgcc tatgatgatt gtattgcaag gcccgagtgg ttgcgtatgc cacgtacgaa 928141 aagttgttac cgtgccgtca catcccctgc aaagaatgtg gtacggcaca ctcctgctag 928201 cttgaggccc tattccaatg gcaattgaga tgctgctttc tcctcttaca atgtatgttg 928261 atgcttccac taaaagaggg atgagagaat tcatttgact gtgcagtcaa atctgtgatc 928321 tttctattct tgcttatcta tattctgccc tatttatttt tagtaaagtt tcgtatttac 928381 atttttcatc atagatcgca ccagcgcgtg gggctctttc attatcatct caactaaatg 928441 acatacattg caaatacgtg aaatgagctg actcaaaaag aaatattctg aactgtgaat 928501 accaaacaaa cttaaaatag ctgaaattca cgtgttgaat taccgcatcg gttaaggaaa 928561 gggaaagttt cttctctaaa taaggaggag cctttgcaca tatgtagatt atgtaaatac 928621 tatactcttt ttttgctttt agtacttggt atcctactaa atctttattt tctttcgtta 928681 gtgaaaaata tgaattgaag gatcagttcc ttcaaaaagg taagaaaaga aatggaccat 928741 tcgattaatg ctggcaccaa cattccacag cacggaatac aatttttggt gtcctttact 928801 tcaagatttg ttactacgtg cggcttagaa taacttcatt atttatctaa acgacccata 928861 attttcgatg ctaaagtcta aagttgagca ggtaagttta ttaaaaacgt ctttttcatt 928921 actgctctag cgggtaaaag tcaatgacag cagacgcggc aagttgtgac gcctcatcgg 928981 atccaagaaa catttatttt tgcgtgcacg agtaatctag cgaaacaatt tccaaaaaat 929041 aagtgaaaga atatctacta atgcttagga ttaccaaatt caaaaataac ccttttaaag 929101 tataaacttt gcatttcaga gattctctgg catggcaaat attacgaata aggaaagcaa 929161 ggtaagatat attagaagga ccaaattgtt aaagagacat ctaacaggtg agtttgaaaa 929221 gtaatatatg gaaaggatgg taatacagat ttagcgcaaa taatagttgt attatcaaat 929281 gaaatgtgaa cttttttata tgaaagtcca tagggtagac tactgtcgcc ataatttcgt 929341 agaagaagag aaattcatga taggcgtcag cattattaca ggcgcgggtc ttaaatttat 929401 ggaactataa ttgttgtaat taagatgagg ccaagattag gtgggtaata tgtttcatgc 929461 tttttactac tactgcaaga tttttttttc cacaaagttt atttgttggc atttctagtt 929521 acgaaactct cgttgctaac atcatgttag tctgacaagt tacatattcg tttcgacgtc 929581 gccattctac gcacttaggc caaataacac atctctttta catttgaaat tgctaccatt 929641 tattcctgtt cgatcttaag attgactaaa ccataatccg agcctaatat tcacgtttag 929701 gcggggggta ctaaatcaca aaaaacaagt ggcgagcgaa gaccttttca attctaataa 929761 ctcagttaca ccctcaactt gtaatcaatg tacaaaacac agtaaaatcg aagataagag 929821 atgtaaaacc atagagacaa tttgaaaacc tataaacaca cgttttatac tttatcgtta 929881 ttacgaaaaa tcaatttttg ctcgaccaaa agcagccttc ggactgatat atctaggtcc 929941 gttagtttag tagctgttga ggtcattgta acctcatgta cacccttagg atcttgaagt 930001 tgctgctctt tacttcagag catctctcat ttcgatgact tcgcattttt ttgaatactg 930061 ccttcccact cccatctttt acagcttcct aacgatacta cgatactacg atgctacata 930121 ttacagagat acaaaataat aactcttata agaaagaaaa ataatatgta ttgtacaaat 930181 tacactatta acgaacaaga aatgggctct agtggaagag ttaaatcaca gagaaggggt 930241 taaatatctc tttgagtaaa aagtttaaag agcaaagatt atttgttttg taagaaccat 930301 tgcagataac ttttcctgtt tcttacctcc gaacaaatcc atgtcgccca tatcaccaaa 930361 ctttgaacca tgaccatgtt ggaggtacgc aattatctgt atcattatag atcaatttag 930421 tgctcggaag tcaagtgcac aatgaaagtc atgcaaaaag tttgtggctt agcatctcgt 930481 gaggatatgg aagactatat ggaaggctgc tctgtttagt cacatgattc tttcccaact 930541 ctttcgccag cttgcgtgtt cttttttact ctagcaaaaa aatcgagccg