LOCUS BK006947 784333 bp DNA linear PLN 30-JUN-2025 DEFINITION TPA_inf: Saccharomyces cerevisiae S288C chromosome XIV, complete sequence. ACCESSION BK006947 VERSION BK006947.3 DBLINK BioProject: PRJNA43747 KEYWORDS Third Party Data; TPA; TPA:inferential. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. REFERENCE 1 (bases 1 to 784333) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 2 (bases 1 to 784333) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (bases 1 to 784333) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 4 (bases 1 to 784333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REFERENCE 5 (bases 1 to 784333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (bases 1 to 784333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (bases 1 to 784333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter COMMENT THIRD PARTY DATABASE: This TPA record uses data from DDBJ/EMBL/GenBank entries Z71277.1, Z71278.1, Z71279.1, Z71280.1, Z71281.1, Z71282.1, Z71283.1, Z71284.1, Z71285.1, Z71286.1, Z71287.1, Z71288.1, Z71290.1, Z71291.1, Z71292.1, Z71293.1, Z71294.1, Z71295.1, Z71296.1, Z71297.1, Z71298.1, Z71299.1, Z71300.1, Z71301.1, Z71302.1, Z71303.1, Z71305.1, Z71306.1, Z71307.1, Z71308.1, Z71309.1, Z71310.1, Z71311.1, Z71312.1, Z71313.1, Z71314.1, Z71315.1, Z71316.1, Z71317.1, Z71318.1, Z71320.1, Z71321.1, Z71322.1, Z71323.1, Z71324.1, Z71325.1, Z71326.1, Z71327.1, Z71328.1, Z71329.1, Z71330.1, Z71331.1, Z71332.1, Z71334.1, Z71335.1, Z71337.1, Z71338.1, Z71339.1, Z71340.1, Z71341.1, Z71342.1, Z71343.1, Z71344.1, Z71345.1, Z71346.1, Z71347.1, Z71348.1, Z71349.1, Z71350.1, Z71351.1, Z71352.1, Z71353.1, Z71354.1, Z71355.1, Z71356.1, Z71357.1, Z71359.1, Z71360.1, Z71361.1, Z71362.1, Z71363.1, Z71364.1, Z71366.1, Z71367.1, Z71368.1, Z71369.1, Z71370.1, Z71371.1, Z71372.1, Z71373.1, Z71374.1, Z71375.1, Z71376.1, Z71377.1, Z71378.1, Z71379.1, Z71380.1, Z71382.1, Z71383.1, Z71385.1, Z71386.1, Z71387.1, Z71388.1, Z71390.1, Z71391.1, Z71392.1, Z71393.1, Z71394.1, Z71396.1, Z71397.1, Z71398.1, Z71399.1, Z71400.1, Z71401.1, Z71402.1, Z71403.1, Z71404.1, Z71405.1, Z71406.1, Z71407.1, Z71408.1, Z71409.1, Z71410.1, Z71411.1, Z71412.1, Z71413.1, Z71414.1, Z71416.1, Z71417.1, Z71418.1, Z71419.1, Z71420.1, Z71421.1, Z71422.1, Z71423.1, Z71424.1, Z71426.1, Z71427.1, Z71428.1, Z71429.1, Z71430.1, Z71431.1, Z71432.1, Z71433.1, Z71434.1, Z71435.1, Z71436.1, Z71437.1, Z71438.1, Z71439.1, Z71440.1, Z71441.1, Z71442.1, Z71443.1, Z71444.1, Z71448.1, Z71449.1, Z71451.1, Z71452.1, Z71453.1, Z71454.1, Z71455.1, Z71456.1, Z71457.1, Z71458.1, Z71459.1, Z71461.1, Z71462.1, Z71463.1, Z71464.1, Z71465.1, Z71466.1, Z71467.1, Z71468.1, Z71469.1, Z71470.1, Z71471.1, Z71472.1, Z71473.1, Z71475.1, Z71476.1, Z71477.1, Z71479.1, Z71482.1, Z71483.1, Z71484.1, Z71485.1, Z71486.1, Z71487.1, Z71488.1, Z71489.1, Z71490.1, Z71491.1, Z71492.1, Z71493.1, Z71494.1, Z71495.1, Z71496.1, Z71497.1, Z71498.1, Z71499.1, Z71500.1, Z71501.1, Z71504.1, Z71505.1, Z71506.1, Z71507.1, Z71508.1, Z71509.1, Z71510.1, Z71512.1, Z71513.1, Z71514.1, Z71515.1, Z71516.1, Z71517.1, Z71518.1, Z71519.1, Z71520.1, Z71522.1, Z71523.1, Z71524.1, Z71525.1, Z71526.1, Z71527.1, Z71528.1, Z71529.1, Z71530.1, Z71531.1, Z71532.1, Z71533.1, Z71534.1, Z71535.1, Z71536.1, Z71537.1, Z71538.1, Z71539.1, Z71540.1, Z71542.1, Z71543.1, Z71544.1, Z71545.1, Z71546.1, Z71547.1, Z71548.1, Z71549.1, Z71550.1, Z71551.1, Z71553.1, Z71554.1, Z71555.1, Z71556.1, Z71557.1, Z71558.1, Z71559.1, Z71560.1, Z71561.1, Z71562.1, Z71563.1, Z71564.1, Z71565.1, Z71566.1, Z71567.1, Z71568.1, Z71569.1, Z71570.1, Z71571.1, Z71573.1, Z71574.1, Z71575.1, Z71576.1, Z71577.1, Z71578.1, Z71580.1, Z71581.1, Z71582.1, Z71583.1, Z71584.1, Z71585.1, Z71586.1, Z71587.1, Z71588.1, Z71589.1, Z71590.1, Z71591.1, Z71592.1, Z71593.1, Z71595.1, Z71596.1, Z71597.1, Z71598.1, Z71599.1, Z71601.1, Z71602.1, Z71603.1, Z71604.1, Z71605.1, Z71606.1, Z71607.1, Z71608.1, Z71609.1, Z71610.1, Z71611.1, Z71612.1, Z71613.1, Z71614.1, Z71615.1, Z71616.1, Z71617.1, Z71618.1, Z71619.1, Z71620.1, Z71622.1, Z71623.1, Z71624.1, Z71625.1, Z71626.1, Z71627.1, Z71628.1, Z71629.1, Z71630.1, Z71631.1, Z71632.1, Z71633.1, Z71634.1, Z71635.1, Z71636.1, Z71637.1, Z71638.1, Z71639.1, Z71641.1, Z71642.1, Z71643.1, Z71644.1, Z71645.1, Z71646.1, Z71647.1, Z71648.1, Z71649.1, Z71650.1, Z71651.1, Z71652.1, Z71653.1, Z71654.1, Z71655.1, Z71656.1, Z71658.1, Z71659.1, Z71660.1, Z71661.1, Z71662.1, Z71663.1, Z71664.1, Z71665.1, Z71666.1, Z71667.1, Z71668.1, Z71669.1, Z71670.1, Z71671.1, Z71672.1, Z71673.1, Z71674.1, Z71675.1, Z71676.1, Z71677.1, Z71678.1, Z71679.1, Z71680.1, Z71681.1, Z71682.1, Z71683.1, Z71684.1, Z71686.1, Z71687.1, Z71688.1, Z71689.1, Z71690.1, Z71691.1 and Z71692.1 On Apr 18, 2011 this sequence version replaced BK006947.2. ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..784333 /organism="Saccharomyces cerevisiae S288C" /mol_type="genomic DNA" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" telomere complement(1..7428) /note="TEL14L; Telomeric region on the left arm of Chromosome XIV; composed of an X element core sequence, X element combinatorial repeats, a short stretch of telomeric repeats, and a long Y' element" /db_xref="SGD:S000028924" gene complement(371..6098) /gene="YRF1-6" /locus_tag="YNL339C" /gene_synonym="YRF1" mRNA complement(join(371..5931,6080..6098)) /gene="YRF1-6" /locus_tag="YNL339C" /gene_synonym="YRF1" /product="Y' element ATP-dependent helicase protein 1 copy 6" CDS complement(join(371..5931,6080..6098)) /gene="YRF1-6" /locus_tag="YNL339C" /gene_synonym="YRF1" /EC_number="3.6.4.12" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9837911]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:9837911]" /note="Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p" /codon_start=1 /product="Y' element ATP-dependent helicase protein 1 copy 6" /protein_id="DAA10226.1" /db_xref="SGD:S000005283" /translation="MEIENEQICTCIAQILHLLNSLIITFLDDDKTETGQSFVYIDGF LVKKHNNQHTIVNFETYKNKMKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFES IPTEVRSFYEDEKSGLIKVVKFRTGAMDRKRSFEKIVVSVMVGKNVQKFLTFVEDEPD FQGGPIPSKYLIPKKINLMVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLE RCYEIASARPNDSSTMRTFTDFVSGTPIVRGLQKSTIRKYGYNLAPYMFLLLHVDELS IFSAYQASLPGEKKVDTERLKRDLCPRKPTEIKYFSQICNDMMNKKDRLGDILHIILR ACALNFGAGPRGGAGDEEDRSITNEEPIIPSVDEHGLKVCKLRSPNTPRRLRKTLDAV KALLVSSCACTARDLDIFDDNNGVAMWKWIKILYHEVAQETALKDSYRITLVPSSDGV SVCGKLFNREYVRGFYFACKAQFDNLWEELNDCFYMPTVVDIASLILRNREVLFREPK RGIDEYLENDSFLQMIPVKYREIVLPKLRRDTNKMTAALKNKVTVAIDELTVPLMWMI HFAVGYPYRYPELQLLAFAGPQRNVYVDDTTRRIQLYTDYNKNGSSEPRLKTLDGLTS DYVFYFVTVLRQMQICALGNSYDAFNHDPWMDVVGFEDPDQVTNRDISRIVLYSYMFL NTAKGCLVEYATFRQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESAT SELMANHSVQTGRNIYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSS TRNAEDVVAGEAASSDHHQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQL RLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANC MIRLSRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFR TNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQ RIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVES QPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVS RTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCY LLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSAD TVELIERMDRLAEKQATASMSIVALPSSFQESNSSDRCRKYCSSDEDSDTCIHGSANA STNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTTASTNVRT SATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSNTSATTTASTNS STNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQ MVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDVYFCPEGVFTQYGLCK GCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLK FFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYK VWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQ GPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFCNK TFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPD GRFDILLCRDSSREVGE" gene 8330..9475 /gene="COS1" /locus_tag="YNL336W" mRNA 8330..9475 /gene="COS1" /locus_tag="YNL336W" /product="Cos1p" CDS 8330..9475 /gene="COS1" /locus_tag="YNL336W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:25942624]" /note="Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins" /codon_start=1 /product="Cos1p" /protein_id="DAA10227.1" /db_xref="SGD:S000005280" /translation="MKENELKNEKSVDVLSFKQLESQKIVLPQDLFRSSFTWFCYEIY KSLAFRIWMLLWLPLSVWWKLSNNCIYPLIVSLLVLFLGPIFVLVICGLSRKRSLSKQ LIQFCKEVTENTPSSDPHDWEVVAANLNSYLYENKAWNTKYFFFNAMVCQEAFRTTLL EPFSLKKDEAAKVKSFKDSVPYIEEALGVYFREVEKQWKLFNSEKSWSPVGLEDAKLP KEAYRFKLTWFLKRISNIFMLIPFLNFLCCIYVSRGMCLLLRTFYLGWILFMLVQGFQ NMRMIVLSVKMEHKMQFLSTIINEQESGANGWDEIAKKMNRYLFEKKVWKNEEFFFDG IDCEWFFSHFFYRVLSAKKSMRALSLNVELWPYIKEAQLSCSEESLA" gene 11452..12129 /gene="DDI2" /locus_tag="YNL335W" /gene_synonym="DDI3" mRNA 11452..12129 /gene="DDI2" /locus_tag="YNL335W" /gene_synonym="DDI3" /product="cyanamide hydratase" CDS 11452..12129 /gene="DDI2" /locus_tag="YNL335W" /gene_synonym="DDI3" /EC_number="4.2.1.69" /experiment="EXISTENCE:direct assay:GO:0018820 cyanamide hydratase activity [PMID:25847245]" /experiment="EXISTENCE:mutant phenotype:GO:0018890 cyanamide metabolic process [PMID:25847245]" /note="Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI3 and Ddi3p" /codon_start=1 /product="cyanamide hydratase" /protein_id="DAA10228.1" /db_xref="SGD:S000005279" /translation="MSQYGFVRVPREVEKAIPVVNAPRPRAVVPPPNSETARLVREYA AKELTAPVLNHSLRVFQYSVAIIRDQFPAWDLDQEVLYVTCLLHDIATTDKNMRATKM SFEYYGGILSRELVFNATGGNQDYADAVTEAIIRHQDLTGTGYITTLGLILQIATTLD NVGSNTDLIHIDTVSAINEQFPRLHWLSCFATVVDTENSRKPWGHTSSLGDDFSKKVI CNTFGYN" gene complement(12208..12876) /gene="SNO2" /locus_tag="YNL334C" mRNA complement(12208..12876) /gene="SNO2" /locus_tag="YNL334C" /product="putative pyridoxal 5'-phosphate synthase" CDS complement(12208..12876) /gene="SNO2" /locus_tag="YNL334C" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /note="hypothetical protein; nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin" /codon_start=1 /product="putative pyridoxal 5'-phosphate synthase" /protein_id="DAA10229.1" /db_xref="SGD:S000005278" /translation="MTVVIGVLALQGAFIEHVRHVEKCIVENRDFYEKKLSVMTVKDK NQLAQCDALIIPGGESTAMSLIAERTGFYDDLYAFVHNPSKVTWGTCAGMIYISQQLS NEEKLVKTLNLLKVKVKRNAFGRQAQSSTRICDFSNFIPHCNDFPATFIRAPVIEEVL DPEHVQVLYKLDGKDNGGQELIVAAKQKNNILATSFHPELAENDIRFHDWFIREFVLK NYSK" gene 13267..14163 /gene="SNZ2" /locus_tag="YNL333W" mRNA 13267..14163 /gene="SNZ2" /locus_tag="YNL333W" /product="pyridoxine biosynthesis protein SNZ2" CDS 13267..14163 /gene="SNZ2" /locus_tag="YNL333W" /EC_number="4.3.3.6" /experiment="EXISTENCE:genetic interaction:GO:0008615 pyridoxine biosynthetic process [PMID:30498136]" /experiment="EXISTENCE:genetic interaction:GO:0009228 thiamine biosynthetic process [PMID:30498136]" /experiment="EXISTENCE:genetic interaction:GO:0042819 vitamin B6 biosynthetic process [PMID:12271461]" /note="Protein involved in thiamine and pyridoxine biosynthesis; member of a stationary phase-induced gene family where transcriptional induction precedes the diauxic shift; induced in the absence of thiamin in a Thi2/3p-dependent manner and repressed in its presence; forms a co-regulated gene pair with SNO2; interacts with Thi11p; paralog of SNZ1 and SNZ3" /codon_start=1 /product="pyridoxine biosynthesis protein SNZ2" /protein_id="DAA10230.1" /db_xref="SGD:S000005277" /translation="MSEFKVKTGLAQMLKGGVIMDVVTPEQAIIAERAGACAVMALER IPADMRKSGQVCRMSDPRMIKEIMEAVSIPVMAKVRIGHFVEAQILEELQVDYIDESE VLTPADWTHHIEKHNFKVPFVCGAKDLGEALRRINEGAAMIRTKGEAGTGDVSEAVKH ITKIKAEIQQYKENLKTESDFAAKATELRVPVDLLKTTLSEGKLPVVNFAAGGVATPA DAALLMQLGCEGVFVGSGIFKSSDPEKLACAIVEATTHYDNPAKLLQISSDLGDLMGG ISIQSINEAGGKNGARLSEIGW" gene 14832..15854 /gene="THI12" /locus_tag="YNL332W" mRNA 14832..15854 /gene="THI12" /locus_tag="YNL332W" /product="4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase" CDS 14832..15854 /gene="THI12" /locus_tag="YNL332W" /experiment="EXISTENCE:genetic interaction:GO:0009228 thiamine biosynthetic process [PMID:12777485]" /note="Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP" /codon_start=1 /product="4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase" /protein_id="DAA10231.1" /db_xref="SGD:S000005276" /translation="MSTDKITFLLNWQPTPYHIPIFLAQTKGYFKEQGLDMAILEPTN PSDVTELIGSGKVDMGLKAMIHTLAAKARGFPVTSVASLLDEPFTGVLYLKGSGITED FQSLKGKKIGYVGEFGKIQIDELTKHYGMKPEDYTAVRCGMNVAKYIIEGKIDAGIGI ECMQQVELEEYLAKQGRPASDAKMLRIDKLACLGCCCFCTVLYICNDEFLKKNPEKVR KFLKAIKKATDYVLADPVKAWKEYIDFKPRLNNDLSYKQYQRCYAYFSSSLYNVHRDW KKVTGYGKRLAILPPDYVSNYTNEYLSWPEPEEVSDPLEAQRLMAIHQEKCRQEGTFK RLALPA" gene complement(16118..17248) /gene="AAD14" /locus_tag="YNL331C" mRNA complement(16118..17248) /gene="AAD14" /locus_tag="YNL331C" /product="putative aryl-alcohol dehydrogenase" CDS complement(16118..17248) /gene="AAD14" /locus_tag="YNL331C" /experiment="EXISTENCE:direct assay:GO:0047681 aryl-alcohol dehydrogenase (NADP+) activity [PMID:29079624]" /note="Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" /codon_start=1 /product="putative aryl-alcohol dehydrogenase" /protein_id="DAA10232.1" /db_xref="SGD:S000005275" /translation="MTDLFKPLPEPPTELGRLRVLSKTAGIRVSPLILGGASIGDAWS GFMGSMNKEQAFELLDAFYEAGGNCIDTANSYQNEESEIWIGEWMASRKLRDQIVIAT KFTGDYKKYEVGGGKSANYCGNHKRSLHVSVRDSLRKLQTDWIDILYIHWWDYMSSIE EVMDSLHILVQQGKVLYLGVSDTPAWVVSAANYYATSHGKTPFSVYQGKWNVLNRDFE RDIIPMARHFGMALAPWDVMGGGRFQSKKAMEERKKNGEGLRTFVGGPEQTELEVKIS EALTKIAEEHGTESVTAIAIAYVRSKAKNVFPLIGGRKIEHLKQNIEALSIKLTPEQI EYLESIVPFDVGFPKSLIGDDPAVTKKLSPLTSMSARIAFDN" gene complement(18001..19302) /gene="RPD3" /locus_tag="YNL330C" /gene_synonym="MOF6" /gene_synonym="REC3" /gene_synonym="SDI2" /gene_synonym="SDS6" mRNA complement(18001..19302) /gene="RPD3" /locus_tag="YNL330C" /gene_synonym="MOF6" /gene_synonym="REC3" /gene_synonym="SDI2" /gene_synonym="SDS6" /product="histone deacetylase RPD3" CDS complement(18001..19302) /gene="RPD3" /locus_tag="YNL330C" /gene_synonym="MOF6" /gene_synonym="REC3" /gene_synonym="SDI2" /gene_synonym="SDS6" /EC_number="3.5.1.98" /experiment="EXISTENCE:direct assay:GO:0000118 histone deacetylase complex [PMID:8962081]" /experiment="EXISTENCE:direct assay:GO:0004407 histone deacetylase activity [PMID:12110674]" /experiment="EXISTENCE:direct assay:GO:0032221 Rpd3S complex [PMID:16286008|PMID:16286007]" /experiment="EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:16286007|PMID:16314178|PMID:19040720|PMID:16286008]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:direct assay:GO:0070211 Snt2C complex [PMID:19040720]" /experiment="EXISTENCE:direct assay:GO:0070822 Sin3-type complex [PMID:9234741]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:19823668]" /experiment="EXISTENCE:genetic interaction:GO:0000086 G2/M transition of mitotic cell cycle [PMID:17908798]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11069890]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19823668|PMID:17908798]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:19948887]" /experiment="EXISTENCE:genetic interaction:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:15143171]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17210643|PMID:17296735]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:20398213|PMID:17121596|PMID:24358376|PMID:15141165|P MID:16314178|PMID:24881874|PMID:17158929]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:14737171]" /experiment="EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:9150136]" /experiment="EXISTENCE:mutant phenotype:GO:0004407 histone deacetylase activity [PMID:12110674|PMID:8962081|PMID:9572144|PMID:9512514]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:24881874]" /experiment="EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:22539722]" /experiment="EXISTENCE:mutant phenotype:GO:0016479 negative regulation of transcription by RNA polymerase I [PMID:14609951|PMID:19270272]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:12453428|PMID:15143171|PMID:19417103]" /experiment="EXISTENCE:mutant phenotype:GO:0034503 protein localization to nucleolar rDNA repeats [PMID:17203076]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:20398213]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:31553911]" /experiment="EXISTENCE:mutant phenotype:GO:0045128 negative regulation of reciprocal meiotic recombination [PMID:18515193]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20398213|PMID:17210643|PMID:17296735|PMID:17706600|P MID:15254041]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:17158929]" /experiment="EXISTENCE:mutant phenotype:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:10512855|PMID:10388812|PMID:19372273]" /experiment="EXISTENCE:mutant phenotype:GO:0061188 negative regulation of rDNA heterochromatin formation [PMID:10512855|PMID:10388812|PMID:10082585]" /experiment="EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:35477092|PMID:31553911]" /experiment="EXISTENCE:physical interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:19823668]" /experiment="EXISTENCE:physical interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11069890]" /experiment="EXISTENCE:physical interaction:GO:0003713 transcription coactivator activity [PMID:14737171]" /experiment="EXISTENCE:physical interaction:GO:0003714 transcription corepressor activity [PMID:9150136]" /experiment="EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19823668]" /note="Histone deacetylase, component of both Rpd3S and Rpd3L complexes; regulates transcription, silencing, autophagy and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; Rpd3(L) recruitment to the subtelomeric region is regulated by interaction with the Hmt1p methyltransferase; delays late firing of single copy origins by opposing the Fkh1/2 origin activation pathway" /codon_start=1 /product="histone deacetylase RPD3" /protein_id="DAA10233.1" /db_xref="SGD:S000005274" /translation="MVYEATPFDPITVKPSDKRRVAYFYDADVGNYAYGAGHPMKPHR IRMAHSLIMNYGLYKKMEIYRAKPATKQEMCQFHTDEYIDFLSRVTPDNLEMFKRESV KFNVGDDCPVFDGLYEYCSISGGGSMEGAARLNRGKCDVAVNYAGGLHHAKKSEASGF CYLNDIVLGIIELLRYHPRVLYIDIDVHHGDGVEEAFYTTDRVMTCSFHKYGEFFPGT GELRDIGVGAGKNYAVNVPLRDGIDDATYRSVFEPVIKKIMEWYQPSAVVLQCGGDSL SGDRLGCFNLSMEGHANCVNYVKSFGIPMMVVGGGGYTMRNVARTWCFETGLLNNVVL DKDLPYNEYYEYYGPDYKLSVRPSNMFNVNTPEYLDKVMTNIFANLENTKYAPSVQLN HTPRDAEDLGDVEEDSAEAKDTKGGSQYARDLHVEHDNEFY" gene complement(19541..22633) /gene="PEX6" /locus_tag="YNL329C" /gene_synonym="PAS8" mRNA complement(19541..22633) /gene="PEX6" /locus_tag="YNL329C" /gene_synonym="PAS8" /product="AAA family ATPase peroxin 6" CDS complement(19541..22633) /gene="PEX6" /locus_tag="YNL329C" /gene_synonym="PAS8" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:12808025]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12808025]" /experiment="EXISTENCE:direct assay:GO:0016558 protein import into peroxisome matrix [PMID:29321502]" /experiment="EXISTENCE:direct assay:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078]" /experiment="EXISTENCE:direct assay:GO:0043335 protein unfolding [PMID:29321502]" /experiment="EXISTENCE:direct assay:GO:1904949 ATPase complex [PMID:16007078]" /experiment="EXISTENCE:direct assay:GO:1990351 transporter complex [PMID:16007078]" /experiment="EXISTENCE:genetic interaction:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078]" /experiment="EXISTENCE:mutant phenotype:GO:0005777 peroxisome [PMID:12808025]" /experiment="EXISTENCE:mutant phenotype:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:15634331]" /note="AAA-peroxin; heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; mutations in human PEX6 can lead to severe peroxisomal disorders and early death" /codon_start=1 /product="AAA family ATPase peroxin 6" /protein_id="DAA10234.1" /db_xref="SGD:S000005273" /translation="MKASLTFSLSGIYAPCSISRDIYLEYGDKKAECLYGTIRLPQYG PGCTPGKIVHCVLDDSLPFCSIVVPSKLFGFMPTQPTMDFCYFEPILDNVVPVLDSVT FLINEQLYSKLMDLPQEMQQIQFLHYKYNINSMETVVHSRDILTSGLCQILNCSPFPQ GLVDFTETQLILVNDTEQKLSALKYANEDEEYALPKIGTNSALSIDLESLPCTISRDL LRPAPHINDDNSIYAFTDAETLLRLDVTSGSFITVSNMGCVRLVKLFVLLLPNGFKKR TIYAPPKIIASFPDCSVVTISKSNIGHTDIPIANQVFISRVGGWLQSQKCFQNIILTT LKKFFSESKRILCQNDLIPIAFDSSMADLNIAEENDESDDEDELGQYYKNDSLVWFFV TSAELDCFSKDNSHFIIDPNRTKLITTNITNRRPLPLSRSNLQRYYGFAETFYYDLHI FPYVRQLVNILETSFNCSQRGITLNASVLLHSTTNNVGKATMVRFASKYLGIHLLEID CLSLTSNSRQLDSTSKIIGYIRAKCENVLPYASPAVIFLAHLDSILLDVNANQDPEAI KLQKSINFEMSKLLDDFTFKFPGTTFVGSVNNIDNVPSSFRSHMRFEILVPVPSEAQR LRIFQWYLSSHELNRDVQQKVPVSYMDNISFSSLSSYSAGLTPLDIKSIVETARMTAT ARFYQESKKCGWLPQSILITQEDLSKATSKARNEFSVSIGAPQIPNVTWDDIGGIDFV KGEILDTIDMPLKHPELFTSGMKKRSGILFYGPPGTGKTLMAKAIATNFSLNFFSVKG PELLNMYIGESEANVRRVFQKAREAKPCVIFFDEIDSVAPKRGNQGDSGGVMDRIVSQ LLAELDGMSTDADGVFVIGATNRPDLLDEALLRPGRFDKLLYLGIPDTDTKQLNILEA LTRKFVLDNDVKLIELAKLCPFNYTGADFYALCSDAMLNAMSRIARMVEKKVSQHNEL TGENISTRRWFDKIATKEDTKVVVKMEDFLKAQEQLTPSVSRAELNHYEAVRANFEGA " gene complement(22834..23274) /gene="MDJ2" /locus_tag="YNL328C" mRNA complement(22834..23274) /gene="MDJ2" /locus_tag="YNL328C" /product="Mdj2p" CDS complement(22834..23274) /gene="MDJ2" /locus_tag="YNL328C" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:16027163]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:9325105]" /experiment="EXISTENCE:genetic interaction:GO:0030150 protein import into mitochondrial matrix [PMID:16027163]" /experiment="EXISTENCE:physical interaction:GO:0001405 PAM complex, Tim23 associated import motor [PMID:16027163]" /experiment="EXISTENCE:physical interaction:GO:0030150 protein import into mitochondrial matrix [PMID:16027163]" /note="Constituent of the mitochondrial import motor; associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain" /codon_start=1 /product="Mdj2p" /protein_id="DAA10235.1" /db_xref="SGD:S000005272" /translation="MVLPIIIGLGVTMVALSVKSGLNAWTVYKTLSPLTIAKLNNIRI ENPTAGYRDALKFKSSLIDEELKNRLNQYQGGFAPRMTEPEALLILDISAREINHLDE KLLKKKHRKAMVRNHPDRGGSPYMAAKINEAKEVLERSVLLRKR" gene 24048..27173 /gene="EGT2" /locus_tag="YNL327W" mRNA 24048..27173 /gene="EGT2" /locus_tag="YNL327W" /product="Egt2p" CDS 24048..27173 /gene="EGT2" /locus_tag="YNL327W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:27229769]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:13679573]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:direct assay:GO:0030428 cell septum [PMID:15452134]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:8668141]" /note="Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase; localizes in birth scars; required for proper cell separation after cytokinesis; expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner" /codon_start=1 /product="Egt2p" /protein_id="DAA10236.2" /db_xref="SGD:S000005271" /translation="MNKLLLHLVRVISILGLANALTQTQPILKDIQITDSYTKTKECT DPDHWFIIEGQLSIPKGSQQNITFQVPDAFSSFPQEPFSIKHNSNSVATISRPDKSTN NFTISIPEKSSEDITTTFNFLAQLTSDAKSKVTEPKSIVYSFYSENTMFNDVIDYVAK NTSAITTDGGIYKTNNTAWFTVDLPMRTFRNPVYLTSQTSSSSDYVFDTSLTKFEVVT AVDSFNEPINAIPYTTVHDYSTEDEIRCLFNSTISGGLYFRVTYFTKKLSTSSISNTV ELTYPDEGTSVRLLGKRDTSTTLASELYSESAANIDSTTSDDTTSSDAAITPTYSNST LSSYTSQSSAIPEVAVTASLSSGILSSTVDGASTSADASMSAVSTVSSSSEQASSSSI SLSAPSSSNSTFTTPSSSLSATETYSIISSASISVTQASYIDNSTTTAVTQSTSTIAV SSAEKLSSTLSYTSNVTISVSSATQHTTTPSYVSNSTTLSSSSVLESVISSPYLANTT VSGASSASQSTNPPYVSNSTTSSATQLATIAPFAINITGTSISSSITNTSSVSSTTSS LSSGPFVSNTTVASGSYILTTTTESAQLTEIGSLIPISTITTSTTTSGTDKTGSNKVA SSTEIAQSIVNNSSLSVSTINTNAATAAANARNATFTHATHSGSLQPSYHSSSLLSST IDTKVTTATTSTSRDGSSSLAFTTGLNQSVVTGTDKSDTYSVISSTESAQVTEYDSLL PISTLKPTVVTGTSRNSTFSMVSSTKLTEATATDKGDAYSVISSTQSAQVTEYGSMLP ISTLETPTVIMSTDESGYFTLTTCTESGQATEYGSLIPISTLDGSVIYTFTGESVVVG YSTTVGAAQYAQHTSLVPVSTIKGSKTSLSTEESVVAGYSTTVGAAQYAQHTSLVPVS TIKGSKTSLSTEESVVAGYSTTVDSAQYAEHTNLVAIDTLKTSTFQKATATEVCVTCT ALSSPHSATLDAGTTISLPTSSSTSLSTIITWYSSSTIKPPSISTYSGAAGQLTIRIG SLLLGLISFLL" gene complement(27337..28347) /gene="PFA3" /locus_tag="YNL326C" mRNA complement(27337..28347) /gene="PFA3" /locus_tag="YNL326C" /product="palmitoyltransferase PFA3" CDS complement(27337..28347) /gene="PFA3" /locus_tag="YNL326C" /EC_number="2.3.1.225" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762|PMID:14562095|PMID:16301533]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:16186255]" /experiment="EXISTENCE:direct assay:GO:0016409 palmitoyltransferase activity [PMID:16186255]" /experiment="EXISTENCE:direct assay:GO:0018345 protein palmitoylation [PMID:16186255]" /experiment="EXISTENCE:mutant phenotype:GO:0000324 fungal-type vacuole [PMID:16301533]" /experiment="EXISTENCE:mutant phenotype:GO:0016409 palmitoyltransferase activity [PMID:26224664]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:16186255|PMID:16301533]" /note="Palmitoyltransferase for Vac8p; required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions" /codon_start=1 /product="palmitoyltransferase PFA3" /protein_id="DAA10237.1" /db_xref="SGD:S000005270" /translation="MNDRLSLTSLFPRCLTTCLYIWTAYITLTRIHQIPRWFLALTIV PTLAVALYTYYKVIARGPGSPLDFPDLLVHDLKAAENGLELPPEYMSKRCLTLKHDGR FRVCQVCHVWKPDRCHHCSSCDVCILKMDHHCPWFAECTGFRNQKFFIQFLMYTTLYA FLVLIYTCYELGTWFNSGSFNRELIDFHLLGVALLAVAVFISVLAFTCFSIYQVCKNQ TTIEVHGMRRYRRDLEILNDSYGTNEHLENIFDLGSSMANWQDIMGTSWLEWILPIET FKYKKSKHTKDEKGLYFNVRPQVQDRLLSSRCLEDQLLRRVTPRPSLEADRASVEIID AN" rep_origin 28469..28700 /note="ARS1405; Autonomously Replicating Sequence" /db_xref="SGD:S000118382" gene complement(28739..31378) /gene="FIG4" /locus_tag="YNL325C" mRNA complement(28739..31378) /gene="FIG4" /locus_tag="YNL325C" /product="phosphatidylinositol-3,5-bisphosphate 5-phosphatase" CDS complement(28739..31378) /gene="FIG4" /locus_tag="YNL325C" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14528018]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:direct assay:GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [PMID:14528018]" /experiment="EXISTENCE:direct assay:GO:0046856 phosphatidylinositol dephosphorylation [PMID:14528018]" /experiment="EXISTENCE:direct assay:GO:0070772 PAS complex [PMID:19037259]" /experiment="EXISTENCE:genetic interaction:GO:0046856 phosphatidylinositol dephosphorylation [PMID:11950935]" /experiment="EXISTENCE:physical interaction:GO:0070772 PAS complex [PMID:19037259]" /note="Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain; homologous to human FIG4, which is associated with CMT4J, a form of Charcot-Marie-Tooth disorder" /codon_start=1 /product="phosphatidylinositol-3,5-bisphosphate 5-phosphatase" /protein_id="DAA10238.1" /db_xref="SGD:S000005269" /translation="MNNDAMEHTLGGGILTTSGSKQRKTSKFVMGKYTLYETKDRMYI VGSNKRETMFRILEIDLTVPRGELTVLEDNVFFTRNEIMNVLASLEEATEDGLHKKIT GYGLLGFIKFTCWYYLIMVTKYSQVAVIGGHGIYHIDGIDIIPITNNYKKPEKSSDEA RLLNIFKDLDLTKTFYFSYTYDITNTLQTNILREKLKAVDRCDITIPCGITDYNEMFV WNNNLLSPIFACIDTVFDWFQCIIHGFIDQVNVSVLGKSIYITLIARRSHHFAGARFL KRGVNNKGHVANEVETEQIVTDMILTPFHQPGNGFFDSDRYTSFVQHRGSIPLYWTQD ASNLTTKPPIRINVVDPFFSPAALHFDNLFQRYGGGTIQILNLIKTKEKTPRETKLLW EFEQCIDYLNEFLPTLKKLDYTSWDMSRASKQDGQGVIEFLEKYAVNTVTTTGIFHNG PDFASTKIQEGICRSNCIDCLDRTNAAQFVIGKRALGCQLKSLGIIDNSYLEYDSDIV NILTELFHDLGDTIALQYGGSHLVNTMETYRKINQWSSHSRDMIESIKRFYSNSFVDA QRQDAINLFLGHYSWREGFPSLWEMNTDFYLHNAYSLNMPKRSYIHWWNDYNIKSVKE LINEELIATGNDVTREKIIKNVRGYPGAFDNYWNEYYLPRSVTWIRDLFAYNMNSTRR YHNALSKQDKAMSPFTSRKQSWLNNKLKMITSSKSLEKAEGRVVETTDLDRDTSPKQE LELYEHYLHIISDRSQKLEEKMNSFSYSKYPIFISHESSEIPPMRKVIGEPLVDIAED FTDVYDDDDDGDDENDEMTTEALLIAPDHVSVDEKFYEKVLNVDDYKPALDDYSAVIH IKPDNLQLYRDLCFSKDIQLDFQ" gene 31944..33188 /gene="LEM3" /locus_tag="YNL323W" /gene_synonym="BRE3" /gene_synonym="ROS3" mRNA 31944..33188 /gene="LEM3" /locus_tag="YNL323W" /gene_synonym="BRE3" /gene_synonym="ROS3" /product="Lem3p" CDS 31944..33188 /gene="LEM3" /locus_tag="YNL323W" /gene_synonym="BRE3" /gene_synonym="ROS3" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12133835|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12133835]" /experiment="EXISTENCE:genetic interaction:GO:0044088 regulation of vacuole organization [PMID:25359886]" /experiment="EXISTENCE:mutant phenotype:GO:0007166 cell surface receptor signaling pathway [PMID:11063677]" /experiment="EXISTENCE:mutant phenotype:GO:0015247 aminophospholipid flippase activity [PMID:12133835]" /experiment="EXISTENCE:mutant phenotype:GO:0045332 phospholipid translocation [PMID:12842877]" /experiment="EXISTENCE:mutant phenotype:GO:0140345 phosphatidylcholine flippase activity [PMID:12133835]" /experiment="EXISTENCE:physical interaction:GO:1990531 phospholipid-translocating ATPase complex [PMID:15090616]" /note="Membrane protein of the plasma membrane and ER; interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane; null mutant requires tryptophan due to mislocalization of tryptophan permease Tat2p" /codon_start=1 /product="Lem3p" /protein_id="DAA10239.1" /db_xref="SGD:S000005267" /translation="MVNFDLGQVGEVFRRKDKGAIVSGDNPEEEEDVDASEFEEDEVK PVRTKNRRPKEDAFTQQRLAAINPVLTPRTVLPLYLLIAVVFVIVGGCILAQNSKVDE VTIYYQDCMTNATSSWSDIPSEHWQFVFHKYKTYNTAPQWRFVDDESDDFTKQRGTCQ IRFTTPSDMKNNVYLNYVLEKFAANHRRYVLSFSEDQIRGEDASYETVHDATGINCKP LSKNADGKIYYPCGLIANSMFNDTFPLQLTNVGDTSNNYSLTNKGINWESDKKRYKKT KYNYTQIAPPPYWEKMYPDGYNETNIPDIQDWEEFQNWMRPGAFDKITKLIRINKNDT LPAGEYQLDIGLHWPVLEFNGKKGIYLTHGSHLGGRNPFLGIVYLIGGCICAAMALIL LTFWLFGGRKIADASSLSWNMK" gene complement(33294..34235) /gene="KRE1" /locus_tag="YNL322C" mRNA complement(33294..34235) /gene="KRE1" /locus_tag="YNL322C" /product="Kre1p" CDS complement(33294..34235) /gene="KRE1" /locus_tag="YNL322C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11956747]" /note="Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor" /codon_start=1 /product="Kre1p" /protein_id="DAA10240.1" /db_xref="SGD:S000005266" /translation="MMRRTLLHSFATLLLSLSLWSAAVMAAVTTQVTVVTNVAGALVT ETTIWDPATAAAAATTTAQTGFFTTVFTTTNDVGTTVTLTQTVNRATMLPTTTTSTSS TGKTTTTVPTATSSLSSGLYLSTVTTTNDLGTTVTLTQTFTHSSTSATSSASSSVSSS VSSSGSSSSVKTTTSTGSAVAETGTRPDPSTDFTEPPVSAVTSLSIDSYITITEGTTS TYTTTRAPTSMWVTVVRQGNTITVQTTFVQRFSSQYVTVASPSVGSIGMGTLTGTVGV IKSAIKKTVSHNEAQHLGMSSFTSILGGLLTVLIWFL" gene 34696..37422 /gene="VNX1" /locus_tag="YNL321W" mRNA 34696..37422 /gene="VNX1" /locus_tag="YNL321W" /product="calcium/hydrogen antiporter" CDS 34696..37422 /gene="VNX1" /locus_tag="YNL321W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:17588950]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:20709757|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:20578725]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]" /experiment="EXISTENCE:mutant phenotype:GO:0006813 potassium ion transport [PMID:17588950]" /experiment="EXISTENCE:mutant phenotype:GO:0006814 sodium ion transport [PMID:17588950]" /experiment="EXISTENCE:mutant phenotype:GO:0015369 calcium:proton antiporter activity [PMID:20578725]" /experiment="EXISTENCE:mutant phenotype:GO:0015385 sodium:proton antiporter activity [PMID:17588950]" /experiment="EXISTENCE:mutant phenotype:GO:0015386 potassium:proton antiporter activity [PMID:17588950]" /experiment="EXISTENCE:mutant phenotype:GO:1902600 proton transmembrane transport [PMID:20578725]" /note="Calcium/H+ antiporter localized to endoplasmic reticulum membrane; member of calcium exchanger (CAX) family; targeted to vacuole via AP-3 pathway" /codon_start=1 /product="calcium/hydrogen antiporter" /protein_id="DAA10241.1" /db_xref="SGD:S000005265" /translation="MAKNNHISASGNSTSGDHRLKEEVLTPTTSASTPHRIFSVDDDP KEIQNDIRYLEGLHEGLKFALHANKSKRSVSSQSPIVHSSNNTLHHHEHQQHLPPTLE SLSSKSHSVPDLNTATPSSPKRMHSSIRELPHDDNDDEDANDDSRFIIHDSHGHDLLI DEINCQSPSHLENNDQASNASSTESFTLRERQDAINETHPFGIRIWKPALYKKHRSVQ RTAAQDIHETQLKTITWEVTCSNVLWFILFGFPIAILFYSAAIVVFLLGGGGLVTNSA KEYSKCLYKLANYFLWPFGKMVYLLQDEQYLQEDKDEGISMQQFYNWVTSYSNRLVFH QSQAKFQQREDHPAPATESSSLMPPANTTATPLNSNHPSYNSIRHEIPHAAAQRRYFG RGKWSWGRVLFYTIFHLVLQPILAVLSLCLWLLVFTIPMSNVLWQIMYHCRRHPLALG FKYVENSSQSHENEITQQQLNKNILLCTFRAAGWHYYKYTVDGTNVIVVNLISIVFFT IFDFYVLKNFLHWKTWFTYESSIFILCLTSTIPLAFYIGQAVASISAQTSMGVGAVIN AFFSTIVEIFLYCVALQQKKGLLVEGSMIGSILGAVLLLPGLSMCGGALNRKTQRYNP ASAGVSSALLIFSMIVMFVPTVLYEIYGGYSVNCADGANDRDCTFSHPPLKFNRLFTH VIQPMSISCAIVLFCAYIIGLWFTLRTHAKMIWQLPIADPTSTAPEQQEQNSHDAPNW SRSKSTCILLMSTLLYAIIAEILVSCVDAVLEDIPSLNPKFLGLTIFALIPNTTEFLN AISFAIHGNVALSMEIGSAYALQVCLLQIPSLVIYSIFYTWNVKKSMINIRTQMFPLV FPRWDIFGAMTSVFMFTYLYAEGKSNYFKGSMLILLYIIIVVGFYFQGALSE" gene 37700..38554 /locus_tag="YNL320W" mRNA 37700..38554 /locus_tag="YNL320W" /product="hypothetical protein" CDS 37700..38554 /locus_tag="YNL320W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10242.1" /db_xref="SGD:S000005264" /translation="MLWKVSKMFLGGLVALTTISVATLYHYQNRLVYPSWAQGARNHV DTPDSRGIPYEKLTLITQDHIKLEAWDIKNENSTSTVLILCPNAGNIGYFILIIDIFY RQFGMSVFIYSYRGYGNSEGSPSEKGLKLDADCVISHLSTDSFHSKRKLVLYGRSLGG ANALYIASKFRDLCDGVILENTFLSIRKVIPYIFPLLKRFTLLCHEIWNSEGLMGSCS SETPFLFLSGLKDEIVPPFHMRKLYETCPSSNKKIFEFPLGSHNDTIIQDGYWDIIRD FLIEKGFI" gene complement(38707..40329) /gene="HXT14" /locus_tag="YNL318C" mRNA complement(38707..40329) /gene="HXT14" /locus_tag="YNL318C" /product="Hxt14p" CDS complement(38707..40329) /gene="HXT14" /locus_tag="YNL318C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005354 galactose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]" /note="Protein with similarity to hexose transporter family members; expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /codon_start=1 /product="Hxt14p" /protein_id="DAA10243.1" /db_xref="SGD:S000005262" /translation="MTAQIPYQHSSGYISHFHNNELDAGRGRDYNVTIKYLDDKEENI EGQAAKISHNASLHIPVLLCLVISLGGFIFGWDIGTIGGMTNMVSFQEKFGTTNIIHD DETIFVSTKKLTDLQIGLIISIFNISCGVGALTLSKIGDWIGRKGGIWFALVVYCIGI TIQILSYGRWYFLTLGRAVTGIGVGVTTVLVPMFLSENSPLKIRGSMVSTYQLIVTFG ILMGNILNFICERCYKDPTQNIAWQLPLFLGYIWAIIIGMSLVYVPESPQYLAKIKND VPSAKYSFARMNGIPATDSMVIEFIDDLLENNYNNEETNNESKKQSLVKRNTFEFIMG KPKLWLRLIIGMMIMAFQQLSGINYFFYYGTSVFKGVGIKDPYITSIILSSVNFLSTI LGIYYVEKWGHKTCLLYGSTNLLFYMMTYATVGTFGRETDFSNIVLIIVTCCFIFWFA ITLGPVTFVLVSELFPLRTRAISMAICTFINWMFNFLISLLTPMIVSKIDFKLGYIFA ACLLALIIFSWILVPETRKKNEQEINKIFEPE" gene 40619..42016 /gene="PFS2" /locus_tag="YNL317W" mRNA 40619..42016 /gene="PFS2" /locus_tag="YNL317W" /product="cleavage polyadenylation factor subunit PFS2" CDS 40619..42016 /gene="PFS2" /locus_tag="YNL317W" /experiment="EXISTENCE:curator inference:GO:0003723 RNA binding [PMID:12819204]" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]" /experiment="EXISTENCE:direct assay:GO:0006397 mRNA processing [PMID:11344258]" /experiment="EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:10619842]" /note="Integral subunit of the pre-mRNA CPF complex; the cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex" /codon_start=1 /product="cleavage polyadenylation factor subunit PFS2" /protein_id="DAA10244.1" /db_xref="SGD:S000005261" /translation="MDGHNQNQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYY NRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWT PEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIK IWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGH HWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNL LMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDL LQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPT YNNKKINGWFFGINNDINAVREKSEFGAAPPPPATLEPHALPNMNGFINKKPRQEIPG IDSNIKSSTLPGLSI" gene complement(42071..43075) /gene="PHA2" /locus_tag="YNL316C" mRNA complement(42071..43075) /gene="PHA2" /locus_tag="YNL316C" /product="prephenate dehydratase PHA2" CDS complement(42071..43075) /gene="PHA2" /locus_tag="YNL316C" /EC_number="4.2.1.51" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004664 prephenate dehydratase activity [PMID:1532796]" /experiment="EXISTENCE:mutant phenotype:GO:0009094 L-phenylalanine biosynthetic process [PMID:1532796]" /note="Prephenate dehydratase; catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway" /codon_start=1 /product="prephenate dehydratase PHA2" /protein_id="DAA10245.1" /db_xref="SGD:S000005260" /translation="MASKTLRVLFLGPKGTYSHQAALQQFQSTSDVEYLPAASIPQCF NQLENDTSIDYSVVPLENSTNGQVVFSYDLLRDRMIKKALSLPAPADTNRITPDIEVI AEQYVPITHCLISPIQLPNGIASLGNFEEVIIHSHPQVWGQVECYLRSMAEKFPQVTF IRLDCSSTSESVNQCIRSSTADCDNILHLAIASETAAQLHKAYIIEHSINDKLGNTTR FLVLKRRENAGDNEVEDTGLLRVNLLTFTTRQDDPGSLVDVLNILKIHSLNMCSINSR PFHLDEHDRNWRYLFFIEYYTEKNTPKNKEKFYEDISDKSKQWCLWGTFPRNERYYHK " gene complement(43324..44280) /gene="ATP11" /locus_tag="YNL315C" mRNA complement(43324..44280) /gene="ATP11" /locus_tag="YNL315C" /product="Atp11p" CDS complement(43324..44280) /gene="ATP11" /locus_tag="YNL315C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:1532796]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:12829692|PMID:10681564]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:2142305]" /experiment="EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:2142305]" /experiment="EXISTENCE:physical interaction:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:10681564]" /note="Molecular chaperone; required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; N-terminally propionylated in vivo" /codon_start=1 /product="Atp11p" /protein_id="DAA10246.1" /db_xref="SGD:S000005259" /translation="MWRLTRKIGTRIHISNQLSPIFNKAIGTVPVFRFYSSSPEQKYR KKLLEEAQKQGFNSIEELKNHLKETIESKKREFNKIDPLKELEDYQQKTQMENNNSKH LMTKSRSPLDPSAPKVPFKTLDSFLDVGKLKDLSKQEVEFLWRARWAQKDNTLCAVIP VSVYDKMMANARNNPIFVLPLPRQVQSEDAKPNEEQGMELHYIQWQFVGPQTTHCMMT SLAEYKLHQEFARPHTTLQFHSDLVKDKGIVFMNGHVEPDTNVNVQDAQLLLLNVQRF YGAMGEETPVAKQRVQLLRDFSKASPGFTVEKLISLSQSMEN" gene 44447..45214 /gene="DAL82" /locus_tag="YNL314W" mRNA 44447..45214 /gene="DAL82" /locus_tag="YNL314W" /product="Dal82p" CDS 44447..45214 /gene="DAL82" /locus_tag="YNL314W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10702289]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:8367295]" /experiment="EXISTENCE:mutant phenotype:GO:0000256 allantoin catabolic process [PMID:1898922]" /experiment="EXISTENCE:mutant phenotype:GO:0043565 sequence-specific DNA binding [PMID:10702289]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10906145]" /experiment="EXISTENCE:physical interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10906145]" /note="Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain" /codon_start=1 /product="Dal82p" /protein_id="DAA10247.1" /db_xref="SGD:S000005258" /translation="MDESVDPVELLLRLLIRHKPHLKPYAYRQDSWQRVLDEYNRQTG SRYRQSRTLKTKFRRLKDLFSADRAQFSPSQLKLMGALLDEAPEHPRPRTKFGNESSS SLSSSSFIKSHPGPDPFQQLSSAEHPNNHSSDDEHSGSQPLPLDSITIGIPPTLHTIP MILSKDNDVGKVIKSPKINKGTNRFSETVLPPQMAAEQSWSDSNMELEICLDYLHNEL EVIKKRQEDFECKVLNKLNIIEALLSQMRPPSQGDKI" gene complement(45308..48022) /gene="EMW1" /locus_tag="YNL313C" mRNA complement(45308..48022) /gene="EMW1" /locus_tag="YNL313C" /product="tetratricopeptide repeat-containing protein EMW1" CDS complement(45308..48022) /gene="EMW1" /locus_tag="YNL313C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:14690591|PMID:21273246]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21273246|PMID:14690591|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:21273246]" /note="Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="tetratricopeptide repeat-containing protein EMW1" /protein_id="DAA10248.1" /db_xref="SGD:S000005257" /translation="METLLHAKLLLSAEVESLKSGSFDQTYVKKAEHIISGESYQLVQ QFVDKFKGKISISGEISTSSVIAALNDFLNVEVFKMGQENEMLFLAIALLQTFIQNNY TGPAARLKAISGLFGKTGIEIGAVNTALSRSLAIMGQPAYEFMDDPLYLVLSLLLLER ITGQKSLFDVTPDQEIPLPIISAESTPGLLAVAYWWWARALLTQLSLIPEPSGFQASV ASAIYQSADLAYAITKELPESIHEDFKRELCAMYYLENVKCSLAINTEHLCLPSLTRA KKITNFEFVMTGARATRTKYQQKAHAGLIILAKSFTFQNFALRTTSATPETFALESDL LLEKPHFESIADEPLDEQIYSKRQKVDLNEGYEEDKLLPLALRQENIPKLLLDLNPND QPTLSDYDNIQLLLRLYTIKNTTPAKDPLVEEELTALLSRILYQNGDKNWSIFARSLW ERSIIETTKAKTIERGLLQMQSLVEELDLKIKSKLVPSSSEINVASRLSYIHQLPFIP RWQLDATLAEKYMSLGILKSAVEIYERLGMACETALCYAAVGDEKKAEEILLQRINEN DSDARAYSILGDIKQDPSLWEKSWEIGKYVNAKNSLAKYYFNPPPKSGAQPNYSATLK HLNDSLRQYPLSFETWYFYGCVGLQCGKMQIAAEAFTRCVSLDPYHALSWSNLSAAYT KMDKLKEAYSCLKRAISCDAQKNWKIWENYMLVAVKLNEWEDVLTACKQLVSIRRDKS GEGSIDLPIIEKLVELLVTSEYPEEPQQLSYFQKSCTEFICNTLPQVITTSARCWRLV ARVELWRKRPWAALECHEKAYRAISHNPDLEVEEKVWNDTVDACEDLVAAYESLGEME GKYGPGSLVCKDWKYKCRSTIKALMSKGKGRWDDSPGWDRLVEARSQI" gene 48287..49216 /gene="RFA2" /locus_tag="YNL312W" /gene_synonym="BUF1" /gene_synonym="RPA2" /gene_synonym="RPA32" mRNA join(48287..48293,48402..49216) /gene="RFA2" /locus_tag="YNL312W" /gene_synonym="BUF1" /gene_synonym="RPA2" /gene_synonym="RPA32" /product="Rfa2p" CDS join(48287..48293,48402..49216) /gene="RFA2" /locus_tag="YNL312W" /gene_synonym="BUF1" /gene_synonym="RPA2" /gene_synonym="RPA32" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:9679065]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:7761422]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:8804316]" /experiment="EXISTENCE:direct assay:GO:0005662 DNA replication factor A complex [PMID:2554144]" /experiment="EXISTENCE:direct assay:GO:0006260 DNA replication [PMID:2554144]" /experiment="EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:22885009]" /experiment="EXISTENCE:direct assay:GO:0006289 nucleotide-excision repair [PMID:8910442]" /experiment="EXISTENCE:direct assay:GO:0030491 heteroduplex formation [PMID:12226081]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:7761422]" /experiment="EXISTENCE:genetic interaction:GO:0000724 double-strand break repair via homologous recombination [PMID:9679065]" /experiment="EXISTENCE:mutant phenotype:GO:0000781 chromosome, telomeric region [PMID:14702040]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:9093844]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:9093844]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:8910442]" /experiment="EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:14702040]" /experiment="EXISTENCE:mutant phenotype:GO:0010833 telomere maintenance via telomere lengthening [PMID:22354040]" /experiment="EXISTENCE:mutant phenotype:GO:0045184 establishment of protein localization [PMID:14702040]" /experiment="EXISTENCE:physical interaction:GO:0000722 telomere maintenance via recombination [PMID:2554144]" /experiment="EXISTENCE:physical interaction:GO:0006312 mitotic recombination [PMID:2554144]" /experiment="EXISTENCE:physical interaction:GO:0007131 reciprocal meiotic recombination [PMID:2554144]" /experiment="EXISTENCE:physical interaction:GO:0016567 protein ubiquitination [PMID:18342608]" /note="Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; in concert with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication s" /codon_start=1 /product="Rfa2p" /protein_id="DAA10249.1" /db_xref="SGD:S000005256" /translation="MATYQPYNEYSSVTGGGFENSESRPGSGESETNTRVNTLTPVTI KQILESKQDIQDGPFVSHNQELHHVCFVGVVRNITDHTANIFLTIEDGTGQIEVRKWS EDANDLAAGNDDSSGKGYGSQVAQQFEIGGYVKVFGALKEFGGKKNIQYAVIKPIDSF NEVLTHHLEVIKCHSIASGMMKQPLESASNNNGQSLFVKDDNDTSSGSSPLQRILEFC KKQCEGKDANSFAVPIPLISQSLNLDETTVRNCCTTLTDQGFIYPTFDDNNFFAL" gene complement(49397..51688) /gene="SKP2" /locus_tag="YNL311C" mRNA complement(49397..51688) /gene="SKP2" /locus_tag="YNL311C" /product="putative SCF ubiquitin ligase complex subunit SKP2" CDS complement(49397..51688) /gene="SKP2" /locus_tag="YNL311C" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:20936605]" /experiment="EXISTENCE:mutant phenotype:GO:0031335 regulation of sulfur amino acid metabolic process [PMID:20936605]" /experiment="EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994]" /note="F-box hypothetical protein; predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments" /codon_start=1 /product="putative SCF ubiquitin ligase complex subunit SKP2" /protein_id="DAA10250.1" /db_xref="SGD:S000005255" /translation="MKRLQLFGRSKYFSLVSSAAKEEEEEEEGCADAKSLLHSTSHDI KSRSLRFNDKSSLMCLPTKVLLLILRTLDFNTLVTLCQVNSRFYNLITNEFLFQNVIL DSKLSLLKFNALIHSEFHTSNIVTHSGDCSTQSRSQNARFLVRSIEFKNPQSQDSLLK YSKFYNKSGQDSIIAGSYKLDSYDKDVKKLNNIRLNDETPIITSERIKLLDKLESNYF HYTYIELMLDIIDYLPNLTRVILSDVEPNFKIPLWYSVFNDGSRDFFKKIIKGQQSIT NEDLRTFQLSKKFVKEYESKYYSLPRLKILEIKANNKRQRTFNRQRHHQKLVLRPSLF CCFGIINELKLENVTIDTESLDTPMEFLPLFLKNEDNELYSLQSPITALTLDSCDVVP GNGILRLFHSYFKMVKHLSLLKINSKFDLLLCSCFPSLSNLTIDCNSKCFTNEQVVGE SYYFQQRSLDTEDDFDDCNSMTETLFEAPSDSKIITPPPTSSVVLSLNLNYISRTTGN DVSNNPSPDNNKKPAMLTAAQLQNFQRQRIPEFHSFYHYYRLLWERLPSKNISINVIN IPFTNVYPLSPLSFWEHLARTITSVDETDEDVGDENDQETLIGYENNSIRDNIPNANA VPNLSTVMSPESDIHHTYYWNNSVRRCLRDSLIKLKNRTIEYRDLDVEEFLQNVTLEN FFNDFQDPENFKDIPNINLWCFLRNLSKFKAVKIRMLRHFSLCTPRTRYDWELLLKPV LRVNVPIEVRDKDGFVLYSYGQK" gene complement(51907..52431) /gene="ZIM17" /locus_tag="YNL310C" /gene_synonym="HEP1" /gene_synonym="TIM15" mRNA complement(51907..52431) /gene="ZIM17" /locus_tag="YNL310C" /gene_synonym="HEP1" /gene_synonym="TIM15" /product="Zim17p" CDS complement(51907..52431) /gene="ZIM17" /locus_tag="YNL310C" /gene_synonym="HEP1" /gene_synonym="TIM15" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:15992824|PMID:15383543]" /experiment="EXISTENCE:direct assay:GO:0051087 protein-folding chaperone binding [PMID:15719019]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:15719019]" /experiment="EXISTENCE:mutant phenotype:GO:0006986 response to unfolded protein [PMID:15992824]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:15719019]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:15383543]" /experiment="EXISTENCE:mutant phenotype:GO:0050821 protein stabilization [PMID:16460754]" /note="Protein co-chaperone with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix; required for the maintenance of Ssc1p solubility and assists in the functional interaction of Ssc1p with substrate proteins" /codon_start=1 /product="Zim17p" /protein_id="DAA10251.1" /db_xref="SGD:S000005254" /translation="MIPRTRTLLQSKIPITRYFARCWAPRVRYNVCRTLPAAALHTNI IAHNEVKKDDKKVHLGSFKVDKPKMMIAFTCKKCNTRSSHTMSKQAYEKGTVLISCPH CKVRHLIADHLKIFHDHHVTVEQLMKANGEQVSQDVGDLEFEDIPDSLKDVLGKYAKN NSENASQLPHPSQK" gene 52662..53924 /gene="STB1" /locus_tag="YNL309W" mRNA 52662..53924 /gene="STB1" /locus_tag="YNL309W" /product="Stb1p" CDS 52662..53924 /gene="STB1" /locus_tag="YNL309W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030907 MBF transcription complex [PMID:18794370]" /experiment="EXISTENCE:direct assay:GO:0033309 SBF transcription complex [PMID:18794370]" /experiment="EXISTENCE:direct assay:GO:0070822 Sin3-type complex [PMID:9393435]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:10409718]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:10409718]" /experiment="EXISTENCE:genetic interaction:GO:0031496 positive regulation of mating type switching [PMID:9393435]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9393435]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:18794370]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:18794370]" /experiment="EXISTENCE:physical interaction:GO:0003713 transcription coactivator activity [PMID:18794370|PMID:10409718|PMID:12832490]" /experiment="EXISTENCE:physical interaction:GO:0070822 Sin3-type complex [PMID:9393435]" /note="Protein with role in regulation of MBF-specific transcription at Start; phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p, which is required for Stb1p function; expression is cell-cycle regulated; STB1 has a paralog, YOL131W, that arose from the whole genome duplication" /codon_start=1 /product="Stb1p" /protein_id="DAA10252.1" /db_xref="SGD:S000005253" /translation="MSQPQMSPEKEQELASKILHRAELAQMTRQLKLGLSNVPSTKRK QDSTTKKRSGEDAEDVDEDHKTLLEAISPAKKPLHDDTNKMTVISPVKFVEKPNTPPS SRQRKAEDRSQQIKPRKEDTPSTPRASATPIILPHASSHYQRPHDKNFMTPKRNNNNS SNHSNNNNNIKKKAAGSKDAPQDSDNTAGADLLMYLATSPYNKSSHHGTPMAVRMPTT PRSYHYASQLSLNGNTASTSNDAVRFSHIKPSASSPQSTFKSNLLPNFPDESLMDSPS LYLSNNNGSVQATLSPQQRRKPTTNTLHPPSNVPTTPSRELNGTNFNLLRTPNFNMGD YLHNLFSPSPRVPAQQGASNTSASIPSVPAMVPGSSSNTSAIATAAISSHTTNNFLDM NANGIPLIVGPGTDRIGEGESIDDKLTD" gene complement(54122..55897) /gene="KRI1" /locus_tag="YNL308C" mRNA complement(54122..55897) /gene="KRI1" /locus_tag="YNL308C" /product="Kri1p" CDS complement(54122..55897) /gene="KRI1" /locus_tag="YNL308C" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11027267]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:22180534]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11027267]" /note="Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p" /codon_start=1 /product="Kri1p" /protein_id="DAA10253.1" /db_xref="SGD:S000005252" /translation="MPRKKSAAKRAREQAKKEAAVPATDTATIKTSETSATTVKPAIE ASKSYVPSEDEEEDEEEEEEEDDYGELITDEVENGINQVLDAIKNNKTDKLLDPKVKF FEDPESAAAKLANREGKHKPIYLKDYHRMNILSGDALKEDDEEYEHATVDGKQSFVSQ QREEKTQLLNEIKSAFSDEENEESSGDEDDGFLKKKEPSTKKEGKNLPDPTVNEENFL EEFVNQQAWIPKKGDKVISLDLNNNEEDDEEFEDAAEKFENAYNFRYEDPNAAEIISY ARSQATLRRSDDSSRRRKREEKRKIKEQIKAEKETALQKKKTKKLNKLTDILEQLTKE YGAEINADMVKKITDTLLKNDFKEEEWDNVVAELFNEEFYQQEGKPTWNEDDEIMGDF YADADGDDQTEEGEVEKEQKEEDEEEGPKRKKSKKEEKLQKKKEKRKVNELVENALEQ NKLALIEEVEKEEEERKSRSRTKEEQDLKFRYREVSPESFGLTAREIFAADDTDLNEF IGLKKFAPYRSKELRAKDKRKVMKARRLREWRKKTFKNENGLAPVEAEAGEKDEDTIL IPVEKASKSKHKRGHSHKHKGHQKK" gene complement(56446..57573) /gene="MCK1" /locus_tag="YNL307C" /gene_synonym="CMS1" /gene_synonym="YPK1" mRNA complement(56446..57573) /gene="MCK1" /locus_tag="YNL307C" /gene_synonym="CMS1" /gene_synonym="YPK1" /product="serine/threonine/tyrosine protein kinase MCK1" CDS complement(56446..57573) /gene="MCK1" /locus_tag="YNL307C" /gene_synonym="CMS1" /gene_synonym="YPK1" /EC_number="2.7.12.1" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:23314252]" /experiment="EXISTENCE:direct assay:GO:0004712 protein serine/threonine/tyrosine kinase activity [PMID:8407952]" /experiment="EXISTENCE:genetic interaction:GO:0030163 protein catabolic process [PMID:23236290|PMID:17954914]" /experiment="EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:36321416]" /experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:2010084]" /experiment="EXISTENCE:mutant phenotype:GO:0004857 enzyme inhibitor activity [PMID:22918234]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:12399380]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:17954914|PMID:23236290]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:2010083]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:2010083]" /experiment="EXISTENCE:physical interaction:GO:0030332 cyclin binding [PMID:22918234]" /note="Dual-specificity S/T and tyrosine protein kinase; spindle position checkpoint component that works in parallel with Kin4p to prevent mitotic exit network (MEN) activation by the Cdc14 early anaphase release (FEAR) network; roles in chromosome segregation, meiotic entry, genome stability, phosphorylation-dependent degradation of Rcn1p and Cdc6p, inhibition of protein kinase A, transcriptional regulation, inhibition of RNAPIII, calcium stress and inhibition of Clb2p-Cdc28p after nuclear division" /codon_start=1 /product="serine/threonine/tyrosine protein kinase MCK1" /protein_id="DAA10254.1" /db_xref="SGD:S000005251" /translation="MSTEEQNGVPLQRGSEFIADDVTSNKSNNTRRMLVKEYRKIGRG AFGTVVQAYLTQDKKNWLGPFAIKKVPAHTEYKSRELQILRIADHPNIVKLQYFFTHL SPQDNKVYQHLAMECLPETLQIEINRYVTNKLEMPLKHIRLYTYQIARGMLYLHGLGV CHRDIKPSNVLVDPETGVLKICDFGSAKKLEHNQPSISYICSRFYRAPELIIGCTQYT TQIDIWGLGCVMGEMLIGKAIFQGQEPLLQLREIAKLLGPPDKRFIFFSNPAYDGPLF SKPLFSGSSQQRFEKYFGHSGPDGIDLLMKILVYEPQQRLSPRRILAHQFFNELRNDD TFLPRGFTEPIKLPNLFDFNDFELQILGEFADKIKPTKVAE" gene 58155..58808 /gene="MRPS18" /locus_tag="YNL306W" /gene_synonym="uS11m" mRNA 58155..58808 /gene="MRPS18" /locus_tag="YNL306W" /gene_synonym="uS11m" /product="mitochondrial 37S ribosomal protein YmS18" CDS 58155..58808 /gene="MRPS18" /locus_tag="YNL306W" /gene_synonym="uS11m" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552|PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552|PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:12392552|PMID:9151978]" /note="Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins" /codon_start=1 /product="mitochondrial 37S ribosomal protein uS11m MRPS18" /protein_id="DAA10255.1" /db_xref="SGD:S000005250" /translation="MLLQPVWKGCRWTQFVRPIRRWNSTGTNRGVPFSFKDISNQEDI TNISYPSSSDSVLTKSNGSSEVYKPKEEVVKYILHGKFTKNNTHLTFSSVVEDKNFHK NKGLTYNDTMLYYLNLPQKVKISLSTGCLGFRKAARGEYEAAFQTSGRMFELIKEKNM LNKDIEVVMDDFGKGRAAFISALVGKEGASVVKKVVKISDATKLKFGGVRSPKMRRL" gene complement(58898..59791) /gene="BXI1" /locus_tag="YNL305C" /gene_synonym="YBH3" mRNA complement(58898..59791) /gene="BXI1" /locus_tag="YNL305C" /gene_synonym="YBH3" /product="Bxi1p" CDS complement(58898..59791) /gene="BXI1" /locus_tag="YNL305C" /gene_synonym="YBH3" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:21673659|PMID:21673967|PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:21673659]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:21673967]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:21673967|PMID:21673659]" /experiment="EXISTENCE:mutant phenotype:GO:0019722 calcium-mediated signaling [PMID:21673967]" /experiment="EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:21673967]" /note="Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p" /codon_start=1 /product="Bxi1p" /protein_id="DAA10256.1" /db_xref="SGD:S000005249" /translation="MSGPPPPYEEQSSHLYGQPASSQDGNAFIPEDFKYSTVVISCEP IIRQRFMHKVYSLLSCQLLASLSFCYWASVSTSLQNFIMSHIALFYICMVVSLVSCIW LAVSPRPEDYEASVPEPLLTGSSEEPAQEQRRLPWYVLSSYKQKLTLLSIFTLSEAYC LSLVTLAYDKDTVLSALLITTIVVVGVSLTALSERFENVLNSATSIYYWLNWGLWIMI GMGLTALLFGWNTHSSKFNLLYGWLGAILFTAYLFIDTQLIFRKVYPDEEVRCAMMLY LDIVNLFLSILRILANSNDDN" gene 60297..61550 /gene="YPT11" /locus_tag="YNL304W" mRNA 60297..61550 /gene="YPT11" /locus_tag="YNL304W" /product="Rab family GTPase YPT11" CDS 60297..61550 /gene="YPT11" /locus_tag="YNL304W" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:12391144]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:23427260]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16980630|PMID:23427260]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12391144|PMID:23427260]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12391144|PMID:23427260]" /experiment="EXISTENCE:direct assay:GO:0048309 endoplasmic reticulum inheritance [PMID:23427260]" /experiment="EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:18245340|PMID:23427260|PMID:12391144|PMID:15201867]" /experiment="EXISTENCE:genetic interaction:GO:0048312 intracellular distribution of mitochondria [PMID:12391144|PMID:15201867]" /experiment="EXISTENCE:genetic interaction:GO:0048313 Golgi inheritance [PMID:18595704]" /experiment="EXISTENCE:genetic interaction:GO:0090167 Golgi distribution to daughter cells [PMID:18595704]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:18245340|PMID:12391144]" /experiment="EXISTENCE:mutant phenotype:GO:0048309 endoplasmic reticulum inheritance [PMID:16980630|PMID:23427260]" /experiment="EXISTENCE:mutant phenotype:GO:0048312 intracellular distribution of mitochondria [PMID:12391144]" /experiment="EXISTENCE:mutant phenotype:GO:0048313 Golgi inheritance [PMID:18595704]" /experiment="EXISTENCE:mutant phenotype:GO:0051646 mitochondrion localization [PMID:23139336]" /experiment="EXISTENCE:mutant phenotype:GO:0090167 Golgi distribution to daughter cells [PMID:18595704]" /experiment="EXISTENCE:physical interaction:GO:0031489 myosin V binding [PMID:12391144]" /note="Rab GTPase; Myo2p-binding protein implicated in mother-to-bud transport of cortical endoplasmic reticulum (ER), late Golgi, and mitochondria during cell division; function is regulated at multiple levels; abundance of active Ypt11p forms is controlled by phosphorylation status and degradation; normally a low-abundance protein whose ER localization is only detected when protein is highly over expressed" /codon_start=1 /product="Rab family GTPase YPT11" /protein_id="DAA10257.1" /db_xref="SGD:S000005248" /translation="MSQRKRYSLNVVTSPSIPSPTPSAPIRTNESNWEAASPASAASS FLPNVHHGGTVLNPGLGIMRSPSLNKSGAFGRSGSSGSSTVIEPSNIKLLLIGDANVG KTAMILSYCRELLTRAEMSRSARLRHQQQQQHKDLGLKKTVVNHRLSMKEKRKRYSSN DFEKEFKDINHFADETSDFGNPNIGDDNNHEMADPNEIVIETRSTIGIDIKTNLVNID NRFFNVILWDTAGQERYQNAIIPSLYKKTNAVILTYDITNAKSFQSCMERWIVQALEN FSSQDLLKARFFLVGNKIDLYKERQVTHYDVVQMVQEMQLKHGIKISGNFEVSCKWVN VVERTMNMIILDLVENGCFENNDPCVSITTSDDVQGHEQEFHDTVEEPFNFTRQRQHQ LEKNNTVDITKPNDDIANNQSICCV" rep_origin 61599..61895 /note="ARS1406; Autonomously Replicating Sequence" /db_xref="SGD:S000118383" gene complement(61958..62943) /gene="RPS19B" /locus_tag="YNL302C" /gene_synonym="RP55B" mRNA complement(join(61958..62372,62924..62943)) /gene="RPS19B" /locus_tag="YNL302C" /gene_synonym="RP55B" /product="40S ribosomal protein eS19 RPS19B" CDS complement(join(61958..62372,62924..62943)) /gene="RPS19B" /locus_tag="YNL302C" /gene_synonym="RP55B" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:16159874|PMID:16246728]" /experiment="EXISTENCE:genetic interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:16159874]" /experiment="EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:16159874]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:16159874]" /note="Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19B has a paralog, RPS19A, that arose from the whole genome duplication" /codon_start=1 /product="40S ribosomal protein eS19 RPS19B" /protein_id="DAA10258.1" /db_xref="SGD:S000005246" /translation="MAGVSVRDVAAQDFINAYASFLQRQGKLEVPGYVDIVKTSSGNE MPPQDAEGWFYKRAASVARHIYMRKQVGVGKLNKLYGGAKSRGVRPYKHIDASGSINR KVLQALEKIGIVEISPKGGRRISENGQRDLDRIAAQTLEEDE" gene complement(63570..64562) /gene="RPL18B" /locus_tag="YNL301C" /gene_synonym="RP28B" mRNA complement(join(63570..64018,64451..64562)) /gene="RPL18B" /locus_tag="YNL301C" /gene_synonym="RP28B" /product="60S ribosomal protein eL18 RPL18B" CDS complement(join(63570..64018,64451..64562)) /gene="RPL18B" /locus_tag="YNL301C" /gene_synonym="RP28B" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication" /codon_start=1 /product="60S ribosomal protein eL18 RPL18B" /protein_id="DAA10259.1" /db_xref="SGD:S000005245" /translation="MGIDHTSKQHKRSGHRTAPKSDNVYLKLLVKLYTFLARRTDAPF NKVVLKALFLSKINRPPVSVSRIARALKQEGAANKTVVVVGTVTDDARIFEFPKTTVA ALRFTAGARAKIVKAGGECITLDQLAVRAPKGQNTLILRGPRNSREAVRHFGMGPHKG KAPRILSTGRKFERARGRRRSKGFKV" gene 65744..66052 /gene="TOS6" /locus_tag="YNL300W" mRNA 65744..66052 /gene="TOS6" /locus_tag="YNL300W" /product="Tos6p" CDS 65744..66052 /gene="TOS6" /locus_tag="YNL300W" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /note="Glycosylphosphatidylinositol-dependent cell wall protein; expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid" /codon_start=1 /product="Tos6p" /protein_id="DAA10260.1" /db_xref="SGD:S000005244" /translation="MKFSTLSTVAAIAAFASADSTSDGVTYVDVTTTPQSTTSMVSTV KTTSTPYTTSTIATLSTKSISSQANTTTHEISTYVGAAVKGSVAGMGAIMGAAAFALL " gene 66517..68445 /gene="TRF5" /locus_tag="YNL299W" mRNA 66517..68445 /gene="TRF5" /locus_tag="YNL299W" /product="non-canonical poly(A) polymerase TRF5" CDS 66517..68445 /gene="TRF5" /locus_tag="YNL299W" /EC_number="2.7.7.19" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031499 TRAMP complex [PMID:16374505]" /experiment="EXISTENCE:direct assay:GO:1990817 poly(A) RNA polymerase activity [PMID:16374505|PMID:16260630]" /experiment="EXISTENCE:genetic interaction:GO:0034475 U4 snRNA 3'-end processing [PMID:16373491]" /experiment="EXISTENCE:genetic interaction:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:17652137|PMID:15935758]" /experiment="EXISTENCE:genetic interaction:GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process [PMID:16373491|PMID:15935758]" /experiment="EXISTENCE:genetic interaction:GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process [PMID:15935758]" /experiment="EXISTENCE:genetic interaction:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:16431988]" /experiment="EXISTENCE:genetic interaction:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:18007593]" /experiment="EXISTENCE:genetic interaction:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:16373491]" /experiment="EXISTENCE:genetic interaction:GO:0071044 histone mRNA catabolic process [PMID:17179095]" /experiment="EXISTENCE:genetic interaction:GO:0071051 poly(A)-dependent snoRNA 3'-end processing [PMID:16373491]" /experiment="EXISTENCE:genetic interaction:GO:1990817 poly(A) RNA polymerase activity [PMID:16374505]" /experiment="EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:16373491]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:15935758|PMID:18007593]" /experiment="EXISTENCE:mutant phenotype:GO:1990817 poly(A) RNA polymerase activity [PMID:16374505]" /note="Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p" /codon_start=1 /product="non-canonical poly(A) polymerase TRF5" /protein_id="DAA10261.1" /db_xref="SGD:S000005243" /translation="MTRLKAKYSPTKGKRKEDKHTKRMRKSSFTRTQKMLEVFNDNRS HFNKYESLAIDVEDDDTFGNLVLMENDKSDVDIPVIEEVTSSEDEQRAESSKRNNSLE DNQDFIAFSDSSEDETEQIKEDDDERSSFLLTDEHEVSKLTSQQSLNTESACNVEYPW IRNHCHSKQRRIADWLTSEIKDFVHYISPSKNEIKCRNRTIDKLRRAVKELWSDADLH VFGSFATDLYLPGSDIDCVVNSRNRDKEDRNYIYELARHLKNKGLAIRMEVIVKTRVP IIKFIEPQSQLHIDVSFERTNGLEAAKLIREWLRDSPGLRELVLIIKQFLHSRRLNNV HTGGLGGFTVICLVYSFLNMHPRIKSNDIDVLDNLGVLLIDFFELYGKNFGYDDVAIS ISDGYASYIPKSCWRTLEPSRSKFSLAIQDPGDPNNNISRGSFNMKDIKKAFAGAFEL LVNKCWELNSATFKDRVGKSILGNVIKYRGQKRDFNDERDLVQNKAIIENERYHKRRT RIVQEDLFINDTEDLPVEEIYKLDEPAKKKQKAKKDKREGEIKKSAIPSPPPDFGVSR SKLKRKVKKTDQGSLLHQNNLSIDDLMGLSENDQESDQDQKGRDTPSGQDEKSPLETK TVDAQTRRDYWLSKGQAL" gene 68915..71443 /gene="CLA4" /locus_tag="YNL298W" /gene_synonym="ERC10" mRNA 68915..71443 /gene="CLA4" /locus_tag="YNL298W" /gene_synonym="ERC10" /product="serine/threonine protein kinase CLA4" CDS 68915..71443 /gene="CLA4" /locus_tag="YNL298W" /gene_synonym="ERC10" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0000278 mitotic cell cycle [PMID:22588722]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:19218422]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:22588722]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:19218422]" /experiment="EXISTENCE:direct assay:GO:0016301 kinase activity [PMID:14993234]" /experiment="EXISTENCE:genetic interaction:GO:0000011 vacuole inheritance [PMID:19218422]" /experiment="EXISTENCE:genetic interaction:GO:0010629 negative regulation of gene expression [PMID:19793923]" /experiment="EXISTENCE:genetic interaction:GO:0019236 response to pheromone [PMID:17189484]" /experiment="EXISTENCE:genetic interaction:GO:0031106 septin ring organization [PMID:7649470]" /experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:19218422]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:0007096 regulation of exit from mitosis [PMID:12234925]" /experiment="EXISTENCE:mutant phenotype:GO:0010629 negative regulation of gene expression [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:0031106 septin ring organization [PMID:11025657]" /experiment="EXISTENCE:mutant phenotype:GO:0035376 sterol import [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:0042307 positive regulation of protein import into nucleus [PMID:22588722]" /experiment="EXISTENCE:mutant phenotype:GO:2000910 negative regulation of sterol import [PMID:19793923]" /note="Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication" /codon_start=1 /product="serine/threonine protein kinase CLA4" /protein_id="DAA10262.1" /db_xref="SGD:S000005242" /translation="MSLSAAANKISDNDFQNIGPAPRPPSSNSQGRTCYNQTQPITKL MSQLDLTSASHLGTSTSKKKSGWVSYKDDGILSFIWQKRYLMLHDSYVALYKNDKQND DAILKIPLTSIISVSRTQLKQYCFELVRCSDRNSVSSGSSSSLNVSSDSNSKKSIYIA TKTESDLHSWLDAIFAKCPLLSGVSSPTNFTHKVHVGFDPETGSFVGMPTNWEKLLKH SRITGEDWNNNSAAVIQVLQFYQEYNGAGNPTNTLDKPQSGETSSSQKSLPNSYNDNK LRNNSVNSKSSSGVSSSMVSQRKTSQPPNTKSPVSLGSGSLPPINTKLPTSQSNIPRH LQNVPNQQYPKMRNGHSPTNGQFPRGPMHPNNSQRSLQQQQQQQQQQKQQHQQYPYHH QGPSPSPSPSPSPLNPYRPHHNMINPYSKQPQSPLSSQSTQNQAIPRYAQNSSPTAAH FQPQRTAPKPPISAPRAPYPSNQNATSNTHVQPVAPKNDQSTPQTMRQAPKRPDADVA QPGGVAKPKKPARPTMSTAEIMSKLKKVTVNADPSQCFKVIEKAGQGASGSVYLAERT HIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKDSRHKNIVN FLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLK FLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGTPYWMAPEVV KQREYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLKHPESLSLEI KRFLSVCLCVDVRYRASTEELLHHGFFNMACDPKDLTSLLEWKE" gene complement(71673..76583) /gene="MON2" /locus_tag="YNL297C" /gene_synonym="YSL2" mRNA complement(71673..76583) /gene="MON2" /locus_tag="YNL297C" /gene_synonym="YSL2" /product="Mon2p" CDS complement(71673..76583) /gene="MON2" /locus_tag="YNL297C" /gene_synonym="YSL2" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:12052896]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:16301316]" /experiment="EXISTENCE:direct assay:GO:0006623 protein targeting to vacuole [PMID:16219684]" /experiment="EXISTENCE:direct assay:GO:0031901 early endosome membrane [PMID:16219684]" /experiment="EXISTENCE:genetic interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:12052896]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:12052896]" /experiment="EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:16301316]" /experiment="EXISTENCE:physical interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:12052896]" /note="Protein with a role in endocytosis and vacuole integrity; peripheral membrane protein; interacts with and negatively regulates Arl1p; localizes to the endosome; member of the Sec7p family of proteins" /codon_start=1 /product="Mon2p" /protein_id="DAA10263.1" /db_xref="SGD:S000005241" /translation="MAMNTGGFDSMQRQLEAELRSLSSESKRRNSTIRHASDKSIEIL KRVHSFEELERHPDFALPFVLACQSRNAKMTTLAMQCLQGLSTVPSIPRSRLSEILDA FIEATHLAMEIQLKVLQVVPIFFKTYGKFIYGPLCKKLLLCCSNLLHVPNKAPVVVGT ASATLQQLIDEIFDRLSIESVVDDKQYEVLISNSESIKVNVYRYDANKLFDNICSLNE ISSNGAVSDEEMLLDIGDIPIDYGLEILESILKNSQKNLLECQDLQYLLRVKAIPLLL RCISSSRHFSTAVRSCRCLKLLIRKEYLSILELELEVILSLLIHGISVESNLSGWQRV LSLELFKDLSQDPEIVNTLYMDYDNYPDKKHVFKYLLKECIVLLNSPEYITFLAPSKV VEKMDSPLITTENSTVKTKFMHLLDKSNAPSINITYIISLILTICNHLCEGLNKSALE SSPLEKKIEDKEREEGTGNDSTVVKVYSGLFSGLFELNKLFLYSTSLETSIFHLVVRA FQKLAHSAGVLSLKDKLRACMKLFSILITNNVTSSNQYSFNDTSKSAKNQHTRNISTS SVTTSPVESTKNPSRSIADSAQNKEMKRRLHPRNISSRQVSLLRALISLSISLGPIFD SESWRYTFLTWQWITYYIYGPSADFKESFYSEDIPPPPILTKSDVTSIESSLTKFFES TSSYSCSTFHLVLTRLILDSKNTLTLEQTNLNLNNDIGYHPLDAKDEIIPCIYNKAFF VNKIGELATYNCKKFLFGKNGKELWSLISTYMIKLISNREMDNDSLRLYTVRVFTDII KKATNEVGNSDEQDNKVKQFGTLENLVIDSLMATINSIKQLDIGKQEIYNGTINVESD ILFQLLLTLKEILNEFGELLMNSWTNIFNIINSPFEWTVEDTDFSVNEDIDDSSLFEG IVQKHKNMIQVSYDVFKLISDDFLQSLPMSVIKFVIDTLVNFVSQKRNLNISFSSISQ FWLVGDYLRVRFNPETLNLSDEKRRSLSEKINNQKLIEIITSSSSHDWELYNGLWIYL LKNLINCTNDDRVEVKNGAVQTFFRIIDSHSVCFPPWDLIFLEVIEPLLTKEWSTEEL ENETDFINVTLQGLIKLYPEHFKDFKNNTTCAKEWSMLLDFLKRLLSSTSNNTKNAVI LNYQTLLKEIITIEDVPSDILKKCCEIFTDYNITYSDLSTNASSKTEYDCIYELITGF PPLYQLISKYDAMTDEFVEKVLLLFNSAIKYPLLPEFVQDKTKPSSMQKAILSGLDIF MTNDSKDTEILILLQLSTISILAFDTREKITKKLGPKLPKASLNRLPTFEAISYMSCS NLRNRIAKIDQFGISTLKAKHILRILKNLAEIIKRKSLITGSESDEIPIWVLASNCFC DLSNKIFKSLQEDAENPLKDNFCDLFINVIVVTLQRINPELDNLTEIDDLNEYSKYRE ILLENRIIDLFNERQLDTFIYAVWDCSFLYEFDELENALMQDCGTFSELSQKLSSFDF SCIFGSTTNPRFQTKYKCSLECLQDLVNFMLNTNEKLRKLTAPYLSARIALALRRYIS DEYLIGRAPIPKLRKTELATLLNGLCVILRGVLDQNSTLGNKQIGVENLQTLSPLILR TIPVSHKMDGLQDKVLELSLGFTKLD" gene 76946..78520 /gene="MRX6" /locus_tag="YNL295W" mRNA 76946..78520 /gene="MRX6" /locus_tag="YNL295W" /product="Mrx6p" CDS 76946..78520 /gene="MRX6" /locus_tag="YNL295W" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:31532710]" /experiment="EXISTENCE:mutant phenotype:GO:1901858 regulation of mitochondrial DNA metabolic process [PMID:31532710]" /note="Mitochondrial ribosome-associated protein; regulates mitochondrial DNA copy number and the size and distribution of mtDNA nucleoids; subunit of a complex containing Pet20p, Mam33p, and Pim1p that may regulate mtDNA replication; member of the PET20 domain-containing protein family; forms foci that partially co-localize with mtDNA" /codon_start=1 /product="Mrx6p" /protein_id="DAA10264.1" /db_xref="SGD:S000005239" /translation="MEHQALRRLVLYCPNFIRRGALRQNMTRVSCRHMSGKGGGRDEK GDCNEEKDSSKDLGRVPSKMKRAYDGETVIKEGDSHAESLAQQGKQPTDLAYNSRSKI SGSNLHLLVPRVASTDYISNKEVHTEGLFAGYRPLFLGNSGFPSDARKGKNFHELDDV LPNIQVVDASEKDGKLNVQEIIEDLQRTSLRESIHSMEQLPSSHKRKPVIPWDASISG MVYNDMPFKYVPKNIILKMKPFKLLRIERKSQAKNARKPTMIKLQFHNRRINDTPELV NLYHNKSRLHESLYNTKPLQESGYSSANTSKRQKMLKARSDFEHKQKNYAYKHTFIKN DQELFRNELTKLNKILAREFKKLTKLSIHNEFKREHLPLAVYVSKSKGTKKLFRRSLK MKIMDHIYPVYTTILSTLTNSRDSKKFENKIKAYIEKIIVRLSDEVPSTYFFQDGVDC IIQPSPIHNFKRMHWLRYTKRHNTFWGRTIHKDVQVSFNDKYVVTRSGVRYTRYPTNL NTQLLETAFEEWDYYE" gene complement(78659..80260) /gene="RIM21" /locus_tag="YNL294C" /gene_synonym="PAL2" mRNA complement(78659..80260) /gene="RIM21" /locus_tag="YNL294C" /gene_synonym="PAL2" /product="Rim21p" CDS complement(78659..80260) /gene="RIM21" /locus_tag="YNL294C" /gene_synonym="PAL2" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:23019326]" /experiment="EXISTENCE:genetic interaction:GO:0009272 fungal-type cell wall biogenesis [PMID:16524906]" /experiment="EXISTENCE:genetic interaction:GO:0044088 regulation of vacuole organization [PMID:25359886]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:10821185]" /experiment="EXISTENCE:mutant phenotype:GO:0009272 fungal-type cell wall biogenesis [PMID:16524906]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:10821185]" /experiment="EXISTENCE:mutant phenotype:GO:0071469 cellular response to alkaline pH [PMID:23019326]" /note="pH sensor molecule, component of RIM101 pathway; positive regulator of cell size; has role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH" /codon_start=1 /product="Rim21p" /protein_id="DAA10265.1" /db_xref="SGD:S000005238" /translation="MNLWRHSPEELAAYNSCHPMKLGSGVLIQLPLYDNSAVYAEDIT FRSFCCERVPVYVSTVLRNSSPYRYLDEVINDWQKFIQVSDYVGGSAEYAIYAVILSI TSNFVITVFLTVICCINISGRAYKRILQLLRIASLLASLNLTIFITKVLRRLEKEHNV YGVVRAHSIMHIFSDDMTFVVLDFLATLMFQFCQVGIVIRLFQRAQEKRIIFFIGVIL TITANILWVIPPFANHTTKHRNDWQILRPFVYLFRIAIATSYASIVIYHIWQKKKLWF KFNQMGLLTLLTILVVLLLPGFFLADVSNLWISELGEVFNTTCYVTSTVITWEWLDRL NVLERKEEAQSILGRPIFEEEQQDYRFAKYALRVQNALTRRESQDASTDRHDTSSNSE VCDLQTISRYDPEDQISVGRSIDRMHFNDRGTYKDVALKKLGYARDKILYFTDQIVQK SVGHNNSSSSKNEKTKQRKAMVRKRLGLDKPGIYIYSTKDVVFNSDEDDDENAEDEDD DEYEVGSEGNNNSSATFTSDHIGHI" gene 80640..82541 /gene="MSB3" /locus_tag="YNL293W" /gene_synonym="GYP3" mRNA 80640..82541 /gene="MSB3" /locus_tag="YNL293W" /gene_synonym="GYP3" /product="Rab GTPase-activating protein MSB3" CDS 80640..82541 /gene="MSB3" /locus_tag="YNL293W" /gene_synonym="GYP3" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:10679030]" /experiment="EXISTENCE:direct assay:GO:0000133 polarisome [PMID:16166638]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22593206]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:22593206|PMID:10559187]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:22593206]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22593206]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22593206]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:10679030|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22593206|PMID:26928762|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:35134079]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:12913108]" /experiment="EXISTENCE:genetic interaction:GO:0070649 formin-nucleated actin cable assembly [PMID:16166638]" /experiment="EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:22593206]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:22593206]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:22593206]" /experiment="EXISTENCE:physical interaction:GO:0006897 endocytosis [PMID:22593206]" /experiment="EXISTENCE:physical interaction:GO:0032880 regulation of protein localization [PMID:22593206]" /experiment="EXISTENCE:physical interaction:GO:0070649 formin-nucleated actin cable assembly [PMID:16166638]" /note="Rab GTPase-activating protein; regulates endocytosis via inactivation of Vps21p at endosomes and vacuole fusion via inactivation of Ypt7p at vacuoles; also acts on Ypt52p and Sec4p; localizes to plasma membrane, sites of polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; similar to TBC-domain Tre2 oncogene; MSB3 has a paralog, MSB4, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null" /codon_start=1 /product="Rab GTPase-activating protein MSB3" /protein_id="DAA10266.1" /db_xref="SGD:S000005237" /translation="MQNDQQRFSLQNRTVLAHPYKRLGGAFTVKSPSVPNFHDKMHSD HSSSDSALVNGSFRANDHRSVEPSCLGQASPSEHDGNLSVIDLYGDEVESQRAEGEDD DDNNGDNGNEDLEEVHSDDLDLVPDDDNRQRVELEGAASATSANSNGINNTHFDRYGF KKQNNYISEAEYDKWWVEYSQYCVRRKHKWQLLLEKSGLPVTDDSPSRFPSKSERLKR YVRKGIPAEWRGNAWWHFARGQEKLNKNKGVYSQLLRKMKQIKKQNPNEKQVQDLDII ERDLNRTFPDNIHFQSSLHNKEGPPIIKSLRRVLVAFSLYNPKIGYCQSMNFLAGLLL LFLDEERAFWMLVIITSRYLPGVHNINLEGVNIDQGVLMLCVKEYIPEVWSYIKPSID HHQKNNKTFSPSNKKVLFNMQKNEFLYRLPPITLCTASWFMSCFVGVVPIETTLRIWD CLFYEESHFLFKVSLAVLKLSEHDLSKIKPRNNSLNYSWGSNLNQRGGSMGQEDSDME IFQVIQTFPKTLLNPNEIFEKIIFKRRFNLNRLDQDEIDRCRKFVAAQRLKFKTYGEL LGNSTSEADLPINDNTDNKGIHITSDAVNEALSSEVYGFKKSLAGVHWNNSIKEKVKQ MRKKKDKGD" gene 82806..84017 /gene="PUS4" /locus_tag="YNL292W" mRNA 82806..84017 /gene="PUS4" /locus_tag="YNL292W" /product="pseudouridine synthase PUS4" CDS 82806..84017 /gene="PUS4" /locus_tag="YNL292W" /EC_number="5.4.99.25" /experiment="EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:9358157]" /experiment="EXISTENCE:direct assay:GO:0009982 pseudouridine synthase activity [PMID:9358157]" /experiment="EXISTENCE:genetic interaction:GO:0009982 pseudouridine synthase activity [PMID:9358157]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:9358157]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:9358157]" /experiment="EXISTENCE:mutant phenotype:GO:1990481 mRNA pseudouridine synthesis [PMID:25192136|PMID:25219674]" /note="Pseudouridine synthase; catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; also responsible for pseudouracil modification of some mRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)" /codon_start=1 /product="pseudouridine synthase PUS4" /protein_id="DAA10267.1" /db_xref="SGD:S000005236" /translation="MNGIFAIEKPSGITSNQFMLKLQHALTKSQVFSKEIQRATAERK QQYEKQTGKKASKRKLRKVSKVKMGHGGTLDPLASGVLVIGIGAGTKKLANYLSGTVK VYESEALFGVSTTSGDVEGEILSQNSVKHLNFDDLKTVEEKFVGQLKQTPPIYAALKM DGKPLHEYAREGKPLPRAIEPRQVTIYDLKVFSDSLKRDHDYPLLRPTTEEAVDTVKN LNANMLNDVLYFSKEYTEKHGLDSEVAKVEEPFPLSEQEEQEIQKEGDSYRAPKLHFK ANVSSGTYIRSLVSDIGKSMRSSCYMVKLIRLQQQDWSLEKNNVFQLTDFTERDEKVW SKVLEKVLDEGATVDVIEELKKAEKEIPADVKECIVSSDQPGDEATAETIETANAEEH SNTLKRKIEQV" gene complement(84169..85815) /gene="MID1" /locus_tag="YNL291C" mRNA complement(84169..85815) /gene="MID1" /locus_tag="YNL291C" /product="Mid1p" CDS complement(84169..85815) /gene="MID1" /locus_tag="YNL291C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14729456]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10958666]" /experiment="EXISTENCE:direct assay:GO:0006816 calcium ion transport [PMID:10958666]" /experiment="EXISTENCE:direct assay:GO:0015275 stretch-activated, monoatomic cation-selective, calcium channel activity [PMID:10436155]" /experiment="EXISTENCE:mutant phenotype:GO:0005262 calcium channel activity [PMID:12492866|PMID:9343395]" /note="Stretch-activated Ca2+-permeable cation channel; required for Ca2+ influx stimulated by mating pheromones and some abiotic stresses; sensor of compressive mechanical stress; N-glycosylated membrane protein of the ER and plasma membrane; interacts with Cch1p; oligomerizes; is an alpha2/delta-like protein and participates in the generation of stretch-activated Ca2+-permeable cation channel activity when expressed in mammalian cells" /codon_start=1 /product="Mid1p" /protein_id="DAA10268.1" /db_xref="SGD:S000005235" /translation="MIVWQALFVVYCLFTTSIHGLFQDFNPFANKNISLKFPSLNRWE KNVMATGQQTIINSDSIYEWTPILSNITAGKKDSFVFTIDAEASGYGFAPTYEVLMFI SGNICQMPMNRSDVDLTIYYSFNETVLENPNIGQSAVFQDGYIQALAISPVQSSSSNA TSTYSNLYVVAELVNSTTEQPLSSSDASENWEYRLSISENDLVFQWDVRPWVEVLDTD MNSALLSTGNVTADAKVYHNYSIYDPSLYDLYVYSYEDSVQLNQNYNLSLCAVKNGPY LVSSQNTSNATVTSNSTNPLERTDLAIQKKITEYGGSVTEMFYVTGLNASTTYVAYLT KKISNGDGLSSVGGILFSHVYFTTRSTDVCSLIFGLDFCSDVAYSVPTSSFSVGNKTL MAQTYDHIAEALYANFSKALQLISCDADKDARYSPVMTCDDCAEAYRDWVCAVSIPRC TTTSSQYYIHRDKSHNRNDYLNKFIKPLDDYYEILPCIDMCYTLVRNCPSDFQFSCPN DLTTEDLLYQSYNFYMDTDYSTCNYIGNSSLMVIHPLDDT" gene 86218..87240 /gene="RFC3" /locus_tag="YNL290W" mRNA 86218..87240 /gene="RFC3" /locus_tag="YNL290W" /product="replication factor C subunit 3" CDS 86218..87240 /gene="RFC3" /locus_tag="YNL290W" /experiment="EXISTENCE:direct assay:GO:0003689 DNA clamp loader activity [PMID:8995429|PMID:12604797]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005663 DNA replication factor C complex [PMID:7651383]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006272 leading strand elongation [PMID:1346062]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:8302859]" /experiment="EXISTENCE:direct assay:GO:0031389 Rad17 RFC-like complex [PMID:12604797|PMID:10660302]" /experiment="EXISTENCE:physical interaction:GO:0031389 Rad17 RFC-like complex [PMID:10660302]" /experiment="EXISTENCE:physical interaction:GO:0031390 Ctf18 RFC-like complex [PMID:11389843]" /experiment="EXISTENCE:physical interaction:GO:0031391 Elg1 RFC-like complex [PMID:12912927]" /note="Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia" /codon_start=1 /product="replication factor C subunit 3" /protein_id="DAA10269.1" /db_xref="SGD:S000005234" /translation="MSTSTEKRSKENLPWVEKYRPETLDEVYGQNEVITTVRKFVDEG KLPHLLFYGPPGTGKTSTIVALAREIYGKNYSNMVLELNASDDRGIDVVRNQIKDFAS TRQIFSKGFKLIILDEADAMTNAAQNALRRVIERYTKNTRFCVLANYAHKLTPALLSR CTRFRFQPLPQEAIERRIANVLVHEKLKLSPNAEKALIELSNGDMRRVLNVLQSCKAT LDNPDEDEISDDVIYECCGAPRPSDLKAVLKSILEDDWGTAHYTLNKVRSAKGLALID LIEGIVKILEDYELQNEETRVHLLTKLADIEYSISKGGNDQIQGSAVIGAIKASFENE TVKANV" gene 87897..88736 /gene="PCL1" /locus_tag="YNL289W" /gene_synonym="HCS26" mRNA 87897..88736 /gene="PCL1" /locus_tag="YNL289W" /gene_synonym="HCS26" /product="Pcl1p" CDS 87897..88736 /gene="PCL1" /locus_tag="YNL289W" /gene_synonym="HCS26" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:14688790]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14688790]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:7973730]" /experiment="EXISTENCE:genetic interaction:GO:0031106 septin ring organization [PMID:19458192]" /experiment="EXISTENCE:genetic interaction:GO:0032878 regulation of establishment or maintenance of cell polarity [PMID:17853895]" /experiment="EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:20417603]" /experiment="EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:7973730]" /experiment="EXISTENCE:physical interaction:GO:0032878 regulation of establishment or maintenance of cell polarity [PMID:17853895]" /note="Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth" /codon_start=1 /product="Pcl1p" /protein_id="DAA10270.1" /db_xref="SGD:S000005233" /translation="MCEYSKALHILLKSPVTDDIIKFLTDTTLRVVPSSNYPTPPGSP GEKHLTRLPSLMTFITRLVRYTNVYTPTLLTAACYLNKLKRILPRDATGLPSTIHRIF LACLILSAKFHNDSSPLNKHWARYTDGLFTLEDINLMERQLLQLLNWDLRVNTEDLIL DLQPLLEPIKQDLARSSDQRKRINMMMSMNRRTCAGTSPIRSNNRFKLYEKQRNVSIA SDLSSATLVDSCNDLRRLKDVTNIANNTVANTNYVRTVEKWNDNVNRQSWDLEQIMSQ HGF" gene 89210..89306 /gene="SNR40" /locus_tag="YNCN0001W" ncRNA 89210..89306 /ncRNA_class="snoRNA" /gene="SNR40" /locus_tag="YNCN0001W" /product="SNR40" /experiment="EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243|PMID:8674114]" /experiment="EXISTENCE:curator inference:GO:0031428 box C/D methylation guide snoRNP complex [PMID:8674114|PMID:10024243]" /experiment="EXISTENCE:direct assay:GO:0000452 snoRNA guided rRNA 2'-O-methylation [PMID:25653162]" /experiment="EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]" /experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]" /note="C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position U898 and small subunit (SSU) rRNA at position G1271" /db_xref="SGD:S000007304" rep_origin 89531..89804 /note="ARS1407; Autonomously Replicating Sequence" /db_xref="SGD:S000118384" gene 90303..91424 /gene="CAF40" /locus_tag="YNL288W" mRNA 90303..91424 /gene="CAF40" /locus_tag="YNL288W" /product="CCR4-NOT core subunit CAF40" CDS 90303..91424 /gene="CAF40" /locus_tag="YNL288W" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:21406554]" /experiment="EXISTENCE:physical interaction:GO:0030015 CCR4-NOT core complex [PMID:11733989]" /note="Component of the CCR4-NOT transcriptional complex; evolutionarily conserved; involved in controlling mRNA initiation, elongation, and degradation; binds Cdc39p" /codon_start=1 /product="CCR4-NOT core subunit CAF40" /protein_id="DAA10271.1" /db_xref="SGD:S000005232" /translation="MFSAQKPIYGNGAGVNMGGGGPSTNNPGSMSMPGVPTSMGPGMN QQIPSGGPMLMGNTPNNNNSNENGENNGNNGNNGGNDANATRNNPNMVNNRGAVHALD DPNVYHWICQLTYGPQKEQALLELGRKREQFDDLAVVLWSSFGVMTSLLNEIISVYPM LQPQMLSNNLSNRVCNALVLLQCVASHPETKHLFLQAHIPLFLFPFLNTTSRQRTFEY LRLTSLGVIGALVKNDSQDVITFLLRTDIVPLCLRIMESSSELSKTVAIFILQKILLD DVGLQYICATLERFYAVTNVLKDMVEHLTVSTPPGRLLKHIIRCYLRLSDDLEARRLL KIVLPAKLRDNTFTEVLRDDVGSKRCLAQLLLTLNEETS" gene 91994..94801 /gene="SEC21" /locus_tag="YNL287W" mRNA 91994..94801 /gene="SEC21" /locus_tag="YNL287W" /product="coatomer subunit gamma" CDS 91994..94801 /gene="SEC21" /locus_tag="YNL287W" /experiment="EXISTENCE:direct assay:GO:0030126 COPI vesicle coat [PMID:1461285]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:1461285]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:8001155]" /note="Gamma subunit of coatomer; coatomer is a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo" /codon_start=1 /product="coatomer subunit gamma" /protein_id="DAA10272.1" /db_xref="SGD:S000005231" /translation="MSAHTYKKFENSTSGDLPDKMTIYQDCMNTFNESPVNSKRCRLL ISRLLRLLAQGETFPQNEATALFFSISKLFQHQNDPLRQAVYLAIKELSGISEDVLMA TSSIMKDVQNGSDLIKPDAIRSLTYVLDESTAFSAERLLKSAVVSRHPSISSAALCTS YHLLPISEVTIRRFTNETQEAVLDLKQFPNQHGNSEYYPNSTYISQYHALGLLYQLKK TDKMALLKLVRHFSENNSMKNQLAKVELVKIVNDLIYRDPQLFSQFRPLLSDWLSNKF ESVQLETAKLITSFATRNSRLVAPELYAAAISALQSLLTVPRVSSRFAALRILNRISM VSPEKIVVCNPELESLINDSNRNISTYAITTLLKTGTSKNISSLISTITNFIHDVSDD FKIIIIDAVRTLSLNFPQEWKSILNFLIDVLKNSEGGFKFKNSIVEALIDIVSFVPQS KELALENLCDFIEDCEFNEILVRILHLLGKEGPSAPNPSLYVRHIYNRVVLENSIIRS AAVVALSKFALTKNDPTLYESIISLLKRIANDKDDEVRDRATIALEFIDSARNKDDVI AQNLIESKYFYDIPSLESKLSSYISSNTDSFATAFDVNQVRKFTEDEMKAINLKRKQE QIFNQKSETTLDTTPEAESVPEKRADANSFAGPNLDDHQEDLLATKYADELLSIEQIK PFGQLVNSSRAISLTEPEAEFVVRGVKHLFKDNVVLQFNITNTLTDIALDNVSVVCTP EISDEAELEELFTLQVDRLLPSEEAACYVAFKKLDEIVMEGFLNNLTFTTKEINPDTN EPFDGDEGFQDEYEIDSIFLNAGDYVKSSFTGNFSATFDELPCEEVAVFNIQEDLSIQ EVVDKIILNSSCLPVESTQFAPSDSNSHTLKLFGKSALTGSKVALQIKMIKSSKGLAL KVHGKGEDSLLCSDLVNGLMQ" gene 95223..96080 /gene="CUS2" /locus_tag="YNL286W" mRNA 95223..96080 /gene="CUS2" /locus_tag="YNL286W" /product="U2 snRNP complex subunit CUS2" CDS 95223..96080 /gene="CUS2" /locus_tag="YNL286W" /experiment="EXISTENCE:direct assay:GO:0030620 U2 snRNA binding [PMID:26631165]" /experiment="EXISTENCE:direct assay:GO:0034337 RNA folding [PMID:26631165]" /experiment="EXISTENCE:genetic interaction:GO:1903241 U2-type prespliceosome assembly [PMID:9710584]" /experiment="EXISTENCE:mutant phenotype:GO:0030620 U2 snRNA binding [PMID:26631165|PMID:9710584]" /experiment="EXISTENCE:mutant phenotype:GO:0034337 RNA folding [PMID:26631165]" /experiment="EXISTENCE:physical interaction:GO:0005686 U2 snRNP [PMID:26631165]" /experiment="EXISTENCE:physical interaction:GO:1903241 U2-type prespliceosome assembly [PMID:9710584]" /note="Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; regulates toggling of the U2 snRNA stem II region between different structures; contains two RNA recognition motifs (RRMs)" /codon_start=1 /product="U2 snRNP complex subunit CUS2" /protein_id="DAA10273.1" /db_xref="SGD:S000005230" /translation="MDADELELKGHLKKLKKEELLRRKQLKESNLQKRELEYNNASKN TSIYISGLPTDKTTKEGLTEQFCKYGMIRTNRDGEPLCKLYVNDKGAFKGDALITYSK EESVTLAIEMMNESIFLGKQIRVERAQFQNKEGDNMHGKENDLKEFNGPEPPIKRLKK AKSEGEGEVIDYNDDESLAKADRTVIFANVFNIYKSYTNDDINDIQEDLLEGCEEIGQ VDSISVSPNKGEATVVFKNNKVALQCCKIMTGRYFDGQKLLAFISGDENTSSTSDKNE DSEVEDDLI" gene complement(96241..96312) /gene="SUF6" /locus_tag="YNCN0002C" tRNA complement(96241..96312) /gene="SUF6" /locus_tag="YNCN0002C" /product="tRNA-Gly" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Glycine tRNA (tRNA-Gly), predicted by tRNAscan-SE analysis; can mutate to suppress +1 frameshift mutations in glycine codons" /db_xref="SGD:S000006591" rep_origin 96247..96463 /note="ARS1409; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay" /db_xref="SGD:S000130140" repeat_region 96451..96609 /note="Ty4 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007140" mobile_element complement(96610..102523) /note="YNLCTy1-1; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats" /mobile_element_type="retrotransposon:YNLCTy1-1" /db_xref="SGD:S000007134" repeat_region complement(96610..96941) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007129" gene complement(96964..102232) /locus_tag="YNL284C-B" mRNA complement(96964..102232) /locus_tag="YNL284C-B" /product="gag-pol fusion protein" CDS complement(join(96964..100926,100928..102232)) /locus_tag="YNL284C-B" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /codon_start=1 /product="gag-pol fusion protein" /protein_id="DAA10274.1" /db_xref="SGD:S000007387" /translation="MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKIQEYD KASTKANSQQTTTPASSAVPENPHHASPQTAQSHSPQNGPYQQQCMMTQNQANPSGWS FYGRPSMIPYTPYQMSPMYFPPGPHSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS DMTSTKKYVRPPPMLTSPNDFLNWVKTYIKFLQNSNLGDIIPTATRKAVRQMTDDELT FLCHTFQLFAPSQFLPTWVKDILSADYTDIMKILSKSINKMQSDTQEVNDITTLATLH YNGSTPADAFEAEVTNILDRLNNNGIPINNKVACQFIMRGLSGEYKFLRYARHRYIHM TVADLFSDIHSMYEEQQESKRNKSTYRRNPSDEKKDSRTYTNTTKPKSITRNSQKPNN SQSRTARAHNVSTSNNSSGPDNDLIRGSTTEPIQLKNKHDLHLGQELTESTVNHTNHS DDELPGHLLLDSGASRTLIRSAHHIHSASSNPGINVVDAQKRNIPINAIGDLQFHFQD NTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWV SKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNE SDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKS APSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSE YTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFS AIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGI PGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLT ASYQSFIASNEIQQSDDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTE DSKRVSKTNIRAPREVDPNISKSNILPSKKRSSTPQISDIESTGSGGMHRLDVPLLAP MSQYNTHESSHTSKSKDFRHSDSYSDNETNHTNVPISSTGGTNNKTVPQTSEQETEKR IIHRSPSIDTSSSESNSLHHVVPIKTSDTCPKENTEESIIADLPLPDLPPEPPTKLSD SFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSL EPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLL KMKTWDTDRYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQS NTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLK KSLYGLKQSGANWYETIKSYLIQQCGMEEVRGWSCVFKNSQVTICLFVDDMVLFSKNL NSNKRIIEKLKMQYDTKIINLGESDEEIQYDILGLEIKYQRGKYMKLGMENSLTEKIP KLNVPLNPKGRKLSAPGQPGLYIDQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRF DLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISD ASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSY LIQELDKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCY IETKKNIADVMTKPLPIKTFKLLTNKWIH" gene complement(100910..102232) /locus_tag="YNL284C-A" mRNA complement(100910..102232) /locus_tag="YNL284C-A" /product="gag protein" CDS complement(100910..102232) /locus_tag="YNL284C-A" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /codon_start=1 /product="gag protein" /protein_id="DAA10275.1" /db_xref="SGD:S000007386" /translation="MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKIQEYD KASTKANSQQTTTPASSAVPENPHHASPQTAQSHSPQNGPYQQQCMMTQNQANPSGWS FYGRPSMIPYTPYQMSPMYFPPGPHSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS DMTSTKKYVRPPPMLTSPNDFLNWVKTYIKFLQNSNLGDIIPTATRKAVRQMTDDELT FLCHTFQLFAPSQFLPTWVKDILSADYTDIMKILSKSINKMQSDTQEVNDITTLATLH YNGSTPADAFEAEVTNILDRLNNNGIPINNKVACQFIMRGLSGEYKFLRYARHRYIHM TVADLFSDIHSMYEEQQESKRNKSTYRRNPSDEKKDSRTYTNTTKPKSITRNSQKPNN SQSRTARAHNVSTSNNSSGPDNDLIRGSTTEPIQLKNKHDLHLRPGTY" repeat_region complement(102192..102523) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007130" repeat_region complement(102632..102700) /note="Ty3 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007133" gene 102716..102789 /locus_tag="YNCN0003W" tRNA 102716..102789 /locus_tag="YNCN0003W" /product="tRNA-Asn" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Asparagine tRNA (tRNA-Asn), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006673" gene complement(103134..104102) /gene="MRPL10" /locus_tag="YNL284C" /gene_synonym="MRPL18" /gene_synonym="uL15m" mRNA complement(103134..104102) /gene="MRPL10" /locus_tag="YNL284C" /gene_synonym="MRPL18" /gene_synonym="uL15m" /product="mitochondrial 54S ribosomal protein YmL10/YmL18" CDS complement(103134..104102) /gene="MRPL10" /locus_tag="YNL284C" /gene_synonym="MRPL18" /gene_synonym="uL15m" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978]" /note="Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels" /codon_start=1 /product="mitochondrial 54S ribosomal protein uL15m MRPL10" /protein_id="DAA10276.1" /db_xref="SGD:S000005228" /translation="MKAERQTGLRNSFTTVIGRKLINTFVPSMMLTSVAGNDIFFRGL FKSPVLAFQSYRYVSILGQLKPSDGSTKSFKRLGRGPSSGLGKTSGRGQKGQKARGKV KSWFEGGQTPIYKLFPKIGFTNVGAKPLKELNLKRIQWFHDKNRLHLQPGEVLDMNKM RKLGLVTGPIKYGVKILASGKFHYNLPIALEASRASAKAIAAIEKAGGKFTARYYTPL GLRAHLNPQWFLEKRGRVPLQARPTKRRDIDFYSKEEKRGYLVMEKDKLLQDIKEAQN KGSRHFLKQNVKKSSLEIELEELSPEKDWVPVVSNSKVMNIKALDH" gene 104805..104877 /locus_tag="YNCN0004W" tRNA 104805..104877 /locus_tag="YNCN0004W" /product="tRNA-Thr" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Threonine tRNA (tRNA-Thr), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006744" gene complement(105184..106695) /gene="WSC2" /locus_tag="YNL283C" /gene_synonym="STA3" mRNA complement(105184..106695) /gene="WSC2" /locus_tag="YNL283C" /gene_synonym="STA3" /product="Wsc2p" CDS complement(105184..106695) /gene="WSC2" /locus_tag="YNL283C" /gene_synonym="STA3" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:27337501|PMID:20652590]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:20652590|PMID:13679573]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:20652590]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:11545731]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:mutant phenotype:GO:0004888 transmembrane signaling receptor activity [PMID:10430578]" /experiment="EXISTENCE:mutant phenotype:GO:0007266 Rho protein signal transduction [PMID:10348843]" /experiment="EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:10348843]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10348843]" /note="Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity and recovery from heat shock; required for the arrest of secretion response; WSC2 has a paralog, WSC3, that arose from the whole genome duplication" /codon_start=1 /product="Wsc2p" /protein_id="DAA10277.1" /db_xref="SGD:S000005227" /translation="MHLDLIHKSFILVWLIYIRAALADQFTYKACYSASDIRKLGLTY KGVYEYQSVSYCQNECPGQAVVALFNGTGCYCGGSVAQLQSLTQVDSSKCDVSCAGWP YQNCGGSSAMNVYINNAASTADSTSSTATSTSTTSSSSTSVSSKTSTKLDTKTSTSSS ATHSSSSSSTTSTTTSSSETTTSSSSSSSSSSTSTTSTTSTTSSTTSTSSSPSTTSSS TSASSSSETSSTQATSSSTTSTSSSTSTATVTSTPSSTSIGTSTHYTTRVVTQSVVSQ ANQQASTIFTTRTSVYATVSSTSSSTSSLLNGKSSSSKSKGLSGGAIAGVVVGVVCGT VALLALALFFFVWKKRRQSSQHVDLEETKQYQPYSLGDADANPVIPPSASSTNWHIPS RNNTALSKNTASTFATYDLPTRAPGGRDSIITGDAHNISKRSHFPSVVYEEPPSIYNG NQRFSATSLPDMMEERQLHIVNPDNVSSNIGSNVSDGDDDYDDAKDSNNSSLR" gene 107687..108274 /gene="POP3" /locus_tag="YNL282W" mRNA 107687..108274 /gene="POP3" /locus_tag="YNL282W" /product="Pop3p" CDS 107687..108274 /gene="POP3" /locus_tag="YNL282W" /experiment="EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent [PMID:14729943]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005655 nucleolar ribonuclease P complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0034965 intronic box C/D snoRNA processing [PMID:18713869]" /experiment="EXISTENCE:mutant phenotype:GO:0000171 ribonuclease MRP activity [PMID:9029160]" /experiment="EXISTENCE:mutant phenotype:GO:0004526 ribonuclease P activity [PMID:9029160]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9029160]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:9029160]" /experiment="EXISTENCE:physical interaction:GO:0000172 ribonuclease MRP complex [PMID:17881380|PMID:9029160]" /experiment="EXISTENCE:physical interaction:GO:0005655 nucleolar ribonuclease P complex [PMID:9029160]" /note="Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; increases the activity and thermal stability of the RNase P complex, along with Pop2p; relocalizes to the cytosol in response to hypoxia" /codon_start=1 /product="Pop3p" /protein_id="DAA10278.1" /db_xref="SGD:S000005226" /translation="MSGSLKSLDKKIAKRRQVYKPVLDNPFTNEAHMWPRVHDQPLIW QLLQSSIINKLIHIQSKENYPWELYTDFNEIVQYLSGAHGNSDPVCLFVCNKDPDVPL VLLQQIPLLCYMAPMTVKLVQLPKSAMDTFKSVSKYGMLLLRCDDRVDKKFVSQIQKN VDLLQFPWLNAIKYRPTSVKLLKTTVPIVSKKRQK" gene 108467..108928 /gene="HCH1" /locus_tag="YNL281W" mRNA 108467..108928 /gene="HCH1" /locus_tag="YNL281W" /product="Hch1p" CDS 108467..108928 /gene="HCH1" /locus_tag="YNL281W" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:12504007]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0051087 protein-folding chaperone binding [PMID:12504007]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:12504007]" /experiment="EXISTENCE:physical interaction:GO:0006457 protein folding [PMID:12504007]" /note="Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; role in regulating Hsp90 inhibitor drug sensitivity; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="Hch1p" /protein_id="DAA10279.1" /db_xref="SGD:S000005225" /translation="MVVLNPNNWHWVDKNTLPWSKDYLNGKLTSLSTVSSDGKSKIEL TQVSSITGDSNVSQRKGKPICYFDLQLSMNVKVTNLDTNKDDEDDDGILADGKLEIPE FMHDESDIPILSQGFDAFDGLVRSEFVPKVVETLLKYQDDLIKEHSKDIQV" gene complement(109095..110411) /gene="ERG24" /locus_tag="YNL280C" mRNA complement(109095..110411) /gene="ERG24" /locus_tag="YNL280C" /product="delta(14)-sterol reductase" CDS complement(109095..110411) /gene="ERG24" /locus_tag="YNL280C" /EC_number="1.3.1.70" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0050613 Delta14-sterol reductase activity [PMID:32908]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:8125337|PMID:1394506|PMID:1418625]" /experiment="EXISTENCE:mutant phenotype:GO:0050613 Delta14-sterol reductase activity [PMID:8125337|PMID:1394506]" /note="C-14 sterol reductase; acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions" /codon_start=1 /product="delta(14)-sterol reductase" /protein_id="DAA10280.1" /db_xref="SGD:S000005224" /translation="MVSALNPRTTEFEFGGLIGALGISIGLPVFTIILNQMIRPDYFI KGFFQNFDIVELWNGIKPLRYYLGNRELWTVYCLWYGILAVLDVILPGRVMKGVQLRD GSKLSYKINGIAMSTTLVLVLAIRWKLTDGQLPELQYLYENHVSLCIISILFSFFLAT YCYVASFIPLIFKKNGNGKREKILALGGNSGNIIYDWFIGRELNPRLGPLDIKMFSEL RPGMLLWLLINLSCLHHHYLKTGKINDALVLVNFLQGFYIFDGVLNEEGVLTMMDITT DGFGFMLAFGDLSLVPFTYSLQARYLSVSPVELGWVKVVGILAIMFLGFHIFHSANKQ KSEFRQGKLENLKSIQTKRGTKLLCDGWWAKSQHINYFGDWLISLSWCLATWFQTPLT YYYSLYFATLLLHRQQRDEHKCRLKYGENWEEYERKVPYKIIPYVY" gene 110917..112902 /gene="PRM1" /locus_tag="YNL279W" mRNA 110917..112902 /gene="PRM1" /locus_tag="YNL279W" /product="pheromone-regulated protein PRM1" CDS 110917..112902 /gene="PRM1" /locus_tag="YNL279W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:11062271]" /experiment="EXISTENCE:mutant phenotype:GO:0032220 plasma membrane fusion involved in cytogamy [PMID:11062271|PMID:15590839]" /note="Pheromone-regulated multispanning membrane protein; involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p" /codon_start=1 /product="pheromone-regulated protein PRM1" /protein_id="DAA10281.1" /db_xref="SGD:S000005223" /translation="MSGFKCYLQLGDRLSQIWLNKYTLVLLLAMLKLLFFSKSIQHAI EVSETYILSNCYSIDSLYSKMTDNTPHYLGIMGNYLIEKGMEETVKATLETLSLIVYA SEGLVNFAIDLYLGTYACLIVSAVDGTVDVATNITEKLISLVNDTVSSVANELDTGLN DISKIINKVIKAASKVENFFTGDDDDSNMTSSIKSVNLTISALHNLYIPSSINDKLEE LSAKTPDFAQVKNTTKNLISVPFNEVRKNIKAVNASNIIGDTSVLYVPPVSLDNSTGI CSSNQSEILAFYSILGHVLKIATVVCITVLICFAVGAMAPVAWNEIKLWRRLCGMRDH YMLSRQDSYTSFSSENTHELKDPFRDPPIQNGQYDVIASYQQCFQTWNTRIAGWMTNL VTFGKSPENIDPKTKQKIEWVVAYMTSERALCVLGIGLLGILVCICQFVMIALLKHKI SHSLTSNDGDGVQNLLKSSTAVDIENQMSLWSVQTNKYINTTETNINQEVFGWINTTT LSVNNTVATMISDIDTTLADVFNGTLLYNPMKTVVGCAIENKLYTIEKAMTWIHDKAQ LHIPRINGTQIKQALAKQTDNSTIPTASSTSAATENLLENLVNDMREGLLKILRAYHR ITLGELTVALVILAVWLVQLPIALVILRLRLRKATFD" gene 113271..116453 /gene="CAF120" /locus_tag="YNL278W" mRNA 113271..116453 /gene="CAF120" /locus_tag="YNL278W" /product="Caf120p" CDS 113271..116453 /gene="CAF120" /locus_tag="YNL278W" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:25028499]" /note="Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; contains a PH-like domain; CAF120 has a paralog, SKG3, that arose from the whole genome duplication" /codon_start=1 /product="Caf120p" /protein_id="DAA10282.1" /db_xref="SGD:S000005222" /translation="MRIFSGDNKVVDSLASNPGLMSPSNFGGDFGSRLKVNVTSKKKL NDSSPTSPMESSPVSPELVPILTLLNAHTHRRYHEGVFLILQDLNNNGTHAARKWKDV YGVLLGTQLALWDAKELAEFTDPSCPVSEKKLKEVASKPTYINLTDATLRTLDNSDNI VMECGKNLTNALVVSTTLKNRYFLQFGNKESFNAWNSAIRLCLYECSSLQEAYTGAFI SSRGAKLGDIRILLTNRKYDYKDWVSVRFGAGMPWKRCYAVISQSSSKKKGHFGEINL YENDKKVKKNHAMATIVEAKALYAVYPSSPKLIDSSTIIKVVGSVKFEKKESAQEKDV FIMPEKHQAVPSYDTIIRFLIPAMDTFKLYGRPEKLLSSKNDPHSLLFGLPVLPHIYY LEVEDLLPLTNSVSSLHWSNNEWKEHISDILQRKIAQGYCGCNSTSNITSPLPSPFLG SADLFERADGVLSPKLSYGSKSSSNNSSKNSLPKRERVKLSSSSEQDLNNSDSPSIKR KSPPLVISESPHKVHTPTDASFRTRVTEGSPYAKQRHPKPFASSVNDSPSDRAKSRTV PYNNNDRKATTPEKFERGETSCGKNVDESLEKVRNMKLEIPESNFDKFMTDKNLLSVD SKCSNEKKLSVESDLSAIYEKYSNGPFGHTEGLNGSSDETYLRFQRASVHSESNYNSR KSFTPSDFSNGNEEEHAVLQELNSLTQRINELGMESINSNSDSDRINGSYSQVDFGNN NDEDDMNLFDPDFMAQDQLRAEERDYNKDDRTPLAKVPAAFQSTGLGITPDDDIERQY ITEHRSRHEVPKRSPEKPSNPLEIGNPYAKPGTRLNTTHTHSKTDRSITPQRGQPVPS GQQISSYVQPANINSPNKMYGANNSAMGSPRNPKTRAPPGPYNQGWNNRPSPSNIYQR PHPSDTQPQAYHLPGNPYSTGNRPNMQAQYHPQQVPMPILQQPNRPYQPYAMNTHMGS PGGYAGAAPPFQPANVNYNTRPQQPWPTPNSPSAHYRPPPNLNQPQNGSAGYYRPPAP QLQNSQARPQKKDGFSQFMPSATTKNPYAQ" gene 116679..116867 /locus_tag="YNL277W-A" mRNA 116679..116867 /locus_tag="YNL277W-A" /product="hypothetical protein" CDS 116679..116867 /locus_tag="YNL277W-A" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10283.1" /db_xref="SGD:S000028852" /translation="MTLAYYGQPVKMCHILPPLRSLPVLVGKKKLKKKKSQTTNNHVI FLFTLFIKLLKTHNRMSL" gene 117349..118809 /gene="MET2" /locus_tag="YNL277W" mRNA 117349..118809 /gene="MET2" /locus_tag="YNL277W" /product="homoserine O-acetyltransferase" CDS 117349..118809 /gene="MET2" /locus_tag="YNL277W" /EC_number="2.3.1.31" /experiment="EXISTENCE:direct assay:GO:0004414 homoserine O-acetyltransferase activity [PMID:3301801]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0009092 homoserine metabolic process [PMID:3301801]" /experiment="EXISTENCE:mutant phenotype:GO:0000096 sulfur amino acid metabolic process [PMID:1101032]" /experiment="EXISTENCE:mutant phenotype:GO:0004414 homoserine O-acetyltransferase activity [PMID:3301801]" /experiment="EXISTENCE:mutant phenotype:GO:0009086 methionine biosynthetic process [PMID:6035500]" /experiment="EXISTENCE:mutant phenotype:GO:0009092 homoserine metabolic process [PMID:3301801]" /note="L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway" /codon_start=1 /product="homoserine O-acetyltransferase" /protein_id="DAA10284.1" /db_xref="SGD:S000005221" /translation="MSHTLKSKTLQELDIEEIKETNPLLKLVQGQRIVQVPELVLESG VVINNFPIAYKTWGTLNEAGDNVLVICHALTGSADVADWWGPLLGNDLAFDPSRFFII CLNSMGSPYGSFSPLTINEETGVRYGPEFPLCTVRDDVRAHRIVLDSLGVKSIACVIG GSMGGMLSLEWAAMYGKEYVKNMVALATSARHSAWCISWSEAQRQSIYSDPNYLDGYY PVEEQPVAGLSAARMSALLTYRTRNSFENKFSRRSPSIAQQQKAQREETRKPSTVSEH SLQIHNDGYKTKASTAIAGISGQKGQSVVSTASSSDSLNSSTSMTSVSSVTGEVKDIK PAQTYFSAQSYLRYQGTKFINRFDANCYIAITRKLDTHDLARDRVDDITEVLSTIQQP SLIIGIQSDGLFTYSEQEFLAEHIPKSQLEKIESPEGHDAFLLEFKLINKLIVQFLKT NCKAITDAAPRAWGGDVGNDETKTSVFGEAEEVTNW" gene 119268..120998 /gene="BOR1" /locus_tag="YNL275W" mRNA 119268..120998 /gene="BOR1" /locus_tag="YNL275W" /product="Bor1p" CDS 119268..120998 /gene="BOR1" /locus_tag="YNL275W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:16565073]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12447444|PMID:11401825]" /experiment="EXISTENCE:direct assay:GO:0046713 borate transport [PMID:17459946]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0080139 borate efflux transmembrane transporter activity [PMID:17459946]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:16565073]" /experiment="EXISTENCE:mutant phenotype:GO:0046713 borate transport [PMID:17459946|PMID:16923078|PMID:12447444]" /experiment="EXISTENCE:mutant phenotype:GO:0080139 borate efflux transmembrane transporter activity [PMID:12447444|PMID:17459946|PMID:16923078]" /note="Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1; human ortholog SLC4A5 is key biomarker and therapeutic target for Niemann-Pick type C (NPC) disease" /codon_start=1 /product="Bor1p" /protein_id="DAA10285.1" /db_xref="SGD:S000005219" /translation="MSNESTRVTVSRGCTASDECAQALERTNDELDRESSVSESRSDE ESHEKLSRRRFPTLGIGIWLDLKDRIPYYKSDWVDAFNYRVIPSIVDTYFNNLLPAIA FAQDMFDRTDNSYGVNEVLLSSAMAGIVFGVLGGQPLCIVGVTGPISIFNYTVYEIIK PLNTSYFGFMFWICMWSMIFHLVLAFTNAVCLLQYVTTFPCDIFGLFINVVYIQKGIQ ILTRQFSAKSGEKSVQDGFASVVVALVMTAFGLFFKLFHYYPLFSHRIRTFISDYSTA LSVLFWSSFTHFGGYLHDVKFKKLPITKAFFPTSKVNRPQNTWLAYEPIPVKDVFIAL PFGIFLTILFYFDHNVSSLMAQRHQYKLKKPSSFHYDFALLGLTTCISGVLGIPAPNG LIPQAPLHTETLLVRDSNQKVISCVEQRFTNTFQGLMILGTMTRPLLVCLGEIPQAVL SGLFFIMGINGLMTNSIIQRLVFLFSDPNRRDNTSPLMKVSKKSMLIFLSFSLTGFAG EFAITNTIAAIGFPLVLLLSVLVSFSFAYIFPTEELKILDTNVAQKFTIKNLLLENIR DAKFCDKHED" gene complement(121118..122170) /gene="GOR1" /locus_tag="YNL274C" mRNA complement(121118..122170) /gene="GOR1" /locus_tag="YNL274C" /product="glyoxylate reductase" CDS complement(121118..122170) /gene="GOR1" /locus_tag="YNL274C" /EC_number="1.1.1.26" /EC_number="1.1.1.79" /EC_number="1.1.1.81" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0009436 glyoxylate catabolic process [PMID:17173333]" /experiment="EXISTENCE:mutant phenotype:GO:0047964 glyoxylate reductase (NADH) activity [PMID:17173333]" /note="Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="glyoxylate reductase" /protein_id="DAA10286.1" /db_xref="SGD:S000005218" /translation="MSKKPIVLKLGKDAFGDQAWGELEKIADVITIPESTTREQFLRE VKDPQNKLSQVQVITRTARSVKNTGRFDEELALALPSSVVAVCHTGAGYDQIDVEPFK KRHIQVANVPDLVSNATADTHVFLLLGALRNFGIGNRRLIEGNWPEAGPACGSPFGYD PEGKTVGILGLGRIGRCILERLKPFGFENFIYHNRHQLPSEEEHGCEYVGFEEFLKRS DIVSVNVPLNHNTHHLINAETIEKMKDGVVIVNTARGAVIDEQAMTDALRSGKIRSAG LDVFEYEPKISKELLSMSQVLGLPHMGTHSVETRKKMEELVVENAKNVILTGKVLTIV PELQNEDWPNESKPLV" gene 122883..126599 /gene="TOF1" /locus_tag="YNL273W" mRNA 122883..126599 /gene="TOF1" /locus_tag="YNL273W" /product="Tof1p" CDS 122883..126599 /gene="TOF1" /locus_tag="YNL273W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:19819872]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:16103218]" /experiment="EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:16219777]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:17483413|PMID:14742714]" /experiment="EXISTENCE:mutant phenotype:GO:0000076 DNA replication checkpoint signaling [PMID:12944972]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:16137625]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:16219777]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:17483413|PMID:14742714]" /experiment="EXISTENCE:mutant phenotype:GO:0031297 replication fork processing [PMID:18632578]" /experiment="EXISTENCE:mutant phenotype:GO:0043111 replication fork arrest [PMID:16418273|PMID:17652453|PMID:16103218]" /experiment="EXISTENCE:mutant phenotype:GO:0043570 maintenance of DNA repeat elements [PMID:18321795]" /note="Subunit of a replication-pausing checkpoint complex; the replication fork protection complex (Tof1p-Mrc1p-Csm3p) acts at stalled forks and is required for rapid replication fork progression, replisome stabilization under stress, mediating checkpoint signaling and promoting sister chromatid cohesion after damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; recruits Top1p to the fork to suppress DNA damage; relocalizes to the cytosol in response to hypoxia to hypoxia" /codon_start=1 /product="Tof1p" /protein_id="DAA10287.1" /db_xref="SGD:S000005217" /translation="MSADLQQGTTNAADFSLTVLRARIALLATAIGGPDYTSQIDPPP YKLGDDCLACLKDLKRWFKLVDDQQKRWDVAMAVAEYRILTDDLLPILIDWENKCSLA AKLAKNNPDHEEFRNKAYYDKIALNCLQLLVLMTWPLIVTEQSSSNQITLYGELKKHQ LVYKKTILSMESGKVLRAAIRLALDVIKIDRLSRTPRDNMVLKLVLNFFRNVIAIEPG EFTINTKKSMPKKGITSIDTLPPNVSMDDISLNTVISSFHKNKVFGFLLTLTSSLSKE FDQDFINIPLLEIMFYFTKDVNQELLFPRQFETGTHSKVVNKNESSSANNIVTSAGFE LSKLLQKEHQMRKNVIKHTSARHSRFGGLLSIQTPDKTRLTVSGSQALVDEKIALQKL DDSKKWNKRIIKKHQSVAAEGLPNSLLNSQTGKAIFFTESNGKHFKEFINNFIDSGFN ILLHSVTNYFTTEQDRMVTLEQVEYLLFFAWFVKYQLLRSKIDNSADIKQVSEALKEV TFILVSSLLRSAYDLKNWTVTHAGMIAFNELLNLVSRTKAAQEEDSTDIEFIVSRLFS DERIQLLSNLPKIGSKYSLQFMKSCIELTHSVLKVLEQYSDDKTLVIEGKSRRQKKFN ISEGDITKLIEEENVDRDEALDILTSSLRSIEVNFQKVQANYMTEPVIETYINFLERF RELEDDSIKKVFSFFHRVFVQAKEQALLFRFDLIILLREMLSPDGLDRMSRSRKYVSQ FSDYFLARLKKRLKKSPAWFVGLLFPPLHNSEVGFYQRYGEYNVLNNESMYAAPASQF KPIPDEEALPPSILLDMKYGVLVSTLLDDGKTELLDQLLKHITHTLDIFKSWLTVNVN AGKETVNPPNEYFTLTGVLNNDPIFKDKDYRALLLLIGYSIPRKINEPCFLPGTVEVS DLTVSCELVKKYLSTPFETPNGLPSSSYLLRVRSEKDSFSHNEQDGWEGDDDYDYNDP YIVPDDQILSKSDAAYFKDLDNNASDKLKGTKFSKGIARSKKKDKRKRRKGEAKTNLP MFGDQDDERPQTVRERHGVFSKEFISDSEDDEDLMNPIFFENETYMRWLLDKNNGQLT EDRYIQFAKFAAERMNNGGVVTGDYTSLFGGSIPSIESIRATESSSFAPDKSLISLAS HVASEMSIFDVNNNNNNQLSDDDVNSESRNSLGSSQPSNSQNMFQSEVYSRKESTKRS LEASAADESDEDEEAIRLFGKKSRVVLSQGDSDD" rep_origin 126599..126805 /note="ARS1410; Replication origin; identified in multiple array studies, confirmed by plasmid-based recombinational ARS assay" /db_xref="SGD:S000130141" gene complement(126805..129084) /gene="SEC2" /locus_tag="YNL272C" mRNA complement(126805..129084) /gene="SEC2" /locus_tag="YNL272C" /product="guanine nucleotide exchange factor SEC2" CDS complement(126805..129084) /gene="SEC2" /locus_tag="YNL272C" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:9199166]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12045183]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:20493815]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:20493815]" /experiment="EXISTENCE:direct assay:GO:0030133 transport vesicle [PMID:12045183]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:20493815]" /experiment="EXISTENCE:genetic interaction:GO:0006914 autophagy [PMID:20444978]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:12045183]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:20444978]" /experiment="EXISTENCE:mutant phenotype:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:29293994]" /experiment="EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:29293994]" /experiment="EXISTENCE:mutant phenotype:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:20493815]" /note="Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles" /codon_start=1 /product="guanine nucleotide exchange factor SEC2" /protein_id="DAA10288.1" /db_xref="SGD:S000005216" /translation="MDASEEAKRVSIQVTSLSTQLIESVDKQSHLEEQLNKSLKTIAS QKAAIENYNQLKEDYNTLKRELSDRDDEVKRLREDIAKENELRTKAEEEADKLNKEVE DLTASLFDEANNMVADARKEKYAIEILNKRLTEQLREKDTLLDTLTLQLKNLKKVMHS LDNESTVTNNSNRYSTILSDSATSSSTSLNKVPTSYSLASQDIYSGIVYSPSISSIRY DISLYNEFLKFVAALPRCENIKATSTESKLIRRLVNDEIQPILKIDNASGIGWLVKKT LLSLIIDGLVVVEPLSGVNATYQIGYNSSSPAKQATSNMPKMFKFPLDSPPVAVHAAC SFCGESRDDIIEHARMYILKTLHKTDDGKEQVTNTYPLCHWCLLKLRQTCEIFAFLRS LKVGAWHLEKLTTQNITKEDLEKFSEVTKHTKRDGRVSSQDKKTKRLSFMAGLGINSS TKNKPKMEIFSSETNAKPGQPTTNIQRAWLQLCKLRCILHWTHIGIWAVDDSISSKIG PLVEDDSDEDQNDAISVRLQDKALWKQDAKRPFSSSSAEESQKSDAFDFESGDMENEI TGESSSDESSSDGSSTDNSTADSSSEDESSLADSTTSSADSSSPESIDNGEGDDTVTK DDKSSIKSANNNEENSDCGDKKGRSIIKKKAPQRKIQKKKLLQDLDDLEEQFREESAI DQTEFENAESNVKQNISSKRASSGDENSKKDNNEKTLKTNLTIGDKTQEQIGENSPSS GLHASSSNDDNFDDAQEQQ" gene complement(129522..135383) /gene="BNI1" /locus_tag="YNL271C" /gene_synonym="PPF3" /gene_synonym="SHE5" mRNA complement(129522..135383) /gene="BNI1" /locus_tag="YNL271C" /gene_synonym="PPF3" /gene_synonym="SHE5" /product="formin BNI1" CDS complement(129522..135383) /gene="BNI1" /locus_tag="YNL271C" /gene_synonym="PPF3" /gene_synonym="SHE5" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11154270]" /experiment="EXISTENCE:direct assay:GO:0000133 polarisome [PMID:9571251|PMID:16166638]" /experiment="EXISTENCE:direct assay:GO:0005522 profilin binding [PMID:12134165|PMID:15923184]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:38656798]" /experiment="EXISTENCE:direct assay:GO:0005884 actin filament [PMID:12052901]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11154270]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11154270]" /experiment="EXISTENCE:direct assay:GO:0032153 cell division site [PMID:26771880]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807|PMID:38656798|PMID:9082982]" /experiment="EXISTENCE:direct assay:GO:0045010 actin nucleation [PMID:12052901]" /experiment="EXISTENCE:direct assay:GO:0051016 barbed-end actin filament capping [PMID:14561409]" /experiment="EXISTENCE:direct assay:GO:0070649 formin-nucleated actin cable assembly [PMID:12134165]" /experiment="EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:10866679]" /experiment="EXISTENCE:genetic interaction:GO:0032956 regulation of actin cytoskeleton organization [PMID:17237521]" /experiment="EXISTENCE:genetic interaction:GO:0051017 actin filament bundle assembly [PMID:23671312]" /experiment="EXISTENCE:genetic interaction:GO:0070649 formin-nucleated actin cable assembly [PMID:11740491]" /experiment="EXISTENCE:genetic interaction:GO:0071474 cellular hyperosmotic response [PMID:17237521]" /experiment="EXISTENCE:genetic interaction:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:12419188]" /experiment="EXISTENCE:mutant phenotype:GO:0000132 establishment of mitotic spindle orientation [PMID:10085293]" /experiment="EXISTENCE:mutant phenotype:GO:0005522 profilin binding [PMID:15923184]" /experiment="EXISTENCE:mutant phenotype:GO:0005934 cellular bud tip [PMID:16166638]" /experiment="EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:10866679]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:16166638|PMID:10085294]" /experiment="EXISTENCE:mutant phenotype:GO:0032956 regulation of actin cytoskeleton organization [PMID:17237521]" /experiment="EXISTENCE:mutant phenotype:GO:0051017 actin filament bundle assembly [PMID:23671312]" /experiment="EXISTENCE:mutant phenotype:GO:0070649 formin-nucleated actin cable assembly [PMID:11740491]" /experiment="EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:17237521]" /experiment="EXISTENCE:physical interaction:GO:0000133 polarisome [PMID:9571251]" /note="Formin; polarisome component; nucleates the formation of linear actin filaments, involved in budding and mitotic spindle orientation which require the formation of polarized actin cables; recruited to the division site in a Glc7p/Ref2p dependent manner following release of Bnr1p; spatially focuses Bni1p at mating projection tips, and with Bud6p organizes Bni1p into clusters that nucleate actin assembly during mating projection formation; some functional redundancy with BNR1" /codon_start=1 /product="formin BNI1" /protein_id="DAA10289.2" /db_xref="SGD:S000005215" /translation="MLKNSGSKHSNSKESHSNSSSGIFQNLKRLANSNATNSNTGSPT YASQQQHSPVGNEVSTSPASSSSFRKLNAPSRSTSTEARPLNKKSTLNTQNLSQYMNG KLSGDVPVSSQHARSHSMQSKYSYSKRNSSQASNKLTRQHTGQSHSASSLLSQGSLTN LSKFTTPDGKIYLEMPSDPYEVEVLFEDIMYKRNIFQSLSEDKQEALMGYSIEKKWLI VKQDLQNELKKMRANTTSSSTASRTSMASDHHPILTANSSLSSPKSVLMTSASSPTST VYSNSLNHSTTLSSVGTSTSKGKKLVSGSLKKQPSLNNIYRGGAENNTSASTLPGDRT NRPPIHYVQRILADKLTSDEMKDLWVTLRTEQLDWVDAFIDHQGHIAMANVLMNSIYK TAPRENLTKELLEKENSFFKCFRVLSMLSQGLYEFSTHRLMTDTVAEGLFSTKLATRK MATEIFVCMLEKKNKSRFEAVLTSLDKKFRIGQNLHMIQNFKKMPQYFSHLTLESHLK IIQAWLFAVEQTLDGRGKMGSLVGASDEFKNGGGENAILEYCQWTMVFINHLCSCSDN INQRMLLRTKLENCGILRIMNKIKLLDYDKVIDQIELYDNNKLDDFNVKLEANNKAFN VDLHDPLSLLKNLWDICKGTENEKLLVSLVQHLFLSSSKLIEENQNSSKLTKQLKLMD SLVTNVSVASTSDEETNMNMAIQRLYDAMQTDEVARRAILESRALTKKLEEIQAERDS LSEKLSKAEHGLVGQLEDELHERDRILAKNQRVMQQLEAELEELKKKHLLEKHQQEVE LRKMLTILNSRPEESFNKNEGTRGMNSSLNSSEKANIQKVLQDGLSRAKKDYKDDSKK FGMTLQPNKRLKMLRMQMENIENEARQLEMTNFAEFEKDRLEPPIHIKKPKVKKMKNK DRKPLVKPQEADVNKLNDLRRALAEIQMESNDISKFNVEERVNELFNEKKSLALKRLK ELETKYKGFGIDFNVDEIMDSPKKNTGDVETEEDANYASLDPKTYQKKLDEINRITDQ LLDIQTQTEHEIQVEEDGESDLSSSSSDDESEEIYQDASPTQELRSEHSELSSGSGPG SFLDALSQKYGTGQNVTASAAFGENNNGSGIGPLHSKVEKTFMNRLRKSTVSSAPYLE ELTQKVNKVEPYEQNEDEGLDKKSLPENSTASAASAFDKAEKDMRQHVENGKQGRVVN HEEDKTADFSAVSKLNNTDGAEDLSTQSSVLSSQPPPPPPPPPPVPAKLFGESLEKEK KSEDDTVKQETTGDSPAPPPPPPPPPPPPMALFGKPKGETPPPPPLPSVLSSSTDGVI PPAPPMMPASQIKSAVTSPLLPQSPSLFEKYPRPHKKLKQLHWEKLDCTDNSIWGTGK AEKFADDLYEKGVLADLEKAFAAREIKSLASKRKEDLQKITFLSRDISQQFGINLHMY SSLSVADLVKKILNCDRDFLQTPSVVEFLSKSEIIEVSVNLARNYAPYSTDWEGVRNL EDAKPPEKDPNDLQRADQIYLQLMVNLESYWGSRMRALTVVTSYEREYNELLAKLRKV DKAVSALQESDNLRNVFNVILAVGNFMNDTSKQAQGFKLSTLQRLTFIKDTTNSMTFL NYVEKIVRLNYPSFNDFLSELEPVLDVVKVSIEQLVNDCKDFSQSIVNVERSVEIGNL SDSSKFHPLDKVLIKTLPVLPEARKKGDLLEDEVKLTIMEFESLMHTYGEDSGDKFAK ISFFKKFADFINEYKKAQAQNLAAEEEERLYIKHKKIVEEQQKRAQEKEKQKENSNSP SSEGNEEDEAEDRRAVMDKLLEQLKNAGPAKSDPSSARKRALVRKKYLSEKDNAPQLL NDLDTEEGSILYSPEAMDPTADTVIHAESPTPLATRGVMNTSEDLPSPSKTSALEDQE EISDRARMLLKELRGSDTPVKQNSILDEHLEKLRARKERSIGEASTGNRLSFK" gene complement(135940..137661) /gene="ALP1" /locus_tag="YNL270C" /gene_synonym="APL1" mRNA complement(135940..137661) /gene="ALP1" /locus_tag="YNL270C" /gene_synonym="APL1" /product="arginine permease ALP1" CDS complement(135940..137661) /gene="ALP1" /locus_tag="YNL270C" /gene_synonym="APL1" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0015174 basic amino acid transmembrane transporter activity [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0015802 basic amino acid transport [PMID:10654085]" /note="Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication" /codon_start=1 /product="arginine permease ALP1" /protein_id="DAA10290.1" /db_xref="SGD:S000005214" /translation="MDETVNIQMSKEGQYEINSSSIIKEEEFVDEQYSGENVTKAITT ERKVEDDAAKETESSPQERREVKRKLKQRHIGMIALGGTIGTGLIIGIGPPLAHAGPV GALISYLFMGTVIYSVTQSLGEMVTFIPVTSSFSVFAQRFLSPALGATNGYMYWLSWC FTFALELSVLGKVIQYWTEAVPLAAWIVIFWCLLTSMNMFPVKYYGEFEFCIASIKVI ALLGFIIFSFCVVCGAGQSDGPIGFRYWRNPGAWGPGIISSDKNEGRFLGWVSSLINA AFTYQGTELVGITAGEAANPRKALPRAIKKVVVRILVFYILSLFFIGLLVPYNDPKLD SDGIFVSSSPFMISIENSGTKVLPDIFNAVVLITILSAGNSNVYIGSRVLYSLSKNSL APRFLSNVTRGGVPYFSVLSTSVFGFLAFLEVSAGSGKAFNWLLNITGVAGFFAWLLI SFSHIRFMQAIRKRGISRDDLPYKAQMMPFLAYYASFFIALIVLIQGFTAFAPTFQPI DFVAAYISIFLFLAIWLSFQVWFKCRLLWKLQDIDIDSDRRQIEELVWIEPECKTRWQ RVWDVLS" gene 137699..138094 /gene="BSC4" /locus_tag="YNL269W" mRNA 137699..138094 /gene="BSC4" /locus_tag="YNL269W" /product="Bsc4p" CDS 137699..138094 /gene="BSC4" /locus_tag="YNL269W" /note="hypothetical protein; protein-coding gene that evolved de novo via a series of point mutations in noncoding sequence; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p; may be involved in DNA repair pathway during stationary phase and contribute to robustness of cells when shifted to a nutrient-poor environment" /codon_start=1 /product="Bsc4p" /protein_id="DAA10291.1" /db_xref="SGD:S000005213" /translation="MSIVLRKSNKKNKNCITSKFYTIHIIKISTPVFRAPIAIGESPY VEWSCLQVVFRKDMVTKKTTFAQLITRLNHFLCQALKRRDSKTYILCRTAVFGAMTPF SPRKSHINNKLPMQPRKKKIVIIYVVRFH" gene 138550..140385 /gene="LYP1" /locus_tag="YNL268W" mRNA 138550..140385 /gene="LYP1" /locus_tag="YNL268W" /product="lysine permease" CDS 138550..140385 /gene="LYP1" /locus_tag="YNL268W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0015174 basic amino acid transmembrane transporter activity [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0015802 basic amino acid transport [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:29402931]" /experiment="EXISTENCE:genetic interaction:GO:0089718 amino acid import across plasma membrane [PMID:40247776]" /note="Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids; broad substrate specificity when overexpressed in a strain severely deficient for the uptake of amino acids; predominantly located in the plasma membrane during exponential growth" /codon_start=1 /product="lysine permease" /protein_id="DAA10292.1" /db_xref="SGD:S000005212" /translation="MGRFSNIITSNKWDEKQNNIGEQSMQELPEDQIEHEMEAIDPSN KTTPYSIDEKQYNTKKKHGSLQGGAIADVNSITNSLTRLQVVSHETDINEDEEEAHYE DKHVKRALKQRHIGMIALGGTIGTGLFVGISTPLSNAGPVGSLIAYIFMGTIVYFVTQ SLGEMATFIPVTSSITVFSKRFLSPAFGVSNGYMYWFNWAITYAVEVSVIGQVIEYWT DKVPLAAWIAIFWVIITLMNFFPVKVYGEFEFWVASVKVLAIMGYLIYALIIVCGGSH QGPIGFRYWRNPGAWGPGIISSDKSEGRFLGWVSSLINAAFTYQGTELVGITAGEAAN PRKTVPRAINKVVFRIVLFYIMSLFFIGLLVPYNDSRLSASSAVIASSPFVISIQNAG TYALPDIFNAVVLITVVSAANSNVYVGSRVLYSLARTGNAPKQFGYVTRQGVPYLGVV CTAALGLLAFLVVNNNANTAFNWLINISTLAGLCAWLFISLAHIRFMQALKHRGISRD DLPFKAKLMPYGAYYAAFFVTVIIFIQGFQAFCPFKVSEFFTSYISLILLAVVFIGCQ IYYKCRFIWKLEDIDIDSDRREIEAIIWEDDEPKNLWEKFWAAVA" gene 140878..144078 /gene="PIK1" /locus_tag="YNL267W" /gene_synonym="PIK120" /gene_synonym="PIK41" mRNA 140878..144078 /gene="PIK1" /locus_tag="YNL267W" /gene_synonym="PIK120" /gene_synonym="PIK41" /product="1-phosphatidylinositol 4-kinase" CDS 140878..144078 /gene="PIK1" /locus_tag="YNL267W" /gene_synonym="PIK120" /gene_synonym="PIK41" /EC_number="2.7.1.67" /experiment="EXISTENCE:direct assay:GO:0004430 1-phosphatidylinositol 4-kinase activity [PMID:8248783|PMID:8194527]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10587649|PMID:16365163|PMID:8194527]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:16365163|PMID:10587649]" /experiment="EXISTENCE:direct assay:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:8194527|PMID:8248783]" /experiment="EXISTENCE:mutant phenotype:GO:0004430 1-phosphatidylinositol 4-kinase activity [PMID:10587649]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:32726584]" /experiment="EXISTENCE:mutant phenotype:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:10587649]" /experiment="EXISTENCE:mutant phenotype:GO:0140504 microlipophagy [PMID:32726584]" /experiment="EXISTENCE:mutant phenotype:GO:2000786 positive regulation of autophagosome assembly [PMID:31125705]" /note="Phosphatidylinositol 4-kinase; catalyzes the first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton; required for autophagosome formation during autophagy and for lipophagy in both stationary phase cells and during nitrogen starvation; may control nonselective autophagy and mitophagy through trafficking of Atg9p; localizes to the nucleus and to the trans-Golgi network" /codon_start=1 /product="1-phosphatidylinositol 4-kinase" /protein_id="DAA10293.1" /db_xref="SGD:S000005211" /translation="MHKASSSKKSFDDTIELKKNEQLLKLINSSEFTLHNCVELLCKH SENIGIHYYLCQKLATFPHSELQFYIPQLVQVLVTMETESMALEDLLLRLRAENPHFA LLTFWQLQALLTDLSTDPASYGFQVARRVLNNLQTNLFNTSSGSDKNVKIHENVAPAL VLSSMIMSAIAFPQLSEVTKPLVESQGRRQKAFVFKLARSAMKDFTKNMTLKNTLLNK KTSRSKRVSSNRSSTPTSPIDLIDPIKTKEDASFRKSRHSEVKLDFDIVDDIGNQVFE ERISSSIKLPKRKPKYLDNSYVHRTYDGKNINRDGSISNTAKALDGNKGDYISPKGRN DENNEIGNNEDETGGETEEDADALNSDHFTSSMPDLHNIQPRTSSASSASLEGTPKLN RTNSQPLSRQAFKNSKKANSSLSQEIDLSQLSTTSKIKMLKANYFRCETQFAIALETI SQRLARVPTEARLSALRAELFLLNRDLPAEVDIPTLLPPNKKGKLHKLVTITANEAQV LNSAEKVPYLLLIEYLRDEFDFDPTSETNERLLKKISGNQGGLIFDLNYMNRKENNEN RNESTLTSNNTRSSVYDSNSFNNGASRNEGLSSTSRSDSASTAHVRTEVNKEEDLGDM SMVKVRNRTDDEAYRNALVIQSAANVPILPDDSQDRSPELNFGSNLDEVLIENGINSK NIHSQTDALADQMRVSAVMLAQLDKSPQQLSESTKQIRAQIISSMKEVQDKFGYHDLE ALHGMAGERKLENDLMTGGIDTSYLGEDWATKKERIRKTSEYGHFENWDLCSVIAKTG DDLRQEAFAYQMIQAMANIWVKEKVDVWVKRMKILITSANTGLVETITNAMSVHSIKK ALTKKMIEDAELDDKGGIASLNDHFLRAFGNPNGFKYRRAQDNFASSLAAYSVICYLL QVKDRHNGNIMIDNEGHVSHIDFGFMLSNSPGSVGFEAAPFKLTYEYIELLGGVEGEA FKKFVELTKSSFKALRKYADQIVSMCEIMQKDNMQPCFDAGEQTSVQLRQRFQLDLSE KEVDDFVENFLIGKSLGSIYTRIYDQFQLITQGIYS" gene complement(144280..145281) /gene="IST1" /locus_tag="YNL265C" mRNA complement(join(144280..145149,145255..145281)) /gene="IST1" /locus_tag="YNL265C" /product="Ist1p" CDS complement(join(144280..145149,145255..145281)) /gene="IST1" /locus_tag="YNL265C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18032584]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:36125415|PMID:14562095|PMID:18032584]" /experiment="EXISTENCE:direct assay:GO:0042030 ATPase inhibitor activity [PMID:18032582]" /experiment="EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:18032584]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:18032582]" /experiment="EXISTENCE:mutant phenotype:GO:0042030 ATPase inhibitor activity [PMID:36125415]" /experiment="EXISTENCE:mutant phenotype:GO:0099638 endosome to plasma membrane protein transport [PMID:36125415]" /note="Protein involved in recycling of membrane transporters from endosome to plasma membrane; plays a role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p" /codon_start=1 /product="Ist1p" /protein_id="DAA10294.1" /db_xref="SGD:S000005209" /translation="MAPSMIPFTIKLKTCLKMCIQRLRYAQEKQQAIAKQSRRQVAQL LLTNKEQKAHYRVETLIHDDIHIELLEILELYCELLLARVQVINDISTEEQLVKEHMD DGINEAIRSLIYAILFVDEVKELSQLKDLMAWKINVEFVNGVIADHIDVPEKIIKKCS PSVPKEELVDLYLKEIAKTYDVPYSKLENSLSSSSSNISSDFSDPSGDIEDNDEEKPI LALDNDDNDNADAKHPITVKKPRQNSENIKNELKIPKDIKKEVIEKKQSEKKTTKRKT KKEQENDELDELKKRFDALRRK" gene complement(145563..146615) /gene="PDR17" /locus_tag="YNL264C" /gene_synonym="ISS1" /gene_synonym="SFH4" mRNA complement(145563..146615) /gene="PDR17" /locus_tag="YNL264C" /gene_synonym="ISS1" /gene_synonym="SFH4" /product="phosphatidylinositol transporter" CDS complement(145563..146615) /gene="PDR17" /locus_tag="YNL264C" /gene_synonym="ISS1" /gene_synonym="SFH4" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:20016005]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:12869188]" /experiment="EXISTENCE:direct assay:GO:0008526 phosphatidylinositol transfer activity [PMID:10799527|PMID:10848624]" /experiment="EXISTENCE:direct assay:GO:0015914 phospholipid transport [PMID:10848624|PMID:10799527]" /experiment="EXISTENCE:direct assay:GO:0016126 sterol biosynthetic process [PMID:36482167]" /experiment="EXISTENCE:direct assay:GO:0032934 sterol binding [PMID:36482167]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:12869188]" /experiment="EXISTENCE:genetic interaction:GO:0008526 phosphatidylinositol transfer activity [PMID:9890948]" /experiment="EXISTENCE:genetic interaction:GO:0008654 phospholipid biosynthetic process [PMID:9890948]" /experiment="EXISTENCE:genetic interaction:GO:0009410 response to xenobiotic stimulus [PMID:9890948]" /experiment="EXISTENCE:genetic interaction:GO:0015914 phospholipid transport [PMID:9890948]" /experiment="EXISTENCE:genetic interaction:GO:0043001 Golgi to plasma membrane protein transport [PMID:10848624]" /experiment="EXISTENCE:genetic interaction:GO:1901352 negative regulation of phosphatidylglycerol biosynthetic process [PMID:12869188]" /experiment="EXISTENCE:genetic interaction:GO:2001247 positive regulation of phosphatidylcholine biosynthetic process [PMID:12869188]" /experiment="EXISTENCE:mutant phenotype:GO:0006658 phosphatidylserine metabolic process [PMID:10799527]" /experiment="EXISTENCE:mutant phenotype:GO:0008526 phosphatidylinositol transfer activity [PMID:9890948]" /experiment="EXISTENCE:mutant phenotype:GO:0015914 phospholipid transport [PMID:9890948]" /note="Phosphatidylinositol transfer protein (PITP); downregulates Plb1p-mediated turnover of phosphatidylcholine; forms a complex with Psd2p which appears essential for maintenance of vacuolar PE levels; found in the cytosol and microsomes; homologous to Pdr16p; deletion affects phospholipid composition" /codon_start=1 /product="phosphatidylinositol transporter" /protein_id="DAA10295.1" /db_xref="SGD:S000005208" /translation="MGLFSRKRDHTPAVPKEKLIPCDKIFLDPPAKYGNAPLLEPISE DQNEKYRAVLRHFQDDDLKLPENLNDLDNGTHANDRPLSDWEKFWLSRECFLRYLRAN KWNTANAIKGLTKTLVWRREIGLTHGKEDKDPLTADKVAVENETGKQVILGFDNAKRP LYYMKNGRQNTESSFRQVQELVYMMETATTVAPQGVEKITVLVDFKSYKEPGIITDKA PPISIARMCLNVMQDHYPERLAKCVLINIPWFAWAFLKMMYPFLDPATKAKAIFDEPF ENHIEPSQLDALYNGLLDFKYKHEVYWPDMVKKVDDLRLKRFDRFLKFGGIVGLSEYD TKGQHDELKYPVDMVI" gene complement(146896..147840) /gene="YIF1" /locus_tag="YNL263C" mRNA complement(146896..147840) /gene="YIF1" /locus_tag="YNL263C" /product="protein transporter YIF1" CDS complement(146896..147840) /gene="YIF1" /locus_tag="YNL263C" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:10970842]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10970842]" /experiment="EXISTENCE:physical interaction:GO:0005789 endoplasmic reticulum membrane [PMID:15659647]" /note="Integral membrane protein; required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3" /codon_start=1 /product="protein transporter YIF1" /protein_id="DAA10296.1" /db_xref="SGD:S000005207" /translation="MSYNPYAYATSEQNGVNDRFSHTPQQQRPMQIPRNTPVNGQGNA NMNANVNGSGGGFPFQDPRGSMAFQLGQSAFSNFIGQDNFNQFQETVNKATANAAGSQ QISTYFQVSTRYVINKLKLILVPFLNGTKNWQRIMDSGNFLPPRDDVNSPDMYMPIMG LVTYILIWNTQQGLKGSFNPEDLYYKLSSTLAFVCLDLLILKLGLYLLIDSKIPSFSL VELLCYVGYKFVPLILAQLLTNVTMPFNLNILIKFYLFIAFGVFLLRSVKFNLLSRSG AEDDDIHVSISKSTVKKCNYFLFVYGFIWQNVLMWLMG" gene 148212..154880 /gene="POL2" /locus_tag="YNL262W" /gene_synonym="DUN2" mRNA 148212..154880 /gene="POL2" /locus_tag="YNL262W" /gene_synonym="DUN2" /product="DNA polymerase epsilon catalytic subunit" CDS 148212..154880 /gene="POL2" /locus_tag="YNL262W" /gene_synonym="DUN2" /EC_number="2.7.7.7" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:16916794|PMID:14622139]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:14622139]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:16369485]" /experiment="EXISTENCE:direct assay:GO:0005657 replication fork [PMID:15773893|PMID:18851837]" /experiment="EXISTENCE:direct assay:GO:0006261 DNA-templated DNA replication [PMID:14622139|PMID:16369485]" /experiment="EXISTENCE:direct assay:GO:0008622 epsilon DNA polymerase complex [PMID:12571237|PMID:2406268]" /experiment="EXISTENCE:direct assay:GO:0032183 SUMO binding [PMID:31765407]" /experiment="EXISTENCE:direct assay:GO:0042276 error-prone translesion synthesis [PMID:19776424]" /experiment="EXISTENCE:genetic interaction:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:18437220]" /experiment="EXISTENCE:genetic interaction:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:18851837|PMID:8895664]" /experiment="EXISTENCE:mutant phenotype:GO:0003887 DNA-directed DNA polymerase activity [PMID:1537345]" /experiment="EXISTENCE:mutant phenotype:GO:0006272 leading strand elongation [PMID:17615360]" /experiment="EXISTENCE:mutant phenotype:GO:0006284 base-excision repair [PMID:8423775]" /experiment="EXISTENCE:mutant phenotype:GO:0006297 nucleotide-excision repair, DNA gap filling [PMID:11452038]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:10025407]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:18437220]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:12665575]" /experiment="EXISTENCE:mutant phenotype:GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity [PMID:1658784]" /experiment="EXISTENCE:mutant phenotype:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:8895664]" /experiment="EXISTENCE:mutant phenotype:GO:0033314 mitotic DNA replication checkpoint signaling [PMID:9792727]" /experiment="EXISTENCE:mutant phenotype:GO:0035822 gene conversion [PMID:20595613]" /experiment="EXISTENCE:mutant phenotype:GO:0045004 DNA replication proofreading [PMID:21124948|PMID:1658784]" /experiment="EXISTENCE:physical interaction:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:18851837]" /note="Catalytic subunit of DNA polymerase (II) epsilon; a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; participates in leading-strand synthesis during DNA replication; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p" /codon_start=1 /product="DNA polymerase epsilon catalytic subunit" /protein_id="DAA10297.1" /db_xref="SGD:S000005206" /translation="MMFGKKKNNGGSSTARYSAGNKYNTLSNNYALSAQQLLNASKID DIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLTNMHATLVSQETLSSGSNGGGNS NDGERVTTNQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVNDVEELVKKYL ESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLFEARKLLRPILQDNANNNV QRNIYNVAANGSEKVDAKHLIEDIREYDVPYHVRVSIDKDIRVGKWYKVTQQGFIEDT RKIAFADPVVMAFDIETTKPPLKFPDSAVDQIMMISYMIDGEGFLITNREIISEDIED FEYTPKPEYPGFFTIFNENDEVALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSK IHGLDMFDEIGFAPDAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYN PIELDPELMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETL RKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHVESLEAGVF RSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTNFEEIKNQITQKLLEL KENNIRNELPLIYHVDVASMYPNIMTTNRLQPDSIKAERDCASCDFNRPGKTCARKLK WAWRGEFFPSKMDEYNMIKRALQNETFPNKNKFSKKKVLTFDELSYADQVIHIKKRLT EYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKI DPSDKHARDEAKKMIVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGITCLTGAT IIQMARALVERVGRPLELDTDGIWCILPKSFPETYFFTLENGKKLYLSYPCSMLNYRV HQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVF NEDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRWLDVL DSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRLGDFLGEDMVKDKGLQ CKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRWTLDPSLEDLDIRTIIDWGYY RERLGSAIQKIITIPAALQGVSNPVPRVEHPDWLKRKIATKEDKFKQTSLTKFFSKTK NVPTMGKIKDIEDLFEPTVEEDNAKIKIARTTKKKAVSKRKRNQLTNEEDPLVLPSEI PSMDEDYVGWLNYQKIKWKIQARDRKRRDQLFGNTNSSRERSALGSMIRKQAESYANS TWEVLQYKDSGEPGVLEVFVTINGKVQNITFHIPKTIYMKFKSQTMPLQKIKNCLIEK SSASLPNNPKTSNPAGGQLFKITLPESVFLEEKENCTSIFNDENVLGVFEGTITPHQR AIMDLGASVTFRSKAMGALGKGIQQGFEMKDLSMAENERYLSGFSMDIGYLLHFPTSI GYEFFSLFKSWGDTITILVLKPSNQAQEINASSLGQIYKQMFEKKKGKIETYSYLVDI KEDINFEFVYFTDISKLYRRLSQETTKLKEERGLQFLLLLQSPFITKLLGTIRLLNQM PIVKLSLNEVLLPQLNWQPTLLKKLVNHVLSSGSWISHLIKLSQYSNIPICNLRLDSM DYIIDVLYARKLKKENIVLWWNEKAPLPDHGGIQNDFDLNTSWIMNDSEFPKINNSGV YDNVVLDVGVDNLTVNTILTSALINDAEGSDLVNNNMGIDDKDAVINSPSEFVHDAFS NDALNVLRGMLKEWWDEALKENSTADLLVNSLASWVQNPNAKLFDGLLRYHVHNLTKK ALLQLVNEFSALGSTIVYADRNQILIKTNKYSPENCYAYSQYMMKAVRTNPMFSYLDL NIKRYWDLLIWMDKFNFSGLACIEIEEKENQDYTAVSQWQLKKFLSPIYQPEFEDWMM IILDSMLKTKQSYLKLNSGTQRPTQIVNVKKQDKEDSVENSLNGFSHLFSKPLMKRVK KLFKNQQEFILDPQYEADYVIPVLPGSHLNVKNPLLELVKSLCHVMLLSKSTILEIRT LRKELLKIFELREFAKVAEFKDPSLSLVVPDFLCEYCFFISDIDFCKAAPESIFSCVR CHKAFNQVLLQEHLIQKLRSDIESYLIQDLRCSRCHKVKRDYMSAHCPCAGAWEGTLP RESIVQKLNVFKQVAKYYGFDILLSCIADLTI" gene 155100..156539 /gene="ORC5" /locus_tag="YNL261W" mRNA 155100..156539 /gene="ORC5" /locus_tag="YNL261W" /product="origin recognition complex subunit 5" CDS 155100..156539 /gene="ORC5" /locus_tag="YNL261W" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194|PMID:9335335]" /experiment="EXISTENCE:direct assay:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:12897051]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]" /experiment="EXISTENCE:genetic interaction:GO:0006270 DNA replication initiation [PMID:7579692]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:9038340]" /experiment="EXISTENCE:mutant phenotype:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:16716188|PMID:7579692]" /note="Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing" /codon_start=1 /product="origin recognition complex subunit 5" /protein_id="DAA10298.1" /db_xref="SGD:S000005205" /translation="MNVTTPEVAFREYQTNCLASYISADPDITPSNLILQGYSGTGKT YTLKKYFNANPNLHAVWLEPVELVSWKPLLQAIARTVQYKLKTLYPNIPTTDYDPLQV EEPFLLVKTLHNIFVQYESLQEKTCLFLILDGFDSLQDLDAALFNKYIKLNELLPKDS KINIKFIYTMLETSFLQRYSTHCIPTVMFPRYNVDEVSTILVMSRCGELMEDSCLRKR IIEEQITDCTDDQFQNVAANFIHLIVQAFHSYTGNDIFALNDLIDFKWPKYVSRITKE NIFEPLALYKSAIKLFLSTDDNLSENGQGESAITTNRDDLENSQTYDLSIISKYLLIA SYICSYLEPRYDASIFSRKTRIIQGRAAYGRRKKKEVNPRYLQPSLFAIERLLAIFQA IFPIQGKAESGSLSALREESLMKANIEVFQNLSELHTLKLIATTMNKNIDYLSPKVRW KVNVPWEIIKEISESVHFNISDYFSDIHE" gene complement(156859..157347) /gene="LTO1" /locus_tag="YNL260C" mRNA complement(156859..157347) /gene="LTO1" /locus_tag="YNL260C" /product="ribosome biosynthesis protein LTO1" CDS complement(156859..157347) /gene="LTO1" /locus_tag="YNL260C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23318452|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:26182403]" /experiment="EXISTENCE:direct assay:GO:0062092 Yae1-Lto1 complex [PMID:26182403]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:26182403]" /experiment="EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:26182403]" /experiment="EXISTENCE:mutant phenotype:GO:0062092 Yae1-Lto1 complex [PMID:26182403]" /note="Substrate-specific adaptor protein involved in apo-Rli1p maturation; subunit of the Yae1-Lto1 complex, recruiting apo-Rli1p to the CIA targeting complex, facilitating the insertion of an Fe/S cluster by the Fe-S biosynthetic machinery; deca-GX3 motif crucial for complex formation; essential for aerobic but not anaerobic growth; homolog of human ORAOV1, which is overexpressed in solid tumors; co-expression of ORAOV1 and YAE1 homolog YAE1D1 restores growth and Rli1p maturation after LTO1 depletion" /codon_start=1 /product="ribosome biosynthesis protein LTO1" /protein_id="DAA10299.2" /db_xref="SGD:S000005204" /translation="MDFDNLLNLEEQYYQEGFLEGQNENIKQSFLEGKQYGLQVGFQR FTLLGQMEGLCDVIESYGLHSPTLEKNIHTIRTLMKGLKMNNDDESVMEFERVLIKLK NKFRTILITLHRLVKDKRTPTVTFEVFEDVSRAIAGEIRGFVENEDIAKNKTKQNQAQ SW" gene complement(157644..157865) /gene="ATX1" /locus_tag="YNL259C" mRNA complement(157644..157865) /gene="ATX1" /locus_tag="YNL259C" /product="copper metallochaperone ATX1" CDS complement(157644..157865) /gene="ATX1" /locus_tag="YNL259C" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9083054]" /experiment="EXISTENCE:direct assay:GO:0016531 copper chaperone activity [PMID:9346482|PMID:17961510]" /experiment="EXISTENCE:mutant phenotype:GO:0006825 copper ion transport [PMID:9083054]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:9083054]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:7731983]" /note="Cytosolic copper metallochaperone; transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake; human homolog ATOX1 can complement yeast atx1 mutant; overexpression of human ATOX1 suppresses lysine auxotrophy of the yeast sod1 null mutant, as does overexpression of yeast ATX1" /codon_start=1 /product="copper metallochaperone ATX1" /protein_id="DAA10300.1" /db_xref="SGD:S000005203" /translation="MAEIKHYQFNVVMTCSGCSGAVNKVLTKLEPDVSKIDISLEKQL VDVYTTLPYDFILEKIKKTGKEVRSGKQL" gene complement(158109..160373) /gene="DSL1" /locus_tag="YNL258C" /gene_synonym="RNS1" mRNA complement(158109..160373) /gene="DSL1" /locus_tag="YNL258C" /gene_synonym="RNS1" /product="Dsl1p" CDS complement(158109..160373) /gene="DSL1" /locus_tag="YNL258C" /gene_synonym="RNS1" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15942868]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11739780]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0070939 Dsl1/NZR complex [PMID:19151722]" /experiment="EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:11493604]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:11739780|PMID:11493604]" /experiment="EXISTENCE:mutant phenotype:GO:0032581 ER-dependent peroxisome organization [PMID:19346454]" /experiment="EXISTENCE:physical interaction:GO:0070939 Dsl1/NZR complex [PMID:15958492]" /note="Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; mediates Sey1p-independent homotypic ER fusion; forms Dsl1 tethering complex with Sec39p and Tip20p that forms a stable complex with ER SNAREs Sec20p, Ufe1p and Use1p and is functionally conserved from yeast to mammalian cells; component of the ER target site that interacts with coatomer; interacts with different subunits of COPI vesicle coat; interacts with Cin5p; homolog of fly and human ZW10 gene" /codon_start=1 /product="Dsl1p" /protein_id="DAA10301.1" /db_xref="SGD:S000005202" /translation="MESLFPNKGEIIRELLKDPLILKNDSKRSNGSELELDSSDLLQR EAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMRNNAAYLKQSF NFQQSISTYVDTLHLELVSTLYKILTNGFWKITENSIQFTPTVEWGKDKVHIEYDTFM DFVAQQYFPKGSLDNQAWFILDMTSADSQEQVRAKLNTIMKEYMNLSRIVSMIKNSIF ISGKEISYENEKNILVFSKSSSHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYEL GPLFNTEFTKFVKNNASIILESLDSPLKNLVSVINNKLTRLVAKSEVTNWTHSGKEIQ DLLMNKQLYYNLLLDKVLESHISEIRSIFEDPKKSWQNLEVVELTTSNTNTMSEKIGK NDSDVQNEKELHNAVSKDDDWNWEVEDDDADAWGDEIDVNIDDEEEKTNQEKEKEPEE EENAWDEAWAIDENIDDASLENGKEHLKAHDVGSLDKDHIEVTQLPKLFLAISQNFKS SFADSHVDEQYFAYKYNLLQTSYMAMCTANFSHNWCQLYVDMRYLIERDEKLYRIKEL TRNLLETKLNMKYRIVCQLIRHQLTEFRENERNPSWDATIEKLLPYILKEIVRPLQKI RGEEGSRYLLSFLNFLYNDCVTKEILKWQIISEVNSENLGELVSLLVNNTDIQLLAKE PSYKKMREKFATMGKFLPLHLKEIMEMFYNGDFYLFATDELIQWIELLFADTPLRRNA IDDIYEIRGTALDD" gene complement(160631..164320) /gene="SIP3" /locus_tag="YNL257C" /gene_synonym="LAM3" mRNA complement(160631..164320) /gene="SIP3" /locus_tag="YNL257C" /gene_synonym="LAM3" /product="Sip3p" CDS complement(160631..164320) /gene="SIP3" /locus_tag="YNL257C" /gene_synonym="LAM3" /experiment="EXISTENCE:direct assay:GO:0003712 transcription coregulator activity [PMID:8127709]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:26001273]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8127709]" /experiment="EXISTENCE:mutant phenotype:GO:0032366 intracellular sterol transport [PMID:26001273]" /note="Putative sterol transfer protein; has a probable role in retrograde transport of sterols from the plasma membrane to the ER; co-localizes to puncta in the cortical ER with Ysp2p; contains GRAM, StART-like (VASt) and two PH-like domains; one of 6 StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; previously identified as a transcription cofactor that interacts with DNA-bound Snf1p" /codon_start=1 /product="Sip3p" /protein_id="DAA10302.1" /db_xref="SGD:S000005201" /translation="MSVHGRDPKKRQLRLISVAFKEASIDSPSFRASVNFFQTRVDAL EDWIEKTVDFFDQKYKVSFEDFRRAKETLLSQLLPPPALLSNGFVSNQSFTPRLIDSF NKDYYDFSMKLLQIVKGDDSSHSTALLELMTTAIEPYRNVRKNFDFYQGKYDSMLASY QAIRISKTSLEPSSIKSDALQLFEVQKNYLKASLDLISAISAVKLSLDKFILESMKVL KSRSIFITKDSGRKIDLSPCINEYLDNYAIWVENSIEGSKVLDSDISNAKKQAYRYTL KRITPSSDTSDYNIRSIHSSKLLSKDTQVPPKSPEKSGWLYMKTQVGKPTREIWVRRW CFLKNAVFGMFLLSPSKTYVEETDKFGVFLTNVRYDPEEDRKFCFEVKIFGNKVTEAH DNMSKDITLVFQTSNYLDLKSWLIAFEATKKYVMSIQHDSLEYELAFKRFSPKFFEFA SSTTTSIDQLITTFDKETESLYETLNCSISEYDILTLGEEKVFQFQMPTTPISTKMTQ LAILSNFLTKGSWFPNAVLANIWGTTDWSEYTILPGKGKKPSSLLTIDGKRLPIRNST IYPQYYSNELKVLDLQFKSLVFSPDQRLEKLPEELLLFKFEALWCPNKKQKFSATCFC TKDYIYCYMNSMEFICLTKISLSEIVSVEADRSSKKTLKLYDASGLQMKAIVLFSDYK LIASKLQYLLENKAIKNPNSNEEILVKFEQMEKESQEKKQEELYKIEQENSFDRKATS VSKIIKSRVTFWEMSDDASTLLNRLKKLQTEYSITYNHEYEISSKGLAHILFGDKSNA FPKCLFLARKDGEEHGKRFWYKNKDINGKSQLVRKIPFRLDMTGNFLNTGKYHRDKES KMIFATQRIVKIVDNKYYEVDLDPFFVKVPFCHLLKLSIKFVITESYDVDNHLEIKLN MTASSSSLHVLYKLEYIDSRTGKTIEKLSLAEIICQTWALKFAHSEFLLIRRVLRYYL EKIGKHGKVIKAIKLCGILGVLSNKSEEPATEKNGNSKESESMQYDIRYSCTILFLVF IKLMVYRVTNLTFVFFRILIGILLLCAEKFSRINRMMVVGLLASIMINILLSEKASVP YWSIKRAEKLFHDRLGSDKFTMQRAIYISDSDLLSSQLSVPSNNPIFEKFSEDNFNKD YQYSETRKQLAMRRNELLIELRILQDMEKQLVHDDYEKFLLEEVNKCSMVSIEMTDLW FNDTQLQNYCSICNEELEKLRPPIT" gene 164623..167097 /gene="FOL1" /locus_tag="YNL256W" mRNA 164623..167097 /gene="FOL1" /locus_tag="YNL256W" /product="trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1" CDS 164623..167097 /gene="FOL1" /locus_tag="YNL256W" /EC_number="2.5.1.15" /EC_number="2.7.6.3" /EC_number="4.1.2.25" /experiment="EXISTENCE:direct assay:GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity [PMID:15169867]" /experiment="EXISTENCE:direct assay:GO:0004150 dihydroneopterin aldolase activity [PMID:15169867]" /experiment="EXISTENCE:direct assay:GO:0004156 dihydropteroate synthase activity [PMID:15169867]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8813764]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005740 mitochondrial envelope [PMID:15169867]" /experiment="EXISTENCE:mutant phenotype:GO:0004156 dihydropteroate synthase activity [PMID:11731153]" /experiment="EXISTENCE:mutant phenotype:GO:0046654 tetrahydrofolate biosynthetic process [PMID:15169867|PMID:11731153]" /note="Multifunctional enzyme of the folic acid biosynthesis pathway; has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities" /codon_start=1 /product="trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1" /protein_id="DAA10303.1" /db_xref="SGD:S000005200" /translation="MSKLFSTVNSARHSVPLGGMRDYVHIKKLEMNTVLGPDSWNQLM PQKCLLSLDMGTDFSKSAATDDLKYSLNYAVISRDLTNFVSKKKNWGSVSNLAKSVSQ FVMDKYSGVECLNLEVQADTTHIRSDHISCIIQQERGNPESQEFDVVRISELKMLTLI GVFTFERLKKQYVTLDIKLPWPKKAELPPPVQSIIDNVVKFVEESNFKTVEALVESVS AVIAHNEYFQKFPDSPLVVKVLKLNAITATEGVGVSCIREPREIAMVNIPYLSSIHES SDIKFQLSSSQNTPIEGKNTWKRAFLAFGSNIGDRFKHIQMALQLLSREKTVKLRNIS SIFESEPMYFKDQTPFMNGCVEVETLLTPSELLKLCKKIEYEELQRVKHFDNGPRTID LDIVMFLNSAGEDIIVNEPDLNIPHPRMLERTFVLEPLCELISPVHLHPVTAEPIVDH LKQLYDKQHDEDTLWKLVPLPYRSGVEPRFLKFKTATKLDEFTGETNRITVSPTYIMA IFNATPDSFSDGGEHFADIESQLNDIIKLCKDALYLHESVIIDVGGCSTRPNSIQASE EEEIRRSIPLIKAIRESTELPQDKVILSIDTYRSNVAKEAIKVGVDIINDISGGLFDS NMFAVIAENPEICYILSHTRGDISTMNRLAHYENFALGDSIQQEFVHNTDIQQLDDLK DKTVLIRNVGQEIGERYIKAIDNGVKRWQILIDPGLGFAKTWKQNLQIIRHIPILKNY SFTMNSNNSQVYVNLRNMPVLLGPSRKKFIGHITKDVDAKQRDFATGAVVASCIGFGS DMVRVHDVKNCSKSIKLADAIYKGLE" gene complement(167329..167790) /gene="GIS2" /locus_tag="YNL255C" mRNA complement(167329..167790) /gene="GIS2" /locus_tag="YNL255C" /product="mRNA-binding translational activator GIS2" CDS complement(167329..167790) /gene="GIS2" /locus_tag="YNL255C" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:23285195|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:21232131]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21232131|PMID:23222640|PMID:20844764]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23285195]" /experiment="EXISTENCE:direct assay:GO:0045182 translation regulator activity [PMID:21277287]" /experiment="EXISTENCE:direct assay:GO:2000767 positive regulation of cytoplasmic translation [PMID:21277287]" /note="Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2" /codon_start=1 /product="mRNA-binding translational activator GIS2" /protein_id="DAA10304.1" /db_xref="SGD:S000005199" /translation="MSQKACYVCGKIGHLAEDCDSERLCYNCNKPGHVQTDCTMPRTV EFKQCYNCGETGHVRSECTVQRCFNCNQTGHISRECPEPKKTSRFSKVSCYKCGGPNH MAKDCMKEDGISGLKCYTCGQAGHMSRDCQNDRLCYNCNETGHISKDCPKA" gene complement(168043..169248) /gene="RTC4" /locus_tag="YNL254C" mRNA complement(168043..169248) /gene="RTC4" /locus_tag="YNL254C" /product="Rtc4p" CDS complement(168043..169248) /gene="RTC4" /locus_tag="YNL254C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus" /codon_start=1 /product="Rtc4p" /protein_id="DAA10305.1" /db_xref="SGD:S000005198" /translation="MVGPGLGINRVRRKGVYSTKKGSGDNLLLMKRQGKHDIHDRESD DLSGHDAFSPSKKRGKIDSITEDEIEVKKLSTVATFDKLSRSFPNSEVQAAKNAALRG KEKEEEKVVSIPLIQNLKNEDIESIKCRNNNLLDGKKLLLEAELSAVEDNQIFSSSFP EDKKLSLQSCLSSKEQIIKKLQVREEYMSKFKLPPMLFSDELLTEVEPFMPIVMDILE GKISSVYYFEAKNAFKNSQKAYLSVDEFRKLNLNKFTAGFYGLKRQLRVGEEIAKRYK RALTHNQPATLKWWGITDFCNYVLAPETLTSFCIYQLNLSNKSCSSKTPNKHPKQQLN EKEYYYDPELRMLAYDLLEDTVEYGIIVADSDPIEQWEAAIEEDRLRELKLDVHNYSS RRWRLDTHD" rep_origin 169675..169753 /note="ARS1411; ARS activated in late S phase" /db_xref="SGD:S000077373" gene 170018..171286 /gene="TEX1" /locus_tag="YNL253W" mRNA 170018..171286 /gene="TEX1" /locus_tag="YNL253W" /product="Tex1p" CDS 170018..171286 /gene="TEX1" /locus_tag="YNL253W" /experiment="EXISTENCE:curator inference:GO:0006406 mRNA export from nucleus [PMID:11979277]" /experiment="EXISTENCE:direct assay:GO:0000346 transcription export complex [PMID:11979277]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /note="Protein involved in mRNA export; component of the transcription export (TREX) complex" /codon_start=1 /product="Tex1p" /protein_id="DAA10306.1" /db_xref="SGD:S000005197" /translation="MSTIGAVDILNQKTITSEVAASVTSKYLQSTFSKGNTSHIEDKR FIHVSSRSHSRFTSTPITPNEILSLKFHVSGSSMAYSRMDGSLTVWFIKDASFDKSVE VYIPDCCGSDKLATDLSWNPTSLNQIAVVSNSSEISLLLINEKSLTASKLRTLSLGSK TKVNTCLYDPLGNWLLAATKSEKIYLFDVKKDHSSVCSLNISDISQEDNDVVYSLAWS NGGSHIFIGFKSGYLAILKAKHGILEVCTKIKAHTGPITEIKMDPWGRNFITGSIDGN CYVWNMKSLCCELIINDLNSAVTTLDVCHLGKILGICTEDEMVYFYDLNSGNLLHSKS LANYKTDPVLKFYPDKSWYIMSGKNDTLSNHFVKNEKNLITYWKDMFDNTMIEKRRKN NGGGNNHNKRTSKNTDRIGKDRPSRFNSKK" gene complement(171441..172286) /gene="MRPL17" /locus_tag="YNL252C" /gene_synonym="mL46" /gene_synonym="MRPL30" mRNA complement(171441..172286) /gene="MRPL17" /locus_tag="YNL252C" /gene_synonym="mL46" /gene_synonym="MRPL30" /product="mitochondrial 54S ribosomal protein YmL17/YmL30" CDS complement(171441..172286) /gene="MRPL17" /locus_tag="YNL252C" /gene_synonym="mL46" /gene_synonym="MRPL30" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552|PMID:9151978]" /note="Mitochondrial ribosomal protein of the large subunit" /codon_start=1 /product="mitochondrial 54S ribosomal protein mL46 MRPL17" /protein_id="DAA10307.1" /db_xref="SGD:S000005196" /translation="MKVNLMLKRGLATATATASSAPPKIKVGVLLSRIPIIKSELNEL EKKYYEYQSELEKRLMWTFPAYFYFKKGTVAEHKFLSLQKGPISKKNGIWFPRGIPDI KHGRERSTKQEVKLSDDSTVAFSNNQKEQSKDDVNRPVIPNDRITEADRSNDMKSLER QLSRTLYLLVKDKSGTWKFPNFDLSDESKPLHVHAENELKLLSGDQIYTWSVSATPIG VLQDERNRTAEFIVKSHILAGKFDLVASKNDAFEDFAWLTKGEISEYVPKDYFNKTEF LLADN" gene complement(172588..174315) /gene="NRD1" /locus_tag="YNL251C" mRNA complement(172588..174315) /gene="NRD1" /locus_tag="YNL251C" /product="Nrd1 complex RNA-binding subunit" CDS complement(172588..174315) /gene="NRD1" /locus_tag="YNL251C" /experiment="EXISTENCE:direct assay:GO:0001068 transcription regulatory region RNA binding [PMID:21084293]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:9618475]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0019904 protein domain specific binding [PMID:18660819]" /experiment="EXISTENCE:direct assay:GO:0030847 termination of RNA polymerase II transcription, exosome-dependent [PMID:16427013]" /experiment="EXISTENCE:direct assay:GO:0035649 Nrd1 complex [PMID:10655211]" /experiment="EXISTENCE:direct assay:GO:0071041 antisense RNA transcript catabolic process [PMID:27190003]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:11565036]" /experiment="EXISTENCE:mutant phenotype:GO:0031126 sno(s)RNA 3'-end processing [PMID:11565036]" /experiment="EXISTENCE:mutant phenotype:GO:0034472 snRNA 3'-end processing [PMID:11565036]" /experiment="EXISTENCE:mutant phenotype:GO:0042780 tRNA 3'-end processing [PMID:21460797]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:21113025]" /experiment="EXISTENCE:mutant phenotype:GO:0071034 CUT catabolic process [PMID:16973436]" /experiment="EXISTENCE:mutant phenotype:GO:0071041 antisense RNA transcript catabolic process [PMID:22028667]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27076633]" /note="RNA-binding subunit of Nrd1 complex; complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with CTD of RNA pol II large subunit Rpo21p at phosphorylated Ser5 to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites; role in regulation of mitochondrial abundance and cell size" /codon_start=1 /product="Nrd1 complex RNA-binding subunit" /protein_id="DAA10308.1" /db_xref="SGD:S000005195" /translation="MQQDDDFQNFVATLESFKDLKSGISGSRIKKLTTYALDHIDIES KIISLIIDYSRLCPDSHKLGSLYIIDSIGRAYLDETRSNSNSSSNKPGTCAHAINTLG EVIQELLSDAIAKSNQDHKEKIRMLLDIWDRSGLFQKSYLNAIRSKCFAMDISNNTAN TASQQLSLDPKQRSKQILSNLKKSPPLNLNISLPTDLTSTDPAKQQAALFQVIAALQK HFKTLPSHTSVGTVAPPQAHTITEYGSRRERERERERYNSRRNRSRSPPAPFSQPSTG RKDRYPSVAQDQYSIGAPNTTFGTNNHHLYPDELNVSNNPHYRPKPVSYDSTLPPDHI KVYSRTLFIGGVPLNMKEWDLANVLKPFAEVQSVILNNSRKHAFVKVYSRHEAENVLQ NFNKDGALPLRTRWGVGFGPRDCCDYQHGYSIIPMHRLTDADKKWSVSAQWGGTSGQP LVTGIVFEEPDIIVGEGVSSKAISQKMPTDSGRNGPRSGKPNKSGSISSISPVPYGNA PLASPPPQQYVQPMMQQPYGYAPNQPLPSQGPAAAAPPVPQQQFDPTAQLNSLMNMLN QQQQQQQQS" gene 175410..179348 /gene="RAD50" /locus_tag="YNL250W" mRNA 175410..179348 /gene="RAD50" /locus_tag="YNL250W" /product="MRX complex DNA-binding subunit" CDS 175410..179348 /gene="RAD50" /locus_tag="YNL250W" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:8367302]" /experiment="EXISTENCE:direct assay:GO:0003691 double-stranded telomeric DNA binding [PMID:17698079]" /experiment="EXISTENCE:direct assay:GO:0004017 AMP kinase activity [PMID:17349953]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:9845372]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:15546877]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:15721260]" /experiment="EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:17698079]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:17698079]" /experiment="EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:11238918]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:17349953]" /experiment="EXISTENCE:mutant