gagttaatga 930601 ccggaaatac acggatttca tattaaagtt ttttgagcaa cacgtaaggt aaaagtcaca 930661 atcatgttca cctaagtgat atcgtacgat agttgcgtat ctgtgctaat actcgccgaa 930721 acgtaatcct ttaaaagtac cttcgtatca ttgcatcatt agagacgcct aataggaatg 930781 ttataggtgt atccaaatct caccttgaat gtgcttggca taagtataca actgtagcat 930841 aaagaaccct cgttttactt tctccggctt atgcaaagta taagttaatc cctgcctagt 930901 ttttttctca ccgtttttcg tagtttaaat ctgcaatgca gatttaaagt ttttcttttc 930961 tctagcagca ctcgtggaag taaaagattt tttctttcaa attgcctaca ccgaaggatg 931021 tgaacgattg ccttcttgaa ctcaaactat ggaagtcttc gtatgatttt agatgatttg 931081 ttttggctaa tatcaaagta tccacgtata tccccatgac accgcgatac atacttgcga 931141 tgcggcaatt aaaagtcgtc attgtattgt tcacacttaa aaggttcaaa cctgcaatat 931201 cgtccggatg actgcttgcg ttactatata ttttttgctg taattcaggc cactccgggt 931261 ttaatcatcc gttcctgtat attaatacta tatacggaaa gcagagacag agcttcgaga 931321 agttttatat cctgtggaaa aaaactaaca atcaaaattt ctgccttgaa ggaatatgag 931381 tattgtaaga cagtcatgtg attgctgtcg cgttcgtcga gtgaagtgtg ataggaatag 931441 accgtgtgat cgttgccgtc agcgcaattt gagatgcact tatttacaac cgttaaggaa 931501 acgaggtccc aagtccatcg gagaaagcaa ccttgaaaga gcagctgaaa tacagatggt 931561 gactgtaaac aataacatca tggcggcccc agtaatgtat aaaaaggttc caaagaaggt 931621 gattgatcaa tgtttgagac tatatcacga tcaactatac gtgatttggc caatgctcag 931681 ttacgatgat ctttacaagc ttttggagga aaattatgag gactgcagca cttattggtt 931741 tttagtgtct ctatctgcag caactcttag tgatctgcat acaaaaatag aatacaagaa 931801 gggatttttt tttgctggag aacaattgtg taatctttgt atgtcatcgc gacggttttt 931861 cgacgatctc agtaatagtg atatatttcg aattatgaca tattattgtt tgcatcgttg 931921 ttatgcacag tttgctgata caagaacctc atacagactt tcttgtgagg ctattggcct 931981 cataaaaata gctggatttc atcgggaaga aacttatgag tttcttccat ttggtgagca 932041 acaacttata agaaaggttt actatctgct tctcatgaca gagaggtact atgccgtata 932101 cattaaatgt gtaacaagtt tggataccac tatatctcca ccacaacccg aaatcgtaac 932161 tgattcccga ctttctttgg atagttttct tgaggtgatt aaagtattca ctgttcctgg 932221 gaaatacttt tacgatgcct tagctaccaa cagtgttaat ggttcctata ctgaagactc 932281 tctaaaaagg atatggaatg aacttcacat aagctcactt gatatagagc catactctta 932341 cggatacata gactatctct tttctcggca ctgggtcagg actctagcat ggaagttggt 932401 actaaataag aaggatatgc ggatgaattt tttttcgaat actaacgcca cacacattcc 932461 agtcgaaata gccaaggata tgttacagga tacactttta actccaatcg acctatatga 932521 tgtgcatggt cctgtgatac caatgaaggc gctagaaata gccaatgcat tggtagacgt 932581 cgtaagtaag tatgatcaca atatgaagtt ggaggcttgg aatattttgt gcgatgtatc 932641 taagttcgtt ttctccctga aacattgcaa tcataaaatg tttcaaaggt tttcaactaa 932701 atgtcagagt gctctaatcg atttgcctat ctctagacca ctgcgcctaa atgatgattc 932761 caaggatgaa gtcgacatta ttccctaaat gaactttatc ttcttacagt ttcaacatct 932821 tgtgacctga tgattttcct caaatgaact tttgcgtttt cattgagaaa atttcattat 932881 actttatttt ttttataaat gggtaccaag gcattaaata tagatctggt ttactaatct 932941 gaagaaattg ttttcaacca cataatttgt gcaatttggc gctatacaaa gcccatgttg 933001 gctacattag tctttgaatc ctttagattg cctgaatcaa tagctcattc aaaatatttt 933061 ggacaatcga tagttaactg