phenotype:GO:0004017 AMP kinase activity [PMID:17349953]" /experiment="EXISTENCE:mutant phenotype:GO:0006284 base-excision repair [PMID:20040573]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:31390569|PMID:9501103|PMID:12399380]" /experiment="EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:8207053]" /experiment="EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:27173583]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:17349953]" /experiment="EXISTENCE:mutant phenotype:GO:0097552 mitochondrial double-strand break repair via homologous recombination [PMID:22214610]" /experiment="EXISTENCE:physical interaction:GO:0030870 Mre11 complex [PMID:9845372]" /note="Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress" /codon_start=1 /product="MRX complex DNA-binding subunit" /protein_id="DAA10309.1" /db_xref="SGD:S000005194" /translation="MSAIYKLSIQGIRSFDSNDRETIEFGKPLTLIVGMNGSGKTTII ECLKYATTGDLPPNSKGGVFIHDPKITGEKDIRAQVKLAFTSANGLNMIVTRNIQLLM KKTTTTFKTLEGQLVAINNSGDRSTLSTRSLELDAQVPLYLGVPKAILEYVIFCHQED SLWPLSEPSNLKKKFDEIFQAMKFTKALDNLKSIKKDMSVDIKLLKQSVEHLKLDKDR SKAMKLNIHQLQTKIDQYNEEVSEIESQLNEITEKSDKLFKSNQDFQKILSKVENLKN TKLSISDQVKRLSNSIDILDLSKPDLQNLLANFSKVLMDKNNQLRDLETDISSLKDRQ SSLQSLSNSLIRRQGELEAGKETYEKNRNHLSSLKEAFQHKFQGLSNIENSDMAQVNH EMSQFKAFISQDLTDTIDQFAKDIQLKETNLSDLIKSITVDSQNLEYNKKDRSKLIHD SEELAEKLKSFKSLSTQDSLNHELENLKTYKEKLQSWESENIIPKLNQKIEEKNNEMI ILENQIEKFQDRIMKTNQQADLYAKLGLIKKSINTKLDELQKITEKLQNDSRIRQVFP LTQEFQRADLEMDFQKLFINMQKNIAINNKKMHELDRRYTNALYNLNTIEKDLQDNQK SKEKVIQLLSENLPEDCTIDEYNDVLEETELSYKTALENLKMHQTTLEFNRKALEIAE RDSCCYLCSRKFENESFKSKLLQELKTKTDANFEKTLKDTVQNEKEYLHSLRLLEKHI ITLNSINEKIDNSQKCLEKAKEETKTSKSKLDELEVDSTKLKDEKELAESEIRPLIEK FTYLEKELKDLENSSKTISEELSIYNTSEDGIQTVDELRDQQRKMNDSLRELRKTISD LQMEKDEKVRENSRMINLIKEKELTVSEIESSLTQKQNIDDSIRSKRENINDIDSRVK ELEARIISLKNKKDEAQSVLDKVKNERDIQVRNKQKTVADINRLIDRFQTIYNEVVDF EAKGFDELQTTIKELELNKAQMLELKEQLDLKSNEVNEEKRKLADSNNEEKNLKQNLE LIELKSQLQHIESEISRLDVQNAEAERDKYQEESLRLRTRFEKLSSENAGKLGEMKQL QNQIDSLTHQLRTDYKDIEKNYHKEWVELQTRSFVTDDIDVYSKALDSAIMKYHGLKM QDINRIIDELWKRTYSGTDIDTIKIRSDEVSSTVKGKSYNYRVVMYKQDVELDMRGRC SAGQKVLASIIIRLALSETFGANCGVIALDEPTTNLDEENIESLAKSLHNIINMRRHQ KNFQLIVITHDEKFLGHMNAAAFTDHFFKVKRDDRQKSQIEWVDINRVTY" gene complement(179394..181022) /gene="MPA43" /locus_tag="YNL249C" mRNA complement(179394..181022) /gene="MPA43" /locus_tag="YNL249C" /product="Mpa43p" CDS complement(179394..181022) /gene="MPA43" /locus_tag="YNL249C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /codon_start=1 /product="Mpa43p" /protein_id="DAA10310.1" /db_xref="SGD:S000005193" /translation="MNSSLQVGIGIDVGSSSARIGVYNYYNDALLEMAQEPVPYYQDS SKKSWKFWQKSTEIIKALQKCLQKLNIREYEVKSCGVSATCSLAIFERDRTSNMLIPY PNEDNVIFWMDSSAVNECQWLNMQCPQQLLDYLGGKFVPEMGVPKLKYFLDEYSHLRD KHFHIFDLHQYIAYELSRLYEWNIEGLLGRENLNGIGNDGEVSGWSSSFYKNIINLPS NVSIGTTSLVANKHISTTVVRSCIDSYASWFAVASPHLETSLFMIAGTSSCYMYGTTI SDTRIPGVWGPFDTILDNRGDFSVYAAGQSCTGKLIEHLFESHPCARKILKDGADIYQ VLEQTIRDIEKNNGLSIHILTKDMFFYGDYEGNRTPFADPRIKGSFIGESTDTSMLNL TYKYICILEFLSFQTKLIIDTFQNENSNIHIKELRISGSQAKNERLLSLISLVNNGVA IIKPKENVDMMGIKGAYVLAKSAKEKKQLADVITERDISNDSEKFESLAEYRLGNDSI LLRKLLCVKYHIHLDMAKQQKRYHKLVDEVFQHL" gene complement(181361..182608) /gene="RPA49" /locus_tag="YNL248C" mRNA complement(181361..182608) /gene="RPA49" /locus_tag="YNL248C" /product="DNA-directed RNA polymerase I subunit RPA49" CDS complement(181361..182608) /gene="RPA49" /locus_tag="YNL248C" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:21263028]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0006362 transcription elongation by RNA polymerase I [PMID:18160037]" /experiment="EXISTENCE:genetic interaction:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:9121426]" /experiment="EXISTENCE:mutant phenotype:GO:0005736 RNA polymerase I complex [PMID:1409638]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:12374750]" /note="RNA polymerase I subunit A49; essential for nucleolar assembly and for high polymerase loading rate; required for nucleolar localization of Rpa34p" /codon_start=1 /product="DNA-directed RNA polymerase I subunit RPA49" /protein_id="DAA10311.1" /db_xref="SGD:S000005192" /translation="MSVKRSVSEIEIESVQDQPSVAVGSFFKGFRAPSDTTFDLYKKK KSEKDEFVLHGENERLEYEGYTDSSSQASNQYVVGLFNPEKKSIQLYKAPVLVSKVVS KSSKNLRGPKIKSKSDTRPSALRNALGEAFGTKKAKKAIADLERNRIDSDKLTDSAID IVDSVRTASKDLPTRAQLDEITSNDRPTPLANIDATDVEQIYPIESIIPKKELQFIRV SSILKEADKEKKLELFPYQNNSKYVAKKLDSLTQPSQMTKLQLLYYLSLLLGVYENRR VNNKTKLLERLNSPPEILVDGILSRFTVIKPGQFGRSKDRSYFIDPQNEDKILCYILA IIMHLDNFIVEITPLAHELNLKPSKVVSLFRVLGAIVKGATVAQAEAFGIPKSTAASY KIATMKVPFKLPEMTRRGRGPRR" gene 182875..185178 /gene="CRS1" /locus_tag="YNL247W" mRNA 182875..185178 /gene="CRS1" /locus_tag="YNL247W" /product="cysteine--tRNA ligase" CDS 182875..185178 /gene="CRS1" /locus_tag="YNL247W" /EC_number="6.1.1.16" /experiment="EXISTENCE:direct assay:GO:0004817 cysteine-tRNA ligase activity [PMID:9523015]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:31350340]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:31350340]" /experiment="EXISTENCE:direct assay:GO:0006423 cysteinyl-tRNA aminoacylation [PMID:9523015]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /note="Cysteinyl-tRNA synthetase; CRS1 has two in-frame start codons resulting in a shorter isoform that is retained in the cytosol and a longer form that is mitochondrial; may interact with ribosomes, based on co-purification experiments; human gene CARS allows growth of the yeast haploid null mutant after sporulation of a heterozygous diploid" /codon_start=1 /product="cysteine--tRNA ligase" /protein_id="DAA10312.1" /db_xref="SGD:S000005191" /translation="MNIFIKALRRYTIMSTPKIVQPKWKVPTPQAKETVLKLYNSLTR SKVEFIPQSGNRGVTWYSCGPTVYDASHMGHARNYVSIDINRRIIQDYFGYDVQFVQN VTDIDDKIILRARQNYLFDNFVKENDTKFNATVVDKVKTALFQYINKNFTIQGSEIKT IEEFETWLSNADTETLKLENPKFPMHVTAVQNAIESITKGDSMDAEVAFEKVKDVTVP LLDKELGSTISNPEIFRQLPAYWEQKFNDDMLSLNVLPPTVTTRVSEYVPEIIDFVQK IIDNGYAYATSDGSVYFDTLKFDKSPNHDYAKCQPWNKGQLDLINDGEGSLSNFADNG KKSNNDFALWKASKAGEPEWESPWGKGRPGWHIECSVMASDILGSNIDIHSGGIDLAF PHHDNELAQSEARFDNQQWINYFLHTGHLHIEGQKMSKSLKNFITIQEALKKFSPRQL RLAFASVQWNNQLDFKESLIHEVKSFENSMNNFFKTIRALKNDAASAGHISKKFSPLE KELLADFVESESKVHSAFCDNLSTPVALKTLSELVTKSNTYITTAGAALKIEPLIAIC SYITKILRIIGFPSRPDNLGWAAQAGSNDGSLGSLEDTVMPYVKCLSTFRDDVRSLAI KKAEPKEFLQLTDKIRNEDLLNLNVALDDRNGQSALIKFLTNDEKLEIVKLNEEKHAN ELAKKQKKLEQQKLREQKENERKQKAQIKPQDMFKDVTLYSAWDEQGLPTKDKDGNDI TKSMTKKLKKQWEQQKKLHEEYFGEDK" gene 185460..186349 /gene="VPS75" /locus_tag="YNL246W" mRNA join(185460..185491,185587..186349) /gene="VPS75" /locus_tag="YNL246W" /product="Vps75p" CDS join(185460..185491,185587..186349) /gene="VPS75" /locus_tag="YNL246W" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:17344218]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006334 nucleosome assembly [PMID:17344218]" /experiment="EXISTENCE:direct assay:GO:0010698 acetyltransferase activator activity [PMID:19172749]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:17344218]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:18036332]" /experiment="EXISTENCE:mutant phenotype:GO:0010698 acetyltransferase activator activity [PMID:19172749]" /experiment="EXISTENCE:physical interaction:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:18036332]" /experiment="EXISTENCE:physical interaction:GO:0042393 histone binding [PMID:17344218]" /note="NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia" /codon_start=1 /product="Vps75p" /protein_id="DAA10313.1" /db_xref="SGD:S000005190" /translation="MMSDQENENEHAKAFLGLAKCEEEVDAIEREVELYRLNKMKPVY EKRDAYIDEIAEFWKIVLSQHVSFANYIRASDFKYIDTIDKIKVEWLALESEMYDTRD FSITFHFHGIEGDFKEQQVTKVFQIKKGKDDQEDGILTSEPVPIEWPQSYDSINPDLI KDKRSPEGKKKYRQGMKTIFGWFRWTGLKPGKEFPHGDSLASLFSEEIYPFCVKYYAE AQRDLEDEEGESGLSADGDSEDDDGSLGEVDLPLSDEEPSSKKRKV" gene complement(186346..186885) /gene="CWC25" /locus_tag="YNL245C" mRNA complement(186346..186885) /gene="CWC25" /locus_tag="YNL245C" /product="U2-type spliceosomal complex subunit CWC25" CDS complement(186346..186885) /gene="CWC25" /locus_tag="YNL245C" /experiment="EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:19935684]" /experiment="EXISTENCE:direct assay:GO:0005684 U2-type spliceosomal complex [PMID:11884590]" /note="Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p" /codon_start=1 /product="U2-type spliceosomal complex subunit CWC25" /protein_id="DAA10314.1" /db_xref="SGD:S000005189" /translation="MGSGDLNLLKSWNPKLMKNRKKVWETEQDLITEQQKLNTRLKEI EKERELNELLNESSKDKPETLKNDLALKKSGLEWMYQDAKLSDEKEDYLLGKKKLDSS ILNQPATPPVRAATTISASGAATSISSQKKKSKLLKDDPMSKFKVTKQQRRTPDSTKK RAMSQRGKPLSKPAPDLDY" gene complement(187170..187496) /gene="SUI1" /locus_tag="YNL244C" /gene_synonym="MOF2" /gene_synonym="RFR1" mRNA complement(187170..187496) /gene="SUI1" /locus_tag="YNL244C" /gene_synonym="MOF2" /gene_synonym="RFR1" /product="translation initiation factor eIF1" CDS complement(187170..187496) /gene="SUI1" /locus_tag="YNL244C" /gene_synonym="MOF2" /gene_synonym="RFR1" /experiment="EXISTENCE:direct assay:GO:0001731 formation of translation preinitiation complex [PMID:17434125|PMID:12008673|PMID:15664195|PMID:17504939]" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0016282 eukaryotic 43S preinitiation complex [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0031369 translation initiation factor binding [PMID:12861028|PMID:15145951]" /experiment="EXISTENCE:direct assay:GO:0043024 ribosomal small subunit binding [PMID:12860115|PMID:17434125|PMID:19751744]" /experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF complex [PMID:15838098|PMID:11018020]" /experiment="EXISTENCE:mutant phenotype:GO:0001731 formation of translation preinitiation complex [PMID:19751744|PMID:17504939]" /experiment="EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:19751744]" /experiment="EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:9488467]" /experiment="EXISTENCE:physical interaction:GO:0031369 translation initiation factor binding [PMID:15145951|PMID:22851688|PMID:12861028]" /note="Translation initiation factor eIF1; component of complex involved in recognition of initiator codon; modulates translation accuracy at initiation phase by discriminating against suboptimal initiation sites to prevent excessive uORF translation genome-wide" /codon_start=1 /product="translation initiation factor eIF1" /protein_id="DAA10315.1" /db_xref="SGD:S000005188" /translation="MSIENLKSFDPFADTGDDETATSNYIHIRIQQRNGRKTLTTVQG VPEEYDLKRILKVLKKDFACNGNIVKDPEMGEIIQLQGDQRAKVCEFMISQLGLQKKN IKIHGF" gene 188051..190957 /gene="SLA2" /locus_tag="YNL243W" /gene_synonym="END4" /gene_synonym="MOP2" mRNA 188051..190957 /gene="SLA2" /locus_tag="YNL243W" /gene_synonym="END4" /gene_synonym="MOP2" /product="Sla2p" CDS 188051..190957 /gene="SLA2" /locus_tag="YNL243W" /gene_synonym="END4" /gene_synonym="MOP2" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11302750]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:10397764]" /experiment="EXISTENCE:direct assay:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:17151356]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:mutant phenotype:GO:0000147 actin cortical patch assembly [PMID:8335689]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8380177]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:10397764]" /note="Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo" /codon_start=1 /product="Sla2p" /protein_id="DAA10316.2" /db_xref="SGD:S000005187" /translation="MSRIDSDLQKALKKACSVEETAPKRKHVRACIVYTWDHQSSKAV FTTLKTLPLANDEVQLFKMLIVLHKIIQEGHPSALAEAIRDRDWIRSLGRVHSGGSSY SKLIREYVRYLVLKLDFHAHHRGFNNGTFEYEEYVSLVSVSDPDEGYETILDLMSLQD SLDEFSQIIFASIQSERRNTECKISALIPLIAESYGIYKFITSMLRAMHRQLNDAEGD AALQPLKERYELQHARLFEFYADCSSVKYLTTLVTIPKLPVDAPDVFLINDVDESKEI KFKKREPSVTPARTPARTPTPTPPVVAEPAISPRPVSQRTTSTPTGYLQTMPTGATTG MMIPTATGAANAIFPQATAQMQPDFWANQQAQFANEQNRLEQERVQQLQQQQAQQELF QQQLQKAQQDMMNMQLQQQNQHQNDLIALTNQYEKDQALLQQYDQRVQQLESEITTMD STASKQLANKDEQLTALQDQLDVWERKYESLAKLYSQLRQEHLNLLPRFKKLQLKVNS AQESIQKKEQLEHKLKQKDLQMAELVKDRDRARLELERSINNAEADSAAATAAAETMT QDKMNPILDAILESGINTIQESVYNLDSPLSWSGPLTPPTFLLSLLESTSENATEFAT SFNNLIVDGLAHGDQTEVIHCVSDFSTSMATLVTNSKAYAVTTLPQEQSDQILTLVKR CAREAQYFFEDLMSENLNQVGDEEKTDIVINANVDMQEKLQELSLAIEPLLNIQSVKS NKETNPHSELVATADKIVKSSEHLRVDVPKPLLSLALMIIDAVVALVKAAIQCQNEIA TTTSIPLNQFYLKNSRWTEGLISAAKAVAGATNVLITTASKLITSEDNENTSPEQFIV ASKEVAASTIQLVAASRVKTSIHSKAQDKLEHCSKDVTDACRSLGNHVMGMIEDDHST SQQQQPLDFTSEHTLKTAEMEQQVEILKLEQSLSNARKRLGEIRRHAYYNQDDD" gene 191324..196102 /gene="ATG2" /locus_tag="YNL242W" /gene_synonym="APG2" /gene_synonym="AUT8" /gene_synonym="SPO72" mRNA 191324..196102 /gene="ATG2" /locus_tag="YNL242W" /gene_synonym="APG2" /gene_synonym="AUT8" /gene_synonym="SPO72" /product="Atg2p" CDS 191324..196102 /gene="ATG2" /locus_tag="YNL242W" /gene_synonym="APG2" /gene_synonym="AUT8" /gene_synonym="SPO72" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:18497569|PMID:11689437]" /experiment="EXISTENCE:direct assay:GO:0000425 pexophagy [PMID:11382760]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:11382760]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:27498190]" /experiment="EXISTENCE:direct assay:GO:0061908 phagophore [PMID:23549786]" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:11382761]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:11382760]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:23382696]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:11382761]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /experiment="EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:26181331]" /note="Putative lipid transport protein; peripheral membrane protein required for vesicle formation during autophagy, pexophagy and the CVT pathway; directed to autophagic membranes by Atg18p where it acts as a PAS-ER membrane tether during autophagosome formation; involved in Atg9p cycling between the PAS and mitochondria; binds the phospholipid PI(3)P via an APT1 domain; essential for cell cycle progression from G2/M to G1 under nitrogen starvation; forms cytoplasmic foci upon DNA replication stress" /codon_start=1 /product="Atg2p" /protein_id="DAA10317.1" /db_xref="SGD:S000005186" /translation="MAFWLPQNIQKRLLLYVLQQISLFSNIDLSNLDVSIGSKSHFSF HDVNLSLDDLNIPNVQINEGIVDELVLKLTVSGGVEIDGSGLRFIMTPLYSSGSQELH SDFLVKSIQDLTNSMLQFSDPLTTYNRYKEDDISSSDSSSDLNSNIEASKPAANGSYT LQNMRNKALNVALAKLKIALKDVTIRFIVNDRDPSDNIVEVHLESIQLITTDANLRHI NIENITISSIQKQAVPDSPVHPFNNDDLSQSVYLSKMEATSLYMSAMEEQSNEDPSEP QVTQEEQENDKCKESLMEINNLNIAFKGLSSVNDLRMSNIVIDIQDVHLAIHKIVEIK NSTLKNIIDIIVTHLDANESFSCQDSQSPSPDKQEPSALSSVDIKCIYLNLGQDITVI LKSFKLEQKENNSLAFSLGSFYSNSSPLTISHKTKPLLTGEQTPQSIALNMGDELDII ISHDGIAHFFKIFQFVSKCMSFYQNKSKGMMPQIASDTKRTVQLTSKAVKLSLKFPYF LLCFQVSPFIYDSNRELYIELVDVFKKLPSRCTKILTMSSITISNLQSPLQLGSYDDT LKEALIYSSVHAIIKEVIFNEEYSGIVQLVEDISAFGKLFTDSKNSECTGKSKSKRGS FLQRSVRVLNSSRFVYKQSLSANFSLKIDSMKLKVSEIIGPQFGSVEALLSNNFFAIT DDSQIVYFTKNLKVERKTPSLLEPQEIMSVVLNKAVNEPVLYVHRRANGKLKVIFNNI RIHYYARWLEILKKNIGPDNASSKDEPVSQKLSKKQPTSGFPWELKCLDCSLILHPFR LKSVMVIVLDNLTTGGSSFIPQAKLLSKANTLFLIDDYQNFKIQKDKNWPSLINFYAG QGFSAIGKIDTLNFLINKSDGALLLDCKIEQVGLSLCADSFQTFCQLCIDLKYPQTFP DEEKFRTQLKNPIDVFKDIDCDLFNSAFIRENNHQNDYDSVHLVDSFLDKTHEFNNGA RSKLSSQGSYEMDSSSGTATGGILLPHESYLDSAQPKEEDTPPIASKEQERDVDIRGS IDVEKVVIKLFDGYDWKYTRKFIANTVEKLDKELSKAEASSSKSNVPQSEANIFDSIY ISANKNNVTDLRRNLDGEIQGVQNSFSDVSKVNLRPSKHYKALIQLNKVHVNLKNYRV DEPDESNSDNSTDVLNRCVVSIYEFEIIDNVPTSTWNKFVTLLKHEPWPHSSPMFLLD LEFIRPIDFLQAVELVMQLNVAPLRLHVDQDTLEFLIRFLGFKDKRFELIDEYPDIVF IQKFSTNSIKLRLDYKPKKVDYAGLRSGQTSELMNFFTLDGSKIILKSVVLYGLNGFD ELNNKLKAIWTPDITKKQLPGVLEGLAPVRSFMAIGSGVKTLVTVLMSEYRQEGHLGR SLKKGGNVFLKTTTGDFVKLGVKLTSGTQAILENTEELFGGVGSNGRVYDASKFGSAD GADSDTAAVLDLDTLFEEDQLVGSKYSRIRDHEPTAVVIDMSSPGDHNEPTIVSLYAD QPLDLPTGLKEAYSSLEKHMHIAYDAVWRAKGQMKDDKRGGPSAAAVYVARAAPVAII RPLIGATEAVSKTLQGIANQVDKTHNEQINDKYKSNRTDS" rep_origin 196134..196232 /note="ARS1412; ARS activated in late S phase" /db_xref="SGD:S000077374" gene complement(196426..197943) /gene="ZWF1" /locus_tag="YNL241C" /gene_synonym="MET19" /gene_synonym="POS10" mRNA complement(196426..197943) /gene="ZWF1" /locus_tag="YNL241C" /gene_synonym="MET19" /gene_synonym="POS10" /product="glucose-6-phosphate dehydrogenase" CDS complement(196426..197943) /gene="ZWF1" /locus_tag="YNL241C" /gene_synonym="MET19" /gene_synonym="POS10" /EC_number="1.1.1.49" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004345 glucose-6-phosphate dehydrogenase activity [PMID:2269430|PMID:2001672]" /experiment="EXISTENCE:mutant phenotype:GO:0006740 NADPH regeneration [PMID:2269430]" /experiment="EXISTENCE:mutant phenotype:GO:0009051 pentose-phosphate shunt, oxidative branch [PMID:8299150|PMID:7045591]" /experiment="EXISTENCE:mutant phenotype:GO:0042542 response to hydrogen peroxide [PMID:7586028|PMID:9480895]" /note="Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adaptation to oxidative stress; negative regulator of nonselective autophagy, independent of Stb5p; protein abundance increases in response to DNA replication stress; homolog of human G6PD which is deficient in patients with hemolytic anemia; human G6PD can complement yeast zwf1 null mutant" /codon_start=1 /product="glucose-6-phosphate dehydrogenase" /protein_id="DAA10318.1" /db_xref="SGD:S000005185" /translation="MSEGPVKFEKNTVISVFGASGDLAKKKTFPALFGLFREGYLDPS TKIFGYARSKLSMEEDLKSRVLPHLKKPHGEADDSKVEQFFKMVSYISGNYDTDEGFD ELRTQIEKFEKSANVDVPHRLFYLALPPSVFLTVAKQIKSRVYAENGITRVIVEKPFG HDLASARELQKNLGPLFKEEELYRIDHYLGKELVKNLLVLRFGNQFLNASWNRDNIQS VQISFKERFGTEGRGGYFDSIGIIRDVMQNHLLQIMTLLTMERPVSFDPESIRDEKVK VLKAVAPIDTDDVLLGQYGKSEDGSKPAYVDDDTVDKDSKCVTFAAMTFNIENERWEG VPIMMRAGKALNESKVEIRLQYKAVASGVFKDIPNNELVIRVQPDAAVYLKFNAKTPG LSNATQVTDLNLTYASRYQDFWIPEAYEVLIRDALLGDHSNFVRDDELDISWGIFTPL LKHIERPDGPTPEIYPYGSRGPKGLKEYMQKHKYVMPEKHPYAWPVTKPEDTKDN" gene complement(198502..199977) /gene="NAR1" /locus_tag="YNL240C" mRNA complement(198502..199977) /gene="NAR1" /locus_tag="YNL240C" /product="iron-sulfur cluster assembly protein NAR1" CDS complement(198502..199977) /gene="NAR1" /locus_tag="YNL240C" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15103330]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:15103330]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:15103330]" /note="Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery; required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; deficiency results in shortened lifespan and sensitivity to paraquat; homologous to human Narf" /codon_start=1 /product="iron-sulfur cluster assembly protein NAR1" /protein_id="DAA10319.1" /db_xref="SGD:S000005184" /translation="MSALLSESDLNDFISPALACVKPTQVSGGKKDNVNMNGEYEVST EPDQLEKVSITLSDCLACSGCITSSEEILLSSQSHSVFLKNWGKLSQQQDKFLVVSVS PQCRLSLAQYYGLTLEAADLCLMNFFQKHFQCKYMVGTEMGRIISISKTVEKIIAHKK QKENTGADRKPLLSAVCPGFLIYTEKTKPQLVPMLLNVKSPQQITGSLIRATFESLAI ARESFYHLSLMPCFDKKLEASRPESLDDGIDCVITPREIVTMLQELNLDFKSFLTEDT SLYGRLSPPGWDPRVHWASNLGGTCGGYAYQYVTAVQRLHPGSQMIVLEGRNSDIVEY RLLHDDRIIAAASELSGFRNIQNLVRKLTSGSGSERKRNITALRKRRTGPKANSREMA AATAATADPYHSDYIEVNACPGACMNGGGLLNGEQNSLKRKQLVQTLNKRHGEELAMV DPLTLGPKLEEAAARPLSLEYVFAPVKQAVEKDLVSVGSTW" gene 200569..201933 /gene="LAP3" /locus_tag="YNL239W" /gene_synonym="BLH1" /gene_synonym="GAL6" /gene_synonym="YCP1" mRNA 200569..201933 /gene="LAP3" /locus_tag="YNL239W" /gene_synonym="BLH1" /gene_synonym="GAL6" /gene_synonym="YCP1" /product="bleomycin hydrolase" CDS 200569..201933 /gene="LAP3" /locus_tag="YNL239W" /gene_synonym="BLH1" /gene_synonym="GAL6" /gene_synonym="YCP1" /EC_number="3.4.22.40" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:8063738]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:9584198]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:9584198]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:19061865|PMID:9584198|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0008234 cysteine-type peptidase activity [PMID:8063738]" /experiment="EXISTENCE:direct assay:GO:0043418 homocysteine catabolic process [PMID:16769724]" /experiment="EXISTENCE:direct assay:GO:0046677 response to antibiotic [PMID:8063738]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9374524]" /experiment="EXISTENCE:mutant phenotype:GO:0043418 homocysteine catabolic process [PMID:16769724]" /note="Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; cytosolic protein, selectively transported to vacuole during nitrogen starvation; targeted to vacuole via CVT pathway; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH" /codon_start=1 /product="bleomycin hydrolase" /protein_id="DAA10320.1" /db_xref="SGD:S000005183" /translation="MSSSIDISKINSWNKEFQSDLTHQLATTVLKNYNADDALLNKTR LQKQDNRVFNTVVSTDSTPVTNQKSSGRCWLFAATNQLRLNVLSELNLKEFELSQAYL FFYDKLEKANYFLDQIVSSADQDIDSRLVQYLLAAPTEDGGQYSMFLNLVKKYGLIPK DLYGDLPYSTTASRKWNSLLTTKLREFAETLRTALKERSADDSIIVTLREQMQREIFR LMSLFMDIPPVQPNEQFTWEYVDKDKKIHTIKSTPLEFASKYAKLDPSTPVSLINDPR HPYGKLIKIDRLGNVLGGDAVIYLNVDNETLSKLVVKRLQNNKAVFFGSHTPKFMDKK TGVMDIELWNYPAIGYNLPQQKASRIRYHESLMTHAMLITGCHVDETSKLPLRYRVEN SWGKDSGKDGLYVMTQKYFEEYCFQIVVDINELPKELASKFTSGKEEPIVLPIWDPMG ALAK" gene 202428..204872 /gene="KEX2" /locus_tag="YNL238W" /gene_synonym="QDS1" /gene_synonym="SRB1" /gene_synonym="VMA45" mRNA 202428..204872 /gene="KEX2" /locus_tag="YNL238W" /gene_synonym="QDS1" /gene_synonym="SRB1" /gene_synonym="VMA45" /product="kexin KEX2" CDS 202428..204872 /gene="KEX2" /locus_tag="YNL238W" /gene_synonym="QDS1" /gene_synonym="SRB1" /gene_synonym="VMA45" /EC_number="3.4.21.61" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004252 serine-type endopeptidase activity [PMID:2646633]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:8308064]" /experiment="EXISTENCE:mutant phenotype:GO:0007323 peptide pheromone maturation [PMID:6430565]" /note="Kexin, a subtilisin-like protease (proprotein convertase); a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway" /codon_start=1 /product="kexin KEX2" /protein_id="DAA10321.1" /db_xref="SGD:S000005182" /translation="MKVRKYITLCFWWAFSTSALVSSQQIPLKDHTSRQYFAVESNET LSRLEEMHPNWKYEHDVRGLPNHYVFSKELLKLGKRSSLEELQGDNNDHILSVHDLFP RNDLFKRLPVPAPPMDSSLLPVKEAEDKLSINDPLFERQWHLVNPSFPGSDINVLDLW YNNITGAGVVAAIVDDGLDYENEDLKDNFCAEGSWDFNDNTNLPKPRLSDDYHGTRCA GEIAAKKGNNFCGVGVGYNAKISGIRILSGDITTEDEAASLIYGLDVNDIYSCSWGPA DDGRHLQGPSDLVKKALVKGVTEGRDSKGAIYVFASGNGGTRGDNCNYDGYTNSIYSI TIGAIDHKDLHPPYSEGCSAVMAVTYSSGSGEYIHSSDINGRCSNSHGGTSAAAPLAA GVYTLLLEANPNLTWRDVQYLSILSAVGLEKNADGDWRDSAMGKKYSHRYGFGKIDAH KLIEMSKTWENVNAQTWFYLPTLYVSQSTNSTEETLESVITISEKSLQDANFKRIEHV TVTVDIDTEIRGTTTVDLISPAGIISNLGVVRPRDVSSEGFKDWTFMSVAHWGENGVG DWKIKVKTTENGHRIDFHSWRLKLFGESIDSSKTETFVFGNDKEEVEPAATESTVSQY SASSTSISISATSTSSISIGVETSAIPQTTTASTDPDSDPNTPKKLSSPRQAMHYFLT IFLIGATFLVLYFMFFMKSRRRIRRSRAETYEFDIIDTDSEYDSTLDNGTSGITEPEE VEDFDFDLSDEDHLASLSSSENGDAEHTIDSVLTNENPFSDPIKQKFPNDANAESASN KLQELQPDVPPSSGRS" gene 205188..206567 /gene="YTP1" /locus_tag="YNL237W" mRNA 205188..206567 /gene="YTP1" /locus_tag="YNL237W" /product="Ytp1p" CDS 205188..206567 /gene="YTP1" /locus_tag="YNL237W" /note="Probable type-III integral membrane hypothetical protein; has regions of similarity to mitochondrial electron transport proteins" /codon_start=1 /product="Ytp1p" /protein_id="DAA10322.1" /db_xref="SGD:S000005181" /translation="MTAANKNIVFGFSRSISAILLICFFFEKVCGDMEHDMGMDDTSG YTRPEIVQAGSKSFHWLCTLGFLLLLPSVVTCLSFAGRIYSATLLQCTCAVYAFLEAA VLRFQDNDGVENRTSRGTAWFLVGLTWITLFFGGLAGGTGFLVKSKRLQTFISNAGEK RLSYIHRGLSFLTVLTGWVKVCLAPVALFGFCREAHTGQCIAHGIMGSAFVLYGFIYV LVLVIPWIRSAQTSYSQDYVDSWVMCIWGVVNTFTEHRWGREGWSVHDYQHTFMGIIW WTGGILGIFLSRNGRRTFVPSLIIIFTGWAMSEHAQHLIISTKVHNMFGLVLMCGGAL RIIEISFLLRDKRTLDKIHSFQYLAPFCLVCSGLLFMGANEEQLILVLRLGGDHSAYV LIIVSGAFLVYFWMIACLEFYLYLLEKGKQGFLPKSYELEEENNNVSFELDNISNEDV DEDTTPFNV" gene 206930..209854 /gene="SIN4" /locus_tag="YNL236W" /gene_synonym="BEL2" /gene_synonym="GAL22" /gene_synonym="MED16" /gene_synonym="RYE1" /gene_synonym="SDI3" /gene_synonym="SSF5" /gene_synonym="SSN4" /gene_synonym="SSX3" /gene_synonym="TSF3" mRNA 206930..209854 /gene="SIN4" /locus_tag="YNL236W" /gene_synonym="BEL2" /gene_synonym="GAL22" /gene_synonym="MED16" /gene_synonym="RYE1" /gene_synonym="SDI3" /gene_synonym="SSF5" /gene_synonym="SSN4" /gene_synonym="SSX3" /gene_synonym="TSF3" /product="Sin4p" CDS 206930..209854 /gene="SIN4" /locus_tag="YNL236W" /gene_synonym="BEL2" /gene_synonym="GAL22" /gene_synonym="MED16" /gene_synonym="RYE1" /gene_synonym="SDI3" /gene_synonym="SSF5" /gene_synonym="SSN4" /gene_synonym="SSX3" /gene_synonym="TSF3" /experiment="EXISTENCE:direct assay:GO:0016592 mediator complex [PMID:9891034]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:20308326]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:genetic interaction:GO:0034605 cellular response to heat [PMID:23447536]" /experiment="EXISTENCE:genetic interaction:GO:0070202 regulation of establishment of protein localization to chromosome [PMID:23447536]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16452140]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:23447536]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12558798]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12482986]" /experiment="EXISTENCE:mutant phenotype:GO:0070202 regulation of establishment of protein localization to chromosome [PMID:23447536]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both positive and negative transcriptional regulation; dispensible for basal transcription" /codon_start=1 /product="Sin4p" /protein_id="DAA10323.1" /db_xref="SGD:S000005180" /translation="MMLGEHLMSWSKTGIIAYSDSQSSNANICLTFLESINGINWRFH TPQKYVLHPQLHEVQYQESSSTLSTHSTTTSVNGSTTAGVGSTPNFGGNSNKSPPQFF YNISSIHWNNWFSLPGDMLAVCDELGNMTMLITGQRPDRATTYEKLTMVFQDNVYKIY NHVMPLKPVDKLKPMNIERKQTRKEYNTSILEFRWLTSSKSVIVSQFCAFDSSSNTYR SRAQQVPPYGVYHPPFIKYACLAIRKNGQIDFWYQFSNSKDHKKITLQLLDTSNQRFK DLQWLEFARITPMNDDQCMLITTYSKLSKNISFYKLHVNWNLNATKPNVLNDPSLKIQ FILSTTLDPTDDEGHVLKLENLHVVSKSSIEKDPSPEILVLYNVCDTSKSLVKRYRLA PTQLSAEYLVILKPDLNIDRNNSTNQIFQSRRYNLRRHSDIVLDKKVTLITSEMFDAF VSFYFEDGTIESYNQNDWKLETERLISQSQLGKFKNIIASPLSAGFNYGKLPLPPSVE WMKVSPSMCGVIVKQYNKKWPQFYAAVQKNYADPEKDSINATALAFGYVKSLHKQISA EDLTIAAKTHILRISFLDRKRAKEFITTLLKSLYSFFNISPDAPKEIMDKIITSRPLQ KIMLLQLELGSCFSQENIEEMARVILYLKNVLFAFNGVARNFHFAIEQISNNSNQQQN PKLFQTIFSKQDLIHSLIPVAKWFVKFITYLTQEILILINDPTNKEYTLVHGIFGAKM SRTLILSILNEIKKVTQIVAKFPETSYPILNESSTFLKLVLSESPVDFEKFETFLVDV NNKFIALCEQQPSQEREFSLLVKAEIPPEYAKVGDFLLQYANNAVISHANAAAVYFAD TSGLKISNSEFFNPEIFHLLQPLEEGLIIDTDKLPIKNRTSKSFSKLLYDDVTCDKLS VSEISDGKLKRCSRCGSVTRAGNIISSDKTIVPTSIQTKRWPTMYTRLCICSGMLFEM DG" gene 210233..211513 /locus_tag="YNL234W" mRNA 210233..211513 /locus_tag="YNL234W" /product="hypothetical protein" CDS 210233..211513 /locus_tag="YNL234W" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0020037 heme binding [PMID:9988749]" /note="hypothetical protein with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10324.1" /db_xref="SGD:S000005178" /translation="MTGEKILHSQLLTNSDMSSGNVHHTKPMMYNVTLPSYNSSSIGP VDNLKINERPGSHDHSMRSEMSSKNSGSDFMPQSISRSEGSVYQVKIDRGDSPNTEGF DFKVNARDLLLLRMSWDILLREYLTPKELKVFQALLYSNKHITSTERPYLNTAPDGMI SKTIDPTARPRKTKQRDNDNKVDTALFCSQFYDNLIAMDPLLEEYFPSLKHQAVSFCK VLDSAIDNLENVHVLDDYIVKLGKRHSRILGIKTVGFEVMGKAFMTTLQDRFGSFLTL ELKNLWGQLYSYLANCMITAGKDPMEKIQPDFSYNGDSVVLNFSIPKLAMHDISTVNK LQMVKTKNATIPHNITQVPTNKIPTEILLDNSSTPIKSDRESTPPISPKGSGSTKPSI GSSTVVESNTKKNNYDEKIHLLQKTAQQKNCSIM" gene 211922..214600 /gene="BNI4" /locus_tag="YNL233W" mRNA 211922..214600 /gene="BNI4" /locus_tag="YNL233W" /product="Bni4p" CDS 211922..214600 /gene="BNI4" /locus_tag="YNL233W" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:15901837|PMID:15470103]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0005940 septin ring [PMID:15901837|PMID:9314530]" /experiment="EXISTENCE:direct assay:GO:0032174 cellular bud neck septin collar [PMID:15901837]" /experiment="EXISTENCE:mutant phenotype:GO:0000917 division septum assembly [PMID:15470103]" /experiment="EXISTENCE:mutant phenotype:GO:0006031 chitin biosynthetic process [PMID:15470103]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:9314530|PMID:12529424]" /note="Targeting subunit for Glc7p protein phosphatase; localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p; phosphorylation by Slt2p and Kss1p involved in regulating Bni4p in septum assembly" /codon_start=1 /product="Bni4p" /protein_id="DAA10325.1" /db_xref="SGD:S000005177" /translation="MSDSISDSKSSELLNSTFYSSTSINTLDHARTFRNSLILKEISD QSLNSSIKPCESVLDRDVESSVLQRSFGESNARDSEVQTVNMTTSPSLSALADILNER SKYADQKTRKAQNIESSIIEEEEEAEEQNNSINYHEDITGSRLSVREEANENLAMTSP NLIDIDGSNSIQVAPLSLPSFEEPDFLSTPRVKPDSQGPRSKVSTRRTILERDNNLPV KREENTIINSETESTTHSAPFLKEDPKPSPPSSKLYNPKVRLNKAEARKYTDSSAQRT TSAGSVLEDTSMHKKKKSIFSFLKKKEPKPVIGNNSVTNEKNKMSSSSTFSMNIQTSL KTPEKLKKKSHSSSSIFNSFLKGKIETSDSPRKEPMRQKKRTPKSKDKKQDTEQIIDA ASVLSTESPLLRKNHDDTPVKIDHVTRSIDQRKPTPLNMDLILGGDKQINTPLQEHVR EDDDAKNDLQLPTKDNFLSLDYEAPSPAFSKHDTGEVLFPKFLDNHEVDSIVSLERTR STKSNKRSSMNSQRRSLTDTLSIKAQSEGMFITEASSVVLSTPDLTKSPASSILKNGR FEYSDNFSREHSYEGTTNEDFLDIKDDSGPLKKDDIFLESIEQKFDQLVMASDEEKTE VERDVPKPREEPLKKDSERQSVFADDDNELISDIMEFASFINFGDDDLNLDLDLGDTT ASYATETPEPVGNDEVNRSGTFDTRNNKEDSYKERETQSYSAAGATTYGDERQGQLHT FEQDGSEINDNEFENEDFNKHIEQPIEVTPRNNAYLPEFEPNRPVSMSFKGLKAPRMN TSFIDSMTPDSPVKSDLTSLGEVYVNSNNDQGVRFSSQIILYDTYGEFEYDRHPEIST CNQLTPQLAQMIKLELNELKSAMEVHDDSRCYTHFY" gene 214923..215801 /gene="CSL4" /locus_tag="YNL232W" /gene_synonym="SKI4" mRNA 214923..215801 /gene="CSL4" /locus_tag="YNL232W" /gene_synonym="SKI4" /product="exosome non-catalytic core subunit CSL4" CDS 214923..215801 /gene="CSL4" /locus_tag="YNL232W" /gene_synonym="SKI4" /experiment="EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:10465791|PMID:19046973]" /experiment="EXISTENCE:direct assay:GO:0000177 cytoplasmic exosome (RNase complex) [PMID:19046973|PMID:10465791]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11027292]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11027292]" /experiment="EXISTENCE:direct assay:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:15935758|PMID:17643380|PMID:15828860]" /experiment="EXISTENCE:genetic interaction:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:11027292|PMID:19060898]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10508172|PMID:10465791]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:19060898|PMID:11027292]" /experiment="EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:27385342]" /experiment="EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:11910110]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:10465791]" /note="Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; human homolog EXOSC1 partially complements yeast csl4 null mutant, and can complement inviability of strain in which expression of CSL4 is repressed" /codon_start=1 /product="exosome non-catalytic core subunit CSL4" /protein_id="DAA10326.1" /db_xref="SGD:S000005176" /translation="MACNFQFPEIAYPGKLICPQYGTENKDGEDIIFNYVPGPGTKLI QYEHNGRTLEAITATLVGTVRCEEEKKTDQEEEREGTDQSTEEEKSVDASPNDVTRRT VKNILVSVLPGTEKGRKTNKYANNDFANNLPKEGDIVLTRVTRLSLQRANVEILAVED KPSPIDSGIGSNGSGIVAAGGGSGAATFSVSQASSDLGETFRGIIRSQDVRSTDRDRV KVIECFKPGDIVRAQVLSLGDGTNYYLTTARNDLGVVFARAANGAGGLMYATDWQMMT SPVTGATEKRKCAKPF" gene complement(215987..217042) /gene="PDR16" /locus_tag="YNL231C" /gene_synonym="SFH3" mRNA complement(215987..217042) /gene="PDR16" /locus_tag="YNL231C" /gene_synonym="SFH3" /product="phosphatidylinositol transporter" CDS complement(215987..217042) /gene="PDR16" /locus_tag="YNL231C" /gene_synonym="SFH3" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:12869188|PMID:24403601]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0008526 phosphatidylinositol transfer activity [PMID:10848624]" /experiment="EXISTENCE:direct assay:GO:0015914 phospholipid transport [PMID:10848624]" /experiment="EXISTENCE:direct assay:GO:0032934 sterol binding [PMID:36482167|PMID:31690622]" /experiment="EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:29187527]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:12869188]" /experiment="EXISTENCE:genetic interaction:GO:0008526 phosphatidylinositol transfer activity [PMID:9890948]" /experiment="EXISTENCE:genetic interaction:GO:0008654 phospholipid biosynthetic process [PMID:9890948]" /experiment="EXISTENCE:genetic interaction:GO:0009410 response to xenobiotic stimulus [PMID:9890948]" /experiment="EXISTENCE:genetic interaction:GO:0015914 phospholipid transport [PMID:9890948]" /experiment="EXISTENCE:genetic interaction:GO:0016126 sterol biosynthetic process [PMID:9890948]" /experiment="EXISTENCE:mutant phenotype:GO:0008526 phosphatidylinositol transfer activity [PMID:9890948]" /experiment="EXISTENCE:mutant phenotype:GO:0015914 phospholipid transport [PMID:9890948]" /experiment="EXISTENCE:mutant phenotype:GO:0043942 negative regulation of sexual sporulation resulting in formation of a cellular spore [PMID:24403601]" /note="Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="phosphatidylinositol transporter" /protein_id="DAA10327.1" /db_xref="SGD:S000005175" /translation="MFKRFSKKKEAPEDPKNLINIDKPIKELPASIAIPKEKPLTGEQ QKMYDEVLKHFSNPDLKVYTSEKNKSEDDLKPLEEEEKAWLTRECFLRYLRATKWVLK DCIDRITMTLAWRREFGISHLGEEHGDKITADLVAVENESGKQVILGYENDARPILYL KPGRQNTKTSHRQVQHLVFMLERVIDFMPAGQDSLALLIDFKDYPDVPKVPGNSKIPP IGVGKEVLHILQTHYPERLGKALLTNIPWLAWTFLKLIHPFIDPLTREKLVFDEPFVK YVPKNELDSLYGGDLKFKYNHDVYWPALVETAREKRDHYFKRFQSFGGIVGLSEVDLR GTHEKLLYPVKSESSTV" gene complement(217523..218662) /gene="ELA1" /locus_tag="YNL230C" mRNA complement(217523..218662) /gene="ELA1" /locus_tag="YNL230C" /product="elongin A" CDS complement(217523..218662) /gene="ELA1" /locus_tag="YNL230C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:17296727]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:17296727]" /experiment="EXISTENCE:mutant phenotype:GO:0031463 Cul3-RING ubiquitin ligase complex [PMID:17296727]" /experiment="EXISTENCE:physical interaction:GO:0070449 elongin complex [PMID:10753924|PMID:10430890]" /note="Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex" /codon_start=1 /product="elongin A" /protein_id="DAA10328.1" /db_xref="SGD:S000005174" /translation="MKSLQTLCEISLMRNHSNIQSVSNVPYHLLKRILQKVKIPQLLK LEKSNVLLIFDDDELWLEFLRQDFPTNVHEQFVSKRDIICKYYFDFVKENDIELYHSN QDLLKSCVRQSVVKDIRNNKYRIPYRMLYSKYQQEVEKKQEESAERLRLEMQKLQQER EKKQTIVVDHTVYFKKRNTKKTTRLHNEPHSQLYMKSLKDHESRLKHFKDGGFNIAKR HAQRVAFGGQAGGQSSSPKKGPLSIKPEPVKVNRQMDNVTAEKKDVTQPITPVKKRRS ESPSIFLNRKKPALFRPTPKTNAAGSRPHTTAITNDHRTTSHPYPHKDVVTSISSVTA NPVTKGHKKKKSGIFVRNAGSDGDSFPHVTATGPTTRPYIYEPRK" gene complement(219137..220201) /gene="URE2" /locus_tag="YNL229C" mRNA complement(219137..220201) /gene="URE2" /locus_tag="YNL229C" /product="glutathione peroxidase" CDS complement(219137..220201) /gene="URE2" /locus_tag="YNL229C" /EC_number="1.11.1.9" /experiment="EXISTENCE:direct assay:GO:0004602 glutathione peroxidase activity [PMID:15371425]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10748041]" /experiment="EXISTENCE:direct assay:GO:0051219 phosphoprotein binding [PMID:10604478]" /experiment="EXISTENCE:genetic interaction:GO:0006808 regulation of nitrogen utilization [PMID:8755910]" /experiment="EXISTENCE:mutant phenotype:GO:0006808 regulation of nitrogen utilization [PMID:8002570]" /experiment="EXISTENCE:mutant phenotype:GO:0010621 negative regulation of transcription by transcription factor localization [PMID:10799523|PMID:10748041]" /experiment="EXISTENCE:mutant phenotype:GO:0032447 protein urmylation [PMID:14551258]" /experiment="EXISTENCE:physical interaction:GO:0006808 regulation of nitrogen utilization [PMID:8755910]" /note="Nitrogen catabolite repression transcriptional regulator; inhibits GLN3 transcription in good nitrogen source; role in sequestering Gln3p and Gat1p to the cytoplasm; has glutathione peroxidase activity and can mutate to acquire GST activity; self-assembly under limited nitrogen conditions creates [URE3] prion and releases catabolite repression" /codon_start=1 /product="glutathione peroxidase" /protein_id="DAA10329.1" /db_xref="SGD:S000005173" /translation="MMNNNGNQVSNLSNALRQVNIGNRNSNTTTDQSNINFEFSTGVN NNNNNNSSSNNNNVQNNNSGRNGSQNNDNENNIKNTLEQHRQQQQAFSDMSHVEYSRI TKFFQEQPLEGYTLFSHRSAPNGFKVAIVLSELGFHYNTIFLDFNLGEHRAPEFVSVN PNARVPALIDHGMDNLSIWESGAILLHLVNKYYKETGNPLLWSDDLADQSQINAWLFF QTSGHAPMIGQALHFRYFHSQKIASAVERYTDEVRRVYGVVEMALAERREALVMELDT ENAAAYSAGTTPMSQSRFFDYPVWLVGDKLTIADLAFVPWNNVVDRIGINIKIEFPEV YKWTKHMMRRPAVIKALRGE" gene complement(220659..222431) /gene="JJJ1" /locus_tag="YNL227C" mRNA complement(220659..222431) /gene="JJJ1" /locus_tag="YNL227C" /product="Jjj1p" CDS complement(220659..222431) /gene="JJJ1" /locus_tag="YNL227C" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:17242366]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:20368619|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:17242366]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:20368619]" /experiment="EXISTENCE:mutant phenotype:GO:0005730 nucleolus [PMID:20368619]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:20368619]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:11378903]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:17242366]" /note="Co-chaperone that stimulates the ATPase activity of Ssa1p; required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis" /codon_start=1 /product="Jjj1p" /protein_id="DAA10330.1" /db_xref="SGD:S000005171" /translation="MKTCYYELLGVETHASDLELKKAYRKKALQYHPDKNPDNVEEAT QKFAVIRAAYEVLSDPQERAWYDSHKEQILNDTPPSTDDYYDYEVDATVTGVTTDELL LFFNSALYTKIDNSAAGIYQIAGKIFAKLAKDEILSGKRLGKFSEYQDDVFEQDINSI GYLKACDNFINKTDKLLYPLFGYSPTDYEYLKHFYKTWSAFNTLKSFSWKDEYMYSKN YDRRTKREVNRRNEKARQQARNEYNKTVKRFVVFIKKLDKRMKEGAKIAEEQRKLKEQ QRKNELNNRRKFGNDNNDEEKFHLQSWQTVKEENWDELEKVYDNFGEFENSKNDKEGE VLIYECFICNKTFKSEKQLKNHINTKLHKKNMEEIRKEMEEENITLGLDNLSDLEKFD SADESVKEKEDIDLQALQAELAEIERKLAESSSEDESEDDNLNIEMDIEVEDVSSDEN VHVNTKNKKKRKKKKKAKVDTETEESESFDDTKDKRSNELDDLLASLGDKGLQTDDDE DWSTKAKKKKGKQPKKNSKSTKSTPSLSTLPSSMSPTSAIEVCTTCGESFDSRNKLFN HVKIAGHAAVKNVVKRKKVKTKRI" gene complement(222724..224469) /gene="CNM67" /locus_tag="YNL225C" mRNA complement(222724..224469) /gene="CNM67" /locus_tag="YNL225C" /product="Cnm67p" CDS complement(222724..224469) /gene="CNM67" /locus_tag="YNL225C" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005824 outer plaque of spindle pole body [PMID:11514632]" /experiment="EXISTENCE:direct assay:GO:0061499 outer plaque of mitotic spindle pole body [PMID:9585415]" /experiment="EXISTENCE:mutant phenotype:GO:0005200 structural constituent of cytoskeleton [PMID:11514632]" /experiment="EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:9571234|PMID:10749924]" /experiment="EXISTENCE:mutant phenotype:GO:0051300 spindle pole body organization [PMID:9571234]" /note="Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication" /codon_start=1 /product="Cnm67p" /protein_id="DAA10331.1" /db_xref="SGD:S000005169" /translation="MTDFDLMNFPFHERLDSPVSENGEIKDGEPIPQNWLNENHVGKS ILPLFVNPEDVINCNFSNARDSYEENKSPSMDQMNYARNTSYQESPGLQERPKNEKDK SPIGTDVHKKDVPNFIHSTPRENSSKHFTRANEQASAQPTDEHTSPDISIEDCNGAKI FLQNSLSKEDFRMLENVILGYQKKVIELGRDNLRQEERANSLQKELEAATKSNDKTLD NKKKIEEQTVLIENLTKDLSLNKEMLEKANDTIQTKHTALLSLTDSLRKAELFEIPIG ILFFDLYDSEENSSKLDHILQEKYPNIKGFLCASQQEELSRISQRFKNAKAEAEDLRN ELENKKIEIQTMREKNNTLIGTNKTLSKQNKILCDKFDKLTIDEKEILKGCNEEIKIK LERLNERLGSWEKSKEKYETSLKDKEKMLADAEKKTNTLSKELDNLRSRFGNLEGNTS ERITIKNILQSRPDISAEECNFLMVEQIDSANLTTLQNTVKEIVLAVGIPYPKLRRKI PLLAIKLKYENIMLSNFAQRLHRQVYSQEMNLKKFTDQAYYDFMSTRRMDSIDHHLER CLDHLYDHILEKMVK" gene complement(224796..227099) /gene="SQS1" /locus_tag="YNL224C" /gene_synonym="PFA1" mRNA complement(224796..227099) /gene="SQS1" /locus_tag="YNL224C" /gene_synonym="PFA1" /product="Sqs1p" CDS complement(224796..227099) /gene="SQS1" /locus_tag="YNL224C" /gene_synonym="PFA1" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:19927118]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:19927118]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:19927118]" /experiment="EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:19927118|PMID:16227579]" /experiment="EXISTENCE:genetic interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:16945917]" /experiment="EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:19927118]" /experiment="EXISTENCE:genetic interaction:GO:0030490 maturation of SSU-rRNA [PMID:19927118|PMID:19801658]" /experiment="EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:19927118]" /note="Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress" /codon_start=1 /product="Sqs1p" /protein_id="DAA10332.1" /db_xref="SGD:S000005168" /translation="MAKRHSHYQGSRRRHARGSNSKKAGRGNAKGIQGRKIKKKPTPT NSWHNSSIPLGEGDLDDVGADFNPGRAFISPKTIEDYYFGRDAKSRSMKMGGLRPGNR YDSSTDLQAGRAAFRKRPMQFVKAKEVYDPSHNMIQKLRAKNETKNSEEIVEREADVF EEPGKMTSDVEYINNEDSENEDDDSQNSPSTDHSLSSNESKVEDGDLFFVDEEAQQSP DLTKIKRVCIEEIARPREVAIEFDPILTIGKVELSVSEGNESKEISVDVPNKGNKTYH PFAGYISNVLHGMHTSDSDNDELDYEIETENNSEPLYESSASSEVDQGFNYVGQRHNS RADNNLLPSPSPQLTEDIKCLSINGTKTFEGNNDNLPSPASEELEFGFKEEDFVINTN DIVVSNIRMGGVDNSYYLRCYRLLGDYDFHWIDQDLLTDFVVDELGLPEDRLPAYLNF IKNSLIPKIEPAEPTYSDIPISDSSDEGDSYEGDSYEDDEDMASSVVHSDIEEGLDDL IAYTLKHDTERFKTFETKSLETKGKGKKKKLLIDDALALDTETLETLQSKFSKRIETK AKKRKAKEDFIDQENRNSNDMLKKYPYGLHIQNIKDEFESFLSRNNDRLTFPPLDPHG NKTVMKIAKHYNMKSSKIGKANHTSVVVEKIKKTKWSSPNYSLIDQLMRQRPVFMRID IRRPREEQAAFERTKTIRGKFHVKEGEIVGQNAPEIGNENIGRRMLEKLGWKSGEGLG IQGNKGISEPIFAKIKKNRSGLRHSES" gene 227370..228854 /gene="ATG4" /locus_tag="YNL223W" /gene_synonym="APG4" /gene_synonym="AUT2" mRNA 227370..228854 /gene="ATG4" /locus_tag="YNL223W" /gene_synonym="APG4" /gene_synonym="AUT2" /product="cysteine protease ATG4" CDS 227370..228854 /gene="ATG4" /locus_tag="YNL223W" /gene_synonym="APG4" /gene_synonym="AUT2" /experiment="EXISTENCE:direct assay:GO:0004197 cysteine-type endopeptidase activity [PMID:11038174]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22240591]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22240591]" /experiment="EXISTENCE:direct assay:GO:0019786 protein-phosphatidylethanolamide deconjugating activity [PMID:11038174]" /experiment="EXISTENCE:direct assay:GO:0051697 protein delipidation [PMID:17632063]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0004197 cysteine-type endopeptidase activity [PMID:11038174]" /experiment="EXISTENCE:mutant phenotype:GO:0006501 C-terminal protein lipidation [PMID:11038174]" /experiment="EXISTENCE:mutant phenotype:GO:0019786 protein-phosphatidylethanolamide deconjugating activity [PMID:11038174]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:11149920]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /note="Conserved cysteine protease required for autophagy; functions in both early and late stages of autophagosome formation; primes Atg8p by removing the C-terminal arginine residue of nascent Atg8p in preparation for conjugation with phosphatidylethanolamide (PE), and also cleaves the PE modified, membrane-bound form to reverse conjugation; regulates the membrane-binding state of Atg8p, that is required for autophagosome formation and autophagy, as well as the cytoplasm-to-vacuole targeting pathway" /codon_start=1 /product="cysteine protease ATG4" /protein_id="DAA10333.1" /db_xref="SGD:S000005167" /translation="MQRWLQLWKMDLVQKVSHGVFEGSSEEPAALMNHDYIVLGEVYP ERDEESGAEQCEQDCRYRGEAVSDGFLSSLFGREISSYTKEFLLDVQSRVNFTYRTRF VPIARAPDGPSPLSLNLLVRTNPISTIEDYIANPDCFNTDIGWGCMIRTGQSLLGNAL QILHLGRDFRVNGNESLERESKFVNWFNDTPEAPFSLHNFVSAGTELSDKRPGEWFGP AATARSIQSLIYGFPECGIDDCIVSVSSGDIYENEVEKVFAENPNSRILFLLGVKLGI NAVNESYRESICGILSSTQSVGIAGGRPSSSLYFFGYQGNEFLHFDPHIPQPAVEDSF VESCHTSKFGKLQLSEMDPSMLIGILIKGEKDWQQWKLEVAESAIINVLAKRMDDFDV SCSMDDVESVSSNSMKKDASNNENLGVLEGDYVDIGAIFPHTTNTEDVDEYDCFQDIH CKKQKIVVMGNTHTVNANLTDYEVEGVLVEKETVGIHSPIDEKC" gene 229094..229714 /gene="SSU72" /locus_tag="YNL222W" mRNA 229094..229714 /gene="SSU72" /locus_tag="YNL222W" /product="RNA polymerase II subunit A C-terminal domain phosphatase" CDS 229094..229714 /gene="SSU72" /locus_tag="YNL222W" /EC_number="3.1.3.16" /experiment="EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:22235117]" /experiment="EXISTENCE:direct assay:GO:0004725 protein tyrosine phosphatase activity [PMID:12660165]" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]" /experiment="EXISTENCE:direct assay:GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity [PMID:22235117|PMID:15125841]" /experiment="EXISTENCE:genetic interaction:GO:0001174 transcriptional start site selection at RNA polymerase II promoter [PMID:8657130]" /experiment="EXISTENCE:genetic interaction:GO:0004721 phosphoprotein phosphatase activity [PMID:12660165]" /experiment="EXISTENCE:genetic interaction:GO:0005634 nucleus [PMID:11046131]" /experiment="EXISTENCE:genetic interaction:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:11046131]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:17101794]" /experiment="EXISTENCE:mutant phenotype:GO:0001174 transcriptional start site selection at RNA polymerase II promoter [PMID:8657130]" /experiment="EXISTENCE:mutant phenotype:GO:0004722 protein serine/threonine phosphatase activity [PMID:22235117]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:17101794]" /experiment="EXISTENCE:mutant phenotype:GO:0006369 termination of RNA polymerase II transcription [PMID:12660165|PMID:22235117]" /experiment="EXISTENCE:mutant phenotype:GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity [PMID:22235117|PMID:15125841]" /experiment="EXISTENCE:mutant phenotype:GO:0009302 sno(s)RNA transcription [PMID:12660165]" /experiment="EXISTENCE:mutant phenotype:GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled [PMID:12944462|PMID:12819204]" /experiment="EXISTENCE:mutant phenotype:GO:0030847 termination of RNA polymerase II transcription, exosome-dependent [PMID:12819204|PMID:12944462]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:12704082]" /experiment="EXISTENCE:mutant phenotype:GO:0031564 transcription antitermination [PMID:12453421]" /experiment="EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:11046131]" /experiment="EXISTENCE:physical interaction:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12453421]" /experiment="EXISTENCE:physical interaction:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:11046131]" /note="Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo" /codon_start=1 /product="RNA polymerase II subunit A C-terminal domain phosphatase" /protein_id="DAA10334.1" /db_xref="SGD:S000005166" /translation="MPSHRNSNLKFCTVCASNNNRSMESHKVLQEAGYNVSSYGTGSA VRLPGLSIDKPNVYSFGTPYNDIYNDLLSQSADRYKSNGLLQMLDRNRRLKKAPEKWQ ESTKVFDFVFTCEERCFDAVCEDLMNRGGKLNKIVHVINVDIKDDDENAKIGSKAILE LADMLNDKIEQCEKDDIPFEDCIMDILTEWQSSHSQLPSLYAPSYY" gene complement(230105..230672) /gene="SNR19" /locus_tag="YNCN0005C" ncRNA complement(230105..230672) /ncRNA_class="snRNA" /gene="SNR19" /locus_tag="YNCN0005C" /product="SNR19" /experiment="EXISTENCE:direct assay:GO:0000243 commitment complex [PMID:2529976]" /experiment="EXISTENCE:direct assay:GO:0000395 mRNA 5'-splice site recognition [PMID:18084028]" /experiment="EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:2440584]" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:2440584]" /experiment="EXISTENCE:direct assay:GO:0030627 pre-mRNA 5'-splice site binding [PMID:18084028|PMID:12214237]" /experiment="EXISTENCE:mutant phenotype:GO:0030627 pre-mRNA 5'-splice site binding [PMID:15989965|PMID:3056718]" /note="U1 spliceosomal RNA (U1 snRNA); snRNA U1 homolog" /db_xref="SGD:S000007295" gene complement(231068..233695) /gene="POP1" /locus_tag="YNL221C" mRNA complement(231068..233695) /gene="POP1" /locus_tag="YNL221C" /product="ribonuclease P/MRP protein subunit POP1" CDS complement(231068..233695) /gene="POP1" /locus_tag="YNL221C" /EC_number="3.1.26.5" /experiment="EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent [PMID:14729943]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:26135751|PMID:23700311]" /experiment="EXISTENCE:direct assay:GO:0005655 nucleolar ribonuclease P complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0005697 telomerase holoenzyme complex [PMID:27156450]" /experiment="EXISTENCE:direct assay:GO:0034965 intronic box C/D snoRNA processing [PMID:18713869]" /experiment="EXISTENCE:mutant phenotype:GO:0000171 ribonuclease MRP activity [PMID:16618965]" /experiment="EXISTENCE:mutant phenotype:GO:0004526 ribonuclease P activity [PMID:16618965]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:7926742]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:7926742]" /experiment="EXISTENCE:physical interaction:GO:0000172 ribonuclease MRP complex [PMID:17881380]" /note="Subunit of RNase MRP, nuclear RNase P and telomerase complexes; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA; binds to the RPR1 RNA subunit in RNase P" /codon_start=1 /product="ribonuclease P/MRP protein subunit POP1" /protein_id="DAA10335.1" /db_xref="SGD:S000005165" /translation="MSGSLSRGNGGKKVLNKNQLLKRNRIRNARSIRAEAVAASSTKT GTPSDLSESGSKLNVDQFISSRQFEVKQLQLAMHNSKAASSTRIFQALPRKLRRRTAS HNVRRIPKRMRNRALREMRKSDQQDVLKGSSASSRKAHGLNAKQLYKARMSIKLLRLA SKSTSMKLSMPPEVTSSNCHVRQKIKTLKRMIKESSTANPNIKLLNNRMGSYDCTGVN ELAPIPKGRVKYTKRQKHFAWLPTHIWNAKRSHMMKRWGYQMVWAPTQKCFKLTHRLG GDTCSSDGALCMDSSYIGTIIVKDKSNDSEGDFLKSIIGKLTAERANLRKYREGQVLF QGLIYSFNEENGEDSTKPLGPCDVFWVQKDTAIIRLHPSIYTQVFNILLQHKEKLTVQ DCRYSLASVTLKGAKALESLASCLRSTEYSKSFEQFKMVSMITDHNALPQRCTFAFEA IDPRHLAAPKKLNDSQRKTVNSDDILSLHENYPQDEINAVFNELCDPESRTQSYNNQN TLKEISARRYKLLTATPNSINKTTVPFKESDDPSIPLVIIRRLKTRDWIVVLPWFWLL PLWHLLNRIPRMYHIGLRQFQQIQYENKQLYFPDDYPFTQLGYIENSFYKKEASKTKW DRKPMGKRINFEKIKDIHNTKLPAYSGEIGDFFSSDWRFLQILRNGIDYLQRNDKTLE LMDSKKTGQFNAQGVRDINCVNDVLEFCKDYEAKTKAMSLSIEENIPVALCKNRKCQF RTPDSISVNSSSFSLTFFPRCIIAVSCTLLERGHPKDNARIYQVPEKDLEHWLQLAKG VYRPNGRKDHDLKIPLPEVHDLIGFITSGTYHLNCGNGMGIGFIDHHAAIRQPTRYVL IRNVGTNTYRLGEWSKISV" gene 234413..235714 /gene="ADE12" /locus_tag="YNL220W" /gene_synonym="BRA9" mRNA 234413..235714 /gene="ADE12" /locus_tag="YNL220W" /gene_synonym="BRA9" /product="adenylosuccinate synthase" CDS 234413..235714 /gene="ADE12" /locus_tag="YNL220W" /gene_synonym="BRA9" /EC_number="6.3.4.4" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:8706758]" /experiment="EXISTENCE:direct assay:GO:0004019 adenylosuccinate synthase activity [PMID:8706758|PMID:10417315]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004019 adenylosuccinate synthase activity [PMID:5807803]" /experiment="EXISTENCE:mutant phenotype:GO:0006164 purine nucleotide biosynthetic process [PMID:5807803]" /note="Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence" /codon_start=1 /product="adenylosuccinate synthase" /protein_id="DAA10336.1" /db_xref="SGD:S000005164" /translation="MVNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVV DGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKELETLEAKGLKNARSRLFVSSR AHLVFDFHQVTDKLRELELSGRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDQ PGAWEEFVARYKRLLETRRQRYGDFEYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAI EAKKKILVEGANALMLDIDFGTYPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYT TRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLVVLKYSTLINGYTSLN ITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITK YEDLPENAKKYLKYIEDFVGVPVEWVGTGPARESMLHKEIK" gene complement(235996..237663) /gene="ALG9" /locus_tag="YNL219C" mRNA complement(235996..237663) /gene="ALG9" /locus_tag="YNL219C" /product="dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase" CDS complement(235996..237663) /gene="ALG9" /locus_tag="YNL219C" /EC_number="2.4.1.259" /EC_number="2.4.1.261" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006487 protein N-linked glycosylation [PMID:15987956]" /experiment="EXISTENCE:direct assay:GO:0052918 dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [PMID:15987956]" /experiment="EXISTENCE:direct assay:GO:0052926 dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [PMID:15987956]" /experiment="EXISTENCE:mutant phenotype:GO:0000030 mannosyltransferase activity [PMID:8692962]" /experiment="EXISTENCE:mutant phenotype:GO:0005783 endoplasmic reticulum [PMID:8692962]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:8692962]" /experiment="EXISTENCE:mutant phenotype:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:15987956]" /note="Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of both the seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; human homolog ALG9 can complement yeast null mutant; mutation of human homolog causes type 1 congenital disorders of glycosylation" /codon_start=1 /product="dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase" /protein_id="DAA10337.1" /db_xref="SGD:S000005163" /translation="MNCKAVTISLLLLLFLTRVYIQPTFSLISDCDETFNYWEPLNLL VRGFGKQTWEYSPEYSIRSWAFLLPFYCILYPVNKFTDLESHWNFFITRACLGFFSFI MEFKLHREIAGSLALQIANIWIIFQLFNPGWFHASVELLPSAVAMLLYVGATRHSLRY LSTGSTSNFTKSLAYNFLASILGWPFVLILSLPLCLHYLFNHRIISTIRTAFDCCLIF SLTAFAVIVTDSIFYGKLAPVSWNILFYNVINASEESGPNIFGVEPWYYYPLNLLLNF PLPVLVLAILGIFHLRLWPLWASLFTWIAVFTQQPHKEERFLYPIYGLITLSASIAFY KVLNLFNRKPILKKGIKLSVLLIVAGQAMSRIVALVNNYTAPIAVYEQFSSLNQGGVK APVVNVCTGREWYHFPSSFLLPDNHRLKFVKSGFDGLLPGDFPESGSIFKKIRTLPKG MNNKNIYDTGKEWPITRCDYFIDIVAPINLTKDVFNPLHLMDNWNKLACAAFIDGENS KILGRAFYVPEPINRIMQIVLPKQWNQVYGVRYIDYCLFEKPTETTN" gene 238238..240001 /gene="MGS1" /locus_tag="YNL218W" mRNA 238238..240001 /gene="MGS1" /locus_tag="YNL218W" /product="ssDNA-dependent ATPase MGS1" CDS 238238..240001 /gene="MGS1" /locus_tag="YNL218W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:16251400]" /experiment="EXISTENCE:direct assay:GO:0017116 single-stranded DNA helicase activity [PMID:11459965|PMID:16251400]" /experiment="EXISTENCE:direct assay:GO:0033567 DNA replication, Okazaki fragment processing [PMID:16251400]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:32748509]" /experiment="EXISTENCE:genetic interaction:GO:0006282 regulation of DNA repair [PMID:16809783]" /experiment="EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:32748509]" /note="Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress" /codon_start=1 /product="ssDNA-dependent ATPase MGS1" /protein_id="DAA10338.1" /db_xref="SGD:S000005162" /translation="MSNKRTSVEQLISCPICSRKVFFSLINSHLDICGKEKSKPSSRP QTVSSLLAGPKKRKQANSEKFIDLENKDHEIKPGLKSESDDIEIVENESKRFKAAPST DFAKSIVEPASSRDQLHNDYESRWLQKISHLPLSEKLRPKELRDYVGQQHILSQDNGT LFKYIKQGTIPSMILWGPPGVGKTSLARLLTKTATTSSNESNVGSRYFMIETSATKAN TQELRGIFEKSKKEYQLTKRRTVLFIDEIHRFNKVQQDLLLPHVENGDIILIGATTEN PSFQLNNALISRCLIFVLEKLNVNELCIVLSRGIALLNKCRKQVWNIENPLKLSRSIL EYVVDLSVGDTRRALNMLEMIEVSTRERKADEEELSIDDVRDIIKNNSSNGLNTYYDP KGDNHYDTISAFHKSIRGGDENASLYYLARMLQGGEDPLYVARRMIRIASEDIGLRDS SLLPLAVAAHDAVMKVGLPEADLALAQCCVALARAPKSVELYRAWKKLRAMMSENMYS LASSEIPMHIRNAPTKLMEELGYHKGYKYNPDYIEGKVQQDYFPKEVLEKCPNKTDLK FLDGKHLGDKEDPDLRQSYQG" gene 240331..241311 /gene="PPN2" /locus_tag="YNL217W" mRNA 240331..241311 /gene="PPN2" /locus_tag="YNL217W" /product="putative serine/threonine-protein phosphatase" CDS 240331..241311 /gene="PPN2" /locus_tag="YNL217W" /EC_number="3.6.1.10" /experiment="EXISTENCE:direct assay:GO:0000298 endopolyphosphatase activity [PMID:31175919|PMID:28302909]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:23708375]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005775 vacuolar lumen [PMID:28302909]" /experiment="EXISTENCE:direct assay:GO:0006798 polyphosphate catabolic process [PMID:28302909]" /experiment="EXISTENCE:genetic interaction:GO:0000298 endopolyphosphatase activity [PMID:28302909]" /experiment="EXISTENCE:genetic interaction:GO:0006798 polyphosphate catabolic process [PMID:28302909]" /experiment="EXISTENCE:genetic interaction:GO:0016036 cellular response to phosphate starvation [PMID:28302909]" /experiment="EXISTENCE:genetic interaction:GO:0071469 cellular response to alkaline pH [PMID:39590716]" /experiment="EXISTENCE:mutant phenotype:GO:0000298 endopolyphosphatase activity [PMID:28302909]" /experiment="EXISTENCE:mutant phenotype:GO:0006798 polyphosphate catabolic process [PMID:39590716|PMID:28302909]" /experiment="EXISTENCE:mutant phenotype:GO:0071469 cellular response to alkaline pH [PMID:39590716]" /note="Zn2+-dependent endopolyphosphatase; required with PPN1 to mobilize polyphosphate stores in response to phosphate starvation; member of the PPP-superfamily of metalloproteases; directly involved in adaptation to mild alkaline conditions through polyphosphate hydrolysis; localizes to the vacuolar lumen via the MVB pathway; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate" /codon_start=1 /product="putative serine/threonine-protein phosphatase" /protein_id="DAA10339.1" /db_xref="SGD:S000005161" /translation="MEDKRKRRAATLSTALILFVACCVYTLYIFKFDNPRLSPPVSLL PTISTLKKIEHVTDLNKEYVFVGDVHGNYDEFIELIDDKIGGLGENITMILLGDFIHK GPDSDKVVSYILNHKDQVKCVLGNHEILVMMAYLNPDFSKWVRRPKLMTPLTFSTETN FIPQDISKISNAHGRLARELGFSKLSQLAEHCSMAIELDLDITGDILFGAHAGMVPGD FMKPNQIPGVSSLSNMKYVDKKNWSKTSREKENKNYVRWYTLWDKYGDHFSNAKVFYG HDASMGLNLRRQTKGLDTACIKNNLLSSMKVKYDIKKGQYDYELIQVQCS" gene 241689..244172 /gene="RAP1" /locus_tag="YNL216W" /gene_synonym="GRC4" /gene_synonym="GRF1" /gene_synonym="TBA1" /gene_synonym="TUF1" mRNA 241689..244172 /gene="RAP1" /locus_tag="YNL216W" /gene_synonym="GRC4" /gene_synonym="GRF1" /gene_synonym="TBA1" /gene_synonym="TUF1" /product="DNA-binding transcription factor RAP1" CDS 241689..244172 /gene="RAP1" /locus_tag="YNL216W" /gene_synonym="GRC4" /gene_synonym="GRF1" /gene_synonym="TBA1" /gene_synonym="TUF1" /experiment="EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:11455386]" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:16956377|PMID:9710643|PMID:26399229]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:1904543]" /experiment="EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:10487921|PMID:12051841]" /experiment="EXISTENCE:direct assay:GO:0001094 TFIID-class transcription factor complex binding [PMID:17074814]" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:18195009|PMID:20559389]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:2656680]" /experiment="EXISTENCE:direct assay:GO:0010833 telomere maintenance via telomere lengthening [PMID:9020083]" /experiment="EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:18195009]" /experiment="EXISTENCE:direct assay:GO:0031492 nucleosomal DNA binding [PMID:19782036]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:8510148|PMID:2225074|PMID:17656141]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:31742863]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:8194531]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:20559389]" /experiment="EXISTENCE:direct assay:GO:0061849 telomeric G-quadruplex DNA binding [PMID:8052638]" /experiment="EXISTENCE:direct assay:GO:0070187 shelterin complex [PMID:23746845]" /experiment="EXISTENCE:direct assay:GO:0071919 G-quadruplex DNA formation [PMID:8052638]" /experiment="EXISTENCE:genetic interaction:GO:0006110 regulation of glycolytic process [PMID:15300680]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:7958893]" /experiment="EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:7958893]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15300680]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:2010087]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:2237406]" /experiment="EXISTENCE:mutant phenotype:GO:0000781 chromosome, telomeric region [PMID:27122604]" /experiment="EXISTENCE:mutant phenotype:GO:0010833 telomere maintenance via telomere lengthening [PMID:9020083]" /experiment="EXISTENCE:mutant phenotype:GO:0031848 protection from non-homologous end joining at telomere [PMID:16096640]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:2010087]" /experiment="EXISTENCE:physical interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:12080091]" /experiment="EXISTENCE:physical interaction:GO:0070200 establishment of protein localization to telomere [PMID:11689698]" /experiment="EXISTENCE:physical interaction:GO:0071169 establishment of protein localization to chromatin [PMID:11689698]" /note="Essential DNA-binding transcription regulator that binds many loci; involved in transcription activation, repression, chromatin silencing, telomere length maintenance; represses divergent noncoding transcription at highly expressed genes, prevents transcription initiation at cryptic promoters near its binding sites; relocalizes to cytosol under hypoxia; recruits Sir complex to telomeric DNA; present in quiescent cell telomere hyperclusters" /codon_start=1 /product="DNA-binding transcription factor RAP1" /protein_id="DAA10340.1" /db_xref="SGD:S000005160" /translation="MSSPDDFETAPAEYVDALDPSMVVVDSGSAAVTAPSDSAAEVKA NQNEENTGATAAETSEKVDQTEVEKKDDDDTTEVGVTTTTPSIADTAATANIASTSGA SVTEPTTDDTAADEKKEQVSGPPLSNMKFYLNRDADAHDSLNDIDQLARLIRANGGEV LDSKPRESKENVFIVSPYNHTNLPTVTPTYIKACCQSNSLLNMENYLVPYDNFREVVD SRLQEESHSNGVDNSNSNSDNKDSIRPKTEIISTNTNGATEDSTSEKVMVDAEQQARL QEQAQLLRQHVSSTASITSGGHNDLVQIEQPQKDTSNNNNSNVNDEDNDLLTQDNNPQ TADEGNASFQAQRSMISRGALPSHNKASFTDEEDEFILDVVRKNPTRRTTHTLYDEIS HYVPNHTGNSIRHRFRVYLSKRLEYVYEVDKFGKLVRDDDGNLIKTKVLPPSIKRKFS ADEDYTLAIAVKKQFYRDLFQIDPDTGRSLITDEDTPTAIARRNMTMDPNHVPGSEPN FAAYRTQSRRGPIAREFFKHFAEEHAAHTENAWRDRFRKFLLAYGIDDYISYYEAEKA QNREPEPMKNLTNRPKRPGVPTPGNYNSAAKRARNYSSQRNVQPTANAASANAAAAAA AAASNSYAIPENELLDEDTMNFISSLKNDLSNISNSLPFEYPHEIAEAIRSDFSNEDI YDNIDPDTISFPPKIATTDLFLPLFFHFGSTRQFMDKLHEVISGDYEPSQAEKLVQDL CDETGIRKNFSTSILTCLSGDLMVFPRYFLNMFKDNVNPPPNVPGIWTHDDDESLKSN DQEQIRKLVKKHGTGRMEMRKRFFEKDLL" gene 244468..245430 /gene="IES2" /locus_tag="YNL215W" mRNA 244468..245430 /gene="IES2" /locus_tag="YNL215W" /product="Ies2p" CDS 244468..245430 /gene="IES2" /locus_tag="YNL215W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]" /note="Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="Ies2p" /protein_id="DAA10341.1" /db_xref="SGD:S000005159" /translation="MDSEASDIEAELSDSVSAGGEEYIDDDDYTEDIDDQIVTAKSSR RTARRSVPKGVRTSKRIRDKELSVEVDEDYDEEEDVLSPSKKRHLHTRSMDKRQVAAT ASEKSDIGDSKGNDGEIEDGILEEEESLEKELNRGGGKEVEKSEESYYAQNDVGQKGE EEQDGESGGYEDNEPSISKESDELVSVVNGNGNEEDDEVEATKENTTDSTRSTTTRSK MLLDLLEDGGSKKKLTDEEIQLRRAENARKRKNLSEKRLEEEKQDTINKLLKKRAGKS RSHLPNDDEKNDGSSSFVKPRRPYNSEGMTRILRRYEEDLFCTF" gene 245617..246216 /gene="PEX17" /locus_tag="YNL214W" /gene_synonym="PAS9" mRNA 245617..246216 /gene="PEX17" /locus_tag="YNL214W" /gene_synonym="PAS9" /product="Pex17p" CDS 245617..246216 /gene="PEX17" /locus_tag="YNL214W" /gene_synonym="PAS9" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:9425153]" /experiment="EXISTENCE:direct assay:GO:1902495 transmembrane transporter complex [PMID:20154681]" /experiment="EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:20154681|PMID:12667447|PMID:22375831]" /experiment="EXISTENCE:mutant phenotype:GO:0005778 peroxisomal membrane [PMID:9425153]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:9425153|PMID:16679311|PMID:12667447]" /experiment="EXISTENCE:physical interaction:GO:0016560 protein import into peroxisome matrix, docking [PMID:16679311]" /note="Membrane peroxin of the peroxisomal importomer complex; complex facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis" /codon_start=1 /product="Pex17p" /protein_id="DAA10342.1" /db_xref="SGD:S000005158" /translation="MTSINSFPRNIDWPSNIGIKKIEGTNPTVNAIKGLLYNGGSIYA FLYFVIAMFVEPTLQKQYQQRNDFSLFVLLRLRRIIAQLQKRLVMTPVSSLGFNEQNN FVERSTQTSDDNIIREDNSHWAEMIYQLQNMKQELQYFNRSSGQPSESIDDFVFQIKM VTDQVELTDRSRAFSNKSRNIIQGIREIKGWFVNGQVPR" gene complement(246460..247104) /gene="RRG9" /locus_tag="YNL213C" mRNA complement(246460..247104) /gene="RRG9" /locus_tag="YNL213C" /product="mitochondrial ribosome assembly protein RRG9" CDS complement(246460..247104) /gene="RRG9" /locus_tag="YNL213C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:19751518]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:10029995]" /note="hypothetical protein; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /codon_start=1 /product="mitochondrial ribosome assembly protein RRG9" /protein_id="DAA10343.1" /db_xref="SGD:S000005157" /translation="MNILRIACRSFHCLRCGPLLNENRGWSSKKIIKLVNKSSLSNKE FTEKVRDGTKDIPEWKKQKMAVRKKLQGQRWNPPKKISQEQMEALRLLKFNFPELTAS DLADRFKISPEAVRRILKSNWKRTDEENNNTYERWKRRGERIKEMYQRKEDADFVSNQ IVTSRKIILGSNSNSPELIARNVRTFKPFKPNNSTPEKKNTNKLYILKHLGSKQ" gene 247461..249809 /gene="VID27" /locus_tag="YNL212W" mRNA 247461..249809 /gene="VID27" /locus_tag="YNL212W" /product="Vid27p" CDS 247461..249809 /gene="VID27" /locus_tag="YNL212W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Cytoplasmic hypothetical protein; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth; contains two PH-like domains" /codon_start=1 /product="Vid27p" /protein_id="DAA10344.1" /db_xref="SGD:S000005156" /translation="MNILKKFMESGNKPELITIPSGQFNLLRSKNSPKAALECIYNNA TLSVRKIGKFDYELAVYRVEDDSEGGTGDEAENFEDDTISVLSTQSKKKEEEWSVEIS DKIMFHKTWDKQGNVALVWENLRGDEQDEKVQFVVAADVSFSDVEQFIQTVYRCQFEV RNKKSSLTASADDLKEIEHRSTRLFVQDDDDELDSSSDDFQDAKDTSFEHEKESEILE RTPSPLKKVPEGEYCCLVMSSLYMYDPIQEKFILQEPVVKVAIIDTGKYEFWLAIEGK DNRLGTQVAPNINPTFELATDAFLFNYTLQNITLSYMLKFKDLDKCIQFRFAWVKCLW MTLNKETWTDVPEKEKDYILDSSSVPLEKQFDDILHIDDRSNEERDKESSESENDSED EDDENDHSKRIISSEAFEEPRRATSKGNSSLTVAFRNNRSYVTRDNRIGVFKTDDEDD SLEFVAAIKNISNLGGKSIDPHKPMLYMEDRNLILTDGENENKLYKMDIERGKVIEEW STGDKNVVQYGPTKKFDQMTPEQTIVGVSQKGVFKIDPRINGKNKIAVDESKDYVGKY NFSSIGTTESGYIAIGSEKGDIKLYDRLGIRAKTAIPSLGQAIKFITTSADGKWLLAT CESTLLLMDLKIKDGKNAGNIGFLKSFPASENVKTYVLKIRPEHSASILTYTKKPIRF TKAYFNTGIGQQEQTIVTSTGPYAISWSLKGILNQDGSNNYPYRIRRYNADVVADNFE FGSDKKVIVALKDDVSLSKVKSFKQPSKGVLMPSASLQDFYG" gene complement(250055..250315) /gene="MRX7" /locus_tag="YNL211C" mRNA complement(250055..250315) /gene="MRX7" /locus_tag="YNL211C" /product="Mrx7p" CDS complement(250055..250315) /gene="MRX7" /locus_tag="YNL211C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene" /codon_start=1 /product="Mrx7p" /protein_id="DAA10345.1" /db_xref="SGD:S000005155" /translation="MPPRSIEEWFYYKLLSSPGFHRFVRKVYRKVNGIKEDPFTDQST AFQYLYKPTPRQKFKALRLLFWDEMRSTFGFRRRLGDRFKKD" rep_origin 250315..250931 /note="ARS1413; Strong origin of replication activated in late S phase" /db_xref="SGD:S000077375" gene 250931..251743 /gene="MER1" /locus_tag="YNL210W" mRNA 250931..251743 /gene="MER1" /locus_tag="YNL210W" /product="Mer1p" CDS 250931..251743 /gene="MER1" /locus_tag="YNL210W" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:10983980]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7891689]" /experiment="EXISTENCE:direct assay:GO:1990446 U1 snRNP binding [PMID:10983980]" /experiment="EXISTENCE:genetic interaction:GO:0007131 reciprocal meiotic recombination [PMID:2659434]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:2659434]" /experiment="EXISTENCE:mutant phenotype:GO:0048026 positive regulation of mRNA splicing, via spliceosome [PMID:10983980]" /note="mRNA-binding protein required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination; Mer1p regulon embraces four essential meiotic pre-mRNAs: REC107, HFM1, AMA1 and SPO22" /codon_start=1 /product="Mer1p" /protein_id="DAA10346.1" /db_xref="SGD:S000005154" /translation="MSNQHSPQPFCLDTKLVKLLEELQEGKQFNNKNIFPEKALYLKL ALDYSFFRKNLLEFCVHLDKIKGVIRPNYDTIYILCLLEVDLLNLVFTDNILEICLPR FVSREDLRVFNNTFYTYHDNRLRILQEDFSQLFKKIKTKASVLCFTVEEIFLTNQEIL PQNSTVAELQKSTNKVQTNGPQRHDFIVTLEIKLNKTQITFLIGAKGTRIESLREKSG ASIKIIPISDKMTAHERNHPESVQQTILISGDLYSIALAVTSIESALITLDL" gene 252059..253900 /gene="SSB2" /locus_tag="YNL209W" /gene_synonym="YG103" mRNA 252059..253900 /gene="SSB2" /locus_tag="YNL209W" /gene_synonym="YG103" /product="Hsp70 family ATPase SSB2" CDS 252059..253900 /gene="SSB2" /locus_tag="YNL209W" /gene_synonym="YG103" /EC_number="3.6.4.10" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:9860955]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:9670014]" /experiment="EXISTENCE:direct assay:GO:0051083 'de novo' cotranslational protein folding [PMID:9670014]" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:20368619]" /experiment="EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:20368619]" /experiment="EXISTENCE:genetic interaction:GO:0042149 cellular response to glucose starvation [PMID:19723765]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:1394434]" /experiment="EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:15456889]" /experiment="EXISTENCE:mutant phenotype:GO:0006452 translational frameshifting [PMID:16607023]" /experiment="EXISTENCE:physical interaction:GO:0002181 cytoplasmic translation [PMID:1394434]" /note="Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication" /codon_start=1 /product="Hsp70 family ATPase SSB2" /protein_id="DAA10347.1" /db_xref="SGD:S000005153" /translation="MAEGVFQGAIGIDLGTTYSCVATYESSVEIIANEQGNRVTPSFV AFTPQERLIGDAAKNQAALNPRNTVFDAKRLIGRRFDDESVQKDMKTWPFKVIDVDGN PVIEVQYLEETKTFSPQEISAMVLTKMKEIAEAKIGKKVEKAVITVPAYFNDAQRQAT KDAGAISGLNVLRIINEPTAAAIAYGLGAGKSEKERHVLIFDLGGGTFDVSLLHIAGG VYTVKSTSGNTHLGGQDFDTNLLEHFKAEFKKKTGLDISDDARALRRLRTAAERAKRT LSSVTQTTVEVDSLFDGEDFESSLTRARFEDLNAALFKSTLEPVEQVLKDAKISKSQI DEVVLVGGSTRIPKVQKLLSDFFDGKQLEKSINPDEAVAYGAAVQGAILTGQSTSDET KDLLLLDVAPLSLGVGMQGDIFGIVVPRNTTVPTIKRRTFTTVSDNQTTVQFPVYQGE RVNCKENTLLGEFDLKNIPMMPAGEPVLEAIFEVDANGILKVTAVEKSTGKSSNITIS NAVGRLSSEEIEKMVNQAEEFKAADEAFAKKHEARQRLESYVASIEQTVTDPVLSSKL KRGSKSKIEAALSDALAALQIEDPSADELRKAEVGLKRVVTKAMSSR" gene 254418..255017 /locus_tag="YNL208W" mRNA 254418..255017 /locus_tag="YNL208W" /product="hypothetical protein" CDS 254418..255017 /locus_tag="YNL208W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /note="hypothetical protein; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10348.1" /db_xref="SGD:S000005152" /translation="MSANEFYSSGQQGQYNQQNNQERTGAPNNGQYGADNGNPNGERG LFSTIVGGSAGAYAGSKVSNNHSKLSGVLGAIGGAFLANKISDERKEHKQQEQYGNSN FGGAPQGGHNNHHRQDNNNNNGGFGGPGGPGGQGFGRQGPQGFGGPGPQEFGGPGGQG FGGPNPQEFGGPGGQGFGGPNPQEFGGQGRQGFNGGSRW" gene 255353..256630 /gene="RIO2" /locus_tag="YNL207W" mRNA 255353..256630 /gene="RIO2" /locus_tag="YNL207W" /product="protein kinase RIO2" CDS 255353..256630 /gene="RIO2" /locus_tag="YNL207W" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:12690111]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12690111|PMID:12612080]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15167894]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12612080]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12612080|PMID:12690111]" /experiment="EXISTENCE:mutant phenotype:GO:0046830 positive regulation of RNA import into nucleus [PMID:12612080]" /note="Essential serine kinase involved in the processing of 20S pre-rRNA; involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p" /codon_start=1 /product="protein kinase RIO2" /protein_id="DAA10349.1" /db_xref="SGD:S000005151" /translation="MKLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMR SQSGTNRAISDLAKLSLISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIG VGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAAN KEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIV DLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDADYYFQRDVDCI RRFFKKKLKYEPKPDSSMLDTEGFGDGYKYAYPDFKRDVKRTDNLDELVQASGFSKKH PGDRGLETAVESMRNAVYNSDDDMSNDEAEEENGEGDYSEEDEYYDSELDNESSEDDS EDAQEEENERIIEALSSGVENLKMDKLGNYILE" gene complement(256788..258155) /gene="RTT106" /locus_tag="YNL206C" mRNA complement(256788..258155) /gene="RTT106" /locus_tag="YNL206C" /product="Rtt106p" CDS complement(256788..258155) /gene="RTT106" /locus_tag="YNL206C" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:20007951]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:18662540|PMID:16157874|PMID:20007951]" /experiment="EXISTENCE:genetic interaction:GO:0006335 DNA replication-dependent chromatin assembly [PMID:18662540]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:18708354]" /experiment="EXISTENCE:genetic interaction:GO:0031507 heterochromatin formation [PMID:20007951|PMID:17410207]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:19683497]" /experiment="EXISTENCE:mutant phenotype:GO:0003690 double-stranded DNA binding [PMID:20007951]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:18708354]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:18708354]" /experiment="EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:17410207]" /experiment="EXISTENCE:mutant phenotype:GO:0042393 histone binding [PMID:20007951]" /experiment="EXISTENCE:physical interaction:GO:0042393 histone binding [PMID:16157874]" /note="Histone chaperone; involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition; interacts physically and functionally with Chromatin Assembly Factor-1 (CAF-1)" /codon_start=1 /product="Rtt106p" /protein_id="DAA10350.1" /db_xref="SGD:S000005150" /translation="MSKLFLDELPESLSRKIGTVVRVLPSSLEIFEELYKYALNENSN DRSGRHKKPRIDVSSDLLKTDEISETNTIFKLEGVSVLSPLRKKLDLVFYLSNVDGSP VITLLKGNDRELSIYQLNKNIKMASFLPVPEKPNLIYLFMTYTSCEDNKFSEPVVMTL NKENTLNQFKNLGLLDSNVTDFEKCVEYIRKQAILTGFKISNPFVNSTLVDTDAEKIN SFHLQCHRGTKEGTLYFLPDHIIFGFKKPILLFDASDIESITYSSITRLTFNASLVTK DGEKYEFSMIDQTEYAKIDDYVKRKQMKDKSMSEELKAKSKSKGQATDGTADQPSILQ EATRQMQDEKKAGVFSDDDEENDQNFEAESDLSDGSGQESSDGAEDGEEAEEDDEEDD EEEDKKGQSALNRDNSFASINGQPEQELQYKEFKEPLELEDIPIEIDNDDDEDDEDGS GVEYD" gene complement(258375..259277) /gene="SPS18" /locus_tag="YNL204C" /gene_synonym="SPX18" mRNA complement(258375..259277) /gene="SPS18" /locus_tag="YNL204C" /gene_synonym="SPX18" /product="Sps18p" CDS complement(258375..259277) /gene="SPS18" /locus_tag="YNL204C" /gene_synonym="SPX18" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:7969036]" /note="hypothetical protein, contains a putative zinc-binding domain; expressed during sporulation; SPS18 has a paralog, GCS1, that arose from the whole genome duplication" /codon_start=1 /product="Sps18p" /protein_id="DAA10351.1" /db_xref="SGD:S000005148" /translation="MRLFENSKDMENRKRLLRAKKAAGNNNCFECKSVNPQFVSCSFG IFICVNCANLLRGMGTNIFCVKSITMDNFEEKDVRRVEKSGNNRFGSFLSKNGILQNG IPLREKYDNLFAKSYKRRLANEVRSNDINRNMYLGFNNFQQYTNGATSQIRDRTLREI SNNSNASEGAEFVLPEKVLGSDNFQDCERFPACLSSERNLDENNVTSATSTLTIEKFQ NDPIGTISRSWQLLSDALYKSYEDFKGSVVQPTIENIQQRNLPNDIKRSFVHFNEKLH ETPHLPSPVFSCFTGGDILPPEFN" gene 259578..260456 /gene="SPS19" /locus_tag="YNL202W" /gene_synonym="SPX19" mRNA 259578..260456 /gene="SPS19" /locus_tag="YNL202W" /gene_synonym="SPX19" /product="2,4-dienoyl-CoA reductase (NADPH)" CDS 259578..260456 /gene="SPS19" /locus_tag="YNL202W" /gene_synonym="SPX19" /EC_number="1.3.1.124" /experiment="EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:9268358]" /experiment="EXISTENCE:direct assay:GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity [PMID:9268358]" /experiment="EXISTENCE:direct assay:GO:0009062 fatty acid catabolic process [PMID:9268358]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:7969036]" /note="Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate" /codon_start=1 /product="2,4-dienoyl-CoA reductase (NADPH)" /protein_id="DAA10352.1" /db_xref="SGD:S000005146" /translation="MNTANTLDGKFVTEGSWRPDLFKGKVAFVTGGAGTICRVQTEAL VLLGCKAAIVGRDQERTEQAAKGISQLAKDKDAVLAIANVDVRNFEQVENAVKKTVEK FGKIDFVIAGAAGNFVCDFANLSPNAFKSVVDIDLLGSFNTAKACLKELKKSKGSILF VSATFHYYGVPFQGHVGAAKAGIDALAKNLAVELGPLGIRSNCIAPGAIDNTEGLKRL AGKKYKEKALAKIPLQRLGSTRDIAESTVYIFSPAASYVTGTVLVVDGGMWHLGTYFG HELYPEALIKSMTSKL" gene complement(260627..263203) /gene="PSY2" /locus_tag="YNL201C" mRNA complement(260627..263203) /gene="PSY2" /locus_tag="YNL201C" /product="Psy2p" CDS complement(260627..263203) /gene="PSY2" /locus_tag="YNL201C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019888 protein phosphatase regulator activity [PMID:17517611]" /experiment="EXISTENCE:direct assay:GO:0030289 protein phosphatase 4 complex [PMID:16299494|PMID:17517611]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:15598824]" /experiment="EXISTENCE:mutant phenotype:GO:0030289 protein phosphatase 4 complex [PMID:16299494]" /experiment="EXISTENCE:mutant phenotype:GO:0051598 meiotic recombination checkpoint signaling [PMID:20951350]" /experiment="EXISTENCE:mutant phenotype:GO:1902660 negative regulation of glucose mediated signaling pathway [PMID:24277933]" /experiment="EXISTENCE:mutant phenotype:GO:2000002 negative regulation of DNA damage checkpoint [PMID:17517611|PMID:16299494]" /experiment="EXISTENCE:mutant phenotype:GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining [PMID:24498054]" /note="Subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form the active complex, Psy4p may provide additional substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3" /codon_start=1 /product="Psy2p" /protein_id="DAA10353.1" /db_xref="SGD:S000005145" /translation="MSLPGTPTTSPTPMDEDTEQAVSVNTEPKRVKVYILENNEWKDT GTGFCIGEVDEGKFAYLVVSDEDSPTETLLKSKLEGNIEYQRQEETLIVWKDLGGKDI ALSFEESMGCDTLCEFIVHVQRNIESNISLVTVKSSDNGLGSVHDIITGPVTLPSNDQ QQNSQTLLEALKILNENTSFDFLKNETIEFILQSNYIDTLISHFHKAEEEKIPKDLFL LSNIIKTLILYNKRDILESMVEDDRIMGIVGILEYDTEYPTSKANHRKYLGSKGPNFK EVIPLENEDLKIIMKKCFRLQFLKDVVLVRFLDDHNFNLISEIVMDLETCIIDFLQVG TFLDRLIELYDTKTLPESSSEKEKFVQKRKDGIRLLQQCVQMSINLDAVDRSKFYKTL VRKGLFKVLDYAFHMETDSNVRILATDTIITIIEHDILLIHNVQNEDSFKRQHKSAPD DKSSHRKYPQDYSSSTDSKLLLILSTILLSDRSPGLREQVVQALNTLLHPEGCVGNGE GSYDLMGRSNYEAKNTSEDFPSFSYGLNSDSINLNNYHYSSDEMNNLEPESESEFQVM EYFANFYNKIAPILFGPLIKKDITTEMAEIDGQIEKVTKDDLLLIHLVKLVSFVCTEH DRVLSRRFILENGILDSVSKLIGGNHMMQLRLTAVRCIKNLMCLDDKYYHRYMISKNL YAPVFKLFQENIDKNNLANSCIQDFFRIIITECRAYQSDGHNRKEKTNGSYDGNGNDV KTNVNNNRTNFTILNKYLVQTYGDVLRKATDIPFIQDMLETGEENQPDHSSFENSIEG GNDISVNMSTDGFASNHLEDIDIKNVKRLHSEIEHFENDPHYSGDQLAFKKSVDQMNA ST" gene complement(263713..264453) /gene="NNR1" /locus_tag="YNL200C" mRNA complement(263713..264453) /gene="NNR1" /locus_tag="YNL200C" /product="NADHX epimerase" CDS complement(263713..264453) /gene="NNR1" /locus_tag="YNL200C" /EC_number="5.1.99.6" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0046496 nicotinamide nucleotide metabolic process [PMID:21994945]" /experiment="EXISTENCE:direct assay:GO:0052856 NAD(P)HX epimerase activity [PMID:21994945]" /note="NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /codon_start=1 /product="NADHX epimerase" /protein_id="DAA10354.1" /db_xref="SGD:S000005144" /translation="MSTLKVVSSKLAAEIDKELMGPQIGFTLQQLMELAGFSVAQAVC RQFPLRGKTETEKGKHVFVIAGPGNNGGDGLVCARHLKLFGYNPVVFYPKRSERTEFY KQLVHQLNFFKVPVLSQDEGNWLEYLKPEKTLCIVDAIFGFSFKPPMREPFKGIVEEL CKVQNIIPIVSVDVPTGWDVDKGPISQPSINPAVLVSLTVPKPCSSHIRENQTTHYVG GRFIPRDFANKFGFEPFGYESTDQILKL" gene complement(264926..266530) /gene="GCR2" /locus_tag="YNL199C" mRNA complement(264926..266530) /gene="GCR2" /locus_tag="YNL199C" /product="Gcr2p" CDS complement(264926..266530) /gene="GCR2" /locus_tag="YNL199C" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:27190003]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15817685]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15817685]" /experiment="EXISTENCE:direct assay:GO:0060196 positive regulation of antisense RNA transcription [PMID:27190003]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11333224]" /experiment="EXISTENCE:genetic interaction:GO:0003712 transcription coregulator activity [PMID:11333224]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:27190003]" /experiment="EXISTENCE:mutant phenotype:GO:0006110 regulation of glycolytic process [PMID:11333224|PMID:2247062]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:27190003|PMID:10455229|PMID:15789351|PMID:2247062|PM ID:9335590|PMID:11333224]" /experiment="EXISTENCE:mutant phenotype:GO:0060196 positive regulation of antisense RNA transcription [PMID:27190003]" /experiment="EXISTENCE:mutant phenotype:GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:11333224]" /note="Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p" /codon_start=1 /product="Gcr2p" /protein_id="DAA10355.1" /db_xref="SGD:S000005143" /translation="MHHQTKLDVFIIRAYNLLSNESVISGASLQSVTNSPQTTTNTPS GMVNGAVGTGIANPTGLMGSDSTPNIDEIITSTGSNALTKTNSDSANGTPNGNSSSTS AISNASNPATTGNNASSSATSNGIYTQAQYSQLFAKISKLYNATLSSGSIDDRSTSPK SAIELYQRFQQMIKELELSFDASPYAKYFRRLDGRLWQIKTDSELENDELWRLVSMSI FTVFDPQTGQILTQGRRKGNSLNTSTKGSPSDLQGINNGNNNGNNGNIGNGSNIKNYG NKNMPNNRTKKRGTRVAKNAKNGKNNKNSNKERNGITDTSAFSNTTISNPGTNMLFDP SLSQQLQKRLQTLSQDVNSRSLTGYYTQPTSPGSGGFEFGLSHADLNPNASSNTMGYN TMSNNGSHSWKRRSLGSLDVNTLDDEAVEELLQLTNTSKRQRPMTTAAEGALINDGPD TNLNANNTQMKVDLNPSNSMGPIDTEAVIRPLKEAYDAIISEKGQRIVQLERELELQR QETQWLRKMLIEDMGCVRSMLRDLQR" gene complement(267608..269593) /gene="WHI3" /locus_tag="YNL197C" mRNA complement(267608..269593) /gene="WHI3" /locus_tag="YNL197C" /product="mRNA-binding protein WHI3" CDS complement(267608..269593) /gene="WHI3" /locus_tag="YNL197C" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:24386402]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:11691832|PMID:24386402]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11691832]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:35085498]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:24386402|PMID:26777405|PMID:24386330]" /experiment="EXISTENCE:genetic interaction:GO:0007089 traversing start control point of mitotic cell cycle [PMID:11691832]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:14685274]" /experiment="EXISTENCE:mutant phenotype:GO:0003729 mRNA binding [PMID:11691832]" /experiment="EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:11691832]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:14685274|PMID:9055077]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0061013 regulation of mRNA catabolic process [PMID:24386330]" /experiment="EXISTENCE:mutant phenotype:GO:0061157 mRNA destabilization [PMID:24386402]" /note="RNA binding protein that modulates mRNA stability; regulates cell cycle, sister chromatid cohesion, and stress response genes; modulates stability and translational efficiency of CLN3 mRNA; colocalizes with P-bodies/stress granules to regulate target mRNAs; regulates cell fate and critical cell size for Start passage; regulates ploidy; self-templating mnemon that forms inactive super-assemblies, preventing G1 arrest in mother cells after unsuccessful mating and causing sterility in old cells" /codon_start=1 /product="mRNA-binding protein WHI3" /protein_id="DAA10356.1" /db_xref="SGD:S000005141" /translation="MQSSVYFDQTGSFASSSDNVVSSTTNTHNISPSHRSSLNLNTTS HPHEASGRGSASGELYLNDTNSPLAISSMLNTLALGSMPQDIASSNISNHDNNIKGSY SLKLSNVAKDITLRECYAIFALAEGVKSIELQKKNSSSSITSASLEDENDIFIIARFE LLNLAINYAVILNSKNELFGPSFPNKTTVEIIDDTTKNLVSFPSSAIFNDTSRLNKSN SGMKRPSLLSQRSRFSFSDPFSNDSPLSQQQSQQQQQQPQQPQQHSTQKHSPQQCNQQ QVNSSIPLSSQGQVIGLHSNHSHQDLSVESTIQTSDIGKSFLLRDNTEINEKIWGTSG IPSSINGYMSTPQPSTPTLEWGNTSASQHGSSFFLPSAASTAIAPTNSNTSANANASS NNGASNNGANQALSASSQQPMMQIGNTINTSLTSSNSLPPYGLMSSQSQHISNMVNTS DMNITPQKQNRFMQQPQPEHMYPVNQSNTPQKVPPARLSSSRNSHKNNSTTSLSSNIT GSASISQADLSLLARIPPPANPADQNPPCNTLYVGNLPSDATEQELRQLFSGQEGFRR LSFRNKNTTSNGHSHGPMCFVEFDDVSFATRALAELYGRQLPRSTVSSKGGIRLSFSK NPLGVRGPNSRRGGSGNPNPNVNMLSSYNSNVGHIKN" gene complement(270275..271171) /gene="SLZ1" /locus_tag="YNL196C" mRNA complement(270275..271171) /gene="SLZ1" /locus_tag="YNL196C" /product="Slz1p" CDS complement(270275..271171) /gene="SLZ1" /locus_tag="YNL196C" /experiment="EXISTENCE:direct assay:GO:0036396 RNA N6-methyladenosine methyltransferase complex [PMID:22685417]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:22685417]" /experiment="EXISTENCE:mutant phenotype:GO:2000221 negative regulation of pseudohyphal growth [PMID:22685417]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:22685417]" /experiment="EXISTENCE:physical interaction:GO:0036396 RNA N6-methyladenosine methyltransferase complex [PMID:22685417]" /note="Sporulation-specific protein with a leucine zipper motif; subunit of the MIS complex which controls mRNA methylation during the induction of sporulation; homologous to human ZCH13H3, a subunit of the mammalian m6A methyltransferase complex" /codon_start=1 /product="Slz1p" /protein_id="DAA10357.1" /db_xref="SGD:S000005140" /translation="MMNKVDQIIGYKKYEVKLPKDRQVKKNKSKGGNVDQIDTKREKD KMRAFGEERKKFLDKMAKNKKKNTSRKDREKPKEVEKENYKREDKRLKEQKKLSLAKE FRFKEPNSEAINQNTAAENGKPKPQTGLDFDIDHQTVSKIMIDQAIQTSSPLNVQLTE LFNDNVLDVSKDSQFVLQDMEFTSWERRWSNCSTTSNATTVSSVPDPKYNINYNDITS FNSVALITEDLNISASSNGLHERGKKLLQQEMEYSNKVKNVTIGLERLCMDEKPVPDA GITMQQASRWSEFPTCCDQAAI" gene complement(271523..272308) /locus_tag="YNL195C" mRNA complement(271523..272308) /locus_tag="YNL195C" /product="hypothetical protein" CDS complement(271523..272308) /locus_tag="YNL195C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /note="hypothetical protein; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL195C has a paralog, HBT1, that arose from the whole genome duplication" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10358.1" /db_xref="SGD:S000005139" /translation="MLGLGQSAQAYASDDALNMNQAKDKTYSVPGCGRASDLKYPHRD GHSSSHEQRSGILPTECPGPTLNTGAGSIGIPGCGKVTNRVVSDYNKNARSTLANFDS SKMTEARMNSKNVPIGCQDTSDPHFNGPIDQHVPGAGSPQSQPHHIDAWNSVSSRRAD NNNQDMMDPQTASSDRYNEKMMREENSGVSASSYTTKVQGYPASIPSFNQETEEKETY AYGVGDRHNVPRNQIMDETNPSANVLNATDHSISHPENKVLHK" gene complement(272710..273615) /locus_tag="YNL194C" mRNA complement(272710..273615) /locus_tag="YNL194C" /product="hypothetical protein" CDS complement(272710..273615) /locus_tag="YNL194C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:11784867]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11784867]" /note="Integral membrane protein; required for sporulation and plasma membrane sphingolipid content; similar to SUR7; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate; YNL194C has a paralog, FMP45, that arose from the whole genome duplication" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10359.1" /db_xref="SGD:S000005138" /translation="MSYKKFVYFINLFFLLGATLLTFFLILAGGRTTGVLKNFYWFQA STSGFNSAPSVTRWYNYNWCGWESRGIAVNCSSKMAAQPFSPRDNFGSSPLMPSTFLN NRNAYYYLSRVGWAMLLIGLFFLLITLVSVIASLIRYNRRTAALATAMSWITLFFITL SACLYTGCYAKAVKAFHHENRDARLGPKNFGLIWTTVFLLIVNAICCTIMVATHKRNE YIYDRSFASTKTVDSQTPTPVPTNGGIPSSVPVTEVQQSQSHQNHRFFKKLRTKKRTV TSAGDEPDRVQEERVYTEQNVPVVS" gene 274368..276044 /locus_tag="YNL193W" mRNA 274368..276044 /locus_tag="YNL193W" /product="hypothetical protein" CDS 274368..276044 /locus_tag="YNL193W" /note="hypothetical protein; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10360.2" /db_xref="SGD:S000005137" /translation="MGPPKNFKHFSKSNKHKKEQKALITQEDFYLAAIDCEEQADRWL LSDIKKCLRFYLKALEHYENGLTALDSTQEGKYNIYYNETRLFLQIYTDYLANNGYIN ILQYVKMDDMPDLSNLVLSLPQIIQRFEIVYETFPEQRTWDLQFNLLTCYLTLIESLD DTVSPTVAMEGADILTLTNKYIEIFQHLVNYLLQELQNWSENAEQDSDDTDTELQRDT LDEDAMQVTRDGSGIRTNGPVQPPAEVMDVSEQVTPSSLTEVLANSLKFNHALMELVI ESKISIEKNVETKILNPIQINFLEDTTNKFYLQLRDIIDSISAAIPLDLKEIGLAKTL IEGLNIISSGTFESLQDFVLQTVSFTDLLDEKDVQGKIDLSLIRVDIVEFAILCLNDY SSDASWKLSGLLTKVLTEARTLLTDYRNQILFLKNQTLNEQLSHVVFQLCDVLVNSSD NELRRYAIKESTEKSQKTPGGAHTLNILMKNANVFLNNAVAISSKQCGLQETIIDKLK RNYIHNQAKERLLFLQRLEQKSNEDDGTSASPTAMTFDMPPEHPFYSHYR" gene 276502..279897 /gene="CHS1" /locus_tag="YNL192W" /gene_synonym="USA4" mRNA 276502..279897 /gene="CHS1" /locus_tag="YNL192W" /gene_synonym="USA4" /product="chitin synthase CHS1" CDS 276502..279897 /gene="CHS1" /locus_tag="YNL192W" /gene_synonym="USA4" /EC_number="2.4.1.16" /experiment="EXISTENCE:direct assay:GO:0004100 chitin synthase activity [PMID:7952171]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8970154]" /experiment="EXISTENCE:direct assay:GO:0045009 chitosome [PMID:8970154]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:2523889]" /note="Chitin synthase I; requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor" /codon_start=1 /product="chitin synthase CHS1" /protein_id="DAA10361.2" /db_xref="SGD:S000005136" /translation="MSDQNNRSRNEYHSNRKNEPSYELQNAHSGLFHSSNEELTNRNQ RYTNQNASMGSFTPVQSLQFPEQSQQTNMLYNGDDGNNNTINDNERDIYGGFVNHHRQ RPPPATAEYNDVFNTNSQQLPSEHQYNNVPSYPLPSINVIQTTPELIHNGSQTMATPI ERPFFNENDYYYNNRNSRTSPSIASSSDGYADQEARPILEQPNNNMNSGNIPQYHDQP FGYNNGYHGLQAKDYYDDPEGGYIDQRGDDYQINSYLGRNGEMVDPYDYENSLRHMTP MERREYLHDDSRPVNDGKEELDSVKSGYSHRDLGEYDKDDFSRDDEYDDLNTIDKLQF QANGVPASSSVSSIGSKESDIIVSNDNLTANRALKRSGTEIRKFKLWNGNFVFDSPIS KTLLDQYATTTENANTLPNEFKFMRYQAVTCEPNQLAEKNFTVRQLKYLTPRETELML VVTMYNEDHILLGRTLKGIMDNVKYMVKKKNSSTWGPDAWKKIVVCIISDGRSKINER SLALLSSLGCYQDGFAKDEINEKKVAMHVYEHTTMINITNISESEVSLECNQGTVPIQ LLFCLKEQNQKKINSHRWAFEGFAELLRPNIVTLLDAGTMPGKDSIYQLWREFRNPNV GGACGEIRTDLGKRFVKLLNPLVASQNFEYKMSNILDKTTESNFGFITVLPGAFSAYR FEAVRGQPLQKYFYGEIMENEGFHFFSSNMYLAEDRILCFEVVTKKNCNWILKYCRSS YASTDVPERVPEFILQRRRWLNGSFFASVYSFCHFYRVWSSGHNIGRKLLLTVEFFYL FFNTLISWFSLSSFFLVFRILTVSIALAYHSAFNVLSVIFLWLYGICTLSTFILSLGN KPKSTEKFYVLTCVIFAVMMIYMIFCSIFMSVKSFQNILKNDTISFEGLITTEAFRDI VISLGSTYCLYLISSIIYLQPWHMLTSFIQYILLSPSYINVLNIYAFCNVHDLSWGTK GAMANPLGKINTTEDGTFKMEVLVSSSEIQANYDKYLKVLNDFDPKSESRPTEPSYDE KKTGYYANVRSLVIIFWVITNFIIVAVVLETGGIADYIAMKSISTDDTLETAKKAEIP LMTSKASIYFNVILWLVALSALIRFIGCSIYMIVRFFKKVTFR" rep_origin 279982..280071 /note="ARS1414; ARS activated in mid-S phase" /db_xref="SGD:S000077376" gene 280432..281505 /gene="DUG3" /locus_tag="YNL191W" mRNA 280432..281505 /gene="DUG3" /locus_tag="YNL191W" /product="glutamine amidotransferase subunit DUG3" CDS 280432..281505 /gene="DUG3" /locus_tag="YNL191W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:17179087]" /experiment="EXISTENCE:direct assay:GO:0006751 glutathione catabolic process [PMID:22277648]" /experiment="EXISTENCE:direct assay:GO:0036374 glutathione hydrolase activity [PMID:22277648]" /experiment="EXISTENCE:direct assay:GO:0061672 glutathione hydrolase complex [PMID:22277648]" /experiment="EXISTENCE:genetic interaction:GO:0008233 peptidase activity [PMID:17179087]" /experiment="EXISTENCE:genetic interaction:GO:0008242 omega peptidase activity [PMID:17179087]" /experiment="EXISTENCE:mutant phenotype:GO:0006751 glutathione catabolic process [PMID:22277648|PMID:17179087]" /note="Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)" /codon_start=1 /product="glutamine amidotransferase subunit DUG3" /protein_id="DAA10362.1" /db_xref="SGD:S000005135" /translation="MCRFLIFKGKQPIRLSHLLTRPAHSIINQSFDSRLRLDRRRPMN GDGFGVAYYPLDTELSEDGPCLFKAITPAWNNQNLSTLAEKTKSDLVFAHVRASTYGV LSETNCHPFTYHSLCFMHNGGISNFKGIKRKLLNHIKDEYLNFIQGSTDSECAFALFL DTLDKLGYDPKKQDGDFGNVALRKAMLRTIDYIRDWTKEANKDEAHVEPSLLNFAVTD GSTVVVSRYITSKTDEAASLHFSCGSSFVETSPGEYRVERLDRNQDVIMVASEPLTFE RGDWTAVPTNSILTIKKQTILLHPIIDEYYQEDPLYLRSSTLAESKGLMGSIPLAKAV EKNVPPLEREGRTRPPTAVAHIA" gene 282395..283009 /locus_tag="YNL190W" mRNA 282395..283009 /locus_tag="YNL190W" /product="hypothetical protein" CDS 282395..283009 /locus_tag="YNL190W" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:mutant phenotype:GO:0042631 cellular response to water deprivation [PMID:22442684]" /note="Hydrophilin essential in desiccation-rehydration process; cell wall protein; contains a putative GPI-attachment site" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10363.1" /db_xref="SGD:S000005134" /translation="MKFSSVTAITLATVATVATAKKGEHDFTTTLTLSSDGSLTTTTS THTTHKYGKFNKTSKSKTPNHTGTHKYGKFNKTSKSKTPNHTGTHKYGKFNKTSKSKT PNHTGTHKYGKFNKTSKSKTPNHTGTHKYGKFNKTSKSKTPNHTGTHKYGKFNKTKHD TTTYGPGEKARKNNAAPGPSNFNSIKLFGVTAGSAAVAGALLLL" gene 284260..285888 /gene="SRP1" /locus_tag="YNL189W" /gene_synonym="KAP60" /gene_synonym="SCM1" mRNA 284260..285888 /gene="SRP1" /locus_tag="YNL189W" /gene_synonym="KAP60" /gene_synonym="SCM1" /product="karyopherin alpha" CDS 284260..285888 /gene="SRP1" /locus_tag="YNL189W" /gene_synonym="KAP60" /gene_synonym="SCM1" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:10725229]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10725229]" /experiment="EXISTENCE:direct assay:GO:0042564 NLS-dependent protein nuclear import complex [PMID:19141610]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:19046973]" /experiment="EXISTENCE:direct assay:GO:0061608 nuclear import signal receptor activity [PMID:7622450]" /experiment="EXISTENCE:mutant phenotype:GO:0006607 NLS-bearing protein import into nucleus [PMID:19141610]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:16929305]" /experiment="EXISTENCE:mutant phenotype:GO:0031144 proteasome localization [PMID:25274630]" /note="Karyopherin alpha homolog; forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; involved in cotranslational protein degradation; binds ribosome-bound nascent polypeptides; Srp1p and Sts1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation" /codon_start=1 /product="karyopherin alpha" /protein_id="DAA10364.1" /db_xref="SGD:S000005133" /translation="MDNGTDSSTSKFVPEYRRTNFKNKGRFSADELRRRRDTQQVELR KAKRDEALAKRRNFIPPTDGADSDEEDESSVSADQQFYSQLQQELPQMTQQLNSDDMQ EQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIAS GTSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAME PILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVD ACWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQT QVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLL EVAEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLD ALENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETY FGEEEDAVDETMAPQNAGNTFGFGSNVNQQFNFN" gene 286308..287609 /gene="KAR1" /locus_tag="YNL188W" mRNA 286308..287609 /gene="KAR1" /locus_tag="YNL188W" /product="Kar1p" CDS 286308..287609 /gene="KAR1" /locus_tag="YNL188W" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005825 half bridge of spindle pole body [PMID:10428957]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:1607389]" /experiment="EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:3030557]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:8188750|PMID:10428957]" /note="Protein involved in karyogamy and spindle pole body duplication; involved in karyogamy during mating; involved in centrosome separation and duplication during mitosis; localizes to the half-bridge of the spindle pole body; interacts with Spc72p during karyogamy; also interacts with Cdc31p; essential gene" /codon_start=1 /product="Kar1p" /protein_id="DAA10365.1" /db_xref="SGD:S000005132" /translation="MNVTSPKDGNHSFSKKNRFNTNKPRFHKLNEQAQSINLPEDRDS IVSSNTTSIMTDDAFDYNEGIASRTKNINSDSDRSNDTIKQNNYNKRETGYNPFYNGS GINQRYTQFRKREFEPTLAENKAEEYISDEDNVKIDEDNIENELQFTPKIKEASILRS SLLGQRNVLNTRNPKSKESHIKVKPIINNKSSSQRKSSAALRKQLGKPLPLPYLNSPN SDSTPTLQRKEEVFTDEVLQKKRELIESKWHRLLFHDKKMVEKKLESLREYERKRMPP RGTDVSSSEQDNSFKISTPTKSYVSLEQKPLPNLSAMNNFNDVTDNKEKEETNNNILK FQAQRDPLQILQSEIEMHTKKLDTIIELLKDDTDSKEKRKVVTNDNAAPEQMVNKGWR KNVMMIYKKSGNIMKKYREYFLWTICILILLYCNIYVYYRF" gene 287994..289067 /gene="SWT21" /locus_tag="YNL187W" mRNA 287994..289067 /gene="SWT21" /locus_tag="YNL187W" /product="Swt21p" CDS 287994..289067 /gene="SWT21" /locus_tag="YNL187W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19451230]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:19451230]" /note="Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats" /codon_start=1 /product="Swt21p" /protein_id="DAA10366.1" /db_xref="SGD:S000005131" /translation="MEKKVICQDIFWSCDGTSFVSVHNDFGIRQYLVPEESNTDKLNR NLLLPFTRFFRNQSIVSCAIDPFYTLYNENSDRLAGDRIVVGGKNFPLQLYSLMDGQC ILSYDTMNKINGEYETVYSVKIDVESRVYTGSCRNKVAIYDKSRRDAVWMNQSTKKAS KGRQSIISCFEEQPMGGQALSRGSLLCGSYANEMFQVDCRHQRLERLNYTRTVAGGIV QILTSDNGRYVYVVRRNSDAISIYDRRNLQHELNVLRLPFRIHHNSAKLKAYIDTAYG LSMGTPQGTILNWGRDLVEFGGVPSHNSVEDPLITSIPPESEWRTNLDSTIPATVVKN CPGDPELFALSHGGTISLCRFGG" gene 289498..291876 /gene="UBP10" /locus_tag="YNL186W" /gene_synonym="DOT4" mRNA 289498..291876 /gene="UBP10" /locus_tag="YNL186W" /gene_synonym="DOT4" /product="ubiquitin-specific protease UBP10" CDS 289498..291876 /gene="UBP10" /locus_tag="YNL186W" /gene_synonym="DOT4" /EC_number="3.4.19.12" /experiment="EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:10490600]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10490600|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22902402]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:31665643]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:15721261|PMID:26587833]" /experiment="EXISTENCE:mutant phenotype:GO:0033567 DNA replication, Okazaki fragment processing [PMID:39294185]" /note="Ubiquitin-specific protease, deubiquitinates Ub-protein moieties; interacts with proteins that function in rRNA production and ribosome biogenesis via its intrinsically disordered regions; stabilizes Rpa190p by deubiquitination; controls PCNA deubiquitylation; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p, possibly other transporters; localized to the nucleolus; null mutant phenotypes are functionally complemented by human USP36" /codon_start=1 /product="ubiquitin-specific protease UBP10" /protein_id="DAA10367.2" /db_xref="SGD:S000005130" /translation="MTTQESIKPLVDRILSNPLQFNAAMISNKSNNNDTSAAPENSSY IVIGKQHNNNSNSTAIAATAESKQIKENNLIDRPNGKKTNTVPKSMAEALLLYTSKND KDAADATGAKKSAELSTELSTEPPSSSSEDDKVGKEEEEEGEIFHEARDYVEPRKASL KERDNADKGDGEDIGEDIGEDIGEDIGEDIGEDIGENLGSPLATIDDSSNENEKEKRK ELSTSISSDDEIEDDEDEDDMDYDSSAMEKELPEEEENDSSSKISEGEKKSLYQDLME NSTVEVNRYEPVNNTKENGNRNPKGEEEEEEEEELKHKSRSITPPVTISNLSNFYQFN ENINDRGSLNSTRIVKNWGDKFTNLKPRGLLNHGVTCYTNAAVQAMLHIPSIQHYLFD ILMGKYDSTISKNSVSYTLAETSKKMWLPVSKNPRKNVSASYINPKHLISRLDDINCM MSEWQQEDSHEYFMSLMSRLQEDSVPKGHKLIESIIYDIFGGLLKQIVTCKSCGSISK TEQPFYDLSLHLKGKKKLDPNSDLSSDSINGTSATTSTTTSNAATKPSLSSSSSVNLN NGSPFAAASDLSSANRRFSIEKSIKDFFNPELIKVDKEQKGYVCEKCHKTTNAVKHSS ILRAPETLLVHLKKFRFNGTSSSKMKQAVSYPMFLDLTEYCESKELPVKYQLLSVVVH EGRSLSSGHYIAHCKQPDGSWATYDDEYINIISERDVLKEPNAYYLLYTRLTPKSVPL PLAKSAMATGNVTSKSKQEQAVNEPNNRPLKINSKKNNRKKWKKNKKRKFTK" gene complement(292193..292669) /gene="MRPL19" /locus_tag="YNL185C" /gene_synonym="uL11m" mRNA complement(292193..292669) /gene="MRPL19" /locus_tag="YNL185C" /gene_synonym="uL11m" /product="mitochondrial 54S ribosomal protein YmL19" CDS complement(292193..292669) /gene="MRPL19" /locus_tag="YNL185C" /gene_synonym="uL11m" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978]" /note="Mitochondrial ribosomal protein of the large subunit" /codon_start=1 /product="mitochondrial 54S ribosomal protein uL11m MRPL19" /protein_id="DAA10368.1" /db_xref="SGD:S000005129" /translation="MSQAAKNVIVKLIVGAGQAAPSPPVGPALGSKGIKAIDFCKEFN ARSANYQPGVPVPVLITIKPDRTFTFEMKSPPTGYLLLKALKMDKGHGQPNVGTMLGS APAKGPTRALGELSLKHVYEIAKIKKSDERHSLLEMEGIVKSIVGVAKSMGIKVVP" gene complement(292557..292883) /locus_tag="YNL184C" mRNA complement(292557..292883) /locus_tag="YNL184C" /product="hypothetical protein" CDS complement(292557..292883) /locus_tag="YNL184C" /note="hypothetical protein; expressed at both mRNA and protein levels" /codon_start=1 /product="hypothetical protein" /protein_id="DAA35132.1" /db_xref="SGD:S000005128" /translation="MKRVTLIVLPRRQFPFLKFHSKEALESAVNLQLIRRKKSVNIQI DSVTFCIYFCLLYFRTLEYHRGTISLHNVTGSKKRDSKANSRSRPSGTITSRGARIGL QGYKSH" gene complement(293137..295509) /gene="NPR1" /locus_tag="YNL183C" mRNA complement(293137..295509) /gene="NPR1" /locus_tag="YNL183C" /product="serine/threonine protein kinase NPR1" CDS complement(293137..295509) /gene="NPR1" /locus_tag="YNL183C" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:19780626]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17095607]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:17095607]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22118465]" /experiment="EXISTENCE:mutant phenotype:GO:0045806 negative regulation of endocytosis [PMID:22118465]" /experiment="EXISTENCE:mutant phenotype:GO:0090153 regulation of sphingolipid biosynthetic process [PMID:23363605]" /note="Protein kinase; stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis by phosphorylating Ldb19p; positively regulates activity of the three Mep ammonium transport proteins; mediates inhibitory phosphorylation of Mep2p and Par32p; TOR complex negatively regulates Npr1p activity; NPR1 has a paralog, PRR2, that arose from the whole genome duplication" /codon_start=1 /product="serine/threonine protein kinase NPR1" /protein_id="DAA10369.1" /db_xref="SGD:S000005127" /translation="MSSLTRLLQEKRKNETSNSSPRTSADTLTTTPESQSLDLHSRNK SSSHIGSVSNSSSSDRNRANVPVPGSVTTVTQIYSEEDSSSTAGSSLDDRNQFSSSFL NANFAHTASFYGTSAQSRDRFGSLINDQGTAGLSSHGGSFAAQNRITSRLSTTSHTSG RAIPSLSSSIPYSVPNSNKDNNSSNSNSSSLSSSWLETYAGGMPNNISAIDSNVISSP KVDSVEPRFVISKQKLQKASMDSNNANATQSRSISRSGSFSSQLGNFFFSKNSKESSN SNSAGMSFSANSNGPSPNIKNPNVTNGSTPIPKPIRARQSSIYSASRQPTGSYTDNFY GSPSSVHDHLPPSQSVPRSQHSSIGDLKRFFKKSSNSNLSSNSNNVIPNGSPLSSGIA VPSHSHSSSHFAAGNNSYSTSYNGNGDTIYSHSHGGSGIPFSKRYIKTGADLGAGAGG SVKLAQRISDNKIFAVKEFRTKFENESKRDYVKKITSEYCIGTTLNHPNIIETIEIVY ENDRILQVMEYCEYDLFAIVMSNKMSYEEICCCFKQILTGVQYLHSIGLAHRDLKLDN CVINEKGIVKLIDFGAAVVFSYPFSKNLVEASGIVGSDPYLAPEVCIFAKYDPRPVDI WSSAIIFACMILKKFPWKIPKLRDNSFKLFCSGRDCDSLSSLVTRTPDPPSYDESHST EKKKPESSSNNVSDPNNVNIGPQRLLHSLPEETQHIVGRMIDLAPACRGNIEEIMEDP WIRSIDMCHLVEDGLSFKVVRGEDHHHTQVDQSEAHIAGLEKKKKKQNNQ" gene complement(295960..297627) /gene="IPI3" /locus_tag="YNL182C" mRNA complement(295960..297627) /gene="IPI3" /locus_tag="YNL182C" /product="chromatin-binding/pre-rRNA-processing protein IPI3" CDS complement(295960..297627) /gene="IPI3" /locus_tag="YNL182C" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:22421151]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15528184]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:22421151]" /experiment="EXISTENCE:direct assay:GO:0120330 rixosome complex [PMID:14759368]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:15528184]" /experiment="EXISTENCE:mutant phenotype:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:22421151]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:14759368]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:22421151]" /note="Component of the Rix1 complex and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene; other members include Rix1p, Ipi1p, and Ipi3p" /codon_start=1 /product="chromatin-binding/pre-rRNA-processing protein IPI3" /protein_id="DAA10370.1" /db_xref="SGD:S000005126" /translation="MDEQVIFTTNTSGTIASVHSFEQINLRQCSTQSRNSCVQVGNKY LFIAQAQKALINVYNLSGSFKRESVEQRLPLPEILKCLEVVENDGVQYDRIQGVNHNL PDFNLPYLLLGSTESGKLYIWELNSGILLNVKPMAHYQSITKIKSILNGKYIITSGND SRVIIWQTVDLVSASNDDPKPLCILHDHTLPVTDFQVSSSQGKFLSCTDTKLFTVSQD ATIRCYDLSLIGSKKKQKANENDVSIGKTPVLLATFTTPYSIKSIVLDPADRACYIGT AEGCFSLNLFYKLKGNAIVNLLQSAGVNTVQKGRVFSLVQRNSLTGGENEDLDALYAM GQLVCENVLNSNVSCLEISMDGTLLLIGDTEGKVSIAEIYSKQIIRTIQTLTTSQDSV GEVTNLLTNPYRLERGNLLFEGESKGKQPSNNNGHNFMKIPNLQRVIFDGKNKGHLHD IWYQIGEPEAETDPNLALPLNDFNAYLEQVKTQESIFSHIGKVSSNVKVIDNKIDATS SLDSNAAKDEEITELKTNIEALTHAYKELRDMHEKLYEEHQQMLDKQ" gene 298335..299558 /gene="PBR1" /locus_tag="YNL181W" mRNA 298335..299558 /gene="PBR1" /locus_tag="YNL181W" /product="putative oxidoreductase" CDS 298335..299558 /gene="PBR1" /locus_tag="YNL181W" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14690591|PMID:14562095]" /note="Putative oxidoreductase; required for cell viability" /codon_start=1 /product="putative oxidoreductase" /protein_id="DAA10371.2" /db_xref="SGD:S000005125" /translation="MPLNIIGTALLDGTDKIPYYQTIKKVAPYVLATGAIKYWSRGPS NTWERKLHGKVYLVTGATSQGMGTSVAYKMAELGAQLIILTREVDEWVTEWCEELREK TKNELIFVEKCDLSNLWEIRKFATSWLDNSPPRRLDGVIVMSGDMEPWGIPKISLPQR RSSKDGLELQIATNYVAIFHLLNLLQPSFKAQPPDRDVRIILATCWLQVVGDINIEDP LWQNAKYKSALKFFASSKLQLGLSMMELQRRLTEDIKNQKTNGAERTGKNVTITMVQP GTMRSNSLRRVISNGSVVLLIILYCILLYPILWLFTKSGRRGDQSFLYALMTPELEEV NLKDTKVKYISDCSIVKFARKEFDDEELQKKLFDNTERDILQLEKKVAAKRNANKTGN QNSKKKSQNKSRKDD" gene complement(299654..300649) /gene="RHO5" /locus_tag="YNL180C" /gene_synonym="YNS0" mRNA complement(299654..300649) /gene="RHO5" /locus_tag="YNL180C" /gene_synonym="YNS0" /product="Rho family GTPase RHO5" CDS complement(299654..300649) /gene="RHO5" /locus_tag="YNL180C" /gene_synonym="YNS0" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:18216266]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11591390]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:18216266]" /experiment="EXISTENCE:direct assay:GO:0012505 endomembrane system [PMID:18216266]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:18216266]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:18216266]" /note="Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; regulated by phosphorylation and ubiquitination; likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity; necessary for oxidant and ramped heat stress-induced cell death; ortholog of mammalian RAC1" /codon_start=1 /product="Rho family GTPase RHO5" /protein_id="DAA10372.1" /db_xref="SGD:S000005124" /translation="MRSIKCVIIGDGAVGKTSLLISYTTNSFPTDYVPTVFDNYSTTI AIPNGTASSPLELDNGNDKRGSLSSASSSPSTDRKLYKINLWDTAGQEDYDRLRPLCY PQTDIFLICFSVSEHASFANVTEKWLPELKQTSNIEGTSLYTKLGKYPILLVGTKSDL RDDPATQKKLQEANSDYVSQEEIDELVQRCGFMGYTECSAATQAGVREVFEQAVRYAI YEPESPNQKSANHTLTDELTTATTNTNGDKNIREQKQQPHHNNSTDSTLPKGSLQQEK EALNIKPTKKGQKDKIHEQSKSKGSKIASNNHHNKQAKPKTRNDKKKKKSKCVIL" gene 302680..303402 /gene="RPS3" /locus_tag="YNL178W" /gene_synonym="SUF14" mRNA 302680..303402 /gene="RPS3" /locus_tag="YNL178W" /gene_synonym="SUF14" /product="40S ribosomal protein uS3 RPS3" CDS 302680..303402 /gene="RPS3" /locus_tag="YNL178W" /gene_synonym="SUF14" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity [PMID:11561734]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:3533916|PMID:385049|PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:16738661]" /experiment="EXISTENCE:genetic interaction:GO:0000056 ribosomal small subunit export from nucleus [PMID:22570489]" /experiment="EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:28223523]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:28956756]" /experiment="EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:30465652]" /note="Protein component of the small (40S) ribosomal subunit; has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; nascent Rps3p is bound by specific chaperone Yar1p during translation; homologous to mammalian ribosomal protein S3 and bacterial S3" /codon_start=1 /product="40S ribosomal protein uS3 RPS3" /protein_id="DAA10373.1" /db_xref="SGD:S000005122" /translation="MVALISKKRKLVADGVFYAELNEFFTRELAEEGYSGVEVRVTPT KTEVIIRATRTQDVLGENGRRINELTLLVQKRFKYAPGTIVLYAERVQDRGLSAVAQA ESMKFKLLNGLAIRRAAYGVVRYVMESGAKGCEVVVSGKLRAARAKAMKFADGFLIHS GQPVNDFIDTATRHVLMRQGVLGIKVKIMRDPAKSRTGPKALPDAVTIIEPKEEEPIL APSVKDYRPAEETEAQAEPVEA" gene complement(303686..304615) /gene="MRPL22" /locus_tag="YNL177C" /gene_synonym="uL22m" mRNA complement(303686..304615) /gene="MRPL22" /locus_tag="YNL177C" /gene_synonym="uL22m" /product="mitochondrial 54S ribosomal protein YmL22" CDS complement(303686..304615) /gene="MRPL22" /locus_tag="YNL177C" /gene_synonym="uL22m" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit" /codon_start=1 /product="mitochondrial 54S ribosomal protein uL22m MRPL22" /protein_id="DAA10374.2" /db_xref="SGD:S000005121" /translation="MNFHTARISQVGVISRALLSSVSRRWIHVTPISLNNSGGSLFGS ITENKPKEGKNRGDEDAGSFSNRLAIASDSSGEAPEVNRDSITIENDKLLQQHIISLQ QPEQLASQSLLSPLKREIYEANCKINGGFYKKDTIVKLPNSSERYKLKLTKREIEVLE PSVYAQSYRIKSSMKKATLLLRLLGGLDVMKAISQCHFSNKKIAREVAELLQKGVKDG QKLGLKPEDLYISQIWTGSDGFWRKRVEFKARTRIGIISHPYIHVRCILRTKSVTKRR LAYEAHLKEQKRAPWVQLGDKPIRGVTGGVYKW" gene complement(305070..306980) /gene="TDA7" /locus_tag="YNL176C" mRNA complement(305070..306980) /gene="TDA7" /locus_tag="YNL176C" /product="Tda7p" CDS complement(305070..306980) /gene="TDA7" /locus_tag="YNL176C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:23708375|PMID:14562095]" /note="Cell cycle-regulated gene of unknown function; promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele; TDA7 has a paralog, YDL211C, that arose from the whole genome duplication" /codon_start=1 /product="Tda7p" /protein_id="DAA10375.2" /db_xref="SGD:S000005120" /translation="MNSNSTIGRTTLGESDTISLSFSEPSSSLNSRSTDVVFASTSTL VPQQGSLTSLPPVSSTATPTYYSTSLTYDETLHTSIDVSSTSTLVSSTDSSSSSEQDT YSSQYDPATSSYSIITPSMSIFSSTSPMSSSSSITSEWSSLTSTTPTLSSSATSLSSS WSSLSSPSSLLVSSSLSLSLSSSYSDTKLFSFDSRSSIFSPSTPTVISPSYTYLSSIS ATSFQISTTSELSSSWFSTISSPSTISNKDTTFPSSSRNTSTSFYSSSLSSTNDFSTI SKSSKLSPSASSSTVSISTISVPTSSSVSSSSSKVPSNRPSSSSSSDDTTSAYSSTYT FQSLQSTTSSSIPPTTQTPSTSTISTSPIPTSSQVFNTVAISSSEDSKTIYYFYTQTY DITDSSTTFVTGLPTTIAVAKSEVTSFSAPSSTITADMSFYQHWLDGSLDNNKNQGTS KTNTGTIVGSVVGSVGGILICVLVVWFMLVRKRKAKRHFKENDSFCHEIGRRTGFPTT AQAKEASLQAQDSGSQQRNTETASANNPFSNEFNFKARGNPPPVPPPRNVTAMNGSFQ NMRSNFMDQENRFSYGSSFTYSSLGSSTQGGFSTLSSNSIRLGRGLDNDISHDERNTV QNNSQGFLREII" gene complement(307401..308612) /gene="NOP13" /locus_tag="YNL175C" mRNA complement(307401..308612) /gene="NOP13" /locus_tag="YNL175C" /product="Nop13p" CDS complement(307401..308612) /gene="NOP13" /locus_tag="YNL175C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22842922|PMID:11452019]" /experiment="EXISTENCE:direct assay:GO:0030684 preribosome [PMID:17922018]" /note="Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress" /codon_start=1 /product="Nop13p" /protein_id="DAA10376.2" /db_xref="SGD:S000005119" /translation="MSETELSKEDAVTKKDNEEQVKKALLDPTKKRKAEDEIEIDLKS SIPLSKKQKRLLRRGKVTLEELNAKYNIDPKSIEEYKEDAEKKKSGASEKDAQGEEST INTPTGDESGEVVKKKKKDENKYGVWIGNLSFDTTKDDLVRFFIAKTKDNEDEKSRVT EQDITRLSMPRVAAKNSNAMKNKGFCYMFFKNVEQMKAVLELSESHLNGRNMLIKDSE NYSGRPDKDDLVAMSKNPPSRILFVGNLSFDVTDDLLRKHFQHCGDIVKIRMATFEDS GKCKGFAFIDFKNEEGSTNALKDKSCRKIAGRPLRMEYGEDRSKRQVRKKVENVSRNN SSSFDISNNKGYDRAGQDNGSKPEYKRSNANRRPPVDSNNRTKSSVALATAQRGSAAI VPSQGKKVKFD" gene complement(308957..310057) /gene="MDG1" /locus_tag="YNL173C" mRNA complement(308957..310057) /gene="MDG1" /locus_tag="YNL173C" /product="Mdg1p" CDS complement(308957..310057) /gene="MDG1" /locus_tag="YNL173C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8914522|PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:8914522]" /note="Plasma membrane protein; involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations; MDG1 has a paralog, CRP1, that arose from the whole genome duplication" /codon_start=1 /product="Mdg1p" /protein_id="DAA10377.1" /db_xref="SGD:S000005117" /translation="MQSSLPQFTFKWPKGPEAIILTGTFDDWKGTLPMVKDPSGAFEI TLPVTFDSPSSKFYFKFIVDGQWLPSKDYKVNIDEGVENNFITEEDVIKQRENGSSTL VPESAGLAVSKNAPLIEPEAEKRAKKLRKFKIKRVIKTNKQTGERSIFSQEVVELPDS EDETQQVNKTGKNADGLSGTTTIIENNVGVNEEKAIKPYEENHPKVNLVKSEGYVTDG LGKTQSSESRLYELSAEDLEKEEEEEDEDKGGGKDTSTSADAEASEDQNKEPLSKSAK FEKPEEKVPVSSITSHAKETSVKPTGKVATETQTYETKQGAPTAAAKKIEAKKATRPS KPKGTKETPNKGVQKNPAKNGGFFKKLAQLLK" gene 310636..315882 /gene="APC1" /locus_tag="YNL172W" mRNA 310636..315882 /gene="APC1" /locus_tag="YNL172W" /product="anaphase promoting complex subunit 1" CDS 310636..315882 /gene="APC1" /locus_tag="YNL172W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]" /experiment="EXISTENCE:direct assay:GO:0060090 molecular adaptor activity [PMID:16481473]" /experiment="EXISTENCE:mutant phenotype:GO:0007091 metaphase/anaphase transition of mitotic cell cycle [PMID:8895471]" /experiment="EXISTENCE:mutant phenotype:GO:0010458 exit from mitosis [PMID:8895471]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16481473]" /experiment="EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:16481473|PMID:8895471]" /experiment="EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:16481473]" /note="Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress" /codon_start=1 /product="anaphase promoting complex subunit 1" /protein_id="DAA10378.2" /db_xref="SGD:S000005116" /translation="MTSKPSTRNDYLPRETHNGEYTGDSPEWQLQINITNKIGGINGD IWLSRDGRSVKWCIEDQCLRQFTYNQKIIKAGYIDFEKTPDCFVVVLSDIAHVYMLKN GGSTTVCFPFQIGNAFWYANGVILERETSASFMDGGYDLKPIEFDLKHKYITLTDPMA PFGLISITNTFKGGINSASGNKTDILQDFQLVLFPSDKDKCIAVFLDRNSKVLRFYYS RILSSDQSRKGELTISSTKKTGLDAAGNSQKSGGISKDLRKFSHLTRRSTSINSNSHD FNAAERVLSGNVGNASGRTDIFALPSSCSRRSLSATLDRMGNNIAPTNRAAPSGFFDS SSANTATHSNITPVSQPMQQQQQEYLNQTATSSKDIVLTEISSLKLPDDIIFTSRRLS SILSKLKFLSLRFERREGLLIFHEPTHFCKIWLIDLLPDVLDSIPFKIYGNSPQNMIR LENLKLKEPSRIQAMYIHELLESCLILVSEGQNKEEYKACLYDPFVKITSPSKNISEE LTKQNSLPSLQKLFPYPETSFTKLCFEAVKYITSPAFNISFIFLWQSAYSILLSRAND DVVGGLKMEHDAFSLVLSLLILPIPSSSAQEYQEYKEIYERDLFQHLKQDSEITSSVL PRIVIGLHLIREEYSLNVLCRNEHALLGQFLRFATAAMGWPDLWQSYYVPKMDSESKT FLHPREQNSTFFHPLDEPPSITKSLYSITENSSIPLCPFISFSRLVATDTQVELRITP RSFKILGLYELVHSPNFLPDYVLGILSSFKVDKDELQTYPLGILVPLQNILKILEDKL SEVRDNLELLDRADLQRCSAIINSIRSDSKEVLKRGQRDSYMLCKVPLAKNRSSLSKK PSDIYSILSEIVKSASQVPLDGSAMRMSNIQDDEDIDEGRSLKLNAGLIFSEDKRFTH VVSLLAYYRPTKTQFFTTKTEYAQILAQKKYFAKIMALRTCTNGVGWGAVAYATEKPI STQKWVIQPLNLISVFPDDTKITVKAPEDIAHDIVEWGQFHAGVSSGLRISKKATGIT GSWIAFNKPKELDAYHGGFLLGLGLNGHLKNLEEWHIYNYLSPRNTHISIGLLLGMSS SMKGSMDSKLIKVISVHLVAFLPSGSSDLNIDLKLQTAGIIGMGMLYLNSRHKRMSDS IFAQLVSLLNVNDEMVADEEYRLAAGISLGLINLGAGQTKLRKWDSSLLGLGDDLPED VYDSSDVEQNVMYEDLTTKLLEIVTSTYDVENDWIPENSQIGAVIAIMFLFLKSNNFG ISNMLKVDLKEILKANINTRPELLMYREWASNMILWEFIGDDLSFIMKDVDIGVKFSE LNTDLLPIYYTMAGRILAMGIRFASTGNLKIRNILLSLVDKFLPLYQYPGKQNLDFRL TISVINVLTNVIVVSLSMVMCASGDLEVLRRVKYLHEVASGPYSDLFQEIPSSKSDVS GVTQVTSNTNTPGNSDRERVDETAASLDDERSSNGSDISDPTAYLEDKKDIDDHYGKF ISTNLALGFLFLGSGQYALNTSTLESIAFLSMSVLPTYTTPHPLQELKHFWSMAVEPR CLVIKDISTGDAVNNVPIELVVEEDVEKEEVIREISTPCLLPDFSKIKSIRVKMHGYF PLEVNFTKDYSASDFFSGGTIIYIQRKSESVFENKASFRNVEDIHVALKRKAAESKNY SRLNLKNEQGNTTSSQLVESLGIQDLTMVELDTLLSAGNNTALTDSESYNLGLLCSDK NSGDILDCQLELWYKSFGPHDE" gene complement(316169..317671) /gene="PSD1" /locus_tag="YNL169C" mRNA complement(316169..317671) /gene="PSD1" /locus_tag="YNL169C" /product="phosphatidylserine decarboxylase 1" CDS complement(316169..317671) /gene="PSD1" /locus_tag="YNL169C" /EC_number="4.1.1.65" /experiment="EXISTENCE:direct assay:GO:0004609 phosphatidylserine decarboxylase activity [PMID:23124206]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:23124206]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:34818062]" /experiment="EXISTENCE:direct assay:GO:0006656 phosphatidylcholine biosynthetic process [PMID:6427211]" /experiment="EXISTENCE:direct assay:GO:0016540 protein autoprocessing [PMID:25829489]" /experiment="EXISTENCE:direct assay:GO:0140042 lipid droplet formation [PMID:34818062]" /experiment="EXISTENCE:mutant phenotype:GO:0004609 phosphatidylserine decarboxylase activity [PMID:8407984]" /experiment="EXISTENCE:mutant phenotype:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:30926815]" /experiment="EXISTENCE:mutant phenotype:GO:0010636 positive regulation of mitochondrial fusion [PMID:23045528]" /experiment="EXISTENCE:mutant phenotype:GO:0010954 positive regulation of protein processing [PMID:23045528]" /note="Phosphatidylserine decarboxylase of the mitochondrial inner membrane; converts phosphatidylserine to phosphatidylethanolamine; regulates mitochondrial fusion and morphology; partly exposed to the mitochondrial intermembrane space; ER-localized fraction is involved in formation of lipid droplets; autocatalytically processed" /codon_start=1 /product="phosphatidylserine decarboxylase 1" /protein_id="DAA10379.1" /db_xref="SGD:S000005113" /translation="MSIMPVKNALAQGRTLLMGRMPAVKFSTRMQLRNRTAVLWNRKF STRLFVQQRRSSGEIVDRAKAAAANSGRKQVSMKWVVLTSFTIVLGTILLVSRNDSTE EDATEGKKGRRTRKIKIFNNNWLFFCYSTLPLNAMSRLWGQVNSLTLPIWVRPWGYRL YSFLFGVNLDEMEDPDLTHYANLSEFFYRNIKPGTRPVAQGEDVIASPSDGKILQVGI INSETGEIEQVKGMTYSIKEFLGTHSHPLMSKSASSLDLTSDEEKHREFARVNRIQLA GSEDTEQPLLNFKNEGDQSVREFKPSVSKNIHLLSQLSLNYFSNGFSCSEPHDTELFF AVIYLAPGDYHHFHSPVDWVCKVRRHFPGDLFSVAPYFQRNFPNLFVLNERVALLGSW KYGFFSMTPVGATNVGSIKLNFDQEFVTNSKSDKHLEPHTCYQAVYENASKILGGMPL VKGEEMGGFELGSTVVLCFEAPTEFKFDVRVGDKVKMGQKLGIIGKNDLK" gene complement(318030..318809) /gene="FMP41" /locus_tag="YNL168C" mRNA complement(318030..318809) /gene="FMP41" /locus_tag="YNL168C" /product="Fmp41p" CDS complement(318030..318809) /gene="FMP41" /locus_tag="YNL168C" /EC_number="5.3.2.2" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:14576278|PMID:16823961]" /note="hypothetical protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /codon_start=1 /product="Fmp41p" /protein_id="DAA10380.1" /db_xref="SGD:S000005112" /translation="MSYNYLKAARKIICIGRNYAAHIKELNNSTPKQPFFFLKPTSSI VTPLSSSLVKTTRPANSTFNGLNEDGTNPGPIFIPRGVKVHHEIELALIVSKHLSNVT KMKPEEVYDSISGVALALDLTARNVQDEAKKKGLPWTISKGFDTFMPISAIVSREKFS SYKSNLQDIFRVKCSVNGQLRQDGGTNLMLHPLHKILQHISTMISLEPGDIILTGTPA GVGELKPGDRVHCELLQNNDNIVDMNFECENRPGPYEFRET" gene complement(319416..321359) /gene="SKO1" /locus_tag="YNL167C" /gene_synonym="ACR1" mRNA complement(319416..321359) /gene="SKO1" /locus_tag="YNL167C" /gene_synonym="ACR1" /product="Sko1p" CDS complement(319416..321359) /gene="SKO1" /locus_tag="YNL167C" /gene_synonym="ACR1" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:11113177|PMID:11500510|PMID:12086627|PMID:1437546|PM ID:9858577|PMID:1448073]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:1448073|PMID:1437546|PMID:9858577|PMID:11113177]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:12086627]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11500510]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11500510]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12086627]" /experiment="EXISTENCE:direct assay:GO:0051019 mitogen-activated protein kinase binding [PMID:11230135]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11230135|PMID:11500510]" /experiment="EXISTENCE:direct assay:GO:0071470 cellular response to osmotic stress [PMID:12086627]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9858577]" /experiment="EXISTENCE:genetic interaction:GO:0003714 transcription corepressor activity [PMID:11230135]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11230135|PMID:11113177]" /experiment="EXISTENCE:genetic interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11230135]" /experiment="EXISTENCE:genetic interaction:GO:0071470 cellular response to osmotic stress [PMID:11113177|PMID:11230135]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11230135|PMID:11113177|PMID:9858577|PMID:1448073|PMI D:1437546|PMID:10825197]" /experiment="EXISTENCE:mutant phenotype:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:11113177]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:12086627]" /experiment="EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:9858577|PMID:11113177|PMID:1448073|PMID:1437546]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:12086627]" /experiment="EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:11230135]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11230135|PMID:12086627|PMID:11113177|PMID:10825197]" /experiment="EXISTENCE:mutant phenotype:GO:0051019 mitogen-activated protein kinase binding [PMID:12086627]" /experiment="EXISTENCE:mutant phenotype:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11230135]" /experiment="EXISTENCE:mutant phenotype:GO:0071470 cellular response to osmotic stress [PMID:12086627|PMID:11230135|PMID:11113177|PMID:10825197]" /note="Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses" /codon_start=1 /product="Sko1p" /protein_id="DAA10381.1" /db_xref="SGD:S000005111" /translation="MSSEERSRQPSTVSTFDLEPNPFEQSFASSKKALSLPGTISHPS LPKELSRNNSTSTITQHSQRSTHSLNSIPEENGNSTVTDNSNHNDVKKDSPSFLPGQQ RPTIISPPILTPGGSKRLPPLLLSPSILYQANSTTNPSQNSHSVSVSNSNPSAIGVSS TSGSLYPNSSSPSGTSLIRQPRNSNVTTSNSGNGFPTNDSQMPGFLLNLSKSGLTPNE SNIRTGLTPGILTQSYNYPVLPSINKNTITGSKNVNKSVTVNGSIENHPHVNIMHPTV NGTPLTPGLSSLLNLPSTGVLANPVFKSTPTTNTTDGTVNNSISNSNFSPNTSTKAAV KMDNPAEFNAIEHSAHNHKENENLTTQIENNDQFNNKTRKRKRRMSSTSSTSKASRKN SISRKNSAVTTAPAQKDDVENNKISNNVTLDENEEQERKRKEFLERNRVAASKFRKRK KEYIKKIENDLQFYESEYDDLTQVIGKLCGIIPSSSSNSQFNVNVSTPSSSSPPSTSL IALLESSISRSDYSSAMSVLSNMKQLICETNFYRRGGKNPRDDMDGQEDSFNKDTNVV KSENAGYPSVNSRPIILDKKYSLNSGANISKSNTTTNNVGNSAQNIINSCYSVTNPLV INANSDTHDTNKHDVLSTLPHNN" rep_origin 321921..322213 /note="ARS1415; Autonomously Replicating Sequence" /db_xref="SGD:S000118385" gene complement(322219..323565) /gene="BNI5" /locus_tag="YNL166C" mRNA complement(322219..323565) /gene="BNI5" /locus_tag="YNL166C" /product="Bni5p" CDS complement(322219..323565) /gene="BNI5" /locus_tag="YNL166C" /experiment="EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:12215547]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922|PMID:12215547]" /experiment="EXISTENCE:genetic interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:25971666]" /experiment="EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:12215547]" /experiment="EXISTENCE:mutant phenotype:GO:0072741 protein localization to cell division site [PMID:21173112]" /experiment="EXISTENCE:physical interaction:GO:0032035 myosin II tail binding [PMID:21173112]" /note="Linker protein responsible for recruitment of myosin to the bud neck; interacts with the C-terminal extensions of septins Cdc11p and Shs1p and binds Myo1p to promote cytokinesis" /codon_start=1 /product="Bni5p" /protein_id="DAA10382.1" /db_xref="SGD:S000005110" /translation="MGLDQDKIKKRLSQIEIDINQMNQMIDENLQLVEPAEDEAVEDN VKDTGVVDAVKVAETALFSGNDGADSNPGDSAQVEEHKTAQVHIPTENEANKSTDDPS QLSVTQPFIAKEQITHTAIAIGDSYNSFVANSAGNEKAKDSCTENKEDGTVNIDQNRG EADVEIIENNDDEWEDEKSDVEEGRVDKGTEENSEIESFKSPMPQNNTLGGENKLDAE LVLDKFSSANKDLDIQPQTIVVGGDNEYNHESSRLADQTPHDDNSENCPNRSGGSTPL DSQTKIFIPKKNSKEDGTNINHFNSDGDGQKKMANFETRRPTNPFRVISVSSNSNSRN GSRKSSLNKYDSPVSSPITSASELGSIAKLEKRHDYLSMKCIKLQKEIDYLNKMNAQG SLSMEDGKRLHRAVVKLQEYLDKKTKEKYEVGVLLSRHLRKQIDRGENGQFWIGTK" gene 323832..325052 /locus_tag="YNL165W" mRNA 323832..325052 /locus_tag="YNL165W" /product="hypothetical protein" CDS 323832..325052 /locus_tag="YNL165W" /note="hypothetical protein; YNL165W is not an essential gene" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10383.1" /db_xref="SGD:S000005109" /translation="MDRVRSLIGNRRGRRHNRQHPPYPHSGSPSTVNLLGANGYGDDQ STIFARENESLETSANEGDDSADAATLNTAVSEGSTIGDLQRQGYVNRAPRFTSERAM PFVSVLLQRGFFAFPSEESLQLFLHNKRKLDNIDPKRGLGLPLFHAISLNLVKSLFSD QNTPVMRIYKYVMIDSQCDKPPLNSEVVSRINENVSIYKYEFCTILKKMESHNFSSRV EHDFIFHRKDEPDVHIPMINYNQRKNADTAIHGLNLRWYGTTSLASPFGSNSINLLVL DDTMASYMNQQTIEEFDSYSRSRPTRPLGYLPVWARYTDDKVSVIPKKRTLRVATLYL QETDSFDDGSSLTSTNYTEMGSNIIENVPWDSQILTCMCMLLHEYESRKEKRHTAWGS STTYMLNGPAGLLM" rep_origin 325054..325267 /note="ARS1416; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay" /db_xref="SGD:S000130142" gene complement(325265..326320) /gene="IBD2" /locus_tag="YNL164C" mRNA complement(325265..326320) /gene="IBD2" /locus_tag="YNL164C" /product="Ibd2p" CDS complement(325265..326320) /gene="IBD2" /locus_tag="YNL164C" /experiment="EXISTENCE:genetic interaction:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:12072457]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:12072457]" /note="Component of the BUB2-dependent spindle checkpoint pathway; interacts with Bfa1p and functions upstream of Bub2p and Bfa1p" /codon_start=1 /product="Ibd2p" /protein_id="DAA10384.1" /db_xref="SGD:S000005108" /translation="MTPTNQSSGTTNASVEVLSEDGPMPINVMMQEGVKALTKILSNQ LQDRQAFQNAPHAMQFVIRNGGKALSNARLEELKDALPKMDSLSLEDELAKIDGQSAY HIDSAEEKETFESKIGQIASRNSADFIIEEDLQNILDDDLKDSELNLDGEEAEIIFDY ESQELDTPDGIGEKISQMIESVLPGGFGSEEQGGLRTVTNVEDLDVAEEVTDIDHDTV DAARLHGDGQHSISSRKHSRSKNSKKNGHVRRHDFYDESRDHKSCCPHHHYENLSKLR NYYYHDFEYISRTENRVPDFSVLVNESSPMCLFCEYYMVFGEPPRNMIKWYNRTFGYN RMPNPPRDEQDSRKRNR" gene complement(326741..330073) /gene="RIA1" /locus_tag="YNL163C" /gene_synonym="EFL1" mRNA complement(326741..330073) /gene="RIA1" /locus_tag="YNL163C" /gene_synonym="EFL1" /product="GTPase RIA1" CDS complement(326741..330073) /gene="RIA1" /locus_tag="YNL163C" /gene_synonym="EFL1" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11779510]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11779510]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0042256 cytosolic ribosome assembly [PMID:11779510]" /note="Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, a guanine nucleotide exchange factor (GEF), promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes" /codon_start=1 /product="GTPase RIA1" /protein_id="DAA10385.1" /db_xref="SGD:S000005107" /translation="MPRVESETYKRLQNDPSCIRNICIVAHVDHGKTSLSDSLLASNG IISQRLAGKIRFLDARPDEQLRGITMESSAISLYFRVLRKQEGSDEPLVSEHLVNLID SPGHIDFSSEVSAASRLCDGAVVLVDVVEGVCSQTVTVLRQCWTEKLKPILVLNKIDR LITELQLTPQEAYIHLSKVIEQVNSVIGSFFANERQLDDLFWREQLEKNENAEYIEKD DSGIYFNPTDNNVIFASAIDGWGFNIGQLAKFYEQKLGAKRENLQKVLWGDFYMDPKT KKIINNKGLKGRSLKPLFTSLILENIWKIYQNIITSRDSEMVEKIAKTLNIKLLARDL RSKDDKQLLRTIMGQWLPVSTAVLLTVIEKLPSPLESQTDRLNTILVSESDTAAMDPR LLKAMKTCDKEGPVSAYVSKMLSIPREELPVESKRIASSDELMERSRKAREEALNAAK HAGMVENMAMMDLNDNSKNTSDLYKRAKDTVMTPEVGEQTKPKPSRNNDVFCVVSEPS SALDLEFEYEGEDDSDSQDNFGLDFVPTDIDPNDPLSSMFEYEEEDPLLESIKQISED VNDEVDDIFDEKEECLVAFARIYSGTLRVGQEISVLGPKYDPKCPEEHIETAIITHLY LFMGKELVPLDVCPSGNIVGIRGLAGKVLKSGTLIEKGVQGVNLAGVNFHFTPIVRVA VEPANPVEMSKLVRGLKLLDQADPCVHTYVENTGEHILCTAGELHLERCLKDLTERFA GIEITHSEPAIPYRETFLSASDMNPPQNSQLGRGVHELLLSQYKITFRTFPLSGKVTD FLSQHQNSIKNILKTSTSSMDPVIESTGSSFLDKKSLLVAFEEVINQEEKSRELLSGF KVKLAGFGPSRVGCNILLSQDNLLGSLFEGTPAAFEYSDSIKNGFQLAVSEGPLANEP VQGMCVLVESVHKMSQDEIESIEDPRYQQHIVDLSGRLITSTRDAIHEAFLDWSPRIM WAIYSCDIQTSVDVLGKVYAVILQRHGKIISEEMKEGTPFFQIEAHVPVVEAFGLSED IRKRTSGAAQPQLVFSGFECIDLDPFWVPTTEEELEELGDTADRENIARKHMNAIRRR KGLFIEEKVVENAEKQRTLKKN" gene 330329..330547 /locus_tag="YNL162W-A" mRNA 330329..330547 /locus_tag="YNL162W-A" /product="hypothetical protein" CDS 330329..330547 /locus_tag="YNL162W-A" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; identified by homology" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10386.1" /db_xref="SGD:S000007624" /translation="MSDKPDSQVFCPNCNERLQKCLVQQNYAIIICPSLVCGYPFNQR EVLENLTYVDDNDVLKVAKKRLSSRSKP" gene 331322..332154 /gene="RPL42A" /locus_tag="YNL162W" mRNA join(331322..331325,331838..332154) /gene="RPL42A" /locus_tag="YNL162W" /product="60S ribosomal protein eL42 RPL42A" CDS join(331322..331325,331838..332154) /gene="RPL42A" /locus_tag="YNL162W" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L42A; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42A has a paralog, RPL42B, that arose from the whole genome duplication" /codon_start=1 /product="60S ribosomal protein eL42 RPL42A" /protein_id="DAA10387.1" /db_xref="SGD:S000005106" /translation="MVNVPKTRKTYCKGKTCRKHTQHKVTQYKAGKASLFAQGKRRYD RKQSGFGGQTKPVFHKKAKTTKKVVLRLECVKCKTRAQLTLKRCKHFELGGEKKQKGQ ALQF" gene 332597..334867 /gene="CBK1" /locus_tag="YNL161W" mRNA 332597..334867 /gene="CBK1" /locus_tag="YNL161W" /product="serine/threonine protein kinase CBK1" CDS 332597..334867 /gene="CBK1" /locus_tag="YNL161W" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:10970846]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:18715118]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11747810|PMID:12196508]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10970846|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:12196508]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:10970846|PMID:11747810|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922|PMID:12196508|PMID:11747810|PMID:10970846|P MID:11259593]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:10970846]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:11747810|PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:12972564|PMID:11259593]" /experiment="EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:19962308]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:12196508|PMID:11747810]" /experiment="EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:11259593|PMID:12972564]" /experiment="EXISTENCE:mutant phenotype:GO:0007163 establishment or maintenance of cell polarity [PMID:12196508]" /experiment="EXISTENCE:mutant phenotype:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:11259593]" /experiment="EXISTENCE:mutant phenotype:GO:0050708 regulation of protein secretion [PMID:30455324]" /note="Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress" /codon_start=1 /product="serine/threonine protein kinase CBK1" /protein_id="DAA10388.1" /db_xref="SGD:S000005105" /translation="MYNSSTNHHEGAPTSGHGYYMSQQQDQQHQQQQQYANEMNPYQQ IPRPPAAGFSSNYMKEQGSHQSLQEHLQRETGNLGSGFTDVPALNYPATPPPHNNYAA SNQMINTPPPSMGGLYRHNNNSQSMVQNGNGSGNAQLPQLSPGQYSIESEYNQNLNGS SSSSPFHQPQTLRSNGSYSSGLRSVKSFQRLQQEQENVQVQQQLSQAQQQNSRQQQQQ LQYQQQQQQQQQQQHMQIQQQQQQQQQQQQSQSPVQSGFNNGTISNYMYFERRPDLLT KGTQDKAAAVKLKIENFYQSSVKYAIERNERRVELETELTSHNWSEERKSRQLSSLGK KESQFLRLRRTRLSLEDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKD QLAHVKAERDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTED VTRFYMAECILAIETIHKLGFIHRDIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNY YKKLLQQDEATNGISKPGTYNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRL MAYSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIM NFEQTLQFPDDIHISYEAEDLIRRLLTHADQRLGRHGGADEIKSHPFFRGVDWNTIRQ VEAPYIPKLSSITDTRFFPTDELENVPDSPAMAQAAKQREQMTKQGGSAPVKEDLPFI GYTYSRFDYLTRKNAL" gene 336545..337609 /gene="YGP1" /locus_tag="YNL160W" mRNA 336545..337609 /gene="YGP1" /locus_tag="YNL160W" /product="Ygp1p" CDS 336545..337609 /gene="YGP1" /locus_tag="YNL160W" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:19129178]" /experiment="EXISTENCE:direct assay:GO:0070726 cell wall assembly [PMID:10234784]" /note="Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; protein demonstrates amyloid properties in vivo; YGP1 has a paralog, SPS100, that arose from the whole genome duplication" /codon_start=1 /product="Ygp1p" /protein_id="DAA10389.1" /db_xref="SGD:S000005104" /translation="MKFQVVLSALLACSSAVVASPIENLFKYRAVKASHSKNINSTLP AWNGSNSSNVTYANGTNSTTNTTTAESSQLQIIVTGGQVPITNSSLTHTNYTRLFNSS SALNITELYNVARVVNETIQDKSSAGAVVVANAKSLEAVSFFFSIIFDTEKPIVVTED SAYAIPVANNKNATKRGVLSVTSDKLVYSGVFTPPTACSYGAGLPVAIVDDQDEVKWF FDASKPTLISSDSIIRKEYSNFTTPYGLLENGVPIVPIVYDGGYSSSLIDSLSSAVQG LVVVSSGSTNSTSSTIESTEIPVVYAQANTPLNFIDNKDVPKNAVGAGYLSPIKAQIL LSIAAVNGVTSKSALESIFP" gene complement(338478..339347) /gene="ASI2" /locus_tag="YNL159C" mRNA complement(338478..339347) /gene="ASI2" /locus_tag="YNL159C" /product="Asi2p" CDS complement(338478..339347) /gene="ASI2" /locus_tag="YNL159C" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:17085444]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0097658 Asi complex [PMID:25236469]" /experiment="EXISTENCE:genetic interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:11454748]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:25236469]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:25253722]" /experiment="EXISTENCE:mutant phenotype:GO:0071230 cellular response to amino acid stimulus [PMID:17085444]" /note="Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; the Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and inner for ubiquitin-mediated degradation; acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids" /codon_start=1 /product="Asi2p" /protein_id="DAA10390.1" /db_xref="SGD:S000005103" /translation="MARPQNHRRSNWTERDDNDDYLFQRFLEESETRHSREPSPVTEQ SQQELQQDVQQAIDGIFNSLRRNMSSTSNINRAANMDATTNGNGGINADTIRATNANT ADSPFTARQQSPLRTFLRNLFILDYFIGLILFPFSVYNILRSGFNSMTFSENDFIIEI VGYWKFAKIFGSGGTTLIAYKDTGKLGLLGKFHNIIVFYSSPVIKHIMKSRDGNEPNL NWIRLMFAKAFELFVKVSTILIYLAYGVSGTVYMVTAGFFFVLCLLFTVIRRYKGVHR MLVSQRITGPGVF" gene 339612..340208 /gene="PGA1" /locus_tag="YNL158W" mRNA 339612..340208 /gene="PGA1" /locus_tag="YNL158W" /product="Pga1p" CDS 339612..340208 /gene="PGA1" /locus_tag="YNL158W" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:17615295]" /experiment="EXISTENCE:genetic interaction:GO:0000030 mannosyltransferase activity [PMID:17615295]" /experiment="EXISTENCE:genetic interaction:GO:0031501 mannosyltransferase complex [PMID:17615295]" /experiment="EXISTENCE:mutant phenotype:GO:0000030 mannosyltransferase activity [PMID:17615295]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:17615295]" /experiment="EXISTENCE:physical interaction:GO:0031501 mannosyltransferase complex [PMID:17615295]" /note="Essential component of GPI-mannosyltransferase II; complex is responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interactions with secretory pathway genes" /codon_start=1 /product="Pga1p" /protein_id="DAA10391.1" /db_xref="SGD:S000005102" /translation="MVRPQNVHWFIATIVFFIGFVHANTESILYKVPHNFPLKKPRDS STYARDVNLISSISLSGEAMSQITIEANTTDLELHNTTYIELADLQRDETYQIKVCWS AIHPISINNLQTITIPRFTEFQGTKSDYARILVTFQVLSDSYPSEHAMVPIQVSLITT RLGIPVDIYPTLIVMVLLVAGLVVTRAPHVLNDLLLKF" gene 340352..340858 /gene="IGO1" /locus_tag="YNL157W" mRNA 340352..340858 /gene="IGO1" /locus_tag="YNL157W" /product="phosphatase regulator" CDS 340352..340858 /gene="IGO1" /locus_tag="YNL157W" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:20471941]" /experiment="EXISTENCE:direct assay:GO:0004865 protein serine/threonine phosphatase inhibitor activity [PMID:23273919|PMID:23861665]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:20471941]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0034605 cellular response to heat [PMID:23861665]" /experiment="EXISTENCE:genetic interaction:GO:0048255 mRNA stabilization [PMID:20471941]" /experiment="EXISTENCE:genetic interaction:GO:1900152 negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:20471941]" /experiment="EXISTENCE:genetic interaction:GO:1901992 positive regulation of mitotic cell cycle phase transition [PMID:23861665]" /experiment="EXISTENCE:genetic interaction:GO:1903452 positive regulation of G1 to G0 transition [PMID:23273919|PMID:20471941]" /experiment="EXISTENCE:mutant phenotype:GO:0004865 protein serine/threonine phosphatase inhibitor activity [PMID:23273919]" /note="Protein required for initiation of the G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylation (S63) by Rim15p increases interaction with and inhibition of PP2A-Cdc55 for timely mitotic progression; can also activate PP2A-Cdc55 complexes and influence Cdc55p localization along with Igo2p; GFP protein localizes to the cytoplasm and nucleus; IGO1 has a paralog, IGO2, that arose from the whole genome duplication" /codon_start=1 /product="phosphatase regulator" /protein_id="DAA10392.1" /db_xref="SGD:S000005101" /translation="MSNENLSPNSSNPDLTKLNNGESGTIDTSKFSPNEMKLYKMYGK LPSKKDIFKHTMQKRKYFDSGDYALQKAGIQNNDPINYGKNNLPLTNPSKLREDIIKR RISTCPSTASTAGVVDNATLIQKEGSISSGPPSSNNGTIGGGSTSSTPVGNHSSSSSS LYTESPIR" gene complement(341069..341968) /gene="NSG2" /locus_tag="YNL156C" mRNA complement(341069..341968) /gene="NSG2" /locus_tag="YNL156C" /product="Nsg2p" CDS complement(341069..341968) /gene="NSG2" /locus_tag="YNL156C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0016126 sterol biosynthetic process [PMID:16270032]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:16270032]" /note="Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; NSG2 has a paralog, NSG1, that arose from the whole genome duplication" /codon_start=1 /product="Nsg2p" /protein_id="DAA10393.1" /db_xref="SGD:S000005100" /translation="MANRGEPDPKKSTESICSLTKPQLYSLYDDDVVRSEDNEIYEEL KRSVSIDSTKYSRDQTIDSTFYLAHKVGGSLPRNTVSSNNLERILSASSIHENFPSRT RQTRQNILHYLQAVLILSLSGFAYHELSRNLHDNHLLHPDFASRPLLLGVKLCNWLSN GVLPNWLGYGVEGLLFGSVVPILDNIFQTEVVKSSVHHDSLTSVIRSINAMLGVTFGI RKIQWNSSLQAAGAWGLLNIILWLFFDGSISMLMSCICIGVGCCISCYKDIIDGSQFL YFMDFYFLGSLMFGKLGRYLYSH" gene complement(341911..342135) /locus_tag="YNL155C-A" mRNA complement(341911..342135) /locus_tag="YNL155C-A" /product="hypothetical protein" CDS complement(341911..342135) /locus_tag="YNL155C-A" /note="hypothetical protein; well conserved across Saccharomyces species; added to genome annotation based on proteomic, translation, and evolutionary evidence" /codon_start=1 /product="hypothetical protein" /protein_id="DBA54442.1" /db_xref="SGD:S000350099" /translation="MIGLIVVPILFAIKGIVVGVQKVKKKFGKHSNTKDQKEDKDEDK RQSISQRKQHTEWPIEENRIQRRAPNQSAL" gene 342516..343340 /gene="CUZ1" /locus_tag="YNL155W" mRNA 342516..343340 /gene="CUZ1" /locus_tag="YNL155W" /product="Cuz1p" CDS 342516..343340 /gene="CUZ1" /locus_tag="YNL155W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0070628 proteasome binding [PMID:24121501|PMID:24297164]" /experiment="EXISTENCE:genetic interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:24121501]" /experiment="EXISTENCE:genetic interaction:GO:0071243 cellular response to arsenic-containing substance [PMID:24297164]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:24121501]" /experiment="EXISTENCE:mutant phenotype:GO:0071243 cellular response to arsenic-containing substance [PMID:24297164]" /experiment="EXISTENCE:physical interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:24121501]" /note="Protein involved in Ub-proteasome dependent catabolism; interacts with Cdc48p and the proteasome, protecting cells from arsenite-induced proteotoxicity through stress granule (SG) clearance; contains a PACE promoter element; co-regulated with proteasome subunit genes; contains an AN1-type zinc finger, a DHHC domain and a UBL fold; complements SG clearance in arsenite treated HeLa cells depleted of ZFAND1, a human ortholog linked to cancer; protein abundance increases under DNA replication stress" /codon_start=1 /product="Cuz1p" /protein_id="DAA10394.1" /db_xref="SGD:S000005099" /translation="MSAAIEKETGMLDVGKHCAYCRQLDFLPFHCSFCNEDFCSNHRL KEDHHCRWLLEHEEVHKTEKSPSKSRDGSSSNDEAYFKSLLPERASVRIQRVSETREP LRGSNTAKVSSTLNSKTLDKIFKFFQRNEKRKSNNKSKKNFGSSSNKIIQLANLKKIA KGDPKIPMQNRIYIWCYLVDGDETDIAKEDTRMPLYINKMWPVGRAMDYLSIQLNVKS STLTNSSSNDKFQLCKLKEGKQVSFYNIGASLRVTNEIKDLDTLYLVHNNADEKSN" gene complement(343636..345276) /gene="YCK2" /locus_tag="YNL154C" mRNA complement(343636..345276) /gene="YCK2" /locus_tag="YNL154C" /product="serine/threonine protein kinase YCK2" CDS complement(343636..345276) /gene="YCK2" /locus_tag="YNL154C" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:8474447]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8034689|PMID:1627830|PMID:12469340|PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10198058]" /experiment="EXISTENCE:direct assay:GO:0005937 mating projection [PMID:10198058]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0000902 cell morphogenesis [PMID:8474447]" /experiment="EXISTENCE:genetic interaction:GO:0010255 glucose mediated signaling pathway [PMID:27630263]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:10198058]" /experiment="EXISTENCE:mutant phenotype:GO:0009749 response to glucose [PMID:14755054]" /note="Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; involved in the phosphorylation and regulation of glucose sensor Rgt2p; YCK2 has a paralog, YCK1, that arose from the whole genome duplication" /codon_start=1 /product="serine/threonine protein kinase YCK2" /protein_id="DAA10395.1" /db_xref="SGD:S000005098" /translation="MSQVQSPLTATNSGLAVNNNTMNSQMPNRSNVRLVNGTLPPSLH VSSNLNHNTGNSSASYSGSQSRDDSTIVGLHYKIGKKIGEGSFGVLFEGTNMINGLPV AIKFEPRKTEAPQLKDEYRTYKILAGTPGIPQEYYFGQEGLHNILVIDLLGPSLEDLF DWCGRRFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANKVHLID FGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDMEAMGHVFFYFL RGQLPWQGLKAPNNKQKYEKIGEKKRLTNVYDLAQGLPIQFGRYLEIVRNLSFEETPD YEGYRMLLLSVLDDLGETADGQYDWMKLNGGRGWDLSINKKPNLHGYGHPNPPNEKSK RHRSKNHQYSSPDHHHHYNQQQQQQQAQAQAQAQAQAKVQQQQLQQAQAQQQANRYQL QPDDSHYDEEREASKLDPTSYEAYQQQTQQKYAQQQQKQMQQKSKQFANTGANGQTNK YPYNAQPTANDEQNAKNAAQDRNSNKSSKGFFSKLGCC" gene complement(345669..346058) /gene="GIM3" /locus_tag="YNL153C" /gene_synonym="PFD4" mRNA complement(345669..346058) /gene="GIM3" /locus_tag="YNL153C" /gene_synonym="PFD4" /product="tubulin-binding prefolding complex subunit GIM3" CDS complement(345669..346058) /gene="GIM3" /locus_tag="YNL153C" /gene_synonym="PFD4" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9463374]" /experiment="EXISTENCE:direct assay:GO:0015631 tubulin binding [PMID:9463374]" /experiment="EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]" /experiment="EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:9463374]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]" /experiment="EXISTENCE:mutant phenotype:GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system [PMID:27448207]" /experiment="EXISTENCE:physical interaction:GO:0016272 prefoldin complex [PMID:9463374]" /note="Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation" /codon_start=1 /product="tubulin-binding prefolding complex subunit GIM3" /protein_id="DAA10396.1" /db_xref="SGD:S000005097" /translation="MELLPQGQRNNTQVTFEDQQKINEFSKLIMRKDAIAQELSLQRE EKEYLDDVSLEIELIDEDEPVQYKVGDLFIFMKQSKVTAQLEKDAERLDNKIETLEDK QRDIDSRLDALKAILYAKFGDNINLER" gene 346313..347542 /gene="INN1" /locus_tag="YNL152W" mRNA 346313..347542 /gene="INN1" /locus_tag="YNL152W" /product="Inn1p" CDS 346313..347542 /gene="INN1" /locus_tag="YNL152W" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:18344988]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:genetic interaction:GO:0030234 enzyme regulator activity [PMID:22956544]" /experiment="EXISTENCE:genetic interaction:GO:1990344 secondary cell septum biogenesis [PMID:19528296]" /experiment="EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:22956544|PMID:18344988]" /experiment="EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:18439903]" /experiment="EXISTENCE:mutant phenotype:GO:1990344 secondary cell septum biogenesis [PMID:19528296]" /experiment="EXISTENCE:physical interaction:GO:0044697 HICS complex [PMID:22623719]" /note="Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis" /codon_start=1 /product="Inn1p" /protein_id="DAA10397.1" /db_xref="SGD:S000005096" /translation="MSEEVWNGNQGILSVYVSKARDLPNLNKLDKQNVMLRLRIAHMT RASNTLHRAGQNPVFHYLEKFDITPEIKPLMYVEVYCDRRKKSPLPIGRCEIDLLNAI RADPKEGYCTWYELKRSGDEFAGTIFIELTFTPKVPRLNRDDLNKEMDRLDSSMAMRP IPPLPTESEYDYVHGSTMRQITPQCVSTSHEDKDEGQPYRNGNVFSMSSKSDTAVLAN SNDPIILPPTFSASMGTTSTLETNDTAISNTSNTKFHFANLRKLKEKINIFKNPDSST NNCQNESNKVDIEALQKAIGVTSLSYDEDDDDDDENDAFYSSSHRVSHNYNQPPLPPI PTRDDMSNYSSSRNTPLVRRDRPSRLDSSSPNSHPHPSGLNSPKLPPLPTTSNSNFNS RKNSMSPTRKRPPPRLS" gene complement(347766..348521) /gene="RPC31" /locus_tag="YNL151C" /gene_synonym="ACP2" /gene_synonym="RPC8" mRNA complement(347766..348521) /gene="RPC31" /locus_tag="YNL151C" /gene_synonym="ACP2" /gene_synonym="RPC8" /product="DNA-directed RNA polymerase III subunit C31" CDS complement(347766..348521) /gene="RPC31" /locus_tag="YNL151C" /gene_synonym="ACP2" /gene_synonym="RPC8" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:3905793|PMID:10611227]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:mutant phenotype:GO:0006384 transcription initiation at RNA polymerase III promoter [PMID:7835345]" /experiment="EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:2201900]" /note="RNA polymerase III subunit C31" /codon_start=1 /product="DNA-directed RNA polymerase III subunit C31" /protein_id="DAA10398.1" /db_xref="SGD:S000005095" /translation="MSSYRGGSRGGGSNYMSNLPFGLGYGDVGKNHITEFPSIPLPIN GPITNKERSLAVKYINFGKTVKDGPFYTGSMSLIIDQQENSKSGKRKPNIILDEDDTN DGIERYSDKYLKKRKIGISIDDHPYNLNLFPNELYNVMGINKKKLLAISKFNNADDVF TGTGLQDENIGLSMLAKLKELAEDVDDASTGDGAAKGSKTGEGEDDDLADDDFEEDED EEDDDDYNAEKYFNNGDDDDYGDEEDPNEEAAF" gene complement(349367..349756) /gene="PGA2" /locus_tag="YNL149C" mRNA complement(349367..349756) /gene="PGA2" /locus_tag="YNL149C" /product="Pga2p" CDS complement(349367..349756) /gene="PGA2" /locus_tag="YNL149C" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762|PMID:14690591]" /experiment="EXISTENCE:mutant phenotype:GO:0015031 protein transport [PMID:16943325]" /note="Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect" /codon_start=1 /product="Pga2p" /protein_id="DAA10399.1" /db_xref="SGD:S000005093" /translation="MSEVAETWVDTWMAKLVNYDYKHFIRLVIIVGGYLLLRNIASRE LAKKQLAAQVEKDKRDKEEKRSKDLIDKPDDAATAETTSFGWGKKTRRRVKRQQELFE NALEEAKRRNQGLDPDSDADIEELLEE" gene complement(349907..350671) /gene="ALF1" /locus_tag="YNL148C" mRNA complement(349907..350671) /gene="ALF1" /locus_tag="YNL148C" /product="Alf1p" CDS complement(349907..350671) /gene="ALF1" /locus_tag="YNL148C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0007023 post-chaperonin tubulin folding pathway [PMID:9885248]" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:9885248]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:9885248]" /experiment="EXISTENCE:mutant phenotype:GO:0007023 post-chaperonin tubulin folding pathway [PMID:9885248]" /experiment="EXISTENCE:physical interaction:GO:0043014 alpha-tubulin binding [PMID:9885248]" /note="Alpha-tubulin folding protein; similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance" /codon_start=1 /product="Alf1p" /protein_id="DAA10400.1" /db_xref="SGD:S000005092" /translation="MVRVVIESELVRTEKELPNSLKLRQFKDRLYHVTGVEPEDMEIV VKRQYDNKEIYSTKKGGAYSNEDEDANFLKGEEELIVVVTDSNAQSISNQLATQAEGI PSMEVISEEDYLRRDQSVLRWKMAHGYGRFNAAQQSQRAALAKQDEAYAREQLTAAIG RHCRVTVDGSAPREAILRYVGPLPLDVMGTWCGVEFPEAAGKNDGRINGVTLFGPVAP GHGSFVRPRAVEILSKDEESAEVEDVHDDVESDDEI" gene 350940..351383 /gene="LSM7" /locus_tag="YNL147W" mRNA join(350940..350957,351054..351383) /gene="LSM7" /locus_tag="YNL147W" /product="Sm-like protein LSM7" CDS join(350940..350957,351054..351383) /gene="LSM7" /locus_tag="YNL147W" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:10369684]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005688 U6 snRNP [PMID:10369684|PMID:10747033|PMID:11720284]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:18029398|PMID:15075370]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:18029398]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419]" /experiment="EXISTENCE:direct assay:GO:1990726 Lsm1-7-Pat1 complex [PMID:24139796]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:10428970|PMID:11333229]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:10747033]" /experiment="EXISTENCE:mutant phenotype:GO:0030490 maturation of SSU-rRNA [PMID:19806183]" /experiment="EXISTENCE:physical interaction:GO:0005732 sno(s)RNA-containing ribonucleoprotein complex [PMID:15075370]" /note="Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress" /codon_start=1 /product="Sm-like protein LSM7" /protein_id="DAA10401.1" /db_xref="SGD:S000005091" /translation="MHQQHSKSENKPQQQRKKFEGPKREAILDLAKYKDSKIRVKLMG GKLVIGVLKGYDQLMNLVLDDTVEYMSNPDDENNTELISKNARKLGLTVIRGTILVSL SSAEGSDVLYMQK" gene complement(351386..351580) /locus_tag="YNL146C-A" mRNA complement(351386..351580) /locus_tag="YNL146C-A" /product="hypothetical protein" CDS complement(351386..351580) /locus_tag="YNL146C-A" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10402.1" /db_xref="SGD:S000028851" /translation="MISVCFVFPHSLALDFKSRCKKNRTKLCSAYYVSQVLRICKEMP YRDLILFSTVRKGVYMRLYY" gene 351715..352017 /locus_tag="YNL146W" mRNA 351715..352017 /locus_tag="YNL146W" /product="hypothetical protein" CDS 351715..352017 /locus_tag="YNL146W" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10403.1" /db_xref="SGD:S000005090" /translation="MSNTKHTTSHHMELKRIIILTLLFILIMLIFRNSVSFKMTFQEL LPRFYKKNSNSVSNNNRPSSIFSENLVDFDDVNMVDKTRLFIFLFFSFIITIPFMV" gene 352414..352530 /gene="MFA2" /locus_tag="YNL145W" mRNA 352414..352530 /gene="MFA2" /locus_tag="YNL145W" /product="mating pheromone a" CDS 352414..352530 /gene="MFA2" /locus_tag="YNL145W" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:2046670]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:3285180]" /experiment="EXISTENCE:mutant phenotype:GO:0000772 mating pheromone activity [PMID:3285180]" /note="Mating pheromone a-factor; made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1" /codon_start=1 /product="mating pheromone a" /protein_id="DAA10404.1" /db_xref="SGD:S000005089" /translation="MQPITTASTQATQKDKSSEKKDNYIIKGLFWDPACVIA" gene complement(352820..355042) /gene="MPF1" /locus_tag="YNL144C" mRNA complement(352820..355042) /gene="MPF1" /locus_tag="YNL144C" /product="Mpf1p" CDS complement(352820..355042) /gene="MPF1" /locus_tag="YNL144C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0032473 cytoplasmic side of mitochondrial outer membrane [PMID:40175596]" /note="hypothetical protein; involved in the dual distribution of tail-anchored proteins such as Fis1p and Gem1p to mitochondria and peroxisomes; unstable protein that associates with the cytosolic face of the mitochondrial outer membrane; detected in highly purified mitochondria in high-throughput studies; contains a PH domain that impacts protein stability; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study" /codon_start=1 /product="Mpf1p" /protein_id="DAA10405.1" /db_xref="SGD:S000005088" /translation="MSSSIFEMTIDHDGMDSTGLKLSQTASSISMGDEFLCSSTTSNS ILDSPLPKVTFNHIDSITDINTNIMNEIVEPQSGVDVDVADKNVLYCIDPYPVEPPCY DFANPSKVIRYPIYEHCRPCLTSVKPPSYTPSVEHYTVVSMKMEKLSPFENASSRLWN NFILQINSTQINFYSIDDSLTRHIKNYRGGDMFDHSHHSKTASDRHHSARSLLNAFTT KSTYQFDKYDKERICGEIARDEHKFLSDERLFKSYSLQCAKVGLPIDYSSRDFVLRMR CEGQQFLVQFSHVDELIYWAMYLNMGISLSLDLELREMPTYRSVPRRRHPRARRFKQH NKNKNKNKSRQNSDRNDSRSHSLLLRRSHTSSVVTKVATGNERPTNKSRSRSLSLLPP SVSDASHDSNGPNDSGSLAGESSQTDFCGLFTSKLRNFFKTDSSSRKNSNMDIGQKMR SKELNSVQEEIDDNGSTTNTNTSVLSSTFSPTAHSVLTAQTSIHENFRSRSNSNPIDP LRCDRSVLKINNFEPVYEGTGRSTISNSAERTNREEKLNRGNEDVNGDEDDDEDEDDA NYEEDDEDGYVEDDDINRLVYLDERESRYENADVEYGTIFSTKSFSVTGCLNHDFPKK LSLKCGNKNQSSNDSKWAPATQLVSRKRYIKDSLRCIKPLTEDHPWVGKIIFKPALPP AFETNNPPIRVYSGEDSTDLMHVKNHYLKPYIVGSCGFLKTGSKLFHFYDRTNDLTNL " gene complement(356794..357186) /locus_tag="YNL143C" mRNA complement(356794..357186) /locus_tag="YNL143C" /product="hypothetical protein" CDS complement(356794..357186) /locus_tag="YNL143C" /note="hypothetical protein; expressed at both mRNA and protein levels" /codon_start=1 /product="hypothetical protein" /protein_id="DAA35133.1" /db_xref="SGD:S000005087" /translation="MREQLKLFTREIVDFTFLILSGFDYYQTLLISSNSSKKRPKDSS LLSEKKKKKKKKKKDVLSYLSYLKDLPFVPFLFWQPGYSQREKNPRQHSLFIMTITKP GMISMADMNYVVSKNRSLNRPAERGGNR" gene 357453..358952 /gene="MEP2" /locus_tag="YNL142W" mRNA 357453..358952 /gene="MEP2" /locus_tag="YNL142W" /product="ammonium permease MEP2" CDS 357453..358952 /gene="MEP2" /locus_tag="YNL142W" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11069679|PMID:24124599]" /experiment="EXISTENCE:direct assay:GO:0008519 ammonium channel activity [PMID:9234685]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9482721]" /experiment="EXISTENCE:mutant phenotype:GO:0008519 ammonium channel activity [PMID:9234685]" /experiment="EXISTENCE:mutant phenotype:GO:0019740 nitrogen utilization [PMID:9234685]" /experiment="EXISTENCE:mutant phenotype:GO:0072488 ammonium transmembrane transport [PMID:9234685]" /experiment="EXISTENCE:mutant phenotype:GO:1900430 positive regulation of filamentous growth of a population of unicellular organisms [PMID:32069286]" /note="Ammonium permease involved in regulation of pseudohyphal growth; belongs to Mep-Amt-Rh family of well-conserved ammonium (NH4+) transporters that includes human Rh factors; expression is under nitrogen catabolite repression regulation; activity is controlled by phospho-silencing; phosphorylation of Mep2 mediated by Npr1; dephosphorylation involves Psr1p and Psr2p; Twin-His motif ensures transport specificity" /codon_start=1 /product="ammonium permease MEP2" /protein_id="DAA10406.1" /db_xref="SGD:S000005086" /translation="MSYNFTGTPTGEGTGGNSLTTDLNTQFDLANMGWIGVASAGVWI MVPGIGLLYSGLSRKKHALSLLWASMMASAVCIFQWFFWGYSLAFSHNTRGNGFIGTL EFFGFRNVLGAPSSVSSLPDILFAVYQGMFAAVTGALMLGGACERARLFPMMVFLFLW MTIVYCPIACWVWNAEGWLVKLGSLDYAGGLCVHLTSGHGGLVYALILGKRNDPVTRK GMPKYKPHSVTSVVLGTVFLWFGWMFFNGGSAGNATIRAWYSIMSTNLAAACGGLTWM VIDYFRCGRKWTTVGLCSGIIAGLVGITPAAGFVPIWSAVVIGVVTGAGCNLAVDLKS LLRIDDGLDCYSIHGVGGCIGSVLTGIFAADYVNATAGSYISPIDGGWINHHYKQVGY QLAGICAALAWTVTVTSILLLTMNAIPFLKLRLSADEEELGTDAAQIGEFTYEESTAY IPEPIRSKTSAQMPPPHENIDDKIVGNTDAEKNSTPSDASSTKNTDHIV" gene 359596..360639 /gene="AAH1" /locus_tag="YNL141W" mRNA 359596..360639 /gene="AAH1" /locus_tag="YNL141W" /product="adenine deaminase" CDS 359596..360639 /gene="AAH1" /locus_tag="YNL141W" /EC_number="3.5.4.2" /experiment="EXISTENCE:direct assay:GO:0000034 adenine deaminase activity [PMID:1577682]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006146 adenine catabolic process [PMID:1577682]" /experiment="EXISTENCE:direct assay:GO:0043101 purine-containing compound salvage [PMID:1577682]" /experiment="EXISTENCE:direct assay:GO:0043103 hypoxanthine salvage [PMID:1577682]" /experiment="EXISTENCE:mutant phenotype:GO:0000034 adenine deaminase activity [PMID:1577682]" /experiment="EXISTENCE:mutant phenotype:GO:0006146 adenine catabolic process [PMID:1577682]" /experiment="EXISTENCE:mutant phenotype:GO:0043101 purine-containing compound salvage [PMID:1577682]" /experiment="EXISTENCE:mutant phenotype:GO:0043103 hypoxanthine salvage [PMID:1577682]" /note="Adenine deaminase (adenine aminohydrolase); converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome" /codon_start=1 /product="adenine deaminase" /protein_id="DAA10407.1" /db_xref="SGD:S000005085" /translation="MVSVEFLQELPKCEHHLHLEGTLEPDLLFPLAKRNDIILPEGFP KSVEELNEKYKKFRDLQDFLDYYYIGTNVLISEQDFFDLAWAYFKKVHKQGLVHAEVF YDPQSHTSRGISIETVTKGFQRACDKAFSEFGITSKLIMCLLRHIEPEECLKTIEEAT PFIKDGTISALGLDSAEKPFPPHLFVECYGKAASLNKDLKLTAHAGEEGPAQFVSDAL DLLQVTRIDHGINSQYDEELLDRLSRDQTMLTICPLSNVKLQVVQSVSELPLQKFLDR DVPFSLNSDDPAYFGGYILDVYTQVSKDFPHWDHETWGRIAKNAIKGSWCDDKRKNGL LSRVDEVVTKYSH" gene complement(360917..361486) /locus_tag="YNL140C" mRNA complement(360917..361486) /locus_tag="YNL140C" /product="hypothetical protein" CDS complement(360917..361486) /locus_tag="YNL140C" /note="hypothetical protein; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C" /codon_start=1 /product="hypothetical protein" /protein_id="DAA35134.1" /db_xref="SGD:S000005084" /translation="MLEAKMVMVVPTIEDQAMIVLHPKILSQSVVMHIKGQNYQLDLV KVKHIMIEVGHLDPQVRTGAMVLIKGITAYVKSIRKTVHNVHNYGFLKSHFKRAKTAA KPTLTKLHLTSATRLQKMKKSRIKDSRRMKQLETNFKRKIIEIHEIAVLPIEPMKIKG TTEIERAILRRFRKVPRVGITSVGTRGNY" gene complement(360924..365717) /gene="THO2" /locus_tag="YNL139C" /gene_synonym="LDB5" /gene_synonym="RLR1" /gene_synonym="ZRG13" mRNA complement(360924..365717) /gene="THO2" /locus_tag="YNL139C" /gene_synonym="LDB5" /gene_synonym="RLR1" /gene_synonym="ZRG13" /product="Tho2p" CDS complement(360924..365717) /gene="THO2" /locus_tag="YNL139C" /gene_synonym="LDB5" /gene_synonym="RLR1" /gene_synonym="ZRG13" /experiment="EXISTENCE:direct assay:GO:0000445 THO complex part of transcription export complex [PMID:11979277]" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:24084588]" /experiment="EXISTENCE:direct assay:GO:0003676 nucleic acid binding [PMID:12093753]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:11139493]" /experiment="EXISTENCE:mutant phenotype:GO:0000446 nucleoplasmic THO complex [PMID:11060033]" /experiment="EXISTENCE:mutant phenotype:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:17537816]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:11060033]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:12093753|PMID:17960421]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:11979277]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:18614048]" /experiment="EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:27251550]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:26663077]" /experiment="EXISTENCE:mutant phenotype:GO:0097185 cellular response to azide [PMID:27251550]" /experiment="EXISTENCE:mutant phenotype:GO:2001209 positive regulation of transcription elongation by RNA polymerase I [PMID:26663077]" /note="Subunit of the THO complex; THO is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids" /codon_start=1 /product="Tho2p" /protein_id="DAA10408.1" /db_xref="SGD:S000005083" /translation="MAEQTLLSKLNALSQKVIPPASPSQASILTEEVIRNWPERSKTL CSDFTALESNDEKEDWLRTLFIELFDFINKNDENSPLKLSDVASFTNELVNHERQVSQ ASIVGKMFIAVSSTVPNINDLTTISLCKLIPSLHEELFKFSWISSKLLNKEQTTLLRH LLKKSKYELKKYNLLVENSVGYGQLVALLILAYYDPDNFSKVSAYLKEIYHIMGKYSL DSIRTLDVILNVSSQFITEGYKFFIALLRKSDSWPSSHVANNSNYSSLNEGGNMIAAN IISFNLSQYNEEVDKENYERYMDMCCILLKNGFVNFYSIWDNVKPEMEFLQEYIQNLE TELEEESTKGVENPLAMAAALSTENETDEDNALVVNDDVNMKDKISEETNADIESKGK QKTQQDILLFGKIKLLERLLIHGCVIPVIHVLKQYPKVLYVSESLSRYLGRVFEYLLN PLYTSMTSSGESKDMATALMITRIDNGILAHKPRLIHKYKTHEPFESLELNSSYVFYY SEWNSNLTPFASVNDLFENSHIYLSIIGPYLGRIPTLLSKISRIGVADIQKNHGSESL HVTIDKWIDYVRKFIFPATSLLQNNPIATSEVYELMKFFPFEKRYFIYNEMMTKLSQD ILPLKVSFNKAEREAKSILKALSIDTIAKESRRFAKLISTNPLASLVPAVKQIENYDK VSELVVYTTKYFNDFAYDVLQFVLLLRLTYNRPAVQFDGVNQAMWVQRLSIFIAGLAK NCPNMDISNIITYILKTLHNGNIIAVSILKELIITVGGIRDLNEVNMKQLLMLNSGSP LKQYARHLIYDFRDDNSVISSRLTSFFTDQSAISEIILLLYTLNLKANTQNSHYKILS TRCDEMNTLLWSFIELIKHCLKGKAFEENVLPFVELNNRFHLSTPWTFHIWRDYLDNQ LNSNENFSIDELIEGAEFSDVDLTKISKDLFTTFWRLSLYDIHFDKSLYDERKNALSG ENTGHMSNRKKHLIQNQIKDILVTGISHQRAFKKTSEFISEKSNVWNKDCGEDQIKIF LQNCVVPRVLFSPSDALFSSFFIFMAFRTENLMSILNTCITSNILKTLLFCCTSSEAG NLGLFFTDVLKKLEKMRLNGDFNDQASRKLYEWHSVITEQVIDLLSEKNYMSIRNGIE FMKHVTSVFPVVKAHIQLVYTTLEENLINEEREDIKLPSSALIGHLKARLKDALELDE FCTLTEEEAEQKRIREMELEEIKNYETACQNEQKQVALRKQLELNKSQRLQNDPPKSV ASGSAGLNSKDRYTYSRNEPVIPTKPSSSQWSYSKVTRHVDDINHYLATNHLQKAISL VENDDETRNLRKLSKQNMPIFDFRNSTLEIFERYFRTLIQNPQNPDFAEKIDSLKRYI KNISREPYPDTTSSYSEAAAPEYTKRSSRYSGNAGGKDGYGSSNYRGPSNDRSAPKNI KPISSYAHKRSELPTRPSKSKTYNDRSRALRPTGPDRGDGFDQRDNRLREEYKKNSSQ RSQLRFPEKPFQEGKDSSKANPYQASSYKRDSPSENEEKPNKRFKKDETIRNKFQTQD YRNTRDSGAAHRANENQRYNGNRKSNTQALPQGPKGGNYVSRYQR" gene 366033..366412 /gene="YSF3" /locus_tag="YNL138W-A" /gene_synonym="RCP10" mRNA join(366033..366035,366158..366412) /gene="YSF3" /locus_tag="YNL138W-A" /gene_synonym="RCP10" /product="U2 snRNP complex subunit YSF3" CDS join(366033..366035,366158..366412) /gene="YSF3" /locus_tag="YNL138W-A" /gene_synonym="RCP10" /experiment="EXISTENCE:direct assay:GO:0005686 U2 snRNP [PMID:16314500|PMID:15565172]" /experiment="EXISTENCE:mutant phenotype:GO:0000245 spliceosomal complex assembly [PMID:16314500]" /note="Component of the SF3b subcomplex of the U2 snRNP; essential protein required for splicing and for assembly of SF3b" /codon_start=1 /product="U2 snRNP complex subunit YSF3" /protein_id="DAA10409.1" /db_xref="SGD:S000028509" /translation="MAEKQRQLKLQKIYKQKYIGLGDESTTREQWQRNVRNDTLNTLQ GHSASLEYVSLSRGDLSIRDTRIHLLKSMSPGYKAYLREER" gene 366741..368321 /gene="SRV2" /locus_tag="YNL138W" /gene_synonym="CAP" mRNA 366741..368321 /gene="SRV2" /locus_tag="YNL138W" /gene_synonym="CAP" /product="adenylate cyclase-binding protein" CDS 366741..368321 /gene="SRV2" /locus_tag="YNL138W" /gene_synonym="CAP" /experiment="EXISTENCE:direct assay:GO:0003779 actin binding [PMID:19201756]" /experiment="EXISTENCE:direct assay:GO:0007015 actin filament organization [PMID:19201756]" /experiment="EXISTENCE:direct assay:GO:0008179 adenylate cyclase binding [PMID:2184942]" /experiment="EXISTENCE:direct assay:GO:0030042 actin filament depolymerization [PMID:26458246]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:8552082]" /experiment="EXISTENCE:direct assay:GO:0030836 positive regulation of actin filament depolymerization [PMID:26458246]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0051014 actin filament severing [PMID:23135996]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:19201756]" /experiment="EXISTENCE:mutant phenotype:GO:0007265 Ras protein signal transduction [PMID:9774417]" /experiment="EXISTENCE:mutant phenotype:GO:0030833 regulation of actin filament polymerization [PMID:30639852]" /experiment="EXISTENCE:mutant phenotype:GO:0090141 positive regulation of mitochondrial fission [PMID:30639852]" /note="Cyclase-associated protein, CAP; accelerates nucleotide exchange and actin filament depolymerization; N-terminus binds adenylate cyclase, facilitating activation by RAS and directly catalyzes cofilin-mediated severing of actin filaments; C-terminus binds and recycles cofilin bound, ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis; processively tracks and promotes depolymerization of actin filament barbed and pointed ends; mCAP1 is the mouse homolog" /codon_start=1 /product="adenylate cyclase-binding protein" /protein_id="DAA10410.1" /db_xref="SGD:S000005082" /translation="MPDSKYTMQGYNLVKLLKRLEEATARLEDVTIYQEGYIQNKLEA SKNNKPSDSGADANTTNEPSAENAPEVEQDPKCITAFQSYIGENIDPLVELSGKIDTV VLDALQLLKGGFQSQLTFLRAAVRSRKPDYSSQTFADSLRPINENIIKLGQLKESNRQ SKYFAYLSALSEGAPLFSWVAVDTPVSMVTDFKDAAQFWTNRILKEYRESDPNAVEWV KKFLASFDNLKAYIKEYHTTGVSWKKDGMDFADAMAQSTKNTGATSSPSPASATAAPA PPPPPPAPPASVFEISNDTPATSSDANKGGIGAVFAELNQGENITKGLKKVDKSQQTH KNPELRQSSTVSSTGSKSGPPPRPKKPSTLKTKRPPRKELVGNKWFIENYENETESLV IDANKDESIFIGKCSQVLVQIKGKVNAISLSETESCSVVLDSSISGMDVIKSNKFGIQ VNHSLPQISIDKSDGGNIYLSKESLNTEIYTSCSTAINVNLPIGEDDDYVEFPIPEQM KHSFADGKFKSAVFEHAG" gene complement(368595..370055) /gene="NAM9" /locus_tag="YNL137C" /gene_synonym="MNA6" /gene_synonym="uS4m" mRNA complement(368595..370055) /gene="NAM9" /locus_tag="YNL137C" /gene_synonym="MNA6" /gene_synonym="uS4m" /product="mitochondrial 37S ribosomal protein NAM9" CDS complement(368595..370055) /gene="NAM9" /locus_tag="YNL137C" /gene_synonym="MNA6" /gene_synonym="uS4m" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal component of the small subunit" /codon_start=1 /product="mitochondrial 37S ribosomal protein uS4m NAM9" /protein_id="DAA10411.1" /db_xref="SGD:S000005081" /translation="MPRKANLLKSLARGRVRTSFNKYNLFNLYKKGGVDLKSKSLYQQ KWTAKQETRAYHGEHLTEKRWQTVFKPKLDSVAQLDASLRGGEIKETPFLLQTFAVLE KRLDFALFRAMFASSVRQARQFILHGNVRVNGVKIKHPSYTLKPGDMFSVKPDKVLEA LGAKKPSFQEALKIDKTQIVLWNKYVKEAKTEPKEVWEKKLENFEKMSDSNPKKLQFQ EFLRQYNKNLESQQYNALKGCTQEGILRKLLNVEKEIGKSNNEPLSIDELKQGLPEIQ DSQLLESLNNAYQEFFKSGEIRREIISKCQPDELISLATEMMNPNETTKKELSDGAKS ALRSGKRIIAESVKLWTKNITDHFKTRMSDISDGSLTFDPKWAKNLKYHDPIKLSELE GDEPKARKLINLPWQKNYVYGRQDPKKPFFTPWKPRPFLSPFAILPHHLEISFKTCHA VYLRDPVARPGQSEVISPFDVPVHERAYMYYLRNGK" gene 370368..371645 /gene="EAF7" /locus_tag="YNL136W" mRNA 370368..371645 /gene="EAF7" /locus_tag="YNL136W" /product="Eaf7p" CDS 370368..371645 /gene="EAF7" /locus_tag="YNL136W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15353583]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:15353583]" /experiment="EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:15353583]" /note="Subunit of the NuA4 histone acetyltransferase complex; NuA4 acetylates the N-terminal tails of histones H4 and H2A" /codon_start=1 /product="Eaf7p" /protein_id="DAA10412.1" /db_xref="SGD:S000005080" /translation="MVVHWTIVDEIRLLRWASEFKPAGIHKHFHMFCIVERMNSPDKY PVTLLQKETMKLGKVFTAKDIWDKLSQSYNLEKIDEMENTYSLEATTESSRNGNGNGD DAEIHEETLLELNNRIRVRKQDFTLPWEEYGELILENARKSPNSNEEYPRVEDMNEKD STIPKESPSTDLKNDNNKQEKNATIKVKELPEYHTEENDSPIDVQKEPIKEVQSDEKE LQREHMSEEEQKMKSTNKTAAPVRKSQRLKRSKEVKFEDEEKEEIEEDNTKDEEQKEK KEEIQEPKITHNEEVDKEKNENEEGDDEREKSTSYENTNGSESEGVDEGVDEELGYES EREAEGKGKQIESEGGNLKKKTENKKGDDQQDDTKKDSKDKNEPLAKRTRHSSSTGNT SNETSPKRKRRKAGSRKNSPPATRVSSRLRNKK" gene complement(371882..372226) /gene="FPR1" /locus_tag="YNL135C" /gene_synonym="FKB1" /gene_synonym="RBP1" mRNA complement(371882..372226) /gene="FPR1" /locus_tag="YNL135C" /gene_synonym="FKB1" /gene_synonym="RBP1" /product="peptidylprolyl isomerase FPR1" CDS complement(371882..372226) /gene="FPR1" /locus_tag="YNL135C" /gene_synonym="FKB1" /gene_synonym="RBP1" /EC_number="5.2.1.8" /experiment="EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:1996117]" /experiment="EXISTENCE:direct assay:GO:0005515 protein binding [PMID:36113412]" /experiment="EXISTENCE:direct assay:GO:0005527 macrolide binding [PMID:8325502]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:36113412|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0044183 protein folding chaperone [PMID:34534579]" /experiment="EXISTENCE:direct assay:GO:0070651 nonfunctional rRNA decay [PMID:36113412]" /experiment="EXISTENCE:direct assay:GO:1903332 regulation of protein folding [PMID:34534579]" /experiment="EXISTENCE:genetic interaction:GO:0006325 chromatin organization [PMID:10049913]" /experiment="EXISTENCE:genetic interaction:GO:1901710 regulation of homoserine biosynthetic process [PMID:15470257]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:32603360]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:32603360]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:9362068]" /note="Peptidyl-prolyl cis-trans isomerase (PPIase); binds to FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function; associates with promoters of ribosomal protein genes; acts as chaperone to prevent protein aggregation; N-terminally propionylated in vivo; mutation is functionally complemented by human FKBP1A" /codon_start=1 /product="peptidylprolyl isomerase FPR1" /protein_id="DAA10413.1" /db_xref="SGD:S000005079" /translation="MSEVIEGNVKIDRISPGDGATFPKTGDLVTIHYTGTLENGQKFD SSVDRGSPFQCNIGVGQVIKGWDVGIPKLSVGEKARLTIPGPYAYGPRGFPGLIPPNS TLVFDVELLKVN" gene complement(372451..373581) /locus_tag="YNL134C" mRNA complement(372451..373581) /locus_tag="YNL134C" /product="hypothetical protein" CDS complement(372451..373581) /locus_tag="YNL134C" /experiment="EXISTENCE:direct assay:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:25656244]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:1901426 response to furfural [PMID:25656244]" /note="NADH-dependent aldehyde reductase; involved in detoxification of furfural; expression is up-regulated in the presence of furfural and 5-hydroxymethylfurfural, which are compounds generated during lignocellulosic biomass pre-treatment; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10414.1" /db_xref="SGD:S000005078" /translation="MSASIPETMKAVVIENGKAVVKQDIPIPELEEGFVLIKTVAVAG NPTDWKHIDFKIGPQGALLGCDAAGQIVKLGPNVDAARFAIGDYIYGVIHGASVRFPS NGAFAEYSAISSETAYKPAREFRLCGKDKLPEGPVKSLEGAVSLPVSLTTAGMILTHS FGLDMTWKPSKAQRDQPILFWGGATAVGQMLIQLAKKLNGFSKIIVVASRKHEKLLKE YGADELFDYHDADVIEQIKKKYNNIPYLVDCVSNTETIQQVYKCAADDLDATVVQLTV LTEKDIKEEDRRQNVSIEGTLLYLIGGNDVPFGTFTLPADPEYKEAAIKFIKFINPKI NDGEIHHIPVKVYKNGLDDIPQLLDDIKHGRNSGEKLVAVLK" gene complement(374171..374692) /gene="FYV6" /locus_tag="YNL133C" mRNA complement(374171..374692) /gene="FYV6" /locus_tag="YNL133C" /product="Fyv6p" CDS complement(374171..374692) /gene="FYV6" /locus_tag="YNL133C" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:35705093]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:12399380]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:12399380]" /note="Splicing factor, structural and functional homolog of human FAM192A; plays structural role in intermediate spliceosomal C* complex, which executes exon ligation; required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining" /codon_start=1 /product="Fyv6p" /protein_id="DAA10415.1" /db_xref="SGD:S000005077" /translation="MSSTSDNNANSAREKKPLKFVSEGVGNVEAQRIREQVEQKKYEA EYKRKTRKSLRDQLRSNAISKQKQYNGLVRDRESFTRLSKEDLEFYQKSKNELLKKEK ELNNYLDVKAINFEKKKKALLMENDSTTNTEKYLETGTSLGSKTQIKGVKTSSPKPKI KVSIKKLGRKLEN" gene 374869..374959 /locus_tag="YNCN0006W" tRNA join(374869..374905,374924..374959) /locus_tag="YNCN0006W" /product="tRNA-Phe" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Phenylalanine tRNA (tRNA-Phe), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006569" gene 375321..378491 /gene="KRE33" /locus_tag="YNL132W" /gene_synonym="RRA1" mRNA 375321..378491 /gene="KRE33" /locus_tag="YNL132W" /gene_synonym="RRA1" /product="ribosome biosynthesis protein KRE33" CDS 375321..378491 /gene="KRE33" /locus_tag="YNL132W" /gene_synonym="RRA1" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:28542199]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030515 snoRNA binding [PMID:28542199]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:1990883 18S rRNA cytidine N-acetyltransferase activity [PMID:25086048]" /experiment="EXISTENCE:mutant phenotype:GO:0016556 mRNA modification [PMID:31243956]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:19806183|PMID:12150911]" /note="Acetyltransferase required for biogenesis of small ribosomal subunit; conserved 18S rRNA cytosine acetyltransferase that modifies tRNAs assisted by adaptor Tan1p; responsible for incorporation of N4-acetylcytidine into mRNAs; human homolog NAT10 implicated in several types of cancer and premature aging" /codon_start=1 /product="ribosome biosynthesis protein KRE33" /protein_id="DAA10416.1" /db_xref="SGD:S000005076" /translation="MAKKAIDSRIPSLIRNGVQTKQRSIFVIVGDRARNQLPNLHYLM MSADLKMNKSVLWAYKKKLLGFTSHRKKRENKIKKEIKRGTREVNEMDPFESFISNQN IRYVYYKESEKILGNTYGMCILQDFEALTPNLLARTIETVEGGGIVVILLKSMSSLKQ LYTMTMDVHARYRTEAHGDVVARFNERFILSLGSNPNCLVVDDELNVLPLSGAKNVKP LPPKEDDELPPKQLELQELKESLEDVQPAGSLVSLSKTVNQAHAILSFIDAISEKTLN FTVALTAGRGRGKSAALGISIAAAVSHGYSNIFVTSPSPENLKTLFEFIFKGFDALGY QEHIDYDIIQSTNPDFNKAIVRVDIKRDHRQTIQYIVPQDHQVLGQAELVVIDEAAAI PLPIVKNLLGPYLVFMASTINGYEGTGRSLSLKLIQQLRNQNNTSGRESTQTAVVSRD NKEKDSHLHSQSRQLREISLDEPIRYAPGDPIEKWLNKLLCLDVTLIKNPRFATRGTP HPSQCNLFVVNRDTLFSYHPVSENFLEKMMALYVSSHYKNSPNDLQLMSDAPAHKLFV LLPPIDPKDGGRIPDPLCVIQIALEGEISKESVRNSLSRGQRAGGDLIPWLISQQFQD EEFASLSGARIVRIATNPEYASMGYGSRAIELLRDYFEGKFTDMSEDVRPKDYSIKRV SDKELAKTNLLKDDVKLRDAKTLPPLLLKLSEQPPHYLHYLGVSYGLTQSLHKFWKNN SFVPVYLRQTANDLTGEHTCVMLNVLEGRESNWLVEFAKDFRKRFLSLLSYDFHKFTA VQALSVIESSKKAQDLSDDEKHDNKELTRTHLDDIFSPFDLKRLDSYSNNLLDYHVIG DMIPMLALLYFGDKMGDSVKLSSVQSAILLAIGLQRKNIDTIAKELNLPSNQTIAMFA KIMRKMSQYFRQLLSQSIEETLPNIKDDAIAEMDGEEIKNYNAAEALDQMEEDLEEAG SEAVQAMREKQKELINSLNLDKYAINDNSEEWAESQKSLEIAAKAKGVVSLKTGKKRT TEKAEDIYRQEMKAMKKPRKSKKAAN" gene 378767..379225 /gene="TOM22" /locus_tag="YNL131W" /gene_synonym="MAS17" /gene_synonym="MAS22" /gene_synonym="MOM22" mRNA 378767..379225 /gene="TOM22" /locus_tag="YNL131W" /gene_synonym="MAS17" /gene_synonym="MAS22" /gene_synonym="MOM22" /product="Tom22p" CDS 378767..379225 /gene="TOM22" /locus_tag="YNL131W" /gene_synonym="MAS17" /gene_synonym="MAS22" /gene_synonym="MOM22" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407|PMID:16689936]" /experiment="EXISTENCE:direct assay:GO:0005742 mitochondrial outer membrane translocase complex [PMID:9774667]" /experiment="EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:10519552]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:9774667|PMID:10519552]" /experiment="EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:12628251]" /note="Component of the TOM (Translocase of Outer Membrane) complex; responsible for initial import of mitochondrially directed proteins; mediates interaction between TOM and TIM complexes and acts as receptor for precursor proteins; implicated in mitochondrial accumulation of amyloid beta peptides via direct interaction with amyloid beta peptide residues 25-42 followed by transfer to Tom40p and transport through the TOM channel" /codon_start=1 /product="Tom22p" /protein_id="DAA10417.1" /db_xref="SGD:S000005075" /translation="MVELTEIKDDVVQLDEPQFSRNQAIVEEKASATNNDVVDDEDDS DSDFEDEFDENETLLDRIVALKDIVPPGKRQTISNFFGFTSSFVRNAFTKSGNLAWTL TTTALLLGVPLSLSILAEQQLIEMEKTFDLQSDANNILAQGEKDAAATAN" gene complement(379558..380831) /gene="CPT1" /locus_tag="YNL130C" mRNA complement(join(379558..380689,380782..380831)) /gene="CPT1" /locus_tag="YNL130C" /product="diacylglycerol cholinephosphotransferase" CDS complement(join(379558..380689,380782..380831)) /gene="CPT1" /locus_tag="YNL130C" /EC_number="2.7.8.2" /experiment="EXISTENCE:direct assay:GO:0004142 diacylglycerol cholinephosphotransferase activity [PMID:3029130]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:3005242]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:8543066]" /experiment="EXISTENCE:direct assay:GO:0006657 CDP-choline pathway [PMID:3029130]" /experiment="EXISTENCE:mutant phenotype:GO:0004142 diacylglycerol cholinephosphotransferase activity [PMID:3029130]" /experiment="EXISTENCE:mutant phenotype:GO:0006657 CDP-choline pathway [PMID:3029130]" /note="Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication" /codon_start=1 /product="diacylglycerol cholinephosphotransferase" /protein_id="DAA10418.1" /db_xref="SGD:S000005074" /translation="MGFFIPQSSLGNLKLYKYQSDDRSFLSNHVLRPFWRKFATIFPL WMAPNLVTLLGFCFIIFNVLTTLYYDPYFDQESPRWTYFSYAIGLFLYQTFDACDGMH ARRTGQQGPLGELFDHCIDSINTTLSMIPVCSMTGMGYTYMTIFSQFAILCSFYLSTW EEYHTHKLYLAEFCGPVEGIIVLCISFIAVGIYGPQTIWHTKVAQFSWQDFVFDVETV HLMYAFCTGALIFNIVTAHTNVVRYYESQSTKSATPSKTAENISKAVNGLLPFFAYFS SIFTLVLIQPSFISLALILSIGFSVAFVVGRMIIAHLTMQPFPMVNFPFLIPTIQLVL YAFMVYVLDYQKGSIVSALVWMGLGLTLAIHGMFINDIIYDITTFLDIYALSIKHPKE I" gene complement(381245..381391) /gene="DGR1" /locus_tag="YNL130C-A" mRNA complement(381245..381391) /gene="DGR1" /locus_tag="YNL130C-A" /product="Dgr1p" CDS complement(381245..381391) /gene="DGR1" /locus_tag="YNL130C-A" /note="hypothetical protein; dgr1 null mutant is resistant to 2-deoxy-D-glucose" /codon_start=1 /product="Dgr1p" /protein_id="DAA10419.1" /db_xref="SGD:S000028579" /translation="MQVGFVSQTNCRSFPACIVFLFQMSQRQRSFNANLRVFKSKCKK IYIG" gene 381480..382202 /gene="NRK1" /locus_tag="YNL129W" mRNA 381480..382202 /gene="NRK1" /locus_tag="YNL129W" /product="ribosylnicotinamide kinase" CDS 381480..382202 /gene="NRK1" /locus_tag="YNL129W" /EC_number="2.7.1.22" /EC_number="2.7.1.173" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0046495 nicotinamide riboside metabolic process [PMID:15137942]" /experiment="EXISTENCE:direct assay:GO:0050262 ribosylnicotinamide kinase activity [PMID:15137942]" /experiment="EXISTENCE:genetic interaction:GO:0009435 NAD+ biosynthetic process [PMID:17914902]" /experiment="EXISTENCE:genetic interaction:GO:0034355 NAD+ biosynthetic process via the salvage pathway [PMID:15137942]" /experiment="EXISTENCE:genetic interaction:GO:0046495 nicotinamide riboside metabolic process [PMID:15137942]" /note="Nicotinamide riboside kinase; catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis" /codon_start=1 /product="ribosylnicotinamide kinase" /protein_id="DAA10420.1" /db_xref="SGD:S000005073" /translation="MTSKKVILVALSGCSSSGKTTIAKLTASLFTKATLIHEDDFYKH DNEVPVDAKYNIQNWDSPEALDFKLFGKELDVIKQTGKIATKLIHNNNVDDPFTKFHI DRQVWDELKAKYDSINDDKYEVVIVDGFMIFNNTGISKKFDLKILVRAPYEVLKKRRA SRKGYQTLDSFWVDPPYYFDEFVYESYRANHAQLFVNGDVEGLLDPRKSKNIKEFIND DDTPIAKPLSWVCQEILKLCKD" gene 382359..383663 /gene="TEP1" /locus_tag="YNL128W" mRNA 382359..383663 /gene="TEP1" /locus_tag="YNL128W" /product="putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase" CDS 382359..383663 /gene="TEP1" /locus_tag="YNL128W" /EC_number="3.1.3.67" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15913452]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:11070083]" /note="PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1" /codon_start=1 /product="putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase" /protein_id="DAA10421.1" /db_xref="SGD:S000005072" /translation="MREEGSELEMEKGFLKWKPVNLMKKILSLPMKKTKNDIGLRLDI SYILVNLIVCSYPVNTYPKLLYRNSLDDLILFLTVYHGKGNFRIFNFRGEKEDSDYKD NDLIGIAAKFESKDFEIQELRSTLINDGKIPISPIDLETRTLVEEETNNVICERIGWL DHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGE ARLIFMQARFKYGMTNGVTIPSQLRYLRYHEFFITHEKAAQEGISNEAVKFKFKFRLA KMTFLRPSSLITSESAIVTTKIQHYNDDRNALLTRKVVYSDIMAHECGGNMTFIFGRD YLTLENDCRIEFTLGTSKSKAASSIISWTSCASCWLNIYLETLMHIIKDDSSPDYFQV ERLKRDEMLGTTISWQELDGFGELSTHGLKLFQALKLEWEII" gene 383987..386848 /gene="FAR11" /locus_tag="YNL127W" mRNA 383987..386848 /gene="FAR11" /locus_tag="YNL127W" /product="Far11p" CDS 383987..386848 /gene="FAR11" /locus_tag="YNL127W" /experiment="EXISTENCE:direct assay:GO:0000138 Golgi trans cisterna [PMID:22782902]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:23625923]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:12588993]" /experiment="EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:22782902]" /experiment="EXISTENCE:mutant phenotype:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:22782902]" /note="Protein involved in recovery from cell cycle arrest; acts in response to pheromone; also involved in regulation of intra-S DNA damage checkpoint and autophagy; is essential for dephosphorylation of Atg13p; interacts with Far3p, Far7p, Far8p, Far9p, Far10p and with the phosphatases Pph21p, Pph22p and Pph3p; has similarity to the N- and C-termini of N. crassa HAM-2; similar to human Fam40A and Fam40B" /codon_start=1 /product="Far11p" /protein_id="DAA10422.1" /db_xref="SGD:S000005071" /translation="MNASGRSHSKGPIIRSVSLEDLKRNSSFKGNLKYKDEVTSHKEP QVGTLSNEELLKDLDNMLRGKLNMGRNSFHADKRNKSDGNISALTFKARSGLEGDIRT IDIQQDSSDENDNFKFSDDGVNKDRNNEKDNNTDNAVEFQDDAEEAEEENEDESFANV DELDGFDLNKVSDGKHVPINEKGEVDYNMPVDKEFQKSLDQCAASLEERSSAPYALQR AVDWELKMFYSLEDELSEWFCSSDYMHFGQTQTLFKQKITQPQLFFDDENYAASVVEC LIEDIPNSLASNLLALSYISMGCFAFTNSKSEHTKIIRRNNLMLVPHIQEIVHAFKKI AISCRDDNRNLKKQTILLFHSSTILYFICSICIEGRGENPEAVNVVIDAFEKTDLLEF LTKYIENWRWNSRLAMRIRNMISLLFKLIVLQFGDSSVYKQTKSSIYNLHGLTYPSKH PEKLSISPLHYQAFREDITSRFPDYNMPSSGLPKDVDKSESLSQFLEIPRPKSKNPLN MALIVPEKHIATPAPSPPSSPQLMHLGEGPRPRKSFQTNMAYPCLYPSDNEGSEDDTL EDRIDLNIERKPDNDIVIPFSTEEAARILSESLEIKLSTKQLWYERDLFMITERGWKQ QLENEPYDYAALNHDANSSKEEKSAICIMQRIDKYYKSCLSSFNSLVFVLLQTMESSL TNNFHRKSEVSDKNLLNMLTPQLEIVRAKELSLKSAAGILHALLKWFKLSHILKFEHL AVVIHDSRYINTCASILSKYSEVYPERVFNKYVQTPNSFWKECSLSNESYRESYSVDD SGEVDTEIMPSFAYLLRILRKVTGNKTQRLKELPLSIGILFKRYYRLFNLDMYHPILK ITRELTPFKNKRWKSEHMELISGVYLYEKLELTDNWVTGKDISGELSDACGQEIALRA LLQFYNFQHYEISMEDLGYGHRNSSSQDLLNKESEYLNI" gene 387227..389767 /gene="SPC98" /locus_tag="YNL126W" mRNA 387227..389767 /gene="SPC98" /locus_tag="YNL126W" /product="Spc98p" CDS 387227..389767 /gene="SPC98" /locus_tag="YNL126W" /experiment="EXISTENCE:direct assay:GO:0005822 inner plaque of spindle pole body [PMID:9215630]" /experiment="EXISTENCE:direct assay:GO:0005824 outer plaque of spindle pole body [PMID:9215630]" /experiment="EXISTENCE:direct assay:GO:0007020 microtubule nucleation [PMID:24842996|PMID:11950928]" /experiment="EXISTENCE:direct assay:GO:0008275 gamma-tubulin small complex [PMID:9384578|PMID:9130700|PMID:25599398]" /experiment="EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:9153752]" /experiment="EXISTENCE:mutant phenotype:GO:0043015 gamma-tubulin binding [PMID:8670895]" /experiment="EXISTENCE:physical interaction:GO:0008275 gamma-tubulin small complex [PMID:9130700]" /experiment="EXISTENCE:physical interaction:GO:0043015 gamma-tubulin binding [PMID:8670895|PMID:9130700]" /note="Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque" /codon_start=1 /product="Spc98p" /protein_id="DAA10423.1" /db_xref="SGD:S000005070" /translation="MELEPTLFGIIEALAPQLLSQSHLQTFVSDVVNLLRSSTKSATQ LGPLIDFYKLQSLDSPETTIMWHKIEKFLDALFGIQNTDDMVKYLSVFQSLLPSNYRA KIVQKSSGLNMENLANHEHLLSPVRAPSIYTEASFENMDRFSERRSMVSSPNRYVPSS TYSSVTLRQLSNPYYVNTIPEEDILKYVSYTLLATTSALFPFDHEQIQIPSKIPNFES GLLHLIFEAGLLYQSLGYKVEKFRMLNISPMKKALIIEISEELQNYTAFVNNLVSSGT VVSLKSLYREIYENIIRLRIYCRFTEHLEELSGDTFLIELNIFKSHGDLTIRKIATNL FNSMISLYYEYLMNWLTKGLLRATYGEFFIAENTDTNGTDDDFIYHIPIEFNQERVPA FIPKELAYKIFMIGKSYIFLEKYCKEVQWTNEFSKKYHVLYQSNSYRGISTNFFEIIN DQYSEIVNHTNQILNQKFHYRDVVFALKNILLMGKSDFMDALIEKANDILATPSDSLP NYKLTRVLQEAVQLSSLRHLMNSPRNSSVINGLDARVLDLGHGSVGWDVFTLDYILYP PLSLVLNVNRPFGRKEYLRIFNFLWRFKKNNYFYQKEMLKSNDIIRSFKKIRGYNPLI RDIINKLSRISILRTQFQQFNSKMESYYLNCIIEENFKEMTRKLQRTENKSQNQFDLI RLNNGTIELNGILTPKAEVLTKSSSSKPQKHAIEKTLNIDELESVHNTFLTNILSHKL FATNTSEISVGDYSGQPYPTSLVLLLNSVYEFVKVYCNLNDIGYEIFIKMNLNDHEAS NGLLGKFNTNLKEIVSQYKNFKDRLYIFRADLKNDGDEELFLLSKSLR" gene complement(390146..392167) /gene="ESBP6" /locus_tag="YNL125C" /gene_synonym="MCH3" mRNA complement(390146..392167) /gene="ESBP6" /locus_tag="YNL125C" /gene_synonym="MCH3" /product="Esbp6p" CDS complement(390146..392167) /gene="ESBP6" /locus_tag="YNL125C" /gene_synonym="MCH3" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11536335]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Protein with similarity to monocarboxylate permeases; appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane" /codon_start=1 /product="Esbp6p" /protein_id="DAA10424.1" /db_xref="SGD:S000005069" /translation="MSTHSNDYFSASSGMVSETSSEVSSINSSQPVSFSKASIAAPVP CSDLHSTKSNDASRKLSISRTLTNRLNDIKKAVDDDNLQTEENSADVNKILESRFDVA DAIRLQHNESVQSKLNIPVTHTTTAGASLSAPSSSAFSASSIQNDTTEHKASMDSKLM RNRLYPASTKHSGKDLEAQGITEFEPDEPTVKKVFTNKSTGQLELPPDGGYGWVVTFC VFLTMFSTWGCNASFGVDLAYYLNHDTYPGASKYDYALIAGLTVFLGQLLSPLVMALM RIIGLRTTMLFGDAVMLAAYLLASFTTKLWQLYVTQGFMVGCSISLIFVPATTVLPGW FLKKRAVAMGVSLLGTGAGGVVYGLATNKMLSDFGNTRWCLRIIGISCSISVLVAIAL LKERNPTPAIGLKSPRAMFEQLKAMFSLKVITKPFVVLIALWFMFALFAYNMMVFTLS SYAISKGLSSHDASTLTAILNGSQSIGRPLMGLAGDKFGRANVTIVLTTLLTIYMFAF WIPAHTFVQLIFFSILVGSCVGVANVMNTVLIADMVKPEEFLPAWAFVNYCGAPFLLV CEVIAQALTVEKDKSNPYLHAQIFCGCCFIAALILISILREYSIRMKLTERQAMTNEK LKEWKASEYDTDSADEDWGKLKERKTKYDLLLGPGIKKYFLRMVYPMKV" gene 392892..394370 /gene="NAF1" /locus_tag="YNL124W" mRNA 392892..394370 /gene="NAF1" /locus_tag="YNL124W" /product="RNA-binding snoRNP assembly protein" CDS 392892..394370 /gene="NAF1" /locus_tag="YNL124W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12515383]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:12242285|PMID:12515383]" /experiment="EXISTENCE:mutant phenotype:GO:0000493 box H/ACA snoRNP assembly [PMID:12242285|PMID:12228251|PMID:12515383]" /experiment="EXISTENCE:physical interaction:GO:0000493 box H/ACA snoRNP assembly [PMID:12515383|PMID:12228251]" /experiment="EXISTENCE:physical interaction:GO:0003723 RNA binding [PMID:12515383]" /note="RNA-binding protein required for the assembly of box H/ACA snoRNPs; thus required for pre-rRNA processing; forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p" /codon_start=1 /product="RNA-binding snoRNP assembly protein" /protein_id="DAA10425.1" /db_xref="SGD:S000005068" /translation="MSDDLFSKALENPDQDLNVELPKDDVDLGLLGDGGNERKTDEPV ADAERSTGLGSGSSESESDSGSDSDSDSGSSGSEDDSADQDVEGEDEGGDAIENEDED EDPSPSGPILSKNEILEETVPELPEDYEISEKTIITPIGVLKSAFENNIIIHATMSGE KRVLKEGSIFCLEDRTLIGMLTEVFGPLQNPFYRIKLPDSKKNLFDELKVRLGEKAFI VTPDAHWIDTFELKRNKGTDASNGYDEELPEEEQEFSDDEKEALFKKMKKQQRQRKKR DNRKLANDSDNVKVKRARQPKANSLPKLVPPLGMSSNAPMQHGYKSRNARENIKRESS ATSNRNGSSPVPITQHHQQQFSANNYPFPQQPNGMPYPPYSPFPQPTNFQYPPPPFGQ ATPAQFSNTVPYGSLPPAYNNMSPPTQQSFMPMTQSQPPLPYGVPPMNQMQNPMYIQP PPQAPPQGNGNFQQVMELHQILLQQQQQQHQYQHQHQQDPRT" gene 394685..397678 /gene="NMA111" /locus_tag="YNL123W" /gene_synonym="YNM3" mRNA 394685..397678 /gene="NMA111" /locus_tag="YNL123W" /gene_synonym="YNM3" /product="Nma111p" CDS 394685..397678 /gene="NMA111" /locus_tag="YNL123W" /gene_synonym="YNM3" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14657274|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008236 serine-type peptidase activity [PMID:18946088]" /experiment="EXISTENCE:mutant phenotype:GO:0004252 serine-type endopeptidase activity [PMID:29861160]" /experiment="EXISTENCE:mutant phenotype:GO:0006629 lipid metabolic process [PMID:16470384]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:16608876|PMID:14657274|PMID:16470384]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:18946088]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:29861160]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:18946088]" /experiment="EXISTENCE:mutant phenotype:GO:0120174 stress-induced homeostatically regulated protein degradation pathway [PMID:29861160]" /experiment="EXISTENCE:physical interaction:GO:0006629 lipid metabolic process [PMID:16470384]" /note="Serine protease and general molecular chaperone; cleaves Roq1p, which modifies the substrate specificity of the Ubr1p Ub-ligase, promoting the stress-induced homeostatically-regulated protein degradation (SHRED) of misfolded and native ER-membrane and cytosolic proteins; chaperone activity involved in the heat stress response; promotes apoptosis through proteolysis of Bir1p; role in lipid homeostasis; mammalian Omi/HtrA2 serine protease family member" /codon_start=1 /product="Nma111p" /protein_id="DAA10426.1" /db_xref="SGD:S000005067" /translation="MTISLSNIKKRDHSKISDGTSGESSLVKRKQLESATGDQEEEYT DHEIIIEPLHFANNNNTVLTDSENYLRWQNTISNVVKSVVSIHFSQVAPFDCDSALVS EATGFVVDAKLGIILTNRHVVGPGPFVGYVVFDNHEECDVIPIYRDPVHDFGFLKFDP KNIKYSKIKALTLKPSLAKVGSEIRVVGNDAGEKLSILAGFISRIDRNAPEYGELTYN DFNTEYIQAAASASGGSSGSPVVNIDGYAVALQAGGSTEASTDFFLPLDRILRALICI QTNKPITRGTIQVQWLLKPYDECRRLGLTSERESEARAKFPENIGLLVAETVLREGPG YDKIKEGDTLISINGETISSFMQVDKIQDENVGKEIQLVIQRGGVECTVTCTVGDLHA ITPHRYVEVCGATFHELSYQMARFYALPVRGVFLSSASGSFNFDSKERVGWIVDSIDN KETPDLDTFIEIMKTIPDRKRVTVRYHHLTDQHSPLVTSIYIDRHWCNEFRVYTRNDT TGIWDYKNVADPLPADALKPRSAKIIPIPVNNEKVAKLSSSLCTVATMAAVPLDSLSA DILKTSGLIIDAEKGYVLVSRRVVPHDCLDTFVTIADSLVVPATVEFLHPTHNFAIVK YDPELVKAPLITPKLSTTRMKRGDKLQFIGFTQNDRIVTSETTVTDISSVSIPSNLIP RYRATNLEAISIDCNVSTRCNSGILTDNDGTVRGLWLPFLGERLENKEKVYLMGLDIM DCREVIDILKNGGKPRVSIVDAGFGSISVLQARIRGVPEEWIMRMEHESNNRLQFITV SRVSYTEDKIHLETGDVILSVNGKLVTEMNDLNGVVSSADGILPSAMLDFKVVRDGNI VDLKIKTVEVQETDRFVIFAGSILQKPHHAVLQAMVDVPKGVYCTFRGESSPALQYGI SATNFITHVNEIETPDLDTFLKVVKTIPDNSYCKMRLMTFDNVPFAISLKTNYHYFPT AELKRDNITHKWIEKEFTGNSQSEK" gene complement(398023..398370) /gene="MRP35" /locus_tag="YNL122C" /gene_synonym="bL35m" mRNA complement(398023..398370) /gene="MRP35" /locus_tag="YNL122C" /gene_synonym="bL35m" /product="mitochondrial 54S ribosomal protein MRP35" CDS complement(398023..398370) /gene="MRP35" /locus_tag="YNL122C" /gene_synonym="bL35m" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:24675956]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:24675956]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17054397|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:24675956]" /note="Mitochondrial ribosomal protein of the large subunit; homologous to bacterial L35 and human MRPL35 ribosomal proteins" /codon_start=1 /product="mitochondrial 54S ribosomal protein bL35m MRP35" /protein_id="DAA10427.1" /db_xref="SGD:S000005066" /translation="MKISLHNKRQRGDQNQNMSVFNVLKPLLKGSNSFKVKLNGFLFN NVSTITIRTLMKTHKGTAKRWRRTGNTFKRGIAGRKHGNIGWSHRSLKALTGRKIAHP AYSKHLKRLLPYH" gene complement(398684..400537) /gene="TOM70" /locus_tag="YNL121C" /gene_synonym="MAS70" /gene_synonym="MOM72" /gene_synonym="OMP1" mRNA complement(398684..400537) /gene="TOM70" /locus_tag="YNL121C" /gene_synonym="MAS70" /gene_synonym="MOM72" /gene_synonym="OMP1" /product="protein channel TOM70" CDS complement(398684..400537) /gene="TOM70" /locus_tag="YNL121C" /gene_synonym="MAS70" /gene_synonym="MOM72" /gene_synonym="OMP1" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:11502169]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407|PMID:16689936]" /experiment="EXISTENCE:direct assay:GO:0005742 mitochondrial outer membrane translocase complex [PMID:9774667]" /experiment="EXISTENCE:direct assay:GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site [PMID:37366411]" /experiment="EXISTENCE:direct assay:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:2177474]" /experiment="EXISTENCE:genetic interaction:GO:0006626 protein targeting to mitochondrion [PMID:18007655]" /experiment="EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:2177474]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:8132642]" /experiment="EXISTENCE:mutant phenotype:GO:0030943 mitochondrion targeting sequence binding [PMID:11054285]" /experiment="EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:2177474]" /note="Component of the TOM (translocase of outer membrane) complex; involved in recognition and initial import steps for all mitochondrially-directed proteins, acting as a receptor for incoming precursors; role in the distribution of tail-anchored proteins between mitochondria and peroxisomes; moonlighting role as a transcriptional regulator of mitochondrial proteins; age-dependent reduction in Tom70p results in mitochondrial dysfunction, a hallmark of aging; localizes to mitochondria-ER contact sites" /codon_start=1 /product="protein channel TOM70" /protein_id="DAA10428.1" /db_xref="SGD:S000005065" /translation="MKSFITRNKTAILATVAATGTAIGAYYYYNQLQQQQQRGKKNTI NKDEKKDTKDSQKETEGAKKSTAPSNPPIYPVSSNGEPDFSNKANFTAEEKDKYALAL KDKGNQFFRNKKYDDAIKYYNWALELKEDPVFYSNLSACYVSVGDLKKVVEMSTKALE LKPDYSKVLLRRASANEGLGKFADAMFDLSVLSLNGDFNDASIEPMLERNLNKQAMSK LKEKFGDIDTATATPTELSTQPAKERKDKQENLPSVTSMASFFGIFKPELTFANYDES NEADKELMNGLSNLYKRSPESYDKADESFTKAARLFEEQLDKNNEDEKLKEKLAISLE HTGIFKFLKNDPLGAHEDIKKAIELFPRVNSYIYMALIMADRNDSTEYYNYFDKALKL DSNNSSVYYHRGQMNFILQNYDQAGKDFDKAKELDPENIFPYIQLACLAYRENKFDDC ETLFSEAKRKFPEAPEVPNFFAEILTDKNDFDKALKQYDLAIELENKLDGIYVGIAPL VGKATLLTRNPTVENFIEATNLLEKASKLDPRSEQAKIGLAQMKLQQEDIDEAITLFE ESADLARTMEEKLQAITFAEAAKVQQRIRSDPVLAKKIQETLAKLREQGLM" gene 401040..402521 /gene="NCS2" /locus_tag="YNL119W" /gene_synonym="TUC2" mRNA 401040..402521 /gene="NCS2" /locus_tag="YNL119W" /gene_synonym="TUC2" /product="Ncs2p" CDS 401040..402521 /gene="NCS2" /locus_tag="YNL119W" /gene_synonym="TUC2" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:14551258]" /experiment="EXISTENCE:mutant phenotype:GO:0002143 tRNA wobble position uridine thiolation [PMID:19145231|PMID:18755837|PMID:19151091|PMID:18664566|P MID:17018299]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:14551258]" /experiment="EXISTENCE:mutant phenotype:GO:0032447 protein urmylation [PMID:14551258]" /note="Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs; required for the thiolation of uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae" /codon_start=1 /product="Ncs2p" /protein_id="DAA10429.1" /db_xref="SGD:S000005063" /translation="MECQRCPASARNPATVESRKEKFCDECFIKFVSTKQRKQMMKDE YFRNLFKVIYPFEKEGSVSKILLPLSHSDSGSLVMLDIVHDLLLEQTKQHNNRTGFTV DVLTVFTEENVSVIKERMESLINEKMSQLNKISNIFNVHFIDVNEFFNNASEVSTFII DNENFEIFSKSKSVDDSNILTLKEILGKYCLNNSSRSDLISIIKTQLIKHFAYENGYN AIMWGHSMTKLSEVIISLVVKGKGSQIATFLDSESFDTLNNKPCKYKNLYPMKDLLSV EIESFLQIRNLAQFLINVEETNVKPNCLIARKSLPSLGQQKLVKNMTINEITNKYFQD IQNDYSNIISTVLRTADKLTQPKSSMAKPSQCQICQSKIYTNPSNWLNRITVTSPYPV ETTEEKYLFKQWQDSKLGQSHTHYVELLNEIKQGASNSLDVEDGDVKLCYGCLILLNT SIKDKNLVWPKVDTMDITANATNKNKELSQILDQFEINSDGEE" gene complement(402652..405564) /gene="DCP2" /locus_tag="YNL118C" /gene_synonym="PSU1" mRNA complement(402652..405564) /gene="DCP2" /locus_tag="YNL118C" /gene_synonym="PSU1" /product="decapping enzyme complex catalytic subunit" CDS complement(402652..405564) /gene="DCP2" /locus_tag="YNL118C" /gene_synonym="PSU1" /EC_number="3.6.1.62" /experiment="EXISTENCE:direct assay:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:10508173|PMID:11139489]" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:23509072|PMID:12730603]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:23706738]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:11139489]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:23706738]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:23706738|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0016787 hydrolase activity [PMID:12486012]" /experiment="EXISTENCE:direct assay:GO:0098562 cytoplasmic side of membrane [PMID:27146487]" /experiment="EXISTENCE:direct assay:GO:0098745 RNA decapping complex [PMID:12554866]" /experiment="EXISTENCE:genetic interaction:GO:0034063 stress granule assembly [PMID:20513766]" /experiment="EXISTENCE:mutant phenotype:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:10508173]" /experiment="EXISTENCE:mutant phenotype:GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA [PMID:15225544]" /experiment="EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:20513766]" /experiment="EXISTENCE:mutant phenotype:GO:0060261 positive regulation of transcription initiation by RNA polymerase II [PMID:23706738]" /experiment="EXISTENCE:physical interaction:GO:0098745 RNA decapping complex [PMID:10508173]" /note="Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex; removes 5' cap structure from mRNAs prior to their degradation; also enters nucleus and positively regulates transcription initiation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress; human homolog DCP2 complements yeast dcp2 thermosensitive mutant" /codon_start=1 /product="decapping enzyme complex catalytic subunit" /protein_id="DAA10430.1" /db_xref="SGD:S000005062" /translation="MSLPLRHALENVTSVDRILEDLLVRFIINCPNEDLSSVERELFH FEEASWFYTDFIKLMNPTLPSLKIKSFAQLIIKLCPLVWKWDIRVDEALQQFSKYKKS IPVRGAAIFNENLSKILLVQGTESDSWSFPRGKISKDENDIDCCIREVKEEIGFDLTD YIDDNQFIERNIQGKNYKIFLISGVSEVFNFKPQVRNEIDKIEWFDFKKISKTMYKSN IKYYLINSMMRPLSMWLRHQRQIKNEDQLKSYAEEQLKLLLGITKEEQIDPGRELLNM LHTAVQANSNNNAVSNGQVPSSQELQHLKEQSGEHNQQKDQQSSFSSQQQPSIFPSLS EPFANNKNVIPPTMPMANVFMSNPQLFATMNGQPFAPFPFMLPLTNNSNSANPIPTPV PPNFNAPPNPMAFGVPNMHNLSGPAVSQPFSLPPAPLPRDSGYSSSSPGQLLDILNSK KPDSNVQSSKKPKLKILQRGTDLNSIKQNNNDETAHSNSQALLDLLKKPTSSQKIHAS KPDTSFLPNDSVSGIQDAEYEDFESSSDEEVETARDERNSLNVDIGVNVMPSEKDSRR SQKEKPRNDASKTNLNASAESNSVEWGPGKSSPSTQSKQNSSVGMQNKYRQEIHIGDS DAYEVFESSSDEEDGKKLEELEQTQDNSKLISQDILKENNFQDGEVPHRDMPTESNKS INETVGLSSTTNTVKKVPKVKILKRGETFASLANDKKAFDSSSNVSSSKDLLQMLRNP ISSTVSSNQQSPKSQHLSGDEEIMMMLKRNSVSKPQNSEENASTSSINDANASELLGM LKQKEKDITAPKQPYNVDSYSQKNSAKGLLNILKKNDSTGYPRTEGGPSSEMSTSMKR NDATNNQELDKNSTELLNYLKPKPLNDGYENISNKDSSHELLNILHGNKNSSAFNNNV YATDGYSLASDNNENSSNKLLNMLQNRSSAINEPNFDVRSNGTSGSNELLSILHRK" gene 406358..408022 /gene="MLS1" /locus_tag="YNL117W" mRNA 406358..408022 /gene="MLS1" /locus_tag="YNL117W" /product="malate synthase MLS1" CDS 406358..408022 /gene="MLS1" /locus_tag="YNL117W" /EC_number="2.3.3.9" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:27678487|PMID:2211514]" /experiment="EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:11846793]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:11846793]" /experiment="EXISTENCE:mutant phenotype:GO:0004474 malate synthase activity [PMID:23642236|PMID:8878673]" /experiment="EXISTENCE:mutant phenotype:GO:0006097 glyoxylate cycle [PMID:8878673|PMID:23642236]" /note="Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA" /codon_start=1 /product="malate synthase MLS1" /protein_id="DAA10431.1" /db_xref="SGD:S000005061" /translation="MVKVSLDNVKLLVDVDKEPFFKPSSTTVGDILTKDALEFIVLLH RTFNNKRKQLLENRQVVQKKLDSGSYHLDFLPETANIRNDPTWQGPILAPGLINRSTE ITGPPLRNMLINALNAPVNTYMTDFEDSASPTWNNMVYGQVNLYDAIRNQIDFDTPRK SYKLNGNVANLPTIIVRPRGWHMVEKHLYVDDEPISASIFDFGLYFYHNAKELIKLGK GPYFYLPKMEHHLEAKLWNDVFCVAQDYIGIPRGTIRATVLIETLPAAFQMEEIIYQL RQHSSGLNCGRWDYIFSTIKRLRNDPNHILPNRNQVTMTSPFMDAYVKRLINTCHRRG VHAMGGMAAQIPIKDDPAANEKAMTKVRNDKIRELTNGHDGSWVAHPALAPICNEVFI NMGTPNQIYFIPENVVTAANLLETKIPNGEITTEGIVQNLDIGLQYMEAWLRGSGCVP INNLMEDAATAEVSRCQLYQWVKHGVTLKDTGEKVTPELTEKILKEQVERLSKASPLG DKNKFALAAKYFLPEIRGEKFSEFLTTLLYDEIVSTKATPTDLSKL" gene 408341..409909 /gene="DMA2" /locus_tag="YNL116W" /gene_synonym="CHF2" mRNA 408341..409909 /gene="DMA2" /locus_tag="YNL116W" /gene_synonym="CHF2" /product="ubiquitin-conjugating protein DMA2" CDS 408341..409909 /gene="DMA2" /locus_tag="YNL116W" /gene_synonym="CHF2" /EC_number="2.3.2.27" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:18202552]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0051865 protein autoubiquitination [PMID:18202552]" /experiment="EXISTENCE:genetic interaction:GO:0000132 establishment of mitotic spindle orientation [PMID:15146058|PMID:22570619]" /experiment="EXISTENCE:genetic interaction:GO:0000921 septin ring assembly [PMID:22570619|PMID:15146058]" /experiment="EXISTENCE:genetic interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:21562220]" /experiment="EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:22570619|PMID:15146058]" /experiment="EXISTENCE:genetic interaction:GO:0032186 cellular bud neck septin ring organization [PMID:22570619]" /experiment="EXISTENCE:genetic interaction:GO:0097271 protein localization to bud neck [PMID:22570619]" /experiment="EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:18202552]" /experiment="EXISTENCE:mutant phenotype:GO:0005934 cellular bud tip [PMID:23442799]" /experiment="EXISTENCE:mutant phenotype:GO:0032177 cellular bud neck split septin rings [PMID:23442799]" /experiment="EXISTENCE:mutant phenotype:GO:0090337 regulation of formin-nucleated actin cable assembly [PMID:27449057]" /experiment="EXISTENCE:physical interaction:GO:0090337 regulation of formin-nucleated actin cable assembly [PMID:27449057]" /note="Ubiquitin-protein ligase (E3); controls septin dynamics and spindle position checkpoint (SPOC) with ligase Dma1p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8, similar to human Chfr; contains FHA and RING finger domains; DMA2 has a paralog, DMA1, that arose from the whole genome duplication" /codon_start=1 /product="ubiquitin-conjugating protein DMA2" /protein_id="DAA10432.1" /db_xref="SGD:S000005060" /translation="MYTPIPANTPAPTAPTSSMTSNSSSASNANTTSSSGINPRNRAS GTPSNERARPASGISSFLNTFGIRQNSQTASSSAAPDQRLFGTTPSNSHMSVAMESID TAPQQQEPRLHHPIQMPLSAQFHVHRNYQLPISISLTAPTTTDHQQSSAHNFEGNNVG NVQESLNQRQPNGTNNTTTSIISMAPAATTRNIVGGADGSTIVNNSQEMYKNLRHLIY AANQPNGTEILHLDLPATSAEESNNMFNVDEVTLKQRKDKHGLFSIRLTPFIDSSSTT NQGLFFEPIIRKAGPGSQLVIGRYTERVRDAISKIPEQYHPVVFKSKVVSRTHGCFKV DSQGNWYIKDVKSSSGTFLNHQRLSPASSLSKDTPLRDGDILQLGMDFRGGTEEIYRC VRMRIELNRSWKLKANSFNKEALQRLQNLQKLTTGIEEEDCSICLCKIKPCQAIFISP CAHSWHFRCVRRLVMLSYPQFVCPNCRSSCDLEASFESSDEEDESDVESEGDQLVDQL SVLMETSKDVDSHP" gene complement(410119..412053) /locus_tag="YNL115C" mRNA complement(410119..412053) /locus_tag="YNL115C" /product="hypothetical protein" CDS complement(410119..412053) /locus_tag="YNL115C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10433.1" /db_xref="SGD:S000005059" /translation="MKANGLDNDPARTGMERTDIDSEHPEAQPLLNNNHRTLGAGSAN GPAVNEGRDIESDGFIKDSLFQIRKGYRIFIHNSKWILNILILINTIWLVTTLISDFF FNINILFGFSNRYASFNDLTLIFISIIANSFNLWFNKLGLYSALDYSLNVTLCVLTLF NLALTYLIKYTRQRIGFVGTFTYLWTSFSFFIGAILDWYLLFYNNSINEPLEERRIDD ANISTFNENHTNSTENRDRSQYGSGSPTPTHRSQLVQNKHTLTEWVSIGFRNTIKFLI LIFFALFTLNTLLTTLDTYRLTHKLPITVQSPSYEAFHYVDAAKTYQLHITCYGDVFD QENNTDLSENKKQPIILFEHGGYDTGYLSATWIEELYHLDKIQRYCLYDRPGYGLSDS PPAPISIAMVAESLRYALIKDAKIKGPFTTVGYDLGGLFTRVFTAKNVDIVDSMMLVE SWHEELLLKNYIQRLLPPGRGDGDDGDDGNGNDGDGRNHDKTWLPSEIERHNEFRLWW KGIWSSLGWRLQTSWLLAHHGSKERIYGRDMKYQGRFLRSKFLESVTSSILSYRDVTN NAESLQNVKTSIVSSKEMVKKSALWGDWQRDLTKISHKTQEWKIVEGGHEIYKYGLGK QQTQEVLLRLIGELGKLTED" rep_origin 412267..412496 /note="ARS1417; Autonomously Replicating Sequence" /db_xref="SGD:S000118386" gene 412771..413199 /gene="RPC19" /locus_tag="YNL113W" mRNA 412771..413199 /gene="RPC19" /locus_tag="YNL113W" /product="DNA-directed RNA polymerase core subunit RPC19" CDS 412771..413199 /gene="RPC19" /locus_tag="YNL113W" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:3905793|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:3905793|PMID:10611227]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /note="RNA polymerase subunit AC19; common to RNA polymerases I and III" /codon_start=1 /product="DNA-directed RNA polymerase core subunit RPC19" /protein_id="DAA10434.1" /db_xref="SGD:S000005057" /translation="MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDR EKIKLLTQATSEDGTSASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLN IRIQTYGETTAVDALQKGLKDLMDLCDVVESKFTEKIKSM" gene 413639..416281 /gene="DBP2" /locus_tag="YNL112W" mRNA join(413639..414911,415914..416281) /gene="DBP2" /locus_tag="YNL112W" /product="DEAD-box ATP-dependent RNA helicase DBP2" CDS join(413639..414911,415914..416281) /gene="DBP2" /locus_tag="YNL112W" /EC_number="3.6.4.13" /experiment="EXISTENCE:direct assay:GO:0002151 G-quadruplex RNA binding [PMID:30855040]" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:23721653]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:30902808]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22679025]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0006369 termination of RNA polymerase II transcription [PMID:30902808]" /experiment="EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:22679025]" /experiment="EXISTENCE:direct assay:GO:0030515 snoRNA binding [PMID:30902808]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:30855040]" /experiment="EXISTENCE:genetic interaction:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:22679025]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:11585918]" /experiment="EXISTENCE:mutant phenotype:GO:0008186 ATP-dependent activity, acting on RNA [PMID:22679025]" /experiment="EXISTENCE:mutant phenotype:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:22679025]" /experiment="EXISTENCE:physical interaction:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:7883168]" /note="ATP-dependent RNA helicase of the DEAD-box protein family; strong preference for dsRNA; remodels RNP structure for efficient transcription termination; required for assembly of Yra1p, Nab2p and Mex67p onto mRNA and formation of nuclear mRNP; involved in mRNA decay and rRNA processing; may suppress transcription from cryptic initiation sites; promotes Mex67p-mediated nuclear export of mRNA by facilitating annealing with antisense RNAs to create dsRNAs; binds G-quadruplex (G4) nucleic acids" /codon_start=1 /product="DEAD-box ATP-dependent RNA helicase DBP2" /protein_id="DAA10435.1" /db_xref="SGD:S000005056" /translation="MTYGGRDQQYNKTNYKSRGGDFRGGRNSDRNSYNDRPQGGNYRG GFGGRSNYNQPQELIKPNWDEELPKLPTFEKNFYVEHESVRDRSDSEIAQFRKENEMT ISGHDIPKPITTFDEAGFPDYVLNEVKAEGFDKPTGIQCQGWPMALSGRDMVGIAATG SGKTLSYCLPGIVHINAQPLLAPGDGPIVLVLAPTRELAVQIQTECSKFGHSSRIRNT CVYGGVPKSQQIRDLSRGSEIVIATPGRLIDMLEIGKTNLKRVTYLVLDEADRMLDMG FEPQIRKIVDQIRPDRQTLMWSATWPKEVKQLAADYLNDPIQVQVGSLELSASHNITQ IVEVVSDFEKRDRLNKYLETASQDNEYKTLIFASTKRMCDDITKYLREDGWPALAIHG DKDQRERDWVLQEFRNGRSPIMVATDVAARGIDVKGINYVINYDMPGNIEDYVHRIGR TGRAGATGTAISFFTEQNKGLGAKLISIMREANQNIPPELLKYDRRSYGGGHPRYGGG RGGRGGYGRRGGYGGGRGGYGGNRQRDGGWGNRGRSNY" gene complement(416940..417302) /gene="CYB5" /locus_tag="YNL111C" mRNA complement(416940..417302) /gene="CYB5" /locus_tag="YNL111C" /product="Cyb5p" CDS complement(416940..417302) /gene="CYB5" /locus_tag="YNL111C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12514182]" /experiment="EXISTENCE:direct assay:GO:0009055 electron transfer activity [PMID:10622712]" /experiment="EXISTENCE:direct assay:GO:0016126 sterol biosynthetic process [PMID:10622712]" /note="Cytochrome b5; involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation" /codon_start=1 /product="Cyb5p" /protein_id="DAA10436.1" /db_xref="SGD:S000005055" /translation="MPKVYSYQEVAEHNGPENFWIIIDDKVYDVSQFKDEHPGGDEII MDLGGQDATESFVDIGHSDEALRLLKGLYIGDVDKTSERVSVEKVSTSENQSKGSGTL VVILAILMLGVAYYLLNE" gene complement(417826..418488) /gene="NOP15" /locus_tag="YNL110C" mRNA complement(417826..418488) /gene="NOP15" /locus_tag="YNL110C" /product="rRNA-binding ribosome biosynthesis protein NOP15" CDS complement(417826..418488) /gene="NOP15" /locus_tag="YNL110C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10953080]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11583614]" /experiment="EXISTENCE:direct assay:GO:0006364 rRNA processing [PMID:27643814]" /experiment="EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:27643814]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350|PMID:23212245]" /experiment="EXISTENCE:direct assay:GO:0042273 ribosomal large subunit biogenesis [PMID:27643814]" /experiment="EXISTENCE:direct assay:GO:0043023 ribosomal large subunit binding [PMID:27643814]" /note="Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm" /codon_start=1 /product="rRNA-binding ribosome biosynthesis protein NOP15" /protein_id="DAA10437.1" /db_xref="SGD:S000005054" /translation="MVKSTSKTSTKETVTKQPTEEKPIQEKEELALETSSSSSDEEDE KDEDEIEGLAASDDEQSGTHKIKRLNPKKQANEKKSKDKKTLEEYSGIIYVSRLPHGF HEKELSKYFAQFGDLKEVRLARNKKTGNSRHYGFLEFVNKEDAMIAQESMNNYLLMGH LLQVRVLPKGAKIEKLYKYKKRVLVEKGITKPVKQLKDNMKQKHEERIKKLAKSGIEF KW" gene complement(419014..419826) /locus_tag="YNL108C" /gene_synonym="HUF" mRNA complement(419014..419826) /locus_tag="YNL108C" /gene_synonym="HUF" /product="hypothetical protein" CDS complement(419014..419826) /locus_tag="YNL108C" /gene_synonym="HUF" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016311 dephosphorylation [PMID:23569204]" /experiment="EXISTENCE:direct assay:GO:0016791 phosphatase activity [PMID:23569204]" /note="Protein phosphatase; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10438.1" /db_xref="SGD:S000005052" /translation="MAIENIYIARHGYRSNWLPKGPYPPPPTGIDNDVPLSEHGVEQA HELANYISKLDVKPEMIFSSPFYRCLETSKPTVEALKIPLYVDRGVGEWYKPDRPIIP EPATHEVMSKFFPSMISPDWEPSIIPSNKGETEEDIFERCHKFWPVFIDRVERKFPNV KTIMIVTHAATKSALGMNLLKFSSAKEPIDNKGTFIRNGSCAIDKFELVKGENESIPF EEREWKLTMNGNTSFLTNGEEMNWTFMNAFEAGSDADIKARRAAESGKLKME" gene 420098..420778 /gene="YAF9" /locus_tag="YNL107W" mRNA 420098..420778 /gene="YAF9" /locus_tag="YNL107W" /product="YEATS domain-containing protein YAF9" CDS 420098..420778 /gene="YAF9" /locus_tag="YNL107W" /experiment="EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:14690608|PMID:14645854]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:14645854]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15485911]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:15485911]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:15302830]" /note="Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes; may function to antagonize silencing near telomeres; interacts directly with Swc4p; has homology to human leukemogenic protein AF9; contains a YEATS domain" /codon_start=1 /product="YEATS domain-containing protein YAF9" /protein_id="DAA10439.1" /db_xref="SGD:S000005051" /translation="MAPTISKRIKTLSVSRPIIYGNTAKKMGSVKPPNAPAEHTHLWT IFVRGPQNEDISYFIKKVVFKLHDTYPNPVRSIEAPPFELTETGWGEFDINIKVYFVE EANEKVLNFYHRLRLHPYANPVPNSDNGNEQNTTDHNSKDAEVSSVYFDEIVFNEPNE EFFKILMSRPGNLLPSNKTDDCVYSKQLEQEEIDRIEIGIEKVDKEIDELKQKLENLV KQEAINGS" gene complement(420944..424495) /gene="INP52" /locus_tag="YNL106C" /gene_synonym="SJL2" mRNA complement(420944..424495) /gene="INP52" /locus_tag="YNL106C" /gene_synonym="SJL2" /product="phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52" CDS complement(420944..424495) /gene="INP52" /locus_tag="YNL106C" /gene_synonym="SJL2" /EC_number="3.1.3.36" /experiment="EXISTENCE:direct assay:GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity [PMID:10224048]" /experiment="EXISTENCE:direct assay:GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [PMID:10224048]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11094088]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:15798181|PMID:11094088]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity [PMID:10224048]" /experiment="EXISTENCE:direct assay:GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [PMID:10224048]" /experiment="EXISTENCE:direct assay:GO:0046856 phosphatidylinositol dephosphorylation [PMID:10224048]" /experiment="EXISTENCE:mutant phenotype:GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [PMID:9438131]" /experiment="EXISTENCE:mutant phenotype:GO:0046856 phosphatidylinositol dephosphorylation [PMID:9438131]" /experiment="EXISTENCE:physical interaction:GO:0030479 actin cortical patch [PMID:15798181]" /note="Polyphosphatidylinositol phosphatase; dephosphorylates a number of phosphatidylinositol phosphates (PtdInsPs, PIPs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain; INP52 has a paralog, INP53, that arose from the whole genome duplication" /codon_start=1 /product="phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52" /protein_id="DAA10440.1" /db_xref="SGD:S000005050" /translation="MKILLSKQQTRKIAIVSETHGLVFRPINSKNSRRSTCAVELVPK AELNGNGFRRLSNHEIYGFIGLIEIEGLMFIATITGKSKVAQPIPNKTVNKIYAVDFF CLNNSKWDFMDIDSSGYPIVTNDGDFAISSPPSISTHSSRSSLRSSSSRSLNAQEQAP KHPCHELRKLLSNGSFYYSTDFDLTCTLQKRGFTEHSLSFDDFDREFMWNSFLMDEII TYRDRLDVTAKELLDQRGFLTTVIRGFAETIFSYINRLKVGLTIISRQSWKRAGTRFN ARGIDDDGHVANFVETEMIMYSSQYCYAFTQIRGSLPIFWEQDTSLISPKIQITRSVE ATQPTFDEHFIRLFKKYGPVHIINLLSTKSSEIQLSRRYKEQLKNSEKMKIGRDVFLT SFDFHRETSQDGFAAASRIIPKIRNTILDAGYFSYDVKEGRLISEQDGVFRTNCLDCL DRTNLIQQTISLAVFKLFLEDFRLVKPSSFIDDNEFVQKVNALWADNGDQISQIYTGT NALKSSYSRKGKMSFSGALSDATKSVSRMYINNFVDKGKQQNIDTLLGKLPHQQVVEL YDPICEYVNERLLESEEKFTTHSNINLFVGTFNVNGNSRRADLSKWLFPIGDKFKPDV VVLGLQEVIELTAGSILNADYTKSSFWETMVTDCLNQYEEKYLLLRVEQMSSLLILFF ARSDRAYNIKEVGGSTKKTGFGGITGNKGAVAIRFDYGATSFCFVNTHLSAGASNIDE RRNDYNNIYRNITFPRSKTIPHHDSLFWLGDLNYRITLTNDEVRRELRAQKDGYIDRL LQYDQLTQEINEGVVFQGFKEPTLQFRPTYKYDYGTDNYDTSEKARTPSWTDRIIYKG ENLHPLAYSDAPLKISDHKPVYAAYRANVKFVDEKEKLNLVEKLYAEYKNTHPEALTT GPDELSHARMEKQKESIPLDATVQSAGIKLIDLDDTSSCVSPLLSGPSPQPSVVGPGG LSNVSPDKSKLNVLPPPPPTSRHNKEPSSKLLSPTKEISIVSVSPRKGESNLPALERH STPKPLPPVPALSLSKPVSLQKSSSELQHAKETIDNGKIVPRPCPPIRRKSSTAPDEI STSTKNSGVSTTEDPEPAKASTKPEKPPVVKKPHYLSVAANKLNTSQEHSIKVSPSNS KSEEELPCKKKSKPKVPAKNPELEKLSVHPLKPCDPN" gene complement(424895..426754) /gene="LEU4" /locus_tag="YNL104C" mRNA complement(424895..426754) /gene="LEU4" /locus_tag="YNL104C" /product="2-isopropylmalate synthase LEU4" CDS complement(424895..426754) /gene="LEU4" /locus_tag="YNL104C" /EC_number="2.3.3.13" /experiment="EXISTENCE:direct assay:GO:0003852 2-isopropylmalate synthase activity [PMID:3275644|PMID:25841022]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:3275644|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:3275644|PMID:16823961|PMID:14562095|PMID:24769239|PM ID:11914276|PMID:14576278|PMID:25841022]" /experiment="EXISTENCE:genetic interaction:GO:0009098 L-leucine biosynthetic process [PMID:10790691]" /experiment="EXISTENCE:mutant phenotype:GO:0009098 L-leucine biosynthetic process [PMID:25841022]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:25841022]" /note="Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication" /codon_start=1 /product="2-isopropylmalate synthase LEU4" /protein_id="DAA10441.1" /db_xref="SGD:S000005048" /translation="MVKESIIALAEHAASRASRVIPPVKLAYKNMLKDPSSKYKPFNA PKLSNRKWPDNRITRAPRWLSTDLRDGNQSLPDPMSVEQKKEYFHKLVNIGFKEIEVS FPSASQTDFDFTRYAVENAPDDVSIQCLVQSREHLIKRTVEALTGAKKATIHTYLATS DMFREIVFNMSREEAISKAVEATKLVRKLTKDDPSQQATRWSYEFSPECFSDTPGEFA VEICEAVKKAWEPTEENPIIFNLPATVEVASPNVYADQIEYFATHITEREKVCISTHC HNDRGCGVAATELGMLAGADRVEGCLFGNGERTGNVDLVTVAMNMYTQGVSPNLDFSD LTSVLDVVERCNKIPVSQRAPYGGDLVVCAFSGSHQDAIKKGFNLQNKKRAQGETQWR IPYLPLDPKDIGRDYEAVIRVNSQSGKGGAAWVILRSLGLDLPRNMQIEFSSAVQDHA DSLGRELKSDEISKLFKEAYNYNDEQYQAISLVNYNVEKFGTERRVFTGQVKVGDQIV DIEGTGNGPISSLVDALSNLLNVRFAVANYTEHSLGSGSSTQAASYIHLSYRRNADNE KAYKWGVGVSEDVGDSSVRAIFATINNIIHSGDVSIPSLAEVEGKNAAASGSA" gene 427735..429753 /gene="MET4" /locus_tag="YNL103W" mRNA 427735..429753 /gene="MET4" /locus_tag="YNL103W" /product="Met4p" CDS 427735..429753 /gene="MET4" /locus_tag="YNL103W" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:9799240]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9799240]" /experiment="EXISTENCE:direct assay:GO:0046685 response to arsenic-containing substance [PMID:15689486]" /experiment="EXISTENCE:direct assay:GO:0046686 response to cadmium ion [PMID:15689486]" /experiment="EXISTENCE:direct assay:GO:0089713 Cbf1-Met4-Met28 complex [PMID:8665859|PMID:9171357]" /experiment="EXISTENCE:mutant phenotype:GO:0000096 sulfur amino acid metabolic process [PMID:1549123]" /experiment="EXISTENCE:mutant phenotype:GO:0010438 cellular response to sulfur starvation [PMID:39138175]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:39138175]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:22696683|PMID:39138175]" /experiment="EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:9799240]" /note="Leucine-zipper transcriptional activator; regulates the sulfur amino acid pathway; requires different combinations of auxiliary factors Cbf1p, Met28p, Met31p and Met32p; specific involvement in sulfur starvation-induced autophagy with Gcn4p; feedforward loop exists in the regulation of genes controlled by Met4p and Met32p; ubiquitinated by SCF-Met30p, leading to either degradation or maintenance in an inactive state; regulates degradation of its DNA-binding cofactors by SCF-Met30p targeting" /codon_start=1 /product="Met4p" /protein_id="DAA10442.1" /db_xref="SGD:S000005047" /translation="MKQEQSHEGDSYSTEFINLFGKDTATHPSSNNGANNNGMGSTNS LDQFVATASSSSSLVTSSENRRPLIGDVTNRGNTNLYDHAVTPEILLEQLAYVDNFIP SLDNEFSNVDWNVNTTHNNANNNGADTFSSINANPFDLDEQLAIELSAFADDSFIFPD EDKPSNNNNNSNNGNDDHSNHDVLHEDPSTNNRQRNPHFLTQRRNTFLTSQYDQSKSR FSSKNKRNGNNGETNNFGDNMQNNHPFEPNFMGSPSQFPADATNMTSIDHGGFTNVDI TSTENNTTGDNGVDALSNLLHRTTHTPNRSSPLSNVTSAQNSSSQQRKHSESKVDSNS DNNSSNKAPNITVPDYSIIPTSVLVTLLPRVNVPNGAYNSLISAGFDNDQIDAIAAIM AYHHQKKIRENNSNNNKNINTNDSQEAPILKNINELLSVLIPPSPAETAAPTTLSTSP SFNEHGVVAEASFLSSILELGIKHPKSNNIHNQRQPSRNDHKISRESDGNNGNDNVHH NNAVIKSSTTRGDEIAKIRSEPTLNASSSDHKENSLKRSHSGDLKNKKVPVDRKYSDN EDDEYDDADLHGFEKKQLIKKELGDDDEDLLIQSKKSHQKKKLKEKELESSIHELTEI AASLQKRIHTLETENKLLKNLVLSSGETEGIKKAESLKKQIFEKVQKE" gene 430087..434493 /gene="POL1" /locus_tag="YNL102W" /gene_synonym="CDC17" /gene_synonym="CRT5" /gene_synonym="HPR3" mRNA 430087..434493 /gene="POL1" /locus_tag="YNL102W" /gene_synonym="CDC17" /gene_synonym="CRT5" /gene_synonym="HPR3" /product="DNA-directed DNA polymerase alpha catalytic subunit POL1" CDS 430087..434493 /gene="POL1" /locus_tag="YNL102W" /gene_synonym="CDC17" /gene_synonym="CRT5" /gene_synonym="HPR3" /EC_number="2.7.7.7" /experiment="EXISTENCE:direct assay:GO:0000510 H3-H4 histone complex chaperone activity [PMID:38713623]" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:1704371|PMID:3907855|PMID:3888995]" /experiment="EXISTENCE:direct assay:GO:0005657 replication fork [PMID:15773893]" /experiment="EXISTENCE:direct assay:GO:0005658 alpha DNA polymerase:primase complex [PMID:3888995|PMID:22593576]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006278 RNA-templated DNA biosynthetic process [PMID:17429354]" /experiment="EXISTENCE:mutant phenotype:GO:0000510 H3-H4 histone complex chaperone activity [PMID:38713623]" /experiment="EXISTENCE:mutant phenotype:GO:0000731 DNA synthesis involved in DNA repair [PMID:2651896]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:2651896]" /experiment="EXISTENCE:mutant phenotype:GO:0006279 premeiotic DNA replication [PMID:2651896]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:10025407]" /note="Catalytic subunit of the DNA polymerase I alpha-primase complex; required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis; H3-H4 histone chaperone, downstream of Pol32p, involved in the transfer of parental histones to the lagging strand during DNA replication" /codon_start=1 /product="DNA-directed DNA polymerase alpha catalytic subunit POL1" /protein_id="DAA10443.1" /db_xref="SGD:S000005046" /translation="MSSKSEKLEKLRKLQAARNGTSIDDYEGDESDGDRIYDEIDEKE YRARKRQELLHDDFVVDDDGVGYVDRGVEEDWREVDNSSSDEDTGNLASKDSKRKKNI KREKDHQITDMLRTQHSKSTLLAHAKKSQKKSIPIDNFDDILGEFESGEVEKPNILLP SKLRENLNSSPTSEFKSSIKRVNGNDESSHDAGISKKVKIDPDSSTDKYLEIESSPLK LQSRKLRYANDVQDLLDDVENSPVVATKRQNVLQDTLLANPPSAQSLADEEDDEDSDE DIILKRRTMRSVTTTRRVNIDSRSNPSTSPFVTAPGTPIGIKGLTPSKSLQSNTDVAT LAVNVKKEDVVDPETDTFQMFWLDYCEVNNTLILFGKVKLKDDNCVSAMVQINGLCRE LFFLPREGKTPTDIHEEIIPLLMDKYGLDNIRAKPQKMKYSFELPDIPSESDYLKVLL PYQTPKSSRDTIPSDLSSDTFYHVFGGNSNIFESFVIQNRIMGPCWLDIKGADFNSIR NASHCAVEVSVDKPQNITPTTTKTMPNLRCLSLSIQTLMNPKENKQEIVSITLSAYRN ISLDSPIPENIKPDDLCTLVRPPQSTSFPLGLAALAKQKLPGRVRLFNNEKAMLSCFC AMLKVEDPDVIIGHRLQNVYLDVLAHRMHDLNIPTFSSIGRRLRRTWPEKFGRGNSNM NHFFISDICSGRLICDIANEMGQSLTPKCQSWDLSEMYQVTCEKEHKPLDIDYQNPQY QNDVNSMTMALQENITNCMISAEVSYRIQLLTLTKQLTNLAGNAWAQTLGGTRAGRNE YILLHEFSRNGFIVPDKEGNRSRAQKQRQNEENADAPVNSKKAKYQGGLVFEPEKGLH KNYVLVMDFNSLYPSIIQEFNICFTTVDRNKEDIDELPSVPPSEVDQGVLPRLLANLV DRRREVKKVMKTETDPHKRVQCDIRQQALKLTANSMYGCLGYVNSRFYAKPLAMLVTN KGREILMNTRQLAESMNLLVVYGDTDSVMIDTGCDNYADAIKIGLGFKRLVNERYRLL EIDIDNVFKKLLLHAKKKYAALTVNLDKNGNGTTVLEVKGLDMKRREFCPLSRDVSIH VLNTILSDKDPEEALQEVYDYLEDIRIKVETNNIRIDKYKINMKLSKDPKAYPGGKNM PAVQVALRMRKAGRVVKAGSVITFVITKQDEIDNAADTPALSVAERAHALNEVMIKSN NLIPDPQYYLEKQIFAPVERLLERIDSFNVVRLSEALGLDSKKYFRREGGNNNGEDIN NLQPLETTITDVERFKDTVTLELSCPSCDKRFPFGGIVSSNYYRVSYNGLQCKHCEQL FTPLQLTSQIEHSIRAHISLYYAGWLQCDDSTCGIVTRQVSVFGKRCLNDGCTGVMRY KYSDKQLYNQLLYFDSLFDCEKNKKQELKPIYLPDDLDYPKEQLTESSIKALTEQNRE LMETGRSVVQKYLNDCGRRYVDMTSIFDFMLN" gene 434999..437140 /gene="AVT4" /locus_tag="YNL101W" mRNA 434999..437140 /gene="AVT4" /locus_tag="YNL101W" /product="Avt4p" CDS 434999..437140 /gene="AVT4" /locus_tag="YNL101W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:11274162]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]" /experiment="EXISTENCE:genetic interaction:GO:0005302 L-tyrosine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:genetic interaction:GO:0015186 L-glutamine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:genetic interaction:GO:0015188 L-isoleucine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:genetic interaction:GO:0032974 amino acid transmembrane export from vacuole [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0005302 L-tyrosine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0015186 L-glutamine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0015188 L-isoleucine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0032974 amino acid transmembrane export from vacuole [PMID:11274162]" /note="Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs)" /codon_start=1 /product="Avt4p" /protein_id="DAA10444.1" /db_xref="SGD:S000005045" /translation="MVTNNGDGEHLGIRRNGNLRHPSNNMKIPRRAQSTVLNSNPFYS RKYSMSTLTPRDICRSVDSRVFVDMSSPNFQTLEDPHRDEIINSVRLNYLNSSKRSSV SHGNEAIPRVNPTKNSSASTIAAANVDSDDDETNLSSAGGDITHDIYKLVKAEDPKRL RRPRSMENVTPKIEHHTKLSSASGLNVPGGFRREFIVNKKRQEHQLNDSASSDFTSHE SDSINQSSPSSNQDIDKVPFLTRNFLEFLYVFGHFAGESFEDDFIPDSSNMMIRGEDE RSALLSRPDHMKVLPSAKGTTSTKKVFLILLKSFIGTGVLFLPNAFHNGGLFFSVSML AFFGIYSYWCYYILVQAKSSCGVSSFGDIGLKLYGPWMRIIILFSLVITQVGFSGAYM IFTAKNLQAFLDNVFHVGVLPLSYLMVFQTIIFIPLSFIRNISKLSLPSLLANFFIMA GLVIVIIFTAKRLFFDLMGTPAMGVVYGLNADRWTLFIGTAIFAFEGIGLIIPVQDSM RNPEKFPLVLALVILTATILFISIATLGYLAYGSNVQTVILLNLPQSNIFVNLIQLFY SIAIMLSTPLQLFPAIKIIENKFFPKFTKIYVKHDDLTTRVELRPNSGKLNWKIKWLK NFIRSIIVIIVVSIAYFGSDNLDKFVSVIGSLACIPLVYIYPSMLHLRGNSLPETKGE FWRFKPMLDTILIFFGIASMLYTSYQSIFGV" gene 437613..438317 /gene="MIC27" /locus_tag="YNL100W" /gene_synonym="AIM37" /gene_synonym="MCS27" mRNA 437613..438317 /gene="MIC27" /locus_tag="YNL100W" /gene_synonym="AIM37" /gene_synonym="MCS27" /product="Mic27p" CDS 437613..438317 /gene="MIC27" /locus_tag="YNL100W" /gene_synonym="AIM37" /gene_synonym="MCS27" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:14562095|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0044284 mitochondrial crista junction [PMID:22009199]" /experiment="EXISTENCE:direct assay:GO:0061617 MICOS complex [PMID:21944719|PMID:21987634|PMID:22009199]" /experiment="EXISTENCE:mutant phenotype:GO:0032461 positive regulation of protein oligomerization [PMID:29733859]" /experiment="EXISTENCE:mutant phenotype:GO:0042407 cristae formation [PMID:22009199|PMID:21944719|PMID:21987634]" /experiment="EXISTENCE:mutant phenotype:GO:0043933 protein-containing complex organization [PMID:26968360]" /note="Component of the MICOS complex; MICOS (formerly MINOS or MitOS), a mitochondrial inner membrane complex that extends into the intermembrane space with a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic10p and Mic12p whose assembly and stability requires cardiolipin; positive regulator of Mic10p oligomerization along with cardiolipin; orthologous to human APOO and APOOL" /codon_start=1 /product="Mic27p" /protein_id="DAA10445.1" /db_xref="SGD:S000005044" /translation="MVNFYDDVDESKSHGEFPLIPVVLQNSSELSVRTIPTGNEIIES VHLTKWLRKYRNALASQLDRYEKGWQSKIANFRLQVQHVINYSRKNIFNVDSENKHTV VPGSLIALGAFFAGSIAVNRSNWGAKRLIFGHKSSILEKLCTSLPSRILLPWVLAAAT FKYWAPQTSQNLVNATENDLLPADFVKSYHNTWKRIYEEGYVAKKCDLKRQIDQTLQK NIRYAREQLYEKLEQA" gene complement(438567..439283) /gene="OCA1" /locus_tag="YNL099C" mRNA complement(438567..439283) /gene="OCA1" /locus_tag="YNL099C" /product="putative tyrosine protein phosphatase OCA1" CDS complement(438567..439283) /gene="OCA1" /locus_tag="YNL099C" /EC_number="3.1.3.48" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016791 phosphatase activity [PMID:40212001]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:11408586]" /note="Putative protein tyrosine phosphatase; contains phosphatase activity using the non-specific phosphatase substrate, pNPP, and is inhibited by sodium orthovanadate; required for cell cycle arrest in response to oxidative damage of DNA" /codon_start=1 /product="putative tyrosine protein phosphatase OCA1" /protein_id="DAA10446.1" /db_xref="SGD:S000005043" /translation="MTSKVGEYEDVPEDESRLTEENVSVPEEEVEDEDEEEDDDDDHI YINEETESGREKVLVSHAPQERIVPPLNFCPVERYLYRSGQPSPVNFPFLLNLKLKTI IWLSNEEPQDTLLEFCDTHRINLQFAAINPDAGEDDNPWDGLTEHSIINVLQTIVTQE NYPLLVCCGMGRHRTGTVIGCLRRIMGWNLASVSEEYRRFTGSRGGRILVELLIEAFD TNLVKIDKNKAPSWLLTALE" gene complement(439602..440570) /gene="RAS2" /locus_tag="YNL098C" /gene_synonym="CTN5" /gene_synonym="CYR3" /gene_synonym="GLC5" /gene_synonym="TSL7" mRNA complement(439602..440570) /gene="RAS2" /locus_tag="YNL098C" /gene_synonym="CTN5" /gene_synonym="CYR3" /gene_synonym="GLC5" /gene_synonym="TSL7" /product="Ras family GTPase RAS2" CDS complement(439602..440570) /gene="RAS2" /locus_tag="YNL098C" /gene_synonym="CTN5" /gene_synonym="CYR3" /gene_synonym="GLC5" /gene_synonym="TSL7" /EC_number="3.6.5.2" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:8106517]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:6438624]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23127800]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:22575457|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:22575457]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836|PMID:23127800|PMID:11914276|PMID:20162532]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0016236 macroautophagy [PMID:15016820]" /experiment="EXISTENCE:genetic interaction:GO:0097271 protein localization to bud neck [PMID:12782684]" /experiment="EXISTENCE:mutant phenotype:GO:0000411 positive regulation of transcription by galactose [PMID:16292676]" /experiment="EXISTENCE:mutant phenotype:GO:0010603 regulation of cytoplasmic mRNA processing body assembly [PMID:21925385]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:2558958]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:15016820]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:15917658]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:21925385]" /experiment="EXISTENCE:mutant phenotype:GO:2000222 positive regulation of pseudohyphal growth [PMID:1547504|PMID:8643578]" /note="GTP-binding protein; regulates nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; activated by increased levels of glycolysis intermediate fructose-1,6-bisphosphate; homolog of mammalian Ras proto-oncogenes; RAS2 has a paralog, RAS1, that arose from the whole genome duplication" /codon_start=1 /product="Ras family GTPase RAS2" /protein_id="DAA10447.1" /db_xref="SGD:S000005042" /translation="MPLNKSNIREYKLVVVGGGGVGKSALTIQLTQSHFVDEYDPTIE DSYRKQVVIDDEVSILDILDTAGQEEYSAMREQYMRNGEGFLLVYSITSKSSLDELMT YYQQILRVKDTDYVPIVVVGNKSDLENEKQVSYQDGLNMAKQMNAPFLETSAKQAINV EEAFYTLARLVRDEGGKYNKTLTENDNSKQTSQDTKGSGANSVPRNSGGHRKMSNAAN GKNVNSSTTVVNARNASIESKTGLAGNQATNGKTQTDRTNIDNSTGQAGQANAQSANT VNNRVNNNSKAGQVSNAKQARKQQAAPGGNTSEASKSGSGGCCIIS" gene complement(440797..440919) /gene="PLS1" /locus_tag="YNL097C-B" /gene_synonym="YNL097C-A" mRNA complement(440797..440919) /gene="PLS1" /locus_tag="YNL097C-B" /gene_synonym="YNL097C-A" /product="Pls1p" CDS complement(440797..440919) /gene="PLS1" /locus_tag="YNL097C-B" /gene_synonym="YNL097C-A" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:35563734]" /experiment="EXISTENCE:mutant phenotype:GO:1902986 regulation of lysine biosynthetic process via aminoadipic acid [PMID:35563734]" /note="Peroxisomal matrix protein that regulates lysine biosynthesis; localization to peroxisomes upon lysine deprivation is dependent on targeting factor Pex5p and lysine biosynthesis enzyme Lys1p; affects abundance of Lys1p and the lysine biosynthesis pathway" /codon_start=1 /product="Pls1p" /protein_id="DAA10448.1" /db_xref="SGD:S000028699" /translation="MTAKTKQSWNKGIWENGKQGSHQQTFLPKIWVNIYSTPTS" gene complement(441366..442358) /gene="PHO23" /locus_tag="YNL097C" mRNA complement(441366..442358) /gene="PHO23" /locus_tag="YNL097C" /product="Pho23p" CDS complement(441366..442358) /gene="PHO23" /locus_tag="YNL097C" /experiment="EXISTENCE:direct assay:GO:0000118 histone deacetylase complex [PMID:12672825]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:16286008|PMID:16286007|PMID:19040720|PMID:16314178]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:direct assay:GO:0140002 histone H3K4me3 reader activity [PMID:17142463]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:10805724]" /experiment="EXISTENCE:mutant phenotype:GO:0016479 negative regulation of transcription by RNA polymerase I [PMID:19270272]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:20398213]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17210643|PMID:20398213]" /experiment="EXISTENCE:mutant phenotype:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:16286008]" /experiment="EXISTENCE:mutant phenotype:GO:0061188 negative regulation of rDNA heterochromatin formation [PMID:16286008]" /experiment="EXISTENCE:mutant phenotype:GO:2000219 positive regulation of invasive growth in response to glucose limitation [PMID:18202364]" /note="Component of the Rpd3L histone deacetylase complex; involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus shares significant sequence identity with the human candidate tumor suppressor p33-ING1 and its isoform ING3" /codon_start=1 /product="Pho23p" /protein_id="DAA10449.1" /db_xref="SGD:S000005041" /translation="MSSPANLFPGLNDITDVLEEFPLATSRYLTLLHEIDAKCVHSMP NLNERIDKFLKKDFNKDHQTQVRLLNNINKIYEELMPSLEEKMHVSSIMLDNLDRLTS RLELAYEVAIKNTEIPRGLRLGVDNHPAMHLHHELMEKIESKSNSKSSQALKSESRRE AMAANRRQGEHYSASTHQQDDSKNDANYGGSRHESQDHTGNNTNSRKRANAANTNNAD PETKKRKRRVATTAVSPSTISTATAVNNGRIGTSTASRGVSSVGNSNNSRISRPKTND YGEPLYCYCNQVAYGEMVGCDGADCELEWFHLPCIGLETLPKGKWYCDDCKKKL" gene 443006..443119 /locus_tag="YNCN0007W" tRNA join(443006..443043,443076..443119) /locus_tag="YNCN0007W" /product="tRNA-Leu" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006645" gene complement(443398..444315) /gene="RPS7B" /locus_tag="YNL096C" mRNA complement(join(443398..443826,444172..444315)) /gene="RPS7B" /locus_tag="YNL096C" /product="40S ribosomal protein eS7 RPS7B" CDS complement(join(443398..443826,444172..444315)) /gene="RPS7B" /locus_tag="YNL096C" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:genetic interaction:GO:0042254 ribosome biogenesis [PMID:16246728]" /note="Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="40S ribosomal protein eS7 RPS7B" /protein_id="DAA10450.1" /db_xref="SGD:S000005040" /translation="MSSVQSKILSQAPSELELQVAKTFIDLESSSPELKADLRPLQIK SIREIDVTGGKKALVLFVPVPALSAYHKVQTKLTRELEKKFPDRHVIFLAERRILPKP SRTSRQVQKRPRSRTLTAVHDKVLEDMVFPTEIVGKRVRYLVGGNKIQKVLLDSKDVQ QIDYKLESFQAVYNKLTGKQIVFEIPSQTN" gene complement(444912..446840) /locus_tag="YNL095C" mRNA complement(444912..446840) /locus_tag="YNL095C" /product="hypothetical protein" CDS complement(444912..446840) /locus_tag="YNL095C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10451.1" /db_xref="SGD:S000005039" /translation="MVHITLGQAIWVSVKPIIKIYLIIGVGFLMAKMGILTVEATRII SDIVLTVLLPSLSFNKIVANIEDKDIKSVGIICLSALLIFGSGFFFAYVVRLFLPVPK QWYGGILAGGMFPNISDLPIAYLQSMDQGLVFSEEEGNKGVANVIIFLTMFLICIFNL GGFRLIESDFEYNDDESAVRVSETTKTQPAVSANTTNTDTSERFFSNEQQLFNNKYTA RDSLTEAIGTKGENADVPPISRRSTNSIAPLSLPDTSSNSKITKPVQVKARNTIACTQ SEESQATRGSNPLDSQSSASTIHSYNTSESYESSIDTMRARRTASQPRAYNTTTLLEE NCLDEKCPKNMSMAALEPIRSIDMRALPSQNIHHLIREYSNVDQYGHQRRNSSLRGAD MNDVHSISSNSTLQTIKTANLTRILTSDATVSKKDIETSGESLPQWMRKFSLTPLLVF FLKNCLRPCSMAVIIALTVAFIPWVKALFVTTANTPHISQAPDNAPPLSFFMDFTGYV GAACVPFGLILLGATLGRLKIGNLYPGFWKAAVTLVILRQCVMPIFGVLWCDRLVKAG WVNWQDDRMLLFVIAISWNLPTMTTLIYFTASFTPPETTAPIQMECVSFFLMLQYPLM VVSLPFLVSYFLKVQMNL" gene 447611..449374 /gene="APP1" /locus_tag="YNL094W" mRNA 447611..449374 /gene="APP1" /locus_tag="YNL094W" /product="phosphatidate phosphatase APP1" CDS 447611..449374 /gene="APP1" /locus_tag="YNL094W" /EC_number="3.1.3.4" /experiment="EXISTENCE:direct assay:GO:0008195 phosphatidate phosphatase activity [PMID:23071111|PMID:23335564]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:11489916]" /experiment="EXISTENCE:mutant phenotype:GO:0006629 lipid metabolic process [PMID:23071111]" /experiment="EXISTENCE:mutant phenotype:GO:0008195 phosphatidate phosphatase activity [PMID:23071111]" /note="Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway" /codon_start=1 /product="phosphatidate phosphatase APP1" /protein_id="DAA10452.1" /db_xref="SGD:S000005038" /translation="MNSQGYDESSSSTAATSGPTSGDPRMGKKQRFMNLIRTTKDVYI PNLTSSISQKTMDGIRSTTNSFEGYNDLPMELPHNTTITYFPTYTTTNLVDPDGLSAP RKDFETTVRCAVSYPGNPTSRRNRWLLSLCKQYLRTGTAEADVAPVVPPHLEEDSGDL NDSQSSIESSLSSKSENRYSHMGIQEEDVLNERIQGFLSKKVPNTPVVVDLLPKDKLR GDTASFFGTTDSYGNLLIKAETDFLPSKINITLDTPIEGHADPISETFPANYVSPYGI GLISDIDDTIKHTGVTGDRRSMFRNVFIHDVQSWVIDGVPLWYKTLHDVADVDFFYVS NSPIQTFTLLKQYICANFPPGPIFLKQYSGNFFSTIMTSSANRKIQPIANILKDFPKK KFILVGDSGEHDLEAYTTTALQFPNQILAIYIRCCSNSMSDVPSHDEEVMNEVNNIIE LQQRPMQMTKSTVRTRRRPPPPPIPSTQKPSLTEEQTESIRMSRRNKDENNAKRVAPP PLPNRQLPNLDANTYYVPSSQNDYGMYGAFMDKKADEWKRRVMDSIQKLSNQDTTLMF FSDPALSLEDSIRRIREKYSN" rep_origin 449429..449588 /note="ARS1419; Autonomously Replicating Sequence" /db_xref="SGD:S000118387" gene 449868..450530 /gene="YPT53" /locus_tag="YNL093W" mRNA 449868..450530 /gene="YPT53" /locus_tag="YNL093W" /product="Rab family GTPase YPT53" CDS 449868..450530 /gene="YPT53" /locus_tag="YNL093W" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11210571]" /experiment="EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:22748138]" /experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:8163546]" /experiment="EXISTENCE:mutant phenotype:GO:0005770 late endosome [PMID:11872141]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:8163546]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8163546]" /note="Stress-induced Rab family GTPase; required for vacuolar protein sorting and endocytosis; involved in ionic stress tolerance; similar to Vps21p and Ypt52p; functional homolog of Vps21p; mammalian Rab5 homolog; YPT53 has a paralog, VPS21, that arose from the whole genome duplication" /codon_start=1 /product="Rab family GTPase YPT53" /protein_id="DAA10453.1" /db_xref="SGD:S000005037" /translation="MDKHTAAIPTLTIKVVLLGESAVGKSSIVLRFVSDDFKESKEPT IGAAFLTKRITRDGKVIKFEIWDTAGQERFAPLAPMYYRNAQAALVVFDVTNEGSFYK AQNWVEELHEKVGHDIVIALVGNKMDLLNNDDENENRAMKAPAVQNLCERENLLYFEA SAKTGENIYQIFQTLGEKVPCPEQNTRQSSTHDRTITDNQRIDLESTTVESTRETGGC NC" gene 450871..452073 /locus_tag="YNL092W" mRNA 450871..452073 /locus_tag="YNL092W" /product="S-adenosylmethionine-dependent methyltransferase" CDS 450871..452073 /locus_tag="YNL092W" /EC_number="2.1.1.22" /experiment="EXISTENCE:direct assay:GO:0006479 protein methylation [PMID:24651469]" /experiment="EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:24651469]" /note="S-adenosylmethionine-dependent protein methyltransferase; capable of automethylation; member of the seven beta-strand family; YNL092W is not an essential gene" /codon_start=1 /product="S-adenosylmethionine-dependent methyltransferase" /protein_id="DAA10454.1" /db_xref="SGD:S000005036" /translation="MDENEFDNQRENKAVARVIISFLKYEEYALKEIYNLRVKKWASI SDRQKDMVPNYTKYLANLKAAIIENGKFFRSVAEYALQSISFEPGEIVQPNDLDMSKT CSLLTQVYREWSAEAISERNCLNSRLVPFLKTLSPPKADILIPGCGTGRLLVDLSRMG YNCEGNEFSYHMLLVSQYMLNAGLLQNQIIIYPFIHCFSHWKKIEDQLSPIKVPDIEA WSSNKGMGSMSICAGSFVDCYGRNQGTKISSHYTFSRRMQLSRAKAENSKDVVVTNFF IDTGSNILDYLDTIGHVLKPGGIWCNFGPLLYHFENDHGVETTYEVNPYSGFQDKIND YTPLMGLELSSDDIISIATNHLDFELIRRESGILCGYGRYAGPESCAMPGYMCHYWIL KSNPTNES" gene 452408..456130 /gene="NST1" /locus_tag="YNL091W" mRNA 452408..456130 /gene="NST1" /locus_tag="YNL091W" /product="Nst1p" CDS 452408..456130 /gene="NST1" /locus_tag="YNL091W" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:34347506]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0017148 negative regulation of translation [PMID:34347506]" /experiment="EXISTENCE:mutant phenotype:GO:0009651 response to salt stress [PMID:11816027]" /note="Translational inhibitor and suppressor of proteasome-assembly defects; P-body component that inhibits translation, rescues proteasome base assembly defects and aggregation of regulatory particle subunits during stress when overexpressed; proposed to function to bridge the HOG and pheromone pathways with the cell wall integrity pathway in response to heat stress; interacts physically and genetically with splicing factor MSL1; large, highly-charge protein containing many disordered regions" /codon_start=1 /product="Nst1p" /protein_id="DAA10455.1" /db_xref="SGD:S000005035" /translation="MPPNSKSKRRKNKSKQHNKKNGNSDPEQSINPTQLVPRMEPELY HTESDYPTSRVIKRAPNGDVIVEPINTDDDKKERTANLTHNKDSMDSASSLAFTLDSH WESLSPEEKKTILRIEKEEVFNVIRNYQDDHSCSCSVCGRRHLAMDQEMERIYNTLYA MDKDKDPETNPIKFHLGIIKELQISKNQQQNDLSSTKGEVVKNFLSSSTVGSLKEEVL HFKQKQLSKQEQAHNETADNTSLLEENLNNIHINKTSSEISANFNSVSDEELQQKYSN FTKTFISSHPKIAEEYVQKMMMYPNIRALTDDLMNSNGQGFLNAIEDFVRDGQIQASK KDDSITEDEASSTDLTDPKEFTTMLHSGKPLTEDEYADLQRNIAERMTNAYDTASKKF KDVSQLEKELFTRFMSGRDKKSFRELIIQSFKNKFDGELGPSVLAATLSSCFSSQSKD TSLDTDSIYEDEDEEDYDDYSEYAEDSEEVSEYEGIEAVEKPEHDEKSNGIRETLHLS YDHDHKRQNHPHHHYHSTSTHSEDELSEEEYISDIELPHDPHKHFHRDDDILDGDEDE PEEEDENEGDDEEDTYDSGLDETDRLEEGRKLIQIAITKLLQSRIMASYHEKQADNNR LKLLQELEEEKRKKREKEEKKQKKREKEKEKKRLQQLAKEEEKRKREEEKERLKKELE EREMRRREAQRKKVEEAKRKKDEERKRRLEEQQRREEMQEKQRKQKEELKRKREEEKK RIREQKRLEQEKLQKEKEEEERQRLIAEDALRKQKLNEEQTSANILSAKPFTENGVGN PVSSQSHPNMTNYQEDNSCSINDEILKMVNSVAASKPVSPTGFNVHDLLLPSTNNQMP AMEQSHLPQPGNQNNHFGTTTIPNALDLATKSSLQTENNYLMNSQTLENTSLLMHNNS SPTKLLPNDFGLSSWGGLTNTMSINPTCKPPVIQTSEMESQAHKSSPQATMPSFGLPN GGTHRKSFTDELNTLTSMLSSSGFADTSLSSSGFPPSQRSVWNDQKSSFSGPSTAGNF NNSSIQSGMLLAPTLGSVESFPNRTSIWDSSTTPMMNKSELSGRNITSTAQDSPAFMA SNIWSSNSQYNSPYLTSNVLQSPQISSGVDESHILDSIYNTYLAISPQDSLNPYIAIG TLFQNLVGLNLDYSTFINKLISMQGAYNCEFFTDNNGSITHVRFARQTPAGHSKGLLN QLFSGLNDPTATPFTSRPHTSTRASFPIASSTTQTS" gene 456565..457143 /gene="RHO2" /locus_tag="YNL090W" mRNA 456565..457143 /gene="RHO2" /locus_tag="YNL090W" /product="Rho family GTPase RHO2" CDS 456565..457143 /gene="RHO2" /locus_tag="YNL090W" /EC_number="3.6.5.2" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:10526184|PMID:11591390]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:18417612]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity and in microtubule assembly" /codon_start=1 /product="Rho family GTPase RHO2" /protein_id="DAA10456.1" /db_xref="SGD:S000005034" /translation="MSEKAVRRKLVIIGDGACGKTSLLYVFTLGKFPEQYHPTVFENY VTDCRVDGIKVSLTLWDTAGQEEYERLRPFSYSKADIILIGFAVDNFESLINARTKWA DEALRYCPDAPIVLVGLKKDLRQEAHFKENATDEMVPIEDAKQVARAIGAKKYMECSA LTGEGVDDVFEVATRTSLLMKKEPGANCCIIL" gene 457704..461990 /gene="TOP2" /locus_tag="YNL088W" /gene_synonym="TOR3" /gene_synonym="TRF3" mRNA 457704..461990 /gene="TOP2" /locus_tag="YNL088W" /gene_synonym="TOR3" /gene_synonym="TRF3" /product="DNA topoisomerase 2" CDS 457704..461990 /gene="TOP2" /locus_tag="YNL088W" /gene_synonym="TOR3" /gene_synonym="TRF3" /EC_number="5.6.2.2" /experiment="EXISTENCE:direct assay:GO:0000795 synaptonemal complex [PMID:1315786]" /experiment="EXISTENCE:direct assay:GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [PMID:6323017|PMID:6088500]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:6088500|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:6088500]" /experiment="EXISTENCE:direct assay:GO:0097047 DNA replication termination region [PMID:20797631]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:25430478]" /experiment="EXISTENCE:genetic interaction:GO:0009303 rRNA transcription [PMID:2436053]" /experiment="EXISTENCE:mutant phenotype:GO:0000019 regulation of mitotic recombination [PMID:2902925]" /experiment="EXISTENCE:mutant phenotype:GO:0006265 DNA topological change [PMID:31969709]" /experiment="EXISTENCE:mutant phenotype:GO:0006271 DNA strand elongation involved in DNA replication [PMID:2549254]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:9199287]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:2156624]" /experiment="EXISTENCE:mutant phenotype:GO:0031055 chromatin remodeling at centromere [PMID:18701701]" /experiment="EXISTENCE:mutant phenotype:GO:0097046 replication fork progression beyond termination site [PMID:20797631]" /note="Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; human homolog TOP2A implicated in cancers, and can complement yeast null mutant" /codon_start=1 /product="DNA topoisomerase 2" /protein_id="DAA10457.1" /db_xref="SGD:S000005032" /translation="MSTEPVSASDKYQKISQLEHILKRPDTYIGSVETQEQLQWIYDE ETDCMIEKNVTIVPGLFKIFDEILVNAADNKVRDPSMKRIDVNIHAEEHTIEVKNDGK GIPIEIHNKENIYIPEMIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILET ADLNVGQKYVQKWENNMSICHPPKITSYKKGPSYTKVTFKPDLTRFGMKELDNDILGV MRRRVYDINGSVRDINVYLNGKSLKIRNFKNYVELYLKSLEKKRQLDNGEDGAAKSDI PTILYERINNRWEVAFAVSDISFQQISFVNSIATTMGGTHVNYITDQIVKKISEILKK KKKKSVKSFQIKNNMFIFINCLIENPAFTSQTKEQLTTRVKDFGSRCEIPLEYINKIM KTDLATRMFEIADANEENALKKSDGTRKSRITNYPKLEDANKAGTKEGYKCTLVLTEG DSALSLAVAGLAVVGRDYYGCYPLRGKMLNVREASADQILKNAEIQAIKKIMGLQHRK KYEDTKSLRYGHLMIMTDQDHDGSHIKGLIINFLESSFPGLLDIQGFLLEFITPIIKV SITKPTKNTIAFYNMPDYEKWREEESHKFTWKQKYYKGLGTSLAQEVREYFSNLDRHL KIFHSLQGNDKDYIDLAFSKKKADDRKEWLRQYEPGTVLDPTLKEIPISDFINKELIL FSLADNIRSIPNVLDGFKPGQRKVLYGCFKKNLKSELKVAQLAPYVSECTAYHHGEQS LAQTIIGLAQNFVGSNNIYLLLPNGAFGTRATGGKDAAAARYIYTELNKLTRKIFHPA DDPLYKYIQEDEKTVEPEWYLPILPMILVNGAEGIGTGWSTYIPPFNPLEIIKNIRHL MNDEELEQMHPWFRGWTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKE YLLLGLSGNDKIKPWIKDMEEQHDDNIKFIITLSPEEMAKTRKIGFYERFKLISPISL MNMVAFDPHGKIKKYNSVNEILSEFYYVRLEYYQKRKDHMSERLQWEVEKYSFQVKFI KMIIEKELTVTNKPRNAIIQELENLGFPRFNKEGKPYYGSPNDEIAEQINDVKGATSD EEDEESSHEDTENVINGPEELYGTYEYLLGMRIWSLTKERYQKLLKQKQEKETELENL LKLSAKDIWNTDLKAFEVGYQEFLQRDAEARGGNVPNKGSKTKGKGKRKLVDDEDYDP SKKNKKSTARKGKKIKLEDKNFERILLEQKLVTKSKAPTKIKKEKTPSVSETKTEEEE NAPSSTSSSSIFDIKKEDKDEGELSKISNKFKKISTIFDKMGSTSATSKENTPEQDDV ATKKNQTTAKKTAVKPKLAKKPVRKQQKVVELSGESDLEILDSYTDREDSNKDEDDAI PQRSRRQRSSRAASVPKKSYVETLELSDDSFIEDDEEENQGSDVSFNEED" gene 462411..465947 /gene="TCB2" /locus_tag="YNL087W" mRNA 462411..465947 /gene="TCB2" /locus_tag="YNL087W" /product="tricalbin" CDS 462411..465947 /gene="TCB2" /locus_tag="YNL087W" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:13679573]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:22250200]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:22250200]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0055091 phospholipid homeostasis [PMID:35440494]" /experiment="EXISTENCE:genetic interaction:GO:0060304 regulation of phosphatidylinositol dephosphorylation [PMID:23237950]" /experiment="EXISTENCE:genetic interaction:GO:0090158 endoplasmic reticulum membrane organization [PMID:23237950]" /experiment="EXISTENCE:mutant phenotype:GO:0035621 ER to Golgi ceramide transport [PMID:33205016]" /note="Lipid-binding ER tricalbin involved in ER-plasma membrane tethering; one of at least 7 proteins (Ice2p, Ist2p, Scs2/Scs22p, Tcb1-Tcb3p) that affect cER tethering and contact with the plasma membrane (PM); regulates PI4P levels by controlling access of Sac1p to its substrate PI4P in the PM; regulates PM phospholipid homeostasis; contains 3 calcium and lipid binding domains; localizes to the cortical ER, the cell periphery and is enriched in bud membranes; mRNA is targeted to the bud tip" /codon_start=1 /product="tricalbin" /protein_id="DAA10458.1" /db_xref="SGD:S000005031" /translation="MSPNSSKTRTDQISSMPGINEATKVESKNVVKDAVPIKSEVETN GTSIVREKQDPSYVGWKQVGGWEEKDELTSEDLLVDVNKDTFLGNLLPDKFYGDWYHE VAILIIAGLCSFVLGYFKFSLASVLIVMLTTGMLYRTSSKKYRESLRDLAQKEQTVEK ITSDYESVEWLNTFLDKYWPIIEPSVSQQIVDGTNTALSENVAIPKFIKAIWLDQFTL GVKPPRIDAIKTFQNTKSDVVVMDVCLSFTPHDMSDLDAKQCRNYVNSNVVLKAKIFG MDIPVSVADIFFQVFVRFRFQLMTTLPLVETINIQLLEVPEVDFISRLLGNSVFNWEI LAIPGLMRLIQKMAFKYLSPVLLPPFSLQLNIPQLLSKTGLPIGVLEIKVKNAHGLRK LVGMIKKTVDPYLTFELSGKIVGKTKVFKNSANPVWNESIYILLQSFTDPLTIAVYDK RETLSDKKMGTVIFNLNKLHANHYHKNEKVHFLRNSKPVGELTFDLRFFPTIEPKKLL NGDEEPLPDMNTGITKITIRELKGLDELSDKKFVFAELYVNAELVMTTKKEKRTAHLK WNSDYYSVVTDRRKTICRFVLKDQSGKVISSSVQPLNHLIDRTEVNKEWIPLRNGKGE LKVTTYWRPVDIDLGLKSVGYTTPIGMLRVFINKAENLRNPDSLGKISPYAKVSVNGV ARGRTNERIETLNPIWNQSIYVSVTSPLQKVSIDCFGIDTNGDDHNLGSLNIQTQNIY HKDNDDKYTIFIDNAPRTGNLIGKKGVKGTVTYYLSFYPVVPVLSLEEAKEVDEINEK KDKLEKQKSTLDDKNISKEEKERIKKEEFRLTEKYDMYSYKMKLDLDELLQYNAGVLG VTVLGGELPQPGLYVQTFFDSCGYAAITSAKNAIRTIKTGWSGDFMIKELEWSVTTFR VTKTKDANKAENFICEVNIPTIELVRNCYYKPSVLNLIGKKSAKLLVQVSWFPVTATE LPQSDLITNSGDLKITAKSAENLIGVNKNGYSDPYVEFFLNEKSTSPFFKTAVQKKTL NPTWNESKTIEVSNRVNDYLTINVKDYESTNSNRSIGKAVVPLSTIDPESDTTFNIPL VGPKGEDGGVLHLEFEFEPRYTTNVVKREAGLGNFATKGLGTGIKAGSTVFALGTNVV STGLGTIDKVKAGVFGGKKSTTTGDKKSEEKQ" gene 466334..466642 /gene="SNN1" /locus_tag="YNL086W" mRNA 466334..466642 /gene="SNN1" /locus_tag="YNL086W" /product="Snn1p" CDS 466334..466642 /gene="SNN1" /locus_tag="YNL086W" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031083 BLOC-1 complex [PMID:23547030]" /experiment="EXISTENCE:mutant phenotype:GO:0007032 endosome organization [PMID:23547030]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:23547030]" /note="Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; green fluorescent protein (GFP)-fusion protein localizes to endosomes" /codon_start=1 /product="Snn1p" /protein_id="DAA10459.1" /db_xref="SGD:S000005030" /translation="MAGDSISADGTGVHPVELSVYSVLSTDLDGLYQSINELRESQAL LILMLRKVRDKLRREGQVLYDPEPFKPTMDKLADLSARVRILSQRYEELQGNARALNN " gene 467131..469623 /gene="MKT1" /locus_tag="YNL085W" mRNA 467131..469623 /gene="MKT1" /locus_tag="YNL085W" /product="Mkt1p" CDS 467131..469623 /gene="MKT1" /locus_tag="YNL085W" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:24970865]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:18617998]" /note="Putative nuclease that forms a complex with Pbp1p; involved in posttranscriptional regulation of HO, propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, stress responses through posttranscriptional modulation of Puf3p targets; forms cytoplasmic foci upon DNA replication stress; localization to P-bodies under ethanol stress differs between strains" /codon_start=1 /product="Mkt1p" /protein_id="DAA10460.1" /db_xref="SGD:S000005029" /translation="MAIKSLESFLFERGLVGSYAIEALNNCTLDIDVNHYVSRLLTNK REQYLDAIGGFPTSLKMYLESDLKIFKDFNITPIFVFNGGLTYNQLEASGHFTAASAS ASISSTTTSSSGTNATTRSNTESVLLQRSRGWTQWNNLISSNQNSYIDQPIQPQEPFR HNTTIDSKAYQNDLIAYFIEHGYMYQVAPYSSWFQLAYLLNSAYIDAIYGPTDCLMLD CVDRFILGMEFPNKEFRFIDRSRVMKDLGCTHEEFIDIAMAVGNDLQPTTLPPLQIYP VPQLFDIALEMVLNTGTNFYAYQLSTTLQNDSKENIQNYQRGISALRYMPVLKDTGKV ELFVQEIVVSEEDSEKNNKDGKKSNLSSPSSASSSASPATTVTKNASEKLTYEKSSTK EVRKPRDIPNDVHDFIGQMLPHEYYFYRSIGLVTGKLFDAIVTGVYPEEPPLGGGSST SYKKLVSKSVEIFKNKEINLLTQPINRYYQIKQIKQVKWYAANEPTTLTNRMSPSMFE TINHLIVKTETSDEKEFSISEFITTINGSSNMAKDFISEKVIFPNSVPIESKLNSPFN LLSTNFLRLLVLLEFFTFDFKEKLLEPTRWGEVFLKLNELNIDSKYHESVIIFLVFLK CDVLKLDEEVQPPAPSALSQATLRSYPEESLYVLLITRVLTLFQVDQKPSNYHGPIDK KTLIFRDHLSFIKENLNELFEAVLISSLTSGEFNRLSLDNFGWARKIVRYLPFKLDSP NTIMAMMWEFFLQKYLHNGNAKNDALSLVATEFNTYKSTPNLDEQFVESHRFLLEISK VMQELNAAKLIDENVFKLFTKAVEFTTTALSS" gene complement(470053..471102) /gene="END3" /locus_tag="YNL084C" mRNA complement(470053..471102) /gene="END3" /locus_tag="YNL084C" /product="End3p" CDS complement(470053..471102) /gene="END3" /locus_tag="YNL084C" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:1990964 actin cytoskeleton-regulatory complex [PMID:17151356|PMID:10594004]" /experiment="EXISTENCE:genetic interaction:GO:0009267 cellular response to starvation [PMID:35101986]" /experiment="EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:35101986]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8380177]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15944351]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:10594004]" /experiment="EXISTENCE:physical interaction:GO:1990964 actin cytoskeleton-regulatory complex [PMID:17151356]" /note="EH domain-containing protein involved in endocytosis; actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p" /codon_start=1 /product="End3p" /protein_id="DAA10461.1" /db_xref="SGD:S000005028" /translation="MPKLEQFEIKKYWQIFSGLKPIENKVNHDQVLPILYNSKLDSSV LNKIWFLADIDDDDNLDFEEFVICMRLIFDMVNKNISSVPDELPDWLIPGSKVNLIKE RKKRKQIENADLPPKKEIKVDWYMSPDDLNQYEKIYNSCAKLTDGTITFNELSTKLST KFFNISKTDLNKVWSLINPQNLPSIDRDPTFYFIHCLRQRNDLGAEIPASLPNSLAEV CNKKQLSYDLRSSQPPTKRKEEANEVDNLRDNGQNSSSDSSGSNVLSNEDSIKQKYAS LTDDQVANMREQLEGLLNYKKSEKTQGGSKLSKRINIRSITDDLDNIEQQVEVLENYL NNKRHELQALQAEIN" gene 471377..472861 /gene="SAL1" /locus_tag="YNL083W" mRNA 471377..472861 /gene="SAL1" /locus_tag="YNL083W" /product="Ca(2+)-binding ATP:ADP antiporter SAL1" CDS 471377..472861 /gene="SAL1" /locus_tag="YNL083W" /experiment="EXISTENCE:direct assay:GO:0005509 calcium ion binding [PMID:15238515]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0005471 ATP:ADP antiporter activity [PMID:18485069]" /experiment="EXISTENCE:mutant phenotype:GO:0006839 mitochondrial transport [PMID:18485069]" /experiment="EXISTENCE:mutant phenotype:GO:0015866 ADP transport [PMID:18485069]" /experiment="EXISTENCE:mutant phenotype:GO:0015867 ATP transport [PMID:18485069]" /note="ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains" /codon_start=1 /product="Ca(2+)-binding ATP:ADP antiporter SAL1" /protein_id="DAA10462.2" /db_xref="SGD:S000005027" /translation="MLLKNCETDKQRDIRYACLFKELDVKGNGQVTLDNLISAFEKND HPLKGNDEAIKMLFTAMDVNKDSVVDLSDFKKYASNAESQIWNGFQRIDLDHDGKIGI NEINRYLSDLDNQSICNNELNHELSNEKMNKFSRFFEWAFPKRKANIALRGQASHKKN TDNDRSKKTTDSDLYVTYDQWRDFLLLVPRKQGSRLHTAYSYFYLFNEDVDLSSEGDV TLINDFIRGFGFFIAGGISGVISRTCTAPFDRLKVFLIARTDLSSILLNSKTDLLAKN PNADINKISSPLAKAVKSLYRQGGIKAFYVGNGLNVIKVFPESSIKFGSFEVTKKIMT KLEGCRDTKDLSKFSTYIAGGLAGMAAQFSVYPIDTLKFRVQCAPLDTKLKGNNLLFQ TAKDMFREGGGQIILQRCHSRYSGHISLCCIRFGDFFCLKKMVYCQTGKDPEPTTRSG HSKQPGCTSNGCIQWNCRSFCCLSNQSFKNKTTSPRNICTSLCV" gene 473391..476012 /gene="PMS1" /locus_tag="YNL082W" mRNA 473391..476012 /gene="PMS1" /locus_tag="YNL082W" /product="ATP-binding mismatch repair protein" CDS 473391..476012 /gene="PMS1" /locus_tag="YNL082W" /experiment="EXISTENCE:direct assay:GO:0000404 heteroduplex DNA loop binding [PMID:9368761]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:11575920]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:11575920]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:11717305]" /experiment="EXISTENCE:direct assay:GO:0032135 DNA insertion or deletion binding [PMID:9368761]" /experiment="EXISTENCE:direct assay:GO:0032139 dinucleotide insertion or deletion binding [PMID:9368761]" /experiment="EXISTENCE:mutant phenotype:GO:0000710 meiotic mismatch repair [PMID:16702432]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:10938116]" /experiment="EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:2685551]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:11717305]" /experiment="EXISTENCE:physical interaction:GO:0032389 MutLalpha complex [PMID:8066446|PMID:10570173|PMID:11237696]" /note="ATP-binding protein required for mismatch repair; required for both mitosis and meiosis; functions as a heterodimer with Mlh1p; binds double- and single-stranded DNA via its N-terminal domain; required for silencing at the silent mating-type loci and telomeres; similar to E. coli MutL" /codon_start=1 /product="ATP-binding mismatch repair protein" /protein_id="DAA10463.1" /db_xref="SGD:S000005026" /translation="MTQIHQINDIDVHRITSGQVITDLTTAVKELVDNSIDANANQIE IIFKDYGLESIECSDNGDGIDPSNYEFLALKHYTSKIAKFQDVAKVQTLGFRGEALSS LCGIAKLSVITTTSPPKADKLEYDMVGHITSKTTTSRNKGTTVLVSQLFHNLPVRQKE FSKTFKRQFTKCLTVIQGYAIINAAIKFSVWNITPKGKKNLILSTMRNSSMRKNISSV FGAGGMRGLEEVDLVLDLNPFKNRMLGKYTDDPDFLDLDYKIRVKGYISQNSFGCGRN SKDRQFIYVNKRPVEYSTLLKCCNEVYKTFNNVQFPAVFLNLELPMSLIDVNVTPDKR VILLHNERAVIDIFKTTLSDYYNRQELALPKRMCSQSEQQAQKRLKTEVFDDRSTTHE SDNENYHTARSESNQSNHAHFNSTTGVIDKSNGTELTSVMDGNYTNVTDVIGSECEVS VDSSVVLDEGNSSTPTKKLPSIKTDSQNLSDLNLNNFSNPEFQNITSPDKARSLEKVV EEPVYFDIDGEKFQEKAVLSQADGLVFVDNECHEHTNDCCHQERRGSTDTEQDDEADS IYAEIEPVEINVRTPLKNSRKSISKDNYRSLSDGLTHRKFEDEILEYNLSTKNFKEIS KNGKQMSSIISKRKSEAQENIIKNKDELEDFEQGEKYLTLTVSKNDFKKMEVVGQFNL GFIIVTRKVDNKYDLFIVDQHASDEKYNFETLQAVTVFKSQKLIIPQPVELSVIDELV VLDNLPVFEKNGFKLKIDEEEEFGSRVKLLSLPTSKQTLFDLGDFNELIHLIKEDGGL RRDNIRCSKIRSMFAMRACRSSIMIGKPLNKKTMTRVVHNLSELDKPWNCPHGRPTMR HLMELRDWSSFSKDYEI" gene complement(476188..476619) /gene="SWS2" /locus_tag="YNL081C" /gene_synonym="uS13m" mRNA complement(476188..476619) /gene="SWS2" /locus_tag="YNL081C" /gene_synonym="uS13m" /product="putative mitochondrial 37S ribosomal protein SWS2" CDS complement(476188..476619) /gene="SWS2" /locus_tag="YNL081C" /gene_synonym="uS13m" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:28154081|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:28154081]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:28154081]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /note="Component of mitochondrial small ribosomal subunit; similar to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency; localizes to vacuole in response to H2O2; localizes to peroxisomes in glucose-growing cells" /codon_start=1 /product="mitochondrial 37S ribosomal protein uS13m SWS2" /protein_id="DAA10464.1" /db_xref="SGD:S000005025" /translation="MVVHILGKGFKGKEVIKIALASKFYGIGKTTAEKICSKLGFYPW MRMHQLSEPQIMSIASELSTMTIEGDARAIVKDNIALKRKIGSYSGMRHTLHLPVRGQ HTRNNAKTARKLNKIDRRGIHTFSQAKVQHNPSLWSCIFGK" gene complement(476932..478032) /gene="EOS1" /locus_tag="YNL080C" mRNA complement(476932..478032) /gene="EOS1" /locus_tag="YNL080C" /product="Eos1p" CDS complement(476932..478032) /gene="EOS1" /locus_tag="YNL080C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:17187761]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:17187761]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:17187761]" /note="Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene" /codon_start=1 /product="Eos1p" /protein_id="DAA10465.1" /db_xref="SGD:S000005024" /translation="MTWILSTGMGPHEDKYAKHERATFKKTYSSMKTLSLNHLTAKQH MLMALCRDISLLPPLTYIFTSLRKAWRVSMRTSITLYEPQSLRDAFTYFWQKLNSAYD NNSSFEGASQKAVNGDGKDSLLLSALTTARASEYLLCSLWCLVSLYLSYAILDSLMVR WIVKYSTVAAILRMFSMSLIIVTLELLLLSSLSPELDYFLHTWILISCVLTAVYIWQS YLTSDLRYIRNQEGEVQEDTNVPEETEDYEDGEDDADEDSHVVVADESTVDVPSNDSL SDNSDGGLFPVNRPSVSHSQSPKRPKKYPKKAFNFTTKRTIDLYKITVLCVVPVGLAS FITMLGLLRNLFIQRLDVEQLERILHEMHPPA" gene complement(478566..479165) /gene="TPM1" /locus_tag="YNL079C" mRNA complement(478566..479165) /gene="TPM1" /locus_tag="YNL079C" /product="tropomyosin TPM1" CDS complement(478566..479165) /gene="TPM1" /locus_tag="YNL079C" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:9864365]" /experiment="EXISTENCE:direct assay:GO:0003786 actin lateral binding [PMID:11457840]" /experiment="EXISTENCE:direct assay:GO:0005884 actin filament [PMID:7844152]" /experiment="EXISTENCE:direct assay:GO:0032432 actin filament bundle [PMID:2649250|PMID:9864365]" /experiment="EXISTENCE:genetic interaction:GO:0051017 actin filament bundle assembly [PMID:9864365]" /experiment="EXISTENCE:genetic interaction:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:12419188]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:7844152|PMID:2649250|PMID:17237521]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9055077]" /experiment="EXISTENCE:mutant phenotype:GO:0030447 filamentous growth [PMID:15645503]" /experiment="EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:17237521]" /note="Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication" /codon_start=1 /product="tropomyosin TPM1" /protein_id="DAA10466.1" /db_xref="SGD:S000005023" /translation="MDKIREKLSNLKLEAESWQEKYEELKEKNKDLEQENVEKENQIK SLTVKNQQLEDEIEKLEAGLSDSKQTEQDNVEKENQIKSLTVKNHQLEEEIEKLEAEL AESKQLSEDSHHLQSNNDNFSKKNQQLEEDLEESDTKLKETTEKLRESDLKADQLERR VAALEEQREEWERKNEELTVKYEDAKKELDEIAASLENL" gene 479768..480991 /gene="NIS1" /locus_tag="YNL078W" /gene_synonym="JIP1" mRNA 479768..480991 /gene="NIS1" /locus_tag="YNL078W" /gene_synonym="JIP1" /product="Nis1p" CDS 479768..480991 /gene="NIS1" /locus_tag="YNL078W" /gene_synonym="JIP1" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:25416945|PMID:30341817]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11817649]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:27385335|PMID:11817649]" /experiment="EXISTENCE:direct assay:GO:0032153 cell division site [PMID:25416945]" /experiment="EXISTENCE:direct assay:GO:0032174 cellular bud neck septin collar [PMID:30341817]" /experiment="EXISTENCE:direct assay:GO:0032177 cellular bud neck split septin rings [PMID:30341817]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:30341817]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:29074565]" /experiment="EXISTENCE:mutant phenotype:GO:0045184 establishment of protein localization [PMID:29074565]" /experiment="EXISTENCE:physical interaction:GO:0140014 mitotic nuclear division [PMID:11817649]" /note="Protein involved in axial bud site selection; prevents repolarization of cells at previous division sites; recruited with Nba1p to the cell cortex and to cytokinesis remnants (bud scars) by Aim44p and Nap1p where Nba1p prevents Rsr1p-mediated activation of Cdc24p, and therefore Cdc42p activation; acts with Nba1p to establish transient bud scar localization of Rga1p, a Cdc42p GAP; localizes to the nucleus and to cell division site during G2/M, and is then stably recruited to cytokinesis remnants" /codon_start=1 /product="Nis1p" /protein_id="DAA10467.1" /db_xref="SGD:S000005022" /translation="METYETSIGTQSYPPTLFPPPLGTGGFTTSGYIHALVDSTSNSN SNSNTNSNTNSNTNSNSDTKIPIVQISDDSHITHDSFKPYMEYHDASHLRNRNISKAD QVESTEVMEQFTQWSNYKMRSRSPTINAKPIRHTSQRRTDFTSKNELSKFSKNHNFIF HKGFLKRQHSIRREDRQAKVRSRFRSKKELTSVLNYIELEQMDIANVLASQPVNLHAI RNLTSRDPAVTPIPFLRSQMYATSSRPPYLRNRSISRKLPKSQPGSLPTTMPATATKT IKQNSTTPTTRSVYNKNVGRSNTSPSVLYHPKRRGKLNTKSHARKEQLLLELWREYLM LVITQRTQLRLTLLCSPGSASNESSVCSSNASDLDMSLLSTPSSLFQMAGETKSNPII IPDSQDDSILSSDPF" gene 481391..482977 /gene="APJ1" /locus_tag="YNL077W" mRNA 481391..482977 /gene="APJ1" /locus_tag="YNL077W" /product="Apj1p" CDS 481391..482977 /gene="APJ1" /locus_tag="YNL077W" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:23329686]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:direct assay:GO:0042405 nuclear inclusion body [PMID:32492414]" /experiment="EXISTENCE:genetic interaction:GO:0016925 protein sumoylation [PMID:23329686]" /experiment="EXISTENCE:mutant phenotype:GO:0043335 protein unfolding [PMID:32492414]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:11923285]" /note="Hsp40 chaperone with a role in SUMO-mediated protein degradation; works in concert with Hsp70 and Hsp110 (Sse1p) to promote disaggregation of intranuclear protein inclusions; competes with Hsp104 in disaggregation, supporting turnover instead of refolding; member of DnaJ-like family, conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; forms nuclear foci upon DNA replication stress" /codon_start=1 /product="Apj1p" /protein_id="DAA10468.1" /db_xref="SGD:S000005021" /translation="MQQNTSLYDSLNVTAAASTSEIKKAYRNAALKYHPDKNNHTEES KRKFQEICQAYEILKDNRLRALYDQYGTTDEVLIQEQQAQAQRQQAGPFSSSSNFDTE AMSFPDLSPGDLFAQFFNSSATPSSNGSKSSFNFSFNNSSTPSFSFVNGSGVNNLYSS SAKYNSNDEDHHLDRGPDIKHNLKCTLKELYMGKTAKLGLNRTRICSVCDGHGGLKKC TCKTCKGQGIQTQTRRMGPLVQSWSQTCADCGGAGVFVKNKDICQQCQGLGFIKERKI LQVTVQPGSCHNQLIVLTGEGDEVISTKGGGHEKVIPGDVVITILRLKDPNFQVINYS NLICKKCKIDFMTSLCGGVVYIEGHPSGKLIKLDIIPGEILKPGCFKTVEDMGMPKFI NGVRSGFGHLYVKFDVTYPERLEPENAKKIQNILANDKYIKAERSTMETADSDCYCDL EKSYDSVEEHVLSSFEAPNLNNEVIEDDDLGDLINERDSRKRNNRRFDESNINNNNET KRNKYSSPVSGFYDHDINGY" gene 483556..485310 /gene="MKS1" /locus_tag="YNL076W" /gene_synonym="LYS80" mRNA 483556..485310 /gene="MKS1" /locus_tag="YNL076W" /gene_synonym="LYS80" /product="Mks1p" CDS 483556..485310 /gene="MKS1" /locus_tag="YNL076W" /gene_synonym="LYS80" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10511541]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11882290]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11882290]" /experiment="EXISTENCE:mutant phenotype:GO:0006808 regulation of nitrogen utilization [PMID:10511541]" /experiment="EXISTENCE:mutant phenotype:GO:2000220 regulation of pseudohyphal growth [PMID:22043304]" /experiment="EXISTENCE:physical interaction:GO:0031930 mitochondria-nucleus signaling pathway [PMID:14536080]" /note="Pleiotropic negative transcriptional regulator; involved in Ras-cAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling" /codon_start=1 /product="Mks1p" /protein_id="DAA10469.1" /db_xref="SGD:S000005020" /translation="MSREAFDVPNIGTNKFLKVTPNLFTPERLNLFDDVELYLTLIKA SKCVEQGERLHNISWRILNKAVLKEHNINRSKKRDGVKNIYYVLNPNNKQPIKPKQAA VKQPPLQKANLPPTTAKQNVLTRPMTSPAIAQGAHDRSLDNPNSTNNDVKNDVAPNRQ FSKSTTSGLFSNFADKYQKMKNVNHVANKEEPQTIITGFDTSTVITKKPLQSRRSRSP FQHIGDMNMNCIDNETSKSTSPTLENMGSRKSSFPQKESLFGRPRSYKNDQNGQLSLS KTSSRKGKNKIFFSSEDEDSDWDSVSNDSEFYADEDDEEYDDYNEEEADQYYRRQWDK LLFAKNQQNLDSTKSSVSSANTINSNTSHDPVRKSLLSGLFLSEANSNSNNHNTAHSE YASKHVSPTPQSSHSNIGPQPQQNPPSANGIKQQKPSLKTSNVTALASLSPPQPSNNE RLSMDIQKDFKTDNESNHLYESNAPLTAQTILPTALSTHMFLPNNIHQQRMAIATGSN TRHRFSRRQSMDIPSKNRNTGFLKTRMEISEEEKMVRTISRLDNTSIANSNGNGNDDT SNQRTEALGRKTSNGGRI" gene 485607..486479 /gene="IMP4" /locus_tag="YNL075W" mRNA 485607..486479 /gene="IMP4" /locus_tag="YNL075W" /product="snoRNA-binding rRNA-processing protein IMP4" CDS 485607..486479 /gene="IMP4" /locus_tag="YNL075W" /experiment="EXISTENCE:direct assay:GO:0006364 rRNA processing [PMID:23980203]" /experiment="EXISTENCE:direct assay:GO:0030515 snoRNA binding [PMID:15489263]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309|PMID:12242301]" /experiment="EXISTENCE:direct assay:GO:0034457 Mpp10 complex [PMID:17515605]" /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:11864606]" /experiment="EXISTENCE:direct assay:GO:0042274 ribosomal small subunit biogenesis [PMID:23980203]" /experiment="EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:17803460]" /experiment="EXISTENCE:direct assay:GO:0140691 RNA folding chaperone [PMID:15489263]" /note="Subunit of the MPP10 chaperone complex and the small subunit (SSU) processome; contains both U3 snoRNA and rRNA primary transcript binding activity, as well as RNA chaperone activity; SSU processome is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs" /codon_start=1 /product="snoRNA-binding rRNA-processing protein IMP4" /protein_id="DAA10470.1" /db_xref="SGD:S000005019" /translation="MLRRQARERREYLYRKAQELQDSQLQQKRQIIKQALAQGKPLPK ELAEDESLQKDFRYDQSLKESEEADDLQVDDEYAATSGIMDPRIIVTTSRDPSTRLSQ FAKEIKLLFPNAVRLNRGNYVMPNLVDACKKSGTTDLVVLHEHRGVPTSLTISHFPHG PTAQFSLHNVVMRHDIINAGNQSEVNPHLIFDNFTTALGKRVVCILKHLFNAGPKKDS ERVITFANRGDFISVRQHVYVRTREGVEIAEVGPRFEMRLFELRLGTLENKDADVEWQ LRRFIRTANKKDYL" gene complement(486766..488124) /gene="MLF3" /locus_tag="YNL074C" /gene_synonym="YMK1" mRNA complement(486766..488124) /gene="MLF3" /locus_tag="YNL074C" /gene_synonym="YMK1" /product="Mlf3p" CDS complement(486766..488124) /gene="MLF3" /locus_tag="YNL074C" /gene_synonym="YMK1" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:16816427]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:16816427]" /experiment="EXISTENCE:genetic interaction:GO:0034605 cellular response to heat [PMID:16816427]" /note="Serine-rich hypothetical protein; predicted to be palmitoylated; overproduction suppresses growth inhibition caused by exposure to immunosuppressant leflunomide; MLF3 has a paralog, VHS2, that arose from the whole genome duplication" /codon_start=1 /product="Mlf3p" /protein_id="DAA10471.1" /db_xref="SGD:S000005018" /translation="MCVYKSNSNNSNPSFIFERTVQEASSNDLFLQPPVSASNTSHSS RSNSFYNLQTISPIPISGSEVRTPSLRKNSNNVSSPLDNVIPTSRSASNSTTSSLAHQ EYILNPICNMQNHHHRRRTLENSVAPALDASCSIVNDENTDLSDVDMVYSRRPSSAVS LNMALLARTNSATLPSSESSPASPDLKLSRSHSHSAATRPTLNNINNTGMTTTTSNGE PNSRILRFYSYVDMLNDEKLAQANNTPTSRPPMKSQAYSCPFILKRSPPQAYSSSSAT TTFSNPFIKTTELPATSPYVSPQQSARQYSNNANNNAKSPKNRSSSILFQRQSILSNV DPVANMHKNPKFQIESSDSEEEDLTMDMLDPSFPLSSSLRSSANLASNPELATQTPLS TSSSYTAIGKPMPLSTDPSYVSSSNTLSSEHELRVEKVSEVLKKKVSNGGFSTEFNSC DT" gene 488386..490116 /gene="MSK1" /locus_tag="YNL073W" mRNA 488386..490116 /gene="MSK1" /locus_tag="YNL073W" /product="lysine--tRNA ligase MSK1" CDS 488386..490116 /gene="MSK1" /locus_tag="YNL073W" /EC_number="6.1.1.6" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961|PMID:2016746]" /experiment="EXISTENCE:direct assay:GO:0008033 tRNA processing [PMID:17560369]" /experiment="EXISTENCE:mutant phenotype:GO:0004824 lysine-tRNA ligase activity [PMID:2016746]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:17560369]" /experiment="EXISTENCE:mutant phenotype:GO:0070154 mitochondrial lysyl-tRNA aminoacylation [PMID:2016746]" /note="Mitochondrial lysine-tRNA synthetase; required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)" /codon_start=1 /product="lysine--tRNA ligase MSK1" /protein_id="DAA10472.1" /db_xref="SGD:S000005017" /translation="MNVLLKRRSLTFAPRWLWCKCRSSRSRPYSLAHAVDTSKMEATR RNGQIVKDLGRYYPSMSESALHDLCQEYKEVTIADFNERFLGNPATLHHEDNPNLLLS INGRIKSIRFSGQKIVFIDLYNGSSGLKNDTQLQLIVNYNKIGGSSEDKANFSEYMNF LKKGDYIKALGYPGFSQSRVKMLSLICNKLPIVLSVSQLPLPSRLNDETKIKSNRVVD YQLNGTQTLLVRARIIKLLRKFLDDRNFVEVETPILSSKSNGAMAKPFITSSKDFDHL ELRIAPELWLKRLIISGLQKVYEIGKVFRNEGIDSTHNAEFSTLEFYETYMSMDDIVT RTEDLFKFLITNLQKFFQDTRLPVPKTFSELHLALSENNWKFRKVEFLPTLNKELGID LMNSGLDINKPSELLKALPKDIAKKYFPSADNTGQLSSLQILNKLSDVFLEQRHCQST LPTVIYHQPAILSPLAKTDPQNKQVTKRFEVFIKGKEYINAYEEENCPQLQLQKFLQQ KQINELTGNKTETLSPVIDYQYVETMKYGMPPVGGFGLGIDRLCMLFCDKKRIEEVLP FGCVDDVNRQ" gene 490317..491240 /gene="RNH201" /locus_tag="YNL072W" /gene_synonym="RNH35" mRNA 490317..491240 /gene="RNH201" /locus_tag="YNL072W" /gene_synonym="RNH35" /product="ribonuclease H2 catalytic subunit RNH201" CDS 490317..491240 /gene="RNH201" /locus_tag="YNL072W" /gene_synonym="RNH35" /EC_number="3.1.26.4" /experiment="EXISTENCE:direct assay:GO:0004523 RNA-DNA hybrid ribonuclease activity [PMID:14734815]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11029655]" /experiment="EXISTENCE:direct assay:GO:0032299 ribonuclease H2 complex [PMID:14734815]" /experiment="EXISTENCE:direct assay:GO:0043137 DNA replication, removal of RNA primer [PMID:10567561]" /experiment="EXISTENCE:genetic interaction:GO:0043137 DNA replication, removal of RNA primer [PMID:10567561]" /experiment="EXISTENCE:mutant phenotype:GO:0004523 RNA-DNA hybrid ribonuclease activity [PMID:14734815]" /note="Ribonuclease H2 catalytic subunit; removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; role in ribonucleotide excision repair; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome" /codon_start=1 /product="ribonuclease H2 catalytic subunit RNH201" /protein_id="DAA10473.1" /db_xref="SGD:S000005016" /translation="MVPPTVEASLESPYTKSYFSPVPSALLEQNDSPIIMGIDEAGRG PVLGPMVYAVAYSTQKYQDETIIPNYEFDDSKKLTDPIRRMLFSKIYQDNEELTQIGY ATTCITPLDISRGMSKFPPTRNYNLNEQAHDVTMALIDGVIKQNVKLSHVYVDTVGPP ASYQKKLEQRFPGVKFTVAKKADSLYCMVSVASVVAKVTRDILVESLKRDPDEILGSG YPSDPKTVAWLKRNQTSLMGWPANMVRFSWQTCQTLLDDASKNSIPIKWEEQYMDSRK NAAQKTKQLQLQMVAKPVRRKRLRTLDNWYR" gene 491523..492971 /gene="LAT1" /locus_tag="YNL071W" /gene_synonym="ODP2" /gene_synonym="PDA2" mRNA 491523..492971 /gene="LAT1" /locus_tag="YNL071W" /gene_synonym="ODP2" /gene_synonym="PDA2" /product="dihydrolipoyllysine-residue acetyltransferase" CDS 491523..492971 /gene="LAT1" /locus_tag="YNL071W" /gene_synonym="ODP2" /gene_synonym="PDA2" /EC_number="2.3.1.12" /experiment="EXISTENCE:direct assay:GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity [PMID:2271545]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11914276|PMID:14562095|PMID:14576278|PMID:16823961|P MID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006086 pyruvate decarboxylation to acetyl-CoA [PMID:7947791]" /experiment="EXISTENCE:direct assay:GO:0045254 pyruvate dehydrogenase complex [PMID:2007123|PMID:9038189]" /note="Dihydrolipoamide acetyltransferase component (E2) of the PDC; the pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA; metabolic longevity factor required for calorie restriction-mediated life span extension" /codon_start=1 /product="dihydrolipoyllysine-residue acetyltransferase" /protein_id="DAA10474.1" /db_xref="SGD:S000005015" /translation="MSAFVRVVPRISRSSVLTRSLRLQLRCYASYPEHTIIGMPALSP TMTQGNLAAWTKKEGDQLSPGEVIAEIETDKAQMDFEFQEDGYLAKILVPEGTKDIPV NKPIAVYVEDKADVPAFKDFKLEDSGSDSKTSTKAQPAEPQAEKKQEAPAEETKTSAP EAKKSDVAAPQGRIFASPLAKTIALEKGISLKDVHGTGPRGRITKADIESYLEKSSKQ SSQTSGAAAATPAAATSSTTAGSAPSPSSTASYEDVPISTMRSIIGERLLQSTQGIPS YIVSSKISISKLLKLRQSLNATANDKYKLSINDLLVKAITVAAKRVPDANAYWLPNEN VIRKFKNVDVSVAVATPTGLLTPIVKNCEAKGLSQISNEIKELVKRARINKLAPEEFQ GGTICISNMGMNNAVNMFTSIINPPQSTILAIATVERVAVEDAAAENGFSFDNQVTIT GTFDHRTIDGAKGAEFMKELKTVIENPLEMLL" gene 493366..493548 /gene="TOM7" /locus_tag="YNL070W" /gene_synonym="MOM7" /gene_synonym="YOK22" mRNA 493366..493548 /gene="TOM7" /locus_tag="YNL070W" /gene_synonym="MOM7" /gene_synonym="YOK22" /product="Tom7p" CDS 493366..493548 /gene="TOM7" /locus_tag="YNL070W" /gene_synonym="MOM7" /gene_synonym="YOK22" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005742 mitochondrial outer membrane translocase complex [PMID:9774667]" /experiment="EXISTENCE:mutant phenotype:GO:0005742 mitochondrial outer membrane translocase complex [PMID:8641278]" /experiment="EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:8641278]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:8641278]" /experiment="EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:8641278]" /note="Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex" /codon_start=1 /product="Tom7p" /protein_id="DAA10475.1" /db_xref="SGD:S000005014" /translation="MSFLPSFILSDESKERISKILTLTHNVAHYGWIPFVLYLGWAHT SNRPNFLNLLSPLPSV" gene complement(493956..495001) /gene="RPL16B" /locus_tag="YNL069C" /gene_synonym="RP23" mRNA complement(join(493956..494524,494974..495001)) /gene="RPL16B" /locus_tag="YNL069C" /gene_synonym="RP23" /product="60S ribosomal protein uL13 RPL16B" CDS complement(join(493956..494524,494974..495001)) /gene="RPL16B" /locus_tag="YNL069C" /gene_synonym="RP23" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:27374275]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:27374275]" /note="Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication" /codon_start=1 /product="60S ribosomal protein uL13 RPL16B" /protein_id="DAA10476.1" /db_xref="SGD:S000005013" /translation="MSQPVVVIDAKDHLLGRLASTIAKQVLNGQKIVVVRAEALNISG EFFRNKLKYHDFLRKATAFNKTRGPFHFRAPSRILYKAIRGMVSHKTARGKAALERLK IFEGIPPPYDKKKRVVVPQALRVLRLKPGRKYTTLGKLSTSVGWKYEDVVAKLEDKRK VRSAEYYAKKRAFTKKVSSASAAASESDVAKQLASFGY" gene complement(495701..498289) /gene="FKH2" /locus_tag="YNL068C" mRNA complement(495701..498289) /gene="FKH2" /locus_tag="YNL068C" /product="forkhead family transcription factor FKH2" CDS complement(495701..498289) /gene="FKH2" /locus_tag="YNL068C" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:24504085]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:22265405|PMID:24504085]" /experiment="EXISTENCE:direct assay:GO:0003712 transcription coregulator activity [PMID:10959837|PMID:15509804]" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:10899128]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:20847055|PMID:22932476|PMID:10899128]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:24504085]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:10959837|PMID:15509804|PMID:10899128|PMID:12711672]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:17898805]" /experiment="EXISTENCE:genetic interaction:GO:0000086 G2/M transition of mitotic cell cycle [PMID:11562353|PMID:15509804|PMID:10959837|PMID:10894548|P MID:10894549|PMID:10747051]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17898805|PMID:10894549]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:17283050]" /experiment="EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:12702877]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11562353|PMID:10959837|PMID:15509804|PMID:10747051|P MID:10894548]" /experiment="EXISTENCE:genetic interaction:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:10747051]" /experiment="EXISTENCE:genetic interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:15509804|PMID:10959837]" /experiment="EXISTENCE:genetic interaction:GO:2000221 negative regulation of pseudohyphal growth [PMID:10747051|PMID:10894548]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:10899128|PMID:10959837]" /experiment="EXISTENCE:mutant phenotype:GO:0003712 transcription coregulator activity [PMID:15509804]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:17283050]" /experiment="EXISTENCE:mutant phenotype:GO:0032298 positive regulation of DNA-templated DNA replication initiation [PMID:22265405]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:12702877]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10899128|PMID:10959837]" /experiment="EXISTENCE:mutant phenotype:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:10747051]" /experiment="EXISTENCE:mutant phenotype:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12711672|PMID:15509804|PMID:10899128]" /experiment="EXISTENCE:mutant phenotype:GO:1903468 positive regulation of DNA replication initiation [PMID:26728715]" /experiment="EXISTENCE:mutant phenotype:GO:2000221 negative regulation of pseudohyphal growth [PMID:10894548]" /note="Forkhead family transcription factor; rate-limiting activator of replication origins; evolutionarily conserved regulator of lifespan; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; positively regulates transcriptional elongation; facilitates clustering, activation of early-firing replication origins; negative role in chromatin silencing at HML and HMR; major role in expression of G2/M phase genes; relocalizes to cytosol under hypoxia" /codon_start=1 /product="forkhead family transcription factor FKH2" /protein_id="DAA10477.1" /db_xref="SGD:S000005012" /translation="MSSSNFNEMNELNMTQTNYGSTKYTAQHHQGVINAIISSLTAPD QPTTVSLQYSNDKNMATEIQAYAKLSGPNWTYYVKDLEVSIGRNTDPLNSALQENSDG VKNSYRVNIDLGPAKVVSRKHAIIKYNMNIGGWELHILGRNGAKVNFQRTHNGPNNPP IRLSSGTLLDIGGTQMMFILPDSDPVVAPICIEHLMPNLINMFGLEGNNNPLLRDIIK QSNYAKQRQLTSNQQIKGFKLYGSGGNAPFGSGANLGPSEQGIFNNNNNSKNKNGYFT SINPNYTASTTTSNTINPQAASPQGPPNTIIAANFVDSYKSSNAYPQALDFTSDLSHD ENRNVKPPHSYATMITQAILSSPEGVISLADIYKYISSNYAYYRFAKSGWQNSIRHNL SLNKAFEKVPRRPNEPGKGMKWRISESYQQEFLNKWNTGKVGKIRRGSSVARQLQLHM AKFNSLPMEMDYRLSLNMAQPPKRQLQSHNVLEPSNNNIIEGFVQHVPSKGNLPASQQ SQPPVSHQNQSQQPPPQEQRQEIQFTFADTQNRNIALARPIKTPQLQAPNSNANLNQN NMKEYKESLHPPAISISQMNRQSPNNALVSFTNACANSKIINNISDSADKSTNNNGGT KMNLPAISTSSLDENGNLEPTTTTSSGNSNSVPQTGTTTSSLAANSLRLSQPYDTLLR SPTKAFHITAMEAYTPERGSANRARSPLHSNSNNTNNNGANNSNLQTSGMENKQTGLV LDSNVLKSMESNNDNRRLTPSTSKSQNVKSSPGVWNLLQFSSTNNTPAADSGGNKRGF SINPDIKAKENENATSEKDSDSNSNDLETKDINSSPLKNQGGSTANAKELILDTDGAK ISIINN" rep_origin 498970..499154 /note="ARS1420; Autonomously Replicating Sequence" /db_xref="SGD:S000118388" gene 499417..499557 /locus_tag="YNL067W-B" /gene_synonym="YNL067W-A" mRNA 499417..499557 /locus_tag="YNL067W-B" /gene_synonym="YNL067W-A" /product="hypothetical protein" CDS 499417..499557 /locus_tag="YNL067W-B" /gene_synonym="YNL067W-A" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10478.1" /db_xref="SGD:S000028810" /translation="MCKLMWCTGVVSKTALLTGNFFFSSSEFFFKATHRKSENYLNGR QT" gene 499681..500256 /gene="RPL9B" /locus_tag="YNL067W" mRNA 499681..500256 /gene="RPL9B" /locus_tag="YNL067W" /product="60S ribosomal protein uL6 RPL9B" CDS 499681..500256 /gene="RPL9B" /locus_tag="YNL067W" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /note="Ribosomal 60S subunit protein L9B; homologous to mammalian ribosomal protein L9 and bacterial L6; RPL9B has a paralog, RPL9A, that arose from a single-locus duplication" /codon_start=1 /product="60S ribosomal protein uL6 RPL9B" /protein_id="DAA10479.1" /db_xref="SGD:S000005011" /translation="MKYIQTEQQIEIPEGVTVSIKSRIVKVVGPRGTLTKNLKHIDVT FTKVNNQLIKVAVHNGDRKHVAALRTVKSLVDNMITGVTKGYKYKMRYVYAHFPINVN IVEKDGAKFIEVRNFLGDKKIRNVPVRDGVTIEFSTNVKDEIVLSGNSVEDVSQNAAD LQQICRVRNKDIRKFLDGIYVSHKGFIVEDM" gene 501515..502777 /gene="SUN4" /locus_tag="YNL066W" /gene_synonym="SCW3" mRNA 501515..502777 /gene="SUN4" /locus_tag="YNL066W" /gene_synonym="SCW3" /product="putative glucosidase SUN4" CDS 501515..502777 /gene="SUN4" /locus_tag="YNL066W" /gene_synonym="SCW3" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:27229769]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11958935]" /note="Cell wall protein related to glucanases localized in birth scars; possibly involved in cell wall septation; member of the SUN family; SUN4 has a paralog, SIM1, that arose from the whole genome duplication" /codon_start=1 /product="putative glucosidase SUN4" /protein_id="DAA10480.1" /db_xref="SGD:S000005010" /translation="MKLSATTLTAASLIGYSTIVSALPYAADIDTGCTTTAHGSHQHK RAVAVTYVYETVTVDKNGQTVTPTSTEASSTVASTTTLISESSVTKSSSKVASSSEST EQIATTSSSAQTTLTSSETSTSESSVPISTSGSASTSSAASSATGSIYGDLADFSGPY EKFEDGTIPCGQFPSGQGVIPISWLDEGGWSGVENTDTSTGGSCKEGSYCSYACQPGM SKTQWPSDQPSDGRSIGGLLCKDGYLYRSNTDTDYLCEWGVDAAYVVSELSNDVAICR TDYPGTENMVIPTYVQAGDSLPLTVVDQDTYYTWQGLKTSAQYYVNNAGISVEDACVW GSSSSGVGNWAPLNFGAGSSDGVAYLSLIPNPNNGNALNFNVKIVAADDSSTVNGECI YENGSFSGGSDGCTVSVTAGKAKFVLYN" gene 503724..505484 /gene="AQR1" /locus_tag="YNL065W" mRNA 503724..505484 /gene="AQR1" /locus_tag="YNL065W" /product="Aqr1p" CDS 503724..505484 /gene="AQR1" /locus_tag="YNL065W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:34887841|PMID:11922628|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0032973 amino acid export across plasma membrane [PMID:15590823]" /experiment="EXISTENCE:mutant phenotype:GO:0008028 monocarboxylic acid transmembrane transporter activity [PMID:11922628]" /experiment="EXISTENCE:mutant phenotype:GO:0015565 threonine efflux transmembrane transporter activity [PMID:34887841]" /experiment="EXISTENCE:mutant phenotype:GO:0015718 monocarboxylic acid transport [PMID:11922628]" /experiment="EXISTENCE:mutant phenotype:GO:0032973 amino acid export across plasma membrane [PMID:34887841|PMID:15590823]" /experiment="EXISTENCE:mutant phenotype:GO:0042910 xenobiotic transmembrane transporter activity [PMID:11922628]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:11922628]" /note="Plasma membrane transporter of the major facilitator superfamily; involved in the excretion of excess amino acids; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; relocalizes from plasma membrane to cytoplasm upon DNA replication stress; AQR1 has a paralog, QDR1, that arose from the whole genome duplication" /codon_start=1 /product="Aqr1p" /protein_id="DAA10481.1" /db_xref="SGD:S000005009" /translation="MSRSNSIYTEDIEMYPTHNEQHLTREYTKPDGQTKSEKLNFEGA YINSHGTLSKTTTREIEGDLDSETSSHSSDDKVDPTQQITAETKAPYTLLSYGQKWGM VAILTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLA DCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFT LKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLIL PETKRTIAGNLSIKPKRFINRAPIFLLGPVRRRFKYDNPDYETLDPTIPKLDLSSAGK ILVLPEIILSLFPSGLLFAMWTLMLSSISSGLSVAPYNYHLVIIGVCYLPGGIGGLMG SFFTGRIIDMYFKRKIKKFEQDKANGLIPQDAEINMFKVRLVCLLPQNFLAVVAYLLF GWSIDKGWRIESILITSFVCSYCAMSTLSTSTTLLVDLYPTKSSTASSCFNFVRCSLS TIFMGCFAKMKAAMTVGGTFTFLCALVFFFNFLMFIPMKYGMKWREDRLLKQQRQSWL NTLAVKAKKGTKRDQNDNHN" gene complement(505868..507097) /gene="YDJ1" /locus_tag="YNL064C" /gene_synonym="HSP40" /gene_synonym="MAB3" /gene_synonym="MAS5" mRNA complement(505868..507097) /gene="YDJ1" /locus_tag="YNL064C" /gene_synonym="HSP40" /gene_synonym="MAB3" /gene_synonym="MAS5" /product="type I HSP40 co-chaperone YDJ1" CDS complement(505868..507097) /gene="YDJ1" /locus_tag="YNL064C" /gene_synonym="HSP40" /gene_synonym="MAB3" /gene_synonym="MAS5" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:15342786|PMID:1400408]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:1869583|PMID:26928762|PMID:8144572]" /experiment="EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:9674429]" /experiment="EXISTENCE:direct assay:GO:0048471 perinuclear region of cytoplasm [PMID:1869583]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:9774392]" /experiment="EXISTENCE:direct assay:GO:0072380 TRC complex [PMID:20850366]" /experiment="EXISTENCE:mutant phenotype:GO:0006458 'de novo' protein folding [PMID:10567418]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:25344756]" /experiment="EXISTENCE:mutant phenotype:GO:0006626 protein targeting to mitochondrion [PMID:1729605]" /experiment="EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:25853343]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:25344756]" /experiment="EXISTENCE:mutant phenotype:GO:0035719 tRNA import into nucleus [PMID:25853343]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:15252059|PMID:15342786]" /experiment="EXISTENCE:mutant phenotype:GO:0045047 protein targeting to ER [PMID:1473150]" /note="Type I HSP40 co-chaperone; regulates HSP90 and HSP70 functions; acts as an adaptor that helps Rsp5p recognize and ubiquitinate misfolded, cytosolic proteins after heat shock; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; forms cytotoxic amyloidogenic-like structures in vitro; DnaJ family member; chimeric protein in which the human p58IPK J domain replaces the yeast Ydj1p J domain can complement yeast ydj1 mutant" /codon_start=1 /product="type I HSP40 co-chaperone YDJ1" /protein_id="DAA10482.1" /db_xref="SGD:S000005008" /translation="MVKETKFYDILGVPVTATDVEIKKAYRKCALKYHPDKNPSEEAA EKFKEASAAYEILSDPEKRDIYDQFGEDGLSGAGGAGGFPGGGFGFGDDIFSQFFGAG GAQRPRGPQRGKDIKHEISASLEELYKGRTAKLALNKQILCKECEGRGGKKGAVKKCT SCNGQGIKFVTRQMGPMIQRFQTECDVCHGTGDIIDPKDRCKSCNGKKVENERKILEV HVEPGMKDGQRIVFKGEADQAPDVIPGDVVFIVSERPHKSFKRDGDDLVYEAEIDLLT AIAGGEFALEHVSGDWLKVGIVPGEVIAPGMRKVIEGKGMPIPKYGGYGNLIIKFTIK FPENHFTSEENLKKLEEILPPRIVPAIPKKATVDECVLADFDPAKYNRTRASRGGANY DSDEEEQGGEGVQCASQ" gene 507758..508702 /gene="MTQ1" /locus_tag="YNL063W" mRNA 507758..508702 /gene="MTQ1" /locus_tag="YNL063W" /product="S-adenosylmethionine-dependent methyltransferase" CDS 507758..508702 /gene="MTQ1" /locus_tag="YNL063W" /EC_number="2.1.1.297" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:16321977]" /experiment="EXISTENCE:genetic interaction:GO:0006451 translational readthrough [PMID:16321977]" /experiment="EXISTENCE:mutant phenotype:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:16321977]" /note="S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene" /codon_start=1 /product="S-adenosylmethionine-dependent methyltransferase" /protein_id="DAA10483.1" /db_xref="SGD:S000005007" /translation="MPRISTSLIRKASRIRPGLHLLLPECRTLEQAKLEYKWLTEELP PDKSIRWACLQRYKHVPLQYILRSQPFGALDIVCKPGVLIPRWETEEWVMAIIRALNN SMLSRHTIPLHICDTFTGTGCIALALSHGIANCTFTAIDVSTRAIKLVKENMLKNKVS GGKLVQHNILSSKASDEYPSHIDILTGNPPYIRKRDFNRDVKTSVKLFEPRLALVGEL ECYINLVNYWLPKTDSFFYEIGDVEQFNYVERRIKEDSYLSRIWSIGLKYDSNGKARV VYGFKATPKGRILHQIFASFGTIRHLATALSGHKANCN" gene complement(508776..510212) /gene="GCD10" /locus_tag="YNL062C" /gene_synonym="TRM6" mRNA complement(508776..510212) /gene="GCD10" /locus_tag="YNL062C" /gene_synonym="TRM6" /product="tRNA 1-methyladenosine methyltransferase subunit GCD10" CDS complement(508776..510212) /gene="GCD10" /locus_tag="YNL062C" /gene_synonym="TRM6" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9851972]" /experiment="EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:10779558]" /experiment="EXISTENCE:direct assay:GO:0031515 tRNA (m1A) methyltransferase complex [PMID:10779558]" /experiment="EXISTENCE:direct assay:GO:0160107 tRNA (adenine(58)-N1)-methyltransferase activity [PMID:10779558]" /experiment="EXISTENCE:physical interaction:GO:0031515 tRNA (m1A) methyltransferase complex [PMID:10779558]" /note="Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression" /codon_start=1 /product="tRNA 1-methyladenosine methyltransferase subunit GCD10" /protein_id="DAA10484.1" /db_xref="SGD:S000005006" /translation="MNALTTIDFNQHVIVRLPSKNYKIVELKPNTSVSLGKFGAFEVN DIIGYPFGLTFEIYYDGEEVSSDENRDSKPKNKIPIGKVRLLSQEIKDVNNDKDDGQS EPPLSIKEKSVSLELSSIDSSATNQNLVNMGSKAQELTVEEIEKMKQESLSSKEIIDK IIKSHKSFHNKTVYSQEKYVNRKKQKFAKYFTVEYLSSSNLLQFLIDKGDIQRVLDMS QESMGMLLNLANIQSEGNYLCMDETGGLLVYFLLERMFGGDNESKSKGKVIVIHENEH ANLDLLKFANYSEKFIKEHVHTISLLDFFEPPTLQEIQSRFTPLPKEEARALKGGKKN SYYRKLRWYNTQWQILELTGEFLYDGLVMATTLHLPTLVPKLAEKIHGSRPIVCYGQF KETLLELAHTLYSDLRFLAPSILETRCRPYQSIRGKLHPLMTMKGGGGYLMWCHRVIP APEPVSENATAADSSEKLAEHGAKKQKI" gene 510540..512396 /gene="NOP2" /locus_tag="YNL061W" /gene_synonym="YNA1" mRNA 510540..512396 /gene="NOP2" /locus_tag="YNL061W" /gene_synonym="YNA1" /product="rRNA (cytosine-C5-)-methyltransferase NOP2" CDS 510540..512396 /gene="NOP2" /locus_tag="YNL061W" /gene_synonym="YNA1" /EC_number="2.1.1.310" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:26196125|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:22735702|PMID:17443350]" /experiment="EXISTENCE:direct assay:GO:0070475 rRNA base methylation [PMID:23913415]" /experiment="EXISTENCE:genetic interaction:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]" /experiment="EXISTENCE:genetic interaction:GO:0070475 rRNA base methylation [PMID:23913415]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:8972218]" /experiment="EXISTENCE:mutant phenotype:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:8972218]" /experiment="EXISTENCE:mutant phenotype:GO:0070475 rRNA base methylation [PMID:23913415]" /experiment="EXISTENCE:mutant phenotype:GO:1902626 assembly of large subunit precursor of preribosome [PMID:22735702]" /note="rRNA m5C methyltransferase; methylates cytosine at position 2870 of 25S rRNA; has an essential function independent of rRNA methylation; contains seven beta-strand methyltransferase motif; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles; rRNA methylation defect and lethality are functionally complemented by human NOP2, a gene upregulated in cancer" /codon_start=1 /product="rRNA (cytosine-C5-)-methyltransferase NOP2" /protein_id="DAA10485.1" /db_xref="SGD:S000005005" /translation="MGSRRHKNKQAAPPTLEEFQARKEKKANRKLEKGKRPSTTQGDE VSDRKKKKSKPFKKSRKEEEEVVEEDKDLPEVDLEELSKARKSLFDDEEDDDEAGLVD EELKDEFDLEQEYDYDEDEDNDAHPIFSDDDDEADLEELNAQNMEALSKKLDEEEAEE AEEAEMELVEAENMQPRADILPTEEQEEMMAQETPNLTSTRTRMIEIVKVLENFKTLG AEGRSRGEYVDRLLKDICEYFGYTPFLAEKLFNLFSPAEAMEFFEANEIARPITIRTN TLKTRRRDLAQTLVNRGVNLQPIGSWTKVGLQIFDSQVPIGATPEYLAGHYILQAASS FLPVIALDPHENERILDMAAAPGGKTTYISAMMKNTGCVFANDANKSRTKSLIANIHR LGCTNTIVCNYDAREFPKVIGGFDRILLDAPCSGTGVIGKDQSVKVSRTEKDFIQIPH LQKQLLLSAIDSVDCNSKHGGVIVYSTCSVAVEEDEAVIDYALRKRPNVKLVDTGLAI GKEAFTSYRGKKFHPSVKLARRYYPHTYNVDGFFVAKFQKIGPSSFDDNQASAKEKET AARKEALEEGIIHSDFATFEDEEDDKYIEKSVKNNLLKKGVNPKAKRPSNEK" gene complement(512668..514935) /gene="ARP5" /locus_tag="YNL059C" mRNA complement(512668..514935) /gene="ARP5" /locus_tag="YNL059C" /product="actin-related protein ARP5" CDS complement(512668..514935) /gene="ARP5" /locus_tag="YNL059C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10923024|PMID:11011149]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12887900]" /experiment="EXISTENCE:direct assay:GO:0030234 enzyme regulator activity [PMID:26306040]" /experiment="EXISTENCE:direct assay:GO:0031011 Ino80 complex [PMID:12887900|PMID:15525518]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:12887900]" /experiment="EXISTENCE:mutant phenotype:GO:0031011 Ino80 complex [PMID:12887900]" /experiment="EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:15525518]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]" /note="Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction" /codon_start=1 /product="actin-related protein ARP5" /protein_id="DAA10486.1" /db_xref="SGD:S000005004" /translation="MSSRDASLTPLKAVVIDDPPLRQTPEPFDEQSAYNPQSPIAIDF GSSKLRAGFVNHATPTHIFPNALTKFRDRKLNKNFTFVGNDTLLDQAVRSQSRSPFDG PFVTNWNLTEEILDYTFHHLGVVPDNGIPNPILLTERLATVQSQRTNWYQILFETYNV PGVTFGIDSLFSFYNYNPSGNKTGLVISCGHEDTNVIPVVDGAGILTDAKRINWGGHQ AVDYLNDLMALKYPYFPTKMSYLQYETMYKDYCYVSRNYDEDIEKILTLENLDTNDVV VEAPFTEVLQPQKTEEELRIQAEKRKETGKRLQEQARLKRMEKLVQKQEEFEYFSKVR DQLIDEPKKKVLSVLQNAGFDDERDFKKYLHSLEQSLKKAQMVEAEDDSHLDEMNEDK TAQKFDLLDIADEDLNEDQIKEKRKQRFLKASQDARQKAKEEKERVAKEEEEKKLKEQ QWRETDLNGWIKDKRLKLNKLIKRRKEKLKLRDEMKDRKSQVSQNRMKNLASLAEDNV KQGAKRNRHQATIDNDPNDTFGANDEDWLIYTDITQNPEAFEEALEYEYKDIVELERL LLEHDPNFTEEDTLEAQYDWRNSILHLFLRGPRPHDSENIHEQHQMHLNVERIRVPEV IFQPTMGGQDQAGICELSETILLKKFGSQPGKLSQTSIDMVNNVLITGGNAKVPGLKE RIVKEFTGFLPTGTNITVNMSSDPSLDAWKGMAALARNEEQYRKTVISKKEYEEYGPE YIKEHKLGNTKYFED" gene complement(515763..516713) /locus_tag="YNL058C" mRNA complement(515763..516713) /locus_tag="YNL058C" /product="hypothetical protein" CDS complement(515763..516713) /locus_tag="YNL058C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to vacuole; not an essential gene; YNL058C has a paralog, PRM5, that arose from the whole genome duplication" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10487.1" /db_xref="SGD:S000005003" /translation="MVKKNFIPSVSLVRRDLPTLVTTTTSSTALSKPTSSVVSETSSK SLPSLTSSAFSTSSGATSSSSLIVASITPPSTAGNPFILNAADKPNGTVYIAVGAVIG AIFISILIWWLVSSYLSRRFTMTNSYANDSKNLYRGHHKHSSSLQSNPFDINDEKSYM QDDWDSMSQLESSQYEDAASPFNPIQDPFTDNRRSLFISPTLQVSQYEKSHSRHQSKD TNIFIDDPFLYVGTYLEEEEEEEEERKLNLNRPQRAASPERKEKKINSMEGYHKRNQS SLGLIPVASATSNTSSPKKAHKRQAPSMFLDDVLNGREII" gene 517249..517842 /gene="OCA2" /locus_tag="YNL056W" mRNA 517249..517842 /gene="OCA2" /locus_tag="YNL056W" /product="Oca2p" CDS 517249..517842 /gene="OCA2" /locus_tag="YNL056W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; similar to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene" /codon_start=1 /product="Oca2p" /protein_id="DAA10488.1" /db_xref="SGD:S000005001" /translation="MKYIPPLNFSPVVSTDVSLYRSGYPMPLNYSFIKHQLHLKTIIY IGDKDRPLEEYQSFLESEKIKYYHIFMDSSRDEGIQERMNQVLHLVLDVRNYPILVHS NKGKHRVGVVVGIIRKLLQGWSTAGICQEYGLFSGGMKDGVDLEFITMFETNLKIPRN VIPGFAKHCLYLNELEAAEGSDDESGSESILTAKQPI" gene complement(517994..518845) /gene="POR1" /locus_tag="YNL055C" /gene_synonym="OMP2" mRNA complement(517994..518845) /gene="POR1" /locus_tag="YNL055C" /gene_synonym="OMP2" /product="porin POR1" CDS complement(517994..518845) /gene="POR1" /locus_tag="YNL055C" /gene_synonym="OMP2" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:7499333|PMID:16689936|PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0006811 monoatomic ion transport [PMID:9593723]" /experiment="EXISTENCE:direct assay:GO:0008308 voltage-gated monoatomic anion channel activity [PMID:9593723]" /experiment="EXISTENCE:direct assay:GO:0017128 phospholipid scramblase activity [PMID:38065946]" /experiment="EXISTENCE:direct assay:GO:0048039 ubiquinone binding [PMID:38906315|PMID:28051849]" /experiment="EXISTENCE:mutant phenotype:GO:0005741 mitochondrial outer membrane [PMID:38065946]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:17822411]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:11488609]" /experiment="EXISTENCE:mutant phenotype:GO:0042307 positive regulation of protein import into nucleus [PMID:29359182]" /experiment="EXISTENCE:mutant phenotype:GO:0045332 phospholipid translocation [PMID:38065946]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:18768136]" /experiment="EXISTENCE:mutant phenotype:GO:0051027 DNA transport [PMID:19056337]" /experiment="EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]" /experiment="EXISTENCE:physical interaction:GO:0044289 mitochondrial inner-outer membrane contact site [PMID:37073556]" /note="Mitochondrial porin and phospholipid scramblase; voltage-dependent anion channel in the outer mitochondrial membrane required for maintenance of mitochondrial osmotic stability and membrane permeability; scramblase involved in mitochondrial transbilayer translocation of phospholipids; ubiquinone binding protein; couples glutathione pools of the intermembrane space and the cytosol; phosphorylated; protein abundance increases in response to DNA replication stress; orthologous to human VDAC1 and 2" /codon_start=1 /product="porin POR1" /protein_id="DAA10489.1" /db_xref="SGD:S000005000" /translation="MSPPVYSDISRNINDLLNKDFYHATPAAFDVQTTTANGIKFSLK AKQPVKDGPLSTNVEAKLNDKQTGLGLTQGWSNTNNLQTKLEFANLTPGLKNELITSL TPGVAKSAVLNTTFTQPFFTARGAFDLCLKSPTFVGDLTMAHEGIVGGAEFGYDISAG SISRYAMALSYFAKDYSLGATLNNEQITTVDFFQNVNAFLQVGAKATMNCKLPNSNVN IEFATRYLPDASSQVKAKVSDSGIVTLAYKQLLRPGVTLGVGSSFDALKLSEPVHKLG WSLSFDA" gene complement(519099..519169) /locus_tag="YNCN0008C" tRNA complement(519099..519169) /locus_tag="YNCN0008C" /product="tRNA-Asp" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Aspartate tRNA (tRNA-Asp), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006544" mobile_element 519163..525062 /note="YNLWTy1-2; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats" /mobile_element_type="retrotransposon:YNLWTy1-2" /db_xref="SGD:S000007142" repeat_region 519163..519496 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007136" gene 519456..524706 /locus_tag="YNL054W-B" mRNA 519456..524706 /locus_tag="YNL054W-B" /product="gag-pol fusion protein" CDS join(519456..520760,520762..524706) /locus_tag="YNL054W-B" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage /note="TyB Gag-Pol protein; proteolytically processed to make the Gag, reverse transcriptase (RT), protease (PR), and integrase (IN) proteins that are required for retrotransposition" /codon_start=1 /product="gag-pol fusion protein" /protein_id="DAA64521.1" /db_xref="SGD:S000007385" /translation="MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKIQEYD KASTKANSQQTTTPASSAVPENPHHASPQTAQSHSPQNGPYPQQCMMTQNQANPSDWS FYGRPSMIPYTPYQMSPMYFPPGPHSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS DMTSTKKYVRPPPMLTSPNDFLNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM TVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNN SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHS DDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQD NTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWV SKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNE SDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKS APSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSE YTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFS AIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGI PGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLT ASYQSFIASNEIQQSDDLNFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVS KTNIRAPREVDPNISKSDILPSKKRSSTPQISDIESTGSGGMHRLDVPLLAPMSQSNT HESSHTSKSKDFRHSDSYSDNETNHTNVPISSTGGTNNKTVPQTSEQETEKRIIHRSP SIDTSSSESNSLHHVVPIKTSDTCPKENTEESIIADLPLPDLPPEPPTKLSDSFKELP PINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSK KRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWD TDKYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHY ALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGL KQSGANWYETIKSYLIEQCDMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKI ITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRSKYMKLGMEKSLTEKLPKLNVHL NPKGKKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYI NTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTKPDNKLVAISDASYGNQ PYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEIHAVSEAIPLLNNLSHLVQELN KKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKN IADVMTKPLPIKTFKLLTNKWIH" gene 519456..520778 /locus_tag="YNL054W-A" mRNA 519456..520778 /locus_tag="YNL054W-A" /product="gag protein" CDS 519456..520778 /locus_tag="YNL054W-A" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /codon_start=1 /product="gag protein" /protein_id="DAA10490.1" /db_xref="SGD:S000007384" /translation="MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKIQEYD KASTKANSQQTTTPASSAVPENPHHASPQTAQSHSPQNGPYPQQCMMTQNQANPSDWS FYGRPSMIPYTPYQMSPMYFPPGPHSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS DMTSTKKYVRPPPMLTSPNDFLNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM TVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNN SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPETY" repeat_region 524729..525062 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007137" gene 526086..529583 /gene="VAC7" /locus_tag="YNL054W" mRNA 526086..529583 /gene="VAC7" /locus_tag="YNL054W" /product="Vac7p" CDS 526086..529583 /gene="VAC7" /locus_tag="YNL054W" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:9372916|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:9372916]" /experiment="EXISTENCE:direct assay:GO:0070772 PAS complex [PMID:19037259]" /experiment="EXISTENCE:genetic interaction:GO:0008047 enzyme activator activity [PMID:11950935]" /experiment="EXISTENCE:genetic interaction:GO:0010513 positive regulation of phosphatidylinositol biosynthetic process [PMID:11950935]" /experiment="EXISTENCE:mutant phenotype:GO:1903778 protein localization to vacuolar membrane [PMID:17699591]" /experiment="EXISTENCE:physical interaction:GO:0070772 PAS complex [PMID:19037259]" /note="Integral vacuolar membrane protein; involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock; targeted to vacuole via AP-3 pathway" /codon_start=1 /product="Vac7p" /protein_id="DAA10491.1" /db_xref="SGD:S000004999" /translation="MTEEDRKLTVETETVEAPVANNLLLSNNSNVVAPNPSIPSASTS TSPLHREIVDDSVATANTTSNVVQHNLPTIDNNLMDSDATSHNQDHWHSDINRAGTSM STSDIPTDLHLEHIGSVSSTNNNSNNALINHNPLSSHLSNPSSSLRNKKSSLLVASNP AFASDVELSKKKPAVISNNMPTSNIALYQTARSANIHGPSSTSASKAFRKASAFSNNT APSTSNNIGSNTPPAPLLPLPSLSQQNKPKIIERPTMHVTNSREILLGENLLDDTKAK NAPANSTTHDNGPVANDGLRIPNHSNADDNENNNKMKKNKNINSGKNERNDDTSKICT TSTKTAPSTAPLGSTDNTQALTASVSSSNADNHNNNKKKTSSNNNGNNSNSASNKTNA DIKNSNADLSASTSNNNAINDDSHESNSEKPTKADFFAARLATAVGENEISDSEETFV YESAANSTKNLIFPDSSSQQQQQQQQPPKQQQQQQNHGITSKISAPLLNNNKKLLSRL KNSRHISTGAILNNTIATISTNPNLNSNVMQNNNNLMSGHNHLDELSSIKQEPPHQLQ QQQPPMDVQSVDSYTSDNPDSNVIAKSPDKRSSLVSLSKVSPHLLSSTSSNGNTISCP NVATNSQELEPNNDISTKKSLSNSTLRHSSANRNSNYGDNKRPLRTTVSKIFDSNPNG APLRRYSGVPDHVNLEDYIEQPHNYPTMQNSVKKDEFYNSRNNKFPHGLNFYGDNNVI EEENNGDSSNVNRPQHTNLQHEFIPEDNESDENDIHSMFYYNHKNDLETKPLISDYGE DEDVDDYDRPNATFNSYYGSASNTHELPLHGRMPSRSNNDYYDFMVGNNTGNNNQLNE YTPLRMKRGQRHLSRTNNSIMNGSIHMNGNDDVTHSNINNNDIVGYSPHNFYSRKSPF VKVKNFLYLAFVISSLLMTGFILGFLLATNKELQDVDVVVMDNVISSSDELIFDITVS AFNPGFFSISVSQVDLDIFAKSSYLKCDSNGDCTVMEQERKILQITTNLSLVEESANN DISGGNIETVLLGTAKKLETPLKFQGGAFNRNYDVSVSSVKLLSPGSREAKHENDDDD DDDGDDGDDENNTNERQYKSKPNARDDKEDDTKKWKLLIKHDYELIVRGSMKYEVPFF NTQKSTAIQKDSMVHPGKK" gene 529942..531411 /gene="MSG5" /locus_tag="YNL053W" mRNA 529942..531411 /gene="MSG5" /locus_tag="YNL053W" /product="tyrosine/serine/threonine protein phosphatase MSG5" CDS 529942..531411 /gene="MSG5" /locus_tag="YNL053W" /EC_number="3.1.3.48" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17963515|PMID:17952059]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17963515|PMID:17952059|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008138 protein tyrosine/serine/threonine phosphatase activity [PMID:8306972]" /experiment="EXISTENCE:direct assay:GO:0071852 fungal-type cell wall organization or biogenesis [PMID:14703512]" /experiment="EXISTENCE:direct assay:GO:1903138 negative regulation of cell integrity MAPK cascade [PMID:8306972|PMID:14703512]" /experiment="EXISTENCE:genetic interaction:GO:0071852 fungal-type cell wall organization or biogenesis [PMID:10625705|PMID:11923319]" /experiment="EXISTENCE:genetic interaction:GO:1903138 negative regulation of cell integrity MAPK cascade [PMID:10625705|PMID:11923319]" /experiment="EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:14703512]" /experiment="EXISTENCE:mutant phenotype:GO:0071507 pheromone response MAPK cascade [PMID:8306972]" /experiment="EXISTENCE:mutant phenotype:GO:0071852 fungal-type cell wall organization or biogenesis [PMID:10625705|PMID:14703512]" /experiment="EXISTENCE:mutant phenotype:GO:1903138 negative regulation of cell integrity MAPK cascade [PMID:14703512|PMID:10625705|PMID:8306972]" /note="Dual-specificity protein phosphatase; maintains low levels of both basal and induced cell integrity pathway signaling by dephosphorylation of the Slt2p MAPK; reciprocally regulated by Slt2p through phosphorylation; minor role with Ptp2p in the adaptive response to pheromone through the dephosphorylation of the Fus3p MAPK with major contribution by Ptp3p; inhibits the nuclear accumulation of Fus3p; two isoforms exist as the result of alternative translation initiation starts" /codon_start=1 /product="tyrosine/serine/threonine protein phosphatase MSG5" /protein_id="DAA10492.1" /db_xref="SGD:S000004998" /translation="MQFHSDKQHLDSKTDIDFKPNSPRSLQNRNTKNLSLDIAALHPL MEFSSPSQDVPGSVKFPSPTPLNLFMKPKPIVLEKCPPKVSPRPTPPSLSMRRSEASI YTLPTSLKNRTVSPSVYTKSSTVSSISKLSSSSPLSSFSEKPHLNRVHSLSVKTKDLK LKGIRGRSQTISGLETSTPISSTREGTLDSTDVNRFSNQKNMQTTLIFPEEDSDLNID MVHAEIYQRTVYLDGPLLVLPPNLYLYSEPKLEDILSFDLVINVAKEIPNLEFLIPPE MAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYI MRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTMLSKNSPGEEGETVHMPEEDD IGNNEVSSTTKSYSSASFRSFPMVTNLSSSPNDSSVNSSEVTPRTPATLTGARTALAT ERGEDDEHCKSLSQPADSLEASVDNESISTAPEQMMFLP" gene 531725..532186 /gene="COX5A" /locus_tag="YNL052W" mRNA 531725..532186 /gene="COX5A" /locus_tag="YNL052W" /product="cytochrome c oxidase subunit Va" CDS 531725..532186 /gene="COX5A" /locus_tag="YNL052W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:1331058]" /experiment="EXISTENCE:direct assay:GO:0045277 respiratory chain complex IV [PMID:1331058]" /experiment="EXISTENCE:mutant phenotype:GO:0004129 cytochrome-c oxidase activity [PMID:1847916]" /note="Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication" /codon_start=1 /product="cytochrome c oxidase subunit Va" /protein_id="DAA10493.1" /db_xref="SGD:S000004997" /translation="MLRNTFTRAGGLSRITSVRFAQTHALSNAAVMDLQSRWENMPST EQQDIVSKLSERQKLPWAQLTEPEKQAVWYISYGEWGPRRPVLNKGDSSFIAKGVAAG LLFSVGLFAVVRMAGGQDAKTMNKEWQLKSDEYLKSKNANPWGGYSQVQSK" gene 532659..533870 /gene="COG5" /locus_tag="YNL051W" /gene_synonym="API4" /gene_synonym="COD4" mRNA 532659..533870 /gene="COG5" /locus_tag="YNL051W" /gene_synonym="API4" /gene_synonym="COD4" /product="Golgi transport complex subunit COG5" CDS 532659..533870 /gene="COG5" /locus_tag="YNL051W" /gene_synonym="API4" /gene_synonym="COD4" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0017119 Golgi transport complex [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:20065092]" /note="Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" /codon_start=1 /product="Golgi transport complex subunit COG5" /protein_id="DAA10494.1" /db_xref="SGD:S000004996" /translation="MTIAPMANDLEDFESLLEPDFDAKQFGNDLLKATNNNDTTILDL NTPLKKLNYDLHEIDSRIDQLMNSNPLEIIELIYKNEHVNSTIVGELKPSLGYMNMSY DRLKNQVLDPYERARKVQLALSKVYQTSFLLRGALLYIHLSNKLNALSKTAQLSTSTA INLASLHYQLEITLEENKNLKSLRKIKQLDQDIVSPNKRELITFLSLQMCKECLNSIK IKSNKEIISQLAYSLYLLSSQEFESAINKIVLSNVTMSSQILSKILNSIRMFPDAFNE VVEKGYNIYILETLLQNIKTDNVTNSSRSIAANKSRLGNLLSEYTSMKSKAGSGTPRD LFWSKVSSAFKKDFDISVNRGGPVGKSLLKNKDFIINTMKQSMKKSSDNSDYQSYLDV MLNSVSISLNK" gene complement(534079..534982) /locus_tag="YNL050C" mRNA complement(join(534079..534874,534966..534982)) /locus_tag="YNL050C" /product="hypothetical protein" CDS complement(join(534079..534874,534966..534982)) /locus_tag="YNL050C" /note="hypothetical protein; YNL050c is not an essential gene" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10495.1" /db_xref="SGD:S000004995" /translation="MSEFKIVSRKDLYNEGEGLGEDYDSNSSSKNNSEHVEVLVPPTE FEFVEVERTDSSLDLKESNNSAHEQKEEKQEEFEFPLFSFGVVEASTSPAQEEQGSST QEKDTPQTEVSLMKISLKEPEEEIINQERPKDYYFASYSADQKLQFQQSSIDYDVIIQ ESTKILEDDLRIRDKWPYCQGRIIDLYKHNARIELEQQKELKIKKRRPGQKQRAAKKL ALERTKERDTKAREIKKQLKKKFHKRGGKKNKKKVPLNPLAKAGSTPKFRTE" gene complement(535281..537911) /gene="SFB2" /locus_tag="YNL049C" /gene_synonym="ISS1" mRNA complement(535281..537911) /gene="SFB2" /locus_tag="YNL049C" /gene_synonym="ISS1" /product="COPII subunit SFB2" CDS complement(535281..537911) /gene="SFB2" /locus_tag="YNL049C" /gene_synonym="ISS1" /experiment="EXISTENCE:direct assay:GO:0090110 COPII-coated vesicle cargo loading [PMID:10712514]" /experiment="EXISTENCE:genetic interaction:GO:0090110 COPII-coated vesicle cargo loading [PMID:10712514|PMID:12941277]" /experiment="EXISTENCE:physical interaction:GO:0030127 COPII vesicle coat [PMID:10749860|PMID:10753972]" /note="Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SFB2 has a paralog, SEC24, that arose from the whole genome duplication" /codon_start=1 /product="COPII subunit SFB2" /protein_id="DAA10496.1" /db_xref="SGD:S000004994" /translation="MSHHKKRVYPQAQVPYIASMPIVAEQQQSQQQIDQTAYAMGNLQ LNNRANSFTQLAQNQQFPGSGKVVNQLYPVDLFTELPPPIRDLSLPPLPITISQDNIV TPSEYSNVPYQYVRSTLKAVPKTNSLLKKTKLPFAIVIRPYLHLQDSDNQVPLNTDGV IVRCRRCRSYMNPFVVFINQGRKWQCNICRFKNDVPFGFDQNLQGAPINRYERNEIKN SVVDYLAPVEYSVREPPPSVYVFLLDVSQNAVKNGLLATSARTILENIEFLPNHDGRT RIAIICVDHSLHYFYVPLDDDYEVSDEDDEESDGEEEDEDEEEEDVDNSETIQMFDIG DLDEPFLPMPSDELVVPLKYCKNNLETLLKKIPEIFQDTHSSKFALGPALKAASNLIK STGGKVEVISSTLPNTGIGKLKKRSEQGILNTPKESSQLLSCKDSFYKTFTIECNKLQ ITVDMFLASEDYMDVATLSHLGRFSGGQTHFYPGFNATSLNDVTKFTRELSRHLSMDI SMEAVMRVRCSTGLRATSFFGHFFNRSSDLCAFSTMPRDQSYLFGISIEDSLMAEYCY LQVSTLLTLNTGERRIRVMTLALPTSESAREVFASADQLAITDFMTQNAVTKALNSSM YSARDFITKSLEDILNAYKKEISMSNINSVTSLNLCANLRMLPLLMNGLSKHIALRPG VVPSDYRASALNRLETEPLHYLIKSIYPTVYSLHDMPDEVGLPDFEGKTVLPEPINAT ISLFERYGLYLIDNSAELFLWVGGDAVPELLIDVFNTDTISQIPVGKSELPLLNDSPF NERLRRIIGRIRENNDTITFQSLYIIRGPSINEPANLNSEKDMASLRLWVLSTLVEDK VLNCASYREYLQSMKTSINR" gene 538173..539819 /gene="ALG11" /locus_tag="YNL048W" mRNA 538173..539819 /gene="ALG11" /locus_tag="YNL048W" /product="alpha-1,2-mannosyltransferase ALG11" CDS 538173..539819 /gene="ALG11" /locus_tag="YNL048W" /EC_number="2.4.1.131" /experiment="EXISTENCE:direct assay:GO:0004377 GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [PMID:16878994]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11278778]" /experiment="EXISTENCE:direct assay:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:16878994]" /experiment="EXISTENCE:mutant phenotype:GO:0000026 alpha-1,2-mannosyltransferase activity [PMID:11278778]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:11278778]" /note="Alpha-1,2-mannosyltransferase; catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER" /codon_start=1 /product="alpha-1,2-mannosyltransferase ALG11" /protein_id="DAA10497.1" /db_xref="SGD:S000004993" /translation="MGSAWTNYNFEEVKSHFGFKKYVVSSLVLVYGLIKVLTWIFRQW VYSSLNPFSKKSSLLNRAVASCGEKNVKVFGFFHPYCNAGGGGEKVLWKAVDITLRKD AKNVIVIYSGDFVNGENVTPENILNNVKAKFDYDLDSDRIFFISLKLRYLVDSSTWKH FTLIGQAIGSMILAFESIIQCPPDIWIDTMGYPFSYPIIARFLRRIPIVTYTHYPIMS KDMLNKLFKMPKKGIKVYGKILYWKVFMLIYQSIGSKIDIVITNSTWTNNHIKQIWQS NTCKIIYPPCSTEKLVDWKQKFGTAKGERLNQAIVLAQFRPEKRHKLIIESFATFLKN LPDSVSPIKLIMAGSTRSKQDENYVKSLQDWSENVLKIPKHLISFEKNLPFDKIEILL NKSTFGVNAMWNEHFGIAVVEYMASGLIPIVHASAGPLLDIVTPWDANGNIGKAPPQW ELQKKYFAKLEDDGETTGFFFKEPSDPDYNTTKDPLRYPNLSDLFLQITKLDYDCLRV MGARNQQYSLYKFSDLKFDKDWENFVLNPICKLLEEEERG" gene complement(539911..541881) /gene="SLM2" /locus_tag="YNL047C" /gene_synonym="LIT1" mRNA complement(539911..541881) /gene="SLM2" /locus_tag="YNL047C" /gene_synonym="LIT1" /product="phosphatidylinositol 4,5-bisphosphate-binding protein" CDS complement(539911..541881) /gene="SLM2" /locus_tag="YNL047C" /gene_synonym="LIT1" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15689497|PMID:15372071]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0001558 regulation of cell growth [PMID:15689497]" /experiment="EXISTENCE:genetic interaction:GO:0016197 endosomal transport [PMID:21451250]" /experiment="EXISTENCE:genetic interaction:GO:0030036 actin cytoskeleton organization [PMID:15372071]" /experiment="EXISTENCE:genetic interaction:GO:0051017 actin filament bundle assembly [PMID:15689497]" /experiment="EXISTENCE:genetic interaction:GO:0070941 eisosome assembly [PMID:21451250]" /experiment="EXISTENCE:genetic interaction:GO:0072659 protein localization to plasma membrane [PMID:22307609]" /experiment="EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:15689497]" /experiment="EXISTENCE:physical interaction:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:15689497]" /experiment="EXISTENCE:physical interaction:GO:0031929 TOR signaling [PMID:15689497]" /note="Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; TORC2 complex substrate and effector; SLM2 has a paralog, SLM1, that arose from the whole genome duplication" /codon_start=1 /product="phosphatidylinositol 4,5-bisphosphate-binding protein" /protein_id="DAA10498.1" /db_xref="SGD:S000004992" /translation="MSYQRNSARASLDLRSQYQQLEGRMRSEHFNPAYQQQQQKGQNI PLSLPSSLAQRNPIPYPIDAVTSDPTIPAQLNVYDHDRQNSIVDAAAGTNTTHSLNSN NIPSSQNNNINNNNINNVGSFTDPSMLTLPKMSLHSHQKQYDSNQNDPRSPLAILIPT SAQPTDVLSARFSAWRNVIRAILVYLSETASIQDEIVRQQLRLSHAVQFPFFSIENQY QPVSNEDKSMQKFFLPLGSGSVQDLPTMLTKYHDNLASLASKSSKELTSEIIPRLEDL RRDLLVKIKEIKALQSDFKNSCNKELQQTKHLMKLFNESLKECKLGTPKSDPFLIKLQ LEKQIKRQLVEENYLHEAFDNLQNSGAQLESVIVMEIQNGLTSYARILGKEAQVVFDS VISKLDSTILNKNTNLEWDSFILRNISNFVPPNLPMRRFKEISYSNQNDPFTFEVKSG FLEKRSKFLKSYSRGFYVLTPSFLHEFKTPDKHKFSTPLMSIPLVECTVTEHSKKTKS NSEQGKNKFILRTNSNGLIHRGHNWVFKVDSYDDMIEWFGNIKALSSLPNYDDKCKYV SKVAKLSKEKAKSNENTTESVTPQVTNEQHTRYDDVSSSNFPLNSIPKLDNLTITNTT SSIPETNDSQIQNRVPEFYIENVDSPRKSNQL" gene 542304..542822 /locus_tag="YNL046W" mRNA 542304..542822 /locus_tag="YNL046W" /product="hypothetical protein" CDS 542304..542822 /locus_tag="YNL046W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /note="hypothetical protein; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10499.1" /db_xref="SGD:S000004991" /translation="MEHVSKRSIGQFFKRKTSTVDGSKSQKCGTTNQLRKLLHKRRVQ KQAVPVESQYRIPGDFRDNQSVRVKNSMYNSSPSVTPSTHHINERYVRYDINTRPLVV VLAISIVFFGCLLVLKDIIIQSSENILSVSKWKIIGASFMGTPYTGLLTGLVGPLLSP FSAVSSWLSFIF" gene 542963..544978 /gene="LAP2" /locus_tag="YNL045W" mRNA 542963..544978 /gene="LAP2" /locus_tag="YNL045W" /product="bifunctional aminopeptidase/epoxide hydrolase" CDS 542963..544978 /gene="LAP2" /locus_tag="YNL045W" /EC_number="3.3.2.10" /experiment="EXISTENCE:direct assay:GO:0004177 aminopeptidase activity [PMID:10574934]" /experiment="EXISTENCE:direct assay:GO:0004301 epoxide hydrolase activity [PMID:10574934]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006629 lipid metabolic process [PMID:10574934]" /experiment="EXISTENCE:direct assay:GO:0030163 protein catabolic process [PMID:10574934]" /note="Leucyl aminopeptidase yscIV with epoxide hydrolase activity; metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; also known as leukotriene A4 hydrolase" /codon_start=1 /product="bifunctional aminopeptidase/epoxide hydrolase" /protein_id="DAA10500.1" /db_xref="SGD:S000004990" /translation="MFLLPFVIRHSSSIYLPTLRFRGLLTVISRNIHISTPHKMLPLS IEQRRPSRSPEYDQSTLSNYKDFAVLHTDLNLSVSFEKSAISGSVTFQLKKLHEGKNK SDELHLDTSYLDVQEVHIDGSKADFQIEQRKEPLGSRLVINNASCNDNFTLNIQFRTT DKCTALQWLNSKQTKGGKPYVFSQLEAIHARSLFPCFDTPSVKSTFTASIESPLPVVF SGIRIEDTSKDTNIYRFEQKVPIPAYLIGIASGDLSSAPIGPRSTVYTEPFRLKDCQW EFENDVEKFIQTAEKIIFEYEWGTYDILVNVDSYPYGGMESPNMTFATPTLIAHDRSN IDVIAHELAHSWSGNLVTNCSWNHFWLNEGWTVYLERRIIGAIHGEPTRHFSALIGWS DLQNSIDSMKDPERFSTLVQNLNDNTDPDDAFSTVPYEKGFNLLFHLETILGGKAEFD PFIRHYFKKFAKKSLDTFQFLDTLYEFYPEKKEILDSVDWETWLYKPGMPPRPHFITA LADNVYQLADKWVEMAQHLKTTEDFRSEFNAIDIKDFNSNQLVLFLETLTQNGHSNKK PKDFDWAKFPVASRALLDIYQDNIVKSQNAEVVFKMFKFQIFAKLQEEYKHLADWLGT VGRMKFVRPGYRLLNSVDRRLALATFDKFKDTYHPICKALVKQDLGL" gene 545268..545877 /gene="YIP3" /locus_tag="YNL044W" mRNA join(545268..545291,545371..545877) /gene="YIP3" /locus_tag="YNL044W" /product="Yip3p" CDS join(545268..545291,545371..545877) /gene="YIP3" /locus_tag="YNL044W" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16002643]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:16002643]" /experiment="EXISTENCE:direct assay:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:11157978]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]" /note="Protein localized to COPII vesicles; proposed to be involved in ER-to-Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p; integral membrane protein that localizes to the ER, the Golgi apparatus, transport vesicles and the peroxisome; two isoforms exist, a full-length Yip3L (Yip3 Long) and a shorter peroxisomal matrix isoform Yip3S (Yip3 Short)" /codon_start=1 /product="Yip3p" /protein_id="DAA10501.1" /db_xref="SGD:S000004989" /translation="MNQLGALAQVSRFTQNFSMENIKSEFQSLQSKLATLRTPQEFFN FKKISKPQNFGEVQSRVAYNLKYFSSNYGLIIGCLSIYTLLTNLLLLFVIVLVVAGIV GINKLKGEELVTPFGSFKTNQLYTGLVCVAVPIGFLASPISTLLWLIGASAVSVFGHA SLMEKPIETVFDEETV" rep_origin 546072..546170 /note="ARS1421; Autonomously Replicating Sequence" /db_xref="SGD:S000118389" repeat_region 546423..546714 /note="Ty3 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007138" repeat_region 546738..547077 /note="Ty3 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007139" gene 547094..547196 /locus_tag="YNCN0009W" tRNA join(547094..547129,547161..547196) /locus_tag="YNCN0009W" /product="tRNA-Pro" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Proline tRNA (tRNA-Pro), predicted by tRNAscan-SE analysis; target of K. lactis zymocin" /db_xref="SGD:S000006685" gene 547113..547370 /locus_tag="YNL042W-B" mRNA 547113..547370 /locus_tag="YNL042W-B" /product="hypothetical protein" CDS 547113..547370 /locus_tag="YNL042W-B" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10502.1" /db_xref="SGD:S000028850" /translation="MILALGDFLPKQEDKACERPWVQFPARPVIFFHHQGGIFLFSIN QPNLSCFSKLKEVNSLYVRVATYICQKNESRFRTNRLKGDQ" gene 548100..549290 /gene="BOP3" /locus_tag="YNL042W" mRNA 548100..549290 /gene="BOP3" /locus_tag="YNL042W" /product="Bop3p" CDS 548100..549290 /gene="BOP3" /locus_tag="YNL042W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0071406 cellular response to methylmercury [PMID:15796894]" /note="hypothetical protein; potential Cdc28p substrate; overproduction confers resistance to methylmercury" /codon_start=1 /product="Bop3p" /protein_id="DAA10503.1" /db_xref="SGD:S000004987" /translation="MSTFNSYSQPKESNDNSHNNVNKSKSLLDIIFGTNVSEWAFSEN ALMKAMDLKIEQEKTKQQYYKLENLNRSIELFKLASSSGLPINQIHKLFNTDHGVPAS SPMKAGGNQPHNNTEGTQSSENLPRLNGSMKSLKPLNMNTVSPTPMSRQPSPYKFPAS SSTGGISHSTVTNVQRRANSPARIGASAVAALNDNISIKEEDVARRIPSGTKSQESPL NKKPTSLHSRNLSLPIGKFTNPNIPSTMTSILSFNRDQQQPLSQPLPPPPQQQQDLHT HNLHTIPRKPGMVQKKHRRARSTSSFGVIDLSIIDEAKEKQVQRSPSPIHSNVSVALT SHDKPIESNMKEQPNMLQSVREGRQVHDDLDDRTCSESSSRNESPVRTITKDNSVGKI LNST" gene complement(549468..551987) /gene="COG6" /locus_tag="YNL041C" /gene_synonym="COD2" /gene_synonym="SEC37" mRNA complement(549468..551987) /gene="COG6" /locus_tag="YNL041C" /gene_synonym="COD2" /gene_synonym="SEC37" /product="Golgi transport complex subunit COG6" CDS complement(549468..551987) /gene="COG6" /locus_tag="YNL041C" /gene_synonym="COD2" /gene_synonym="SEC37" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0017119 Golgi transport complex [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:20065092]" /note="Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" /codon_start=1 /product="Golgi transport complex subunit COG6" /protein_id="DAA10504.1" /db_xref="SGD:S000004986" /translation="MDFVVDYQTYAMADTATPELPEPEPRLNLTSDAQSQPTGKLDLQ FKLPDLQRYSNNNATLPVDNDGAGSKDLHKKMTHYAMSSIDKIQLSNPSKQLGQNSQD EKLSQQESQNFTNYEPKNLDLSKLVSPSSGSNKNTTNLVLSNKLSKILNNYTLINYQA TVQLRKSLKVLEENKERLSLDEQKLMNPEYVGTLARRALRTDLESQLLKEHITVLEEF KPIIRRIKRLSSSVEKIQRTSEKLLSNETNEVPTNNVVLQEIDQYRLKAEQLKLKKKI LLSIRDRFTLNQVEDDVITNGTIDNIFFEVVKKVINIKDESSFLLTLPNLNAGNALIM GVNEILEKTNKKIFNYLIDFLYSFESSSNLLNDHGTTEQESLNIFRKSLVFLSSDLEL FNELLKRVTTLRSKSILDEFLSQFDMNSTTSKPIILSAHDPIRYIGDVLASVHSIIAN EADFVKSLFDFQDEDLKDTPISILQQNKTFLKGIDNKLLNDIIQSLSNSCRIRIEQIV RFEENPIINFEIVRLLKLYRVMFERKGIQDDSSIINNLKSLEDISKNRIIGYYEDYMK QTVMAETKNSSDDLLPPEWLSEYMNKLVELFEIYEKTHAAEDEESEDNKLLSSKNLQT IVEQPIKDVLLKQLQTSFPLAKKNEKEKASLLTIEINCFDLIKSRLQPFEGLFAQDDD SRKITIWVCDKLKEYTKQMLTLQIKFLFENTGLDLYSNLVNMIFPVDSVKDELDYDMY LALRDNSLMELDMVRKNVHDKLNYYLPQALTDVQGNLLFKLTSPMIADEICDECFKKL SLFYNIFRKLLIHLYPNKKDQVFEILNFSTDEFDMLIGIDH" gene complement(552478..552558) /locus_tag="YNL040C-A" mRNA complement(552478..552558) /locus_tag="YNL040C-A" /product="hypothetical protein" CDS complement(552478..552558) /locus_tag="YNL040C-A" /note="hypothetical protein; deletion confers sensitivity to osmotic stress" /codon_start=1 /product="hypothetical protein" /protein_id="DBA54443.1" /db_xref="SGD:S000350098" /translation="MPEQKANCSPNGNITVDSMIMSLGSS" gene 553380..554750 /locus_tag="YNL040W" mRNA 553380..554750 /locus_tag="YNL040W" /product="putative alanine--tRNA ligase" CDS 553380..554750 /locus_tag="YNL040W" /experiment="EXISTENCE:direct assay:GO:0002196 Ser-tRNA(Ala) deacylase activity [PMID:38869066]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043905 L-seryl-tRNA(Thr) hydrolase activity [PMID:38869066]" /experiment="EXISTENCE:genetic interaction:GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity [PMID:38869066]" /experiment="EXISTENCE:mutant phenotype:GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity [PMID:38869066]" /note="Ser-tRNA(Ala) hydrolase; hydrolyzes Ser-mischarged cytoplasmic and mitochondrial tRNAs; regulates translational fidelity based on Ala- and Thr-to-Ser misincorporation in the null mutant; trans-editing factor for alanyl- and threonyl-tRNA synthetases and seryl-tRNA synthetase (SerRS) via hydrolysis; null mutant displays decreased translation rate and increased readthrough of premature stop codons; (GFP)-fusion protein localizes to the cytoplasm; homologous to human trans-editing factor AARSD" /codon_start=1 /product="putative alanine--tRNA ligase" /protein_id="DAA10505.1" /db_xref="SGD:S000004985" /translation="MPTPMTPVKVGALACQRNSFLFDGFKTLVVSCEPTKNKKGEIEG YEIELQDTILFPEGGGQPSDSGFLKIVEGNRNSSKIEKILVSHVSRFGLHAKHHVNDY IEPGTTVEVAVDEQKRMDYMQQHTGQHLLSAILERNYKVDTVSWSMGGIITKKKPVLE PSDYFNYIELNRKLTLDEITNVSDEINQLIINFPQEIIVEERIGEETVDEVSTSKIPD DYDLSKGVLRTIHIGDIDSNPCCGTHLKCTSQIGSILILSNQSAVRGSNSRLYFMCGK RVSLYAKSVNKILLDSKNLLSCSETQISEKITRQTKQIQQLNKREQYWIKRLARTASE ELMNTLKASGKKRAYFMEEEYGTLELLLQIHKEVSNFLKDDTEGYEIILCGYERQTNT GSLLILSESGEKIANLAANLGSILQNLKGGGGKKGGKWQGKITSISNAEFAALSDYLS HDFASC" gene 555048..556832 /gene="BDP1" /locus_tag="YNL039W" /gene_synonym="TFC5" /gene_synonym="TFC7" mRNA 555048..556832 /gene="BDP1" /locus_tag="YNL039W" /gene_synonym="TFC5" /gene_synonym="TFC7" /product="transcription factor TFIIIB subunit BDP1" CDS 555048..556832 /gene="BDP1" /locus_tag="YNL039W" /gene_synonym="TFC5" /gene_synonym="TFC7" /experiment="EXISTENCE:direct assay:GO:0000126 transcription factor TFIIIB complex [PMID:1458536|PMID:7568218]" /experiment="EXISTENCE:direct assay:GO:0001156 TFIIIC-class transcription factor complex binding [PMID:12930823]" /experiment="EXISTENCE:direct assay:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:11387215]" /experiment="EXISTENCE:mutant phenotype:GO:0001112 DNA-templated transcription open complex formation [PMID:11387215]" /experiment="EXISTENCE:mutant phenotype:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:11387215]" /experiment="EXISTENCE:physical interaction:GO:0001156 TFIIIC-class transcription factor complex binding [PMID:12930823]" /note="Essential subunit of RNA polymerase III transcription factor (TFIIIB); TFIIIB is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs" /codon_start=1 /product="transcription factor TFIIIB subunit BDP1" /protein_id="DAA10506.1" /db_xref="SGD:S000004984" /translation="MSSIVNKSGTRFAPKVRQRRAATGGTPTPKPRTPQLFIPESKEI EEDNSDNDKGVDENETAIVEKPSLVGERSLEGFTLTGTNGHDNEIGDEGPIDASTQNP KADVIEDNVTLKPAPLQTHRDQKVPRSSRLASLSKDNESRPSFKPSFLDSSSNSNGTA RRLSTISNKLPKKIRLGSITENDMNLKTFKRHRVLGKPSSAKKPAGAHRISIVSKISP PTAMTDSLDRNEFSSETSTSREADENENYVISKVKDIPKKVRDGESAKYFIDEENFTM AELCKPNFPIGQISENFEKSKMAKKAKLEKRRHLRELRMRARQEFKPLHSLTKEEQEE EEEKRKEERDKLLNADIPESDRKAHTAIQLKLNPDGTMAIDEETMVVDRHKNASIENE YKEKVDENPFANLYNYGSYGRGSYTDPWTVEEMIKFYKALSMWGTDFNLISQLYPYRS RKQVKAKFVNEEKKRPILIELALRSKLPPNFDEYCCEIKKNIGTVADFNEKLIELQNE HKHHMKEIEEAKNTAKEEDQTAQRLNDANLNKKGSGGIMTNDLKVYRKTEVVLGTIDD LKRKKLKERNNDDNEDNEGSEEEPEIDQ" gene 557020..557783 /gene="GPI15" /locus_tag="YNL038W" mRNA join(557020..557610,557685..557783) /gene="GPI15" /locus_tag="YNL038W" /product="phosphatidylinositol N-acetylglucosaminyltransferase GPI15" CDS join(557020..557610,557685..557783) /gene="GPI15" /locus_tag="YNL038W" /EC_number="2.4.1.198" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:11746600]" /experiment="EXISTENCE:mutant phenotype:GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity [PMID:11746600]" /note="Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol" /codon_start=1 /product="phosphatidylinositol N-acetylglucosaminyltransferase GPI15" /protein_id="DAA10507.1" /db_xref="SGD:S000004983" /translation="MISKEYEFGKTSILNRKKYTLVIDEDKNGNFIRFTVLPVSNRKF KKVKQNGRVEINMGIQYHQIVLILLLNILFYVICLRSRFLEHINRTFEVTIARSFQIL IIMGLFALGTIILVRGPSVETVTIFKESGLQLSRVKGMVIFPQQWNRKFFEQVEFISN ERIIDVVINEGFCRGFRVIFYLAAIVRKSSTLKLLFPSNLPSIDDQRLIYNISRKYLS KQEKPLSRPKD" gene complement(557920..559002) /gene="IDH1" /locus_tag="YNL037C" mRNA complement(557920..559002) /gene="IDH1" /locus_tag="YNL037C" /product="isocitrate dehydrogenase (NAD(+)) IDH1" CDS complement(557920..559002) /gene="IDH1" /locus_tag="YNL037C" /EC_number="1.1.1.41" /experiment="EXISTENCE:direct assay:GO:0004449 isocitrate dehydrogenase (NAD+) activity [PMID:16884682]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:8626605]" /experiment="EXISTENCE:direct assay:GO:0006102 isocitrate metabolic process [PMID:16884682]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15692048]" /experiment="EXISTENCE:direct assay:GO:0045242 isocitrate dehydrogenase complex (NAD+) [PMID:16884682]" /note="Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle" /codon_start=1 /product="isocitrate dehydrogenase (NAD(+)) IDH1" /protein_id="DAA10508.1" /db_xref="SGD:S000004982" /translation="MLNRTIAKRTLATAAQAERTLPKKYGGRFTVTLIPGDGVGKEIT DSVRTIFEAENIPIDWETINIKQTDHKEGVYEAVESLKRNKIGLKGLWHTPADQTGHG SLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVE SLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYP DIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRD YAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGK HTTRDIGGSSSTTDFTNEIINKLSTM" gene 559814..560479 /gene="NCE103" /locus_tag="YNL036W" /gene_synonym="NCE3" mRNA 559814..560479 /gene="NCE103" /locus_tag="YNL036W" /gene_synonym="NCE3" /product="carbonate dehydratase NCE103" CDS 559814..560479 /gene="NCE103" /locus_tag="YNL036W" /gene_synonym="NCE3" /EC_number="4.2.1.1" /experiment="EXISTENCE:direct assay:GO:0004089 carbonate dehydratase activity [PMID:15813743|PMID:15096093]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:15096093]" /experiment="EXISTENCE:mutant phenotype:GO:0071244 cellular response to carbon dioxide [PMID:22253597]" /note="Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress" /codon_start=1 /product="carbonate dehydratase NCE103" /protein_id="DAA10509.1" /db_xref="SGD:S000004981" /translation="MSATESSSIFTLSHNSNLQDILAANAKWASQMNNIQPTLFPDHN AKGQSPHTLFIGCSDSRYNENCLGVLPGEVFTWKNVANICHSEDLTLKATLEFAIICL KVNKVIICGHTDCGGIKTCLTNQREALPKVNCSHLYKYLDDIDTMYHEESQNLIHLKT QREKSHYLSHCNVKRQFNRIIENPTVQTAVQNGELQVYGLLYNVEDGLLQTVSTYTKV TPK" gene complement(560693..560765) /locus_tag="YNCN0010C" tRNA complement(560693..560765) /locus_tag="YNCN0010C" /product="tRNA-Thr" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Threonine tRNA (tRNA-Thr), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006745" rep_origin 561111..561388 /note="ARS1422; Autonomously Replicating Sequence" /db_xref="SGD:S000118390" repeat_region 561607..561977 /note="Ty4 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007141" repeat_region complement(562033..562364) /note="Ty2 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007131" mobile_element complement(562364..567660) /note="YNLCTy2-1; Ty2 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats; mutated in S288C" /mobile_element_type="retrotransposon:YNLCTy2-1" /db_xref="SGD:S000007135" repeat_region complement(567660..567992) /note="Ty2 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007132" gene 568115..568217 /locus_tag="YNCN0011W" tRNA join(568115..568150,568182..568217) /locus_tag="YNCN0011W" /product="tRNA-Pro" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Proline tRNA (tRNA-Pro), predicted by tRNAscan-SE analysis; target of K. lactis zymocin" /db_xref="SGD:S000006686" rep_origin 568219..568524 /note="ARS1423; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay" /db_xref="SGD:S000130143" gene complement(568522..569691) /locus_tag="YNL035C" mRNA complement(568522..569691) /locus_tag="YNL035C" /product="hypothetical protein" CDS complement(568522..569691) /locus_tag="YNL035C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /note="Nuclear hypothetical protein; relocalizes to the cytosol in response to hypoxia; contains WD-40 domains; not an essential gene; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10510.1" /db_xref="SGD:S000004980" /translation="MASYSLVESNSFGSENWCLKLQPSYKHGLLTGLSNGEIRLLDWS TGKSVQKIKASETAINDMKVIGSDFSAGHLVSSASIDAVKVFDIRTNDRIAQIQNEAN SPFISLDSRHGLLACGTELQGIDAAVYIYDIRKWDTPLRSLIDSHHDDVTCIKFHPSD VNILLSGSTDGYTNIYDLKQDEEEDALHQVINYASIHSCGWLSPKRIFTLSHMETFAI HELNDKSDELKEPQPLDFGDVREIWNCDYVVDIYPGLIATGKTQENCGELCLLPFKDE KVDTENGIVIPHAHGDEVVRDIFIPAQHSNMLYSCGEDGCVKIWENKQGPLDIPENFW DYSKKMNVLGDDDREGSINLDEPLIIQKESVSTRPRKEKHKKAKKHSMKSRFKPY" gene complement(569867..569940) /locus_tag="YNCN0012C" tRNA complement(569867..569940) /locus_tag="YNCN0012C" /product="tRNA-Ile" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Isoleucine tRNA (tRNA-Ile), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006609" gene 570477..572315 /locus_tag="YNL034W" mRNA 570477..572315 /locus_tag="YNL034W" /product="hypothetical protein" CDS 570477..572315 /locus_tag="YNL034W" /experiment="EXISTENCE:mutant phenotype:GO:0043935 sexual sporulation resulting in formation of a cellular spore [PMID:36441813]" /note="Protein required for sporulation; induced during meiosis and sporulation; gene is a member of Centroid, a centromere-linked gene family; not an essential gene; YNL034W has a paralog, YNL018C, that arose from a segmental duplication" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10511.1" /db_xref="SGD:S000004979" /translation="MSTSFQEFKAFCNKVGLDFQWLNLQSSKSVPESGSSEGFSAVSD TVQENIRPATEPLNVNQSKDPVSNFFYDVKNAPLWNVYKRNHSGHSSTEACSGVSSGQ ASKNIPEAMVKETVLSNHDNVTIINELLPTSSAMHQEESTAMTTSYLLSHSVNDSCNV MLSSSSHNRAMLPPSLVQRNNATTSPTTDSASENNESVPSLTSSVSTSSSVYSSWNPP HSPHISSFPDGNFASLNAEVTCFDFRRTKDSRTKETNESIIPTEIYCPINSTDHHKHY PSQKSKQDACAPAPRNQNISCSVGSAAEFSQSNHTLTTVVPSYMQQYLDRPQNWFESK MGKYCPLFLRSTKNIDYDSLEFKFERKMIAVQYLLLDEQSEPRRYYNPSNKSIPFWKR PFNFDTMPSYDQLMEEAECRFYSYQYKYEGFQRIEPYSIFCPWKNTQREIDLVLDHIH FSLDVGEKKSLNRKGNITLDTLDSKVDPNIQIKPYQIFPSNNLVYEGLPHPAEQSLIL SPGTSLIERAFQALIDICKESIPPSNDCTTRNHNSAPQLTVPEPSKPCRLLLVRESRT ATELETNKKLWLHSQRRNIEVTVPMHPSEHGTKSRLRKWLSTFVHQ" gene 572999..573853 /locus_tag="YNL033W" mRNA 572999..573853 /locus_tag="YNL033W" /product="hypothetical protein" CDS 572999..573853 /locus_tag="YNL033W" /note="hypothetical protein; YNL033W has a paralog, YNL019C, that arose from a segmental duplication" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10512.1" /db_xref="SGD:S000004978" /translation="MLYSRESRTTVLFLALVTSLTVLCHSVDVTTVFTTSTITEITTV TAAPQPQNKAETALNTATNIIQTMQFLFNCAPFKWKGPLKITSCALNFIVLLLTAWGY LLKYLQENKLNSDADMEKMVGLGFGEMVGRIFGKGVGKAFTKMDITQKLVYPFEGSNR QKCLLMTVGENSIVPFHDLFTEICFDQYTLDSLSHHNHGSISILDAGSVSALGFADIS SKMPSVSELYTLFGDYTIEVLGGITKLASTLNREDWQGERNGFAVLSRDRPNQTLLSV HMYSSSLL" gene 574506..575351 /gene="SIW14" /locus_tag="YNL032W" /gene_synonym="OCA3" mRNA 574506..575351 /gene="SIW14" /locus_tag="YNL032W" /gene_synonym="OCA3" /product="putative tyrosine protein phosphatase SIW14" CDS 574506..575351 /gene="SIW14" /locus_tag="YNL032W" /gene_synonym="OCA3" /EC_number="3.6.1.52" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity [PMID:26828065|PMID:29540476]" /experiment="EXISTENCE:direct assay:GO:0052847 inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity [PMID:29540476]" /experiment="EXISTENCE:direct assay:GO:0106211 inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity [PMID:29540476]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:15020461]" /experiment="EXISTENCE:mutant phenotype:GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity [PMID:29540476|PMID:26828065]" /experiment="EXISTENCE:mutant phenotype:GO:0052847 inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity [PMID:29540476]" /experiment="EXISTENCE:mutant phenotype:GO:0071543 diphosphoinositol polyphosphate metabolic process [PMID:26828065]" /experiment="EXISTENCE:mutant phenotype:GO:0106211 inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity [PMID:29540476]" /note="Inositol phosphatase involved in inositol pyrophosphate metabolism; hydrolyzes the beta-phosphate from the 5-diphosphate group of PP-InsPs including: 5PP-IP5 (IP7), 1,5PP-IP4 (IP8) and 5-PP-InsP4; functions as an anti-prion (anti-[PSI]) component; member of the atypical dual-specificity subgroup of the protein tyrosine-phosphatase (PTP) superfamily; localizes to the cytoplasm" /codon_start=1 /product="putative tyrosine protein phosphatase SIW14" /protein_id="DAA10513.1" /db_xref="SGD:S000004977" /translation="MGLYQAKNDEGSDPKSSSKIDDLIENEAEIIRLIKEDGKLLIDN GDGRDIHNIIQEDKLLSVEFNEVLKRFHGEEKSDIPRKEFDEDEDDGYDSNEHHQKTI EVMNTLNHVINKEVIPPENFSHVVGEIYRSSFPRQENFSFLHERLKLKSILVLIPEEY PQENLNFLKLTGIKLYQVGMSGNKEPFVNIPSHLLTKALEIVLNPANQPILIHCNRGK HRTGCLIGCIRKLQNWSLTMIFDEYRRFAFPKARALDQQFIEMYDDDEIKRIASKNNW LPLQW" gene complement(575640..576050) /gene="HHT2" /locus_tag="YNL031C" mRNA complement(575640..576050) /gene="HHT2" /locus_tag="YNL031C" /product="histone H3" CDS complement(575640..576050) /gene="HHT2" /locus_tag="YNL031C" /experiment="EXISTENCE:direct assay:GO:0008823 cupric reductase (NADH) activity [PMID:32631887]" /experiment="EXISTENCE:mutant phenotype:GO:0006878 intracellular copper ion homeostasis [PMID:32631887]" /experiment="EXISTENCE:mutant phenotype:GO:0008823 cupric reductase (NADH) activity [PMID:32631887]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:32631887]" /note="Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage" /codon_start=1 /product="histone H3" /protein_id="DAA10514.1" /db_xref="SGD:S000004976" /translation="MARTKQTARKSTGGKAPRKQLASKAARKSAPSTGGVKKPHRYKP GTVALREIRRFQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQESVEAYLV SLFEDTNLAAIHAKRVTIQKKDIKLARRLRGERS" gene 576727..577038 /gene="HHF2" /locus_tag="YNL030W" mRNA 576727..577038 /gene="HHF2" /locus_tag="YNL030W" /product="histone H4" CDS 576727..577038 /gene="HHF2" /locus_tag="YNL030W" /note="Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity" /codon_start=1 /product="histone H4" /protein_id="DAA10515.1" /db_xref="SGD:S000004975" /translation="MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGV KRISGLIYEEVRAVLKSFLESVIRDSVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFG G" gene complement(577205..578773) /gene="KTR5" /locus_tag="YNL029C" mRNA complement(577205..578773) /gene="KTR5" /locus_tag="YNL029C" /product="putative mannosyltransferase" CDS complement(577205..578773) /gene="KTR5" /locus_tag="YNL029C" /experiment="EXISTENCE:curator inference:GO:0097502 mannosylation [PMID:9090056]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR5 has a paralog, KTR7, that arose from the whole genome duplication" /codon_start=1 /product="putative mannosyltransferase" /protein_id="DAA10516.1" /db_xref="SGD:S000004974" /translation="MLLIRRTINAFLGCIHCNLTATCILIAFVITMYVVLVSEPASVD GTMGNFLPFSKMDLATKRDRPFYSNCVNTQDYLLNPSYIKQNASFVMLTRNGELEDVI KTINSIEEHFNQWFHYPYVFLNDQPFEEDFKAKVRDVTVGALVEFGTIDEISWNFPSD VKDTFEFYNAIEDQGDRSILYGNLESYHKMCRFYSGLFYKHPLVQKYEWYWRLEPDVE FFCDITYDPFLEMLRTNKKYGFTIIIPELYWTVPNLFRHTKSFISQKGVTLGSLWKLF TKDYDIFESDDPELRDWINYDFQAKAKISEKIAIEQLLKKGDDFQQINDDKEGIMNLI HKARSRKHIVEDKFFNEEYNLCHFWSNFEIARLSVFDNDIYNSFFQYLEKSGGFWKER WGDAPVHSIGLSLTLDLDDVHYFRDIGYRHSTIQHCPHNAMGNEEFSYLASDSKFKRK NAAYDEGREFGCGCRCRCPKKKREIEDSMGFCVNIWVNLLNQQRGHERHVEALNGNEM EEHIREDYLRQFGN" gene 579580..581616 /gene="CRZ1" /locus_tag="YNL027W" /gene_synonym="HAL8" /gene_synonym="TCN1" mRNA 579580..581616 /gene="CRZ1" /locus_tag="YNL027W" /gene_synonym="HAL8" /gene_synonym="TCN1" /product="DNA-binding transcription factor CRZ1" CDS 579580..581616 /gene="CRZ1" /locus_tag="YNL027W" /gene_synonym="HAL8" /gene_synonym="TCN1" /experiment="EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:11523797]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:20412803|PMID:11523797]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10197980]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10197980]" /experiment="EXISTENCE:direct assay:GO:0010765 positive regulation of sodium ion transport [PMID:11523797]" /experiment="EXISTENCE:direct assay:GO:0030007 intracellular potassium ion homeostasis [PMID:20412803]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20412803|PMID:11523797]" /experiment="EXISTENCE:direct assay:GO:0071483 cellular response to blue light [PMID:23335962]" /experiment="EXISTENCE:genetic interaction:GO:0006031 chitin biosynthetic process [PMID:21343301]" /experiment="EXISTENCE:genetic interaction:GO:0030007 intracellular potassium ion homeostasis [PMID:20412803]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20412803|PMID:9407035|PMID:25258318]" /experiment="EXISTENCE:genetic interaction:GO:0050801 monoatomic ion homeostasis [PMID:9407035]" /experiment="EXISTENCE:genetic interaction:GO:0071277 cellular response to calcium ion [PMID:9407035]" /experiment="EXISTENCE:mutant phenotype:GO:0030007 intracellular potassium ion homeostasis [PMID:20412803]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9407035|PMID:9407036|PMID:9559673|PMID:20412803|PMID :15299026|PMID:11523797]" /experiment="EXISTENCE:mutant phenotype:GO:0050801 monoatomic ion homeostasis [PMID:9407035]" /experiment="EXISTENCE:mutant phenotype:GO:0071277 cellular response to calcium ion [PMID:9407036|PMID:11523797|PMID:9407035]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:9407035|PMID:9407036]" /experiment="EXISTENCE:mutant phenotype:GO:0071469 cellular response to alkaline pH [PMID:15299026|PMID:11523797]" /experiment="EXISTENCE:mutant phenotype:GO:0071475 cellular hyperosmotic salinity response [PMID:11523797|PMID:9407035|PMID:9559673]" /experiment="EXISTENCE:mutant phenotype:GO:2001040 positive regulation of cellular response to drug [PMID:17056742]" /note="Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress; can be activated in stochastic pulses of nuclear localization in response to calcium" /codon_start=1 /product="DNA-binding transcription factor CRZ1" /protein_id="DAA10517.1" /db_xref="SGD:S000004972" /translation="MSFSNGNMASYMTSSNGEEQSINNKNDIDDNSAYRRNNFRNSSN SGSHTFQLSDLDLDVDMRMDSANSSEKISKNLSSGIPDSFDSNVNSLLSPSSGSYSAD LNYQSLYKPDLPQQQLQQQQLQQQQQQQQQQQQQQQKQTPTLKVEQSDTFQWDDILTP ADNQHRPSLTNQFLSPRSNYDGTTRSSGIDSNYSDTESNYHTPYLYPQDLVSSPAMSH LTANNDDFDDLLSVASMNSNYLLPVNSHGYKHISNLDELDDLLSLTYSDNNLLSASNN SDFNNSNNGIINTADTQNSTIAINKSKVGTNQKMLLTIPTSSTPSPSTHAAPVTPIIS IQEFNEGHFPVKNEDDGTLQLKVRDNESYSATNNNNLLRPDDNDYNNEALSDIDRSFE DIINGRKLKLKKSRRRSSQTSNNSFTSRRSSRSRSISPDEKAKSISANREKLLEMADL LPSSENDNNRERYDNDSKTSYNTINSSNFNEDNNNNNLLTSKPKIESGIVNIKNELDD TSKDLGILLDIDSLGQFEQKVGFKNDDNHENNDNGTFSVKKNDNLEKLDSVTNNRKNP ANFACDVCGKKFTRPYNLKSHLRTHTNERPFICSICGKAFARQHDRKRHEDLHTGKKR YVCGGKLKDGKPWGCGKKFARSDALGRHFKTESGRRCITPLYEEARQEKSGQES" gene 581920..583374 /gene="SAM50" /locus_tag="YNL026W" /gene_synonym="OMP85" /gene_synonym="TOB55" mRNA 581920..583374 /gene="SAM50" /locus_tag="YNL026W" /gene_synonym="OMP85" /gene_synonym="TOB55" /product="SAM complex subunit SAM50" CDS 581920..583374 /gene="SAM50" /locus_tag="YNL026W" /gene_synonym="OMP85" /gene_synonym="TOB55" /experiment="EXISTENCE:direct assay:GO:0001401 SAM complex [PMID:14570913]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14690591|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:14699090|PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:14685243]" /experiment="EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:18039934|PMID:14570913]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:14570913|PMID:14685243]" /note="Component of the Sorting and Assembly Machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85" /codon_start=1 /product="SAM complex subunit SAM50" /protein_id="DAA10518.1" /db_xref="SGD:S000004971" /translation="MTSSSGVDNEISLDSPMPIFNESSTLKPIRVAGVVTTGTDHIDP SVLQAYLDDTIMKSITLGQLVKNADVLNKRLCQHHIALNAKQSFHFQGNTYISDEKET HDVVPLMEVVSQLDILPPKTFTAKTGTNFGNDNDAEAYLQFEKLIDKKYLKLPTRVNL EILRGTKIHSSFLFNSYSSLSPQSILNLKVFSQFYNWNTNKGLDIGQRGARLSLRYEP LFLHKLLHNPHSNESPTLFHEWFLETCWRSTKICSQGTSAPYMYSGTMLSQAGDQLRT ILGHTFVLDKRDHIMCPTKGSMLKWSNELSPGKHLKTQLELNSVKSWMNDDFITFSTT IKTGYLKNLSSQQSLPVHICDKFQSGGPSDIRGFQTFGLGPRDLYDAVGGDAFVSYGL SVFSRLPWKKVEKSNFRLHWFFNGGKLVNHDNTSLGNCIGQLSKEHSTSTGIGLVLRH PMARFELNFTLPITAHENDLIRKGFQFGLGLAFL" gene complement(584320..585291) /gene="SSN8" /locus_tag="YNL025C" /gene_synonym="CNC1" /gene_synonym="GIG3" /gene_synonym="NUT9" /gene_synonym="RYE2" /gene_synonym="SRB11" /gene_synonym="UME3" mRNA complement(584320..585291) /gene="SSN8" /locus_tag="YNL025C" /gene_synonym="CNC1" /gene_synonym="GIG3" /gene_synonym="NUT9" /gene_synonym="RYE2" /gene_synonym="SRB11" /gene_synonym="UME3" /product="cyclin-dependent protein serine/threonine kinase regulator SSN8" CDS complement(584320..585291) /gene="SSN8" /locus_tag="YNL025C" /gene_synonym="CNC1" /gene_synonym="GIG3" /gene_synonym="NUT9" /gene_synonym="RYE2" /gene_synonym="SRB11" /gene_synonym="UME3" /experiment="EXISTENCE:direct assay:GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding [PMID:23447536]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:7877695]" /experiment="EXISTENCE:direct assay:GO:0016592 mediator complex [PMID:11383511|PMID:12200444]" /experiment="EXISTENCE:direct assay:GO:0034605 cellular response to heat [PMID:23447536]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:14749387]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16109375]" /experiment="EXISTENCE:mutant phenotype:GO:0000411 positive regulation of transcription by galactose [PMID:15601835]" /experiment="EXISTENCE:mutant phenotype:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:7732022]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12455972]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:12455972]" /note="Cyclin-like component of RNA polymerase II holoenzyme; involved in phosphorylation of RNAPII C-terminal domain; forms kinase-cyclin pair in RNAPII holoenzyme with Ssn3p; needed for entry into and execution of meiotic program; involved in glucose repression, telomere maintenance; degraded in response to nitrogen starvation, and also to oxidative stress, but in different cellular compartments, and with different cellular outcomes; 35% identical to human cyclin C" /codon_start=1 /product="cyclin-dependent protein serine/threonine kinase regulator SSN8" /protein_id="DAA10519.1" /db_xref="SGD:S000004970" /translation="MSGSFWTSTQRHHWQYTKASLAKERQKLWLLECQLFPQGLNIVM DSKQNGIEQSITKNIPITHRDLHYDKDYNLRIYCYFLIMKLGRRLNIRQYALATAHIY LSRFLIKASVREINLYMLVTTCVYLACKVEECPQYIRTLVSEARTLWPEFIPPDPTKV TEFEFYLLEELESYLIVHHPYQSLKQIVQVLKQPPFQITLSSDDLQNCWSLINDSYIN DVHLLYPPHIIAVACLFITISIHGKPTKGSSLASAASEAIRDPKNSSSPVQIAFNRFM AESLVDLEEVMDTIQEQITLYDHWDKYHEQWIKFLLHTLYLRPASAI" gene 585587..585926 /gene="NME1" /locus_tag="YNCN0013W" ncRNA 585587..585926 /ncRNA_class="RNase_MRP_RNA" /gene="NME1" /locus_tag="YNCN0013W" /product="NME1" /experiment="EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:1398074]" /experiment="EXISTENCE:direct assay:GO:0006364 rRNA processing [PMID:8602511]" /experiment="EXISTENCE:mutant phenotype:GO:0000171 ribonuclease MRP activity [PMID:8290578|PMID:8602511|PMID:8247008]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:8247008|PMID:8290578]" /experiment="EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:22977255]" /experiment="EXISTENCE:mutant phenotype:GO:0045787 positive regulation of cell cycle [PMID:12136008]" /note="RNA component of RNase MRP; RNase MRP cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; human ortholog is implicated in cartilage-hair hypoplasia (CHH)" /db_xref="SGD:S000007436" gene 586090..586175 /gene="SNR66" /locus_tag="YNCN0014W" ncRNA 586090..586175 /ncRNA_class="snoRNA" /gene="SNR66" /locus_tag="YNCN0014W" /product="SNR66" /experiment="EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]" /experiment="EXISTENCE:curator inference:GO:0031428 box C/D methylation guide snoRNP complex [PMID:10024243]" /experiment="EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]" /experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]" /note="C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position U2417" /db_xref="SGD:S000006457" gene complement(586602..586820) /gene="KSH1" /locus_tag="YNL024C-A" mRNA complement(586602..586820) /gene="KSH1" /locus_tag="YNL024C-A" /product="Ksh1p" CDS complement(586602..586820) /gene="KSH1" /locus_tag="YNL024C-A" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:19942856]" /note="Essential protein suggested to function early in the secretory pathway; inviability is suppressed by overexpression of Golgi protein Tvp23p; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and cytosol respectively; ortholog of human Kish" /codon_start=1 /product="Ksh1p" /protein_id="DAA10520.1" /db_xref="SGD:S000028698" /translation="MSALFNFRSLLQVILLLICSCSYVHGQWPSLLDRYKNHEVLGAF WKMARVGERASPYVSLACILMAISQFNS" gene complement(587107..587847) /gene="EFM6" /locus_tag="YNL024C" mRNA complement(587107..587847) /gene="EFM6" /locus_tag="YNL024C" /product="putative protein-lysine N-methyltransferase" CDS complement(587107..587847) /gene="EFM6" /locus_tag="YNL024C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Putative S-adenosylmethionine-dependent lysine methyltransferase; responsible for modifying Lys-390 in translational elongation factor EF-1 alpha (eEF1A); has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /codon_start=1 /product="putative protein-lysine N-methyltransferase" /protein_id="DAA10521.1" /db_xref="SGD:S000004969" /translation="MESIFGGFGDLVVPRPKEHLGQTDLSFGGKLLPALKICEDGGES GCGGKVWIAGELLCEYILEKSVDHLLSKTVNGTKQFKKVLELGSGTGLVGLCVGLLEK NTFHDGTKVYVTDIDKLIPLLKRNIELDEVQYEVLARELWWGEPLSADFSPQEGAMQA NNVDLVLAADCVYLEEAFPLLEKTLLDLTHCINPPVILMAYKKRRKADKHFFNKIKRN FDVLEITDFSKFEHYLKERTHLFQLIRK" gene complement(588263..591160) /gene="FAP1" /locus_tag="YNL023C" mRNA complement(588263..591160) /gene="FAP1" /locus_tag="YNL023C" /product="Fap1p" CDS complement(588263..591160) /gene="FAP1" /locus_tag="YNL023C" /experiment="EXISTENCE:direct assay:GO:0005515 protein binding [PMID:36113412]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:36113412|PMID:10998178]" /experiment="EXISTENCE:direct assay:GO:0070651 nonfunctional rRNA decay [PMID:36113412]" /note="Cytoplasmic RING-finger E3 Ub-ligase and sensor of stalled ribosomes; binds to Fpr1p and Smu2p, and triggers K63-linked polyubiquitination of monoubiquitinated 40S subunit Rps3p, from decoding-defective ribosomes, followed by dissociation of the 80S ribosomes and non-functional rRNA decay (NRD) of 18S rRNA; confers rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus in rapamycin-treated cells; ortholog of D. melanogaster shuttle craft and human NFX1" /codon_start=1 /product="Fap1p" /protein_id="DAA10522.1" /db_xref="SGD:S000004968" /translation="MTEHESLGLEQNQDGGDTYRHHNLSDGCISSVEDANEQPSSYEE ESDDDMQYYERAIQEISSGDSYVCMICTVEMDYTCQMFACKRCYRVFDYGCIREWALK STEKTVDRIWKCPNCYYVSKRVPVKNRPTCWCGKVVNPDPNPLDPNSCGQTCNASTCM HGCSKICHLGPHPECTRMVEIMCHCGKHSKSIFCYQSKVMKKNFNCQEVCGLPLSCSI HTCKKKCHPGLCGPCPEMIISKDSPKKQIKCYCGNHTRANIKCSETKFPKSGKSSKDE NGNRWIGVFACADNRVVDYSCRKHSFIESCISPPTINGEKACPFLPSSLKTCPCGRTA LEELTKPRKHCDDPIPTCDSRCGKPLKCGKHSCPFTCHDKACMEPCLQIDSVKCACEQ STFSVPCGFQGRPRCNIKCESLMSCRRHRCTDRCCSGRPSAIRRKKNLFRTQDLLDES LVEAKHICLKPCNLTLSCGIHKCQRKCHPGKCPPCLESDSNDLVCPCGNTVVPAPVRC GTKLPTCNHPCIKVVRGESTCGHKPMPHTCHSLDVSCPPCTETVFKPCKCGKKTKVRT VCFQTDVSCGIKCGIPLSYCYHTCQKTCHLPGNCQKVCKQTCGQKRLNCNHECPKPCH GKTECPDLPCATLVKIYCKCGRIKKSVTCGAKSDRVSVTESSVLDCNEECEALKRLKE LKEAFGIKEETNNFTSNELDALKKLVSVATTFEELQLPFTEAALSVYSKQERWCSQIE AILNKLMDDKTRSSLHFKPMRPPQRHFIRELAKAYGLYSESQDREPMRSVFIKKEDNG ASNKPVLSLAEAYPLYESFKQLQKERKAQEFQARTTAKLINFEVQDTEPKVEVAKKNG FLVQNLVAGNTAEDLRRFFEPHLKHTLVVNPQYLILDDGKTALVYPENYETASVNTER DMELLVGHFDFMAKEAFLADSISLCSTEEELERRLDTPVIQEDSPVMDNNT" gene complement(591427..592899) /gene="RCM1" /locus_tag="YNL022C" mRNA complement(591427..592899) /gene="RCM1" /locus_tag="YNL022C" /product="rRNA (cytosine-C5-)-methyltransferase RCM1" CDS complement(591427..592899) /gene="RCM1" /locus_tag="YNL022C" /EC_number="2.1.1.311" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10649453]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:23913415]" /experiment="EXISTENCE:direct assay:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]" /experiment="EXISTENCE:direct assay:GO:0070475 rRNA base methylation [PMID:23913415]" /experiment="EXISTENCE:genetic interaction:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]" /experiment="EXISTENCE:genetic interaction:GO:0070475 rRNA base methylation [PMID:23913415]" /experiment="EXISTENCE:mutant phenotype:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]" /experiment="EXISTENCE:mutant phenotype:GO:0070475 rRNA base methylation [PMID:23913415]" /note="rRNA m5C methyltransferase; methylates cytosine at position 2278 of 25S rRNA while Nop2p methylates cytosine at position 2870; contains seven beta-strand methyltransferase motif; localized to the nucleolus; interacts with Trm112p; homolog of NSUN5A, a human gene which is deleted in Williams-Beuren Syndrome" /codon_start=1 /product="rRNA (cytosine-C5-)-methyltransferase RCM1" /protein_id="DAA10523.1" /db_xref="SGD:S000004967" /translation="MNFYRDATWVLEDIEKEAAKERISGSMQTLVLKSCKRYKLKSNP KHIYAVLDSCWKYKPYLEKVMKKAHILEDIPKKKGKPLFSRLTLLLLCHDLLLSKQKR IQMGKHPIKDYVLKFKSPLHSEMVKLKLKLKVRELSELVLSEDISNDLPPVRWIRINP LKCHPNGETEPVLAELRKKFTLKVDKWSELVPGSIYYDEFIPNLFGIHPSDKITAHEL YKHGKIIIQDRASCFPAHILNPGPSDIVIDSCSAPGNKTTHTASYIYPEPPKDNNTRI YAFEKDPERAKVLQKMIKIAGCSPNISVNVGDFTKLATPEKYKDVTCFIVDPSCSGSG IFGRKFFDSFNRRKIDDKDDDGGIVPDEQEEFIAKEELQTRLAKLSSFQFQMVKHAMS FPAAKKIVYSTCSIHAEENERVVIDLLLDKSVREWGWKVAPKREVIPSWPRRGKVEEF EEVFRDGVTYDPQQLAEGCIRALPKSDGGIGFFAVCFERD" gene 593227..595347 /gene="HDA1" /locus_tag="YNL021W" mRNA 593227..595347 /gene="HDA1" /locus_tag="YNL021W" /product="histone deacetylase HDA1" CDS 593227..595347 /gene="HDA1" /locus_tag="YNL021W" /EC_number="3.5.1.98" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:16415367]" /experiment="EXISTENCE:direct assay:GO:0004407 histone deacetylase activity [PMID:19573535]" /experiment="EXISTENCE:direct assay:GO:0070823 HDA1 complex [PMID:8663039|PMID:11287668|PMID:8962081]" /experiment="EXISTENCE:genetic interaction:GO:0010621 negative regulation of transcription by transcription factor localization [PMID:17974563]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17121596|PMID:11172717]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17706600]" /experiment="EXISTENCE:physical interaction:GO:0070823 HDA1 complex [PMID:11287668]" /note="Catalytic subunit of class II HDA1 histone deacetylase complex; role in azole resistance via Hsp90p, and in heat shock response; Hda1p interacts with Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation; the HDA1 histone deacetylase complex regulates aging through trehalose metabolism" /codon_start=1 /product="histone deacetylase HDA1" /protein_id="DAA10524.1" /db_xref="SGD:S000004966" /translation="MDSVMVKKEVLENPDHDLKRKLEENKEEENSLSTTSKSKRQVIV PVCMPKIHYSPLKTGLCYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRIYKILAENGL INDPTLSGVDDLGDLMLKIPVRAATSEEILEVHTKEHLEFIESTEKMSREELLKETEK GDSVYFNNDSYASARLPCGGAIEACKAVVEGRVKNSLAVVRPPGHHAEPQAAGGFCLF SNVAVAAKNILKNYPESVRRIMILDWDIHHGNGTQKSFYQDDQVLYVSLHRFEMGKYY PGTIQGQYDQTGEGKGEGFNCNITWPVGGVGDAEYMWAFEQVVMPMGREFKPDLVIIS SGFDAADGDTIGQCHVTPSCYGHMTHMLKSLARGNLCVVLEGGYNLDAIARSALSVAK VLIGEPPDELPDPLSDPKPEVIEMIDKVIRLQSKYWNCFRRRHANSGCNFNEPINDSI ISKNFPLQKAIRQQQQHYLSDEFNFVTLPLVSMDLPDNTVLCTPNISESNTIIIVVHD TSDIWAKRNVISGTIDLSSSVIIDNSLDFIKWGLDRKYGIIDVNIPLTLFEPDNYSGM ITSQEVLIYLWDNYIKYFPSVAKIAFIGIGDSYSGIVHLLGHRDTRAVTKTVINFLGD KQLKPLVPLVDETLSEWYFKNSLIFSNNSHQCWKENESRKPRKKFGRVLRCDTDGLNN IIEERFEEATDFILDSFEEWSDEE" gene complement(595623..597539) /gene="ARK1" /locus_tag="YNL020C" mRNA complement(595623..597539) /gene="ARK1" /locus_tag="YNL020C" /product="serine/threonine protein kinase ARK1" CDS complement(595623..597539) /gene="ARK1" /locus_tag="YNL020C" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:17978096]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:10087264]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:2000369 regulation of clathrin-dependent endocytosis [PMID:12956961]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:10087264]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:10087264]" /experiment="EXISTENCE:mutant phenotype:GO:2000369 regulation of clathrin-dependent endocytosis [PMID:12956961]" /note="Ser/Thr protein kinase; phosphorylates Pan1p-Sla1p-End3p protein complex subunits, Pan1p and Sla1p; involved in regulation of the cortical actin cytoskeleton and endocytosis; functional overlap with PRK1" /codon_start=1 /product="serine/threonine protein kinase ARK1" /protein_id="DAA10525.1" /db_xref="SGD:S000004965" /translation="MNQPQIGTYNVGTQLTVGSHQVEIIKYLTSGGFAQVYSALINPP DPHSNSSVACLKRVIVPDKPSLNTLRAEVDAMRLLKNNRYVVSYIDSHAAKAMLHNGS YEVFVLMEYCERGGLIDFMNTRLQNRLHEFEILQIMSQVTQGVAAMHALQPPLIHRDI KIENVLISANNEYKLCDFGSVCGIIRPPRNSQELSYVQQDILKNTTAQYRSPEMIDTF RGLPIDEKSDIWALGIFLYKLCYYTTPFEKGGDLAILSGKFEFPLYPNYSEQLKGLIR DILVQDPRHRPNVYQLLKRISIMQNVPCPINDIQVVQAPSSHLNLTELHQLSATQNIL SLNSPTTMENTMPNATFQISMADNTTTAQMHPNRKPSQIAYDASFSNSAKGSQPLFDK SQNMYHALDPPLVEPLASSVSNNDNELKANSATKLKQAIVSEAHTFRQNNSIDFPLQN IIPQYEDSSSSSDESYSGDVDELKKTRSLGSYSTRGNIKKNQSVKESLTSSSLPGTSF TPTSTKVNLKHENSPFKSTFVNTIDNSKDDLNKPSYEDLDVSKQNLKNSIQQRMIDKL NSSEESFNARKMSKVKLHEKGEIDKPTMLKSSGPISKDKKTKPTPPPKPSHLKPKPPP KPLLLAGRKLSLDK" gene complement(598376..599230) /locus_tag="YNL019C" mRNA complement(598376..599230) /locus_tag="YNL019C" /product="hypothetical protein" CDS complement(598376..599230) /locus_tag="YNL019C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /note="hypothetical protein; expression induced during heat stress; YNL019C has a paralog, YNL033W, that arose from a segmental duplication" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10526.1" /db_xref="SGD:S000004964" /translation="MLYSRESRTTVLFLALVTSLTVLCHSVDVTTVFTTSTITEITTV TAAPQPQNKAETALNTATNIIQTMQFLFNCAPFKWKGPLKITSCALNFIVLLLTAWGY LLKYLQENKLNSDADMEKMVGLGFGEMVGRIFGKGVGKAFTKMDITQKLVYPFEGSNR QKCLLMTVGENSIVPFHDLSTEICFDQYTLDSLSHHNHGSISILDAGSVSALGFADIS SKMPSVSELYTLFGDYTIEVLGGITKLASTLNREDWQGERNGFAVLSRDRPNQTLLSV HMYSSSLL" gene complement(599936..601774) /locus_tag="YNL018C" mRNA complement(599936..601774) /locus_tag="YNL018C" /product="hypothetical protein" CDS complement(599936..601774) /locus_tag="YNL018C" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:mutant phenotype:GO:0043935 sexual sporulation resulting in formation of a cellular spore [PMID:36441813]" /note="Protein required for sporulation; induced during meiosis and sporulation; gene is a member of Centroid, a centromere-linked gene family; YNL018C has a paralog, YNL034W, that arose from a segmental duplication" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10527.1" /db_xref="SGD:S000004963" /translation="MSTSFQEFKAFCNKVGLDFQWLNLQSSKSVPENGSSEGFSAVSD TVQENIRPATEPLNVNQSKDPVSNFFYDVKNAPLWNVYKRNHSGHSSAEACSGVSSRQ APKNIPEAMVKETVLSNHDNVTIINELLPTSSAMHQEESTAMTTSYLLSHSVNDTCNV MFSSSSHNRAMLPSSLVQRNNATTSPTTDSASENNESVPSLTSSVSTSSSVYSSWNPP HSPHISSFPDGNFASLNAEVTCFDFRRTKDSRTKETNESIIPTEIYCPTNSTDHHKHY PSRKSKQDACAPAPCNQNISCSVVSTAEFSQSNHTLTTVVPSYMQQYLDRPQNWFESK MGKYCPLFLRSTKNIDYDSLEFKFERKMIAVQYLLLDEQSEPRRYYNPSNKSIPFWKR PFNFDTMPSYDQLMEEAECRFYSYQYKYEGFQRIEPYSISCPWKNTQREIDLVLDHIH FSLDVGEKKSLNRKGNITLDTLDSKVDPNIQIKPYQIFPSNNLVYEGLPHPAEQSLIL SPDTSLIERAFQALIDICKESIPSSNDCSTRNNNSAPQLTVPEPSKPCRLLLVRESRT ATELKTNKKLWLHSQRRNIEVTVPMHPSERGTKSWLRKWLSTFVHQ" gene 602312..602385 /locus_tag="YNCN0015W" tRNA 602312..602385 /locus_tag="YNCN0015W" /product="tRNA-Ile" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Isoleucine tRNA (tRNA-Ile), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006610" gene 602907..604268 /gene="PUB1" /locus_tag="YNL016W" /gene_synonym="RNP1" mRNA 602907..604268 /gene="PUB1" /locus_tag="YNL016W" /gene_synonym="RNP1" /product="Pub1p" CDS 602907..604268 /gene="PUB1" /locus_tag="YNL016W" /gene_synonym="RNP1" /experiment="EXISTENCE:direct assay:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:10892745]" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:8413212|PMID:15964806|PMID:8413213|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8413212]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8413212|PMID:8413213]" /experiment="EXISTENCE:direct assay:GO:0008266 poly(U) RNA binding [PMID:8413213]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:18981231|PMID:24291094|PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:28467675]" /experiment="EXISTENCE:mutant phenotype:GO:0003729 mRNA binding [PMID:8413213|PMID:8413212]" /experiment="EXISTENCE:mutant phenotype:GO:0006415 translational termination [PMID:28467675]" /experiment="EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:0043488 regulation of mRNA stability [PMID:15964806]" /experiment="EXISTENCE:physical interaction:GO:0006415 translational termination [PMID:28467675]" /note="Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds cell wall mRNAs; required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; implicated in regulation of translation; carries Q/N-rich domain at C- terminus, identified as candidate prion; ribosome-bound Pub1p modulates stop codon decoding during translation termination" /codon_start=1 /product="Pub1p" /protein_id="DAA10528.1" /db_xref="SGD:S000004961" /translation="MSENNEEQHQQQQQQQPVAVETPSAVEAPASADPSSEQSVAVEG NSEQAEDNQGENDPSVVPANAITGGRETSDRVLYVGNLDKAITEDILKQYFQVGGPIA NIKIMIDKNNKNVNYAFVEYHQSHDANIALQTLNGKQIENNIVKINWAFQSQQSSSDD TFNLFVGDLNVNVDDETLRNAFKDFPSYLSGHVMWDMQTGSSRGYGFVSFTSQDDAQN AMDSMQGQDLNGRPLRINWAAKRDNNNNNNYQQRRNYGNNNRGGFRQYNSNNNNNMNM GMNMNMNMNMNNSRGMPPSSMGMPIGAMPLPSQGQPQQSQTIGLPPQVNPQAVDHIIR SAPPRVTTAYIGNIPHFATEADLIPLFQNFGFILDFKHYPEKGCCFIKYDTHEQAAVC IVALANFPFQGRNLRTGWGKERSNFMPQQQQQGGQPLIMNDQQQPVMSEQQQQQQQQQ QQQ" gene 605384..605611 /gene="PBI2" /locus_tag="YNL015W" /gene_synonym="LMA1" mRNA 605384..605611 /gene="PBI2" /locus_tag="YNL015W" /gene_synonym="LMA1" /product="Pbi2p" CDS 605384..605611 /gene="PBI2" /locus_tag="YNL015W" /gene_synonym="LMA1" /experiment="EXISTENCE:direct assay:GO:0004866 endopeptidase inhibitor activity [PMID:2015812]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9159115|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:9159115]" /experiment="EXISTENCE:mutant phenotype:GO:0030162 regulation of proteolysis [PMID:2015812]" /note="Cytosolic inhibitor of vacuolar proteinase B (PRB1); required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="Pbi2p" /protein_id="DAA10529.1" /db_xref="SGD:S000004960" /translation="MTKNFIVTLKKNTPDVEAKKFLDSVHHAGGSIVHEFDIIKGYTI KVPDVLHLNKLKEKHNDVIENVEEDKEVHTN" gene 606319..609453 /gene="HEF3" /locus_tag="YNL014W" /gene_synonym="ZRG7" mRNA 606319..609453 /gene="HEF3" /locus_tag="YNL014W" /gene_synonym="ZRG7" /product="translation elongation factor EF-3" CDS 606319..609453 /gene="HEF3" /locus_tag="YNL014W" /gene_synonym="ZRG7" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:9544245]" /experiment="EXISTENCE:genetic interaction:GO:0003746 translation elongation factor activity [PMID:9544245]" /experiment="EXISTENCE:genetic interaction:GO:0006414 translational elongation [PMID:9544245]" /experiment="EXISTENCE:physical interaction:GO:0022626 cytosolic ribosome [PMID:9544245]" /note="Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication" /codon_start=1 /product="translation elongation factor EF-3" /protein_id="DAA10530.1" /db_xref="SGD:S000004959" /translation="MSDSQQSITVLEELFRKLETATSETREGISSELSSFLNGNIIEH DVPEVFFDEFQKAIQSKQKALNTLGAVAYIANETNLSPSVEPYIVATVPSVCSKAGSK DNDVQLAATKALKAIASAVNPVAVKALLPHLIHSLETSNKWKEKVAVLEVISVLVDAA KEQIALRMPELIPVLSESMWDTKKGVKEAATTTITKATETVDNKDIERFIPKLIECIA NPNEVPETVHLLGATTFVAEVTPATLSIMVPLLSRGLAERETSIKRKAAVIIDNMCKL VEDPQVVAPFLGKLLPGLKNNFATIADPEAREVTLKALKTLRRVGNVGEDDVLPEISH AGDVSTTLGVIKELLEPEKVAPRFTIVVEYIAAIAANLIDERIIDQQTWFTHVTPYMT IFLHEKTAKEILDDFRKRAVDNIPVGPNFQDEEDEGEDLCNCEFSLAYGAKILLNKTQ LRLKRGRRYGLCGPNGAGKSTLMRSIANGQVDGFPTQDECRTVYVEHDIDNTHSDMSV LDFVYSGNVGTKDVITSKLKEFGFSDEMIEMPIASLSGGWKMKLALARAVLKDADILL LDEPTNHLDTVNVEWLVNYLNTCGITSVIVSHDSGFLDKVCQYIIHYEGLKLRKYKGN LSEFVQKCPTAQSYYELGASDLEFQFPTPGYLEGVKTKQKAIVKVSNMTFQYPGTTKP QVSDVTFQCSLSSRIAVIGPNGAGKSTLINVLTGELLPTSGEVYTHENCRIAYIKQHA FAHIESHLDKTPSEYIQWRFQTGEDRETMDRANRQINENDAEAMNKIFKIEGTPRRVA GIHSRRKFKNTYEYECSFLLGENIGMKSERWVPMMSVDNAWLPRGELIESHSKMVAEI DMKEALASGQFRALTRKEIELHCAMLGLDSELVSHSRIRGLSGGQKVKLVLAACTWQR PHLIVLDEPTNYLDRDSLGALSKALKAFEGGVIIITHSAEFTKNLTDEVWAVKDGKMT PSGHNWVAGQGAGPRIEKKEEEGDKFDAMGNKINSGKKKSKLSSAELRKKKKERMKKK KEMGDEYVSSDEDF" rep_origin 609520..609607 /note="ARS1424; Autonomously Replicating Sequence" /db_xref="SGD:S000118391" gene 609686..611665 /gene="SPO1" /locus_tag="YNL012W" mRNA join(609686..609790,609875..611665) /gene="SPO1" /locus_tag="YNL012W" /product="putative carboxylic ester hydrolase" CDS join(609686..609790,609875..611665) /gene="SPO1" /locus_tag="YNL012W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:18756268]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10855497]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:17179081]" /experiment="EXISTENCE:genetic interaction:GO:0032120 ascospore-type prospore membrane formation [PMID:22611022]" /experiment="EXISTENCE:genetic interaction:GO:0070583 spore membrane bending pathway [PMID:18756268]" /experiment="EXISTENCE:mutant phenotype:GO:0007127 meiosis I [PMID:10855497]" /experiment="EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:10855497]" /experiment="EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:26605945|PMID:22611022]" /experiment="EXISTENCE:mutant phenotype:GO:0070583 spore membrane bending pathway [PMID:18756268]" /note="Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B" /codon_start=1 /product="putative carboxylic ester hydrolase" /protein_id="DAA10531.1" /db_xref="SGD:S000004957" /translation="MQKLLFVFSVLLTVVLATAPFQVQCPSSPLIREAKHELCPEETL YLKKKKIKTKNKLIQFLKSLTEAKFSSKFYKRVLKDPPKIGIAISGGGYRSMLVGTGF ISQMNDYGLFEYSDYIAGLSGGSWILMDLVVQNFEVKSLLQEWDLEEDLLLGIPEFDI SEEEIVTNAKKEYNDNDLKMKKRQGGSLITSSSNFYEQIEEIMNSIEEIPEDYMITKR NLNPLARLKKIFFPNNTFTGTDAKIETFKKVLDFYKSLHLKIKPKKMEGFQISFTDYW GKAIVQRLKKNFDDDPNHSFSFSKLVNSSKKFKECSVPIPIFVANCKNGLLSNVIFEF TPFEFGSWENILRLFVKLPYLGSKIVSGKAEKCINNFDDLGFITATSSSIFNNVLIFI WNLASQSSREAMKALNMVMGIFGLGKEEIFSISKDSSRLETDYAVYQPNPFYLYPEKD NVLTNKNHLYLVDGGEDGENIPLRTLVIPERELDVIFVLDSSSDIDNYPNGSKLKRIF EKLDEENVHYQFPNNVKTFTHPIVIGCNATKRTGHDSFLPIIIYHANANHGNASNTST FKITYNQSEVSSMLPTGRGVFSNDYDLYYKNCLGCILTKRTMDRLPRKKKFSPFCLQC FKDYCYS" gene complement(611836..613170) /locus_tag="YNL011C" mRNA complement(611836..613170) /locus_tag="YNL011C" /product="hypothetical protein" CDS complement(611836..613170) /locus_tag="YNL011C" /note="hypothetical protein; YNL011C is not an essential gene" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10532.1" /db_xref="SGD:S000004956" /translation="MNVVVCSGGTATNSLTPCFSNISILKGHELTYILPISDNGGSTS EILRIVGGPAIGDIRSRIVRLLQDEQLVELFGHRLPNDKLLAKKEWNEIVEGSHPIWK NISIEVKEMCRSFIIHMQAELLKKIKHSNPFQFESASIGNFFLTGARLFLGSLDASIE LMMRIGRCSPLVHVIPCINTNHTHHISALLTNGEMITGQSQISHPSKSVPKDNSIAHS AKFIHLLGSYDDHLKILLDDEEEEAEEEYANPIYILPELKNSQLHFDKLDESQNLPAP VHRILYINPYGEEIKPMGNPRAISKVKKADMVVYSIGSLMTSLLPILILGNLAEVILE SNNTKKVLLINNKYDREVFGLDGLHYVQMIIDSMSRAIAGYRQSKGVHSENDDFEWQD FITDIVYLKNGEIEIDETIFEKHSIRCHQIASSDKMESEELEKVLNQIGLKN" gene 613635..614360 /gene="PYP1" /locus_tag="YNL010W" mRNA 613635..614360 /gene="PYP1" /locus_tag="YNL010W" /product="putative phosphoric monoester hydrolase" CDS 613635..614360 /gene="PYP1" /locus_tag="YNL010W" /EC_number="3.1.3.50" /experiment="EXISTENCE:direct assay:GO:0000121 sn-glycerol 1-phosphatase activity [PMID:26071590]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043136 sn-glycerol 3-phosphatase activity [PMID:30240188]" /experiment="EXISTENCE:direct assay:GO:0050286 sorbitol-6-phosphatase activity [PMID:30240188]" /experiment="EXISTENCE:direct assay:GO:0110130 ribitol-5-phosphatase activity [PMID:30240188]" /experiment="EXISTENCE:mutant phenotype:GO:0052646 alditol phosphate metabolic process [PMID:30240188]" /note="Sugar alcohol phosphatase; polyol phosphatase that hydrolyzes sorbitol-6-phosphate, ribitol-5-phosphate, and (D)-glycerol-3-phosphate, maintaining phosphoglucose isomerase (PGI) activity in the presence of PGI-inhibitory sugar alcohols; expression correlated with growth rate; GFP-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant displays increased glycogen accumulation; member of the haloacid dehalogenase (HAD) superfamily" /codon_start=1 /product="putative phosphoric monoester hydrolase" /protein_id="DAA10533.1" /db_xref="SGD:S000004955" /translation="MVKAVIFTDFDGTVTLEDSNDYLTDTLGFGKEKRLKVFEGVLDD TKSFRQGFMEMLESIHTPFPECIKILEKKIRLDPGFKDTFEWAQENDVPVIVVSSGMK PIIKVLLTRLVGQESIHKIDIVSNEVEIDAHDQWKIIYKDESPFGHDKSRSIDAYKKK FESTLKAGEQRPVYFYCGDGVSDLSAAKECDLLFAKRGKDLVTYCKKQNVPFHEFDTF KDILASMKQVLAGEKTVAELMEN" gene 614821..616083 /gene="IDP3" /locus_tag="YNL009W" mRNA 614821..616083 /gene="IDP3" /locus_tag="YNL009W" /product="isocitrate dehydrogenase (NADP(+)) IDP3" CDS 614821..616083 /gene="IDP3" /locus_tag="YNL009W" /EC_number="1.1.1.42" /experiment="EXISTENCE:direct assay:GO:0004450 isocitrate dehydrogenase (NADP+) activity [PMID:9452501]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:15001388]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:9452501]" /experiment="EXISTENCE:mutant phenotype:GO:0006635 fatty acid beta-oxidation [PMID:9452501]" /note="Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication" /codon_start=1 /product="isocitrate dehydrogenase (NADP(+)) IDP3" /protein_id="DAA10534.1" /db_xref="SGD:S000004954" /translation="MSKIKVVHPIVEMDGDEQTRVIWKLIKEKLILPYLDVDLKYYDL SIQERDRTNDQVTKDSSYATLKYGVAVKCATITPDEARMKEFNLKEMWKSPNGTIRNI LGGTVFREPIIIPKIPRLVPHWEKPIIIGRHAFGDQYRATDIKIKKAGKLRLQFSSDD GKENIDLKVYEFPKSGGIAMAMFNTNDSIKGFAKASFELALKRKLPLFFTTKNTILKN YDNQFKQIFDNLFDKEYKEKFQALKITYEHRLIDDMVAQMLKSKGGFIIAMKNYDGDV QSDIVAQGFGSLGLMTSILITPDGKTFESEAAHGTVTRHFRKHQRGEETSTNSIASIF AWTRAIIQRGKLDNTDDVIKFGNLLEKATLDTVQVGGKMTKDLALMLGKTNRSSYVTT EEFIDEVAKRLQNMMLSSNEDKKGMCKL" gene complement(616211..618241) /gene="ASI3" /locus_tag="YNL008C" mRNA complement(616211..618241) /gene="ASI3" /locus_tag="YNL008C" /product="putative ubiquitin-protein ligase ASI3" CDS complement(616211..618241) /gene="ASI3" /locus_tag="YNL008C" /EC_number="2.3.2.27" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:17085444]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0097658 Asi complex [PMID:25236469]" /experiment="EXISTENCE:genetic interaction:GO:0004842 ubiquitin-protein transferase activity [PMID:11454748]" /experiment="EXISTENCE:genetic interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:11454748]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:25236469]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:25253722]" /experiment="EXISTENCE:mutant phenotype:GO:0071230 cellular response to amino acid stimulus [PMID:17085444]" /note="Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and regulators of sterol biosynthesis for ubiquitin-mediated degradation; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids" /codon_start=1 /product="putative ubiquitin-protein ligase ASI3" /protein_id="DAA10535.2" /db_xref="SGD:S000004953" /translation="MSTNILQHVKQLLHNRDVFSFFHNKTGNLNYLDNTTQKPEVFVS PNSTIVSAPTLDSFQALMEKGNFTTLQLAKVGIRMFFSYSVSKYAVLCFSTAIILNRL TVMSSLRSNSTNIRLPLWSKTLLHLVATLSLVKALLQILSQFGLMHELHVSDTDFYAL SVYLFVALSDCIEIFISSTTNVPSLICSDFSIWGLSLNLYIISKMPAGQQHIGDNVEL LGAVFHRLVIHLVELFHIRAYRLCGEVILNAGFFTAFVTRTYLNGLDFINICLIHNYF PGFFYISTILLASIGIFLKALFTSNPFRSLYSRYKNLEKWWRSNNYNGEEEFNEIALS LCLLLTSNDYKIFKKSDNVKSVDEVAAFSNSYVVSGHLNQLQSTPEDLLSRKEMTTDS QLPGFARTYLGLFELVRTIILTYSRLLKNLLWSKNFESSIDKKPRVGKRKKRDLNKYV TEKNYKKFLYKPDVKELNIESDLRSLELLLPEDDSSKDYFPPRKIDESVSDEEFDSDM ESQLIIDEEKELTHLSSNAVDSDDLEEIAWNISMWSILNYEMDVHNKVNGPLTRSQYG KRNPQGVLVDVVIERLLHHTNSRYMYKRLNMKDDDKLEFKFDFAFDSCDEVEEMDLSC LICKVNKRNIVTWPCRCLALCDDCRISLGYKGFATCVSCDSEVKGYSKLNIV" rep_origin 616311..617125 /note="ARS1425; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay" /db_xref="SGD:S000130144" gene complement(618507..619565) /gene="SIS1" /locus_tag="YNL007C" mRNA complement(618507..619565) /gene="SIS1" /locus_tag="YNL007C" /product="type II HSP40 co-chaperone SIS1" CDS complement(618507..619565) /gene="SIS1" /locus_tag="YNL007C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22718905]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:33326013]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:33293525]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:9774392]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:8513501]" /experiment="EXISTENCE:direct assay:GO:0051787 misfolded protein binding [PMID:33293525|PMID:23791384]" /experiment="EXISTENCE:mutant phenotype:GO:0002236 detection of misfolded protein [PMID:33293525]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:8513501]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:14657253]" /experiment="EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:25853343]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:33293525]" /experiment="EXISTENCE:mutant phenotype:GO:0035719 tRNA import into nucleus [PMID:25853343]" /experiment="EXISTENCE:mutant phenotype:GO:0070843 misfolded protein transport [PMID:23791384]" /experiment="EXISTENCE:mutant phenotype:GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system [PMID:23791384]" /experiment="EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:32118579]" /note="Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; shuttles between cytosol and nucleus; mediates delivery of misfolded proteins into the nucleus for degradation; involved in proteasomal degradation of misfolded cytosolic proteins; protein abundance increases in response to DNA replication stress; polyQ aggregates sequester Sis1p and interfere with clearance of misfolded proteins; similar to bacterial DnaJ proteins and mammalian DnaJB1" /codon_start=1 /product="type II HSP40 co-chaperone SIS1" /protein_id="DAA10536.1" /db_xref="SGD:S000004952" /translation="MVKETKLYDLLGVSPSANEQELKKGYRKAALKYHPDKPTGDTEK FKEISEAFEILNDPQKREIYDQYGLEAARSGGPSFGPGGPGGAGGAGGFPGGAGGFSG GHAFSNEDAFNIFSQFFGGSSPFGGADDSGFSFSSYPSGGGAGMGGMPGGMGGMHGGM GGMPGGFRSASSSPTYPEEETVQVNLPVSLEDLFVGKKKSFKIGRKGPHGASEKTQID IQLKPGWKAGTKITYKNQGDYNPQTGRRKTLQFVIQEKSHPNFKRDGDDLIYTLPLSF KESLLGFSKTIQTIDGRTLPLSRVQPVQPSQTSTYPGQGMPTPKNPSQRGNLIVKYKV DYPISLNDAQKRAIDENF" gene 620067..620978 /gene="LST8" /locus_tag="YNL006W" mRNA 620067..620978 /gene="LST8" /locus_tag="YNL006W" /product="TOR complex subunit LST8" CDS 620067..620978 /gene="LST8" /locus_tag="YNL006W" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:12719473]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0010008 endosome membrane [PMID:12719473]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:12719473]" /experiment="EXISTENCE:mutant phenotype:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:12408816]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:12719473]" /experiment="EXISTENCE:mutant phenotype:GO:0031929 TOR signaling [PMID:12719473]" /experiment="EXISTENCE:mutant phenotype:GO:0031930 mitochondria-nucleus signaling pathway [PMID:11742997]" /experiment="EXISTENCE:mutant phenotype:GO:0043539 protein serine/threonine kinase activator activity [PMID:16002396]" /experiment="EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:12408816]" /experiment="EXISTENCE:physical interaction:GO:0031931 TORC1 complex [PMID:12408816]" /experiment="EXISTENCE:physical interaction:GO:0031932 TORC2 complex [PMID:12408816]" /note="Subunit of TORC1 and TORC2 involved in TOR signaling; TORC1 regulates nutrient responsive growth and TORC2 regulates plasma membrane (PM) homeostasis and cell-cycle dependent actin cytoskeleton polarization; negative regulator of Rtg1p/3p and Gln3p transcription factors and amino acid biosynthesis; binds to both Tor1p and Tor2p, regulating the integrity and kinase activity of TORC2; PM retention is dependent on Avo3p; WD-repeat protein" /codon_start=1 /product="TOR complex subunit LST8" /protein_id="DAA10537.1" /db_xref="SGD:S000004951" /translation="MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDK KLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW DVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDT SLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD VKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRL WDLSTREIVRQYGGHHKGAVCVALNDV" gene complement(621313..622428) /gene="MRP7" /locus_tag="YNL005C" /gene_synonym="bL27m" mRNA complement(621313..622428) /gene="MRP7" /locus_tag="YNL005C" /gene_synonym="bL27m" /product="mitochondrial 54S ribosomal protein YmL2" CDS complement(621313..622428) /gene="MRP7" /locus_tag="YNL005C" /gene_synonym="bL27m" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:28931599]" /note="Mitochondrial ribosomal protein of the large subunit; involved together with Mrpl35p in assembly of cytochrome c oxidase" /codon_start=1 /product="mitochondrial 54S ribosomal protein bL27m MRP7" /protein_id="DAA10538.1" /db_xref="SGD:S000004950" /translation="MWNPILLDTSSFSFQKHVSGVFLQVRNATKRAAGSRTSMKDSAG RRLGPKKYEGQDVSTGEIIMRQRGTKFYPGENVGIGKDHSIFALEPGVVRYYLDPFHP KRKFIGVALRRDLKLPSPHFEPTVRRFGRFELTNKRAAYKEENSISRKDYLAKPNILK QLEVRESKRKELQDKLSKVLRDELKLDIKDIELATSYLIRVRASLKNGYPIEDARFNS RYYLKEEERLKARRESWTNEKLSESLSKIDECSDLLNSSTSFNNKLELHQYISEQEKQ ALKAKLLEDLEKSQHLETKKDKNYIKALFKDACNFLTLSEEVHLRRKYLKSVFPETDS TVETKSGKKSIVSRRFDYTKNKVEVIARSRRAFLSKL" gene 622915..624621 /gene="HRB1" /locus_tag="YNL004W" /gene_synonym="TOM34" mRNA join(622915..622944,623287..624621) /gene="HRB1" /locus_tag="YNL004W" /gene_synonym="TOM34" /product="mRNA-binding protein" CDS join(622915..622944,623287..624621) /gene="HRB1" /locus_tag="YNL004W" /gene_synonym="TOM34" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:14769921]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:14676199]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:14769921|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9499403]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9499403]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:24452287]" /note="Poly(A+) RNA-binding guard protein; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication" /codon_start=1 /product="mRNA-binding protein" /protein_id="DAA10539.1" /db_xref="SGD:S000004949" /translation="MSDQERGSENNNRSRSRSRSPVRRRMSDDHGYERDNHLSRRSGN YNGRRKFADTYRGSRDRGEYRGGRERSDYRERERFNNRDNPRSRDRYDDRRRGRDVTG RYGNRRDDYPRSFRSRHNTRDDSRRGGFGSSGARGDYGPLLARELDSTYEEKVNRNYS NSIFVGNLTYDSTPEDLTEFFSQIGKVVRADIITSRGHHRGMGTVEFTNSDDVDRAIR QYDGAFFMDRKIFVRQDNPPPSNNIKERKALDRGELRHNRKTHEVIVKNLPASVNWQA LKDIFKECGNVAHADVELDGDGVSTGSGTVSFYDIKDLHRAIEKYNGYSIEGNVLDVK SKESVHNHSDGDDVDIPMDDSPVNEEARKFTENVVGGGERNRLIYCSNLPFSTAKSDL YDLFETIGKVNNAELRYDSKGAPTGIAVVEYDNVDDADVCIERLNNYNYGGCDLDISY AKRL" gene complement(624975..625829) /gene="PET8" /locus_tag="YNL003C" /gene_synonym="SAM5" mRNA complement(624975..625829) /gene="PET8" /locus_tag="YNL003C" /gene_synonym="SAM5" /product="Pet8p" CDS complement(624975..625829) /gene="PET8" /locus_tag="YNL003C" /gene_synonym="SAM5" /experiment="EXISTENCE:direct assay:GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity [PMID:14609944]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14609944|PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0015805 S-adenosyl-L-methionine transport [PMID:14609944]" /experiment="EXISTENCE:genetic interaction:GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity [PMID:14609944]" /experiment="EXISTENCE:genetic interaction:GO:0015805 S-adenosyl-L-methionine transport [PMID:14609944]" /experiment="EXISTENCE:mutant phenotype:GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity [PMID:14609944]" /experiment="EXISTENCE:mutant phenotype:GO:0015805 S-adenosyl-L-methionine transport [PMID:14609944]" /note="S-adenosylmethionine transporter of the mitochondrial inner membrane; member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth" /codon_start=1 /product="Pet8p" /protein_id="DAA10540.1" /db_xref="SGD:S000004948" /translation="MNTFFLSLLSGAAAGTSTDLVFFPIDTIKTRLQAKGGFFANGGY KGIYRGLGSAVVASAPGASLFFISYDYMKVKSRPYISKLYSQGSEQLIDTTTHMLSSS IGEICACLVRVPAEVVKQRTQVHSTNSSWQTLQSILRNDNKEGLRKNLYRGWSTTIMR EIPFTCIQFPLYEYLKKTWAKANGQSQVEPWKGAICGSIAGGIAAATTTPLDFLKTRL MLNKTTASLGSVIIRIYREEGPAVFFSGVGPRTMWISAGGAIFLGMYETVHSLLSKSF PTAGEMRA" gene complement(626174..627142) /gene="RLP7" /locus_tag="YNL002C" /gene_synonym="RPL7" mRNA complement(626174..627142) /gene="RLP7" /locus_tag="YNL002C" /gene_synonym="RPL7" /product="Rlp7p" CDS complement(626174..627142) /gene="RLP7" /locus_tag="YNL002C" /gene_synonym="RPL7" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11087857]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17443350|PMID:11583614]" /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:24129494]" /experiment="EXISTENCE:direct assay:GO:0042273 ribosomal large subunit biogenesis [PMID:23945946]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11087857]" /experiment="EXISTENCE:mutant phenotype:GO:0000465 exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11087857]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11087857]" /note="Nucleolar protein similar to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs; binds junction of ITS2 and ITS2-proximal stem between the 3' end of 5.8S rRNA and the 5' end of 25S rRNA" /codon_start=1 /product="Rlp7p" /protein_id="DAA10541.1" /db_xref="SGD:S000004947" /translation="MSSTQDSKAQTLNSNPEILLRKRRNADRTRIERQELAKKKREEQ IKKKRSNKNKFVRAESIVAKTLATSREKERIKRVSILEDKKAKNETQHIASGKDFILK ITEKANGAEENSVDLEETEEEEDDGLIREKTTYDGKPALLFIVRVRGPLAVNIPNKAF KILSLLRLVETNTGVFVKLTKNVYPLLKVIAPYVVIGKPSLSSIRSLIQKRGRIIYKG ENEAEPHEIVLNDNNIVEEQLGDHGIICVEDIIHEIATMGESFSVCNFFLQPFKLNRE VSGFGSLNRLRKIKQREAESRTRQFSNAATAPVIEVDIDSLLAKLN" gene 627456..628616 /gene="DOM34" /locus_tag="YNL001W" mRNA 627456..628616 /gene="DOM34" /locus_tag="YNL001W" /product="ribosome dissociation factor DOM34" CDS 627456..628616 /gene="DOM34" /locus_tag="YNL001W" /experiment="EXISTENCE:direct assay:GO:0004521 RNA endonuclease activity [PMID:17889667]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032790 ribosome disassembly [PMID:20947765|PMID:24424461]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:21623367]" /experiment="EXISTENCE:direct assay:GO:1990533 Dom34-Hbs1 complex [PMID:21623367]" /experiment="EXISTENCE:genetic interaction:GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay [PMID:16554824]" /experiment="EXISTENCE:mutant phenotype:GO:0032790 ribosome disassembly [PMID:24424461|PMID:22770215]" /experiment="EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:24424461]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:19481524]" /experiment="EXISTENCE:mutant phenotype:GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay [PMID:19420139]" /note="Protein that facilitates ribosomal subunit dissociation; Dom34-Hbs1 complex and Rli1p have roles in dissociating inactive ribosomes to facilitate translation restart, particularly ribosomes stalled in 3' UTRs; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication" /codon_start=1 /product="ribosome dissociation factor DOM34" /protein_id="DAA10542.1" /db_xref="SGD:S000004946" /translation="MKVISLKKDSFNKGGAVITLLPEDKEDLFTVYQIVDKDDELIFK KKFTSKLDEAGKKKSTDLVKLKIKVISEDFDMKDEYLKYKGVTVTDESGASNVDIPVG KYLSFTLDYVYPFTIIKQNFNKFMQKLLNEACNIEYKSDTAAVVLQEGIAHVCLVTSS STILKQKIEYSMPKKKRTTDVLKFDEKTEKFYKAIYSAMKKDLNFDKLKTIILCSPGF YAKILMDKIFQYAEEEHNKKILDNKGMFFIAHCSTGYLQGINEVLKNPLYASKLQDTK YSKEIMVMDEFLLHLNKDDDKAWYGEKEVVKAAEYGAISYLLLTDKVLHSDNIAQREE YLKLMDSVESNGGKALVLSTLHSLGEELDQLTGIACILKYPLPDLDEDDGEE" centromere 628758..628875 /note="CEN14; Chromosome XIV centromere" /db_xref="SGD:S000006475" centromere 628758..628767 /note="CEN14_CDEI of CEN14" centromere 628768..628850 /note="CEN14_CDEII of CEN14" centromere 628851..628875 /note="CEN14_CDEIII of CEN14" gene complement(629622..631061) /gene="CIT1" /locus_tag="YNR001C" /gene_synonym="LYS6" mRNA complement(629622..631061) /gene="CIT1" /locus_tag="YNR001C" /gene_synonym="LYS6" /product="citrate (Si)-synthase CIT1" CDS complement(629622..631061) /gene="CIT1" /locus_tag="YNR001C" /gene_synonym="LYS6" /EC_number="2.3.3.1" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:24769239|PMID:14576278|PMID:11914276|P MID:16823961]" /experiment="EXISTENCE:direct assay:GO:0036440 citrate synthase activity [PMID:17570335]" /experiment="EXISTENCE:direct assay:GO:0046356 acetyl-CoA catabolic process [PMID:17570335]" /experiment="EXISTENCE:genetic interaction:GO:0006101 citrate metabolic process [PMID:12913175]" /experiment="EXISTENCE:mutant phenotype:GO:0036440 citrate synthase activity [PMID:17570335]" /experiment="EXISTENCE:mutant phenotype:GO:0046356 acetyl-CoA catabolic process [PMID:17570335]" /experiment="EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]" /note="Mitochondrial citrate synthase; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate, which is the first and rate-limiting step of the TCA cycle; transcription subject to glucose repression; CIT1 has a paralog, CIT2, that arose from the whole genome duplication" /codon_start=1 /product="citrate (Si)-synthase CIT1" /protein_id="DAA10543.1" /db_xref="SGD:S000005284" /translation="MSAILSTTSKSFLSRGSTRQCQNMQKALFALLNARHYSSASEQT LKERFAEIIPAKAEEIKKFKKEHGKTVIGEVLLEQAYGGMRGIKGLVWEGSVLDPEEG IRFRGRTIPEIQRELPKAEGSTEPLPEALFWLLLTGEIPTDAQVKALSADLAARSEIP EHVIQLLDSLPKDLHPMAQFSIAVTALESESKFAKAYAQGVSKKEYWSYTFEDSLDLL GKLPVIASKIYRNVFKDGKITSTDPNADYGKNLAQLLGYENKDFIDLMRLYLTIHSDH EGGNVSAHTTHLVGSALSSPYLSLAAGLNGLAGPLHGRANQEVLEWLFKLREEVKGDY SKETIEKYLWDTLNAGRVVPGYGHAVLRKTDPRYTAQREFALKHFPDYELFKLVSTIY EVAPGVLTKHGKTKNPWPNVDSHSGVLLQYYGLTEASFYTVLFGVARAIGVLPQLIID RAVGAPIERPKSFSTEKYKELVKKIESKN" gene complement(631846..631917) /gene="SUF10" /locus_tag="YNCN0016C" tRNA complement(631846..631917) /gene="SUF10" /locus_tag="YNCN0016C" /product="tRNA-Pro" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Proline tRNA (tRNA-Pro), predicted by tRNAscan-SE analysis; can mutate to suppress +1 frameshift mutations in proline codons" /db_xref="SGD:S000006679" repeat_region complement(631998..632114) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007143" repeat_region complement(632119..632489) /note="Ty4 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007146" gene 632599..632672 /locus_tag="YNCN0017W" tRNA 632599..632672 /locus_tag="YNCN0017W" /product="tRNA-Asn" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Asparagine tRNA (tRNA-Asn), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006674" gene complement(633008..633856) /gene="ATO2" /locus_tag="YNR002C" /gene_synonym="FUN34" mRNA complement(633008..633856) /gene="ATO2" /locus_tag="YNR002C" /gene_synonym="FUN34" /product="putative ammonium permease ATO2" CDS complement(633008..633856) /gene="ATO2" /locus_tag="YNR002C" /gene_synonym="FUN34" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17395151]" /experiment="EXISTENCE:mutant phenotype:GO:0008519 ammonium channel activity [PMID:12429834]" /experiment="EXISTENCE:mutant phenotype:GO:0019740 nitrogen utilization [PMID:12429834]" /experiment="EXISTENCE:mutant phenotype:GO:0072488 ammonium transmembrane transport [PMID:12429834]" /note="Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication" /codon_start=1 /product="putative ammonium permease ATO2" /protein_id="DAA10544.1" /db_xref="SGD:S000005285" /translation="MSDREQSSGNTAFENPKALDSSEGEFISENNDQSRHSQESICKI YTAGKNNEYIYIGRQKFLRDDLFEAFGGTLNPGLAPAPVHKFANPAPLGLSGFALTTF VLSMFNARAQGITIPNVVVGCAMFYGGLVQLIAGIWEIALENTFGGTALCSFGGFWLS FGAIYIPWFGILDAYKDKESDLGNALGFYLLGWALFTFGLSVCTMKSTIMFFALFFLL AVTFLLLSIANFTGEVGVTRAGGVLGVIVAFIAWYNAYAGIATRQNSYIMVHPFALPS NDKVFF" gene complement(634344..635297) /gene="RPC34" /locus_tag="YNR003C" mRNA complement(634344..635297) /gene="RPC34" /locus_tag="YNR003C" /product="DNA-directed RNA polymerase III subunit C34" CDS complement(634344..635297) /gene="RPC34" /locus_tag="YNR003C" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:3905793|PMID:10611227]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:1400451]" /experiment="EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]" /note="RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex" /codon_start=1 /product="DNA-directed RNA polymerase III subunit C34" /protein_id="DAA10545.1" /db_xref="SGD:S000005286" /translation="MSGMIENGLQLSDNAKTLHSQMMSKGIGALFTQQELQKQMGIGS LTDLMSIVQELLDKNLIKLVKQNDELKFQGVLESEAQKKATMSAEEALVYSYIEASGR EGIWSKTIKARTNLHQHVVLKCLKSLESQRYVKSVKSVKFPTRKIYMLYSLQPSVDIT GGPWFTDGELDIEFINSLLTIVWRFISENTFPNGFKNFENGPKKNVFYAPNVKNYSTT QEILEFITAAQVANVELTPSNIRSLCEVLVYDDKLEKVTHDCYRVTLESILQMNQGEG EPEAGNKALEDEEEFSIFNYFKMFPASKHDKEVVYFDEWTI" rep_origin 635664..635904 /note="ARS1426; Autonomously Replicating Sequence" /db_xref="SGD:S000118392" gene 635943..636383 /gene="SWM2" /locus_tag="YNR004W" mRNA 635943..636383 /gene="SWM2" /locus_tag="YNR004W" /product="Swm2p" CDS 635943..636383 /gene="SWM2" /locus_tag="YNR004W" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:27348091]" /experiment="EXISTENCE:mutant phenotype:GO:0036261 7-methylguanosine cap hypermethylation [PMID:20621096]" /note="Protein with a role in snRNA and snoRNA cap trimethylation; interacts with Tgs1p and shows similar phenotypes; required for trimethylation of the caps of spliceosomal snRNAs and the U3 snoRNA, and for efficient 3' end processing of U3 snoRNA; may act as a specificity factor for Tgs1p" /codon_start=1 /product="Swm2p" /protein_id="DAA10546.1" /db_xref="SGD:S000005287" /translation="MIDLYNYSNLEGLLDGLTDLNRIPKEYSAVLEPYFQNIARNAHL KSRALKICRSNFHKWNEEGAKTVNPEIIRRCLNLWYVLKGKEYKKLKDPPPADNIIKD EIDVSYVKNLNVVRLEFDEFGKLISNPLENLILEEVEVNDFIQE" gene 636986..638854 /gene="VPS27" /locus_tag="YNR006W" /gene_synonym="DID7" /gene_synonym="GRD11" /gene_synonym="SSV17" /gene_synonym="VPL23" /gene_synonym="VPT27" mRNA 636986..638854 /gene="VPS27" /locus_tag="YNR006W" /gene_synonym="DID7" /gene_synonym="GRD11" /gene_synonym="SSV17" /gene_synonym="VPL23" /gene_synonym="VPT27" /product="ESCRT-0 subunit protein VPS27" CDS 636986..638854 /gene="VPS27" /locus_tag="YNR006W" /gene_synonym="DID7" /gene_synonym="GRD11" /gene_synonym="SSV17" /gene_synonym="VPL23" /gene_synonym="VPT27" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:12055639]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:31740006]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:9702203]" /experiment="EXISTENCE:direct assay:GO:0036435 K48-linked polyubiquitin modification-dependent protein binding [PMID:28525741]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:12055639|PMID:20150893]" /experiment="EXISTENCE:direct assay:GO:0070530 K63-linked polyubiquitin modification-dependent protein binding [PMID:28525741]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12055639]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:32726584]" /experiment="EXISTENCE:mutant phenotype:GO:0016237 microautophagy [PMID:31740006]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:8649377]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:12055639]" /experiment="EXISTENCE:mutant phenotype:GO:0140504 microlipophagy [PMID:32726584]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /experiment="EXISTENCE:physical interaction:GO:0006623 protein targeting to vacuole [PMID:12055639]" /experiment="EXISTENCE:physical interaction:GO:0033565 ESCRT-0 complex [PMID:12055639]" /note="Ubiquitin binding protein involved in endosomal protein sorting; K48-, K63-Ub chain binding protein that preferentially binds K63-linked chains in vitro; subunit of the ESCRT-0 complex that binds to ubiquitin via two ubiquitin-interacting motifs (UIMs) and is involved in sorting cargo into multivesicular bodies; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation" /codon_start=1 /product="ESCRT-0 subunit protein VPS27" /protein_id="DAA10547.1" /db_xref="SGD:S000005289" /translation="MSVSTPSELDALIEQATSESIPNGDLDLPIALEISDVLRSRRVN PKDSMRCIKKRILNTADNPNTQLSSWKLTNICVKNGGTPFIKEICSREFMDTMEHVIL REDSNEELSELVKTILYELYVAFKNDSQLNYVAKVYDKLISRGIKFPEKLTLSNSPTA MFDSKTPADWIDSDACMICSKKFSLLNRKHHCRSCGGVFCQEHSSNSIPLPDLGIYEP VRVCDSCFEDYDLKRHDDSKKSKKHRHKRKKDRDYSTPEDEEELIRKAIELSLKESRN SASSEPIVPVVESKNEVKRQEIEEEEDPDLKAAIQESLREAEEAKLRSERQKASRQMQ PQQPSPQPQPIHSVDLSDEEKDSIYMFASLVEKMKSRPLNEILEDSKLQNLAQRVFAS KARLNYALNDKAQKYNTLIEMNGKISEIMNIYDRLLEQQLQSINLSQQYTLPQVPSDP YNYLTENVQNPAESYQTPPLQQLSSHQYKPQQDVSRQQSVKANSSPTTNIDHLKTIDV TPHAQQKPQSHVELAPSDPPYPKEEAEDEGTQAVQDEESSTQESRERPYPVETENGET SINKRPQGITRYDFPTVPARKFVQPESTVPLPASSSEIPIKEERPPSPQEELLIEL" gene complement(639182..640114) /gene="ATG3" /locus_tag="YNR007C" /gene_synonym="APG3" /gene_synonym="AUT1" mRNA complement(639182..640114) /gene="ATG3" /locus_tag="YNR007C" /gene_synonym="APG3" /gene_synonym="AUT1" /product="Atg3p" CDS complement(639182..640114) /gene="ATG3" /locus_tag="YNR007C" /gene_synonym="APG3" /gene_synonym="AUT1" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:25680528|PMID:25645919]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006501 C-terminal protein lipidation [PMID:15277523]" /experiment="EXISTENCE:direct assay:GO:0061908 phagophore [PMID:25680528|PMID:25645919]" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:25680528]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0006501 C-terminal protein lipidation [PMID:15277523|PMID:11100732]" /experiment="EXISTENCE:mutant phenotype:GO:0019776 Atg8-family ligase activity [PMID:11100732]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:9023185]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /experiment="EXISTENCE:mutant phenotype:GO:0061908 phagophore [PMID:25680528]" /note="E2-like enzyme; involved in autophagy and cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p regulated by acetylation by NuA4 histone acetyltransferase Esa1p while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p; Atg12p-Atg5p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site" /codon_start=1 /product="Atg3p" /protein_id="DAA10548.1" /db_xref="SGD:S000005290" /translation="MIRSTLSSWREYLTPITHKSTFLTTGQITPEEFVQAGDYLCHMF PTWKWNEESSDISYRDFLPKNKQFLIIRKVPCDKRAEQCVEVEGPDVIMKGFAEDGDE DDVLEYIGSETEHVQSTPAGGTKDSSIDDIDELIQDMEIKEEDENDDTEEFNAKGGLA KDMAQERYYDLYIAYSTSYRVPKMYIVGFNSNGSPLSPEQMFEDISADYRTKTATIEK LPFYKNSVLSVSIHPCKHANVMKILLDKVRVVRQRRRKELQEEQELDGVGDWEDLQDD IDDSLRVDQYLIVFLKFITSVTPSIQHDYTMEGW" gene 640396..642381 /gene="LRO1" /locus_tag="YNR008W" mRNA 640396..642381 /gene="LRO1" /locus_tag="YNR008W" /product="phospholipid:diacylglycerol acyltransferase" CDS 640396..642381 /gene="LRO1" /locus_tag="YNR008W" /EC_number="2.3.1.158" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:31422915]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:22454508]" /experiment="EXISTENCE:direct assay:GO:0006672 ceramide metabolic process [PMID:22738231]" /experiment="EXISTENCE:direct assay:GO:0019432 triglyceride biosynthetic process [PMID:10747858]" /experiment="EXISTENCE:direct assay:GO:0019915 lipid storage [PMID:10747858]" /experiment="EXISTENCE:direct assay:GO:0046027 phospholipid:diacylglycerol acyltransferase activity [PMID:10747858]" /experiment="EXISTENCE:direct assay:GO:0055091 phospholipid homeostasis [PMID:31422915]" /experiment="EXISTENCE:direct assay:GO:0097038 perinuclear endoplasmic reticulum [PMID:22454508]" /experiment="EXISTENCE:mutant phenotype:GO:0006672 ceramide metabolic process [PMID:22738231]" /experiment="EXISTENCE:mutant phenotype:GO:0019432 triglyceride biosynthetic process [PMID:10747858]" /experiment="EXISTENCE:mutant phenotype:GO:0019915 lipid storage [PMID:10747858]" /note="Acyltransferase that converts diacylglycerol to triacylglycerol (TGA); one of several acyltransferases that contribute to TGA synthesis; relocates from ER to nuclear membrane in response cell cycle and starvation signals; Lro1p and Dga1p can O-acylate ceramides; putative homolog of human lecithin cholesterol acyltransferase" /codon_start=1 /product="phospholipid:diacylglycerol acyltransferase" /protein_id="DAA10549.1" /db_xref="SGD:S000005291" /translation="MGTLFRRNVQNQKSDSDENNKGGSVHNKRESRNHIHHQQGLGHK RRRGISGSAKRNERGKDFDRKRDGNGRKRWRDSRRLIFILGAFLGVLLPFSFGAYHVH NSDSDLFDNFVNFDSLKVYLDDWKDVLPQGISSFIDDIQAGNYSTSSLDDLSENFAVG KQLLRDYNIEAKHPVVMVPGVISTGIESWGVIGDDECDSSAHFRKRLWGSFYMLRTMV MDKVCWLKHVMLDPETGLDPPNFTLRAAQGFESTDYFIAGYWIWNKVFQNLGVIGYEP NKMTSAAYDWRLAYLDLERRDRYFTKLKEQIELFHQLSGEKVCLIGHSMGSQIIFYFM KWVEAEGPLYGNGGRGWVNEHIDSFINAAGTLLGAPKAVPALISGEMKDTIQLNTLAM YGLEKFFSRIERVKMLQTWGGIPSMLPKGEEVIWGDMKSSSEDALNNNTDTYGNFIRF ERNTSDAFNKNLTMKDAINMTLSISPEWLQRRVHEQYSFGYSKNEEELRKNELHHKHW SNPMEVPLPEAPHMKIYCIYGVNNPTERAYVYKEEDDSSALNLTIDYESKQPVFLTEG DGTVPLVAHSMCHKWAQGASPYNPAGINVTIVEMKHQPDRFDIRGGAKSAEHVDILGS AELNDYILKIASGNGDLVEPRQLSNLSQWVSQMPFPM" gene 642690..643439 /gene="NRM1" /locus_tag="YNR009W" mRNA 642690..643439 /gene="NRM1" /locus_tag="YNR009W" /product="Nrm1p" CDS 642690..643439 /gene="NRM1" /locus_tag="YNR009W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030907 MBF transcription complex [PMID:16916637]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:16916637]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16916637]" /experiment="EXISTENCE:physical interaction:GO:0140297 DNA-binding transcription factor binding [PMID:16916637]" /note="Transcriptional co-repressor of MBF-regulated gene expression; Nrm1p associates stably with promoters via MCB binding factor (MBF) to repress transcription upon exit from G1 phase" /codon_start=1 /product="Nrm1p" /protein_id="DAA10550.1" /db_xref="SGD:S000005292" /translation="MSIMKQRLPLGEFSSSKINKLAIANIADASEPRNHGENNVGTVC LPSIKSLMVSPEVYENTKSLPVPLMRSSGGGMACASKSSCQDGISTKTTSRDYSELSK KLQIRLQFAYYKYKTKQTDKNFTDLKSKHSITRPSKVATHSKSEPLTRRRKLVLSQGH YKTPARSKIKTPSSICSHDNTSSFTSFRGVSESSSTTADMNVADTTTPIRNNINTKHS NSHNRTLYQRQETPTSIKAAKSLIHLFTSNQ" gene 643744..644193 /gene="CSE2" /locus_tag="YNR010W" /gene_synonym="MED9" mRNA 643744..644193 /gene="CSE2" /locus_tag="YNR010W" /gene_synonym="MED9" /product="Cse2p" CDS 643744..644193 /gene="CSE2" /locus_tag="YNR010W" /gene_synonym="MED9" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:19077037]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:19077037]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9812975]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11470794]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:19077037]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9891034]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Middle domain of mediator; required for regulation of RNA polymerase II activity; relocalizes to the cytosol in response to hypoxia" /codon_start=1 /product="Cse2p" /protein_id="DAA10551.1" /db_xref="SGD:S000005293" /translation="MNLQNNVLNQIHQILLPTNPTLDKPNAEATKEEFSSAENRDEKD YLTNQQPKNLSTPSTSSNGEFIPHIFYSLHQIRKDPNNLSNQLETLTGSIRHRLKLCK SLISENEDTKDLLSKSPSEWQDIIHQREQELQIKRDVLDDLYRKLQR" gene complement(644320..646950) /gene="PRP2" /locus_tag="YNR011C" /gene_synonym="RNA2" mRNA complement(644320..646950) /gene="PRP2" /locus_tag="YNR011C" /gene_synonym="RNA2" /product="DEAH-box RNA-dependent ATPase PRP2" CDS complement(644320..646950) /gene="PRP2" /locus_tag="YNR011C" /gene_synonym="RNA2" /EC_number="3.6.4.13" /experiment="EXISTENCE:direct assay:GO:0000349 generation of catalytic spliceosome for first transesterification step [PMID:8943336]" /experiment="EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:1534753]" /experiment="EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:2251118]" /experiment="EXISTENCE:mutant phenotype:GO:0034247 snoRNA splicing [PMID:24442613]" /note="RNA-dependent DExH-box ATPase/helicase; required for activation of spliceosome before first transesterification step in RNA splicing; implicated in rearranging and proofreading snRNA structure in catalytic activation of spliceosome; ortholog of human protein DHX16" /codon_start=1 /product="DEAH-box RNA-dependent ATPase PRP2" /protein_id="DAA10552.1" /db_xref="SGD:S000005294" /translation="MSSITSETGKRRVKRTYEVTRQNDNAVRIEPSSLGEEEDKEAKD KNSALQLKRSRYDPNKVFSNTNQGPEKNNLKGEQLGSQKKSSKYDEKITSNNELTTKK GLLGDSENETKYASSNSKFNVEVTHKIKNAKEIDKINRQRMWEEQQLRNAMAGQSDHP DDITLEGSDKYDYVFDTDAMIDYTNEEDDLLPEEKLQYEARLAQALETEEKRILTIQE ARKLLPVHQYKDELLQEIKKNQVLIIMGETGSGKTTQLPQYLVEDGFTDQGKLQIAIT QPRRVAATSVAARVADEMNVVLGKEVGYQIRFEDKTTPNKTVLKYMTDGMLLREFLTD SKLSKYSCIMIDEAHERTLATDILIGLLKDILPQRPTLKLLISSATMNAKKFSEFFDN CPIFNVPGRRYPVDIHYTLQPEANYIHAAITTIFQIHTTQSLPGDILVFLTGQEEIER TKTKLEEIMSKLGSRTKQMIITPIYANLPQEQQLKIFQPTPENCRKVVLATNIAETSL TIDGIRYVIDPGFVKENSYVPSTGMTQLLTVPCSRASVDQRAGRAGRVGPGKCFRIFT KWSYLHELELMPKPEITRTNLSNTVLLLLSLGVTDLIKFPLMDKPSIPTLRKSLENLY ILGALNSKGTITRLGKMMCEFPCEPEFAKVLYTAATHEQCQGVLEECLTIVSMLHETP SLFIGQKRDAAASVLSEVESDHILYLEIFNQWRNSKFSRSWCQDHKIQFKTMLRVRNI RNQLFRCSEKVGLVEKNDQARMKIGNIAGYINARITRCFISGFPMNIVQLGPTGYQTM GRSSGGLNVSVHPTSILFVNHKEKAQRPSKYVLYQQLMLTSKEFIRDCLVIPKEEWLI DMVPQIFKDLIDDKTNRGRR" gene 647432..648937 /gene="URK1" /locus_tag="YNR012W" mRNA 647432..648937 /gene="URK1" /locus_tag="YNR012W" /product="uridine kinase URK1" CDS 647432..648937 /gene="URK1" /locus_tag="YNR012W" /EC_number="2.7.1.48" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004849 uridine kinase activity [PMID:10501935]" /experiment="EXISTENCE:mutant phenotype:GO:0008655 pyrimidine-containing compound salvage [PMID:11872485]" /note="Uridine/cytidine kinase; component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP" /codon_start=1 /product="uridine kinase URK1" /protein_id="DAA10553.1" /db_xref="SGD:S000005295" /translation="MSHRIAPSKERSSSFISILDDETRDTLKANAVMDGEVDVKKTKG KSSRYIPPWTTPYIIGIGGASGSGKTSVAAKIVSSINVPWTVLISLDNFYNPLGPEDR ARAFKNEYDFDEPNAINLDLAYKCILNLKEGKRTNIPVYSFVHHNRVPDKNIVIYGAS VVVIEGIYALYDRRLLDLMDLKIYVDADLDVCLARRLSRDIVSRGRDLDGCIQQWEKF VKPNAVKFVKPTMKNADAIIPSMSDNATAVNLIINHIKSKLELKSNEHLRELIKLGSS PSQDVLNRNIIHELPPTNQVLSLHTMLLNKNLNCADFVFYFDRLATILLSWALDDIPV AHTNIITPGEHTMENVIACQFDQVTAVNIIRSGDCFMKSLRKTIPNITIGKLLIQSDS QTGEPQLHCEFLPPNIEKFGKVFLMEGQIISGAAMIMAIQVLLDHGIDLEKISVVVYL ATEVGIRRILNAFDNKVNIFAGMIISREKLQNHQYKWALTRFFDSKYFGCD" gene complement(649028..651712) /gene="PHO91" /locus_tag="YNR013C" mRNA complement(649028..651712) /gene="PHO91" /locus_tag="YNR013C" /product="Pho91p" CDS complement(649028..651712) /gene="PHO91" /locus_tag="YNR013C" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:17804816]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]" /experiment="EXISTENCE:genetic interaction:GO:0005315 phosphate transmembrane transporter activity [PMID:11779791]" /experiment="EXISTENCE:genetic interaction:GO:0006817 phosphate ion transport [PMID:11779791]" /experiment="EXISTENCE:genetic interaction:GO:0015169 glycerol-3-phosphate transmembrane transporter activity [PMID:20133652]" /experiment="EXISTENCE:genetic interaction:GO:0015794 glycerol-3-phosphate transmembrane transport [PMID:20133652]" /experiment="EXISTENCE:genetic interaction:GO:2000185 regulation of phosphate transmembrane transport [PMID:12821119]" /experiment="EXISTENCE:mutant phenotype:GO:0005315 phosphate transmembrane transporter activity [PMID:12581367]" /experiment="EXISTENCE:mutant phenotype:GO:0006797 polyphosphate metabolic process [PMID:17804816]" /experiment="EXISTENCE:mutant phenotype:GO:0015169 glycerol-3-phosphate transmembrane transporter activity [PMID:20133652]" /experiment="EXISTENCE:mutant phenotype:GO:0015794 glycerol-3-phosphate transmembrane transport [PMID:20133652]" /note="Low-affinity vacuolar phosphate transporter; exports phosphate from vacuolar lumen to cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of PHO pathway; localizes to sites of contact between vacuole and mitochondria (vCLAMPs); targeted to vacuole via AP-3 pathway; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth" /codon_start=1 /product="Pho91p" /protein_id="DAA10554.1" /db_xref="SGD:S000005296" /translation="MKFSHSLQFNSVPEWSTKYLAYSQLKKLIYSLQKDKLYSNNKHH VVEPHDANDENLPLLADASPDDQFYISKFVAALNQELKKIDKFYISQETGLIANYNEL KDDVMELENTNKATQLFNQQQQHQLQSVARNRKSKSQQRQRRFSSVSSTDSNPSLTDM SIDSAPVIHTQVSNTTNNGNSMQNLASASVSLSNSNPVYLSPFTQHRLSLKKRLISIY TQLSELKDFIELNQTGFSKICKKFDKSLNTNLKQNYLNYIKFHSHVFNPATINRIQHH ITETILTYASLNKGTRRPSNTFNLDADRINNDENSSGNEEDEDGNRQEVLDFQDAERE LSSHLRDHVVWERNTVWKDMMNLERKYQSAKTDNKKFSKLSSSQLRPNANITESMAMS SGGAGIIAPSTDSLTFRELMHLPPKQWLQFIMGQTSLLKFLLITSCFIALLTFNLTPF TQDSLQKNCFAILIYASLLWATETIPLFVTSLMIPLLIVVFPVIKDPITSQPMSPRDS SQFILSTMWSSVIMLLLGGFTLAAALSKYNIAKVLSTHILASAGTNPHFILLTNMFVA LFVSMWVSNVAAPVLCYSIVQPLLRTLPRNCSYAKALILGIALASNIGGMSSPIASPQ NIFSIGIMDPSPSWAEWFMIALPVCFICVMAIWVLLIITFPPEPNVKILQLHPSRDPF TLKQWFVTLVCIITIVLWCLSNQISGIFGEMGIISIIPIVVFFGTGLLTSDDFNNFMW TIVVLAMGGTTLGKAVSSSGLLSTMAQLIKAQVEHEPIFIIVLIFGLVILVMATFVSH TVAAMIIVPLMSEIGSNLPSGDHSRLLIVIAALLCSSAMGLPTSGFPNVTAISMIDEV GDRYLTVGTFITRGVPASLLSYAAIVTVGYGILKVMGF" gene 652465..653103 /locus_tag="YNR014W" mRNA 652465..653103 /locus_tag="YNR014W" /product="hypothetical protein" CDS 652465..653103 /locus_tag="YNR014W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /note="hypothetical protein; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10555.1" /db_xref="SGD:S000005297" /translation="MSSTDIKPCAVNIPVSAHITFHYKSIADRSSSRSSSSSSCSSAT SKACSPRGSSVGLPPALSTDNEIVETVLNVSAPVVADPTRPSLFKSNYTAASCLTSDP TSPSLLPSSRRNSVLPASDFHQCAHHKNFQRRASEPQLPSFDNRSSSEMKRSVSYAQH SMMFPISDQQEPQTSASPNDHSDPSCPCNRHHHRRNSVAVKFDKPLYERLET" gene 653387..654541 /gene="SMM1" /locus_tag="YNR015W" /gene_synonym="DUS2" mRNA 653387..654541 /gene="SMM1" /locus_tag="YNR015W" /gene_synonym="DUS2" /product="tRNA-dihydrouridine(20) synthase (NAD(+))" CDS 653387..654541 /gene="SMM1" /locus_tag="YNR015W" /gene_synonym="DUS2" /EC_number="1.3.1.91" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:12003496]" /experiment="EXISTENCE:direct assay:GO:0017150 tRNA dihydrouridine synthase activity [PMID:12003496]" /experiment="EXISTENCE:genetic interaction:GO:0008033 tRNA processing [PMID:12559567]" /experiment="EXISTENCE:mutant phenotype:GO:0006400 tRNA modification [PMID:14970222]" /experiment="EXISTENCE:mutant phenotype:GO:0017150 tRNA dihydrouridine synthase activity [PMID:14970222]" /note="Dihydrouridine synthase; member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of the D loop of cytoplasmic pre-tRNAs" /codon_start=1 /product="tRNA-dihydrouridine(20) synthase (NAD(+))" /protein_id="DAA10556.1" /db_xref="SGD:S000005298" /translation="MVTYAGKLVLAPMVRAGELPTRLMALAHGADLVWSPEIIDKKLI QCVRKENTALQTVDYVVPSKVQTRPETLVFRTYPKLESSKLIFQIGSASPALATQAAL KVINDVSGIDINAGCPKHFSIHSGMGSALLRTPDTLCLILKELVKNVGNPHSKPISVK IRLLDTKQDTLQLVKRLCATGITNLTVHCRKTEMRNREQPITDYIAEIYEICQANNVS LIVNGAIRDRSHFHDLQANHWKNTNIGGMIAECAERDPTVFDHTSKPSEDGPSWVVAC REFIQWATKFDNHIGNTKYMLSRIVPGKSVFFQYFARCKSPEEVSFVLKQLNDDGSAQ TDPSEYLENCRAQEKALKNANAIAKQKRKQTDHIGSDTKKQKVVPLPTDI" gene complement(654673..661374) /gene="ACC1" /locus_tag="YNR016C" /gene_synonym="ABP2" /gene_synonym="FAS3" /gene_synonym="MTR7" mRNA complement(654673..661374) /gene="ACC1" /locus_tag="YNR016C" /gene_synonym="ABP2" /gene_synonym="FAS3" /gene_synonym="MTR7" /product="acetyl-CoA carboxylase ACC1" CDS complement(654673..661374) /gene="ACC1" /locus_tag="YNR016C" /gene_synonym="ABP2" /gene_synonym="FAS3" /gene_synonym="MTR7" /EC_number="6.3.4.14" /EC_number="6.4.1.2" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9438137]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0003989 acetyl-CoA carboxylase activity [PMID:8098706]" /experiment="EXISTENCE:mutant phenotype:GO:0004075 biotin carboxylase activity [PMID:6108218]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:12730220]" /experiment="EXISTENCE:mutant phenotype:GO:0042759 long-chain fatty acid biosynthetic process [PMID:6103540]" /note="Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availability of acetyl-CoA; rate-limiting step for de novo biosynthesis of long-chain fatty acids; translational regulation in response to nutrients and cell cycle stage depends on its upstream ORF; ACC1 has a paralog, HFA1, that arose from the whole genome duplication" /codon_start=1 /product="acetyl-CoA carboxylase ACC1" /protein_id="DAA10557.1" /db_xref="SGD:S000005299" /translation="MSEESLFESSPQKMEYEITNYSERHTELPGHFIGLNTVDKLEES PLRDFVKSHGGHTVISKILIANNGIAAVKEIRSVRKWAYETFGDDRTVQFVAMATPED LEANAEYIRMADQYIEVPGGTNNNNYANVDLIVDIAERADVDAVWAGWGHASENPLLP EKLSQSKRKVIFIGPPGNAMRSLGDKISSTIVAQSAKVPCIPWSGTGVDTVHVDEKTG LVSVDDDIYQKGCCTSPEDGLQKAKRIGFPVMIKASEGGGGKGIRQVEREEDFIALYH QAANEIPGSPIFIMKLAGRARHLEVQLLADQYGTNISLFGRDCSVQRRHQKIIEEAPV TIAKAETFHEMEKAAVRLGKLVGYVSAGTVEYLYSHDDGKFYFLELNPRLQVEHPTTE MVSGVNLPAAQLQIAMGIPMHRISDIRTLYGMNPHSASEIDFEFKTQDATKKQRRPIP KGHCTACRITSEDPNDGFKPSGGTLHELNFRSSSNVWGYFSVGNNGNIHSFSDSQFGH IFAFGENRQASRKHMVVALKELSIRGDFRTTVEYLIKLLETEDFEDNTITTGWLDDLI THKMTAEKPDPTLAVICGAATKAFLASEEARHKYIESLQKGQVLSKDLLQTMFPVDFI HEGKRYKFTVAKSGNDRYTLFINGSKCDIILRQLSDGGLLIAIGGKSHTIYWKEEVAA TRLSVDSMTTLLEVENDPTQLRTPSPGKLVKFLVENGEHIIKGQPYAEIEVMKMQMPL VSQENGIVQLLKQPGSTIVAGDIMAIMTLDDPSKVKHALPFEGMLPDFGSPVIEGTKP AYKFKSLVSTLENILKGYDNQVIMNASLQQLIEVLRNPKLPYSEWKLHISALHSRLPA KLDEQMEELVARSLRRGAVFPARQLSKLIDMAVKNPEYNPDKLLGAVVEPLADIAHKY SNGLEAHEHSIFVHFLEEYYEVEKLFNGPNVREENIILKLRDENPKDLDKVALTVLSH SKVSAKNNLILAILKHYQPLCKLSSKVSAIFSTPLQHIVELESKATAKVALQAREILI QGALPSVKERTEQIEHILKSSVVKVAYGSSNPKRSEPDLNILKDLIDSNYVVFDVLLQ FLTHQDPVVTAAAAQVYIRRAYRAYTIGDIRVHEGVTVPIVEWKFQLPSAAFSTFPTV KSKMGMNRAVSVSDLSYVANSQSSPLREGILMAVDHLDDVDEILSQSLEVIPRHQSSS NGPAPDRSGSSASLSNVANVCVASTEGFESEEEILVRLREILDLNKQELINASIRRIT FMFGFKDGSYPKYYTFNGPNYNENETIRHIEPALAFQLELGRLSNFNIKPIFTDNRNI HVYEAVSKTSPLDKRFFTRGIIRTGHIRDDISIQEYLTSEANRLMSDILDNLEVTDTS NSDLNHIFINFIAVFDISPEDVEAAFGGFLERFGKRLLRLRVSSAEIRIIIKDPQTGA PVPLRALINNVSGYVIKTEMYTEVKNAKGEWVFKSLGKPGSMHLRPIATPYPVKEWLQ PKRYKAHLMGTTYVYDFPELFRQASSSQWKNFSADVKLTDDFFISNELIEDENGELTE VEREPGANAIGMVAFKITVKTPEYPRGRQFVVVANDITFKIGSFGPQEDEFFNKVTEY ARKRGIPRIYLAANSGARIGMAEEIVPLFQVAWNDAANPDKGFQYLYLTSEGMETLKK FDKENSVLTERTVINGEERFVIKTIIGSEDGLGVECLRGSGLIAGATSRAYHDIFTIT LVTCRSVGIGAYLVRLGQRAIQVEGQPIILTGAPAINKMLGREVYTSNLQLGGTQIMY NNGVSHLTAVDDLAGVEKIVEWMSYVPAKRNMPVPILETKDTWDRPVDFTPTNDETYD VRWMIEGRETESGFEYGLFDKGSFFETLSGWAKGVVVGRARLGGIPLGVIGVETRTVE NLIPADPANPNSAETLIQEPGQVWHPNSAFKTAQAINDFNNGEQLPMMILANWRGFSG GQRDMFNEVLKYGSFIVDALVDYKQPIIIYIPPTGELRGGSWVVVDPTINADQMEMYA DVNARAGVLEPQGMVGIKFRREKLLDTMNRLDDKYRELRSQLSNKSLAPEVHQQISKQ LADRERELLPIYGQISLQFADLHDRSSRMVAKGVISKELEWTEARRFFFWRLRRRLNE EYLIKRLSHQVGEASRLEKIARIRSWYPASVDHEDDRQVATWIEENYKTLDDKLKGLK LESFAQDLAKKIRSDHDNAIDGLSEVIKMLSTDDKEKLLKTLK" regulatory complement(661704..661715) /regulatory_class="other" /note="Upstream open reading frame (uORF) in 5' untranslated region of ACC1 gene, regulate translation" gene 662913..663581 /gene="TIM23" /locus_tag="YNR017W" /gene_synonym="MAS6" /gene_synonym="MIM23" /gene_synonym="MPI3" mRNA 662913..663581 /gene="TIM23" /locus_tag="YNR017W" /gene_synonym="MAS6" /gene_synonym="MIM23" /gene_synonym="MPI3" /product="protein transporter TIM23" CDS 662913..663581 /gene="TIM23" /locus_tag="YNR017W" /gene_synonym="MAS6" /gene_synonym="MIM23" /gene_synonym="MPI3" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:11713477]" /experiment="EXISTENCE:direct assay:GO:0030943 mitochondrion targeting sequence binding [PMID:8858146]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:7600576|PMID:10830167]" /experiment="EXISTENCE:mutant phenotype:GO:0030943 mitochondrion targeting sequence binding [PMID:8858146]" /experiment="EXISTENCE:physical interaction:GO:0005744 TIM23 mitochondrial import inner membrane translocase complex [PMID:7600576]" /note="Essential core component of the TIM23 complex; subunit of the translocase of the inner mitochondrial membrane involved in protein import into the mitochondrial matrix and inner membrane; provides a structural role, contributing to the architecture of the import channel; functions as a voltage sensor and pre-sequence receptor" /codon_start=1 /product="protein transporter TIM23" /protein_id="DAA10558.1" /db_xref="SGD:S000005300" /translation="MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNI ISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTG AVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYN IINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKR LLEK" gene 664270..664944 /gene="RCF2" /locus_tag="YNR018W" /gene_synonym="AIM38" mRNA 664270..664944 /gene="RCF2" /locus_tag="YNR018W" /gene_synonym="AIM38" /product="Rcf2p" CDS 664270..664944 /gene="RCF2" /locus_tag="YNR018W" /gene_synonym="AIM38" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:22342701]" /experiment="EXISTENCE:direct assay:GO:0031334 positive regulation of protein-containing complex assembly [PMID:38508182]" /experiment="EXISTENCE:direct assay:GO:0098803 respiratory chain complex [PMID:22310663|PMID:22342701]" /experiment="EXISTENCE:genetic interaction:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:22310663]" /note="Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; antagonistic with Min8p to control ETC assembly member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast" /codon_start=1 /product="Rcf2p" /protein_id="DAA10559.1" /db_xref="SGD:S000005301" /translation="MKILTQDEIEAHRSHTLKGGIEGALAGFAISAIIFKVLPRRYPK FKPSTLTWSIKTALWITPPTVLTAICAEEASNNFDATMYGSGSSSEDALDEHRRWKSL STKDKFVEGLSNNKYKIITGAWAASLYGSWVIVNKDPIMTKAQKIVQARMYAQFITVG LLLASVGLSMYENKLHPNKQKVNEMRRWENALRVAEEEERLEKEGRRTGYVSNEERIN SKIFKS" gene 665339..667267 /gene="ARE2" /locus_tag="YNR019W" /gene_synonym="SAT1" mRNA 665339..667267 /gene="ARE2" /locus_tag="YNR019W" /gene_synonym="SAT1" /product="sterol acyltransferase" CDS 665339..667267 /gene="ARE2" /locus_tag="YNR019W" /gene_synonym="SAT1" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:10672016]" /experiment="EXISTENCE:genetic interaction:GO:0008204 ergosterol metabolic process [PMID:10672016]" /experiment="EXISTENCE:genetic interaction:GO:0034737 ergosterol O-acyltransferase activity [PMID:10672016]" /experiment="EXISTENCE:mutant phenotype:GO:0008204 ergosterol metabolic process [PMID:10672016]" /experiment="EXISTENCE:mutant phenotype:GO:0034737 ergosterol O-acyltransferase activity [PMID:10672016]" /note="Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication" /codon_start=1 /product="sterol acyltransferase" /protein_id="DAA10560.1" /db_xref="SGD:S000005302" /translation="MDKKKDLLENEQFLRIQKLNAADAGKRQSITVDDEGELYGLDTS GNSPANEHTATTITQNHSVVASNGDVAFIPGTATEGNTEIVTEEVIETDDNMFKTHVK TLSSKEKARYRQGSSNFISYFDDMSFEHRPSILDGSVNEPFKTKFVGPTLEKEIRRRE KELMAMRKNLHHRKSSPDAVDSVGKNDGAAPTTVPTAATSETVVTVETTIISSNFSGL YVAFWMAIAFGAVKALIDYYYQHNGSFKDSEILKFMTTNLFTVASVDLLMYLSTYFVV GIQYLCKWGVLKWGTTGWIFTSIYEFLFVIFYMYLTENILKLHWLSKIFLFLHSLVLL MKMHSFAFYNGYLWGIKEELQFSKSALAKYKDSINDPKVIGALEKSCEFCSFELSSQS LSDQTQKFPNNISAKSFFWFTMFPTLIYQIEYPRTKEIRWSYVLEKICAIFGTIFLMM IDAQILMYPVAMRALAVRNSEWTGILDRLLKWVGLLVDIVPGFIVMYILDFYLIWDAI LNCVAELTRFGDRYFYGDWWNCVSWADFSRIWNIPVHKFLLRHVYHSSMSSFKLNKSQ ATLMTFFLSSVVHELAMYVIFKKLRFYLFFFQMLQMPLVALTNTKFMRNRTIIGNVIF WLGICMGPSVMCTLYLTF" gene complement(667410..668222) /gene="ATP23" /locus_tag="YNR020C" mRNA complement(667410..668222) /gene="ATP23" /locus_tag="YNR020C" /product="putative metalloprotease" CDS complement(667410..668222) /gene="ATP23" /locus_tag="YNR020C" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:17135288]" /experiment="EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:17135288]" /experiment="EXISTENCE:mutant phenotype:GO:0034982 mitochondrial protein processing [PMID:17135290|PMID:17135288]" /note="Putative metalloprotease of the mitochondrial inner membrane; required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p" /codon_start=1 /product="putative metalloprotease" /protein_id="DAA10561.1" /db_xref="SGD:S000005303" /translation="MTMRTNKKNKSSNIKMIRRVRHNLYNQNQGKLIVPNFFFFWHDM NSSGDNAGFEWWRRTMQYKTGIGLTPEEKTRYEDDSKARELKKECLKCYEYRDWMLKY SPTVRFMVQAITKLNKGSDSKFDDSKIICDYCPDWKGGGFHPELGILLCQNRLRDKWH LEDTLSHELIHYFDDLKWQIDWLNLKHHACSEIRASSLSGECRFWEEFKRRGFRTGFH VARGHQDCVRRRAIISVSGNPNCQSKEHAAKIVDEVWDSCFADTRPFDEIYR" gene 668377..669591 /locus_tag="YNR021W" mRNA 668377..669591 /locus_tag="YNR021W" /product="hypothetical protein" CDS 668377..669591 /locus_tag="YNR021W" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10562.1" /db_xref="SGD:S000005304" /translation="MSSSIFGPLTGFLERVNSLNAPYQALSYDEQKAMTIWQRVKFYN WTFELCALGVLFLVYAFYKFGNSVNLKRGNQIFQSLHSFLANDLKFSRVGFNINDSKI FTVEHQNTWFSSFATGRSAIKSINLNLHLVARSNPFSMCLEYLLGFFFASLKSKQLEE FMEIVIRPNGILVTSESAHPNKNAHEILTKFRFVTSIVNKEFMNQARTENYFLSIAHT SENDKLPNNFVYMSDVNQLSGFMFHYSKPYEVLSQAGNLLKYISFTDLPVNPPRDDKE WESSIEPKAIIRCAVPQNENELKLLNQIISLVVEIYDGFTQDLVQQSPNLFITNDILK RTTNLRQQELNKIKKFMKETELELAKEKKLELEKAKRRQLKASGQQEKVDQKMKEKRE RRLKNKQRTRFQ" gene complement(669774..670193) /gene="MRPL50" /locus_tag="YNR022C" /gene_synonym="bL9m" mRNA complement(669774..670193) /gene="MRPL50" /locus_tag="YNR022C" /gene_synonym="bL9m" /product="mitochondrial 54S ribosomal protein MRPL50" CDS complement(669774..670193) /gene="MRPL50" /locus_tag="YNR022C" /gene_synonym="bL9m" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation" /codon_start=1 /product="mitochondrial 54S ribosomal protein bL9m MRPL50" /protein_id="DAA10563.1" /db_xref="SGD:S000005305" /translation="MLHCTQVCLSALTKRTHRVKVQVLKDFPRFQLYKGQVANVKPSL MRNYLHNFNGAKYILSEEHDINTELLKQYQTLEAKLEEDHQQLSKRHETEVQKNMELR KESVFGHKKEEKPKEEKKGLLDSGITIEEVKIPGLDI" gene 670418..672118 /gene="SNF12" /locus_tag="YNR023W" /gene_synonym="SWP73" mRNA 670418..672118 /gene="SNF12" /locus_tag="YNR023W" /gene_synonym="SWP73" /product="Snf12p" CDS 670418..672118 /gene="SNF12" /locus_tag="YNR023W" /gene_synonym="SWP73" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:8127913|PMID:18644858]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8804308]" /experiment="EXISTENCE:mutant phenotype:GO:0000785 chromatin [PMID:28249159]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:28249159]" /experiment="EXISTENCE:mutant phenotype:GO:0030527 structural constituent of chromatin [PMID:28249159]" /experiment="EXISTENCE:mutant phenotype:GO:0034198 cellular response to amino acid starvation [PMID:10549298]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10549298|PMID:8816487]" /note="73 kDa subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive; SNF12 has a paralog, RSC6, that arose from the whole genome duplication" /codon_start=1 /product="Snf12p" /protein_id="DAA10564.1" /db_xref="SGD:S000005306" /translation="MSKVMKPSNGKGSRKSSKAATPDTKNFFHAKKKDPVNQDKANNA SQITPTVPHSHPSDMVIPDHLAELIPELYSFQQLVDSEKRLDHFIHLRNLHMKRMVAQ WERSKLSQEFLYPHLNFPNVKFLRIFISNVSENQPWQMDTNNEADLMALENATWTMRI EGRLLDNVQANDPAREKFSSFIESIVVDFKNKENDNVPSTKFNAAPEENATEGPSDKK LNLNLPLQFSLPNGDNSTTTNTDQNNATMGEETAKKDMSSTTPKLESVKWQYDPNNPV DFDGLDIKRVGSENVECTISILRKSSPEEPFMSYSPQLTAIIGLKSGTSHDAIFSIYK YIHLNELLTNDESAFENLMGNRNNHNSNTSTSKMLDAASSQVSIVKLDTQLITLLPSS LKESSPDTMKLTDLLSLINSTHLLPLQPIEIDYTVRVDKASTYGELVLDIEVPDVNAL KFNNTQRESQIGAAELNENARELEQIKPKIALQDKEITSVLSNLHESNKRYRFFKKIS EDPVKALNECIASTSNALKVLSGDEGYNEDMVRRANFYKENEAMLRENIEVILSNGRM " gene 672409..672969 /gene="MPP6" /locus_tag="YNR024W" mRNA 672409..672969 /gene="MPP6" /locus_tag="YNR024W" /product="Mpp6p" CDS 672409..672969 /gene="MPP6" /locus_tag="YNR024W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095|PMID:18591258]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0008266 poly(U) RNA binding [PMID:18591258]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:18591258|PMID:19046973]" /experiment="EXISTENCE:genetic interaction:GO:0071030 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing [PMID:18591258]" /experiment="EXISTENCE:genetic interaction:GO:0071031 nuclear mRNA surveillance of mRNA 3'-end processing [PMID:18591258]" /experiment="EXISTENCE:genetic interaction:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:18591258]" /experiment="EXISTENCE:genetic interaction:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:18591258]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:18591258]" /experiment="EXISTENCE:mutant phenotype:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:18591258]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27076633]" /note="Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes; relocalizes to the cytosol in response to hypoxia" /codon_start=1 /product="Mpp6p" /protein_id="DAA10565.1" /db_xref="SGD:S000005307" /translation="MSANNGVTGKLSSRVMNMKFMKFGKTDDEESSNSNTPSNINSDV EPIEQKGKLFGLDDSAWDLNSYKDDLKKISGKEKKKVKRVVYKKRPNLIISNVGYSEL RKPEGVISGRKTFGDNSDDSGSRKRKFDEGEQNEDEKRDAKDKEFTGSQDDGEDEYDL DKLFKDSIKKKKTNHNGKNKNRNSKK" gene complement(673274..674689) /gene="SEC12" /locus_tag="YNR026C" /gene_synonym="SED2" mRNA complement(673274..674689) /gene="SEC12" /locus_tag="YNR026C" /gene_synonym="SED2" /product="Sar family guanine nucleotide exchange factor SEC12" CDS complement(673274..674689) /gene="SEC12" /locus_tag="YNR026C" /gene_synonym="SED2" /experiment="EXISTENCE:direct assay:GO:0003400 regulation of COPII vesicle coating [PMID:8377826]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:8583945|PMID:8377826]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:8707815|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:3047151]" /experiment="EXISTENCE:mutant phenotype:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:8377826]" /note="Guanine nucleotide exchange factor (GEF); activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER; SEC12 has a paralog, SED4, that arose from the whole genome duplication" /codon_start=1 /product="Sar family guanine nucleotide exchange factor SEC12" /protein_id="DAA10566.1" /db_xref="SGD:S000005309" /translation="MKFVTASYNVGYPAYGAKFLNNDTLLVAGGGGEGNNGIPNKLTV LRVDPTKDTEKEQFHILSEFALEDNDDSPTAIDASKGIILVGCNENSTKITQGKGNKH LRKFKYDKVNDQLEFLTSVDFDASTNADDYTKLVYISREGTVAAIASSKVPAIMRIID PSDLTEKFEIETRGEVKDLHFSTDGKVVAYITGSSLEVISTVTGSCIARKTDFDKNWS LSKINFIADDTVLIAASLKKGKGIVLTKISIKSGNTSVLRSKQVTNRFKGITSMDVDM KGELAVLASNDNSIALVKLKDLSMSKIFKQAHSFAITEVTISPDSTYVASVSAANTIH IIKLPLNYANYTSMKQKISKFFTNFILIVLLSYILQFSYKHNLHSMLFNYAKDNFLTK RDTISSPYVVDEDLHQTTLFGNHGTKTSVPSVDSIKVHGVHETSSVNGTEVLCTESNI INTGGAEFEITNATFREIDDA" gene 674923..675876 /gene="BUD17" /locus_tag="YNR027W" mRNA 674923..675876 /gene="BUD17" /locus_tag="YNR027W" /product="putative pyridoxal kinase BUD17" CDS 674923..675876 /gene="BUD17" /locus_tag="YNR027W" /EC_number="2.7.1.35" /experiment="EXISTENCE:curator inference:GO:0042823 pyridoxal phosphate biosynthetic process [PMID:9099727]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Putative pyridoxal kinase; a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)" /codon_start=1 /product="putative pyridoxal kinase BUD17" /protein_id="DAA10567.1" /db_xref="SGD:S000005310" /translation="MTSTLHTTKKVLSIQSHVIHGYVGNKAATFPLQYRGWDVDVLNT VQFSNHSGYAHFTGFKCSTEELVDIVEKGLIGSLRIKYDAVLSGYLPNVQALQKVAGI VGQLCEGSENVKWILDPVLGDNGRLYVDRECVAVYQDILQNFKIFLATPNQFEMELLV GMSIRTLDDAKQAFKLFHKKYPRVSRIVVTSLELSEFLSNDTYVVAGFDCSASEEIFF YEIPKINAKFSGSGDLISAMLTDSLLGDRRCTQLSLSASLGQVLWLVTSILQKTYDLN IAERGPQDSTIDIKDLKLIQCRDILKQDLIPSIGKPKTIKI" gene 676177..677103 /gene="CPR8" /locus_tag="YNR028W" mRNA 676177..677103 /gene="CPR8" /locus_tag="YNR028W" /product="peptidylprolyl isomerase family protein CPR8" CDS 676177..677103 /gene="CPR8" /locus_tag="YNR028W" /EC_number="5.2.1.8" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /note="Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; CPR8 has a paralog, CPR4, that arose from the whole genome duplication" /codon_start=1 /product="peptidylprolyl isomerase family protein CPR8" /protein_id="DAA10568.1" /db_xref="SGD:S000005311" /translation="MKSFFLYLYVAFMFSCITALPLPVDNKRASSDSLDLKKKYAPDP PITHNVNIGIVFTDPESSEEAGRLITIDLYGTMVPKTVMTFCQYVDSVKDRLASRHSY SPERDFDKILPNGAIEGSSVSSSSIEETEMLAPKLPEENHSLIHDRPGRVSMIKDDKG LKFIIETSETPLEGESVVFGQVTAGLKDLMDKLANVKTDENGKPEQPITIGYISSQEH RIQHAKEAHEKYLQRLQDYQNGDLEKGITLKNYLYQGSQRKLEDAKYNQLHHPLPKIM LGISVLLLFYVLAKYRKRIFNRSSKIVSIRED" gene complement(677199..678488) /gene="ZNG1" /locus_tag="YNR029C" mRNA complement(677199..678488) /gene="ZNG1" /locus_tag="YNR029C" /product="GTP-dependent zinc transferase" CDS complement(677199..678488) /gene="ZNG1" /locus_tag="YNR029C" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:35584675]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:35584675]" /experiment="EXISTENCE:direct assay:GO:0140827 zinc chaperone activity [PMID:35584675]" /experiment="EXISTENCE:genetic interaction:GO:0034224 cellular response to zinc ion starvation [PMID:35584675]" /experiment="EXISTENCE:genetic interaction:GO:0051604 protein maturation [PMID:35584675]" /experiment="EXISTENCE:mutant phenotype:GO:0034224 cellular response to zinc ion starvation [PMID:35584675]" /experiment="EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:35584675]" /note="GTP-dependent zinc transferase; couples GTP hydrolysis to the activation of methionine aminopeptidase Map1p, especially during zinc starvation; deletion confers reduced fitness in saline; contains GTPase sequence motifs and a CxCC metal-binding motif" /codon_start=1 /product="GTP-dependent zinc transferase" /protein_id="DAA10569.1" /db_xref="SGD:S000005312" /translation="MSALRNIKFNEEEDGELPCLVTGEENNLQEILENVSYDGGNIVS DAKVERVNKQVENTSAGATDVHEKKRIPVSIITGYLGSGKSTLLEKIALKGADKKIAV ILNEFGDSSEIEKAMTIKNGSNSYQEWLDLGNGCLCCSLKNIGVKAIEDMVERSPGKI DYILLETSGIADPAPIAKMFWQDEGLNSSVYIDGIITVLDCEHILKCLDDISIDAHWH GDKVGLEGNLTIAHFQLAMADRIIMNKYDTIEHSPEMVKQLKERVREINSIAPMFFTK YSDTPIQNLLDIHAYDSVRISDILDSGSGNGTIHDDRMGTIMLTFRPLKNEEEYNNKF IKQFLQPLLWKNFGAMTVLGGRRRDDGRDWEVQRTKGLILIEGENPIARVIQGVRDTY DVFPGKYDGSNKECKIVLIGKYLEKESIEELLRKTLE" gene 678799..680454 /gene="ALG12" /locus_tag="YNR030W" /gene_synonym="ECM39" mRNA 678799..680454 /gene="ALG12" /locus_tag="YNR030W" /gene_synonym="ECM39" /product="dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase" CDS 678799..680454 /gene="ALG12" /locus_tag="YNR030W" /gene_synonym="ECM39" /EC_number="2.4.1.260" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:10336995]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:12460938|PMID:10336995]" /experiment="EXISTENCE:mutant phenotype:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:10336995]" /note="Alpha-1,6-mannosyltransferase localized to the ER; responsible for addition of alpha-1,6 mannose to dolichol-linked Man7GlcNAc2; acts in the dolichol pathway for N-glycosylation; human homolog ALG12 complements yeast null mutant" /codon_start=1 /product="dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase" /protein_id="DAA10570.1" /db_xref="SGD:S000005313" /translation="MRWSVLDTVLLTVISFHLIQAPFTKVEESFNIQAIHDILTYSVF DISQYDHLKFPGVVPRTFVGAVIIAMLSRPYLYLSSLIQTSRPTSIDVQLVVRGIVGL TNGLSFIYLKNCLQDMFDEITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLMFYST RTLPNFVMTLPLTNVALGWVLLGRYNAAIFLSALVAIVFRLEVSALSAGIALFSVIFK KISLFDAIKFGIFGLGLGSAISITVDSYFWQEWCLPEVDGFLFNVVAGYASKWGVEPV TAYFTHYLRMMFMPPTVLLLNYFGYKLAPAKLKIVSLASLFHIIVLSFQPHKEWRFII YAVPSIMLLGATGAAHLWENMKVKKITNVLCLAILPLSIMTSFFISMAFLYISRMNYP GGEALTSFNDMIVEKNITNATVHISIPPCMTGVTLFGELNYGVYGINYDKTENTTLLQ EMWPSFDFLITHEPTASQLPFENKTTNHWELVNTTKMFTGFDPTYIKNFVFQERVNVL SLLKQIIFDKTPTVFLKELTANSIVKSDVFFTYKRIKQDEKTD" gene complement(680694..685433) /gene="SSK2" /locus_tag="YNR031C" mRNA complement(680694..685433) /gene="SSK2" /locus_tag="YNR031C" /product="mitogen-activated protein kinase kinase kinase SSK2" CDS complement(680694..685433) /gene="SSK2" /locus_tag="YNR031C" /EC_number="2.7.11.25" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:12857882]" /experiment="EXISTENCE:direct assay:GO:0003779 actin binding [PMID:12181352]" /experiment="EXISTENCE:direct assay:GO:0004709 MAP kinase kinase kinase activity [PMID:9482735]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12181352]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12857882]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12857882|PMID:12181352]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:12181352|PMID:12857882]" /experiment="EXISTENCE:direct assay:GO:0071474 cellular hyperosmotic response [PMID:12181352|PMID:9482735]" /experiment="EXISTENCE:genetic interaction:GO:0007234 osmosensory signaling via phosphorelay pathway [PMID:9482735]" /experiment="EXISTENCE:genetic interaction:GO:0032956 regulation of actin cytoskeleton organization [PMID:12857882]" /experiment="EXISTENCE:genetic interaction:GO:0038066 p38MAPK cascade [PMID:7624781|PMID:9742096]" /experiment="EXISTENCE:genetic interaction:GO:0071474 cellular hyperosmotic response [PMID:12857882]" /experiment="EXISTENCE:mutant phenotype:GO:0032956 regulation of actin cytoskeleton organization [PMID:12857882|PMID:12181352]" /experiment="EXISTENCE:mutant phenotype:GO:0038066 p38MAPK cascade [PMID:7624781]" /experiment="EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:12857882|PMID:12181352]" /experiment="EXISTENCE:physical interaction:GO:0007234 osmosensory signaling via phosphorelay pathway [PMID:9482735]" /note="MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress; a HOG-independent function of Ssk2p mediates the calcium-sensitive phenotype of the ptp2 msg5 double disruptant; SSK2 has a paralog, SSK22, that arose from the whole genome duplication" /codon_start=1 /product="mitogen-activated protein kinase kinase kinase SSK2" /protein_id="DAA10571.1" /db_xref="SGD:S000005314" /translation="MSHSDYFNYKPYGDSTEKPSSSKMRQSSSSSSSRLRSESLGRNS NTTQARVASSPISPGLHSTQYFRSPNAVYSPGESPLNTVQLFNRLPGIPQGQFFHQNA ISGSSSSSARSSRRPSNIGLPLPKNPQQSLPKLSTQPVPVHKKVEASKTESEIIKKPA PVNSNQDPLLTTPTLVISPELASLNTTNTSIMSTPQNITNQTSNKHIPTRSQPNGSTS SSTLQDIVTTNSSQRSVGHHGGSTTSLRTYKKQYVLNEQLYLRKMRNRANDDYYTRGI VASSNFEDDEENFSNKGEDDLELEMDDLLKVEGEDKDNDFNFGYNFITSSTKNNENVV SMSLNYLKGKLDWLRDVNNDQPCEIEDEEWHSILGSEDLLSKLLQNPMVNNRFEWQTM LSKVLKGDIVRNEKTKIANQGKGPGFNTQFSDDIWIELKAWMNGRTVEDQNKSLRIFR DSTDSVFQEIMAFKLEDNMSADEAAETIKSLVDKYYRVLNLWPNIKRMHAEKPITKTE AFRNRIDTLNSWLNFKFNFDTNIAYLKKWIVGNKELESTTEVDNTTVNLDDPAVFATN CKRFAEQIMKEKDIELIFQKKIFFPLAPWILKAKFFFLKYQKTWNELNLSYLDQDLEF LLMFPMRLVKDIILIRLSYAKKIQNPTLMMIDQMMDDFSTYIKLAVQMKFTVASYCND WFFKVKIDPEFDHTVVEGLEYFFSILELRILYSGKNSFKTSKEPDLLLKYWEMFRNVG YYIDDAGELIAAEFTKLTLRLVHRLHAYLLRQQNTPPKLENEAAAEKWLVQIFEILGS MKRKLNRFTNILTKAFQNFVRYKIEDHNYLLKQLKETGHFLIYTGGYLEQNGTYLIGS PELLGCKDDDILRIIKNSDIGCDLVPKLEINNSLTIYNALDDNWNSNSSLGSDISNDG TPFYYIKNDLTTQPRSYNGNRVNREPDFENSRSTEEEFYELETRLNSLGYVLVLTPQE PLLWEGEMYNLSDNKTIKPEGLNLKVIPNSIDLMCQGSSYALEYQCDRFQQISGSSVS FLEKKSSSETVKNNLQRINKAYFRCTYSVLKNYTKIVTTFKKVSPVNDLLNNIFLFGR DFGLNFLRINVANNEKRSIIILLMMRLSIGWLKFLAEDCDPTDQRVFRWCVTSMEFAM HMVSGWNILALDECQFSSLKQKISECMSLLISHFDIIGARSIEVEKINQQARSNLDLE DVFDDDMMLQVNSEFRVQSIMELEERIKRNPHQTGKVIDDSDKGNKYLVSLASSISNV SMRWQKRNFIGGGTFGRVYSAVDLDNGEILAVKEINIQDSKSMQKIFPLIKEEMSVLE ILNHPNIVSYYGVEVHRDKVNIFMEYCEGGSLAALLEHGRIEDEMVTQVYTLQLLEGL AYLHESGIVHRDVKPENILLDFNGVIKYVDFGAAKKIANNGTRLASMNKIENADGEHE DVTHVSDSKAVKNNENALLDMMGTPMYMAPESITGSTTKGKLGADDVWSLGCVVLEMI TGRRPWANLDNEWAIMYHVAAGHTPQFPTKDEVSSAGMKFLERCLIQNPSKRASAVEL LMDPWIVQIREIAFGDDSSSTDTEERE" gene 686010..687116 /gene="PPG1" /locus_tag="YNR032W" mRNA 686010..687116 /gene="PPG1" /locus_tag="YNR032W" /product="putative serine/threonine-protein kinase PPG1" CDS 686010..687116 /gene="PPG1" /locus_tag="YNR032W" /EC_number="3.1.3.16" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:33317697]" /experiment="EXISTENCE:mutant phenotype:GO:0004722 protein serine/threonine phosphatase activity [PMID:33317697]" /experiment="EXISTENCE:mutant phenotype:GO:0005977 glycogen metabolic process [PMID:7678255]" /experiment="EXISTENCE:mutant phenotype:GO:1901525 negative regulation of mitophagy [PMID:33317697]" /note="Serine protein phosphatase involved in formation of FAR complex; inhibits mitophagy by dephosphorylating Atg32p; required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases" /codon_start=1 /product="putative serine/threonine-protein kinase PPG1" /protein_id="DAA10572.1" /db_xref="SGD:S000005315" /translation="MELDECLERLYKAQLLPEVTVRALCFKLKEMLVKESNVIHIQTP VTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPS RIHLLRGNHESRQITQSYGFYTECLNKYGGNSRVWQYLTDIFDYLVLCCIIDDEIFCV HGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPEENNNPTLDHPDNSGQHFQVS PRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCG NKASILELYSKDQFYFNVFEEAPENKLLKENSMNDNALEDSISNPVANRKLIADYFED DSASADGSTDPEMYIFSDVYQARSASNRHVDYFL" gene complement(687243..687464) /gene="HUB1" /locus_tag="YNR032C-A" mRNA complement(687243..687464) /gene="HUB1" /locus_tag="YNR032C-A" /product="ubiquitin-like protein HUB1" CDS complement(687243..687464) /gene="HUB1" /locus_tag="YNR032C-A" /experiment="EXISTENCE:direct assay:GO:0031386 protein tag activity [PMID:11923536]" /experiment="EXISTENCE:direct assay:GO:0043687 post-translational protein modification [PMID:11923536]" /experiment="EXISTENCE:mutant phenotype:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:11923536]" /experiment="EXISTENCE:mutant phenotype:GO:0033120 positive regulation of RNA splicing [PMID:31666190]" /experiment="EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:15620657]" /note="Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear" /codon_start=1 /product="ubiquitin-like protein HUB1" /protein_id="DAA10573.1" /db_xref="SGD:S000007251" /translation="MIEVVVNDRLGKKVRVKCLAEDSVGDFKKVLSLQIGTQPNKIVL QKGGSVLKDHISLEDYEVHDQTNLELYYL" gene 687635..689998 /gene="ABZ1" /locus_tag="YNR033W" mRNA 687635..689998 /gene="ABZ1" /locus_tag="YNR033W" /product="4-amino-4-deoxychorismate synthase" CDS 687635..689998 /gene="ABZ1" /locus_tag="YNR033W" /EC_number="2.6.1.85" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0008153 4-aminobenzoate biosynthetic process [PMID:8346682]" /experiment="EXISTENCE:mutant phenotype:GO:0046820 4-amino-4-deoxychorismate synthase activity [PMID:8346682]" /note="Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="4-amino-4-deoxychorismate synthase" /protein_id="DAA10574.1" /db_xref="SGD:S000005316" /translation="MLSDTIDTKQQQQQLHVLFIDSYDSFTYNVVRLIEQQTDISPGV NAVHVTTVHSDTFQSMDQLLPLLPLFDAIVVGPGPGNPNNGAQDMGIISELFENANGK LDEVPILGICLGFQAMCLAQGADVSELNTIKHGQVYEMHLNDAARACGLFSGYPDTFK STRYHSLHVNAEGIDTLLPLCTTEDENGILLMSAQTKNKPWFGVQYHPESCCSELGGL LVSNFLKLSFINNVKTGRWEKKKLNGEFSDILSRLDRTIDRDPIYKVKEKYPKGEDTT YVKQFEVSEDPKLTFEICNIIREEKFVMSSSVISENTGEWSIIALPNSASQVFTHYGA MKKTTVHYWQDSEISYTLLKKCLDGQDSDLPGSLEVIHEDKSQFWITLGKFMENKIID NHREIPFIGGLVGILGYEIGQYIACGRCNDDENSLVPDAKLVFINNSIVINHKQGKLY CISLDNTFPVALEQSLRDSFVRKKNIKQSLSWPKYLPEEIDFIITMPDKLDYAKAFKK CQDYMHKGDSYEMCLTTQTKVVPSAVIEPWRIFQTLVQRNPAPFSSFFEFKDIIPRQD ETPPVLCFLSTSPERFLKWDADTCELRPIKGTVKKGPQMNLAKATRILKTPKEFGENL MILDLIRNDLYELVPDVRVEEFMSVQEYATVYQLVSVVKAHGLTSASKKTRYSGIDVL KHSLPPGSMTGAPKKITVQLLQDKIESKLNKHVNGGARGVYSGVTGYWSVNSNGDWSV NIRCMYSYNGGTSWQLGAGGAITVLSTLDGELEEMYNKLESNLQIFM" gene 690321..691286 /gene="SOL1" /locus_tag="YNR034W" mRNA 690321..691286 /gene="SOL1" /locus_tag="YNR034W" /product="Sol1p" CDS 690321..691286 /gene="SOL1" /locus_tag="YNR034W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15454531|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:15454531]" /note="Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="Sol1p" /protein_id="DAA10575.1" /db_xref="SGD:S000005317" /translation="MTTTVPKVFAFHEFAGVAEAVADHVIHAQNSALKKGKVSRSTQM SGTSLNGNGNTESKTMERVNSVRSNASSRGGSEDGATKKLKKEKERRFKIALSGGSLI QVLHEGLLKRDDVQWGKWDIYFADERLVPFSSSESNYGLAKRKIFDLIDTEKYGTPKI YHIDESLINDPQECADNYEKILIKGFAGRDSVKLPMFDLFLLGCAPDGHIASLFPNFQ ENLRENLAWVIPVENAPSGPSNRISLTIPVICHSHRVTFVVEGATKAPVIKTIMERPE KGLPSSIVNEGAAGRVSWFVDDDALKDVFVIKKKYKFYDDENLTE" rep_origin 691486..691730 /note="ARS1427; Autonomously Replicating Sequence" /db_xref="SGD:S000118393" gene 692561..692857 /gene="EGO4" /locus_tag="YNR034W-A" mRNA 692561..692857 /gene="EGO4" /locus_tag="YNR034W-A" /product="Ego4p" CDS 692561..692857 /gene="EGO4" /locus_tag="YNR034W-A" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26206314]" /note="hypothetical protein; expressed during diauxic shift and stationary phase, and negatively regulated by glucose; expression is regulated by Msn2p/Msn4p; overexpression slows down progression through meiosis and improves fermentative efficiency; YNR034W-A has a paralog, YCR075W-A, that arose from the whole genome duplication" /codon_start=1 /product="Ego4p" /protein_id="DAA10576.1" /db_xref="SGD:S000007525" /translation="MKSSIPITEVLPRAVGSLTFDENYNLLDTSGVAKVIEKSPIAEI IRKSNAELGRLGYSVYEDAQYIGHAFKKAGHFIVYFTPKNKNREGVVPPVGITN" gene complement(693019..694047) /gene="ARC35" /locus_tag="YNR035C" /gene_synonym="END9" mRNA complement(693019..694047) /gene="ARC35" /locus_tag="YNR035C" /gene_synonym="END9" /product="Arc35p" CDS complement(693019..694047) /gene="ARC35" /locus_tag="YNR035C" /gene_synonym="END9" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:14554195]" /experiment="EXISTENCE:direct assay:GO:0005885 Arp2/3 protein complex [PMID:10377407|PMID:9210376]" /experiment="EXISTENCE:mutant phenotype:GO:0000226 microtubule cytoskeleton organization [PMID:14554195]" /experiment="EXISTENCE:mutant phenotype:GO:0006898 receptor-mediated endocytosis [PMID:7929582]" /experiment="EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:14554195]" /experiment="EXISTENCE:mutant phenotype:GO:0044396 actin cortical patch organization [PMID:10377407]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:10377407]" /experiment="EXISTENCE:mutant phenotype:GO:0072697 protein localization to cell cortex [PMID:10749918]" /experiment="EXISTENCE:physical interaction:GO:0005516 calmodulin binding [PMID:10749918]" /note="Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin" /codon_start=1 /product="Arc35p" /protein_id="DAA10577.1" /db_xref="SGD:S000005318" /translation="MLHLQPQNLLIQKTLNEAIEALRKGSPLTMDRIVSDFDYTTYHI SNTAEDKSILLLSVKTKAWVSVSECQLDGSLTLLKFLADHYSSLGGVTIPSEVEPGYD YTLQITLAELVQESILQLSVLKTIILSFPFELAISKFIELSQQQPAPVEAEITGGEVA ANGDNTLFTIKYRDEENIFIKPSNDRVTIIFETIFQDETDKIFGKVFLQEFVDARKRN RQIQSAPQVLYSHEPPLELKRLYQPPKVAEQSRRFITFVLFPRHFQTKELQFHSICQL TLFRNYFHYHIKCSKAYMHSRMRFRVDSFIKVLNRAKVDEDDENDELSAEGRQQARRT FTGRKIVY" gene complement(694361..694822) /gene="MRPS12" /locus_tag="YNR036C" /gene_synonym="uS12m" mRNA complement(694361..694822) /gene="MRPS12" /locus_tag="YNR036C" /gene_synonym="uS12m" /product="putative mitochondrial 37S ribosomal protein MRPS12" CDS complement(694361..694822) /gene="MRPS12" /locus_tag="YNR036C" /gene_synonym="uS12m" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:30520011]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:28154081]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:28154081]" /note="Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins" /codon_start=1 /product="mitochondrial 37S ribosomal protein uS12m MRPS12" /protein_id="DAA10578.1" /db_xref="SGD:S000005319" /translation="MLSRFMSNTWCTPLRQAQRLFSSTTTMQATLNQIKRGSGPPRRK KISTAPQLDQCPQRKGVVLRVMVLKPKKPNSAQRKACRVRLTNGNVVSAYIPGEGHDA QEHSIVYVRGGRCQDLPGVKYHVIRGAGDLSGVVNRISSRSKYGAKKPSKS" gene complement(695052..695327) /gene="RSM19" /locus_tag="YNR037C" /gene_synonym="uS19m" mRNA complement(695052..695327) /gene="RSM19" /locus_tag="YNR037C" /gene_synonym="uS19m" /product="mitochondrial 37S ribosomal protein RSM19" CDS complement(695052..695327) /gene="RSM19" /locus_tag="YNR037C" /gene_synonym="uS19m" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S19 ribosomal protein" /codon_start=1 /product="mitochondrial 37S ribosomal protein uS19m RSM19" /protein_id="DAA10579.1" /db_xref="SGD:S000005320" /translation="MQPAARLLSRSVWKGPNIVPLPIREAMTKGTPIRTNARAATILP QFVGLKFQIHNGKEYVPIEISEDMVGHKLGEFAPTRKRFSYTQTKNK" gene 695595..697484 /gene="DBP6" /locus_tag="YNR038W" mRNA 695595..697484 /gene="DBP6" /locus_tag="YNR038W" /product="putative ATP-dependent RNA helicase DBP6" CDS 695595..697484 /gene="DBP6" /locus_tag="YNR038W" /EC_number="3.6.4.13" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9528757]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17145778|PMID:15126390]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9528757]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9528757]" /note="Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family; human homolog DDX51 complements yeast dbp6 mutant" /codon_start=1 /product="putative ATP-dependent RNA helicase DBP6" /protein_id="DAA10580.1" /db_xref="SGD:S000005321" /translation="MFASRFDPSQLTAPAASAPEGIVGTTPPAIVPLKRQATESDNEE YGSHQDSDESSNSSSEEDEDRMQVDYGASEEDSSEVEEEESKPSTHSTVLSRFKQTVS LQERLGASDIAESKEDEGIEDEAASTHQLKQIPQPEFVKNPMNLNTNSLQFKSTGWLN TEKIYYDNSLIKPFSDYANELEAKLLQNICKNFSTNTFPIQSIILDSILPVLNFTLNV SKRNFTRRIGDILVNAATGSGKTLAYSIPIVQTLFKRQINRLRCIIIVPTKLLINQVY TTLTKLTQGTSLIVSIAKLENSLKDEHKKLSNLEPDILITTPGRLVDHLNMKSINLKN LKFLIIDEADRLLNQSFQGWCPKLMSHLKTDKLDTLPGNVIKMIFSATLTTNTEKLNG LNLYKPKLFLKQTDKLYQLPNKLNEFNINIPTAKSVYKPLILLYSICQFMAHSPIAAK ILIFVKSNESSIRLSKLLQLICESRSQSSVLKNLQNLAVSINSVNSNNSKAENKKIVA NFSHHSESAGITILITTDIMSRGIDINDITQVINYDPPMSSQQYVHRVGRTARANELG SAYNLLVGRGERTFFDDLNKDLDRDGKSVQPLELDFTLLESDSELYTSSLESLKNYHN NTAQA" gene complement(697614..699431) /gene="ZRG17" /locus_tag="YNR039C" mRNA complement(697614..699431) /gene="ZRG17" /locus_tag="YNR039C" /product="Zn(2+) transporter ZRG17" CDS complement(697614..699431) /gene="ZRG17" /locus_tag="YNR039C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:15961382|PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0005385 zinc ion transmembrane transporter activity [PMID:15961382]" /experiment="EXISTENCE:genetic interaction:GO:0006829 zinc ion transport [PMID:15961382]" /experiment="EXISTENCE:mutant phenotype:GO:0005385 zinc ion transmembrane transporter activity [PMID:15961382]" /experiment="EXISTENCE:mutant phenotype:GO:0006829 zinc ion transport [PMID:15961382|PMID:10978274]" /note="Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency" /codon_start=1 /product="Zn(2+) transporter ZRG17" /protein_id="DAA10581.1" /db_xref="SGD:S000005322" /translation="METPQMNAIQEEDNLSPEVAFQTPKLNDSDASSFSLSNMNAVGN VDGIPSQNRTFFASPRPSSLFYSAKEGNNSSSSIIYNPSFTFGENASSNANINEAALM KGKGNEGRRQSLKYIPAPKLVPPPPRTRSPVRGISPDAGSSKRSSMTLDSPFNFTTST LQPHQQTPPSSAASRTSFRKGHRYKHSSVSMNFFQEPEVKIPLNIAKSLPIPDFNDLL SNLPWPKAYIQLSIAALQIFACLITFQVGHLYSWSNFITLSHFITYDIIGSLVIIFVE NLSQFQVWFTGTITFPFGLNRIDVLLSFALAVSLCFVGLDLLFHIIEEFIVLFVESGS SLTNNHDHDEINEQIPHSHIANANDSQNENITLWYSILMINLVLSTLSLYKTFYANKY SNLKTKNPIITITYTAYLFIYPLLLDLLSSISDYLATLVISSLILWHGLTIARWTSTV LLMGFSTTSLSNSALFNNNDSTDTTAHTQQVESKAAKEKPSVRPRSMSSLPIATKNTK IRKTGFLNSAGFTENPTTIKNMIKDQIERLSEFKSRYILNYDDIVISKVNFTLYVVLI KITMKGGSDDDELMLRLAIDKCIQTSIPTCETTIDIDRI" gene 699690..700460 /gene="MRX15" /locus_tag="YNR040W" /gene_synonym="DPI29" mRNA 699690..700460 /gene="MRX15" /locus_tag="YNR040W" /gene_synonym="DPI29" /product="Mrx15p" CDS 699690..700460 /gene="MRX15" /locus_tag="YNR040W" /gene_synonym="DPI29" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:30091672]" /experiment="EXISTENCE:direct assay:GO:0097177 mitochondrial ribosome binding [PMID:30091672]" /experiment="EXISTENCE:genetic interaction:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:30091672]" /experiment="EXISTENCE:mutant phenotype:GO:0097177 mitochondrial ribosome binding [PMID:30091672]" /note="Membrane-associated mitoribosome receptor; involved along with Mba1p in the cotranslational insertion of nascent polypeptide chains into the inner mitochondrial membrane; associates with the mitochondrial large ribosomal subunit and nascent polypeptide chains; null mutant displays increased tolerance to mistranslation-induced proteotoxic stress; localizes to the inner mitochondrial membrane" /codon_start=1 /product="Mrx15p" /protein_id="DAA10582.1" /db_xref="SGD:S000005323" /translation="MTNMAAKNQFKGSSFTLAQLIEEVGRNGGKKPVFQYKVPRSIRW ASTALAVVFLTYGAAYTDMSWRTAREVYGNATEEEKHSPWFKCKTFGPVALGVLPVIL AAATKHVTSRLVTEMKYLPPLKNSTVPRCQLTRRTYLLGRPVSITREINELSKNKATK IFTGVGSQGMEDKATFVFFTVDEKAPSFFNKFYIFSRSGSVVKNDARILDCFFNSVAE NKLLNRSILTQILSHTSAKTLFHSGNSRSSIKNIVKPK" gene complement(700541..701659) /gene="COQ2" /locus_tag="YNR041C" mRNA complement(700541..701659) /gene="COQ2" /locus_tag="YNR041C" /product="4-hydroxybenzoate octaprenyltransferase" CDS complement(700541..701659) /gene="COQ2" /locus_tag="YNR041C" /EC_number="2.5.1.39" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:10469659|PMID:1740455|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:359053]" /experiment="EXISTENCE:genetic interaction:GO:0006744 ubiquinone biosynthetic process [PMID:15548532]" /experiment="EXISTENCE:genetic interaction:GO:0008412 4-hydroxybenzoate polyprenyltransferase activity [PMID:7765507]" /experiment="EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:1740455]" /experiment="EXISTENCE:mutant phenotype:GO:0008412 4-hydroxybenzoate polyprenyltransferase activity [PMID:1740455]" /note="Para hydroxybenzoate polyprenyl transferase; catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis; human COQ2, mutations in which are implicated in an increased risk of mutiple-system atrophy, can complement a yeast coq2 null mutant" /codon_start=1 /product="4-hydroxybenzoate octaprenyltransferase" /protein_id="DAA10583.1" /db_xref="SGD:S000005324" /translation="MFIWQRKSILLGRSILGSGRVTVAGIIGSSRKRYTSSSSSSSSP SSKESAPVFTSKELEVARKERLDGLGPFVSRLPKKWIPYAELMRLEKPVGTWLLYLPC SWSILMGAMMQGATLSATAGMLGIFGVGALVMRGAGCTINDFLDRKLDQRVIRSVERP IASGRVSPRRALVFLGAQTLVGMGVLSLLPAQCWWLGLASLPIVFTYPLFKRFTYYPQ AALSACFNWGALLGFPAMGVMSWPTMIPLYLSSYLWCMTYDTIYAHQDKKFDIKAGIK STALAWGPRTKSIMKAMSASQIALLAVAGLNSGLLWGPGFIGGLGVFAYRLFSMIKKV DLDNPKNCWKYFNANINTGLYFTYALAVDYILRLFGFL" gene 701895..703085 /gene="MVD1" /locus_tag="YNR043W" /gene_synonym="ERG19" mRNA 701895..703085 /gene="MVD1" /locus_tag="YNR043W" /gene_synonym="ERG19" /product="diphosphomevalonate decarboxylase MVD1" CDS 701895..703085 /gene="MVD1" /locus_tag="YNR043W" /gene_synonym="ERG19" /EC_number="4.1.1.33" /experiment="EXISTENCE:direct assay:GO:0004163 diphosphomevalonate decarboxylase activity [PMID:8626466|PMID:15169949]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:8626466]" /experiment="EXISTENCE:mutant phenotype:GO:0004163 diphosphomevalonate decarboxylase activity [PMID:15169949|PMID:1779710]" /experiment="EXISTENCE:mutant phenotype:GO:0016126 sterol biosynthetic process [PMID:9244250]" /note="Mevalonate pyrophosphate decarboxylase; essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer" /codon_start=1 /product="diphosphomevalonate decarboxylase MVD1" /protein_id="DAA10584.1" /db_xref="SGD:S000005326" /translation="MTVYTASVTAPVNIATLKYWGKRDTKLNLPTNSSISVTLSQDDL RTLTSAATAPEFERDTLWLNGEPHSIDNERTQNCLRDLRQLRKEMESKDASLPTLSQW KLHIVSENNFPTAAGLASSAAGFAALVSAIAKLYQLPQSTSEISRIARKGSGSACRSL FGGYVAWEMGKAEDGHDSMAVQIADSSDWPQMKACVLVVSDIKKDVSSTQGMQLTVAT SELFKERIEHVVPKRFEVMRKAIVEKDFATFAKETMMDSNSFHATCLDSFPPIFYMND TSKRIISWCHTINQFYGETIVAYTFDAGPNAVLYYLAENESKLFAFIYKLFGSVPGWD KKFTTEQLEAFNHQFESSNFTARELDLELQKDVARVILTQVGSGPQETNESLIDAKTG LPKE" gene 703699..705876 /gene="AGA1" /locus_tag="YNR044W" mRNA 703699..705876 /gene="AGA1" /locus_tag="YNR044W" /product="Aga1p" CDS 703699..705876 /gene="AGA1" /locus_tag="YNR044W" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:2072914|PMID:7957044]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000752 agglutination involved in conjugation with cellular fusion [PMID:7957044|PMID:2072914]" /experiment="EXISTENCE:mutant phenotype:GO:0050839 cell adhesion molecule binding [PMID:7957044|PMID:2072914]" /note="Anchorage subunit of a-agglutinin of a-cells; highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds; AGA1 has a paralog, FIG2, that arose from the whole genome duplication" /codon_start=1 /product="Aga1p" /protein_id="DAA10585.1" /db_xref="SGD:S000005327" /translation="MTLSFAHFTYLFTILLGLTNIALASDPETILVTITKTNDANGVV TTTVSPALVSTSTIVQAGTTTLYTTWCPLTVSTSSAAEISPSISYATTLSRFSTLTLS TEVCSHEACPSSSTLPTTTLSVTSKFTSYICPTCHTTAISSLSEVGTTTVVSSSAIEP SSASIISPVTSTLSSTTSSNPTTTSLSSTSTSPSSTSTSPSSTSTSSSSTSTSSSSTS TSSSSTSTSPSSTSTSSSLTSTSSSSTSTSQSSTSTSSSSTSTSPSSTSTSSSSTSTS PSSKSTSASSTSTSSYSTSTSPSLTSSSPTLASTSPSSTSISSTFTDSTSSLGSSIAS SSTSVSLYSPSTPVYSVPSTSSNVATPSMTSSTVETTVSSQSSSEYITKSSISTTIPS FSMSTYFTTVSGVTTMYTTWCPYSSESETSTLTSMHETVTTDATVCTHESCMPSQTTS LITSSIKMSTKNVATSVSTSTVESSYACSTCAETSHSYSSVQTASSSSVTQQTTSTKS WVSSMTTSDEDFNKHATGKYHVTSSGTSTISTSVSEATSTSSIDSESQEQSSHLLSTS VLSSSSLSATLSSDSTILLFSSVSSLSVEQSPVTTLQISSTSEILQPTSSTAIATISA STSSLSATSISTPSTSVESTIESSSLTPTVSSIFLSSSSAPSSLQTSVTTTEVSTTSI SIQYQTSSMVTISQYMGSGSQTRLPLGKLVFAIMAVACNVIFS" gene 706139..707608 /gene="PET494" /locus_tag="YNR045W" mRNA 706139..707608 /gene="PET494" /locus_tag="YNR045W" /product="Pet494p" CDS 706139..707608 /gene="PET494" /locus_tag="YNR045W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:8389363]" /experiment="EXISTENCE:mutant phenotype:GO:0045182 translation regulator activity [PMID:2833749]" /experiment="EXISTENCE:mutant phenotype:GO:0070131 positive regulation of mitochondrial translation [PMID:2833749]" /note="Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane" /codon_start=1 /product="Pet494p" /protein_id="DAA10586.1" /db_xref="SGD:S000005328" /translation="MHLKKGKRSISTVWRLLWKRFYSVNSKTNMHFSRSRKKPVTNFT RTNGLLLSCNGDTFPYLRTLWRYFNAPGNLMFVTTNIVAFMGIVTYNTLVTISSERAF EEQMMAAQVSLAKQREELETTALSLPRDIELRGEEDDIKWEQPDVAHVREDPLVEEQN AKLDTPIKQYTLGDLILNKRENVTDYDSQRAKASIFHMLYAYMLYRDVIQPTTMTQNN NSEEWRREVELLTKGKEVQGTHRRIDVFYDLWNKNFDKIVTSPEKVQNFQLPNWSKYP TILKFICTELHDNSLKTLGEFKQFYGKVRSNEVKKLLGLWLYDHSFLFPHNIYDNRTE EDFYDILINDSMQDNRIFQKYSSIVMNPYNERTQLFFPNVNSPSVNKPVPSISLETYT RLLKGYINLQETGCKYDYNDNIFKLISILKLNCFLQRNKKKHAGPTVRILLPRDEDRS QILGTISQAEKRTCYQILSKNRDVVALLKRISDIQADSS" gene 707788..708195 /gene="TRM112" /locus_tag="YNR046W" mRNA 707788..708195 /gene="TRM112" /locus_tag="YNR046W" /product="RNA methylation protein TRM112" CDS 707788..708195 /gene="TRM112" /locus_tag="YNR046W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591|PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14690591|PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0008276 protein methyltransferase activity [PMID:17008308]" /experiment="EXISTENCE:direct assay:GO:0018364 peptidyl-glutamine methylation [PMID:17008308]" /experiment="EXISTENCE:direct assay:GO:0160102 tRNA (guanine(10)-N2)-methyltransferase activity [PMID:15899842]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:22956767]" /experiment="EXISTENCE:mutant phenotype:GO:0016435 rRNA (guanine) methyltransferase activity [PMID:22493060]" /experiment="EXISTENCE:mutant phenotype:GO:0030488 tRNA methylation [PMID:15899842]" /experiment="EXISTENCE:mutant phenotype:GO:0030490 maturation of SSU-rRNA [PMID:22956767]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:22956767]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:22956767]" /experiment="EXISTENCE:mutant phenotype:GO:0070476 rRNA (guanine-N7)-methylation [PMID:22493060]" /experiment="EXISTENCE:mutant phenotype:GO:0160102 tRNA (guanine(10)-N2)-methyltransferase activity [PMID:15899842]" /experiment="EXISTENCE:physical interaction:GO:0035657 eRF1 methyltransferase complex [PMID:17008308]" /experiment="EXISTENCE:physical interaction:GO:0043528 tRNA (m2G10) methyltransferase complex [PMID:15899842]" /note="Protein involved in methylation of tRNA, rRNA, and translation factors; also involved in ribosome biogenesis; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; N7-methylates G1575 of 18S rRNA as complex with Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; relative distribution to the nucleus increases upon DNA replication stress; functional homolog of human TRMT112" /codon_start=1 /product="RNA methylation protein TRM112" /protein_id="DAA10587.1" /db_xref="SGD:S000005329" /translation="MKFLTTNFLKCSVKACDTSNDNFPLQYDGSKCQLVQDESIEFNP EFLLNIVDRVDWPAVLTVAAELGNNALPPTKPSFPSSIQELTDDDMAILNDLHTLLLQ TSIAEGEMKCRNCGHIYYIKNGIPNLLLPPHLV" gene 708523..711204 /gene="FPK1" /locus_tag="YNR047W" mRNA 708523..711204 /gene="FPK1" /locus_tag="YNR047W" /product="serine/threonine protein kinase FPK1" CDS 708523..711204 /gene="FPK1" /locus_tag="YNR047W" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:18199685]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:29895620|PMID:19966303|PMID:28069741]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18199685|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19966303]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:25378585]" /experiment="EXISTENCE:genetic interaction:GO:0001932 regulation of protein phosphorylation [PMID:28069741]" /experiment="EXISTENCE:genetic interaction:GO:0004674 protein serine/threonine kinase activity [PMID:19966303]" /experiment="EXISTENCE:genetic interaction:GO:0061092 positive regulation of phospholipid translocation [PMID:18199685]" /experiment="EXISTENCE:mutant phenotype:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:11337509]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:19966303]" /experiment="EXISTENCE:mutant phenotype:GO:2000370 positive regulation of clathrin-dependent endocytosis [PMID:28069741]" /note="Ser/Thr protein kinase; phosphorylates several aminophospholipid translocase family members, regulating phospholipid translocation and membrane asymmetry; phosphorylates and inhibits the protein kinase Akl1p, stimulating endocytosis; phosphorylates and inhibits upstream inhibitory kinase Ypk1p; localizes to the cytoplasm, early endosome/TGN, the plasma membrane and the shmoo tip; redundant role with KIN82 in the mating pheromone response; activity stimulated by Gin4p kinase and sphingolipid MIPC" /codon_start=1 /product="serine/threonine protein kinase FPK1" /protein_id="DAA10588.1" /db_xref="SGD:S000005330" /translation="MAGHHHEHEQERDHEQEHEHDSLQRPTTGSERTRSISFSKLLTR SWKRNASSSNNMSVSSVNLYSDPENSRESDHNNSGSEGQSSRFSKLKSMFQSGNSSKN ASAHNSSQSSLEGDSASSSSKLRYVKPMTSVANASPASPPLSPTIPETDVLQTPKMVH IDQHEHEREHSNCGSPIMLSSSSFSPTVARTGTGRRRSPSTPIMPSQNSNNSSSTSAI RPNNYRHHSGSQGFSSNNPFRERAGTVRSSNPYFAYQGLPTHAMSSHDLDEGFQPYAN GSGIHFLSTPTSKTNSLTNTKNLSNLSLNEIKENEEVQEFNNEDFFFHDIPKDLSLKD TLNGSPSRGSSKSPTITQTFPSIIVGFDNEYEEDNNNDKHDEKEEQQTTTDNKTRNLS PTKQNGKATHPRIKIPLRRAASEPNGLQLASATSPTSSSARKTSGSSNINDKIPGQSV PPPNSFFPQEPSPKISDFPEPRRSRRLRTKSFSNKFQDIMVGPQSFEKIRLLGQGDVG KVFLVREKKTNRVYALKVLSKDEMIKRNKIKRVLTEQEILATSNHPFIVTLYHSFQSE DYLYLCMEYCMGGEFFRALQTRKTKCICEDDARFYASEVTAALEYLHLLGFIYRDLKP ENILLHQSGHIMLSDFDLSIQAKDSKVPVVKGSAQSTLVDTKICSDGFRTNSFVGTEE YIAPEVIRGNGHTAAVDWWTLGILIYEMLFGFTPFKGDNTNETFTNILKNEVSFPNNN EISRTCKDLIKKLLTKNESKRLGCKMGAADVKKHPFFKKVQWSLLRNQEPPLIPVLSE DGYDFAKLSSNKKRQTSQDSHKHLDEQEKNMFEERVEYDDEVSEDDPFHDFNSMSLME QDNNSMIYGNTNSYGKIAYTPNSNRSRSNSHRTFFKR" gene 711630..712811 /locus_tag="YNR048W" /gene_synonym="CRF1" mRNA 711630..712811 /locus_tag="YNR048W" /gene_synonym="CRF1" /product="putative aminophospholipid translocase regulatory protein" CDS 711630..712811 /locus_tag="YNR048W" /gene_synonym="CRF1" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0045332 phospholipid translocation [PMID:12842877]" /experiment="EXISTENCE:physical interaction:GO:0005802 trans-Golgi network [PMID:17093059]" /note="Potential noncatalytic subunit for phospholipid translocase Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication" /codon_start=1 /product="putative aminophospholipid translocase regulatory protein" /protein_id="DAA10589.1" /db_xref="SGD:S000005331" /translation="MGLILRWKEKKQLSSKQNAQKSRKPANTSFRQQRLKAWQPILSP QSVLPLLILMACVFAPIGIGLVVSTISVQRLVVNYTECDALAPAKHFETIPSEYVDYH FSKKVAVQPQWMVLTDPELGNQTCRIQFEVPNHIKKSTYVYYRLTNFNQNYREYVQSL DLDQLKGKALIGNDLDPNCDPLRTVENKTIFPCGLIANSMFNDTFGTTLTGVNDTADY LLTTKGIAWDTDSHRYGKTEYNASDIVPPPNWAKLFPNGYTDDNIPDLQNWEQFKIWM RTAALPNFYKLAMKNETNGLGKGIYIADIELNYPVRSFYGTKSFVLTTNSIIGAGNEA LGIVYLIVAGIATLFAILFLIKVIFKPRPMHDHSYLNFENSDTPFDESSVVSIPLREI L" gene complement(713023..713655) /gene="MSO1" /locus_tag="YNR049C" mRNA complement(713023..713655) /gene="MSO1" /locus_tag="YNR049C" /product="Mso1p" CDS complement(713023..713655) /gene="MSO1" /locus_tag="YNR049C" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:16030256|PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16030256|PMID:16087665]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:16030256|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:22842922|PMID:16030256]" /experiment="EXISTENCE:direct assay:GO:0006904 vesicle docking involved in exocytosis [PMID:9207091]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:16087665]" /experiment="EXISTENCE:direct assay:GO:0033101 cellular bud membrane [PMID:16087665]" /experiment="EXISTENCE:mutant phenotype:GO:0006904 vesicle docking involved in exocytosis [PMID:9207091]" /experiment="EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:16030256]" /experiment="EXISTENCE:mutant phenotype:GO:0061025 membrane fusion [PMID:16030256]" /note="Lipid-interacting protein in SNARE complex assembly machinery; acts at late step in