taacatgtgc tgctatatag tggcaatcta gatgcatgta 933121 tcttatatga ttaagtataa aagaaccaca gcaaagctaa acgtaaataa gtagtttaga 933181 aagtactgga tatgagttaa gaatctgtta attgagcatg acatgaaaat tttgtattaa 933241 agcaatatga gtcgtcacat taaatatatg aaactacggg aattaccatc atattggtca 933301 tgattaataa taaaccaatc agcatgtttt tacctctatt atattagtct tggacccgta 933361 ttcaaccttc attaatatta tctttttacc tttgttcata aacacaatac attgtttttg 933421 caaaatataa caaaaaagat taaggaagag gaccatgtac actacgatct tacttttgaa 933481 atagaatttg tttatttttt caagatgtta aacgaagatg gtgagtaata ttcacaaaac 933541 attgtaaaaa tattacttgc ttcattctgc gaattgttca aacccgtaaa gaaaatttct 933601 agtatatgat atatgcataa tatcaatagc tttacaaaaa tagaatccga aaactatcta 933661 gaagtttact cgtttctcaa gttttattta acaaaacata gacgagcttt atttcgtgtg 933721 aagaagtgaa gaagctttaa caaaactgta tttctaaaag aacgttacta tacaataaat 933781 tataaaactg cattaaccaa tgaaaaaaag cactattaat cgaaactcga atatgcaata 933841 ttgttaatgt aaattaagct atcggtccgt ttatttttct atcgaaaagc ggcttagtta 933901 gaatggttga taaacggctg cgcttcgtaa aaagaaatga catcttggaa ctactttaaa 933961 tagaagttta aatctcatga tcatgctcat ctgtttgtac aacacataag cttcaccgtc 934021 agacatatat gcaatgaaga gtactttgag tttaacttta tgtgttatat cgcttctatt 934081 aacccttttt ctggcggcct tggatattgt tatagtggtt actttatatg atacaattgg 934141 cattaagttc catgacttcg gcaatattgg ttggttagtt actggatatg ctctttctaa 934201 tgctgttttc atgttattat ggggtcgctt ggccgaaata cttggtacaa aggagtgctt 934261 aatgatttct gttattgtat ttgaaatagg gtctttgatt tctgctcttt cgaattcaat 934321 ggcgactctg attagcggaa gagtcgttgc tgggtttgga ggaagtggaa ttgaatcact 934381 tgcttttgta gttggaacat ccattgtccg agaaaaccat agaggaatta tgataacggc 934441 actcgctata tcgtatgtca ttgcagaggg agtcgggcct tttattggtg gtgcatttaa 934501 tgaacatttg tcttggagat ggtgctttta tataaatctt ccaatcggtg cgtttgcgtt 934561 cataatattg gcattttgta acacatctgg agaaccacat caaaaaatgt ggctaccatc 934621 aaaaatcaaa aaaattatga actatgacta tggcgaatta ttgaaagcaa gtttttggaa 934681 gaatacattt gaagtacttg tatttaaact agacatggtt gggattattt tatcttcagc 934741 aggctttaca ctactgatgt taggtctttc atttggtgga aacaacttcc catggaattc 934801 gggtatcatt atttgctttt ttaccgtggg ccctatctta ttgttactat tttgtgctta 934861 cgactttcat tttctgtcat tatcggggct tcactatgac aacaagcgga tcaaaccgtt 934921 actgacatgg aatattgcct caaattgtgg catatttaca agctccataa caggattcct 934981 ttcttgcttt gcttatgaat tacagtctgc ttatttagtc cagctttatc aactagtatt 935041 taaaaaaaag cctacattag cgagtataca tctttgggaa ctatcaattc cagctatgat 935101 tgcaactatg gccatagcat atctaaattc aaaatatggc atcatcaaac cggcaattgt 935161 ttttggtgtg ctttgtggga ttgttggatc tggtttattt acgctaatca atggcgaact 935221 ctctcagtca ataggttatt caattctccc aggaatagct tttggtagta ttttccaagc 935281 aacgttatta agctcccagg tgcagataac atcagacgat ccagactttc aaaacaagtt 935341 tattgaagtc acagctttca actcgttcgc caaatccttg ggctttgcgt ttggagggaa 935401 tatgggggca atgatattca ctgcatcact caaaaaccag atgcgctctt cccaattaaa 935461 cataccacaa tttacgtctg tagaaacact tttagcgtat agcacagaac attatgatgg 935521 cccccaatct tcactatcaa agttcataaa cacagctatc catgacgttt tttactgcgc 935581 