secretion; interacts with membranes through two distinct binding sites; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; N-terminus closely associates with plasma membrane, C-terminus colocalizes with Sec4p on intracellular membranes; relocalizes from bud neck to nucleus upon DNA replication stress" /codon_start=1 /product="Mso1p" /protein_id="DAA10590.1" /db_xref="SGD:S000005332" /translation="MMSQVSHSQEGSGRFWNKFKSSTKSLSTSLAHLSIKAEKDGDTV NTTLVHKGLVKFYENQHPFQGFPGWLGEKEDLPNERKILDTQVKHDMKKQNSRHFSPS FSNRRKASSEDPMGTPSSNGNTPEYTPASKSFQDIYNNHTSSSSATPRRASSRPTRPS AGQEFRASLGRSKTSNSFNTSSTPTPPPDASSGVMAMKDRLKRRNNDYGF" gene complement(714048..715388) /gene="LYS9" /locus_tag="YNR050C" /gene_synonym="LYS13" mRNA complement(714048..715388) /gene="LYS9" /locus_tag="YNR050C" /gene_synonym="LYS13" /product="saccharopine dehydrogenase (NADP+, L-glutamate-forming)" CDS complement(714048..715388) /gene="LYS9" /locus_tag="YNR050C" /gene_synonym="LYS13" /EC_number="1.5.1.10" /experiment="EXISTENCE:direct assay:GO:0004755 saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity [PMID:18416559]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0019878 lysine biosynthetic process via aminoadipic acid [PMID:6429126]" /note="Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112" /codon_start=1 /product="saccharopine dehydrogenase (NADP+, L-glutamate-forming)" /protein_id="DAA10591.1" /db_xref="SGD:S000005333" /translation="MGKNVLLLGSGFVAQPVIDTLAANDDINVTVACRTLANAQALAK PSGSKAISLDVTDDSALDKVLADNDVVISLIPYTFHPNVVKSAIRTKTDVVTSSYISP ALRELEPEIVKAGITVMNEIGLDPGIDHLYAVKTIDEVHRAGGKLKSFLSYCGGLPAP EDSDNPLGYKFSWSSRGVLLALRNSAKYWKDGKIETVSSEDLMATAKPYFIYPGYAFV CYPNRDSTLFKDLYHIPEAETVIRGTLRYQGFPEFVKALVDMGMLKDDANEIFSKPIA WNEALKQYLGAKSTSKEDLIASIDSKATWKDDEDRERILSGFAWLGLFSDAKITPRGN ALDTLCARLEELMQYEDNERDMVVLQHKFGIEWADGTTETRTSTLVDYGKVGGYSSMA ATVGYPVAIATKFVLDGTIKGPGLLAPYSPEINDPIMKELKDKYGIYLKEKTVA" gene 716120..716284 /gene="SNR49" /locus_tag="YNCN0018W" ncRNA 716120..716284 /ncRNA_class="snoRNA" /gene="SNR49" /locus_tag="YNCN0018W" /product="SNR49" /experiment="EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:15306656]" /experiment="EXISTENCE:mutant phenotype:GO:0000454 snoRNA guided rRNA pseudouridine synthesis [PMID:15306656|PMID:15923376]" /experiment="EXISTENCE:mutant phenotype:GO:0030559 rRNA pseudouridylation guide activity [PMID:15923376|PMID:15306656]" /experiment="EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:15923376]" /note="H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U990 and small subunit (SSU) rRNA at positions U120, U211, and U302" /db_xref="SGD:S000007460" gene complement(716780..718327) /gene="BRE5" /locus_tag="YNR051C" mRNA complement(716780..718327) /gene="BRE5" /locus_tag="YNR051C" /product="Bre5p" CDS complement(716780..718327) /gene="BRE5" /locus_tag="YNR051C" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0045053 protein retention in Golgi apparatus [PMID:32673164]" /experiment="EXISTENCE:mutant phenotype:GO:0016579 protein deubiquitination [PMID:12778054]" /experiment="EXISTENCE:mutant phenotype:GO:0034517 ribophagy [PMID:18391941]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:32673164]" /experiment="EXISTENCE:mutant phenotype:GO:0060628 regulation of ER to Golgi vesicle-mediated transport [PMID:12778054]" /experiment="EXISTENCE:mutant phenotype:GO:2000156 regulation of retrograde vesicle-mediated transport, Golgi to ER [PMID:14593109]" /experiment="EXISTENCE:physical interaction:GO:1990861 Ubp3-Bre5 deubiquitination complex [PMID:12778054]" /note="Ubiquitin protease cofactor; forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the ER and Golgi compartments, deubiquitinating COPII and COPI vesicle coat constituents, Sec23p and Sec27p; involved along with Ubp3p in the steady-state retention of Golgi membrane proteins, such as glycosyltransferases; null is sensitive to brefeldin A" /codon_start=1 /product="Bre5p" /protein_id="DAA10592.1" /db_xref="SGD:S000005334" /translation="MGVTVQDICFAFLQNYYERMRTDPSKLAYFYASTAELTHTNYQS KSTNEKDDVLPTVKVTGRENINKFFSRNDAKVRSLKLKLDTIDFQYTGHLHKSILIMA TGEMFWTGTPVYKFCQTFILLPSSNGSTFDITNDIIRFISNSFKPYVLTDASLSQSNE ENSVSAVEEDKIRHESGVEKEKEKEKSPEISKPKAKKETVKDTTAPTESSTQEKPIVD HSQPRAIPVTKESKIHTETVPSSTKGNHKQDEVSTEELGNVTKLNEKSHKAEKKAAPI KTKEGSVEAINAVNNSSLPNGKEVSDEKPVPGGVKEAETEIKPIEPQVSDAKESGNNA STPSSSPEPVANPPKMTWASKLMNENSDRISKNNTTVEYIRPETLPKKPTERKFEMGN RRDNASANSKNKKKPVFSTVNKDGFYPIYIRGTNGLREEKLRSALEKEFGKVMRITAA DNFAVVDFETQKSQIDALEKKKKSIDGIEVCLERKTVKKPTSNNPPGIFTNGTRSHRK QPLKRKD" gene complement(719346..720647) /gene="POP2" /locus_tag="YNR052C" /gene_synonym="CAF1" mRNA complement(719346..720647) /gene="POP2" /locus_tag="YNR052C" /gene_synonym="CAF1" /product="CCR4-NOT core DEDD family RNase subunit POP2" CDS complement(719346..720647) /gene="POP2" /locus_tag="YNR052C" /gene_synonym="CAF1" /EC_number="3.1.13.4" /experiment="EXISTENCE:direct assay:GO:0000175 3'-5'-RNA exonuclease activity [PMID:11410650]" /experiment="EXISTENCE:direct assay:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:11410650|PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:18611963]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0030015 CCR4-NOT core complex [PMID:10490603]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:21406554]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:mutant phenotype:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:11410650]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:11404327]" /note="Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation; exonuclease of the DEDD superfamily" /codon_start=1 /product="CCR4-NOT core DEDD family RNase subunit POP2" /protein_id="DAA10593.1" /db_xref="SGD:S000005335" /translation="MQSMNVQPRVLAVGGEQFFSQRQASEQHQQQNMGPQVYSPKVNR ARMFPQGMPVNTINGSVNQEMNNAYLLKQKNEPLLTQQQQQQQQQQQPFNIGTPVSVA SLPPGLNVLQQQQQQQQQQQQQQQGVGLNRPLASQLPKHLTNQSMPPIFLPPPNYLFV RDVWKSNLYSEFAVIRQLVSQYNHVSISTEFVGTLARPIGTFRSKVDYHYQTMRANVD FLNPIQLGLSLSDANGNKPDNGPSTWQFNFEFDPKKEIMSTESLELLRKSGINFEKHE NLGIDVFEFSQLLMDSGLMMDDSVTWITYHAAYDLGFLINILMNDSMPNNKEDFEWWV HQYMPNFYDLNLVYKIIQEFKNPQLQQSSQQQQQQQYSLTTLADELGLPRFSIFTTTG GQSLLMLLSFCQLSKLSMHKFPNGTDFAKYQGVIYGIDGDQ" gene complement(721120..723112) /gene="NOG2" /locus_tag="YNR053C" /gene_synonym="NUG2" mRNA complement(join(721120..721770,722303..723112)) /gene="NOG2" /locus_tag="YNR053C" /gene_synonym="NUG2" /product="putative GTPase NOG2" CDS complement(join(721120..721770,722303..723112)) /gene="NOG2" /locus_tag="YNR053C" /gene_synonym="NUG2" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:11707418]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11707418]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23212245|PMID:17443350|PMID:22735702]" /experiment="EXISTENCE:direct assay:GO:0070180 large ribosomal subunit rRNA binding [PMID:24240281]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11707418|PMID:11583615]" /experiment="EXISTENCE:mutant phenotype:GO:2000200 regulation of ribosomal subunit export from nucleus [PMID:24240281]" /note="Putative GTPase; associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; recruited by ribosomal proteins L17, L35, and L37 to assembling ribosomes after 27SB pre-rRNA is generated, immediately preceding removal of ITS2" /codon_start=1 /product="putative GTPase NOG2" /protein_id="DAA10594.1" /db_xref="SGD:S000005336" /translation="MGTGKKEKSRRIREGDTKDGNLRVKGENFYRDSKRVKFLNMYTS GKEIRNKKGNLIRAASFQDSTIPDARVQPDRRWFGNTRVISQDALQHFRSALGETQKD TYQVLLRRNKLPMSLLEEKDADESPKARILDTESYADAFGPKAQRKRPRLAASNLEDL VKATNEDITKYEEKQVLDATLGLMGNQEDKENGWTSAAKEAIFSKGQSKRIWNELYKV IDSSDVVIHVLDARDPLGTRCKSVEEYMKKETPHKHLIYVLNKCDLVPTWVAAAWVKH LSKERPTLAFHASITNSFGKGSLIQLLRQFSQLHTDRKQISVGFIGYPNTGKSSIINT LRKKKVCQVAPIPGETKVWQYITLMKRIFLIDCPGIVPPSSKDSEEDILFRGVVRVEH VTHPEQYIPGVLKRCQVKHLERTYEISGWKDATEFIEILARKQGRLLKGGEPDESGVS KQILNDFNRGKIPWFVLPPEKEGEEKPKKKEVEKTA" gene complement(721938..722211) /gene="SNR191" /locus_tag="YNCN0019C" ncRNA complement(721938..722211) /ncRNA_class="snoRNA" /gene="SNR191" /locus_tag="YNCN0019C" /product="SNR191" /experiment="EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:12810910]" /experiment="EXISTENCE:mutant phenotype:GO:0030559 rRNA pseudouridylation guide activity [PMID:12810910]" /experiment="EXISTENCE:mutant phenotype:GO:0031118 rRNA pseudouridine synthesis [PMID:12810910]" /experiment="EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:15923376|PMID:12810910]" /note="H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at positions U2258 and U2260; encoded within the intron of NOG2/YNR053C" /db_xref="SGD:S000029463" gene complement(723356..724306) /gene="ESF2" /locus_tag="YNR054C" /gene_synonym="ABT1" mRNA complement(723356..724306) /gene="ESF2" /locus_tag="YNR054C" /gene_synonym="ABT1" /product="RNA-binding ATPase activator ESF2" CDS complement(723356..724306) /gene="ESF2" /locus_tag="YNR054C" /gene_synonym="ABT1" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:16772403]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:16772403]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095|PMID:15964808]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15964808]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15964808]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15964808]" /experiment="EXISTENCE:mutant phenotype:GO:0034462 small-subunit processome assembly [PMID:15964808]" /note="Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome" /codon_start=1 /product="RNA-binding ATPase activator ESF2" /protein_id="DAA10595.1" /db_xref="SGD:S000005337" /translation="MSEKVNSDFEDFSSDEETDQHNVLIQTKKKISSKDDIFSKKVED IESENESDIEEEQKQEEKEDVEQPDKENGEKLDREVEEQASSTTSLDLKTEKLRQLVK SKAAKKSKHKTGVVYFSSIPPYMKPAKMRQILTRFGEVDRLFLKKEDDQKYKQRVKGG GNKKNKYEEGWAEFIRKRDAKLCAETLNGNIIGGKKGTFYHDDILNVKYLPGFKWADL TEQIARENDIRQAKLEMEISQANKLNAEFIRNVEQSKMIQNIKNSRKRAGKEGESADS HPHREFKQRRVETSRANAPSDIKQQSSGSKDLGNVLTNLL" gene complement(726134..726217) /locus_tag="YNCN0020C" tRNA complement(726134..726217) /locus_tag="YNCN0020C" /product="tRNA-Leu" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /experiment="EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]" /experiment="EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]" /note="Leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006653" repeat_region 726234..726574 /note="Ty3 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007147" repeat_region complement(726614..726945) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007144" repeat_region complement(727363..727661) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007145" gene complement(728426..730186) /gene="HOL1" /locus_tag="YNR055C" mRNA complement(728426..730186) /gene="HOL1" /locus_tag="YNR055C" /product="Hol1p" CDS complement(728426..730186) /gene="HOL1" /locus_tag="YNR055C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006812 monoatomic cation transport [PMID:8955402]" /experiment="EXISTENCE:mutant phenotype:GO:0015203 polyamine transmembrane transporter activity [PMID:34375581]" /experiment="EXISTENCE:mutant phenotype:GO:0015665 alcohol transmembrane transporter activity [PMID:2405251]" /experiment="EXISTENCE:mutant phenotype:GO:0015850 organic hydroxy compound transport [PMID:2405251]" /experiment="EXISTENCE:mutant phenotype:GO:0022890 inorganic cation transmembrane transporter activity [PMID:8955402]" /experiment="EXISTENCE:mutant phenotype:GO:1902047 polyamine transmembrane transport [PMID:34375581]" /note="Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake" /codon_start=1 /product="Hol1p" /protein_id="DAA10596.1" /db_xref="SGD:S000005338" /translation="MDKYTNRDHPDYIPGTFNIYSSQNLENGIIYESKLKKTSSGVVL IPQPSYSPNDPLNWSSWRKLAHFGLMAFITAFTAATSNDAGAAQDSLNEIYGISYDSM NTGAGVLFLGIGWSTLFLAPFANLYGRKITYIVCTTLGLFGALWFALAKRTSDTIWSQ LFVGISESCAEAQVQLSLSDIFFQHQLGSVLTVYIMCTSIGTFLGPLIAGYISAFTNF RWVGWVAVIISGGLLITIIFGCEETYFDRGQYMTPLTSCQSGYEDGTTLQNSDNTAVS RRKRHLDAKLSTPGAMGEKGVDLSETAEFEVNNEEEVTIPETRELIDGSKEHLKPYPK RVAILTKATNLKGYGFKQYFKYLKINLRMFLFPPVWLSGMFWGIQDVFLTFYLTTQES AYYEPPWNYSDFGVAIMNVPTLIGAVIGCICAGIVSDYFVLWMARHNRGILEAEFRLY FSIATAIIGPAGLLMFGIGTARQWPWQAIYVGLGFVGFAWGCSGDIAMAYLMDCYPDM VLEGMVCTAIINNTISCIFTFTCSDWLAASGTENTYIALAVINFGITAFALPMYYYGK RIRLWTKRWYLQSVNLRDGV" regulatory complement(730381..730401) /regulatory_class="other" /note="Upstream open reading frame (uORF) in 5' untranslated region of HOL1 gene, regulate translation" gene complement(731618..733303) /gene="BIO5" /locus_tag="YNR056C" mRNA complement(731618..733303) /gene="BIO5" /locus_tag="YNR056C" /product="Bio5p" CDS complement(731618..733303) /gene="BIO5" /locus_tag="YNR056C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0022857 transmembrane transporter activity [PMID:10333520]" /experiment="EXISTENCE:direct assay:GO:0051180 vitamin transport [PMID:10333520]" /experiment="EXISTENCE:mutant phenotype:GO:0009102 biotin biosynthetic process [PMID:10333520]" /experiment="EXISTENCE:mutant phenotype:GO:0051180 vitamin transport [PMID:10333520]" /note="Putative transmembrane protein involved in the biotin biosynthesis; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis" /codon_start=1 /product="Bio5p" /protein_id="DAA10597.1" /db_xref="SGD:S000005339" /translation="MNRVGAVFLFVYERNFFLSIVPDRHRTEIRMSSSERSEVKFDKH FNWWSLLGIAFSLSCSWVGISASMAVGIASGGPLLIIYGLIIAAFFSLMCGISLGDFA AILPNSSGGSFWVLKMLEQESVTLKTPEYEDPSDDDEEVFLENYCQTFNVEVSSKFQK VSSMVVGLLNYFGAIFTTASICSSLSMSCIGIHKLLHPDYELKHWHVFVGYECINAVL TLFNIYSTPLPYISQFGLYTSLLSFAMTFIICIVSRSDNTVDPWPKASNIFGSFDNQT GWNSSGMAFVVGLVNPIWAFVGIDSATHMIDEVGYSKSRFLVPKVIITTIIVGFVTSF IYCVGLFFCITDQTAVVESILPIVEIFYQATGNRNLSVFLQCMCITTGFVSGIASGTW QSRILQSFGKSYAPFYKEGSLGNKSLKKLAVLTPGFKSPLYAHFLSQICVTIIGCIFM GSSTAFNAIITACITLLLMSYAVPSFIFLFVIKKEKFIHRIESDVNCVSRPNRRRMSM IPHIICILWTLFCLVFLSFPYTLPVTAGNMNYTSVVYAVVFCIISIVVFPTCI" gene complement(733356..734069) /gene="BIO4" /locus_tag="YNR057C" mRNA complement(733356..734069) /gene="BIO4" /locus_tag="YNR057C" /product="dethiobiotin synthase" CDS complement(733356..734069) /gene="BIO4" /locus_tag="YNR057C" /EC_number="6.3.3.3" /experiment="EXISTENCE:direct assay:GO:0004141 dethiobiotin synthase activity [PMID:10333520]" /experiment="EXISTENCE:direct assay:GO:0009102 biotin biosynthetic process [PMID:10333520]" /experiment="EXISTENCE:mutant phenotype:GO:0009102 biotin biosynthetic process [PMID:10333520]" /note="Dethiobiotin synthetase; catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria; expression appears to be repressed at low iron levels" /codon_start=1 /product="dethiobiotin synthase" /protein_id="DAA10598.1" /db_xref="SGD:S000005340" /translation="MNSKSQQQEQQPIVFVTGTDTDVGKTFVSTLLVHKWKAAYWKPV QTGIESDQGDSETLKNFKIAASTWQPPIFTPTYALQKPLSPLQAMEYEPNVDIRLLDF VVPEEWSAENPLVVEGAGGVCVPITRKLEITTDLIKHLIETSGHPVYVVVVARSGLGT LNHTLLTWNHLCDNGLRSHLFGVILNGEPNEGNVQALKKFGVNIMAQVAQCTTAHDQD MELHELPSVESLMTQQDVE" gene 734291..735733 /gene="BIO3" /locus_tag="YNR058W" mRNA 734291..735733 /gene="BIO3" /locus_tag="YNR058W" /product="adenosylmethionine-8-amino-7-oxononanoate transaminase" CDS 734291..735733 /gene="BIO3" /locus_tag="YNR058W" /EC_number="2.6.1.62" /experiment="EXISTENCE:direct assay:GO:0004015 adenosylmethionine-8-amino-7-oxononanoate transaminase activity [PMID:10333520]" /experiment="EXISTENCE:direct assay:GO:0009102 biotin biosynthetic process [PMID:10333520]" /experiment="EXISTENCE:mutant phenotype:GO:0009102 biotin biosynthetic process [PMID:10333520]" /note="7,8-diamino-pelargonic acid aminotransferase (DAPA); catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria" /codon_start=1 /product="adenosylmethionine-8-amino-7-oxononanoate transaminase" /protein_id="DAA10599.1" /db_xref="SGD:S000005341" /translation="MSQEISYTPDVAELLDFDKKHIWHPYTSLSSPLNVYPVKSAHGC KLVLDTDSPVDVEVIDAMSSWWCVIHGYNNPELNEALTKQMLKFSHVLLGGFTHKGAV NLVQKLLKVIDEPSLQYCFLADSGSVAVEVALKMALQSNMSGEATKNRTKFLTIKNGY HGDTFGAMSVCDPENSMHHIYNDRLSENIFAQAPSIVDGLPTSQNGFEDHWNAEEVTD LKKQFELHSDKICAVILEPILQGAGGLRPYHPQFLIEVQKLCNQYDVLFIMDEIATGF GRTGEIFAFKHCQKYQDQHGISPSDQIKVVPDILCVGKGLTSGYMTMSAVVVNDKVAS RISSPNSPTGGCFMHGPTFMGNALACSVAEKSMDILLRGEWRKQVSAIENQIYRELYQ YIKNPDNGLIGTVVKRVSVIGAVGIVELYKKTDPEWFQKKFISKGVHIRPFNCLCYIM PPYVITTEELTKVNQVLIEVLHEWKSHINQ" gene 736803..738545 /gene="MNT4" /locus_tag="YNR059W" mRNA 736803..738545 /gene="MNT4" /locus_tag="YNR059W" /product="putative alpha-1,3-mannosyltransferase" CDS 736803..738545 /gene="MNT4" /locus_tag="YNR059W" /experiment="EXISTENCE:curator inference:GO:0006493 protein O-linked glycosylation [PMID:10521541]" /note="Putative alpha-1,3-mannosyltransferase; not required for protein O-glycosylation; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively" /codon_start=1 /product="putative alpha-1,3-mannosyltransferase" /protein_id="DAA10600.1" /db_xref="SGD:S000005342" /translation="MVLRIRRIKKLAPLIFTSLLSLIVLFRVYRQYPFSDHFETRRED DRSGNVHCFSRLRQIEEYEKPELTSKFYEPNRWKSFISYVTRSRKDVKTVSRSLSNLD LYQKCSKEIRADQDISLLHSIETKLFPYINFTALNSEQSHNFWPVHTRFDGTKYRGQV LQFSSENNSFIGTSPIEFKASEPFWENWLNSALQRNSKGVVMSVSEYLVADTIRLIRV LRLLNNSLPIEIVHKSDLHESSQQLLIAAARESGSLNYPPQELWFLDVKDMLNDEYLA RFKRFSNKWLAITFCSFQIPIFLDSDTVPFVPLDTLYEIDGFKRTGTLFFKDRSFPTS KLSPLQVKVLKQIINNSLDVSSDSEQGFEILKHNLNDEMAIDAIEALIFKKQKHYMDS GLVIFDKQKHFFCLPIAIMLQFSPIQEFFHGDKEWFWLSLFISKKEFTFYPIEASNVG RLEKPETLESSTICSTQLSHTDVYGNLLWLNGGLSVCKKNCWNYDFTKRKEIAAKYKS VDELRNYYQSPVKLEAVIIPDVSKSPWSQQSECVMYSYCTHYRKGQYGKLIEFTDSQK KYYEKVVELWNKVV" gene 739951..742110 /gene="FRE4" /locus_tag="YNR060W" mRNA 739951..742110 /gene="FRE4" /locus_tag="YNR060W" /product="ferric-chelate reductase" CDS 739951..742110 /gene="FRE4" /locus_tag="YNR060W" /EC_number="1.16.1.9" /experiment="EXISTENCE:genetic interaction:GO:0000293 ferric-chelate reductase activity [PMID:11120744]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:11120744]" /experiment="EXISTENCE:mutant phenotype:GO:0015891 siderophore transport [PMID:11120744]" /note="Ferric reductase; reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" /codon_start=1 /product="ferric-chelate reductase" /protein_id="DAA10601.1" /db_xref="SGD:S000005343" /translation="MLLVHIISFLLFFQLSAAKAPPSKTSLINTHERRSIYSCYVGLR KETWGFNGSAICRYEPAIQSMLYCLYEDTHEKGYSNKTLEKGFEEMRQFCYTPKFLNM TDAEFYTSLDNGTYYIQDQPKAGINITYPIRLNTTLRKAYYDAYYGYYYNHDIPYYFG GIICAYFVGVMLLAGLIRFLNYTPIKKIMFQQKLVNYVRGYTTLPTLYEKHAEPFSYL KVITGYLPTRFETLVILGYLILHTIFMAYKYQYDPYHIIFAAHRAEVAHFVAYRSGIL SFAHLPLIVLFAGRNNFLQLISGLKHTSFIVFHKWLGRMMFLDAIIHAAGFTNYYLYY KKWNTVRLRVYWKFGIATTCLAGMLIFFSIAAFRRHYYETFMALHIVFAALFLYTCWE HVTNFSGIEWIYAAIAIWGVDRIVRITRIALLGFPKADLQLVGSDLVRVTVKKPKKFW KAKPGQYVFVSFLRPLCFWQSHPFTVMDSCVNDRELVIVLKAKKGVTKLVRNFVERKG GKASMRLAIEGPYGSKSTAHRFDNVLLLAGGSGLPGPISHALELGKTTAASGKNFVQL VIAVRGLDMLNACKKELMALKGLNVQVHIYNSKQELASAEKISSNEVKNGETTAEKAP SSLSNSEKAPSESENTELPLSLNDTSISDLEFATFHVGRPNVEEILNESVNHSGSLAV VCCGPPIFVDTARNQTAKAVIRNPSRMIEYLEEYQAW" gene complement(742881..743540) /locus_tag="YNR061C" mRNA complement(742881..743540) /locus_tag="YNR061C" /product="hypothetical protein" CDS complement(742881..743540) /locus_tag="YNR061C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:23708375|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /note="hypothetical protein; relocalizes from vacuole to cytoplasm upon DNA replication stress" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10602.1" /db_xref="SGD:S000005344" /translation="MLKLTTTSVTFHVLRYFQLGLSVTNLLLASFAIITNYKVDRILR LSLAVSIISSVYFGIVRFLPVLLIFVMEIVQTVLWFTAFVTLASKFGSMSCSSMPRGI NFDYSGSCKIAKIDILPEAVLFILFLATTYASYITVLSQAKENGSSTRSVLKACVKAL RDTVDRLETSLEESEPLLDLEVQEDARTETESIEDSTDSEDNANIEQEKVIDGSIEHS S" gene complement(744360..745343) /gene="PUL3" /locus_tag="YNR062C" mRNA complement(744360..745343) /gene="PUL3" /locus_tag="YNR062C" /product="Pul3p" CDS complement(744360..745343) /gene="PUL3" /locus_tag="YNR062C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Putative pulcherrimin transporter; involved in uptake of iron-transporting siderophore, pulcherrimin" /codon_start=1 /product="Pul3p" /protein_id="DAA10603.1" /db_xref="SGD:S000005345" /translation="MSIAQDRGIVFKLLSIYRAAAGIFMALAQLIVIFFGYCDFKIKG YRIASYNAPTFASSFIILAVCLLLVVVLENPEVKVTNSENSLFSALKQFFRVERKKLI SCLILLWSMFLSSFIMSEVVYFMPLFLTLHVNWDTKFQGIAFMVASILGVTGSYFAPK LINVGCSCGRAKDGGLEESDTTGSETVEVKKKDSLYSGQVFLSIFALFVSLLGQAFMI GASEALKHKSMPPTNSGIFFSAGMSITLLGYNFLASSIPALFSMYIDPKLKVQLMPSI GAISGIGKLVAPIVLAALYGTRLGLSIAVGFGMILVAVSIPPLIWLRKKRC" gene 746943..748766 /gene="PUL4" /locus_tag="YNR063W" mRNA 746943..748766 /gene="PUL4" /locus_tag="YNR063W" /product="Pul4p" CDS 746943..748766 /gene="PUL4" /locus_tag="YNR063W" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /note="Putative zinc-cluster transcription factor; involved in utilization of iron-transporting siderophore pulcherrimin" /codon_start=1 /product="Pul4p" /protein_id="DAA10604.1" /db_xref="SGD:S000005346" /translation="MDRSKDARKRSISLACTVCRKRKLKCDGNKPCGRCIRLNTPKEC IYNIDKRKDKRKIKNGSKVFLFKNNTIDNGNNSILENKGLNEDLSSHIYEKEAPKFDS DIDISRFGTNDAVIFNNDGWDTSLPIDFDFDEFNTETTDFDDFLKLLGDNSPSKEQKS LSYSPTATGLSGVVKETESEDNAPTRSRLIDVLFENKLHSVPGISKWHLYELESQYPN LECTEGNSDEKFLLSTVLCLGSLTIRKRELLNHSNIDNRPLLPENSISKLTTDAFKYY NAAKTLVPDLLSHPTIDGFCGLVLMANFMTMMISLEHQLYLSINALQLAVALNLNNNT KCKELLESNSDGIGVILLFWNIWCSSCMLATIHGKNPFITLEQITTPLPCEISPRNKT NKLLIDFMQIRIKLATLQSKIFQRLYTSSTANEVPFVNLEREFEEVSLQITRLKGFPI FEEHLFYRSRVLMLELSCLRAQASFLLYRPYLITGESLQAVTMAKSIIHEIWSQYTKQ FPDNEKERHERLDWNFCYPLRTASLTLCISCIILLRYKQVVQFLKGTELFEYILALEI LQDLVQVLPIEQNLIDIIKYPISPVQLSGDSFVEFWGRILY" gene complement(749136..750008) /locus_tag="YNR064C" mRNA complement(749136..750008) /locus_tag="YNR064C" /product="epoxide hydrolase" CDS complement(749136..750008) /locus_tag="YNR064C" /experiment="EXISTENCE:direct assay:GO:0004301 epoxide hydrolase activity [PMID:15769598]" /experiment="EXISTENCE:direct assay:GO:0097176 epoxide metabolic process [PMID:15769598]" /note="Epoxide hydrolase; member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides" /codon_start=1 /product="epoxide hydrolase" /protein_id="DAA10605.1" /db_xref="SGD:S000005347" /translation="MSNIIARFHKIQVQDGVKVWYREAGAAGNPTILLLHGFPTSSNM FRNLIPLLAGQFHIIAPDLPGFGFTETPENYKFSFDSLCESIGYLLDTLSIEKFAMYI FDYGSPVGFRLALKFPSRITGIVTQNGNAYEEGLDDRFWGPLKEYWKSYQSDPVFVKS LIPYLEDPANVICQYHDGVPAIESVDPAAYTLDIALIQRTGQTDIQLRLFFDYQNNIK LYPAFQKFLRDSKIPVLVAWGANDTIFSVAGAEAYRKDVDNLKVVYYDTGHFALETHV VAIAEEIISMFAEN" gene complement(750350..753700) /locus_tag="YNR065C" mRNA complement(750350..753700) /locus_tag="YNR065C" /product="hypothetical protein" CDS complement(750350..753700) /locus_tag="YNR065C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10606.1" /db_xref="SGD:S000005348" /translation="MLMTGSVGDGSEFDWEDQKTFISRDGGLTWRFVHNSSGLYATGD LGNIIVYIPYDPEEDGDFQSEFYYSLDQGRTWNEYELTNAISSVHPYKLINPTPDGSG SKFIFKGTFATTDSETNSITSLKGVEYIIDFSAAFDSRTCEEEDFEDWDLADGKCVNG AKYKYRRRKQDAQCLVKKAFKDLSLDETPCNSCGESDYECSFEFVRDANGLCIPDYNL IAFSNICDKSKDKSVLVEPLQLIKGDECKTPMKIEPVDIPCDEIPEEGSSDREIVTTE NKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGGQTIKRFDTNGEKIVEVVFNPY FNSSAYLFGSKGNIFSTHDRGHSFMIAKLPEARQLGMPLDFSAKAQDTFIYYGGKNCE SILSPECHAVAYLTKDGGETFTEMLDNAIHCEFAGTLFEYPSNEEMVMCQVKKKSSET RSLVSSIDFFQGDNKIIFENIIGYLSTGGYIIVAVPHEDNELRAYVTIDGTEFAEAKF PYGQDVSKQEAFTILGSEKGSIFLHLATNLESGHDFGNLLKSNSNGTSFVTLEHAVNR NTFGYVDFEKVQGLEGIIITNIVSNREKVGENKEDEQLKTKITFNDGSDWNFLKPPKK DSEGKKFPCDSVSLDKCSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGDKLLPYEE CSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENAETDSISYSTDFGKTWKDYK FCGDKVLVKDIITVPRDSALRFLLFGEAKNMGSGSFRTYTIDFRNIFERQCEFDITGK KRADFKYSPLGSRTGCLFGHQTEFLRKTDEKCFIGNIPLSEFSRNVKNCSCTRQDFEC DYNFYKASDGTCKLVKGLSSANGADICKKEPDLIEYYDSSGYRKIPLSTCKGGLKLDA HLAPHPCPGKEKAFREKYSINTGAYALVFVTILLVIFFAAWFVYDRGIRRNGGFSRFE EIRLGDDGLIENNRTDRVVNIIVRLGLCISLITKSAFQRTKAGVARFSSKLRARFGNR KGPTYSSLLQGQFSDESDGLHEDANDLSSFTSQDSNFEIEQEDAYRPEQEHTSQIDQP ATSNIPDALPARSAIHKPDSTAVRNEDE" gene complement(753725..755035) /locus_tag="YNR066C" mRNA complement(753725..755035) /locus_tag="YNR066C" /product="hypothetical protein" CDS complement(753725..755035) /locus_tag="YNR066C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:11935221]" /note="Putative membrane-localized hypothetical protein" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10607.1" /db_xref="SGD:S000005349" /translation="MILLQVICTIWTCLFIPLLNAEEFVPKVTETLSEYSFSLESFDD SNSLIRLDNQVVWISSDSGENWEAVKEIEGHILELIVDPLHGQDRAFVSIHLSPKFYV TDDRGKSWRALTIPVSENCRLGTSCSIATHPTDKKYLIADCPCFINDNGYIQIQNETY FTNDGESFYNIEPSLKKKEDDHITSSSCNFVKSSKDSDIEGNDASILCLFSNHGYDSD RHLSAAYTQLALSTDGGKTFKKFDEFNDKIIYQYKILKSHIIVSTQDDRYNEMSPMDI WISNDASTFQKARLPAQVRHVHMYGIYEDSIGRIIIPISTIFTDEKNDQPAPSEILIS DSQGLKFLPVEWTINPHFGYIDIASPHFLEGTIIGSFHPSFDYSHNKGKYNKKIARYE TKISVDNGLTWSNLKVVDEENADSFPCDITRPERCSLQNPFYSI" gene complement(755746..759099) /gene="DSE4" /locus_tag="YNR067C" /gene_synonym="ENG1" mRNA complement(755746..759099) /gene="DSE4" /locus_tag="YNR067C" /gene_synonym="ENG1" /product="endo-1,3(4)-beta-glucanase" CDS complement(755746..759099) /gene="DSE4" /locus_tag="YNR067C" /gene_synonym="ENG1" /EC_number="3.2.1.39" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:27229769]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11935221]" /experiment="EXISTENCE:direct assay:GO:0030428 cell septum [PMID:12455695]" /experiment="EXISTENCE:genetic interaction:GO:0042973 glucan endo-1,3-beta-D-glucosidase activity [PMID:12455695]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:16328626]" /note="Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother" /codon_start=1 /product="endo-1,3(4)-beta-glucanase" /protein_id="DAA10608.1" /db_xref="SGD:S000005350" /translation="MQLYLTLLFLLSFVECSYISFISNNADEILETDLIETLSYATLT VGEPYVAQSVVVTRVSAASHSPLSVSPKNRVSASPINSQDSDSNTRTAVQLSLSLSNY ASQVSQKISAQTNNDPVTVSNIYANDNSKSKSSVHNLSSVSGVASVMPSASTMRKVTT LLSQTASTSTSTLFSSSLSISGTQLNGTLLTSVSKGTIDPLVTQMPSYSSQETKIIPS SLTSNKTIYTISVRTNAATATGEDSFIASTPASSTLFYPSNSTQDLVQTLASTTASPA YPSNRTQITLSPSVSLYSTTSPIYPSNITENGSSPSPSLSSTVSPVYPSSSTGNILLS SLFSTVDSSSSPVSSTLDTIYVSSSMQATISSSSSSRQTKTSSSSLSTSTSSTATTTE NSSTTTIVNLFNAVSTDEPPTVFDRSPNPMSLADGVSNDGPIQTNKFYTNLIVGSQES PAFVYPYSLWKYTSSSYGFAVQHTTVDQYSYGGYDSSGNAEYLVNPLGIAHVVFSASN FDSSMTMQVDEMTLSSTRVVLSESNDSSNYLEIPLVQGMGFATGIYHGSLNAKIGSSV GFNTIVSESSSNLAQGILKYRITLLNGVTWLCYVIGPDDLTSTDFSLEVSSEYEIKAS ASVDGLIIQLAVAPSETDYEVFYDQAAGMYVTNFKLQGVSDGSTATYEFSYTTQGESA SGSTMIFALPHHESSFSDIMQDYYTGIQLASTTKGVMNGYLTTSLQFSTSLNRQISWL PWSSQLGSNLLEYSKEQLQLLAEVANSELQVSISESISGLNTYYLGKVIDKYSYILLT VSEIIQDEASTKSTLENIKSAFDILLQNEQTYPLIYDTKFNGLVSSGDWGSTSTQYDF GNTYYNDHHFHYGYIIHAAAVIGYVDSKLNGTWAADNKDWVNSLVRDVANPSEKDEYF AQSRMFDWFNGHSWAAGLYENGNGKNEESSSEDYNFAYAMKLWGATIGDQSMELRGDL MISIMKDAMNDYFYYQNDNTVEPEEIIGNKVSGILFDNIIDYTTYFGTNTEYIHGIHM LPITPVSSNIRSETFVEEEWQTKIEPIIESIESGWTGILKLNQALFDPVDSYAFFSDS TFDSSTYLDNGMSRTWALAFSGGLANSIA" gene complement(760067..760885) /locus_tag="YNR068C" /gene_synonym="BUL3" mRNA complement(760067..760885) /locus_tag="YNR068C" /gene_synonym="BUL3" /product="hypothetical protein" CDS complement(760067..760885) /locus_tag="YNR068C" /gene_synonym="BUL3" /note="hypothetical protein; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10609.1" /db_xref="SGD:S000005351" /translation="MRNRQNQKNWTNLRGLLSVEEREKLENLRLELVCMQAANSIPHD PPEISSLETELICLTTNTKDCKPVRFHSDLLLKKHKYNEIKKIFKEILENIEAYRDEF TKNQTKINLLLADDARASLRNRSLDFSDLMPSSIIKDVQVLANMEANVVVMKNALKTK LVGEKSVPVASSPISSIIPRTSRNKKTSPSNYHHSVLSHRKSNEWNQVSSTEYKRTLL LNIKYNDDFKATIVPSFESCLCSRSYFLRVKLHFDKGVGSAEIDIPVQVKNSFI" gene complement(761123..762592) /gene="BSC5" /locus_tag="YNR069C" /gene_synonym="BUL3" mRNA complement(761123..762592) /gene="BSC5" /locus_tag="YNR069C" /gene_synonym="BUL3" /product="Bsc5p" CDS complement(761123..762592) /gene="BSC5" /locus_tag="YNR069C" /gene_synonym="BUL3" /note="hypothetical protein; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro" /codon_start=1 /product="Bsc5p" /protein_id="DAA10610.1" /db_xref="SGD:S000005352" /translation="MQESKEPQNKFEGCQRISSSSSTLFGGTSFEEPRCGTSQGKEED AFACNNGDHCSSITNVQEDDFVLPELLPSFEMYENLLSNIPQSSFDTYFPENPPFYEV ASRNQSIPSEGESGNDMRILTGDIVGPDNHEVTVDGRRFASGPAESQIRNYDDTKGIP VENIYALPRIKTPIATELYVTKTAPKFGQLPKHESMLREYTSGDIIHGYFTVENKSTK PIKFDMFYLTLEGTTSSKTQSPFGIQKTTERILRMVDMAASWSYNHEDVNTGEDLCGF FDSIDKTSFGLPNSRILNPGDKRKKFFTFKIPNQLLDVTCKHGHFSHSLLPPTLGFDR PSSSHPELSTLKFSESLGYGRLSERGSSLWLNDSSSGSLINYSINAMIVGKDVASGRV CLMSEKKYSIRIVPFGFQNNPISREKCLKDLEDFDIEIANRLGMIEKVFSKIERAIPI HKEDIQEANRSDQLSPLRGKYEWNAVAGNTENGTLKKKH" gene 765375..769376 /gene="PDR18" /locus_tag="YNR070W" mRNA 765375..769376 /gene="PDR18" /locus_tag="YNR070W" /product="ATP-binding cassette multidrug transporter PDR18" CDS 765375..769376 /gene="PDR18" /locus_tag="YNR070W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:21831043]" /experiment="EXISTENCE:mutant phenotype:GO:0008559 ABC-type xenobiotic transporter activity [PMID:21831043]" /experiment="EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:21831043]" /experiment="EXISTENCE:mutant phenotype:GO:0055092 sterol homeostasis [PMID:21831043]" /experiment="EXISTENCE:mutant phenotype:GO:0071466 cellular response to xenobiotic stimulus [PMID:21831043]" /note="Transporter of the ATP-binding cassette (ABC) family; role in plasma membrane sterol incorporation; implicated in pleiotropic drug resistance; provides resistance to ethanol stress and contributes to a decreased intracellular accumulation of ethanol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /codon_start=1 /product="ATP-binding cassette multidrug transporter PDR18" /protein_id="DAA10611.1" /db_xref="SGD:S000005353" /translation="MECVSVEGLDSSFLEGQTFGDILCLPWTIIKGIRERKNRNKMKI ILKNVSLLAKSGEMVLVLGRPGAGCTSFLKSAAGETSQFAGGVTTGHISYDGIPQKEM MQHYKPDVIYNGEQDVHFPHLTVKQTLDFAISCKMPAKRVNNVTKEEYITANREFYAK IFGLTHTFDTKVGNDFISGVSGGERKRVSIAEALAAKGSIYCWDNATRGLDSSTALEF ARAIRTMTNLLGTTALVTVYQASENIYETFDKVTVLYAGRQIFCGKTTEAKDYFENMG YLCPPRQSTAEYLTAITDPNGLHEIKPGFEYQVPHTADEFEKYWLDSPEYARLKGEIQ KYKHEVNTEWTKKTYNESMAQEKSKGTRKKSYYTVSYWEQIRLCTIRGFLRIYGDKSY TVINTCAAIAQAFITGSLFYQAPSSTLGAFSRSGVLFFSLLYYSLMGLANISFEHRPI LQKHKVYSLYHPSAEALASTISSFPFRMIGLTFFIIILYFLAGLHRSAGAFFTMYLLL TMCSEAITSLFQMVSSLCDTLSQANSIAGVVMLSIAMYSTYMIQLPSMHPWFKWISYI LPIRYAFESMLNAEFHGRHMDCGGTLVPSGPGFENILPENQVCAFVGSRPGQSWVLGD DYLRAQYQYEYKNTWRNFGIMWCFLIGYIVLRAVFTEYKSPVKSGGDALVVKKGTKNA IQRSWSSKNDEENLNASIATQDMKEIASSNDDSTSADFEGLESTGVFIWKNVSFTIPH SSGQRKLLDSVSGYCVPGTLTALIGESGAGKTTLLNTLAQRNVGTITGDMLVDGLPMD ASFKRRTGYVQQQDLHVAELTVKESLQFSARMRRPQSIPDAEKMEYVEKIISILEMQE FSEALVGEIGYGLNVEQRKKLSIGVELVGKPDLLLFLDEPTSGLDSQSAWAVVKMLKR LALAGQSILCTIHQPSATLFEQFDRLLLLGKGGQTIYFGEIGKNSSSVIKYFEKNGAR KCQQNENPAEYILEAIGAGATASVQQNWPDIWQKSHEYANINEKINDMIKDLSSTTLH KTATRASKYATSYSYQFHHVLKRSSLTFWRNLNYIMAKMMLLMISGLFIGFTFFHVGV NAIGLQNSLFACFMAIVISAPATNQIQERATVAKELYEVRESKSNMFHWSLLLITHYL NELPYHLLFSTIFFVSSYFPLGVFTEASRSSVFYLNYAILFQLYYIGLALMILYMSPN LQSANVIVGFILSFLLSFCGAVQPASLMPGFWTFMWKLSPYTYFLQNLVGLLMHDKPV RCSKKELSLFNPPVGQTCGEFTKPFFEFGTGYIANPDATADCAYCQYKVGDEYLARIN ASFSYLWRNFGFI" gene complement(770440..771468) /locus_tag="YNR071C" mRNA complement(770440..771468) /locus_tag="YNR071C" /product="aldose 1-epimerase superfamily protein" CDS complement(770440..771468) /locus_tag="YNR071C" /note="Putative aldose 1-epimerase" /codon_start=1 /product="aldose 1-epimerase superfamily protein" /protein_id="DAA10612.1" /db_xref="SGD:S000005354" /translation="MSNSNGDNKYGVITIGDEKKFQATIAPLGATLVDLKVNGQSVVQ GYSNVQDYLTDGNMMGATVGRYANRIAKGVFSLDDGPHKLTVNNCGNTNHSSISSLNL KQYKASPVENPSKGVYVVEFKLLDDHTQPNPNEFPGDLEVTVKYTLNVAEMTLDMEYQ AQLVRGDATPINMTNHSYFNLNKVKSEKSIRGTEVKVCSNKSLEVTEGALLPTGKIIE RNIATFDSTKPTVLHEDTPVFDCTFIIDANKDLKTTDSVSVNKLVPVFKAYHPESHIK FEVSTTEPTVHLYTGDNLCGKFVPRSGFAVQQGRYVDAINRDEWRGCVLLKRGEVYTS KTQYKFDI" gene 772657..774351 /gene="HXT17" /locus_tag="YNR072W" /gene_synonym="HLT4" mRNA 772657..774351 /gene="HXT17" /locus_tag="YNR072W" /gene_synonym="HLT4" /product="hexose transporter HXT17" CDS 772657..774351 /gene="HXT17" /locus_tag="YNR072W" /gene_synonym="HLT4" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015795 sorbitol transmembrane transport [PMID:26996892]" /experiment="EXISTENCE:genetic interaction:GO:0015797 mannitol transmembrane transport [PMID:26996892]" /experiment="EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0015578 mannose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0055056 D-glucose transmembrane transporter activity [PMID:10618490]" /note="Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication" /codon_start=1 /product="hexose transporter HXT17" /protein_id="DAA10613.1" /db_xref="SGD:S000005355" /translation="MQSSTESDRDIQDGPDADIHVAPPVEKEWSDGFDDNEVINGDNV EPPKRGLIGYLVIYLLCYPISFGGFLPGWDSGITAGFINMDNFKMNFGSYKHSTGEYY LSNVRMGLLVAMFSIGCAIGGLIFARLADTLGRRLAIVIVVLVYMVGAIIQISSNHKW YQYFVGKIIYGLGAGGCSVLCPMLLSEIAPTDLRGGLVSLYQLNMTFGIFLGYCSVYG TRKYDNTAQWRVPLGLCFLWTLIIIIGMLLVPESPRYLIECERHEEARASIAKINKVS PEDPWVLKQADEINAGVLAQRELGEASWKELFSVKTKVLQRLITGILVQTFLQLTGEN YFFFYGTTIFKSVGLTDGFETSIVLGTVNFFSTIIAVMVVDKIGRRKCLLFGAAGMMA CMVIFASIGVKCLYPHGQDGPSSKGAGNAMIVFTCFYIFCFATTWAPVAYIVVAESFP SKVKSRAMSISTACNWLWQFLIGFFTPFITGSIHFYYGYVFVGCLVAMFLYVFFFLPE TIGLSLEEIQLLYEEGIKPWKSASWVPPSRRGIPSEESKTEKKDWKKFLKFSKGSD" gene complement(774792..776300) /gene="MAN2" /locus_tag="YNR073C" mRNA complement(774792..776300) /gene="MAN2" /locus_tag="YNR073C" /product="putative mannitol dehydrogenase" CDS complement(774792..776300) /gene="MAN2" /locus_tag="YNR073C" /EC_number="1.1.1.67" /experiment="EXISTENCE:mutant phenotype:GO:0046029 mannitol dehydrogenase activity [PMID:26996892]" /note="Mannitol dehydrogenase; MAN2 has a paralog, DSF1, that arose from a segmental duplication" /codon_start=1 /product="putative mannitol dehydrogenase" /protein_id="DAA10614.1" /db_xref="SGD:S000005356" /translation="MTKSDETTATSLNAKTLKSFESTLPIPTYPREGVKQGIVHLGVG AFHRSHLAVFMHRLMQEHHLKDWSICGVGLMKADALMRDAMKAQDCLYTLVERGIKDT NAYIVGSITAYMYAPDDPRAVIEKMANPDTHIVSLTVTENGYYHSEATNSLMTDAPEI INDLNHPEKPDTLYGYLYEALLLRYKRGLTPFTIMSCDNMPQNGVTVKTMLVAFAKLK KDEKFAAWIEDKVTSPNSMVDRVTPRCTDKERKYVADTWGIKDQCPVVAEPFIQWVLE DNFSDGRPPWELVGVQVVKDVDSYELMKLRLLNGGHSAMGYLGYLAGYTYIHEVVNDP TINKYIRVLMREEVIPLLPKVPGVDFEEYTASVLERFSNPAIQDTVARICLMGSGKMP KYVLPSIYEQLRKPDGKYKLLAVCVAGWFRYLTGVDMNGKPFEIEDPMAPTLKAAAVK GGKDPHELLNIEVLFSPEIRDNKEFVAQLTHSLETVYDKGPIAAIKEILDQV" gene complement(777602..778738) /gene="AIF1" /locus_tag="YNR074C" /gene_synonym="CPD1" mRNA complement(777602..778738) /gene="AIF1" /locus_tag="YNR074C" /gene_synonym="CPD1" /product="Aif1p" CDS complement(777602..778738) /gene="AIF1" /locus_tag="YNR074C" /gene_synonym="CPD1" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15381687]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15381687]" /experiment="EXISTENCE:mutant phenotype:GO:0000304 response to singlet oxygen [PMID:11409174]" /experiment="EXISTENCE:mutant phenotype:GO:0043065 positive regulation of apoptotic process [PMID:15381687]" /note="Mitochondrial cell death effector; translocates to the nucleus in response to apoptotic stimuli; triggers apoptosis in cells lacking HXK2; homolog of mammalian Apoptosis-Inducing Factor, putative reductase" /codon_start=1 /product="Aif1p" /protein_id="DAA10615.1" /db_xref="SGD:S000005357" /translation="MTINTKNIVVVGAGVFGVSVANHLYRELGGTYAIKLVTASNYVY FLPSAVRLTVSKDYTKSILPLKNVLDSGIEVIKDTAASFDDKEVVLGSDRAIKFDILV LATGSKWADPIGSTYTFGDNYKEYFEREASRISDADHILFLGGGFVNCELAGELLFKY LEEIRSGKKRISIIHNSDKLLPDSGLYNDTLRKNVTDYLSKNGITLYLNTVGASLDTS PKRIFLGEGSSKYIDADLIYRGVGISPNVPVNSISDLCDKKGFIQVEKNFRVKAVEAG NVFAIGDVTNFRYHGLVKRDNWVDVLTRNVISSLQEGTEASLVDADCLETGHAPSGVS LGPNAGFGQFPLPLLGTINIPSFLISRAKSKNLFSDKMEPLFKK" gene 779916..781040 /gene="COS10" /locus_tag="YNR075W" mRNA 779916..781040 /gene="COS10" /locus_tag="YNR075W" /product="Cos10p" CDS 779916..781040 /gene="COS10" /locus_tag="YNR075W" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:11378903]" /note="Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins" /codon_start=1 /product="Cos10p" /protein_id="DAA10616.1" /db_xref="SGD:S000005358" /translation="MGEEIRLLSSKGLETHSSFCLPEDIFRNRLTWLCSEIRNSGFWI WSLSWLPLAVWWGMASTWFYPLLTSVVLILALIAILPVVQIQYSKYTLSNQLTQLSKE IIKSAPGAYSADWDAVAIHFNSYLYENKAWKTAHFFFNGTDCQEAFRKTILEPAVLRR QNEDPRFSSIEILVPYTEDAVQVYFTKVNAQWRLIHGKKECKLTMLENVKLPKETYRC KLAWSCQRIRISFSPLDFLPDMSDFFICANLSPACLVSYWLIDIFFRMIDDFQNIRPK SMKVDDKMQYLSDIINEQGASPEKWDTIARKTNTRLFEKRVWKNEEFFFDGTDCQAFF ERNFSSLLFSKKSASPRSLNVELWKYIQEAQLSCNYEPLP" gene complement(781511..781603) /locus_tag="YNR075C-A" mRNA complement(781511..781603) /locus_tag="YNR075C-A" /product="hypothetical protein" CDS complement(781511..781603) /locus_tag="YNR075C-A" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /codon_start=1 /product="hypothetical protein" /protein_id="DAA10617.1" /db_xref="SGD:S000028706" /translation="MPIIGVPRCLENPFCAPAKFPLSVKKKIRI" gene 781918..782280 /gene="PAU6" /locus_tag="YNR076W" mRNA 781918..782280 /gene="PAU6" /locus_tag="YNR076W" /product="seripauperin PAU6" CDS 781918..782280 /gene="PAU6" /locus_tag="YNR076W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme; identical to Pau18p" /codon_start=1 /product="seripauperin PAU6" /protein_id="DAA10618.1" /db_xref="SGD:S000005359" /translation="MVKLTSIAAGVAAIAATASATTTLAQSDERVNLVELGVYVSDIR AHLAQYYMFQAAHPTETYPVEVAEAVFNYGDFTTMLTGIAPDQVTRMITGVPWYSTRL KPAISKALSKDGIYTIAN" telomere 783278..784333 /note="TEL14R; Telomeric region on the right arm of Chromosome XIV; composed of an X element core sequence, X element combinatorial repeats, and a terminal stretch of telomeric repeats" /db_xref="SGD:S000028993" gene complement(783287..783541) /locus_tag="YNR077C" mRNA complement(783287..783541) /locus_tag="YNR077C" /product="hypothetical protein" CDS complement(783287..783541) /locus_tag="YNR077C" /note="hypothetical protein, abundance changes with carbon source" /codon_start=1 /product="hypothetical protein" /protein_id="DAA35135.1" /db_xref="SGD:S000005360" /translation="MHGTCLSGLYPEPFTHNSHDYPHFNIYISFGGPKYCITALNTYV IPLLHHILTTQFIHTYFNIPTKSPPKSPKHKNYLSFNFTK" BASE COUNT 241558 a 151659 c 151391 g 239725 t ORIGIN 1 ccggctttct gaccgaaatt aaaaaaaaaa aatgaaaatg aaaccctgtt ctttagccct 61 acagcacttc tacatagccc taaatagccc taaatagccc tcatgtacgt ctcctccaag 121 ccctgttgtc tcttacccgg atgttcaacc aaaagctact tactaccttt attttatgtt 181 tactttttat agattgtctt tttatcctac tctttcccac ttgtctctcg ctactgccgt 241 gcaacaaaca ctaaatcaaa acagtgaaat actactacat caaaacgcat attccctaga 301 aaaaaaaatt tcttacaata tactatacta cacaatacat aatcactgac tttcgtaaca 361 acaatttcct tcactctcca acttctctgc tcgaatctct acataataat atatcaaatc 421 taccgtctgg aacatcatcg ctatccagct ctttgtgaac cgctaccatc agcatgtaca 481 gcggtaccct cgtgttatct gcagcgagaa cttcaacgtt tgccaaatca agccaatgtg 541 gtaacaacca cacctccgaa atctgctcca aaagatattc cagtttctgc cgaaatgttt 601 tattgcagaa cagccctatc agcatcgaca ggaatgccgt ccaatgcggc actttagatg 661 gggtaactcc cagcgcaagc tgatctcgca agtgcattcc tagacttaat tcatatctgc 721 tcctcaactg tcgatgatgc ctgctaaact gcagcttgac gtactgcgga ccctgcagtc 781 cagcgctcgt catggaacgc aaacgctgaa aaactccaac tttctcgagc gcttccacaa 841 agaccgtatc gtcttttgcc tcccattctt cccggcactt tttttcgtcc cagttcaaaa 901 agtactgcag cacctctgtc ttcgattcac gcaagttgct ccatacttta taatacaact 961 ctttgatctg ccttccagac atgcggaaaa cttggctccc ttgcttgcct cttgtcgaat 1021 ccaatacact aattgtttct cttcttctag taatggccag gtaccaagca taatttctct 1081 gtatctgaga gtagatctct ccccttttta cgctaaaaaa tttcaaatac cctacagggt 1141 ccccatgata tggctcgatg tcttccaagt attctttgta ttcctcgtca tttcgcagca 1201 ttctctccac agctagtgct tcccaagcca tcctccgata cgatactttc tggccagccc 1261 aacagacaca gagctcgaac atcttttgac agcccttgca taatccgtat tgtgtgaata 1321 ctccctctgg gcagaagtat acgtcaatac catagaggaa aagatgttta atttcgtcag 1381 accgaaatcc aagaaactgt aagacattca tattctcgga agtattggga aattgtgctt 1441 tcagtttctt tctctctagc aaaaccattt gactcccttt ccgcttatac gactctttgt 1501 taatgtcggt gactggatgg aatctattat cctcagcatt gccatcttta ttggcgtcct 1561 ccttggcact agcgttggta ctttcagtgg tagtggcatt agtgctggag ttggtgctag 1621 cagtggtagt ggcattagtg ctggagttgg tgctagcagt ggtagtagca ctagtgttgg 1681 agtcggtact ttcggtggta gtagcactag tgttggagtc ggtactttcg gtggtagtag 1741 cactagtgtt ggagttggta ctttcagtgg tagtcgcact agtcctgacg ttgatgctgg 1801 cagtggtagt agcactagtc ctgacgttgg tgctggcagt ggtagtagca ttagtgctgg 1861 agttggtact ttcagtggta gtcgcactag tcctgacgtt gatgctggca gtggtagtag 1921 cactagtcct gacgttggtg ctggcagtgg tagtagcatt agtgctggag ttggtagtcg 1981 cattggtact ggcattagca ctaccatgaa tgcacgtgtc gctgtcctca tcactgctgc 2041 aatactttct gcacctgtca ctgctattgc tctcctggaa gctagacggt aacgcaacga 2101 tcgacatgga agctgtcgcc tgtttttcag ccaatctgtc cattctttct atcagttcca 2161 ctgtgtcagc agacaggtct gtcctggagc cacagcatcc aacatgctgg cccttttttc 2221 ctttctttga ttcaagtcca tagaactcgc gtacctgttc ggttatacag ccttccttaa 2281 tcggtggtaa ttcaccctta cgattccttg ccgcccaact gttttttcta gataatagat 2341 aacagaggcc cccatctctt agtctcccta cgccttgaat gagctcaata atattaagtc 2401 tattatcaag catgatcacc atcatcaatt gcttaatgtc aattccttca gtcactaatt 2461 tcgttccgat gagaactcgc atgctaccgt cagtgacaaa ctcctttgtg cgagacacct 2521 tttctgcagc acccagcttc ccgtgtatcc ataccaccct aaaatacttt ctccaagagc 2581 aggccaattc ttccacttcg ttggttgtgc ttgcaactac aatggccttc gactctggtt 2641 caatttcaaa gagggctaaa agaagcttca gtgcttcttc gggctgtgat tccactttct 2701 tccaaatttt atgaacatgc cctaaaggca cctcggattt ctccttgatt agattaaaca 2761 tccgtgttgg atagctggat agacctctgc tgagatcttc cgaccgtttg agctcgttga 2821 tgtccatcga cttcttggcc agtcccgtaa gcccaatacg ctgcaacgca gcatcagcta 2881 cagcctcagg tgctgtgccg ctcaaaaaga ttgctttctc aaaagcgtca aaatcaaggt 2941 tagttatgcc cccaaattgc gactgccggt agacctccgt ttcaaagttg tgaaactcat 3001 ctacaatgag gtaacccaat tttacgttgt tggtcctaaa ggtgcactca acaatattct 3061 cccacgcagc tatcctgtct gtgaaattag tgctagcaag atcatcgtag atccccacgt 3121 ataaatcagt aacgccatcg caaccttctt caataaagtt tcttacaggg gccacattca 3181 agcaaccgca tcggctcaac ctgatcatgc aattagcaag caacactgtg tacggtacaa 3241 acagaaacga cacatatttc acgtcgccct tagacgccag tgctatcaag gggagatgaa 3301 ataactccgt cttaccatag cccggtgggg cctgtactgc cacagagggt gtgtctgcca 3361 tgtatatttc atgacataag cgcaactgat gcaagtccct gaattcaaag gagctgccaa 3421 agagtttctg gcctgcgacg aggatatcgt ttgtactctt gggctctcgg ggcctttttc 3481 gcgttactct tgaaattttt tgatgatgat ctgaactcgc cgcctcacct gccactacgt 3541 cttccgcatt ccgagtacta gagaatgaac aatggtagtc gctttcaagg cctaaccatt 3601 gaatccagcg ctcggaagct cgttcctgca ataaagtggc ggtcgtccca ctgacactag 3661 ttaacgaaaa ggaatccaca ccgtaaatat ttcgccctgt ttgaacggaa tgattggcca 3721 tgagttcact cgtcgccgac tcgtacaaat ctgtttcaaa tctgctacct acgcagtgcc 3781 gtcctagggc aatcaacccc tgacgcatct cccgaaaatt cagcttctga ggtgcattct 3841 tcggaagttc cctcatgtac tgccgaaaag ttgcgtattc aaccagacag cccttcgcgg 3901 tattcagaaa catgtaggaa tacaaaacta tcctcgaaat gtctcgattt gttacttgat 3961 ctggatcctc aaatcccacc acatccatcc aaggatcatg attaaaagcg tcataactgt 4021 taccaagcgc acatatttgc atttgcctta gcacagtgac aaaataaaac acgtaatctg 4081 aagtgagtcc gtcaagcgtc ttaagtcgag gctccgatga accgttcttg ttgtaatcag 4141 tgtacagttg gatgcgtctt gttgtatcat cgacgtatac gttgcgctga ggaccggcaa 4201 aagcgagtag ctgaagctct ggataacggt aagggtatcc tacggcaaaa tggatcatcc 4261 acataagtgg caccgtaagc tcgtcaattg caacagtgac tttattttta agagccgcgg 4321 tcattttgtt agtatctctt ctcaacttgg gcagcacaat ttcacgatat ttaacaggta 4381 tcatttgaag gaaagaatcg ttctccagat actcgtcaat tcctcgcttt ggctctctga 4441 acaaaacttc tcgattacgc aaaatgaggc tggcaatatc aaccactgta ggcatataaa 4501 agcagtcgtt caattcttcc caaaggttat caaactgagc cttgcatgca aagtaaaagc 4561 cgcggacata ctcgcgatta aacagttttc cacatactga tacaccatca gaagaaggta 4621 ccaaagttat tctataagag tccttcagcg cggtttcctg cgctacttcg tggtacagaa 4681 ttttgatcca tttccacatc gcaacgccgt tgttgtcatc aaatatatct aaatcccttg 4741 cggtacaagc acaagacgac accaataaag ctttcacggc atctagtgtt tttctgagtc 4801 ttcgtggagt gttaggactg cgcaacttac atactttcaa gccatgctcg tccacagagg 4861 gaataatggg ttcttcattc gtaatggatc gatcctcttc gtcaccagcg ccaccacggg 4921 gacccgcccc gaaattgagc gcacatgctc gcaagataat atgcaaaata tcacccaatc 4981 ggtccttttt gttcatcata tcgttacata tctgtgaaaa gtactttatc tcagtgggtt 5041 tacgtgggca tagatcacgc ttcagccgct ctgtgtcgac tttcttttcg ccaggtaaac 5101 ttgcttggta tgcagaaaaa atcgatagct catctacgtg tagtaacaaa aacatgtagg 5161 gtgccaaatt gtatccatat ttccttatgg tgcttttctg aagacccctt acaataggtg 5221 tgccagaaac aaagtcagtg aaagtacgca tcgtagagct gtcgttcggc ctggcactcg 5281 ctatttcgta acaacgttcc aggacacgga aactcaactc attatagtat cctctgttga 5341 ggtaaaaaag agaaagggta tcgtaatcct ttctattgaa tttcaaagta tgcacttgaa 5401 acaacgtgta gaccatcaag ttgattttct tgggaataag atactttgaa gggattggtc 5461 cgccctggaa atctggttcg tcttcaacaa acgtcaggaa cttttgtaca tttttcccga 5521 ccatgacgga aacgacaatt ttttcaaaag accttttcct atccattgca ccagttctga 5581 attttaccac tttgattaga ccagactttt cgtcttcgta gaatgaccgc acttccgtgg 5641 ggatcgattc aaataaagtt attgagggac aatgtaccaa gtcgtttttg ttatttagag 5701 ccgactcaaa ctcgtcaaag tttgcttttt caaacttacg cctatcggaa actttcattt 5761 tatttttgta agtttcgaaa ttaacaatag tatgttgatt gttatgcttt ttgacaagaa 5821 atccatcaat ataaacaaaa gattgtccag tttccgtctt atcatcatct aagaatgtaa 5881 taattaagct attgagaaga tgcagaatct gcgctatgca ggtgcaaatc tctagcagca 5941 gcaaagtaaa ttcagttagt aagaaatctc actaagataa gcgactgtct gtccccttca 6001 agcacaacat agaaagcaga aggatgtctc attcatcgct tgatttccgg cctgcaaaaa 6061 taaagtagtc ggtacgtacg ttcgttttca atttccatgg tgcacagtat cttaactatc 6121 tgcttagtcg aggagaacca ggattctgtt cgttgctcag ccgcttcgtg gatattctct 6181 tggatacttt aaatatggac ctacgcttag cctgcgctta gcctacaact tcttccgctc 6241 tcgaaaagac caatataata gaaagttata aattacattt ccttattagg tatacgacct 6301 cgcgcttcga agtagaggag ccctttttgg cgtacctaca tatggcgcgt cagacagaca 6361 aacttccccc aaaaatgtat taccccgccg aataagaaaa cagacccatt cacccacgac 6421 gtatcaagtt acttccttgg tgcaatgtcc cactataaaa aaattccttg acgctagatc 6481 gttggactaa aatctgcgtc acaatcgcct aaacaggaaa tattgcctat tttcgtacaa 6541 ggttacttcc tagatgctat atgtccctac ggccttgtct aacaccatcc agcatgcaat 6601 acagtgacat atatataccc acacccacac ccacacacca cacccacaca cccacaccac 6661 acccacaccc acacacccac acccacaccc atcacaaccc taaccctacc ctattctaac 6721 cctgatgaac gtgtctctca acttaccctc cattacccta cctccccact cgttaccctg 6781 ccccactcaa ccataccact cccaaccacc atccatcact ctacttacta ctaccatcca 6841 ccgcccatca taaccgttac cctccaatta cccaaatcca actctactac cattacccta 6901 ccatcgacca tctgctactc actatactgt tgttctaccc tccatattga aacgttaaca 6961 aataatcgta aataatacac atatacttac cctaccactc taatcccact accacatgcc 7021 atactcacct tcacttgtat tctgatcggt catacgtaca cggatgctac agtatatacc 7081 atctcaactt accctgccat aacattccac tccactccat ggcccatctc tcactaaatc 7141 agtaccaaat gcacccacat cattatgcac ggcacttgcc tcagcggtct ataccctgtg 7201 ccatttaccc ataactccca cgattatcca cattttaata tctatatctc attcggcggc 7261 cccaaatatt gtataactgc tcttaataca tacgttacac cacttttaca ccgtatacta 7321 accactcaat ttatatacac ttatgccaat attacaaaaa aatcaccact aaaatcacct 7381 aaacataaaa atattctatt cttcaaccat aatacataaa cacactcaat tgcgtatcaa 7441 taccaccatg acgtcattaa cttaaatgtt ccttaatacg tcataccact atgctctatt 7501 ccatatattg taatataact gtactctata gtcatacaga cgcttttact tcaccccatc 7561 ttctcatact attgtcatag aatctcacac tgacgcatga ttaaaacgaa taatttttac 7621 tgtaagggct gccatccgcg ctctatcctt ttgtttgcaa tatttatata cagaatctca 7681 aaacaagcgg gagaagtgct aattacccag aggtcatgca taatctgagt accaccgtac 7741 ctctaggttt tgctttgatc cgttttacag tgacaccgaa cataagggga agctattgac 7801 atggtatcga aaggttgtcc acattgggaa gtaacttggt tctatgaatc ttcatgtcag 7861 atacgtagga cagactcttc ctgtgtaaat atttgtgaca gctacgtcta ttttctacta 7921 gatgtttaca cagttttgtc acaggaaatc tacgcttaaa atatgtattt cattcaagcg 7981 gtaaccgctg tacgagcagt gacattgctg gtcgcacctt aaatgtaaac caacgttacg 8041 gcacaccgtg atgtacccgc attaaagttt tgtaaattcg ttattacgat tatcgagttg 8101 gctagataga aaaccggaaa tgaaatggat gcccttttcg aatagctgag tttctttgcc 8161 taaaatagcc caatattgtt tccctttttc tatcacgagg ttactgagcc attgcatgaa 8221 cgcgcgcgcc tcggcggctt tttttttctg ctgtgctgta taaaagcgaa aagccagaag 8281 ttactatctc gaataaaaaa cccctcgaac tgccatctca ctaccgaaaa tgaaagagaa 8341 tgaacttaaa aatgagaaga gtgtagatgt attatccttc aaacagctcg aatcccaaaa 8401 gattgttcta cctcaagatc ttttcagaag cagctttacc tggttttgtt atgaaattta 8461 caagtcctta gcgtttcgca tctggatgct attatggcta ccacttagcg tctggtggaa 8521 actttccaac aattgtattt acccacttat agtttcactt ctggtcctgt ttctgggacc 8581 aatatttgtc cttgttattt gtggactttc tcgtaagcgt tccttatcga aacaactcat 8641 tcagttttgc aaagaggtta ctgaaaacac accaagttct gatcctcatg attgggaagt 8701 tgttgcagca aatctaaatt cgtacttata tgaaaataag gcttggaata ctaagtactt 8761 tttcttcaat gccatggtct gtcaagaagc gttcagaaca acccttctcg aaccattttc 8821 tttgaaaaaa gacgaagctg ccaaggttaa gtcatttaag gattccgtcc cttacattga 8881 agaagcattg ggagtttatt ttagagaagt tgaaaaacaa tggaagttgt ttaattctga 8941 gaaatcatgg agccctgttg gcctggaaga tgctaaactt cccaaagaag cttaccgatt 9001 taagcttact tggtttttaa agaggatttc caatattttt atgttgatac cattccttaa 9061 ttttttgtgc tgcatatatg tgtcacgggg aatgtgcctt ctattacgca ccttttatct 9121 cgggtggatt cttttcatgt tggtacaagg tttccaaaac atgaggatga tcgttttatc 9181 cgtgaaaatg gaacacaaga tgcagttctt gtcgactatt ataaatgagc aagaaagtgg 9241 tgcgaatgga tgggacgaaa ttgcaaaaaa aatgaatagg tacttgtttg agaaaaaagt 9301 ctggaagaat gaagagtttt tctttgacgg gattgactgt gaatggtttt ttagccactt 9361 cttctaccgc gttctctctg caaagaaatc tatgcgggct ctatcattga atgtggaact 9421 atggccatat attaaagaag cgcaattatc ctgcagtgag gagtccttag cgtaaagata 9481 aatacaactt tttcaattta tatattttgt agtttgtcag ctgcgaataa ccaaaacgag 9541 actacttttt accattacaa ccattttctt tttccctatt tctcactggt tgacagaaat 9601 cagtgtgcta tcatcctacc atatgcgcta aacttattgt ctttctcctc ctagagatgc 9661 tgtattccat gcatattctg aacgatgggt tggtgttttt atcaagcaag gttaatcaca 9721 tggcgtggct tgctccacac atcagtagaa aacgcatacc gcagcggaat ccttaaataa 9781 taagtgattt tactgttcat caactacaat cggactcttt cacaattacc cttcttgttt 9841 tccacattta ctgttaaatg aagggatgta cagaaggctt aggaaaacct gtgctgaata 9901 ctggatggac actgcattcc cacagtgaaa cttttataga tacactgtca gttattttcg 9961 aactttcatc aagttgctga gttttagtat ccctttgcct tagctatatg tttgaatgag 10021 caaaatattt gcaatgtctc tagctttctt gaaatattgg tttatattga gggcttggta 10081 agatttcaaa tttcactttg aaatactcag gagaaaaatc atgctctttt gataatttgg 10141 tgactaaaca tacataaaac agtttaattt tgggtggtaa tggctgtgtg actagctata 10201 gaaagaaaaa aattaaaaaa aaaaaaaaaa atcaagtagt tcctgcactg cgacgtccat 10261 tatagcatta tgaattggtc cctgatttac gcatgcgata aactattttt agcgcagccg 10321 catattatcc gagaataact tccgacataa gaaaattcgc agaaaataga taaaaaactg 10381 ctcttggcat tcttcacttc ctctattaca cactgtgtca taccacaatc atctcacagt 10441 atgtatttgt atgtttatac atgctataac gtaaaacaat gtagaatata tatctaaata 10501 cctcacggtt ttagtttagt gcagcccaca tactactttt ttccttttgt ttttttttat 10561 atttcaaagg ttaaactcgc ttagactatg tctataatat aaaaaaaaaa atagctctat 10621 tccgtttctt ttattctatt tgatatttcc atcacacttt catcttaatc acggatgtat 10681 actgataata gggttgactg cgcctgtacg gattacagtg ccctcttcaa ttggaaaatc 10741 caagctttca agatgcgtaa ctgttattca aaggatcctc taagataaaa cacagatcgg 10801 cagatccgag agttggcttc tgtgccttgg gctcaaattc ctttcccacc tcattcaaat 10861 tgatttttct gactccaaaa aaagacaaag ccctgcgata gttcccgaat gttgtaacat 10921 caaagccaag cactccttta tagaagtcgc atgaacgttg aatactagca gctggtgaaa 10981 ctacagggtc taaactaact agtatccata tcgttttgag agcattgaaa gtatacggag 11041 tacaagctgg gttagaagga atttttatct taacagcaat gaaaatcaac tttctagact 11101 gaatccctca agaaaattgc aaaagactaa ccgatactgg tttaaaagag aaagatgtca 11161 aatatgcgga gttataccat caaacaactt tggacggccc cgaaacaaat gtccgcaaaa 11221 aagatcttat taaagtgcat ggacactatc atttctataa tacaaaatac tccaccgcac 11281 aatagtttgt cgggaagtca tcaatcaatc ttgtacgagc tttacaaata actttttagg 11341 atcggtcccc tcataaaatt atatataaat gggttagttt ccttcttctt ctgttaacat 11401 gaagttgctt cgtactgttt tttgccttgc tcctcttcaa aagaatcaat catgtcacag 11461 tacggatttg taagagttcc tagagaggta gaaaaggcca ttccagtggt gaatgcacct 11521 agaccacggg ccgttgttcc gcctccaaac agtgaaactg ctaggcttgt tcgggaatat 11581 gccgctaaag aattgactgc ccccgttcta aaccactctt tgcgtgtttt tcaatatagt 11641 gtagctatca taagagacca atttccagca tgggacttgg atcaggaagt tttgtacgtc 11701 acctgcttac ttcatgatat tgcaacaaca gataagaata tgagagccac gaagatgtca 11761 tttgagtatt atggtggcat actttcaagg gagcttgtat ttaatgcgac aggtggaaat 11821 caggactacg cagatgcagt aactgaggcc atcattcgtc accaggattt gactgggact 11881 ggctacatta ccaccttggg gctcattctg cagattgcta ctacgcttga caatgtcgga 11941 tccaataccg atctgattca tatcgataca gttagtgcca ttaacgagca atttccaaga 12001 ctgcactggt tatcatgttt tgctacggtg gtggacactg aaaactcgag aaaaccgtgg 12061 ggccacacca gttctttggg tgatgatttt tcaaagaaag tcatatgcaa tacatttggg 12121 tataactaaa taggtaagtt tcaatgaggc gagttcagaa tgaacagtga tgatctcctt 12181 tctccataac tatactatac gtccctttta tttactgtag tttttaagaa caaattctct 12241 gatgaaccag tcgtgaaacc gtatatcgtt ttctgccaat tccggatgaa atgatgtcgc 12301 aagaatattg tttttttgct tagcggcaac aattagttct tgaccaccat tatccttccc 12361 atctaatttg tacaggacct gcacatgttc aggatccagc acctcttcta ttactggggc 12421 tcttataaaa gtagcaggaa aatcattgca gtgaggaata aagtttgaaa agtcgcaaat 12481 ccgggtagaa gactgagctt gtctcccaaa tgcatttctt tttactttaa cctttagtaa 12541 attcagcgtc ttgaccagtt tttcttcgtt agataattgt tgtgaaatat aaatcatacc 12601 tgcacaagta ccccaggtta ccttgcttgg gttgtgtacg aatgcgtaga gatcgtcgta 12661 aaatcctgtt ctttctgcaa taagggacat tgcagtcgac tctcccccag gtatgatcaa 12721 tgcatcacat tgagctagtt gatttttatc cttcactgtc atcacagata gttttttttc 12781 atagaaatcc ctgttttcga cgatgcattt ttctacgtgt cgcacatgtt caatgaacgc 12841 accctgtaat gccaagactc cgataacgac ggtcattttt gagatattac tcttgtcttg 12901 gccccagcaa ccggggtcat ggtaagtgtg cttgctactc aaacagaaaa aaatgggctt 12961 ttatcaatga ataacttttt ttttttgtag ctgaatgatg aaagatggct caactattct 13021 tacagtttcc aataaagtga cgcgccgccc aatggcataa cagtagtagg cacattatat 13081 cgtttgaatg gcaaaatgtt gtggcaagga aagatcagaa ttatttgttc atgtggaatg 13141 aatttcacac acacacacac acatatataa aactagtatg tttctccacc atagtcacat 13201 tattattcga cccttctagg aaaggaacta taatagaaaa ataagtatat cgtaaaaaag 13261 acaaaaatgt cagaattcaa ggttaaaact gggcttgccc aaatgttaaa gggcggtgtg 13321 attatggacg tcgtcacacc tgaacaggct attatcgcag aaagagcggg cgcttgtgct 13381 gtaatggcat tggaacgcat tccagctgac atgcgcaagt ctggccaagt atgccgtatg 13441 tcagatcctc gcatgatcaa agaaattatg gaagctgttt caattccggt gatggcaaag 13501 gtccgtattg gacacttcgt ggaggcacag atcctggaag agctgcaagt agactacatt 13561 gacgaaagcg aggttttgac tccagctgat tggacacatc acattgagaa gcataacttc 13621 aaggtgccat ttgtttgcgg tgccaaggat ctaggtgagg ctttgagaag aataaacgaa 13681 ggtgctgcaa tgatccgtac caaaggtgaa gcaggtaccg gtgacgtttc cgaggccgtc 13741 aagcacatca ccaagattaa ggcggagatc cagcagtata aagagaattt gaagaccgaa 13801 tccgattttg cagctaaggc cacagaatta cgcgtccctg tcgacttgct gaagacaaca 13861 ctatcagagg gaaagctacc tgtagtcaat tttgctgctg gtggagttgc tactccagca 13921 gacgctgctc tattgatgca attgggttgt gaaggtgttt tcgtcggttc aggtatattc 13981 aaatcgtcag atcctgagaa gttagcatgt gctattgttg aagccacgac tcactacgat 14041 aatccagcaa aactgttgca aatttccagc gatttgggtg acttgatggg tggtatttcc 14101 atccaatcaa ttaatgaagc aggaggcaaa aacggtgcaa gactttctga aatcggatgg 14161 tagaactagc gatgctcaca caacgctaat ttgtttcctt cgaaggggca gtcggctatt 14221 gtagtttcta tatattatgt agcacaacat ggaaaccata ttcagccagt ttgtatatat 14281 gagaattaaa cgttaaaact ttttcatcct atcagtctta cacattggcc ttgctaaagg 14341 gcacaatcgt tcacgtatat acatatgtat gtttacgtat atatatatgt gtttacaaat 14401 atgcatgtat attcttttcg aggaagatta ttatatgcta ttaggcgatg agtcggctta 14461 attttttagg gggacgagat tggcgcgtta gtgcataaag acagcaaatc acctggaggt 14521 gacaacatta atgcatttat cggtttttgg ctatgatgca atgagtacag ttccaattga 14581 acggctcatg aactatgaaa tatacgaatt attcaactag cagaaggctt gaaatattac 14641 ttattcagat tatgaaaatg gtgctgttat agcaaaataa gcaacatcaa tctcttgcga 14701 cgacagcaaa caaaacatat aaaaacctcg tattatcatc ttcatgaaca atattcttgt 14761 ccattctttc gttcttttac cttttcaatt ttataaaaat accacaacaa caataaacac 14821 acttccaagc tatgtctaca gacaagatca catttttgtt gaactggcaa ccaaccccat 14881 accatattcc aattttcttg gctcaaacca aaggttactt caaggagcaa ggtctagaca 14941 tggccatcct agaaccaacc aatccttccg atgtcactga gttaattgga tctggtaagg 15001 tcgacatggg tttgaaagcc atgattcaca ccttggctgc caaggcccgt ggtttcccag 15061 tgacctctgt tgcctctttg ttggacgaac catttaccgg tgtcttgtac ttaaagggca 15121 gtggtatcac tgaagacttc cagtccctaa agggtaagaa gatcggttac gttggtgaat 15181 tcggtaagat ccaaatcgat gaattgacca agcactacgg tatgaagcca gaagactaca 15241 ccgcagtcag atgtggtatg aatgtcgcca agtacatcat cgaaggtaag attgatgctg 15301 gtattggtat cgaatgtatg caacaagtcg aattggaaga gtacttggct aagcaaggca 15361 gaccagcttc tgatgctaag atgttgagaa ttgacaagtt ggcttgcttg ggttgctgtt 15421 gcttctgtac cgttctttac atctgcaacg atgaattttt gaagaagaac cctgaaaagg 15481 tcagaaagtt cttgaaagcc atcaagaagg caaccgacta cgttctagcc gaccctgtga 15541 aggcttggaa agaatacatc gacttcaagc ctcgattgaa caacgatcta tcttacaagc 15601 aataccaaag atgttacgct tacttctctt catctttgta caatgttcac cgtgactgga 15661 agaaggttac cggttacggt aagagattag ccatcttgcc accagactat gtctcgaact 15721 acactaatga atacttgtcc tggccagaac cagaagaggt ttctgatcct ttggaagctc 15781 aaagattgat ggctattcat caagaaaaat gcagacagga aggtactttc aagagattgg 15841 ctcttccagc ttaaacgtgc ttcgtcactc gttcagccca gccttcctct acgacttgtt 15901 tatgatttca cattagctgt tgtttcctac tcgatatata gacatacata tttacgtatc 15961 agagcatgta tacaagcttt aaatgaactt cgtttatctt aacactttat ttccttgcaa 16021 aatttgcaca cactcggtgg ataaggcaac tgcgtataat ttgtagcttc ttttcaaaat 16081 atagtagatg gatattaaca taaaataatc actttaacta attgtcaaaa gctatcctgg 16141 cagacatcga tgtgaggggt gaaagcttct tggttaccgc tgggtcatct cctattaaac 16201 ttttgggaaa gccaacatca aaaggaacaa tactttccag gtattctatt tgttccggtg 16261 ttaatttaat actcaaagcc tcaatgttct gcttgagatg ttcaattttc cttcctccaa 16321 tcaatgggaa aacatttttc gctttagagc gaacataggc aatagcgata gcagtaacag 16381 actctgttcc atgttcctca gcaattttag tcaatgcttc gctgatttta acctccaatt 16441 ctgtttgttc ggggccaccc acaaaagtac gcagaccctc tccattcttc ttccgttctt 16501 ccattgcttt tttactctga aatcttccac ctcccatgac atcccatggg gctagagcca 16561 taccaaaatg cctagccatt ggaataatat cacgctcaaa gtccctgttc aatacattcc 16621 atttaccttg atagacgcta aaaggagttt taccatgaga tgtagcgtag taatttgccg 16681 cagaaacaac ccaagcaggt gtatcagata ctcctaaata taggaccttg ccctgctgaa 16741 ctaaaatatg caaactatcc ataacttctt cgattgaact catataatcc caccagtgaa 16801 tgtaaagtat atcaatccaa tcagtttgca atttgcggag agaatccctc acactcacat 16861 gtaaactacg cttgtgatta ccacagtagt tggcactttt accaccacct acttcatact 16921 tcttataatc tccggtaaac ttggtggcaa ttacaatctg gtcacgcagt tttcttgatg 16981 ccatccattc acctatccaa atctctgact cttcattttg gtaactgttt gcagtatcaa 17041 tacaattacc tccagcttca taaaaagcat caagaagttc aaaggcctgt tccttattca 17101 tagagcccat aaagcctgac catgcgtcgc cgattgaagc tcctcccaga attagcggtg 17161 aaacccttat gccggcagtt ttagaaagaa ccctgagacg tcccaattcg gtaggtggtt 17221 caggtagagg tttaaacaag tcagtcatgc tgaatagtgg ttttttatgc aatagacaat 17281 atgttaagta aaatacaaag ccgttcagct aattggttag ctagttaatg aagagaagaa 17341 cagcatgcat ccttgacttg gaaatattgt catacttaaa tatggttgga aattttgccc 17401 cccggtttcc ttgaatacga acaatgcaac ttatttgagt cttcgtacga gatctgctta 17461 ctggttttgt acagcgctga aagcgaattt gaaaatatat gcaattagaa gagagtgaat 17521 cagatgagga tagggttaat actgtaaaat tattaccaaa tattgaatga catataaaag 17581 tcgtagtaac cgaatttgtt ttttattatg aataaagact tcttgttttc gcatacttcg 17641 atgatttaag aaattaaaag tcatttaccc aggcgtgatt ataaattata ttggcaccgc 17701 tttatcaaca gcggtgggac gagacgttta gatagtaatt acaatagaaa tacaactgtt 17761 tcaatattaa aatatctcta gtatgtaaat aacacatata ggcaattttc ttcgaaacgt 17821 atgggacgcg gttgatgtat gaacggaacg catcaattaa aggtttgaga aaagtctttt 17881 gcaaaaaaat tgagtttgca cttctcatac acaattggat agcgtcttaa gtgcctttta 17941 ttcacttttc ttcttttgtt tcacattatt tatattcgta tatacttcca actctttttt 18001 tcaatagaat tcattgtcat gctcaacatg taggtccctc gcatattgcg aaccaccctt 18061 cgtatcttta gcctcggcag aatcttcttc aacatcaccc aaatcttcgg catccctagg 18121 tgtgtgattc aactgaacac taggggcata ctttgtgttt tccaaattag caaatatatt 18181 ggtcattacc ttgtcaagat attcgggagt atttacattg aacatattcg aaggtctaac 18241 acttaactta taatctggac cgtaatattc gtaatattca ttgtacggta aatctttatc 18301 caagacaacg ttatttagta gacctgtttc aaagcaccat gtccttgcaa catttctcat 18361 agtatagcct cctccaccaa caaccatcat tgggatccca aaggatttca catagtttac 18421 acaattagca tggccttcca tggaaagatt aaagcaacca agacgatcgc cggacaagga 18481 gtccccacca cactgtaaca cgacagcaga aggttgatac cattccataa ttttttttat 18541 cacaggttca aacacagatc tatacgtagc atcgtcaata ccgtctctta atggcacatt 18601 gaccgcgtag ttttttcctg cacccacccc tatatctctc agttcacctg tgccagggaa 18661 aaactcacca tatttgtgga aagaacatgt catgacacga tccgttgtat aaaacgcttc 18721 ctctacacca tcaccatggt gcacatcaat atcaatatac agaactctgg ggtggtatcg 18781 tagtagctca ataatgccca gtactatgtc atttaaataa caaaacccag aagcttccga 18841 tttttttgca tgatgcaaac cacccgcata gttgacagca acatcacatt tgcctctatt 18901 cagacgagca gctccttcca tagagccacc accagatatg ctacagtact catagagccc 18961 atcaaagaca ggacaatcat ctccgacatt aaacttgaca ctttctcttt taaacatttc 19021 taaattatct ggagtaaccc tcgataaaaa atcaatgtat tcatcagtat ggaactgaca 19081 catttcttgt ttcgttgccg gcttagctct gtaaatttcc atcttcttgt acaagccata 19141 attcataata agggaatgtg ccattcttat tctatgcggc ttcatcgggt gacctgctcc 19201 atatgcatag ttcccaacgt ctgcatcgta aaaatatgca acgcgtcttt tatcgcttgg 19261 cttgaccgtg atcggatcaa aaggtgttgc ttcatatacc atctgcacgg atatcgagtt 19321 gtagccacga atgttttgta tggcgcaatt gttttatgaa cctttatggt tattacttca 19381 aatttttatt atgtataatc aactactagt atcttttctg tttttccctt tcgatagata 19441 ctatgagccg gggagggtaa gtaaataaaa agataaattt caaggcaaaa tatgggacat 19501 atatttacaa atttacctat acgctctgag ttgatattac ttaagcacct tcaaaattag 19561 ctctcaccgc ttcataatga ttcagttcag cccgcgacac acttggggtg agctgctctt 19621 gtgctttcaa gaagtcttcc atttttacga caaccttagt atcctctttt gtcgcaatct 19681 tatcaaacca gcgacgtgta gaaatattct ctcccgtcaa ttcgttatgc tgagaaactt 19741 ttttttctac catgcgtgca attcttgaca tggcgttaag cattgcatct gagcagagag 19801 cataaaaatc tgccccggtg taattaaatg gacatagctt tgccaactca ataagcttta 19861 cgtcgttgtc gagcacgaat ttgcgagtca gagcctctaa aatattcaat tgtttggtat 19921 ccgtatccgg aatgcctaaa tataacaatt tatcgaatcg tcctggtctt agtagtgctt 19981 cgtccaataa gtctggtctg tttgttgctc cgataacaaa tacaccgtca gcgtcggtac 20041 tcataccatc taactctgct agtaactgtg aaacgatacg atccataaca ccacccgaat 20101 caccttgatt accacgtttg ggtgctactg aatcgatttc atcgaaaaat atgacacaag 20161 gtttagcctc tctcgccttt tgaaacactc tgcgcacatt agcttcactc tcaccaatgt 20221 acatattcaa cagttcaggg cctttaacac taaaaaaatt taaagaaaaa tttgttgcaa 20281 tggccttagc cattagagtt ttacctgtac ccggtggacc ataaaaaaga ataccgcttc 20341 tctttttcat acctgaggta aataattcag gatgttttag cggcatgtct attgtgtcca 20401 atatttcacc tttaacaaaa tcaataccac ctatatcatc ccaagttacg ttagggattt 20461 gtggggcacc aatcgaaacc gagaattcgt tcctagcttt cgaagtagct tttgataaat 20521 cctcctgagt gatcaaaatt gattgcggaa gccatccaca cttctttgat tcttggtaaa 20581 aacgcgcagt agccgtcatt cgtgccgttt ccacaattga tttgatgtct aaaggagtta 20641 aaccagcaga atatgaagag agtgatgaaa atgaaatatt atccatgtaa gatactggaa 20701 ccttttgttg aacatctctg tttagttcat gtgaagataa gtaccactga aagatacgca 20761 gtctctgtgc ttcagacgga acgggtacga gaatctcaaa tctcatatgt gatctaaagc 20821 tggaaggcac gttatctatg ttatttacgg agccaacaaa tgtagttcct gggaatttaa 20881 acgtaaaatc gtccagaagt ttagacattt cgaagtttat agatttttgt aatttgattg 20941 cctctggatc ttgattagcg tttacgtcaa gcaaaattga atccaaatga gccaaaaaaa 21001 tcacagcagg tgatgcgtac ggtaggacat tttcacattt agccctaatg taaccaataa 21061 tcttagatgt tgaatccagt tgtcttgaat ttgaagtgag cgaaaggcaa tctatctcca 21121 gtagatgtat accaagatat tttgaagcaa atctcaccat tgtagccttg cccacattgt 21181 ttgtagtgga atgaagtaac acagaggcat ttagggtgat tcccctttga gaacaattga 21241 aggaagtttc taatatgtta accaattgtc ttacataggg gaagatatgc aaatcatagt 21301 aaaaagtttc agcaaaaccg taatatctct gaagattgga tctactcaag ggtaatggtc 21361 ttctgttagt gatattagtt gttattagct tcgtccgatt gggatcaata ataaaatgag 21421 aattatcttt agagaagcaa tcgagctctg cgcttgtgac aaagaaccat acaagggaat 21481 cgttcttgta gtactgccct agctcatctt cgtcatcaga ctcatcattt tcctctgcta 21541 tattgagatc agccatactt gaatcaaaag cgattgggat taaatcattt tgacaaagaa 21601 tccttttgct ctcgctaaaa aactttttca aggttgttag aataatattt tgaaagcatt 21661 tctgagattg aagccagcct ccaactcttg agatgaaaac ttgattagca atgggaatat 21721 ctgtatggcc tatattggac tttgatattg tcacgacgct gcagtctgga aagcttgcta 21781 ttattttggg aggtgcgtat attgttcttt ttttaaagcc gttggggagt agtaaaacaa 21841 acagcttaac tagcctgacg caacccatat ttgacactgt tataaacgat ccacttgtga 21901 catccaggcg cagtagagtt tcagcgtctg taaaggcata tattgaatta tcatcattga 21961 tgtgaggtgc aggtcgcaaa agatctcttg aaattgtgca ggggagagat tcaagatcaa 22021 ttgataaagc agaatttgtc cctattttag gtaatgcata ttcttcatct tcgttagcat 22081 attttagagc acttagtttc tgctcagtat catttactaa tatcaattgg gtttctgtaa 22141 aatcaacaag gccctgcggg aaaggtgagc agtttaaaat ttggcaaaga ccagatgtta 22201 aaatatctcg agaatgaacc acggtttcca tggagttgat gttatatttg taatgcaaaa 22261 attgtatttg ttgcatctct tgcggtaggt ccattagttt tgagtacaat tgttcattaa 22321 tcagaaacgt tacgctatcc agtacaggta ctacattgtc taatatgggt tcaaaatagc 22381 aaaaatccat agtgggctgt gtcggcataa acccaaaaag tttggaaggt acaacaatgc 22441 tacagaaggg cagtgaatca tccaggacac aatgtacaat tttaccaggc gtgcaacctg 22501 gaccgtactg aggcaatcta attgtcccat ataaacattc agctttttta tcgccgtatt 22561 cgagatatat atccctagaa atgctacagg gggcgtatat tccggagaga ctaaacgtaa 22621 gcgatgcctt catattaatg ttactataat cgctttcttt tggagggtat gcaaacacat 22681 atatgctctc cactactgtt ctttgttcta attctaatga cttgtttgaa agtctccgat 22741 ggccgcactt tcccggaagt gttgacgatt atcgccgtat actatgtggt gtaaggaagt 22801 gtagcaattg gctacatgat atataaagtt cttttatctc tttcttagta aaacacttct 22861 ttcgagaact tctttcgcct catttatctt ggccgccatg tagggactcc ctcctctgtc 22921 tgggtggtta cgaaccatag ccttcctgtg cttttttttc agtaattttt catccaagtg 22981 attaatctct ctggcggaga tatccaagat gagcaaggct tcgggctctg tcattcgcgg 23041 tgcaaagcct ccctggtact ggtttaatct atttttcagt tcttcgtcta tcagtgagct 23101 tttgaactta agtgcatcgc ggtagcccgc cgtcgggttt tctatgcgaa tgttatttag 23161 ttttgcaata gttaaagggg acagggtctt gtagacggtc catgcattga gaccagactt 23221 gacacttaga gcaaccattg tcacgcccaa accaattatt ataggcaaaa ccatgctgga 23281 atatcctatt ctttgtggct atactgtgta ttgagtggat cctagcaacg aattcgtttg 23341 ttgttatttt tttctagatt gtatctccgt ttccgaaatt gttattcaca atgagcgttt 23401 acctcttgca ataacaataa tcagagaata agctacaaga cgaaaaatga cgttgagcgt 23461 ggcagtaatg ccataacgaa gatcaatagt gtatgggatg ttggatatgt cgtttccctg 23521 ccaaagaaaa agaaacacaa aaaagaaaaa gcaaaaaaaa acagtgctaa ggatttgata 23581 ttaaacgaag tcccaccatg gaggatcata tcccaataaa tttatgcata gaatggtacc 23641 attcacaact aatatagcct ctgctggttc ctttagtaac ctctttagta acctctttag 23701 tgaaatggtt cttgctggct ctattatttt cctaattcgg acgcgctggc tccgcgccgt 23761 gaggaaaaac agcaggctga caagggacta atttactgac actttcggct gacacttccg 23821 aaaaggtact caagctttta tgagtaagat gctggtttga tgctaagaat acgatttagt 23881 acttcctttt taatgtggct tgtttttttt ttattcgtcc ataacagtac aaatataaaa 23941 gcagaataca ttcttgccga cctaaaactt gtgtccttag actcaaactt tctgatggtt 24001 ttctttcagt agaatcaaca taaacaagca taatataaaa cactacaatg aataaactat 24061 tgttacatct agtacgagtc atttcgatac tcggcctagc aaacgctctc acacaaacgc 24121 aaccgatttt aaaagatatt caaataacag atagttatac caaaacaaaa gaatgtacgg 24181 atccagatca ttggttcata atagaagggc aactgtctat tccaaaggga agtcagcaaa 24241 atataacatt ccaagtacca gatgctttca gctcattccc tcaagaaccc ttcagcataa 24301 aacataattc taacagtgtt gccacgatat cacgcccaga taaatcgacg aacaatttca 24361 ccatttctat tccagaaaag agttcagaag atataactac tacatttaac ttccttgcac 24421 agcttacatc agatgctaaa tccaaagtta cagaaccaaa aagcatcgtt tacagtttct 24481 attcagaaaa tactatgttt aatgacgtta ttgattacgt cgctaaaaat acttctgcta 24541 taacaacaga tggtggtata tacaaaacta ataataccgc ctggtttacc gttgacttac 24601 caatgagaac gttcagaaat cccgtttatt tgacttctca gacatcttcc tcctcagatt 24661 acgtattcga tacttcgtta actaagtttg aggttgtcac tgccgttgat tcttttaacg 24721 aacctattaa tgctatccca tatacaactg ttcatgacta ctccacagaa gatgaaatta 24781 gatgtttatt taattctaca atcagcggtg ggctatactt ccgtgtgact tatttcacaa 24841 agaagctatc tacctcgtcc atatcaaata ctgtcgaatt aacatatccc gatgaaggta 24901 catctgtcag acttttagga aagagagata cttcaaccac cctagcctca gaattatatt 24961 ctgagtcagc tgctaacatt gattccacca ccagtgatga cacaactagc tctgatgctg 25021 ctataacacc aacatactca aattcaacgc tttcttctta tacttcgcaa tcatccgcta 25081 tccctgaagt tgcggttact gcatcattga gtagcgggat cctttcttct acagttgacg 25141 gtgctagcac ctcggcggac gcttccatgt ccgctgtctc tacggtttct tctagcagtg 25201 aacaagcttc ttcttcaagt atttctttat cggctccaag ttcttcaaac tcaaccttta 25261 ctactccttc atcttctctg tctgctactg aaacatatag tattatcagt tcagctagta 25321 tatctgtcac acaggcttcc tacattgata attctacaac taccgctgtt acccaatcta 25381 cttctactat agcagtttca tctgctgaaa aattgtcaag cactctatca tacaccagta 25441 acgtcacaat atcagtatca tcagctaccc aacatactac tactccttca tatgttagta 25501 actccactac actctcatcc tcatctgttc ttgaatctgt aattagctct ccatacctgg 25561 caaacactac tgtttcagga gcttcatctg caagtcaatc tactaatccg ccatatgtct 25621 ccaactccac aacatcatcc gcaactcaat tagccaccat tgctccgttc gcgattaaca 25681 taacaggaac aagtatttct tctagtatca ctaatacttc ttcagttagt tctactacgt 25741 ccagtttatc atccggccca tttgtttcaa acacaacggt tgcctctggg tcttatattc 25801 taaccactac tacagagtct gcacaactta ctgaaatagg gagtttgata ccaatctcga 25861 ctattactac tagtaccacc acttctggta ccgataaaac tggtagtaat aaggtggcct 25921 cttcaactga aatagcgcaa tctatcgtaa acaacagttc actttcggtg tcaacaatca 25981 acactaacgc tgcgacagca gctgctaatg ccagaaatgc tactttcact catgcaaccc 26041 attctggttc gcttcaaccc tcatatcata gcagctcact attatcgtcc acaattgaca 26101 ccaaggtaac tactgctact acaagcacca gtagagacgg tagttcgagt ttggctttca 26161 ccactgggct caatcaatcc gtagttaccg gtacagataa aagtgatacc tatagtgtaa 26221 tttcatccac agaatcagcc caggttacgg agtacgacag cttacttcca atttccaccc 26281 tgaagcctac agtcgttaca ggtacaagta gaaacagtac ctttagtatg gtgtcctcca 26341 ccaaattgac cgaagctact gcaacggata aaggtgatgc gtatagtgta atttcatcta 26401 cacagtcggc tcaagttact gaatatggaa gtatgcttcc aatttctacg ctggaaacac 26461 caacagtcat tatgagtacc gatgaaagcg gctattttac tttaactaca tgtactgagt 26521 ctgggcaagc tacagaatat ggtagtctga ttccaatttc cacactagat ggttcagtta 26581 tatatacatt tactggcgaa agtgtagtgg tgggttacag taccacagtg ggtgccgccc 26641 aatatgcaca acatacaagt ttagtcccag tatctaccat caagggttcc aaaacttctc 26701 tttcaaccga ggaaagcgta gtggctggct acagtactac agtgggtgcc gcccaatatg 26761 cacaacatac aagtttagtc ccggtatcta ccattaaggg ttccaaaact tctctttcaa 26821 ccgaggaaag cgtagtggct ggctacagta ccacagtaga ttctgcccaa tacgccgagc 26881 acacaaattt agttgccata gatacattga aaactagcac attccaaaaa gcaacagcaa 26941 ctgaggtttg tgtcacatgt accgcccttt cttcccctca ttctgcaact ttagatgcag 27001 gtactactat ttcattgcca acaagttcca gcacatctct atctacaata attacctggt 27061 attcctcatc tactattaag cctccttcaa tttctacata ctcgggcgcc gctggtcaat 27121 taaccatccg tattggcagt ttgttgctag ggttaatctc atttctgctg taagaactat 27181 tttatcaaat agaaagttat aaataaaaac taagagttct tttggtataa tgcataaata 27241 atttttttat ataatgtttg taattgtaat gataaatttt tatcatcttg gataattttc 27301 gtattatcgt aacattcatt cgttctagtt ttatgactaa tttgcatcga taatttctac 27361 agacgcccta tcggcttcta atgagggtct tggtgttact cttctcagta attgatcttc 27421 taaacatcta ctacttagca gtcggtcttg tacttgaggt cttacattaa aatataaacc 27481 tttttcatcc tttgtgtgtt tagacttttt gtacttgaag gtctcaatag gaagtatcca 27541 ctctaaccaa gatgtaccca ttatatcttg ccagttggcc attgaagaac ccaagtcaaa 27601 tatattctct aaatgctcat ttgttccata gctgtcattg aggatttcaa gatcccttcg 27661 ataccttctc attccgtgta cctcgatagt agtttggttt ttacaaacct gataaatgct 27721 gaaacaggta aatgctaaaa cagaaatgaa aacagcaacc gccaataggg ccacccctaa 27781 tagatgaaaa tctatcaatt cacggttgaa actaccggag ttaaaccacg tcccaagctc 27841 atagcaagta taaattagga ctaagaacgc gtataatgtt gtgtacatta agaattgaat 27901 aaaaaatttt tgattcctaa aaccagtgca ttcagcgaac caagggcaat gatgatccat 27961 tttcaatatg caaacatcgc atgatgaaca atgatgacag cgatcgggct tccaaacatg 28021 gcatacttgg cacacccgaa atcttccatc atgttttaag gtcaaacacc tttttgacat 28081 atactccgga ggaagttcaa gtccattttc cgctgccttt aaatcgtgga ctaacaaatc 28141 agggaaatct agaggagaac cgggacctct agcaataacc ttataataag tgtatagagc 28201 cactgccaat gtcggaacta ttgttagcgc gagaaaccac ctaggtattt gatgaatcct 28261 tgtcaatgtt atgtatgcag tccaaatata caaacatgtg gtcaaacacc tgggaaacag 28321 acttgtcaac gaaagcctgt cattcatttg cgaaaaagat tctatcgaat tccaagatcg 28381 gcttctttgt cttgtatttg gtacgactta gttatatagg tttttttttt tttcttggac 28441 gcaatcacat aaaagtgtaa tatatctcat tagacaaaat tggaaaagtt agataattag 28501 cgtaaaagcc ttcattaatg ataatagcgt gggaggtata agatgcgctt aataacgctg 28561 aagaatataa agtttcttat acattcaatg aaacaaggaa attttcaatt ttaaatttaa 28621 gttgaaatag cctttagcac ctaaaaataa aaaaatatta aaacaccaac atgttgttga 28681 acaagttttc cagagaattg accgaatatt taaatttcta tttaagagtc atataaattt 28741 attgaaaatc aagttgtata tctttagaaa agcacaaatc cctgtaaagc tgcaaattgt 28801 cgggcttaat gtgtataaca gcagaatagt catcaagagc aggtttataa tcatcgacat 28861 tgaggacttt ttcgtaaaat ttttcgtcaa cagacacatg atcaggagca ataagaagtg 28921 cttctgttgt catctcgtca ttctcatcgt cgccatcatc atcatcatcg tatacatcag 28981 tgaaatcttc tgcaatatca actagtggtt ctcctattac ttttctcatt ggtggaatct 29041 cactactttc atgactgata aaaattggat attttgaata cgaaaatgaa ttcattttct 29101 cttccaactt ttggcttctg tcagatatta tgtgcaggta atgttcatac aattctaatt 29161 cttgctttgg agatgtatct ctgtctaaat cggtagtctc aactacccta ccttcagcct 29221 tttctaaact cttactggat gtgatcatct ttagcttatt attcagccaa ctttgcttcc 29281 tagaagtgaa cggcgacata gccttgtctt gtttggacaa agcattatga tatcttcttg 29341 ttgaattcat attatatgca aagagatcgc gaatccaagt tactgatctt ggcagataat 29401 attcattcca gtaattgtca aaggcaccag gataacctct tacgtttttt ataattttct 29461 ctcttgtcac atcattacct gttgcaataa gttcttcatt aatcaattct tttacacttt 29521 tgatgttgta atcattccac caatgaatat agctcctttt aggcatatta agactataag 29581 cattatgcaa gtagaaatcg gtattcattt cccataaaga gggaaatcct tctctccagg 29641 agtagtgacc caggaataaa ttaatcgcat cttgcctttg tgcatcaacg aatgaattac 29701 tgtagaatct ttttatactt tcgatcatat cccttgaatg ggagctccac tgatttattt 29761 ttctatatgt ctccatggtg ttaaccaaat gcgaaccgcc atattgtaat gcaatagtat 29821 ctcccagatc atgaaacaat tcagttagta tgttgacgat atcagagtcg tactctaaat 29881 aactattatc gataattcct aaagatttga gctggcaacc aagtgctctc ttgccaatga 29941 cgaattgggc ggcgttggtc ctatcaagac agtcaataca attacttcga catattcctt 30001 cctggatctt tgtagaagca aagtctggac cattatgaaa tattcctgtc gtcgtgacag 30061 tgtttaccgc gtacttctct aagaattcaa taacaccttg accatcttgt ttagaagccc 30121 tgctcatatc ccaagaggtg taatctaatt tctttagtgt tggtaaaaat tcattcagat 30181 aatctataca ttgttcaaat tcccagagta acttagtttc tcttggcgtc ttttctttgg 30241 ttttaattaa gttcagtatt tgaatggttc cgccaccata tctttgaaac aagttatcaa 30301 aatgcaacgc agccggagaa aaaaatggat ctaccacatt gattcttata ggtggctttg 30361 tggttaaatt ggacgcatcc tgggtccagt ataaggggat tgagccacga tgctgtacaa 30421 aagaagtgta tcgatcacta tcaaaaaatc catttcccgg ttgatggaat ggagtcaaaa 30481 tcatatctgt tacaatctgt tcagtttcga cttcgttagc aacatgacct ttattgttaa 30541 caccacgctt tagaaagcgt gcaccagcaa aatggtggga tcttcttgcg attaaagtaa 30601 tatatatgga cttacccaaa actgaaacat taacctggtc aataaatcca tgtataatgc 30661 attggaacca atcaaaaaca gtgtcaatac aagcaaaaat aggagataat aaattgttat 30721 tccaaacaaa catttcgtta tagtcggtta tcccgcaagg tattgtaata tcacatcggt 30781 caaccgcttt taatttctct cgcaatatat tggtttgtaa agtatttgtg atatcgtagg 30841 tataactgaa ataaaaggtt tttgttaggt ctaaatcctt aaatatattc aatagccttg 30901 cctcatctga acttttttca ggttttttat agttgttcgt aataggaata atatcaatac 30961 catcaatgtg ataaatacca tgaccgccaa tcactgcaac ttggctatac ttggtaacca 31021 ttattaaata gtaccaacag gtgaatttaa tgaatcccag aagaccgtat cctgtaattt 31081 tcttatgtag accatcttca gttgcttctt ctaaacttgc tagtacattc atgatttcat 31141 ttctggtgaa gaagacatta tcctccaaca cagttaattc tccacggggt acagtaagat 31201 caatttctag aatacgaaac atggtttccc ttttattgct tccaacaata tacattcgat 31261 ctttggtttc gtataacgta tatttaccca ttacaaactt agaggtcttt ctctgcttag 31321 acccagatgt ggtaagtata cctccaccaa gggtatgctc cattgcatca ttgttcatcc 31381 ttgtcctgtt tcttttttgc tttgcgttac gttactacgt ttcaaaacta attaatttca 31441 aataatatca cagcatttac atttcaatag tgctcggcta agtagatgag gactatcgta 31501 aagagaccaa tagaagagct tgaaaacttt acaagaaata tatacatgta tatattatat 31561 atatatgttt aatgcaattg caagaggtat taacaaatca ggaggacaag taaatgaacg 31621 tgctgcaata aacccaaatg gcgtaacgag tgtagtgcgc cttagtgacc accgcaagat 31681 agtgccagta actagtgtac aagtgtggca aaatgcaaat gagcgttctg gtagtatgtg 31741 tccaatgttg tagtgtcaac tttgtctgcc gttctggtgg cttttgacag ttgattttcc 31801 aacgattatt attatgcgcg aaattaaaga aaaggaatct tgtatgatga taaaataaat 31861 agatcaaatt aaatcatcag tacagaccag aaaacaatta agtgtccttt tagaaatacg 31921 agagggtggt aaaatattga agaatggtaa atttcgattt gggccaagtt ggtgaagtat 31981 tccgtagaaa ggacaaagga gctatagtgt ccggagacaa cccagaagaa gaagaagacg 32041 tcgatgcttc tgagtttgaa gaggatgaag taaagcctgt gcgtacaaag aacagaagac 32101 ccaaagagga tgcattcact caacaaagat tagcggctat aaacccggtg ttaacgccga 32161 ggacagtttt gcctctttat ctgttaattg ctgttgtatt tgttattgta ggagggtgca 32221 tattagcaca gaactccaaa gtggatgaag taaccatata ttaccaggac tgtatgacta 32281 acgcaacctc atcatggagc gacatccctt ctgaacattg gcaatttgta tttcacaaat 32341 ataaaacata taatactgca ccacaatgga ggtttgtgga tgatgaatca gatgacttca 32401 caaaacaaag aggtacatgc caaatcaggt tcactactcc aagtgatatg aaaaataacg 32461 tatatttgaa ttatgtgctg gaaaaatttg ctgccaatca cagaagatat gtactatctt 32521 ttagcgaaga tcagatacgt ggggaggacg cctcttatga gacggtgcat gatgcaaccg 32581 gtataaattg taagccacta tctaagaacg ccgatggtaa aatatactat ccatgtggcc 32641 taattgcgaa ctcaatgttc aacgacacgt tccccctgca gttaacaaat gtaggggata 32701 cgtctaacaa ctattcattg acaaataaag gaatcaattg ggaatctgat aaaaaaaggt 32761 acaaaaaaac caaatacaat tatacacaga tagcacctcc accatattgg gaaaagatgt 32821 atccagatgg atacaacgag acgaatattc ctgatattca ggattgggaa gagttccaaa 32881 actggatgag gccaggtgct tttgataaaa ttacaaaact gatcagaatc aataaaaacg 32941 atactttgcc agcgggtgaa taccagttgg atatcggtct gcattggcca gtattggagt 33001 ttaatggtaa gaagggaatc tacttgactc acggttctca ccttggcggt agaaatccat 33061 ttttaggtat agtttacctg attggaggct gtatttgtgc tgccatggca ttgatattat 33121 taacgttttg gctcttcggc ggtagaaaga ttgctgatgc atcaagtttg tcatggaata 33181 tgaaatagaa aaggagtgat ggttttcttt atttttaacc ctgtaaaatt tttttatttt 33241 tttattttta ctcttatata tgtatatgtt tgtgtttatt tctgaataaa aatttataag 33301 aaccaaatta aaaccgttaa tagcccaccc aaaattgaag taaacgaact catacctaga 33361 tgctgggcct cattatgcga aactgttttc tttattgcag atttaataac gcctacagta 33421 ccggttaaag tacccatccc aatagacccc acggagggag aagcgactgt tacgtactgg 33481 gaggagaaac gctggacaaa agtagtttgc acagtgatag tgttgccctg tctaacaaca 33541 gtgacccaca tggacgttgg cgcacgtgtg gttgtgtaag tggaggttgt accttcagtg 33601 atggtaatgt atgagtcaat agatagacta gtgacagcag acacaggagg ttctgtgaag 33661 tctgtggagg ggtctggcct ggtgcctgtt tcagctactg cgctccctgt cgatgtggtc 33721 gtctttacac tggaggatga accagacgaa gatacagacg aggacacaga cgaggaggcg 33781 gatgaagtag cactggtgct agaatgtgtg aacgtttgag tcaatgtaac tgtggtaccc 33841 aaatcgtttg tcgtggtaac tgtagataaa tacagtcccg aagacaacga tgaagttgcg 33901 gtaggaacag tggtggttgt cttaccagta gatgaggtag aagtcgtcgt ggttggtagc 33961 atagtggctc tgttgactgt ctgagtaaga gtgacggtgg ttccgacatc gttagtggta 34021 gtgaataccg tagtgaagaa acctgtttga gcggtagttg tagcagcagc agcagcggtg 34081 gcagggtccc atattgtggt ctccgtaacc agggcccctg cgacatttgt taccactgta 34141 acctgagttg tcacagctgc catgaccgca gctgaccaca acgacaaaga aagtagcagc 34201 gtagcgaatg aatgtaatag cgtgcgacgc atcatttttt ttttgattgt cttgcagaag 34261 ttgaagaggt ctttactgta gcatatacaa gtgcttaatt cttgattttt attttctttt 34321 tttcataata cacgttatag aaaaagcccc attctcagtt tatgaaaaaa cgcgatatca 34381 ccatacacgc tgaggtaggg ggatacaagg tgaagaatgt acgcaataag gcgaagtata 34441 tggcacaatt gagcagtaaa agtgttaaaa tatagtgata tatatatata aaatacgaga 34501 gtaccaacta ttatgatctt ttaatgccct ctttccgttg agatattcat aatagtaacc 34561 gtcacggaac tgtcgcttta tacggtgagg ggattattta gttcctaatt tatattagat 34621 aaagaagata ataaacatga gggatgctgt aaatgaaagt gaaataactg ctagctagaa 34681 gagcggtaag cagcaatggc caaaaataac cacatttctg ccagtggtaa cagtacctct 34741 ggagaccatc gtcttaaaga ggaggttctg accccaacta catctgcctc gactcctcat 34801 agaatattta gcgtggacga tgatccaaag gagatccaaa acgatatcag gtatcttgag 34861 ggtctgcatg aagggttgaa gttcgccctg catgccaata aatccaagcg atctgtaagc 34921 tcgcaatcac caatcgtaca tagcagcaac aacacgctgc accaccacga gcaccaacaa 34981 cacttgccgc ccacactaga gtcgctatcc tccaagtcgc actctgtgcc agacttaaat 35041 acagctactc ccagctctcc gaaacgaatg cattcatcta tccgggaatt acctcatgat 35101 gacaatgatg acgaggacgc caatgatgac agtcggttca ttatacacga ctcgcacggc 35161 catgatttac ttatagacga gatcaattgc cagtcgcctt cacacttgga aaacaatgac 35221 caggcgtcta atgcttcgtc cacagagtca ttcactttac gagaaagaca ggacgccatc 35281 aacgagaccc accccttcgg tatcaggata tggaagcctg ctttatataa gaaacaccgt 35341 tcagttcaaa gaaccgcggc gcaagacatt cacgagactc agttgaagac tattacctgg 35401 gaggtgactt gttccaatgt gctatggttt attttgttcg gtttccccat tgcgatactc 35461 ttctactcgg cggctattgt ggtattttta ctaggcggcg gaggactggt aacgaactct 35521 gcgaaggagt actccaagtg tctgtataaa ctcgccaatt atttcctttg gccttttggc 35581 aaaatggtat acttgttgca ggacgagcaa tatttacaag aagataagga tgaaggtatt 35641 agtatgcagc aattctacaa ttgggtgact tcatactcca acaggctggt cttccaccag 35701 tctcaggcca agtttcagca aagagaggac catccggccc ctgcaacgga atcttcgtct 35761 ttgatgccgc ccgctaacac aacagcaaca ccgcttaact cgaaccatcc atcatataat 35821 tctattagac acgaaattcc gcacgcagcg gctcaaagac ggtactttgg gagaggaaaa 35881 tggagctggg gtcgtgttct tttctataca atcttccatc tcgtcttgca acccatcctt 35941 gccgtcttat ctctttgcct ctggctcctg gtgtttacca ttcccatgag taatgttctt 36001 tggcaaatta tgtatcattg cagaagacat ccgcttgcat taggcttcaa atatgtcgag 36061 aactcctccc aatcgcacga aaatgaaata acccagcagc aattgaacaa aaatatcctc 36121 ttatgtacgt tccgtgccgc tggctggcat tactacaagt acacagttga tggtacaaat 36181 gttattgttg tgaatttaat atccatcgtt ttctttacaa tttttgactt ttatgttttg 36241 aaaaatttcc tgcattggaa aacgtggttc acatacgaat cctcaatatt cattctttgt 36301 ttgacatcca ccatcccact agcattttac attggacaag cagtcgcatc gatctctgct 36361 caaacttcca tgggtgtcgg tgctgtcatt aatgcatttt tctcgaccat tgtggaaatt 36421 ttcttgtact gcgttgcatt gcaacaaaaa aagggtcttc tagtggaagg atccatgatt 36481 ggttccattc taggtgccgt tctattatta ccaggtctgt ccatgtgcgg tggtgctcta 36541 aataggaaaa cacaaagata caaccctgct agcgctggtg tctcttccgc attgttaata 36601 ttttccatga ttgtaatgtt tgtccccacc gttttatacg agatatatgg cggctactcg 36661 gtaaactgtg cagacggtgc taacgaccgt gactgtactt tctcgcatcc tcccctgaag 36721 ttcaaccgtt tattcactca tgttattcaa cctatgtcca tatcttgtgc cattgttctc 36781 ttctgtgctt atatcattgg cttgtggttc acccttagaa cacatgcaaa gatgatttgg 36841 caattgccta ttgcggaccc aacctcgacc gcaccagaac aacaggaaca aaattctcac 36901 gatgcaccca attggtcaag aagcaagtct acttgtattt tacttatgtc tacgctcctg 36961 tacgcaataa ttgcagaaat ccttgtttcc tgtgttgatg ctgtcctaga agatattccc 37021 tccttgaatc caaagtttct aggtctcacc atttttgctc tgatccccaa tacgacagag 37081 tttttgaatg ccatttcatt tgccatccat ggtaatgtag cgttatcaat ggaaatcggt 37141 agtgcttatg ctttacaggt ttgtctttta caaatcccat ccttagtcat ttattccatt 37201 ttctatacgt ggaatgttaa aaagtcgatg attaatatca gaacacagat gttcccatta 37261 gtctttcccc gttgggacat atttggtgct atgacgagtg ttttcatgtt cacctatttg 37321 tatgctgagg gtaaaagtaa ctatttcaag ggttccatgt tgatattact atatatcatt 37381 attgttgtag gattctactt ccagggagct ctttcggagt agaaagcaac tgtccccgct 37441 tttcacctgg atacctacca atttttcttt ttcttatatc tttgtattgt ttgtctttct 37501 tattactttt tattctatat agtctttagt taattaatta cccgcaacga tcattaacac 37561 ctcttaaatt gatctactca caattgggtt gttcttatac ttagagaggt gcgttcctcg 37621 aaataactcg aatcaagccc acacctgctc ccttttttat ttctccgtca attgcactgt 37681 agaatccttt tctggtctca tgttgtggaa agtttctaag atgttcttgg gtggcttggt 37741 agcgctaaca acaatatcgg ttgcgaccct ttatcactac caaaatcgcc tagtctaccc 37801 atcatgggct caaggcgcca ggaatcatgt tgacactcct gattcccgtg gaatccctta 37861 tgaaaagcta accctaatta cacaagacca cattaaactc gaggcatggg atatcaagaa 37921 tgaaaactca acaagtactg tgttgatctt atgtcccaat gccggtaata ttggatactt 37981 tatactaata attgacattt tctatcgtca gtttggaatg agtgtattta tttattcgta 38041 tcgtggttat ggtaactcag aaggttcacc cagcgaaaag ggtttgaaat tggacgctga 38101 ttgtgtcata tcgcatttgt caacggattc tttccattca aagagaaaac tagtattgta 38161 tggtagatct ctaggtggtg ctaatgctct ttacattgct tcaaaatttc gggatctatg 38221 cgatggcgtt atactggaga atacattttt gagtattcga aaagttatcc catatatttt 38281 cccccttttg aaacgcttta cgcttttatg tcacgaaatc tggaattcag aaggccttat 38341 gggaagctgt agttcagaga cgccattctt gtttttaagt ggattaaaag atgaaatcgt 38401 tccacccttc cacatgagga aactgtacga aacatgtcct agttcgaaca aaaagatttt 38461 cgaatttcca cttggttcac acaatgatac tattattcaa gatgggtact gggatataat 38521 aagagatttt ctaatagaga agggttttat ctaaaagtaa taatcaaaat atttgataga 38581 tttatttact ttactgtatg taaagaaaat gtggtcagtc ctcacggcca cttagttact 38641 gatggttatt tattatggaa aaaaaaactg cactttgcta cttcttctat ttatattatg 38701 taatatctac tccggttcaa atattttatt gatctcttgc tcattctttt tcctcgtttc 38761 aggaactagt atccaactga atattatcaa cgctaatagg caagcagcaa atatgtatcc 38821 tagtttgaaa tcaattttgg atacaatcat tggtgttaaa agtgatatta agaaattgaa 38881 catccaattg ataaatgtgc aaatagccat tgatatggcc ctcgttctta gagggaacaa 38941 ttcggacact agtacaaatg taactgggcc caatgttatt gcaaaccaaa aaataaaaca 39001 acaagtcacg ataattaaaa caatatttga gaagtccgtt tctcttccaa atgtccccac 39061 agtagcatat gtcatcatat aaaataataa atttgttgaa ccatataata aacatgtctt 39121 gtggccccat ttctccacgt aatatatgcc taatatcgta gaaaggaagt taacacttga 39181 cagtatgatt gaagtaatat aaggatcctt aatcccgaca cctttgaaaa cagacgttcc 39241 gtaataaaag aaataattta ttccggacag ctgttgaaat gccattatca tcataccaat 39301 aatcagtctc aaccataact ttggctttcc cataataaat tcaaatgtgt ttcttttaac 39361 taagctttgc ttttttgatt cgttgttagt ttcctcatta ttatagttat tttccagcaa 39421 atcatcgatg aattcaatta ccatgctatc cgtcgcaggg atgccattca tcctcgcaaa 39481 agagtattta gcagagggca catcattttt gatttttgcc aagtactgtg gagattcagg 39541 aacgtaaaca agtgacattc caattataat tgcccaaatg tatcccaaga acaatggcaa 39601 ttgccaggct atattttgtg taggatcttt ataacatctt tcgcatatga aatttaaaat 39661 gtttcccatt agtatgccaa atgttacaat caattgatac gtagatacca tggagcctct 39721 gatttttagt ggagaattct cggagagaaa cattggcacc aagacagtgg ttactcccac 39781 accgattccc gttacggctc ttcccaatgt caaaaaatac caccttccat aggagagaat 39841 ttgaatggtt ataccgatgc agtacactac taaggcaaac catataccac ctttcctacc 39901 aatccaatca ccgatttttg acagagttaa agcccctacg ccacaactga tgttaaaaat 39961 actgataatt aggcctattt gcagatcagt aagtttctta gtagatacaa aaattgtttc 40021 atcgtcatgg ataatattag ttgtgccaaa tttttcttga aagctaacca tatttgtcat 40081 tccaccgatg gttccaatgt cccatccaaa aataaagcca ccaagcgaga ttaccaagca 40141 caataaaacg ggaatatgca gactcgcatt gtgactaatc tttgctgctt ggccttctat 40201 attttcttct ttatcatcta gatacttaat ggttacatta taatcccttc ccctgcctgc 40261 atcaagctca ttattgtgaa aatgagagat gtatcccgag ctatgttgat acggaatctg 40321 agcagtcatt tctagcaata attgaagtac tttacttcct aagaatacgt taacaaattc 40381 tttgttagta tttctaatta aaagtggtta attgttctgt taaacagtat tcaatgttgc 40441 tatttgaatt tgtgtcatca ttagaattac tgacattttt attttctatt tttttttcta 40501 ttttttttcc tcttcttttg agggccgacg tatcgatttg tcaagggaag tataattaaa 40561 gaaagcactg atatacaggt tgctgggtag atattaagaa gctcaacata gacacgttat 40621 ggacgggcat aatcagaacc agtaccagaa tcagaatcaa attcagcagt cacaacaacc 40681 acctctgaag aaatatgtga cacagagacg atcggtagac gtgagttctc cgtatattaa 40741 cctatattac aacagacgac atggattacc gaacctagtg gtagagccag aaacttcata 40801 cacaatagat ataatgccgc ctaatgccta cagaggtcga gatcgagtca taaatttgcc 40861 cagcaaattt acgcatttaa gctcgaataa agtgaaacat gtgatacccg ccatccaatg 40921 gaccccagaa ggcagaagac ttgtagtagc aacttatagc ggagaatttt ctctatggaa 40981 cgcatcttcg tttacgtttg aaaccctcat gcaagcacat gattcggctg tgactacaat 41041 gaaatattct cacgacagtg attggatgat tagtggggac gcagatggaa tgattaagat 41101 atggcaacca aactttagta tggttaaaga aattgatgct gcacacacgg aaagtattag 41161 ggatatggca ttcagtagta acgactcgaa atttgttacc tgttcagatg ataatatctt 41221 gaagatttgg aacttcagca atggcaaaca agaaagagta ttatcggggc accactggga 41281 cgtgaaaagt tgtgattggc atcccgagat ggggttaatt gcctccgcat ctaaggacaa 41341 tttagtaaaa ctgtgggatc cgcgttccgg aaactgcata tcatcaattc tgaagttcaa 41401 acatactgtc ttgaagacgc gatttcaacc caccaaggga aatctattaa tggcgatttc 41461 aaaagataaa tcgtgtcgtg tgttcgacat tagatacagt atgaaggaac taatgtgtgt 41521 aagagatgaa acggattata tgacactaga atggcaccca ataaatgaat ctatgttcac 41581 tctggcgtgc tatgacggct cgctaaagca ttttgatctt ttacaaaatc taaacgaacc 41641 tattttgact attccatacg cccatgataa gtgtatcacc tcgttatcat ataatccagt 41701 aggacatata tttgccacag cagctaagga tagaaccata agattttgga ctagagcgag 41761 gccaattgat cctaatgcat atgatgatcc aacttataac aataagaaga taaatggatg 41821 gttttttggc atcaataacg acatcaatgc tgtgagagag aagagtgaat tcggtgcggc 41881 cccgccacca ccagctacac ttgaaccaca tgcgttacca aacatgaatg gattcatcaa 41941 caagaaaccg cgtcaagaaa tcccaggcat cgattcaaac atcaagagtt ccacattgcc 42001 aggtttaagc atataaaagt gcgctttgac gagattttag gatacataaa taaaaagact 42061 atataacata ttatttgtga taatatctct catttctggg gaatgtaccc cacaggcacc 42121 actgtttact tttgtcgctg atatcttcat agaatttttc tttattcttt ggggtattct 42181 tctcggtgta atattcaatg aaaaataaat atcgccagtt tctatcatgt tcgtccaaat 42241 ggaatggtct agagtttata gaacacatgt tgagtgaatg gatttttagt atgttcaaaa 42301 catctaccaa agaaccaggg tcatcttgac gagtagtaaa ggtgagtagg ttaacccgta 42361 gtaatccagt gtcttctact tcattgtcgc ctgcgttctc ccttctcttc aatactaaaa 42421 atcttgttgt atttcctagc ttatcattta tcgaatgttc aatgatgtac gccttatgca 42481 attgggcagc tgtttcacta gcaatggcta aatgcagaat gttgtcgcaa tcggccgttg 42541 atgaccgaat gcattggttc actgattcag atgtggaaga acaatccaat cttataaagg 42601 tgacctgcgg aaatttttct gccatggacc ttaagtaaca ttcaacctgg ccccatactt 42661 gcggatgtga gtgtattatg acttcttcaa aatttccaag ggatgcaata ccatttggta 42721 gttggattgg gctgattaga caatgggtaa tgggtacata ttgctccgct ataacttcta 42781 tatctggtgt aattctatta gtatctgctg gagcaggtaa ggatagggct tttttgatca 42841 tcctatcacg caagagatca taggaaaaaa ctacttgtcc attggtggaa ttttccaacg 42901 gtaccactga ataatctata ctagtgtcgt tctccaattg gttaaaacat tgggggatag 42961 aggctgctgg gaggtactca acatcagatg ttgattgaaa ttgttgtaat gcagcttgat 43021 gggaatacgt acctttggga cccagaaaaa gaaccctcaa agtcttgctg gccataattg 43081 aaggatgaat gcggaaatat aatgaagttg cttttcgtac ttttttagcc tgttctttct 43141 gcgtattata ttcatctact aaaattttta ttttcatttt tcattatgaa aatacaagag 43201 tcatgctgat aactgtgtaa agaaactgta cgcttgtcgc agatgatgta gtacgtattt 43261 tatttacagg tgtcattaat atatatatat atatatatat acgtatacgg aagtaattct 43321 tcgttaattt tccatggact gtgatagcga aatcaatttc tcgacggtga atcccggaga 43381 ggccttagag aaatctctta acaactgcac tctctgttta gcaactggag tttcttcacc 43441 cattgcacca taaaaccttt gcacgtttag caataacagc tgtgcatcct gtacattcac 43501 gtttgtatcc ggttcaacat ggccattcat aaaaacaatt cccttatcct tgaccaaatc 43561 agaatggaac tgcaaggtag tatgtggcct tgcaaattcc tggtgtagtt tgtattctgc 43621 tagggaagtc atcatacaat gtgttgtttg gggtccgaca aactgccatt ggatgtagtg 43681 tagttccatt ccctgttctt cgttcggttt tgcatcctca gattgaactt gtctaggaag 43741 tggcaacacg aatatagggt tattcctggc atttgccatc atcttatcat aaacggagac 43801 aggaatcaca gcgcataatg tattatcttt ttgtgcccat cttgctctcc aaagaaactc 43861 tacttcctgt ttcgataagt ccttcagttt tccaacatcc aaaaaagagt ccaatgtttt 43921 gaagggaact ttaggagcac ttggatcgag aggacttctt gatttcgtca tcaaatgctt 43981 ggagttgtta ttttccattt gagttttttg ttggtaatcc tctagttctt tcagggggtc 44041 gattttatta aattcccgct tcttagactc tatagtctct ttcaaatgat ttttcaactc 44101 ttctatgctg ttaaaacctt gtttttgagc ctcttccaaa agtttctttc tatacttctg 44161 ctctgggctg gaagaataaa aacgaaaaac aggaactgtt ccaattgcct tgttaaaaat 44221 gggcgacagc tgattagaaa tatggattct agtgccgatt tttctggtta gtctccacat 44281 agttattctt aaatctcttt tgttctctat tttcaagtct tgataagttc ttcacatcct 44341 tcgattacgg cgtcaaaata agcgttattt ccattcgggt gagttgaacc attgataaca 44401 acatggttta acgatacttt gaaaggttta ggcggagcca accataatgg atgaatcggt 44461 ggatcctgtg gagctgcttc tacgactact gatacggcac aaacctcatc tgaaaccata 44521 tgcctacaga caagatagct ggcaaagggt gctcgatgag tacaacagac agactgggtc 44581 aagatataga caatcaagga cgttaaaaac caaatttcgt cgactgaagg acctcttcag 44641 cgcagatcga gcccaattct ctccttccca gttgaagctg atgggagcac tcttggacga 44701 agcaccagaa catccaagac caagaactaa attcggaaat gaatcatctt catccttatc 44761 atcatcttct ttcattaaaa gtcatccggg gcctgatccg tttcaacaat tatcatccgc 44821 tgaacatccg aataaccaca gctccgacga tgagcattca ggctcacaac cgctgcccct 44881 ggattcaata acgattggaa ttccgcctac tcttcacaca atccccatga ttctgtctaa 44941 ggataacgac gtcgggaaag tcatcaaaag ccctaagata aacaagggta caaataggtt 45001 cagcgagaca gtactgcctc cacaaatggc tgctgagcaa tcgtggtcgg actctaatat 45061 ggaattggaa atatgtctag attatcttca caacgaactc gaggtgataa agaaaaggca 45121 agaagatttt gagtgtaaag ttttaaacaa gctcaacata attgaggctc tcctttcaca 45181 gatgagacca cccagccaag gagataaaat ataaaaactt ctattagata tgcttgattc 45241 atgtccatat gtatctattt atacaaacat tacgtaatat acacagatta tacatgaaag 45301 gtgctcttca tatttggctt cttgcttcca ctagcctatc ccaaccagga gagtcatccc 45361 atctgccttt gcctttactc attagagctt tgatagtaga tctacatttg tatttccagt 45421 ctttgcaaac cagactgcct ggcccatatt taccttccat ttcaccaagt gattcatagg 45481 cagccaccaa atcttcacaa gcatccactg tatcattcca aaccttttct tcaacttcta 45541 aatcaggatt gtgagaaatg gccctataag ccttctcgtg gcattctagg gcggcccatg 45601 gtctcttcct ccaaagttct actcttgcga ccagtcgcca acatcttgca ctggttgtaa 45661 ttacctgagg taaagtgtta cagataaact cagtacagct cttttgaaaa taagataatt 45721 gctgcggctc ctctggatat tcactagtca ctaatagttc tactagtttt tcaataattg 45781 gtaagtcgat ggaaccttcg ccagatttgt ccctcctaat actgactaat tgtttacatg 45841 cagttaagac atcctcccac tcattcaact taacagcaac aagcatgtaa ttctcccaaa 45901 ttttccagtt cttttgagcg tcacatgaaa tggctctttt caaacaacta taagcttctt 45961 tcaatttatc cattttcgta tatgcagcgc tcaaatttga ccatgaaaga gcatgataag 46021 ggtctaatga aacacatctg gtaaatgcct ccgcagctat ctgcatttta ccacattgta 46081 atccaacgca accataaaaa taccacgttt caaagcttaa tgggtattgc cttaacgagt 46141 catttaaatg tttcaaggta gcagagtaat ttggttgtgc tccagacttt ggaggaggat 46201 taaagtaata ctttgcaagg gaattttttg cgttgacgta ttttccaatc tcccaacttt 46261 tttcccatag ggatggatcc tgttttatat cacccaaaat ggagtaagcc ctggcatccg 46321 aatcattttc atttattctt tgaagaagga tttcttctgc ctttttttca tctccaacag 46381 cggcataaca taatgcagtc tcgcatgcca taccaagtct ttcataaatt tccacagcgg 46441 acttcaaaat acccagcgac atatattttt cagctaaggt ggcatccaat tgccacctag 46501 ggatgaacgg cagctggtgg atgtatgaca gcctgctagc aacattgatt tcgcttgaac 46561 ttggaaccaa tttactctta atcttcaaat ccaattcttc tacgagggat tgcatttgta 46621 aaagtcctct ttcaatagtt ttagcctttg ttgtctcaat aattgacctt tcccataatg 46681 atcgggcgaa aatagaccaa tttttgtcac cgttttgata taatattcta gaaagcaaag 46741 cagtaagttc ttcttccaca agaggatcct tggccggagt tgtgttcttt atggtgtaaa 46801 gacgtaacag caactggatg ttgtcgtaat cagatagggt aggttgatcg ttagggttca 46861 aatccagcaa caactttgga atattttctt gacgtagtgc caatggcaat agtttatctt 46921 cttcataacc ttcatttagg tctacctttt gtcttttact ataaatttgc tcgtctagag 46981 gttcatcagc aatggactca aaatgaggct tctccaataa tagatcggac tctaaagcaa 47041 atgtttctgg tgtagcagat gtcgttctca aagcaaaatt ttgaaatgtg aaggatttgg 47101 caagaatgat caaaccggca tgagcctttt gctgatattt agttctagta gcgcgtgcac 47161 ccgtcattac aaattcaaaa tttgttatct ttttcgctct ggtcaaggat ggcaggcaca 47221 aatgttctgt gttgatggcc aatgaacatt tgacattctc tagatagtac attgcacaaa 47281 gttctctttt gaaatcttcg tgaatactct ccggtaattc cttagttatc gcatatgcaa 47341 ggtcagcaga ctgatatatt gcagatgcaa cactagcttg gaacccagaa ggttctggaa 47401 tcagtgacaa ttgcgtcaaa agagctcttg cccaccacca ataagctaca gctaataatc 47461 caggagtaga ctcagcagag ataataggta gcggaatttc ttgatccggg gtaacatcaa 47521 ataagctttt ttggccggtt atcctttcaa gtaataatag tgataaaacc aaatacaatg 47581 gatcatccat aaattcgtag gcaggctggc ccataatggc taatgagcgg gaaagggctg 47641 tattaactgc tcctatttca attccagttt tgccaaacaa acctgagatt gctttcaacc 47701 tagctgctgg gccggtgtag ttattttgaa taaaggtctg taagagggca atagccaaaa 47761 atagcatctc attttcttgg cccattttga aaacctcaac gttaagaaag tcatttagag 47821 cagcaataac actagatgtg gatatttctc ccgaaatact aatttttccc ttaaatttgt 47881 ccacaaattg ctgtactagc tggtatgatt caccactgat gatatgttca gcctttttca 47941 catatgtctg gtcgaaagaa ccacttttca gagattctac ttctgcagac agcaataatt 48001 ttgcatgcaa taacgtctcc ataattttgc aaccactagt ttactttttg cctggtctga 48061 tagcttcttt ttagcaattc ctttggcctc gatgagcttc cattttcaat tttcatcttt 48121 tttttcacga tgcgaagttt cttagataat tatcgccata tacgaaacgc gttaggaaac 48181 gcgttctttc ctttataata agcaatatta tatcaactta aggtggaagt aatgtggcaa 48241 aatcgatagc gactatctag aacaggctag tttaagcata tacataatgg caagtatgta 48301 ttagtgctag gaattggagg atttgctctt ttctgcatca ttttttttat ttttattggc 48361 gaatgttaaa attactaaca atggatggga ttccaataca gcctatcaac catataacga 48421 atattcatca gtaacgggcg gtggctttga gaactctgag tcccgcccag gtagtgggga 48481 gtcggaaact aacactagag ttaacacctt gacacctgtg acgatcaaac aaattctaga 48541 gtccaaacag gatattcagg acggcccctt cgtttcgcat aaccaagaac ttcatcacgt 48601 ttgttttgta ggtgtggtga gaaacattac agaccatact gcaaatattt ttttaactat 48661 tgaggatgga actggtcaaa tagaagtgag aaaatggagc gaagatgcaa atgacttggc 48721 tgccggtaac gatgactctt ctggtaaagg ttatggttcg caagtcgccc aacaatttga 48781 aattggcggt tacgtaaaag tttttggtgc tttgaaagag tttggtggta agaaaaatat 48841 acagtatgcg gtgattaagc ccatagattc attcaatgaa gtgttgacgc atcacttgga 48901 agtcatcaaa tgtcattcca tagccagtgg aatgatgaaa caacctttgg agagtgcatc 48961 caacaacaat gggcaatcat tatttgtcaa ggatgataac gatacatctt ccggctccag 49021 tccgttacaa agaattctag aattttgtaa gaagcaatgt gagggcaaag acgctaattc 49081 attcgctgtt cccattccat tgatctcgca atccttgaat ttggatgaaa ctaccgtcag 49141 aaactgctgt acgaccttga ctgaccaggg ttttatctac ccaacttttg atgacaataa 49201 cttctttgcc ctatgaaaat atatagatta tttttttagc atttcttagt attcgtttgt 49261 gtatttctac taggtaagta ccaaaatttg ccggaaatag agtggaaaat ggaacccgtt 49321 ccaagaaggg gtaagatgca tgaatattaa gttggttgca taaatatgct atataaagtc 49381 cactacaaaa agtcatttat ttttgcccgt aagaataaag aacgaatccg tccttatctc 49441 tgacttcaat gggaacattt acacgcagta cgggcttcaa taatagttcc cagtcgtatc 49501 tggttctagg tgtacataat gaaaaatgtc tcagcattct tattttgaca gctttgaatt 49561 ttgacaaatt tctcaggaaa caccagaggt taatatttgg aatatcttta aaattctctg 49621 gatcttggaa atcattgaaa aaattttcca atgtcacatt ttgtaagaac tcctccacat 49681 ctaaatctct atattcgatg gttcggttct tcaatttgat taaactatct cttaggcaac 49741 gccttacaga gttgttccaa tagtaagtgt ggtgaatgtc tgattcaggg ctcattactg 49801 tacttaaatt tggaactgca ttagcatttg gtatgttatc tcttatggaa ttattttcgt 49861 aaccgattaa tgtttcttga tcgttctcgt cgccaacatc ctcatctgtc tcatcaacac 49921 tagtaattgt tcttgctaga tgttcccaaa acgatagagg ggataaagga tacacattgg 49981 taaaggggat attgattacg ttaatagaaa tatttttact tggaagtctc tcccaaagta 50041 agcggtaata atggtagaaa gaatgaaatt cagggattct ttgtcgttga aaattttgta 50101 gctgtgccgc agttaacatg gcgggctttt tgttattgtc tggtgatggg ttatttgaaa 50161 catcatttcc tgtagttcta gaaatatagt tcagatttaa ggacaataca actgaagatg 50221 tcggcggagg agtaattatc ttcgaatctg atggcgcttc aaataatgtt tctgtcatgg 50281 aattgcagtc atcaaaatca tcttctgtat ccaaacttcg ctgttggaaa taatatgatt 50341 cgccgactac ctgttcgtta gtgaaacatt tgctattaca atcaattgtt agattggata 50401 acgatgggaa acaactgcat aacaataagt cgaatttact gttaatcttc agtaaggata 50461 gatgtttgac cattttaaag taagagtgaa acaaacgtaa tattccattt ccaggaacta 50521 catcacatga atctaaagta agtgcagtga taggagactg taaactgtac agttcattat 50581 cttcgttctt tagaaatagt ggtaagaatt ccattggagt atctagcgat tcggtgtcta 50641 tcgttacatt ttctagttta agttcattaa ttatgccgaa acagcagaat aaactcggtc 50701 ttagtacgag cttttggtga tggcgttgac gattaaaggt tctttgtctt ttattattag 50761 ctttgatttc cagtattttc aaccttggca gagaataata cttggattcg tattctttga 50821 caaatttttt ggatagttgg aaagtcctca aatcttcgtt tgtgatggat tgctggccct 50881 tgattatttt cttgaaaaaa tctctagatc catcgttgaa tacagagtac cataaaggaa 50941 ttttaaaatt cggttccaca tcactcagaa tcactctggt caggttcggt agatagtcta 51001 taatatcaag cattagctca atataagtat aatggaagta gttgctttcc aatttatcaa 51061 gcagtttgat tcgttctgaa gttatgatgg gagtctcatc gtttagtctg atgttattca 51121 gtttttttac gtctttatca tacgaatcga gtttataaga tccagcaata atagaatctt 51181 ggccactctt attatagaac ttactgtatt ttaacaacga gtcttgggac tgaggatttt 51241 tgaattcgat ggatcttacg aggaaccttg cattttgtga tctagattgt gtgctacaat 51301 caccgctgtg tgtgacaatg ttcgacgtgt ggaactcgga gtgtatcaaa gcattgaact 51361 ttaacaacga aagttttgag tccaaaataa cgttttggaa aaggaactca ttcgtaatca 51421 aattgtagaa cctcgaattg acttggcata gtgttactaa tgtattgaag tccaaagttc 51481 gcagtattaa cagtagaact tttgttggca aacacatgag ggacgattta tcgttgaagc 51541 gtagtgatct cgatttgata tcatggctcg tactatgtag aaggcttttg gcatcagcac 51601 agccctcttc ctcttcttct tcctccttcg cagcactgga gaccagcgag aaatattttg 51661 atctaccaaa caattgcaac cgtttcatga ttcggttggt ttgaacgttt gaaaatgcgg 51721 ttcaactttt catatctagc agtggctcat ctttatgtac tctagtccta aatcttctgc 51781 tggttatcgc aaaaaaatat gtgatgtgcg ggtttttggc agtaatcatg actcagtctc 51841 tggaaaaacg tgctatttaa cggttatata tctatctatg tacatgcctg tgcatgagct 51901 cttcattcat ttctgggaag ggtgagggag ctgggatgca ttttctgagt tgttcttggc 51961 atattttccc aggacgtcct ttagcgaatc tgggatgtct tcaaactcca agtcgcccac 52021 gtcttggcta acttgttctc cgttagcttt cattaactgt tccacggtaa catgatgatc 52081 atggaatatt ttcagatggt ctgctatcaa atgtctcact ttgcagtgcg gacaagagat 52141 caagacagta cctttctcgt acgcctgctt ggacattgtg tgtgaagatc gggtgttaca 52201 tttcttgcag gtgaaagcta tcatcatctt aggcttgtct accttaaaag accccaaatg 52261 aaccttctta tcgtcctttt tcacttcatt atgtgcgatg atattggtat gcaacgctgc 52321 tgcgggtaga gtacggcaca cgttgtagcg tacgcgaggc gcccaacatc tggcaaagta 52381 cctggtaatt ggtattttac tttgcagtag tgttctagtc ctcggaatca tgttcagtct 52441 cttgatattc cagttgcacc ggtgctgctt tagtatcgct gatcccttga agccaacatg 52501 acgctctttc acctttcctc tcataatttt gatatcacgc gaaaatgcaa gaaaaaaaaa 52561 ttacaattat gaagtgcaga aggaaccaaa aatatcatcg aaagaaggag tacgtagagc 52621 gttactattt tcaatcagtg ttcccattgt gcatacaaga aatgtctcaa ccccagatgt 52681 cccctgaaaa agagcaagaa ttggcctcca agattttgca tagagctgag ttggctcaga 52741 tgacgcgtca attaaagctt ggtttaagta atgtcccatc aacaaaacga aaacaggact 52801 ctacaacaaa gaaaagaagc ggagaggatg ccgaagatgt tgatgaggac cacaaaactc 52861 ttttggaagc catatcgcct gcgaaaaagc ctctccacga tgatacaaat aaaatgactg 52921 ttatatcgcc cgtaaaattt gtagagaagc caaatactcc cccaagttca cgccaacgaa 52981 aagccgaaga ccgctcacag cagatcaagc ctaggaagga ggacactcca tctactccga 53041 gggcttctgc tacacctata atcttaccac acgcttcgtc acactaccag cgcccccatg 53101 ataagaattt catgacgcca aaacgtaata ataacaacag cagtaaccat agcaataaca 53161 ataataatat caagaagaag gcagcaggct ctaaggatgc tccacaggac agcgacaaca 53221 ctgcgggcgc tgatctctta atgtatttag ccacaagtcc atataataag tcatcacatc 53281 atggaacacc gatggccgta aggatgccca ctactccacg ctcttatcat tacgcgtcgc 53341 aattgagttt gaacggtaat acagcaagca catcaaacga tgcagtaaga ttctctcata 53401 tcaaaccttc agcgtcttct ccgcagtcca ctttcaaatc taatctgtta ccgaattttc 53461 cggacgaatc tctcatggat tctccatcac tatacttgag caataataac ggtagtgtcc 53521 aggcgacact atcgccacag cagagaagaa agcccaccac aaacacattg catccaccta 53581 gtaacgtacc taccacgcct tcaagagaat tgaacggtac caattttaac ttactcagga 53641 cgcccaactt caacatggga gactatctgc ataatctttt cagcccttca ccaagggtcc 53701 ccgcccagca gggagcgtca aacacgtcag cttcaattcc ttctgttcca gcgatggtgc 53761 ccggatcatc ttccaacact tctgcgatag caacagctgc tatatcaagc cacaccacaa 53821 acaattttct agatatgaac gcaaacggga tcccgctcat tgtaggaccc ggcaccgacc 53881 gtataggcga aggggagtcc attgatgaca aactcactga ttgatcgttg acggccatat 53941 cagttgatga ttccatactt cctgaaatgg accactcaaa gggacaaaaa tgacaaatgt 54001 tgaaattata aaattacata ttaatacgta aaatgacatt cttttttagg gaaattcgga 54061 gatagattat cactatgtaa gcttatgtat cgtaatatac agggccgata tttcacctag 54121 tttacttttt ctggtggcct ttatgtttat gactgtgccc cctcttgtgt ttgcttttag 54181 aggctttctc tacaggtatc agtatggtgt cctcatcctt ctcccctgcc tctgcttcga 54241 ctggagctaa cccattttcg ttcttaaaag ttttcttcct ccactctctt aatcttcttg 54301 ccttcatcac tttcctttta tccttcgctc ttagttcctt ggaacgataa ggtgcaaatt 54361 tcttcaaacc aataaattca tttaaatcag tatcatcggc ggcgaaaatc tctcttgcgg 54421 tcaaaccgaa actctcagga gaaacttcac ggtaacgaaa cttcaaatct tgctcctctt 54481 ttgtacggct tctactcttt ctttcttctt cttctttttc aacctcctct attagtgcta 54541 gtttgttttg ttccaaagca ttttccacta attcatttac ctttctcttt tctttcttct 54601 tttgcagttt ctcttctttc ttgctcttct ttctttttgg accttcttcc tcgtcttctt 54661 ctttttgttc tttttccact tcaccttctt ctgtttggtc atcaccatcg gcgtctgcat 54721 aaaagtcacc cattatttcg tcatcctcgt tccaggtagg ctttccctct tgttgataaa 54781 attcttcatt aaataattca gctaccacgt tatcccactc ttcttctttg aaatcgttct 54841 tcaatagggt gtcagtgatt tttttcacca tgtcggcatt aatttcagca ccatattcct 54901 ttgttagttg ctctaaaatg tcagtcaatt tattcaattt tttagtcttc tttttctgaa 54961 gagctgtctc cttctctgct tttatttgct ctttaatttt tcttttttcc tctctttttc 55021 ttctgcgtga agagtcatcg gatcttctta gtgtagcttg actacgtgca taagatataa 55081 tttcagctgc gtttgggtcc tcgtacctaa aattgtaggc attctcaaat ttttctgcag 55141 catcttcaaa ttcttcatcg tcctcttcat tattgttgag gtcaagagaa atcaccttgt 55201 cccccttctt aggaatccag gcctgttgat tcacaaattc ttccaagaaa ttttcttcat 55261 ttacggttgg atccggtaaa ttttttcctt ccttcttcgt agaaggttcc tttttcttca 55321 aaaacccatc gtcttcatct ccgctagact cttcattttc ttcatcgcta aaggcactct 55381 tgatttcatt taaaagctga gttttctctt cacgttgttg cgagacgaaa gattgctttc 55441 cgtcaacagt tgcatgttcg tattcttcgt catcctcctt taaggcatca ccagaaagta 55501 tgttcatacg gtgataatct tttaggtaaa taggtttatg cttcccctca cgattggcca 55561 gtttggcagc agcagattcg ggatcctcga agaatttgac tttaggatct agtagtttgt 55621 ccgtcttatt gtttttgatg gcatctagca cttgattaat accgttttcc acttcatcag 55681 taatcaattc accgtaatca tcttcctcct cttcttcctc ttcgtcttct tcctcatctt 55741 cactaggaac gtacgatttg cttgcttcga ttgcaggctt aactgtcgtc gcagaggttt 55801 cagaagtttt tatggtagca gtatccgttg caggtacggc cgcttctttt tttgcttgtt 55861 ctctagctct tttagcggca gacttttttc ttggcattga atttagggta tatcacactg 55921 ttgttgaaaa ctatgagcat tttgctttct gaagaaatgg ttctgttaac tagatgagat 55981 gagattgata tatttgaaaa attttaaccg atgaccttgc ggctcctccg ggtaatactt 56041 ttttctcaca taaatatcaa aaaataacga cggtatttca ataatacttt tatataagta 56101 atgataacat gcgaggcaat ttattacaag ccacgtaggc ctaattaaaa ttataaacta 56161 acactaaagt aataataata tttcagatta ataaaagaac aggaaatagg aaagagataa 56221 aaaaaaatta ggaacataaa ataaaaaata aagaagaaat tgaaggagtg actggataaa 56281 agaagtgtat gataatatca aatggaaatt tgaatatatt ttattccaaa aaattttttt 56341 tcttttccaa gtgaaatata aacagcggat caaaggtgaa aaaaatcata gtattttgtt 56401 cattaaattt tccgagggga aagagaacaa attaatagaa aattattatt cagcaacttt 56461 cgtaggttta attttatcag caaattcacc cagaatttgt aactcaaaat cattaaaatc 56521 aaacaaattt ggtagcttga ttggttcagt gaaacctctt ggtaagaaag tgtcatcatt 56581 ccttaattca ttaaagaact gatgggcaag gattcttctt ggagacagtc tttgttgtgg 56641 ttcgtagacc aatattttca tcaaaagatc gataccatct ggaccggaat ggccaaaata 56701 cttctcaaac ctctgttgcg aagagcccga gaacagtggt ttggaaaata gagggccatc 56761 gtaggccgga ttcgaaaaga aaatgaatct tttatcggga ggacctaaca atttagcaat 56821 ttcccttagc tgtagaaggg gttcttgacc ttgaaatatg gctttgccga taagcatctc 56881 gcccatgaca caaccaagcc cccatatatc gatctgggtg gtatattggg tacaaccaat 56941 gatcaattca ggcgctctat aaaatcttga acagatgtaa ctaattgaag gctggttatg 57001 ttccaatttt ttggcagacc caaaatcgca gattttcaag acaccggttt ccgggtctac 57061 aagaacattg gatggtttga tatcacgatg acaaacgcca agaccgtgta aataaagcat 57121 cccgcgggca atctgataag tgtatagcct gatatgtttt aatggcattt ctagcttgtt 57181 tgtcacataa cgattaatct cgatttgtag agtttctggt aagcattcca tggcaaggtg 57241 ttgataaact ttattatctt gcggggacaa atgagtaaag aaatactgca atttaacgat 57301 atttggatgg tcggcaatcc tcagaatctg taattccctg gacttgtact cggtatgagc 57361 agggactttt ttaattgcaa aggggcccaa ccagtttttc ttatcctggg ttaaatatgc 57421 ttgtacaaca gtcccaaagg cacctctacc gattttcctg tactctttca ccagcatccg 57481 cctcgtgttg ttcgatttat tcgaggttac atcgtctgca atgaattcag atcccctttg 57541 cagaggaaca ccattctgct cttccgtaga catatgtact agaatgtgat ggagtggggg 57601 tttcggaaaa taaaaagaaa attgaaagat gaagcaaaga actctgtagt cttgggctta 57661 actcctatca ataaacacgt tacgggcctg cccacactac taacacgaca caatggcact 57721 cacttgcgaa atctatgtcg ttttcccttg gaggttacgc ctgccctctt ccgcatatga 57781 aggtcgcttt tttcagtgtt gtttgtgggt cactgaactg tcattacata cgaactgagt 57841 ggaagcaaga atgctgcttt cgaaagccac tacagctacg tgtgatcata taattcctgc 57901 ataatatggc tgcatgcttt ttaatgatag cttcaattat gatgataatc actgagctac 57961 tagtattcca ttattcagcc taagattgga actttctata gcagcggaga gtgtttgttt 58021 cgtacttcgt gactgtttgg cataataacg atgaattggg aaagagggaa gacaaaatga 58081 gagtaaatca ggtggaaagc agtggttctt ctgaaaagaa aaagtgacag tgtgaactgt 58141 tatagttacg tgtgatgctg ttacaacctg tttggaaagg ctgccgatgg acgcagtttg 58201 tcaggcctat cagaagatgg aattctaccg gcacgaatag aggagttcct ttttcattta 58261 aggatatttc aaatcaggag gatatcacga atatctcgta tccttcgtcc tctgactcag 58321 ttttgacaaa gtcaaatggt agtagtgagg tttacaagcc caaagaggaa gtagttaagt 58381 acattctaca tggcaagttt actaaaaata acacgcattt gacattttca agcgttgtgg 58441 aggacaagaa ctttcataag aataagggac ttacgtataa tgatacaatg ctgtactatt 58501 tgaacttacc ccagaaagtg aagatttcgc tatctacagg ttgtttaggg tttaggaagg 58561 cagcaagagg ggagtatgaa gctgcatttc aaaccagtgg tagaatgttt gaattgatta 58621 aggaaaagaa catgctgaac aaagatatcg aagtggtgat ggacgacttt gggaagggca 58681 gagctgcttt tatttccgct cttgttggta aggaaggggc cagtgtggtg aaaaaggttg 58741 tgaagatcag cgatgccacc aaattgaagt ttggtggtgt aagatcacca aagatgagaa 58801 gactatgatc agctcccact atgtatgaat tataaactat gtaaaagaag aagaaatata 58861 tatatattcg tgtaaataat tcgatttttc ccttttttta attgtcgtcg ttagagttgg 58921 ccaaaatcct taaaatagac aaaaacaaat tgacgatgtc caggtaaagc atcatggcgc 58981 atctaacttc ttcatcagga tacactttcc taaaaatcag ttgcgtatcg atgaaaagat 59041 acgcggtaaa taaaatggca ccaagccagc cgtaaagcag attaaacttg gaagagtggg 59101 tattccagcc gaaaagcaag gccgtgagac ccattccgat cataatccat agaccccagt 59161 ttaaccaata gtatattgac gttgcggaat tcagcacgtt ctcgaatctc tctgatagtg 59221 cggtcaagga aacgccgact acgacgatgg tggtgatcag cagagccgaa agtactgtat 59281 ccttatcgta cgctaaggtt accagcgaca gacagtaagc ctcggaaaga gtgaaaatgg 59341 agagcagcgt gagcttttgc ttgtacgagg acaagacgta ccaaggcaga cgcctttgct 59401 cttgtgccgg ctcttcgctg ctgcccgtga gcaacggttc gggaacactg gcctcgtagt 59461 cttcgggacg aggacttact gccagccaaa tgcacgatac tagcgatacc accatgcaga 59521 tgtagaagag ggcgatatgc gacatgataa agttctgcaa agaagtggaa acgctagccc 59581 agtagcagaa cgacaaactg gccagtaact ggcatgacag cagagagtaa accttgtgca 59641 taaaccgctg gcgaatgatg ggttcgcacg agataaccac cgtggaatat ttaaagtctt 59701 ccgggatgaa agcgtttcca tcctggctgc tcgcaggctg gccgtaaaga tgtgagcttt 59761 gctcttcgta aggaggtgga ggacctgaca tattaacttg attctatatc cttttatttg 59821 ctgttgctct tgaaatattg tcaagagtaa gatgagtgtt atagctgatt cttttcttta 59881 tcccggaaag atccttatta tagcctcaaa aggggagcgg ccgggtaccc tggttgcgtt 59941 gccgccccaa tctgccatag gcccacccat aagagtttag aaatgaatta ttcctgggcc 60001 aatgctgcga tcacgaaaat tatcaacatc ttgataaatt aatagcaagt tggactaact 60061 tacaggtttt ctcgtgaggg aagtggaaga gaaagaagaa aggagcgtat gcaactgccc 60121 ttggcagccg cccatcgtca ctcatggccg ttacgcgccg cggccgaaac acgccaaatg 60181 ctatgtacat aacggaaatg ctaatacgta acaatataat aatataaagc tttcataagt 60241 cttggcactg gcacttgcat cagcatctcg tatattagat acatcatcaa gtccatatgt 60301 cccagagaaa gcgatactca ttgaacgtcg tcacgtcccc gtcgataccg tcaccgacac 60361 ccagtgcacc gatacggact aacgaatcca attgggaagc tgcttcgcca gcgagtgctg 60421 catcttcatt tctcccgaat gttcatcatg gtggcacggt tttgaatcct gggttgggca 60481 taatgaggtc accttcgttg aacaagtctg gtgcgtttgg ccggtccggc agcagtggtt 60541 ccagtacagt aatagaaccg tccaacataa agttgctgct aattggagat gcaaacgtag 60601 ggaagacagc tatgattttg agctattgcc gggaactgtt gacacgagcg gaaatgtcac 60661 gatcggcgcg actgaggcac cagcagcagc aacagcataa agacttagga ttgaagaaaa 60721 ctgtggtgaa ccatagatta agcatgaaag agaaaagaaa acggtacagc tctaacgatt 60781 ttgaaaagga gttcaaagat attaatcatt ttgcagacga aacaagcgat ttcggaaacc 60841 cgaacatcgg tgatgataac aaccacgaaa tggcggatcc taatgagatt gtcatcgaaa 60901 ccagaagtac tatcggaata gacatcaaga cgaacttggt caacatagat aaccggtttt 60961 ttaatgtcat actgtgggac actgcgggac aagaacggta ccaaaacgca atcattccat 61021 cactgtacaa gaagactaat gcggtgatat taacttacga tataacaaat gcgaagtcct 61081 tccaaagctg tatggagcgg tggatagttc aggcgttgga aaacttttct tcccaggatt 61141 tgttaaaagc aagatttttt ctggtgggta acaagattga cctttataag gaaaggcagg 61201 taacccatta tgatgtggtg caaatggttc aggaaatgca actgaaacat ggtattaaaa 61261 tttcgggaaa ctttgaagta agctgtaaat gggtcaacgt ggtggagaga accatgaata 61321 tgataatact agacctggtt gagaacggat gtttcgaaaa caatgatcct tgtgtgtcga 61381 ttacaacatc tgacgacgtc cagggacatg agcaagaatt ccacgataca gtagaagagc 61441 ctttcaattt cactcggcaa cgtcaacacc aacttgaaaa aaataacaca gtggatatta 61501 caaaacctaa tgacgacatt gcaaataatc aatcaatttg ttgcgtttag tcttcgacaa 61561 attatacaac aagattcgca ggcagccatt gtccaatacg ccaatgtcat tatatgtacc 61621 aatatagacg cattatacaa tcctacaatt tatatcattg taaaattatt tactaccact 61681 tattcttcaa tggtgttttt aatgttttgt agaggaaaac ttaaaagttg tcatttttat 61741 tcagatcgca atccatggtt tgacacattc tatcttaaaa aaacaaaatc tatttatttt 61801 ggtttcggct atattgatga tgatgaatgt acatataaaa tggcaaaatt taaataaata 61861 aattatttaa aatcaatttt gtttgagtta aacgataata ctatagtata atgataatat 61921 taataaaaat cttagctttt tatttttaac aactcgctta ttcgtcttct tccaaagttt 61981 gagcggcaat acgatccaaa tctctttgac cgttttcaga gattcttcta ccaccctttg 62041 gagagatttc gacaataccg attttttcca aagcttgcaa gacctttctg ttgatagaac 62101 cggaagcatc aatgtgcttg tatggtctga cacctctgct cttggcacca ccgtacaatt 62161 tgttcaactt accaacaccg acttgctttc tcatgtaaat gtgtctagca acggaggcag 62221 cacgcttgta gaaccaacct tcagcgtctt gtggtggcat ttcattacca gaagaggtct 62281 tgacaatgtc aacgtaacct gggacttcta atttaccttg tctttgcaag aaagaagcgt 62341 aagcattgat gaaatcttga gctgcaacgt ctctaattga aaaaatgcac aattgaaatg 62401 cttttgttag taaaaagttt tctcgtaaaa atagaatatg gaatgctcag tgaaatgttt 62461 attgagacaa cttcttggtg cggcagtatc gtggtctcgg gttgttgctt aaattaacgg 62521 cataaaaatc gcttttcatt gcttttgcat taccacggtt acagatttcc ttccaactta 62581 aacgtcttgg ttcaggttct cctatttcat tagaaaacat cccacctagt taaaacctcc 62641 tatcaatcaa ttccaataaa taaatgatta cctcttcgtc tgagaacttc attttgtata 62701 gttggctcaa aatattctct ccacaattac agcaattata tcataatagt ttaactcatt 62761 cgttcggtaa atgcacagta aagatgaact tcaatttatc aggtaatggg aaattctgca 62821 ctaaatcctt tttctcaatc ccatatgttt tcatctcgtt gttttccacc taatatccat 62881 tcattctcta aatactcatt caatgagtga aagttatacg tacctaacgg aaacacctgc 62941 catctttatt atctttggtt ctataccttt gttgtcaata ttcacaaaaa tcccacttta 63001 aaatttcatt agtccatttt aacgattgta tcttcactaa tgttcgctta ttgaaatggg 63061 cacaccaacc gcgttacggg tggctcccag ggagccgtaa actggagatc tcaatacagt 63121 agaaagaaca gcaatgtgca aaacctcacc aaacaccagg gcttgtcact agagctccgt 63181 cctgctgggc tcaaacgcgc ctaatttatt cagggagaac ggacggacgt agacgcgatt 63241 tttttgtcaa agcacaaaaa gctgacatca ggaagaaaat caatagtgca ccaaaggtat 63301 atggtgtggg ttgctaaaat gttcggatgt aaagtagtat tgaaaaaaaa tgggaaaagt 63361 gtgtgaatga tagtttgtag gtttatgcat agggcggaat agctgacttg atactgaact 63421 gataggttta gattatgaag ttattataca tgtatatatt gtagtcagtc atatggtatg 63481 gaaaaatccc tctttcccaa cctaatatac actgaaacaa ggaaaaagga acaaagaaga 63541 aaaattgtaa ggtttcaaac catactagat tacaccttga aacccttaga tcttcttcta 63601 cctctagctc tttcgaactt tctaccggtg gacaagattc ttggagcctt acccttgtgt 63661 ggacccatac cgaagtgtct gaccgcttct ctggagtttc ttggacctct caagatcaaa 63721 gtgttttgac ccttaggagc tctgacagct aattgatcta aagtgataca ttcaccgcca 63781 gccttaacga tcttggctct ggcaccagca gtgaatctca aagcagcaac agtggtcttt 63841 gggaattcga agatcctggc atcgtcagta acggtaccaa caacgacaac agtcttgttg 63901 gcagcacctt cttgcttcaa agctctagca attctggaga ctgaaacagg tggtctgttg 63961 atcttagaca agaacaaagc cttcaaaaca accttgttga atggagcatc agtacgacct 64021 gtgattaaga caagaaaaac aaaagttttt acgttatgtt agtaaaggga taaaggattt 64081 gttggtattc tcgataggca gcttttaatt tcttccatta attgaagcca aaaagagtgc 64141 aaaacgaaaa agtaccaatt tgtttttctc tttgaagaaa aaagattctg ctcagttaat 64201 agttggtccg cacttgaagg tcgtattgta cttcctttag tactcgcaga atttccagaa 64261 aactaccgct ttctgttcta gtggaaatct ttaacacaaa agagaacaaa ttccactttt 64321 gtctaagaga tccgtcgcac gcaacgatac taagactgaa gccattagaa gatcgccggg 64381 actagaagtt aataatatca cagaatcctt ttatcctgaa gaaaattggg agggagattt 64441 caatacatac gagctaggaa agtgtatagt ttgaccaata atttcaaata gacgttatcg 64501 gattttggag cggttctatg accggatctt ttgtgttgct tggaagtgtg atcaataccc 64561 attttgtttt ttgttttctt ctaattgatt ttttctttct atttcctttg gtgaaacagg 64621 tagttttgtt caaaagaaat cattcaatgg tttaaataaa agcaagaagt atgaaaattt 64681 ttttattttt tcttcagaat tttatcatag ttgtcgtaaa ataacgaggt cgggtaacgt 64741 gtttggtgta ctgaggtctt ttttaaaaga agctccagca agaaagagtt ttgtgtgatg 64801 gctaatgaag tgtcaattgc atttggaaag cagcctgatt tcttgggcgt gaatatgaaa 64861 ttcttctttt gttattttat aatatgaagt atgaatgaaa acataaagcg cgctgagaca 64921 acgactgttc aatgtaaaat aaagaaaatc tatcgttctc aagacgtggt cccatttttt 64981 tttactttga atttcgtcag cagtgtgaca tggttagaat gtaaccccac atttgcaaag 65041 agattgttac aggagcgttc taattgtccc gtactggtac attcataagt gaaaagaaag 65101 ccatatcggg cgcgctggtt tgtgagccac agaaaccgga caaggcactt cttgaatact 65161 tcccaaggaa agcgccaagg tttacggttc tgatgggaat gcagggggga atctagtctt 65221 gaagtatcct tattccttaa aaaaaatatt ggacatcctc ttcgaaatta acaacgacgc 65281 caaaaacttg tctatgtttt caaaaccgcg cgtcacgaaa aagcaggaag cacaaagaag 65341 tgacgcgaaa atgacggtat atatagccat tagcagtcgc caaaaggtga agatcctgac 65401 acgaaatgta gcagagtcac tacattgata ctgatcttgt acttccgaat aaggcaccgc 65461 cagatcaatt ctgtctgatt ttggcgtctt ctggtatagt cttgtaatga acggtggtga 65521 ttctcgagga aaataaaatt cgtgataaat acatgcatgt gtatatataa ggcgctatat 65581 atggccttga aactttgtta ttacgcctac tccatcttta ttggtacata tatcatttaa 65641 aagagtagtc catagaaaac caactgcatt ccttccttat ccctgccttc ggctaatttt 65701 aaaccaactt tttaccttcc tttaatatca atatcaaaat acaatgaaat tctctactct 65761 ctccaccgtt gctgccattg ccgcatttgc ttccgcagat tccacctctg atggtgtcac 65821 ttacgtagat gttaccacca ccccacaaag tactacatct atggtctcca ccgtgaaaac 65881 tacttccact ccatacacta caagtaccat tgccactcta tccactaaat ctatcagtag 65941 ccaagctaac accaccaccc atgagatcag cacatacgtc ggcgctgccg ttaaaggctc 66001 cgttgcgggt atgggtgcca tcatgggtgc tgctgccttt gctttgttat aagttgcatg 66061 gacaacttaa actaggaagg atattccgct tcatttcatt aatttcacat ttttttatct 66121 acatgatatg tattttccct cagttaccag attcgctagc ttcgaagcaa ggactccttg 66181 gtcatactta ataaaggaac gtctgcttca ttctcctaaa gttcctttcg ataaggacgc 66241 agaaggcacc ttactagacc attgtataaa ctcataacta catactaatt caacgatatg 66301 ttacatttat tttcttgtgg ttaccccccg caaatttcca ggcatctcat ctcatcgcag 66361 ttaaaaaaaa aaaagttgta aaaaggtaat aaagcgatac ttgatgaaag caaacatctg 66421 taataacagt tcacaaggtt aagctggttc gtttcactag cgtatcattt tttatttttc 66481 aaataaacaa acgagggcgg agtttattgg gtcgtcatga caaggctcaa agcaaaatat 66541 tcacctacaa aaggtaaaag aaaagaagat aaacatacaa aacgtatgcg taaatcatcc 66601 ttcacaagaa cgcaaaaaat gcttgaagta tttaacgata atcgctcgca ttttaacaag 66661 tacgagagcc tcgctatcga cgttgaagac gatgacactt tcggaaacct agtcttaatg 66721 gaaaatgata aaagtgatgt cgacatacct gtaatagaag aagtcacatc aagtgaagat 66781 gaacaaaggg cagaatctag caaaagaaac aattctctcg aagataatca agattttatt 66841 gctttttcgg acagctctga agatgaaaca gaacaaataa aggaagatga tgatgaaaga 66901 agcagttttc tgttgaccga tgaacatgaa gtttctaagc ttacttcaca gcaatctctg 66961 aacactgaaa gcgcttgcaa tgtggagtat ccttggataa gaaatcattg tcattcgaaa 67021 caaaggagaa tagcagattg gctaacttca gaaatcaaag atttcgttca ttatatctct 67081 ccaagcaaga acgaaatcaa gtgcagaaat agaacgatcg ataaactacg ccgggcggtc 67141 aaggaactgt ggtcggatgc agatttgcat gtgtttggtt cttttgccac cgatttatat 67201 ttgccgggtt ctgacattga ctgtgtcgta aacagccgga atcgcgataa agaggacaga 67261 aattacattt atgaattggc gagacatttg aaaaacaaag ggctagctat aagaatggag 67321 gttattgtta aaacgcgagt gcctattatc aaattcatag agccccaatc acagttacat 67381 atcgacgttt catttgaaag aacgaacggg ttagaggctg caaaactcat cagggaatgg 67441 ctaagagact ctccagggtt acgtgaactg gtactgataa taaaacaatt tttgcattca 67501 agacgattga acaatgtgca cacaggagga ttgggaggtt tcacagtaat ctgtttggtt 67561 tattcttttt taaatatgca tccgcgaata aaatcaaacg atatcgacgt tctagataac 67621 ctgggtgttc tactgattga cttcttcgaa ctttacggaa aaaattttgg ttatgatgac 67681 gttgctataa gcatatctga tggttacgcc tcttatattc ctaaatcgtg ttggagaact 67741 ttggaacctt caaggagtaa attctcgcta gctattcaag atcctggtga tcctaacaat 67801 aatataagca gaggctcctt taatatgaag gatataaaaa aggcctttgc tggtgccttc 67861 gaactgttgg tcaataaatg ctgggaattg aattctgcta cattcaaaga ccgcgttgga 67921 aaaagtatac tcggaaacgt gatcaaatac cgtgggcaaa agagagattt caacgacgaa 67981 agagatttag tgcagaataa agccatcatt gaaaacgagc gctaccacaa gaggcgcacg 68041 aggatagttc aagaagattt atttataaac gacaccgaag acttgccagt agaggagatc 68101 tacaaacttg acgaacctgc aaagaagaaa cagaaggcaa aaaaggataa gagagaaggg 68161 gaaatcaaaa agagtgccat tccatctcca cctccggatt ttggagtgag cagaagcaaa 68221 ttgaaacgca aagtgaaaaa aactgatcag ggctctctcc tacaccaaaa caacctcagc 68281 atagatgact tgatgggact ttctgagaat gatcaagaat ccgatcaaga tcaaaaagga 68341 agagataccc cttcgggaca agatgagaaa tcaccactgg aaactaagac agtagatgct 68401 caaacgagaa gggactactg gctctctaaa ggccaggctc tttaacacaa tatagactct 68461 tatagactat ttactattta tacaagaata ccacatcgat gtccaagtga aacaataagc 68521 taatgatatc aaacgcgtgg gtattttccc tttccggaaa tatagagcca ccaaaaaagg 68581 atagtttccc gatatggaaa ttttctcgag ccggtaagat gacgaaattt ttcatctctg 68641 gcatgataga aacatagtat ggaacgtgca ggagagtctg attcgagaca cataatttga 68701 aagaaccttc tagcctgagc cttgtacatg tattagcgtt gccagttatt tgcttctgct 68761 gctaataaga tcaaaacctt aagtccttta tttcgatcga acgtactgcg ctactgaaaa 68821 ccattgcatc ttttgctatc attcattcct ggtggtttct ttggtgtaat aaatcgaaca 68881 gtgaaactga aacataaaag aaatagtgca aaatatgtct ctttcagctg cagcgaataa 68941 gatatctgac aacgatttcc aaaatatcgg accggcacct agacctccca gttcaaatag 69001 ccagggccgt acttgctata atcaaacgca acctataacc aaacttatga gtcaactgga 69061 tttaacatca gcgtcccatt taggtacaag tacctccaaa aaaaaaagcg ggtgggtgtc 69121 ctacaaagat gacggtatac tttcatttat atggcaaaag agatacctga tgctacacga 69181 ttcgtatgta gccctttaca agaacgataa acaaaatgac gatgcgatct tgaagatacc 69241 actaactagt attataagtg taagcaggac acagttgaaa caatattgtt ttgagttggt 69301 gcgctgcagt gaccgaaatt ctgtatcatc aggatcctcg tcctctttga atgtatcatc 69361 agacagtaac tccaaaaaat caatatacat tgctacaaag acagaaagcg atttgcatag 69421 ttggttagac gccatttttg ctaaatgtcc attattaagt ggtgtatctt ctccaacaaa 69481 cttcacacat aaagttcacg ttggttttga tccagaaaca ggtagttttg ttggtatgcc 69541 caccaactgg gaaaaattat taaagcactc cagaattaca ggagaagatt ggaacaataa 69601 ttctgcggct gtcattcaag tgttgcagtt ttatcaagag tataatggag ccggaaatcc 69661 cacaaatact ttagacaagc ctcaaagtgg tgaaacttcc tcctctcaaa aatcgctgcc 69721 aaacagctat aatgataaca aactcagaaa taattcagta aattcaaagt catcttcagg 69781 cgtttcttca agtatggtat cacagaggaa aacctcacaa ccaccaaata ccaaatcgcc 69841 tgtttctcta ggaagcggct cactgccacc aataaataca aaattgccca ctagtcagtc 69901 aaatattcca agacacttac aaaatgttcc caaccaacaa tatcctaaga tgagaaacgg 69961 acactcccca accaatggcc aatttcctag gggacctatg catccaaaca attctcaacg 70021 atctttgcag cagcagcagc agcagcagca gcaacaaaaa caacagcatc aacaatatcc 70081 ataccaccat caaggaccat ctccatctcc atccccatct ccgtctccat taaaccctta 70141 taggccacat cacaatatga taaatcctta ttccaaacaa cctcaatcgc cattaagttc 70201 acagtcgacc caaaaccaag caattccacg ttatgcacaa aactcaagtc ctacagccgc 70261 acactttcaa cctcaaagaa cagctccaaa gccaccaata tcagctccaa gggcgccata 70321 cccatcaaat caaaatgcta ctagtaacac acatgtacag cctgttgcac ctaagaatga 70381 ccagtcaacc ccacaaacaa tgaggcaggc cccaaagaga ccggatgcag atgtcgcaca 70441 accgggtggt gtggccaaac cgaagaagcc agcaaggcct accatgtcaa ctgcagaaat 70501 aatgagtaag ctgaagaaag tcaccgtaaa tgcggatcca tctcaatgct ttaaagtgat 70561 cgagaaggcc ggtcaaggtg caagtgggtc cgtctacctt gcagagagga cgcatattcc 70621 gacagaaagt aatatgatcg aactcataaa caatgatatt gatgagccgc acgtaggaga 70681 taaagttgct atcaagcaaa tggtcttatc taaacaacct cgtaaagaac tcatagtgaa 70741 tgaaattttg gttatgaagg attcacgtca taaaaatatc gtcaattttc tcgaggctta 70801 tttgagaaca gacgatgacc tatgggttgt gatggagttt atggaaggag gttcactaac 70861 agacattatc gagaatagtc ccaccaacga taattcacat tcaccactaa cagaacccca 70921 aattgcatat atcgtacgag aaacttgcca aggcttgaaa tttctacacg acaagcatat 70981 cattcatagg gatattaaat cagataatgt cttgctggac actagagcta gggtgaaaat 71041 taccgatttt gggttttgcg ccagattaac tgataaaaga agcaaaagag ccactatggt 71101 tgggacacct tactggatgg cacctgaagt tgtcaaacaa cgtgaatacg atgaaaagat 71161 tgacgtatgg tctttgggta tcatgaccat tgaaatgctg gagggtgaac caccatattt 71221 aaatgaagat ccactaaagg cgttgtactt aattgcaact aatggtacac caaagctcaa 71281 gcatccagaa agtttgtctt tagaaattaa acgctttcta agcgtttgcc tttgcgtaga 71341 tgttagatat agggcatcaa ccgaagagct tttacaccac ggttttttca atatggcatg 71401 tgatccaaag gatttgacat cactgttgga gtggaaggaa tgaagcacac aactatttct 71461 ataagcatat catacatact acaatcttat gtatttcttt tcttttagct atgcatacca 71521 atggcataat atataaatac gttcacctta aaagtttttt ttttaaagta aataaaaaaa 71581 gacctgcaac gatacaataa tcaatccaat gtcgtttaat attactattt atcctacgtg 71641 atttttaaaa atattcgtcc atgcttcagc ttctagtcta gtttcgtaaa tccaagtgat 71701 aattccaaaa ctttatcttg gaggccatcc attttatgag atactgggat ggttcttaaa 71761 atcaacggac ttaatgtttg taggttttca actccaattt gtttgttgcc aagggtcgaa 71821 ttttgatcta gaacacctct taaaatcacg catagcccat ttaatagagt agctagttct 71881 gttttacgca attttggtat tggtgctcgc ccaatcaagt attcatctga gatatatctt 71941 ctaagagcaa gggcaattct tgcagaaaga taaggagcag ttaactttct taatttctcg 72001 tttgtgttca acataaaatt aaccaaatct tgcaagcact ctaaagagca cttatatttt 72061 gtctgaaagc gaggatttgt ggtggatcca aatatacatg aaaaatcgaa cgaagatagt 72121 ttttgagaca attcagaaaa cgtaccacag tcttgcatca aagcattttc taattcatcg 72181 aattcatata aaaatgaaca atcccagacg gcataaatga aagtgtctaa ttgcctttca 72241 ttgaagagat caatgattct gttttccagc aatatctccc tatatttgga atactcattc 72301 aaatcgtcta tctcggttaa attatcgagc tctgggttga ttctttgtaa tgtgacaaca 72361 ataacattta taaataaatc acaaaagtta tcctttaatg gattttctgc atcttcttgg 72421 agtgatttga aaattttgtt cgacaaatca cagaagcaat tggaagcaag aacccatatg 72481 gggatttcat cactctctga ccctgtaata agcgattttc gcttgatgat ttcagccaaa 72541 tttttcaata ttcttaaaat atgctttgct ttcagtgtgg atataccaaa ttgatctatt 72601 tttgctattc tatttctcag gttagaacat gacatatagc tgattgcctc aaaagttggt 72661 aacctgttaa gtgatgcttt tggaagcttt ggtccaagtt tttttgttat tttttccctt 72721 gtatcaaaag ccaatatcga tattgtactt aactggagaa gaatcaaaat ttctgtatct 72781 ttagaatcat ttgtcataaa tatatcaagt ccagacaata tggccttttg catagaggac 72841 ggtttagttt tgtcttggac aaactcaggt aagagaggat attttatggc agaattgaat 72901 aaaagaagaa ctttttccac aaattcatct gtcatcgcat cgtatttcga tattaattgg 72961 taaagaggag gaaatccggt tattagttcg tatatacaat cgtattcagt tttgctcgat 73021 gcgtttgtgg agagatcact gtacgtaata ttgtagtcgg taaatatttc gcagcacttt 73081 ttcaatatat ctgatggaac gtcctcaata gtgatgattt ctttcagcag ggtttgataa 73141 tttaatatta cagcattctt ggtattatta gaagtggaag acaacaatct tttcaaaaaa 73201 tctaataaca ttgaccattc cttggcgcag gtagtgttgt ttttgaagtc cttaaagtgt 73261 tccggataaa gcttaattaa tccttgcaat gttacattta taaaatcagt ttcattttcg 73321 agttcttcag tggaccattc cttggtaagc agtggttcaa taacctctaa gaaaattagg 73381 tcccatgggg ggaagcaaac agaatgggag tcgatgattc tgaaaaaagt ctgcacagca 73441 ccgtttttaa cttctactct atcatcatta gtacaattga tcaaattttt caaaagatat 73501 atccataatc cgttgtaaag ttcccaatca tgagatgaac tggatgtaat gatttcaatt 73561 aatttttgat tattaatctt ttcggagaga cttctacgtt tctcatcact taaatttaat 73621 gtttcgggat tgaagcggac tctgagataa tctccaacta accagaactg actaatagaa 73681 gaaaaggaga tattaagatt tcgcttctga cttacgaaat tgacaagcgt atcaataacg 73741 aatttaatga cactcatagg taaactctgt aagaaatcat cagaaattag tttaaaaaca 73801 tcgtatgaca cttggatcat gttcttatgc ttctgaacga taccttcaaa taaagatgaa 73861 tcatctatat cctcattcac ggaaaaatca gtatcctcaa ctgtccactc gaatggtgaa 73921 ttaatgatgt tgaaaatatt ggtccaagag ttcattaaca gttcaccaaa ttcgttcaga 73981 atctctttta aagttagtag caattgaaaa agaatatctg attcaacatt gatcgtccca 74041 ttgtatattt cctgcttacc aatatccaac tgttttatcg agtttatcgt tgccatcaag 74101 ctatcgatga ctaagttttc caatgtacca aactgtttca ctttattatc ttgctcatcg 74161 gaattaccaa cctcattagt agcctttttg atgatatctg taaacactct cactgtgtat 74221 aaacgtaaag aatcgttatc catttcacgg tttgatatca atttgatcat ataggtggaa 74281 atcaaactcc aaagttcttt accatttttt ccaaagagaa attttttgca attataagtt 74341 gccagttcac caattttgtt aacaaaaaac gccttgttgt aaatgcatgg tataatttca 74401 tcttttgcat ctaaaggatg atagccaatg tcattattca ggttgaggtt cgtttgttct 74461 aaagtgaggg tattttttga gtccaaaatt aatctggtta ataccaaatg aaaagttgag 74521 caagaatagc tgcttgtact ttcaaaaaat ttcgttagag agctttcaat agatgtaacg 74581 tctgatttag tcagtattgg aggtggtgga atatcttcag agtaaaagct ctctttgaaa 74641 tctgctgatg gaccatatat gtagtaagtt atccattgcc aggttaaaaa agtgtacctc 74701 cagctttctg aatcgaaaat aggacctagt gatattgata atgatattaa tgcccttagt 74761 aaactaactt gtcttgaact aatattcctg gggtgcaaac gccttttcat ttccttattt 74821 tgcgcagaat ctgcaatcga cctacttgga ttttttgttg attctacggg actggtcgtg 74881 acactagatg tggatatatt tcttgtatgt tgattttttg ctgacttact tgtatcatta 74941 aaagaatatt gattggatga tgtaacgttg tttgttatca aaatcgaaaa caatttcatg 75001 catgccctta atttgtcctt tagtgacaga acgccggcac tatgagctaa tttttgaaaa 75061 gctctaacca ccaagtggaa tatcgatgtc tctaaggagg tcgaatataa aaagagtttg 75121 tttagctcaa ataggccaga aaacaggccg ctataaacct ttacaactgt cgaatcattt 75181 ccagttccct cttcacgttc tttgtcctca attttcttct ctaggggaga gctttccaga 75241 gccgatttgt tcaacccctc gcataagtgg ttacagatgg tcagaattaa tgatataatg 75301 taagtaatat taatggacgg agcgtttgat ttgtccaata aatgcataaa ctttgtttta 75361 actgtagagt tttcagtagt tatcaaggga gaatccattt tctcgactac ttttgatggc 75421 gccaagaaag taatatactc tggcgaattt aataagacaa tacattcttt caaaagatat 75481 ttgaacacat gttttttatc tggataatta tcatagtcca tatagagtgt attgacgatt 75541 tcggggtctt gtgataaatc cttgaaaagt tctagagata gtactctttg ccatccactt 75601 aaattggatt cgacagatat gccatggatt aacagcgaca agatgacctc taattctaac 75661 tcgagtatgc ttaggtactc ttttcttatc aacaacttca aacaacgaca actccttaca 75721 gcggtggaga agtgtctcga agaagatatg caacgtagaa gcaatggaat cgccttaact 75781 ctcagtagat attgtaaatc ttggcattct aaaagatttt tctgactatt cttcaaaatc 75841 gattcaagga tttccaggcc atagtctatt gggatgtccc caatgtctaa cagcatctcc 75901 tcgtcactaa ctgccccatt tgagcttatt tcatttaatg aacagatatt atcgaacaat 75961 ttgttagcat cgtatctata aacattgacc ttaattgact cactattact tatgaggact 76021 tcatattgtt tatcatccac tacagattca atggaaagcc tatcaaatat ttcatcgata 76081 agctgctgta aagtggcact cgcagtacca actactacgg gtgccttatt aggtacatgc 76141 agcagatttg agcaacacag caacaacttc ttacaaagcg gcccatagat gaacttcccg 76201 tatgtcttaa aaaaaatggg taccacctgt aaaactttta attgaatctc catcgcgaga 76261 tgagtagcct caatgaaggc atccaaaatt tcagacagcc ggcttcgagg aatagatgga 76321 acggttgaca gtccctgtag gcattgcatt gccagggtcg tcattttagc attccttgat 76381 tggcaagcca acacgaaagg gagtgcgaaa tccggatgtc tttctagctc ctcaaaacta 76441 tgtactcttt tcaatatctc aatggattta tcactagcat ggcgaatggt tgaatttctt 76501 cttttcgatt cggaagataa agaacgcaat tctgcttcaa gttgcctttg catggagtca 76561 aaccctccag tgttcatggc catatgaatg gtgtgtaaca ggtcaagttg gtttactttc 76621 tttgaaaatc acttgtattg catacagtct acaggcttta tttagctggg cttaggtcac 76681 cttaattatt aacacggacg atttaaaggt catccacgac gaccagccgg ctttatcaga 76741 aagtgggata atgaagactt cgcaatgact ttatgaagaa taagagcagg aggtttgagg 76801 aagtctgcaa ctcgatctga agagagtatt tgttagctgc taggacaata ttggtatacc 76861 cctttagtgt gctcaatttt tggtgaaagc agaccgtatc attagatcat tgcagaagta 76921 gtgagattta gtcgtacgtt acgtcatgga acaccaagca cttcgaaggc ttgtactgta 76981 ctgccccaat ttcatccgac gtggtgctct taggcaaaat atgactagag tgagctgtag 77041 acatatgtca ggcaagggtg gagggagaga tgagaaaggt gattgcaatg aagaaaagga 77101 ttcttccaaa gatttgggga gggtaccgtc gaagatgaaa cgagcatatg atggtgaaac 77161 agttattaaa gagggagatt cgcatgctga gtcgctagcg cagcagggaa agcagcccac 77221 agacctcgca tataacagca gatcgaagat atctggttct aatttgcatt tattggttcc 77281 tagagttgcg tctacagact atatttcgaa taaagaggtt cacacggagg gcctgtttgc 77341 cggctatcga cccttgtttc tggggaactc aggttttccg tctgatgcaa gaaagggtaa 77401 aaactttcat gagttagacg acgttcttcc caatatacag gtagtggacg cttccgagaa 77461 agatggcaaa ctcaatgtgc aggagattat tgaggactta caaagaacaa gtttgagaga 77521 aagcattcat agtatggaac agttaccatc ttcgcacaaa cgtaaacccg taataccgtg 77581 ggacgcatct ataagtggca tggtttataa tgacatgcct ttcaaatatg tgcccaaaaa 77641 tattattctg aaaatgaagc catttaaact tttgcgtatt gagagaaaaa gtcaagcgaa 77701 gaatgcaaga aagcctacta tgataaaact tcagtttcac aatcgaagaa tcaatgacac 77761 cccagagtta gtgaatttat accataataa atcccgtttg cacgagtcac tttacaatac 77821 aaaacccctt caagaatctg gatattcaag tgcaaataca agtaaaagac agaaaatgtt 77881 aaaagcaaga agcgactttg aacataaaca gaaaaattat gcatacaaac acacatttat 77941 caaaaatgat caggaactgt tccgcaatga actaactaag ttaaataaga tacttgctag 78001 agaattcaaa aaattgacaa agctatccat acataatgag ttcaagagag aacacttgcc 78061 cctggccgtt tatgtgagca aatcaaaggg cacaaagaaa ctgtttagaa gatcactgaa 78121 gatgaaaatc atggaccaca tatacccagt ttataccacg atattgtcaa ctttaacaaa 78181 ttccagagac tctaagaaat ttgaaaacaa aatcaaggcg tatattgaaa aaatcatagt 78241 gcggttatca gatgaagtac catccacata ttttttccaa gatggcgtag attgtattat 78301 tcaaccaagt ccgattcata atttcaagag aatgcattgg ttaagataca ccaagaggca 78361 caataccttt tgggggagga ctatacataa ggacgttcaa gtcagcttca atgacaagta 78421 tgttgttact aggagcggcg tgaggtatac gaggtatccc actaatttga atacacaatt 78481 attggaaact gcatttgaag aatgggacta ctatgagtga ttttgcattg agtacttatc 78541 cactgctcta ttatgtgaca tattcgcaat tcgtgtaaat attatgcata tgcatcttga 78601 gcatgcatgg aatatataaa tatgtaggtt tgttgtaata ctgtttctgc tgtgtccttc 78661 aaatatggcc tatatggtcg ctggtaaaag tggcagagct attgttattg ccttcactgc 78721 caacttcata ttcatcgtca tcttcatctt ccgcgttctc atcgtcatct tcatctgaat 78781 tgaaaacgac atcctttgtc gaataaatgt atatgcctgg tttgtctaat cccaaccgtt 78841 tcctgaccat ggcctttctc tgtttggttt tttcattttt cgagctgctg ctattattgt 78901 ggcctacgct tttctggacg atttggtctg taaagtataa aattttatca cgcgcatagc 78961 ctaatttctt cagcgctaca tctttataag ttcccctatc attgaaatgc attcgatcaa 79021 tgcttctgcc cactgatatc tgatcttctg ggtcgtagcg tgatatggtc tgtaaatcac 79081 atacttccga attacttgac gtatcgtgcc gatccgttga tgcgtcctga gattccctcc 79141 tggttaaagc gttttgaacc cttaaggcgt acttggcaaa ccgatagtct tgttgctctt 79201 cctcgaagat aggtcttccc aaaatgcttt gcgcttcctc ttttctttcc aaaacattta 79261 atctatccag ccactcccat gtgatcacgg tcgaagtgac atagcatgtc gtgttaaaca 79321 cttcacccag ttccgatatc cataagttcg acacatcggc aaggaagaaa cccggtaata 79381 gaagcaccac aagaatagtc aatagcgtaa gtaaacccat ttgattgaat ttaaaccaca 79441 attttttttt ctgccagatg tgataaatga cgattgatgc atatgacgtg gcgatggcaa 79501 tacggaaaag gtaaacaaat ggccgcagaa tctgccagtc atttctgtgt tttgtagtat 79561 ggttagcaaa cggtggaatt acccataaaa tatttgcggt tattgttaat atcaccccaa 79621 taaaaaaaat tattctcttt tcctgagctc tttgaaatag cctaatgaca atgccgactt 79681 ggcaaaattg gaacattaaa gtagccaaga aatccaagac aacaaatgtc atatcatcgg 79741 aaaagatgtg cataatggaa tgagcccgaa cgacaccata gacattgtgc tctttttcca 79801 atctccgcaa caccttcgtg ataaaaatcg ttaagttcaa cgaggctaac aacgaggcta 79861 tcctcagtag ttgtagaatt ctcttatatg cgcgcccgct gatatttata cagcatatca 79921 cagtcaggaa cactgtgatg acaaaattag aagttatcga caaaatcaca gcataaatcg 79981 catactcagc agaaccgccg acataatcgc ttacttgaat gaatttttgc cagtcattga 80041 tcacctcatc aagataccta tatggggaag agtttcttag caccgtagat acataaacgg 80101 gcactctttc acagcagaaa ctcctaaaag taatatcttc tgcatatact gccgaattgt 80161 cataaagagg caattgtatc agcacccctg aacctagctt cattggatga cagctattgt 80221 aagcagccaa ttcttctgga ctatgtctcc acaagttcat gtttgcagaa tcgactattc 80281 atcgagtgtc ttcctcctta tgtgctacta aaaacgatag tctaaaatga ctgattaagt 80341 gcgcacagga aagaagaaaa caggtaaagg acaccgaatc tgtagtacca gtcttttgtc 80401 tttcttgtaa ctaaacgatg tgggttgctc ttctaaagta cttatcttta ctcgccgata 80461 caacgggttc catcttctct ttcaatagct gctatttttc tgttcgggca gtatcagaat 80521 taacaggatc aaacctcgtt tatgtcacgt agaaagaaag tagctaaaaa tagctaaagg 80581 gacatctaga agctttgtag gagtcaaaga gttgcgcacc cagaaccatt gtaattagca 80641 tgcagaacga tcaacagagg ttctccctgc aaaataggac ggtactggcg catccataca 80701 aaaggctagg aggggcattt acggtgaaat caccgtctgt tcctaacttt catgataaaa 80761 tgcattcaga tcatagttct agcgactcag ctctggtgaa cggaagcttt agagcgaatg 80821 atcatcgctc tgtggaacca agttgtttgg gccaagcatc cccctctgaa catgatggga 80881 atttaagcgt tattgacctg tatggagacg aagtggaatc ccaacgtgcc gaaggagagg 80941 atgatgatga taataatggc gataatggta acgaagatct ggaggaagtg cacagtgatg 81001 acctcgattt ggttcctgat gatgacaacc gtcagcgtgt agaattggag ggtgccgcta 81061 gtgccacaag tgcgaattcc aatggaatca acaataccca ttttgatcga tacggtttca 81121 aaaaacagaa taattacata tctgaagcag aatacgataa gtggtgggta gaatattcgc 81181 agtactgcgt tcgccgtaag cacaaatggc aattgctgtt ggagaaaagt gggttgccag 81241 tgaccgatga ttctccttca cgatttccat caaagagtga acggttaaaa aggtatgtca 81301 gaaagggcat tccagcggaa tggagaggaa atgcatggtg gcatttcgct agagggcaag 81361 agaagttaaa caagaataaa ggcgtctatt cacaactttt acgaaagatg aagcagatca 81421 agaaacaaaa ccctaatgaa aaacaagttc aagacttgga tattattgaa cgtgacttga 81481 atagaacatt tccggacaat atacatttcc aaagtagctt gcataacaaa gagggacctc 81541 cgattataaa atctttacgc cgggtgcttg ttgcgttctc tctctacaat ccgaagattg 81601 gctattgtca atctatgaac tttcttgcag gcttgctatt gttattttta gacgaggaaa 81661 gggccttttg gatgctagtg attattactt caagatacct accgggggtg cataatatca 81721 atctagaagg tgttaacatc gaccaagggg tactgatgct atgtgtcaaa gaatatattc 81781 cagaagtttg gtcgtacatt aagccttcca ttgaccacca ccaaaaaaat aacaaaactt 81841 tttctccgtc aaataaaaaa gttttattca atatgcaaaa gaatgagttc ttgtacagac 81901 ttccgcccat tactttgtgc acggcgagct ggttcatgag ttgctttgtc ggtgtagtgc 81961 cgatagagac cacgcttaga atatgggatt gtctgtttta cgaggaatca cattttctat 82021 tcaaagtttc gttggctgtc ttaaaattga gcgagcatga cctttcgaaa ataaaacctc 82081 gtaacaattc gttgaattat tcttggggct ctaacttaaa ccagagaggc ggatcaatgg 82141 gccaagaaga tagcgatatg gaaatttttc aggtcataca gacattccct aagacattat 82201 tgaacccaaa tgagatcttt gagaaaatca ttttcaaaag gagatttaat ttaaataggt 82261 tagatcagga tgaaatagac aggtgtcgaa aatttgttgc cgctcagcgt ctcaaattta 82321 agacatatgg tgaacttctt ggaaattcaa catcagaggc agatttgcca attaatgata 82381 atacagataa taaaggtatc cacataacaa gtgatgcagt caatgaagca ttatcttcag 82441 aggtatatgg gtttaaaaag agcctagctg gagttcattg gaataatagc atcaaggaga 82501 aagtgaagca gatgaggaag aaaaaagaca agggtgacta acttttgctt cctgtttttg 82561 tttttgcata aacaaatatg tgataattaa ctagcatata aaacatatac atatacacag 82621 acttattttt ttttgagcat ctatatttca gagaattttg tttggcgttt tttctctggt 82681 attgatctgg caattttcca tgatatcttc taacagcgag gtgaaaaatt tgttaaagat 82741 gagctaagct tgtaaattgt gtaagttagg gcatcacata aaaagaaaac tcaatcaagg 82801 ggaacatgaa tggaatattt gctattgaga agcctagcgg tattacatcc aatcagttta 82861 tgctaaagtt gcaacatgct ttaactaaaa gtcaagtatt ctcgaaggaa attcaaaggg 82921 caacagcgga aagaaagcag caatatgaaa aacagacagg taagaaggcc agcaagagga 82981 aacttcgtaa agtctcaaag gtaaagatgg gacacggagg cactttggat ccgttggcct 83041 ctggtgtcct ggtaattggg attggagcgg gcaccaaaaa acttgcaaat tatctttcag 83101 gcaccgttaa agtctatgaa agtgaagccc tgtttggtgt ttccactact tcaggagatg 83161 tagaaggtga gattttgtcc cagaactccg ttaaacattt aaatttcgat gatttaaaga 83221 ctgtggagga aaaatttgtt ggacaattaa agcagacgcc gccaatatac gcagctttga 83281 agatggatgg caaacccctg catgaatatg ctcgagaagg aaagccttta cctagagcca 83341 ttgagcccag acaagttact atttatgact tgaaggtgtt ttcagactct cttaaacgtg 83401 atcatgacta tcccttattg aggcccacta cagaagaagc tgttgatacc gtgaaaaatt 83461 tgaatgcaaa catgctaaac gatgttttat acttttcaaa agaatataca gagaagcacg 83521 gccttgattc tgaggtggca aaggtagaag aaccatttcc gctgagtgaa caagaagagc 83581 aagaaatcca aaaagaagga gattcttata gggctccaaa attgcacttc aaagctaatg 83641 tgtcttctgg aacatacata aggtccttag tgagcgacat cggtaaatct atgaggagct 83701 catgttatat ggtgaaattg atacgtttgc aacagcagga ctggtctctt gaaaaaaata 83761 atgtgttcca attaacggat tttactgaaa gagacgagaa ggtgtggagt aaggtactgg 83821 agaaggttct agacgaggga gcaactgttg atgttataga agagctaaag aaagcagaaa 83881 aggaaatacc agcggacgtg aaggaatgta tagtttcgag tgatcaacct ggtgatgagg 83941 ctacggctga aacaattgaa actgctaacg ccgaagaaca ttctaataca ctaaaaagaa 84001 aaatcgaaca ggtgtaaaaa agaggaagtt cgaaccattt ttttttttgg tcttgtgaag 84061 actacgctct cattttatct atttttttat gtgtatatat gatttaaaaa aaatcgatgt 84121 acttatgcat ttaaatcgtt caattttttt gtgatagttc ggtctcttct acgtatcgtc 84181 caatggatga attaccatca aggatgagtt acctatataa ttacaggttg agtagtcagt 84241 gtccatatag aaattgtaac tttgataaag aagatcttcc gtagtaagat cattcggaca 84301 ggaaaattga aaatcgcttg ggcaatttcg tactaatgta tagcacatgt caatacaagg 84361 tagaatttcg taatagtcat ccaaaggttt aataaattta ttcaaataat cattacggtt 84421 gtgactttta tctctgtgga tgtagtattg ggaagacgtc gtggtgcatc tcggaattga 84481 tactgcacat acccaatcac gataagcttc ggcacaatcg tcacaagtca tgaccggaga 84541 atatcttgcg tctttgtctg cgtcacagga tattaactgt agagctttgc taaaatttgc 84601 atatagtgcc tctgcaatgt ggtcatatgt ctgcgccatg agagttttat tacccacaga 84661 aaatgaggat gtaggaacag agtaagcgac gtcactgcag aagtccaaac caaagatcaa 84721 agagcagaca tcggtacttc ttgtggtaaa ataaacatgt gaaaataaaa tgccgcccac 84781 acttgacaac ccatcaccat tactgatttt ctttgtcagg tacgctacat aagttgttga 84841 ggcattcagt cctgtcacgt aaaacatttc tgtcacgcta ccaccatatt ctgtaatttt 84901 tttttgaatc gccaagtcag tacgctctaa aggatttgta ctatttgacg taactgttgc 84961 atttgatgta ttttgggaag acactaaata tggtccattt ttcacagcac aaagagataa 85021 attatagttt tggtttagtt gaacagaatc ttcgtacgag taaacataca gatcgtacaa 85081 ggatggatca tatattgaat aattgtgata aactttggcg tctgcggtga cattccccgt 85141 tgatagtaat gcagaattca tatcagtgtc caggacctct acccaaggcc ttacatccca 85201 ctgaaaaacc aaatcgttct cagagatact cagtctatat tcccaatttt cagaggcgtc 85261 ggaactggac agaggttgct ccgtagtgga attcactagc tcagcgacca cataaagatt 85321 tgaatacgtg gaggtagcgt tcgagctaga agactgcact ggactgatgg ctaatgcttg 85381 gatgtagcca tcctgaaaaa ctgcactttg acctatattt gggttctcta aaaccgtttc 85441 attaaaagag tagtatattg ttaaatccac atctgatcta ttcatgggca tttggcatat 85501 attgccgcta ataaacatta acacttcata cgtgggagca aacccataac cggaggcttc 85561 tgcgtcaatg gtaaatacaa aactgtcttt tttgcccgct gttatgttag ataagatcgg 85621 ggtccattca taaatgctat ccgaattgat gattgtttgt tgaccagtag ccataacgtt 85681 tttctcccat ctatttaggc tgggaaactt taaggaaata ttcttatttg cgaaaggatt 85741 gaagtcttgg aataaaccgt gaatagaagt ggtaaatagg cagtaaacca cgaatagtgc 85801 ttgccacact atcatcctta gaaataatac tgccgctgga cagaaattgt agtgttacgg 85861 gttttactgc aattcagtat ggcagttaag ccagtcaagt atttgagaaa tagccaaaac 85921 ggtacgtcag ccggtcgaaa ttattaggga aattttccgc aaccaatggc tcagtttcag 85981 taacctgttc ttgagaaaac aacacgttta cttgtagagt tactattgcg gtccgatggc 86041 agcgaaacta tatcattatt atattatgta tggcttctca attttgatct tttttttttt 86101 tggtcagtac gcgattttga aagaaatgga aagaagctat aaagagcaca ggataaatat 86161 cttttcaaag cttgaataat tttataaaag gtgtaggaac aggcccgaca tacaagaatg 86221 tcgacaagta cagagaagag gagcaaagaa aaccttccat gggttgaaaa atacagaccc 86281 gaaacgttgg acgaagtgta cggacaaaat gaggtgatca ccacagttcg taaatttgta 86341 gatgaaggta aattgccaca tcttctattc tatgggcctc caggtaccgg taaaacttct 86401 acaattgttg ctttggcacg tgagatatat ggtaagaatt actcgaacat ggttttggag 86461 ctgaatgcat ccgatgacag aggtattgat gtggtgagga atcaaattaa agactttgcc 86521 tctacaagac aaatcttctc taaagggttc aagttaatta tactggatga agcagatgcc 86581 atgaccaatg ccgcacaaaa tgcgttgaga agagttatag aacggtacac caagaatacg 86641 cggttctgtg tattggccaa ttatgcgcat aaacttacac ctgcgttatt gagtaggtgc 86701 acgagattca gatttcagcc cttgccccaa gaggccattg agcgtcggat agccaacgtc 86761 ttggtgcatg agaagctgaa gttgtctcct aatgcggaga aggccttaat agaactttct 86821 aatggggata tgagacgtgt gttaaacgtt ttgcagtctt gcaaagctac tttagacaat 86881 cccgacgagg atgagatcag tgacgacgtt atctatgaat gctgtggggc acccagacca 86941 agtgacttaa aggcagtatt gaagtcgata ctggaggacg attggggtac cgcccactac 87001 acacttaata aggtacgcag tgccaagggt ctcgcgttga tcgacctaat cgagggcata 87061 gtgaagatac tggaagacta cgaacttcaa aatgaggaaa caagagtgca tttgcttacc 87121 aaactggccg atatagagta ctcgatatcc aagggtggca acgaccagat tcagggcagc 87181 gcggtcattg gcgccatcaa ggccagcttc gagaacgaaa ctgttaaagc caacgtataa 87241 tcgacgcaaa tatgtataga tacaatatgt acagaacaac tgcattgtgc aatataacaa 87301 cataacacaa cgcccagaac gaaataaaaa aaataaaaga aatagatgaa agcattttca 87361 atttgcatac cggaaaccgt aaatcaattg gcgtctagct aacaactgag aatgcgaatc 87421 gccaaattgt tacagaaagt agcattccgt tacgtgatct gtactttaac ctcttggacg 87481 taaagaatgg cagaactctg gctctagtgt tctgcgaatg ccagatcggg aaatatttcc 87541 caaaagggca acagcggcac gaacaagaat ttcgtgttaa aaatcgcgtc cggcgcgaaa 87601 tttttcgcgg aggcatgcga cgcaaaagcg actcgaaatg tcgggagcca aatgaggcta 87661 caaggctgtg ggcagatttt ggcgttatta tggagaataa aaggaatggt agcttccata 87721 tagcgatagg aaaacatata taaggtcaat aggcctacat ggtaatggga ttgataagct 87781 tgtccttaac tcttgtgtct tggaattact attgcgtaca tcagcaatca tccattgtca 87841 agaacaaaaa cgataacaaa aacaatcaat tatacaaata acagtaaagt aataaaatgt 87901 gtgaatacag caaggctctt catattctgc tcaagtcgcc agtaacggat gacataataa 87961 aattcttaac agacacaaca ttgagggttg ttccttcaag caactacccc acgcctcccg 88021 gttctccagg agagaaacac ctcacaaggc tgccatcgct aatgactttt atcactagat 88081 tggtcagata caccaacgtc tacacaccca ctctgctcac cgctgcgtgc tatttgaaca 88141 aattaaagcg tattctgccc agggacgcta ctggtctccc ctcgaccatc catcgcattt 88201 tcttggcctg tttgatactg agtgctaagt ttcacaatga ctcttctcct ttaaacaagc 88261 actgggctag gtacaccgat ggtctcttta cactagagga tatcaacctt atggaaaggc 88321 agttgttaca gctgttgaac tgggacctca gggtgaacac agaagatttg atcctagatc 88381 tgcagcctct attagagccc atcaagcaag acttggcaag atccagcgac caaaggaaga 88441 gaattaacat gatgatgtcc atgaacagaa ggacttgtgc tggcacgagt cctatcagat 88501 caaacaacag attcaaactc tacgaaaaac agagaaacgt gtcgatagca tccgatttaa 88561 gttctgctac tctagtcgac agttgtaatg atctaagaag gctaaaagat gtaaccaaca 88621 tagcgaacaa cacagtcgct aacacgaatt acgtcaggac ggtagagaaa tggaacgaca 88681 atgtcaacag gcaaagttgg gatctggaac agatcatgag tcaacatggg ttttaatgtg 88741 gtaaacaaga tggcccttac ggggctctta gtgggagaaa gatttttaat agagcataat 88801 taacggatac ataatatatt ataaatttaa ataatcaagg atacctaata ataataacaa 88861 tcaactgaac acaacattaa aaatggtatt tgttattgta tgttaagccc taagtgattg 88921 tgccgttata acttccattc gggtgatacc tgcaatatga ggaagaaaaa agataaattt 88981 tttcttctta aagtataaaa ggcggacata tttgatttaa atgcagaagt tttctctcag 89041 tggtttatgt tttacatatg atagaaaaaa tgaagcaata gcaaagtatc gtagtgcgaa 89101 ccggtctcgt aactttgata agtttatcaa aggcgttaac attttgtttc gtaatagtac 89161 cttaacacat gacgaagatg aaaattaaac atgaattcaa ggaaaaatgg taaatgacga 89221 gaaaaaagct gtgcaccagt ctgaacatgg atgccacaag tactcaggtg tcctatgaag 89281 cattaagtat acccaaattt ctgatccatt ttcctttatt ttcttttttt tttttctctc 89341 acatctgtga ctgtattatg agcaaactgt ttacgttgaa cggaatcgat atgtaaatta 89401 aatcttttga aatatgtagg acagtgcttg tataggtctg ttaagtagat tatagaatgt 89461 acgccttttt tctgggcgtg aaatagatca gaaatcctgt taggttgcca ctggtccatt 89521 tcagtgttgc tcatccaatc aatcatgtat ttacatgcct ggagtggcct attctatgta 89581 ttaacagcct ttgcaagacg cgacattgtt ctttccgata tggctcggag tagactaaat 89641 atgctactta tagtttttct tgcgtatacc attgtcttat agtttttgca cacattaatg 89701 tttaaaattg aaactacgaa gcaaaacaat aaaaaaaaca aacaaaactt aaaaataaac 89761 aaaagacgct cgaaaccaag tgcatttatt gaatgttttt gggaatgcaa gtagcaatac 89821 tattgtaaaa gtactactat ttccctgtat catacgcttt tactactatt cctcacataa 89881 agcgagatgc ttacagaatg cataagagag agaagaaaac cctattacgc ccacttgtct 89941 atattagatt actgtcccta tttatatcat cattgcaaaa cgtgagcacc tcattagacg 90001 tagattcttg cataagtatt actagcagga gaggaaaaac tccacccaca cacctcaaca 90061 tgctgagaat tttgctgcga gcagcaagag gcaaaatcca aatttaaagt aatttacgca 90121 tagaagacat tgtaaaggga ttgcaaagac gtagagtacg caagttagaa accgttcatc 90181 ttttaaaact cccaagtttt gacaaatttg cgagtgtgtg tgtttctgct gatcttgacg 90241 agattaaact ttgttcctga agcaacaacg acagcaactg aacatcctct gaataagtta 90301 atatgttttc cgctcaaaag ccaatatatg gcaatggagc aggcgtgaac atgggtggtg 90361 gtggtccttc aactaataat ccaggatcta tgtccatgcc tggggttcca acttcaatgg 90421 gtccaggcat gaatcaacaa attccaagtg gaggccccat gctaatgggc aatactccga 90481 ataataataa tagcaatgaa aatggcgaga acaacggcaa taacggcaat aacggcggta 90541 acgatgctaa cgcaactcga aacaatccca acatggtcaa taatagaggc gcagtgcatg 90601 ctctagatga tcccaatgta taccactgga tttgtcaatt gacctacggc cctcaaaagg 90661 aacaagcact gcttgaatta ggtcgcaaaa gagaacagtt tgatgacctt gccgttgtgc 90721 tttggtcttc ctttggtgta atgacctcat tgctgaacga aatcatttcc gtatatccca 90781 tgctgcaacc tcagatgctc tctaacaatc tatcaaatcg tgtatgcaac gctctagttc 90841 ttctacagtg tgttgcatct cacccagaga caaaacatct ctttttacag gcccatattc 90901 ctctctttct tttccccttc ctaaatacta cctccaggca aagaactttt gagtacttga 90961 gattgacttc attaggtgtg ataggcgcat tggtcaaaaa tgactcacaa gacgtaataa 91021 cgtttttgct aagaaccgat atcgtgccgt tatgcctaag gatcatggaa tcttcttctg 91081 agctttccaa gacagtcgcc attttcattt tacagaaaat cctactagat gacgttggat 91141 tgcaatacat ctgtgccacc ttggaaaggt tctacgccgt aactaatgtc ttaaaagata 91201 tggttgagca cttgaccgtg agcacaccac cgggacgact actgaaacat atcattagat 91261 gctacttaag attaagcgac gatctcgaag cacgcaggct attgaaaata gtcttacctg 91321 ccaaactgag agataacact tttacggaag tactaagaga cgacgtcggg tccaagagat 91381 gtctggcaca attgctactg acattaaacg aagaaacctc atgatgcatc cccatagata 91441 tattactgtt tttctctttc tattttcctg tattgtttta accttgcctt tttgttttag 91501 tttcacttcc tcacctctcc taattttgta tagttatatt tatatgcatg aaatgtataa 91561 agtccactca tatttcagaa tggtttaagt taagtgccag aaggttcttc tgtactatta 91621 ctattaccca tttttcatcc tatcacccgg aatgtacccc ttgtgtcatt cactacgacg 91681 ccacgaacca cgattctatt tttttcgaaa tctaaaggtt tcgtcaagat caatgaaata 91741 tacataggcg tttttttgga tacgagttgc attgttgaga acacaattct ttacaaataa 91801 gtgcaaggga ggaattgtgt gtgctcatta ccaacgtact tcttcagtta ttctgctaaa 91861 cccgtttttt tgttcttagc ttcatccagg tgagcccgca aacattacag aacgacgtat 91921 aatacaaaat aactaaacaa atacggatag gacaaaagcc aagaagcgat actaaatcac 91981 agagcgaatc aacatgtctg cacatactta caaaaagttt gaaaactcga cctcgggcga 92041 tttacctgat aaaatgacca tttatcagga ttgtatgaac acgtttaacg aatcacctgt 92101 caattccaag agatgtcgtt tattgatttc tcgcttgctg agactcttgg cccagggcga 92161 aaccttccca cagaatgaag caactgcatt atttttctct atctccaaat tatttcaaca 92221 ccagaacgat cctttaaggc aggctgttta tttggcaatc aaggaattga gtggcatttc 92281 ggaggatgtg ttgatggcaa cctcttcaat catgaaggac gttcaaaacg gttccgattt 92341 gattaagcct gacgctatta gatcgctgac ttatgtcttg gatgaatcta ctgctttttc 92401 cgctgaaagg ttattaaaaa gtgccgtggt aagtagacat ccttcaatat cctcagcagc 92461 attatgtact tcttatcatt tgctgcccat ttcagaagtc actatcagaa gattcaccaa 92521 tgaaactcaa gaagctgttt tggatttgaa acaatttcca aatcaacacg gtaatagcga 92581 atattatcca aactccactt atatttctca atatcatgct cttgggttgc tttatcaact 92641 gaagaaaact gataaaatgg cgttactaaa attggttaga catttctctg aaaacaattc 92701 tatgaaaaat caattggcca aggtagaatt ggtcaagatt gtcaacgatt tgatttatag 92761 ggatcctcaa ttatttagtc aattcaggcc acttttgtct gattggctat ccaacaagtt 92821 cgaatctgtt cagttggaaa cggcgaaatt gattacttct ttcgctactc gcaattcccg 92881 cttagtggct cccgagttat atgcggcagc tatcagtgct ttacagtcct tactgaccgt 92941 tcctcgtgtt tcttctagat tcgctgcatt gagaatctta aatagaatat ccatggtttc 93001 accagaaaag attgttgttt gtaatcctga actagaatct ttaattaatg attctaatag 93061 aaacatttct acttatgcaa tcaccacttt attgaagaca ggaacttcca aaaatatttc 93121 atctctgatt tcgactatta ctaattttat ccatgatgtc agtgatgact ttaagatcat 93181 tattattgac gccgttcgta cgttgtcttt gaacttccca caggaatgga agtcaatttt 93241 gaacttctta atcgatgttt tgaaaaatag tgaaggtgga ttcaaattta aaaacagtat 93301 tgtcgaagca ttaatcgata ttgtttcatt tgttccacag tctaaagaac tcgccttaga 93361 aaacttgtgt gatttcatcg aggattgtga attcaacgaa atactagtga gaatactaca 93421 tcttttgggt aaagaaggtc catctgcccc aaatccatca ttatatgtta gacatattta 93481 taacagagtg gtgttggaaa attctattat tagatctgct gccgttgtag ctttatctaa 93541 gtttgctttg acgaagaacg atcctacctt atatgagtca atcataagtt tgttaaagag 93601 aatcgctaat gataaagacg atgaagtcag agacagagcc accattgcac tagaattcat 93661 tgattcggct aggaataaag atgatgttat agcacaaaat ctaatcgaat ccaaatattt 93721 ttacgatatt ccatcattag agtcaaaatt aagttcttac atttcctcaa atactgattc 93781 atttgcaact gcatttgatg tgaatcaagt tcgtaagttt actgaggatg aaatgaaggc 93841 aataaatctg aagagaaagc aagaacaaat tttcaatcaa aagtctgaaa ccactttgga 93901 tactacacca gaggcagaga gtgttccaga aaaaagagct gacgctaatt catttgctgg 93961 tccaaacttg gacgaccacc aagaagatct actagctact aagtacgctg acgaattgct 94021 atccattgaa caaattaaac catttggtca attagtaaat agttctaggg ctatctcatt 94081 aactgagcca gaagcagaat tcgttgtacg tggtgtcaaa catctcttca aagacaatgt 94141 tgttttacaa tttaatatta cgaatactct gacggatatt gccctagaca atgtttctgt 94201 agtctgtacc cctgaaattt ctgatgaagc tgaattagaa gagctattca ccctacaagt 94261 ggacagatta ttaccatccg aggaagcagc ttgttacgtt gcattcaaaa aacttgatga 94321 aattgtaatg gaaggtttct tgaacaactt aacattcact acaaaagaaa taaaccctga 94381 cactaatgag ccatttgatg gtgatgaagg tttccaagat gaatatgaaa ttgactcgat 94441 tttcttgaat gctggtgatt atgttaagag ttctttcact ggtaacttct ccgctacatt 94501 tgatgagttg ccatgcgaag aagttgctgt tttcaacatt caagaagatt tatccataca 94561 agaagtagta gataagatta ttttgaacag tagctgctta ccggtggaaa gtacccaatt 94621 tgctccaagt gattcaaact cccacacctt gaaattattt ggtaagagtg ctttaactgg 94681 atctaaagta gccctacaga ttaagatgat caagagttcg aaaggtcttg ctttgaaagt 94741 tcatggtaaa ggtgaagaca gcttattatg ctctgatctg gtgaatggtc taatgcagta 94801 agctgtgaaa ttttatttca gttaatccct tcttttgtta tcaatagtat taaaagaaat 94861 gcgtcagctt tagcaagcgt gcatgcaaat aagggaatga acagcaagaa caataataaa 94921 ccaaaaaaat cacggataga atatgacgga tcatcaccac acgaagaata aattatgtaa 94981 tctttgtata aacaaaattt ttaaagaaaa atactataat agtttgacaa gagaaaacga 95041 aatggaagaa acaggacaac agggcagaaa aaagttgaca ttatgcaatt gatgaaagaa 95101 gaagaagaaa aaaaacaaaa aaaaagcact agtctgacca ggcatattgt aaaaggctgc 95161 agacccttga acgcactaca cttttcactg tattccgtta ccaacattac tgtttgacag 95221 cgatggatgc tgatgaattg gaattgaaag gtcatttgaa aaaattgaaa aaagaagaat 95281 tgcttagaag gaaacagtta aaagagagta atcttcagaa aagagagctt gaatataata 95341 atgcctcaaa aaatacttca atatatattt ctggtcttcc cacagacaaa acaacgaaag 95401 aaggactcac tgagcagttt tgcaagtatg gaatgataag aaccaatcga gatggggaac 95461 ccctttgcaa gctatatgtg aatgataaag gcgctttcaa aggggatgcc ttgatcactt 95521 attccaagga agaaagtgtt acattagcaa tcgaaatgat gaacgagtcg atcttcctgg 95581 gaaaacagat cagggtcgaa agagcccaat ttcaaaacaa ggaaggtgac aatatgcacg 95641 ggaaagaaaa tgatttaaag gagttcaacg gacctgagcc tccaataaag aggctaaaaa 95701 aagcgaagtc tgaaggggag ggggaagtaa tagattacaa tgacgatgaa agcctagcaa 95761 aagctgatcg aacggtgata tttgccaacg tattcaatat ttacaaatca tacacaaatg 95821 atgatataaa tgatattcag gaagatcttt tggaaggctg tgaagagata ggtcaagtag 95881 acagtatatc tgtatctccc aataaggggg aagcgacggt cgtctttaag aacaataaag 95941 ttgcattgca atgttgcaaa atcatgaccg gacgttattt tgatgggcaa aagttgcttg 96001 ctttcatttc tggagatgag aacacttcaa gcacaagtga caagaatgag gacagcgaag 96061 tggaagatga ccttatatag aactgcagta aaaaaatgta ttacccccat atctttggta 96121 cttaagtaaa ataagtgaac acaatgtaat aaacagaatg gattagggct ttatgacttc 96181 ccagtacaaa ataaatgtcg atataatact tgaaaatgca agcaatgcca tcaaaaaatt 96241 tgagcggtac gagaatcgaa cccgtgtccc caccttggaa gggtgggatg ataaccacta 96301 cactaaccgc ccatgtgttg gatggtgtaa ctgtaatgac gaggtaataa gtgatggcga 96361 ctatatcacc accgaaacac agcgattact taaaagggta atcactactg cgattctaat 96421 tgttggaata aaccaaacct cttccgataa tgttggaacg agagtaatta atagtgacat 96481 gtgttgctat ggtaacaatc taatgcttac atcgtatatt aatgtacacc tcgtatacgt 96541 ttaagtgtga ttgcacctat tgcagaagga atgttaaacg agaagctcag acaatactga 96601 agctgtgttt gagaaatggg tgaatgttga gataattgtt gggattccat tgttgataaa 96661 ggctataata ttaggtatac agaatatact agaagttctc ctcgaggata taggaatcct 96721 caaaatggaa tctatatttc tacatactaa tattacgatt attcctcatt ccgttttata 96781 tgtttcatta tcctattaca ttatcaatcc ttgcacttca gcttcctcta acctcgatga 96841 cagcttctca taacttatgt catcatctta acaccgtata tgataatata ttgataatat 96901 aactattagt tgatagacga tagtggattt ttattccaac ataccaccca taatgtaata 96961 gatctaatga atccatttgt ttgttaatag tttgaatgtt tttatcggaa gaggtttggt 97021 cattacgtct gcaatattct ttttggtttc gatatagcat acgtgcagat gatttcctga 97081 tacttcatct ctcaatctca ttgctttagt accaaaaaat ctgttcctaa atttctcttc 97141 attattggat ataattatac tgattgtaga tttactgtcg gttagtaatc ctttggtaat 97201 tggtttcttg tcaagttctt gtatcaggta acttagatta tttaataatg ggacagattc 97261 acttatcgcg tgtatttctg cttccgtagt tgaagtacat gttaatgaag ccttggtgga 97321 ctttcctcca attacctttc cattaagtaa atatatgttg ccaatttgtg atttataata 97381 cggttggttg ccatacgagg catcgcttat aacaactaat ttatttgttg gcttaacagg 97441 tttgcttttg tgccatatta attgcttatc tctcgtattc catatgaact gtatcaattc 97501 atatgtcata tctaacactt gcttggacgg aaatagtata tgttgtgcaa gtgtgttgat 97561 gtagtataat aggtcaaatc taaatttata tccaacatat gatgctagac ctatcagctt 97621 ttgcatttca tgtaccttca ttttgtaatc atcttcttct agctctagtt cttgctggtc 97681 tatatataga cctggttgac ctggagcact aagtttcctt ccttttgggt ttaaaggtac 97741 gtttagtttg ggtatttttt cagttaatga gttttccata cccaatttca tgtatttacc 97801 tctttggtat ttgatttcca agccaagaat gtcatattga atttcctcat cactttcgcc 97861 tagatttata atcttggtgt cgtattgcat cttaagcttc tctataattc ttttgtttga 97921 atttagattt ttgctaaaca ataccatatc atctacgaat aaacaaattg tcacttgact 97981 gtttttaaat acgcatgacc atccacgaac ttcttccata ccacattgtt gtatcaggta 98041 tgatttgata gtttcgtacc agttcgcacc actttgtttc aatccataaa gcgatttctt 98101 caaacgtatt aacttatcat tcattcctaa atgtggtgga ggtcttatgt ataattcttc 98161 tttgatgtct gcatacaaat atgccgaaga tatgtctaat tgtgtaatat agtagttatt 98221 gtctaatgca agtgacaggg atgtcattaa tgcatagtga tgtacggtat tggattgcat 98281 gcctgagtcg taagtgtcag gatgttgaat atcacctctc gcaacaaatc tagctttatg 98341 agtaccgtca cgtttcctgt taaagataaa cattgaattt attactcttt tggggtctat 98401 ttcttttctg tcataatatc tgtcagtgtc ccaagttttc atcttcaaca gttggttgac 98461 ttctttgtgg tatgcttcga tatatttttc tttttcttta atatctttat tataggtgat 98521 tgcctcatcg tatcgtaagg ttgttcgtat tggtttgatt gattttactg cttttacagc 98581 tgcaatcagg tgaattcgtt tcttcgatct cggaggttct aaactacgca tattcttagt 98641 attccatgtg tctcgtgata ccttaatttc agtttcatta tcttctaatg atcttttctt 98701 actgttgata gtagtatagg cattagagtc accaatacca cccaaactgg aattagtttg 98761 acgagaattg atcggtggaa gttctttaaa ggagtctgat aatttggtag gaggttctgg 98821 aggcagatcg ggaagtggaa gatcagcaat tatagattcc tctgtattct ccttaggaca 98881 ggtatctgac gttttgatag gaacgacgtg gtgtagtgaa ttactttctg atgaggaagt 98941 atcgatcgaa ggtgaacggt gtataatcct tttctcagtc tcctgttcgc ttgtctgcgg 99001 aacagtttta ttattggtac cacccgtact ggatattggt acgtttgtat gattagtctc 99061 attgtcactg tacgagtctg agtgtctgaa atctttagat ttactggtgt gcgacgattc 99121 atgtgtgtta tattgggaca tgggagcaag taaaggaaca tctaatctat gcataccacc 99181 cgaaccagta ctctcgatat cggaaatttg gggggtgcta gatctcttct ttgatggaag 99241 gatattagat ttagatatgt tgggatcaac ttctctgggt gcgcgaatat tggttttaga 99301 aacacgtttc gaatcttcag tatgagttga cggaggtgtg gaatcggttg gactcacagc 99361 ttttgaaagg acatttctcg gttgctcagg atgtagttcg atgtcagatt ggaagtcatg 99421 gtcagattct atgttaagat catcggattg ttggatctca tttgacgcaa tgaacgattg 99481 atatgaagca gttaaacggt ttaagtcttc atcgaaagtg agtgcgtcgt aattgaattg 99541 atctaatctg gattccttgc cctgaagaat aacatagtta gttgtatcta ctgtcttctt 99601 taaggatgga agatagatga tatatccata agagtttcga gacggatgta gagcgtagcc 99661 tgggatgcca cgaggatgta ttttggagtt agggttgtga tcattgacga taacaggttg 99721 accgaaaggt aacaaagtac tgatatcaag tcctgccaag ccagcatgtt gtcttgcaga 99781 ttttttgctt ttaggtgaag ctagtgaatt tctcacaata gtagaaaatt cgattgcaga 99841 gaaccataaa tggttcggta aaccactaca ttgcagttga gtacggcagt catctaataa 99901 ggtacggttg agccgttcag cgactccatg tgctcgggaa tccgctgtgg ttgtatagca 99961 tggagttata ccattttttt caaggaattt atggagagtt ctgttagtat actcagaacc 100021 acggtccatt tgtataacca agacactggc ctgaaactgg ttcttaataa aagctagtat 100081 cgtagtaaaa acatcgagga tagagtcctc gcgacggtcg tgtaatggat aaacccaacg 100141 gaattttgtt gtctcatcag taaatgagat gaaataggat ggtgcacttt ttggtaggtt 100201 gtgaactgga ccaaatatgt cagtatgtag gtattgaaag ggttcgtatg aattttggta 100261 ttttagtcgt gaacctttga tatgtctgtg tttggtgctt ttgccgatta aacaatcagg 100321 acattgatag tcaatagcac tagaccagtc gacatctgat tcgttaaaat acgtgatggt 100381 gttattttta agtgagtatc gaattgtctg tgcattggca tgtgcaagca ttcgatgaat 100441 gaaaggataa ggatatttgc gtgtactttc acttgtatgg acattattga tggtgggtac 100501 ggagatattt gatggaagca agtacttttt agatacccag taaaagtctc catattttac 100561 gataggtgca agtacagtgc cgtcagatcg ttctaagacg tttttggtaa agcatgctgt 100621 gatatctact gcagccaatt cattcaaact gagtaagtca taggctatgt taggagtgtg 100681 caataccttt attgatgttt tggtgttgtc ctggaagtga aattgtaggt caccaatagc 100741 gttaattggt atatttcttt tttgagcatc aactacgttt atgccaggat tagatgatgc 100801 tgagtgtatg tggtgagcag atcttataag ggttcgtgat gctcctgaat cgagaaggag 100861 gtgtccaggg agttcatcat cagaatgatt agtgtgattt accgtagatt cagtaagttc 100921 ctggcctaag gtgaaggtcg tgtttattct tcaattgaat cggttcagta gttgatcctc 100981 ttatgagatc gttatcaggg ccggaagagt tattagatgt ggatacgtta tgagccctgg 101041 ctgttcttga ttgtgaatta tttggttttt gggaattccg agttatggat ttgggtttgg 101101 ttgtattcgt gtaggtgcga gagtctttct tctcatcact cggatttctc ctataagtag 101161 atttattacg ttttgattcc tgttgttctt catacataga atgtatgtct gaaaacagat 101221 cagcaactgt catatgtata tatcgatgac gtgcgtagcg taaaaatttg tactcgccag 101281 atagacctct cataatgaat tggcatgcta ccttgttatt gataggaatg ccattgttgt 101341 ttagtctgtc aagaatgttt gtgacttctg cttcaaatgc atctgcaggt gtgcttccat 101401 tataatgcaa agttgctagg gtcgtaatgt catttacctc ttgagtatca gattgcattt 101461 tgttaatgct tttggaaaga attttcatga tatctgtata atcagcagat aagatgtctt 101521 taacccaggt gggtaagaat tgagatggag caaatagttg aaaggtgtga cataagaagg 101581 tgagttcgtc atcagtcatc tgacgtacgg cttttcttgt tgctgtcgga ataatatcac 101641 cgagattcga attttgtaaa aatttgatgt atgttttaac ccaatttaga aagtcattag 101701 gtgaggttaa cattggtggt ggtctgacat attttttagt ggatgtcata tcagagtccg 101761 ctgaggatga atcagtaaat gtattacctg actcaggtga tggagtgctc agaggcgttc 101821 caactgatga tggatactgc ggaaactgtg aatgtggccc aggtggaaag tacataggcg 101881 acatttgata aggtgtatac ggaatcatag atgggcgtcc gtaaaatgac caaccagatg 101941 gattggcttg gttttgggtc atcatgcact gctgttggta cggcccattc tgtggtgaat 102001 gtgactgagc agtttgagga gaggcatgat gggggttctc tggaacagct gatgaagcag 102061 gtgttgttgt ctgttgagag ttagccttag tggaagcctt atcatattct tgaattttgg 102121 aagctgaaac gtctaacgga tcttgatttg tgtggacttc cttagaagta accgaagcac 102181 aggcgctacc atgagaaatg ggtgaatgtt gagataattg ttgggattcc attgttgata 102241 aaggctataa tattaggtat acagaatata ctagaagttc tcctcgagga tataggaatc 102301 ctcaaaatgg aatctatatt tctacatact aatattacga ttattcctca ttccgtttta 102361 tatgtttcat tatcctatta cattatcaat ccttgcactt cagcttcctc taacctcgat 102421 gacagcttct cataacttat gtcatcatct taacaccgta tatgataata tattgataat 102481 ataactatta gttgatagac gatagtggat ttttattcca acagtgttaa agatctatta 102541 gttgatcatg ttggaataaa aatccactat cgtctatcca aacaattctc tcaaaattcg 102601 cccaattctc aaaattcacc catttcccac acatatgtgt tttaggaacg tttaggataa 102661 ggaatcgtca tactgacgta cctcattttg agatacaaca aatcatatat tataagactc 102721 catggccaag ttggttaagg cgtgcgactg ttaatcgcaa gatcgtgagt tcaaccctca 102781 ctggggtcgt ttattttttt tgtatttgtg cttatttact aaataaccat ttcaccctgt 102841 tataataatg cttaaaagaa gaatgtagtt tttctctttt cctttaactg ctttacttct 102901 cccgaaaaag caagatgcaa tcttttaata tgtttgagtt tgcttaaagt atattcacaa 102961 aaaagaaaat aaaagttaaa aatttctgaa aatcaggacc ttattcgata gttggtcata 103021 aattgactga aaaatagaat aatttcggac accaaatgaa tcattaacaa gacaatatct 103081 taaggtatgt acaagtgaga atattactta tatataaaac ggttaacaat tttttagtgg 103141 tccaaagcct tgatgttcat gactttagaa ttagacacaa ctggcaccca atccttctct 103201 ggagacagtt cttctagctc tatttctaat gagctctttt ttacattctg ttttaaaaag 103261 tgtctagaac ccttattttg agcttctttg atatcttgta agagtttatc tttttccatt 103321 actaggtaac ctcttttctc ttctttacta tagaaatcaa tatcccttct tttcgtgggt 103381 ctagcctgta gtggtactct tcccctcttc tcaagaaacc actgggggtt gagatgtgcc 103441 cttagaccca acggtgtgta gtaacgagct gtaaacttac ctcctgcttt ttcaatagcc 103501 gcaatagcct tagcggatgc tctagaagcc tccaaagcaa tcggtagatt gtagtggaac 103561 tttccgctgg ctagaatttt aactccgtac tttatgggac cagttaccag accaagcttt 103621 ctcatcttat tcatgtctaa aacctcgcct ggttgcaaat gaagcctatt tttatcatga 103681 aaccattgaa tgcgtttcaa gtttaattcc tttaatggtt tggcgccaac gttggtaaat 103741 ccaattttag gaaatagctt gtaaattgga gtttgaccac cttcaaacca cgattttact 103801 ttaccacgcg ccttttgacc cttttgacca cgccctgatg tcttacctaa accgctggaa 103861 ggaccacgcc caagtctttt gaaagacttt gtagaaccat ctgacggttt caattgtccc 103921 aaaatcgaaa cataacgata actttgaaat gctaataccg gcgatttgaa taaacctcgg 103981 aaaaaaatat cgttaccagc tacgctagtt aacatcatgg acggaacaaa agtgtttatt 104041 agtttgcgac cgattacggt tgtaaaacta tttcttaatc ctgtttgcct ttccgctttc 104101 atcaacttct aaaggtcatg agctttaatt ttacgcactg cgtttagtgc agttacctgg 104161 agtttcagcc gggtaagaaa actatacgat tgccaaatag aaaaacggat ataaagatag 104221 tagctgtgaa tagtagcttt gtatagtaca taaaggtacc ttatctaaca ttgcttgcga 104281 cgcagaatac gcaaaatata ctgtttaatt gcaatcagga gtttgctacg gtatttggta 104341 taatcggaac tcatattgtc ctacgttcac cgagaccaat gaacgcacaa taaaatggat 104401 acttggaatg ccctacccaa aatatgagct gcgtttgttt tgtgaaaaac gaaaagtaat 104461 taagttgttt tgcagaagtg tgaataattg ggggacgcca tttggtttct ctcttctgat 104521 tgattaaagt taatttcggc acaataaccc aatgactggc taggaaactt ctcgatgcat 104581 ccgtgatctc ccaaggacga aatggttttt atcacgtcct aacgacatca tatgtcctcg 104641 aggagaactt ctagtatagt atttattaac aatggaatcc caacaatcat caaattattc 104701 accaaatata cacagattct tatactaact aaagtaagaa gattaggatt tccatactca 104761 ttttgttaag tagcacttgt atatccggtt ttctcaagtt ctgagcttct atggccaagt 104821 tggtaaggcg ccacactagt aatgtggaga tcatcggttc aaatccgatt ggaagcatat 104881 tatttttatt ctacggtaaa catgcctgat ggtgatttga gacagacccc attgcctcag 104941 atttgtgaag aatagaaaat gtgtacattc attttgataa actatacata tacttaactt 105001 tttaacatga taaatcaata ttgatatggt cggtactgtt cactttatct atattttttt 105061 tctttcgtgc aataatcgtc ggctttaata atattataca tacaaaggga aaatgaagga 105121 aagaaatatg aaaggatgaa taagtctttg atatgaatat gtagtgttgg tatctaaacc 105181 tagtcagcgc aaagaactat tattggaatc ctttgcatca tcgtaatcat catcaccatc 105241 tgagacatta ctcccaatat ttgaactcac attatcgggg ttgacaatgt gtagttgtct 105301 ttcttccatc atatcgggca gcgaagtagc actgaacctt tggttcccgt tatagatcga 105361 aggaggctcc tcgtacacta ccgagggaaa gtgacttctt ttgctgatat tatgtgcatc 105421 accagtaata atagaatctc tgccgcccgg cgcccttgtc ggcagatcat aagtggcaaa 105481 agtagacgct gtattcttgg acaatgctgt attattccta gagggtatgt gccagttagt 105541 gctcgaagca gacggtggaa taacagggtt agcgtcagca tcacccagtg agtacggctg 105601 gtactgcttt gtctcttcca agtccacatg ctgagaagat tggcgacgtt ttttccatac 105661 gaaaaagaat aacgccagag ccaacaaggc aactgtacca caaaccacac ctactacgac 105721 acctgcgatg gcgccaccac tcaagccttt gctcttggac gagctcgatt tcccgtttaa 105781 gagagaacta gtagaggagg acgtagacga tactgttgca taaacagagg tcctggtggt 105841 aaagatcgtg cttgcttgtt ggttagcttg agaaaccacg gactgcgtca ccacacgggt 105901 agtgtaatgc gtggaagtac ctattgaagt cgatgagggg gtagaagtga ccgttgctgt 105961 cgaagttgag gatgaggtcg atgtggtgga tgaagaagtt gcctgcgtag aggacgtttc 106021 tgaactggaa gaggcagaag tgctagagga agtggtggaa ggagaagaag aagtagaagt 106081 agtactagag gtagtagaag tagtagaagt agtagacgta gaagaggaag aggatgaaga 106141 agaggaggaa gtagttgtct ctgaagagga agtggtagtg gaggttgtag acgaggaaga 106201 ggatgagtgc gtagcagaag aactagttga agttttcgtg tccaatttcg tggacgtttt 106261 tgaactaaca cttgtgcttg atgaagatgt tgtcgatgtt gaggtagcag tagatgaagt 106321 tgagtccgcg gtagaagcag cgttattgat ataaacgttc atggcagaag aaccaccaca 106381 attttggtag ggccagccag cacacgaaac atcacatttg ctcgaatcta cctgcgtcaa 106441 agactgtaac tgagctacgg aaccaccaca gtagcaacct gtaccgttga aaagagcaac 106501 gacagcctga ccagggcatt cattttgaca gtaggaaact gattgatact cgtaaacacc 106561 cttgtaagtc aaccccaatt ttcgtatatc actagctgaa tagcaagctt tatatgtgaa 106621 ttggtcagcc aacgcggctc gtatatatat gagccacact aagatgaagg acttgtgtat 106681 gagatctagg tgcatattcc acttctataa tgctgttggt caaaaagaaa ttcaaagaag 106741 aaacaattag aaaccagaaa gtctgtaaaa atacaaaaaa gcgtgtccta taaccgaaca 106801 gcaatgtttg ttttcactag atttgttttc ttttggcgaa aaacgaaggt agaaatgaaa 106861 gtaaaaaaag agcaataatg gtaaatcaaa ggctagccac gctttgagct atagttggtc 106921 gtgctgagca atagtaaaga attgaaaaag cgagtggatg atttgaaaac tgcttatatg 106981 ttttacgttg agggtttctc ctctttattt cttcgaagga cggaggacag gtataaagca 107041 gtcgctggaa ctcttttccc tgacaatctt aaaaagaaag accgaaacag agtgttataa 107101 aacgaaacaa aaaacctgct gtaaatgcac ttctgggaga agtgctagat cacaacatac 107161 aaacatatgc aaattcatag taaaaggaga tagggcccag atgaccaaat caagaatggc 107221 tcactgttga aacattctgc ttaatgtcga aacagtccgt aaacaaacac attcccacaa 107281 aacaccgcac cgcgaaaaaa aaaaaaaaca ggaaaaaacg cgaaatgtcc gtaactttac 107341 ccggtaatag tcacgtgata aaggtgcatt ggtctagctg gctgttctgg ccaacgcgac 107401 agcagggttc atactttcag tagaacaaaa atcgggggaa atgcgatgca ctctttaact 107461 gcaattatgc acatcctatt gccagggcgg atatttgatg ttgttctcag atatgtattc 107521 cctgatctat accgttctca tagttcaatt ttctctgatt ttctcgtgcg ggcaataagt 107581 aaaaaatagc atttgcgtgc ttaagtgaaa tttttcagat tatgagtgat atagagatga 107641 ggactgtaac aagaaggaag gtgaggaaat caagacggta agtagcatgt ccgggtcgtt 107701 aaaatctcta gacaagaaaa tagctaaaag aaggcaggtg tataagcccg tgctagacaa 107761 tccgttcaca aacgaagcac atatgtggcc gcgcgtgcat gatcagccat tgatttggca 107821 gctgctgcaa tcctctatca taaataagtt gattcacatt caatcgaagg agaactaccc 107881 ttgggagctg tatacagatt tcaatgaaat tgtgcagtat ttgagcggcg ctcacggaaa 107941 cagcgaccca gtatgtctat ttgtgtgcaa taaggaccct gatgtaccgc ttgtgctctt 108001 gcagcaaatc ccgctattat gctatatggc gcccatgacg gttaaactgg tgcagttgcc 108061 caagagtgcc atggatacct tcaagtcggt ttctaaatat ggaatgctgc tgctgcggtg 108121 cgacgatagg gtcgacaaga aattcgtatc gcagatccag aagaacgttg atctgcttca 108181 gtttccctgg ttaaatgcta tcaagtatcg gcccacatct gtcaagctgt tgaaaactac 108241 agtgccaatt gtctcgaaga agaggcaaaa gtagacaaaa ttacccgcgc aggcctattt 108301 ttctagaaga cagaagaaaa aagtgggcag agaaagcgag gaaaaaaaga aatacatatg 108361 aagaagaaaa aagctgaaat ttaagcaaat actttttgga caaaatcatc aaactactac 108421 taaagtttga aacgatcgga aagttacaac acatttacga taaaatatgg ttgtcttgaa 108481 tccaaataac tggcattggg tggataaaaa caccttacct tggtctaagg actacttgaa 108541 cggtaaatta acgagtttgt ccactgtttc ctctgatggg aagagcaaaa ttgagttaac 108601 ccaggtgagt agcatcaccg gtgactccaa cgtatctcaa aggaagggca agccgatttg 108661 ctactttgac ttacagttgt cgatgaacgt caaagtgaca aatttggata ctaataagga 108721 cgacgaggat gatgacggca tacttgcgga cgggaaacta gaaattccag agtttatgca 108781 tgacgagtct gatattccga ttttgtcgca agggtttgat gcttttgatg gattggttag 108841 gtctgaattt gtccctaaag tagtggaaac gctactaaaa taccaagatg acttgattaa 108901 agaacactca aaggatatac aagtttgatg tgttcatgta acgaaaaggg gagcgttgca 108961 tagatagacc accgcccctt ttaatttttc cagcgttttc aattgttatt cttcttcttc 109021 ctcatactca cccaatacat aacatgtata cacacataca tagataatga agaaaatagc 109081 agtggtagaa aaacttaata aacatatgga atgatcttgt aaggaacttt tctttcgtat 109141 tcttcccaat tttcgccata tttcaggcgg cacttgtgct catcacgttg ttgacggtgt 109201 aataacaacg tggcgaagta caacgagtag taatatgtca agggagtttg gaaccaggtg 109261 gccaaacacc aacttaatga aatcagccaa tcgccaaagt aattgatatg ctgtgattta 109321 gcccaccacc cgtcacataa taactttgta ccacgctttg tctgaatact ttttagattt 109381 tctaatttac cttgtctaaa ctcagatttt tgcttatttg ccgagtggaa gatgtggaaa 109441 cccaaaaaca ttatggctaa tataccgaca actttcaccc atcccaattc cacaggggaa 109501 acactcaagt aacgcgcttg taatgagtag gtgaatggaa ctaaacttaa gtcaccaaac 109561 gctagcatga aaccaaaccc atctgtagtg atatccatca tggttaatac accttcctcg 109621 tttagtactc catcgaaaat gtaaaatcct tgcaagaaat taaccaagac caatgcatcg 109681 ttgattttac cagtcttcag gtaatggtga tgcagacagg aaagattgat cagtaaccat 109741 aacaacatgc cgggtctcaa ctctgaaaac atcttgatat ctaatgggcc gagacgaggg 109801 ttcagttctc taccaataaa ccaatcgtaa atgatgtttc ctgaatttcc acctagtgct 109861 aagatctttt cccttttgcc attaccattt ttcttgaaga tcaatggtat gaagctggca 109921 acatagcagt acgtcgccaa aaagaacgaa aacaaaatag atattatgca taaactaacg 109981 tgattttcat acagatattg caattcaggc aattgtccat cagtcaattt ccatctgata 110041 gccaaaacta agaccaaagt tgtagacatg gcaattccat tgatcttata cgaaagcttc 110101 gaaccatccc ttaactgaac acccttcatg actctgcccg gtaaaatgac gtccaaaact 110161 gccagtattc cataccacag gcaatagaca gtccataatt cacgattgcc cagatagtag 110221 cgcaatggct tgataccgtt ccaaagctca actatatcga aattctggaa aaatccctta 110281 ataaaataat cgggccttat catttgattc aagatgatag tgaaaacagg cagccctatg 110341 ctgatgccta aggcaccaat cagcccacca aattcaaact ctgtagttct gggattcaaa 110401 gctgatacca tccttttatt ctctacaccg aatttgtctt tactcctatg ctgtttacaa 110461 ggtctatctg ataagcaatt gcgcaagaaa atagtagaat gaaaactgat tattaaaaac 110521 aaacgtaaac tcaagcctca cttgatgctc agacggagta cgtgaaaaac gtccgttatg 110581 caaaaccctt tatatgcaca accttcacac aatgcaaatt tccgatgatg cctacataca 110641 aaagagcgaa aggcgatata aatttttttc acgggatttt cgtttaggtg aaaataaaat 110701 gaacgacaga gcatgcagag tccgggtaat acatatgttt caatactgtt tcaatactgt 110761 ttcagaagtg cgtcacatat taattttaac ttataactgg cctgttgctg gcaagaggta 110821 tatatatatg acgaatgtga ccaacataag tccttaagat aatcccgaaa tatttggtta 110881 ggatgattcc ctttcgaatt tgtgaacgtt gatgatatga gcggttttaa atgctatttg 110941 caattgggtg acaggctctc tcaaatatgg ctaaataagt atactttggt tttgctgcta 111001 gcaatgctga agcttctgtt tttctccaaa tccatacaac atgcgataga agtctcggaa 111061 acgtatattt tgtccaattg ttacagtatt gattcactat actccaagat gacagacaac 111121 acgccgcact atttaggtat catggggaat tatcttatcg agaagggtat ggaggagact 111181 gttaaagcta cgctagagac gttatcactt atagtatatg cgagcgaggg gctggtaaac 111241 tttgccattg acctgtattt gggcacttat gcctgtttga ttgttagtgc cgttgatggt 111301 accgtggacg ttgctactaa cattacagaa aaactgatta gcttagtcaa tgatacagtt 111361 tcaagtgtgg ctaatgaatt ggatacgggc ttgaatgaca tctccaaaat aatcaataaa 111421 gtgatcaagg ccgcatccaa agtagagaat tttttcacag gtgatgacga tgacagtaac 111481 atgacgtcgt caatcaaaag cgtcaactta accatatctg cgcttcacaa tttatacatt 111541 ccttcctcaa tcaacgataa gcttgaagag ttatcggcaa agacgccgga ctttgcccag 111601 gttaagaata caaccaagaa cctgatctcg gttcccttca atgaagttcg gaagaatatc 111661 aaggccgtga atgccagcaa tataatcgga gatacctccg ttttgtacgt acctcccgtg 111721 tcccttgaca acagtactgg gatttgctca tccaatcaat cagaaatttt ggccttttat 111781 tccatcttgg gacatgtcct gaaaatagcc accgtagtgt gcattaccgt attgatatgc 111841 ttcgctgttg gtgcgatggc gcccgttgca tggaatgaaa tcaagctctg gaggcgcctt 111901 tgcggaatga gagaccatta catgctgagc aggcaagatt cgtatacgtc cttttccagt 111961 gaaaacacgc acgaattgaa agatccattt agagatcctc ctatacaaaa tggccaatat 112021 gatgtcattg caagctatca gcagtgcttt caaacatgga acacaagaat agcaggctgg 112081 atgacaaatc ttgttacctt tggaaaatca ccagagaaca ttgacccaaa gactaaacaa 112141 aaaatagaat gggtagtggc ttatatgacc tccgaaagag cactgtgtgt tcttggaatt 112201 ggacttttgg gaattttagt gtgcatatgc caatttgtca tgatagcact gttaaaacac 112261 aagataagcc attcattgac ttctaatgat ggtgacggcg ttcaaaattt gctgaagtct 112321 agcactgccg tcgatataga gaaccaaatg agcctttgga gcgttcagac taataaatat 112381 ataaatacta cggagaccaa tatcaatcag gaagtattcg ggtggataaa cacgacaaca 112441 ctttctgtga acaatacagt ggccaccatg atctctgata tagacacaac tttagcagat 112501 gtattcaatg gaacactgct atataaccca atgaaaaccg tggtcggatg tgccattgaa 112561 aataagctct acacaataga gaaggcaatg acgtggattc acgacaaggc tcagctgcat 112621 atcccgagaa ttaatgggac acaaatcaag caagctctgg caaagcaaac cgacaacagc 112681 actataccca ctgcaagctc cacttctgcc gccacagaaa acttactgga gaaccttgtg 112741 aatgatatga gagaaggact tttaaaaatt ctccgagctt accaccgtat aactctggga 112801 gaactcacgg tagccttggt cattcttgcg gtgtggctcg tacaattgcc catagctctg 112861 gtaattctcc gattacgtct tcgcaaagcc acctttgact gattaattag ttgatagact 112921 ttttccgtca taactctatt taataatgat gaccaaaaag aggctcgttc gaatcatttc 112981 gcgttgaatt tgaaattcgc ggaggaaaaa cacgcaaaga gaatcggaaa ccttatcgtc 113041 aaatcattgc accttgcaat ggtgggtaat gatacatcat cgcagtaaca gtattcatat 113101 attcgtatag ttaataagat cacttttcag ttagcttata caataaaaga tattaccttt 113161 tgtattgtta gttgcaacat ccttttttta taaactttga caggcgatat tacgtttgtc 113221 acttcggttt ccccacacaa agaacacgtt acttggcaaa ttcagctctt atgcgaattt 113281 tttcaggtga caacaaggta gttgattccc tcgcctctaa ccctggatta atgagtccat 113341 cgaattttgg cggtgacttc ggttcacgac taaaagtaaa tgtaacatca aaaaagaaac 113401 ttaacgactc atcaccaact tctcccatgg aaagttcacc agtttcacct gagttggtgc 113461 ctattctaac actgctaaat gcacatacac atagaagata tcatgaaggc gtgtttttga 113521 ttttacaaga ccttaacaac aatggcactc atgcagcaag gaaatggaag gacgtatatg 113581 gggtactgtt gggtactcaa ctagcccttt gggacgccaa ggaactagca gaattcactg 113641 atccgtcttg tccggtctct gaaaagaaac tgaaggaagt tgcttccaaa cccacttata 113701 tcaatttgac agatgctaca ctaagaactt tggataactc cgataatatc gtaatggagt 113761 gtggaaaaaa cctcactaat gcattggtgg tttctactac gctgaaaaac cgatatttct 113821 tacaattcgg taacaaagag tctttcaacg catggaattc tgctatacga ttatgtttat 113881 acgaatgttc ttcgttacaa gaggcttaca caggcgcatt tatttcaagt agaggcgcaa 113941 aattaggtga tatcagaatt ctccttacga atagaaaata tgattacaag gattgggtca 114001 gcgtcagatt cggagcaggt atgccgtgga agcgctgcta tgcggtaatc tctcaatcta 114061 gcagtaagaa aaagggtcat tttggtgaaa taaatcttta tgaaaatgac aagaaagtga 114121 agaaaaacca tgcaatggct actattgtag aggcaaaggc gctttatgct gtttacccgt 114181 cctcccctaa actaatagat tcctctacaa tcattaaagt cgtaggttct gtgaaatttg 114241 aaaaaaagga gtctgctcag gaaaaggatg tctttattat gcccgagaag catcaagctg 114301 taccaagtta tgacactata ataaggtttt taataccggc tatggatact tttaaactat 114361 atggaagacc agagaaatta ttgtcaagca agaacgaccc acattcactt ttgtttggtt 114421 tgccagtttt gccacatata tactacttgg aagtggagga tttacttcca ttgactaatt 114481 ctgtatcaag cttacactgg tcgaataacg aatggaagga acatatcagt gatattttac 114541 aaaggaaaat agcacaaggc tactgtgggt gtaattctac ttccaatatt acttctcctc 114601 taccttctcc tttccttggt tcagcagact tatttgaaag ggccgatggt gttttatcac 114661 cgaaactttc ttacgggtct aaatcttctt cgaataacag ctcgaagaac agtttgccaa 114721 agagagagcg tgtaaaattg tcatcttctt ctgaacagga ccttaataac tctgatagtc 114781 catctattaa acgtaaaagt cctccactag tgatatctga aagtccacac aaagtccaca 114841 cacctactga tgcatccttc agaacaagag tgacagaagg ttcaccttat gcgaagcaaa 114901 gacatcccaa gccgtttgcg tcatctgtaa acgattcacc atcagacaga gccaagtcga 114961 ggacagttcc ttacaataat aacgacagga aagcgaccac tcctgagaaa tttgaaagag 115021 gagaaacctc ttgtggtaag aacgtggacg aaagtttgga aaaggtccgg aatatgaagt 115081 tagaaattcc cgagtccaat tttgacaagt tcatgacaga caaaaatctg ttgtctgtgg 115141 attctaaatg ctctaatgag aagaagctct ctgtggaatc agatttgtct gcaatctacg 115201 aaaaatactc caatggtccc tttggtcaca ctgagggtct taacggatct tctgatgaaa 115261 cttaccttcg ttttcaacgg gcgtcagttc attcagagag caactacaat tcaagaaaat 115321 cctttacacc aagtgacttt tctaatggca atgaggaaga acatgccgtt ttacaagaat 115381 taaatagttt aacccaaaga attaatgaac taggcatgga aagtataaat tcaaactccg 115441 attcggacag aataaacggg tcatattcac aagtggattt tggtaacaat aacgacgagg 115501 acgatatgaa cctgttcgac ccagatttta tggcacaaga ccaattgcgt gctgaagaaa 115561 gagactacaa caaggatgat agaacaccct tagctaaggt ccctgcggcc tttcaatcaa 115621 ctggattggg cataaccccc gatgacgata tcgagagaca atacataacg gaacacagat 115681 cacgacatga agtgccaaag cggtctcccg agaaaccctc caacccgctg gaaataggta 115741 acccatacgc gaaacctggc acaaggttga ataccactca cacccacagc aaaactgatc 115801 gtagcattac ccctcagagg ggccagccag tcccatcagg ccagcagatt tcctcctacg 115861 tgcagccagc aaacattaat agtcctaaca aaatgtatgg tgcaaacaac tcggcaatgg 115921 gttcgcccag gaatccaaag acgagagcgc caccaggtcc atacaatcag ggatggaata 115981 accgcccctc gccttcaaat atttaccaac gtcctcatcc ctcagataca caaccacaag 116041 catatcatct ccccggaaac ccatactcaa cggggaacag gccaaacatg caagcgcaat 116101 atcacccgca gcaggtgccc atgcctatcc tgcagcagcc caatcgcccg taccaacctt 116161 atgcgatgaa tacgcacatg ggctctcctg gcggatatgc tggggcagca ccaccatttc 116221 agccagctaa cgtcaactac aatactaggc ctcagcagcc atggcctaca cctaactcac 116281 catccgcaca ctaccgtccg ccccctaacc tgaaccagcc tcaaaacggt agtgctggtt 116341 actatcgtcc gccggcacca caattgcaaa actcccaagc ccgtccacaa aagaaggacg 116401 gattctcaca gttcatgcca tctgcaacta cgaagaaccc atatgcccag taactcgacc 116461 gactggttgt aattttacaa aaagagagac aattaagaaa agaaacaagc gccaggcttc 116521 cgtatcccag tttttcatct cactttctgg gcacgattgt aataatactt catgataata 116581 actaaactat ataagtagtg tctcatccgt aaatatacat ttagacagat tcttgtattt 116641 tctccgggca atttttaact ttttttctgt tagggcacat gacacttgcc tattatggac 116701 agccagtaaa gatgtgccat atattgcccc ctttacgctc tctgccagta ttagtgggaa 116761 aaaaaaaact gaaaaaaaaa aaatcgcaga ctactaataa tcacgtgata tttcttttca 116821 ctctcttcat aaagttgcta aaaacacaca atcgaatgag cctctgagca gtataaattg 116881 tacttcaaag cactagtcat gaaaaacgct tacattagtt cagtttgtca aggttatgct 116941 attacttgta cttatttctt gctattgtta gtggctcccc acattgacgt attttcacgt 117001 gatgcgcctc actgcggaag gcgccacaca ttgcctgcaa aaaattgtgg atgcactcat 117061 ttgatagtaa actaagtcat gttaatcgtt tggatttggc acacacccac aaatatacac 117121 attacatata tatatatatt caaaatacag ctgcgtccaa tagatgagct tccgcttcgt 117181 tgtacaacct acctgctatc ttgttcacgg atatttcttg cttttaataa acaaaagtaa 117241 ctctagaaca gtcaagtctt cgataatttt tttagtcaca gggtccgtct aaagtttctc 117301 tttatttgga ataatagaaa agaaagaaaa aaacgtagta taaaaggaat gtcgcatact 117361 ttaaaatcga aaacgctcca agagctggac attgaggaga ttaaggaaac taacccattg 117421 ctcaaactag ttcaagggca gaggattgtt caagttccgg aactagtgct tgagtctggc 117481 gtggtcataa ataatttccc tattgcttat aagacgtggg gtacactgaa tgaagctggt 117541 gataatgttc tggtaatttg tcatgccttg actgggtccg cagatgttgc tgactggtgg 117601 ggccctcttc tgggtaacga cttagcattc gacccatcaa ggttttttat catatgttta 117661 aactctatgg gctctccata tgggtctttt tcgccattaa cgataaatga ggagacgggc 117721 gttagatatg gacccgaatt cccattatgt actgtgcgcg atgacgttag agctcacaga 117781 attgttctgg attctctggg agtaaagtca atagcctgtg ttattggtgg ctctatgggg 117841 gggatgctga gtttggaatg ggctgccatg tatggtaagg aatatgtgaa gaatatggtt 117901 gctctggcga catcagcaag acattctgcc tggtgcatat cgtggtctga ggctcaaaga 117961 caatcgattt actcagatcc caactacttg gacgggtact atccggtaga ggagcaacct 118021 gtggccggac tatcggctgc acgtatgtct gcattgttga cgtacaggac aagaaacagt 118081 ttcgagaaca aattctccag aagatctcct tcaatagcac aacaacaaaa agctcaaagg 118141 gaggagacac gcaaaccatc tactgtcagc gaacactccc tacaaatcca caatgatggg 118201 tataaaacaa aagccagcac tgccatcgct ggcatttctg ggcaaaaagg tcaaagcgtg 118261 gtgtccaccg catcttcttc ggattcattg aattcttcaa catcgatgac ttcggtaagt 118321 tctgtaacgg gtgaagtgaa ggacataaag cctgcgcaga cgtatttttc tgcacaaagt 118381 tacttgaggt accagggcac aaagttcatc aataggttcg acgccaattg ttacattgcc 118441 atcacacgta aactggatac gcacgatttg gcaagagaca gagtagatga catcactgag 118501 gtcctttcta ccatccaaca accatccctg atcatcggta tccaatctga tggactgttc 118561 acatattcag aacaagaatt tttggctgag cacataccga agtcgcaatt agaaaaaatt 118621 gaatctcccg aaggccacga tgccttccta ttggagttta agctgataaa caaactgata 118681 gtacaatttt taaaaaccaa ctgcaaggcc attaccgatg ccgctccaag agcttgggga 118741 ggtgacgttg gtaacgatga aacgaagacg tctgtctttg gtgaggccga agaagttacc 118801 aactggtagg gatagatacc acacatacct caggcataac atagataaac cagtacatgt 118861 atatctatat ctatatttat atatagacaa acagcattaa ttaactataa caaagtttct 118921 agtaacacta acggtagtag tagatttctc ttttttgtcc tcgttgttaa aaaacgaaag 118981 aagaatgaaa aaaaaaaaaa aaaacagaag agtaatagct agtgctttag agctttccac 119041 attttgaccg cacttgtaga cagccactct tgcgttgcca ctcgacatta catgaacaac 119101 tgttcttctc cctgtagcct tagcttactt caaacttttt tcgtttagcg gggaaaatac 119161 atcactgaag taatttttag atcactcgtg gcgtaaaagt aagcatatcg caataatcat 119221 actcatatcc tttatcatcc aaaaagtagt aatagcgctg gcaaggcatg tcgaatgaga 119281 gcacacgagt taccgttagt cgcggttgta cagcctccga cgagtgtgcg caagcattgg 119341 aacggacaaa cgatgagcta gacagagaat catcggtatc agaaagtaga agtgatgaag 119401 agagccacga gaagttatcc cgacgtcgat tcccgacgct aggtataggc atatggctcg 119461 atttgaagga cagaataccg tattacaagt cagattgggt agatgcgttt aattacagag 119521 ttattccctc tattgttgac acctacttta ataacctgct acctgcaata gcctttgcgc 119581 aagatatgtt tgataggact gataattcct atggtgtgaa cgaagtactt ctatccagtg 119641 caatggctgg aattgttttt ggagttcttg gtggacagcc cttatgtata gtgggtgtta 119701 ctggccccat ctctattttt aattatacgg tctacgaaat tataaagcct ttgaatacca 119761 gctattttgg cttcatgttt tggatttgta tgtggtctat gatttttcat ttagttttag 119821 catttacgaa cgccgtttgc ctcttgcaat acgtgactac gttcccatgt gacatatttg 119881 gattatttat taatgtggtc tacattcaaa aaggaataca aattttaaca agacagttca 119941 gtgctaaatc aggggagaaa tcagtacaag acggatttgc tagtgtcgtg gtggcgctgg 120001 ttatgactgc gtttggtctt ttctttaaat tatttcatta ttaccccctc ttttctcata 120061 ggatcagaac attcatatct gattattcaa ctgcgctttc agtgctattc tggtcatcat 120121 ttacacattt tggtggctac ttgcatgatg tcaaatttaa aaaattgcct attacgaaag 120181 ctttttttcc tacttccaaa gtcaataggc ctcaaaatac ttggctggca tatgaaccga 120241 ttcctgttaa agacgtcttt attgccctac catttggtat atttttaaca atcttgtttt 120301 actttgatca taacgtatcg tcgctaatgg cacaaaggca tcagtataag ctgaaaaaac 120361 catcctcttt tcattacgat ttcgcactat tgggacttac cacttgcatc agcggggttc 120421 taggaatccc ggcgcccaat ggtttgattc ctcaagcacc attgcacaca gagacactgc 120481 tagttaggga ttcaaaccaa aaggttatca gttgcgtaga gcaaagattt acaaatacgt 120541 ttcagggcct gatgattcta gggacaatga caagaccgtt attggtatgc ttaggagaaa 120601 tccctcaggc agtactttcc ggattgtttt tcattatggg catcaatggc ctaatgacaa 120661 atagtattat acaacggttg gttttcctgt tttcagaccc taacagaaga gataatactt 120721 cacctttaat gaaagtatcc aagaagtcaa tgctgatatt tctttccttt agcctgacgg 120781 ggtttgctgg tgaatttgct atcacaaata ctatagcggc catcggcttt cccttagtat 120841 tgcttttaag tgtgttagtt tctttctcgt ttgcttatat tttcccgact gaagaattaa 120901 agattctcga tactaatgtg gcacaaaaat ttaccattaa aaatttgtta ttggaaaata 120961 ttcgtgatgc aaagttctgt gataagcatg aagactaaac gcagttagga tgtacaaaag 121021 tcaaccactt gtaatatata gaaattaatt gcatatataa gaagtataat aatattatcg 121081 catttcgaaa ggaagaataa aactatggat cttgtagtca aactaatggc ttagattcat 121141 tgggccagtc ttcattttgt aattccggaa caatagtcaa gactttcccg gtcaatatca 121201 cattctttgc attttcaacg accagttctt ccattttctt tcttgtttct acactatgtg 121261 tgcccatatg aggcagtcct aagacttggg acatcgataa taactctttg gatatttttg 121321 gctcatattc gaaaacgtcc aaaccagcac ttctaatctt tccagaacgc aaagcatcag 121381 tcatggcttg ttcgtctatc acggcaccac gcgctgtgtt aacaataact acaccatctt 121441 tcattttttc aatagtctct gcattgatta gatggtgagt attgtggttc agtgggacgt 121501 ttacagatac tatatcagaa cgcttcaaaa actcctcgaa tcctacatat tcacaaccat 121561 gctcttcttc ggaaggaagc tggtgtctgt tatgatatat gaaattctcg aacccaaacg 121621 gcttcaatct ctctaaaata caacgaccaa tcctacctag acccagtata ccaactgttt 121681 tcccttcagg gtcgtatcca aagggagaac cacatgcggg tcctgcctcc ggccagtttc 121741 cctcgatcaa ccttctgtta ccaataccga agtttcttag ggcacccaat agcaaaaata 121801 catgcgtatc agcggtagca ttgctaacta aatcaggaac attggcaacc tggatgtgcc 121861 ttttcttgaa tggctcaaca tcaatttggt cataaccagc accagtatga catacagcca 121921 ctacggagga gggcaaagca agagcaagct cttcatcaaa tctaccggtg tttttcacac 121981 tccttgctgt tctagtaatg acttgtactt gggagagctt attttgtggg tcttttacct 122041 cccgcaaaaa ctgttctcta gtggtggatt cagggatggt aattacatcc gcaatctttt 122101 ccaattcccc ccaggcttgg tcaccaaagg catcctttcc taatttcaaa acaattggtt 122161 tcttactcat attctcttct cctcttcttg ctcgtttatg tattgttaat acttcggtat 122221 tgtagagcaa taatcatgta gaaggatttc cctaacgtaa caacaaggcc aatagaattt 122281 actttttata tgctcgagat tagtgaaaaa tgggataaga ttgccttgtt atccccgccc 122341 cctgccaaga cttttgcaga ttttaagtcc gctctcggtc ctacgtaata aatgcctgga 122401 gaagctctag agctaattgc gtcgtccttc aggaattctg aagaccacag caacgcaatc 122461 agatggcgga accacattat gaagccaagt gaggtgtata cagagttata cgtacttttc 122521 atccatcccc gctcggtttc accgttcata acgctggttt tcactgccac ttctcatatc 122581 aagtcagcga aataaccagt agttgtcctg tatataggca tccctaccgt ttgctttagg 122641 aagctgttct gtgttactat cacaactggg tagtgccctg tatgaattgc ttccctgtgg 122701 aaatggccct tccattatgc tactttgacg cgtttactgc cgcattacgc gtttacgatg 122761 aaaaattaaa atgagtatta aggatttttc aaatgagata tggttcgtaa gtcgcctcac 122821 atatgataat accatctagc ttgtggggtt tagtgtatct ttaatatagg agggcgcaca 122881 ctatgtctgc tgatttgcaa caaggcacta caaatgcggc tgatttctct ctgacggtac 122941 ttagagcaag aattgcttta ttggcaactg ccatcggtgg gccggattat acttcccaga 123001 tagacccacc cccttataag cttggcgatg actgtttggc gtgcttaaaa gatctgaaaa 123061 gatggtttaa actagtggat gaccagcaga aaagatggga tgtggcaatg gcagtagctg 123121 aatatcgcat cttgacggat gatctgttac ctattctgat agattgggaa aacaaatgtt 123181 ctcttgcagc aaagcttgca aagaacaacc cagaccatga agagtttaga aacaaagctt 123241 attacgataa aattgcgcta aattgtctac aactattggt ccttatgact tggcctttaa 123301 ttgtaactga acagtcttca tcaaatcaaa ttactctcta tggtgagcta aagaagcatc 123361 aattggtata caagaaaacg attctgtcta tggaaagtgg taaagtgtta agagctgcca 123421 ttagattggc tctggatgtt atcaaaatcg accgattatc aagaactcct agggacaata 123481 tggttctcaa attggttttg aattttttca gaaatgtcat tgctatagaa cccggtgaat 123541 ttactatcaa tactaagaaa agcatgccta agaaaggtat cacatctatc gatactttgc 123601 caccaaacgt ctctatggat gacatctctt taaatacggt tatttcctca ttccataaaa 123661 acaaggtatt cggtttcctc ttaacgctga ccagctcctt atcaaaagag tttgaccagg 123721 actttatcaa tatcccactg ttggagatta tgttctactt cactaaagat gttaaccaag 123781 aactgctatt ccctcgacag ttcgaaaccg ggacacattc aaaggtggta aataaaaatg 123841 agagctcctc tgctaataac attgttacaa gtgcaggttt tgaactatcg aagttattac 123901 aaaaggaaca ccaaatgaga aaaaacgtta tcaagcatac atctgcaaga cactccagat 123961 ttggtggtct tttatctata caaacaccag ataaaactag gttaactgtt tctggtagcc 124021 aagctctcgt agatgaaaaa atagcgctcc aaaaactaga tgacagcaaa aaatggaata 124081 aaagaataat taaaaagcat caatctgtcg cagctgaggg cttaccgaat agtctcttga 124141 attcacaaac cggtaaagct atttttttca ccgaatcaaa tggtaaacat ttcaaagaat 124201 tcatcaacaa ctttatagat tccggcttta acatcttgtt gcatagtgtg acgaactact 124261 tcacaactga gcaggatagg atggtaactt tggagcaagt cgaatattta cttttctttg 124321 catggtttgt taaataccag ttgttgaggt ccaaaatcga caattccgca gatataaagc 124381 aagtttcaga agccttgaaa gaggtgactt tcattctagt gtcttctctt ttaagaagcg 124441 catatgacct gaaaaattgg acagtgacac atgctggtat gattgcattt aatgaactgt 124501 tgaacctcgt ttcccgtaca aaggccgctc aagaagagga ttcgaccgat atagaattca 124561 ttgtaagtag gcttttcagt gacgagagaa tacaattact gtcaaatctg ccgaagattg 124621 gttccaaata ctccctccaa ttcatgaaaa gttgcattga actaacacac tcggtattga 124681 aagtattaga gcaatactct gacgataaaa cattagttat tgaaggcaaa tcaagacggc 124741 aaaaaaagtt taatatttca gaaggtgata ttactaaatt gatagaagaa gaaaatgtag 124801 atagagatga agcgcttgat attctaacct cttctttaag aagtatagaa gtcaattttc 124861 aaaaggtgca agccaactat atgacagaac cggtaataga aacgtacatt aatttccttg 124921 aaagatttcg tgagcttgag gacgattcca ttaaaaaagt attttccttt ttccatagag 124981 tatttgttca ggcaaaagaa caggcattgt tatttagatt tgatttgata atattattaa 125041 gagaaatgct ttcacctgac ggattagata gaatgtctcg ttcaaggaaa tatgtgagtc 125101 aattttcaga ctacttcctc gccaggttga agaaaaggtt aaagaaatca cctgcttggt 125161 ttgttggatt acttttcccg ccattacaca atagtgaagt aggattttac caaagatatg 125221 gtgaatataa tgtacttaat aatgaatcaa tgtatgccgc tcctgcatca cagttcaaac 125281 caattcccga tgaagaagcc ttaccacctt cgattttgtt ggatatgaaa tatggtgttt 125341 tagtttccac attacttgat gatggaaaaa ctgaactatt ggaccaactg ctcaagcata 125401 taacccacac actagatatt tttaagtcgt ggctaaccgt aaatgttaat gctgggaaag 125461 aaacagttaa tccacccaat gaatatttca cattgacagg tgtactcaac aacgacccta 125521 tttttaaaga taaggactac agggctttat tgttgctgat aggatactcc attccacgta 125581 aaatcaatga accttgtttt ttaccgggga ctgttgaagt ttctgacctg actgtttctt 125641 gtgaactagt gaaaaaatac ttatcaacac catttgaaac tccaaacgga ctgccttctt 125701 cttcctatct tctacgagtt cgttcagaaa aggatagttt ttctcacaat gaacaagatg 125761 gatgggaagg agacgatgat tatgattaca acgatcccta cattgttcca gatgatcaaa 125821 ttttatcgaa aagcgacgca gcatacttca aggatttaga taacaatgca tcagataaac 125881 ttaaaggtac caaattcagt aaagggattg cgagatccaa aaaaaaagat aagaggaagc 125941 gtaggaaagg agaagccaag actaatttgc caatgtttgg cgaccaggat gatgaacgac 126001 ctcagaccgt tagagaacgc catggcgtat tcagtaaaga gtttattagt gattcagaag 126061 atgacgagga tttgatgaac cctatatttt ttgaaaacga aacatatatg agatggttac 126121 tagataaaaa caatggtcag ttgaccgagg atagatatat ccagtttgcc aaatttgccg 126181 cggaaaggat gaataatggg ggtgttgtga caggagatta tacgagcttg tttggtggat 126241 ccataccaag tattgaaagc ataagagcta cagaaagtag ttcctttgcg ccagataaaa 126301 gcctcatttc tttagcaagc cacgtggcat ctgaaatgtc tattttcgat gtaaataata 126361 acaataataa tcaactctct gatgacgatg tcaactcgga atcaagaaat agtttgggct 126421 catcacagcc atcaaattcg caaaatatgt tccaatctga ggtgtatagc agaaaagaat 126481 ctacaaagcg ttctttggaa gcgagtgcag ccgatgaaag cgatgaagat gaagaggcca 126541 tccgcctttt tggcaaaaag tctagagttg ttttgagcca aggtgatagt gatgattgag 126601 aatgaatatg tagtaattaa tccctttaat acgtgtaatt ttagaaccac ttctttactc 126661 tgtttttaag ttcaaagtat tgacataata ttaaaacaat acatgcgatt cattctttat 126721 cattacctat atttttctaa gttgttgaac atcttaagga actcaaatgt ccattaggac 126781 acataaaatt aaatattata taatttattg ctgttcctgg gcatcatcga aattgtcatc 126841 attgcttgaa gacgcatgca atccgctact aggactattt tcccctattt gttcttgggt 126901 tttgtcgcct atcgtcaagt ttgtctttaa agttttttca ttattatcct tcttagagtt 126961 ctcgtctcca gaagatgccc tcttcgagga tatattttgt tttacattag actcagcgtt 127021 ttcaaattca gtctgatcaa ttgcgctttc ttctctaaat tgctcttcta aatcatccaa 127081 atcttggagt aacttcttct tttgtatctt gcgttgagga gcctttttct ttattataga 127141 acgacctttt ttatctccgc aatcgctgtt ttcttcatta ttatttgccg acttaatgct 127201 acttttgtca tctttcgtta ccgtgtcatc accttcaccg ttgtctatac tctctggtga 127261 actagaatct gcgctacttg tagtagaatc tgctagagaa gattcatctt ctgatgaact 127321 atctgcggtt gaattatctg tggaagaccc atctgaagag gattcatcac ttgaagattc 127381 acccgtaatt tcattttcca tatctccact ttcaaagtca aaagcgtcgc tcttttgact 127441 ttcttctgcg ctagatgaag aaaaaggtct ttttgcgtcc tgcttccaaa gagctttgtc 127501 ctgcaagcga accgatatag catcgttttg atcctcatcg ctgtcatcct caactaacgg 127561 tccaattttt gaagaaattg aatcatccac tgcccatatg ccaatatgag tccaatgaag 127621 tatacaacgc aatttacaca attgcagcca tgctctttga atattagtgg taggttgtcc 127681 tggctttgca tttgtttcag aagaaaaaat ctccatcttt ggcttatttt ttgttgaaga 127741 attgatacca agtcctgcca taaaacttaa acgtttggtt tttttgtctt gagaagaaac 127801 cctgccgtct cttttggtat gcttcgttac ttcagagaat ttttccaaat cttccttggt 127861 aatgttctgc gtcgttagct tttctaaatg ccatgcgcct accttcaatg atctcaggaa 127921 agcaaagatt tcacatgtct gccgcaactt tagcaaacac caatgacaca agggatacgt 127981 attcgtaact tgttctttac cgtcgtcagt cttgtgcaac gttttcaata tatacatcct 128041 tgcgtgttcg ataatgtcat ctctagattc tccacaaaag gaacatgcgg cgtgcactgc 128101 aactggaggt gaatctaagg gaaacttgaa catttttggc atattcgaag tggcttgctt 128161 tgcagggcta cttgagttgt agccaatttg gtaggttgca ttaacgccgc ttaggggttc 128221 cacgaccacc aaaccatcta taatcaagga aagtagggtt tttttaacca accagccgat 128281 gcctgaagca ttatcaatct taagtatagg ctggatttca tcatttacca atcttcgtat 128341 taactttgat tcggttgaag ttgcctttat gttttcacaa cggggtagtg cagcgacaaa 128401 ttttagaaat tcattgtaaa ggcttatatc ataacgaata gatgaaatgc ttggcgagta 128461 cacaattccg ctataaatat cttgggaagc aagagaatat gaagttggaa ctttattcaa 128521 agaagtgcta gaagaagttg ctgaatcact caatattgtg gaatatctgt tcgaattatt 128581 tgtgactgtg ctttcattat ctaaactatg catcactttt ttcagattct tgagctgtag 128641 ggtcaaagta tccagtaatg tgtccttttc acgcagttgt tcagtgagtc tcttatttaa 128701 gatttcgata gcatatttct cctttctagc atcagcaacc atattattag cctcatcaaa 128761 gagggaagca gtcagatcct caacttcttt atttagttta tccgcttcct cttcagcttt 128821 agttcgaagc tcattttctt tggctatatc ttcacgcaat cttttcactt cgtcatctct 128881 gtctgacaat tctcttttta aagtgttgta atcttctttc aactgattat agttttcaat 128941 tgctgccttc tggctggcta ttgtttttaa ggatttatta agctgttctt ctaagtgtga 129001 ctgtttatcc acgctctcga tcaattgcgt agacagggat gtaacctgta ttgatactct 129061 ttttgcttcc tcagaagcat ccatattgaa acctttatca aacacagcta gtaaaggaaa 129121 atatatccca gtgaactaaa ggtcaaaatt ttctacaact tttggatgga aatcaacgtt 129181 gctacagctg caagtgacaa atgatattat tgcacgaatc actgtgcttg tcacttaggt 129241 aaacgagagc catgttttaa aggtgcttca gcgaacgcga aatacaagtt ccgggtagtc 129301 acatggaaac aatggcacat aataaaagga attatttcaa aaatgcaata gtagagatca 129361 tttgagtaaa gatgaatgta aagtgtatca taagtgatct ataaacatta aaattatata 129421 tatatatgtg atttaatgat tcgtgactat ttctttgtac tagtgcttgt ttggatgttt 129481 gttttggtat tactgttgtc ataatttttt ggtttaatat tttatttgaa acttagcctg 129541 ttacctgtgc tagcctcacc tatggatctt tccttgcggg ccctcaattt ttctagatgt 129601 tcatcgagta tggaattttg ctttactggt gtgtcagagc ctcttagctc ctttaataac 129661 attctagctc tgtcactaat ttcctcttga tcttccagcg cagatgtctt ggatggcgat 129721 ggtaaatctt cagaggtatt cataacaccc cttgtggcaa gcggagtggg tgattcagcg 129781 tgaatcactg tatcggcagt agggtccata gcttctggag aataaagaat agacccttct 129841 tcagtatcca aatcgttgag taattgtgga gcgttgtctt tttcagaaag atattttttc 129901 ctcactaggg ctctctttct ggcggaagat gggtcacttt tagcaggacc tgcatttttc 129961 aactgttcta atagtttatc cataacagcg cgcctatctt ctgcttcatc ctcttcattt 130021 ccttcagatg aaggcgaatt gctgttctct ttttgttttt ccttttcttg tgcccttttt 130081 tgctgttctt ccactatttt cttatgcttt atataaagtc tttcttcttc ttccgcggct 130141 agattttgcg cttgagcttt tttgtattca tttataaaat ctgcaaattt cttaaagaat 130201 gagatttttg caaacttatc accagaatct tcaccgtacg tatgcatcag actttcaaat 130261 tccatgatag tcagcttaac ttcgtcttct aacaagtccc ccttttttct ggcttccggt 130321 aacacgggca atgtttttat caaaacttta tctaatggat gaaactttga ggaatcgctt 130381 aaattaccaa tttcaactga acgctctacg tttacaatcg attggctaaa gtccttacag 130441 tcgttaacta actgctcaat ggaaactttc acgacatcca atacaggttc taattcactt 130501 agaaagtcat tgaagcttgg ataatttaac ctgacaattt tttcgacgta atttagaaag 130561 gtcatgctat tggtagtatc cttgataaac gtcaacctct gcaaggttga aagtttgaaa 130621 ccttgtgcct gcttagaagt gtcgttcatg aaattaccaa ctgctaagat aacattaaag 130681 acattgcgca agttatctga ttcttgaagc gcgctaacag ctttgtcgac ttttcttaac 130741 tttgccaata actcattata ttctctttca tacgaagtaa ccactgtgag agctctcata 130801 cgtgaacccc agtatgattc tagattaacc atcaattgca aataaatttg gtcagccctc 130861 tgtaaatcgt ttggatcttt ttcagggggc ttggcatctt cgagattcct cacgccctcc 130921 cagtctgtcg aatacggggc gtaattccta gctaaattaa cagaaacttc aattatttca 130981 gattttgaca aaaactcaac aacactcggt gtttgcaaaa aatccctatc gcagtttaga 131041 atctttttca ccagatcggc aaccgaaagt gatgaataca tatgcaaatt gataccaaac 131101 tgttgagaaa tatccctgga taaaaatgta attttctgca gatcttcctt gcgcttgctt 131161 gctaatgatt taatttccct agcggcaaag gccttttcta aatcagcaag aacacccttt 131221 tcgtataagt catctgcgaa cttctcagct ttacctgtac cccaaataga attatcagta 131281 caatctaatt tttcccaatg cagttgcttt aatttcttgt gtggacgagg atacttttca 131341 aataatgagg gcgattgagg aagtaatggt gatgttacag ctgatttgat ttgcgatgcc 131401 ggcatcatag gtggagctgg cggaatgacg ccatcagtag atgaagataa tacagatggt 131461 agcggcggcg gtggtggtgt ttctcccttg ggtttgccga acaatgccat gggtggagga 131521 ggaggtggtg gtggtggagg gggaggagca ggagaatccc cagtagtttc ttgcttgaca 131581 gtgtcgtctt ccgacttttt ctctttctcc aacgattcac cgaacaattt ggcgggaact 131641 ggaggaggag gaggaggagg cggtggcggc tgtgaggaga gtacagatga ttgagtagag 131701 agatcttctg cgccatctgt attattcagt ttactcacag cgctgaaatc cgctgtttta 131761 tcttcttcat gatttaccac acgcccttgc tttccgtttt ccacatgttg tctcatgtct 131821 ttctcagctt tgtcaaaggc ggaagctgca cttgccgtgc tgttttccgg taaagatttt 131881 ttatctagac cttcatcttc attttgttca tatggttcaa ctttatttac cttctgtgtt 131941 aactcctcta aatatggagc agaagacacg gtggattttc tgagtctgtt cataaaggtc 132001 ttttcaactt tactatgtag aggtccaata cccgaaccgt tattgttctc tccaaaagca 132061 gccgatgcag taacattttg accagtacca tatttttgag ataaggcatc gagaaaagac 132121 ccaggacctg atcctgaaga tagctctgag tgttcgctcc ttagttcttg agttggagat 132181 gcgtcttggt atatttcctc actttcatca tcagaacttg aagaggaaag atcgctttcc 132241 ccatcttctt ctacttgtat ttcgtgttcg gtttgagtct gaatatctaa caactggtcc 132301 gttattctat taatctcgtc taactttttc tgatatgtct tagggtcaag actggcatag 132361 ttagcgtctt cttccgtttc cacgtcccca gtatttttct ttggactgtc cataatctcg 132421 tcgacattaa agtcaatacc aaatcctttg tattttgttt ctagttcttt cagtctcttt 132481 aaagccagag atttcttttc attaaatagc tcattaacac gttcttcgac gttaaatttg 132541 gaaatatcat tactttccat ttggatttca gccaaagccc gccttaggtc atttagttta 132601 tttacgtccg cctcttgagg cttgactaaa ggtttcctat ccttattttt catcttcttc 132661 actttgggct tcttaatatg tattggaggt tcaagacgat ctttctcaaa ttcagcaaaa 132721 tttgtcatct ctagttgcct ggcttcattt tcaatatttt ccatttgcat tcttaacatt 132781 tttaatctct tattaggttg aagtgtcatg ccgaattttt ttgaatcatc cttgtaatcc 132841 ttttttgctc ttgataatcc gtcctgtaac accttttgga tattcgcttt ctctgaagaa 132901 tttaggctcg agttcatacc tctggtgcct tcattcttat tgaagctttc ttcaggcctc 132961 gaattcaata tagtcaacat ttttctcaat tctacctctt gctgatgctt ttccaaaaga 133021 tgcttctttt tcaactcttc taactcagct tccagctgct gcataactct ctgattctta 133081 gctaaaatac gatctctctc atgcaactca tcttctaact gtccaacgag tccgtgctcc 133141 gccttgctta acttttcact taaagaatcc ctttctgcct gaatttcttc caatttcttc 133201 gttagagctc tactttctaa tatagctcga cgtgcaactt catcagtctg catggcatcg 133261 taaagccgct ggatagccat attcatatta gtttcttcat cagaagttga ggcaacacta 133321 acattagtca ccaaagaatc cataagtttc aattgcttag taagtttaga ggaattttgg 133381 ttttcttcta ttaactttga actagaaagg aaaagatgtt gaactaaaga tactaaaagc 133441 ttttcattct cggtaccttt acatatatcc caaaggtttt ttaataatga tagtggatcg 133501 tgtaaatcta cattaaaagc cttattgttg gcctctaatt taacgttaaa atcgtcaagt 133561 ttattattgt catataactc aatttggtca attaccttgt cgtaatctag cagttttatt 133621 ttgttcataa ttcgtaaaat tccacaattt tctagtttcg tccttaatag cattctttga 133681 tttatgttat cagagcaaga gcataaatga ttgataaaaa ccattgtcca ttggcagtat 133741 tctagaatcg cattttcacc cccaccattt ttaaattcat ccgacgcgcc tactaaggaa 133801 cccatttttc ctcttccatc taaagtttgt tcaacggcaa ataaccaggc ttgaataatt 133861 ttcaaatgac tttccaaggt taaatgagag aaatactggg gcattttttt gaagttttga 133921 atcatatgaa gattttgccc tatcctaaac tttttatcta gtgaggtaag aactgcttcg 133981 aatctgcttt tatttttttt ttctagcata caaacaaaaa tttcagtggc cattttcctt 134041 gtggccagtt tcgtagagaa taaaccttct gcaacagtat cagtcattaa cctatgtgta 134101 ctgaactcat acaaaccttg tgagagcatt gataagactc tgaagcattt aaaaaatgaa 134161 ttttctttct ctaataattc tttagtcaag ttttctcggg gtgcagtctt ataaatagag 134221 ttcattagta cattagccat agcaatgtga ccctgatggt ctataaaagc gtctacccag 134281 tctaactgtt cagttcttaa agttacccat aaatctttca tctcatcgct agtaagtttg 134341 tctgccagga ttcgttgcac ataatgtatc ggtggtctgt ttgttctgtc tcctggaaga 134401 gtagatgcac tcgtattgtt ctcagcccca cctctataaa tattgtttag agatggctgc 134461 tttttcaaac tcccgctcac taattttttc cccttcgagg ttgacgtacc taccgatgaa 134521 agagtagtag aatgatttaa actgttgctg tatacagttg aggtgggaga agaggcgctt 134581 gtcatcaaaa cagatttggg agacgaaaga gatgaattag ccgtaaggat aggatgatgg 134641 tccgacgcca tcgaagttct ggaggcagtg gaagaagatg tagtgtttgc tcgcattttt 134701 tttagctcat tttgtaaatc ctgcttaaca atcagccatt tcttctcaat gctgtagccc 134761 atcagagctt cttgtttgtc ctctgataaa gactgaaaaa tatttctttt atacataata 134821 tcttcaaaca aaacttccac ctcgtatggg tccgacggca tttctaaata aattttacca 134881 tcgggtgtag tgaatttgct caagttagtt agcgaacctt gagagagaag acttgatgcg 134941 gagtgacttt gcccggtatg ctgccttgtt agcttattgg acgcctgtga agaattcctc 135001 ttggaatacg aatatttcga ttgcattgaa tgcgaccttg cgtgctgtga ggatacggga 135061 acatctccac ttaatttacc attcatatat tgagacaagt tttgtgtgtt taatgtcgat 135121 tttttattca acggcctcgc ctcagtagat gtagacctag aaggtgcatt cagttttcta 135181 aaagatgacg aagatgcagg tgaagtggac acttcgtttc ccactggaga gtgctgttgt 135241 tgggatgcat aggtcggaga acccgtattg ctattcgttg catttgagtt agccaaacgc 135301 ttcaaatttt ggaatatacc agaactcgaa ttcgaatgac tttcctttga gttcgaatgt 135361 ttggagcctg aattcttcaa catttccttt ccttctcttc ctttcttgct tctcgtttgt 135421 tgaaaaggtt caggtgcctt ctttatgtgg cgtgtattta gaatttaact aggcttgagt 135481 taaaatgttt ctcctcaata cagaagatag atacaaatgg caaaaaaaaa agtaaaaaat 135541 ggcccaactg tatgagacgt ataaaaaacg tgaagggtga agaaaagaat gccactgtcc 135601 aattttatgc ttaatacgaa aataattaac acacagccgt cagtgtcctc ttatctgtag 135661 gaagggtccg tgctattgtt cttaaaaggg attctagttt tccacatctg ttttttcttt 135721 ctttccctct tccacgtcaa aaacttcctc taaccgatgt cgggtaagcc atggaaatta 135781 cgggcgatga ctttcggcgg ctaacaacga aacaactagg gagtaatcat ataatcacag 135841 gaaaagagtt gagcaaggat ttggcaaata tacatataca tacatacata catacataca 135901 tatatatgtg tgtgtgtggt atggagtatt attctaaaat tatgaaagga catcccaaac 135961 tcgttgccac cttgttttac attctggctc tatccatacc aactcctcta tttgccggcg 136021 gtcagaatcg atatcgatat cctgcagctt ccagagtaag cggcacttaa accaaacttg 136081 gaatgataac catatggcca aaaataggaa tattgatata tatgcagcga caaagtctat 136141 aggctgaaaa gtaggtgcga aagcggtgaa gccctggatc agaacaatta gagcgatgaa 136201 aaaagatgca taatatgcca aaaaaggcat catttgagct ttataaggta agtcatccct 136261 cgatatacca cgtttcctta tggcttgcat gaaacggata tgagaaaatg aaatcaaaag 136321 ccaggcaaag aaaccggcca caccagttat gttcaataac cagttaaagg ccttgccgct 136381 gcctgcagaa acctctaaga aagccaaaaa tccgaacacg gatgtagata gaacagaaaa 136441 gtatggaaca ccacctctgg tcacgttaga caagaacctt ggcgccaagc tatttttaga 136501 cagactatac agtactcttg agccaatgta cacattagag ttacctgcgg aaagaatggt 136561 gattagcacg accgcgttaa atatatctgg gagaactttt gtgcctgaat tctcaatgct 136621 tatcataaag ggcgatgaag agacaaatat accgtcacta tccaactttg ggtcattata 136681 tgggaccaaa aggccaatga aaaatagtga aagaatgtaa aagactagaa tcctcactac 136741 aactttcttt attgccctcg ggagagcttt tcttgggtta gccgcttcac cagcggttat 136801 cccaaccagt tcagtacctt ggtacgtaaa tgcagcatta atcaaagagg aaacccatcc 136861 gagaaaacgg ccctcatttt tatcactgga gataatgcca ggcccccagg ctcctggatt 136921 tctccagtac ctgaaaccga tgggtccatc agattgtccc gcaccacaca caacacagaa 136981 tgagaaaatg ataaaaccga gcaacgcgat gacctttatg gaggcaatac aaaactcaaa 137041 ttctccgtaa tactttacgg gaaacatgtt cattgaagtt aacaggcacc aaaagatcac 137101 gatccaagcc gctagaggca ctgcttctgt ccagtactga ataactttcc ccaaaacgga 137161 tagttccagt gcgaaggtga aacaccacga cagccagtac atatatccgt tagtcgctcc 137221 cagcgctggc gacagaaatc tttgggcgaa gacagaaaat gaagatgtaa ccgggataaa 137281 agtgaccatc tctcctaacg attgtgtaac ggagtaaatc actgtcccca taaataaata 137341 cgatatcaag gcaccaacag ggccggcgtg tgccaatggc ggaccaatac caattatgag 137401 gcccgtccca atggtgccgc cgagagcaat catccctata tgccgctgct ttaacttccg 137461 cttcacctct cttctttctt gtggtgagct ctctgtttcc ttagcagcat catcctcgac 137521 ttttctctct gtggtgatgg ccttcgtaac gttctcccca gaatattgtt catctacaaa 137581 ctcctcctct tttattatag agctagaatt gatttcatac tgaccttcct tggacatttg 137641 tatgttcaca gtttcatcca tggcaataat cgcaacacta caattttgcc gctaatatat 137701 gtctattgtg ctacggaaga gtaacaaaaa aaacaaaaac tgcataacaa gcaagtttta 137761 tacaatacac attataaaaa tttctactcc ggtgttccga gctcccattg ccattggaga 137821 aagcccttat gtggagtgga gctgcctaca ggttgttttc aggaaagaca tggttacaaa 137881 aaagacgaca ttcgcccaac ttatcactcg cttgaaccac tttttatgcc aagcccttaa 137941 acgccgcgac tcaaaaacat acatactgtg ccgcacggca gtttttggcg ctatgacacc 138001 cttttcccca agaaaatcgc atattaacaa caaattaccc atgcaaccca ggaaaaaaaa 138061 aatagtcatt atatacgtag tgcgctttca ttgacaacta catttttgtg caacttttgg 138121 tacaccgcta cacgtattga aagcgcaaaa gactatagct cctccagcag ggaaaactca 138181 catcggtggg caacaacata gaatatgtca aagttgtaaa aacacccacg agtgcatacc 138241 acttttcaac attaccgggg aaaaaaaagt ttgcacctcg ttcccagaaa catacgcagg 138301 agtgactgcg ctagtgacag attgctcttt ccgttggaaa aagaaacgac tttttttcgc 138361 aaaagtaccc gaaatcctcg gaattttgca aatagtcgat gatcacaatt gttaggtgac 138421 tatttaacaa ggacggcgag gagaactgaa aaaaaagcaa cctatccggc ctcctctagt 138481 tacacaaaca agacaaagaa attgcattgt ctataacgat aacaaaagac atcgtatata 138541 tatatatata tgggcaggtt tagtaacata ataacgtcca ataaatggga cgagaaacaa 138601 aacaacattg gcgaacagag catgcaggaa ttaccagaag accagataga acatgagatg 138661 gaagcaatag atccaagtaa taagacgacc ccatactcta ttgatgagaa acagtacaac 138721 acaaaaaaga agcatgggtc attgcaaggt ggcgcaattg ctgatgtaaa ttcgataact 138781 aattcgttaa caagattgca agttgtctct catgaaacag atattaacga ggatgaagaa 138841 gaagcccact atgaggataa acacgtgaag agagccttga agcaaagaca cattggtatg 138901 attgcactag gtggtacaat cggtactggt cttttcgttg gtatctccac tcccttgagt 138961 aatgctggcc ctgtggggtc cctgattgct tacattttca tgggcaccat tgtctacttc 139021 gttacccagt cacttggtga gatggctacg tttatccccg tgacatcatc tatcactgtc 139081 ttttcgaaga ggttcttatc acctgcattc ggtgtttcta acggctacat gtactggttc 139141 aattgggcta ttacttatgc tgtggaggtt tctgtcattg gccaagttat tgaatactgg 139201 acagataaag ttccattagc ggcctggatt gcgatattct gggtaattat tactttgatg 139261 aattttttcc ctgtcaaagt ttatggtgaa tttgagttct gggtggcctc tgttaaagtt 139321 ttagccatta tgggttactt gatatatgct ttgattattg tctgcggtgg atcccaccag 139381 ggccctatcg gtttcaggta ctggagaaat ccaggagcct gggggccagg catcatctcc 139441 agtgataaaa gtgaaggccg ttttctcgga tgggtctcct ccttgattaa tgctgcattt 139501 acgtaccaag gtactgaact ggttgggatc accgctggtg aagcggctaa cccaagaaag 139561 accgttccaa gagctatcaa taaagtcgtc tttagaatcg tactattcta tattatgtct 139621 ttgttcttta ttggtctact ggttccatac aacgattccc gtttatctgc tagttctgct 139681 gttattgcat catcaccctt cgttatttcc attcaaaacg ctggtactta tgctcttcca 139741 gatattttca acgccgtggt gttgattact gttgtatctg ccgctaattc gaatgtttac 139801 gttggttccc gtgttcttta ctctttagct aggactggta acgcaccaaa gcaatttgga 139861 tacgtcacca gacagggtgt tccatatctc ggtgttgttt gcactgctgc attgggtctt 139921 ttggcattcc tggttgtcaa taacaatgca aacactgcat ttaactggtt gatcaacatt 139981 tccactttgg ctgggttatg cgcctggtta ttcatctctt tggcacatat taggttcatg 140041 caagctttaa agcaccgtgg tatttctcgt gatgatctgc ccttcaaggc caaattgatg 140101 ccttatggtg cctactacgc agcctttttt gtcaccgtca tcatattcat ccaagggttc 140161 caagcgttct gtccgttcaa agtttctgag tttttcacat cttacatctc cttgattctt 140221 ttagccgttg tgttcattgg ttgccagata tactacaaat gcagatttat ttggaagcta 140281 gaagatattg acatcgattc cgacagaaga gaaatcgaag caattatttg ggaagacgac 140341 gagcctaaga atttatggga gaaattctgg gctgctgttg catagtcaca gaacctcttg 140401 catgccttca aaatagaaaa aaataaaaaa atagacgttt cattaatcaa aatagcctgt 140461 agagattttg agggattgcc ccaaacttta tgtataatat caccacttat tattcactat 140521 tcatagtatg ttacatcata aggccattgt caccttcggc cagcgatagt actcaaatct 140581 ataataaatt ttccatatta tcctttacgt acttgatagc gtgtataaca gggtcattat 140641 tcacgatatg ttcaactgtt gtcattttcg tgttattgca ctgaaacaaa agaaccctac 140701 caaaaaattc gttagagaaa aactaaaagt acaagatctt atactgaaga cccttcattt 140761 tttaggccca acttctatat taagaagatc cctggaccct gctagaaatt ttcaattagc 140821 ttatcatttt tcttcattgc gagcgttcgt tttcattaag cattcgttct cttcactatg 140881 cataaagcat ccagttcaaa gaaaagcttt gatgatacta ttgaactaaa aaaaaatgaa 140941 caattactga aactgatcaa ctctagtgaa ttcacccttc acaattgtgt ggagttactg 141001 tgcaaacact ccgaaaatat tggtatacat tactatttat gtcagaaatt ggccacattt 141061 cctcacagcg aactacagtt ctatattccc caactagtac aggtcctcgt caccatggag 141121 acagaatcaa tggctttaga agatttacta ttaaggttga gggcggaaaa ccctcatttt 141181 gcactactga cgttttggca gttacaagcg ttactaacgg atttatctac tgaccccgct 141241 tcttatggct tccaagtggc tagaagagtc ttaaacaact tacaaaccaa tctctttaac 141301 acaagttcag gtagcgataa aaatgttaaa atacatgaaa acgttgcacc ggccttagtt 141361 ctttcctcta tgataatgtc ggctatagca ttcccccaat taagcgaagt gaccaaacca 141421 ttagtggaat ctcaaggtag aagacaaaaa gctttcgttt ttaagttggc tagaagtgca 141481 atgaaagatt ttaccaagaa catgaccttg aaaaataccc tactaaacaa gaaaacttcc 141541 agatccaaaa gagttagctc aaatcgcagt tcaactccga cttctccaat agatttaata 141601 gatccaataa aaactaaaga agatgcatcc ttcaggaaat ccagacatag tgaggtaaaa 141661 ttggatttcg acattgtgga tgatataggt aaccaggtct ttgaagaaag aatctcatct 141721 tcaatcaaac tcccaaaacg taaacctaag tatttggata attcatacgt tcataggaca 141781 tatgatggca aaaatataaa cagggacgga agcatttcaa ataccgcaaa ggctctcgat 141841 ggaaataaag gtgattatat ttctccaaag ggacgtaatg atgaaaataa tgagattggt 141901 aacaatgaag atgaaactgg tggtgaaacg gaggaggacg cggacgcttt aaactctgat 141961 cacttcacca gttctatgcc agatctgcat aatattcaac caaggacttc ttctgcttca 142021 tctgcttctt tagaagggac acctaagtta aacaggacca attcccaacc cctttcgcgc 142081 caggcattca aaaacagtaa aaaagcgaat tcttctttga gtcaagaaat tgacttgtcg 142141 caattatcga ccacttcaaa aataaaaatg ttaaaagcaa attattttcg ttgcgagaca 142201 caatttgcca ttgcgctaga aacaatatct caaaggctag ctcgagtacc gacagaagct 142261 agattgagtg ccttacgagc cgagttgttt ctattaaaca gggacctacc agcggaagta 142321 gatatcccca ctttattgcc tccaaataaa aaaggaaagt tacataaatt agtgaccatt 142381 actgctaatg aggcacaagt tttgaactct gcagaaaaag ttccatattt actcctgata 142441 gaatacttga gagacgaatt tgattttgac ccaacaagtg aaaccaatga aagattatta 142501 aagaagatca gtggtaatca gggaggcttg atatttgatt taaattacat gaatagaaaa 142561 gaaaacaacg aaaatagaaa tgaaagtact cttactagca acaacactcg atcttcggta 142621 tatgatagta actcgttcaa caacggggcc tcccgcaatg aaggtctatc cagtacctca 142681 agaagtgatt cagcgtccac agctcatgtt aggactgaag tcaataaaga ggaagattta 142741 ggtgatatgt caatggtaaa agtcaggaac agaacggatg acgaagcgta tagaaatgct 142801 ttagtaatac agagtgccgc aaatgttcca attttacctg atgatagtca agacagaagc 142861 ccagagttga actttggctc aaacttggac gaagtactca tcgagaatgg aattaatagc 142921 aaaaatatac atagccaaac tgacgcttta gcagaccaga tgagagtttc agctgttatg 142981 ttagcacaat tggataagtc gccacaacag ttatcagaaa gtaccaaaca aatccgcgct 143041 caaattattt catcaatgaa ggaggtgcag gataaatttg gttaccatga tttggaagcc 143101 cttcatggaa tggcaggtga gagaaaattg gaaaacgatt taatgacggg tggtattgac 143161 acttcatatc taggtgaaga ttgggctacc aagaaagaga ggatacgtaa aacttcggaa 143221 tatggccatt tcgaaaactg ggatttatgt tctgtaatcg ccaagacggg tgatgatttg 143281 agacaggagg cgtttgcata ccagatgatt caagcgatgg ccaatatttg ggttaaagaa 143341 aaagttgacg tttgggttaa aagaatgaaa attttaatta ctagtgcgaa tacgggactt 143401 gtggagacca tcacaaatgc tatgtctgtg catagtatta aaaaggcttt aaccaaaaaa 143461 atgattgaag atgcagaact agatgacaag ggtggtattg cctctttgaa tgatcacttc 143521 cttagagctt ttggtaatcc taatggattt aagtatagaa gagcacaaga caactttgct 143581 tcttcgttag ccgcatattc tgtcatttgc tatctcttgc aggttaaaga tagacacaac 143641 ggtaacatta tgatcgataa cgaaggccat gtaagtcaca tcgattttgg atttatgcta 143701 tcaaattcac ccggctcagt gggctttgag gccgcaccat tcaaattaac ttacgaatat 143761 attgaactgc taggcggagt agagggagaa gcgtttaaaa agtttgttga actaactaaa 143821 agttcgttca aggctctgag aaagtatgct gatcaaatcg tatcaatgtg tgagattatg 143881 caaaaggaca atatgcagcc ttgtttcgat gctggcgaac aaacaagtgt acaactacga 143941 caaaggttcc aattggactt atcagaaaaa gaagttgatg acttcgtaga aaatttcttg 144001 ataggtaaat ctttgggtag tatttacacc agaatatacg accaatttca acttattaca 144061 cagggtatat atagctgaga aggaaaatag ctgtgacaga actggaaaaa caatttgcaa 144121 atgtccggag aacaaaaaaa ttggaatttt agtaaaagga atatacatat atttatttat 144181 tgccgagaat aatagagcag ctgactcaga aaaagcaagg taaaagaatg agagtaaaat 144241 aaatatgtgg ttaattaacc atacatataa attattatct tattttctgc gtaaagcgtc 144301 aaaccgtttc ttcaactcat ctagttcatc attttcttgc tccttcttag tctttctttt 144361 tgtagttttc ttttctgatt gtttcttttc gatcacttcc tttttgatat ctttcggaat 144421 cttgagctcg ttcttgatat tttcactatt ctgcctaggc tttttaacag tgatagggtg 144481 tttagcatct gcattgtcat tatcgtcatt atctaaggct aaaataggct tttcttcgtc 144541 attatcctcg atatctcccg aggggtcact aaagtctgaa gaaatgttag aagacgacga 144601 agataaggaa ttctccagct tactatatgg cacatcgtat gttttcgcga tttccttcaa 144661 ataaagatca actagttctt cttttggaac tgagggagag cattttttta taatcttttc 144721 agggacatcg atatgatctg ctattactcc attaacaaac tcaacgttta ttttccaggc 144781 catcaaatct ttcaattggc taagttcttt gacttcatca acgaaaagaa tcgcatagat 144841 tagggatctg atagcttcgt taataccatc atccatatgc tctttgacaa gctgttcctc 144901 ggtggagata tcgtttatta cctgcactct agccagtagt aattcacaat atagttccaa 144961 tatctctagt agctcaatat gaatatcgtc atgaattagc gtctccacac gataatgcgc 145021 cttctgttct ttatttgtca gtaacagttg tgcaacctgt cttcgagact gctttgcaat 145081 cgcctgttgc ttttcttgag catatcttaa cctttgaata cacattttca ggcatgtttt 145141 aagcttgatc tataacaata atttggatga tagttttacc cttcttcagt tagtacatcc 145201 tagatctttt gcatactaaa gctttttaaa aattactata aaatataaac atacagtgaa 145261 cggaatcatt gacggagcca tttttagttg tcgtattctc ttatctatct tctatgttga 145321 ctagttctga ttgattagct ggaactaata gtatatataa ttttcacacc ctttggaatt 145381 cagaaggcgt tttttttttc atgaaacaaa acaatagagt gcggatagcc gattcagttg 145441 attctaaaag tatataaaat gcgataagcg cataagcagc cattataaac gtacatctga 145501 gtctagatat atacgtttgt gtagcgggaa acgttaaaaa aaaaaatctt aattatagtt 145561 tatcaaatga ccatatcaac aggatatttt aattcgtcat gttggccctt ggtgtcatat 145621 tcacttaatc cgacaatgcc tccaaacttt aaaaatctat caaaacgttt caatcgtaaa 145681 tcgtcaactt tcttaaccat atctggccaa tagacttcat gtttatactt gaagtctaac 145741 agaccattgt atagagcatc tagttgagat ggctctatgt ggttttcaaa tggttcgtca 145801 aagatagcct tcgccttagt ggcagggtca aggaacggat acatcatctt caaaaaagcc 145861 cacgcaaacc atgggatatt gatcaggaca cacttagcta acctttcagg gtaatgatct 145921 tgcatgacgt tcaaacacat cctagcaata gagatgggtg gagctttatc agtgataata 145981 ccaggttctt tataactttt gaaatctacc aagactgtga tcttttctac accttgggga 146041 gctacagttg tcgcagtttc catcatgtag actaattctt ggacttgtct aaaggaagat 146101 tctgtgtttt gacgaccatt tttcatgtag tatagaggtc ttttagcgtt gtcaaagccc 146161 aaaataacct gtttaccagt ttcgttctca acggcaactt tgtcagctgt taaagggtct 146221 ttgtcctcct taccatgtgt aagtccaatt tctctcctcc ataccaaggt tttggtgaga 146281 ccttttatgg cgttcgcggt gttccattta ttggctctta ggtatcttag aaaacactcc 146341 ctagaaagcc aaaacttctc ccaatcactc aagggtctgt cattggcatg tgtcccattg 146401 tcaaggtcat tgagattttc tggtaatttc agatcatcat cttgaaaatg tcgtaagaca 146461 gctctatatt tttcgttttg atcttcggag atgggttcca gtagaggtgc gttaccatac 146521 ttggcaggag ggtccaagaa tatcttatca catggaataa gtttctcttt aggcacagca 146581 ggcgtatggt cccgttttct tgaaaaaaga cccatttttg ttcttcttct tgtgctttct 146641 ttgtgtgatt tttcagggtc ttttttttta aacaatgatg taaattaaat ctatctaaaa 146701 agcgtgattt ttcccacgaa ttttaatccc tctattgttc tctttccact ccatattgag 146761 tgaaaggaaa aataagaaaa gtaaatagaa aatttatgac gtaggaataa aagtatataa 146821 gtatttaaca aattgaccgt agataataat aatgcgcatg aaattaaatc ctctctttga 146881 tctcttcaat caagatcaac ccattaacca cattagaaca ttttgccaaa tgaagccata 146941 gacgaatagg aagtaattgc acttcttgac ggtcgatttg ctgatggaaa cgtgtatatc 147001 atcgtcttca gcaccggagc ggcttagtaa attgaacttg acggatctta gtaggaatac 147061 gccaaaggca ataaataagt aaaattttat caaaatattc aggttaaatg gcatggtcac 147121 gttggtcaaa agctgggcga gaatcaatgg aacaaatttg tagccgacat agcacaacag 147181 ttcgaccaaa ctgaagcttg gaatcttaga atcgatcaaa agatacaagc caagcttcaa 147241 aatcaacaaa tctaaacaca caaacgccag agtagaagac agtttgtagt acaagtcttc 147301 ggggttgaat gaacccttca gaccttgctg cgtattccag atgagaatat aggtaactag 147361 tcccataata ggcatgtaca tgtctgggga gttcacgtca tcccttggtg gcaaaaagtt 147421 gccagagtcc ataattcgtt gccagttctt ggttccgtta agaaaaggaa ctaggatgag 147481 tttcaattta ttgatgacat aacgggtgct gacttgaaaa tacgttgaaa tttgttgaga 147541 gccggcagcg tttgcagtgg ctttattgac cgtttcttga aactggttaa agttatcctg 147601 accaataaaa ttagaaaatg cgctctgccc tagttggaat gccatcgaac cacgaggatc 147661 ttggaatgga aaaccaccgc cactgccatt tacgtttgca ttcatattcg cattaccttg 147721 gccattcacg ggcgtgttcc tcggaatttg cattggtcgt tgctgttgtg gagtgtggga 147781 aaagcgatcg ttaacgccat tctgctcact tgttgcatat gcgtacggat tataagacat 147841 cttggtatgg gcctttggtt ttcgttttct gctattgata ctcagtagcg aggtcttaca 147901 atcgaaaagt caaaaagatg agttgtagta taaaacaaca gctctggtgt gcaatatgga 147961 tcttgataca gagtctcgga tatgctgttt tagcactgag aaaaagtaat agtaacactg 148021 tcagtgttcg tcaaaggccc aagtttattg tcatttgaat tgtcagaatg gtttattttc 148081 aggtagggta accagaacgc gtaagtttct tgcatctttt accattttaa ctggaagagg 148141 acctatcaaa aagagcatat gatgatgaaa gagcacattc tatcaagata acactctcag 148201 gggacaagta tatgatgttt ggcaagaaaa aaaacaacgg aggatcttcc actgcaagat 148261 attcagctgg caacaagtac aacacactct caaataatta tgcgcttagc gcgcaacagc 148321 tcttaaatgc tagtaagatc gatgacatcg attcgatgat gggatttgaa agatacgtac 148381 cgccgcaata caatggcagg tttgatgcga aggatataga tcagattcca ggccgcgtag 148441 ggtggctgac gaacatgcac gcaacgctgg tctctcagga aaccttatcc agtggtagta 148501 atggcggcgg caattcgaat gacggagaac gtgtaacgac caaccaaggt atttccggag 148561 ttgacttcta ctttttagat gaagagggtg ggagcttcaa gtcgacagtt gtctatgacc 148621 catacttctt tattgcgtgt aacgatgaat caagagtaaa tgatgtggag gaactagtga 148681 aaaaatatct ggaatcttgt ctcaaaagct tacaaatcat tagaaaggaa gatcttacca 148741 tggacaatca ccttttaggg ctgcagaaga cacttattaa gttatcattt gtaaattcca 148801 atcagttatt cgaggccagg aaactcctga ggccaatctt gcaggataat gccaataata 148861 atgtgcaaag aaatatatat aacgttgctg caaatggctc ggaaaaagtt gacgccaaac 148921 atctgatcga agatatcagg gaatatgatg tgccgtatca tgtccgagta tctatagaca 148981 aggacattag agtcggtaaa tggtataagg taactcaaca gggattcatt gaagatacta 149041 ggaaaattgc atttgccgac cctgtggtaa tggcatttga tatagaaacc acgaagccgc 149101 ctttaaaatt cccggattcc gccgtagatc aaataatgat gatttcgtat atgatcgatg 149161 gggaaggttt tttgataaca aatagggaga taatctctga ggatattgaa gactttgagt 149221 atacaccgaa accggagtat cctggttttt tcaccatatt taacgaaaac gatgaagtgg 149281 cgcttctaca aaggtttttt gaacatataa gagatgtacg acccactgtt atatccacct 149341 tcaatggtga ctttttcgat tggcctttta tacataacag aagtaagatt cacggcttgg 149401 acatgttcga tgaaattggt ttcgctccag atgctgaagg tgagtacaag tcctcatact 149461 gctctcacat ggattgtttc cgttgggtga agcgtgattc ttatttacca caaggttccc 149521 agggtttaaa agctgttact caatctaagc taggttataa cccaattgaa ctggatcccg 149581 aattaatgac gccgtatgca tttgaaaagc cacagcacct ttccgaatat tctgtttccg 149641 atgcagtcgc tacgtattac ctttacatga aatatgttca tccttttatc ttttcccttt 149701 gtactattat tcctttgaac ccggatgaaa cattgagaaa gggtaccggt actttgtgtg 149761 aaatgttgtt gatggttcaa gcttatcaac ataatattct tctaccaaat aagcatacag 149821 atcccattga gaggttctat gatggacatc ttctagaatc cgagacttac gtgggtggac 149881 atgtggagtc attagaagct ggtgttttta ggagtgattt gaagaatgaa ttcaagatag 149941 atccttctgc cattgatgaa ttattacaag aattaccaga agctttgaaa tttagtgtgg 150001 aagttgaaaa taagtccagt gtagataaag taacgaattt tgaggaaata aaaaaccaga 150061 taacgcagaa attattagag ttgaaggaaa acaatataag aaacgaacta cctttgatct 150121 atcatgtaga tgtcgcctct atgtacccaa acatcatgac tacaaataga ctacaaccag 150181 atagtatcaa agcagagcgc gattgtgcta gttgcgattt taatagaccc ggaaaaacct 150241 gtgcaagaaa gttaaaatgg gcttggagag gagaattctt tcccagtaag atggatgagt 150301 ataacatgat caagcgtgca ttacaaaatg agacttttcc caacaaaaac aagttttcta 150361 aaaagaaagt tttgacattt gatgaactaa gttacgcaga ccaagttatc cacataaaaa 150421 aacgtttaac tgaatattca aggaaagttt atcatagggt taaagtatca gaaattgtcg 150481 aacgagaagc cattgtctgc caaagagaaa atccattcta cgtcgatacc gtgaaatcct 150541 ttcgtgatag gcgttacgaa ttcaaaggtt tagccaagac ttggaaggga aatctgtcca 150601 aaattgaccc atctgataag catgcgagag acgaggccaa aaagatgatt gtgctttatg 150661 actcattaca attagctcac aaagttattt tgaattcgtt ttatgggtat gttatgagga 150721 aaggctctcg ttggtattcc atggaaatgg cggggattac gtgtttaaca ggtgccacga 150781 tcattcaaat ggcgagagct ttagtagaaa gggtaggaag accattagaa ttagatactg 150841 atggtatttg gtgtatctta ccaaaatctt tccctgaaac ttactttttt acattagaaa 150901 atggtaaaaa gctttatctc tcctacccat gttccatgct gaattacaga gttcaccaaa 150961 agtttacgaa tcaccaatac caagaattaa aagacccatt gaactatata tatgagacgc 151021 acagtgaaaa cacgattttt ttcgaagttg acggaccata taaggccatg attttgccta 151081 gttccaagga agaaggaaaa ggtataaaga aaagatatgc tgtcttcaat gaagacggct 151141 cacttgctga actgaaaggt tttgaattga agaggcgtgg tgaattacaa ctaataaaaa 151201 attttcaaag tgatattttc aaggtctttt tggaaggtga tacattagaa ggatgttaca 151261 gtgctgtagc aagcgtatgt aaccgttggt tagatgttct tgattcacat ggtcttatgt 151321 tagaagatga agacttggtc agtttgattt gtgaaaatag aagtatgtca aaaactttaa 151381 aggaatatga agggcaaaaa tctacttcta ttacgacggc aaggagattg ggggattttt 151441 tgggtgaaga tatggtaaaa gataaaggtc tacaatgtaa atatattatt agttcaaaac 151501 ctttcaatgc acctgttact gaacgagcca ttccagtcgc aatattttca gcggacattc 151561 ccatcaaaag gtcttttctg aggcgatgga cattagatcc atctttggaa gatctggata 151621 tcagaaccat aatcgattgg ggttattata gagaaagact tggatctgct atacaaaaga 151681 taattactat tccagcagca ttacaagggg tttccaatcc tgttccaagg gttgaacatc 151741 cagattggct aaaaagaaaa atcgctacaa aggaggataa gtttaagcag acttcactaa 151801 ccaaattttt ttcgaagaca aagaatgtac caacaatggg caagataaaa gatatcgagg 151861 atttgtttga accaactgta gaagaagata acgccaaaat taaaattgca agaactacta 151921 aaaagaaagc cgtatccaag aggaaaagaa atcagcttac aaatgaagaa gatccactag 151981 tattgccctc ggagattcct tccatggacg aggactatgt tgggtggcta aattatcaaa 152041 aaattaaatg gaaaatccaa gcaagagata gaaagcgtcg agaccaatta tttggtaata 152101 caaacagctc ccgtgaaaga agtgcactag gaagtatgat taggaagcaa gctgaatcat 152161 atgcgaactc cacttgggag gtcttacaat acaaggattc cggtgagcca ggggttttgg 152221 aagtatttgt aacaattaat ggcaaagtcc agaacatcac cttccatata ccaaaaacta 152281 tttatatgaa attcaaatct caaacaatgc cgctacaaaa gattaagaat tgccttattg 152341 aaaaatcttc tgcatcgtta ccaaataatc ccaaaacgtc taatccagca ggcggtcagc 152401 tattcaaaat tactctaccg gaatctgtct ttctggaaga aaaggaaaac tgcactagta 152461 tcttcaacga tgaaaatgta cttggtgtat ttgagggcac tatcactcct catcaaagag 152521 cgatcatgga tttgggagct tcggtaacgt tccgctcaaa agcaatgggt gcgttaggca 152581 agggaataca gcagggtttt gaaatgaagg atctttcaat ggcggaaaat gaaaggtatc 152641 tgagtggatt ttcaatggac attggctatt tactacattt cccaacatca attgggtatg 152701 aatttttttc attattcaag tcatggggag atactattac tatattagtt ttgaaaccat 152761 ccaaccaggc tcaggaaata aatgcctcat cattaggaca aatatacaaa caaatgtttg 152821 aaaaaaagaa aggtaaaata gaaacatatt cttacttggt tgatattaaa gaagatatca 152881 attttgagtt tgtatatttt acagatatct caaaattgta cagaagacta tcacaggaaa 152941 ctactaaatt aaaagaagaa agaggtctgc agtttttact cttgttacaa tctccgttta 153001 tcactaagct cttaggcaca atccggcttc taaaccagat gcccattgtt aagctttcct 153061 tgaatgaagt tcttctaccc caattgaact ggcaaccgac attattgaag aaacttgtta 153121 accacgtttt atccagtggt tcgtggattt ctcacttgat caagttatcc cagtatagta 153181 acattccaat ctgtaatttg aggctggata gtatggatta tattattgat gttctttatg 153241 caagaaaact aaaaaaagag aacatcgtgc tttggtggaa tgagaaagct ccacttccag 153301 atcatggagg cattcaaaat gattttgatt taaatacatc atggataatg aatgattcag 153361 aatttcccaa aattaataac tcaggtgtgt atgacaatgt agttctcgat gttggtgttg 153421 ataatttaac agtgaacaca attttgacat cagcattaat caatgatgct gaaggcagtg 153481 atctagttaa caataatatg ggtatagatg acaaagatgc cgttattaac tcgccatctg 153541 aattcgtgca cgacgccttt tctaatgacg ctttgaatgt tttaagaggt atgttaaagg 153601 agtggtggga tgaggcccta aaagaaaatt caaccgcaga tttgttggta aattccctgg 153661 caagttgggt tcaaaacccg aatgcgaaac tattcgacgg attactaaga tatcacgttc 153721 ataacttaac aaaaaaagcc ttacttcaat tagtaaatga atttagtgca cttggctcaa 153781 ctattgtata tgcagacagg aatcaaattc taataaagac aaacaagtac tcacctgaaa 153841 actgttacgc ctacagccaa tatatgatga aggcagttag aacaaatcca atgtttagtt 153901 atctggactt aaatatcaaa cgttattggg atctgctaat atggatggat aagtttaatt 153961 ttagtggatt agcatgtatt gaaatagagg aaaaggaaaa tcaggattat accgctgttt 154021 cgcaatggca actaaagaag tttctgtcac caatatatca gcccgaattt gaggattgga 154081 tgatgatcat attggatagt atgctaaaga caaagcagag ctatctaaaa ttgaattcag 154141 ggacgcaaag acctacccaa atagttaatg taaaaaaaca agataaggaa gatagtgttg 154201 aaaactcgtt gaacggattt tctcaccttt tttccaaacc actaatgaaa agagtcaaaa 154261 agctttttaa aaaccagcaa gagttcattt tagatcctca gtatgaggca gactatgtta 154321 ttcctgttct tcctggttcc catctgaatg tgaaaaatcc ccttctagaa cttgtcaaat 154381 cactctgcca tgtcatgtta ctttcaaaga gtacaatttt agaaatcagg accctgagaa 154441 aagaactgct gaagatattt gaattgcgtg agtttgctaa agtagcggaa ttcaaagatc 154501 caagtttgag tctcgtggtg ccggattttt tatgtgaata ctgttttttc atttctgata 154561 ttgacttttg taaggcagct cctgaatcta ttttttcatg cgtcagatgt cacaaagcct 154621 ttaatcaagt attgttgcaa gaacacctga ttcaaaaact acgttctgat atcgaatcct 154681 atttaattca agatttgaga tgctccagat gtcataaagt gaaacgtgac tatatgagtg 154741 cccactgtcc atgtgccggc gcgtgggaag gaactctccc cagagaaagc attgttcaaa 154801 agttaaatgt gtttaagcaa gtagccaagt attacggttt tgatatatta ttgagttgta 154861 ttgctgattt gaccatatga gtaagcagta tataacgcga ggttcaatgg cctctttacc 154921 atgaaaaaaa aaaaaaaaaa aaaaaaaagg taaggaaaaa gagtattttc aattcgtttc 154981 tgaacatata aatataaata accgaaaaat tagcccttga acataattaa cactcttctt 155041 tgatatttaa atcacaagta cttttctttt attttcttct taatactttt ggaaataaaa 155101 tgaatgtgac cactccggaa gttgctttta gggaatatca aaccaactgt ctcgcatcgt 155161 atatttctgc tgatccagac ataactcctt caaatttaat cttgcaaggt tatagtggaa 155221 caggaaaaac ctacactttg aagaagtatt ttaatgcgaa tccaaatttg catgcagtat 155281 ggctggaacc tgttgagttg gtttcttgga agcccttact gcaggcgata gcacgtactg 155341 tacaatataa attgaaaacc ctatatccaa acattcccac cacagattac gatcctttac 155401 aggttgaaga gccatttctt ttggtaaaga cgttgcacaa tatttttgtc caatatgaat 155461 ctttgcaaga aaagacttgc ttgttcttga tattggatgg tttcgatagt ttacaagatt 155521 tagacgccgc actgtttaac aaatatatca aactaaatga attacttcca aaagattcta 155581 aaattaatat aaaattcatt tacacgatgt tagagacatc atttttgcaa agatattcta 155641 cacattgcat tccaactgtt atgtttccga ggtataatgt ggacgaagtt tctactatat 155701 tagtgatgtc tagatgtggc gaactcatgg aagattcttg tctacgtaag cgtatcattg 155761 aagagcagat aacggactgt acagacgatc aatttcaaaa tgtagctgcg aacttcattc 155821 acttaattgt gcaggctttt cattcttata ctggaaacga catattcgca ttgaatgact 155881 tgatagactt caaatggccc aagtatgtat ctcgcattac taaggaaaac atatttgaac 155941 cactggctct ttacaaaagt gccatcaaac tatttttaag cacagatgat aatttaagtg 156001 aaaatggaca aggtgaaagc gcgataacca caaatcgtga tgaccttgag aacagtcaaa 156061 cttacgactt atcaataatt tcgaagtatc tgctcatagc ctcatatatt tgttcatatc 156121 tggaacctag atacgatgcg agtattttct ctaggaaaac acgtatcata caaggtagag 156181 ctgcttatgg acgaagaaag aagaaagaag ttaaccctag atatttacag ccttctttat 156241 ttgctattga aagacttttg gctattttcc aagctatatt ccctattcaa ggtaaggcgg 156301 agagtggttc cctatctgca cttcgtgagg aatccttaat gaaagcgaat atcgaggttt 156361 ttcaaaattt atccgaattg catacattga aattaatagc tacaaccatg aacaagaata 156421 tcgactattt gagtcctaaa gtcaggtgga aagtaaacgt tccctgggaa attattaaag 156481 aaatatcaga atctgttcat ttcaatatca gcgattactt cagcgatatt cacgaatgat 156541 tatctccctg gaaggtatcc agagggcagg atacgttcga aacaacaact acgttatata 156601 aatatttata catagtggga tagaatgaac aattatcaag taaaccttgt attttttgtt 156661 cccacgctct acgctctgtt tcttggatat ggtaatcaaa gattaatacg tataaccgtt 156721 attaattcag tccactagaa actattaaaa gcgccctact gtatggaaaa acaatgaatg 156781 aggagactga acggcgcaaa attgttagtt tagttgctct ttttggcggc cggcgataat 156841 gttcttcact tggtattctt accaggattg agcctgattt tgttttgtct tattctttgc 156901 gatgtcttca ttttctacaa aacctctaat ttctccggca atggcccttg aaacgtcttc 156961 aaagacttca aatgtcacgg tgggggttct tttatcttta actaatcgat gaagagttat 157021 tagaatggtt ctaaacttat ttttcaattt tattaacacc ctctcaaatt ccatcacact 157081 ttcatcatcg ttattcattt tcaaaccttt cattaaagta cgaatggtat gtatattctt 157141 ttctagtgtt ggactatgca atccatacga ttctataaca tcacacaaac cttccatttg 157201 tcccaggagc gtaaatcttt ggaatcccac ttgtaaacca tactgtttac cttctagaaa 157261 gctctgcttt atattctcat tctggccctc cagaaaacct tcttggtaat actgttcttc 157321 taggtttagt aaattatcaa aatccatttt tatttgtcca gtgatcttta ctttccattt 157381 actcttcaaa tatgataagt gatttgattt aaacaagttt tttttcattt ttcttataaa 157441 acgatttctc accatgattg agatttttat attagtaaga ttatactgaa aaggcaaatg 157501 gctacatagc caacaaagaa taaaacaata aaacaataaa aaaagacttt tttcttcgta 157561 agcatcctat tgagaatatt aatcatttac ttaagtagct acaatacaaa atagagtaaa 157621 aaactatttc tcttcacttt cattcacaat tgtttgccag atctaacttc ctttccggtt 157681 ttcttaatct tttctaaaat aaaatcgtaa ggaagtgtag tatatacatc tactaattgc 157741 ttttcaaggg atatatctat tttggaaacg tctggttcta atttcgtcaa aactttattg 157801 actgcaccag aacatcccga gcaggtcatg acgacattga attgataatg ttttatctct 157861 gccatctttt gcgctagttc tctcttgtgt cgttggaaat ctcatcctgc aatgttttaa 157921 gatgattcaa gtcatttaag aagctcaaaa atgcactaca agatgtgcca actttgcacc 157981 cccaaaaaaa actaccgcat cacgtgaaat ttattagaaa actgaaaaaa agacaactta 158041 cgcatacgta atacaagatg tacatctatt gcaatgatca tgtaacctat cctacgatta 158101 attatttttt aatcatctag agcagtgcct ctaatttcgt aaatatcatc aatggcattc 158161 cttcgcaggg gagtgtcggc aaacaataac tctatccatt ggattagttc gtctgtcgca 158221 aaaagataaa aatccccatt gtaaaacatc tccataatct cctttaaatg taatggtaga 158281 aacttgccca tagtggcgaa tttttctctc atctttttgt aacttggttc cttcgctaat 158341 aattgtatat cggtgttgtt cactaataaa gatacgagct cacccaaatt ttcggaattg 158401 acctcagaga taatctgcca ttttaatatt tcctttgtca cgcaatcgtt atataaaaag 158461 tttaagaaag acaacaagta acgggaacct tcttcacctc ttattttctg cagtggacga 158521 acaatttcct tcaagatata aggtagcagt ttctcaatgg tggcgtccca cgatggattt 158581 ctctcgttct cacgaaattc ggtcaattga tgcctgatta gttgacagac aatacgatat 158641 ttcatgttca gtttagtttc cagcaggttc cttgttaatt cttttattct atacagcttt 158701 tcatctcgtt ctattagata tctcatatcc acatataatt ggcaccaatt gtgagaaaaa 158761 ttagctgtgc acatggccat atacgatgtc tgcaaaaggt tgtatttgta cgcaaagtat 158821 tgctcatcaa catggctatc tgcaaagcta ctcttgaaat tctgtgaaat tgccaagaac 158881 aattttggta actgtgtaac ttcaatgtgg tctttatcaa gtgatcctac atcatgagct 158941 tttaaatgtt cctttccatt ttctagggaa gcatcatcta tattttcgtc aattgcccag 159001 gcttcatccc aggcattttc ttcttcttct ggttcttttt ccttctcttg atttgttttt 159061 tcttcctcgt cgtcaatatt tacatcaatt tcatcacccc atgcatcggc atcatcatcc 159121 tctacttccc aattccaatc atcatctttg gatacggcat tatggagttc tttttcgttc 159181 tgtacatctg aatcattttt tccaattttt tcgctcatcg tattagtatt gctagtagtg 159241 agctcaacta cttccaaatt ttgccagctc ttttttggat cttcaaatat acttcttatc 159301 tcactaatat gcgattcaag aactttatct agtaataaat tgtagtataa ttgtttgttc 159361 attaacaaat cctgaatctc tttaccggaa tgtgtccaat tggtaacttc tgatttggca 159421 actagtctag ttagtttgtt atttatgaca gaaactagat tttttagcgg tgaatcaagt 159481 gattctaaaa ttatcgatgc attatttttc acaaatttgg taaactccgt attgaacaag 159541 ggacctagct cataacttaa ggtctttctg tctctaaagg ctaatccgtc taacatgaaa 159601 tcgcatactg cttcaaaact tgttaataca gtagacacac aatgttggcc atgcgaagag 159661 gatttagaaa agacaagtat gtttttttcg ttttcatatg agatttcttt accagatata 159721 aaaatagaat ttttgatcat gcttacaatc ctggaaaggt tcatatactc cttcatgatt 159781 gtattcaatt ttgctcttac ctgctcttga gagtcggcac tggtcatatc taaaatgaac 159841 caagcttgat tgtccaaact acccttagga aaatactgtt gggccacaaa atccataaat 159901 gtatcatact caatatgaac cttgtcttta ccccattcca ctgtgggcgt aaattggatg 159961 ctattctcgg taatcttcca aaatccatta gtaagaattt tatacaacgt gctgacaagt 160021 tctaaatgca gtgtgtcgac gtaggtagaa atggactgct ggaaattaaa gctttgctta 160081 agataagcag cattattacg catctttttt cgcaatgact gcaacgaata gtagcagttt 160141 tctagttcta gtatgttcaa attagtttta acttctttta tgagatttaa aaacgtcttc 160201 aaattatcta ggatgttcag ttcgttggct agaattgcct cgcgttgtag taggtcacta 160261 gaatcaagtt ctaactcact gccattggac cttttgctgt cattttttaa tattaaagga 160321 tccttcagta actcgcgtat tatttcacct ttgttaggaa aaagagactc catatccaat 160381 cgagagactt cgtgatttgt aaaagttatg cgaatcaaac cactttttta ctgacaaatt 160441 taacgtaatc ctttaagact atgaaccatg ttatgaaaca tctcttagtt caacatgtcg 160501 cctaattgta tatcgctatt gacgaaagag aagtatcttt catgaggtca ataataacgt 160561 tcaatggtta atgagcacta taatcataaa caaataatga ctttgataat tatataatag 160621 ttatattcgc tcaagttatt ggtggtctta acttctcgag ttcttcgtta caaatagaac 160681 agtaattttg caattgagtg tcattaaacc aaagatcagt catctctata gacaccatcg 160741 agcatttatt tacttcttcc agcaagaatt tttcgtagtc gtcatgcact aattgtttct 160801 ccatgtcttg gagtattcta agttcaatta gcaattcatt tctcctcata gccaactgtt 160861 ttctcgtttc gctatactga tagtccttat tgaaattgtc ctcgctgaac ttctcaaaaa 160921 tggggttatt tgacggcact gacagttgac tacttagcaa gtccgaatca cttatgtaaa 160981 tggctctttg cattgtgaac ttatctgatc caagacggtc gtggaacagt ttttcagctc 161041 tctttattga ccagtagggc actgatgctt tttctgataa aagtatgttt atcataatag 161101 atgctaataa tccgaccacc atcattcgat taatccgtga gaacttttca gcacataata 161161 atagaatacc gataagtatt ctgaagaata caaacgtcaa attcgttact ctgtaaacca 161221 ttagtttgat aaacactagg aaaaggatag tacaagaata cctgatgtca tattgcatac 161281 tttcactctc tttggagttg ccattttttt cagtagcagg ttcttcactt ttgttgctga 161341 gaacacctaa tataccacat agtttgatag ctttgataac ttttccgtgt ttgccaatct 161401 tttccaagta gtaccgtaac acccttctta tcagtaggaa ttcactatga gcaaatttca 161461 aggcccatgt ttggcatatt atttcagcca aagatagctt ttctattgtt ttgccagttc 161521 tactatcaat atattctagt ttgtatagga catgaagcga tgaactgctc gccgtcatat 161581 tcaactttat ttcaagatgg ttatctacat catatgactc agttatgaca aatttaattg 161641 aaagcttcaa taaatgacaa aatggcactt taacgaaaaa aggatctaaa tcgacttcat 161701 aatatttgtt atcaacaatt ttgactatcc tctgtgtagc aaaaatcatt ttagattcct 161761 tatctctatg atatttacca gtatttaaaa aattaccggt catatccaat cgaaatggta 161821 tctttcgaac taattgtgat ttcccgttga tgtctttgtt tttataccaa aaacgtttcc 161881 cgtgttcttc cccatctttt cttgctaaaa acaggcattt tggaaaagca ttcgatttat 161941 ctccaaatag tatgtgggct agtcctttac tagatatttc atattcatga ttgtaagtaa 162001 tcgagtactc tgtctgaagt tttttgagtc tgtttaataa agtagatgca tcatcggaca 162061 tctcccaaaa tgtcacacgt gatttgatga ttttggatac gctggtggcc ttacgatcaa 162121 aggagttttc ttgttctatc ttatataatt cttcttgttt tttttcttga gattcttttt 162181 ccatctgttc aaactttact aaaatctctt cgttactatt tgggtttttt atagccttgt 162241 tttctaacag atattgcaac ttagatgcaa taagcttata gtcagaaaat aaaacgattg 162301 ctttcatttg tagaccgctg gcatcgtaaa gttttaaggt cttctttgat gatctgtcgg 162361 cttctacaga aacgatttca gacaagctga tctttgtaag acagataaat tccatagaat 162421 tcatgtagca ataaatgtag tcttttgtgc aaaagcaggt agctgagaac ttctgctttt 162481 tgttaggaca ccacaatgct tcaaacttga aaagtaaaag ctcttccggt agcttctcca 162541 acctttggtc cggagaaaat actaatgact tgaactgtag atcaagcact ttcaactcat 162601 tagaataata ttgaggatat atagtggagt ttcttattgg aagccttttg ccatcgatcg 162661 ttaataaaga ggagggtttc tttccctttc ctggcaatat agtatattca ctccaatcgg 162721 tcgtgcccca tatattcgca agaacagcat tagggaacca gctacctttt gtgaggaaat 162781 tagacagaat agccagttgt gtcatttttg tagatattgg tgttgttggc atttggaact 162841 gaaacacctt ctcctctcct aaagtcaaaa tatcatattc agagattgag cagttcagcg 162901 tttcatacaa ggactcggtt tctttgtcaa atgttgtgat taattgatct atggaggtgg 162961 ttgtactaga ggcaaattca aaaaacttgg gagaaaatct tttaaacgcc agctcatatt 163021 caagactatc atgttgtata ctcatgacat acttttttgt cgcttcaaaa gctattaacc 163081 atgatttcaa atctagataa tttgaagttt gaaagaccaa cgtgatatcc tttgacatgt 163141 tatcatgtgc ctctgttact ttattaccaa atatttttac ttcaaaacaa aattttcgat 163201 cttcctctgg gtcatagcgc acattagtaa ggaagacacc aaacttatca gtttcctcca 163261 cgtaggtctt cgatggcgac aaaaggaaca taccaaaaac tgcatttttc agaaagcacc 163321 atcttctcac ccatatttcc ctggtaggct ttccaacctg tgttttcata taaagccacc 163381 cagacttttc gggcgatttt ggaggcactt gcgtatcctt tgatagcagc ttcgaggaat 163441 gtattgatct tatattgtaa tcacttgtgt cacttgacgg cgtaattcgt ttcaaggtat 163501 acctatatgc ttgctttttt gcattactga tatcagaatc caatactttc gatccttcga 163561 tggaattttc tacccatatt gcgtaattgt ctaaatactc attaatgcaa ggagataaat 163621 ctattttcct tccagaatct ttcgttataa aaatgcttct tgactttaat actttcattg 163681 actctagtat gaatttatct aagcttaatt ttactgctga tatggcactt atgaggtcta 163741 gggaggcctt aaggtagttt ttttgcactt caaataattg taaggcatca cttttgatag 163801 aagatggctc taaactggtt tttgaaattc ttatagcctg gtaggatgcc agcatactgt 163861 catatttacc ttggtaaaaa tcgaaatttt ttctcacgtt tctgtagggt tcaattgcag 163921 tagtcataag ttctaatagc gcggttgagt ggctagagtc atcacccttt acaatttgca 163981 gtaatttcat agaaaagtca taatagtcct tgttaaaact atcaatcagc ctgggagtaa 164041 acgattggtt actgacaaaa ccgttgctca gcaaggctgg aggaggtaac aattgggata 164101 ggagagtttc ctttgctctt cgaaaatctt caaatgacac cttatatttc tgatcgaaaa 164161 agtcgacagt cttctctatc caatcctcta atgcatccac ccttgtttgg aagaaattta 164221 cggatgcacg aaaggaagga gagtcaattg atgcttcttt gaatgcaacc gatattagcc 164281 ttaactgcct ctttttggga tccctcccgt gaacggacat atttcaagta atgatatatc 164341 tctgcaatat gtcaattgat caacaggtct actcatgcag ctatgtttta gttacaccta 164401 gtagtttaaa atttcacgtg tactttccct gttttgaacg cattagcaat agcgctggtg 164461 tcgttgcgca aattcataat aaaaggaaaa tttgaaaaac ttatgataaa ttgcaaggtc 164521 atcgaaaaca gaagaacaag gttttttcct ttagtaaatg caaaattagt aaaagtgata 164581 gcgtcttctt tgattaacaa gtttcaatct ttgcctttgg ctatgtcaaa gctattttct 164641 actgtcaatt ctgcaagaca tagtgtacca ctaggcggca tgagagatta tgtgcacatt 164701 aagaaactag agatgaatac agttcttggg cctgattcct ggaatcaatt aatgcctcag 164761 aaatgtctac taagcttaga tatgggtaca gattttagta aatctgcggc tacggatgat 164821 ttgaaatatt ctctaaatta tgcagttatt tctcgtgatt tgacgaattt cgtcagcaaa 164881 aaaaagaatt ggggttctgt ttctaatttg gctaaatctg tgtctcaatt tgttatggac 164941 aaatattctg gtgtcgagtg tctgaattta gaagtgcagg cggatacaac gcatattaga 165001 agtgaccaca tatcttgtat tattcaacaa gaaagaggga atccagaatc acaggaattt 165061 gacgttgtta ggatatctga gttaaaaatg ttgactttga ttggtgtttt cacctttgag 165121 agacttaaga aacagtatgt aactttggat ataaagttgc cttggccaaa gaaagccgaa 165181 ttgccaccgc cagtgcaaag cataattgat aacgttgtca agtttgtgga ggaatcaaat 165241 ttcaagactg tggaagctct tgtagaatct gtgtcagctg ttattgccca taacgagtat 165301 tttcaaaagt ttccagattc gcctttggtg gtgaaggttt tgaaattaaa cgcaatcaca 165361 gccacagaag gtgttggtgt aagctgtatt agagagccca gggagattgc gatggtaaat 165421 attccatatc tttcctccat acatgaatcg tctgatatta agttccaatt gtcttcatca 165481 caaaacactc ctattgaggg taaaaataca tggaaaagag cgtttttagc gtttggttca 165541 aacattgggg accgtttcaa acacattcaa atggcgttgc aattattatc aagggaaaaa 165601 acggttaaat tacggaatat ttcgtctatt tttgaaagtg aaccaatgta tttcaaagat 165661 caaacccctt tcatgaatgg gtgtgttgag gtggagacat tactgacccc aagcgaatta 165721 ttaaaattgt gtaaaaaaat tgaatatgaa gagttgcaaa gagtcaagca ttttgataat 165781 ggtccgagaa caatagatct ggatattgtt atgtttttga atagcgccgg agaagatatt 165841 atagtaaatg aaccggattt gaatataccg catcctagaa tgctggagag gactttcgtt 165901 cttgagccgt tatgtgaatt aatatccccc gttcaccttc atcctgtgac agcggaaccc 165961 attgtagacc atttaaaaca gttatacgac aaacagcatg atgaagatac cttatggaaa 166021 ttagttccat tgccttatcg tagtggtgtg gagcctagat ttttgaaatt caagaccgct 166081 acaaaacttg acgaatttac tggagaaaca aacagaatta ctgtttcacc tacatatatc 166141 atggctatct tcaacgctac accagattca ttttccgatg gaggtgagca ttttgcggac 166201 attgaaagtc aattgaatga tatcattaaa ttgtgtaaag acgcattata tttgcatgag 166261 agcgtcatca tcgacgttgg agggtgttct accaggccta actctattca ggcgtctgag 166321 gaagaagaaa tacgcaggtc tatcccatta attaaggcca ttagagaaag cactgagtta 166381 ccgcaagata aagtcatact atccattgat acttatcgtt ccaatgtcgc taaagaagcg 166441 attaaagttg gagtggatat tattaatgat atttcgggag gtttatttga cagcaacatg 166501 tttgccgtaa ttgcagagaa cccagaaatt tgttatattt tatcacacac acgtggtgat 166561 atttcaacga tgaataggct ggcgcattac gaaaattttg cattgggtga ttctattcag 166621 caagaatttg ttcataatac cgacattcag cagctagacg acttgaaaga caaaacagtg 166681 ttaatcagga atgttggtca agaaattggc gaaaggtata tcaaagcgat tgataatgga 166741 gtaaagcgct ggcaaattct aatcgaccct ggacttggtt ttgctaagac ctggaagcaa 166801 aacttacaaa ttattagaca tatccccatt ttaaagaact actcattcac catgaactca 166861 aacaattcgc aagtgtatgt taacctcaga aatatgcccg ttttattggg tccatcgcgc 166921 aaaaaattca ttggacatat cacaaaagat gtggatgcga agcaaagaga ctttgctact 166981 ggagcggtgg tagcgtcgtg tattggtttc ggcagcgaca tggttagggt ccatgacgtt 167041 aaaaattgtt cgaagagcat taaattagca gatgctattt ataaaggttt ggaataaagg 167101 ttagttatat agattaaata tgtaattctg ttttgtaata attttttttc ctgtttcata 167161 ataaagaatc gttaaaaata accaagggag gaaacaagtg aaatgaagta tagaaaagat 167221 atagaaaata aacttaaata ttcagtttac ttgtgcttct tttttcccct ctatgaaata 167281 tagcatgata agtgattgtt cctttgtttt tttcagtgga tgtttcacct aagcctttgg 167341 acaatccttg gaaatatggc cagtttcgtt acagttgtaa caaagcctgt cattttgaca 167401 gtccctggac atgtggccag cttgaccaca agtgtaacat ttcaatccac taattccgtc 167461 ctctttcata cagtccttag ccatatggtt tggaccacca catttataac atgaaacttt 167521 ggagaatctg ctggtcttct ttggttcagg gcattctctg gagatgtggc cggtttggtt 167581 acagttgaaa caacgttgca cagtacattc acttctaacg tgaccggttt caccacaatt 167641 gtaacattgc ttgaattcaa ctgttcttgg catggtacaa tccgtttgaa cgtgaccggg 167701 tttgttacag ttgtaacata gtctttcaga atcacagtct tctgccaaat ggccaatctt 167761 accgcaaacg taacaagctt tttgagacat ctttttcgta ttcttttctt ttttcctgat 167821 ttctgaaggg aaagccttaa aataatacaa tcctcaagtg cccccaaagc agaaagagca 167881 tttctaatcc atcgatgacc ttattacaac tcttgccaaa agagaaaagg aacgaaaaga 167941 aaattttttc agcatttcgt ctatcatgac accacagcag ttcttactat aaagctcaaa 168001 tccctaagcc ataaaggcaa caaacggcaa tatactacct gtttaatcgt gcgtatccag 168061 tcgccatctc ctgctggaat agttatgaac atcgagtttc agttcccgca gacggtcttc 168121 ctctatggca gcttcccatt gctcaattgg atcagagtcg gctactatga taccgtattc 168181 aactgtatcc tcgagtaagt cataggctag catccttaat tcgggatcgt agtaatattc 168241 cttctcgttt aattgttgct ttggatgttt attcggtgtc ttcgacgagc aagatttatt 168301 cgagagattt aattggtaaa tacaaaaaga cgtaagggtt tctggagcca aaacgtagtt 168361 acagaaatct gttatccccc accattttaa ggttgcgggc tgattgtgcg tgagtgccct 168421 tttatatctc ttagcgattt cttcgccaac cctcaattgc cttttcaggc cgtaaaatcc 168481 agcagtaaat ttgtttaaat tcaactttct aaactcatct acggacaagt aagccttttg 168541 tgagtttttg aatgcatttt ttgcttcaaa atagtataca gacgatatct ttccctccaa 168601 tatgtccatt acaatgggca tgaagggttc tacttcagtg agtagctcat ccgaaaacaa 168661 catgggtggt agtttgaact tgctcatgta ttcttccctt acttgaagtt ttttgattat 168721 ctgctcttta gaactcaaac aactttgtaa cgatagcttt ttatcctcgg gaaatgaaga 168781 ggagaagatt tggttatctt caactgccga tagttctgcc tccaagagta attttttacc 168841 gtctaaaaga ttattgttcc tgcatttgat agactcgata tcttcatttt tcaaattctg 168901 tattagtggg atagaaacga ccttctcttc ttctttttct tttcctctga gtgctgcatt 168961 ctttgcggct tgtacttctg aatttggaaa tgacctcgaa agtttatcaa atgtggccac 169021 agtggaaagc ttttttactt caatctcatc ttctgtgata ctgtctattt tgccgcgctt 169081 ttttgagggg gaaaaggcat catggcctga taagtcgtca ctttctctat catgtatgtc 169141 atgttttcct tgtcttttca ttaacagtaa gttatcacca cttccctttt ttgtggaata 169201 aacacctttt ctcctcactc gattaattcc cagaccaggc ccaaccatct ctgtctacgc 169261 aggtcaaaaa tttgtgctaa ggtctcgaga gcacatacag taccctttta atgtgatctc 169321 atcgctacat ttttcaaagc ttcccatttt agcgacgcca tctatatata ggaaaaaaaa 169381 aaagtttagg acgctattta ccacaacaat tgagatgcag cacaaatagg agtatcattg 169441 cctcccaatt ttcaagggag ttttcagaga attactattc catacctatt caattactgg 169501 agttgtcttc agtatcataa agggttttgg attttcaatc gaattgccat ttttttcctg 169561 cttacgttcg atagatagcc aaatgcagtt tatatatatg tatgtagact tgaaggtata 169621 ttaacagtgc ccatgtttct ttggaaagtg tcaaatatcg caaagcataa ccttgaaggt 169681 taacattatt ttctagaaat acacctttcc cactggatat gatgacggaa gaaacaaaac 169741 gttaaattat tgtaccgttg tataaaacag taaccgagca tggacaattc atttttacac 169801 cccaacgacg ccactaacca tgtataggtg tcttgcctaa cttatcatta ttcatagtag 169861 aattaagaaa attaaaagcc ttgcaccaca ggttacgtac ataagatatt atgttaaata 169921 tatatctctt cagtatttct acgtacaaag cttcactcat tgaggtttga ttggtgtaca 169981 gctacataca taaaaaggat caagtgaact attcggcatg tcgacaattg gagctgttga 170041 tattcttaat caaaagacca taacttctga agtggctgcc tcagtgactt caaaatatct 170101 acaaagtacg ttttctaaag gtaatacaag tcatatcgaa gataaaaggt tcattcatgt 170161 cagttcgcgt tctcattcaa gattcacctc gactcccata actccaaatg aaattctttc 170221 cctaaaattt cacgtatcag gttcatcgat ggcgtatagt agaatggatg ggtcattgac 170281 cgtttggttt attaaagatg caagttttga caaatctgta gaagtttata ttccagactg 170341 ttgtggttcc gataaattgg ctactgattt gtcctggaac cctacttctt taaatcaaat 170401 agctgtcgtg agcaattcat cagagatatc cttactctta atcaacgaaa aatcgctaac 170461 ggcatccaaa ttaaggacct tgtcattggg aagcaagact aaggtcaaca catgtcttta 170521 tgatccatta ggaaactggt tattagctgc caccaaatct gagaaaatct acttgtttga 170581 tgtgaaaaag gatcacagct ctgtctgttc tttgaacatc agcgatataa gccaagagga 170641 taatgacgtt gtgtattcct tagcatggag caatggtgga agtcatatat ttattggctt 170701 taagagtggt tatttggcca ttttaaaagc aaaacatggc atattggagg tttgtaccaa 170761 aattaaagca catactggtc ctataaccga gatcaaaatg gacccatggg gaagaaactt 170821 cattactggg agtatcgatg ggaattgcta cgtatggaat atgaagtcac tatgttgtga 170881 attaataatt aacgatttga actctgcggt aacaacacta gacgtctgtc atttgggtaa 170941 aatactagga atttgtacag aagatgaaat ggtatatttc tatgatctta atagtggtaa 171001 tttactccac tctaaatctt tagccaatta caaaaccgat cccgttttga agttttatcc 171061 tgataaatca tggtatatca tgtcaggcaa gaatgacaca ctatcaaatc attttgttaa 171121 aaacgaaaaa aatctaataa cttattggaa agacatgttc gataacacga tgattgaaaa 171181 acgtaggaaa aacaacggtg gaggcaacaa ccacaataaa aggacgagta agaatactga 171241 taggattggc aaggataggc cgagtagatt caactcaaaa aaataagtta cctgatggaa 171301 ggaatgcggt agaaaatgca cattcttttt ctttcattta atgatattta catgtgattg 171361 acgacaacct aatatataaa tatatatgca cgcatatatt ttgtatatgt aacgttaaaa 171421 acgcatctgt ttttgtgatt tcaattatcc gctaaaagaa attctgtttt gttaaagtaa 171481 tcttttggta catattcact gatctcacct tttgtcagcc aagcaaaatc ctcgaatgca 171541 tcatttttcg acgccaccaa atcaaatttt ccagccaaaa tgtgtgactt cacaataaac 171601 tcagcagtcc tatttctctc gtcctgcaaa acacctatgg gcgtagcaga aacagaccaa 171661 gtgtatatct gatcaccgct caacaatttc aattcgttct ctgcgtgtac gtgtaacggc 171721 ttagattcat cagaaagatc gaagttaggg aatttccaag taccgctttt atccttaacc 171781 aaaagatata aggtcctgct caattgtctt tcaaggctct tcatatcatt tgacctatct 171841 gcttccgtta tcctgtcgtt gggaatcacg ggcctattaa catcgtcttt gctttgctct 171901 ttttgattgt tgctaaatgc tactgtactg tcatcagaaa gtttaacttc ttgcttagta 171961 cttctttctc tgccatgttt aatgtccggt atgcctctag gaaaccaaat gccatttttt 172021 ttggagatag gtcctttctg cagggataga aatttgtgtt ctgctacagt accctttttg 172081 aaataaaaat atgccggaaa cgtccacatt agtctctttt ctagttctga ttggtactca 172141 tagtattttt tctctagttc atttaattct gatttaatta tagggattct tgacagtagt 172201 actccgactt taatcttggg gggagcggaa ctggcagttg cagttgcagt agcaagccct 172261 cttttcaaca ttaaatttac cttcatggta ctggataagc gcttatgatt acgtagaata 172321 taaagtttat tgattgttta actgttttct ttcctttttt ttttttcatt ttcattttca 172381 tctaaacctt gaaaaaaaac caggaatacg gtaaaaaaag agaataaaga ataggataat 172441 gctacatttg aaacacagta gttatgtgaa tacataagga tgtccattta acaaaaaaaa 172501 aaaaggaaca taggaaaaaa cagaaattat atatagaggt agattagttt tatgtactat 172561 gagcaaataa agggtggagt aaagatctta gctttgttgt tgttgctgct gctgttggtt 172621 aagcatattc atcaaagaat tcaattgagc agtggggtca aattgttgct gaggtacagg 172681 gggagccgct gcggcaggtc cctgagaagg taatggttgg ttgggggcat aaccatacgg 172741 ttgctgcatc ataggttgca catattgctg tggtggagga gatgccaatg gtgcattgcc 172801 gtagggtact ggagatatcg acgatatgct accagatttg ttaggtttac cagaacgtgg 172861 cccatttctg ccagaatcag taggcatctt ttgagatatt gccttggaag aaacaccttc 172921 accaacgata atatccggtt cttcgaaaac aataccggta acgagaggtt gaccagaagt 172981 gccaccccat tgcgcactta ctgaccattt tttatcagcg tccgtgagcc tgtgcatagg 173041 aataatactg taaccgtgtt gatagtcaca acaatctctt ggaccaaaac caactcccca 173101 cctagttctc aatggcaggg ctccatcttt attgaagttt tgcaaaacat tttcggcctc 173161 atgtcttgaa taaactttca caaaagcgtg ttttctggag ttattcagaa tgacgctttg 173221 tacttcagca aaaggtttta aaacgttagc aaggtcccat tccttcatgt ttagtggtac 173281 cccaccgatg aaaagagtac ggctgtagac tttaatatga tctggtggca atgtagagtc 173341 gtaacttact ggttttggtc tataatgagg attattggaa acattaagct catcggggta 173401 taagtggtga ttgtttgtgc caaatgtcgt attgggggcg cctatgctgt attggtcctg 173461 ggccacagat ggatagcggt ccttcctgcc tgtcgatggc tgagaaaatg gtgccggagg 173521 agatcttgat ctattccttc ttgagttata tctttctctt tcacgttcac gttcacgtct 173581 gctaccatat tcggtaattg tatgggcttg gggaggtgcg actgtaccca cggatgtatg 173641 tgaaggcaaa gttttaaaat gtttctgcag agccgctatt acttggaaaa gagctgcttg 173701 ctgtttggct ggatctgtgg aagtcaaatc agttggaaga cttatgttca agtttaaagg 173761 aggacttttc tttagatttg acaagatttg tttcgacctc tgcttgggat ccagtgatag 173821 ttgttgtgaa gcggtgttcg cggtgttatt cgatatgtcc atagcaaagc attttgacct 173881 gatggcgttc aagtaactct tttgaaacaa gccggacctg tcccaaatgt ctaaaagcat 173941 acgaattttt tccttgtggt cttgattact ttttgcaata gcatcggata gcagttcttg 174001 aattacttcg cccaacgtgt ttatggcatg ggcacaagta ccgggtttgt tgctgctgct 174061 gtttgaattt gatcttgttt catccaagta agctctacct attgaatcga tgatatataa 174121 agaacctaat ttatgagaat cgggacaaag tcttgagtag tctattatca aagatatgat 174181 tttcgattca atatcaatgt gatcaagtgc gtaagtggtt agtttcttaa tacgagaacc 174241 tgaaatacca gatttcaaat ctttgaatga ttccaaggta gctacaaaat tttgaaaatc 174301 gtcgtcctgc tgcattatgg gatgtttagt atgtttgttg ctttccggtt cctttcctgt 174361 aactcgtgct tggagaaaag tactagaaaa aatgtgtaat cagagaaaac tacaatacaa 174421 aaaaatagac aatagtatat ttttcttttg cttgaaatta taggttgtag caatggatac 174481 ggtaacgtaa ctaattgtaa gaagagcctt gattggtgag ttagttgtgt acaatacgat 174541 aatacgatgc gatacgatac gaaaacgata caataaggtt gccgagtact gacttttgat 174601 atgttaaaag catgaaactc gtaaagggaa ggagcgggga gtcatgctaa cgaggaatgg 174661 aacatggagg aaggacgaaa cacttgccct tttatacttt ttctttttca cctcctccgc 174721 tccgaccggt ggcaaaaaaa aaaatcaaaa atgtaccgta tgtaatgacc aataaatcac 174781 caaagacgaa acatttattt ttgccgccga ctttccaatg aatttgctca atttcaggtt 174841 agtggtcata aggatatcta acaagccatc aaaagcataa tgtttttgag tactcgatag 174901 aattatgtat tgcggacttt agtagaatag gaaacaatgc gctatacgtg cgcagtagct 174961 catttcgacc ataaactaat tgtagatttt ttgcgtttct ggtgctattc attgaaacaa 175021 gaaaccgata gtacttccac ttacaatact aatacttgcg gtaatgttac aatccttcac 175081 ttattatttt cggagaataa taaccatgca tcttgcaata ctttcacggc tttgccttgt 175141 ctcgtgcgct agtaactgca gtagaaccca cccatatgac aatgcaaata ttaatctaac 175201 ttagtcaaaa aaaaaaaatg ccttcacctc gtttgtcttc atctgagata aggttccggt 175261 tttcatcttg tccctgtttg ttgcctttgt tcttgcctca tcgcttctaa agcggctttc 175321 aagctttgat ctttaaatgg aaatctttaa ttctaagaag tggtagcaac cattgagagg 175381 caaaaacaag ggaacgacgg aaagcaggca tgagcgctat ctataaatta tctattcagg 175441 gcatacggtc ttttgactcc aatgataggg aaactattga atttggcaag cctctgactt 175501 taatagtcgg catgaatggt tcaggtaaaa cgactatcat cgaatgttta aagtacgcta 175561 ccacaggtga tctaccgccc aacagcaagg gaggagtatt cattcatgac ccgaagataa 175621 ctggtgaaaa ggacattaga gctcaggtca aactggcgtt tacgagtgcc aatggactca 175681 atatgattgt caccagaaat attcagttgc taatgaaaaa gactactact acatttaaga 175741 ctttagaagg ccagttggtc gctataaata atagtggtga ccgcagtact ttgtccaccc 175801 ggtctctgga attagacgca caagtacccc tgtatctggg agttccaaaa gcgatcttgg 175861 aatacgtgat attctgtcac caagaagaca gcctgtggcc actgagtgaa ccatccaatc 175921 ttaaaaagaa gtttgatgaa attttccaag cgatgaaatt tacaaaggct ctagacaatt 175981 taaaatccat aaagaaagac atgtccgtgg atatcaagtt attaaagcaa tcagtagaac 176041 acttaaagtt ggataaagac agatcgaaag caatgaagct caatatccac caattgcaaa 176101 ctaagataga tcagtataat gaagaagtgt ctgaaattga atctcaattg aatgaaatca 176161 ctgagaaatc cgataaactg tttaaatcta atcaagattt ccaaaaaata ctatccaaag 176221 tagagaactt gaaaaataca aaactctcaa ttagtgatca agtgaaaaga ttgtcaaact 176281 caattgatat tctcgattta tcgaagccag atttgcaaaa cttattggca aacttctcta 176341 aagtcttgat ggataagaat aatcagttga gagatttgga aaccgatatt tcaagtttga 176401 aagaccgtca gtcatccttg cagagccttt ctaattccct catcaggcgg cagggtgagt 176461 tagaagctgg taaggagaca tacgaaaaga acagaaatca cctttcatcg ctaaaagaag 176521 ccttccaaca taagttccaa ggcctttcaa atattgaaaa cagtgatatg gctcaagtaa 176581 atcacgaaat gtcacagttc aaggctttca tctctcagga tttaactgac actatagatc 176641 aatttgcaaa ggatattcaa ctaaaggaaa caaatttatc cgacttgata aaatcaataa 176701 ccgtcgattc acagaatttg gaatataata aaaaggacag atctaaatta atccatgact 176761 ctgaagagct tgctgagaaa ttgaaatcat ttaaaagttt gtctactcaa gatagcctca 176821 atcatgaact ggaaaactta aaaacataca aagaaaagct gcaatcttgg gaaagtgaga 176881 atattatacc aaaattgaac cagaaaatag aagagaaaaa taatgagatg attatcttag 176941 agaatcaaat tgagaaattt caagatcgca taatgaaaac gaatcaacaa gcggacttat 177001 acgccaaact aggactaata aagaagtcca ttaatactaa attagacgag ttacaaaaga 177061 ttacggaaaa attacagaat gattctagaa taaggcaagt atttcccctc acccaggaat 177121 ttcaaagagc tgatttagaa atggattttc agaaattatt catcaatatg caaaagaata 177181 tagcgatcaa caacaaaaag atgcacgaat tggatagaag atatacaaac gctttgtaca 177241 atttgaacac cattgaaaag gatttacagg ataatcagaa gtcgaaagaa aaagtgatac 177301 aactactaag cgaaaactta ccagaggatt gtactattga tgaatataat gatgtcctgg 177361 aagaaacgga gctctcctat aagactgcgc tggaaaactt gaaaatgcat caaactactt 177421 tagaatttaa tagaaaagca ttagagatcg ctgaacgtga cagctgctgt tatttgtgtt 177481 ctagaaagtt tgaaaatgaa tcgtttaaaa gtaagttgtt acaagaacta aaaacaaaaa 177541 cagacgcaaa ttttgaaaaa actttgaaag acactgtcca aaacgaaaag gaatatcttc 177601 atagtttaag gctactggag aaacatatta ttacactaaa ttctataaat gaaaagattg 177661 ataattcaca gaagtgcctt gaaaaagcta aggaggaaac aaaaacttcc aaatcaaaac 177721 tagatgaatt ggaagtagat tccacaaaat tgaaagatga gaaagagtta gctgagtctg 177781 aaattcgtcc tttgattgag aagtttactt acttagaaaa ggaacttaag gatcttgaaa 177841 acagttctaa aacgatatct gaggagctat cgatttataa taccagtgaa gatggtattc 177901 aaactgttga tgaattaagg gaccaacaaa ggaagatgaa tgattcttta cgtgaactga 177961 ggaaaaccat ttcagatttg caaatggaaa aagatgaaaa ggtgagagaa aattcaagaa 178021 tgattaactt gattaaagaa aaggaattaa cagtttctga aattgaatca tctttaacac 178081 agaaacaaaa tattgatgat tctataaggt caaaaaggga aaacatcaac gatatcgatt 178141 ctagagtaaa ggagttagaa gcacgtatta tttcattaaa aaacaaaaag gatgaagcgc 178201 aaagtgttct agacaaagta aaaaatgaac gtgatattca agtacgcaac aaacaaaaaa 178261 ccgttgcaga tattaatcgg ttaatagata gatttcagac catttataac gaagtggttg 178321 attttgaagc taagggcttc gatgaattgc aaacaacaat aaaagaacta gaattgaaca 178381 aagctcaaat gctggaacta aaggagcagc ttgatctcaa gtcaaatgaa gttaacgaag 178441 aaaagagaaa acttgctgac tcaaataatg aggagaaaaa cttgaagcag aacttagaac 178501 taattgaatt gaaatcacaa cttcagcaca ttgaatctga gataagtaga ttagacgttc 178561 aaaatgcaga agctgaaagg gacaaatatc aagaggaatc actaagacta agaacaagat 178621 ttgaaaagct gagctctgaa aacgcaggta aattaggtga aatgaaacaa ttacagaatc 178681 aaatagattc attgactcat caactgcgga ctgattacaa agatatcgag aaaaattacc 178741 ataaagaatg ggttgaatta cagacaagat cctttgttac tgacgacata gatgtctatt 178801 caaaagcatt agatagtgct attatgaaat atcatggatt gaaaatgcaa gatataaaca 178861 ggataattga tgaattatgg aagcgtacgt atagtggtac tgatatagac accatcaaaa 178921 ttagatcaga tgaagttagt agtacagtta agggaaaatc atacaactat cgtgttgtaa 178981 tgtacaagca ggatgttgaa ttggatatga gaggacgatg ttccgcgggt caaaaagttc 179041 ttgcatcgat tattatcagg ctagctctat ctgaaacatt tggcgcaaat tgtggcgtaa 179101 ttgcactaga cgaacctacc accaatttag atgaagaaaa catcgaaagt ttagcaaaat 179161 ctttacacaa tataattaat atgagaagac atcaaaagaa tttccagcta atcgtgatca 179221 ctcatgatga gaaatttttg ggtcatatga atgcagcggc atttactgat cacttcttca 179281 aagtcaagag agatgatagg caaaaatcac aaattgagtg ggtcgatatt aacagagtca 179341 cttattgaaa agaccccata atatctacga agggatagac tttgattgat taattagagg 179401 tgctgaaata cttcgtcgac gagtttgtga taacgcttct gttgcttagc catatctaag 179461 tgtatatgat atttaacgca aagcaatttt cttagtaata tgctatcgtt tccaagtcgg 179521 tattcagcaa gagattcgaa tttttcgcta tcattactaa tatctctctc tgttataacg 179581 tcagctagtt gtttcttttc ctttgcagac ttagcaagca cgtaagcacc tttgataccc 179641 atcatatcga cattctcttt aggtttaatt attgctacac cgttgttaac caaggaaatc 179701 aatgataata gtctttcatt tttcgcttga ctaccagata tccttaactc tttgatatgt 179761 atatttgaat tttcattttg aaatgtatca attatcaatt ttgtctgaaa tgataaaaat 179821 tccaagatac aaatatattt atatgtaaga ttcaacattg atgtatcggt ggactcgcca 179881 atgaaagaac cctttatccg tggatctgca aaaggagtcc tatttccctc gtaatcaccg 179941 tagaaaaaca tatctttcgt aagaatatga attgagagac cattgttctt ctcaatgtca 180001 cgaatggttt gttcgagtac ttgatagata tcagcaccat ctttcagaat tttcctggca 180061 catggatgac tctcaaataa atgttcaatt aatttaccag tacacgactg gcccgcagca 180121 taaacagaaa aatcacccct gttgtcaagt atagtatcaa aaggtcccca tactccagga 180181 attctagtat cagagatggt agtaccatac atgtagcagc tagaagtccc ggctatcata 180241 aacaatgatg tttccaaatg aggagaagca actgcgaacc aacttgcata actgtcaata 180301 caactgcgaa ctacagttgt cgaaatgtgc ttattggcaa caagactagt ggttccaatg 180361 cttacattag atggtaaatt tataatgttt ttgtaaaatg aagatgacca gccagatacc 180421 tctccatcat tgcctatacc attaagattt tctcttccca aaagtccttc aatgttccat 180481 tcatacaagc ggctcagttc ataagcaatg tattgatgaa gatcaaagat atgaaaatgt 180541 ttgtctcgta aatgagagta ttcatctaaa aagtacttca atttggggac gcccatttcg 180601 ggtacaaatt ttcctcccaa ataatccaaa agctgttgtg gacattgcat atttagccat 180661 tgacattcgt ttacggcaga agagtccatc caaaatatga cattatcttc atttggatac 180721 ggtatcagca tgttacttgt gcgatccctt tcgaaaatag ctaatgaaca cgttgcagaa 180781 acaccacatg actttacctc atattctcta atgttcagtt tctgaagaca cttttgaagg 180841 gctttaatta tttcagttga tttttgccag aatttccatg acttctttga agaatcctgg 180901 tagtatggga ctggttcctg cgccatttct aacagcgcat cattgtagta attatataca 180961 cctattctag cacttgatga acctacatca attccgatgc caacttgcag actgctattc 181021 atgatttcac ctatataaca cgttggtttc tcatttaaag ttacctttat tgaaaaaaat 181081 aaactgatac atttttaaat ttcagcttac taaggtgcta gaaagccgaa ctacgctatg 181141 aattaatatt gaatttattg cgaagtttaa aattattgta aaatatctat ttgtacatat 181201 gtatcttctc agaaaaaata gcgtatatct atgtagttat ttttgttttt ctcttcctct 181261 catcaggagg accgtcttat attttgctgc tttatagaac catctagcaa aaaaaaaaac 181321 cagagcaaac caaatgctca gtatatacct ctaggtaact ctaacgtctt ggacctcttc 181381 ctcttcttgt catttcaggt agcttaaatg gaactttcat agtggcaatt ttataagaag 181441 ctgcagtact ttttggaatg ccaaaagcct cagcttgagc cactgtggca cctttgacaa 181501 tagcaccaag taccctgaac aaactgacaa ctttggaagg tttcaagttc aattcgtgtg 181561 ctaagggtgt gatttcaaca atgaagttat ccaaatgcat tatgattgcc aagatgtagc 181621 ataagatttt atcttcattt tgtgggtcaa tgaaatagga gcgatccttt gatcttccaa 181681 actgtccagg ctttatcacg gtaaatctgc ttaagatacc atctaccaag atttcaggag 181741 gactgttcaa cctttctaac aacttcgtct tgttattcac gcgtctattt tcgtatacgc 181801 ccagtaatag tgataagtag tatagtagct gtaatttggt catttgtgaa ggttgtgtca 181861 aagagtccaa tttctttgcc acatacttgg aattgttttg gtatgggaac aattccaact 181921 tcttttcctt atccgcttct ttcagaattg atgaaacgcg aataaactgt aattccttct 181981 ttggtattat actttcaatt gggtaaattt gttctacatc agtggcatcg atattggcta 182041 atggagtagg tctatcgttg gaagtaattt catccaattg agcccgagtt ggtaaatcct 182101 tagatgcagt tctcacggaa tccacaatgt caatagcaga atcagtcaac ttatcagagt 182161 caatacggtt tctttctaga tctgcaatag cttttttagc ctttttagta ccaaacgctt 182221 cacccaacgc atttctcaaa gcagatggac gagtatcact cttacttttt atttttggac 182281 cccttagatt cttgcttgac ttggatacaa ctttggaaac aagtacggga gccttgtaga 182341 gttgaatact tttcttttct ggattaaata ggcccacaac atactggttc gaagcttggg 182401 aagaagaatc agtataacct tcgtattcta gtctctcgtt ttcaccgtgt aatacgaatt 182461 cgtccttttc agacttcttt tttttgtata agtcgaacgt agtgtcactg ggagcacgga 182521 agcccttgaa gaaacttccc acggcaacag agggttgatc ttgaacactt tcaatttcga 182581 tttcagaaac agaccttttc acggacatta ctagataaag tgcaaaaggt tgataacgac 182641 tgcaatagtg gtagcaactt aaaaagccct cctaatatca ttagtgttca tgcaagaata 182701 cttactatta aaaatgagat ggaaaatttc agctcatcgc aataaaaaat tttcagcgcg 182761 ggtgaccgca aacatttttc atcgcgaaga gtcaaaagac attatcaatt gaaaagaaca 182821 gtattgctaa ttggcgtcgg tgattaggtg tccggtcaag ttcttattct atgcatgaat 182881 atcttcataa aagccctgag aagatatact ataatgtcta cgccgaagat tgtgcagccc 182941 aaatggaagg ttccaacgcc acaagctaaa gaaactgtgt tgaagttgta caacagttta 183001 acaagatcta aggttgaatt cattccgcaa tctggcaata gaggtgtcac ttggtactct 183061 tgcggtccta ctgtttacga tgcctcccat atgggtcatg ccagaaacta tgtctctatt 183121 gatatcaata gaagaattat tcaagattat tttggttacg acgtgcaatt tgtgcaaaat 183181 gttactgata tcgacgataa aattattttg agagctagac aaaactattt atttgacaat 183241 tttgtcaaag aaaatgatac caaattcaac gccactgttg ttgacaaggt caaaaccgca 183301 cttttccaat atatcaacaa aaattttact attcaaggca gcgagatcaa aactatcgaa 183361 gaatttgaaa cttggttatc gaatgctgat actgaaactt taaaattgga gaatcctaaa 183421 ttccctatgc atgtcaccgc agttcaaaat gctattgaat caatcactaa gggcgattcc 183481 atggacgcag aagttgcctt tgaaaaagtc aaggacgtta cggttcctct attggataaa 183541 gaattgggct ctaccattag caatccagag attttccgcc aacttccagc ttactgggaa 183601 cagaaattca atgatgacat gttatcatta aacgtgctac ctcccaccgt tacaactcgt 183661 gtttctgagt acgttccaga aattattgac tttgttcaaa aaattattga taatggttac 183721 gcatatgcca cttccgacgg ttccgtgtac tttgatactt taaaatttga caaatcccca 183781 aatcatgact atgctaaatg ccagccatgg aataagggcc agttagactt aattaatgat 183841 ggtgaagggt ccttaagcaa ctttgctgat aacggaaaaa agtcgaataa tgattttgct 183901 ttatggaagg cttccaaggc aggtgaacct gagtgggaat caccatgggg taagggtaga 183961 ccaggatggc atattgaatg ttctgtgatg gccagtgata tcctaggctc taacatcgat 184021 attcattcag gtggcatcga tttggccttt cctcaccatg ataacgaatt ggctcaatcc 184081 gaggctcgct tcgacaatca acagtggatc aactatttct tacatacggg ccatttacat 184141 attgagggtc aaaaaatgtc taaatcctta aagaatttca ttaccattca agaagctttg 184201 aaaaaattct caccgcgcca attaagattg gcttttgcct cagtacaatg gaacaatcaa 184261 ttggatttca aggaatcttt gatccatgaa gtaaagtcat ttgaaaactc catgaacaat 184321 ttttttaaga ctattagagc attgaagaac gatgcagctt ctgcaggtca tatctctaaa 184381 aagtttagtc ccttagagaa agaattattg gctgattttg ttgaaagtga atcgaaagtc 184441 cattcggcgt tctgtgataa tttatccaca cctgttgctt tgaagacact gagcgaatta 184501 gtgaccaagt caaacacata cattaccact gcaggtgctg ctttaaaaat tgagcccttg 184561 attgctatct gtagctacat caccaaaatc ttaagaataa ttggatttcc atcccgtcct 184621 gacaatttgg gttgggcagc ccaagctggc tccaacgatg gatccctagg ctcattggaa 184681 gacactgtta tgccatatgt taagtgttta tccacattta gagatgatgt acgttcctta 184741 gctatcaaga aagccgaacc caaggaattc ttgcaattaa cggataaaat tagaaacgaa 184801 gatttgctaa acttgaatgt tgccttggat gataggaatg gacaatctgc cttgatcaaa 184861 tttttgacta acgatgaaaa attggaaatt gtcaagctaa acgaggagaa acatgccaac 184921 gaactagcaa agaaacaaaa gaaattggaa cagcagaaat taagagagca gaaggaaaac 184981 gagaggaagc agaaagctca aattaaacca caagatatgt tcaaggatgt cacattgtac 185041 agtgcttggg acgagcaagg ccttccaaca aaggacaaag acggtaatga tatcaccaag 185101 agtatgacca agaagttgaa gaagcaatgg gaacaacaaa agaagctaca tgaagagtac 185161 tttggtgaag acaaatagaa tactcgtggc ttcgttatgt gtgcaactat tcaaaagtac 185221 gtatatatgt atataccatc tttttttacg ttaaaatagt gaaaaaggaa aggaggaaag 185281 aaaaaactaa tataattaat tgtattatat atgtactttt cattttggaa tgtgaaaaaa 185341 ttccaggcgg aaaaaattga aaaaatcaaa cactgcgctt gtgagaaaag ggaagaaaag 185401 catcctaatg attaggcgct tgatgttgac gacaaacatt tcgaagcata acactgccaa 185461 tgatgagtga ccaagaaaac gagaacgagc agtatgtagg attgagctct gcagggcatg 185521 aaatggaaaa ataaagcaac ccattatact aacaatatgc acttagcaag tgcggtagat 185581 ggtcagtgca aaagcattct taggattggc taaatgcgaa gaagaagtgg acgctattga 185641 acgtgaggta gaattataca gattgaacaa aatgaagcct gtttatgaaa agagggacgc 185701 gtatattgac gaaattgcag agttctggaa aattgtgctt tcacaacacg ttagttttgc 185761 gaattacata agggcttcag attttaaata cattgacact atagataaga tcaaagtaga 185821 atggctggca ttggagtctg aaatgtacga cactagagat tttagtataa cattccattt 185881 ccatggaatt gagggagact tcaaagagca gcaagtcacc aaggtgttcc aaatcaaaaa 185941 aggcaaagat gaccaagaag acgggatact gactagtgag cccgttccaa ttgagtggcc 186001 ccagagttac gactcgataa acccggactt gatcaaagac aaacgcagtc cagagggtaa 186061 aaaaaagtac agacagggaa tgaaaaccat atttggctgg ttcagatgga ccggcctaaa 186121 acccgggaag gagttcccgc acggcgactc attggcgtca ttgttcagtg aagagatcta 186181 ccctttttgt gtgaagtact atgctgaggc ccagagggac ttggaagacg aagaaggaga 186241 atccgggtta agcgcagatg gcgacagcga ggatgacgat ggcagtctcg gtgaggtgga 186301 cttgccacta tccgacgagg aaccaagctc taagaaaagg aaagtttagt agtctaggtc 186361 cggagcgggc ttggacaacg gtttccctcg ttgcgacatt gctctttttt ttgttgagtc 186421 tggagttctt ctttgttgtt tagttacctt aaacttactc attggatcat ctttaagcaa 186481 ttttgacttc ttcttctgcg aacttatgga tgttgcggca ccagaagcgg aaatagtagt 186541 ggccgccctt acaggcggtg ttgcaggttg gtttagtata gatgaatcta gttttttctt 186601 acctaataaa tagtcttcct tttcgtcact cagttttgca tcctgataca tccattccaa 186661 gcccgacttc ttcaaagcca agtcattctt gagagtctcc ggcttatcct tgctcgattc 186721 gttcagcagt tcatttagtt ctcgttcttt ttcaatttct ttcaatcgcg tgttaagctt 186781 ctgctgttcg gtaattagat cctgttcggt ctcccatact ttttttctat ttttcataag 186841 cttgggattc catgatttca acagattcaa atcgcccgac cccatgataa tgtactctcg 186901 atttggcctt tcttccctgt actcaaaact gaacgctcat ctcttttgag aagctgcatg 186961 ctacgtacca cttgttctta tatctctgta tgtaagcccg cggcgggaga agaagaaaaa 187021 gaaataaaaa aagatgagat gttatattat atattatagt gtaaatatgc acttggactt 187081 aaataactaa acagttacgt tttatatagg ataacaacac taagaaagaa agcgagcagc 187141 gagtaagcga ctcggcgtaa gccttgaact taaaacccat gaattttaat gttcttcttt 187201 tgcaatccca gttgggagat cataaattcg caaacctttg ctctttggtc accctgcaac 187261 tgaataatct cccccatttc tggatccttg acaatgttac cattacatgc aaagtccttc 187321 tttaggacct taagaattct ctttaaatca tattcctctg ggacaccttg caccgtagtt 187381 aaagtttttc taccatttct ctgttggata cgaatatgaa tatagtttga agtggcggtt 187441 tcgtcgtctc ctgtgtcggc gaaaggatca aatgatttca gattctcaat ggacatacga 187501 tttgcttcag ctatattaat atattccttg tcttttttga aaaagaatag aaaggagaaa 187561 acccccagca cgaaacgaaa acaacaagta gctcttctct tgttttgtcc ttttgcagtt 187621 tgcttttatc cctgtgatga aaaaaaaaaa aactaaaatt ttttgccggc gcatcgaaaa 187681 aatctgttac ccgacccgtt attggtgata atacccattt ttaacgcgat cacatatcat 187741 aaactgcagt gagagggtcg tttacagtag ttatagtacc gaaccaaaag actggaacca 187801 tgtacacatg atccttttac gggtactttt tattgtaatg taggtcggtg cgttttgtac 187861 gacgacgcag cggctgctcg tataaaatga cgcggtcgcg cgccgtttga cgtcctatag 187921 gagaatgcca aaaagggtgt tttgctggaa aatatacata tataaatata tataaagaat 187981 agtgaaacaa tagaaatatt agtaatacag ccatagcagt agtagtgata gtactagcag 188041 ctagaacagg atgtccagaa tagattcaga tctgcagaaa gcgcttaaaa aggcgtgttc 188101 cgttgaggag accgcaccta agagaaagca cgtacgcgca tgcatagtgt acacatggga 188161 ccatcagtct tccaaagctg tttttacaac ccttaagacg ctgcctctgg ccaatgacga 188221 agtgcaactg ttcaagatgc ttattgtact gcataagatc atacaagagg gacatccgtc 188281 agcgctagct gaggccatcc gggataggga ctggatcaga tctctgggta gggtacattc 188341 tggcggttcg tcgtacagca aactgattcg ggagtatgtg cggtacctgg ttttgaagct 188401 ggactttcat gcgcaccata gagggtttaa caacgggacg tttgagtacg aggagtatgt 188461 gtcactggtt tcagtttccg acccggacga agggtacgag acgatcttag atttgatgtc 188521 gttacaggat tctcttgacg agttctcgca gatcatcttt gcgtcgattc agtccgagag 188581 gagaaatact gagtgcaaaa tttcggcgct gatcccgttg attgcggagt catatggtat 188641 ttataaattc atcacctcga tgctgagagc tatgcacagg caattgaatg atgcggaggg 188701 tgacgctgct ctgcagccct tgaaagaacg gtacgagttg caacatgcaa ggctgtttga 188761 gttttacgcg gactgctctt ctgtgaagta cttgaccacg ttagtaacca ttccaaaact 188821 acccgtggac gctccagacg tatttttaat caacgatgtg gacgagtcaa aagagattaa 188881 gttcaaaaaa agagagccct ctgtaactcc agcgcggacg ccggcacgga ctccaacacc 188941 aacaccacct gttgttgctg agccggctat ttccccacgt ccggtatctc aaaggactac 189001 ttcgacgcct acgggttact tgcaaactat gccgacgggt gccaccactg ggatgatgat 189061 ccccactgcc actggtgcag ctaacgccat ttttccacag gcgacggcac aaatgcagcc 189121 ggacttctgg gccaatcaac aagcccagtt tgcgaacgag caaaaccgtc tcgagcaaga 189181 gcgtgtgcaa cagttgcaac aacagcaggc acagcaggaa ctgtttcaac agcagttaca 189241 aaaagcacaa caggatatga tgaatatgca gcttcaacaa caaaaccaac atcaaaacga 189301 tttaattgcc ctcaccaatc aatatgaaaa ggaccaggct ttattgcagc aatatgacca 189361 aagagtgcag cagctggaaa gtgaaatcac aacgatggat tctacagctt ccaaacaatt 189421 ggctaataag gacgagcaac taactgcatt gcaggatcaa ttggatgttt gggaaagaaa 189481 atatgagtct ttagccaagc tatactccca gttgcgtcaa gagcatctaa atcttttacc 189541 tcgttttaaa aaactgcagt taaaggtgaa tagtgcgcag gaatccattc agaaaaagga 189601 acagttagaa cacaaattga agcaaaagga tttgcaaatg gccgagttgg ttaaggaccg 189661 tgacagggca aggttagaat tagaaagatc cattaataat gcagaggcgg acagtgcagc 189721 ggcgacagca gcagcagaaa caatgactca ggataaaatg aaccctattc tggatgccat 189781 attggaaagc ggtatcaaca ccatccagga atcggtctat aatctcgatt ctcctttgag 189841 ttggtcgggt ccgctgactc cacccacttt ccttttgtcc ttattggaaa gtacttctga 189901 aaacgccact gagtttgcca ccagtttcaa taatttgata gtagacggcc ttgcacacgg 189961 cgaccaaaca gaggtcatac actgcgttag tgatttcagt acttcgatgg ctacactggt 190021 gaccaattca aaggcgtacg ccgttactac attacctcaa gaacagtctg atcaaatttt 190081 gaccctggtg aagagatgtg ccagagaggc ccaatatttc ttcgaggatt tgatgtctga 190141 aaatcttaac caggtcggtg atgaggagaa aactgatatc gtcatcaatg ccaacgtgga 190201 catgcaagag aagttgcaag agctatcttt ggctatcgaa ccgttattga acatacaatc 190261 tgtcaaatca aataaagaaa cgaacccaca ttctgaattg gttgccactg ctgacaaaat 190321 tgtcaaatcc tcagaacact tacgtgttga cgttcctaaa ccattgttgt cattggcatt 190381 aatgattatt gatgctgttg tggctttggt aaaggctgct attcagtgcc aaaatgaaat 190441 tgccaccacg acaagtattc ctctgaacca attctacttg aaaaacagca gatggacaga 190501 aggtttgatc tccgcggcaa aggctgtggc aggtgcaacc aatgttttaa tcactactgc 190561 tagtaagtta atcacttctg aagacaatga aaacacatca cctgaacaat ttatcgtcgc 190621 ctccaaagaa gtggccgcat ccacaataca attggtagca gcatcgagag tgaaaacttc 190681 catccactcg aaggcccaag ataaattgga acactgttcc aaagatgtta ccgatgcatg 190741 cagaagtttg ggtaaccacg tcatgggtat gattgaagat gatcattcga cttcgcaaca 190801 gcagcaacca ttggacttca catccgaaca cacattgaag actgccgaaa tggaacagca 190861 agtggaaatt ttgaagttag aacaatcctt gagcaatgcc aggaagagat tgggcgagat 190921 aagaaggcat gcctactata accaggatga tgattgatca tgaattgtac tttttatata 190981 taaagataaa cgttaatata aatatattta tttgaagacg tcttttacgt ttttctgtat 191041 ctgattggta tatgcgttct cgtccgggga cattttttct ttttttggtg cggcgaatgg 191101 aaataatcgc gataatgaat atgcaaggaa caaagaacag acaccccacc cttattatca 191161 tatcacatct ctgtaggagt ctaccatttt gcttctattg taatctttgc gactttattt 191221 caactcacca ttcatacaaa atttctactg ccgtttaaaa taaggaaagc ataaagatta 191281 aagcaaatta agaggaaccc tttttttttt tgatttcgat acaatggcat tttggttacc 191341 tcaaaatata caaaagcggc tgcttcttta cgtccttcag caaatttcgc tgttctccaa 191401 tatagattta tctaacttgg acgtttctat agggtctaag tcacatttct cgttccatga 191461 tgtgaatctg tcacttgatg atctcaacat tccaaacgtg caaataaacg aaggcatagt 191521 tgacgagctt gtgttaaaat taacagtttc tggcggtgtg gaaatcgatg ggtctggttt 191581 aagatttatc atgacacctt tatattccag tggctcacag gaacttcact cagatttttt 191641 ggttaaaagc atccaagatc ttacgaattc gatgttacaa tttagtgatc cattgaccac 191701 atataatagg tacaaagaag atgacattag ctcttcagac agtagtagtg atctcaactc 191761 taatatagaa gcttcaaaac cagccgcaaa tggttcttat actcttcaaa atatgcggaa 191821 caaggccctt aatgtagcct tagcgaaatt gaaaatagca ttaaaggacg ttaccatacg 191881 tttcatagtg aatgatagag atccttccga taacattgtg gaggttcatc tagaaagcat 191941 acaacttatt actacagacg caaatttacg acatataaac attgaaaata tcaccatttc 192001 ctcaatacaa aaacaagctg tacccgactc tcctgtgcat cctttcaata atgacgatct 192061 gtcacaaagc gtttatttat caaaaatgga ggctacttca ctttatatga gcgccatgga 192121 agagcaatca aatgaagacc ccagtgaacc ccaagttaca caagaagaac aagagaatga 192181 taagtgcaag gaatctttaa tggaaataaa taatttgaac atagctttta agggtttatc 192241 atcggtcaat gatctcagaa tgtctaatat tgttattgat attcaggatg ttcatttagc 192301 gatacacaaa attgtcgaaa tcaaaaactc cactttgaag aatattatag atatcattgt 192361 tacacatttg gatgccaatg aaagcttttc ttgccaggat tcccaaagtc cttcacctga 192421 caagcaggaa ccatcagctc tttcttctgt tgatatcaaa tgtatatact taaacttagg 192481 ccaagatatc acagtaattt tgaagagctt taaattagag caaaaggaaa ataattcatt 192541 ggcattttct ttaggctcat tttattctaa ttcgagtcca ttgacaatta gccataaaac 192601 taagccattg ctcactggag aacaaacccc tcaaagcatc gcattaaata tgggcgacga 192661 actagatatt attatcagtc atgatggcat tgcgcatttc tttaaaatct ttcagtttgt 192721 ttcaaaatgt atgtcctttt atcagaataa gtcaaaaggg atgatgcctc aaatagcatc 192781 ggatactaaa aggaccgtac aacttacctc aaaagcagtg aagttgtcgc ttaagtttcc 192841 atatttttta ttatgtttcc aggtttcacc cttcatttac gactctaacc gtgagttgta 192901 cattgagctt gtagacgtat ttaaaaaact accttctcgg tgcacgaaaa tattgacaat 192961 gtcgagcatt acgatctcga acttgcaatc ccctctacaa ctgggttcat atgacgatac 193021 tttgaaagaa gcgctaattt atagttctgt ccatgcaatc atcaaagaag tgatatttaa 193081 cgaagaatat tctggaatag tacaattagt cgaagatatt tctgcgtttg gaaaactttt 193141 cacggattca aagaacagtg aatgtacagg aaagtctaaa agcaagagag gctccttttt 193201 gcagagaagt gtcagagtac ttaattcttc caggttcgtt tacaagcaga gtttatccgc 193261 taatttttct ctcaagatag attccatgaa gttaaaagta tcagaaatta tagggccgca 193321 atttggttct gtggaagcat tactatcaaa taatttcttt gcgattacgg atgactctca 193381 aattgtatat tttacaaaga acttaaaggt agaaagaaag acaccgtcat tattagagcc 193441 acaagaaatc atgtcagtag ttttgaataa agcagttaac gaacctgtac tatatgttca 193501 tagaagggcg aatggaaagt taaaagtcat ttttaacaac attcgcatac attactatgc 193561 aaggtggtta gaaatactaa agaaaaacat cggcccggat aatgccagtt caaaagatga 193621 acctgtttca caaaagctta gtaaaaaaca accgacttca ggatttccct gggaactcaa 193681 atgtctggac tgctctctaa ttctgcaccc tttcagatta aaaagtgtaa tggtcattgt 193741 acttgacaat ctaacaactg gtggaagttc atttattccg caggcaaagc ttctttcaaa 193801 ggcgaataca ctcttcctaa tagatgacta tcagaatttc aaaattcaaa aagataagaa 193861 ctggcctagt ttgataaatt tttatgctgg tcaaggtttc tctgcaatcg gtaaaataga 193921 tactttgaat tttttaataa acaaatccga tggtgccctt ttattggatt gtaaaataga 193981 acaagttggt ctttcattat gcgcggattc ttttcaaact ttttgtcagc tttgtattga 194041 tttaaaatat cctcagacgt ttcctgatga ggaaaaattt agaacgcagt tgaaaaatcc 194101 tatcgatgta ttcaaagaca tcgattgtga tcttttcaat tctgccttca tccgggagaa 194161 caatcatcaa aatgattacg actcagtgca tttggtagac agttttctcg acaaaactca 194221 cgagttcaac aatggtgcca gaagtaaact atcctctcaa ggttcatatg aaatggacag 194281 ttcctctgga actgccacag gtggtatttt acttccccat gagagttatc tagactctgc 194341 tcagccaaaa gaagaagata ctccaccaat cgcctcaaaa gagcaagaaa gggatgtgga 194401 tataaggggt agtatagatg tcgaaaaagt tgttataaaa ctattcgatg ggtatgattg 194461 gaaatatacg cggaaattta tcgctaatac tgttgaaaaa ctggataaag agctcagtaa 194521 agcggaagca agcagttcga aatcaaatgt accccaatca gaggcaaata tttttgactc 194581 tatttatata tctgctaaca aaaacaatgt cacagatttg agaagaaatc ttgatggtga 194641 gatccagggg gttcagaatt ccttctctga tgtctctaaa gttaatttgc gaccttctaa 194701 gcattacaaa gccctgattc aattgaacaa agtacatgtc aatttgaaga attatcgagt 194761 agatgaaccc gatgagtcta actctgataa ttccacagat gttttgaacc gatgtgtagt 194821 ttccatttac gaatttgaaa ttatcgataa tgttcccacg tccacctgga ataaatttgt 194881 aactttgcta aagcacgaac cgtggccaca cagttctccg atgtttcttc tggacctgga 194941 atttatccgg ccgatcgact ttttgcaagc agtggaatta gtcatgcaat taaatgttgc 195001 gcctttacgc cttcacgtgg atcaagacac tttagagttt ctaataaggt tcttagggtt 195061 caaagataaa agatttgaat taattgatga gtatccagat attgtattta ttcaaaaatt 195121 tagcactaat tcaattaagt taagattaga ttataagccg aaaaaagttg attatgcggg 195181 tttaagatcg ggccaaactt ctgaattgat gaattttttt acccttgatg gatccaagat 195241 tattttgaaa agcgtagtcc tgtatggatt aaatggattc gatgaattaa ataataaact 195301 gaaagccatt tggacgccgg atattaccaa aaagcagctg cctggcgttt tggaaggact 195361 ggctcctgtc agatcgttta tggcgattgg gtcaggggtg aagaccctag tcacagtact 195421 aatgtcagaa tacaggcaag aagggcattt gggaaggagt ctgaaaaagg gtggcaatgt 195481 cttcttgaaa acgacaacgg gagattttgt gaaattggga gttaaattaa cttcagggac 195541 acaggcgata ttggagaaca ccgaggaact attcggtggt gttggttcca atggcagggt 195601 gtacgatgca tcgaaatttg gctccgctga tggtgcagac agtgatactg cagctgtatt 195661 agacttggat actttattcg aggaggatca gttagttggt agtaaatatt ccaggataag 195721 agatcatgag cccacggcag tagtcatcga tatgtcttca ccgggagatc acaacgaacc 195781 cacaatagtg agtctgtacg cagatcagcc cctcgacctg cccacgggtt tgaaggaggc 195841 gtatagttca ttagaaaagc atatgcatat tgcgtacgat gcggtatgga gggcaaaggg 195901 acagatgaag gatgataaac ggggagggcc gagcgccgca gcagtttatg ttgctagagc 195961 tgcacctgtg gcaattattc ggccgttaat tggggccact gaggcagtgt ctaagacttt 196021 acagggaata gctaatcaag tggataagac gcataacgag caaatcaatg ataagtacaa 196081 gtccaatcgg actgattcgt aaaaattttt gcagacattt ttgatatata ttcaattcat 196141 attttatctc tttttttttt ttttttttca gacgtggaat ggtgggaaag ccaaaatgtc 196201 actgaccgcg gctaaaagtt aaaaaataca tgagacgaca ttcttttatg tatatatatt 196261 tacacatgta tacaaacaaa tacacacgca agtagagagg agttggtggg gggaagatgc 196321 cattatagag gagaaaagaa caaagagagt gagcttgcaa gataaaatca ctcgaaaaaa 196381 aaaatttcag tgacttagcc gataaatgaa tgtgcttgca tttttctaat tatccttcgt 196441 atcttctggc ttagtcacgg gccaagcgta agggtgcttt tcgggcataa catacttgtg 196501 tttttgcata tattccttca atccctttgg acctcttgat ccgtaggggt aaatttccgg 196561 tgttggaccg tccggacgct ctatgtgctt cagtaatggg gtgaatatgc cccaactgat 196621 atccaattcg tcatctctga caaagttgga atggtcaccc agtagggcgt ctcttatcaa 196681 cacctcgtaa gcctctggaa tccaaaagtc ttggtacctg cttgcgtaag ttagattcag 196741 atctgtgact tgggtagcat ttgacagacc aggggtctta gcattaaact ttaggtacac 196801 agcggcatcg ggctgcactc tgatgaccag ttcgttattt ggaatgtctt tgaagacacc 196861 cgatgcgacc gctttgtact gcagtctgat ctccaccttg gactcattca aagccttacc 196921 ggcacgcatc atgatgggga cgccctccca acgctcgttt tcgatgttga aagtcattgc 196981 tgcaaaagtg acacatttag agtccttgtc tacagtgtca tcatccacgt aggcgggctt 197041 agacccgtcc tcagatttac cgtactggcc caagaggacg tcgtccgtgt cgatgggggc 197101 cacggccttt agaaccttaa ccttttcgtc acgaatagat tccgggtcaa aagacaccgg 197161 tctttccata gtcaagagag tcatgatttg taacagatgg ttctgcatca cgtctctgat 197221 tatgcctata gagtcgaaat agccgccacg gccttcggtg ccgaacctct ctttaaacga 197281 aatctgaacg ctttgaatgt tgtctctatt ccacgaggca ttcaaaaact ggttaccgaa 197341 cctcaagact aaaagattct tgaccaactc tttacccaag taatggtcaa ttctgtacaa 197401 ctcttcttct ttaaagaggg gccccaggtt tttttgcagc tccctggcag aggccaggtc 197461 gtggccgaaa ggtttctcta cgattacacg ggtgatgcca ttctctgcgt acacacgact 197521 cttgatctgc ttggccaccg tcaaaaaaac gcttggcggc aaggccagat agaagagacg 197581 gtgtgggaca tcgacgttgg cacttttctc gaatttctcg atctgcgttc ttaattcgtc 197641 gaagccttca tctgtgtcgt aatttcccga aatgtagctg accatcttga agaactgttc 197701 gaccttagag tcatcggctt caccgtgagg ttttttcaag tggggtagga cacgggactt 197761 caggtcctcc tccatggaca atttggaccg ggcataaccg aagatcttgg tagatggatc 197821 aaggtaacct tctctgaaaa gcccaaataa ggcgggaaaa gtcttcttct ttgccagatc 197881 acctgacgca ccaaagacag atatgacggt atttttttcg aatttgacgg ggccttcact 197941 catcttgcct tatgtggttt tctattctat tggatttact ctttctgtct atacagccaa 198001 ttggagaggg ggaaggggga gaaggagggg tgagtggaga aaagggagag aggggcagga 198061 ggaagccact ttaggtgtta tgtgtcggta tatagatgaa cccacagttt gcttatatat 198121 gggatagcct tggcgagttt tccgtacatt gaagaattcg ccacccttag aaaaggggcc 198181 accacacctt gagccaaaaa tcccacatta ataatattcc attttttttt tagtcatttt 198241 tttttttttc gtctctcttc ctcctccggc cgagccgaaa ccgggctttt agcaccgttg 198301 gaagcttgta tctccgcgta agaccgccgg agtatgcatc ttatagcggt ttttccagtt 198361 cttttccact attacgtggt gcttccagta gcgctactat tattgttgtt cttgctatta 198421 tttaaatgtc actatgtact tgatacacac agtttgtggt gatttcacgc ttatgtacac 198481 gggtgcaaaa ctacacctta cttaccaggt gctcccaaca gagacgagat ccttttcgac 198541 ggcctgcttg acgggcgcga agacgtactc tagcgaaagc gggcgggctg ccgcctcttc 198601 tagcttgggt cccagggtta gaggatctac cattgctagc tcctctccgt gacgcttatt 198661 cagtgtctga accaactgct tccgcttgag actgttttgc tcgccattga gtaggccacc 198721 accgttcatg catgcacccg gacacgcgtt tacctcgatg tagtccgagt ggtagggatc 198781 ggccgtggcg gccgtggcgg ccgccatctc gcgtgagttc gcctttggac ctgttcgtct 198841 cttccgcaga gcggtgatgt tcctcttgcg ctctgacccg gagcccgagg tcagtttacg 198901 caccagattt tggatgtttc taaacccgga aagctcgctg gcggcggcta ttatgcgatc 198961 atcgtgcagc aatcggtact cgacaatgtc gctgtttcta ccctccagaa ctatcatctg 199021 acttcctggg tgtagtcgtt ggacagccgt tacgtactgg taggcatagc caccacaagt 199081 gcctcccaga ttcgacgccc agtggactcg cgggtcccat cccggcggtg atagccgccc 199141 atataaactt gtgtcctcag taagaaacga cttgaagtct aaattcaact cttgtaacat 199201 tgtcactatt tcacgtggcg taatgacaca gtcaatccca tcgtcaagcg attctggcct 199261 tgacgcttct agtttcttgt caaaacatgg catcagcgac agatggtaaa aggactcacg 199321 cgcgatagcg agactctcga acgtagctct gatcaacgag cccgtaattt gctgaggcga 199381 cttgacattg agcagcatag gcaccaactg cggtttggtc ttttccgtgt atataagaaa 199441 tcccggacac acagcagata atagaggctt gcggtccgca ccggtatttt ctttttgttt 199501 cttatgcgca atgatcttct ctacggtttt gctaatcgat atgattctgc ccatctccgt 199561 tccaaccata tacttgcact ggaaatgctt ttggaaaaaa ttcatcaaac acaaatcggc 199621 cgcctccaat gttaagccgt agtactgcgc aagagatagt ctgcattgtg gcgagacact 199681 cacaacgagg aatttgtctt gctgctgcga aagcttcccc cagtttttca ggaaaaccga 199741 gtgactttgg ctactcaaca agatttcttc actagacgtt atacaaccag aacacgcgag 199801 gcagtctgat agggtaatag agaccttctc cagttggtct ggttccgtgc tcacctcgta 199861 ttctccgttc atgttaacgt tatccttctt gcccccgctc acctgggtag gtttgacgca 199921 cgcaagggcg ggactgataa aatcgtttag gtcagactcg gacagtagag cactcatgct 199981 ttcttgtaca cttatcttgt cactcaggaa aaggaagctc cctctcttat ctttccagct 200041 gacaagacaa gtttcttagt catcaccata aaacgctttt atcatttttt tcttcatgcg 200101 atgagcaggg aaaactggta aaaaaagaaa ataggaagtg gaaaagaaaa aactagcgga 200161 aaggcaggca atatgcttta caaacaggca aattttgtct cttaatcctg tgaagaggca 200221 tcgtatattc agtgcttttt gaaatttaga aaatagtcgc tttattgatt atgctacata 200281 tgttattttg ctttagtatg tgtcaaatag catgcaatcg ccgggtagtg agtgacacat 200341 ccttttttcc cctcccacca gaaagtcacc tgctctctta atcaatgggg ttgcatgtgg 200401 taatcaattg ataacgccgg ctgacaagtc gccgacgggc acccataaat aaacgataaa 200461 tagcccttgc tcttttgtta catgcttcct acttctgttt cccggtcctt gtatctcaag 200521 acgtttagaa gccacctttt acgagcacca caaattgttt taaaaagaat gtcctcttcc 200581 atcgatatca gtaagatcaa ctcttggaac aaagagtttc aatccgactt aacccatcaa 200641 ttggcaacca ctgtccttaa gaattataat gccgatgatg cactgttgaa caagactaga 200701 ctgcaaaagc aagataacag ggttttcaac actgttgtct ctactgattc cactccagtc 200761 accaaccaaa aaagctctgg tagatgttgg ttgtttgccg ctaccaatca actgcgcttg 200821 aatgttcttt ctgaattgaa cttaaaagaa ttcgaactgt cccaagctta cttgttcttt 200881 tacgataagt tggaaaaggc caactatttc ttggaccaaa tcgtctcctc ggctgatcaa 200941 gacatcgact cacgtctcgt gcaatacttg ttagcagctc caacagaaga cggtggccaa 201001 tacagcatgt ttttgaacct agtcaagaag tatggcctta tccccaaaga tttatacggg 201061 gatctacctt attctactac tgcgtccaga aaatggaatt ctctgttgac tactaaactg 201121 agagaatttg ccgagactct aagaacagct ttgaaagagc gttctgccga tgattccata 201181 attgtcactc tgagagagca aatgcaaaga gaaatcttca ggttgatgtc gttgttcatg 201241 gacatacctc cagtgcaacc aaacgagcaa ttcacttggg aatacgttga caaagacaag 201301 aaaatccaca ctatcaaatc gactccgtta gaatttgcct ccaaatacgc aaaattggac 201361 ccttccacgc cagtctcatt gatcaatgat ccaagacacc catatggtaa attaattaag 201421 atcgatcgtt taggaaacgt ccttggcgga gatgccgtga tttacttaaa tgttgacaat 201481 gaaacactat ctaaattggt tgttaagaga ttacaaaata acaaagctgt cttttttgga 201541 tctcacactc caaagttcat ggacaagaaa actggtgtca tggatattga attgtggaac 201601 tatcctgcca tcggctataa tttacctcag caaaaggcat cgcgtattag ataccatgaa 201661 agtttgatga ctcatgctat gttgatcact ggctgccacg tcgatgaaac gtctaaatta 201721 ccacttcgct accgcgttga aaattcctgg ggtaaagact ccggtaaaga cggattatac 201781 gtgatgactc aaaagtactt cgaggagtac tgctttcaaa ttgtggtcga tatcaatgaa 201841 ttgccaaaag agctggcttc aaaattcacc tcaggtaagg aagagccgat tgtcttgccc 201901 atctgggacc caatgggtgc tttggccaaa taaatagttt cagcagctct gatgtagata 201961 cacgtatctc gacatgtttt atttttacta tacatacata aaagaaataa aaaatgataa 202021 cgtgtatatt attattcata taatcaatga gggtcatttt ctgaaacgca aaaaacggta 202081 aatggaaaaa aaataaagat agaaaaagaa aacaaacaaa ggaaaggtta gcatattaaa 202141 taactgagct gatacttcaa cagcatcgct gaagagaaca gtattgaaac cgaaacattt 202201 tctaaaggca aacaaggtac tccatatttg ctggacgtgt tctttctctc gtttcatatg 202261 cataattctg tcataagcct gttctttttc ctggcttaaa catcccgttt tgtaaaagag 202321 aaatctattc cacatatttc attcattcgg ctaccatact aaggataaac taatcccgtt 202381 gttttttggc ctcgtcacat aattataaac tactaaccca ttatcagatg aaagtgagga 202441 aatatattac tttatgcttt tggtgggcct tttcaacatc cgctcttgta tcatcacaac 202501 aaattccatt gaaggaccat acgtcacgac agtattttgc tgtagaaagc aatgaaacat 202561 tatcccgctt ggaggaaatg catccaaatt ggaaatatga acatgatgtt cgagggctac 202621 caaaccatta tgttttttca aaagagttgc taaaattggg caaaagatca tcattagaag 202681 agttacaggg ggataacaac gaccacatat tatctgtcca tgatttattc ccgcgtaacg 202741 acctatttaa gagactaccg gtgcctgctc caccaatgga ctcaagcttg ttaccggtaa 202801 aagaagctga ggataaactc agcataaatg atccgctttt tgagaggcag tggcacttgg 202861 tcaatccaag ttttcctggc agtgatataa atgttcttga tctgtggtac aataatatta 202921 caggcgcagg ggtcgtggct gccattgttg atgatggcct tgactacgaa aatgaagact 202981 tgaaggataa tttttgcgct gaaggttctt gggatttcaa cgacaatacc aatttaccta 203041 aaccaagatt atctgatgac taccatggta cgagatgtgc aggtgaaata gctgccaaaa 203101 aaggtaacaa tttttgcggt gtcggggtag gttacaacgc taaaatctca ggcataagaa 203161 tcttatccgg tgatatcact acggaagatg aagctgcgtc cttgatttat ggtctagacg 203221 taaacgatat atattcatgc tcatggggtc ccgctgatga cggaagacat ttacaaggcc 203281 ctagtgacct ggtgaaaaag gctttagtaa aaggtgttac tgagggaaga gattccaaag 203341 gagcgattta cgtttttgcc agtggaaatg gtggaactcg tggtgataat tgcaattacg 203401 acggctatac taattccata tattctatta ctattggggc tattgatcac aaagatctac 203461 atcctcctta ttccgaaggt tgttccgccg tcatggcagt cacgtattct tcaggttcag 203521 gcgaatatat tcattcgagt gatatcaacg gcagatgcag taatagccac ggtggaacgt 203581 ctgcggctgc tccattagct gccggtgttt acactttgtt actagaagcc aacccaaacc 203641 taacttggag agacgtacag tatttatcaa tcttgtctgc ggtagggtta gaaaagaacg 203701 ctgacggaga ttggagagat agcgccatgg ggaagaaata ctctcatcgc tatggctttg 203761 gtaaaatcga tgcccataag ttaattgaaa tgtccaagac ctgggagaat gttaacgcac 203821 aaacctggtt ttacctgcca acattgtatg tttcccagtc cacaaactcc acggaagaga 203881 cattagaatc cgtcataacc atatcagaaa aaagtcttca agatgctaac ttcaagagaa 203941 ttgagcacgt cacggtaact gtagatattg atacagaaat taggggaact acgactgtcg 204001 atttaatatc accagcgggg ataatttcaa accttggcgt tgtaagacca agagatgttt 204061 catcagaggg attcaaagac tggacattca tgtctgtagc acattggggt gagaacggcg 204121 taggtgattg gaaaatcaag gttaagacaa cagaaaatgg acacaggatt gacttccaca 204181 gttggaggct gaagctcttt ggggaatcca ttgattcatc taaaacagaa actttcgtct 204241 ttggaaacga taaagaggag gttgaaccag ctgctacaga aagtaccgta tcacaatatt 204301 ctgccagttc aacttctatt tccatcagcg ctacttctac atcttctatc tcaattggtg 204361 tggaaacgtc ggccattccc caaacgacta ctgcgagtac cgatcctgat tctgatccaa 204421 acactcctaa aaaactttcc tctcctaggc aagccatgca ttatttttta acaatatttt 204481 tgattggcgc cacatttttg gtgttatact tcatgttttt tatgaaatca aggagaagga 204541 tcagaaggtc aagagcggaa acgtatgaat tcgatatcat tgatacagac tctgagtacg 204601 attctacttt ggacaatgga acttccggaa ttactgagcc cgaagaggtt gaggacttcg 204661 attttgattt gtccgatgaa gaccatcttg caagtttgtc ttcatcagaa aacggtgatg 204721 ctgaacatac aattgatagt gtactaacaa acgaaaatcc atttagtgac cctataaagc 204781 aaaagttccc aaatgacgcc aacgcagaat ctgcttccaa taaattacaa gaattacagc 204841 ctgatgttcc tccatcttcc ggacgatcgt gattcgatat gtacagaaag cttcaaatta 204901 caaaatagca tttttttctt atagattata atactctctc atacgtatac gtatatgtgt 204961 atatgatata taaacaaaca ttaatatcct attccttccg tttgaaatcc ctatgatgta 205021 ctttgcattg tttgcacccg cgaataaaat gaaaactccg aaccgatata tcaagcacat 205081 aaaaggggag ggtccaatta atgcatattt aagaccacag ctgaataact ttaaaacggc 205141 agacaaaaca aaaaataggt cgaataaacc ttacctgcct agaaggaatg acagcagcta 205201 ataagaatat tgtcttcgga ttttccagat ccattagcgc aattctacta atatgctttt 205261 tctttgaaaa agtctgcggt gatatggagc atgatatggg catggatgat acttcgggat 205321 acacgaggcc agaaattgtg caggctgggt cgaaatcttt ccactggctc tgcactttgg 205381 gattcttgtt gcttttacca tccgtggtga cgtgcctttc gttcgctggc aggatatatt 205441 cagctaccct cttacaatgc acttgtgccg tttacgcttt cttagaagct gccgtattaa 205501 gatttcaaga caatgatggg gtagaaaata gaacttcaag gggaaccgca tggtttttgg 205561 tgggacttac ttggataacc ttattctttg gtggattagc tggaggaact ggtttcttag 205621 tgaaaagcaa gaggttgcaa acgttcatat caaatgcagg tgagaaaagg ttgtcatata 205681 tccatcgtgg tttatccttt ctaactgttc taacaggttg ggttaaagtc tgtttggcac 205741 ctgttgcgct ctttgggttt tgtagagagg cacacacagg gcaatgcatc gctcatggta 205801 tcatgggatc cgcgtttgtg ttgtacgggt tcatttatgt actggttttg gttataccat 205861 ggattcgcag tgcccaaacc tcatattcac aggattacgt cgacagttgg gttatgtgca 205921 tatggggcgt tgtaaatact tttactgaac acaggtgggg acgtgaagga tggagtgttc 205981 acgattatca acacacgttt atgggaatta tctggtggac tggtggaata ctcgggattt 206041 tcctttccag aaatggcaga agaacatttg taccaagttt gattattatt ttcaccggat 206101 gggccatgtc tgagcacgcc cagcacttga taattagcac aaaagtccat aatatgtttg 206161 ggctagtttt aatgtgtgga ggcgctttaa gaattatcga aatatctttt ttactacgtg 206221 ataaaagaac gctggacaaa atacattcat tccaatacct tgctcccttt tgtttagtat 206281 gttcaggtct cctatttatg ggcgcaaacg aagaacaact cattttagtg ttgcggttgg 206341 gaggcgacca tagtgcgtac gttctaatta tcgtatcagg cgcatttttg gtctacttct 206401 ggatgattgc atgtttggaa ttctacctat atctacttga aaagggaaaa caaggattcc 206461 ttccgaaatc atacgaactt gaagaggaaa acaataacgt gagctttgag ctagataaca 206521 tatcgaacga agatgtggat gaagatacca ctccctttaa cgtttgaata gtgggcaact 206581 aatgtaatat aagacatttg aaagtccgat cctacaccct ctttgttaga agcattgtaa 206641 ctttattttt ttttataata ctctaaatgc ggaactgtat acactttgca cagtttgtat 206701 tcaaattgtt tgcataaata tataaaaatt gccacgaaca cttttagatt ccttcgttag 206761 tctcctttgt atattgccgt ttgcaggctc atgatgataa atctcgctat ttcggtgaag 206821 aaaaaaaaag ctagcttcga acttttcaaa agaagtataa tttcatttca aaaataaggt 206881 ccaaagaaaa gaaactagca gacctgacct tctgttggta aatattagta tgatgcttgg 206941 agagcattta atgagctggt ctaagactgg tattattgca tacagtgact cacagtcctc 207001 aaatgccaat atttgcctca catttttaga atccataaat ggaataaact ggcgatttca 207061 tacgccgcaa aaatatgtat tacacccgca attgcacgaa gttcaatacc aagaaagtag 207121 tagtactcta agcactcact cgacaacaac ttctgtcaat ggatcaacta cagccggggt 207181 tggaagcact ccaaacttcg gaggcaacag caacaagtct cctccacagt tcttttataa 207241 tatatcttcc attcattgga acaactggtt tagtttacca ggtgacatgt tggctgtatg 207301 tgacgaatta ggtaacatga ccatgttaat tactggacaa cgtcctgatc gggccactac 207361 atacgaaaag ttaacgatgg tatttcaaga taatgtttac aaaatttata accacgttat 207421 gcctttaaag cctgtagaca agctaaagcc catgaacatt gaaaggaaac aaacaaggaa 207481 agaatacaat acatccatct tggaatttcg ctggctcacc tcttcaaaat ccgtaatcgt 207541 ttctcaattc tgcgcatttg atagtagttc taatacatat agaagcagag cacagcaagt 207601 gcctccatat ggtgtgtacc atccaccctt tataaaatat gcgtgcttgg caataaggaa 207661 aaacggtcaa atagattttt ggtaccaatt ttcaaactca aaggatcata aaaaaataac 207721 gttacagctg ctggacactt caaatcaaag attcaaggat cttcaatggc ttgaatttgc 207781 tagaattaca cctatgaatg atgatcagtg tatgttgata accacatatt caaaattatc 207841 taaaaatatc tctttttaca aactacacgt taattggaac cttaatgcga ccaaaccaaa 207901 cgtcctaaat gacccatcgt tgaaaataca atttatatta agcactactt tagatccaac 207961 ggatgatgaa gggcatgtgt tgaagttaga gaacctgcat gttgtgtcta aatcatcaat 208021 tgagaaagat ccctccccag aaattttagt tttgtataat gtttgcgata catcaaaatc 208081 attggtgaaa agatatagac tagctccaac acaactttca gctgagtatt tggtgatatt 208141 gaaaccagat ttaaatatcg atcgaaataa ttctacgaat caaatattcc aatcgcgccg 208201 ttacaacctt cgtcgccaca gtgatatcgt tctcgacaaa aaagtcacct tgataacttc 208261 tgagatgttc gatgcatttg tttcatttta ctttgaagat ggtaccatcg aatcctacaa 208321 tcaaaatgat tggaagttgg agactgaacg acttataagt cagagccaat taggaaaatt 208381 caaaaatatt attgcatccc cactaagcgc aggatttaat tatgggaagc tccctttacc 208441 tccatcggtt gagtggatga aggtttcacc atctatgtgt ggggttatcg ttaaacagta 208501 taataaaaaa tggccacagt tttatgctgc tgttcaaaaa aactacgcag atcctgagaa 208561 ggattctata aatgctacag ctttggcatt tggatacgtg aaaagtttac ataagcaaat 208621 atctgccgaa gacttgacca tcgctgcgaa gacgcacata ctcagaattt cattcttgga 208681 tagaaaaagg gccaaagaat ttattacgac tttgttgaaa agcctatact cgtttttcaa 208741 catttctcct gatgcgccta aagagattat ggataaaata ataacaagta ggccacttca 208801 aaaaattatg ctattgcagc tggaacttgg cagttgtttt tcgcaagaaa atattgaaga 208861 aatggcgaga gttatactct acttgaaaaa tgttttgttt gcgttcaatg gtgtggcgag 208921 aaattttcat tttgcgattg aacaaataag taataattct aaccaacaac aaaacccgaa 208981 gttgttccag actatatttt caaaacagga tctcattcat tcattgattc ctgttgctaa 209041 atggtttgtc aaatttatca cttatttgac ccaagaaatt ttaattttaa taaatgatcc 209101 cacaaacaag gaatacacac tagttcacgg aatatttgga gccaaaatgt ccaggacttt 209161 gatattgtct attcttaacg aaatcaagaa agtcacccaa atagtggcga aatttccaga 209221 aacatcatac ccaattttaa acgagtcatc aacttttttg aaactagtct tatctgaatc 209281 accagtggat ttcgaaaaat ttgaaacgtt tttagttgat gtaaacaaca aatttatcgc 209341 gctatgcgaa caacagccat cacaggaacg tgagttttcg ttgttggtga aagctgaaat 209401 ccccccagaa tatgccaaag tgggagattt cctcctgcag tatgctaata atgcagtgat 209461 ttcccatgcg aatgcggctg cagtatattt tgcagataca agtggcttga aaatatctaa 209521 ttcagagttt ttcaatcccg aaatatttca tttattgcaa ccattagaag agggattaat 209581 tattgataca gataaactac ccataaaaaa tagaacctcc aaatctttta gcaaattact 209641 gtacgacgat gtaacctgtg acaaactgag tgtatcagaa atatccgatg ggaaacttaa 209701 gagatgcagt aggtgcggtt ccgtcacaag agcaggaaat ataatatcga gtgataagac 209761 aattgtaccc actagcatcc aaaccaaaag atggccaacc atgtatacaa gactgtgcat 209821 atgttcaggt atgctttttg agatggacgg ctgattatta gtactatagc atagttttgt 209881 atagaattgt tttaaacatt tcacttctcg acttaataaa aagaaatgag agtgacagtg 209941 tctggaattt ctttcttcta gaataccaag ggtacgcatt tctctcctac ggaattttct 210001 gtgcagatgt cccgatctac gtggcagata gtgaaaactc cgtaggcaaa aggggcatcg 210061 gaaaaacctc ttcaaaaaaa aaggttttta ggctcgaacg agccggagca ataatgttcc 210121 tttgaaaaat agcaatcgtt atgcaaccat tttatatgag tctgcccctc aagggactcg 210181 ccaccggacc gctgcagttg tttgcattca tccacatata agctggttgt gtatgacagg 210241 agaaaaaata cttcattcgc agttgttaac caacagcgac atgtctagcg ggaatgtcca 210301 ccatacgaaa ccgatgatgt acaacgtaac cctgccttcc tacaacagca gtagtatagg 210361 tccagtcgat aatttgaaaa taaacgagag acctggctct catgatcatt ccatgagaag 210421 tgaaatgtca tccaaaaact ccggaagcga ttttatgcca caatctattt cacgttccga 210481 aggtagtgtc taccaggtca agatagatcg tggtgactcc ccgaatacag aaggattcga 210541 ctttaaagtt aatgcaagag atctgctgtt acttcgaatg tcctgggata tcctcctcag 210601 ggagtattta acacctaaag aattaaaagt ttttcaagca cttctgtatt ccaataaaca 210661 tattacttca acagaaagac cctatttgaa tactgctcct gacggtatga tttccaaaac 210721 tattgaccct actgccaggc cacgtaaaac aaaacaaagg gacaatgata acaaggttga 210781 tactgcacta ttttgttcac agttttatga caatttgatt gcaatggatc ccttgttaga 210841 agaatatttt ccatcattaa aacatcaagc agtttcgttc tgtaaggtcc ttgattctgc 210901 tattgacaac cttgaaaacg ttcatgtcct agatgattat attgtgaaat taggaaaacg 210961 ccattccaga attctcggca tcaaaaccgt tggtttcgaa gtaatgggaa aagcatttat 211021 gactacattg caggacaggt ttggatcttt tctcacactg gaactcaaaa atctatgggg 211081 acaactttac tcatatttgg caaattgtat gattactgca gggaaggacc caatggaaaa 211141 gattcaacca gatttttcgt ataatggtga ctctgtggtt ttaaattttt ccattcccaa 211201 acttgcgatg catgatataa gtacagttaa caagctacaa atggtgaaaa ctaaaaacgc 211261 tactatacct cataatataa cacaagtacc gacaaataaa attcctacag aaatactctt 211321 agacaattct tctactccaa taaaaagcga ccgtgaatcg acgcctccaa tctcaccaaa 211381 gggctctgga agtacaaaac caagcatcgg tagcagtacc gtcgtggaaa gtaataccaa 211441 gaaaaataat tatgatgaaa aaatccattt attgcaaaaa actgctcagc agaagaactg 211501 ctcgattatg taactacaac cgtaccatta agtgtataag tttcccaggt tatattatat 211561 attctttaga tcactgcctg ttctttatta cccgcgagct aatctttgtc ttatataggc 211621 gcgtcagcgg agacgcgtca agtcaacttc tctcttctat cgtcccgagt atgaaaaatc 211681 atttcagatt cgaagaaatc agattggctt tatatcttct ttagaacaag acgtgtaata 211741 ttctcacact tagagttgac cccctcaagt tcgcttatta gtacaggttt tgactttgca 211801 aataaacaac aggaaaagcg actcaaataa attgacaaag aaatctcaac aaccagagtg 211861 