cttaggatgc tatgctcttt cattcttctt tggaatattc acttcgagta agaaaacaac 935641 aatatcagcc aaaaagcaac aatgaacaat tttccaacgt ataaattaac ttatcgtagt 935701 tcgataaaac tagacagtac ttatatatta tctaacatca gatggtttgt ctttcattat 935761 ttatttagtg attaatgcta gctttaagca agcttagttg cctcaagaaa gattaatatt 935821 aagctactga ggatatagca ttcgaatata aagatataat caaagctcat aattacaaaa 935881 taccctgtga ttaggatatc attattacta acaacaccgt tcctaaacta gcagaaagtt 935941 gaccaactgt ataaaaatta aatttgttcg taaatacata tacataaaat ccgcattaaa 936001 tgtggacttt cagttgagca agtgttaatg aatatcgtag gatagcaaat gaagattcga 936061 atttgatgag gtctcttgtt ccgagaacta ttgtttaagc caaaccagat tcagtgtctg 936121 tactaaacag ttgtcacaga aaggtggtag ctttactttc cgtacattaa atacagaaaa 936181 attaccactt ctgttgaaaa tactgttttg tgggttggga taatataatc gtatataata 936241 tcaataaaac tgttaataaa ctctcgagga tctgatgttg atttttcccg tcattccaca 936301 aactctgatg cctgaaaagg tgaaatataa aaagcgggac attgataatc cttggattat 936361 tccatctcca atattggaac aatagagatc gtgagtcttg aactatagct agtaaaggca 936421 ttttcttttt gccgcccttt cagtgttact ttctttcaac tagtttatcg atacttttcg 936481 ggcttacagc tcctatgtgg atatgtgaat actcatgctg acactgaagg attattggta 936541 ttggccggtt gtgttttttc tatacatagc aatagttcaa atgtcaatga ccaaaagaat 936601 aggaattttt ttaaaataca aggctgatga agtatcagtt actagatgac cactcttata 936661 aaaaaactca gaaatcttcc aaacattgtc tgctcaaaga ggtacctatt cgttttctgt 936721 gcaacttcat caatttctca aaaaaatctc attgatgttc tcttaatgga ttgcccccct 936781 gagttgtacg ctggacccat tgactttgac tggtagtgtc agaacaatct tgaatgatta 936841 aaaattggta ggtccccttg ttttttgttt tgtatccatc caatggtatg attctttata 936901 ttttattaaa cttatactcg ggaaatctta aaagagctgc tttgacgaac gcttataagt 936961 acatacagaa attggaaatc attatcgctt atgttctgtg acctactaat tgcattcttc 937021 cttacgtaaa aagacctgaa actaaccaat aaactgccat ggatacgtcc atacgaagga 937081 cgataaatca atttgtaata gtccaaaaaa attccatcaa atatcagctc caaattggca 937141 actgtttaac ttgcgttgcc cgattacttg atatccctta ttgtgaacat catgacaaaa 937201 cgaaatgaga aaagaccttt cctttccatt aatcattagt aattaaaaat ttcttaactt 937261 cttttcgatc aattacaata tatgtatact tgcgtgcaca ttgcaatttt acttaaccat 937321 gcatagcaga ggctcttcta ctttactata atatgtttac aacaaagtta taaaaagttt 937381 tctcaaacct tttccatggt gaatggataa ctaagggttc caatcaatgt tatgaagaat 937441 tccaagttaa tcgacgaaaa gcgtttggaa aggaattata taaacgtaaa catgaaaaat 937501 attcatcgaa tactccacat cgatcgtatt acagtgtttt agtaaatgtt tgtatttgaa 937561 tcaaagtttc agcatttgtt ctacactgat aaaatcatgg ttctagtata gtgaaacata 937621 cgcccaagtt atcctagtac aagaccgcca tattgtgctc ataatcggga acaatgaaaa 937681 taacacccta acaattgctg aaacttgtcg tacgcgatcc ctaattacat tatcaagcat 937741 tcagcattgg tcaatacctc aatacctcga caagaaaaaa gaaatagaca cgtgtatgtc 937801 aaggcattaa gaagggtatc aggcctagtg ctcgcctctt gccttcccaa tttgttgaac 937861 atctttgaca tataatttga ttttgaaata gttattggac ttccatttta aataaaggct 937921 ctatcattaa ctatacagaa tatactagta acgtgaatac tagtcgatag acgataaatt 937981 aatacttttt ccaataaaat ctaaacgcat gcaagtacat aaataggcga aggtatctga 938041 ccgtaataat cttcacgcca tctatataaa taaatgaaaa attcggcttt taacttatat 938101 attaacaata agaaagacaa tgttgcgctg tgcttacagg aagaatatta taattttgac 938161 gaaaagacct taatgaaatg cttgaggcta attaaaatat caaaattaga acacgtagca 938221 cttttcttaa gttctgttcc caaaatttca aggtcaaatg tgttaacctt tggatgcact 938281 ttcataaaac tccaaatatc catcgcactt aataggacgt cccctccaaa agcatccact 938341 gtataatact gtcttggatg gaaaccctgc ctaatcacca tgctcgctgc cgctgtttct 938401 attgcattag tgttttcagt aatgaaatta tttggctcct ttatttcagt cccactaaac 938461 tccaaaaagg tactatcaag ttccccatta aagtcaccaa acgtatgaat ctcactcatt 938521 gcatcattta gaaaagaata gcctggtatg tcatttgaga gattcgtaca gcctatggga 938581 tagaaggacc gatcaaagga attcaacggt gacggcactg tacaattctt tccaacacac 938641 actgagagca gttgcttgaa aaatacgtag cattgttgta tttcaaggga attatatgtg 938701 gaggaaagaa ccacactacc atcgagagtg ttacatgtgg gcggtttttc ttcacaacag 938761 gccttactaa tgttccgttc atcagaaggc atgttcctct cagtcaaaag actcctcaac 938821 ataaaatgga gaagttcatt ttccttcttt aatatgtgaa tttgatcatt tgttaccgtt 938881 agctgagctt ctttcttctc tagttcttct aatctttcca actttcgttt tctaaatgcg 938941 ttttgggatg ctctaagttg cgcagctctc ttatttttag gtggagtaag tgaaggcttc 939001 ctgccgcctt ttcttccacg cggttttgcc attatcttgg tcacttatct tccgttttga 939061 catgtttttt caacggccgc tccttaaaga ccatccgcat gctagaatta tatactaata 939121 tgattttgta aagataggaa tattataatt ataattatat ttaatttaat aagaaaagaa 939181 acgaaaaaaa aaaaaaaaat ggaattaaaa agttttgccg tacataaaat attgaaaaga 939241 cttttacatt aatgctggaa caataaagct tgaggagctc aaccactaac aatcaattta 939301 aggttactct ctctacaatg ggtctcccaa gcgtaaaaac ctccaacgag gatgcaactc 939361 tcaaacttac ttgtaatatc ttcttcttgt aagtaggttt cgaatttagc agctactttt 939421 ggtcccctat tcttggaccc agtacaatga aatatcactt tgacgaattg agaacttgag 939481 aaagtatcgg ataaaccttt aattaattga ttcagttgct tctctgtaat ctgtgctgtt 939541 actggaacat gccaagcgtt tgtaatatga tcacgtgcaa aatcttctct tcgaagatca 939601 acaacttgaa aatccttcct ctgattttca attaggccct tgagttgcct agacgttatg 939661 aaacttacca ttacgcttgc tggattgtca agttttcctc aatattagtt tgttatacat 939721 tagtttttat accgactttt caaaagtgtt gatttaaaat caaattttga atgctcttaa 939781 ttatcttttt gtttgattaa taatcaactt tagcggcaac gctccttaca taattataat 939841 gtaaacggaa aagaatataa atgaatgctc tcgttgtaat tcaagagaac ccaaccaaca 939901 aatcatcagg ttagtagaat aatgtcagaa gatcaaaaaa gtgaaaattc ggtaccttct 939961 aaggttaata tggtgaatcg caccgatata ctgactacga tcaagtcatt gtcatggctt 940021 gacttgatgt tgccatttac tataattctc tccataatca ttgcagtaat aatttctgtc 940081 tatgtgcctt cttcccgtca cacttttgac gctgaaggtc atcccaatct aatgggagtg 940141 tccattcctt tgactgttgg tatgattgta atgatgattc ccccgatctg caaagtttcc 940201 tgggagtcta ttcacaagta cttctacagg agctatataa ggaagcaact agccctctcg 940261 ttatttttga attgggtcat cggtcctttg ttgatgacag cattggcgtg gatggcgcta 940321 ttcgattata aggaataccg tcaaggcatt attatgatcg gagtagctag atgcattgcc 940381 atggtgctaa tttggaatca gattgctgga ggagacaatg atctctgcgt cgtgcttgtt 940441 attacaaact cgcttttaca gatggtatta tatgcaccat tgcagatatt ttactgttat 940501 gttatttctc atgaccacct gaatacttca aatagggtat tattcgaaga ggttgcaaag 940561 tctgtcggag tttttctcgg