caaaagccgt acgagcagcg tttttattaa taacgatata tcactacgta ttcaacagaa 211921 tatgtcggat agtatttcag attcaaagtc ctcagaactt ttaaattcta ctttttattc 211981 gtcgacgtcg ataaatacac ttgatcatgc tagaaccttt cgaaattctc tgatattgaa 212041 ggagatatca gatcaaagtc taaattcatc aataaagcca tgcgaatccg tccttgatag 212101 ggatgttgaa agctcagttc tgcagcggtc gtttggagaa agtaatgccc gagactcaga 212161 agtacaaacg gtaaatatga caacttcccc ctcattaagt gcattggctg atattctgaa 212221 cgaaagatcc aaatatgctg accaaaaaac tagaaaggca caaaatattg agtcttccat 212281 aatagaagaa gaagaagagg ccgaagagca aaacaactcg atcaattatc acgaggatat 212341 aactggatcc aggctgtctg tacgagagga agcaaatgaa aacttggcga tgacctctcc 212401 aaaccttatt gacattgacg gatccaatag tattcaagtt gcccctttga gtttaccgtc 212461 tttcgaagaa cctgactttt tgtccactcc tagagtaaaa cctgattctc agggacctcg 212521 gagcaaagtt agtacacgac gtactattct cgaacgagac aacaatttac cagttaagcg 212581 ggaggaaaat actatcatta attcagaaac tgaaagcaca acacatagcg caccattttt 212641 aaaagaggat ccgaaaccct cgcctccttc gagtaaatta tacaacccaa aagttcgttt 212701 aaacaaagca gaagcgcgaa agtatactga ttcttctgcc caaaggacta cttcagcagg 212761 ctcggtactt gaagacactt ctatgcataa aaagaaaaag agtatatttt catttctgaa 212821 gaagaaagaa ccgaaaccag ttattggtaa taatagtgta acgaatgaaa aaaataagat 212881 gtcttcatcg agcactttct caatgaatat tcaaacctct ttaaaaacgc ctgaaaaact 212941 aaagaagaag tctcacagta gcagtagcat tttcaattcc ttcctaaagg gaaaaattga 213001 aacatcagac tcacctcgaa aggaaccaat gaggcaaaaa aaaagaaccc caaaatccaa 213061 ggacaaaaag caagatactg aacaaataat tgacgccgca tcagtgttat ccactgaatc 213121 acctctacta cgaaaaaacc acgacgatac tcccgtgaaa atagatcacg taacgagatc 213181 aattgatcag agaaaaccta ctcctttaaa catggatctc atattgggag gtgataaaca 213241 gataaatacc ccgctacaag aacacgtaag agaagatgat gatgccaaaa atgatcttca 213301 attaccaacc aaggataatt ttttatcact ggactacgaa gcaccctcac cagcattttc 213361 caaacacgat acaggtgagg ttcttttccc aaaatttttg gataatcatg aagtcgactc 213421 gatcgtttct ttagaaagaa caagatctac aaagtctaac aagagaagtt caatgaactc 213481 gcaaagaagg tcattgacag atacgctatc gatcaaagcg caaagtgagg gaatgttcat 213541 cactgaggca tcttctgttg tattatctac tccagacttg acgaagtctc ctgctagcag 213601 cattttaaag aatggaaggt tcgaatactc agataatttc tccagagaac actcttacga 213661 aggtaccacg aatgaggact ttttagatat caaggacgat agtggtccac taaaaaaaga 213721 tgacatattt ttagagtcta ttgaacaaaa atttgaccag ctagtgatgg cctctgatga 213781 agaaaaaact gaagttgaaa gggatgtacc aaaaccaaga gaagaacctc tgaagaagga 213841 ttctgaaagg caaagcgttt ttgcagatga tgataacgag ttaatttctg atataatgga 213901 gtttgcaagt tttattaact tcggtgatga tgatctcaat ctagacctag acttgggaga 213961 tacaacggcc tcatatgcaa cagaaacccc tgaacctgtt ggaaatgatg aagtaaatcg 214021 ctctggtact tttgatacac gaaataacaa agaggatagt tacaaagaaa gagaaactca 214081 atcttattcc gctgctggag ctactacata cggagatgag cgtcaaggtc aattacatac 214141 atttgaacaa gacggaagtg aaataaatga caacgaattt gagaatgaag atttcaacaa 214201 acacatagaa cagcccatag aagttactcc aagaaataat gcatatttac cagaattcga 214261 acccaataga cctgtttcaa tgtcctttaa aggactaaaa gccccaagaa tgaatacttc 214321 ttttattgac tccatgacgc ctgattctcc cgtaaaatca gacttaacaa gtctaggtga 214381 ggtgtatgta aacagtaata atgaccaggg tgtccggttt tcgtcccaga taatacttta 214441 cgacacttat ggagaattcg aatatgatag acatccagaa atttccactt gtaaccagct 214501 tactccacaa ctggctcaaa tgatcaaatt ggaattaaat gagttaaaga gcgcaatgga 214561 agtacacgat gattcgcgat gttacacaca tttttattag agcagaaaac tgggagaaat 214621 ggaaatgaat caaatcatac atatcaagac attctagttt ttataaacct ataatttatc 214681 gcaagaatct tgggtgttat gtgttgtatt tgcggcatca tttcaaaata ccgtctgcat 214741 tacccgtctc cgtcacgtga agtaaaaatt tccaaaaaat attgaaaaaa gaaagaaaaa 214801 taagatccag aattcactga tgatgagctt atggtacggc atgattaact acgcatttgt 214861 atattaaaga ttctttgatt ttttccagag cattgaatac ctcaatctat aagtgtatta 214921 taatggcatg caattttcag tttccagaaa tagcttatcc aggtaaacta atatgcccac 214981 agtacggtac ggaaaataaa gatggcgaag atataatttt caattatgtg cccggtcccg 215041 gaactaaact aattcaatat gaacacaacg gacgaacttt agaagctata actgctacac 215101 tagttgggac agtgaggtgt gaggaagaaa aaaaaactga tcaggaagaa gagcgtgaag 215161 gcactgatca atctacagag gaagaaaaat cagtagatgc atcacctaat gatgtcacaa 215221 gaagaactgt aaaaaatatt ctggtttcag tgcttcctgg gacagaaaag ggtcgtaaaa 215281 ccaacaaata tgctaataat gattttgcca ataacctacc gaaggaaggt gatattgtgc 215341 tgaccagggt gacaaggctt tcgttgcaac gagccaatgt cgaaatttta gctgtggaag 215401 ataaaccatc tccaattgat agtggcatcg gcagtaatgg atcgggaata gtcgctgctg 215461 gtggcggttc tggagcagct acgttctctg tttctcaagc atcatcagat ttaggtgaga 215521 cattcagagg tataatcagg tctcaggatg tacggtctac agacagagat cgtgtgaaag 215581 tgatagaatg tttcaagccg ggagatattg ttagggcgca agttttatca ttaggtgacg 215641 gaaccaacta ctatttgacc actgcaagga atgaccttgg ggtcgtgttc gccagagctg 215701 ctaatggtgc tggtggattg atgtatgcta cagactggca aatgatgact tcaccggtta 215761 caggcgctac agaaaagcgc aaatgtgcca aacctttttg atatgtaaca gcttatctac 215821 agtgcatata gacgcgtata tatttaaaag agggtattcg cttcttcttc tttagattgc 215881 attctttgat ggttaggaaa aagaagcggg aacgtgatta aactttttat tctcttttat 215941 ttattatata ttatagtgca ttatcattat ctatctaaat ttgcctttac acggtactgc 216001 tttccgattt tactgggtaa agaagttttt catgagtacc tcttaaatca acctcactta 216061 aacctacaat accaccgaag ctttgaaacc tcttaaaata atgatctctt ttttcacgcg 216121 cggtttccac cagagctggc caataaacat catgattgta cttgaatttc agatcaccac 216181 catacaacga atctagttcg ttcttaggga catatttaac aaatggttca tcaaaaacta 216241 gcttttcacg ggtcagtggg tcaataaaag ggtgaattaa cttcaagaaa gtccatgcta 216301 accaaggaat attcgtcaaa agtgcttttc ctagtctttc tggataatga gtttgtagaa 216361 tatgcagcac ttctttccct acaccaatag gtgggatttt actattgcca ggtactttag 216421 gaacatcagg gtaatcttta aagtctatta gcaaagctag agagtcttga ccagctggca 216481 taaaatcgat aactctttcc aacatgaaga ccaagtgctg tacctgtctg tgagaagtct 216541 ttgtattttg tctgcccggt ttcaaatata agataggtct agcatcgttt tcgtaaccca 216601 aaatcacctg cttacctgat tcgttctcga cggccaccaa gtcagcagtt attttatcac 216661 catgctcttc acctaaatga ctaataccga attctcttct ccacgctaga gtcatggtga 216721 ttctatcgat acagtctttt agcacccatt tagtagccct taggtaacgt aaaaaacatt 216781 ctcttgtcaa ccatgccttt tcttcttcct ctaagggttt aagatcatcc tccgacttat 216841 ttttttcact tgtataaacc ttcaagtcag ggttactgaa atgttttagc acttcgtcat 216901 acattttttg ttgctcacct gtaagtggtt tttcttttgg aatagctatc gaagcaggaa 216961 gttctttgat aggcttatca atattaatca aattttttgg gtcttctgga gcctccttct 217021 ttttgctaaa tctcttgaac attttttgct tttgtaattt tttttatata aagtggtttt 217081 gtattatttg ttggatggag agaagggaac agttagaaac aaaataagga ttgaaatatt 217141 tttctaacga agaagtggta ttagtctatc tagaactgat atatatacat acatatatat 217201 atataaatat atatatattc agacaatgag cacaatattg tgcatgtaca agagtgggat 217261 gcgcatatag tgcatgaacc tattgcgata aagatctggc aatatataga gagatatatc 217321 gcatgcttgc actcaaatag agtcgggtgg aatgaaaaaa atcataaaaa ttactaagac 217381 ggaagacaaa aagatgacgc gcaacgcgaa aatcgcttat aagcagggat gccgttgctt 217441 ccggttgctt tctttctccg cggaatgact ggacccgtgg gaaatcgcag gggatgtgac 217501 ggccttcgga gttgggttac tgctatttcc gtggctcata gatatacgga cgggtagtag 217561 ggccggttgc ggtcacgtgc ggaaaactat ctccgtcaga tccggcattt cgtacgaaaa 217621 ttccggattt cttcttcttg tggccctttg ttacgggatt tgcggtgaca cttgatattg 217681 aagttacaac atctttgtgg ggataaggat gagaagtagt acggtgatcg ttggtgatcg 217741 ctgttgtatg gggtcgagaa cctgcagcgt ttgtcttcgg agtaggcctg aatagcgcag 217801 gttttttacg attgagaaag attgacggtg attcggatct tctcttcttc accggcgtga 217861 tgggctgcgt aacatctttc ttctctgctg tgacattatc catttgacga tttaccttaa 217921 caggctccgg tttgatggac aatgggcctt tcttggggga agacgattgt ccgcccgctt 217981 ggccaccaaa ggccacacgt tgcgcatgcc tttttgcaat gttgaatccg ccgtctttga 218041 aatgctttag tctggactcg tgatctttca acgatttcat gtataattgc gaatggggtt 218101 cgttgtgcaa ccttgtagtc ttcttggtgt ttctcttttt gaagtaaaca gtgtggtcaa 218161 ccactatggt ttgctttttt tctctttctt gctgcaactt ctgcatttcc agccttaatc 218221 tctctgcgct ttcctcttgt ttcttttcca cttcttgttg gtactttgag tataacattc 218281 tgtatggtat tcggtacttg ttgtttcgga tgtctttgac gactgattga cgcacgcaag 218341 acttcaataa atcctgattc gaatggtaca gttctatatc gttttcctta acgaaatcaa 218401 agtaatattt gcaaataatg tctctcttag agacaaattg ttcgtgtaca ttagtcggga 218461 aatcttgcct taaaaattct aaccatagtt catcatcgtc aaatatcaat agtacgttgc 218521 ttttctcaag ttttaatagt tgtggtattt ttactttctg cagtatcctc tttaataagt 218581 gataggggac attactcaca gattgtatgt ttgaatgatt tctcatcaat gagatttcac 218641 atagtgtttg taaacttttc atatctcgac atcaatcgat ttatacattc actagaacgt 218701 atttccatga acaaaaaccg tttgcatgta agttacatat gtatctaatc gtcataactg 218761 aacaaatccc ttcttcgcaa atattaaata tttgaaattt tctattgtga tctttcttaa 218821 gcccatcgtg gcaaatgccg agaaaaatac gcaattgtac cagctttatt gaaagcgcca 218881 gatatacagt gacaacaccc cgaatatagt tgagaaattt atagtatttc aattattaca 218941 taaaacaaaa ttttggaatt ctgtggttgg ggtaacaaag aataaataga agcaacagaa 219001 atttcaaaac tattatatac ttctatgaca tttttgttta tatttgcact taattttcct 219061 ttttgtctgc ctatatacat acccttataa ccttcttttc ctccttcttc tttctttctt 219121 gtttttaaag cagccttcat tcaccacgca atgccttgat gaccgcgggt cttctcatca 219181 tatgcttcgt ccatttgtaa acttctggaa attcaatttt gatattaatg ccaattctat 219241 ccacgacatt attccatggg acaaaggcca aatctgctat agttaattta tctcctacaa 219301 gccatacggg ataatcaaag aaacgacttt gtgacattgg tgttgtacca gctgagtatg 219361 cagccgcatt ttccgtgtct aattccatca ccagcgcttc tctacgttca gccaaggcca 219421 tctccactac accgtaaact cttctaacct catccgtata tctttctaca gcacttgcta 219481 tcttttgtga atggaagtat ctgaaatgta aagcttgtcc aatcattggc gcatgccctg 219541 acgtttggaa gaacaaccat gcgttgattt gtgattggtc agctaaatca tcggaccaga 219601 gtaatggatt accagtctct ttgtaatatt tatttaccaa atgtaataaa atcgcccctg 219661 attcccaaat agacaagttg tccataccat gatcgattaa agctggaact cttgcattag 219721 ggttcacaga cacaaattcg ggggccctat gttcgccaag attgaaatct aggaagattg 219781 tgttataatg aaatccaagt tcacttagta ctatagcaac tttgaatcca ttaggcgcag 219841 acctgtgaga gaaaagggta tatccctcca gtggttgttc ttgaaaaaat tttgtaattc 219901 tggaatactc cacgtgactc atatccgaaa atgcctgttg ttgttgtcga tgttgttcta 219961 aggtattctt gatattattc tcgttatcat tattttggct accattgcgg ccgctgttat 220021 tgttttgaac attattgtta ttactactgc tattgttatt attattatta tttacacctg 220081 ttgaaaattc aaaatttata ttactttgat cggtggttgt attactgttc ctgtttccta 220141 tgtttacttg acggagcgca ttggagagat tcgacacttg gttgccgttg ttattcatca 220201 tttggtgtac aacttaattt gcagcttaaa acaatatgac taataacaaa aaatgaaaaa 220261 ctaaaaataa agaagttcgt acgggggatc tttattcctc ttcgattcaa ttcagtgcta 220321 taaacaattc caaatgagct gtttgaaaag gaaagatttt tgctattctt ttcaacctcg 220381 agtaaggaag ctttcgtctt tgtatagttg cttttctggc ctagtagaaa ggaaaactac 220441 atgctgaagc cactcttcct caaaaattca atagtggcag ctcatcaatc ctcctattcg 220501 gcgagaattg aaaaaaaaat tccaggctgc gtcacccgga ttaatgttgt tattccagac 220561 aacagtcggt attcattttc cacattgact acagttaaat taaactctac acagctctac 220621 taataatttc tgtttcggcg ttctatggtt tggtgtcact atattctttt ggtcttgact 220681 ttctttcttt tcactacgtt tttcactgcc gcatgccctg ctatcttcac gtggttgaat 220741 agcttatttc gactatcaaa tgattctccg catgtagtgc acacctcgat cgcggaggtt 220801 ggagacatag aggacggtag agtcgacaag gacggagtgc tttttgtgga tttagaattc 220861 tttttaggtt gtttgccctt tttctttttc gctttagtag accaatcttc atcgtcatcc 220921 gtttgtaagc ccttgtctcc tagtgatgcc aaaagatcat ccaactcatt actccgtttg 220981 tctttagtat catcgaacga ttcagattcc tctgtttctg tgtcaacctt tgcttttttt 221041 ttcttttttc ttttcttttt attcttcgta ttcacatgta cattttcatc cgaactgacg 221101 tcttctacct ctatatccat ttctatgttg agattgtcat cttcactttc gtcttcagaa 221161 gacgattctg ccagttttct ttcaatttca gcgagttcag cttgcaatgc ttgcagatca 221221 atatcttctt tttctttaac actttcatct gctgaatcaa atttctcgag atcggagaga 221281 ttatccaacc caagcgttat gttttcctct tccatttctt tccgtatctc ttccatattt 221341 ttcttatgca gtttagtgtt tatgtggttt ttcaattgct tttccgactt aaatgtcttg 221401 ttgcagataa aacactcgta aatcaatact tcaccttcct tatcattctt agaattttcg 221461 aattctccaa aattatcata taccttttcc agttcatccc agttttcttc ttttaccgtt 221521 tgccagcttt gtaaatgaaa tttttcttcg tcattgttgt cgttcccaaa ctttcttctg 221581 ttatttaact catttttcct ctgttgttct tttagtttac gctgttcttc tgcaattttt 221641 gcaccttctt tcattctttt atcgagcttt tttatgaaaa ctacaaacct tttcacggtt 221701 ttgttgtatt catttcgagc ttgttgccta gccttctcat ttcttctatt aacttccctc 221761 ttggttcttc tgtcatagtt tttagagtac atgtactcgt ctttccagct aaaacttttc 221821 aaggtattga acgctgacca agtcttatag aaatgtttca aatattcata atccgttggc 221881 gaatatccaa ataaaggata taaaagttta tccgtcttgt taataaagtt atcgcaggct 221941 ttcaaatagc caatactatt aatatcctgt tcgaatacat catcttgata ctcggaaaat 222001 ttccccagtc gcttaccact taaaatctca tctttagcta acttggcaaa tatttttcct 222061 gcaatttgat atatcccagc agctgagttg tctattttag tataaagagc agagttaaaa 222121 aataagagta attcatcagt tgtgacacct gtgactgtag cgtctacctc ataatcatag 222181 taatcatcag tgcttggtgg agtatcattt aaaatttgtt ccttatgtga gtcataccat 222241 gctctttcct gggggtcaga cagtacttca taagcggctc gaatcacagc aaatttttgt 222301 gtggcttctt caacattatc tgggttttta tctgggtgat attgtagggc ctttttacgg 222361 taagcttttt ttaactcaag atcagaagca tgcgtttcga cccctaaaag ctcatagtag 222421 caggtcttca tccgttattt ttgaagtagt aggatatcac tatactgata ttaactcttg 222481 gctggtcaga cttttactat gtaaaaagag ctactttgcg atgacttcaa atttttttca 222541 cgtatatttt ttttctattc ttaaaacaag aaaaagtgta aacataaaat gttggccgct 222601 taagccctcc aattttacaa caaatgaata ttttatacat acttcctaga atataattta 222661 atcttatacc ttaattttta gttacaatta caacaattta tctattgact ccgttaataa 222721 aaattacttc accatcttct ccaggatatg atcatacaga tggtccagac acctctccaa 222781 atggtgatct atggaatcca tcctgcgcgt tgacataaaa tcatagtatg cttgatccgt 222841 aaatttcttt agattcattt cttgactata tacttgtcta tgcagacgtt gagcaaaatt 222901 ggacagcatg atgttttcat atttcaattt gatagccagc aacggaatct ttcgccttaa 222961 ctttggataa ggaataccaa cagccaaaac aatttctttg acagtatttt gtaaagtcgt 223021 caaatttgct gaatcaattt gttcaaccat aaggaaatta cattcttctg ccgaaatatc 223081 gggccttgac tgtaagatat tttttattgt aatcctttca gaagtatttc cctctaagtt 223141 tccaaatcgc gacctcaaat tatccagttc ctttgataga gtgtttgttt tcttttcagc 223201 atctgctagc attttttctt tatccttcaa tgatgtttcg tatttttctt tgcttttttc 223261 ccatgatcct agtctttcat tcaacctttc cagcttaatt tttatttcct cattacatcc 223321 tttcaaaatt tccttctcat cgattgtcaa cttgtcaaat ttatcacata gtattttgtt 223381 ctgtttggaa agggttttat ttgtaccaat taaagtatta tttttttctc tcatggtctg 223441 gatttcaatt tttttattct ctaactcatt tcggagatcc tcagcttctg cttttgcatt 223501 tttaaatcgc tgagaaatgc ggctcagctc ttcttgctgt gatgcacata aaaacccttt 223561 aatattagga tatttttctt gtaatatgtg atctaatttt gaagaatttt cctccgagtc 223621 atacaaatcg aaaaacaata taccaatcgg tatttcaaac agctcggcct ttcttaagga 223681 gtcagtgaga cttagtaatg cagtgtgttt tgtctgaata gtatcattgg ctttttccaa 223741 catttcttta ttcagcgaaa ggtcctttgt taggttttca atcaatactg tctgttcttc 223801 aatttttttt ttgttatcta aggttttgtc gtttgacttc gtagctgctt cgagctcctt 223861 ttgtaaagag tttgctcttt cctcttgtct tagattatct ctacccaatt caataacttt 223921 tttttgatac cccagtatca cattttctaa cattcgaaaa tcctctttcg ataaggagtt 223981 ttgtagaaaa attttggcac cgttacagtc ttctatcgag atatctggcg atgtatgttc 224041 atcagttggt tgagcagaag cctgttcatt tgccctcgta aaatgcttcg aagagttttc 224101 tctaggagta gagtgtatga aattgggtac atccttttta tgaacatcag tacctatggg 224161 agacttatct ttttcgtttt ttggtcgttc ttgtaatcct ggagattcct gataactagt 224221 atttctagca taattcattt gatccataga tggtgatttg ttctcttcat atgagtctct 224281 agcattggaa aagttgcaat tgatgacatc ttcagggtta acgaataaag gtaagatgga 224341 ttttccgaca tgattttcat ttagccagtt ttgtgggatt ggctctccgt ctttaatttc 224401 cccattctct gatacaggag aatccaaacg ctcatgaaat ggaaaattca ttaaatcgaa 224461 atcagtcatg atgtacaaaa gacctgtcac tatttactag tgattatttt ttgtatgtgt 224521 agatttcttc ccgaggaacg ttaacgttat tagttgtttt attactataa acgttccaca 224581 aaaaattgcc taacgcctca cgtcgcgcaa cgcgaatttt cacaagaaga tgttatttac 224641 agttacgata attgaattgg atatgtaacg agaagttgta cctaaaactc cgtatgtgta 224701 tattaccata gatttttcat ggtctagtct agaaaataaa aaaatatgta tatacgcaat 224761 tgttaagaaa atgaggatta aaagcttgga aaatattaac tttcactgtg tcttaaaccc 224821 gatctattct ttttaatttt ggcaaaaatt ggttcactta tacctttatt gccttgaata 224881 ccaaggccct ctccactttt ccacccaagc ttttccaaca ttcttctacc gatattttcg 224941 tttccaatct ctggagcgtt ttgaccaaca atctcacctt ctttaacatg aaatttccct 225001 ctgattgttt tagttctttc gaaagcagct tgttcctccc tcggtcttct tatatctatt 225061 ctcatgaata ctggcctctg cctcatcaat tggtcaatga gactataatt cggagaagac 225121 catttcgttt tctttatttt ttctacaaca accgacgtat gatttgcttt cccaattttt 225181 gaactcttca tattataatg cttcgcaatt ttcattacgg tcttgtttcc atgaggatct 225241 aatggaggga aagtcagtct atcattgttc ctagacaaaa aggactcaaa ttcatcttta 225301 atattttgaa tatggagtcc atatgggtat ttcttgagca tatcgttcga atttctattc 225361 tcctgatcaa tgaaatcttc tttggctttt cttttctttg ctttggtttc tatgcgttta 225421 ctaaacttac tttgtaacgt ctccaacgtt tctgtatcca gcgctaaggc gtcatcgatg 225481 agtagcttct tcttcttacc tttaccctta gtttccaagg acttggtttc aaatgttttg 225541 aatctttctg tatcatgttt caatgtgtat gcaattaggt cgtccagacc ctcttcaatg 225601 tcgctatgca caaccgagga ggccatatct tcatcatctt catagctgtc gccttcatag 225661 ctgtcacctt catcactcga atcagaaatc ggaatatctg agtaggttgg ctcagctggt 225721 tcaatttttg gtataagaga atttttaata aaattcaaat atgcaggtaa tctatcttca 225781 ggaagaccta actcgtctac aacgaagtct gtgagtaagt cctggtcaat ccaatgaaag 225841 tcgtaatctc ccagtaatct gtaacaccgt agataatatg aattgtctac tccgcccatt 225901 cttatattgg agaccactat gtcattagta tttatgacaa aatcttcttc tttgaatcca 225961 aattctaact cttcgctagc aggagatggc agattatcat tattgccttc gaatgttttg 226021 gtaccattta ttgaaagaca ttttatatct tctgtcaact gcggactagg gcttggtaaa 226081 agattgttgt cagctcggga attgtgacgt tggccaacat aattaaaccc ttgatcaacc 226141 tcagaacttg ctgaggattc gtataaaggt tcactattat tctctgtttc tatttcgtag 226201 tctagttcat cattgtccga gtcgctagta tgcataccat gtaatacgtt ggaaatgtaa 226261 ccagcaaatg gatgatatgt cttattaccc ttatttggaa cgtcaacact aatttccttg 226321 ctttcgttac cttcggaaac gctaagttca acctttccaa ttgttaagat aggatcgaac 226381 tctatcgcaa cttctcttgg ccttgcgatt tcctcgatac atactctttt tattttggtt 226441 agatccggcg attgctgagc ctcttcatct acaaaaaaca ggtcaccatc ttcaactttg 226501 ctttcattcg aagacagcga gtggtccgtc gagggtgaat tctgactatc atcatcctcg 226561 ttttcactgt cttcattgtt aatatattca acatcagaag tcatctttcc tggttcttca 226621 aaaacgtctg cttccctttc gacaatttct tcactgttct ttgtttcgtt ctttgctctc 226681 agtttttgaa tcatattgtg ggatggatcg taaacttcct tagcttttac aaattgcata 226741 ggtcttttgc ggaatgctgc ccttcctgct tgtaggtcag ttgaagaatc atatcgatta 226801 cctggtctta aaccacccat tttcatagaa cggctcttgg catcgcgacc aaaataatag 226861 tcttctatag tttttggtga tatgaatgct cttcctgggt tgaagtcggc gcctacatca 226921 tcaagatcac cttctcctag tggtatagaa gagttatgcc aactgttagt gggagtaggt 226981 tttttcttta tctttctgcc ttgtatgcct ttagcattcc ccctgccagc tttcttggaa 227041 ttgctaccac gtgcatgcct acgtctgctt ccttgataat gactatgcct ttttgccatt 227101 ttttttgacg gttacaacaa tttatgctta tatttgactc tgcgattaaa tcacttcttc 227161 cttctagaaa ctctgcgcag gcctaattgt tgttgttttg ttcagatctt atttaattgt 227221 aaaatgtcaa atttcacttt tattctttag gcggtgaccg ttgcagctgc caacaatagc 227281 gcctcaaagg aaaaaagtaa aaatatacac acaataacgt tagtagatga agaatggacg 227341 acttcttatc acgtatagga gtgatataca tgcagaggtg gctacaactg tggaaaatgg 227401 atttggtaca aaaagtgtct catggcgttt ttgaaggctc gtccgaagaa ccggctgctc 227461 ttatgaatca tgattatata gtattagggg aagtatatcc tgagcgagac gaagaatctg 227521 gcgctgaaca atgtgaacaa gactgtcgat atcgcggtga agcggttagt gacgggtttt 227581 taagctctct ttttggtagg gaaatttctt cttacacaaa ggaatttctt ttggatgtac 227641 aatcaagggt caactttaca tatcggacaa gatttgttcc tatagcaagg gcgccagatg 227701 ggccttcacc tttaagtcta aatttattag tacgtacaaa tccgatcagt acaatagagg 227761 actatatagc aaatcctgat tgctttaaca ctgatattgg gtgggggtgt atgataagga 227821 caggacaaag tttgttgggg aatgccttac aaatccttca tttgggcaga gatttcaggg 227881 taaatggtaa cgaaagtctg gaaagagaat caaaatttgt aaattggttt aatgacacgc 227941 ctgaggctcc attttcgtta cataactttg tttctgcagg tacagaactc tctgataaaa 228001 gaccaggtga atggtttggt cccgcagcta cggcaaggag tatacaatct ttaatatatg 228061 gcttccccga atgtggcatc gatgattgta tagtatctgt ttcatccggc gatatctatg 228121 aaaatgaagt tgaaaaagta tttgctgaga atccaaatag tagaatattg ttcttgttgg 228181 gcgtgaagct cgggattaat gcggtaaatg agagctatag agaaagtata tgtggtatct 228241 taagttcaac acagtcagta ggcattgccg gcggtaggcc gtcttcatcg ttgtattttt 228301 ttggttatca aggaaatgaa tttttacatt tcgatcctca tattcctcaa ccggcagtag 228361 aagattcatt tgtagagtcg tgccatacca gtaaatttgg taaattgcaa ctatcggaaa 228421 tggatccctc gatgctcatt ggtattttga ttaagggcga aaaagactgg caacaatgga 228481 agctagaagt tgcagaatct gctattatca atgttcttgc taagagaatg gatgactttg 228541 atgtgagttg tagtatggat gacgtggaaa gtgtaagttc taactcaatg aagaaagatg 228601 caagcaataa tgaaaatctc ggagtactag agggagacta cgtagatatt ggtgcaatat 228661 tcccacacac aacaaataca gaagatgtag acgaatatga ttgttttcaa gatattcatt 228721 gcaagaaaca gaagattgtt gttatgggaa acacacacac tgttaatgcg aatttaacag 228781 attatgaagt agaaggcgtc cttgtagaga aggaaacggt aggtattcac agtcctattg 228841 atgaaaaatg ctagtgtaag gaattcacta gttcataagc atatatactt gttttaatat 228901 attccctaaa actgaggtat ccagttcttt tgttcttatt cgtttgatca tcctttacgt 228961 atttttcgtc tgcggcagtg gaaagaactt aaaaaacgaa agataataaa gaaaaaggcc 229021 agtcggcacg aattaaagac cacctgtaag aagattaaga caacggtggt ataaactagt 229081 gtcgaagtcc aaaatgccta gtcatcgcaa ttcaaacttg aagttttgca cagtttgtgc 229141 atcaaacaac aatcgttcaa tggaatcgca taaagtcctg caagaagcag gctataatgt 229201 tagctcttac ggaacaggtt cagctgtgag actgcctggt ctatcgatag ataagcctaa 229261 tgtgtactca tttggtacac cctataatga tatatataat gatcttttat cacaatcagc 229321 agaccgttac aagtcgaacg gtttattgca aatgctggat cgtaatagaa gactcaaaaa 229381 agcacctgaa aaatggcaag aaagtacaaa agtcttcgac ttcgttttca cttgtgaaga 229441 gagatgtttt gatgccgttt gtgaagattt gatgaataga ggtgggaaat taaacaaaat 229501 agtgcatgta attaatgttg acattaaaga tgatgatgaa aatgctaaaa ttggtagcaa 229561 agctatattg gaattagctg atatgctcaa tgataaaata gaacaatgtg aaaaagatga 229621 cattcccttt gaagattgta taatggacat tttaactgag tggcaaagct cacattctca 229681 actaccgtca ttatacgctc cttcatatta ctaaacaaaa cggtcaatta ctgtagaaaa 229741 gcataagcat taagcggccc tcatgaatcc tacattatcc gtgaaatttc aatactttca 229801 caagtcttcg atagcttcct agttatattc attatataat attacgtttc ttgttgcggc 229861 tctcttaagc acattatttg cttgttgtcc acatagctat ttttttatca agaagcttga 229921 tatacaacac actgtatttt tagtaagctg gacaatgtct tgtctcaatg tagcgtataa 229981 caggtttcat tccaaaacac atcaccagat ataggactga aatgaagaaa atagaagcat 230041 gaaactttaa aagtttcagt actttaagaa agaaataaat agaaaaatgt tccatttatt 230101 tctgaaaata aatcaaaaat tataagatcc acccgttcct accaagacct tccaaaattt 230161 ttcccataac gggaacgagc aaagttgaga ctgctcaaaa gagcacatct tcaaactaca 230221 atcccgacca aataatctca acagccatac cttcatcata aacttaagtt cattcgaatc 230281 tgccgtcaaa aactaaaatg gcacgctaga gaaaagtagt caaaaagaat gcctctacaa 230341 agctctcttt tgaaaggccc cagctcccct aacaccaatt tgaatttggt gtcaaacttc 230401 tccaggcaga agaaacaaag ggccccaaaa atcagtttaa cccaaaaatc cccaaaggaa 230461 tcaagggatt aaccaatgat tgaaacaagg gaatggaaac gtcagcaaac acgccttccg 230521 cgccgtatgt gtgtgtgacc aaggagtttg catcaatgac ttcaatgaac aattatagtt 230581 caatgataaa tgcttaacgt ccttctacta ttggaagcgc atgtttgatc agtaggactt 230641 cttgatctcc tctgatatct taaggtaagt atgaggattt taaaaaaatt caagaaaaaa 230701 ctatatttta acgctaaaag tatgtttgta aaatagttct attaaatgga acttcttctc 230761 tctatttata cgtcttgcca atggaaaact cgtcgcctta gaaaaaaaaa aggtgcaaag 230821 acgggtaata atttcattga cattttcaag agctagggaa tgaatcaatg agccctatga 230881 tggcagcgta gatcaccgta tttaaattaa catataataa gatttgttgc cactttcaat 230941 ctctaaatgt gtacgtatag agttccagga agcaaaaaga ccattattgc gcgatatgat 231001 tgctatttgc cctctgtata catagcttta taggatatcg gtcgtacata taattcagtt 231061 cagttcatta tacggatatt ttcgaccact cccccaacct ataagtgttg gtacctacat 231121 ttctgatcag tacataccta gttggttgcc ggatggccgc atgatgatct ataaatccga 231181 ttcccatacc atttccacaa tttaagtggt aggtgccgct ggtaataaaa ccaatcaaat 231241 catgtacctc tggaagtgga attttcaaat catgatcttt tcttccgttt gggcggtaaa 231301 ccccttttgc caattgtagc caatgctcta agtccttttc tggaacttga tatattcttg 231361 cattgtcctt tgggtgacct cgttcgagta gtgtgcaaga tacagcaatg atacaacgtg 231421 ggaagaatgt aagggagaat gaagaactat tgacgctaat gctatcagga gtgcgaaatt 231481 gacatttccg atttttacac aatgcaactg gtatgttctc ttcaatcgac aacgacatag 231541 ccttggtctt ggcttcataa tctttgcaaa actccaaaac atcatttaca cagttgatgt 231601 ctcttacacc ctgagcgtta aattgcccgg tcttcttact gtccatcagt tctaaggttt 231661 tatcattccg ctgtaaataa tcaattccat ttctcagtat ttgtaaaaat ctccagtctg 231721 aactgaaaaa atcgccgatt tctccgctat atgccggtaa tttagtgtta tggatgtctt 231781 tgatcttctc gaaattaatc ctttttccca ttggcttcct atcccacttc gtcttggagg 231841 cctccttttt ataaaatgag ttttctatat aacccaattg agtgaatgga taatcatccg 231901 gaaaatataa ttgcttattc tcgtactgaa tttgctggaa ttgcctgagg ccaatgtgat 231961 acatccttgg tatccggttc agtagatgcc ataacggtag cagccagaac catggtaaca 232021 caacaatcca atccctggtc ttgagccttc ttattatgac taatggaata gaaggatcgt 232081 cactttcttt gaacgggact gtagttttat tgatgctgtt cggtgtggca gttagcaatt 232141 tgtaacgtct cgcagaaatt tcttttaatg tgttttggtt gttgtatgat tgagtacgtg 232201 attcagggtc acataattcg ttaaaaacgg cgtttatttc gtcttgagga tagttttcat 232261 gcagtgataa aatgtcgtca gaattaacag tcttcctctg tgaatcattt aatttctttg 232321 gagcagctag atgacgcgga tctatggctt caaatgcaaa cgtacacctc tgtggtaggg 232381 cattatgatc ggtaatcatt gaaaccattt taaattgttc aaacgattta gagtactctg 232441 tgctccttaa acacgatgct aatgactcta gagctttagc tcccttcaat gtcacgcttg 232501 ctaatgaata tcgacaatct tgtactgtta gtttttcctt atgttgcaaa agaatgttaa 232561 aaacctgagt ataaattgaa gggtgtaacc ttataattgc agtatccttt tgtacccaaa 232621 atacgtcgca tggacccagt ggcttagtag aatcctcacc gttttcttca ttgaaactat 232681 aaattaaccc ttggaataaa acctggcctt cgcgatattt ccttaagttt gctctttcag 232741 ctgttaactt tcctataatg gattttaaaa agtccccctc actgtcattg cttttgtctt 232801 ttacaattat tgtaccaata taacttgaat ccatgcataa ggccccatcg gagctgcagg 232861 tatcaccgcc caacctatgc gtcaatttaa agcatttttg agtaggtgcc cataccattt 232921 gatatcccca tcttttcatc atgtgcgacc ttttagcatt ccaaatgtgg gtgggtagcc 232981 aagcaaagtg cttctgtctc ttcgtatatt tgaccctgcc cttgggaata ggtgctaatt 233041 cattgacacc agtgcaatca tagctcccca tacgattatt aagtaacttt atatttggat 233101 ttgctgttga tgattcttta atcattcgct ttaatgtctt gattttctgc cttacgtggc 233161 agttagatga tgtaacctct ggtggcatgc tgagtttcat agaagtagat ttgctagcca 233221 atcgtagcag ctttatggac attctagctt tataaagttg ctttgcattt aggccatgag 233281 cttttctgga agaggctgaa gaccccttca acacatcctg ctgatcactt ttacgcattt 233341 ccctcaaagc tctattgcgc attctttttg gaattctacg aacattatgc gaagccgttc 233401 tacgacgcaa ttttcgaggc aatgcctgaa atattctcgt tgagctggct gctttggaat 233461 tatgcatggc caattgcaac tgcttaacct cgaattgtcg agaactaatg aattggtcca 233521 cgtttagctt acttcccgat tcactcagat cactcggtgt cccagttttt gttgatgaag 233581 cggccacggc ctctgctcta attgatctag catttcttat gcgatttcgc ttcagtaatt 233641 gattcttatt aagaactttc tttccaccat ttcctctaga caaactcccg ctcatttgta 233701 attataatga ggtcaattct cacctttctt gccaaatgtt caagtggcag gctgctcaat 233761 aagtatcccc gttcttcaaa gacatgccac cgttccgaga atctcatcga attcagatct 233821 gctttcttct aatgcgaatt tcactgaaaa gttttcccac agtgttaccc tcttacccgg 233881 gtgcaatgtc acgtgcacat cacatatgaa aaaatgacca gcaaagaagt caatctacct 233941 tccttatggc cggtagagtc aatagtaatt tactttgcaa ccaattaata aatctgtaaa 234001 cttaaaggaa tcagcaatta ccgcaacccc agagaatcgg atggtgagat tagtcccatt 234061 caattcgctc tcgtgaccaa atcgtcggga aaacatgtcc cacttacctg ttcctgtgaa 234121 tccagatacg gaaaaaaatt gtatttaaat aatctcgatt ttacatttac tgatcgcgat 234181 ccttttcatt gagtcacaga ttaacaaagt aaataataat aagtaaacat tatttctaaa 234241 aaagtaattt ctttttctta ctagtctttt cttttttgac tttctcttta tttcttaact 234301 tgccttataa aagaaacgat tgtagaagct tacctcgacc gagtaaatat taagcttttc 234361 gttggataag gtaggggaaa tcgtaacatt actaaattta aagcatatca gaatggttaa 234421 cgttgtattg ggctcccaat ggggtgatga gggtaaaggt aaactagttg atttactggt 234481 tggtaaatat gatattgtag cccgttgcgc cggtggtaac aatgccgggc ataccattgt 234541 tgtagacggt gttaagtatg atttccatat gttaccatct ggtttagtca acccaaactg 234601 ccaaaacctt ttgggtaatg gtgttgttat tcatgttcca tcttttttca aagagttgga 234661 aaccttggaa gctaaaggtt tgaagaacgc aaggagtaga ttatttgttt cttccagagc 234721 acatttagtc tttgactttc atcaggtgac tgacaagcta agagaattgg agttatcagg 234781 tcgttctaaa gatggtaaaa atatcggtac taccggtaaa ggtattggtc caacttattc 234841 cacaaaggct tctagatctg gtttgagagt tcatcatttg gtgaatgatc aacccggtgc 234901 ctgggaggaa tttgttgcta gatataagag attattggaa acgagaagac aaagatacgg 234961 tgatttcgaa tacgactttg aagccaagct tgctgaatac aagaagttaa gagagcaact 235021 aaagccattc gtcgtcgatt ctgtcgtttt catgcacaat gctattgaag caaagaaaaa 235081 gatattggtt gagggtgcta atgctttgat gttggatatt gattttggta cttatccata 235141 tgtgacttct tccaatactg gtattggtgg tgtcctcacc ggtttaggta ttcctccacg 235201 tactattgat gaaatttatg gtgttgttaa agcctacaca actagagttg gtgaaggtcc 235261 tttcccaacg gaacaattga acgaaaatgg agaaaaactg cagaccattg gtgctgaatt 235321 tggtgtcact actggtcgta agcgtcgttg cggttggtta gacttggtag tcttgaaata 235381 ctcaactttg atcaatggat acacgagttt gaacattacc aagttagacg tcctcgatac 235441 tttcaaagaa atcccagtgg gtatttcata ttctattcaa ggtaagaagc tagatttgtt 235501 ccctgaagac ttgaatattc ttggtaaagt tgaagttgaa tacaaagttt tgccaggttg 235561 ggatcaagat attaccaaaa ttacaaagta tgaagatttg ccggaaaacg caaagaagta 235621 cttaaaatat attgaagatt ttgttggcgt tcctgttgaa tgggttggta ccggccccgc 235681 aagagaaagc atgttgcata aagaaattaa atagggcgtt ggacatccat gacaaacttc 235741 aatttaattt cttttcacag ttttatagtt ttatatatac gaaatgtaac taatcatgac 235801 attttttaaa agttttcaat gaaaaaatga aagagtaatg aacaaacata ttttttttat 235861 aaaatgcata aaaacatata gatatatata tatttacgtg gaaaaatgtt aaaactattg 235921 ataagaaaaa acgctcaaaa caagtagtaa gcaggctttt tttttttttg ctgcttgttt 235981 tagagaacct gtatatcaat tagtagtctc agttggtttt tcaaacaaac agtaatcaat 236041 gtaacgaaca ccgtacactt gattccattg ttttggtaaa actatttgca tgattcggtt 236101 gattggctcc ggtacgtaaa atgctctacc caaaatctta gaattttcac cgtcgatgaa 236161 tgcagcacat gccagcttat tccagttatc catcagatgt agagggttga aaacgtcttt 236221 tgttaaattt attggggcga cgatgtcaat aaaataatca catctagtga tcggccactc 236281 tttaccggta tcatatatat tcttgttatt cattccctta ggtaaagttc taatcttttt 236341 gaaaatagaa ccactctctg gaaaatcacc tggaagaaga ccatcaaatc cagatttaac 236401 aaattttagc ctatgattat ctggcagcag gaaagaactt gggaagtgat accattcacg 236461 tcccgtacat acattcacta ccggtgcctt cacaccacct tgatttagtg aagaaaattg 236521 ctcgtagacg gctataggag ctgtgtaatt gttcaccaaa gccactatcc gtgacattgc 236581 ctggcctgca acaattaata aaactgacaa ctttatacct tttttaagaa tcggctttct 236641 attgaataga ttcaacactt tgtaaaaggc gatacttgca ctcaaagtta ttaacccgta 236701 aattggatag agaaatcttt cctctttgtg aggttgttga gtgaaaacgg caatccatgt 236761 gaataatgat gcccataatg gccataatct caaatggaaa attcccaaaa tagctaaaac 236821 tagcacaggc agtgggaaat tcagtaacaa atttagtgga tagtagtacc atggctcaac 236881 cccgaaaata tttgggccag attcctcact tgcattaatg acattgtaaa ataagatgtt 236941 ccatgataca ggagcaagct tcccgtaaaa tatactgtca gtgacaatca cagcaaatgc 237001 agtcaatgaa aatatcaaac agcagtcgaa tgcggttctg atggtagaaa taattctatg 237061 gttgaaaagg taatgtaaac ataatggcaa gcttaaaatt aaaacaaatg gccagcctag 237121 tatactagcc aggaaattgt acgctaaact tttcgtaaag ttagaagtag acccagtgga 237181 cagatagcgt agagagtgtc tggtggcacc tacatacaac aacatggcaa cggcagaagg 237241 caataattcc acagatgcat ggaaccagcc cggattaaac aattggaaaa taatccaaat 237301 atttgcgatt tgcaatgcca agctgcctgc aatttcacga tgtagtttaa attccatgat 237361 aaaactaaaa aagcctaagc atgctcttgt gatgaaaaag ttccaatgac tttctaggtc 237421 agtaaatttg tttactggat aaagaataca gtaaaaaggt aataagaaag cccatgatct 237481 aatagaatac tcgggtgaat attcccaggt ttgtttacca aatccacgta ccaataaatt 237541 taatggttcc caataattaa aagtttcatc gcaatctgaa attaacgaga atgtcggctg 237601 aatatatact cttgttaaaa ataacaacag taataaacta atggttaccg ccttgcaatt 237661 catcgttccc ttataattgt gcttcagggt gaaaaaagag ccaattcgat acagctaaag 237721 ttttgaaatc tcgttgagta gccgtaatgg tacaataaaa acgaaaaagt attctctatt 237781 gtgtcaaaaa cacccctgta tatccagttg tccctttttc aagcttgtat tgacagttct 237841 gaatatcgca gaacggttct catcaaaatt caatattgcg taacggactt attgttgcat 237901 tttcaagtaa ataagccggg tcaggatgcc cgccgtagat agtaaaaagt aggtataaca 237961 tgcgcaagag caaaacggat ttgacaacat atccaagtga taagtggtcg tttagataca 238021 tcatatacta taacggtttg atattgagag cccagttaaa attaacatct gttttttgtt 238081 ttttaattga cattcaatca tcggttgctt tccttgtgaa actgtacgcg ttgtcttaaa 238141 cgaaacgtgt tttaaggtag gtcatcgaca ggtaaaaaat agcttattag cagaagaacg 238201 ctagcggtaa gatctgaaac aggatcgcac agtctcaatg agtaacaaga ggacatctgt 238261 agaacagctc atatcatgcc caatttgctc tagaaaagtc tttttttcct taatcaactc 238321 tcatcttgac atatgtggca aggaaaagtc aaagccttcg agtaggccac aaacggtgtc 238381 aagtcttttg gcaggcccaa aaaagaggaa acaagctaac tcagagaaat tcattgatct 238441 tgaaaataag gaccatgaaa ttaagccagg tcttaagagc gagagtgatg atattgagat 238501 tgttgaaaat gaaagcaaaa gatttaaggc agcaccatcc acggattttg cgaaatcaat 238561 agtggagcct gcttcgagca gagatcaact tcacaacgat tacgaaagca gatggttgca 238621 gaaaataagc catttgccac ttagtgaaaa attgaggcca aaagaattaa gagattatgt 238681 aggtcagcag cacattctct ctcaagataa tggtacattg ttcaaataca taaaacaagg 238741 gactatacca tctatgatac tctggggccc tccaggtgta ggaaagactt cactagctag 238801 actattaacg aaaactgcga caaccagtag taatgaatca aatgttggtt ccaggtactt 238861 catgatcgaa acaagtgcga caaaggcaaa tacgcaagaa ttgagaggta tatttgaaaa 238921 atcaaaaaag gaatatcaat tgaccaaaag aagaactgta ctttttattg atgaaattca 238981 cagattcaat aaagttcaac aggatttgtt attgccacac gtagaaaacg gtgacattat 239041 tttgattggt gcaacgacag aaaatccaag ttttcagctg aacaatgctc tcattagcag 239101 atgtctgatt tttgtcctag aaaagctgaa tgtcaacgaa ctgtgtattg ttttatcaag 239161 aggaattgca ttattgaata aatgcaggaa acaagtatgg aatattgaaa atcctttgaa 239221 attgtctaga agcatactgg agtacgtggt agatctgtcg gtgggtgata caaggagggc 239281 gttaaatatg ttggaaatga tcgaagtttc aacaagagag cgcaaggccg acgaggaaga 239341 attatctatc gatgatgtac gagacataat taagaacaac agcagcaacg ggttgaatac 239401 atactatgac ccaaagggag ataaccatta tgatacaatc tctgcgtttc ataaatccat 239461 tagaggtggg gacgaaaacg cctcactgta ctatttagca agaatgttgc agggaggaga 239521 ggacccattg tatgttgccc gaagaatgat tcgaatagct tctgaagata tcggattacg 239581 ggatagttca ttattgccct tggctgtcgc ggcacatgac gcagtaatga aagttggttt 239641 gccagaggca gaccttgcac tggcgcaatg ttgtgttgct ttggctaggg caccaaagtc 239701 agtagaacta tatagagctt ggaagaaatt aagggcaatg atgagcgaga acatgtacag 239761 tttagcaagc agtgagatac cgatgcatat cagaaatgcg ccaaccaaat tgatggagga 239821 gctgggttat cataaaggct acaagtacaa tcccgattat attgaaggaa aagtccaaca 239881 agactacttt cccaaagaag tgctcgagaa atgtccaaat aaaactgact taaagttcct 239941 ggacggcaaa catttaggag acaaagaaga tcctgacttg agacagtcat atcagggtta 240001 gtcaagggtc ttccatactt ctctcaatgc cgcgtctaca attcatattt ttttctctgt 240061 tggccaatgc cgcttgtttt tttacgcttg aggcgcattg cattgctggc acgtttttgt 240121 gcagcatgaa cgatataaac tataatttta gataatcaag gatccacctt tttttttcat 240181 gctagaaaag tctcgcgggc ccatctgaga tatattagaa catatacgca tcctataaga 240241 agagcacatt attcttgaat tagttcttcc ttttcctcga ccttccagct tgtaaaatga 240301 gccaggcttg aggagcatag atacgcaaaa atggaagata agcggaaaag acgagccgct 240361 acacttagta cagcattgat attatttgtg gcatgctgcg tttatacact atatatattc 240421 aagtttgata accctcggtt gtctccacca gtttccttat tgcctacaat tagcaccttg 240481 aagaaaattg agcatgtaac agatttaaat aaggagtacg tttttgttgg tgacgttcat 240541 ggtaactatg atgagttcat agaactcatt gatgacaaga ttggaggact aggagaaaat 240601 ataacaatga tattgctggg tgactttatt cacaagggcc cggactcaga caaggtcgtg 240661 tcgtatattc taaatcacaa ggatcaagtc aagtgcgttt tgggcaatca tgaaatattg 240721 gtcatgatgg cctatttaaa cccagacttc tcgaaatggg taagacgccc caaattaatg 240781 acacctttaa ctttcagtac ggagactaat ttcataccac aagacatctc taaaatcagc 240841 aacgcacatg gacggttagc tcgcgaactt gggttttcca aattaagtca gctagcggaa 240901 cattgttcta tggccataga actagatctg gatattaccg gtgatatact ctttggtgca 240961 catgcaggga tggttccggg agacttcatg aagcccaacc aaattccggg cgtgagctct 241021 ctgtcaaaca tgaagtacgt tgataagaag aactggtcaa aaacatcacg tgaaaaggaa 241081 aacaagaatt atgtgagatg gtacacactg tgggacaaat acggagacca ctttagtaac 241141 gccaaagtat tttacgggca cgatgcatcc atgggactaa acctacggag acagaccaaa 241201 ggtttggaca cagcatgtat aaagaacaat ctgctttcat ctatgaaagt gaagtacgat 241261 attaagaagg ggcaatatga ctatgaatta attcaagtac aatgctctta aaacaaaaag 241321 tactacttaa aagcgcaaca gattttatat aatgtactat atgaaaaaga tatgaatatt 241381 attatgtaac tcataatact gaatcttaaa tttcaatgaa actttcgctg gagctacaag 241441 tattcttgcc caatggccgc tacccgcctc ttcttcgttg ttgaagtttt aaaatttagc 241501 gagaaaagaa aacaaaaccg aaaacagaca accgcaatca tttcttcaac acccaacatc 241561 cagcacctaa acaccatcaa tacacgtttt aaacaaaaca aacccatagc ccaaaaggta 241621 gtaaacacaa accgttgtat acgcaaccgc cctacataag acactatttg cgtacagatt 241681 atctcaatat gtctagtcca gatgattttg aaactgcacc agcagaatat gttgatgcat 241741 tggatccgag tatggtcgtt gttgacagtg gttctgctgc agtcacagcg ccatcggatt 241801 cagccgctga ggtaaaagct aatcaaaacg aagaaaacac tggtgctact gctgctgaaa 241861 ctagtgagaa agtggatcag acggaggtcg aaaagaaaga tgatgatgat accactgaag 241921 tcggtgtaac aactaccacg ccttccattg ctgatactgc tgctaccgct aacattgctt 241981 cgacatcagg tgcatctgtt actgaaccta ctactgatga caccgctgct gatgagaaaa 242041 aggaacaagt aagtggtcct cctctgtcaa atatgaaatt ctatcttaat cgcgacgcgg 242101 atgcgcatga ctctttaaat gatattgatc aattagcgcg tctgattaga gcaaacggtg 242161 gtgaagtgct agactccaag ccaagagaat caaaagagaa tgttttcatc gtgtcaccct 242221 ataatcatac caatttacca acggtaactc cgacttatat taaggcatgt tgtcaaagca 242281 actcgctact gaacatggaa aattatttag taccatacga taactttaga gaagttgtcg 242341 atagtaggtt gcaggaggaa tcgcattcta atggtgtaga taatagcaat agcaatagcg 242401 ataacaagga ttctatcagg cccaaaacag aaataatctc tacgaatact aatggcgcta 242461 cggaagactc aaccagcgaa aaagttatgg tagacgctga acaacaagct agattacaag 242521 agcaagctca gctccttcgt caacatgtaa gcagcaccgc atcaatcaca agcggagggc 242581 acaatgactt ggtccagatc gaacaacctc aaaaagatac ctccaataat aataatagca 242641 acgtcaacga cgaagacaat gatcttttga cacaggacaa caaccctcaa acagcagatg 242701 aggggaatgc atcttttcaa gcacaaaggt ccatgatttc gagaggcgct ttgccctccc 242761 acaataaagc ttcttttaca gatgaggaag atgagtttat tttggatgtt gtgagaaaaa 242821 atccaaccag gcgtacaaca catactcttt acgatgaaat atcccattat gtgcctaacc 242881 acacgggtaa ttctattagg caccgattta gagtctatct ttccaaaaga ctagagtacg 242941 tttatgaggt tgacaagttt ggtaaattgg ttagagacga cgatggaaat ctgataaaga 243001 ctaaagtttt gccaccatca attaaaagga aattttcagc agatgaagat tacactttgg 243061 caatcgcggt caagaagcag ttttatcgtg atttgtttca aatcgaccct gatactggaa 243121 gatcacttat cacagatgag gatacaccca ctgctatagc gaggaggaat atgacaatgg 243181 atccaaatca tgtgccaggg agtgaaccca actttgcagc ttacagaacc caaagccgta 243241 ggggaccgat tgcacgagaa tttttcaagc attttgccga agagcatgca gcacatactg 243301 agaatgcttg gagagatagg tttaggaagt ttcttctcgc ttacggcatt gatgattata 243361 ttagttatta tgaagctgaa aaagctcaga atagagagcc ggaaccgatg aagaacctca 243421 ccaatagacc caagaggcct ggcgttccca ctcctggcaa ttataactct gccgccaaga 243481 gggcaagaaa ttatagttct caaagaaatg ttcagcctac tgccaatgca gcgtccgcta 243541 atgctgctgc cgctgctgct gccgctgctt ccaactctta cgctatacca gaaaacgaat 243601 tactggacga agataccatg aatttcattt ccagtttaaa gaatgatcta tccaatattt 243661 caaatagttt gccctttgag tatccacacg agattgcgga agctataaga agcgattttt 243721 cgaatgaaga tatatatgat aatattgatc ctgataccat aagctttcca ccaaaaattg 243781 caacaacaga tcttttcctg ccattgttct ttcattttgg cagtacgaga caatttatgg 243841 ataaacttca tgaagttatt tcaggagatt atgagccatc acaggctgaa aaactggtac 243901 aggatctttg cgatgaaact ggtatacgta aaaatttcag tacgagcata ttgacgtgtt 243961 tatccgggga tctgatggtc tttcctcgct atttcttgaa catgtttaag gacaatgtta 244021 atcctcctcc caacgttcct ggtatttgga cacatgatga cgacgaatcg ctaaaaagca 244081 atgatcaaga acaaataagg aaactggtta aaaagcatgg aactggtaga atggaaatga 244141 ggaaaagatt ttttgagaag gacctgttat gagtaattga attaagtaac atcattgttt 244201 aacttatttt actcctttat ttcactgatt cacgttttct actttgtttt tcagttcaat 244261 gtataattta tgtaaacttt tacgtatttt aattttcaaa attcttacaa tgattaaggc 244321 ggaacagttt tatagaatcc cattagcaaa aaagagagaa gaaaaggagg aaagtataac 244381 gcagaacgaa gattctcatt tttaacgtgt cttttcttca aggataaaac gcctaactag 244441 caaataactg gcgattagca gactacaatg gacagtgaag caagtgacat tgaggcagag 244501 ttatccgaca gcgtctcagc tggtggggaa gaatacattg acgatgatga ttatacggaa 244561 gatattgacg atcagatagt cacagccaaa tcatctagaa gaacagcacg taggagtgta 244621 cctaagggtg taagaacctc aaaacgcatt agagataaag aactttctgt ggaggttgat 244681 gaagattatg atgaggagga agatgtattg agcccttcta agaagcgcca tctacacacc 244741 agatcaatgg acaaaaggca agttgccgca acagcttctg aaaaatctga tattggtgat 244801 agtaaaggta atgatggcga aatagaagac ggtatattgg aagaagaaga gagcttagag 244861 aaggaactga atagaggtgg aggaaaggag gtagagaaaa gtgaagaatc ttactacgcc 244921 caaaacgatg ttggacagaa gggggaggaa gaacaagacg gggaatctgg aggctatgaa 244981 gataatgaac ccagtataag taaagagtca gacgaattgg tctctgtggt aaacggtaac 245041 ggtaacgaag aggatgatga agtggaggca acaaaagaaa atacaacaga ttctactaga 245101 agtactacga ctcgaagcaa gatgctgtta gatttgctgg aagatggtgg gtctaaaaag 245161 aaattaacag atgaagaaat ccagctgcga agagccgaaa atgcacgtaa aaggaagaac 245221 cttagcgaga agagactgga agaggagaag caggacacaa tcaataagct tttgaagaaa 245281 agggccggta agtctaggag ccacttgcca aatgatgatg aaaagaatga tggctcttca 245341 agtttcgtga aaccacgcag gccttacaat agcgagggta tgacaagaat tctgcggaga 245401 tatgaagaag acttattttg tacattttaa gtagaggacg caatttaagt atttgatgta 245461 tatcgtttgt tttatttctg ttggtatcgg ttgggctcgg tattattgtt acacccgcgt 245521 tgtcaagtaa atttataagg gtccaagata aaatgaaagc attgaaatat ttccatcatt 245581 ctgataagca gaaccacgta aggcagacta aaaatcatga catcgattaa cagttttccc 245641 aggaatattg actggccttc caacataggc attaaaaaaa tagagggaac taatccaacg 245701 gtgaatgcca tcaagggctt gttatataat ggtggatcaa tttatgcatt tctatatttt 245761 gttattgcta tgtttgttga accaacgcta caaaagcagt accagcagag aaatgatttt 245821 tccttgtttg ttttgttgcg tttgagaaga atcatagcgc aattgcaaaa acgactggtg 245881 atgaccccag tatcgtcgtt ggggttcaac gaacagaata actttgtgga gaggtccact 245941 caaacttcag acgacaatat aatacgagaa gataatagcc attgggctga aatgatttat 246001 caactgcaaa atatgaaaca agaattacag tattttaaca gatcctcagg ccaaccatct 246061 gaaagtatag acgattttgt ctttcaaatt aagatggtga ctgaccaggt tgagttaaca 246121 gataggtccc gagctttctc aaataaatca agaaatatta tacagggaat ccgagaaatc 246181 aaaggttggt ttgtgaatgg ccaagtgcca aggtaacaat caaaaataat agcattgaat 246241 ttaaaacgct ctagtgcacg taacgcatcc gtctgatcag tggcgaacaa taccgttatt 246301 tttcatagta cctaagaaga cacataccaa tttttgcaag tgaaagtgca gaaacggttc 246361 cactaacgat attactgcat gctctctatt ctaatgtaca tatatatgtt cctttatcta 246421 caagaagttt cgtaataata tataaatccc tcaaaagtgt tattgtttcg agcccaaatg 246481 cttcaaaatg tatagtttgt tggtgttttt cttttcaggt gtactgttgt taggcttgaa 246541 aggtttaaaa gtgcgaacat tccttgctat taattcaggt gaatttgagt tggacccaag 246601 tataatcttt ctgctagtaa caatttgatt ggatacaaaa tcggcatcct cttttctttg 246661 atacatttct tttatccgtt ctcctcttct tttccatctc tcgtaggtgt tattgttttc 246721 ctcatcagta cgcttccagt tggacttcaa aattcttcga acagcctcgg gagaaatttt 246781 gaaccggtct gcaagatcag atgctgtcag ttcaggaaag ttgaatttca atagtcttag 246841 agcctccatt tgttcctgtg atatcttttt tggtgggttc cacctctggc cttgcaattt 246901 ttttctaact gccattttct gcttcttcca ctcaggaatg tctttcgtac catctcgtac 246961 tttttctgta aactctttat tggacaaact cgatttattg actaatttaa taatcttttt 247021 ggatgaccat cccctgttct cattgagtaa tggaccgcag cgcaggcaat gaaaagaacg 247081 acatgctatt cgcagaatgt tcatgccaag tgctaaccaa atgattcaga aggaagtcga 247141 agggaatacg tagtgccttg ttaaatagct taccgtgata tgaacagtat acgatcgact 247201 ctccttggag actttctaca ccattggtga ttggtgtttt agttctacca tcatttcata 247261 tttactagct ttatgatcat tttagacgac tgtgggaatg ttgttatttt tactaatcac 247321 ttttacttag taatgtccct taaggacagc actgaaagca aagtagtcaa gcacttcatt 247381 cgaacttgat tagtagaaac aaacttcatt ctttctttac gtatccagtc caataatatc 247441 tgcagtagtt atagtgactg atgaacattt tgaagaagtt tatggagtct ggtaacaagc 247501 cagagctcat cacgatacct tctgggcagt ttaatctttt gaggtctaag aattccccta 247561 aagctgcttt agaatgtatt tacaacaatg caactttaag cgtacgtaaa ataggcaaat 247621 ttgattatga gttggcggtt tatagggtag aggacgatag tgaaggaggc acgggagatg 247681 aggctgagaa ttttgaagac gacaccatca gtgttttatc cacacagtct aaaaagaaag 247741 aagaggagtg gagcgttgaa atatcggata aaatcatgtt tcacaaaaca tgggataaac 247801 aaggaaacgt ggcgcttgtg tgggagaact taagaggtga tgaacaagat gaaaaggttc 247861 aatttgttgt tgccgctgat gtgtcgtttt ctgatgttga acagtttatc caaactgttt 247921 accgatgcca attcgaagta aggaataaaa aatcctctct cactgcctca gcagatgact 247981 taaaggaaat agagcataga tcaaccaggc tctttgttca agatgatgat gacgagttag 248041 attcaagctc agatgacttt caagatgcta aagacacctc ttttgagcac gagaaggaaa 248101 gtgaaatatt ggaaagaact ccttctccat tgaaaaaagt tccagaaggg gaatattgtt 248161 gtttagtgat gtctagccta tacatgtatg atccaattca agaaaaattt attctgcagg 248221 agcccgtggt aaaggtagca attattgata caggcaagta cgaattttgg ctagcgatag 248281 aaggtaaaga taatcgtctt gggactcagg tcgccccaaa tatcaatcct acctttgaat 248341 tagctaccga tgcctttctt ttcaactata cgctacaaaa cattacattg tcttatatgt 248401 taaaatttaa ggacttagat aagtgtattc aattcaggtt tgcttgggtt aaatgtttat 248461 ggatgacttt gaacaaagaa acgtggaccg acgttcctga aaaggagaaa gattatattt 248521 tagattcatc atccgtgcca ttggaaaagc aatttgatga cattttacac atagatgaca 248581 gatcaaatga ggaaagagat aaagaatcaa gcgaaagtga aaatgatagc gaagatgagg 248641 atgacgaaaa cgatcactcc aaaagaatca tttcatctga agcctttgaa gaacctaggc 248701 gtgcgacttc caaaggtaat agttcattga ctgtcgcctt taggaacaac aggtcatatg 248761 ttacaagaga taacagaatt ggtgtgttca aaacggatga tgaagacgat tctctagaat 248821 ttgtagctgc cataaagaat atttctaatt taggtggtaa aagcattgat cctcataagc 248881 caatgttgta tatggaagat cgtaatttaa ttttgactga tggcgaaaat gagaacaaac 248941 tttataagat ggatatagaa agaggaaagg tgattgaaga atggtctact ggtgacaaga 249001 atgttgttca atatggtcca accaaaaaat tcgatcaaat gacgcctgaa caaacaattg 249061 ttggcgtttc acagaaaggt gtctttaaaa ttgatcctag aattaacgga aaaaataaaa 249121 tagccgtcga tgaatcaaaa gattacgtgg gtaaatataa ctttagctct attggaacaa 249181 cagagagtgg ttatattgct attgggtcag aaaaaggtga cataaaacta tatgataggc 249241 tcggtattag ggcaaaaact gctatacctt cactaggcca agcaatcaag tttattacta 249301 cctctgctga cggtaaatgg ttattggcga cttgcgagag tactctgctt cttatggatt 249361 tgaaaattaa ggatggaaaa aatgctggca acattggatt tctgaagtcg ttcccagcca 249421 gtgaaaatgt taaaacatat gtattaaaaa tacgaccaga acattcggca tcaatcttaa 249481 cgtacacaaa aaaaccaatc cgatttacga aggcttattt taataccggt ataggccagc 249541 aagaacaaac tattgttaca tcgacgggtc cttatgcgat ttcttggtca ttaaagggca 249601 ttttaaatca agatggtagt aataattatc cttacagaat ccgtaggtac aatgctgatg 249661 ttgttgctga taattttgaa tttggttcag acaaaaaggt tatcgttgcc ttgaaagacg 249721 atgtctctct atcgaaagtg aaatccttta aacagccaag caaaggagtc ttgatgccaa 249781 gtgcttccct ccaagatttt tatggctaat tcttattttc aaggttttaa agttgtattc 249841 cgagtgtatt atatagttgt ttcccttccg gaagttgtgt aatatatagt tttgaatata 249901 tataatggtg ttaaatagaa atgccaaata gtacgtagta atattattta aattgcatgc 249961 gtttttttcg ttttaaaaag agattttagt gtgaaatgca gtcaaaaggt acttttgtct 250021 gttttatagt acttgtacat cagacaagga tgaattaatc ttttttaaag cggtctccta 250081 gtctccttct gaacccaaaa gtagatctca tttcatccca aaataaaagc cttaaagcct 250141 taaatttctg tcgtggagtt ggcttataaa gatattgaaa agcagttgat tggtcagtga 250201 aaggatcttc tttaatacca tttactttcc tatatacctt gcgtacaaat ctatggaaac 250261 ctggactact cagtaacttg tagtaaaacc attcttctat acttcttgga ggcatgctta 250321 aactgatgtg ataaacatat tcttgttggt aacagagtgt tcgttcaatc tttttaagat 250381 attttgtttc ctaatttctt cacatttttg aattactgtt tttcttaatt tcataacggg 250441 ttcttttcaa aaaaccgtaa aaatttgagg tcacaccaac taaatacaaa ttgtttcatc 250501 acggtgacta tatcaagaac ttcgtaagga aacatttaga aaactcaata tagtaaagtt 250561 tcatcagcaa tcttatctga gtaatattat ctacgatcta aatataggat gatctgccga 250621 tttaggaatc gtactgtaga ttgctcttgg cgacagatat agtgaaatac cttttacaaa 250681 gtggatacag gttgcctatc actaccgcca tttcactagc aagtagagta ttgagaaaac 250741 ggtaaacttt gaaagttgca gatgcagaat atatatctgg ttttgtagtt ctatccgcta 250801 aacgggacga tcgcatttta gccgccgaca gtgttaatat aagtaatgaa cttgggttaa 250861 tttgattacg cgtcacagct actaataaaa taagaccgag agttttaatc agctagtgca 250921 taccaaaaca atgagtaacc aacacagccc tcagccattt tgtttggaca ccaaattggt 250981 gaaactatta gaagagctcc aggagggaaa gcaattcaac aataaaaaca tattcccgga 251041 aaaagcatta tatttgaagc tcgctcttga ttattctttc ttcagaaaga atttactaga 251101 gttttgcgtc caccttgaca agataaaagg agtcattaga ccaaactatg acactatata 251161 tattttgtgc ctgttggagg tggatctcct caatctggta tttaccgaca atatattgga 251221 aatatgtttg cccaggtttg tttcaaggga ggacttgagg gtttttaata atacttttta 251281 cacatatcac gataaccgcc tacgtattct ccaagaagac ttttctcaat tgttcaaaaa 251341 aatcaaaact aaggcttctg tactatgttt tacagttgag gaaatttttc tgacaaacca 251401 agaaatttta cctcaaaact caacagtggc agaactgcaa aagagcacta ataaagtaca 251461 gacaaatggg ccgcaacggc acgatttcat agtcactcta gaaataaaac tgaacaaaac 251521 acaaatcact ttcctcattg gagctaaagg aacgagaatt gaaagcttga gggaaaaatc 251581 aggcgccagc ataaaaataa tacctattag tgataaaatg actgcacatg aaaggaacca 251641 ccctgaatct gttcaacaaa caatactaat ttcgggtgac ttatactcaa ttgcattagc 251701 cgtcaccagt atagagtctg cattaattac tttggattta tagattatgc ggaaatggtg 251761 ttggaagata ccagattgta agcttatttg atcgtttcaa tgatggctta tacaagatca 251821 cacttaattc gtatcattcg aaacggaaaa agaaatgtgg attttctttt tcaatttttt 251881 tttttttcat gatttttttg ggcgacgcag agatgagata aaaaaatttt tcaactgcta 251941 ttctcaatcg aatttttttt gttatcctca cctatttgtt acataaattt cgttattttg 252001 cacttgttac ccatcgtttt ttctttcaag aaaccaagaa ccaatatcct cattaacaat 252061 ggctgaaggt gttttccaag gtgctatcgg tatcgattta ggtacaacat actcttgtgt 252121 tgctacttat gaatcttccg ttgaaattat tgccaacgaa caaggtaaca gagttactcc 252181 atctttcgtt gccttcaccc cacaggaaag attgatcggt gatgctgcca agaaccaagc 252241 tgctttgaac ccaagaaaca ctgtttttga tgctaagcgt ttgattggta gaagattcga 252301 cgacgagtct gtccaaaagg acatgaagac ctggcctttc aaggttatcg acgtcgatgg 252361 taacccagtc attgaagtcc aatacttgga agaaaccaag actttctccc cacaagaaat 252421 ttccgctatg gtcttgacca agatgaagga aattgctgaa gctaagattg gtaagaaggt 252481 tgaaaaggct gtcattactg tcccagctta ctttaacgat gcccaaagac aagctaccaa 252541 ggatgccggt gccatttctg gtttgaacgt tttgcgtatc atcaacgaac ctactgccgc 252601 tgctattgct tacggtctag gtgctggtaa gtccgaaaag gaaagacatg ttttgatttt 252661 cgatttgggt ggtggtactt tcgatgtttc cttgttgcac attgctggtg gtgtttacac 252721 tgttaaatct acttccggta acactcactt gggtggtcaa gatttcgaca ccaacttgtt 252781 ggaacacttc aaggctgaat tcaagaagaa gactggtttg gacatctccg acgatgccag 252841 agctttgaga agattgagaa ctgctgctga aagagctaag agaaccttat cttctgtcac 252901 tcaaactacc gttgaagttg actctttgtt tgacggtgaa gatttcgaat cctctttgac 252961 tagagctaga tttgaagact tgaacgccgc attgttcaag tctactttgg aacctgttga 253021 acaagttttg aaggatgcta agatctctaa gtctcaaatc gacgaagttg tcttggttgg 253081 tggttctacc agaattccaa aggtccaaaa gttgttgtct gacttctttg acggtaagca 253141 attggaaaaa tctattaacc cagatgaagc tgttgcttac ggtgctgctg ttcaaggtgc 253201 tatcttgact ggccaatcca catctgacga aaccaaggac ttgttgttgt tagatgttgc 253261 tccattatct ctaggtgttg gtatgcaagg tgacattttc ggtattgttg tcccaagaaa 253321 cacaactgtt ccaaccatca agagaagaac cttcacaact gtcagtgaca accaaaccac 253381 cgttcaattc ccagtctacc aaggtgaacg tgtcaactgt aaagaaaaca ctttgttggg 253441 tgaattcgac ttgaagaaca tcccaatgat gccagctggt gaaccagtct tggaagctat 253501 cttcgaagtt gatgctaacg gtatcttgaa ggttactgcc gtcgaaaagt ctaccggtaa 253561 gtcttctaac atcactatct ccaacgctgt cggtagattg tcttctgaag aaattgaaaa 253621 gatggttaac caagccgaag agttcaaggc tgctgatgaa gcttttgcta agaagcacga 253681 agctagacaa agactagaat cctacgtcgc ttccatcgaa caaaccgtca ctgacccagt 253741 cttgtcttct aaattgaaga gaggttccaa gtccaagatc gaagctgctt tgtccgatgc 253801 tttggctgct ttgcaaatcg aagacccatc cgctgatgag ttgagaaagg cagaagttgg 253861 tttgaagaga gttgtcacca aggccatgtc ttctcgttaa gatgtcattc tggttaaggt 253921 tatacacata tatatatttt tcatttttaa tgtcttagct tttgtatctt agatgaagtt 253981 ttagttctgt atatcacgat caagatatca tacaatcata aattcaatta ttcttctgtt 254041 tcccctcttg aggcatcaaa cgagtgtttg actgatacac accaacatac taaggcaact 254101 tttctggctg cccaaagctg tggcacgtat gaaactgctt ttcggctgca taaaacaacc 254161 atgtggagtt tttactgtat tcgcatttcg ccccgctagc attcttcgtt catgctaaaa 254221 atgaggcgtg ggctaatatt cagtattaat aattccggca cccgcacagc ccataccgga 254281 aaaggggctg gctgttgggc ttggcaaaaa actcaatctg agcagtcatt tataaagaaa 254341 gactttaatt tgtcttgcta aacacttgta agccttccaa atatagatca cttaagacaa 254401 tctaacaagt gtccaaaatg tctgcaaacg aattctactc aagtggccaa caaggtcaat 254461 ataaccagca aaacaaccaa gaaagaactg gtgctccaaa caacggtcaa tatggtgccg 254521 acaatggtaa ccccaacggt gaacgtggtt tattttccac tattgtaggt ggcagtgccg 254581 gtgcgtacgc tggatctaag gtgtcgaaca accattctaa gttgagtggt gtgctgggcg 254641 ccataggtgg tgcattcctt gccaacaaga tatctgatga gcgtaaagag cataagcaac 254701 aagagcaata cggcaactca aacttcggag gtgctcctca aggtggacac aacaaccatc 254761 accgtcagga caataacaac aataacggtg gatttggcgg tccaggcggc cctggcggtc 254821 aaggtttcgg aagacaaggc ccacaaggat ttggaggtcc tggtccacaa gagtttggtg 254881 gtccaggtgg ccaaggattc ggtggtccaa atcctcaaga attcggcggg ccaggtggcc 254941 aaggattcgg tggtccaaac cctcaggaat tcgggggcca aggtcgtcaa ggattcaatg 255001 gcggttcacg ttggtgaatg gctcaacaga gtgagtgtca tttttagcta actacatact 255061 tgatttatct atatatacat atatactact cgttttatta tgatgtcgta acaaatgact 255121 tattcgagaa aagaaaacgt gaaaaaataa gctaaaaatt tggcgatgag gttctctgtt 255181 gaagttggaa cccgcaattc atgattttgg taaggtcaag gatcatcagt aattagctta 255241 aagtaagaac tactcaataa tattaaacca tttatccttg gctcgtcttt ctattgacca 255301 atcaatacta ttttaaacat ctcttctacc acatactttc aatcagacta gaatgaaatt 255361 ggatacttct catatgagat atttgacaac tgatgatttt cgtgtcctcc aggccgttga 255421 acaaggttct agaagtcacg aagtcgttcc aactcccttg attcatcaaa tctcggggat 255481 gagatcgcag tccggaacaa accgagccat tagtgatttg gccaagctta gccttatttc 255541 caaaatgaga aatgtcaaat atgatggtta caggctaact tataacggta ttgattattt 255601 ggctttgaaa accatgttaa acagagacac tgtctattct gtcggtaaca ctattggtgt 255661 tggtaaggaa tctgacatct ataaagtaag tgacaaaaat ggaaacccta gagtaatgaa 255721 aattcacaga ttaggtagaa cctcttttca ttccgtcaga aataatagag attatctgaa 255781 gaaatccaac cagggggcaa actggatgca tctttcacgt ttggcagcca ataaagaata 255841 tcagtttatg tccatgcttt attctaaggg tttcaaggtc cctgagccat tcgataactc 255901 gcgtcatata gtcgttatgg agcttatcga gggttaccca atgaggagat taagaaaaca 255961 taagaatata cccaagcttt atagtgatct gatgtgtttc atcgttgatc tagcaaatag 256021 cggacttatc cattgtgatt ttaatgagtt taatattatg ataaaggaca aactagagga 256081 tgaaaacgat tgtgggttcg tagttattga ttttccacaa tgtatatcta ttcaacacca 256141 agacgccgac tattatttcc aaagggatgt tgactgtatt cgtcgtttct tcaaaaagaa 256201 actgaagtac gaaccaaaac ctgattcatc aatgctcgac actgaaggtt tcggcgatgg 256261 ttataaatat gcgtatccag atttcaaaag ggacgttaaa agaaccgaca atttggatga 256321 attggtgcag gcttccggat ttagcaaaaa gcatccagga gataggggcc tggaaactgc 256381 cgttgaaagc atgagaaatg ctgtttataa ttcagatgac gatatgtcta atgacgaggc 256441 cgaagaagaa aatggggagg gcgattattc agaggaggat gaatactatg actccgaact 256501 tgataatgaa agttctgaag atgacagtga agatgcacaa gaagaggaga acgaacgtat 256561 tatagaggcg ctttccagtg gtgttgaaaa tctaaaaatg gataaactag gaaactatat 256621 actagagtag tttagtttag acgactgcat aaatggccgc aaataatcaa gttgttatcc 256681 ataatttttt tgatttttaa gccatgttat tcttcaggat aaaaaaagtg gtatttatga 256741 actcttacat atgcgtattc atgctatatt ataatatcga atctaagtca atcgtattct 256801 actccggatc catcctcatc atcttcatcg tcatcattat caatttctat cggaatatct 256861 tcgagttcta acggctcctt aaactctttg tattggagtt cctgttctgg ttgaccattt 256921 atagaagcaa aactattatc tctattcaaa gcgctttggc cctttttgtc ttcctcttca 256981 tcgtcttctt catcatcttc ttctgcttcc tctccgtctt ctgcaccgtc tgaggattct 257041 tggccactcc catcggaaag gtcgctctca gcttcgaaat tttggtcatt ttcttcatca 257101 tcgtctgaaa acacacctgc ctttttctcg tcttgcattt gacgggtagc ttcctgtaga 257161 atagatggct gatcggctgt gccatcagtt gcttggcctt tgctcttgga tttagctttc 257221 aattcctcag acatagactt atccttcatt tgtttccttt taacgtagtc gtcaatttta 257281 gcgtattcag tttggtctat catggaaaac tcgtattttt caccatcttt tgtcactaag 257341 cttgcattga atgttaatct ggtaatagac gaataggtta tagactcgat gtcagaagcg 257401 tcgaataaca aaatgggctt tttaaaccca aaaattatat gatctggtaa aaaatatagc 257461 gtgccttctt tagtacctct atgacactgc aggtgaaatg agtttatttt ttcagcatcg 257521 gtatccacca gtgtactgtt aacgaatggg ttggagattt taaaacccgt caaaatggct 257581 tgctttctta tatattcgac gcacttttca aagtctgtta cattggaatc aagaagccct 257641 aaatttttaa actggtttag tgtgttttct ttgttcaagg tcattaccac aggttcagaa 257701 aacttgttat cctcgcacga tgtgtaagtc ataaaaaggt atattagatt aggcttttct 257761 ggcactggca agaacgaagc cattttgata tttttgttca gctgataaat gcttaattcc 257821 ctgtcatttc ccttcagtaa tgttattacg ggagacccgt caacattgga aagatagaac 257881 accaaatcaa gctttttcct taatggtgac agtacagaaa caccttctaa tttgaaaata 257941 gtattggttt ccgaaatttc atctgtttta agcaggtcag aagagacatc tattctgggc 258001 tttttatggc gtccgcttct atcgttgcta ttttcattca atgcatattt atacaattcc 258061 tcaaatattt ctaatgagct tggcagcact ctaaccacgg taccaatctt tcggctgaga 258121 gactcaggca gttcatctaa gaacaatttt gacatcaaat ctgtaggact ttacgtttga 258181 atagtggctt tttggtcagc gtttccagca cctttacatc atagttatta ctacacacta 258241 atgcgctata gcgtatgtta gatgaaaaaa aaaagcacga cgcgtcatta actagtgggg 258301 taacccacga aataaagata aaaaaataaa attcgtttat atttaaattt ttaaagcata 258361 tgttcttatg atgtctaatt gaattctgga gggagaatgt ctcccccagt aaaacaagaa 258421 aaaactggcg agggtaaatg gggcgtttca tgcaacttct cgttaaagtg cacgaatgat 258481 ctcttgatat cattcggcaa attcctttgt tgaatgtttt caatcgttgg ctgaacaacc 258541 gagcctttaa agtcttcgta tgatttgtat aatgcatctg aaagcaactg ccaacttcta 258601 gaaatggttc ctatggggtc attttgaaat ttttcaattg ttaacgtact cgtagcactt 258661 gtaacgttat tctcgtccag gtttctttcg gaactcaaac aagcgggaaa tctttcgcag 258721 tcttgaaaat tgtcagagcc taacaccttc tcaggtagta caaattccgc cccttccgaa 258781 gcattgctgt tattagatat ttccctcaac gtcctatctc ttatttggct cgtcgcaccg 258841 tttgtatact gctggaaatt attgaatccc aaatacatgt tccgattaat atcattactg 258901 cgcacttcat tggccagcct cctcttgtaa cttttagcaa acaaattatc atatttttca 258961 cgcaatggaa tcccgttctg caaaatacca tttttggaca agaaggaacc gaatctgtta 259021 tttccgcttt tctctactct tctgacatcc ttttcttcaa aattatccat tgttattgac 259081 tttacacaaa atatgttcgt acccatcccc ctcaaaaggt ttgcgcaatt aacacatata 259141 aatatgccga agctgcaaga aacaaattgt ggattgacac tcttgcattc aaaacaattg 259201 ttattgccgg cagccttctt ggcacgtaac aatctcttcc ggttttccat atctttacta 259261 ttttcaaaca aacgcatggt ccatatattc ttgggtccct tttataccag tactctcttg 259321 tagcttgtat aatttgtaaa ttagcgttgt ttttactatg cgtttgctgg cctaacgtca 259381 caaaatcact ttcaaacggc gcgtacactc acggcgttaa gtatatcaaa ctccgtcact 259441 attggagttt accaaaaagg ataggtataa gagtaaggct ccaaatcaaa gaaaatctaa 259501 atttgaaaag aagttcgtaa tttctaatat ttacactttt agagtttggg aggtcgtatg 259561 ttcgagtcat ggatactatg aatacagcaa acactttgga cggcaaattc gttactgagg 259621 gttcttggag acctgattta tttaagggta aagtggcatt tgtcactggt ggagctggca 259681 cgatatgtcg ggtacagaca gaagccttgg ttcttcttgg ctgtaaggca gctattgtcg 259741 gcagggacca agaaagaaca gaacaggcag caaaaggtat ttcgcagtta gcaaaggaca 259801 aagatgcagt cttggctatt gcaaacgtcg atgttcgcaa ttttgaacaa gtggagaatg 259861 cggttaaaaa gaccgtagag aagttcggta agatcgattt cgtcattgcc ggtgctgctg 259921 gaaattttgt gtgcgatttt gcgaacctct ctccaaacgc cttcaaatct gttgttgaca 259981 tagatttact aggaagtttt aataccgcca aggcatgctt gaaggagtta aaaaagtcaa 260041 aaggttccat ccttttcgtc tctgccactt tccattatta tggtgtgccg tttcaaggac 260101 atgtgggcgc tgctaaagcg ggaatagacg cattggcaaa gaatttagcg gttgagttgg 260161 ggcctctggg tatacgttcg aattgcattg ctccaggtgc tatcgataat acggaaggct 260221 tgaagagatt agccggcaaa aaatataagg aaaaggcctt ggcaaagata ccattacaaa 260281 ggcttggatc tacacgggat atagccgaat ctactgttta tattttttca cccgccgcat 260341 cgtatgtcac cggtaccgtc ttagttgttg acggtggtat gtggcattta gggacctatt 260401 ttggacatga gttgtatcca gaagccttaa taaagagtat gacatctaaa ttataatacg 260461 tataggtatt gagtactatt attatatgac actttctcgt atgctttttg atagttaatt 260521 gtatattgat gaattttata tacaatgagt gcactatcgt tgttaaactt cttacaacca 260581 tgaccgttgt gctagctttt tattcttctt tccaacaagg aaaaactcaa gtacttgcat 260641 tcatttggtc aacgcttttt ttaaatgcta actgatcacc agaataatgg gggtcatttt 260701 caaagtgttc aatctcagaa tgtaatcttt tgacgttttt aatgtcaata tcttctaaat 260761 gattcgaagc aaatccatct gttgacatat ttacagaaat gtcattcccc ccttcaatgc 260821 tattttcaaa gctagaatga tcgggttggt tttcttcccc ggtttctagc atatcctgga 260881 tgaaagggat atcagtagct tttctcaaga catcaccata tgtttgaact aagtatttgt 260941 ttaaaatggt aaagtttgtc ctattgttgt tcacgttcgt tttgacgtca ttaccgttgc 261001 catcataaga accattggtt ttttcctttc tgttatggcc atcactttga taagctctac 261061 attctgttat aataatgcgg aaaaaatctt gaatgcatga atttgcaaga ttattcttat 261121 ctatgttctc ctggaagagt ttaaaaaccg gcgcatataa attttttgaa atcatatatc 261181 gatgatagta tttatcatcg agacacataa ggtttttaat gcatcttact gctgttaacc 261241 ttagctgcat catatgatta ccgccgataa gtttgctaac agaatctagt ataccgtttt 261301 ctaatatgaa tcttctggat aagacacgat catgctcagt gcaaacaaat gataccaatt 261361 tcactaaatg aattaacaaa agatcgtctt ttgtaacctt ttctatttgc ccatctattt 261421 ctgccatttc cgttgtgata tccttcttga ttaatggacc aaacagtatg ggtgcgattt 261481 tattatagaa atttgcaaaa tattccatta cttgaaattc agattcagat tctggctcta 261541 gattattcat ttcatcgctg ctatagtgat agttatttaa attgattgaa tccgagttta 261601 aaccataact gaaacttggg aaatcttcag atgtgttctt agcttcataa tttgatctgc 261661 ccataagatc atatgaacct tctccattac ccacacatcc ttcagggtga agcaaagtat 261721 ttagcgcttg cacaacttgt tctcgcaatc cgggactcct gtcggacaga agaatggttg 261781 aaagtatcaa taacaacttg gaatcagtac tggagctgta atcctgcgga tatttccgat 261841 gggaagactt gtcatcgggc gctgatttat gttgccgttt gaaagaatct tcattctgaa 261901 cgttgtgaat taacaagata tcgtgttcga ttatagtaat gatagtatcc gtagctaaaa 261961 tcctaacatt actatccgtc tccatgtgaa atgcataatc taaaactttg aatagaccct 262021 ttcgaacaag tgttttatag aacttagaac ggtcaaccgc atctaaattg attgacattt 262081 gaacacactg ttgcaacaat ctaatcccgt cttttcgttt ttgtacaaac ttctccttct 262141 ctgaagagct ttctggaagg gttttggtat cataaagctc tattagtctg tccaaaaacg 262201 tccctacttg aagaaagtcg attatacacg tttccaggtc catgacaatt tccgagatta 262261 agttgaaatt atgatcgtct aaaaatcgta ctaataccac gtcttttaag aactgtaagc 262321 gaaaacattt tttcattatt atttttaagt cctcattttc caatggaata acctctttga 262381 aattgggacc ttttgatcct aaatatttcc tatgatttgc ctttgatgta gggtattcag 262441 tatcgtattc taaaatccca actattccca taatcctatc gtcctccacc attgactcca 262501 atatgtctct tttattgtaa agtatcaaag ttttgatgat gttacttagc aaaaataaat 262561 ccttcggtat cttttcttct tctgctttgt ggaaatgaga aatcagtgta tcaatgtaat 262621 ttgactggag gataaactca atggtttcgt ttttcaaaaa atcgaaagaa gtattttcat 262681 tcaaaatctt tagagcttct agtaaagttt gactattctg ttgctggtcg ttggagggca 262741 aggtcacagg gcccgttata atgtcgtgaa cagacccgag tccgttgtcg ctggatttta 262801 cggtgactaa agaaatattt gactctatgt tcctttggac gtgaacaatg aattcacata 262861 aggtgtcaca tcccatactt tcttcaaaac tcaaggctat atctttcccc cctaaatcct 262921 tccaaacaat aagcgtttcc tcctgccgtt gatattcaat atttccttct agtttggatt 262981 ttagtaaagt ttcagttggg gagtcttcat ctgagacaac aagatatgcg aacttacctt 263041 cgtccacctc ccctatacaa aaccctgtac ctgtgtcttt ccattcgttg ttctctaaaa 263101 tgtaaacctt tactcttttg ggttcagtat taaccgaaac ggcttgttca gtatcctcat 263161 ccatcggggt cggagatgta gtaggtgtac ccggtaatga cattactctt actatacgta 263221 aatcctaaac ttttcagtta gaatttctgt ttcaaacaca gaccaaaaaa aatactgttt 263281 tctaccggtt taatatggaa taaatgagtt tcgatgaatt atagtaccag ttcagtacac 263341 tcttctttat tttttttttt ttcagtatgc gcgggttttg aaagcactag gtcttttaga 263401 ttttacgtca aaggaggccg agaaaatatt gttaactatg ccactgatgc aagcaatctc 263461 tattgtgcaa ttctagttat atctaccttg caattgccct ttagaaagta ttggtcttct 263521 ttcttttgtt tcttcttcgg atgaaacacc aaaggaaaaa aaaaaaagac agatagaaaa 263581 agaaaagatg gcgcgtcaga aaaagaaacg acggttttat catcttaaaa gagaatcatg 263641 atggctattt gttcacaaaa taagggatta tataaaaatt atgtatggta gtggcattat 263701 agatttgggc tatcagagtt tcaatatttg gtctgtggat tcatatccaa atggctcaaa 263761 gccgaattta ttggcgaaat ctcgaggaat gaatcttccc cccacgtaat gagttgtttg 263821 attctccctt atgtgagagc tgcatggctt ggggacagtc agagatacaa gaacagcagg 263881 attaattgag ggctgagaga tcggaccttt gtcaacgtcc caacctgtgg ggacgtccac 263941 cgaaacaatc gggataatgt tttgcacttt gcacagttct tcgacaatgc ccttgaatgg 264001 ctctctcatg ggaggcttga aactaaaacc aaatattgca tctacaatgc ataaggtctt 264061 ttccggcttc aaatattcca gccagtttcc ctcatcttga gacaggacag gaactttgaa 264121 aaaattcaat tggtgaacca gctgtttgta gaattcagtg cgctcgcttc tcttggggta 264181 gaaaacaaca gggttgtaac caaaaagctt caaatgtctt gcgcacacga gaccatcccc 264241 gccattgtta cctggcccag caataacaaa tacatgtttg cccttttccg tttctgtctt 264301 gcctctcagt ggaaactggc gacatacagc ctgcgcgaca ctaaacccag ctaactccat 264361 tagctgttgt agagtgaatc cgatttgagg acccatcaat tctttgtcga tttcagctgc 264421 aagctttgat gaaacaactt tcaacgtaga catttttacc ttacaatgat ttctctttaa 264481 tacctgagat tggtgtgttg aaatgaaaat atgtgttggc ccagcaacag acaataatat 264541 aagcaaggat cctggtcgtt tgatattctt cttgagtttt tttcttatat atgaacgtat 264601 gtgtatatat tcaccatccc tattgtctcc accccttgtt cgctcgtagc gacggaaaca 264661 atcaaataag aggacccacg gtaaaagtag cgtaaatttt acggttctgc tgcaaaataa 264721 agaaacccat tttgtatcct ttacatcagg aataacgtaa aaagaattat cattagttcg 264781 tagttatata ataacgtctg ttcattataa aagagtacaa gaaacagtaa gatagtaaac 264841 gtcactgtta aatagttaat tataccgcca atctacacca gaaaattaaa agagaaagca 264901 atatatgtta aacattatta tcgtgtcatc tttgtaaatc ccttaacata cttctaacac 264961 aacccatgtc ttcaattaac attttcctta accactgcgt ctcttggcgc tgtaattcca 265021 attctctttc taattgcaca attctttggc ctttttcaga aatgattgcg tcataagctt 265081 ctttcaatgg gcgtatcacg gcttctgtat ctataggtcc catgctgttt gaaggattta 265141 aatcaacttt catttgggtg ttattcgcgt ttaaattagt gtccggacca tcatttatta 265201 acgcaccctc tgctgcagtt gtcatcggcc tctgcctctt actcgtattt gtcagttgca 265261 aaagttcttc caccgcttcg tcatccagcg tattaacatc taacgatccc agtgaccttc 265321 gtttccacga atgggatcca ttattggaca ttgtattata gcccatggta ttactggaag 265381 cattggggtt cagatctgca tgactcaaac caaattcaaa tcctcctgag ccaggactgg 265441 ttggctgtgt ataatatcct gtcaacgaac gagaattgac atcttgtgat agcgtttgca 265501 gtcgtttttg taactgttga gacaatgatg gatcaaaaag catattggta cctgggttgc 265561 ttattgttgt attactgaat gcactcgtat ctgtaatgcc gtttctctct ttattactat 265621 ttttattgtt tttcccattt ttagcatttt tagccaccct ggtgcctctt tttttcgttc 265681 ggttgtttgg catgttttta tttccatagt tcttaatatt actcccattt ccaatattac 265741 cattgttccc attattgttc ccgttgttta ttccctgtaa atctgatggg gagcctttag 265801 ttgatgtatt taaggagttt cccttcctgc gtccttgagt tagaatttgg ccggtctgag 265861 gatcgaatac tgtaaatatg ctcattgaga ctaatcgcca caattcatcg ttttctaatt 265921 ctgagtctgt ctttatttgc caaagccttc catccaaccg gcggaagtat tttgcgtaag 265981 gacttgcgtc aaaactcagc tctagttcct taatcatctg ttgaaatctt tgatatagtt 266041 cgattgccga ttttggtgat gttgatctat cgtcaattga cccagatgat agtgtagcgt 266101 tatatagttt tgatattttg gcgaaaagtt gagaatattg cgcttgcgta tatattccat 266161 ttgaggtggc actagagctc gcattattac cagtagtggc aggattgctt gcattgctaa 266221 tggctgaggt agaacttgaa ttaccattcg gcgtaccatt agcgctatct gagttggttt 266281 tcgtcagagc attactacca gtgctagtta taatctcatc gatgttaggt gtgctatcag 266341 accccatcaa ccctgttgga ttagctatcc ctgttccaac cgccccgtta accatacctg 266401 agggcgtgtt cgttgtcgtc tgtggcgagt ttgtaacact ctgcaaggaa gcaccactaa 266461 tgacagactc gttagacagt aaattataag ctctgattat gaatacatct aacttagttt 266521 ggtgatgcat tatgtgagtg taacttttcg tcaaatactc tttgtgttct caggttcctt 266581 tttggtttct tggttgtttt cccattcagt ctaggcgtaa gaatgtgaag aaagtcaaat 266641 acagaccgca agcaccttat ggatgcgtta atgattatta tgtctaacgg acaactatcg 266701 cagaagtcgc ggtacttgaa ggagaaaagt cgtgaaaatt ttattttgga caaattgtcc 266761 aagaaaaata agaaatatga cgttattacc cgtattgaga ttccattgaa agacattcat 266821 aaaattgatc agttcggtca taaacaaagt agaacttcga aatatcaaat atgttcttgc 266881 cactggtagc ccatattttt ttaatctgct cttgtagcat agggttgaaa atattacatt 266941 gaagtcgata ccgatatata cttctataaa aatgagttct ggaataaaag taaggctaat 267001 acatatatat agtgggagaa tatccaaagg cagagttttt taaacaagga aagaataaaa 267061 gttggcagca taaaaaaaag atattctctc ttcaaaacat ttgtcggata tgacctcacc 267121 taagcacttg gtgctttgat gacaataatc acactaaaga gcgatattcg atagtgagac 267181 ttttccctct caatcttatt cacattagcg caagcaaaat ggaatgaatg gcacattaaa 267241 attgaaaata aaagttcttg ttgttgcaga agcggtatag gagttcgcaa aatggtagtt 267301 aagaaaaaag atggcgggtt taattcatag tacaattcaa atgttagaca gaaaaagaaa 267361 aaatttctgt tatatgcacg ttgtaatgta atagtaaaaa gataatttaa cgtaattgaa 267421 gagataaagt attatcgatg ttattcttat tattagtcgg tttagaaaat attattataa 267481 caaataataa aagaaaaaga aaaaatgcga cagaaaatat tattcttatt atagtggggg 267541 aaagatgaaa agcaatgcat ataatgtgat acatgcaagg aaatcaggtt tttgcggaac 267601 cattttttta gttttttata tgaccaacat tagaattgta actggaaagc atatttacat 267661 taggatttgg gttaccactg cctcctcttc tgctgtttgg gcccctaaca cccagtgggt 267721 tttttgaaaa gcttaatctg atacctccct tactgctcac agtggagcga ggtaactgtc 267781 taccatacaa ttcagctaac gctctggttg caaaactgac atcatcgaat tcaacgaagc 267841 acatcggtcc gtgactatga ccattagatg tggtattctt attcctgaat gatagtcttc 267901 tgaagccttc ttgaccagaa aatagctgtc ttagttcttg ctcagtagcg tcggagggta 267961 aattccctac ataaagggta ttacaaggtg gattttgatc agcagggttg gcaggaggtg 268021 gaattctggc tagtagtgac aaatcagcct gagaaatcga ggcagatcca gtaatatttg 268081 aggataatga ggtagtagag ttattcttgt gtgaatttct acttgaactt aatcttgcgg 268141 gcggtacttt ttgaggagtg ttactttgat tcacaggata catatgctct ggttggggtt 268201 gttgcataaa tctgttctgt ttttgaggtg taatgttcat atcagaggtg tttaccatat 268261 ttgaaatgtg ctgcgattga gaagacatta aaccgtatgg aggcaatgaa tttgaagagg 268321 ttagggaagt gttaatcgtg ttaccaattt gcatcattgg ttgttgcgag ctggcagaga 268381 gtgcctggtt agcaccatta ttgctggctc cattgttgga gctggcgttt gcattggcac 268441 tggtgttgct attcgtaggt gcaatggctg tcgatgctgc agagggtaaa aagaacgaag 268501 aaccatgttg ggatgcagaa gtatttcccc attctaaagt tggcgtagaa ggttggggag 268561 tgctcatgta accgttgatg ctggaaggta taccgcttgt gccccatatc ttttcattaa 268621 tttcagtgtt atctctcaaa aggaaagatt tgccaatatc agatgtttga attgttgatt 268681 ccacagacaa atcttgatgt gaatggttag aatgtaaccc aataacctgg ccttgagaag 268741 ataacggtat tgaagaattc acttgttgtt gattacattg ttgtggtgaa tgtttttgcg 268801 tagagtgttg ttgtggctgt tgtggctgtt gctgctgctg ttgagattgc tgttggctta 268861 aaggagaatc attggaaaat ggatcgctga atgaaaacct ggatctttgt gataacagac 268921 ttggcctttt cattcccgag ttcgatttat tcaatcttga ggtgtcattg aaaatggcag 268981 atgatgggaa tgaaaccaag ttttttgttg tgtcatctat tatttcaacg gttgttttat 269041 tgggaaaact gggtccaaag agttcatttt tcgaattcaa aataacggca taattaatag 269101 ctagattcaa taactcaaat ctggcaatga taaaaatatc attctcgtct tctaatgagg 269161 cagaagtgat gcttgatgaa gagttttttt tctgtaattc tatacttttc acaccttcag 269221 caagagcgaa gattgcatag cattctctga gagtaatatc cttggctaca tttgacaatt 269281 ttaggctgta gctcccctta atgttgttat cgtgattgct aatgttgctg cttgcaatgt 269341 cttggggcat acttccaagg gcaagtgtgt ttagcataga agatatcgct aagggtgagt 269401 ttgtgtcatt caaatacaac tccccacttg cgcttcctct acccgacgct tcgtggggat 269461 gagaagtagt gttcagattc aaactggaac gatgactggg agaaatgttg tgtgtgttgg 269521 tggtactaga cacaacgttg tcgctactgg acgcaaatga ccctgtttgg tcaaaataaa 269581 ctgaactttg catgctaaga gatacaggtt tttccctctg aaatattgat cgataaaggc 269641 tgctctaggt aagtgacgct tacaaatatt tgcaactcac agaaaagtga tgacaaagac 269701 ttttaacttg aaatgatatg atcagttgag aaaaagctgg tgaagcaaat gaaaaatacg 269761 ggaagaaaac aggaacagaa ggttttcaaa gtacacgact tattttctct ttaatgctaa 269821 ttgattgaat aaagagaaga cagaaaggaa actgacacgt aaaatatgtg gacggaataa 269881 acaactgtgc gtgagcagcg tttcaaaagc cttttctttt tggaggtctg tgcttgttta 269941 aagaaggcaa ttcaatcagg tggttatact tgtttattcc ggcttacttg gtcgtgtttg 270001 ttttttcttt tgacctctca tgtccgaaaa ggtccaaaac aacgagaaaa aaaagcagca 270061 atcagttacc ccatttaacg cgggtaacaa taacgattgt tctaaataga gcagatatcc 270121 aatagttgag aacatgaaga aggatggcga tagaatcagt gcgaagcagt ctaaagaagt 270181 tcctttccct ttcctttcct tttattttgc taatagtatt tgatataaag atgaaatact 270241 ataagaagtt tataaatttt ttaaattaga aaagctaaat agcagcttga tcgcaacaag 270301 tggggaattc tgaccagcgc gacgcttgtt gcatggttat tcctgcatct gggactggtt 270361 tttcatccat acacaatctt tcaagcccga tggtgacatt tttgaccttg tttgagtatt 270421 ccatctcttg ctgcagtagc tttttacctc tctcatgcag accattagat gatgcagata 270481 tgttaagatc ttcggtaatt agcgctactg aattgaagga ggttatgtcg ttgtagttga 270541 tattatattt gggatcagga actgatgaga ccgtagtcgc attactggtc gtgctgcagt 270601 ttgaccagcg tcgttcccag gaggtgaact ccatgtcttg aaggacaaac tgactatctt 270661 tcgagacgtc gaggacgtta tcattgaaaa gttccgtgag ttggacatta agaggactag 270721 atgtttgaat agcctgatct atcatgatct tggacacggt ttgatggtct atgtcaaaat 270781 ctagtccagt ctgtggttta ggtttaccat tttcagctgc tgtgttctga ttaatggctt 270841 ctgaattcgg ttctttgaaa cgaaattctt ttgccagtga taattttttc tgttctttta 270901 gccttttgtc ttctcttttg tagttttctt tttctacttc ttttggcttc tctctatctt 270961 ttctacttgt attttttttt ttgtttttag ccattttatc taagaacttt ttcctttctt 271021 caccaaaagc tctcatttta tccttttccc tcttagtatc tatttgatca acatttccac 271081 cttttgattt atttttcttt acttgtcgat cttttggtag tttcacttcg tactttttgt 271141 aaccgatgat ttgatctact ttattcatca taacagtaat atattatgtt tttgattttt 271201 actatactga ttaaggtaga aaatgggacg atcttgcttt ttgtgtcctt tcattgaagc 271261 actgttattt atacggtcaa ctgcagccgg gcataatttc ggcggctatt catattgtca 271321 tccccgcact ccttctttga cagcacgcaa gcacatggag gctgataatg ccctcccata 271381 ttgtaataga atatatttat gcaataaaga gaacgcaata gctgcattta accaataaaa 271441 aattcgttat gacaataata tgtagacaag gatataaaag tataaggttg gttataaata 271501 aaaactgtag gaaaaacaaa aactacttat gcaagacctt attctcaggg tgcgaaatac 271561 tatgatcagt agcgtttaga acgttagccg aaggattagt ctcatccata atttggtttc 271621 ttgggacatt gtgccgatca cccacaccgt aggcgtaggt ttccttttcc tcagtttcct 271681 gattgaatga tggaatactt gcgggatatc cctgcacttt agtggtgtaa gaagaagcag 271741 agacgccgct attttcttct ctcatcattt tctcattgta cctgtctgag gaagccgttt 271801 gggggtccat catgtcttgg ttgttattat cggcacggcg agaagaaacg ctgttccacg 271861 cgtcgatgtg atgaggttga ctttgaggtg aacctgcacc gggaacatgt tggtcgatag 271921 gcccattgaa gtgcggatca gaggtgtctt gacaaccaat cggcacgttc ttgctgttca 271981 ttcttgcctc ggtcatttta ctactatcaa aattggctag cgtagaccta gcgtttttgt 272041 tatagtcact gaccactcta tttgtgactt tgccacatcc cgggataccg atgctaccgg 272101 caccggtgtt taaagtaggg cctgggcatt cagttggtaa aattccagag cgctgttcgt 272161 gagacgaaga gtgtccgtca cgatgaggat atttgaggtc gcttgccctg ccacaccctg 272221 gaacgctgta cgttttatcc tttgcctggt tcatattgag agcatcatca cttgcatatg 272281 cttgagcaga ttggcccaaa cccagcatcc tgtcataaga tttgtcaata tggtagccga 272341 agccgtgctg tgtagcagaa gactcttggt ttgtgtctaa ttcattgctg tcgaaatagt 272401 gaaaagaaaa gaaaaagagt tagtaagatg tgtatgatac attaaaagga agttaaaata 272461 cgatttcttt ttattagatg gtatcattac attgtttgac gtatagtatt agtattatta 272521 gaggttgaga attaaagata ttatatttag ggaaacataa aagattagtg gaatatcggt 272581 gcaaaatatt agtaataaat aaaattggta tcaacagaga ataggagaag gctaatcgct 272641 gcaattaggt ttgttattat ttgtaatcct agctttaata ataagggaaa aaaaagcctc 272701 ctttgcaccc tatgatacaa caggaacatt ctgttcagta tagacgcgtt cctcttgaac 272761 ccggtctggt tcatcgcctg cgctagtcac agttctcttt ttcgttctca atttcttaaa 272821 gaacctatga ttctggtggg attgagattg ttggacctca gttacaggca ccgaggaagg 272881 tattcctcca tttgttggaa ctggagttgg agtttgtgag tccactgtct tggtagaagc 272941 gaaactgcgg tcatagatgt actcgtttct tttatgagta gccaccatga tagtacagca 273001 aatggcgttt acaattaaca aaaatactgt ggtccaaata agcccaaaat tcttgggacc 273061 tagtctagca tcacgattct catggtgaaa cgcctttact gccttagcgt aacatcctgt 273121 gtacagacaa gcggataggg ttatgaagaa aagcgtgatc cagctcattg cagttgccag 273181 agcggcggta cgtctattgt atctgattaa actggcaata accgaaacta acgtgattaa 273241 caaaaagaaa agcccgatta gaagcattgc ccagcccact cttgaaagat aatagtaggc 273301 atttctgttg tttaaaaaag ttgagggcat gaggggggaa ctgccaaagt tgtcccttgg 273361 tgaaaacggc tgagctgcca tcttagaaga gcagttgact gctattccgc ggctttccca 273421 gccgcaccag ttataattgt accatctggt tacggagggc gccgagttaa agcccgaagt 273481 ggatgcctga aaccaataaa aattcttcaa cactcctgtg gtcctgccac ctgctagtat 273541 cagaaaaaaa gtcaacaatg tagcccctag tagaaagaaa aggttaataa agtacacaaa 273601 ctttttgtag gacattgatt attagaaacg gaaatatatg aggttatact taatgcttat 273661 cgtgatcgca atacaagtaa ttgtttatgg ttgtttgaaa accctagaaa agtggctaat 273721 ttcggataag aattacagat aggatctcta acataatata agttgttagg gtatttagct 273781 aatgttttta tatcgaaagc aggggataac agcggagaca gaaaacaggg aatagtgatc 273841 tcatctttcc atccgttcat cccactttta cgtccttgta aatagtacaa actgcgggta 273901 gtaatgcaag atttgatgat atacagggtg cttttgcatt gcaaccccct cccttaaaag 273961 acgctgggga gcaattttgt tctagaagtc ccctctttgt cgtcttccca aatccgactt 274021 gtgcggctgt gcggctgtgc acttcagggg gtgtccttgc cgtaatttcg aggagtcttt 274081 gtaagtgatt aattttctca aaaattcaac gtatgaaaag gtgatagttt cggcatctgc 274141 gatattcttt tggaccagtt agtgatgacg aaggccctta agattatgtt gggagccaaa 274201 ttttcgtagt tgcatacgta attttgaatt tgatttgctt ttttttcttt tttgccttgg 274261 ctttccgttg atgcggattc ttgagagttc taaaagttta tgtatacaaa caccgcattg 274321 aatgcttcgc ctcttaagca gacaactaga gtattgtaaa ccaggtaatg ggacctccga 274381 aaaatttcaa gcatttcagt aagagtaata aacacaaaaa ggagcagaaa gccctgatta 274441 ctcaagaaga tttctacctg gcagcgatcg actgtgaaga acaagcagac cgttggttgc 274501 tatcggacat aaagaaatgt ttgcggttct atctaaaggc tctagagcac tacgaaaatg 274561 gtctgactgc tttagattcc acgcaggaag ggaaatataa tatctattat aatgaaacaa 274621 ggcttttttt gcaaatttat acagattatc tggccaataa cggctacatt aatatcttgc 274681 aatacgtgaa aatggatgat atgcctgatc tttccaattt ggtgttatct ctgccacaga 274741 ttatccaacg gtttgaaatt gtttatgaga ctttcccaga acagagaact tgggatcttc 274801 aattcaatct attgacatgt tatttgactc tcatagagtc cctagacgac accgtttcgc 274861 ccaccgttgc aatggaaggt gcagacattt taactttgac aaacaagtat attgaaatct 274921 ttcaacacct ggttaattat ctgttacaag aactacaaaa ctggagtgaa aatgcagaac 274981 aagattccga tgacacagat acggaattgc aaagagatac tttggatgaa gacgcgatgc 275041 aagttaccag ggacggaagt ggtatccgaa ccaatggacc tgtacaacct ccagcagaag 275101 ttatggacgt ttctgaacaa gtgactccgt cttcacttac cgaagtactc gccaactctt 275161 taaagttcaa ccatgctttg atggaattgg ttattgagtc gaaaatatct attgaaaaaa 275221 atgtcgaaac gaaaatcttg aatcctattc agattaattt cttggaagat acaaccaata 275281 aattctattt acaactacgc gacattatag actccatttc cgccgccatt ccattagatt 275341 tgaaggaaat cggtttagcc aagactttaa ttgaaggttt gaacatcatt agctccggaa 275401 ccttcgagtc attgcaagat tttgttctgc aaaccgtctc ctttaccgat ctgcttgatg 275461 aaaaagatgt acagggtaag attgatcttt cgttgattag agttgatatc gttgaatttg 275521 ccattctatg tttaaacgat tattcttcag atgcatcttg gaaactctct gggttattga 275581 ccaaagttct tacagaggct agaactttat taacagacta tagaaatcaa atcttgtttc 275641 tgaaaaatca gacattgaac gaacaattga gtcacgtagt ttttcaactt tgtgatgtct 275701 tagtaaattc ctccgataat gaactgagaa ggtacgctat aaaagaatca actgaaaagt 275761 cacaaaaaac ccccggggga gcgcatactt taaacatatt gatgaaaaac gctaacgttt 275821 ttctgaataa tgctgtcgct atctcatcaa aacagtgcgg gttacaagaa acgattattg 275881 ataaactgaa gaggaactat atccataatc aagccaagga aagactactt ttcttacaga 275941 ggctggaaca gaagtcaaat gaggatgacg gtacttctgc ttcgcctacc gcaatgacgt 276001 tcgatatgcc accagaacac cctttttata gccactatcg gtagtgaaat tacgtacata 276061 tacataagta gaagataatt cgttgcgcat atgctacaag aacccttggt gaaacgaaat 276121 ttgatacaag taaatacatg caggaaacat acattacctc tgaaacaaag ccgagacggg 276181 gcccagcagt ctttttttag aaatcgcgtg gcttggtaac gcgataatga cgcgacacag 276241 ccattagtgt gaaatttgat tttcttggcc aaactaggta taatatttgt tacaaattat 276301 tgattttaat atatatctcg ggttcatttt ttacgtcggt actccaaagg atcagaacac 276361 ttacattttg aggcctaccg gaccttgcag tactgcttgt ttaaatacgc agtatacatt 276421 tcttcttctt cttctctctt ctttccttcc tcgaagagtc actaaattaa tactgggaag 276481 ccaaaccaaa aaaactatac aatgagtgat caaaataatc gatcgagaaa tgaatatcac 276541 tcaaaccgga agaatgaacc ttcctatgaa ctccaaaatg cacatagcgg gctatttcac 276601 tcttctaatg aagaattaac aaacaggaac caaagatata ccaatcaaaa tgccagcatg 276661 ggttcattca ctccagtcca atctttgcaa tttccagaac aatctcagca aacaaatatg 276721 ctttataacg gtgacgatgg caataataat actatcaatg ataacgaacg agacatatat 276781 ggaggttttg tcaaccacca tcgccagcgt cccccaccag caactgcaga atacaatgac 276841 gtttttaata cgaatagtca acagctaccg tcggaacatc aatacaataa cgtaccttca 276901 tatccacttc cttcgataaa tgtgattcaa accactccag aactcataca taacggctca 276961 cagactatgg ccacccccat cgaaaggccc ttctttaacg aaaacgacta ctattataat 277021 aacaggaact ctaggacgtc accgagtatt gcttctagta gcgatggtta tgcagatcag 277081 gaagctaggc ccattttgga gcaacccaac aataacatga atagcggtaa tattcctcaa 277141 taccatgacc aaccttttgg atacaacaat ggttaccatg gcctacaggc aaaagattac 277201 tatgacgatc cggagggtgg ttatattgat cagagaggag atgactatca gattaattca 277261 tatttgggta gaaacggtga aatggttgat ccttacgatt atgaaaacag tttaagacat 277321 atgactccta tggagcgtag agaatatctt catgatgata gcagacccgt aaacgatgga 277381 aaagaagaat tagacagtgt gaaaagcggt tactctcata gagacttggg ggaatatgac 277441 aaggatgatt tttcaaggga tgacgagtac gatgatctca acactattga taaattacag 277501 tttcaagcta atggtgtacc tgcatcatcc tcggtgtctt ctatcggatc taaagaatcc 277561 gacataatag taagcaatga taacttaacc gcaaatagag cactaaagag aagcggtact 277621 gaaattagga aattcaaact ttggaatggt aattttgttt tcgattctcc aatcagtaag 277681 acgctattgg accaatacgc tactacaaca gaaaatgcaa acactttacc aaatgagttt 277741 aagtttatga gatatcaagc agttacttgc gaacctaatc aacttgcaga gaagaatttc 277801 acggtgaggc agttgaagta tttaactcca agggaaacgg aattgatgct agtagtcaca 277861 atgtataatg aagaccatat cctgttagga agaactttga aaggtattat ggacaatgtc 277921 aaatatatgg tgaaaaaaaa aaattcaagc acttgggggc cggatgcatg gaaaaagatt 277981 gtcgtttgta tcatttcaga tggtagatcc aaaattaatg aacgctcgct agcattacta 278041 agttcgttag gttgttacca ggacgggttt gctaaggatg aaattaatga aaaaaaagtg 278101 gcaatgcatg tctacgaaca tacgacaatg atcaacatca caaatatttc ggaatcagag 278161 gtttcattag aatgcaatca aggtaccgtt ccaatacaac ttttgttttg tttgaaagag 278221 caaaatcaga aaaaaattaa ctcacataga tgggcatttg aaggctttgc agaattactg 278281 cgtcccaata tcgttacatt gttagatgct ggtaccatgc caggtaaaga ttctatttac 278341 cagttatgga gagagttcag gaatccaaat gttggtggcg catgtggtga aataagaact 278401 gatttgggta agagatttgt aaagcttttg aatcctttag ttgcatcaca gaatttcgaa 278461 tacaaaatgt ccaatatttt agacaaaaca accgagtcta actttggatt tattactgtt 278521 ctaccggggg cattctctgc gtataggttt gaagctgtga gaggccaacc attacagaag 278581 tacttttatg gtgaaattat ggaaaatgaa ggttttcatt ttttttcttc caatatgtat 278641 cttgctgaag atcgtatttt atgctttgaa gtggtcacaa aaaaaaattg taattggatt 278701 ttgaaatact gcagaagttc ttatgcttca acagatgtac cggagagggt ccctgaattt 278761 attcttcaga ggaggcgttg gttgaatggt tcattttttg ctagtgtata ttccttttgt 278821 catttttaca gagtctggag cagtggtcat aatattggta gaaaactcct tttgacggtt 278881 gaattttttt accttttctt caatacattg atttcatggt tttcattgag ttcatttttc 278941 ctagtcttta gaattctcac tgtttctatt gcactggcat accattcagc atttaatgtg 279001 ttgtccgtca tattcctgtg gctttatggg atttgtacct tatcaacatt catactgtca 279061 ttgggtaata aacctaaaag tactgagaaa ttttatgttc taacttgcgt catttttgcg 279121 gtgatgatga tttacatgat attctgcagt atattcatga gtgtcaaatc cttccaaaat 279181 atattgaaaa acgataccat cagctttgag ggtttgatta ccacagaagc tttcagggat 279241 attgttatct ctctgggctc cacttattgt ttgtacctaa tcagttcaat tatctatttg 279301 cagccatggc atatgttgac aagttttatt cagtatattt tattgagtcc ttcttacatc 279361 aatgttttga atatctatgc attttgtaat gtccacgact tatcatgggg tacaaagggt 279421 gcaatggcaa atccgctggg taagattaat actacagaag atggtacgtt caaaatggaa 279481 gttctggtct ctagttcaga gattcaagca aactacgata aatatttgaa agttttaaat 279541 gacttcgatc caaaatcaga atctcggcct actgagccat cttatgatga aaaaaagact 279601 ggctattatg caaacgttag atctctcgtg attatctttt gggtcatcac aaatttcatc 279661 atcgttgctg ttgtcttaga aaccggtggg attgcagatt atattgctat gaaatccata 279721 tcaactgatg acactttaga aactgcaaag aaggcggaaa ttcccttaat gaccagtaag 279781 gcctcaattt attttaatgt aattttatgg ttagttgcat tatcggcatt aataaggttc 279841 attggttgct caatatacat gatagtaagg ttttttaaaa aggttacatt tcgctaagta 279901 gattgattac ccctttgtta taaataagta tatgtgttta ctatcatata ataattaatt 279961 agttgtaagt atggtatttt tcaaagaaac atttagtatt atttttaaag ggtgccttta 280021 ccataaaacc aaaaaaaaat ggcttctgag agaaaaacat aaataattga taaaactgaa 280081 actcacaaca ccaactcttc cgctctaaac acccaaagct caaaaaacga catgtgcaca 280141 tctatatcca taaactttca aaaaagtggt tcattcgcaa attcatgaag tattatttaa 280201 tacacagtaa tctggcattt catactatca ttgctcaaat tatccgccgg acccttgaaa 280261 ctgtggcgct ttttaagacg catctccaaa aaaagaaaaa gaacaaaaga aaaaaagctg 280321 caaatatata tacaaaacag atttcacgtt tattgcttgg gagtaaggta acgatccgga 280381 agccttgaag aaatttgaat gtatccaact aactattgaa aatcattcgt gatgtgcaga 280441 ttcttgattt tcaaaggcaa acaaccgatt cggctatctc atcttttaac aagaccagct 280501 cattctatca taaaccaatc atttgatagc agattacggc tagacagaag aaggccaatg 280561 aatggtgatg gttttggtgt cgcttactat ccattggata ccgagttaag cgaggacggt 280621 ccatgccttt tcaaagctat tactcctgca tggaacaacc aaaatttgag tacattagca 280681 gaaaaaacta aatctgatct ggtctttgcg cacgtaagag cctctacata tggtgtccta 280741 tctgagacca attgccatcc gtttacatac cacagcttat gttttatgca taatggcggt 280801 atatctaatt tcaaaggaat caagagaaaa ttattgaatc atatcaaaga cgaatacctg 280861 aattttattc aagggagcac agactccgag tgcgcatttg cattattctt agacacttta 280921 gacaaattgg gttacgaccc aaagaagcag gacggcgatt tcggtaatgt tgcactaaga 280981 aaggcaatgt tacgaacgat tgactacatc agagattgga ctaaagaagc gaacaaggac 281041 gaggcacatg tggagccatc tctcttaaat tttgctgtaa ctgacggatc caccgttgtc 281101 gtttccaggt atataacttc aaagacggac gaggcagcat ctttgcattt cagttgtggt 281161 tccagctttg tagaaacttc accaggagaa tacagggtag aaaggttgga tagaaaccaa 281221 gatgtaatta tggttgcatc ggaacctttg actttcgaga gaggtgattg gactgcagta 281281 cccaccaaca gcatattgac cattaagaaa cagacaatat tactacaccc tattatcgat 281341 gagtactacc aagaagatcc gttataccta agaagttcaa ccctcgcaga aagcaagggg 281401 ctcatgggtt ctataccact agcaaaagcc gtagaaaaga acgttcctcc actagaaaga 281461 gagggccgta cgagacctcc aaccgctgtc gcacatatag catgagcaca cgctctagag 281521 gattgtacca ttgtcactac tagatataca tataaacaaa taagaagcat cgacacataa 281581 caacaacccc aacatcataa tttcataagt atttggttgg ttagtccata tggcgtctaa 281641 tcctcgaaat gagaaggtac ccgcctggtg tctatgacaa ccttccgggt aataaatgtt 281701 catttgaacc cattcatcca attgatatcc gggcaatcac ttccggaagc ggaaatttac 281761 aaatatccgg tgggtcctac aaggggacta aagaaaaaaa atacgtgaaa aacagcgatg 281821 cgatattttt tgtatcgtct tgttcgagtg tttcttacca cgatgaccgg gattttggcc 281881 ggtgaaaaaa aaaaaatgcg ctcccgtacg tcagtggctg ttgctgaaac gagacaattt 281941 ctcaattcgt ttgtttgtgt actgtatttg ttatctttac tatatatatg ttgttaagtt 282001 tcttttacca attagtgctc acttctctcg tcttttatta ggtgtgtgtg ttgtgcgtaa 282061 ttttcgtttc gctgattact ttatatagtg tagtttgttc ttgaatgtaa taaagacttc 282121 tgttttattt tgttttgtta tttagaaaca gtctatctgg tttaacttaa acgagtgagc 282181 ttaagataat ctgactacaa gaaaaccaag cttctattac tttgtttctt tctctttttt 282241 cttttttgaa taaagaattt tcctttaagg agtaacttaa gcatttagct gcacattaaa 282301 cacttttttt tttacttcta actcacacac ttttggaaga acatttattt tttcgacctt 282361 ctttcccaaa tacccagcgc tttataattg aaatatgaag ttctcttctg ttactgctat 282421 tactctagcc accgttgcca ccgttgccac tgctaagaag ggtgaacatg atttcactac 282481 cactttaact ttgtcatcgg acggtagttt aactactacc acctctactc ataccactca 282541 caagtatggt aagttcaaca agacttccaa gtccaagacc ccaaaccaca ctggtactca 282601 caagtacggt aagttcaaca agacctccaa gtctaagacc ccaaaccata ccggtactca 282661 caagtatggt aagttcaaca agacttccaa gtccaagact ccaaaccata ccggtactca 282721 caagtacggt aagttcaaca agacctccaa atccaagact ccaaaccaca ctggtactca 282781 caagtacggt aagttcaaca agacctccaa gtctaagacc ccaaaccata ccggtactca 282841 caagtatggt aagttcaaca aaaccaaaca tgacactacc acttatggtc ctggtgaaaa 282901 ggcccgtaag aacaatgccg cccctggtcc atctaatttc aactccataa aattgtttgg 282961 tgttaccgct ggtagtgctg ccgtagccgg tgccttatta ctattataat aagctttgaa 283021 ttggatttga gaaataaagg aagacctaat tttctccggt tttatgtttt ttaccccccc 283081 tacccccttc atcctgaagt agtaaattct ttttattata ctatttcgac tactatgtgt 283141 ttacgtgtgc ttgtgcaaaa gtgaaattta ttgtgattgt gttctttttc tctttttttt 283201 atacaaaaaa tggagaaagg aaattgggac ctacgattta aagaagtgtt atttcctatt 283261 tcaacgagtt aaatgaatgt gtgtgtttcg ttgacttgta aggatagaga aagatcatcc 283321 aacttttaat catggtttcc tttccttttt tatagcaatc gaatgtggaa ggaaaataga 283381 gcggagcttg ataattgtgt gtgtgaatgt cttgctttct ctttttcctt atttctacgc 283441 tatacaaaaa gtgtgctttt ttcttctatt tttttttctt taatgacttt gtgtgtttat 283501 taccctttaa ttaattacca aaaaaaaaat aaactacgtt tttaatttct aatttatcaa 283561 aatttctttt tttcacatat aactatatat ttatatgtca ccctattcaa gttcgttagt 283621 tttctttcaa cggtccaaaa tttgggatat cttgtgtgta ctttactttc tccactaacg 283681 ataagacatc tgctattagc ctatattggg cttaataaaa aaggtatctt cgtctagaat 283741 gatatatgta tacaatcaaa agtttaaagc taaatttttt attaacaagt tactttatca 283801 agtagtagtt aacttaatcg accgaattaa ttcaatagta atcaattcca atgcaccgaa 283861 gagtttgcca gtcgaactat ctaagtgata cttgtccatt tttcctcgaa gcgcaaaaga 283921 gattacatca ccattaacga attttcttct tttctttttt cttcaagagt tgatggggaa 283981 ggactaggaa ggaaacggtt cagatacgaa tttagtgatt aatcatattc tgctcaagaa 284041 gcgacttgta aggtaaggaa aacccgcatt cactgacgga ataaggaaca ggaccaacta 284101 taagcctcct tttacactca catcttcagg ctttattttg ttaagactga aacatttccc 284161 acttaattga agttacatcg ttattttata gaacgatctt tctattttgt tttttgttca 284221 cttgatatac cttcccttct acataacaaa ttaataaata tggataatgg tacagattct 284281 tccacgagca agttcgttcc cgaatataga cgaacaaact ttaagaataa aggcagattc 284341 tctgcagatg aacttcgtcg tcgtagagat acacaacagg tcgaattaag aaaagcaaaa 284401 agagatgaag ctttggccaa aagaagaaac tttattcccc caactgatgg cgctgattct 284461 gatgaagaag atgagagctc cgtttctgcg gaccaacaat tttacagcca gttgcagcaa 284521 gaactaccac aaatgactca gcaacttaac tctgatgata tgcaagagca attgagtgct 284581 actgttaagt ttagacaaat tttgtctaga gaacaccgcc ctccaattga tgtcgtcatt 284641 caagccggtg ttgttccaag attagtagaa tttatgcgtg aaaaccaacc tgaaatgtta 284701 caattggagg ctgcttgggc tttgactaac attgcatcag gtacatctgc tcaaacaaaa 284761 gtggttgttg atgctgacgc tgtacctctt ttcattcaac tattatatac cggctccgtt 284821 gaagttaaag aacaagccat ttgggcctta ggtaacgttg caggtgattc aactgactac 284881 agagactacg ttttacaatg taatgccatg gagccaattt tgggtctttt taactccaat 284941 aaaccatctt tgatcaggac cgctacgtgg actttatcca atttatgcag gggtaaaaaa 285001 ccacaaccag attggtcagt ggtctcacaa gcgttgccaa ccttagcgaa attaatctat 285061 tcgatggaca ctgaaacttt agttgatgct tgttgggcta tctcttatct atctgacgga 285121 ccacaagaag ctattcaagc agtgatcgat gttagaattc ctaaaagact tgttgaatta 285181 ctgagccatg aatcgacttt agtccagact cctgctttaa gagctgtagg taatatagtc 285241 actggtaatg acttacagac tcaggtcgtt ataaatgctg gtgtcttacc tgcgttaaga 285301 cttctgctaa gctctccaaa agaaaatatc aagaaagaag cgtgttggac catttccaat 285361 attacggctg gtaatactga acaaattcaa gcggtaattg acgcgaactt gattcctcca 285421 ttagttaaac ttttggaagt tgcagaatat aaaactaaaa aagaagcttg ttgggctatt 285481 tccaatgcct cttcaggtgg tttacaaaga ccagatatca taagatattt agtatctcaa 285541 gggtgtataa aaccattgtg tgatttgcta gaaattgctg acaacagaat aattgaagtt 285601 accttagatg ctcttgaaaa tattttaaag atgggtgaag ctgacaaaga agctcgtggt 285661 ttgaatatca atgaaaatgc cgattttatc gaaaaggctg gtggtatgga aaagattttc 285721 aactgtcaac aaaatgaaaa tgacaagatt tatgaaaaag catacaaaat cattgaaacc 285781 tactttggtg aagaagaaga cgccgtagac gaaactatgg ctccacaaaa tgccggtaat 285841 actttcggct ttggttctaa tgtcaaccaa caattcaatt ttaactaact gaatgtgaag 285901 aaaaagatca actaaataag tttattcaga taaatcttca ttatctgatc cattattttt 285961 aagtttttct tttaatgtat ataagaaatt ctaatctttt aattcgcaca atagtatttt 286021 catgtactag ttcgtacagt attctctttc tctggggttt ttccctttta tagaagttga 286081 cttgttctat agttgttata tatgtattgc tgggtttttt aatctatttt gcggaagacg 286141 ccaaaaataa gaaaaaaatt ggaaagacac aagaaaaaag taagaatatc cacagctgaa 286201 agatctaaca ggcgtatttt tattttcgaa gaaacgtcct aaaaggatct gattcagcac 286261 attgataata gcataggcat ttttatcttt cttttttgag ttcatgaatg aatgtaactt 286321 ctccaaaaga tgggaatcac agtttctcga agaaaaatag atttaataca aataaaccgc 286381 gattccacaa actaaatgag caggcgcaga gtataaattt accagaagac cgtgattcaa 286441 ttgtttcaag taatacaacg tcaattatga cagatgatgc atttgattac aatgagggca 286501 ttgcatcgcg taccaaaaat attaattctg atagtgatag aagcaatgat accataaaac 286561 aaaacaacta caataaaagg gagaccggat ataacccttt ctacaatgga tcagggatca 286621 atcagcgata tacacagttt cgaaaaagag agtttgaacc aacacttgca gaaaacaaag 286681 ccgaagagta catatcggac gaagataatg taaaaattga tgaagataat atagagaacg 286741 aactccagtt tacgccgaaa attaaagagg ctagtatact ccgatctagt ttactaggac 286801 aaagaaatgt tttaaatact cggaatccaa aatcaaaaga atcacacatt aaagtaaaac 286861 ccatcatcaa taacaagagc tcctcacaaa gaaaatctag tgcagcactt cggaaacaat 286921 taggaaaacc cctaccgctg ccgtatttga atagccctaa tagtgatagt acacccacat 286981 tacagagaaa agaagaagta ttcacagacg aagtgcttca aaaaaagaga gaattgattg 287041 agtctaaatg gcatagactt ctctttcatg acaaaaaaat ggtggaaaaa aagctagaaa 287101 gtttaagaga atacgaaagg aaaagaatgc ctccacgagg aactgatgtt tctagctctg 287161 agcaggacaa ttctttcaaa atatcgacgc caacaaaatc gtatgtttct ttggagcaaa 287221 aacccttacc aaatctctct gctatgaata actttaatga tgttaccgac aataaggaga 287281 aagaagaaac gaacaacaat atattaaagt tccaagcgca acgagatcca ttacaaatac 287341 tacagtctga gatcgaaatg catactaaga aacttgacac gataatagag ttactaaaag 287401 acgataccga ttcaaaggaa aaaaggaaag tagtgactaa tgacaacgca gcgcctgaac 287461 aaatggtcaa caaaggatgg cggaaaaacg tgatgatgat ctacaaaaaa tcaggaaata 287521 ttatgaaaaa gtatagggaa tatttcttat ggacaatttg tattttaata ttgttatatt 287581 gcaatatata tgtgtattat aggttttaaa ccatataaag gttagtacat gaagaagtgt 287641 gtacagttat ggcaataact gttctcttcc gttttaaaga gagtattatc acggtctgaa 287701 aattaagcaa aaaaagaaaa gcgtgcactt aaaaatcggt ggtggacaga ccgcatattc 287761 cataaacata gatggtacaa gggcattatg agtccttgaa tagaaaaaat gatgaaagaa 287821 tgaatgcaat tccgtattgc gacactggcg aagtgttcga ggctgacacg atagcgaatg 287881 tatggaaaag agaagataag gaatggttaa aaaggactca aagtgatcga agtggatacg 287941 agtatccacg actaggagaa tcaccatata tcaatatgac agacgacttc agaatggaaa 288001 agaaggtaat atgtcaagat atcttttggt catgtgatgg tacatcgttt gtttctgtgc 288061 ataatgattt tggcatcaga caatatttag tgccggagga aagtaatacg gacaagctaa 288121 acagaaacct ccttctacca tttacaaggt tttttagaaa ccagtctatt gtttcatgtg 288181 caatagaccc gttttacacg ctttataacg agaattccga caggttagct ggtgacagaa 288241 tcgtggttgg aggaaaaaac ttccctctac aactatactc tttgatggac gggcagtgta 288301 tcctcagcta tgacacgatg aacaaaataa atggagaata cgaaactgta tacagtgtga 288361 aaatcgatgt tgagtctcgt gtatacactg gctcatgccg taacaaagtg gcgatatacg 288421 acaagagcag acgagatgcc gtgtggatga accagagtac caaaaaagca agcaagggaa 288481 gacaaagcat tatatcttgc tttgaagagc aaccaatggg agggcaagct ctctcaagag 288541 gatctctatt gtgtggcagt tatgcgaatg aaatgtttca ggtagactgc cgtcatcaac 288601 gactagagag actgaactac acccgcacag ttgcaggtgg gattgtacaa atccttacaa 288661 gcgataacgg gcgttacgtg tacgttgtca gacgcaacag tgacgcgatt agtatttacg 288721 atcggcgaaa cctgcagcac gagcttaacg tattgcgcct accgtttcgg atccaccaca 288781 actctgcaaa gttgaaggca tatatagata cggcttacgg actaagtatg gggacgccgc 288841 agggaacaat attgaactgg ggtcgagacc ttgtggaatt tggaggtgtt ccctcacaca 288901 atagtgttga agacccacta atcacgtcta tcccgccaga gtcagagtgg cgcactaacc 288961 ttgattctac tattcctgcc acggtagtga agaattgtcc tggggatccc gaactgttcg 289021 ccctatctca tgggggcaca atttcattat gcaggttcgg cggctaaaaa cggcaaaccc 289081 gtattcgtgt atcacccggc cagctttctc cgatgaacgc gcacaagtaa gaagttaaat 289141 tgcatccccc agacaccacc tcttttgttc acttcttgcc tcatgccgtc aaaaaatttt 289201 tttcgcatcg aaaaaaatcc ccaaaagaaa agaaaaaagt tcttattttt atatagtgcc 289261 accatcggga aaaacttccc tgtaaagcat taacagagtc ttccatcccc gcttctgtcc 289321 tttatttgtt tcatagaagc tattaagcat catatactgc acacaggagc atgcatagtg 289381 tctgaagcct cttttgttct gtactgcaca taatatttca tagaaaaact aacggaaaga 289441 atctacaact catagtatct gtaaatccgt cctattgtca tatcacaatc acagactatg 289501 accactcaag aatcgatcaa acctttggta gatagaatcc tatcaaatcc cctgcagttc 289561 aatgctgcaa tgatctctaa caaatcgaat aataatgata cttccgccgc gccggaaaat 289621 agctcgtata ttgtgatagg aaaacagcat aataacaata gtaatagcac agctattgct 289681 gcaacggccg aatccaagca aataaaagaa aataacttga tagacaggcc aaacggaaag 289741 aaaaccaaca ctgttcctaa atctatggct gaagctttat tgttgtatac ttctaaaaat 289801 gataaagatg ctgcagatgc tactggtgcc aagaagtcag cggagctttc tacggagctt 289861 tctacggagc ctccttcctc ttcttcggaa gatgacaaag taggaaaaga ggaagaggaa 289921 gagggtgaaa tatttcatga ggcaagagac tatgtagaac cccgaaaagc tagtttgaag 289981 gaacgcgaca acgcagataa gggcgatggt gaagacatcg gcgaagacat cggtgaagac 290041 atcggtgaag acatcggtga agacattggt gaagacattg gtgaaaactt gggttctcca 290101 ttagcaacca ttgatgattc atctaatgag aatgaaaagg aaaaaagaaa ggaactgtct 290161 acaagcatta gcagtgatga cgaaatagaa gacgacgagg atgaggatga catggattat 290221 gattctagtg ctatggaaaa agagctccct gaagaagagg agaacgattc cagctccaaa 290281 atttctgaag gcgaaaaaaa gagtttatat caagatttaa tggaaaatag tacagtggaa 290341 gtaaatcggt acgaaccagt aaacaacacc aaagaaaatg gaaacaggaa tccaaaggga 290401 gaggaggagg aagaagagga agaagagctg aaacataaat ctaggtcaat cacccctccg 290461 gttacaatat caaatctatc aaacttttac caattcaatg aaaatatcaa tgatcgtggt 290521 tctttaaact ctactagaat tgttaaaaat tggggcgaca aattcaccaa tttgaagcct 290581 cgtggccttt tgaatcatgg tgttacttgt tacacaaatg ctgctgtaca ggctatgtta 290641 cacattcctt cgatacaaca ttatcttttt gatatactaa tggggaaata cgatagcacc 290701 atctcaaaaa attccgtttc ctatacttta gctgaaacaa gtaaaaaaat gtggttaccg 290761 gtctcaaaaa accctagaaa gaacgtttca gcttcctaca ttaatccaaa acatttgatt 290821 tccagattgg atgacattaa ttgtatgatg agcgaatggc agcaggaaga ttcacatgag 290881 tacttcatgt ctctgatgtc aagattacag gaagattctg ttcccaaggg tcataaactt 290941 atagaatcga taatatatga catattcggt ggtcttttaa agcagatcgt tacttgcaaa 291001 tcttgtggca gtatatctaa aacagaacaa ccattttacg atttatcgtt gcacttgaaa 291061 gggaagaaaa aacttgatcc aaattctgac ctgtcgagtg atagcattaa cggcacttca 291121 gccaccactt ctaccactac ctccaatgct gccacaaaac catctctttc atcctcttca 291181 tctgtcaatt taaacaatgg ctcaccattt gccgctgcca gtgatttaag ttcagccaac 291241 cgcagatttt ctattgaaaa atcaattaaa gatttcttca atcccgaatt aatcaaggtt 291301 gacaaggagc aaaagggtta cgtttgtgag aagtgtcaca agaccacgaa cgccgtgaag 291361 catagttcaa tattaagggc tcctgaaact ttacttgtgc atctgaaaaa attcagattc 291421 aatggcacgt cctcatcaaa aatgaagcaa gctgtttctt atcctatgtt tttagatttg 291481 acggaatatt gtgagagtaa agagctacct gtcaaatacc aactattaag cgtggtggtt 291541 catgagggcc gctccctttc ttcaggtcac tacattgccc actgcaagca accagacggt 291601 agctgggcca cttacgacga cgagtatatt aatataatat ctgaaaggga cgttttaaag 291661 gaacccaacg catattatct cctatacacg aggctaactc caaaatcggt tccattgcca 291721 ttggcgaaat ctgccatggc cactggtaat gttacctcta aatccaaaca ggaacaggct 291781 gttaacgaac caaataaccg cccattgaag attaatagca agaaaaataa cagaaaaaaa 291841 tggaaaaaaa ataaaaaaag gaagttcacc aaatgaaaaa actcgatatt cctggatttt 291901 cctcttttca taggcatttt tattagcatt tcatttttat tataccaaat caatatatac 291961 atataaatat ccggtcttta ttgacttata aaacaactct cagtatacag agttggagaa 292021 gcgtttactc agaatagctt cagtactacc gagctttgct aacataacgg gagaaagaga 292081 atttaaaact tatatacata tttacagaat agatcagtag aaagaagaag gaaggtctgt 292141 tgaaaatttc tcgaaattga cggtactttt ttgtcttttc actacttaca gatcaaggta 292201 caaccttaat acccatactt tttgcaacgc caactattga tttaacaata ccttccatct 292261 ccaataaact atgcctttca tcactctttt ttatcttggc tatttcgtaa acgtgcttca 292321 gcgataactc tcctaaagca cgggttggtc ccttggcagg tgcactgcct aacattgtcc 292381 ccacattcgg ttgtccatgt cccttgtcca ttttaagagc ttttagcagc aaatatccgg 292441 ttggtggaga tttcatttca aacgtaaatg ttctatcagg ttttattgtg attaatactg 292501 gaaccggtac acctggctga tagtttgctg atcttgcatt aaattcctta caaaagtcaa 292561 tggcttttat acccttggag cccaatgcgg gccccacggg aggtgatggt gccgcttggc 292621 ctgctcctac tattagcttt actatcacgt tttttgctgc ctgtgacatt atggagacta 292681 atagttcctc tatggtattc gagagttcga aagtacaaca aacagaaata aatacagaag 292741 gttacgctgt cgatttgaat gttcacgctt tttttccttc ttatgagttg tagatttact 292801 gcactttcta aagcttcttt gctgtgaaat tttagaaaag ggaattgtcg ccttggtaag 292861 acaattaatg ttacccgctt cattattatt aattagtggc gcgatatttt aacgaacttt 292921 tccattaatt attatcatac taagctttta catttttctg ataaaatagt agattatgaa 292981 caggaggtca atctatttag gcttctatag aacggtaaaa tatgaaatta gtttaacaga 293041 agtaaatatg acattgtatt ttaacatata ctcaaatagg ataaaaaaag gttatataca 293101 aatgcttgga aaagaaataa aagtggggac gcttatttat tgattatttt gctttttctt 293161 tttcttttct aggcctgcaa tatgtgcttc actttgatcc acttgtgtgt gatgatggtc 293221 ttctcctcta accactttga acgataatcc atcttcaacc aagtggcaca tatcaatgct 293281 acggatccaa ggatcttcca tgatttcttc gatatttcct ctgcatgcgg gcgccaaatc 293341 aatcatacgt ccaacaatat gctgagtctc ttctggtaat gagtgcaaca atctttgtgg 293401 cccgatatta acattattag gatctgatac attattggaa gagctttcgg gttttttctt 293461 ttctgttgag tgcgattcat cgtaggaagg tggatcagga gttcttgtaa ccaagctact 293521 taaggagtcg caatcacgtc cggaacaaaa tagtttgaat gaattgtccc ttaatttcgg 293581 aattttccat ggaaatttct tcagtatcat acatgcaaaa atgattgcag aagaccaaat 293641 atctacggga cgtgggtcat acttcgcaaa tatacagact tcaggtgcta aatatggatc 293701 acttccaaca attccacttg cttccacaag attttttgag aatggatatg aaaataccac 293761 agcagcacca aaatcgatta attttacaat acctttttcg tttataacac aattatctag 293821 ctttagatct ctatgagcta agccgatact atgcaaatat tgtacaccag taagtatttg 293881 tttgaagcaa caacaaatct cttcatagga cattttatta ctcattacaa tagcaaataa 293941 atcgtattca caatattcca taacttggag aattctatca ttttcataca cgatttcaat 294001 tgtttcaatg atattgggat gattcaaagt tgtaccaata cagtattctg atgtaatttt 294061 cttgacataa tctcttttgg attcattttc aaatttagtt ctaaactcct tcactgcaaa 294121 tattttgtta tctgaaattc tttgagctaa tttgacagaa cctcctgctc cagcgcctaa 294181 atcggcaccg gttttgatgt acctttttga gaacggaatt cctgaaccgc cgtgactatg 294241 agaataaata gtatctccat ttccgttata actagtggaa tatgagttat tccctgcggc 294301 aaaatgagac gatgaatgag agtgtgacgg aacggcaatt ccgctagaaa gaggtgatcc 294361 gttcgggatc acgttgttac tattcgagga aaggttactg ttagaacttt ttttgaagaa 294421 cctctttaaa tcaccgatgg aagaatgttg tgaccttgga acactttgac ttggaggtaa 294481 gtggtcatgt acagatgagg gggaaccgta aaagttatca gtataggaac cagttggctg 294541 tcttgatgca gaatatatgc tgctttgtct tgcgcggata ggcttcggga taggcgtcga 294601 accattggta acattgggat tcttaatgtt tggagaagga ccattggaat tggcagaaaa 294661 agacatgcct gcagagttag aatttgaaga ttcttttgag tttttggaaa agaaaaaatt 294721 cccaagctgt gaagagaatg aacctgaacg ggatatagat cttgattgag tggcatttgc 294781 attattacta tccatcgatg ctttttggag tttttgtttg gagataacaa aacgtggttc 294841 cacgctatct acttttgggg aggatataac atttgaatcg attgcagaaa tattattggg 294901 cataccgcct gcatatgttt cgagccacga agaagacaaa gaggagctgt tgctattcga 294961 gctattgtta tctttgttag aatttggcac ggagtaaggt atacttgatg ataaagaagg 295021 aatggccctt cctgaagtat gtgacgtggt agataatcta cttgtgattc tgttctgtgc 295081 agcaaaagaa ccaccatgtg aggaaagtcc tgcagtacct tgatcgttta ttaaggatcc 295141 aaatctatct ctactttgtg cacttgtgcc gtagaatgat gcagtgtgag caaagtttgc 295201 attaaggaag ctggaggaaa actgattcct atcgtcgaga gaggaaccgg ctgttgatga 295261 tgaatcttcc tctgagtata tttgagtaac agttgtgaca ctgccaggaa ctggcacgtt 295321 agccctatta cgatcactac tgctgctatt actcacgcta ccaatatgac tactactctt 295381 attcctagag tgaaggtcaa gcgattgtga ctcgggcgtc gtggtcaacg tatcagcaga 295441 agttctcggt gatgagttcg aagtttcatt ttttcgtttt tcctgtagca atcgagttaa 295501 tgaagacata atgtttcgta gagctttcct tttttgtttg aatgggtatg agctgttgga 295561 aaatcagaaa taggaaagag ttagacaaaa gtattaatga gttctggtac aagccaacta 295621 gtttgtatgg ggttgaaaat gacgcaaagg aacgagaact cctgtttatt attctttcaa 295681 taacaaaagc aagattttta gtcactgccg attgttgcca ctaggtacgc cactgactaa 295741 tccgtactaa ctctatacaa ctaaaggcgg cccatattct gagataagct ataagggtag 295801 gaattgtggg atgcgtcatt gataacgaaa aaattccgta atagatgatc agtcagattg 295861 agaatgagat gtttcgcaca agtgatgaat tatatctatc tatgctgtat attttaataa 295921 cattcctatt ttattgtaca aaatgcgcga ctattccgtt tattgcttgt caagcatctg 295981 ttggtgttcc tcgtacagct tttcgtgcat gtcacgtaac tccttgtagg catgagttaa 296041 tgcttctatg ttggtcttaa gttctgtaat ttcctcatct ttagcggcat tgctgtctaa 296101 agatgaagtg gcgtcgattt tattgtcaat cacttttaca ttgcttgaca ccttaccgat 296161 atgtgaaaat atcgattctt gcgttttgac ctgctccaaa taggcattaa agtcgttaag 296221 tggtaatgcg aggttaggat ctgtctctgc ttctggttct cctatctgat accaaatatc 296281 gtgtaaatgg cctttgtttt taccatcaaa gataactctt tgtaagtttg gtatcttcat 296341 aaaattgtga ccattattat tactaggttg tttgcctttg gattctcctt caaaaagtaa 296401 atttccacgt tcgagtctgt aagggttggt taagagattg gtcacttctc caactgaatc 296461 ctgtgatgta gttaaagttt ggatagttct aatgatttgt tttgagtaaa tttccgcaat 296521 agaaactttc ccctccgtat caccgatcaa taataatgta ccatccattg atatttctag 296581 gcatgacaca tttgaattta ggacattctc acagacaagt tggcccattg catatagtgc 296641 atccaaatct tcattttcgc cgccagttag tgagttacgt tgcactaggg aaaaaaccct 296701 acctttttga actgtgttta ctccggcgga ctgtagcaga ttaacgatag cattaccctt 296761 tagtttataa aataaattca atgaaaaaca accttccgca gtaccaatat agcatgctct 296821 gtcagcagga tccagtacaa tggatttgat agaataagga gttgtaaatg tcgcaagcaa 296881 tactggggtc ttaccaatac taacgtcatt ttcgtttgcc ttctgcttct ttttgctgcc 296941 tattaaactc aaatcatagc atctaatggt agcatcttga gatactgtga agagtttcgt 297001 atcagtacat gataaaaatt ttccttgact agaagaaact tggaaatctg tcacgggtag 297061 agtatgatcg tgaaggatac ataaaggctt aggatcatca ttggacgctg ataccaagtc 297121 aacagtttgc catataataa ctctcgaatc gttaccagaa gtaataatat acttgccgtt 297181 taaaatggac ttaatcttgg tgatactttg gtaatgagcc ataggcttca cgttcaataa 297241 aatccctgaa tttaactccc atatgtacaa tttacccgat tcggtggagc caagtaaaag 297301 gtacggaaga ttgaagtctg gtaaattatg attgacacct tgaattctat catactgcac 297361 accatcattt tcaactactt ccagacattt taggatttca ggtaatggta agcgctgttc 297421 aacagattct cttttgaaag aacctgacag attgtagaca ttgattaatg ctttttgtgc 297481 ttgagcaata aaaaggtatt tatttcctac ttgaacacag ctatttcttg attgagtgga 297541 gcattgcctc aaatttatct gttcaaatga gtgtacagaa gctattgttc ctgaggtatt 297601 tgttgtaaaa ataacttgct catccatttt atcgtccctt gaaagatcct gttttatgaa 297661 tattgaacaa tcaatcttaa cgcatatgcc cttgtcagag ccgtccttcg aataagcata 297721 tttggaatgg gcatcgattt aaaattttca tttagtggga tgtaaaaaaa aattttagtt 297781 cgcgcgtaca gtttttcaac atttgccata tgatgtagaa tggcgctatc aaatcatcac 297841 tcttattaca ggtgaatcgc gcgctaacac ttcaattaca gacacatact cctgaatggg 297901 tgctttcaaa tcccctctcc cccaagatca agtcctattt caacttctcc tctcaaaaac 297961 cctctatgtg acgctgtgta ttctttgttg tagttatgct ccacgataca gtggctgctc 298021 atgagctttc ctaggagctc agcacgtaaa tgtatagcgt acatgctata agcgtggcag 298081 ttattataat agttcacacg gtatcttacc gtattaattt atcaaagttt gcagttatcc 298141 attctgtgcc cgcgtttctt ttcagtttat agacgcgatc gaatgtgcct taaaaatttg 298201 gaagaagaga gagaaggatg cataagtaat agaacattac gagaaaatag tttacagaaa 298261 caactggctg ccctgaaagg cttttttgga gaggaacaga aacaaagaac aaaaattttt 298321 agaaaaaaaa agaaatgcct ttgaatatta ttgggacggc tctcctagac gggactgaca 298381 agattcctta ctatcaaaca atcaaaaagg tggcacctta tgtgctagcg actggtgcca 298441 ttaaatattg gtcgagaggg ccatcaaata catgggaaag aaagttgcac ggtaaagttt 298501 acttggttac tggcgctacc tctcaaggaa tgggaacatc cgtggcttat aaaatggcag 298561 agttaggtgc acaattaatc atcttgacta gggaagtaga tgaatgggtt actgaatggt 298621 gcgaagaatt acgtgaaaag acaaagaacg agttgatttt tgtagaaaaa tgtgatttga 298681 gcaatttgtg ggagattcgt aagtttgcca caagttggtt agacaattcg ccacctagaa 298741 gattagatgg cgttattgtc atgtccggtg atatggaacc atggggtatc ccgaaaatat 298801 ctttgccaca gaggagatca tctaaggatg ggctggaatt gcaaattgct acaaactatg 298861 tagcaatttt ccatctttta aacttattac agcctagttt caaggctcaa ccgcctgata 298921 gagatgtaag aataattctt gccacctgct ggttacaagt tgttggtgat attaatatag 298981 aagatccgtt gtggcaaaat gccaaataca aaagcgcctt gaagtttttc gcaagcagca 299041 agctacaatt gggattgagt atgatggaat tgcaaagaag acttaccgaa gacataaaaa 299101 accaaaagac gaatggcgct gaaagaacag gaaaaaatgt taccattact atggttcaac 299161 ctggaactat gagatcaaat agcctacgcc gcgtcattag taatggttcg gtggtattgt 299221 taataatact ttactgtatt ctgttgtacc ccatattgtg gctgtttacc aagagtggtc 299281 gtcgtggtga tcaaagtttc ttgtacgctt taatgacacc ggaattggag gaagtaaact 299341 taaaagacac gaaggttaag tatatctcag actgttcaat tgtgaaattt gctcgtaaag 299401 aatttgatga cgaggaatta cagaagaaac tatttgataa tacggaaaga gatattttac 299461 aattggaaaa gaaagtcgcg gcaaagagaa atgccaataa gaccgggaat caaaattcta 299521 aaaagaagag tcagaacaag agtagaaaag atgattagaa atgagaacgt aaatatatgt 299581 gtagatttct ttttttctta tttatgatat cggtatatgt aattatttat ttactttttc 299641 tgcctccttg atattaaagt attacacact ttgacttctt tttcttcttg tcgtttctcg 299701 tctttggttt agcttgcttg ttgtgatgat tatttgaggc aattttacta cctttgcttt 299761 ttgattgctc gtgaattttg tctttttgtc ccttttttgt gggtttgata ttgagagctt 299821 ccttctcctg ctgtaagctt cctttcggaa gagtactatc tgtactatta ttatggtgtg 299881 gttgctgttt ttgttctcga atatttttat ctccattggt gttggttgtt gcagtcgtta 299941 attcatcagt tagagtatga tttgctgatt tttggttagg ggattctggt tcgtagatag 300001 cgtacctcac cgcctgttca aagacttccc ggacacctgc ttgggtagca gctgaacatt 300061 cggtatagcc cataaaccca catctttgta cgagttcatc tatttcctct tgagacacgt 300121 aatcggagtt tgcttcctgc aattttttct gagttgccgg atcatctctt aggtcacttt 300181 tggtgcctac caatagaatt ggatacttcc ctaatttagt ataaagagag gtaccttcaa 300241 tattggaagt ctgcttcagt tcaggtagcc atttttctgt gacattggca aaactagcat 300301 gttcgcttac tgagaaacat attaaaaaaa tatctgtttg gggataacat aacggtctta 300361 aacgatcgta atcttcctgt cctgcagtgt cccataaatt gattttatat agttttctgt 300421 ccgtacttgg tgaagaactg gcagatgaaa gtgaacctct tttatcatta ccattgtcaa 300481 gctctagggg gctactcgca gttccgttcg ggatagctat cgtagtagaa taattatcaa 300541 aaaccgttgg aacatagtct gttgggaacg aattggtagt atatgatatt agaagtgacg 300601 ttttacctac tgcaccatca ccaattatca cacatttaat agacctcatc agacttatta 300661 gtatactata ttgtatttaa taaatatttc ggcgtgtgct ttgtgggtgc cacctgtctt 300721 gtatttccta tccaactgaa tattctggat attgtcttgt gcaatagacc ggaaaaaaaa 300781 aagtgaatgt tccaacgctt tggaatacaa tgatgggtca aggatcgtgc ttttgttcgt 300841 tggtggatcg gccgtacgtg tttagtgagg gtactattta aacttacttt aaatagcaaa 300901 ataggaaaag ctacgagaaa ctgaaaagta aaaaaaaaaa aaaaaaataa aaaaaaaaga 300961 aaaaaaaagg agaaacatga ttgccagtac tcgcaagaac taagatagag agaaaaagga 301021 cgatatatca agaaataaaa gggaaggtaa ttcaagtaag cactgcttag ctgtctgcat 301081 aggagccttc tgcaattact catctcatcg tattcgtcat aacccgttac gtaactgatt 301141 tgaccaagaa gcgtaatgaa aattttgagc ggacgccgaa acgttgtttt ttttttgctt 301201 tagtccagat aataaccttt tataattttc tttttaggga ggaagaccgg tctaagctct 301261 tagaggttct cgcataccca agtaaaagct aagaccgaag caaacacgca ggataatttt 301321 ccggtttact ctcactgcag ctttagtata gatgcagatc tggtattgag agaggggggc 301381 cggaacgaaa agattcaggg gagagaaagg cccgggcgtc ggggaacaaa accacttttg 301441 cacaccttaa ttttttagct actctgtttc tccgggcttg tatggcacat aaataaaatt 301501 ctgctacttt ccattatctg gtcatcactt accgatgtgg agagccttgc ccttgaaaaa 301561 taagataaga cctccgatta gggtatttga aattaaccgc tgtagaatga aataaggacg 301621 cttgtttgac attttttagt tgctttctct atctaccacc atttgcatct tgatttatgt 301681 cttgtttgag gagatttcgg ataaatattc ttcgagggga aaatgtcgta aaaataaaaa 301741 caataaagaa acaaaacgat taaaagaaaa actcaaccat cctcaaaagt cctcctcttt 301801 tttttcacgt gctgcgctga tgtaagcagc aggacatggc aggaagaaaa tcggagaatt 301861 gtggccgcga cacctgacaa acaatcctca ggcaaatgta aaattgtaca tgaaaggctg 301921 cgtagtcaat gtcttagaag gccggcccgc atgatccaga agcagaccat aaaaaaaata 301981 aaaattcgcg gtctggcagc aggcataaga tgcatagcgt tatcctaaat gacatcacga 302041 tgataaatcc tccgccgcat gatgcttttg atttgcctaa gggcctgcca tcgtgctggc 302101 tcaaactatt gagggtcaac ataccttgaa aatccaagta aaaggatgga tatcgttata 302161 ctaaaagcaa cacagaaaag gtccacgtca gttccacaca ataacattta cgtagtgttc 302221 acgcgaagca gttacatctc aactaacata attgctggtg agcctacaac actgcatgcg 302281 taaacgtcaa cgggattacg ttagtatttt tggccgccgg taaattctct tgtttttttt 302341 tcttgatttc acttcttttc atgttccttt ggaataatct aattcctcat gattaaatga 302401 gactgttttt tgtttccgta acatccatac ctttcctgta taatattctt gctgtaaagt 302461 ttgttttttt tatgaaaaaa acattttctt ttcttgagat gaggcgccgc gagcctttct 302521 cccatgggca gtggtaaatt ttccaaatca atgcagctct ttgaaataca acagcatttt 302581 tcatacattt taagcaattt ctagtttgta gatattgtta gattagtttt tgaacattgt 302641 tttgataact gaaaataaaa cagcaaacaa actacaaaaa tggtcgcttt aatctctaag 302701 aaaagaaagc tagtcgctga cggtgtcttc tacgctgaat tgaacgaatt cttcaccaga 302761 gaattagctg aagaaggtta ctccggtgtt gaagtccgtg tcactccaac caagaccgaa 302821 gttatcatca gagctaccag aactcaagat gttttgggtg aaaacggtag aagaatcaac 302881 gaattaactt tgttggttca aaagagattc aagtacgctc caggtactat tgtcttatat 302941 gctgaaagag ttcaagaccg tggtttgtcc gctgtcgctc aagctgaatc tatgaaattc 303001 aaattgttga acggtttggc tatcagaaga gctgcttacg gtgtcgtcag atacgttatg 303061 gaatctggtg ctaagggttg tgaagttgtt gtttccggta aactaagagc tgccagagct 303121 aaggctatga aatttgctga cggtttcttg attcactctg gtcaaccagt caacgacttc 303181 attgacactg ctactagaca cgtcttgatg agacaaggtg ttttgggtat caaggttaag 303241 attatgagag acccagctaa gagcagaact ggtccaaagg ctttgccaga tgctgtcacc 303301 atcattgaac caaaagaaga agaaccaatt cttgctccat ctgtcaagga ctacagacca 303361 gctgaagaaa ctgaagctca agctgaacca gttgaagctt agatttaatt attaaataca 303421 taaataaact ataagtacaa taatttcttc tattctagtg cacttaattg ttgcggtttc 303481 ttgcatattg ccgtgtttag tcaggagggt gcacgttgaa gcagtgcgtt gaaactagtt 303541 gttatttaca gaatcacaat attatataat caaaagaaaa gttttgtaca acacaactgt 303601 gaatataggt taagaagtga gtagcagttc atctttctca gcttacagga cgatttctcg 303661 gatatgaatg agttcgctat cgttttcacc acttgtatac gccgcctgta acacccctaa 303721 tgggcttatc tcccaactgt acccatggcg ctcttttttg ctcttttaaa tgtgcttcat 303781 aagcaagtct tcgtttcgta acactctttg ttctcagaat acatctgaca tgtatgtaag 303841 gatgacttat gattccgatt cttgtccttg ccttgaattc aacacgtttt ctccaaaacc 303901 cgtcactccc tgtccaaatc tgagagatat ataagtcctc tggtttcaaa cctaattttt 303961 ggccatcttt tacacctttt tgaagtagtt ctgctacttc gcgagcaatt ttcttattag 304021 aaaagtgaca ctgagatata gctttcataa cgtcgaggcc tcccaataac ctcaacaaaa 304081 gtgtagcctt tttcatcgac gatttaattc tatatgactg agcatatacg gaaggttcta 304141 gtacttcaat ttctcttttt gttaacttta gcttgtaacg ttcgctagaa tttggtaact 304201 ttacaatagt atctttcttg taaaacccac cattaatttt acaattagct tcatatattt 304261 cccttttcaa aggagataat aagctctgtg atgctaattg ttccggttgc tgcaacgata 304321 tgatatgttg ctgtagtagt ttatcgtttt ctatggttat tgaatcccta ttaacttcag 304381 gagcctctcc agaagaatca gaagcaatcg ctaacctatt agagaagctg cctgcatctt 304441 catcccccct gttttttcct tcctttggtt tattttctgt aatgcttccg aatagtgatc 304501 ctcctgaatt attaagactt attggcgtta catgaatcca acgtctactt acagaagaaa 304561 gtagagccct agaaatgaca ccgacctgag atattcttgc cgtgtggaag ttcattttct 304621 ttaataaaaa agatagggtg aggtgaggtt ctctgacttg ctatgcggct cctaatggcg 304681 tatgttaaaa tgccttccag attggatagt tgacttttat tcaaaatccc gagtacagtg 304741 aaggcttagt taccccgccc acagaagatt aatagaatat catgagtact gttcaagcag 304801 caagcaggag aaaagactga aagagtttcg tataatttag tatttattta tttaggagaa 304861 ctaaaatatt ttctttatac acaaagaaca aagttttctt tttttttcat tgcagaatgg 304921 tatcattgtt ttttatgcct tttaaaaggc cttgtcgttc ttcactattg gcaataaaga 304981 tgtttttatg atttttaata gtagtgttat tcagcaagag ctgattttgc ttaattagta 305041 aacatcatac taatagactg aagtcatcgt catataattt ccctcaagaa cccttgtgaa 305101 ttgttctgaa ctgtatttct ctcatcatga gagatgtcat tatctaaacc acgtccgagt 305161 cgtatcgaat ttgaagataa agtagaaaag ccaccttgag tagatgaacc caatgacgaa 305221 tatgtaaatg aagagccata ggaaaatctg ttttcctggt ccatgaaatt actccgcata 305281 ttttgaaagg agccattcat tgcggtaaca ttccttggtg gtggcactgg aggaggattt 305341 cctcttgcct taaaattgaa ttcgttgctg aacggattat tagcagaagc agtctcggtg 305401 tttcgttgct gtgatcccga gtcttgagct tgaagtgacg cctcttttgc ttgggcagtt 305461 gttgggaatc ccgttctgcg cccaatctcg tgacagaagg aatcgttttc cttgaaatgc 305521 ctctttgcct tcctttttct aaccagcatg aaccaaacta ctagtacaca tataagaata 305581 ccaccgacgc ttcctaccac acttccaaca atggtaccag tatttgtctt tgaagtgcct 305641 tggtttttgt tattatccaa actgccatca agccagtgct gatagaaaga catgtcagct 305701 gtgatcgtcg aagatggagc ggaaaatgag gttacctcac tttttgcaac tgctatggtc 305761 gtaggtaatc ccgtcacgaa cgttgtagag gagtcagtaa tatcatatgt ttgggtatag 305821 aaataataaa tagtttttga atcttcggag cttgaaatgg ctaccgtatt gaagacctga 305881 ctggatgttg gtatgggaga cgtagaaatc gtactagtgc tgggtgtttg agtggtgggt 305941 ggtatactgc tgctagtagt agattgtaag gactgaaaag tatacgtgct tgagtaagca 306001 cttgttgtat catctgatga tgatgatgat gaaggacggt ttgaaggtac tttactgctg 306061 gatgagctaa cagaacttga cgttggcacg gaaatcgtgc ttatggaaac tgtcgaagat 306121 gaagctgatg gactgagttt cgatgatttg cttatggttg aaaaatcgtt cgtcgatgaa 306181 agcgatgaac tgtaaaacga tgtggaagta ttccgactgg aacttgggaa tgtggtatct 306241 ttatttgata tcgtagaagg agaagaaatt gttgagaacc aactagaaga gagttctgaa 306301 gtggtactaa tttgaaatga agttgcagat atggaagaca agtatgtgta actaggggat 306361 attacggtgg gtgttgatgg tgagaaaata gaagatctgc tgtcgaacga aaacaattta 306421 gtgtctgaat atgatgaaga tagtgataat gacaacgagg acgataccag taacgaagat 306481 ggtgatgata acgacgacca tgatgatgac agcgatgtag ctgatgacga taacgttggt 306541 gttgttgatg ttaacgatga ccattccgac gttattgacg acgatgatga cattggtgac 306601 gtcgatgaga aaatggacat ggatggtgta attattgagt atgaggaggt agctgggtca 306661 tattgggaac tatacgtatc ttgctcgctc gatgaactgc tgtcggtaga tgatactaaa 306721 gtacttgtcg aagatacatc aatggatgta tgcaaagtct catcatatgt taagcttgta 306781 gaataatatg taggagtagc tgtactagac acgggcggta atgaggtcag acttccttgt 306841 tggggtacta aagttgaagt agatgcgaag acaacatccg ttgatcgtga attcagactg 306901 ctacttggtt cactgaatga cagggatatc gtatcagatt ctccaagggt ggtccttccg 306961 atggtactat tggagttcat acgatggcca aaataattac tctatccagc ttttctttta 307021 gatttccttc agatatcgac ggatggggat tgaaatacta aatgtgtgtc ttaagcgaaa 307081 gtgtgccaac aaccagtcca aaaaacggat cagtagtgtt tcggtacctg gtgagtagtt 307141 taggatttta tgagtgtacg gcgattatca gtgtattact aatatgcgaa ccgctcctaa 307201 agatcttgtt tacctcattt ctttcttctt tttttttttt ttttccgtgc gttctccccg 307261 tgccttgata agcaataatg gaaaaaataa aaatagcagc aattggttat acaatgtata 307321 tataaaacat gaatgattga ataatttaca agcgaaataa tcgcattata tacgtggcac 307381 ctacagtcag ttcacgctga ttagtcaaac ttcactttct taccttgtga tgggacaata 307441 gctgcagaac ctctctgagc agtggctaaa gctacactgc tcttagttcg gttattggaa 307501 tctacaggtg gacgtctgtt ggcgttggac cgcttgtatt cgggtttgct gccgttatcc 307561 tgtcccgcac gatcgtatcc tttgttgtta gagatatcaa atgatgagga attgtttctg 307621 gatacatttt caaccttctt acgaacttgt cttttacttc tatcttcacc gtattccatt 307681 cgcaatggcc ttccggcaat ttttctacaa cttttatcct ttaatgcatt agtagatcct 307741 tcttcattct tgaagtcgat aaatgcgaat cctttacatt taccactatc ttcgaatgtt 307801 gccatgcgga ttttcacgat atcaccacaa tgttggaagt gttttcttaa cagatcatct 307861 gtgacatcga atgacaaatt accgacaaat agaatccttg acggtggatt tttggacatg 307921 gcaactaaat cgtccttgtc tggcctacct gaataatttt cggagtcctt gattagcata 307981 ttccttccgt ttaaatgaga ttcagataat tctaagaccg ctttcatctg ctcgacgttc 308041 ttgaaaaaca tgtagcaaaa tcccttattt ttcatggcgt tagagttctt ggcagcaaca 308101 cgaggcatgg ataacctggt tatgtcttgt tcggtgactc tgctcttttc atcttcgttg 308161 tcttttgttt tagcaataaa aaatcttact aaatcgtcct ttgtggtgtc gaaggataag 308221 ttaccaatcc aaacaccata tttattttca tctttcttct tcttttttac aacctcgcca 308281 gattcatctc ctgttggagt gttgattgta gattcttcac cctgggcgtc tttctcagaa 308341 gcaccagact ttttcttttc agcatcttct ttgtattcct cgattgactt agggtcgata 308401 ttgtacttcg cattcaactc ctctagagta actttacctc ttctcaagag acgtttctgt 308461 ttttttgata ggggaatgga gcttttcagg tcaatctcaa tttcatcttc agcttttctc 308521 ttttttgttg gatcgagtaa agccttcttg acttgttcct cgttatcctt ttttgtaaca 308581 gcatcttctt tcgacagttc tgtttctgac attctatctc aaattataga aagttgttgg 308641 gtttaggtaa tgttctgtgg ggaaaaggat ttctctttgt tgtatggtta aatttatcat 308701 ctatgctcat cgcaattttt tctttcagac tgaaaaattt caggtttttg catttcaacg 308761 ggaaacgtga ctcctacaga attttctgag caaaggcgta caagcgaaat acaaagacaa 308821 gcatgtgctt tcggcaaaag tgcgatccta catcagagtt tacatacaac atggtattgt 308881 tattaataca taattaggtt ttacatagtt aggtatggcg agtacgtcat atatttaggt 308941 attctcctga ttgttttcac ttcaaaagct gggccaactt tttaaagaac cctccattct 309001 tagcagggtt cttttggaca cctttatttg gtgtttcttt cgtgccctta ggtttcgaag 309061 gtctagtagc tttcttagct tcgatttttt ttgcggcagc ggtaggagcg ccctgtttcg 309121 tctcgtaagt ttgagtctca gtcgcaacct tgccggttgg tttcacagaa gtctctttag 309181 catggcttgt aattgagctt acaggtactt tttcttccgg tttttcaaat ttagcggatt 309241 tacttaatgg ttccttattt tgatcttctg aagcttcagc gtctgcactt gtactggtgt 309301 ccttaccgcc gcctttatct tcgtcctctt cctcttcttc cttttcaaga tcttcggccg 309361 atagttcata taatctagac tcagaagatt gcgtcttacc caaaccgtcc gtaacatatc 309421 cttcactctt aactagatta actttggggt gattctcttc atacggcttg attgcttttt 309481 cctcgtttac accaacatta ttctcaatta tcgttgtagt accgcttaag ccatccgcat 309541 tcttgcccgt tttgttcacc tgctgggttt catcctcgct atcgggcaat tcaaccactt 309601 cttgggaaaa tatcgacctt tctccggttt gtttatttgt cttgatcact ctcttgatct 309661 tgaactttct taattttttt gcacgttttt cagcttctgg ttcgataaga ggggcattct 309721 ttgaaacagc taatccggca ctttcaggta ccagcgtgct agagccattt tcgcgttgct 309781 ttattacgtc ttcctcggta ataaagttgt tttccactcc ctcgtcgatg ttcaccttgt 309841 agtctttgct tggcagccat tggccatcaa caataaactt gaaataaaac ttgctgctag 309901 ggctatcaaa cgttactggc agcgttattt cgaaggcgcc actggggtcc ttcaccatcg 309961 gcaaagtacc tttccagtcg tcgaacgtgc ctgtcagaat aattgcttcg ggtcctttgg 310021 gccatttgaa cgtaaattga ggtaagctcg attgcattct agaaacactt tccctttaat 310081 attatcttat aatgcttaga aagttaaata ccatcaagag aaagaaaatt aggtaataca 310141 gaggacagaa ggacagaagt cgtttctata ttacataaaa atcggccacc ttttattttt 310201 ttaaaccaca agagaggggg agaatgatgg atgtaaaacc ttaaccatgt caatgcaagg 310261 gctcccgccc caaaagttcc tatcgggccc cttcgcttcg ctgccccaga tatttgcgga 310321 aaaggccagc ctcgcagtat ttcaccaatg cccttacttt gatagtatgt attttgacta 310381 ctttttttca tttttatcgc ttctttttac tttgtgcggt gtaaacccta cacaaaatag 310441 ggctttcatt tagtatttac atttgcacaa aagtagagaa gatacgtaat agtcattgaa 310501 agcatcgaca tttttggtgc ttgctgacaa attcacggtg acaaagtgag ctagaatatt 310561 gcttatcgat aatcagtgtg ttatagcagc gttttaatct gtttttcctt tctttagttt 310621 ctagcgttat aacttatgac ttctaagccg tctactagaa atgattattt accaagggaa 310681 actcacaatg gcgaatatac tggtgattct cccgaatggc agttgcagat taatatcaca 310741 aacaaaatag gtggtataaa tggagatatt tggttgtcaa gggacggaag gagtgttaaa 310801 tggtgtattg aagaccagtg cttacgtcag tttacttata atcaaaagat catcaaagct 310861 gggtacattg attttgaaaa gacaccagat tgttttgtgg tagttctctc tgatattgcg 310921 catgtatata tgttgaaaaa tgggggttct acgactgtat gtttcccatt ccagataggt 310981 aatgcattct ggtatgcaaa tggagtaatt ttagagagag agacttcagc gtccttcatg 311041 gatggtggct acgatttaaa acccattgag ttcgatttaa aacataaata catcactttg 311101 acggatccga tggcgccttt cggcttgatt tcgatcacaa atacctttaa aggcggtata 311161 aatagcgctt caggtaacaa aacggatatc ctgcaagact ttcagctcgt gctcttcccg 311221 agtgacaagg acaagtgtat agctgttttt ttagatcgaa attccaaagt gttgcgattt 311281 tattacagta gaattctatc atcagatcag tcacggaagg gagagctaac aatttcctcg 311341 accaaaaaaa caggtttgga cgcagcaggc aatagccaaa agagtggcgg gattagcaaa 311401 gatttgcgta agttttcaca tttgacgcgc cggtcgacgt ctataaactc taactctcat 311461 gatttcaatg cagccgaaag agtacttagt ggcaatgttg gcaacgcttc aggcagaaca 311521 gatattttcg ctttaccttc ttcttgttca agaaggagct tatctgcgac cctagataga 311581 atggggaaca atattgcccc gaccaataga gctgcacctt ctggattttt tgactcgtca 311641 tcagcaaata ctgctactca ctctaatata acgcctgtat cacaaccaat gcaacagcaa 311701 cagcaagaat atttgaacca aacagcgacc tcttctaagg atattgtttt gacggaaata 311761 tcgtctttga aattaccgga tgatatcatt tttacttcac gacgcttgag ctctatttta 311821 agtaaattaa agttcctatc gttgagattt gaacgtcgag aaggactttt aatatttcat 311881 gagcccacac atttctgcaa aatctggttg attgatcttt tacccgatgt tctggattct 311941 attccattca aaatatacgg gaactctccg caaaacatga tcagactaga gaacttaaag 312001 cttaaggaac cctcaagaat acaagctatg tatattcatg aactccttga aagttgcctg 312061 attttggtgt cggagggaca gaataaggaa gaatacaaag catgtctata tgaccccttc 312121 gttaaaatta catccccttc caaaaatatc tccgaagagc tcactaaaca aaattctctt 312181 ccttccttac agaaactatt cccttatccc gagactagtt tcaccaaact gtgcttcgaa 312241 gccgtcaagt atattacttc tcctgcattc aatatttcat ttatatttct atggcaatct 312301 gcatattcga tacttctttc aagggctaac gacgacgtag ttgggggttt gaaaatggag 312361 cacgatgctt tttcactggt tctttcattg ctgattttac cgatacctag ctcctctgct 312421 caagaatacc aggagtacaa agaaatatat gaacgcgacc tgtttcagca tttaaagcag 312481 gactcagaaa taacaagctc tgtgctacca agaattgtta ttggattgca tttaataagg 312541 gaggaatatt ccctgaatgt attgtgtcga aatgagcatg cgttgttagg acagtttcta 312601 agattcgcta ctgccgcgat gggctggcct gatctgtggc aatcttacta tgtaccgaaa 312661 atggattcag aatcgaaaac tttcctacat ccaagggaac aaaattccac tttttttcat 312721 cccttagatg aaccgccatc gattaccaag tcgttataca gcataactga aaacagttca 312781 ataccattat gtccgttcat tagtttctcg agacttgttg caaccgatac acaggtcgaa 312841 ttacgcatta ctccaagaag tttcaaaatc ttgggcttgt atgaactcgt acactctcca 312901 aattttttac cggattatgt tttaggcatc ctttccagct ttaaagtgga taaagacgag 312961 ttacaaacat atcccttagg cattttggtg cctttacaaa acattttaaa aattctggaa 313021 gataagctat ctgaagtaag agacaacttg gagttattag atagggccga tttacaaagg 313081 tgtagtgcca ttatcaatag tataagaagt gattctaaag aagttctcaa aagaggccaa 313141 agagatagtt atatgttatg caaagtgcca ctcgccaaga acagaagctc tttgtctaag 313201 aagcccagtg acatatattc aatattatcc gagattgtga aaagtgcaag tcaagttcca 313261 ctggatggat cagctatgag gatgtcgaat attcaggatg atgaagatat tgatgaaggt 313321 cgatctctca aattaaatgc aggactgatt ttttcagaag ataaaagatt tactcatgtt 313381 gtatcactat tagcttatta caggcccaca aaaactcaat tttttaccac caagacagaa 313441 tatgcccaga tactagctca aaagaaatat ttcgctaaaa tcatggcttt gaggacatgt 313501 acaaatggtg ttggctgggg tgcagtggca tatgcaacag aaaaaccaat atctacccaa 313561 aaatgggtca ttcaacccct caacttaatt tccgtgtttc ctgatgacac aaagataact 313621 gtgaaagctc cagaagatat agcacacgat attgtggagt gggggcaatt tcatgccggt 313681 gttagctccg gcctccgtat ctcaaagaag gcaactggaa ttacaggtag ttggattgca 313741 tttaataagc caaaagaact agatgcttat cacggtggtt tccttctcgg actgggactt 313801 aatgggcatt tgaagaattt agaggaatgg catatataca attatctaag ccccagaaat 313861 actcacataa gtattgggtt acttttggga atgagttcaa gtatgaaagg tagtatggac 313921 tctaaactaa tcaaagttat tagtgtacac ctagtggcct ttcttccaag cggatctagc 313981 gatttgaata tagatctaaa actacaaact gctggtatta tagggatggg tatgttatat 314041 ttaaactcaa ggcataaacg aatgagcgat tcaatttttg cccagctggt gtcactgctc 314101 aatgtaaatg atgaaatggt tgctgacgaa gaatatcgat tagcagcggg tatatcgctg 314161 ggcctcataa acctaggggc tggtcagacg aaactgagaa agtgggattc atcattgttg 314221 ggcttggggg acgatcttcc ggaagatgtt tatgactcta gtgatgttga acaaaatgta 314281 atgtatgaag acctgactac gaagttatta gagatcgtca caagcacata tgatgtagaa 314341 aacgattgga taccagagaa ttcgcaaatt ggcgcagtaa ttgcaatcat gtttttattt 314401 ttgaagtcaa acaattttgg aatttccaac atgcttaaag ttgacttaaa ggaaatatta 314461 aaagcaaata ttaacacccg ccctgaatta ttaatgtacc gagaatgggc atccaatatg 314521 attttatggg aatttatagg cgacgaccta tcgttcatca tgaaagatgt tgatattgga 314581 gtaaaattta gtgaacttaa taccgatttg cttcctatat attacactat ggcgggtagg 314641 atcttagcca tgggtattag atttgcctct actggaaatt tgaaaattcg gaatatactg 314701 ctttctctcg ttgataagtt tctgcctctt tatcagtacc caggaaagca gaatctagac 314761 tttaggttga caatttctgt tattaacgtt ttaactaatg tcatcgttgt ttctttgagc 314821 atggttatgt gtgccagtgg cgatttagaa gttttgagga gggtcaaata tcttcatgaa 314881 gttgcatctg gtccatattc agacttattt caagaaattc ctagttctaa aagtgatgtt 314941 tcaggtgtaa cacaggtgac ttcaaacact aacacgcctg gaaatagtga tcgtgaaagg 315001 gttgatgaga ccgctgcttc tctcgatgac gaaaggtcct caaatggcag tgatattagt 315061 gatccaacag catatctaga agacaaaaag gatatagatg accattacgg taagtttatt 315121 tcgacaaatc ttgcactggg ttttcttttc cttgggtctg gacaatacgc tctcaatact 315181 tctactttag aatctatcgc tttcttaagc atgtccgttt tacccacata tacaactcca 315241 catcccttac aagaattgaa gcatttctgg agcatggctg tagagcctcg ttgccttgtt 315301 ataaaggaca tttccactgg tgacgcagta aacaacgttc ctattgaatt ggtggtcgag 315361 gaagacgtcg aaaaagaaga agtaataaga gagatatcaa caccttgcct gcttcctgat 315421 ttctccaaaa ttaaatctat tagggtaaaa atgcatggtt actttccact ggaagtaaat 315481 ttcactaagg actactcagc ttctgatttt tttagtggcg gtacaattat ttatatacaa 315541 agaaaatccg aaagtgtttt cgagaacaaa gcctctttta ggaacgtaga agatattcat 315601 gtggcactca aaagaaaggc agcagaatct aaaaattatt caagattaaa cctaaaaaat 315661 gaacaaggaa ataccacctc ttcgcaactg gttgaaagtt tgggtattca agatttgaca 315721 atggtggaac tcgatactct tttgagtgca ggaaataata cagcattaac ggattcagaa 315781 tcttataatt taggtttgct gtgttcagat aaaaacagtg gagatatttt ggattgccaa 315841 ctcgaattgt ggtacaaaag ctttggacca catgatgaat aatgcaaaac tcaagaatat 315901 ttatttgggt atctaagact agctttaaaa ggttccaaaa ctggggtaag gtgtaatctt 315961 tgtgtataac ttggtttatg aaaggggtac atgacatggc taaaattctt cagacgaaca 316021 tctttaatct aaagtttaca tctaacaagt ccaatctgaa aaatgtacag cgtataattt 316081 tacatacctc caaaagaaga attaaatcaa agtgtgcaga taatactata tacagcaaaa 316141 taaatgctaa ctttacatat gattgctttc attttaaatc attctttcca attatgccta 316201 atttctgtcc catcttaacc ttatcaccaa ccctaacatc gaacttaaat tcagtgggag 316261 cttcaaaaca aagtacaaca gtgctaccca attcaaagcc acccatttct tcacccttaa 316321 ccaaaggcat ccctcccaat attttacttg cattctcata tactgcctgg tagcaggtat 316381 gtggttccaa gtgtttgtcg ctctttgaat ttgtcacaaa ttcttgatca aaattcaact 316441 tgattgaacc aacatttgtt gcaccaacag gagtcatgct aaaaaatccg tacttccaac 316501 tacccaacaa agcaactctt tcatttagaa cgaaaagatt agggaagtta cgctggaaat 316561 aaggtgccac ggagaataaa tcacctggga aatggcggcg aaccttacaa acccagtcaa 316621 ctggagagtg gaaatgatgg taatcaccgg gagccaaata aatgacggca aagaaaagtt 316681 ccgtatcatg aggctcagag cacgaaaacc cattagagaa gtagtttaaa gaaagttgac 316741 ttaaaagatg tatatttttg gacacacttg gtttgaactc tcgaacagat tgatcgccct 316801 cgtttttaaa gttaagaaga ggctgttcag tgtcttcgga acccgctaat tgtattctat 316861 ttaccctggc gaattctcta tgcttttcct catcagaagt caaatctaga ctagatgcac 316921 tcttagacat caaggggtgg gagtgagtgc caaggaattc tttgatggaa tatgtcattc 316981 ccttgacttg ttcgatttcg ccagtttcag agttgattat accaacttgt aaaatctttc 317041 catcacttgg agaagctata acgtcttcgc cttgtgctac tggacgtgtg cctggtttta 317101 tgttacgata gaaaaattcg gataaatttg cataatgtgt caaatcagga tcttccatct 317161 cgtccaagtt aactccaaaa aggaaagaat ataacctgta accccatggt ctaacccaaa 317221 tgggtaacgt aagagaattt acttggcccc ataatcgaga catcgcattc agcggtaaag 317281 tagaatagca gaaaaagagc caattattgt taaatatttt gatttttctt gtccttctcc 317341 cttttttgcc ctctgtagca tcctcctctg tactatcatt ccttgacact agtaaaatgg 317401 ttcctagaac aatggtgaaa ctagttaaaa caacccattt catggagacc tgttttcttc 317461 cgctatttgc ggcagcagct ttggcacgat ccacaatctc tccagaactg cgtcgttgct 317521 gaacgaaaag acgcgtggaa aactttctat tccatagcac cgcagttcta tttcttaatt 317581 gcattcttgt agaaaacttt acagcaggca tcctccccat gaggagcgtc ctcccttgcg 317641 ccaaggcgtt cttaactggc ataattgaca tgctggcttt gcttttcctt cttcttcaaa 317701 aaataacgac caagaaggat ttgagcgatc tgctaacaac tggctgaaga gtccttaaag 317761 cgctacgtac ctctaggcgt ctcttttgtg agtaagctgt tttatattat aggtgaagaa 317821 caaattttcc acatgcttgt gcctgcttta gatgtccctt gacctcgaga tttgaaaaaa 317881 caccaaaaag gtgctggtta ccctgcatgt gatatgtgat tacatagcgt agcgtataca 317941 gaagcacaat tggtcgtata tgtgccaagc ttgtaggaaa ttagtaacgc ataacgtgtt 318001 atctgcgaca agcgtgaatg cgacagacat tatgtttctc taaattcata tggtcccggc 318061 cgattttcac attcgaagtt catgtcgaca atattgtcat tattctgcaa tagctcacag 318121 tgaacacggt caccaggctt taactcgcct acacctgcag gtgtaccagt caaaatgata 318181 tcacccggtt ccagagatat catggtagat atgtgttgca gtattttatg gagtgggtgc 318241 aacatgaggt tagtaccacc atcttgtctc aactgtccgt taacagagca cttgactctg 318301 aaaatatcct gtaagtttga tttgtaggat gagaacttct cgcgggagac tatagcagag 318361 attggcatga aggtgtcaaa acccttgctt atagtccaag gtagcccctt ctttttggct 318421 tcatcttgga catttcttgc tgtaagatcc aatgctagag ctacaccact aatagagtca 318481 tagacttctt cgggtttcat cttagtgaca ttggacaaat gtttgctcac aatcaatgcc 318541 aactcaattt cgtgatgaac cttcacaccg cgtgggataa aaatgggccc ggggttagtt 318601 ccgtcttcat ttaaaccatt gaaagtcgag tttgcaggtc tagtggtctt gaccaatgat 318661 gaagacaatg gtgtcacaat actcgaggtt ggttttagga aaaaaaacgg ttgttttgga 318721 gttgaattgt tcagctcttt gatatgcgct gcgtaattac gcccaatgca tataattttt 318781 ctagctgcct tcaaataatt gtagctcata acgttttggc aatttcctga gtctttactc 318841 gatagctttc agaatatttc tatataggaa gttctggctg aaacgttttt ccttatcagt 318901 tagagaacgg tgaccatctc ttgaaagcga acaaaaaaac gtgaggctaa ggaagctatt 318961 taggaaaata gacgaaaaag gaatggcaaa agaaggaatg gccctttcaa aataggtata 319021 agcagcacag cttgatacat gctagggttg cagcagtata actgtactct ctttatgagc 319081 gtagtgaaaa gacggtgaaa ttataacggt atgctctatg aagaataaat gctgtaggaa 319141 aatttacgat aataaagcct ttattgttgt tgatcaacaa aaggaggctt aagcaattga 319201 taaacttctg aaaagaagaa ccctattaaa gtttatatca aatatagaaa aaaaaatctt 319261 gaagttacat aaatacagaa aaaagcggga gaataaaagg gatttcctct taaaaggaac 319321 tttatagtgg aatatttgca atgagaaaag cggacaggtt gaagagtacg aaagcatcag 319381 atagaagact atttaagaac cccgtcgcta tctcgtcaat tattgtgagg tagagtggat 319441 agtacatcat gcttattagt atcatgggta tcggaatttg catttattac caatggatta 319501 gtaacagagt agcatgaatt gattatattc tgtgcactat ttcccacatt attagtagtt 319561 gtgttacttt tgctgatatt tgctccagag ttcagtgagt attttttatc tagaattatt 319621 ggtcttgaat taacggaagg atagcccgca ttttcgcttt tgacaacgtt agtgtcctta 319681 ttgaagctgt cttcttggcc atccatgtcg tcccttgggt ttttgcctcc ccttcggtaa 319741 aaattcgttt cacatatcaa ttgcttcatg tttgataata ctgacattgc acttgaataa 319801 tcactccttg aaatgctact ctctaacaat gctattaaag atgtagatgg tggtgatgat 319861 gatgacggag ttgaaacatt cacattgaat tgggaattcg aggagcttga gggtattatg 319921 ccgcatagct tcccaatgac ctgagttaga tcgtcatatt cagattcata gaattgtaga 319981 tcattttcaa ttttcttgat gtactctttc tttctttttc taaatttaga tgcagctact 320041 ctatttcttt ctaaaaactc ctttcttttt ctttcttgct cttcattctc atcaagtgtt 320101 acgttgtttg aaattttatt attttcaaca tcatcttttt gtgctggtgc agtcgtaact 320161 gctgagtttt ttcttgatat ggaatttttt cttgaagcct tagaagtaga acttgtgcta 320221 gacatccttc tctttctttt tcgtgttttg ttattgaact ggtcattgtt ctcaatttga 320281 gtcgttaaat tttcattctc cttgtgatta tgagcggagt gctcgatggc attgaactct 320341 gccggattat ccattttgac agccgctttc gttgaagtat ttggggaaaa attggaatta 320401 ctgatgctgt tgttgacggt accatctgtg gtatttgttg taggtgttga tttgaatact 320461 ggattagcca aaactccagt agatggtaag tttagcagag aactcaatcc cggcgtaagt 320521 ggtgtaccat ttacagttgg gtgcattata ttaacatgag ggtggttttc aatacttcca 320581 ttcactgtga cacttttgtt gacatttttg ctacctgtta tagtattttt attaattgac 320641 ggcaatacgg gataattgta agattgcgta agaataccgg gtgtcaaccc ggtcctgata 320701 ttggactcat taggtgtcaa cccagatttg gacaagttta ataaaaagcc aggcatttgt 320761 gaatcattcg tggggaagcc gttaccagaa ttacttgtgg tcacgttcga gtttcgtggc 320821 tggcgtataa gtgaagtccc tgaaggagaa gagctgtttg gatacagaga tccggaggta 320881 gaagaaacgc ctattgcact agggtttgaa ttagagactg aaacagaatg tgaattctga 320941 ctgggattcg tagttgaatt tgcctgatat aaaatagagg gagaaaggag tagaggtggt 321001 aatcttttcg acccaccagg tgtgagaata ggcggagata ttatagtagg tctttgttgg 321061 cctggtaaaa aactaggtga gtcttttttt acgtcattat gattactatt atctgtaacg 321121 gttgaattcc cattttcttc tggaatactg ttcaaactat gagtggaacg ttgggaatgt 321181 tgtgttatcg ttgaggtaga attgtttcgt gaaagctctt ttggtagaga cggatgggag 321241 atcgtgcctg gaagtgacaa agccttcttg gaagaggcga agctttgttc aaaaggattg 321301 ggttctaaat cgaaagttga aacagtactt ggttgtctcg agcgttcctc gcttgacata 321361 atgattaagc agggtctaga gactgggcag gtgtatttgg aatgcagaaa ttgaaatgaa 321421 aagaatgaaa taaaaataaa aatccacgaa ttgattaagg aacttatcaa ataatagaga 321481 tcggtaaaaa gataggaatc taataagtgg aaaactcact tgaataataa aagagttttt 321541 ctcgataaga aaacacaatt cacttttacg ttgaacccct ttggtagtaa cttttctgag 321601 cttaaaacca ctcctgagcg ttggcaatgt agcaccaaat tattgtgttt ctggagaaca 321661 aattagtctc acgtatcagt aaccaaactt ggtcctttta actggaaaaa tgtgcagttt 321721 gtttcgaaaa ccatcaccgt atgactgaat tcattctatt cagcccagtt aattttcgtg 321781 atttttccct tcgattctac ttttttccct ctgcgacaaa gttagcaggg ttatcgctag 321841 cgcggttaag tacgacttgg tttatgaaag ttcttagaga aaagaagaca caacgccatt 321901 gaaattgaat tctgggtact gttattgttc cgtttcatgt tattacaata taattgacta 321961 tctgaacatt ttgtcttcat tttttttttt ttttattatc gttttgttta cgtttaggcg 322021 aaatactcac ctctttacta ttaaaataat agaatttatc agaaaaaaag tcagcaacat 322081 caaaaataac agatggatgg ctctaggata aaggattctt attctcttac gattgtctat 322141 gttcttttgg tatttatttt aactttatat atctgtctta atttataaat atttataaca 322201 acccttggcg taatgtaatc atttagttcc aatccaaaat tggccatttt cgccacgatc 322261 aatttgcttt ctcagatgtc tacttaataa cactccgacc tcatatttct ccttcgtttt 322321 cttgtcaaga tattcttgaa gcttcactac ggctctatgt agtctctttc cgtcttccat 322381 agataaagaa ccctgtgcat tcatcttgtt tagatagtca atttcctttt gtaacttaat 322441 gcatttcatg gataaataat catgtctttt ttccagcttg gcaatactgc ccagctcaga 322501 cgctgatgtg ataggagagg agactggcga atcatactta tttagtgaag atttacgact 322561 tccgtttctt gaattggaat tgctgctcac cgagataact ctgaacggat ttgtagggcg 322621 tcgtgtctcg aaattcgcca tttttttctg tccatcacca tctgaattaa agtgatttat 322681 attggtacca tcttctttag aattcttttt agggataaaa attttagttt gagaatctaa 322741 gggagtgctt cctccagagc gattgggaca attctctgaa ttatcgtcat ggggtgtttg 322801 atcagctaaa cggctgctct catggttgta ttcattgtca cctcctacaa ctatggtttg 322861 cggttgtata tctagatcct tattagcgga agaaaatttg tctaatacaa gttcagcgtc 322921 taacttgttc tcaccgccca aggtgttatt ctggggcatg ggtgatttga aagattcaat 322981 ctcactgttt tcctctgttc ccttatctac tcgcccctct tcaacatccg atttttcatc 323041 ctcccattca tcatcattat tttcgataat ttcaacatca gcttcacccc tgttttgatc 323101 tatattgact gtaccatctt ctttgttctc agtgcaggag tcctttgcct tttcatttcc 323161 agcggaattt gcgacaaatg aattatagga gtcaccaata gcaatggcgg tgtgagttat 323221 ctgctctttc gctataaaag gttgagtaac cgatagctgg gatgggtcat ccgtactctt 323281 attcgcttca ttctcagtgg gaatatggac ctgtgcggtt ttgtgctctt caacctgagc 323341 tgaatctcct gggttactat ccgctccatc attgccacta aaaagagccg tttctgccac 323401 ctttacagcg tcgaccacac ccgtatcctt gacattatct tcgacagctt cgtcctccgc 323461 aggttcaact aattgtaaat tttcgtcaat catctggttc atctggttga tatctatctc 323521 tatttgagaa agcctcttct ttatcttgtc ctggtccaag cccatcgttt ctgttgttct 323581 atttcacact aacatagcat caccataaca gtaaatcaaa ttacaaaact attaatgatt 323641 tttgtttatt atgaagtttg aattttcagc gcaatattta tttcataacg cgtctaaaat 323701 ggtctgggtt ctgggcatct ctaaagccct tcactactag tgaagaagaa gaacaagtaa 323761 ggcttttgga aaagaaagag catcaaattg aacgatagga gaagtgctac atacatttgc 323821 caaagatccg catggataga gtacgctctt tgattggaaa tcgccgggga cgccgacata 323881 atcgccaaca tcctccgtat cctcacagtg ggtctccatc caccgtcaat ctcttgggag 323941 ctaatggtta tggagacgac caatctacaa tatttgcacg agaaaatgaa tctctggaaa 324001 cctctgccaa cgagggcgat gatagtgcgg atgcagctac tttgaataca gcggtatcag 324061 aaggctcaac aattggagac ctacaaagac agggttatgt taacagagcc ccaagattca 324121 cgtcagaaag agccatgcca ttcgtttcgg tgctactaca acgagggttt tttgcattcc 324181 ccagtgaaga atctctccag ctatttttac acaacaagag gaagctcgat aacattgatc 324241 caaagagggg tctaggactt cccctatttc acgccatttc tttaaacctg gtcaagtcgc 324301 ttttcagtga tcaaaataca ccggtaatga ggatatataa atacgttatg atagactccc 324361 aatgcgataa acctccatta aactcagaag tggtctctcg aataaacgaa aatgtctcca 324421 tatataaata tgaattctgc actattctaa aaaaaatgga aagccataat ttttcgagca 324481 gggtagagca cgattttata tttcatagaa aagatgaacc tgatgttcat atccccatga 324541 ttaattacaa tcaaaggaaa aatgcggata cggcaattca tggattaaat cttcgttggt 324601 acgggacaac tagtttagct tcaccttttg gctcaaatag catcaaccta cttgtactcg 324661 atgatacgat ggcatcctac atgaaccaac aaactattga agagtttgat tcttacagcc 324721 gttcccgtcc cacaagaccg ctgggttatc tcccagtatg ggccagatac acagatgata 324781 aagttagtgt cataccgaaa aaaagaactt tgagagtagc taccttgtac ttacaagaaa 324841 ctgattcgtt tgatgatggc tctagtttaa catctaccaa ttatactgaa atgggctcta 324901 atatcattga aaatgtgccg tgggatagtc agatacttac ttgcatgtgc atgctattac 324961 atgaatatga atcaagaaag gagaaacgcc acaccgcatg gggcagctcg accacatata 325021 tgctaaatgg accggcagga ttactgatgt aaacccattt gcatttactt gtgttttttc 325081 ctgttactat ttagtcataa taccgctaag aagcatataa atattcaaag agaaatattg 325141 tcgtacacca ttaatttttc aataactctt aaatacgttt agaatgtcac aagttttcct 325201 cacaagtttt cctctattat gtaatgttcc ctatactact ttattcctac agtaataatg 325261 ttgactatct attccttttc ctactatctt gttcatctct tggtggattc ggcatacgat 325321 tgtaaccaaa cgtacgatta taccacttta tcatgttacg tggtggttca ccaaacacca 325381 tgtagtactc gcaaaataaa cacatgggac ttgattcgtt aactaggaca gagaaatctg 325441 gaacacggtt ttccgttctg gaaatatatt caaaatcatg ataatagtag tttcgtagtt 325501 tggataagtt ttcataatga tgatgcgggc aacaactttt atggtctcta gattcgtcat 325561 aaaagtcatg tcgccttaca tgcccattct ttttcgagtt ctttgacctg ctgtgctttc 325621 tagaagatat ggaatgttga ccgtctccat gcaaacgagc tgcgtcaacg gtatcatgat 325681 cgatatctgt gacttcttct gcaacatcta aatcctctac atttgttaca gttcgcaacc 325741 ccccctgttc ttcacttcca aaccctcccg gtaacaccga ttctatcatt tgagaaatct 325801 tttcccctat accatccggt gtatccagtt cttggctctc ataatcgaaa attatttcgg 325861 cttcttcgcc atccaagtta agttctgagt ctttaagatc atcatctaaa atattttgca 325921 agtcctcctc tattatgaag tctgcactat ttctagaagc tatttggcct attttacttt 325981 caaaggtttc cttttcctct gcggaatcaa tgtggtatgc actttggcca tctattttcg 326041 caagttcatc ttccaaactc aacgagtcca tcttaggaag agcatctttg agctcttcta 326101 accgtgcatt tgataaagct tttcctccat ttcttataac gaattgcatt gcatgaggag 326161 cgttttgaaa agcttgtctg tcttgaagct gattggaaag aattttagtc agcgctttca 326221 caccttcttg catcataacg tttattggca taggtccatc ctctgaaagt acctccacag 326281 atgcattagt cgttccacta gattggtttg taggtgtcat tttcttgatg atatggcatg 326341 aaaatagaag agaagagaat atgattaaag ctataaattc gtcgtaagaa gcacgatatc 326401 agtaaatatg gataacaaat taccaaatat ttagcaaaga aattcctatt cagggtatat 326461 gcaaaaagtg caatctgtag ttcttgctgt agctctcgct tattttgcca ttctcatcgt 326521 ccagatcatc tcaactttct tgtcccatcg ctaaaacatt cactcgcgcg agagtatgta 326581 gtatatcata gaatacgtaa gactggaaat gcttgaaaac tgtgctattt catctcatat 326641 tcaagtgaat atacatacat acatacatat atttatatat attttcaact agtgaaaact 326701 atctatatta gtctatgatt catataaacc ctaaaaaacc ttaattcttt ttcaaagtac 326761 gttgtttttc ggcattttcg acaacttttt cttcaatgaa tagacctttc cttcttctga 326821 tggcattcat atgcttacgg gcaatattct ctctatctgc tgtatcacct agttcctcca 326881 attcttcttc tgtggttggg acccaaaatg gatctaaatc gatacactcg aatccggaaa 326941 ataccaattg aggttgtgct gcaccagatg ttcgtttacg aatatcttca cttaaaccga 327001 atgcttccac aacgggcaca tgtgcctcaa tttgaaaaaa cggtgtacct tctttcattt 327061 cttcagaaat gattttacca tgcctctgta gaataacggc atacactttt ccaagtacat 327121 cgacagaggt ttgaatatca catgagtaaa ttgcccacat aattcttggg gaccagtcta 327181 aaaaggcctc atgtatagcg tcccttgtag aagttatcaa cctccctgat aagtccacaa 327241 tatgttgttg gtagcgcgga tcttcaatag attcaatttc gtcttgtgac atcttatgta 327301 cgctttcaac aagaacacac attccctgta cgggctcatt tgccagaggt ccttcgctaa 327361 cagccagttg gaagccattt ttgatggaat ctgaatactc aaaggctgct ggagtacctt 327421 caaataggct tccaagaaga ttatcctgcg acagcaaaat gttgcaccca actctacttg 327481 gcccaaaacc tgctaacttt actttaaacc cacttaatag ttctctgctc ttctcctcct 327541 gatttatgac ctcttcaaaa gcaacgagta aagacttttt gtctagaaaa gaacttccag 327601 ttgattctat gacgggatcc atgcttgaag tggacgtctt caaaatgttt ttaatgctat 327661 tttgatgttg agataaaaag tctgtaactt taccgcttaa tgggaacgtt ctgaatgtaa 327721 tcttgtactg gctcaatagt agttcatgaa caccccttcc cagctgtgaa ttctgcggtg 327781 gattcatatc tgaggctgat aaaaatgttt ccctatatgg aatagccggt tcagaatgtg 327841 taatttctat tcctgcaaat ctctctgtta aatcttttag gcatctttct aaatgtaatt 327901 caccggccgt acacagaatg tgttcaccag tattttcaac gtatgtgtgc acgcaaggat 327961 ctgcttgatc caacaacttt aatcctcgta ccaacttgct catttccaca ggattggctg 328021 gctccacagc aacacgaacg attggcgtaa aatggaaatt gacgcccgct agattgacgc 328081 cttgtacgcc cttctctatc aacgtaccac tctttaaaac tttaccggcc agaccacgaa 328141 taccgactat atttcctgat ggacaaacgt ccaaaggaac caattcctta cccataaaca 328201 aatataaatg cgtaataatc gcagtttcaa tatgctcctc tggacatttt ggatcatatt 328261 ttggacccaa taccgaaatc tcctgaccaa ctcttagtgt gccactgtat attcttgcaa 328321 atgctaccaa gcattcttcc ttttcgtcaa aaatatcatc tacttcatcg ttcacatcct 328381 ctgaaatttg cttaatactc tccaaaagtg gatcttcttc ctcatattca aacattgaac 328441 ttagagggtc atttggatct atgtcagttg gtacaaaatc taggccgaag ttatcttgac 328501 tatctgaatc atcctccccc tcatattcaa attctaaatc caaggcggaa gaaggctctg 328561 aaacaacaca gaaaacatca ttatttcttg aaggttttgg ctttgtctgt tctcctactt 328621 cgggggtcat aacggtatct tttgctcttt tatataaatc tgatgtattt ttagaattgt 328681 cattcaaatc catcattgcc atattttcta ccataccagc atgttttgca gcattaagtg 328741 cttcctcacg tgcctttcta cttctctcca tcagctcatc cgaagatgct atcctcttag 328801 attcaacagg taattcttct ctaggaattg aaagcatctt agatacgtat gcactaactg 328861 gtccttcttt atcacatgtc ttcatggctt tcagaagtct tggatccatg gctgctgtgt 328921 cggattcgga gaccaaaata gtgttcaaac gatcggtttg tgattccaaa ggtgaaggta 328981 atttttcaat aactgttaac aatactgctg tgctgacggg tagccattga cccatgatag 329041 ttcttaacaa ttgtttatcg tccttcgacc ttagatcacg tgcaagtagc ttaatattta 329101 aagtttttgc tattttttcg accatttcag aatctctcga tgtgattatg ttttgataaa 329161 ttttccatat attttcgagg attagcgatg tgaaaagggg tttcagggat cttcccttaa 329221 ggcctttatt gttaataatt ttttttgtct tgggatccat atagaaatca ccccataaaa 329281 ctttctgtag gttttccctt ttagcgccta atttttgttc gtaaaatttg gccaattgac 329341 cgatgttgaa accccaacca tcaattgcgg aagcaaaaat aacgttgtta tcagtagggt 329401 taaagtaaat acccgaatca tccttttcaa tatattccgc gttttcgttc ttttctaatt 329461 gctccctcca aaataaatca tccaattgtc tctcgtttgc gaaaaaggac ccgataactg 329521 agttgacttg ttcaatgact ttggacaagt gaatataagc ttcttgggga gttagttgta 329581 gttctgtgat caatctatca atcttattca atactaaaat gggcttcagc ttctccgtcc 329641 aacattgtct caacactgtg acggtttgcg agcatacccc ctctacgaca tcaaccagta 329701 cgacagcacc atcacatagt cttgaagctg cactgacctc acttgaaaaa tcaatgtgac 329761 ctggggaatc aattaagttt actagatgct cgcttacaag aggctcatcg gaaccttctt 329821 gtttacgcaa taccctaaaa tataaagaga tagccgatga ttccattgtg ataccacgta 329881 gttgttcgtc aggcctggca tctaagaatc gaattttgcc ggcaagcctt tgtgatataa 329941 taccattcga agccaaaaga gaatctgaaa gtgaagtttt accgtgatca acatgagcaa 330001 caatacatat atttcttata caggaagggt cattttgcag acgtttgtaa gtctccgatt 330061 ccactctagg catatttgct tatcgtgctt agaaaaataa ctgagtttgg ttattttata 330121 aactattttg ataatcttga tgatgtacaa agattgtatt tcgggtgcac ctatctatca 330181 atattcttgg ctcttaagtt cccatttttc aaaatttctt ttctcgtagg aaaaagaaaa 330241 aggaagcgat gagctgaaaa ttccacttta caatatatcg aatatccagt ataccaaaac 330301 tacatacaaa cgaacacgtc attaaaagat gtctgataag cccgactccc aagtattttg 330361 tccaaattgc aatgaaagac ttcaaaagtg tttagtacag caaaattatg ccattataat 330421 atgtcccagc ttagtctgcg gctacccatt caatcaaaga gaagtactcg aaaatctaac 330481 gtatgtagac gataatgacg tcttaaaagt tgcaaaaaaa agattatctt cacgaagcaa 330541 accataaaat agttgcacta ttgctgttca ttatctttca ttatccctag taacgccatt 330601 gcagagtcaa atatgagcga taacaatata aagagcaata acatgatagt tgaaattaac 330661 ataaaagaag cgacataatt aaaggtctca aagagtgaag atcaagtatc cggtttttac 330721 gaataatcta ctttctatgt gaaacccaaa aaagttcgta caaggaaaac taaaaagtgt 330781 gtaataactt gtctagcttt ggcattaaaa cttgtcaatt attcatcacc aatatagact 330841 aatgcgtttt ggaacgccaa accgcagtga caaatagcaa atatgtagct gtcatatcgg 330901 catataataa cagttttcta ccaaatgctg tcctacattc agagatctta catccttaca 330961 tctaaagtaa aacctagaca tttacttcga gttatacttt ttttttattt atctattttt 331021 tctcttgcgg acatttaaca cctgaattcc gcctaacgcc aggactgatc ctgccaggga 331081 agggagcttt gtctagtgcc aataggccgg accagtagga aggttacagc agctggcccg 331141 cagagtgatt gggtcacagg aaatagcgca accttctctt ttgcccggga aaggcggttc 331201 aatctacctt cgaagggcta gtacatgagc gcgaaggagg cagataatag caccattaag 331261 tggtccaaat gcatcttgaa atctaatcct taatagagga aaacaacaat tatcagtaaa 331321 aatgggtatg ttataaccat aattcctaat ggtgaataaa atcaggacca ataaagaaaa 331381 gctaatttga tttttattgt caatgaaatt tcataatcgt catgaatgca taaacagaca 331441 cacctagcaa ctgtataatc tgcgcctaaa aagggcgtat acacaaaact aaacgatgcg 331501 caataaaagt tcagcagtca gcaatgaaac cgagatatgc agcaacagag tatcatatgc 331561 atggaggatc ctttctgttt ttctgataat atgctctgaa aaagctccaa acagcacagt 331621 agcctatttg tgaagctcaa aaaaggcttc tatttccctc gctatcttca gattgtgcag 331681 tgatattctt tgaggaagga aacgtagagg ggataagttg gataactgtt atttcttttc 331741 aatatgctag attttgctta ccaccttact gattttttct aataataaac ttttttacta 331801 acattagtac gatgtctcat ctatttcttc tatttagtta acgttccaaa gaccagaaag 331861 acctactgta agggtaagac ctgtcgtaag cacactcaac acaaggttac tcaatacaaa 331921 gctggtaagg cttccttgtt tgcccaaggt aagagacgtt atgaccgtaa acaatctggt 331981 ttcggtggtc aaaccaagcc tgttttccac aagaaagcta agactaccaa gaaggttgtt 332041 ttgagattgg aatgtgtcaa atgtaagacc agagcccaat tgaccttgaa gagatgcaag 332101 cacttcgaat tgggtggtga aaagaagcaa aagggtcaag ctttgcaatt ctgaatctct 332161 ttatgggttt cgcttttgta ttttctttgc tttaaaatct gatataatta catattatta 332221 caatataaaa ctttacgata attcctgcaa ctaatgatgc gttagtacgg ttcgggcgct 332281 ctaggacgcg tgtcggtcgg gtaaccatca ttcttattcg acgaaaatga ttagtttcca 332341 gagaagcagt tgcactccag tttgatctgc agtccagcga ctatttttaa cattcaaaga 332401 tcatttttcg tttgaatagt tgagcaaggt catataaatt tctatatcac acgaataagg 332461 gttcagatat tgctttatta