cataccactg ggaattggca ttatcatacg tttgggaagt 940621 cttaccatag ctggtaaaag taattatgaa aaatacattt tgagatttat ttctccatgg 940681 gcaatgatcg gatttcatta cactttattt gttattttta ttagtagagg ttatcaattt 940741 atccacgaaa ttggttctgc aatattgtgc tttgtcccat tggtgcttta cttctttatt 940801 gcatggtttt tgaccttcgc attaatgagg tacttatcaa tatctaggag tgatacacaa 940861 agagaatgta gctgtgacca agaactactt ttaaagaggg tctggggaag aaagtcttgt 940921 gaagctagct tttctattac gatgacgcaa tgtttcacta tggcttcaaa taattttgaa 940981 ctatccctgg caattgctat ttccttatat ggtaacaata gcaagcaagc aatagctgca 941041 acatttgggc cgttgctaga agttccaatt ttattgattt tggcaatagt cgcgaggatc 941101 cttaaaccat attatatatg gaacaataga aattaattgt tgactcacca aaaaattact 941161 tgggcaccaa tgaataatac cacttataac tctatattaa tccaagttca ccctaaaaac 941221 agataaaatt gacaattttt tttgaaggac aactgattga tcttagtgat ggttaggatg 941281 aaaaaatggg tttgttcacg ccatcccgca tcattcaaaa actccgcaca gttttggagt 941341 tcagtaagaa ggggacgtaa tcttactatt gcatttttga aagtctaatg aactcaagtg 941401 gcaaactgtg ttacgtacat cacttctaaa tacaatgtct ttgaattaga aactcgctga 941461 aaaattatta ttgcgtattg tatgtcattt ttgagatttt cctgcaagat tagtaatgct 941521 ttaaacccaa gtattgtaag cccgatggaa tagcacatgg tgatggtaca acaatggctt 941581 catagatcat tcgcataaaa atggaattcg tgcatctagt gtctaattaa aattaacgta 941641 acgaaatagg acaagataag cttatgtcgt agtacccgca taagtacgtg tagctgccat 941701 tttataatgc atgaagttga agtcattagg atgaagaggt gacatataat gtttcaaaat 941761 ggtgccagta taagtttggg atatcatgga gcggcattcg ttttagtaaa tgactgtatt 941821 gtatagtact gtctgtatga ttatcagttg agttggtgag atgaagtaaa gatattatag 941881 catctgcgtt aatgtgtatt gctattatag tatagcatag tggtgttata tagtggcacc 941941 gggaatgagt atagggagta agaagatctt gtagttgcgt ttgaatagcg acatgaggac 942001 acgtcttatg tcgccattat taggctgaaa ttgcaagcat aaactattcg atatcaaaga 942061 taccacaaga ccatgtatgc ataattatag aataccaagg tggggagaga ttaaaaacgc 942121 accatagcag ctgcgcgagt atattctgct attaaattgg aattcactga aaggtgatga 942181 gaatgcaaat agctatgata ccttatagtg gttaatttgt atgaaaacgt tataaagcat 942241 gaagttgaga gtattgatat gataatggag gttctgtgat caattttaga aaattaaaat 942301 gtggatgatc atgaatgtta tgggtaaatg gcacaagtaa tagacaattt aatgaatagg 942361 gtgttatgtt tacgatattt caattatgtt aatatttagt atgtttatat cttctcatta 942421 atgaatggtt aatttttatg tttaggtgat tttggtggtg attttgtggt tatattgaca 942481 taagtgtgta taaattgagt ggttagtata tggtgcagtt atacaatatt tggaaccgca 942541 aaatgagatg tagatattaa aatgtggata atcatgggct ttatgggtga atggcacagg 942601 gtatagaccg ctgaggcaag tgccgtgcat aatgatgtga gtgcatctag tactgattta 942661 gtgagaatgg ggccatggtg tggaatatga aagtagggta agtttgagat ggtatatact 942721 gtagcatccg tgtgcgtatg acatatcagt agaagtgaag gtgagtgtgg caagtggcgg 942781 tggtggtagt ggtggtatag agtggtaggc tcctttactt cgaagcgtga ggtcgtatac 942841 ctaataagga aatgtaattt ataacttttt attatattgg tcttttcgag agcggaagaa 942901 gttgtaggct aagcgcaggc taagcgtagg tccatgttta aagtatccaa gagaatatcc 942961 acgaagcggc tgagcaacga acagaatcct ggttctcctc gactaagcag atagttaaga 943021 tactgtgcac catggaaatt gaaaacgaac gtacgtaccg actactttat ttttgcaggc 943081 cggaaatcaa gcgatgaatg agacatcctt ctgttttcta tgttgtgctt gaaggggaca 943141 gacagtcgct tatcttagtg agattgctta ctaactgaat ttactttgct gctgctagag 943201 atttgcacct gcatagcgca gattctgcat cttctcaata gcttaattat tacattctca 943261 gatgatgata agacggaaac tggacaatct tttgtttata ttgatggatt tcttgtcaaa 943321 aagcataaca atcaacatac tattgttaat ttcgaaactt acaaaaataa aatgaaagtt 943381 tccgataggc gtaagtttga aaaagcaaac tttgacgagt ttgagtcggc tctaaataac 943441 aaaaacgact tggtacattg tccctcaata actttatttg aatcgatccc cacggaagtg 943501 cggtcattct acgaagacga aaagtctggc ctaatcaaag tggtaaaatt cagaactggt 943561 gcaatggata ggaaaaggtc ttttgaaaaa attgtcattt ccgtcatggt cgggaaaaat 943621 gtacaaaagt tcctgacatt tgttgaagac gaaccagatt tccagggcgg accaatccct 943681 tcaaagtatc ttattcccaa gaaaatcaac ttgatggtct acacgttgtt tcaagtgcat 943741 actttgaaat tcaatagaaa ggattacgat accctttctc ttttttacct caacagagga 943801 tactataatg agttgagttt tccgtgtcct ggaacgttgt cacgaaatag cgagtgccag 943861 gccgaacgac agctctacga tgcgtacttt cactgacttt gtttctggcg cacctattgt 943921 aaggagtctt cagaaaagca ccataaggaa atatgggtac aatttggcac cccacatgtt 943981 tttgttacta cacgtagatg agctatcgat tttttctgca taccaagcaa gtttacctgg 944041 cgaaaagaaa gtcgacacag agcggctgaa gcgtgatcta tgcccacgta aacccattga 944101 gataaagtac ttttcacaga tatgtaacga tatgatgaac aaaaaggacc gattgggtga 944161 tgttttgcat gtgtgctgcc caagttgaga agagatacta acaaaatgac cgcggctctc 944221 aaaaataatt gacgagctta cggtgatacg cttaccgtta tccagagcta cagcgcaacg 944281 tatacgtcga cgatacaaca agaacggttc atcggagcct cgactaaaga cgcttgacgg 944341 actcacttcc gagcgctgga ttcaatggtt aggccttgaa agcgactacc attgttcatt 944401 ctctagtact cggaatgcgg aagacgtagt ggcaggtgag gcggcgagtt cagatcatca 944461 tcaaaaaatt tcaagagtaa cgcgaaaaag gccccgagag cccaagagta caaacgatat 944521 cctcgtcgca ggccagaaac tctttggcag ctcctttgaa ttcagggact tgcatcagtt 944581 gcgcttatgt catgaaatat acatggcaga cacaccctct gtggcagtac aggccccacc 944641 gggctatggt aagacggagt tatttcatct ccccttgata gcactggcgt ctaagggcga 944701 cgtgaaatat gtgtcgtttc tgtttgtacc gtacacagtg ttgcttgcta attgcatgat 944761 caggttgggc cgatgcggtt gcttgaatgt ggcccctgta agaaacttta ttgaagaagg 944821 ttgcgatggc gttactgatt tatacgtggg gatctacgat gatcttgcta gcactaattt 944881 cacagacagg atagctgcgt gggagaatat tgttgagtgc acctttagga ccaacaacgt 944941 aaaattgggt tacctcattg tagatgagtt tcacaacttt gaaacggagg tctaccggca 945001 gtcgcaattt gggggcataa ctaaccttga ttttgacgct tttgagaaag caatcttttt 945061 gagcggcaca gcacctgagg ctgtagctga tgctgcgttg cagcgtattg ggcttacggg 945121 actggccaag aagtcgatgg acatcaacga gctcaaacgg tcggaagatc tcagcagagg 945181 tctatccagc tatccaacac ggatgtttaa tctaatcaag gagaaatccg aggtgccttt 945241 agggcatgtt cataaaattt ggaagaaagt ggaatcacag cccgaagaag cactgaagct 945301 tcttttagcc ctctttgaaa ttgaaccaga gtcgaaggcc attgtagttg caagcacaac 945361 caacgaagtg gaagaattgg cctgctcttg gagaaagtat tttagggtgg tatggataca 945421 cgggaagctg ggtgctgcag aaaaggtgtc tcgcacaaag gagtttgtca ctgacggtag 945481 catgcgagtt ctcatcggaa cgaaattagt gactgaagga attgacatta agcaattgat 945541 gatggtgatc atgcttgata atagacttaa tattattgag ctcattcaag gcgtagggag 945601 actaagagat gggggcctct gttatctatt atctagaaaa aacagttggg cggcaaggaa 945661 tcgtaagggt gaattaccac cgattaagga aggctgtata accgaacagg tacgcgagtt 945721 ctatggactt gaatcaaaga aaggaaaaaa gggccagcat gttggatgct gtggctccag 945781 gacagacctg tctgctgaca cagtggaact gatagaaaga atggacagat tggctgaaaa 945841 acaggcgaca gcttccatgt cgatcgttgc gttaccgtct agcttccagg agagcaatag 945901 cagtgacagg tgcagaaagt attgcagcag tgatgaggac agcaacacgt gcattcatgg 945961 tagtgctaat gccagtacca atgcgactac caactccagc actaatgcta ctaccactgc 946021 cagcaccaac gtcaggacta gtgctactac cactgccagc atcaacgtca ggactagtgc 946081 gactaccact gaaagtacca actccagcac taatgctact accactgcca gcaccaacgt 946141 caggactagt gctactacca ctgccagcat caacgtcagg actagtgcga ctaccactga 946201 aagtaccaac tccaacacta gtgctactac caccgaaagt accgactcca acactagtgc 946261 tactaccact gaaagtacca actccagcac taatgctact accactgcca gcatcaacgt 946321 caggactagt gcgactacca ctgaaagtac caactccaac actaatgcta ctaccactga 946381 aagtaccaac tccagcacta atgctactac cactgaaggt accaactcca acactagtgc 946441 tactaccact gctagcacca actccagcac taatgctact accactgaaa gtaccaacgc 946501 tagtgccaag gaggacgcca ataaagatgg caatgctgag gataatagat tccatccagt 946561 caccgacatt aacaaagagt cgtataagcg gaaagggagt caaatggttt tgctagagag 946621 aaagaaactg aaagcacaat ttcccaatac ttccgagaat atgaatgtct tacagtttct 946681 tggatttcgg tctgacgaaa ttaaacatct tttcctctat ggtattgacg tatacttctg 946741 cccagaggga gtattcacac aatacggatt atgcaagggc tgtcaaaaga tgttcgagct 946801 ctgtgtctgt tgggctggcc agaaagtatc gtatcggagg atggcttggg aagcactagc 946861 tgtggagaga atgctgcgaa atgacgagga atacaaagaa tacttggaag acatcgagcc 946921 atatcatggg gaccctgtag gatatttgaa atattttagc gtaaaaaggg gagagatcta 946981 ctctcagata cagagaaatt atgcttggta cctggccatt actagaagaa gagaaacaat 947041 tagtgtattg gattcgacaa gaggcaagca agggagccaa gttttccgca tgtctggaag 947101 gcagatcaaa gagttgtatt ataaagtatg gagcaacttg cgtgaatcga agacagaggt 947161 gctgcagtac tttttgaact gggacgaaaa aaagtgccgg gaagaatggg aggcaaaaga 947221 cgatacggtc tttgtggaag cgctcgagaa agttggagtt tttcagcgtt tgcgttccat 947281 gacgagcgct ggactgcagg gtccgcagta cgtcaagctg cagtttagca ggcatcatcg 947341 acagttgagg agcagatatg aattaagtct aggaatgcac ttgcgagatc agcttgcgct 947401 gggagttacc ccatctaaag tgccgcattg gacggcattc ctgtcgatgc tgatagggct 947461 gttctgcaat aaaacatttc ggcagaaact ggaatatctt ttggagcaga tttcggaggt 947521 gtggttgtta ccacattggc ttgatttggc aaacgttgaa gttctcgctg cagataacac 947581 gagggtaccg ctgtacatgc tgatggtagc ggttcacaaa gagctggata gcgatgatgt 947641 tccagacggt agatttgata tattattatg tagagattcg agcagagaag ttggagagtg 947701 aaggaaattg ttgttacgaa agtcagtgat tatgtattgt gtagtatagt atattgtaag 947761 aaattttttt ttctagggaa tatgcgtttt gatgtagtag tatttcactg ttttgattta 947821 gtgtttgttg cacggcagta gcgagagaca agtgggaaag agtaggataa aaagacaatc 947881 tataaaaagt aaacataaaa taaaggtagt aagtagcttt tggttgaaca tccgggtaag 947941 agacaacagg gcttggagga gacgtacatg agggctattt agggctattt agggctatgt 948001 agaagtgttg tagggctaaa gaacagggtt tcattttcat tttttttttt taatttcggt 948061 cagaaa //