tcggcgaaca ctgatattac cacatagata tcgctctttt 332521 tttgaaacgt aagcgtaaat ttcagtatag gtacacgtct gcgctgatcc ttctgtaatc 332581 ctctgcagtt ttcgcaatgt ataatagcag caccaatcat catgagggtg cacctacttc 332641 aggacatggc tattatatgt cccaacaaca agaccaacag catcaacaac aacaacaata 332701 cgccaacgaa atgaatccgt atcagcaaat tcctagaccg cctgctgcag gatttagtag 332761 caactacatg aaagagcaag gctctcatca atcgttacaa gagcatttac aacgtgagac 332821 aggtaacctt ggcagcggtt ttacagacgt tccagccctg aattatccag ccacaccacc 332881 accacataat aattacgcag cttcaaatca gatgatcaat accccaccgc cgtcgatggg 332941 tggtctttat agacataata ataattccca gagcatggtt cagaacggta atgggagtgg 333001 gaatgcacaa ttaccccaat tatcaccggg ccaatattct atagagtcag agtacaatca 333061 aaatttaaat ggcagttctt ctagtagtcc gttccaccaa ccgcaaacgc tacggagcaa 333121 tgggtcatat tcaagcgggt taaggagtgt gaaaagcttc cagaggttac aacaagaaca 333181 ggaaaatgtc caagttcagc aacaactttc ccaagcacag caacaaaatt cccggcaaca 333241 acagcaacaa cttcaatacc agcagcagca acaacaacaa caacaacagc aacatatgca 333301 aatacaacaa caacaacagc agcaacaaca gcagcagcaa tcacaatctc ccgttcagag 333361 cggctttaat aatggtacca tatcaaacta tatgtacttt gaaagacgac cagatttgtt 333421 gactaaagga acgcaagata aagcagcagc tgtaaagttg aagattgaga acttttacca 333481 atcctctgtt aaatacgcca ttgaaagaaa tgaaagaaga gtggagttag aaacagaact 333541 aacttctcat aattggtcag aagaaaggaa atctaggcaa ttgagttctt tgggtaaaaa 333601 agagtcacaa tttttaaggc tgcgtagaac gagattatcg ttagaagatt tccacactgt 333661 gaaagtcatt ggaaaagggg catttggtga agtcagactg gttcagaaga aagacaccgg 333721 aaaaatatat gcaatgaaaa ctttattaaa atccgaaatg tacaaaaagg accaattagc 333781 acacgtcaag gctgaaaggg atgttctggc tggaagtgat tctccatggg tggtttcgct 333841 atattactca ttccaagatg ctcaatactt atatttaatc atggaatttt tgcccggtgg 333901 tgatttgatg accatgctaa tcaggtggca actatttaca gaggatgtta ctagatttta 333961 catggctgag tgtattttgg ccatcgaaac cattcataaa ttaggattca ttcacagaga 334021 tattaaacca gataatattt tgatcgatat tagaggtcat ataaaattat ctgatttcgg 334081 gttgtctacg gggttccata aaactcacga ctcaaactac tataaaaagc ttttgcaaca 334141 agatgaggca actaatggta tttccaagcc aggtacttac aatgcaaata caaccgatac 334201 tgcaaataaa aggcaaacaa tggttgtgga ttctattagt ctaacaatgt caaacaggca 334261 acaaattcag acatggagaa aatcacgtcg tttaatggca tattctaccg taggtacacc 334321 agattatatt gctcctgaga tatttttata ccaaggttat gggcaagagt gtgattggtg 334381 gtcacttgga gcaattatgt acgagtgtct gattggttgg cctccattct gttccgaaac 334441 tccacaggaa acgtacagaa aaatcatgaa ttttgagcaa actctacaat ttcctgatga 334501 tattcatatc tcttatgaag ccgaagatct aatccgtcga ctattaactc atgcagacca 334561 aagacttggt agacatggtg gtgcagatga aataaaaagt catccatttt ttcgcggtgt 334621 tgattggaat acaatcagac aagtagaagc accgtatata ccaaagttga gctccatcac 334681 cgatactagg ttcttcccaa ccgatgagtt ggagaatgtt ccagattccc cagctatggc 334741 acaagctgcc aaacaaaggg aacagatgac aaagcaaggt ggaagtgcgc cagtcaagga 334801 agatttacct tttattggct acacttactc cagatttgac tatttgacaa gaaaaaatgc 334861 gttgtaggga cgcgttaagg acattcctct ttattcaagt atttatctat ggatgtagaa 334921 cgcacattat gaataaataa ctgcactttt ttcgggaaaa aaattaccaa aatagacatc 334981 agctttatca tatgtctcct tgaagtattt gaacgaccac ctttccgaag acaatgtacc 335041 tagtaaccta caggctgccc ttaatccata catccacgca caatagcaca atctcggtga 335101 tggctggttt ttttaccttg aaaaacaaga aaaatggctg atgtagttga aaaaggtaaa 335161 agagatggca gatcagggga cgattttgta gaggaagtat ctatatatat cgaccatatt 335221 gaaaaaaata tgaaataaca tacacacgtg taagaatata taatttttgt tattaacacg 335281 tcgtaaaaga gaaaagatcg tgctttcatc acgcgcttcc tctcggcctt tcgaactata 335341 aattataaga tgatccagtc ttacaatact gaatgaaact cagggaagac gatagcggag 335401 gttcgacaac cgatcactgt aaaacctaca ctttcaagtt cattaatcgt cgcttgaaag 335461 atcgtcataa ccaaatattg ctagaaacaa aagcgttcgg gataggtcaa accatgatga 335521 actagttcca cacgcatatc ttaaagcgtg ctatttttta aaaagggcaa atttaggaat 335581 gtctgacgga atccctaatc atctttggct tttcccttca ctcccttctt ttaccgacga 335641 tggtttgaag gaaagagaaa aatgagcaat aggaaaattc agtagtcgat ttccatttca 335701 attccctatt gggtaatgtg gcggcgaggg ctaaacattc ggtatcattg attcaatgtt 335761 ctcacaatgt tcaaattctc ggatcgggta tccctaattg ggatctcttt ccagaggaag 335821 gggccttgat gtgggattga agacacatga gtttttttct caccgtcgaa acttttgctt 335881 acccgtaaaa catcggccat tcgttggttt attatgtgac ttttttgtga cttttttttt 335941 tgcgaagttt tctcgtcatc cgcggaagat ccggcgggcg aaaaagtctc tcacttttac 336001 ccaatcgggg catgttatgt ggacatgtta tgtgtccaag agacacatga gcccaaaaag 336061 ggtacactgt ctaaatagtt taccctttac gaatcgaaac ttctcgaaga aggggccgaa 336121 aattagcgca gaagttgacg aaagtttata cttttcctaa tggagaggct caggagctga 336181 aaagggatat attcgtactc tattgcatct tcaaactccg aagaatctca gtagggagtg 336241 aagccggctt ctcgatgcta cagttcaaca tcgatacttt gaagaaagaa agcgcctatt 336301 atatctcttt taccctatta gtaataatta ggaaaaaggg agaaaaaagt acctcactaa 336361 aaaaaccatc atctctgaaa tataaaaagc ttgatagagg gtgacatttg ctagaacttc 336421 tgctgtgttc tcttgggtta ttgctcttat tgaatatccc ttctatttct ttcttgcttg 336481 taaaaaatca gctcaaaaaa catctacagg attaatcgtc agttaagtaa tacagtaata 336541 gaaaatgaag ttccaagttg ttttatctgc ccttttggca tgttcatctg ccgtcgtcgc 336601 aagcccaatc gaaaacctat tcaaatacag ggctgttaag gcatctcaca gtaagaatat 336661 caactccact ttgccggcct ggaatgggtc taactctagc aatgttacct acgctaatgg 336721 aacaaacagt actaccaata ctactactgc cgaaagcagt caattacaaa tcattgtaac 336781 aggtggtcaa gtaccaatca ccaacagttc tttgacccac acaaactaca ccagattatt 336841 caacagttct tctgctttga acattaccga attgtacaat gttgcccgtg ttgttaacga 336901 aacgatccaa gataagtcat ccgccggtgc cgttgttgtt gccaacgcca aatctttgga 336961 agctgtctca ttcttcttct ctatcatttt tgacaccgaa aagcctattg ttgtcactga 337021 agattccgct tatgccattc cagtcgctaa caataagaac gctaccaaac gtggtgtctt 337081 gtccgtcact tctgacaaat tagtgtactc cggtgtcttc actccaccta ctgcttgttc 337141 ttacggtgct ggtttgcctg ttgctatcgt tgatgaccaa gacgaagtta aatggttctt 337201 cgatgcttct aagccaactt taatctcttc tgactcgatt atcagaaagg aatacagtaa 337261 cttcactact ccttatggtc tattagaaaa cggtgttcca attgttccaa ttgtctatga 337321 cggtggttac tcttccagtt tgattgactc cttgagttct gccgttcaag gtttggttgt 337381 tgtttcttct ggttctacca actcaacctc atctactatt gaaagcactg aaatcccagt 337441 cgtatatgct caagctaaca ctccattaaa ctttattgac aacaaagatg ttccaaagaa 337501 cgctgtgggt gctggttacc tatccccaat taaggcccaa atcttgttgt ccattgctgc 337561 cgttaatggt gtcacctcca agtccgctct ggaaagcatt ttcccatgaa ctgatagata 337621 ttaaatctag cgaagcatag agattctttt tttaccagtc atcataacca ttattttaca 337681 aaatttccac gcaacagctt ttattttcgt tcgtaatagg aaccatactt cccattaaag 337741 cagtatgatt gttttataca cctttttatt gttatttaag acatacccca aataattaat 337801 taattaattg atgaaagaat catataaatt cttggccata catatttttt tattatcttt 337861 tgctacattg accataggtg aatatcttcc cggggtgaca ctccactgaa gtgggaaaaa 337921 aagaaaagtt ttaaaacatt gctcacctta agtctcgaag gtctagcatt cactacctgt 337981 aagtgtcaag accccacatg tatacatgga tacaataaag aaacaatgtc cgtataattt 338041 gtatacattt tactacagat aagggatctc acccccttct tttgtgtcta agtgaaatct 338101 tctgatatat ttagtgtttt atagcgtcca tgttttaaac tagaacggca aaatagtagt 338161 tgttgtaaac gcttattttc gagacatcag gtaaaaagga tagttaaatc ttacaatcaa 338221 tgcatgtagt gagtggcgtt tatcaatagt ttttaacaat tcccattttg aaagaagccc 338281 acaacaaccc tagtagttcg ttaatatacg ttatgatggt caagtgtcac agtacggaaa 338341 gcttgcaaac agctcttaca tagaggagtt gcttcaaaat aaacgtcctc tggtgtcaag 338401 tgtctcatac agcgaccaca tgcgaaagaa actactacag ataagcaaat acacaaatta 338461 taatcgtgga ttcatcatca gaatacgcct ggccctgtaa tcctttggct caccaacatt 338521 cgatggacac ctttatatct tctaataaca gtgaataata gacacaatac gaagaaaaac 338581 ccagcggtaa ccatgtaaac ggtaccactt acgccataag ctaaatagat cagaatggta 338641 gagactttga caaatagctc gaaagcttta gcgaacatta gtcttatcca atttaagttg 338701 ggttcattgc catctctact tttcataata tgttttatca caggtgaaga gtaaaataca 338761 atgatgttat gaaactttcc aagcaaccct aatttaccag tatccttata tgctattaat 338821 gtcgtgccac cagaaccaaa tatcttggca aatttccagt atcccacgat ttcgattata 338881 aaatcattct ctgaaaaggt cattgaattg aacccgctcc ttaatatgtt gtatacggaa 338941 aatgggaata aaattagccc aataaagtaa tctaaaatga ataaatttct aagaaaagtt 339001 ctgagagggc tctgctgcct tgctgtgaat ggggaatcgg ccgtattggc gttggtggct 339061 cttatagtgt ctgcattgat tcctccattt ccgtttgtgg ttgcatccat attagctgct 339121 ctatttatat ttgaagtaga actcatattc ctcctaaggg agttaaatat tccatcgatt 339181 gcttgctgta catcctgctg tagttcttgc tgagattgct cggttacagg tgaaggctct 339241 ctactatgcc tcgtttccga ttcttctaga aatcgctgaa acagataatc atcattatcg 339301 tctctttctg tccaattact gcggcgatga ttttgaggcc tcgccatttt ttctcactaa 339361 atgcttgtga ggatgtatgc gtttgattcg gtgtctcttt aatcatattc ccgaatcgac 339421 cctatttgaa ggtagaggga gttgtttcct ctcactattg ttataaaaga tcatcaatga 339481 cggaaactaa tatgcaatga aaaaatgaga agtttacatg aatatgaaga ttaactgcac 339541 agcaatgttg ttgacccttg gtattcgcac acactaagcc aacataggtt cgttcaattt 339601 ttaaaaagaa gatggtccgg cctcagaatg ttcactggtt tatcgctaca attgtatttt 339661 tcatcggatt tgtacacgct aatacagaat caatcttata taaggttcct cacaactttc 339721 ccctcaaaaa accaagagac agctctactt atgcaagaga tgtaaacttg atatcttcca 339781 tatcactatc gggagaagca atgagtcaga tcactatcga ggccaatacc actgacttgg 339841 agttgcataa tactacgtat attgaactgg cggacttaca gcgagacgaa acatatcaga 339901 ttaaagtgtg ttggtcagca atacatccaa tttccattaa taatctccaa actatcacaa 339961 taccacgttt cactgaattt cagggaacta agtcagacta cgcgagaata ctagtgactt 340021 tccaggtctt gtctgactcg tatcctagtg agcatgccat ggttccaata caagtctcat 340081 taatcaccac tcggctaggt atccccgtgg atatttaccc aacattaatc gttatggtgc 340141 tattagtagc agggcttgtt gttacccggg caccacacgt attgaacgat cttttgctga 340201 aattttagta tggaagcctg agcccccttt ggctggatag cttggcctca tcacaactag 340261 aacgtaaaaa agtccattaa ccatcaaatg cttctcatta aagtgggtat ttttatcgaa 340321 agaaagggac ctgaatatct aactcgccgc tatgtcgaat gaaaacttat ctcccaatag 340381 tagtaaccca gatttaacta aactgaataa cggcgaaagc ggaactattg ataccagcaa 340441 attctcgccc aacgaaatga agctatacaa aatgtacgga aagctgccat caaagaaaga 340501 tatttttaag cataccatgc agaaaagaaa atatttcgac agtggtgatt acgctttgca 340561 gaaagctggc attcaaaaca atgatccaat aaactatgga aagaataacc tgccattaac 340621 aaatcccagc aaactacgag aagatataat aaaaagaagg ataagcactt gtccgtcaac 340681 tgcctcaacc gctggtgtag tagataatgc gacgttgata caaaaggagg gaagtatatc 340741 gagtggacca ccatcgtcta ataacggtac tattggaggt ggtagtacaa gttcaacgcc 340801 agtggggaac cacagctctt cgtcgtccag tttgtatact gaatcaccca ttagataaat 340861 agacaacctg tactttttta tattttttta gggaaagaga agggtctctt atatttaacg 340921 cttattatgt gatttctcga aatgtcaagt gttacagcca tatggctgac tgtgtttacg 340981 ttaattagtt atatataaac gataagccat tctgatgtta tcttcttgta cttctaatta 341041 ataatattta ctcgtcagaa tttcgacttt aatgagaata tagatatctt cctagttttc 341101 caaacattag agaaccaagg aaataaaaat ccatgaaata taaaaattgg gaaccgtcga 341161 taatatcttt gtagcaagag atacaacaac ccaccccaat gcagatgcag ctcattaaca 341221 tggatattga gccgtcaaaa aacaaccaca gtataatatt cagaagcccc catgcccctg 341281 ccgcctgcaa agaggagttc cactgtattt tcctgatccc aaatgtgact cccaacatgg 341341 cattgatact tctaataaca gaggtcaaac tgtcatggtg gacagagctc ttaacaacct 341401 ctgtttgaaa aatattatcc agaattggta caacagaacc aaataacagt ccttcaacac 341461 cgtagcctaa ccagtttggc agaaccccat tggatagcca gttacaaagt ttgacaccca 341521 gtagaagggg tctcgatgca aaatctggat gtaagagatg attatcgtgc aagtttctgg 341581 acagttcatg atatgcgaaa ccgctcaatg acaaaattaa tacagcttgc aggtaatgaa 341641 gaatattttg acgagtttgt ctggttcttg acggaaagtt ttcgtgaatg gatgatgctg 341701 ataaaatcct ttccaaatta ttagaagata ctgtgttcct tggcagcgag ccgccaacct 341761 tatgggccaa gtaaaaagtc gaatcaatag tttgatctct actatatttg gtagaatcta 341821 tagagacaga gcgtttcaat tcttcgtaaa tttcgttatc ttccgatctc acgacgtcat 341881 catcatataa tgaataaagc tgcggtttag tcagagagca gattgattcg gtgctcttct 341941 ttggatccgg ttctcctcta ttggccattc tgtatgctgt tttctttgag aaatactttg 342001 tcgtttatct tcgtccttgt cttctttttg gtcctttgtg tttgagtgct ttccaaactt 342061 tttctttacc ttttgcacgc caactactat gccctttatt gcaaataaaa taggtactac 342121 aataagccct atcatcaatg ttgagctgtc aactagaagt ttaaggaaaa gaacatctcg 342181 aagtttagta atttccttgc tttcatattt taaatgtcta gctaatttcg tatctaccct 342241 ttatctcatg ccgataaaaa gaaaagttcc cccctcgtgg ccagcgacgt tcgtatatac 342301 ataaaactgc ctcaccctcc tttcggtggc aaaagcatgt tctacaaatg agtataaaga 342361 tgtaataaga gcttgtacaa gcaaggactc gagctagggc ggaagtgtga caacagtgag 342421 ctataggcac attgtagtgt acatctactg caagagcttg cattaatttt gatataaaaa 342481 aaaggaccat caactaattt ttgctatatt taagaatgtc ggcggctatc gaaaaagaaa 342541 ccggaatgtt ggatgtagga aagcactgtg catattgtag acaactagac ttcctacctt 342601 tccattgttc gttttgcaat gaagatttct gctcgaacca tagacttaag gaagatcacc 342661 actgtaggtg gttgctagag catgaagaag ttcataaaac tgaaaaaagt cctagcaaaa 342721 gccgggatgg ctcaagttct aacgatgaag catatttcaa gagtctgtta cctgagaggg 342781 ccagtgttag aatccagaga gtaagtgaaa caagagagcc tttgagaggt tctaacactg 342841 ccaaagtgag ctctactttg aactcaaaga cattagacaa aatatttaag ttcttccaaa 342901 ggaatgagaa aagaaagagc aataacaaat caaaaaagaa tttcggttcc tcgtcgaata 342961 agataattca attggctaat ctcaagaaaa ttgctaaagg tgaccccaag attcctatgc 343021 aaaataggat ttacatttgg tgttacttgg tggatggtga tgagacggat atagccaagg 343081 aggatacaag aatgccatta tacattaaca aaatgtggcc tgtgggtagg gccatggact 343141 atttgtctat ccagctaaac gtgaaatcta gcacactaac taattcaagt tctaatgaca 343201 aatttcaact atgcaaattg aaagagggta aacaagtttc attttataat attggcgctt 343261 ccttaagagt cactaatgag atcaaagatc ttgatactct gtatttagta cacaataacg 343321 ccgacgaaaa atctaattaa gaaggacact ataaataaca aacaatcgcg cggaacgtca 343381 agcgtatata ctatataaaa agaaaacaaa aaaaatcaat aacccattaa agatacataa 343441 tcaataaaaa acgatattaa aaagcacgta aagtacttaa tattttttta ataatagaca 343501 ttttcgccct tactttttaa ataaaaaaca taaaaaaata tcaaatgtac atcaaaatca 343561 taatactaga acaaaatgtg aagatcactg gacggtggtg ggaatgatta caaaaaacct 343621 cctccgtttt ctattctaac agcatcctag cttactgaaa aaacctttcg atgatttgtt 343681 actatttcta tcttgcgctg cgtttttagc gttttgttcg tcgttcgccg ttggttgcgc 343741 attatatgga tacttgttag tttgaccatt ggcacctgta ttggcaaact gtttggattt 343801 ctgttgcatt tgcttttgtt gttgctgagc atatttttgt tgagtttgtt gctgatatgc 343861 ttcatacgaa gttggatcaa gcttcgacgc ctctctttct tcgtcatagt gcgagtcatc 343921 tggttgtaat tgataacgat tggcctgttg ctgggcctgg gcttgttgca attgttgttg 343981 ctgcactttg gcttgtgctt gagcctgtgc ttgagcctga gcctgctgtt gttgttgctg 344041 ttgattgtaa tgatggtgat gatcgggtga tgaatattga tggtttttac ttctatgcct 344101 ttttgatttt tcatttggtg gatttgggtg accataacca tgtaagttcg gctttttgtt 344161 tatcgacaaa tcccaaccac ggccaccatt cagcttcatc caatcatatt gtccatctgc 344221 tgtttcacct aaatcatcca acacagataa aagtaacatg cggtagccct cataatcagg 344281 agtttcctca aacgataaat ttctgactat ttccaaatac ctaccaaatt ggattgggag 344341 accctgagct aaatcgtaaa catttgttag tcttttcttt tcgccaattt tttcgtactt 344401 ttgcttgtta tttggtgctt tcaaaccttg ccatggtagc tgccccctca agaaataaaa 344461 gaagacatga cccatagctt ccatatcgtc tcttctcgat tgttctctac ccaaatgtgt 344521 atttatcgac atgtatcttg ctgtgccact taatgatttc ttttccctgt acggaatatg 344581 ttgtttagtt tttggatcac gatattgttt ggccatacca aagtcaatta gatgaacttt 344641 gttagcatct ggttgacccg gtcttccgat caaaaaatta tcaggtttaa tatcacggta 344701 tatcaaatca tgagcgtgca aatcttcaat taaagttatc atttgtactg cgacttgtac 344761 aacagttttt accgaaaatc ttcttccaca ccaatcgaat aaatcttcta aagaaggacc 344821 aagcagatca ataaccaata tgttatgtaa tccttcctga ccaaagtagt attcttgtgg 344881 tataccaggt gttcccgcta aaattttata ggtccgatat tcgtccttta gctgtggggc 344941 ttctgttttt cttggttcaa acttgatagc aactggtaat ccattgatca tgtttgtacc 345001 ttcaaaaagt acaccaaatg aaccttcacc gattttctta cctatcttat agtgcagccc 345061 gactatagtg gaatcgtcgc gtgattgtga gccagaatag gaggcagagc tattgccagt 345121 gttgtgattt aggttagagc taacatgtaa ggatgggggt aaagtaccat tgaccaatct 345181 aacattgcta cggttaggca tttgtgagtt cattgtgtta ttattgacag ctaaaccaga 345241 gttcgttgct gtcaaaggac tttgcacttg agacattttt ggaaaactat tttcttggct 345301 tatatgctgt gttcagtaga aacaacaagt tttgtctatc aaaatggaga aaaaaacttt 345361 ctaatatgat ctgcacagaa acacgaaaca caaccacgtt cttaaatctc gaaagagaaa 345421 aacaatatca aacgaaagaa gtaatttccg taaagaaact ctttttttct gtctgaaaaa 345481 aaaggtactt aggaatatat gcggattaca aaggtataca aaaaaaactc tatctcatac 345541 acaataactt aaacttgctt tttattatca tgttctttac ttttctttaa tttccctcct 345601 gaaaaaatta aaaatttttc attactcatt ttgtggagac acccacagcc cacactttaa 345661 tgagtgttct aacgttcaag gttgatatta tcaccaaatt tagcatacag gatcgccttc 345721 agagcatcaa gacgggaatc aatgtctctt tgcttgtcct ctaaagtctc tattttgttg 345781 tcgagacgtt ctgcgtcttt ttcgagctgt gcggtaactt tgctctgttt catgaagata 345841 aagaggtcgc ccaccttgta ttgcacgggc tcatcttcgt caatcaattc aatttctaga 345901 gacacatcat cgaggtactc cttctcctcc ctctgtaaac tcaattcctg cgcaatggcg 345961 tccttacgca taatcaactt cgaaaactcg ttgatctttt gctgatcttc gaacgttacc 346021 tgagtgttgt tcctttgtcc ctgtggtaac agttccataa tggtcctctg ttagtttctt 346081 ggcgttgtgt attctggtag tttccgcagg accaaacaga gcataagtcc tctaagtact 346141 tagcttcctg taaaattgta tgaaaagccg cctctgctga tcatgaatga cggcctagcg 346201 ttcctcatat gatttagata aaaacataga aaggtatgtt aatagtacga gagaattcgg 346261 agaccttagg tttcacaact ggaattgggt taactcgttg agtcactgtc gaatgtccga 346321 agaagtatgg aatggaaacc aaggaatcct ctccgtatat gtgagcaaag ctagagactt 346381 gcctaatttg aataaactgg acaagcaaaa tgtaatgctt aggttgcgaa tagctcatat 346441 gacaagagcc agcaacactc tacatcgagc aggtcaaaac cctgttttcc attatttaga 346501 aaaatttgat attactccag agataaagcc tttaatgtac gtcgaagttt actgcgatag 346561 aaggaaaaaa tctccgctgc caattggaag atgtgaaata gaccttttaa atgctattag 346621 agcagacccg aaggagggtt attgtacctg gtacgaactg aaaagaagtg gggatgaatt 346681 tgctggcact atattcattg agttgacttt cactcccaaa gtacctcgtt taaacaggga 346741 cgatcttaac aaagaaatgg acaggttgga ttcatctatg gctatgaggc cgataccacc 346801 attgccaaca gaatcagagt atgactatgt tcatggttct acgatgagac agattactcc 346861 ccagtgtgtt agcacaagtc acgaggataa ggatgaggga cagccctaca gaaatggcaa 346921 tgttttctcc atgtcatcta aatcagatac agcggtattg gcaaatagta atgacccaat 346981 aattttacct ccaacttttt cagcatccat gggtacaacg tctacattag aaactaatga 347041 tactgctata tcaaacactt cgaatacaaa attccatttt gccaatttaa ggaaattaaa 347101 ggagaagata aatatattta agaatcctga tagttcaaca aacaactgcc aaaatgaatc 347161 taacaaggta gatattgagg cacttcaaaa ggctattggt gtaacttcgt tgtcttacga 347221 cgaagatgat gacgatgacg acgaaaatga cgcattttat tcttccagcc atagagtctc 347281 ccacaactat aaccaaccgc ccttacctcc tataccgacc agagatgata tgtccaatta 347341 ttcaagttcg cgcaatacgc cgttagtaag aagagataga ccctcacgcc tagattcctc 347401 ttcgcctaac tcacatcctc atccatcagg cctgaattct ccaaaactac cacctctacc 347461 gactacttcg aattccaatt ttaattcgag gaagaattcg atgtctccta caagaaaaag 347521 accacctcca aggctcagct aatgacaaga gaaacatgct gttattgtaa tactaatatt 347581 taaatagaat taagattttt aatgtttacc aagatttttt cttttttaaa ttttattatt 347641 tcaatatgta tacataaatc tgttgcgccc tcaccgccga tctaaaccat aaagaaaaat 347701 gctaattgta caaattctgc tttgaagaat atccaaaaat atggtaaagc ggtataaatt 347761 ttcaactaaa aggcggcctc ttcatttgga tcctcttcat caccgtaatc atcatcgtca 347821 ccattgttga aatacttttc agcattataa tcatcatcat cttcttcgtc ttcatcttct 347881 tcgaaatcat catccgccaa atcatcatct tctccttcgc ctgttttact tccttttgct 347941 gccccatcac ccgtcgacgc atcatccaca tcttctgcca actcctttaa ctttgccagc 348001 atggatagtc cgatgttttc atcttgtaaa cctgtaccag taaaaacatc atcggcatta 348061 ttaaacttgg agattgccaa taattttttc ttgttgatcc ccattacatt gtacaattca 348121 ttgggaaaga ggttcaaatt atacggatga tcatcaatag aaatacctat tttccttttt 348181 ttcaaatatt tatcggaata tctttcaatg ccatcattag tatcgtcttc gtctaggatt 348241 atgttgggtt tgcgtttacc gctcttgctg ttttcctgtt gatctattat caagctcatt 348301 gatccggtat aaaatgggcc atctttaaca gtctttccaa aattgatgta ctttactgct 348361 aaagatcttt ccttatttgt tataggacca ttgatgggca atgggatgga tggaaattcc 348421 gtaatatgat ttttgcctac atctccataa cctaatccga agggtagatt gctcatatag 348481 ttgctcccgc cacctctact gccgccccta taagaactca tgtttgttcg gggtatatat 348541 gctcggtact atcaagttac aatatctttc tgtcgtgttg ttttctatag gttgctgcga 348601 tgaggaaact attttcttct ttgagatttt ttcaaatttc tcttcatttt tcatgcggcc 348661 gcacaagagt tgaaaccact gacgaaagca atttcagttc attgagttac acctagcgag 348721 gcacttcttt gtggaatggt agccattgta ttgagatttt tcttgtcgac catcagcctt 348781 tttcttcata agagaaaaga agatctcgtt catgactgct aattactttg aacgatcacc 348841 tctgcaatgt gacatttgtt cgaaagccgc ccattagtat tgaaaataat ttatattttc 348901 aattggctag actacgaaat ttggacaagc cattgctgcg taatcctttc tcttctacgt 348961 cacagtacat ctctttaaac cttttcgttt ctcggctgtt taaggaaagt atcgtcttgc 349021 cgtatctaca taaatcaatt cttacccatt ttcttttgca ttctagccgt taattcacgg 349081 cttagtcgtt tgatatcgtg tttgaattgt gaattgcatc attcatgcgg aatgggaatc 349141 atcgcagtcg ttatccgtct cacaaacgtc ggcatttgct gactattaag gcgacacgta 349201 acctacaaac tcaatttgag acgcaaacgc aagttgatta gacgttgaga atgatgcaag 349261 tagcaacatc ggtaatggtt agactatttt atcagaaaac tatagaaaaa ctaaaaacaa 349321 aacaatgtca caatgacaaa gaggaaccca tacatacaca gagagcctat tcttccagta 349381 gttcctcaat atcagcatca ctatctgggt ccaacccttg gtttcttctc ttagcctctt 349441 ccaaagcgtt ttcaaacaac tcctgttgtc ttttaactct tcttctagtt ttcttacccc 349501 aaccgaaaga agttgtttct gctgttgcag catcatctgg cttgtcgatc aggtcttttg 349561 atctcttttc ctctttgtct cgtttgtcct tttccacttg ggcagccaac tgcttcttcg 349621 ccaattccct ggatgcgata tttcttaaga gtaaataacc acctacaatt atcaccaatc 349681 ttataaagtg cttgtagtca tagttgacta gttttgccat ccaggtatcc acccatgttt 349741 ccgctacttc agacatctct ttcaattact cggcagtttt tctcttcata acatcttttc 349801 ctcatacaaa ccgccgagtg cacataaata caactacaaa taataatatg ttgacatcgg 349861 atggagatca ctaactaaac cgccaccgcg ctaattctgc acaaattcaa atttcatcat 349921 cgctctccac gtcatcatgg acgtcttcca cctcggcgga ttcttcgtct tttgatagaa 349981 tttccacagc ccgcggacgc acaaacgatc cgtgacccgg cgccacaggc ccaaacagtg 350041 ttaccccatt tatgcgccca tcgtttttgc ctgcggcttc cgggaattcc acaccgcacc 350101 atgtgcccat cacgtccaac ggtagtggtc ctacgtaccg taaaatggcc tcacgtggag 350161 cgctcccgtc tactgtgaca cgacagtggc ggccgatagc cgccgttaat tgctctcggg 350221 catatgcttc gtcctgcttt gccagcgcag cgcgctggct ctgctgtgca gcattaaacc 350281 taccatagcc gtgagccatc ttccatcgta atacggattg atcccttcgc aaataatcct 350341 cctcgctaat tacttccatt gaggggattc cttccgcttg cgtggccagc tggttagaga 350401 ttgattgggc attagagtct gtaacaacca caataagctc ctcctctcct tttaggaagt 350461 tggcatcttc atcctcattt gaataggcac cccccttttt agtactatat atctccttgt 350521 tgtcgtactg tcttttcaca actatttcca tatcctctgg ttccactccg gtaacatggt 350581 acaatcggtc cttgaactgc cttaatttaa gcgaatttgg taattccttt tctgtacgga 350641 ccaattcact ctctatgaca actctaacca tagttttgcc atgtaatttt tttttctatc 350701 tctttatttg aattcgttgc tctatgttct tgtcgcttgt cttcttcaac tgccgtttcc 350761 ctgcgagccg gaaaaaagta ctgttctttc gaacaaaggc gaaaaaagct gtagctgaaa 350821 acagacaact gggaaacgac aattaagaat acgcatgtac gtgtatacta ctacagtaaa 350881 aaagaaagtt atttgagagc agcactttgt ttactacaca gaacattaac caaaaaaaca 350941 tgcatcagca acactccgta tgtttcactt cttattttct tccgtggcaa taaccttcct 351001 tttgacttat ttatactaac attataataa ctatgtttcc tttttgaact aagaaatcag 351061 agaacaaacc acaacagcaa aggaaaaaat tcgaaggccc taaaagagaa gctattctgg 351121 atttagcgaa gtataaagat tctaaaattc gcgtcaaatt aatgggtggt aaattagtta 351181 taggtgtcct aaaaggctat gatcaactga tgaacttggt acttgatgat acagtagaat 351241 atatgtctaa tcctgatgat gaaaacaaca ctgaactgat ttctaaaaac gcaagaaagc 351301 taggtttgac cgtcataaga ggtactattt tggtctcttt aagttccgcc gaaggttctg 351361 atgtactata tatgcaaaaa taggtttaat aatataatct catataaact cccttcctta 351421 cagttgaaaa caaaatcaaa tcacggtatg gcatttcttt acatattctc aatacctgac 351481 tgacatagta tgcgctacat agttttgtcc tatttttttt acaccgcgat ttgaagtcta 351541 aagccagaga atgaggaaaa acgaaacaaa ctgagatcat ttgtataagg ggagtcactg 351601 tacagctgcc aataccaatt ttccttctgc caaatcaaaa aagtatccgc atacacatac 351661 acccctccct ctacaatctt aattatttac tgattccttt cgtatttgtc cagtatgagc 351721 aatactaagc ataccacttc tcatcacatg gaactcaaaa ggatcattat ccttacactt 351781 ttattcatac tcataatgtt gatatttcga aactcagtgt ccttcaaaat gacatttcaa 351841 gaactactgc cacgatttta caaaaagaat tcaaactcag ttagtaataa taacaggccc 351901 tcatctattt tctcggaaaa cttggtggat tttgatgatg ttaacatggt cgataagacc 351961 agactgttta tttttttatt tttcagtttc atcattacta taccgtttat ggtataaatt 352021 agaaaagtta aagcagcatg ttttcatttg aaacaaatac taatgcaata ataggtacac 352081 catctactac ataattaatt gatagtttcc ttttccgtta agtgcatgca taggacgccc 352141 ataatttttt aagttaaaaa agcatgtatt tacctattcg ggaaatttac atgacatgga 352201 tgccataagg aacgaaaatg aaacatgcat gtcagaggaa aaagaacaaa gcgagaggaa 352261 aaagctgttg cattaccacg taattttgta tataaatatc tgataaataa ccattttatt 352321 tccatccact tcttctgtcg ttcatccgtt cattgacatc actagagaca ccagcgagct 352381 atcatcttca tacaacaata actaccaacc ttaatgcaac cgatcaccac tgcttccaca 352441 caagccactc agaaggataa atcctctgaa aagaaagaca actatataat caagggcctc 352501 ttctgggatc ccgcctgtgt tatcgcttaa tttttgacga caaccaagag gtcaaatcaa 352561 tatctaccct ttcatttatt acgtgttgct ggcaaactaa tttattccaa ttctctcatc 352621 attagctcac cctttccata ctttttcata cttttataca tatgtatttg tagttatcac 352681 tttaacagat tttttcatgt ttttcttttc tgatacgcct ttccctccgc aggaaatgaa 352741 agatgaacca cccattacat tcgatttttt ttttaattat atttttgact attatttaat 352801 cattaaaaac acatatattt cataaattcg taaggtcgtt agttctatcg taaaagtgaa 352861 aaagttttga gccagttttc aaaaacccgc aggatcccac tatgtatggc tttaaataat 352921 ggtttttcac gtgcatcaag tccgtactat cttcaccact ataaactctt ataggtggat 352981 tattcgtttc gaatgctggt ggcagtgccg gtttgaaaat aatcttacct acccatgggt 353041 ggtcttccgt taacggtttg atgcatctta atgagtcttt gatatatctt ttccttgaaa 353101 ctagttgtgt cgccggtgcc cacttcgaat cgttactgga ttgattctta tttccacatt 353161 ttagtgacaa tttctttgga aaatcatgat ttaaacaacc agtcacggaa aagcttttcg 353221 tactgaatat tgtaccgtac tcaacgtccg cattctcata gcgagattct ctttcatcca 353281 aatataccaa tctattgatg tcatcatcct caacatatcc atcttcatca tcctcttcgt 353341 aattagcatc gtcttcgtct tcgtcatcat cttcatctcc atttacatct tcattgccac 353401 ggtttaactt ttcttcacga ttcgtacgct cagcagaatt cgaaatagtt gaccttcctg 353461 ttccctcgta taccggttca aaattattaa ttttcaacac tgaccgatca cagcgcaaag 353521 gatctatagg gttggaattc gatctacttc tgaagttttc atggatggat gtttgtgccg 353581 ttaaaacaga atgtgctgtg ggagaaaaag tggaagatag aacagaagta ttggtattag 353641 tagtactacc attgtcatcg atttcttctt gaacactatt cagttccttc gatctcattt 353701 tttgtccaat gtccatatta gagttttttc tcgaactgga atctgtttta aagaaatttc 353761 ttagttttga tgtaaataag ccacaaaaat cagtttgaga actctcccct gccaatgaac 353821 cagagtcatt gggcccattg gagtcatgac tcgcatcgga tacagaggga ggtagcaagc 353881 ttaaacttct tgatcttgat ttgtttgtcg gacgttcgtt gccggtggcc acttttgtta 353941 caacagaaga ggtgtgtgat cttcttaaaa gtaaagagtg ggagcgagaa tcatttctat 354001 cactattttg tctgctcttg tttttgtttt tgttcttatt gtgttgctta aatcttcttg 354061 ccctcggatg tctccttctg ggaacgcttc tataggtggg catttccctc aattccagat 354121 ccaaggacag ggatataccc atgttcaaat acatagccca atagatcaat tcgtctacat 354181 gagaaaactg cactagaaac tgttgtccct cacaacgcat tcttaaaaca aaatctctag 354241 aggaataatc tataggcaga ccaactttgg cacattgcag ggagtaactc ttaaagaggc 354301 gctcatctga taaaaatttg tgctcgtctc gtgctatttc cccgcatatc ctttccttgt 354361 catatttatc gaattggtaa gtggatttcg tcgtgaacgc atttaataac gaccgagccg 354421 aatgatggcg atcgctagca gttttggaat ggtgggaatg gtcaaacatg tcaccaccac 354481 gatagttttt aatatgcctg gttaatgaat cgtcaataga ataaaagttt atctgcgtag 354541 agtttatttg aagaataaag ttgttccata atcgagaaga agcattttca aagggcgata 354601 gtttttccat cttcatagaa accacagtat agtgttctac agacggtgta taactgggag 354661 gtttcacaga agtgaggcac ggacgacaat gctcatatat agggtaccta atgactttag 354721 acggattcgc aaaatcataa cacggaggtt ccactgggta cggatctatg cagtaaagca 354781 cgtttttgtc agcaacatca acatctactc cggattgtgg ctccactatt tcgttcatga 354841 tgtttgtgtt aatgtctgtt atgctatcga tatggttaaa agtcactttc ggaagcggag 354901 aatccagaat agaattacta gtagtactgg aacaaagaaa ctcgtcgccc atggatatgg 354961 atgaggctgt ctgtgaaagc ttcagccccg tactatccat accgtcgtgg tctattgtca 355021 tttcaaagat gctggaggac attttctgaa taggtccgtt tatctcttct gctgtctgcg 355081 aaaacaacgt aaaaaaatag tgcttagtgt tactgcctgt gtaacaacta gtgccaaagt 355141 tacaaagaaa cttcactaac agtttttgca atttaccaag aaagcaccaa caaaataaat 355201 aaatagcatg cctgtatata ttacgaaaag tccttcaact acgtcttcca cttgctctat 355261 cccttggcgg aaaacagaat acatgcaaat tttagagaat ttttcaagat gcctgccccc 355321 cacattttct tacttgatca agagcagatc tgttcctttg cgcagggggt tgcatggggg 355381 agaaactggc cggaagcagc cgaaagaaag ttcgcaaaaa gataatgggg acagtattag 355441 agaaaacggc gtggaggggt atggaggaaa cagttagcat aggtaacgaa aaaccgcagc 355501 aaaataattc tctctttttt tcttttgact tagttgtggg acccggatca ttcggtactg 355561 catcttattc ccgtgccaag gtctctgggt gttgctgatt tccgggtatc cagagctcta 355621 tctgcttccg tacccagtga gtgagctaaa ataaaaaagg ggcctcggcg gaatttgaat 355681 tcgggttacg tttcccacgg agccccggat agaaaagatt agtttcaggt acatgtgtca 355741 aatgaggata aatctcaaac acccatgtac cgaaaatcga tgtgttggtt atattacaag 355801 gttggaatag accacggtga taagacgtgg aatttttgac tgaccatgcg actctgaagg 355861 tgttaaccgg aggaattcac gtaatttaca tctcaagaac agcagaacaa agatcgagta 355921 tatgatgaaa tttcgtttta catgaataaa gtcatatttt aactcactgt gcacggatta 355981 agggctgtga tttagtggga cgagtggttc tacactactc aagaagtcac gctgtcattt 356041 gatggaatta cagtgcttat taggagccgt gtagcttagt gtgaattgat ggaagctttc 356101 gagtttcata gaacatatct ggtgaatgta tatgagtttt tcattccttt tacgagacgc 356161 aactttccgc ggttacggaa ctgttgtttt gttttacatc ttttcatttt tcatacattt 356221 tattgaggcg tagaaatgaa atgggtagag cggcacatgg atgtaacaat ctccattatt 356281 cacgtcgagc cgatacccgc ttctgttgac gctctgttaa gcatagaacc tacgagattt 356341 gtgctaaagg acgttggcaa ggaagaaaac tattgttgat gacaggattt atagcagtaa 356401 atattttttt cttttttgcg aaattatgta cgtttctcat ccaagaagaa tcctgttaat 356461 atttaaattt ctgctagtca ttatcatatt gcaatggctt ttattagtga aagccactgt 356521 caacagtaac tgagctactc cctccaatgt tgtctaactc tatgctcttt ttggcgtctg 356581 aatgagccat aacgagggaa ataactgtat caggaatact aacagaatac agattggatg 356641 cactggtgct ggtgagtttt ctttttctga tattattgga taatattttc agctatagac 356701 tatcatcatt cagcattggt cacgctaaaa tatacgttcc atgcatacgt gatagcctac 356761 tcggttgtca acttcatttt ataggctgcc tggtcaccga ttaccgcccc gctcagcagg 356821 acggtttaag cttctgttct tggaaacgac gtaattcatg tcggccatcg aaatcattcc 356881 tggctttgta atagtcataa tgaacaagga atgctgtctt gggttttttt ccctttgcga 356941 atacccgggc tgccaaaata gaaaaggaac aaatggtagg tctttaagat aagaaagata 357001 agataagaca tctttttttt tttttttttt tttttttttt ttttccgata acaaagaaga 357061 atccttcggt ctcttcttac tgctgttact gcttatcaag agtgtctggt aatagtcaaa 357121 gccagataag ataagaaatg taaaatcgac tatttccctc gtaaaaagct tcaattgctc 357181 acgcatcgac gaatactaag cggcgtgaag accctgtgcc ttatcaatga agtattcagt 357241 acaagaggtg ttcattccga gccacttttc tgcaccatat ataagcagta gttacacatg 357301 tgctaaccaa acatcagtgg gtagtaatca ttcgtgcttt cacgtccttt caaattaaat 357361 atccttctta aataataagt ctgcacagag ctttgaaaga agtttagttt tgtaatatat 357421 catacttaat atattacaat acaatatcaa caatgtctta caattttaca ggtacgccta 357481 caggcgaagg aacgggtggt aactcgttga caacagattt gaatacacaa tttgacttgg 357541 ccaacatggg atggatcggt gtggcttcag caggtgtgtg gattatggtc ccaggtatcg 357601 gtttattata ttctggttta tccaggaaaa agcatgcttt atccttgctt tgggcctcga 357661 tgatggcttc cgccgtgtgt attttccaat ggtttttctg gggatactca ttagctttct 357721 cacacaacac tagaggtaac ggttttattg gtaccttgga attctttggg tttcgtaacg 357781 ttttaggagc cccatctagt gtcagttctc ttcccgatat actgtttgcc gtttaccaag 357841 gtatgtttgc cgcagtcacc ggtgccctaa tgctaggtgg tgcctgcgag agggcaaggt 357901 tgtttcctat gatggtgttc ttgtttttat ggatgactat tgtttattgt cctattgcat 357961 gctgggtctg gaatgccgag ggttggttgg tcaaattggg tagcttggac tatgcaggtg 358021 gtttatgtgt ccatttaaca tctggacatg gtggtctagt ttacgctttg atactgggta 358081 agcgtaatga ccctgttaca cgtaaaggga tgcccaagta caaaccacat tccgtcacct 358141 cggtggtttt aggcacagtg ttcttatggt ttggttggat gttctttaac ggaggctctg 358201 caggtaatgc aactatacga gcatggtact ctattatgtc cacaaactta gctgctgctt 358261 gcggtggctt gacatggatg gttatcgatt atttcagatg cggaagaaag tggactacag 358321 ttggtttgtg ttcaggtatc atcgctggcc tagtgggtat caccccagcc gccgggttcg 358381 tgccaatctg gtcagccgtt gtcattggtg tggttactgg tgcaggatgt aaccttgctg 358441 ttgacttaaa gagtctattg cgcatcgatg atggtctaga ttgttactct atccatggtg 358501 tgggtggttg tattggttct gtattaactg gtatctttgc tgcagactat gtaaatgcca 358561 ctgcaggctc ttacattagt ccaattgatg gtggctggat caatcatcac tataaacaag 358621 ttggttatca attagcaggt atatgcgctg cactagcctg gactgttact gtcacatcta 358681 tcttgcttct aactatgaat gccattccat ttttaaaact aagattaagt gctgatgagg 358741 aagaattagg taccgacgct gctcaaattg gtgaatttac atacgaggaa tccactgctt 358801 acatcccaga accaatcaga tctaaaacat cggcacaaat gccacctcct catgaaaaca 358861 ttgatgataa gattgtgggt aacacagacg cagaaaagaa ttctacgcct tccgacgctt 358921 cttctactaa gaacactgac catatagtat aatgatatac tcaagcagac tatgatttta 358981 tgtttaatct ttatgtaacg cttcatttaa taattttatt tttaatattt gatatatttt 359041 ctttttttga taactccgaa tgatgagggg agacgttagt attacttctc ttgtcttatg 359101 ttattatcat aatcgatgac tttaactgtg cacactataa tatacagcat ctccagagca 359161 tgatagcaag aaattttctt taagaaagcc tctatatacc ctatatatgc tgttaacagg 359221 aaaagagcac aaggtttatt ttgctttggt tgcaaatttt catcgcttat agaagacata 359281 ttttgatgta aaaaccttga tatacttcct ttttgcctta tctttcactg tttccatctc 359341 ttttcttttt tttttttttt tttttttttt tttttttttt tttttttgaa tcttaaaatt 359401 ctcgaaactg cactgaaatg gcgcaggaaa ctgacctcat cgcatgccaa cgaagattga 359461 aaaaaattaa catataaggc ttatgaaagc gacatctttt gcaaatgaat aattgacaag 359521 caggcctgtg tatttatagt tattttgaaa taataactac cattagaact aacaaaagaa 359581 aagaaaaaaa aaataatggt ttctgtggag tttttacagg agttaccaaa atgtgagcat 359641 cacttgcatt tggaaggtac tctagaacct gacctattgt tcccattagc taaaagaaac 359701 gatataattc tacctgaagg ttttcctaaa tcggtcgagg aattaaacga aaagtataag 359761 aagtttcgtg atctgcagga tttcttagat tactattata ttggtactaa tgtcttgatt 359821 agtgaacaag atttctttga tttggcgtgg gcctatttta aaaaagttca caaacaaggc 359881 ttggtccatg ctgaagtgtt ttacgaccct cagtcacata catctagggg catctccata 359941 gaaacagtca ctaaaggttt ccaaagagct tgtgacaaag ccttctctga atttggtatt 360001 acatccaagc taattatgtg tctgttaaga cacattgaac cagaggaatg tttgaaaact 360061 atcgaagaag ctaccccatt tattaaagat ggtactatct ctgccttagg attagattct 360121 gctgagaaac catttccccc acatttattt gttgaatgtt acggaaaggc cgcctcattg 360181 aataaagatt taaaactaac tgcacacgca ggtgaagaag gccccgctca attcgtctcg 360241 gatgctttag acttgttgca agtaacaaga atcgatcacg gtatcaacag tcaatacgac 360301 gaggagttat tggataggtt gtcgcgcgac cagaccatgc taactatttg tcctctctcc 360361 aacgtgaagc tacaagtagt ccaatccgtt tcagagttac cactacaaaa gtttcttgac 360421 agagatgttc cattttcttt aaattctgat gaccccgcct attttggtgg ttatatctta 360481 gatgtctaca ctcaagtttc gaaagatttc ccacactggg accatgaaac atggggtcgt 360541 atcgctaaga acgccattaa aggttcatgg tgtgacgata aaagaaagaa cggtttgtta 360601 agtagagtgg acgaagtagt cactaaatat tcgcattagt accatttgca agacattgta 360661 taatattttt gttgaaagtc tttttcgatt cataagcgct tttttgtaaa tttataacac 360721 tatgtgtatg cacaaatttc attcgatgtt tttgatgctt tttacatccc cttttgtgtg 360781 ggaaaggata caatagaatt ctacaaactt atttgagtga ttatacgagc attagctgga 360841 ccttttgtat ttcacgagat tacaattcgg gaactatcaa agtacacgtt aaaattcagc 360901 tcgggtatgt taagtactag taattacctc tggtacctac tgacgtaatt cccacccttg 360961 ggaccttgcg gaagcgcctg agtattgctc tttctatttc cgttgtacct ttgattttca 361021 ttggctctat gggcagcacc gctatctcgt gtatttctat aatcttgcgt ttgaaatttg 361081 tttctaattg tttcatcctt cttgaatctt ttattcggct tttcttcatt ttctgaaggc 361141 gagtcgcgct tgtaagatga agcttggtaa gggttggctt tgctgctgtc tttgccctct 361201 tgaaatggct tttcaggaaa ccgtaattgt gaacgttgtg aactgttttt cttatactct 361261 tcacgtaagc ggttatccct ttgatcaaaa ccatcgcccc tgtccggacc tgtgggtcta 361321 agtgccctac ttctatcatt atatgtttta cttttactag gtctagttgg tagttctgac 361381 cttttatgtg cataactact gattggctta atatttttgg gtgcagaacg atcattgctt 361441 ggtcctctat agttggaact accataacca tctttgcctc cagcatttcc gctgtaccta 361501 cttgatcttt tggtatattc aggagcagca gcttcagaat atgagctagt cgtatctggg 361561 tatggctcgc gcgagatatt tttaatatac cttttaagcg aatcaatttt ttctgcaaaa 361621 tctggatttt gaggattttg aatgagtgtc ctaaagtacc tttcgaatat ttccaaagtc 361681 gaatttctaa agtcgaatat tggcatattt tgcttagata atttccttaa attccgagtt 361741 tcatcgtcgt tctctactaa ggaaattgcc ttttgtaaat ggttcgtggc caaataatgg 361801 tttatatcgt cgacgtgcct ggtgactttg gaatatgacc attgactact agaaggtttt 361861 gttgggatta caggctcatt acgagaataa gtatatctat ccttgctatt taatccagca 361921 ctgccgcttg caacactttt gggtggatca ttttgaagtc tttgcgactt attaagctct 361981 aactgctttc ttaaagctac ttgcttttgt tcattttggc aagctgtttc ataatttttg 362041 atctcttcta attccatttc acgtattctc ttttgttcag cttcctcttc agttaaggtg 362101 cagaattcgt ccaattctaa agcgtccttc aaacgcgctt tcaaatggcc aatcaatgcg 362161 ctgcttggta gtttaatatc ctccctttct tcatttatca agttttcctc taaagttgtg 362221 taaaccaact ggatatgagc tttcactaca gggaagacac tagtgacgtg cttcatgaat 362281 tcaataccgt ttctaattga catgtaattt ttttcggata aaaggtcaat gacttgctcg 362341 gtaattactg aatgccattc ataaagcttt cgagaagctt ggtcgttgaa atcgccattt 362401 aatctcattt tttcaagctt tttaagaacg tcagtgaaaa acagacctaa attgcctgct 362461 tcagagctag tacaacagaa cagcaacgtt tttaaaatat ttgatgtaat acaagtattc 362521 aatatcgaca tcaaattttc tgtcctaaaa gccataaaga taaaaaacga agagaagaga 362581 gcatctgaag gagaaaataa aacccttggc acaacacaat tctgcaagaa tatcttaatt 362641 tgatcttccc cgcagtcttt gttccagaca tttgattttt cagatataaa ttctgaagtt 362701 ttcttgaagg ctctttgatg cgaaattcca gtaaccaaaa tatccttgat ttgattctga 362761 atcaggtgtt tttttctatt tgacatgtgg cccgtgtttt ctccggatag tgcattctta 362821 cgctcgtcat atagtgattt atcgaaatgg atatcgtata atgaaagtct ccaaaaagta 362881 gtgaaaagat cctttgatat tttcgttaaa tcaacatcgc taaactctgc accttcaatt 362941 aattcatcaa tagaaaaatt ctcatttgag ttcaattgat tatccaagta gtctctccat 363001 atgtggaaag tccacggtgt cgataaatgg aacctattat tcaattctac aaatgggaga 363061 acattctctt caaatgcttt ccctttcaaa caatgtttaa ttaactcaat aaacgaccat 363121 aacaatgtat tcatttcatc gcatctagtg gataaaattt tgtaatgaga attttgcgta 363181 tttgctttca ggtttaaagt gtataacagg agaataatct cagaaatagc gctctgatca 363241 gtgaaaaatg aggttagcct cgacgaaata accgaattat catctctaaa atcatatatg 363301 agatgtcttg catattgctt taatggtgat cctgagttta acattaatag ttgcttcata 363361 ttaacttcgt ttaagtctct aatgcccccg actgtaataa ttaattcctt taggatagaa 363421 actgctatga tattcccatt atgcaacgtc tttaaaatat aggtgattat atttgagata 363481 tccatattgg gacaattttt ggccaaacct gcaataaata ttgataatct ctggacccac 363541 atggcctggt taacaccatc aaattgaaca gcaggcctgt tataagttaa gcgtaacaat 363601 aatacaaatt gcaatacatc atacgcaaaa tcgttaaagt acttcgtggt gtaaacaaca 363661 agctcagaaa ctttgtcata gttttcaatc tgcttaactg ctggtaccag tgaggccaat 363721 ggatttgtag agattaattt ggcaaatctc ctggactctt ttgcgattgt atctatactc 363781 aaagccttca aaatactctt cgcttctctt tcggccttat tgaagctcac cttaagcggt 363841 agaatatctt gggataattt cgtcatcatt tcgttgtaaa taaaatatct tttttcaaaa 363901 gggaaaaatt tcattagttc gtaaacttcc gatgtggcaa ttggattgtt ctgcaatagc 363961 gaggtagctg gaaaaatgaa ttttcttaca tagtctatcc acttatcaat cgtaacatgc 364021 agagactcag aaccgtggtt cttttgaatg tcagctaccc caatacgtga aatcttactc 364081 aaaagcgtag gaattctccc caaatacggt cctatgatag ataaatagat atgcgagttt 364141 tcaaatagat catttacaga agcaaaagga gtcaaattgg aattccactc gctgtaatag 364201 aagacgtagc ttgaattcaa ttcaagggat tcaaatggct cgtgagtttt atatttatgg 364261 atcaaccttg gcttatgggc tagaatacca ttatctatac gggttatcat caaagcagtt 364321 gccatatctt ttgattcacc agatgaggtc attgatgtgt acaatggatt taaaagatat 364381 tcaaatactc ttcccaaata tctagataag gattcactaa catataacac tttcggatat 364441 tgctttaaca catgtatcac gggaataacg caaccatgta tgagtaagcg ttccaagagt 364501 tttattttac caaataataa aatatcttgc tgagttttct gcttgccttt tgattctata 364561 tcagcgtttg tttcctcaga gattttatcc ttcatattaa catcatcatt tacaacaagg 364621 gcgttgtctt cgtcagtttc attttcagtg gacaaagcag ctgccatagc caagggattt 364681 tctacgcctt tagtggactc ctcttccagt tcagtttcta agttttgaat atattcttgt 364741 agaaattcca tctctggttt aacgttatcc caaatagaat aaaaattgac aaacccattt 364801 ttcagtaaaa tgcaacacat atccatatac cgttcatagt tttccttatc gacttcttcg 364861 ttatattgcg ataaattgaa tgaaataatg tttgctgcaa tcatattacc gccttcatta 364921 agagaagaat aattggaatt gttagctaca tggctagatg gccaagaatc cgactttcgt 364981 aaaagagcaa taaagaactt gtacccttca gtgataaact gactagaaac gttcaaaata 365041 acatctaaag tacgaataga atccaaggaa tatttcccca taatatgata gatttctttc 365101 aaatatgcgg acactttgga aaaattgtcg ggatcataat acgccaatat taataaggct 365161 accaattgac cataacccac tgaattttct accaaaaggt tatatttctt cagttcgtat 365221 tttgactttt ttaacaaatg ccttaataag gtggtttgtt ccttgttgag cagcttagag 365281 gatatccaac taaatttgaa caattcttca tgcaacgacg gtattagttt acataatgat 365341 atggttgtta gatcatttat atttggaaca gtgcttgaga cggcgataaa cattttacca 365401 actatggaag cctgggacac ttgcctttca tgattcacta attcattagt aaatgatgca 365461 acatcagaaa gcttgagggg agaattttca tcgtttttat ttatgaaatc aaacagttca 365521 ataaacaaag tcctcaacca gtcttccttt tcatcatttg actccagtgc agtgaaatcg 365581 gagcagagag tttttgatcg ttcaggccag tttcgtatca cctcttccgt taaaatgctt 365641 gcctgactag gggaagctgg tggtatcact ttttgagaaa gagcgttcaa tttggaaagt 365701 agcgtctgtt ctgccataaa gtcctgaaaa tgtatactgg tgcgaatatg tatcaactga 365761 aaccgtttca ccctattatg ctttagataa agacgataaa atcacagccc tataatttat 365821 gcaacagtgt ttgcttctaa atcaacgtgt tccctgggca taaactctca tacgttatgt 365881 cgctattgaa gaaatagcgg aaaatcttac gccgaagtta gcgttgtcac ccgggaagaa 365941 gagaagaaca taagccttct cattcagaac atgtaaatag tggctaaaat ggttatatta 366001 cacaattcga aacagtgaaa ttaagaaaag aaatggtatg ttacgttcta ttgcgcttta 366061 gtttgaattg aaatcatctt taccatggta ctaactacgc ttgcgatgaa tcgtgcaagt 366121 ccgtgcggct tatacgtaat gctaatactc aaaacaggcg gaaaagcaga ggcagttgaa 366181 gttgcagaag atatacaaac aaaagtacat cggactggga gatgagagca ctacacgaga 366241 acagtggcag agaaatgtga gaaacgatac actaaataca ttacaaggcc actccgcatc 366301 tttggagtac gtttcattga gccgaggaga ccttagtata cgtgacactc gtattcacct 366361 cctgaaatcc atgtcccctg gctataaagc ctacttacga gaagagaggt aggacgttga 366421 agccacatcc ataaataatt tttacataaa attacgcctc gtatgtcgtt ctcaagattt 366481 atggtagaga tcacactcag tcagtaacct tttaggcatt gattctagta actgtcgaac 366541 attattaacc ttgatgttta tataaagata taaaatgttg ggacagtata caattcatat 366601 cgtttaaaat gatctataca tgtcgcgtga agtcataaac agggatttag aagtgaaatc 366661 ttttggtagt ataggggaaa actcagcttg aaacttttcg taattgagta ggccaagttg 366721 caaccgtgtg aaatcgaatc atgcctgact ctaagtacac aatgcaaggt tataaccttg 366781 ttaagctatt aaaaaggcta gaagaagcca ctgcaagatt agaggatgtc accatctatc 366841 aagaaggtta tattcagaat aaattggagg catctaaaaa taacaagcct tccgactccg 366901 gggccgatgc gaatactacg aatgaacctt ctgcagaaaa tgctcctgaa gtagaacaag 366961 atccgaaatg cataactgcg ttccaatctt acatcggtga gaatattgat ccgctggtag 367021 aattatcagg aaagatcgac acggtggtct tagatgcttt gcagttgcta aagggaggct 367081 ttcaatcgca attgactttt ttaagagctg ctgtgagatc aagaaaaccg gattattctt 367141 ctcaaacttt cgctgattct ttaagaccta tcaacgaaaa tattataaag ctgggtcaat 367201 tgaaggaatc aaaccgtcaa agcaaatact tcgcatattt gagcgcttta tctgagggtg 367261 ctcctttgtt ctcctgggtt gcagtggaca ctcccgtgtc tatggtcaca gatttcaagg 367321 acgcagcaca gttttggact aatagaattt tgaaagaata cagagagtct gatcctaatg 367381 ctgttgaatg ggttaagaaa tttttggcct ctttcgataa tttgaaagcc tacattaaag 367441 agtatcatac tactggggtt tcctggaaaa aagacggtat ggattttgct gacgcgatgg 367501 cacaatcaac gaagaataca ggtgctactt catctccttc gccagcaagt gctacagcgg 367561 ctccagcacc accacctcct ccaccagccc caccagcttc cgtctttgaa atctctaatg 367621 atacaccagc aacgagtagt gatgctaaca aaggcggtat tggcgcggtc ttcgccgaac 367681 taaatcaggg tgaaaatatc actaagggtt tgaaaaaagt agacaaatcc caacaaactc 367741 acaaaaatcc tgaattacgt caatcctcta cagtttcttc cacaggaagt aaatccggtc 367801 caccaccaag gccaaaaaag ccatcaacat tgaaaactaa gaggcctcct agaaaggaat 367861 tggtaggaaa caaatggttt attgagaatt acgaaaatga aactgaatct ctggttattg 367921 atgcaaataa agatgagtct atcttcatag gtaaatgttc tcaagttctt gttcaaataa 367981 aaggaaaagt taacgctatc tcgttgagtg aaactgagtc atgcagtgtt gttcttgatt 368041 ctagcatttc cggtatggat gtcatcaaat ccaacaagtt tggcattcaa gttaaccatt 368101 ccctacctca aatctccatt gataaatctg acggcggtaa catctattta tccaaggaat 368161 ccttgaatac tgaaatctac acctcgtgct caactgctat taacgtcaac ttaccaatcg 368221 gcgaggacga tgattacgta gaattcccaa tccctgaaca gatgaagcat agcttcgctg 368281 atggtaagtt caaatctgct gttttcgaac atgctggtta atattgcgag gagcattaat 368341 tgtatttagt taaaagaaat aaatcacatt tgaatcaatc agaaagaaaa gtgaatgaat 368401 aaacaattat atactttttg taaaaccttt ttttcatgtg taaccttttc ttaaagaagt 368461 aacaggaaaa cgaggagcga ctaagtgact acttgatcgt tcgagtagaa cttaaaaaca 368521 aaaaaaatta aatatttaca gtgtaaagag aggctgaaga tcagtcaaaa gacgcgtgca 368581 acaatacacg acgatcattt accatttctc aagtaataca tatatgcacg ttcatgaaca 368641 ggaacatcaa atggtgaaat tacttcggat tggcctggtc gagcgacggg atcccttagg 368701 tatacagcgt ggcatgtctt gaaagatatt tccaaatgat gaggtaaaat ggcgaaaggc 368761 gataaaaatg gtcttggctt ccatggtgtg aaaaagggtt ttttaggatc ttgcctacca 368821 taaacataat ttttctgcca cggcaagttt atcaatttac gtgcttttgg ttcatcacct 368881 tccaattcag ataatttaat cggatcatga tattttaaat ttttggccca tttggggtcg 368941 aacgttagtg aaccatcaga aatatcactc atcctagttt tgaagtggtc tgttatattt 369001 ttcgtccata gtttcacgct ttccgctatg attctttttc cagatcttaa agcggatttg 369061 gctccatcag ataattcttt ttttgtggtt tcgttaggat tcatcatttc tgtagccagt 369121 gaaatcaact cgtcaggctg acatttagaa atgatttctc ttctaatttc accggatttg 369181 aaaaactctt gataagcgtt atttagactt tctaacaact gagagtcctg gatctcaggg 369241 agaccctgtt tgagttcatc tatcgacaag ggctcattat tcgacttacc tatttccttc 369301 tctacattta aaagctttct caagatacct tcctgtgtgc atccctttaa tgcgttatat 369361 tgctgtgact ccagattctt attatattgc ctcaaaaatt cttgaaactg aagtttcttt 369421 gggttagaat ccgacatctt ttcaaaattt tccaacttct tctcccaaac ttcctttggc 369481 tccgttttcg cttccttaac atacttgttc cataaaacta tttgagtctt atcgatcttt 369541 agcgcttctt ggaaacttgg tttcttggca ccgagagctt ccagcacttt gtccggtttg 369601 acactgaaca tatctccagg ctttaaagta tagcttggat gcttaatttt tacaccatta 369661 acgcgaacat ttccatgcaa gatgaactga cgagcttgtc ttactgacga agcaaacata 369721 gccctgaaaa gggcaaaatc aagccttttt tctaatactg caaaagtttg taataaaaat 369781 ggtgtttcct tgatttcacc tccacgcagt gaagcatcca attgtgctac tgaatccaat 369841 ttgggtttga aaacggtttg ccatctcttt tctgtcaaat gttcaccatg ataagctcgg 369901 gtttcctgct ttgccgtcca cttctgttga tacaaagatt tagacttcaa gtctacacca 369961 ccctttttgt acaaattaaa caaattatac ttattgaaag aagtgcgtac tcgtcctctt 370021 gccaaagatt ttagcaaatt agcctttctt ggcattatct ctgtatttta attgtaacca 370081 gtcttccgta ccaaaaaagt ataaaggagc tcctactcga tatatattcg aattagttgc 370141 acttcctctg gggaaacctt cacctttttg accgttcgct ctctcttttt gtatatcttc 370201 agcatagttc cttaactaat actgcgaagc gaaacgtatc cggctgccac catgaaaagt 370261 aaaatcgtgc ttaacgaaga aatcaatcat ataatctatg aagatggatt ggcggagttt 370321 attagaagtt gctagctgct agtgaagaaa agggaatcgt ggatgtgatg gtagtacatt 370381 ggacaattgt ggatgaaata cgacttctta gatgggcatc tgaattcaaa ccggccggaa 370441 ttcataagca tttccacatg ttttgcatag tggaaagaat gaattcgcca gataagtatc 370501 cagtgacgct attacagaaa gaaaccatga agttggggaa ggtatttact gcaaaagaca 370561 tatgggataa gttgagccaa tcttacaatt tagagaaaat tgatgaaatg gagaatacat 370621 attccttgga agccactaca gagagttcac ggaatggcaa tggaaatggt gacgatgcag 370681 aaattcatga agaaacttta cttgaattga ataatcgaat aagagtacgc aagcaagatt 370741 ttacattacc ttgggaggaa tacggtgagt tgatcttaga aaatgcaaga aaaagtccaa 370801 actctaacga agagtatcct cgagttgaag atatgaatga gaaagatagt acaattccaa 370861 aggaaagtcc ttctacagac ctaaagaacg acaacaataa acaggaaaaa aatgcgacaa 370921 ttaaagtgaa agagttgcct gaatatcata cagaggaaaa tgatagcccc atagacgtcc 370981 agaaagaacc cattaaggag gtgcaaagcg atgaaaagga actccagagg gaacatatga 371041 gtgaagaaga acagaaaatg aaaagtacaa ataaaacagc agctccagta agaaaatctc 371101 aaaggttgaa aagaagtaag gaagttaaat ttgaagatga agaaaaggaa gagatagaag 371161 aagataatac gaaagacgaa gaacagaaag aaaagaaaga ggagatccag gagccaaaaa 371221 taacccacaa tgaagaagta gataaggaaa aaaacgaaaa cgaagaaggt gatgatgagc 371281 gtgaaaaatc cacctcttat gaaaatacca atggctctga aagcgaagga gttgacgaag 371341 gagttgacga agaactggga tacgagtctg aacgtgaggc agaaggtaaa ggaaaacaaa 371401 ttgaatcaga agggggcaac ttaaagaaaa aaacggaaaa caaaaaagga gatgatcaac 371461 aggatgatac caaaaaggat tctaaggaca aaaatgaacc attagcaaag agaactaggc 371521 attcatcatc cacaggtaat actagcaatg aaacctcgcc gaaaaggaaa aggcggaagg 371581 caggctctcg taaaaatagc cctcctgcca caagagtttc cagcaggcta cgaaataaaa 371641 aataatcact gctcatatat agatcgcgat aataaacgct catccgttcc atagaggtat 371701 ctgtatttaa tgtagtgtag cagatataga ataaaataac cttaatgaag aaatagaata 371761 tacgtatgct tctccttgtc taatcttttg taattatata tctatttcaa ttaaggctca 371821 gatacttacc ataaacataa ataaaaagca gaaaggcggc tcaattgata gtactttgct 371881 tttagttgac cttcaacaat tcgacgtcga aaaccaaagt actgtttggt ggaatcaaac 371941 ctgggaaacc acgtgggcca taagcatatg ggccagggat ggttaaccta gctttttcac 372001 caacagacaa ctttggaata ccaacatccc aacccttgat gacttggccg acaccgatgt 372061 tacattggaa tggagagccc ctgtcaacgg aggaatcgaa tttttggccg ttctccaagg 372121 taccggtgta atgaatggta accaagtcac ctgtctttgg gaaggtggca ccatcacctg 372181 gggaaattct gtcaattttg acgttacctt caattacttc agacattatt acttgttttg 372241 attgattttt tgcttatact cgagtttagg tgaaaggcct tactttaagc tttcacgagt 372301 ttatccacca aattctttca acgacgtctc tcttccggca attttttttg cccgaaaaag 372361 actaaggcgg gtgaggggaa ttgaacggca ctataatgtg gaggtaaaca gaatgatcaa 372421 gcgctatata cataagtagc tatagattat ttatttcaag acggcaacca acttttcgcc 372481 agaattcctc ccgtgcttaa tatcatcaag taactgtggg atatcatcta acccgttctt 372541 gtaaactttc actgggatgt ggtggatttc accatcattg atttttggat tgatgaactt 372601 aataaatttt atggcggctt ccttgtattc agggtctgct ggcaaagtaa acgtgccaaa 372661 tgggacgtcg ttacctccta tcaaatatag aagggttcct tcaatactga cgttttgcct 372721 cctgtcttcc tccttgatat ctttttcggt taaaacggtc aattgaacga ccgtagcgtc 372781 taagtcatca gcggcacatt tgtacacctg ttgaatagtt tctgtgttgg agacacagtc 372841 caccaagtaa ggaatgttgt tgtacttctt ttttatctgt tcgataacgt cagcatcgtg 372901 gtagtcaaaa agttcatctg caccgtactc tttcaacaat ttttcatgtt tacgagaagc 372961 aacgacgatg atcttgctga aaccgtttag tttttttgcc aattgaataa gcatctggcc 373021 aacagcagtg gcaccacccc aaaataagat gggttgatct ctttgcgctt tggagggctt 373081 ccatgtcatg tccaagccaa aactatgtgt aaggatcata ccagccgtgg tcaatgagac 373141 tgggagggat actgcccctt ctaaagattt tacggggcct tctggtagct tgtctttacc 373201 gcacaatcta aactctctgg ctggtttata agcagtctcg gatgaaatgg cagagtactc 373261 agcaaaggca ccgtttgagg ggaacctcac tgaagcaccg tgaataaccc cataaatgta 373321 atcaccaatg gcaaagcgtg cagcatcaac atttgggccc aactttacga tttggccggc 373381 tgcatcacag cctaagaggg caccttgagg accaatcttg aaatcaatat gtttccaatc 373441 ggtagggtta ccggcaacgg cgacagtctt aattagaaca aatccttctt ctaattcagg 373501 aattggaatg tcctgtttga ctacagcctt gccattttca atgacaacgg ctttcatggt 373561 ttctggaatc gaggcggaca tgcttgatat gcagtatgat attgcttttt gctgtgtata 373621 gttaacgatt ttttttcaac tagaattaca gtactaatca agaagtgaga ggaagaaaac 373681 ggcaaaaaaa aaactctctc cttttaaatc gaagcattgc cgaaatacct taaaaacggt 373741 cttaaatcct taacatctgt ccttactaat cgatgccaat ccaacggagg gagcccatat 373801 gctaggtact aagagtacgc aggggcggaa ccgcgcgaca accgtaagcg gatccgagga 373861 actttagtca gcaggggctg tgatgaccat taaaaaattg cggacacagg tagtggaacg 373921 agcaatcaat gtgatcaatt tgccatttca ttccacgaaa tggtttccat tctaagcatg 373981 aatgctttga cgttacgggt gttggttatt tcggttcttt ttattgcttc cgtgggcacg 374041 tacgagaagg gaagatgaat agaaaaagag tttccgagtt ttgtatgtcc aatgtttaca 374101 taatttatat aacttgaagt ttaatcttgg cataaagctc tagttgtgac gaagtgtgta 374161 ggccatcaca tcagttctcc agttttctac ccaatttttt tatggatacc ttgatttttg 374221 gtttagggct ggatgtcttt acgcccttta tttgtgtttt actgcccaaa ctagtgccgg 374281 tctctaaata tttttctgta ttagtagtag aatcgttctc cattagtaat gctttttttt 374341 tcttttcaaa attgattgcc ttgacgtcta agtagttatt cagttctttt tcctttttta 374401 gcaactcatt cttgctcttc tggtaaaatt ccaggtcctc tttactcaac ctagtaaaac 374461 tttcacggtc tctcaccaaa ccgttatatt gtttttgttt actaatagca ttagacctaa 374521 gctgatctcg cagggacttc ctggttttcc ttttatattc cgcttcatat tttttttgct 374581 ccacttgctc tcgtatcctc tgggcctcta cattaccaac tccttctgac acgaatttca 374641 gtggtttttt ctctcttgca ctattagcat tattatcact ggtagatgac atgatgatat 374701 aacagagccc acagtctttt gttggaaccg ctttctctag gcttcgatgg acttacatct 374761 aattgcacat tctcgtgcgt ttaaacgtca tttttccctc agattggcag tgcatcaaaa 374821 gtaattccta gggacgacaa aaaggcggaa aaggtttcag aaaaataagc ggacttagct 374881 cagttgggag agcgccagac tgaagaaaaa cttcggtcaa gtcatctgga ggtcctgtgt 374941 tcgatccaca gagttcgcaa tttgaaaaat tttttttaat gattacgcat gtggatgtgt 375001 tcagtatcaa ccgatgctcg cttttccaat caaatgatac aagccagacc gaacattgca 375061 tgttttccat tgtaacttcc caggtatatc tgaattagtt gtaaaaagta atagtttacc 375121 cggaatcgtg tgaaaaattt tgaaaaaaaa aaatgaagag ccaagataca atgagatgag 375181 atgaggtgct gaagatgcat ggagattctg tatttatctc aaataaagta cgcaatagag 375241 tatataagcc aagtcacctt ttatatttct tagtttttaa cttgcaaaga cttataagag 375301 acttataaaa caaggagaaa atggccaaaa aagctatcga ttcaagaatc ccgtcactga 375361 tcaggaatgg tgttcaaacc aaacaaaggt ccatatttgt catcgttggg gacagggcac 375421 gtaaccagct cccaaattta cattatttga tgatgagtgc tgaccttaag atgaacaagt 375481 ccgtcttatg ggcttataag aagaagcttc taggattcac ttcgcacaga aaaaaaagag 375541 agaataaaat taagaaagaa attaaaagag gtacaaggga agtgaatgaa atggaccctt 375601 ttgaatcttt tatctctaac caaaatatca gatatgtata ctacaaagag agtgagaaaa 375661 tattgggtaa tacctatggt atgtgtattc ttcaggactt cgaggcatta accccaaatc 375721 ttttagcaag aaccattgaa actgtagaag gtggtggtat tgtggttatt ttattgaaat 375781 caatgtcatc gttaaagcaa ctgtacacca tgactatgga tgttcacgcc cgttatcgta 375841 ctgaggctca tggtgacgtt gttgcaagat ttaacgaaag attcatactt tctttaggtt 375901 caaatccaaa ctgtttagtc gttgatgatg aattaaatgt tctaccgcta tctggtgcca 375961 aaaacgtgaa accactacct cctaaggaag atgacgaatt gcctccaaag caattagagt 376021 tgcaagaatt aaaagaatcc ttagaagatg tccaaccagc tggttcattg gtttctctat 376081 ccaaaactgt caatcaagcc cacgctattc tttctttcat tgatgccatt tcggaaaaaa 376141 ctttgaattt cacagttgca ctaacagctg gaagaggtag aggtaagtct gctgctttag 376201 gtatttctat tgccgcggcc gtttctcacg ggtattctaa tatttttgtt acttctccat 376261 ctcccgaaaa tttaaagact ctatttgagt ttattttcaa aggattcgat gccttaggtt 376321 accaagaaca cattgattat gatatcattc aatctacgaa ccccgacttc aacaaagcca 376381 ttgtgagagt tgatattaaa agagatcaca gacaaacgat tcaatatatt gttcctcaag 376441 accatcaagt tctgggccaa gctgaattag ttgtcattga tgaagctgca gctattcctt 376501 tgccaatcgt caagaacttg ctgggcccat atctagtctt catggcatcc actatcaatg 376561 gttacgaagg tacgggtaga tctttatctc tgaagttaat tcagcaattg cgtaatcaaa 376621 acaacacatc cggtcgggaa agtactcaaa ccgccgttgt ttcgagagat aataaggaaa 376681 aagactctca cttacattct caatcccgtc aattacgtga aatttccttg gacgaaccaa 376741 tcagatatgc tcctggtgac ccaattgaaa aatggttaaa caagctctta tgtttagatg 376801 ttactttaat taaaaaccca agatttgcaa caagaggaac tcctcaccca tcccaatgta 376861 atctatttgt tgtcaataga gatactctat tttcttatca tcctgtctca gaaaatttcc 376921 tggaaaaaat gatggcactg tacgtttcat cccattacaa gaattctcca aacgacttac 376981 aactgatgag tgacgcccca gcgcacaaac tatttgttct tttaccacca attgatccaa 377041 aggatggcgg caggatccct gaccctctat gtgtcattca aattgcattg gaaggtgaaa 377101 tcagtaagga gagtgtcaga aattcattat cgagaggcca aagagctggt ggtgatttaa 377161 tcccatggct gatctctcaa caattccaag acgaggaatt cgctagtttg agtggtgctc 377221 gtatcgtcag aattgccact aatcctgaat acgcatccat gggctatggt tctcgtgcaa 377281 ttgaattact gagagactat ttcgagggta aattcactga catgtctgaa gatgttcgtc 377341 ctaaggatta ttctataaag agggtgagcg ataaggaact ggccaaaact aatttattaa 377401 aggatgacgt taaattaaga gacgcaaaaa cgttgccacc tctactatta aaactttctg 377461 aacagcctcc tcattatcta cattatttgg gtgtttcata tggtttaacg caatcgttgc 377521 ataaattctg gaagaataac agctttgttc ctgtttattt acgtcaaacc gcaaacgatt 377581 taactggtga acatacttgt gttatgttga acgttttgga aggcagagaa tcaaactggc 377641 tcgttgaatt tgccaaagat ttccgtaaaa gatttctgtc gcttctttct tatgattttc 377701 ataagtttac tgccgttcaa gccttaagtg tcattgaaag tagtaagaaa gcacaagatt 377761 tgtctgatga cgaaaagcat gataataaag aattgacgcg gacgcatctg gatgacattt 377821 tttctccatt tgacttgaaa agattggata gctactcaaa taatttgcta gattatcacg 377881 ttatcggtga tatgataccc atgcttgctc ttttgtactt cggcgataaa atgggagatt 377941 cagtaaaact atcaagcgtc cagagtgcta tcctgttggc tatagggtta cagcgtaaaa 378001 acatcgacac tattgccaag gaattgaatt taccttccaa tcaaactatt gctatgtttg 378061 cgaagatcat gagaaaaatg tctcagtact tccgtcagct gttaagccaa tcaattgaag 378121 aaactctacc aaatatcaaa gatgatgcta ttgctgaaat ggatggtgaa gaaatcaaaa 378181 attacaacgc tgcagaagca ctggaccaaa tggaagaaga tttagaagaa gccggttctg 378241 aagccgttca ggcgatgagg gaaaaacaaa aagagctaat caactccttg aacttagata 378301 aatacgccat aaatgataac agtgaggaat gggctgaatc tcaaaaatct ttagaaatag 378361 ctgccaaggc caaaggcgtc gtcagtttaa aaactggtaa aaagagaacg actgaaaagg 378421 ctgaagatat ctatagacaa gagatgaaag ctatgaaaaa accaagaaag tctaaaaagg 378481 ctgcaaatta agcgttctac tctttgtcaa acccttttat agctaaacgt ttacttaatt 378541 tgtacaataa tatagaatag aaacatagtt gatgtttgaa cctttacata ttcctttcaa 378601 tcgtgtcgag cgatataagt attacgatta tgccggcgaa aactgaaccc gttttagaca 378661 atttcaatca acatactcca ctccgtagtg agtaactttt ggagtaatac gaagtaacca 378721 aagaggtcaa aacggaacta tataccccaa aataagcatc attcaaatgg tcgaattaac 378781 tgaaattaaa gacgatgtcg ttcaattaga cgaaccacaa ttttccagaa atcaggccat 378841 cgtggaagaa aaggcttctg caacaaacaa cgacgttgtc gatgatgaag atgactctga 378901 tagtgatttt gaagatgaat ttgatgaaaa tgaaacattg ttggacagaa tcgttgcttt 378961 aaaagacatt gtccccccag gtaagagaca aacaatttct aatttttttg gttttactag 379021 ctcttttgtg agaaatgctt tcacaaaatc cggaaacctt gcttggactt tgaccaccac 379081 tgctttgtta ctcggtgtgc cactatcctt atctatactt gccgaacaac agctaatcga 379141 aatggaaaag acatttgatt tacaaagtga tgctaataac atattggccc aaggtgaaaa 379201 agatgctgca gcaacagcca attaatttta atgatgtaaa agaaaagaga gggttttaga 379261 aaaggagcca tacatgttcc aatgggacac taactaacca atttattttg tttgcacagt 379321 tctatttatt gctttagagt aaagttgaag aaaaaaaatc ttcgttttaa accgctatat 379381 caatacatag tcatagtgta cccattcaga cttctatgaa cttccgatgc gaaacatttt 379441 tttttgcctt tttacctttt ctgttcattt tatctagcat tccttaggtt aatttaaaca 379501 aatgtataaa cttgtacata tttcaaataa aaaactttca gttttatttc aagaaagcta 379561 aatttctttt ggatgtttaa ttgataaagc gtaaatatcc agaaaggtag tgatgtcata 379621 gataatatca ttgatgaaca ttccatggat agcaagtgtc aagccgagtc ccatccaaac 379681 caatgcagaa actatgcttc ctttttggta atctaaaacg taaaccataa atgcgtacaa 379741 taccaattgg atagttggga ttaaaaatgg gaaattgacc attgggaatg gttgcatggt 379801 taaatgagca ataatcatcc gaccaactac aaaggcaacc gaaaaaccaa tcgataaaat 379861 taaagccaaa gaaataaaag atggttgaat caagactaag gtaaaaattg aagagaagta 379921 tgcaaagaat ggcaaaagac catttactgc tttacttata ttttctgcag ttttgcttgg 379981 agttgcagat ttggtcgatt gggattcgta atacctcacg acgtttgtat gagctgtgac 380041 aatattaaat attaatgctc ctgtgcaaaa tgcatacatt agatgaacgg tttcaacatc 380101 aaacacaaaa tcttgccagg agaattgcgc tactttagtg tgccagatgg tttgaggtcc 380161 gtaaattccg actgcaatga aagaaataca caaaacaata ataccttcaa caggaccgca 380221 gaattcagct agataaagtt tgtgggtgtg atactcttcc catgtgctca agtaaaagct 380281 gcacaatatc gcaaattgtg aaaaaatggt catatatgtg taacccatac ctgtcatgga 380341 acagacagga atcattgaca aagttgtgtt gattgaatca atacaatggt caaacaattc 380401 ccctagaggg ccctgctggc ctgtacgacg tgcatgcatt ccatcgcaag catcaaaagt 380461 ctggtataaa aacaaaccta tagcatagga gaaataggtc caacgtggcg attcctggtc 380521 aaaatacggg tcgtagtaaa gtgttgttaa cacattaaat ataataaagc agaaccctaa 380581 taatgttacc aaattgggtg ccatccatag tggaaaaata gtcgcaaact ttctccaaaa 380641 gggcctcaat acatggtttg aaaggaaaga gcggtcatca ctttgatacc taaagtcaga 380701 ttagtaattt aatgttacaa tagttagtat ttatttttct tgccacagaa gatttagggt 380761 gcaataagat aagcaacata cttgtaaagc ttcaagtttc ccaaactact ctgaggaata 380821 aagaatccca ttgtttcccc tgaatcagtt agtaatactg ttttcgaatc catggtagat 380881 gattttcaaa ttcatgaatt cagtatccat taaccttttg ctatctaatc tttcatattg 380941 gcagaacgcc aaagaaaaaa aaaaaaaaac gtcacttccc gcgaattttc acatgcactt 381001 taatcgataa gtttcagtaa tagaactgga ctataggaaa caacaatata ggaaggattg 381061 cacaagatca atttttatgc aataggaaat cttgttattt ggtaaatcag cgagatgttg 381121 tatgacatgc aaatgcttca ctattcgggc aattcgcatt agcacctgag tatatatctg 381181 acataaaaag atttctgaag ttatcgtcag ataagaagat ggagtcaaaa tgtaaacaat 381241 aactttaacc tatataaatt ttcttacatt tgcttttaaa tactcgaaga tttgcattga 381301 acgatcgttg ccgttgactc atttgaaaca gaaaaacaat acacgcagga aaggaacggc 381361 agttggtctg agaaacaaaa ccaacttgca ttttaggctg ttccgatagt ttatcagagt 381421 aagggaaaaa atagcgtgca aaagctatcg aagtgtgagc tagagtagaa cctcaaaata 381481 tgacttcgaa aaaagtgata ttagttgcat tgagtggatg ctcctccagt ggtaagacga 381541 caattgcgaa acttacagca agtttattca cgaaggctac attaattcat gaagatgact 381601 tttacaaaca tgataatgaa gtgccagtag atgctaaata taacattcaa aattgggatt 381661 cgccagaagc tcttgatttt aaacttttcg gtaaagaatt agatgtgatc aaacaaactg 381721 gtaaaatagc caccaaactt atacacaata acaacgtaga tgatcccttt acaaagttcc 381781 acattgatag acaagtttgg gacgagttaa aggctaagta tgactctatt aatgacgaca 381841 aatatgaagt tgtaattgta gatgggttta tgattttcaa taatactgga atatcaaaaa 381901 aatttgattt gaagatatta gtgcgtgctc cctatgaagt actaaaaaaa aggagggctt 381961 ccagaaaagg ataccagact ttggattctt tctgggtgga tccgccgtat tatttcgacg 382021 aatttgtgta tgaatcttat cgtgcaaatc atgcgcagtt atttgttaat ggagacgtag 382081 aaggtttact agacccaagg aagtcaaaga atataaaaga gttcataaat gatgatgaca 382141 ctccaattgc gaaaccttta agctgggtgt gccaagagat tctaaagctt tgtaaggatt 382201 aggaaagcgc cacaaaatcg atgagaagta taaaaaaaaa aaagtaaaaa caataaaaat 382261 aagaatgtgt acctcgatag ataacttaaa taagacaatt tcagaaccac aatattgata 382321 acaccatccc gatttttgaa attatttttt tggtgtaaat gagagaggag gggagtgaat 382381 tagaaatgga aaaaggcttc cttaaatgga aaccagtcaa cttgatgaag aaaatattgt 382441 ctttaccaat gaaaaaaact aaaaacgata taggtttgag attagatata tcatatattt 382501 tagttaatct aatagtctgc tcatacccgg taaacacgta tccaaaactg ctttatagga 382561 atagcttgga tgacttaata ttgtttctaa cagtgtacca tggcaaggga aattttagaa 382621 tttttaattt tagaggtgag aaagaagaca gcgattataa agataatgat cttattggta 382681 tcgctgccaa gtttgagagc aaagattttg aaattcaaga attacgttcg acgctgatta 382741 atgatggaaa gataccaata tcacccattg atctcgaaac aaggaccttg gtcgaagaag 382801 aaaccaataa tgtaatttgt gaaaggatcg gttggctaga tcattttcca ccgccatttg 382861 aactgctgga agagattgta gatggtatag aaaattacct gtccgtttcg aagaatagag 382921 tggctgtttt acattgtcga atggggaaag gccgatctgg tatgataaca gtagcatacc 382981 tcatgaaata cttgcagtgt cctcttggag aagcaagatt gatattcatg caggctagat 383041 tcaagtatgg tatgacgaat ggcgtcacca taccctctca attaagatac ttaaggtacc 383101 atgagttttt tattacccat gaaaaagcag cccaagaagg aatttctaat gaggcggtaa 383161 aattcaaatt taaattcagg cttgctaaaa tgacgttcct ccgcccatca agcttaatca 383221 cttccgagtc tgctattgta actactaaga ttcaacacta caacgatgat agaaatgccc 383281 tcctaacccg aaaagtagta tattcagata tcatggcgca tgaatgcggt ggtaatatga 383341 ccttcatttt tggtagggac tacttaacac tggaaaatga ttgtcgtata gaatttaccc 383401 tggggaccag caagtccaaa gccgccagta gcataatatc ttggacttca tgcgccagct 383461 gttggctgaa tatatacctt gagactttga tgcacataat taaagacgat tcttcgccag 383521 attactttca agtagagagg ttaaagagag acgaaatgct tgggacaacc ataagctggc 383581 aagagctgga cggttttggg gagctcagca ctcacggctt gaaattattt caggcactga 383641 aattggaatg ggaaattata taggtttatg catttcgtca aatccattca ttcgttaaac 383701 ttagttaaaa gtgttatatt tattgtgaat tggtttgttt tggtaggctt ttttctatat 383761 tatgtattct tttccttttc ttcaatattc ttgtatggta ctttaattta ctggcaggta 383821 ttttttggag cggtcaatta tatgaatcaa aacgccattc tagaaacagg aagaaatata 383881 tgagaaccaa ggagtaggtt gaaaggcatt gtagagaaat tttattagta tttatagccg 383941 aagaagaagg ttaagtgaca aattttcatt tataagcctc gctaaaatga atgctagtgg 384001 aagatctcat tccaaaggcc ccattataag gtctgtgtct ttagaagatc ttaagagaaa 384061 ctctagtttc aaaggcaatc taaagtacaa agatgaagtc acttcacata aagaaccaca 384121 ggtcggaaca ttgagcaacg aagaactgct aaaagatttg gacaacatgt tgcgcggtaa 384181 actgaacatg ggaagaaaca gttttcatgc cgataaaaga aataaatcag atggaaatat 384241 cagtgcctta accttcaagg caagatcagg tcttgaggga gatattcgta ccatagatat 384301 acagcaagat agtagtgatg aaaatgataa ttttaagttc agtgatgatg gcgttaataa 384361 ggatagaaat aatgagaaag ataataatac tgataacgcc gttgaatttc aagacgatgc 384421 tgaagaagct gaagaggaga atgaggatga atcatttgct aatgtagatg aactggatgg 384481 ctttgatttg aataaggttt ctgatggcaa gcatgttcct atcaatgaaa agggcgaagt 384541 tgattataat atgccggtag ataaagaatt tcagaaatca cttgaccagt gcgcagcttc 384601 acttgaggaa agatcaagtg caccttatgc tttacaaaga gcagtggact gggaattgaa 384661 gatgttttat tctttggaag atgaactgtc ggaatggttt tgcagctctg attatatgca 384721 ttttggacag acacagactc tgtttaaaca gaaaattacg caaccacaat tattctttga 384781 tgatgaaaac tatgctgcga gcgtagttga atgtttaatt gaagacatcc ccaattcttt 384841 agcatctaat ttactcgcat tatcatatat ttctatggga tgctttgcgt ttacgaatag 384901 caaaagtgag catacaaaga ttatacgacg caacaattta atgcttgttc ctcatattca 384961 agaaattgtt catgccttca agaagattgc aataagttgt agggatgaca acagaaattt 385021 aaagaaacaa acaattttgc tatttcattc gtcaacaatc ctatacttca tatgcagtat 385081 ttgtatagaa ggtagaggag aaaatccgga agcagtaaat gttgttatcg acgcttttga 385141 gaaaacagat ttgttggaat ttttaacaaa gtatattgaa aattggaggt ggaatagcag 385201 attagctatg cgcataagaa atatgatttc tttgctcttc aagcttattg tattacaatt 385261 tggtgacagt tctgtctaca aacagaccaa atcatctatt tataatctcc atggcttaac 385321 atatccatca aagcatccag aaaagctttc tatctcccca ttacattatc aagcattcag 385381 ggaggacatt acttcccgtt ttcctgatta caatatgccc agttctggct tacctaaaga 385441 tgttgacaaa tcagaatctc tttcccagtt tctggaaatt cctcgtccaa aatcaaagaa 385501 tcctctaaat atggcgctca ttgttcctga aaaacatatt gctacacctg ctccttcacc 385561 gccaagctct ccacaattaa tgcatttagg tgaaggtcct agacctcgta aatctttcca 385621 aacaaacatg gcatatccgt gtttgtatcc atctgataat gaaggatctg aagatgacac 385681 tctggaagat aggatagatt taaatataga gagaaaacct gataacgata tagttattcc 385741 attcagtacc gaagaggcag cgagaatatt aagcgagagt ttagaaatta agctgagtac 385801 aaaacaactt tggtacgaaa gggacttatt catgataact gaacgtggtt ggaaacagca 385861 attagaaaat gagccatatg attatgccgc gcttaatcat gatgcaaact cttcaaaaga 385921 ggaaaaaagt gcgatttgca ttatgcagcg aattgacaaa tattataaga gctgcctttc 385981 gagctttaac tctcttgttt ttgtcttact gcaaacaatg gaatcaagct tgacaaataa 386041 ctttcatagg aaaagtgaag tctccgataa aaatcttcta aatatgctga caccccaatt 386101 ggagatcgtg agagctaagg aattgtccct aaagtcagca gcgggcatat tacatgcgtt 386161 attgaagtgg tttaagttaa gccatatttt gaaatttgaa cacttggcgg tagttattca 386221 cgattcgcga tacatcaaca catgcgcatc tattttaagc aaatattctg aggtttatcc 386281 agagagggtt ttcaataaat atgtacaaac cccgaattca ttttggaagg agtgttctct 386341 ctctaacgag tcttatcgtg aatcctattc agtagatgac tcaggagagg tcgacacgga 386401 gattatgcct tcgtttgcat atctgttaag aatcttgaga aaagtcacag ggaataaaac 386461 acaaaggtta aaggagctgc ccctctccat cggcattcta tttaaacgct attatcggct 386521 cttcaacctt gacatgtatc atccaatatt gaaaataaca agagaactca caccattcaa 386581 aaacaagagg tggaaatccg agcatatgga attgatatcg ggggtttacc tttatgaaaa 386641 gctggagtta actgataatt gggtaacagg gaaggatata tcaggagagt tgagcgatgc 386701 ttgtggtcaa gaaattgcac tccgggcctt gcttcaattt tacaattttc aacactatga 386761 aatatctatg gaggaccttg gatatggaca ccgtaatagt tccagccaag atctgttaaa 386821 caaggaatcc gagtatttga atatttaaat ctctacttac ggataccgag gctcggggcg 386881 cgatgttatt gtcattaaca atctcctatc cctccctatg tttatatagt tttcaatgga 386941 ggagcatgaa aaccccttaa atagtgttta tttgatcgcg caatggtgat gattggatct 387001 tcatatcaca agtgggatac taggacaacc gttgttggat ttctattatc ataatatata 387061 cgggtaacga tttttgatgc gtcgcgtttg taaacaaaac taaacaaaac aaacaaatat 387121 actcatttga tggcttcatc tgcatataag aaatagaaga gccagaatac taagcataac 387181 cataatatat attacagtct atttcagttg tagctgaaaa atcaatatgg aactagagcc 387241 cactcttttt ggtataatag aggcattggc tcctcaatta ttgtcgcaga gtcatttgca 387301 gacatttgta tctgatgtag tcaatttact gcgatcatcc accaaatcgg caactcaatt 387361 aggcccttta attgattttt acaaattaca atcactagat tcgcctgaaa caacaattat 387421 gtggcataaa attgagaaat ttctcgatgc tttatttgga atccagaaca ccgatgatat 387481 ggtaaagtac ctctctgtct ttcaatcttt gcttccatca aattacagag caaaaattgt 387541 ccaaaaatca tctgggctca atatggagaa ccttgctaac catgaacatt tacttagccc 387601 agtgcgggct ccaagtatat atacagaagc ttcatttgaa aacatggacc gattttctga 387661 aagaaggtcc atggtatctt cgcctaatcg ttacgttccc tcttcaacct acagttctgt 387721 tactttgaga cagttgtcaa atccttatta tgtgaacact atacccgagg aagatatcct 387781 aaaatacgta tcatatacat tattagctac gacatcggca ctatttccgt ttgatcatga 387841 gcaaatacaa attccgtcta agatacccaa ttttgagagt ggacttttac atttaatatt 387901 tgaagcgggt ttattatatc aaagtttggg ttataaagtg gagaagttta ggatgttgaa 387961 tatatctcca atgaaaaaag cattgattat agaaatttca gaagaattac aaaactacac 388021 agcatttgtg aacaatctgg tctcttcagg gacagtagtg tcattgaaat cgttatatcg 388081 tgaaatatat gaaaatataa taaggcttcg aatatactgt aggtttacag aacaccttga 388141 agaattgagc ggagatacat tcttgattga attaaatatt ttcaaatccc acggagatct 388201 tactataaga aaaatagcaa cgaatttgtt taattcaatg atttctcttt attatgagta 388261 tttaatgaat tggttgacta aaggtctact ccgagctact tatggagaat tcttcattgc 388321 tgaaaacact gatacaaatg gtacagacga tgattttatt taccacattc ctatagagtt 388381 caaccaagaa agagttccgg ccttcatacc gaaagagttg gcatataaaa tattcatgat 388441 cggcaaatcg tatatcttcc tagaaaagta ctgtaaagag gttcaatgga caaacgaatt 388501 ttctaaaaag tatcatgtcc tgtaccagag caattcttat cggggaatat caacgaactt 388561 ttttgaaatt ataaatgatc aatattctga aattgttaat catactaatc aaattctaaa 388621 tcagaagttt cattacagag acgtggtatt tgcgttaaag aatattcttc tcatgggtaa 388681 atctgatttt atggatgctc ttatagaaaa ggccaatgat attctcgcga caccatcgga 388741 ttcattgcca aattataagt taacaagggt tttacaggaa gccgtgcagc tttcttcctt 388801 aagacattta atgaatagtc cccgtaatag ttctgtcatt aatggattgg atgcgagggt 388861 actcgatctt ggacatggat ccgtgggttg ggatgttttt actttagatt acatcctcta 388921 cccccctttg agtttagtat taaacgtaaa tcgtcctttt ggcaggaaag agtatctacg 388981 aattttcaat tttttatgga gatttaaaaa gaacaattat ttctatcaaa aggaaatgtt 389041 gaagagtaat gatataatca gatcattcaa gaaaatcaga ggttacaacc cgctcatccg 389101 tgatattatc aataaacttt ctagaatcag tatacttaga actcaattcc agcaattcaa 389161 ctcgaagatg gaatcttatt atttgaactg cattatagag gaaaatttta aagaaatgac 389221 ccggaaactg caacgcacag agaataaaag ccaaaaccaa ttcgacttaa ttagattaaa 389281 taatggcacc atagaattaa atgggatttt aaccccaaaa gctgaagtac taacaaagtc 389341 ttcaagcagt aaaccccaaa aacacgcaat cgaaaagacg ctgaatattg atgaattaga 389401 aagtgtacat aacacgttct tgacgaatat tctttctcat aagctttttg caactaacac 389461 aagtgaaata agcgttggtg attattctgg gcaaccatac ccaacttcat tggttttact 389521 tttaaattcg gtttacgagt tcgtcaaagt ttattgtaat ttgaacgaca ttggatacga 389581 aatcttcatt aaaatgaatc tcaatgatca cgaagcatct aacggattat tgggaaaatt 389641 taatacgaat ttaaaggaaa ttgttagcca gtataaaaat tttaaagaca gactgtatat 389701 ttttagggca gatttaaaga acgatggcga tgaagagctt ttcttattga gcaaatcgct 389761 ccgttaagaa atgatcccgt cccgtttttc atttataata aatttcctcc acgcaggttt 389821 aatgtataag ttgtaatggt agcaaatgat ttacagattt atttgcaagt aaagagactc 389881 ttttttcgtt ttgtttttcc tggatccgca acacaaagtg tattacatat ggatacatgg 389941 aatatcttta cagtgctaaa tatattaggt taaaaaaagg tcgttttctg taaagaatgc 390001 tttttcagcg ttaactttac gtctttttga taataaagaa atttaattag gtgaagcgga 390061 gatattgaat attatgtact aatgatatga tgagtaggcg acgtaactat cgcgtatata 390121 acatgaatca ggtcgtcgaa aagaactaga ccttcattgg atataccatt cttaggaagt 390181 attttttaat gcccggacct aaaagaaggt catatttagt ctttctttct tttaatttac 390241 cccaatcttc atcggcagaa tcggtatcgt attcgcttgc cttccattct tttaacttct 390301 cgtttgtcat agcttgtctt tccgttaatt tcatcctgat agaatattca cgaaggatag 390361 aaattaaaat tagtgcggca ataaagcagc aaccgcaaaa aatttgtgca tgtaagtaag 390421 gattgctctt atctttctcc accgtcaatg cctgggcaat cacctcacaa accaataaga 390481 aaggcgcacc acagtagttg acgaaggccc aagcgggcaa aaactcttct ggtttaacca 390541 tatcggcaat cagaacggta ttcatgacgt tggcgacacc aacgcatgag ccaactagaa 390601 ttgaaaaaaa gatgagttga acaaacgtat gagcggggat ccagaacgca aacatatata 390661 ttgttaacaa agtggttaat acgatcgtta cgtttgccct accaaactta tctcccgcta 390721 aacccatcag aggtcttccg atggattgcg agccgttcaa aatggcagtc aatgtggaag 390781 cgtcgtgcga tgataatcct ttcgagattg cgtatgaaga taaagtaaaa accatcatat 390841 tgtaggcaaa taatgcgaac atgaaccata atgcaataag taccacaaat ggcttagtta 390901 taacctttaa tgaaaacatt gctttgagct gttcaaacat ggcccgaggc gatttcaatc 390961 ctatggcagg tgtagggttt ctttctttta agagcgcaat agcaactaga acacttatgc 391021 tacacgatat gcctatgata cgaaggcacc accgggtatt tccaaagtca gaaagcattt 391081 tgtttgtagc caaaccgtaa acgacaccac cagcaccggt acccaataat gagacaccca 391141 ttgcgacagc tctttttttc aagaaccatc ctggtaagac ggttgttgct ggaacgaaaa 391201 tcagtgatat tgaacaaccg accataaaac cttgggtgac atacaattgc cataacttgg 391261 tagtaaagga ggccaagaga tatgcggcaa gcattacagc atcaccaaaa agcatggtgg 391321 tccgcagacc aattattctc atcagtgcca tcacaagggg ggataagagt tgaccgagaa 391381 agacagttag gccagcaatt aaggcataat cgtacttcga agcaccaggg taagtatcat 391441 ggtttaagta gtaggcaagg tcgacaccga aggatgcgtt gcagccccac gtggaaaaca 391501 tggtcaagaa cacacagaat gtcacgaccc agccataacc accgtcgggg ggcagttcca 391561 gctgcccggt agacttgttg gtgaatactt tttttacagt cggttcatca ggctcgaatt 391621 cggttattcc ttgggcctca agatccttac cggagtgttt cgtggaagcc ggatatagtc 391681 tattcctcat gagtttggag tccatggaag ctttatgttc tgtagtatca ttttgaatag 391741 aagaagcaga gaaagcagag gaagatggtg ccgacaacga ggcgcctgca gtcgtggtgt 391801 gtgtgactgg gatgtttaac tttgactgga ctgactcatt gtgctgtagc ctaatggcat 391861 cggccacgtc aaatctagat tctaatattt tattaacgtc tgcggaattt tcttccgtct 391921 gcaagttgtc gtcatcgaca gcctttttaa tgtcgttgag ccgattagtt aacgtcctac 391981 taatagacaa ttttctcgat gcatcgttcg acttggtgct gtgtagatca gagcatggaa 392041 ccggagcagc aatagaagcc ttagagaatg atacaggctg tgaagagttt atcgaagaaa 392101 cctcggacga tgtctcagag accattccgg aagaagcaga aaagtagtcg tttgagtgcg 392161 ttgacatttt tcagatttat tttcagaagc cccgtaatta tacctaaaga aaaagtaaag 392221 aaaagtggag aaaacaaaag aaaaagataa aacttttaaa tatgtggtgt gacaaatgca 392281 aaatactatt ctgactcgca catttaacta acaaaagaaa atttgtctaa gtctagcagc 392341 tttggtagaa tatagaagaa acagtctagt tttggctccg atatgagtgg acaaagcatc 392401 aagatctaag gaatgccaag tatttatcca ggttctcccg aagacttttc ttcaatagcg 392461 gcgggggttt tttttttttg cagattgccg agatagcccg cggcaaagat acgttatctc 392521 ggttatcgtc ggcaagcgct attgtaacta gatataggaa actgtggtct gcaaagatgc 392581 ggtataaggc ctccgtctgt tcttactgcg ttatcagcct ttgacagttt tagttcgtca 392641 gggtctttga ccaaatgata aattccctgg tttacatttt cactagtttg ttctcgagca 392701 atgcttagtt ggcacataaa tgagtcaggc actaccactc gggtaacggt ctgcgcgttt 392761 ctttttgcgg ccatgaaatt tttcaggcga tgagcttaaa ggtaaaggaa aaagatggta 392821 ggatgatagg taggatgaag cggtatgaaa gtggaagaag cacaatatag cacgtcgaaa 392881 cagtgctaat catgagcgat gacttgtttt ctaaggcttt ggagaatccc gaccaggact 392941 tgaacgtgga attgcccaag gatgatgttg atttaggtct tttaggtgat ggtgggaacg 393001 agaggaagac cgatgaaccg gtagcagacg cagaaagatc aacaggccta ggatccggct 393061 cttctgaatc cgaatcagat tccggttctg attctgattc tgattctggc tcttcaggta 393121 gtgaggatga ttctgcagat caggacgttg aaggagagga cgaaggtggt gacgcgattg 393181 aaaatgaaga cgaagacgaa gacccttcac cttccggtcc tatactatcg aagaacgaaa 393241 tactagagga aactgttcct gaactaccgg aagattatga aatttcagaa aaaacgatca 393301 tcactcctat tggtgttttg aagtctgcat ttgaaaataa tataatcatt cacgccacga 393361 tgtcgggcga aaagcgtgtt ttaaaagagg gttccatttt ctgtctcgag gatagaactt 393421 tgatcgggat gttgacggag gtgtttggac ccttgcaaaa cccattttat agaattaagt 393481 tgcccgattc aaaaaaaaac ttattcgatg aattaaaagt gcgtttgggt gagaaagcct 393541 ttatagtcac ccctgatgcc cactggatag atactttcga gttaaagcgc aacaaaggta 393601 ctgatgcgtc taatgggtac gatgaagaat tacctgaaga ggaacaagaa ttttccgacg 393661 acgaaaaaga ggcccttttc aagaaaatga agaaacagca acggcaacga aagaaaaggg 393721 acaaccgcaa actagccaac gatagtgaca atgtcaaggt aaagagagct cggcagccca 393781 aggccaacag tttacctaaa ctggtaccgc cgttgggcat gagcagtaat gctccgatgc 393841 aacatgggta caaatcaaga aacgcacgtg aaaatatcaa gcgtgaatcc agtgctacct 393901 ctaatcggaa tggctcctcc ccagtgccaa tcacacagca ccaccaacaa cagttttctg 393961 caaataatta tcccttccct caacaaccaa acggtatgcc ttatccacca tactcacctt 394021 tccctcagcc gactaacttc cagtatccac ctccaccatt tgggcaggcg acaccggccc 394081 aattctccaa cactgttcca tatggtagct tacctcccgc atacaacaat atgtcgccgc 394141 caacacagca gtcgttcatg ccaatgaccc aaagtcaacc gccacttcca tatggcgtac 394201 ctcccatgaa tcaaatgcaa aacccaatgt acatccaacc gccacctcaa gcacctcctc 394261 agggaaatgg taatttccaa caagtaatgg aattacatca aatacttttg cagcaacagc 394321 aacagcaaca ccagtatcag catcagcatc agcaagatcc aagaacctag agtcacgatt 394381 gaaatattta ataataaatg ctatgtatca tagataaact agaaagaggc aagaaaaatt 394441 taacaagttt cttaattgaa tattatttta ctgtcactac cattattaga cgccatctca 394501 gcgtgtgaca tgataatttt tctttttttc tttttttttc ctcaaggcga tgatatgaaa 394561 ctttcaaaaa atttatatgt aaataaaaaa gttctacgag ggtttaaata cggaagttta 394621 tttagaagat atttatactc tgaatacaca cgtagagtac agtaaaggtt ttttagatct 394681 actaatgacc atatcgttga gcaatataaa gaaaagagac cattctaaaa tttccgatgg 394741 aacttctggt gaatcatcgc ttgtaaaaag gaaacagttg gaaagcgcca ccggagatca 394801 agaggaagaa tatacagacc atgaaatcat tatagagccg ttgcactttg ctaataataa 394861 taacactgta ctcacagatt cagaaaatta tctaagatgg caaaatacca tctccaacgt 394921 tgttaaatca gtggtttcca ttcatttttc acaagttgcg ccattcgatt gcgattctgc 394981 tttggtatct gaagctaccg gatttgtcgt ggatgctaaa ttaggtataa ttctgaccaa 395041 taggcacgtc gttggtcctg gtccgttcgt aggctacgta gttttcgata atcatgaaga 395101 atgcgatgtt ataccaattt acagagatcc tgttcatgat tttgggttcc tcaaattcga 395161 tccgaaaaac ataaaatatt ctaagatcaa agcgttaacg ctaaaaccaa gtttggctaa 395221 ggtcggctca gaaattagag ttgtcggtaa tgatgccggt gagaaattaa gtatcctagc 395281 aggttttatt agtagaattg acaggaacgc tccagaatat ggtgagctga catacaatga 395341 cttcaataca gaatatattc aagctgctgc atctgcttct ggcggttcaa gtggttctcc 395401 agtcgtaaat atagatgggt atgctgtggc tttacaggca ggtggctcta cagaggcatc 395461 tactgatttt tttttaccgt tagatagaat tcttagagcg ttaatttgca tccaaaccaa 395521 caaacctatc acacgtggta cgattcaagt tcaatggctg ctgaagcctt atgacgagtg 395581 tagaagatta ggtttaactt cagagagaga aagtgaggct cgtgctaaat ttcccgaaaa 395641 tatcggactg ttggtagcag aaaccgtttt aagagaaggc ccaggctatg ataaaattaa 395701 agaaggtgat actctaattt caataaacgg tgaaaccata tcttctttca tgcaagtgga 395761 taaaattcaa gatgaaaatg ttgggaagga aatccaattg gttattcaaa ggggcggtgt 395821 cgaatgtact gtcacctgca ctgttggtga tttacatgct atcacccctc atcgttatgt 395881 agaggtttgt ggtgcgactt ttcatgaatt atcatatcaa atggcaaggt tttatgcgct 395941 acctgtcagg ggtgtatttt taagtagtgc atcagggtct ttcaactttg attcaaaaga 396001 aagagtgggt tggattgtgg attctataga caataaggaa acccccgact tagatacatt 396061 tattgaaatt atgaaaacta ttccagatcg taagcgcgtt actgtacgat accaccatct 396121 aacagatcag cattctccac ttgttacttc tatttacatt gaccgtcatt ggtgcaatga 396181 attcagagtt tacacaagga acgatacaac tggtatttgg gattacaaaa atgttgctga 396241 tccacttcca gccgatgcgt tgaaacctcg ttcggccaaa attattccta ttcctgttaa 396301 taatgaaaaa gttgcaaaat tgtcatcatc gttatgtaca gtggctacaa tggcagcagt 396361 tccattggat tcactttctg ctgatatttt aaaaacatca ggcttaatca ttgatgctga 396421 aaaaggttat gtcctagtgt ccagaagggt agttccacat gattgtcttg atacttttgt 396481 caccattgca gattcccttg tagttccagc cacagtagaa tttctccatc caactcacaa 396541 cttcgctatt gttaaatatg atccagagtt agtaaaggct ccactaatca ctcccaagct 396601 atctaccacc agaatgaaac gtggtgataa gcttcagttt ataggtttta cccagaatga 396661 tagaattgtt acttcagaga ccactgtcac cgatatttcc tctgtaagta ttccaagtaa 396721 tttaattccg aggtaccgtg ccactaattt agaagctata tctatcgact gcaacgttag 396781 caccagatgt aattccggta ttttgacaga taatgatggt acagtaagag gtttatggct 396841 tccattttta ggcgaaagat tagaaaataa agaaaaggtt tatttgatgg gattagatat 396901 aatggactgt agggaagtta tagatatctt aaaaaatggc ggtaaaccaa gagtaagtat 396961 agttgatgct gggttcggtt caatttccgt tctgcaagcc agaattagag gtgtgcccga 397021 agaatggatc atgcgtatgg aacatgaatc aaataacagg ctacagttta tcactgtttc 397081 tagagtttct tatacagaag acaagattca tttagagacc ggtgacgtca ttttatctgt 397141 gaacggaaaa ttagtcactg aaatgaatga tttgaatgga gttgtaagct cagctgatgg 397201 tattttgcca tcagccatgt tagattttaa agttgttcgt gatggtaata ttgttgattt 397261 gaaaattaaa accgtggaag ttcaggaaac cgaccgtttt gtaatatttg caggtagtat 397321 cttacaaaag ccgcatcatg ctgttttgca agctatggtt gatgttccaa agggtgtcta 397381 ctgtacattc aggggagaat cgtcaccggc gctccagtac ggtatatctg ccacaaactt 397441 cataactcat gtcaatgaaa ttgaaacacc tgatctagat acatttttga aagttgtcaa 397501 aacaatccct gataatagtt attgtaaaat gaggttaatg actttcgaca atgtgccctt 397561 cgctatttca ctgaaaacga attatcatta cttccctact gcagaattga agagggacaa 397621 catcacgcac aaatggattg aaaaggaatt taccggcaac agccaaagtg aaaaataggc 397681 cagatttgat aaaacattta tatatgtatg tatgtatgta tacatcaaag tcttccataa 397741 agaacagttt ttttatagac tatcacagga gcgttaagat ttacaagttt ttcaatcatt 397801 ttgaggggtt aggattatga tgtcgagatg gttgcaagcg cctgacgaaa tagtatttaa 397861 ttacttcaac gcttgaattc tctaaggtat tatcgattgt ataaatttat ggttattgtt 397921 tcatacttat ttatatacat gaagaccgaa agcaaatact caaacaattg atttggggtt 397981 aacggtgcgt ttggtttaga ggagaacata attattccac cttcaatgat agggtaataa 398041 ccgctttaga tgctttgaat aagctggatg ggcaattttc cttccggtta aggcttttaa 398101 tgatctatgg gaccagccta tattgccatg ttttcttcca gctatgcctc ttttaaaagt 398161 attaccggta cgcctccacc tctttgctgt acctttatga gttttcatta aagttcttat 398221 tgttattgta gaaacgttat tgaatagaaa gccgttgagc ttcactttga aactatttga 398281 acctttaagt agtggtttga gtacattgaa aacagacatg ttttggtttt ggtctcctcg 398341 ttgccgtttg ttatgcaagc taattttcat gatagatata tatactatct tttttgtatt 398401 tgaccagatt tttttaggct ccgcaaattg gcgagggctt caaggttgaa aaaattggtt 398461 gtggtttata cgcactgcta attatttaca gaatgaaaga gaaaaagaaa aagatatata 398521 tatatatatt agaacatgca tacgtgtata ttgaaacaaa aatgaaaaca aaaattttca 398581 aagtgagatg tcaatgtcat tgctgctctt cctttgtcat ttagtctact ttgttactta 398641 gtttttgtct tctcctaaaa gtttttaagt ttatgtttac tgtttacatt aaaccctgtt 398701 cgcgtaattt agctaaagtt tcttgaatct ttttagccaa tactggatca gacctaattc 398761 tttgttgaac tttagcggct tcagcaaaag taatggcttg taatttctct tccatagttc 398821 tagccaaatc agcggattct tcgaataatg taatagcttc atcgatatct tcctgctgca 398881 atttcatttg agctaaaccg attttagctt gctcacttct tgggtctagt ttggacgctt 398941 tttctaataa attcgtggct tcaataaaat tttctactgt tggatttctt gtcaacaaag 399001 tggctttacc gaccaaaggc gcaattccaa cataaatacc atccaacttg ttttctaatt 399061 caatagccaa atcgtactgc ttcaaagcct tgtcaaaatc gttcttgtct gttaaaattt 399121 cagcaaagaa atttggaact tctggtgcct ctggaaattt tctcttagct tcactaaaca 399181 aagtttcaca gtcatcaaac ttgttttcac ggtacgctag acatgctaat tgaatataag 399241 ggaagatatt ctctgggtct aattccttag ctttatcaaa atcttttcct gcttgatcat 399301 agttttgtaa aatgaaattc atttggccgc ggtgatagta aacagaagaa ttgtttgagt 399361 ccagtttcag cgctttatcg aagtagttat aatattcagt cgagtcattt ctatcagcca 399421 tgattaatgc catgtagata tatgaattga ctcttgggaa caattcaata gctttcttga 399481 tgtcttcgtg agctcccaat ggatcgtttt tcaagaactt gaaaatacct gtgtgttcta 399541 atgagatggc caatttttcc tttaactttt catcctcatt gttcttgtcc aattgttctt 399601 caaataacct tgcagctttc gtgaaagact catcagcctt gtcgtaactt tcgggagatc 399661 ttttgtacaa attacttaaa ccgttcatta actctttatc agcttcattg gattcatcat 399721 aattggcaaa agtcaactcg ggtttgaaaa taccaaagaa agaggccatg gatgtaactg 399781 aaggcaagtt ttcctgcttg tctttgcgtt ctttagctgg ttgggtggat aattcagttg 399841 gagtagcagt agcggtgtca atatcgccaa acttttcttt caatttagac atagcttgct 399901 tattcaagtt cctctccaac attggttcaa tagaggcgtc attgaagtca ccatttagag 399961 acaatacaga caaatcgaac atcgcatccg caaattttcc tagcccttcg ttagcagaag 400021 ctcttctcag taaaactttt gagtagtctg gttttaattc aagagcctta gtactcattt 400081 caacaacttt tttcaagtca cccacagaaa catagcaagc cgataaattc gagtagaaaa 400141 ctgggtcttc tttcaattct aatgcccaat tatagtactt aatagcatcg tcatattttt 400201 tatttctaaa gaactggtta cctttgtcct ttaacgctaa tgcatattta tccttttctt 400261 cagcggtgaa atttgcctta ttggaaaaat ctggttcgcc attactagaa accgggtaga 400321 taggaggatt tgatggggct gtagatttct tagcaccttc agtctccttt tgagagtcct 400381 ttgtgtcctt tttttcatct ttgttgatcg tgttcttttt tcctcgttgt tgttgttgtt 400441 gcaattggtt gtaataatag taggcaccga tggcagtacc tgtagcagca acggttgcca 400501 aaatggctgt cttgttcctt gtaatgaagc tcttcattgg caattgagaa cctagatgtg 400561 agctgtaatt tcacttccga atcttgcttc tcttttatgg tgagtggtgg agttcctctt 400621 aattccttta agatcttttc cactggtcgt ccaaacacaa aaggtggttt aacgccatct 400681 tattcatcgt atacagtgat attgtatatt ttaaactaat ggcaatgaaa ctctttcttt 400741 ccttccactt aatccttgaa tgtttgtttc tgaaatgata taacactgtt gaaccttatg 400801 gaaacatttg aagttgcctg cacagtgttt ctttcaataa agtcatcttt attatttttg 400861 aatagttgac ttaattacat catcattatc tacgtattat ggagtttttt tcagttacgc 400921 agtgaaaaac tgttatagta ccgatgagat gagtgagacg agcataaaat taacttcggt 400981 ttctgtattt gctattgtcc atccctatcc tagttttaaa aatataattc tatcaagtta 401041 tggagtgcca gaggtgccct gcatctgcca gaaatccagc gacagttgag tctagaaagg 401101 aaaagttttg cgatgaatgt ttcatcaagt ttgttagtac taaacaaagg aaacaaatga 401161 tgaaggatga atatttcagg aacctattta aagttatata cccatttgaa aaagaaggat 401221 ccgtctctaa gattctgctc cccttatcac attctgattc aggatctctg gttatgttag 401281 atattgtgca cgacttgcta ttggaacaaa ctaagcaaca caataatcgt acaggcttta 401341 ccgtcgatgt actcacggta ttcaccgagg aaaatgtttc tgttatcaaa gaacgtatgg 401401 aatccttgat taatgaaaaa atgtcacaac tgaataaaat atccaacata tttaatgtcc 401461 attttattga tgttaacgaa tttttcaaca atgcatcgga agtatcgact tttatcattg 401521 acaatgaaaa ttttgagatt ttcagcaagt caaagtcagt agatgatagc aatatattaa 401581 cattaaaaga aatattaggc aaatactgtc tcaataattc atccaggtct gatttaatat 401641 cgattataaa aactcaattg atcaagcatt ttgcatacga aaatggttat aatgccataa 401701 tgtggggaca ttccatgaca aagctatctg aagtaattat ttctcttgtg gtaaaaggta 401761 aaggttctca aatagcgacg tttctagact cggaatcatt tgatactttg aataataaac 401821 catgtaagta taaaaaccta tatcctatga aagatctatt atccgtcgag attgaaagtt 401881 ttttacaaat cagaaatctg gcacagttcc tcattaacgt tgaagaaact aatgtgaagc 401941 ctaattgctt gatcgccaga aaatcactgc cgtcacttgg tcaacaaaaa ttggtaaaaa 402001 atatgacaat caacgaaatt accaacaaat actttcagga tattcagaac gattattcaa 402061 atataatatc gacagtttta agaaccgcag ataaattgac gcaacctaaa tcaagtatgg 402121 ctaagccgtc acaatgtcaa atatgtcaat ctaaaatata cacaaatcca tccaattggt 402181 taaataggat cacagttact tcgccttatc ctgtggagac cactgaagaa aagtatttat 402241 ttaaacagtg gcaagattca aaattagggc aatctcacac acattatgtt gaattgttga 402301 atgaaatcaa acagggtgcc agtaatagcc tcgatgttga agacggtgat gtcaaattgt 402361 gttatggttg tttaatctta ttgaatacca gtatcaagga taagaatttg gtttggccaa 402421 aagtcgatac catggatatt acggcaaatg cgaccaataa aaacaaagaa ttgagccaaa 402481 tattggatca gttcgagatt aattccgatg gggaggaata atgaaatgtc aaaggcttcg 402541 ctattccaat ggttatgtat ttatttattt atttagcaat gtattttact ttacatcgct 402601 tcggctgcct tcatttacag tgtgtctata aaacgtataa cacttattct ttcacttcct 402661 atgcaaaatg cttaataatt cattagaccc tgaagttcca ttcgaacgga cgtcgaagtt 402721 gggctcattt attgcactag acctgttttg cagcatattt agtagtttat ttgaggaatt 402781 ttcgttgtta tcagatgcca aggaatatcc gtcagttgca tatacattat tattgaaggc 402841 gctgctgttt ttattaccat gcaatatatt cagtaattca tgagaactgt ccttatttga 402901 aatattctca tacccatcat taagaggctt gggctttaag tagtttaata actctgttga 402961 attcttatct aattcttgat tatttgtagc gtcgttgcgt ttcattgacg ttgacatttc 403021 acttgacggt ccaccctcag tgcgagggta cccggtagag tcgttctttt tcaaaatatt 403081 caacaatcct ttagctgaat ttttctgcga gtatgagtca acattatagg gctgttttgg 403141 tgctgtaatg tctttttcct tttgttttaa cattcccaaa agttcgcttg cattcgcatc 403201 gtttatactt gaagttgatg cattttcttc gctattttga ggttttgaca cagaattcct 403261 cttcaacatc atcatgattt cttcatcccc acttagatgt tgagattttg gtgattgctg 403321 atttgaagat acagtagagg aaattgggtt tcttagcatc tgtaataaat cttttgatga 403381 agacacattg gagcttgaat caaaagcttt tttatcattc gccagactgg caaaggtttc 403441 acctcgtttt agtattttaa ctttgggtac cttttttaca gtatttgttg ttgatgataa 403501 cccgacagtt tcgtttatag atttattact ttcagtgggc atatctctat gaggcacttc 403561 accgtcttgg aaattgttct cttttaaaat atcttggcta attaatttgg agttgtcttg 403621 agtttgttcc agttcttcca atttttttcc atcttcttcg tcagaactgc tttcgaagac 403681 ttcatatgca tcactatcac caatgtgaat ttcttgacga tatttattct gcattcctac 403741 tgatgaattc tgtttactct gagtcgaggg tgaagattta ccaggccccc attctacact 403801 attagattct gcagaagcgt tcaagtttgt tttgcttgcg tcgttccttg gtttttcctt 403861 ttgacttctt cggctgtctt tttcgcttgg cataacgttc accccaatat ctacattcaa 403921 tgaatttctt tcatctctag ctgtctccac ctcttcatct gaactactct cgaaatcttc 403981 atattctgca tcttgtatac cagatacgga gtcatttggt aaaaaggaag tatctggttt 404041 ggaagcgtgt atcttctgcg atgatgttgg ttttttcaac aaatctagca aagcttgaga 404101 gtttgaatga gcagtttcat cattattgtt ttgcttgatt gaattcaagt ccgttcctct 404161 ctgtaagatt ttaagctttg gctttttgct tgattgcacg ttgctgtcag gctttttcga 404221 atttagtata tctaacaact gcccagggga ggagctgctg taaccagagt ccctcggtaa 404281 aggagcagga ggcaaggaaa acggttgaga tactgctggt ccagaaaggt tatgcatgtt 404341 tggaacacca aaagccatcg gattcggagg agcattaaaa ttagggggga ccggagttgg 404401 aatagggtta gcgctattac tattgttagt taatggtaac ataaatggga aaggtgcaaa 404461 aggctggcca ttcattgtcg caaacaattg aggatttgac atgaatacgt tagccattgg 404521 catagtaggt ggtataacat tcttattgtt agcaaacggt tcagaaagag atggaaatat 404581 tgaaggttgt tgttgagaag aaaacgatga ctgctgatcc ttctgttggt tgtgttctcc 404641 tgattgctct ttcaaatgct gaagctcttg gctcgagggt acctgtccgt tggagaccgc 404701 attattatta ctgttagctt gcactgcagt atgtaacata ttcagcaact ctctaccggg 404761 atcaatctgc tcctccttag tgatacccaa caacaatttc aattgttctt ccgcatagga 404821 tttcaattga tcttcatttt ttatttgcct ctgatgcctt aaccacattg ataagggtct 404881 catcatggaa ttaatcagat aatacttgat atttgatttg tacattgttt tagaaatttt 404941 cttaaaatcg aaccattcta tcttatcaat ttcatttcta acttgaggtt taaaattgaa 405001 gacttctgaa acaccagata tcaaaaatat tttgtaattt ttaccttgaa tatttctttc 405061 aatgaattgg ttgtcgtcaa tatagtccgt caaatcgaaa ccaatttctt ctttcacttc 405121 tctaatgcaa caatctatgt cattttcatc tttagatatc ttcccccttg ggaatgacca 405181 agaatccgat tcagtaccct gtaccaataa aattttactc aggttctcgt taaatatggc 405241 agcgcccctc accggtatac ttttcttata cttggagaat tgctggagtg cctcatccac 405301 tcttatgtcc catttccaaa ccagaggaca tagttttatg atcaattgag caaatgattt 405361 aatctttagg gagggtaaag ttggattcat caatttgatg aaatccgtgt aaaaccatga 405421 ggcttcttca aaatgaaata actctctctc gacactcgat aaatcttcat tcggacaatt 405481 tataataaaa cgtactaata agtcctctaa aattctatca acagaagtaa cgttctccaa 405541 tgcgtgtcgt agcggcagtg acattgtcta atgcgaaggt acttttattt ttttcagatt 405601 caaagcaata ttatttagac aattgatact aagtgagctt aaggaggatt aaacaactgt 405661 ggaatccttc acaaggattc aatatttgtt tttcctggtt attttgccat cattcaactt 405721 tcctcagacg taaaattcgt gcttagtgat gtctcaatat tcccgcaggg taataaaatt 405781 caataactat cactatatac gcaacagtat taccctacat tgctatcggc tcaatggaaa 405841 tccccatatc atagcttcca ttgggccgat gaagttagtc gacggataga agcggttgtc 405901 ccctttcccg gcgagccggc agtcgggccg aggttcggat aaattttgta ttgtgttttg 405961 attctgtcat gagtattact tatgttctct ttaggtaacc ccaggttaat caatcacagt 406021 ttcataccgg ctagtattca aattatgact tttcttctgc agtgtcagcc ttacgacgat 406081 tatctatgag ctttgaatat agtttgccgt gattcgtatc tttaattgga taataaaatg 406141 cgaaggatcg atgaccctta ttattatttt tctacactgg ctaccgattt aactcatctt 406201 cttgaaagta tataagtaac agtaaaatat accgtacttc tgctaatgtt atttgtccct 406261 tatttttctt ttcttgtctt atgctatagt acctaagaat aacgactatt gttttgaact 406321 aaacaaagta gtaaaagcac ataaaagaat taagaaaatg gttaaggtca gtttggataa 406381 cgtcaaatta ctggtggatg ttgataagga gcctttcttt aaaccatcta gtactacagt 406441 gggagatatt cttaccaagg atgctctaga gttcattgtt cttttacaca gaactttcaa 406501 caacaagaga aaacaattat tggaaaacag acaagttgtt cagaagaaat tagactcggg 406561 ctcctatcat ctggatttcc tgcctgaaac tgcaaatatt agaaatgatc ccacttggca 406621 aggtccaatt ttggcaccgg ggttaattaa taggtcaacg gaaatcacag ggcctccatt 406681 gagaaatatg ctgatcaacg ctttgaatgc tcctgtgaac acctatatga ctgattttga 406741 agattcagct tcacctactt ggaacaacat ggtttacggt caagttaatc tctacgacgc 406801 gatcagaaat caaatcgatt ttgacacacc aagaaaatcg tacaaattga atggaaatgt 406861 ggccaacttg cccactatta tcgtgagacc ccgtggttgg cacatggtgg aaaagcacct 406921 ttatgtagat gatgaaccaa tcagcgcttc catctttgat tttggtttat atttctacca 406981 taatgccaaa gaattaatca aattgggcaa aggtccttac ttctatttgc caaagatgga 407041 gcaccacttg gaagctaaac tatggaacga cgtcttctgt gtagctcaag attacattgg 407101 gatcccaagg ggtacaatca gagctactgt gttgattgaa actttgcctg ctgctttcca 407161 aatggaagag atcatctatc aattaagaca acattctagt gggttgaatt gcggacgttg 407221 ggactatatt ttctctacaa tcaagagatt aagaaatgat cctaatcaca ttttgcccaa 407281 tagaaatcaa gtgactatga cttccccatt catggatgca tacgtgaaaa gattaatcaa 407341 tacctgtcat cggaggggtg ttcatgccat gggtggtatg gctgcgcaaa tccctatcaa 407401 agacgacccg gcagccaatg aaaaggccat gactaaagtc cgtaatgata agattagaga 407461 gctgacaaat ggacatgatg ggtcatgggt tgcacaccca gcactggccc ctatttgtaa 407521 tgaagttttc attaatatgg gaacaccaaa ccaaatctat ttcattcctg aaaacgttgt 407581 aacggctgct aatctgctgg aaaccaaaat tccaaatggt gagattacta ccgagggaat 407641 tgtacaaaac ttggatatcg ggttgcagta catggaagct tggctcagag gctctggatg 407701 tgtgcccatc aacaacttga tggaagacgc cgccactgct gaagtgtctc gttgtcaatt 407761 gtatcaatgg gtgaaacacg gtgttactct aaaggacacg ggagaaaagg tcaccccaga 407821 attaaccgaa aagattctaa aagaacaagt ggaaagactg tctaaggcaa gtccattggg 407881 tgacaagaac aaattcgcgc tggccgctaa gtatttcttg ccagaaatca gaggcgagaa 407941 attcagtgaa tttttgacta cattgttgta cgacgaaatt gtgtccacta aggcgacgcc 408001 cactgatttg agcaaattgt gatctccctt gccccagtgt acacatatat aaaaatatat 408061 tcatgcctat atgattatgt atcggaatcc aaaaacttat ctttatattg cttcgtttcg 408121 tagttagcaa tgaatcatct tatcatgatt cctttttttg ttttggccag attaatgtat 408181 cacggtcgac ggcgaaggca tcaaccattg ttgtggaatt tcaaacacaa tacttgatga 408241 ctccaaacgt gggcatatat tttgatttga aaagaagtcg agaaagtata gcaacgcatt 408301 gtatacgttt gaagctttca gcaaaggata taccgtggaa atgtacacgc ctatccctgc 408361 taatacccct gctcccactg caccaacttc atcgatgacg tccaactctt catccgcatc 408421 aaatgccaac accactagca gtagtggcat aaacccaagg aacagagcca gtggtactcc 408481 atccaatgag cgggctcgtc cggcgtcggg tatcagttcg tttttgaata ccttcggaat 408541 taggcaaaat agccagacag cttcttcttc tgcggctcct gatcagcgtc tattcggcac 408601 aaccccatct aactcacata tgagtgtggc catggaaagt atcgataccg ctccgcaaca 408661 gcaggaacca cgtctgcatc atcctataca aatgcctctg tcggcccagt tccacgttca 408721 tcgcaactat caactcccca tctccatatc tctcactgcc cctacaacca cagaccacca 408781 gcaatcatct gcgcataatt tcgaaggcaa caatgttggt aacgttcaag agtctttgaa 408841 tcagcggcag cctaacggta ctaacaatac cacaacctcg ataatttcca tggcgccagc 408901 ggctacaacg agaaatatag tcggtggtgc agatggatct actattgtta acaacagtca 408961 ggaaatgtat aagaatttac gtcacttgat atatgctgca aaccagccaa atgggaccga 409021 aattttacat ttggatttac ctgcaacaag tgcagaggag tcaaacaata tgttcaatgt 409081 agatgaggtc actttgaagc aaaggaaaga taagcatggt ctttttagta taagactaac 409141 cccatttatt gatagttcgt ccacgacaaa tcaaggttta ttctttgaac cgattataag 409201 aaaggctggc cctggatccc aattggttat tggccgctat actgagcgtg ttcgcgatgc 409261 aatttctaaa atacctgaac aatatcatcc agttgtattt aaatccaaag ttgtttcaag 409321 gacacatggt tgttttaaag ttgactctca aggtaactgg tatataaagg atgtgaaatc 409381 atctagtgga actttcttaa atcaccaaag gctctcaccc gcttcctctt tatcgaaaga 409441 tacccctctt cgtgatggtg atattttaca gttaggaatg gattttagag gtggcacgga 409501 agaaatctat cgttgtgtaa ggatgaggat tgagctaaat agatcatgga aactaaaggc 409561 aaattcgttc aacaaagaag ctttacagcg tttgcagaat ttacaaaaat taactacagg 409621 tattgaagaa gaagattgtt cgatttgcct atgtaagatc aaaccgtgtc aagcaatttt 409681 catatcacca tgcgcacata gctggcattt ccgttgtgta agaagattgg tcatgctctc 409741 atatccgcaa tttgtttgcc ccaactgtag atcaagttgt gatttggagg cctcctttga 409801 aagtagtgac gaggaagatg aaagtgatgt ggaaagtgaa ggtgatcaac tggtggatca 409861 acttagcgtc ttaatggaaa cttcaaagga tgttgatagc catccttaag gtcaaagaaa 409921 atacacagtt tgaaaaataa agaaaaacca ccgaactcca catctcgtac cttaatatta 409981 ttttaattat tctcttagta tttatatatt tgcgccgttt acatatttga cttattgttt 410041 tcaggaatac aatacctcca tcgttggcag tcaattttgc tttcacatat aaaactaaaa 410101 aaaaagtaaa gaactcggtt aatcctcggt tagtttgcca agctcaccta ttaatcttaa 410161 taggacttct tgagtttgtt gtttgcccag accatactta tatatttcat gcccaccttc 410221 aactattttc cattcttgag tcttgtgaga aattttggtc aaatctcttt gccaatcgcc 410281 ccataatgcc gacttcttca ccatttcctt agagctaacg atgcttgtct tcacattttg 410341 caaagattct gcattgtttg tcacatctct gtaacttaga attgaactcg tcacgctttc 410401 caaaaacttg gaacgcaaga aacgtccttg atatttcata tcacgcccat atatacgttc 410461 tttagaccca tgatgagcta gtaaccatga agtctgtaat ctccatccta aactcgacca 410521 aatgcctttc caccataatc taaattcgtt atgcctttct atctccgaag gtaaccaagt 410581 cttatcatgg ttgcggccat ccccatcatt accattgcca tcgtcgccat cgtcgccatc 410641 accacggcct ggaggtagta atctttgaat gtagtttttt aacaatagtt cttcatgcca 410701 tgattcaaca agcatcatgc tatccacaat atcgacattc ttggcggtaa atactcttgt 410761 aaatagcccg ccaaggtcgt atcctactgt agtgaaggga cctttaattt ttgcatcttt 410821 gatcaatgcg taccttaaag attccgcaac catcgcaata gagattgggg cgggaggaga 410881 atcgctcaac ccgtaccctg gtctatcgta tagacaatat ctttgaattt tgtctaaatg 410941 atatagttcc tcaatccagg tggcagaaag gtaaccagta tcataacctc cgtgttcaaa 411001 caagatgata ggttgcttct tattttcaga caaatctgtg ttgttttctt gatcaaatac 411061 gtcaccataa caagttatat gcaactgata ggttttagcg gcatctacgt aatggaacgc 411121 ctcgtacgag ggcgactgaa cggttattgg taatttgtga gtcaatctgt aggtatccaa 411181 tgtcgttaaa agtgtattca gggtgaataa agcgaagaat attaaaatta aaaacttaat 411241 agtattcctg aacccaatgg atacccattc tgtcaatgta tgtttgtttt ggaccagctg 411301 cgagcggtgg gtgggggttg gcgacccaga gccatattgg cttctgtccc tgttttcggt 411361 actatttgta tggttttcgt tgaaagtact aatattagca tcatcaattc tgcgttcctc 411421 caatggctca tttattgagt tgttgtaaaa caagagatac caatctaata ttgccccaat 411481 aaaaaatgaa aacgaagtcc acaaatatgt aaacgtgccc acaaagccga ttctttgcct 411541 agtgtattta attagatagg tcaatgctag attgaacaac gtcaaaacac agagagttac 411601 atttaagctg taatctaaag ctgagtacag tcccagctta ttaaaccaga gattgaaaga 411661 attagctatg atcgagatga atattaaagt caagtcgtta aaacttgcgt acctgttact 411721 gaatccgaaa agaatattga tattgaaaaa gaaatctgaa atcaaagtgg tgactagcca 411781 gatggtgtta attagaatta ggatatttaa tatccatttg gagttatgaa taaagattct 411841 ataacctttg cgaatttgaa agagactatc tttgatgaac ccatcggatt caatgtcacg 411901 accttcatta actgctgggc cattcgcgga tcctgcacca agggtccggt ggttgttgtt 411961 cagcaacggt tgcgcttctg ggtgttcact atctatatct gttctttcca ttcccgtcct 412021 tgccggatca ttatctaaac cattagcctt catgatctgt tcgctctgat gcctacagtt 412081 ctttcttcaa tggctttcct ttcctttcct ccttatagaa tatagcaagg catctaactt 412141 ttagtttttc tctcatccct ttaaactgca cgatggttaa aattaggggt ccgaatagcc 412201 ttgcaaggaa tagattaaag aacactatat atgcatagcc acttcaaaac gtgctgagaa 412261 catgccatca aggttgacca atacgattgc tgattcgaca acttctacat tacataggca 412321 tatacatatc agaaaaacgt gctttatagg tacatttttt aattccttaa acataacttg 412381 cttctatttt gggatagttc cttttctttg aactacgttt tttgggcaga aatataaaaa 412441 aaaaccgaaa aaaacggcac gcaagaaagc ttattcaaaa agacgcaaca atatcataga 412501 ttattctaag taccaacaac gtgataaact ttgttctaat aaagctacat cttatctctt 412561 ctgtacagct ttattggggt gaatcatatt tacttcaatc cgggtaatgg taaacgtaac 412621 aagtgataga aatattcacc tgcgatgagc tggaaaaaaa aaaaatttca aaagaaaacc 412681 atactaatgc tgaggtataa agtaacgaat tggggaaagg ccatcaatcc aaagtcggaa 412741 aaattgaact tcacataaag taccaggcaa atgactgaag acatcgaaca aaaaaagacc 412801 gctacagagg taacaccaca agaaccaaag cacatccaag aagaagaaga acaggatgtt 412861 gatatgactg gcgatgaaga acaggaagag gaaccagaca gggaaaaaat taagcttctc 412921 acacaggcaa catctgaaga tggaactagt gcctcttttc aaattgtaga ggaggatcac 412981 acgcttggaa atgcccttcg ttacgttata atgaaaaatc cagacgtaga attttgtggt 413041 tactcgatac ctcatccttc tgaaaaccta ttaaatatca gaattcaaac ctacggtgaa 413101 acgaccgcgg tggatgctct tcaaaaaggg ctaaaggact tgatggattt atgtgacgtt 413161 gtagaatcta agtttactga aaaaatcaag agcatgtaga tgttacggat cgactcaaag 413221 accctctgtc actctgaaat ttctaataat tatgcacacc acgctagtat agatacagct 413281 tgatttgtgt atcccgttta tagtcgtgct atttaaaatc tatgtataat ataaccagat 413341 aaaaatacac cttcgtacaa ggtgctaata atgttgagaa ttcgaaattc ctttttaaag 413401 gcgtattccg tattgaatga ttgaaaaatt tatttctttt tttatttctt tttttttttt 413461 tttttttttt ttttacgccg atgctcatcg cagaaaattt ttccttcagt ttatttgtct 413521 tataaaaaga ctgtcctacg ctcaaataac ttatactttt ctgtatctca ttcaaattat 413581 tttcttgtca acaacctgta acagaattaa gcactattaa ggcaaattta gagcaaatat 413641 gacttacggt ggtagagatc agcaatataa caagactaac tacaagtcta gaggtggcga 413701 cttccgcggt ggaagaaact ctgatagaaa ctcttacaat gacagaccac aaggcggtaa 413761 ctaccgtggt ggtttcggtg gtcgttccaa ttacaaccaa ccccaggaat tgatcaaacc 413821 aaactgggat gaagaattac ccaaattgcc aactttcgaa aagaatttct atgttgaaca 413881 cgaaagtgtt cgcgacagat cggacagtga gattgctcag ttcagaaagg aaaatgaaat 413941 gactatttcc ggacacgata ttccaaagcc aatcaccact ttcgatgaag ctggtttccc 414001 agactacgtt ttgaatgaag tgaaggctga aggatttgac aaaccaactg gcattcaatg 414061 tcagggttgg ccaatggctt tatctggtag ggacatggtt ggtattgctg ccactggttc 414121 cggtaagact ttgtcttatt gtttaccagg tattgttcat atcaacgctc aaccattatt 414181 ggctccaggc gatggaccaa ttgttttggt tttggctcca actagagaat tggctgttca 414241 aattcaaaca gaatgttcca agtttggtca tagttccaga atcagaaata cctgtgtcta 414301 cggtggtgtt ccaaaaagtc aacaaatcag agatttatct cgtggctctg aaattgttat 414361 tgctactcca ggtcgactaa ttgatatgct agagattggt aagactaatt tgaagagagt 414421 cacttacctg gttcttgatg aagctgatag aatgttagat atgggttttg aacctcaaat 414481 cagaaagatt gttgatcaaa tcagacctga tagacaaacc ttgatgtggt ctgccacttg 414541 gccaaaggag gtgaagcaac tagccgctga ttacttgaat gatccaattc aagttcaagt 414601 tggttctcta gaactatctg cctcccataa tattactcag atcgtcgaag ttgtttctga 414661 tttcgaaaag agagatcgtt tgaacaagta cttagaaaca gcctctcaag acaacgaata 414721 caagacatta atctttgctt ctacgaaaag aatgtgcgat gatatcacca agtatctaag 414781 agaagatgga tggcccgcct tggctattca tggtgacaaa gaccaaagag aacgtgactg 414841 ggttctacaa gagtttagaa acggtagatc cccaattatg gttgctactg atgtggccgc 414901 cagaggtatc ggtatgttaa aattttctcc atttttttat tgattttatt tttttttgtt 414961 acccctaacg atattacagc tatttcctaa tggcttttaa tgacattaat gactttatga 415021 caaccatgat agtacagaag agagaccttt tttctttttt tttttttttt cttttttttt 415081 tttttttctt tttttctttt tttttttttt gagccttttc gaatctagac tctatgtgag 415141 tctattctcg atggggagta tcggaaattg aattttaatt cgaatgactt ctaatgcatc 415201 actacagaaa actaatattg ggaggatgag aaaaattgac tttaattagt cgttttgaga 415261 gacgggaaat tataaactcg gagaagtgta tttgtgttca tgatttgcac ttcatgtcaa 415321 aagaaatttc gctttttgac atcggcgcaa ataaacaagg aattggcttt tcagcttatt 415381 tctagaacgc atacatacgc ttcgttgatc gttgtttttt tcaatgcttg gcatttgtac 415441 aagggtagat tgttttattg gaaaaataat agtatattct actttgaaat gccgtcatcc 415501 ttcttgacta ttgttattct cattttgtgt agtttatgca ttttgtagtt atattgagat 415561 actgttgcat cccaagttcg aattattaag aagtgctgat aaaaatggaa aataacaaaa 415621 taaaaggatt tcaaccatat tcagaaatca tttactttgt tttccttttt ttaagtgcta 415681 gctttcattc agtttgaata aggattctgg agtattgatg attaaatatt tcgaattctt 415741 taataaaaat ataatttctg ataatcttca agccaggggg aaatttgaga caatgttggg 415801 agtccaaaca tgaatttgtg gggggcatga aaataaagtt catatacaga ataacgaacc 415861 aaattactaa cagtatgctt tgtaaacgtt tgtttacttc tttatttttt cagatgtcaa 415921 aggtatcaat tacgttatca actacgatat gccaggtaac attgaagatt atgttcacag 415981 aatcggtaga actggtagag caggtgctac tggtactgct atatctttct tcaccgaaca 416041 aaacaaaggt ttaggtgcta aattaatctc tatcatgaga gaagctaatc aaaatattcc 416101 tcccgaatta ttgaaatacg acaggagatc ttatggtggc ggtcacccaa gatacggtgg 416161 tggtcgtggt ggtcgtggtg gctatggccg tagaggtggt tacggtggtg gccgtggtgg 416221 ttacggcggt aacaggcaga gagatggtgg ctggggtaac agaggtcgtt caaactattg 416281 aagtcaaagt gattcaattc attcatctct attaataata attatataag ttgactgcac 416341 cttatttctt caatgcatga taaaatttta tttgctgtat actacatttt taatatttta 416401 aagctcttcg tcacactttt tctttaatac tcctaagttt ttgggtgaac ggtggcaact 416461 ggattgaagt tatttcgcat aacgcttagt gtgccgtaaa ataataggac agacactttt 416521 ctttgttctc gtacaaccct ggggccgatg ttaaacgaat gattttcaaa aaaacagtag 416581 acttacaaag aagtcgtgca ctagcgctta tgggtcattt tagaatgagc gaaatgcacg 416641 acaaccaggt tgatcgtatt gaagtaagag cagagcttta tttgcctttt ttttttttat 416701 ctaagacgat gatttttagc catacacaaa gataagtata tacatattaa tttataataa 416761 ttctatctgc caggcagatt ctatgataca gtgacatact tctatgcgat atagtagcat 416821 aagttaatgt tgtaagacat taatttggcc ttgattgctt gtaaataaat aatttaataa 416881 actgaaacga aaaattcaat tgagtttgga gaagagtgtg ggctattctg gaagaaaaat 416941 tattcgttca acaaataata agcaacacct agcattaaaa tggccaatat gacaaccaat 417001 gtaccactac ctttactttg gttttcagag gtagatacct tttccacaga aacgcgctca 417061 ctggtcttgt caacgtcacc aatgtataaa cctttcagta gtctcaatgc ttcgtcagaa 417121 tgaccgatat cgacaaagct ttctgtagca tcttgtccac ccaaatccat tataatttca 417181 tcaccacctg gatgttcatc tttgaattga gaaacatcgt aaactttgtc atcgatgata 417241 atccagaaat tttctgggcc attgtgttcg gcaacttctt ggtaactgta aactttaggc 417301 atgattgttt gatattttat gttgtagttg attgattttc tttactatga agaaaatgaa 417361 aatcgaattt aaatattaac gaggaagcct gaacgaaaat ttttgagaaa gtttcaaaag 417421 cttcttgttc tttatatagt tattggaaaa aggacaatat atatatttgt tatttattga 417481 tataataaca atgcttctca aatatcgctt tttggccacg aatgcgacaa aaattttctc 417541 gttatgctaa cctctctcac tatctcgatc tcgtatagct ttcttttttg cagctattgt 417601 tctttttctg ggccgttaaa tttttcatcc ggaaactcca ggctattacc cgctccgtga 417661 ttttggtcgt tgaatcttcg taaaagcaat catgtaaata tcattgaata cggacaaacg 417721 gaactatatt gctggaatta atgatataaa tggtttccca agtttgctat atctcctatt 417781 ctatcttaca aaaccctttt ctcagggtgg atgagaagtg acaagtcacc atttgaattc 417841 gatacctgac ttggctaatt tttttatcct ttcttcatgt ttttgcttca tgttatcctt 417901 tagctgtttt actggtttgg tgataccttt ctctactaga actctcttct tgtatttgta 417961 caatttctcg attttagctc cttttggtaa tacacgcact tgtagtagat gacccatcaa 418021 caagtaattg ttcatagatt cttgggcgat cattgcatcc tctttattaa cgaattctaa 418081 gaagccataa tgtctggaat ttccagtttt cttattacgt gctaatctca cttcttttaa 418141 atcaccgaat tgagcaaaat atttacttaa ttccttttcg tggaacccat gtggcagtct 418201 actcacataa ataatcccag aatactcttc aagtgtcttt ttatctttcg actttttttc 418261 attagcctgc ttcttaggat tcaatctttt aatcttgtgt gtaccgctct gctcatcatc 418321 agaagcggct aaaccttcaa tttcatcttc atctttttcg tcttcttcat ctgaactgct 418381 agacgatgtt tctagagcca actcttcttt ctcctgtata ggtttttctt cggtgggttg 418441 tttggttact gtttccttgg tggaagtttt gcttgttgac tttaccatat cgatctcttt 418501 cctctgttat tttatctcta gaacttaacc ctatagaaaa ggtagttaat gaagttaaaa 418561 gtaatggtaa tcgtcttcaa attaagtgat gagatgagat gcgatgcact acttcatttt 418621 ttcttatggc ggaaaatttt tcatagtgaa aagaaacagg caaaatctgg ggggtaaccg 418681 catacgtctc tgctatgccg tctgtaatga ggatgctaaa gttgcaatag ctgctatgca 418741 cattagaaag ggtttagcag gataatgagt tttcagagat agcacaaaac tcgaaaggtt 418801 tcggtactac tacctagaca gctcatcttt caatcgttga accttgaatt ttgaagttta 418861 gggatattaa aagatactgt taattctatc aatttacact agactttgac atatgtatat 418921 atatatatat attcacacag cttcatcatg aaataaaaat caaatgcaga agtgtataat 418981 gagaagtaca gaattcaaga ctcactttag ttttcactcc atttttagtt ttccgctctc 419041 agctgctctt ctcgctttga tatcagcgtc tgaaccagcc tcaaaggcat tcataaacgt 419101 ccaattcatt tcttccccat tagttaaaaa ggaggtgttg ccattcattg taagtttcca 419161 ctctctctct tcaaatggta tactttcatt ttctcctttc accagctcaa atttatcaat 419221 agcacaactt ccatttctta taaaggtgcc tttgttatca atgggctctt tggcactgga 419281 gaatttcaac aagttcatac caagagcgga tttagtggct gcgtgggtaa ctatcataat 419341 ggtctttaca tttggaaatt ttctctccac tctgtcaata aagacaggcc agaatttatg 419401 gcacctctca aaaatatctt cttctgtttc acccttatta ctaggaataa tactaggttc 419461 ccagtctgga gagatcatgc ttggaaaaaa cttactcata acttcatgag tagcaggctc 419521 cgggataatg ggtctatcag gcttatacca ttctcctaca ccacgatcga catataatgg 419581 aatctttaaa gcctccactg tgggtttact agtttctaaa cagcggtaaa atggggagga 419641 gaaaatcatt tctggtttga catctaattt agagatatag ttcgccagtt catgtgcctg 419701 ttcaacaccg tgttccgaaa gcgggacatc gttatcaata ccggtgggcg gtggtggata 419761 tggtcccttt ggtagccagt ttgacctgta accatgtctg gcaatgtata tattttcgat 419821 agccataatt tatagcacta ttttaacctc ttgtacaact aattgaacgt cttacatatt 419881 gaacgaaact gctttacttc taggattgtt ttcaaagctt ttttataaat ttcgaaatat 419941 ccgctattcg gatgacgtga tgacgcttcg gcaccattga ttatttttcc agagtttaga 420001 tgtcttctat gtgcaactga acaagtagcc ttcgaaagct agagggatag atacattact 420061 tgtgaccacc tatttacggc atcacaaaga aagcgagatg gctccgacaa taagcaaaag 420121 gataaaaact ctctccgtga gcagaccaat aatatatggc aatacggcta aaaagatggg 420181 tagcgttaaa ccaccaaatg ctcctgccga acatactcat ttatggacaa tttttgtcag 420241 gggcccacaa aatgaagata tatcgtactt tatcaagaaa gtcgttttta aacttcatga 420301 cacctaccca aaccctgtga gatccataga agcgcctccg tttgaactga ctgaaacagg 420361 gtggggtgaa tttgatataa atattaaggt ttattttgta gaagaggcca atgaaaaagt 420421 gttgaatttt taccatagat tacgacttca tccttatgct aatcctgtac cgaattccga 420481 caatggaaat gagcagaata caacagacca taatagtaaa gatgcagaag ttagttctgt 420541 gtattttgat gaaattgtat tcaatgagcc aaatgaagag tttttcaaaa ttttaatgag 420601 ccgaccagga aatttgttac cttcaaacaa aactgatgat tgtgtatact ccaagcaatt 420661 agaacaggaa gaaattgaca gaatagagat cggcatagaa aaggttgaca aggaaattga 420721 cgaattgaag cagaaactgg aaaacttggt aaaacaagaa gccattaacg gaagttagga 420781 tcactgcacc cggaacaacg gtattttcat aacagccata gtaatacaga tcatggtttg 420841 aaaggtcggc gctcacaaaa ccgaaatgtg tgcagagtca tataaacatc taaacaacag 420901 ttatgataca tattctataa atgcgtaatt ttagtaacac aatttaattg gggtcgcaag 420961 gcttcaatgg atgaacgctt agcttctcta gttcagggtt cttcgcagga acttttggtt 421021 tagacttttt cttgcaaggg agttcctctt cagattttga attcgacggg gaaactttta 421081 ttgagtgttc ttgagaggtg ttaagcttgt tagcagcaac acttaaataa tgcggttttt 421141 tgacaactgg tggcttctca ggttttgtgg aggcctttgc tggctcagga tcttctgtag 421201 tggacacacc tgaatttttg gtagatgtag agatttcgtc cggggcagta ctgctcttcc 421261 ttctaatagg aggacaaggt cgaggaacaa ttttcccatt atctatggtc tctttagcat 421321 gctgtaattc tgaagaactt ttctgtaaag agactggctt agataaagat aaagcgggca 421381 ctggcggcag tggtttgggt gtactgtgtc tctctaaggc aggaagattg ctctcacctt 421441 tacgcggcga tacgctgaca atggaaatct ctttggtagg ggaaagaagt ttagaagatg 421501 gttccttatt gtgcctcgag gtaggaggag gcggaggaag cacattgagc ttacttttat 421561 cgggtgatac gttactgagt cctccagggc caacaacaga cggttgggga ctgggaccag 421621 aaagtagagg cgaaacgcac gaggaagtat catctaggtc aattagtttt atgcccgctg 421681 attgaacggt tgcatctaag ggtatacttt ccttttgttt ttccattctt gcatgagaaa 421741 gttcgtcagg acctgtagtt agtgcttcgg gatgcgtatt cttatattct gcatacagct 421801 tctcaactag gttaagcttc tctttttcgt caacaaattt cacatttgcc ctatatgcag 421861 cataaactgg tttatgatcg cttattttta aaggtgcgtc cgaatatgcc aatggatgca 421921 ggttttcacc tttatatatg attctatcag tccaagacgg agttctcgcc ttttcagaag 421981 tatcataatt atctgtgcca taatcatatt tataggtcgg acggaattgg agggtcggtt 422041 ctttaaagcc ctgaaatacc actccttcat ttatttcttg agtcaactga tcatattgaa 422101 gcaatctatc aatatagcca tccttttgag cccttaattc tcttctaact tcatcatttg 422161 tcaaagttat cctgtagtta aggtcaccca accaaaacaa cgaatcatgg tgtggaattg 422221 tctttgatct tggaaaggtt atgttcctgt agatattgtt gtagtcattg cgacgttcgt 422281 caatgttact cgcacctgct gataaatgtg tattaacgaa acagaatgaa gttgccccat 422341 aatcgaatct aatggctact gcacctttgt ttccagtaat accaccaaac ccagtctttt 422401 tggtagaccc acctacctct tttatgttat aggctctatc tgatcttgca aaaaatagta 422461 tcaaaagaga ggacatctgt tccactctaa gtaaaagata tttttcttcg tattgattca 422521 aacagtcagt aaccatagtt tcccaaaaag aacttttcgt ataatctgca ttcaagatag 422581 accctgcggt caactctata acttcctgca accctaacac aacgacatca ggtttgaatt 422641 tatcgccgat tggaaataac cattttgaca aatctgctct tcgagagttt ccgttaacat 422701 tgaatgtacc gacaaacaaa tttatgttag aatgagtggt gaatttttcc tctgactcta 422761 acagcctttc attgacgtat tcgcagattg gatcataaag ttcaacaact tgctggtgcg 422821 gtagtttgcc caaaagtgtg tcaatatttt gctgttttcc tttatctaca aaattgttga 422881 tgtacattct actaacggac ttcgtcgcat cagaaagggc gccagaaaaa gacattttac 422941 ctttccttga ataggacgat ttcagagcat ttgtcccagt gtaaatttgt gatatctgat 423001 ctccgttgtc ggcccataaa gcattcacct tttgcacaaa ttcattatcg tcgatgaaac 423061 tactgggttt taccaatcgg aagtcttcca aaaatagttt gaaaacggcc agtgaaatcg 423121 tctgttggat caaatttgtt ctatctaaac aatccaagca attggttcta aagacaccgt 423181 cttgttcgga tattaatcgc ccttctttta catcgtatga aaagtaaccg gcgtccaaaa 423241 ttgtgtttct tattttaggg ataatcctac ttgcagctgc aaacccatct tgcgaagttt 423301 ctctatggaa atcaaagctt gttaggaaca catctctacc gattttcatt ttctcagaat 423361 ttttcaactg ttccttgtat cgcctcgata attgaatttc tgaagattta gtagacagca 423421 ggttgattat atgaactggc ccatacttct taaatagtct tataaaatgt tcatcaaacg 423481 tgggctgtgt tgcttcaaca gatctggtaa tttgaatctt tggactaatc aaagatgtat 423541 cctgctccca aaaaattgga aggcttcctc ttatctgcgt gaaagcataa caatactgag 423601 aagagtacat aatcatttct gtttcaacaa aatttgcgac atggccatca tcatctatac 423661 cacgtgcatt aaaccttgtg cctgctcttt tccaactttg cctggaaata atggtaagtc 423721 ctactttcaa cctattaata tagctaaaaa ttgtttcagc aaaccctcgg attacggtcg 423781 tgaggaatcc tcgttgatcc aatagttctt tggccgttac atctagtctg tctctgtatg 423841 tgatgatttc gtccataaga aacgagttcc acataaactc ccggtcaaaa tcatcaaaac 423901 tcaaagagtg ttccgtgaat ccacgtttct gcaatgtaca agttaaatca aaatcggtgc 423961 tgtaataaaa agatccattt gataatagct ttcttagttc atgacatgga tgcttgggag 424021 cttgttcttg agcattcaaa ctcctagagg aagaagaacg tagcgatgat ctagaagaat 424081 gtgtggaaat actaggaggc gagcttattg caaaatctcc atcattagta acaatcggat 424141 aaccggatga atcgatgtcc atgaaatccc atttagaatt atttaagcaa aaaaaatcca 424201 cagcatatat tttgttaacc gttttgtttg ggatcggctg ggccacctta gatttacctg 424261 ttatggttgc tatgaacata aggccttcaa tttctatgag accaataaaa ccgtatattt 424321 catggttaga tagtcttctg aaaccattac catttaattc agctttcgga accaattcca 424381 cggcacatgt agatctgcga gagttcttac tgtttattgg cctaaatacc agtccatgtg 424441 tttctgaaac tattgctatc tttctagttt gctgtttcga taggagtatt ttcatagcta 424501 ctgagtattt gtttttgatt ctgctgcctt tgcgtggcct ttgtcaccaa ttctgcgaac 424561 aaaaatatgt tgagactata tgaagcgagt acttattgtc ctttatgcct agttttccag 424621 ttaaatctct cttaataact ccaggtttgt ttcaatttcg tcactaaccg ccaaacaagt 424681 ttcgggtcac cccacacgta tttggttcaa gaatatacta aaaaaagaaa aacaagcact 424741 agccctagat atggaaaaaa agatattaaa acgtaattct aatttagaca tccgtgcttc 424801 tagtaattat atggttaaaa aaaaaggaaa ggaagtaaat aaataagtat agaaataaat 424861 agaagcgaat aagtcctgaa atacagaaaa gttcttatgc agagccagat gccgcagcat 424921 tcttaccttc gacctcggcc aaagatggaa tggacacatc accagaatgg ataatattgt 424981 taatggtggc aaagatggct ctcactgaag aatcaccgac atcttcggag acacctacac 425041 cccatttgta ggccttttcg ttgtcggcat tacgcctata cgatagatgg atgtaagaag 425101 cagcttgcgt agaagaacca gaacctagag aatgctctgt gtagtttgct acggcaaatc 425161 tcacgttcaa caagtttgat agggcgtcga ccaaagaaga gattggacca ttacctgtac 425221 cttcaatatc gacgatctgg tcgcctactt tgacttgacc agtgaacact ctacgttcag 425281 tgccgaattt ttcaacatta taattgacta aactaatagc ttggtactgt tcgtcattgt 425341 agttgtaagc ctctttgaat aacttggaaa tctcatctga ttttagttct ctacccaagg 425401 agtcagcatg gtcttgaacg gcgctagaaa attcgatttg catgtttctt ggtagatcca 425461 aacccaaaga tctcaaaata acccaagcgg caccaccttt accagactga gagttgactc 425521 tgatgacagc ttcgtaatca cggccaatgt cctttggatc caatggcaag tatgggattc 425581 tccattgagt ttcaccttga gcacgcttct tgttttgtaa gttgaaaccc ttcttaatgg 425641 cgtcttggtg agaaccggaa aaggcacaaa cgaccaagtc accgccgtat ggtgctcttt 425701 gcgatactgg gatcttatta caacgctcaa ccacatctag gacagaggtc aagtcagaga 425761 aatccaaatt aggagaaaca ccttgggtat acatattcat agcaacagta accaagtcca 425821 cattacctgt acgttcacca ttaccaaaga gacatccttc tacacggtcg gcacctgcaa 425881 gcatacctaa ctctgtggcg gcgacaccgc aaccacggtc attgtgacaa tgtgtagaga 425941 tgcaaacctt ctcacgctca gtaatatggg tagcgaagta ttcaatctga tcagcataaa 426001 catttggaga ggcaacttct acggtagcag gtaagttgaa aatgattgga ttttcctcgg 426061 taggttccca agccttctta acagcttcgc aaatttctac agcaaattca cctggagtat 426121 cactgaaaca ttcgggggaa aactcatagg accaacgagt ggcttgttgg gaagggtcat 426181 ccttagttag tttcctaact agtttggtgg cctctactgc cttggaaata gcttcctctc 426241 tagacatatt aaaaacaatt tcacggaaca tatcacttgt tgccaagtaa gtatgtatag 426301 tagccttttt agcacctgtt aatgcttcca ccgttctctt aatcaagtgt tctctagatt 426361 ggacaagaca ttgaatacta acatcgtctg gggcgttttc tacagcatat ctagtgaagt 426421 cgaaatctgt ttgagatgca gaggggaagg aaacctcgat ttctttgaac ccaatattga 426481 ccagcttgtg aaagtattct ttcttttgtt ccactgacat gggatccggc agagattggt 426541 taccatctct caaatctgtt gataaccaac gaggagccct cgtgatccgg ttatccggcc 426601 actttctatt agatagcttt ggagcgttaa atggcttgta cttggaggaa gggtccttaa 426661 gcatattttt ataggctagc ttcactggag gaataactct tgaggctctg gaggccgcat 426721 gctcagcaag agcaataata ctctctttaa ccatgattgt tccttgtctt tttgtaagga 426781 aaaagtctac agtaaacttc tagtgtgaga atcctttttt ttcttcaaaa aatacccttt 426841 gaaagaactg agtcacttac acgtaagttt ctttttactg gtcaagttga aaaataacca 426901 ataaatgatt atggaaagaa cgttgaaaga ggagagaggc tgacccaaga ggagaaaaca 426961 tcgaacctac gcgactccat agcgcacatc tcccatgcgc ccgtgcttat atatatataa 427021 atatacatac acacatacat gcacgcacat acatgcacgc gcatgacagt gactggccgt 427081 tactgtacaa ttttttcagc caagtatgac acacattcaa ctcagctttt ctgaggcctt 427141 ctttcttttc ctgcgcgtcg gtagagcgat gactaaccta ctactgtctc agagccggtc 427201 ccgctccggt agcaatcctg gggctggtca taacagccga gtggaagtgt caaagcggag 427261 aacagaagca taagctcaat cgctggacat acggatgctt atatacgtct tattgtcgtt 427321 gaaaaatatc gaatttttta cttcatttat cgaggcttct tcgagcactt ttccgctatg 427381 gctttttccc cgtttccttt taatcacgtg cgcgggtagc acccggcaca cagctggtgt 427441 ctcgtcgcac atgctattgt gtgtcatcgg gccacacaag catattgctt gaattttctt 427501 tcatcgttca acttaaatcc acccaatcta gatgtagccg tagcatgtaa taacgtatat 427561 ccttgtttac atgcatctgt gccaggtgaa acggtctgtt tgaacgcaca tcatttcata 427621 tattagtcaa ctcctgaagg tcttcttgcc tgtccgtcaa ctgtttagac agactctcgt 427681 caataaagcg cacttctgat aagcactttt attccttttt ttccactgtg aacgatgaag 427741 caggagcagt cccacgaagg cgactcatac agcacggaat tcataaatct ctttggcaaa 427801 gataccgcaa cacaccctag cagcaacaac ggtgctaata ataatggcat ggggagcacg 427861 aactcgttgg accagtttgt ggcaacagcc tcatcgtcat cttctctggt gaccagcagc 427921 gagaataggc gccccctaat aggtgacgtt accaataggg gcaacactaa cctatatgac 427981 cacgctgtca cgccagaaat actcttagaa cagttggcct acgtggataa cttcatacca 428041 tctctggata acgagttctc taatgtggat tggaatgtga ataccaccca taataatgca 428101 aacaataatg gcgcggacac tttcagcagc ataaatgcaa atccttttga cttggatgaa 428161 caactagcca ttgagttgag tgcgtttgcc gacgattctt tcatcttccc agacgaggat 428221 aagccgagca ataacaataa caacagcaat aatggtaatg acgaccatag caaccacgac 428281 gtattgcatg aggacccttc taccaataat agacaaagaa atcctcactt cttgactcaa 428341 agaaggaata ctttcctaac ttcccaatac gaccaatcaa agtctcgatt ttcgtccaaa 428401 aacaaaagaa atggcaataa cggcgaaaca aacaactttg gcgacaatat gcaaaataac 428461 catccttttg agccaaactt tatgggaagc ccttctcagt ttcccgctga cgcaactaat 428521 atgacatcaa tcgaccatgg cggcttcaca aatgttgaca ttacatcaac tgagaacaat 428581 actaccggtg acaatggagt ggatgcgcta tcaaatctac tacataggac aacacacaca 428641 ccgaaccgct cctcccccct aagcaatgtc acttctgctc aaaattcctc ttcacaacaa 428701 cgaaaacatt cggaaagcaa agtcgatagt aacagcgata ataacagctc caacaaagcc 428761 cccaatataa ctgttcctga ctattcaatt ataccaacct ctgttttagt aactctatta 428821 ccgagggtca acgtgcccaa cggcgcatat aactcgttga tcagcgcggg atttgacaat 428881 gatcaaatag atgctatagc cgcaataatg gcgtatcatc atcaaaaaaa gattagggaa 428941 aataacagta ataataataa aaacatcaac accaatgaca gtcaagaggc acccattcta 429001 aaaaacatca acgaactttt aagtgtctta ataccaccct ctccggctga aactgctgcg 429061 ccaactacct tatcaacgtc gccttcgttc aatgagcacg gtgtagtagc agaggcttct 429121 tttctaagct ccattttgga actgggcata aagcatccaa aaagtaataa tattcacaat 429181 caacgacaac cttcacgaaa cgatcataaa atatcaagag agagtgacgg taacaatgga 429241 aacgataatg tccatcataa taacgctgtt attaagtcaa gtacgacgcg tggagacgaa 429301 attgccaaga tacgatccga gccaacttta aatgcaagtt cttctgatca caaggaaaat 429361 agtttaaaaa gatcacactc cggagatttg aaaaataaaa aagtacccgt cgaccgcaag 429421 tattctgata atgaagacga tgaatatgac gatgcagatt tacacggctt tgaaaagaag 429481 caactgatca agaaagagtt aggggacgac gatgaagatt tattgataca gtcgaaaaaa 429541 tctcatcaaa aaaaaaaact aaaggaaaag gagttagaat catcgataca tgaactgacc 429601 gaaattgcag catccttaca aaaacggata catacgttag aaacggaaaa caagctttta 429661 aagaatttag ttctgagtag cggtgaaacg gaaggaataa aaaaagctga aagcttaaag 429721 aagcaaattt ttgagaaggt tcagaaagaa taaaataaca gactatacag tttaattata 429781 tatatatata tatatacgtg catttttctt aaagaaatat aacttttttc ttgtactgcc 429841 tgcaatctct attcttcatt catcacacat ctattcaaac gcgttaaaat ttttttgtta 429901 gcctataagt aaaacgcgtc gcgtgtatcc aattttactg aattaaattc tttactcatt 429961 ggatgatata tatcttcttg gtctagacaa cgaacacata ccaattcaga ctcacgagaa 430021 aaaaaactgt cttcactctg ctattagaaa ccaaatagta tcaaggcata aaataaacag 430081 tggaaaatgt cttctaaaag tgaaaaatta gaaaaattga gaaagctgca agccgctcga 430141 aatggtacat ccatcgatga ttacgaaggt gacgaatcag atggtgacag aatatacgac 430201 gaaatcgacg aaaaagaata cagggccaga aagcgccagg aattgctgca tgacgatttt 430261 gttgtagatg acgatggtgt aggctacgtc gatcgtggtg tcgaagaaga ttggagggaa 430321 gttgataaca gttcaagtga tgaagacact ggaaaccttg ctagcaagga ttctaaaagg 430381 aagaagaata taaaaaggga gaaagaccac cagattacag atatgctgcg aactcaacat 430441 tccaaatcaa cactgctagc acatgcaaaa aaatcccaaa aaaaaagtat ccccatcgat 430501 aattttgatg acattcttgg tgagtttgaa tctggtgaag tagaaaaacc caatatttta 430561 ctgccatcca aattaaggga aaatttaaat tcttcgccga ctagtgaatt taaatcgtca 430621 ataaagagag ttaacggaaa cgatgagtca agtcatgatg ccggtatttc taaaaaagtc 430681 aagattgatc cagattcaag tactgataaa tatttagaaa tcgaatcatc accgttaaaa 430741 ttacaaagca ggaaactgcg ctacgcaaat gatgtacagg atttattgga tgatgtggaa 430801 aattccccag tagtagccac aaagagacag aatgtacttc aagatacgtt actagcaaat 430861 ccaccatccg ctcaaagttt ggctgatgaa gaagatgatg aagatagtga tgaagatatt 430921 attctgaaaa gaagaactat gagaagtgtg acaacaacta gacgcgtgaa tatagactca 430981 agaagtaacc cttcaacttc accgtttgtc acagcacccg gaacgccaat cggtattaaa 431041 ggactaactc caagtaaatc tttgcagagc aacaccgatg ttgctacact tgcggttaat 431101 gtcaaaaagg aagatgtggt agatccggaa actgatactt tccaaatgtt ttggttggat 431161 tactgtgaag tgaacaacac tttgatttta tttggtaagg ttaaactaaa ggatgataat 431221 tgtgtgtcag ccatggttca aatcaacggt ctctgtagag agctattttt ccttccaaga 431281 gagggtaaaa cacctaccga tatacacgag gaaataattc cgttactgat ggataaatat 431341 ggactggata atatccgcgc taaacctcaa aaaatgaaat attcgtttga gcttcctgac 431401 attccatctg aaagtgatta tttgaaagtc ttacttccat accaaacacc gaagtccagt 431461 cgagacacca ttccatcgga tttatctagc gatacctttt atcatgtttt tggtgggaat 431521 tccaatattt ttgaaagttt tgttattcaa aataggatta tgggaccatg ctggttagat 431581 ataaagggag cagatttcaa ttcaattcgt aatgcttctc actgtgcggt tgaagtttcg 431641 gtagataagc ctcagaatat cacgcctact acaacaaaga caatgcctaa tctgagatgt 431701 ctatctttat cgattcagac gttaatgaat cccaaggaaa ataagcaaga gattgtttcg 431761 ataacgttat cagcatatag aaatatctcg ttggattcac cgatacctga aaatataaaa 431821 ccagacgact tgtgtacttt agtaaggccg cctcagtcaa ctagtttccc attaggttta 431881 gctgcactgg caaaacagaa actacccggt agagtcaggt tgttcaacaa cgaaaaggcc 431941 atgctatctt gtttttgtgc tatgttaaaa gtggaagacc cagatgttat cataggccat 432001 cgtttgcaaa atgtctactt agatgtttta gctcatagaa tgcatgatct caacattcca 432061 acgttcagct ctattggccg tcgtttaaga aggacttggc ctgaaaaatt cggtagagga 432121 aattcgaata tgaaccattt ttttattagt gacatttgct ctggtaggct gatatgtgat 432181 atcgccaatg aaatgggtca atcattaaca cccaaatgtc aaagttggga tctttcagag 432241 atgtatcaag ttacatgtga aaaggagcat aagccgttag atattgatta tcaaaatcca 432301 caataccaaa atgatgtaaa tagtatgaca atggccctac aagagaatat tactaattgt 432361 atgatttctg ctgaggtgtc ttatagaatt caattattaa ccttgactaa acagttgaca 432421 aatttggctg gtaatgcatg ggcccaaacg ctaggcggta caagagctgg tagaaatgag 432481 tatatcttac tacatgaatt ttcaagaaat ggttttattg ttcctgacaa agaaggcaat 432541 agaagtagag ctcagaaaca aagacaaaat gaagaaaatg ctgatgcacc agttaattct 432601 aaaaaggcaa aatatcaggg tggtttagtt tttgaacctg agaaaggtct tcataagaat 432661 tacgttttag tcatggactt taattctttg tatccatcta ttatccagga atttaatata 432721 tgttttacca ccgttgatag aaataaggaa gatatcgatg agttaccaag cgtacctcct 432781 tcagaggtgg atcagggtgt tttaccaagg ttattagcta atctggtgga tcgtcgacgt 432841 gaagttaaga aggtgatgaa aactgaaact gatccccata agcgagttca atgtgatatt 432901 cgtcaacaag ctctaaaatt gactgccaat tctatgtatg gttgtttggg ttatgttaac 432961 agtagatttt acgcaaagcc gctcgccatg ttagtcacta ataagggtcg tgagatttta 433021 atgaatacaa gacaactagc tgaaagtatg aatcttcttg tagtttatgg tgatacagat 433081 tcggtcatga tagataccgg ttgtgataat tatgcggatg caattaaaat tggcttggga 433141 tttaaaaggc tagtaaatga gcgctataga ttattggaga ttgatattga taatgttttt 433201 aagaagttac tattacatgc caagaaaaag tacgctgctt tgactgtaaa tttggacaaa 433261 aatggtaatg gaactactgt tctagaagtt aaagggttgg acatgaagcg tcgtgaattt 433321 tgtccacttt cgagggacgt ttctatacat gttttaaaca ccatcctgtc agataaggac 433381 ccagaagaag cattgcaaga agtgtatgat tacttagaag acatcagaat aaaagtggaa 433441 accaataaca ttagaattga taaatataag atcaatatga agctttcaaa agatcccaag 433501 gcctacccag gtggtaaaaa catgcctgca gtccaagtag ctctaagaat gcgtaaggct 433561 ggtagagttg ttaaagctgg ctctgtcatc acttttgtga tcacaaagca ggatgaaata 433621 gacaatgcag cggatacgcc ggctctttct gtggctgaac gtgcccatgc attgaatgag 433681 gtaatgatta aaagtaacaa tttgatacct gatccacaat attatctcga gaaacaaata 433741 ttcgcgccgg tagaaaggtt gttagaaaga attgatagct tcaacgtggt gcgtttgagt 433801 gaagcgcttg gtttagatag taaaaagtat tttagaagag agggcggtaa taacaatgga 433861 gaagatatta ataatttgca acccttagaa acaacaatta cagacgttga aaggtttaag 433921 gatactgtaa cattagaatt aagttgccca tcatgcgata aaaggtttcc atttggtggt 433981 attgtatctt caaattacta tcgcgtgtca tataatggtt tacagtgcaa gcattgtgag 434041 caacttttta ctcctcttca attaactagc caaatagagc attctataag ggcacacatt 434101 tccttatatt acgcagggtg gttacagtgt gatgacagca catgcggtat agttacaaga 434161 caagtctccg tttttggtaa gcgttgtttg aatgacggct gcacgggtgt catgagatac 434221 aaatacagtg acaagcaatt gtacaatcaa cttttatatt tcgattcttt attcgattgt 434281 gaaaaaaata aaaagcaaga attgaagcca atatatctac ccgatgatct cgactacccc 434341 aaggaacagc tgacagaatc atctattaag gctttaacag aacaaaacag agaactaatg 434401 gaaaccggcc ggagcgttgt tcaaaaatat ttgaacgatt gtggacgtcg ctacgttgat 434461 atgactagca tatttgattt catgctaaat taggtaagta ttttgtatgt gttgtgtgat 434521 ctcatgaata ttctatatag taagaaaaga atacaactgt acatacgcat cctactagat 434581 acctaatgta cagacatcgg aaggagcgct aggaagcttt tattattgaa ggttttcagc 434641 gatattctga gaatgttttt tcggctctgg tgatcagttc tcacatgcat catcctttaa 434701 taaacccatg cattaagatt cgccttatca gcaagatcag ataagcgaac agcttcatca 434761 atgaaataga atgcttaaat cttgtgaagc actgtcataa gccagtttga taaaagcaat 434821 acccacaata tagttggata tcatttacct tgatctgctc ttgctttcga ggtgacatag 434881 catttttagc catctgattc cttaggttca aaggcactca tcattcctcc tctaaaacac 434941 atttcaacgt cattcataat ctggaatcaa cataacaata tcctagaaca catcatcaat 435001 ggtcactaac aatggagatg gtgagcacct tgggatccga agaaacggaa atttaaggca 435061 tccttccaat aatatgaaaa ttcccagaag ggctcaatca acagttctca attcaaaccc 435121 attttatagt aggaagtatt ctatgtctac cttaacgccg agggatatat gtcgaagcgt 435181 tgattctaga gtatttgtgg atatgtcttc tcccaatttt cagactctgg aggatcccca 435241 cagagatgag attataaaca gtgtacggct taactacttg aacagtagca aaagaagttc 435301 cgtctctcat ggaaatgaag caatccctag ggttaatccg actaagaatt cttcagcaag 435361 taccatagct gcagcaaatg ttgatagtga tgacgatgag actaacctga gtagcgctgg 435421 aggcgacata acgcatgata tttacaagtt ggttaaagca gaggatccta aacggctcag 435481 acgccctcgg tccatggaaa atgtaacacc taaaattgag caccatacta aattgtcatc 435541 agcaagtggt ttaaatgtcc ccggtggctt cagaagggaa tttattgtca acaaaaaaag 435601 gcaagaacat caattaaatg attccgctag ctcagacttc acttcgcatg aaagcgattc 435661 gattaaccag tcatctccat cttctaacca agatatcgat aaggtcccct ttttaacaag 435721 aaactttttg gaatttctat acgtgtttgg acattttgct ggtgaatcct tcgaggatga 435781 ttttatccct gatagctcaa acatgatgat acgcggagaa gatgaaagga gtgcattgct 435841 gtctcggcct gaccatatga aagtattacc ttcagccaaa ggtacgactt cgacaaagaa 435901 ggtttttttg atattgctta aatctttcat tggaactggc gttttatttt tacctaatgc 435961 ctttcataat ggtggtttgt ttttctcagt aagtatgctg gccttttttg gaatttattc 436021 atactggtgt tactacatat tggtgcaggc caaatcttca tgcggtgtat cctcctttgg 436081 tgatattggt ttaaaactgt atggaccttg gatgagaata ataattcttt tctccctagt 436141 aataactcaa gttggattct ctggagctta tatgatattt actgcaaaaa atttacaagc 436201 ttttcttgat aacgtattcc atgtgggcgt cctaccttta tcttacctga tggtctttca 436261 aacgatcatt tttattccac tttcgtttat tagaaacatt tcgaaattgt cactaccatc 436321 tttactagca aattttttca tcatggctgg tttagtcatt gtcattattt ttacagccaa 436381 aaggttgttt tttgacctga tggggacccc agcaatgggt gtcgtctatg gcttaaatgc 436441 agaccgttgg acgctgttta tcgggacggc aatatttgct ttcgaaggaa tcgggttaat 436501 tattcctgtt caagactcaa tgagaaatcc tgaaaaattt cctttagtac ttgctttggt 436561 gattctaacg gcaaccatac ttttcatttc catagctaca ttgggatatt tggcatacgg 436621 ctcaaatgtt caaacggtta tactgttgaa cttacctcaa agtaacattt ttgtaaactt 436681 aatccagctg ttctattcca tcgcaattat gttgtccaca cctttgcagt tgtttccagc 436741 tattaaaatt attgaaaata agttttttcc aaagttcact aaaatatatg tcaagcacga 436801 tgatctaaca acaagagtcg aattacgtcc taattcagga aagctgaact ggaaaattaa 436861 atggctgaag aactttattc gttctataat cgtaatcatt gttgtatcaa ttgcttactt 436921 tgggtctgat aatttagaca agttcgtttc agttatagga tccctcgcct gtattccttt 436981 ggtatatata tacccatcga tgctgcattt acggggcaat agccttccag agactaaagg 437041 ggaattttgg agattcaaac caatgttaga taccatttta attttcttcg gtattgcaag 437101 catgctttat acgtcttacc agagtatatt cggtgtctag acgatatatg ttgttgcttc 437161 ataaagaatt tatttggaat cgaggaacac tattttgcca ttgtcgccat tgacagcttg 437221 cagttgcaaa cgtcttctta attcacttta tataaacaag gaccgccagg tcacagtatt 437281 attcgcacga aattatgtag taggtaaaaa acactaaaag cattacccct atattgttat 437341 ttaatgttcc atctacgatt agtaggtggt gagcatgtct gaatatacac aatttcatat 437401 ttattatcaa gttcaagatt gccagaattt tatttttttt tccaatctgc gaataagctt 437461 gatccgatta ctccgcttaa tgccccgaca acctgagaac ttttaaacat atcaaggagt 437521 agagtgggat taatgacaat gtgatagttt cataattaaa gtaagcagtc aaagacagaa 437581 gcagcacacc atttaccaat acagcttcca aaatggtaaa tttttatgat gacgtggatg 437641 agtcgaaatc acacggtgaa ttcccattaa tacccgttgt gcttcaaaat tcatcagagc 437701 tatcagtcag aactatacct accgggaatg aaatcattga gtcagtgcac ctgaccaaat 437761 ggttacggaa atatagaaac gcacttgcca gtcaactaga tcgttatgag aaggggtggc 437821 aatccaagat agccaacttt aggctccagg tccaacatgt tatcaattat tcgagaaaga 437881 atattttcaa tgttgattct gaaaataaac atactgtggt cccggggtca ttaatagcgt 437941 taggtgcctt ttttgctgga agcatagctg tgaacaggtc taattgggga gctaaaaggt 438001 tgatatttgg tcacaaatct agtatcctcg agaaactatg tacgtcattg ccatctagga 438061 tattgttacc atgggtattg gcagcagcta cattcaagta ttgggctcca cagacatcac 438121 agaatttggt caatgccact gaaaatgatt tactgccagc tgatttcgtc aagtcatatc 438181 acaatacttg gaaacgaatt tatgaggaag gatatgttgc caagaaatgt gatttaaaac 438241 gtcaaatcga tcagacatta caaaaaaata taaggtatgc aagggaacag ctttatgaaa 438301 agttggagca agcatgatat caagcggata tctttttttg ttcattatca tgtccatagt 438361 aagtatgtcc atatataaat cggataatta atattctata aaattaccca ttaaataaat 438421 ttcatttatt ttgaatttca tttcgtgtga tctttagaag ttggttcgcg aatgggccgt 438481 gcatcctgaa acatttcaaa ctttaggtaa atggtcataa agctcagtgc tttttcttta 438541 tcttttgcat tttttttttc ttgcctctac tccaaagctg tcagtaacca acttggtgct 438601 ttatttttgt ctatttttac taaattagtg tcgaaagctt ctataagcaa ctctacaaga 438661 attctaccac ctctgctacc agtaaagcgt ctatattctt cggatacact ggctaagttc 438721 caacccatta ttcttctgag acatccaatg actgtcccag tcctatgtct tcccatacca 438781 cagcacacta gcaagggata attctcttga gtgacgatcg tttgtagtac attaattata 438841 gaatgttcag tgagaccgtc ccatggatta tcgtcctcac cggcatccgg gttgatggct 438901 gcgaattgta agtttattct atgagtatca caaaactcta ggagggtatc ttgaggttct 438961 tcgttagaca gccatataat tgttttcagt tttaggttta gtaaaaaggg gaaattcaca 439021 ggtgaaggct gaccagatct atagaggtat ctttcaacgg gacagaaatt caaaggtgga 439081 acgatacgtt cttgtggggc atgtgatacc aagacctttt cgcgaccaga ttctgtttct 439141 tcattgatat atatatgatc atcatcgtcg tcttcttcct cgtcttcgtc ttctacttct 439201 tcttcaggta cggatacgtt ctcttctgtg aggcgggact catcctctgg aacgtcctca 439261 tattcaccaa ctttagatgt cattctaagg ggaaagagaa gcttgttatt ccaggtggaa 439321 cacctctttc ttgtgaaaat ggatgtgatt gatgactctc tgcaatgtcc aattttatgt 439381 tatagcgatg ttgtttgttt tttcctttac ccggcaacca tatgatattg cccaaagttt 439441 ccaatgttaa caagaatgaa acggaaatag caaatggcaa taagcaatat aaaaacagtc 439501 acttttttat ttacttttgt atatatttat aaatgtgtgt actcgtttca actttataga 439561 gttcttttcg tcttagcgtt tctacaacta tttccttttt attaacttat aatacaacag 439621 ccacccgatc cgctcttgga ggcttcactg gtgttaccgc cgggtgcagc ttgctgcttc 439681 ctagcctgtt tagcatttga aacttgaccg gccttactat tattatttac acgattatta 439741 accgtattag cgctttgagc gttggcctga ccagcttggc ccgtggaatt gtctatattg 439801 gtgcgatcag tttgtgtctt accatttgtc gcctggttgc ctgccaaccc tgtcttactc 439861 tctatgcttg cattcctggc attcacgaca gttgtgctac tgttcacatt tttaccgttg 439921 gcagcattgc tcatcttcct gtggccaccg ctatttctag gcacagagtt ggcaccgctc 439981 ccttttgtat cttgagaagt ttgcttggag ttgtcatttt ccgtcaaagt cttgttgtac 440041 ttgccgcctt cgtctctaac taaacgtgct agagtgtaaa acgcctcttc cacgttgatt 440101 gcttgcttag cagatgtctc caagaaagga gcgttcattt gctttgccat gttcaacccg 440161 tcctggtaag agacctgttt ttcgttttct aaatcagatt tgttaccaac aaccacaatt 440221 ggaacatagt cggtatcttt gactctcaat atctgttgat agtaagtcat aagctcatca 440281 agagacgact tggacgttat agagtaaacc aataggaatc cttcgccgtt gcgcatgtat 440341 tgttccctca tagcagagta ttcttcctgc cctgcagtat ccaaaatgtc caatatagac 440401 acttcatcat caatcaccac ttgcttcctg tatgaatcct caattgtggg atcgtattca 440461 tctacaaagt gcgattgggt caattgtatg gtcaaagcag atttaccaac accaccacca 440521 ccaacgacga ctagcttgta ctctcttatg ttcgacttgt tcaaaggcat ttttttttct 440581 gtatatctcc tttcaattcg aaaacggtta acttggtttt tttatccgta attctctcgt 440641 atctttctgc tcaagtaatt ttctcctagt tgattaatat agtgcagaag agtcagataa 440701 agagtggatg aataaaatgg aaaaaaaaca aaagccggat tgcgttacgc ttgaaatgag 440761 cgattctagg cgataagaga agacaacggc taaaacttaa gatgttgggg tactataaat 440821 gtttacccag attttcggta gaaatgtttg ctgatgtgaa ccttgtttcc cgttttccca 440881 gatcccctta ttccagcttt gtttcgtctt tgctgtcatg ttccgtttaa tttctgaagg 440941 cctgcctagc ttcaccgtcc taaatgtcac gctccaggca gagacatggc gcaggggcga 441001 ggccaggggc aaaggggtca ggcaggaacc tccaaggggg gcgaggtgaa tgaaaaggtc 441061 cttctgaata aaaagcctaa gcgattagcc acaccaccca ctgtacggcg attagactga 441121 gctgctggcg ctgctacgcc gtgacaagtc atttcatcat ttattacgtt ttatcgtgcc 441181 gtcatcacca tcgatttgaa tattttatct agaccggtag ggcccaagta tcttgcagat 441241 ccattgatac ggccacgccc gttaaaacgc taagatatat atatatgtag ctaagatata 441301 tatatatgta tatattcggt atttagtaga tatttcctta aggcgatatt cgcccgagag 441361 ctatttcaca gttttttttt gcagtcgtcg caataccact tgcccttagg tagagtttcg 441421 agtccaatac atggcaaatg gaaccattct agctcacagt ctgcgccatc acaccccacc 441481 atttccccgt atgccacttg gttacagtag cagtagagcg gttcgccgta gtcgttggtt 441541 tttggtcttg atatcctgct gttgttgctg tttccgacgc tgctaactcc cctggacgct 441601 gtagatgtac ctatcctgcc attattgacg gcagttgccg tgctgatagt gcttggtgaa 441661 acggctgtgg tggcaactct cctcttgcgt tttttggtct ctggatcggc gttgttggta 441721 ttggcagcgt tggctctttt tcttgagttt gtgttgttac cagtgtggtc ttggctctcg 441781 tgcctgctgc ctccgtagtt tgcgtcgttc tttgagtcgt cttgttggtg tgtgctggcg 441841 gagtaatgtt cgccctgcct cctgttggca gccatggctt ctcttcttga ttcgctcttc 441901 agtgcctgcg acgatttgct gtttgatttg ctctctattt tttccattag ttcatgatgg 441961 aggtgcattg ctggatggtt gtccacaccc agtcttaaac ctctaggaat ttctgtgttc 442021 ttgattgcga cttcatacgc caattctaac cgggacgtca atctgtctag attatccagc 442081 ataatggatg agacatgcat tttctcctcc agcgatggca tcagttcttc ataaatcttg 442141 ttgatattat tgagcagtct tacttgtgtt tggtgatctt tattgaagtc tttcttcaag 442201 aacttatcta tcctctcgtt caaattcggc atagaatgca cacattttgc atctatttcg 442261 tgtagtaatg ttaaatatct ggaggtggcc agtgggaatt cctccagcac gtcagttatg 442321 tcgtttaatc cagggaatag gttcgctggt gaactcattt gtacgtattt cagactatga 442381 acgtggttgc tgtttgtgat actgcaagac tacaaacttt tctccttccg ggttcgtcct 442441 gttgtaaacg cctaactctt ttccttaggc tcctttttcg ttttttccct agctctttct 442501 ttcttcttca tgtgcatgca ctctttccta catatttttt tttcaagggc atttttaact 442561 ttcttcggaa atcgtctaag aattgtaaac tataattgca aatacgcgat tagctctatc 442621 tagaataccg aaaaaaaggt ttgccactca caattggacg tgcctcaatt atttcaagta 442681 tacgtcattt gggcttttga cttgtaaaat atactcaaat gaaattctga ttatacaaag 442741 ttgaaacacg taacacgcca tgtcaaggta cgcgtagagg taagcagata atgcatggac 442801 aatgtgctgg gcgaagaggc ggatctaatt acacatactt gggatcatct aagatttcag 442861 atggttatgt taatgctcac ttgttccacg cctttttcct ttccttcaga taagtaatcc 442921 gcatatcaat gtgaaagaac taacggttgt tgatggacgt atcgttgtct agcgataaat 442981 aatgcttttt cttcaacaaa taagtggttg tttggccgag cggtctaagg cgcctgattc 443041 aagaaatatc ttgaccgcag ttaactgtgg gaatactcag gtatcgtaag atgcaagagt 443101 tcgaatctct tagcaaccat tatttttttt cctttttatc tgattgcagc gagaacttgg 443161 gaaatcaacc caatatgtat tccaaaatgt caaaacacca attaaagcat ctctatattg 443221 acagatacaa aatatattta agtatacatt cataattatt ttactcgaat taaaaaagcc 443281 cactttttgg aaacctcctt ttgtattctc ataactatgt ttcttttttt attatttttt 443341 cttaatatta ttttctttaa gtatgacaaa tgatgagaat gatagttatc tcactattta 443401 gttggtctgg cttggaattt caaaaacaat ttgtttgcca gtcaacttgt tgtagacagc 443461 ttggaaagat tccaacttgt agtcgatttg ttgaacatcc ttggagtcta acaaaacctt 443521 ttggatcttg ttaccaccaa ccaaatatct aactctttta ccgacaattt cagttgggaa 443581 aaccatgtct tccaaaacct tgtcgtgaac agcagtcaaa gttctggatc ttggtctctt 443641 ttggacttgt ctagatgttc tagatggttt tggcaagatt cttctttcag ccaagaaaat 443701 aacatgacgg tcagggaatt tcttttccaa ttcacgggtc aatttggttt ggaccttatg 443761 gtatgcagac aaagctggaa ctgggacaaa aaggactagt gctttcttac caccggtgac 443821 atcaatctaa acaataagaa tcaagcagcg ttgaaataaa gttagtaact gaattggttc 443881 attcataaca aaaaagggtt tgtgattctt ctccttgggg taaggtcttt ttcgcgtgct 443941 tctattttat tcatcgatat tggtactgac caaggaggcc tttatagttc aaaggctcat 444001 cgcaacgttc atggtattga cagctctcgg aattactatt tttctcgaac acatgaaaat 444061 ttcatacaga tactgctcaa aatcactctt ttttgaaaaa attactgcaa agaacccctt 444121 tagaagaaat cacaatgttg ctgcttccaa attatataac ttttaacata cttctctgat 444181 agatttgatt tgcaatggtc tcaagtcagc ctttagttct ggagaggagc tttctagatc 444241 gatgaaggtc ttggcgactt gtaattccaa ctcacttgga gcttgggata agatcttgga 444301 ttggacagag gacattggtc agttatgtgt ctagtcttta gtgtgttggt ttctcttctg 444361 tttgtatata caaagtcaaa taacacatat tttaaccata atcaatagca tttggtattt 444421 ccccctccgc gtattatgaa cgcctagtga gcccattctt ccctaaagcc aggctggaaa 444481 cccaaactgt gtggaacgtg actgaattgc atttggtgag ttaccaagca aaggctcgca 444541 ggcttgaacc acattttacc agggcgctcg ctttttccga aatattgaaa ttaagcaaaa 444601 caataatgta cggatttaaa gaggtacgga tggagaccgt agaaaattga cttttttttt 444661 ttttttgtta ttttctgtgc ctttcgtaac tactactatg cagaatgaca ggtagttgtt 444721 gtttcgaatt gctactttca cgcattcaac ttgatcaaca tttctctctg atgaaaggtt 444781 gtggaaagtt tggtcgtgtc tataagtagg tgttttttat tagttctata taaaaatgga 444841 gaatgttaat tttaacccac cctaaaacag tgattaggag tggtaataat tttttgttta 444901 atggattaaa actaaaggtt catctgtact ttcagaaagt aagacactaa aaatggcaag 444961 ctaacaacca ttagcgggta ttgcagcatt aagaaaaatg aaacacactc catttggatt 445021 ggcgcagttg tttctggcgg cgtaaaactg gcggtgaaat atataagggt agtcatcgtt 445081 ggcaagttcc agctgattgc tataacaaat agtagcattc tatcatcttg ccaattaacc 445141 catccagctt tcactaaccg atcacaccat aggacaccaa aaattggcat gacacattgt 445201 ctcaaaatga cgagtgtcac agcggctttc caaaatccag gataaaggtt gccaatcttt 445261 aatcttccta aagttgctcc taataatatc aacccaaatg gaacacatgc ggcaccgaca 445321 taacctgtaa aatccatgaa aaagcttaat ggtggtgcat tgtcaggagc ttggcttatg 445381 tgaggagtat tagcggtagt cacgaacaaa gccttgaccc atgggataaa tgcaacagtt 445441 agggcgatga tcacggccat agagcacggt ctcaaacaat tctttaggaa aaacacaagt 445501 aatggagtta atgaaaattt tctcatccac tgtggtaatg attcgccgga tgtttcaata 445561 tcctttttac ttacagtggc atctgatgtt aagatcctgg ttaggttagc agtttttata 445621 gtctgtaaag tggaatttga gctaattgaa tgcacatcat tcatatcagc gccgcgtaaa 445681 ctggaattcc tcctttgatg accatactgg tcaacgttgg agtactctct gataagatgg 445741 tgtatatttt gagaaggtaa tgcacgcata tcaatggagc ggataggttc caatgccgcc 445801 atagacatat tttttgggca tttttcatct aaacagttct cttctaggag tgtggtagta 445861 ttgtaagctc tcggctggct cgcggttcta cgtgctctca tagtatctat gctactctca 445921 taactctctg acgtattata agaatgtatt gttgaagcag atgattggct atctaatgga 445981 tttgaaccac gagttgcctg tgactcttcg ctttgagtgc acgcaatagt atttcttgcc 446041 ttcacctgaa ctggttttgt aatctttgaa ttcgaagaag tgtctggtag tgacagggga 446101 gctatactat ttgttgatct ccttgaaatt ggtggtacgt ctgcgttttc accctttgta 446161 cctatagctt cagtgagact atcgcgagcg gtgtacttat tgttgaaaag ctgttgttcg 446221 tttgagaaga aacgctcgct agtatctgta ttagttgtgt ttgcacttac tgcgggctgt 446281 gtctttgtcg tttctgaaac cctaacggcg ctttcatcgt cgttgtactc gaaatcgctt 446341 tcaatcagtc gaaacccccc caaattgaaa atgcaaatta gaaacattgt cagaaatata 446401 atgacgttag ccacaccttt gttaccttct tcttccgaaa atacaagccc ttggtccata 446461 gattgtaaat atgcaattgg taaatcactt atatttggaa acataccacc ggcaagaata 446521 ccaccgtacc attgtttagg aacaggcagg aatagcctaa caacgtatgc aaaaaagaac 446581 ccagaaccaa atattaggag ggcagacaga cagataattc ccacagattt gatgtcttta 446641 tcttcaatat tagcgacaat cttgttgaat gacagagagg gtagtaaaac tgttagcacg 446701 atatcagaaa taattcttgt tgcttcaacc gtaagaattc ccattttagc catcagaaag 446761 ccgactccta taatcaaata aatcttgatt atcggcttaa ctgacaccca tatcgcttga 446821 cccagagtaa tgtgcaccat ctgatgaaaa tttgaggttt caatcccttt ctctgtttga 446881 ttctataact tctccaaaaa aattgcgctg acgctaatta gtcactgttt atatcttttt 446941 tagcgatgat ttgtaacaat atgccataaa agcgttctct aactgcggaa gtgatgagaa 447001 ttgaatagtt ttattcagaa ggcaatatat cctaatatgg cacaaaaagg caacttgtat 447061 gcacaaaatg agcataagag ttcaggcaga acgttgtgct cttgatccaa aggttaaaag 447121 tcatcgagta ggaagatatt gtaaccttcg cgcaaaccgc agccgcagcg ggtcacgtgg 447181 tcgcgcaaat gatgatgagg gcgcggtcta actttccaaa cgaggttacc aacaattctc 447241 ggacagataa agcattagaa tagggtggca acgcctttac ggttagcttg ttcattgtga 447301 ttggtttgtg tatcttttct tggcttttta tgcccacgag acataaagta tacgaagctg 447361 ttatactatt cgtgatccag ggcaaaaatt tagcatcatt aaggcatata tatcgcaaat 447421 agtgggttgc acaaggcttt caataaacag tgtcatatgt ttctctagct ctgtcggttt 447481 gttggctata aagagtttgt ctagtaatcg ccgtcttttc ttgggaccat taacacagac 447541 aaggacattg aaacttggct ataagttccg tcaaaggggg aaaaaattgc tttggagaag 447601 gaataaaaag atgaatagtc aaggttacga tgaaagctct tcctctactg ctgctactag 447661 cggtcctact tctggagacc cacgaatggg taagaaacaa cggtttatga atctcataag 447721 aaccacaaag gatgtttata ttcctaacct gacgtcatcc atttctcaaa agacaatgga 447781 tggcatcagg agcactacga attccttcga aggttataat gacttgccta tggaattgcc 447841 acataatacc acgataacat attttccaac gtataccaca actaatttgg ttgaccctga 447901 cggtttgagt gcgcctcgga aagattttga aactactgtc agatgtgctg tttcttatcc 447961 aggaaatcct acaagcagga gaaataggtg gttgctttct ctttgtaaac aatatcttag 448021 aactggaacg gcggaggccg atgttgcacc tgttgttccc cctcatctcg aagaggattc 448081 tggagattta aacgactccc aatcaagtat agaaagttct ttgtcttcaa agagcgaaaa 448141 taggtattca catatgggca tccaagagga agatgttctg aatgagagaa ttcaaggatt 448201 cctgtccaaa aaagttccta atactccagt ggtggttgac ctattgccca aagataagct 448261 cagaggggat acggcttcct tttttggtac cacggactct tatggtaatt tactaatcaa 448321 ggcagaaaca gattttttac cgtccaagat taatattaca ttagataccc ctatagaagg 448381 ccatgcagat cccatatctg aaacatttcc ggccaattat gtctcgccct acggtattgg 448441 tttaatcagt gatattgacg acaccatcaa gcatactggc gttacgggtg acaggagatc 448501 gatgtttcgt aatgttttca tccatgatgt tcaatcgtgg gtaatagatg gtgttcctct 448561 ttggtacaaa actttacatg atgtcgcaga cgttgatttc ttttatgttt ctaattcacc 448621 catccaaact tttactcttt tgaaacaata tatttgcgcc aattttcctc cgggtccaat 448681 ttttttgaaa caatactctg gtaatttctt ttccactatc atgacttcaa gtgcgaatag 448741 aaaaattcag ccgattgcaa atatcttaaa ggattttccc aaaaaaaaat ttattttggt 448801 cggtgattct ggtgaacatg acttagaagc gtataccact acggctttac aatttccgaa 448861 ccagattctg gctatttata taagatgttg ctctaattcc atgagtgatg tcccatcgca 448921 tgatgaagaa gttatgaatg aagtgaacaa tatcatcgaa ttacaacaac ggcccatgca 448981 aatgaccaag tctaccgtac gtaccaggag aagaccacca ccacctccca ttccttccac 449041 tcaaaagcca tcgttgacag aagagcaaac cgaaagtata agaatgtcac gccgtaataa 449101 agatgagaac aatgctaaaa gagttgcccc accaccgttg ccgaacagac agttacctaa 449161 cttagacgct aatacttact atgtaccatc ctcacaaaat gactatggca tgtatggtgc 449221 tttcatggat aaaaaagcag atgaatggaa gagaagagta atggactcaa ttcaaaaatt 449281 gagcaatcaa gacaccacat tgatgttctt ttcggatccg gcattaagtt tggaagacag 449341 tattcgcaga attagggaga agtattcaaa ctaaatacac tgttatttat atacatcggg 449401 agggagttta aaaattgtat acactaaagt gaccttatga attggagcca ttttcaacgt 449461 tttagagtga tgttgcatcc ttttcatcag atcgggaaat taaaaaaacg gttatagaag 449521 ggctaaatgt aaatatgtaa attttatgaa gtcaagagta aagaaaatct tcggttgccg 449581 atcaaataca ctcttacaaa ataccctaaa ctcagtttat ctttccattc caactgatta 449641 tcgcgtacgc cttggtgacc aaccataccc taaaatgtca atttccgggg cggaaggggt 449701 ccttaaactg caaagcctct tcccatgtaa ataaaataaa tccgtagaat ttattaaata 449761 ttgtcatatt ataagtcggg aaaggccttc tgaatgcacg tatattgacc aaatagagtt 449821 agattcaaat tatttattac attttttcag catcgaagtt aagtagaatg gataaacata 449881 cagcagctat tccaacatta actatcaaag tagtcttact cggagaatct gctgtcggga 449941 agtcctcaat agtcctcagg tttgtatctg acgattttaa agagagcaaa gaacctacta 450001 ttggtgccgc atttttaaca aagagaatta caagggatgg caaggtcatt aaatttgaaa 450061 tatgggatac ggcaggccag gagagatttg ctcctttagc gcctatgtac tacagaaatg 450121 ctcaagctgc tttggtagtt tttgatgtta ctaatgaagg gtctttttat aaggctcaaa 450181 actgggtcga agaactacac gagaaggtag gacatgatat cgttattgcc ttggtgggga 450241 acaaaatgga tttgctgaat aatgatgacg agaatgaaaa tagggctatg aaagcaccag 450301 ctgtacaaaa tctctgtgaa agagagaacc tcttatattt cgaagcaagc gctaagactg 450361 gtgagaatat ttaccagata tttcaaacat taggcgaaaa agtaccatgt cctgaacaaa 450421 atacacgaca aagctctact catgatcgca caattaccga taatcaacga atcgatctcg 450481 aatcaacgac tgtagaaagt actagggaga ctgggggttg taactgctaa actgcaagca 450541 aaacaacagc aaacgcggca tattcagcgt cttagcgaag cttgccattg aaaagaacag 450601 ttcgtaacaa cagctggaag aatagtactg gaaattttca attacttttg caaaacaagc 450661 acttttttgt ttcacttcca ttagccgcaa gaaatacact ttttttaggg gcgggaattt 450721 tcatcgccag atcgagaatc acaaggcctt tacgtactat agtttgtaat ttatacaaaa 450781 tcagctactg ttattttggt gtaccagcgg caaaaattgg tgaggatctg aaaattaatt 450841 agaggtgaac acatatcagt aattttgact atggacgaga atgaatttga taatcaaagg 450901 gagaataaag ctgtagctcg agtgatcata tcatttctta agtatgaaga gtatgcccta 450961 aaggaaatct acaatttgag agtgaaaaaa tgggcatcga tctcagatcg tcaaaaagac 451021 atggtaccaa actatacaaa atatttagct aatctgaaag ccgcaattat agaaaatggc 451081 aagttcttta gaagtgtcgc cgaatatgcc ctgcaatcaa taagttttga gccaggagaa 451141 atcgtacaac caaacgattt agatatgagt aaaacatgct ctttacttac gcaagtttat 451201 agggagtggt ccgcagaggc catttctgaa cgtaattgct taaattcgag gcttgtaccg 451261 tttttgaaga ccctatcacc cccaaaagcc gacattttga taccgggttg cggcacagga 451321 cgccttctcg tggatcttag cagaatgggc tataattgtg aaggtaacga attttcatat 451381 cacatgctgc ttgtatctca atacatgttg aatgcaggat tactccaaaa ccaaattatt 451441 atctatccct tcatacactg tttctcccac tggaaaaaaa ttgaagatca gttgtctccc 451501 attaaggtgc cggacataga agcgtggtct tcaaataaag gtatggggtc catgtcgata 451561 tgtgctggct cgtttgttga ttgttatggt cgtaatcaag gcacaaaaat ctcgtcacat 451621 tatacatttt cgcgaaggat gcaactaagt agagcaaaag ctgaaaactc caaagacgtt 451681 gtagtaacaa acttttttat agatacggga tccaacatct tggattattt ggatactatt 451741 ggccacgtct tgaagccagg cggaatctgg tgcaatttcg gcccattgct ttatcatttt 451801 gaaaatgacc atggggttga aactacctac gaagttaacc cttactctgg gtttcaagat 451861 aaaatcaatg actatacacc actgatgggt ttagagcttt ctagcgatga tatcataagc 451921 attgccacaa atcatctgga ctttgaatta atacggagag agtcaggaat actttgtggg 451981 tatggccgct acgcgggtcc agaaagttgc gccatgcctg gatacatgtg ccactattgg 452041 atcctgaagt cgaaccccac caatgaatca taagcttaca caataatcta attgcactat 452101 atagaagttg ctgacacagc cgttttagag aactcagaat gttacccgcg cggaaaattc 452161 tttttgctcc ctctcgctat gttctgttta ccatattgac agtactggtt atcagcctag 452221 atccagtaat acataaagcc ctcaatttga actatatatc aaagctagaa gaagagtgat 452281 ttgtcataat tgattcactt tataagctcc tttatcgttt cagtttccag gtgcatttat 452341 cgcttaaggc cattactttc aacaataagc aatctttata agtgaaaaat tggggaaatt 452401 gccaaagatg cccccaaact ccaagagtaa gagaagaaag aacaaatcca agcaacacaa 452461 caagaaaaat ggcaactctg atcctgaaca aagtataaat cctacacagc tagtacctcg 452521 aatggagcca gagttgtatc atacagaatc ggattaccca acttcaagag taataaaaag 452581 agcgcccaat ggcgatgtca tcgtggaacc aataaataca gacgatgata agaaagaacg 452641 tacggcgaac ttgactcata ataaggatag tatggattct gcttcttcct tagcttttac 452701 tctagattct cactgggaat cattatcgcc agaagaaaag aaaactattc tacgaatcga 452761 aaaggaggaa gtatttaatg tcataaggaa ttaccaggac gatcatagtt gtagttgctc 452821 tgtttgtgga cgccgccatt tagcaatgga tcaagaaatg gagcgtatat acaatacact 452881 ttatgccatg gataaggata aagaccctga aaccaatcct atcaaattcc acttaggcat 452941 aataaaggag ctacagattt ccaaaaatca acagcaaaat gatttatctt ctacaaaggg 453001 cgaagttgta aaaaatttcc tttcgtcaag tacagttggc tctttgaaag aggaagtgct 453061 gcatttcaaa caaaagcaac tttcaaaaca agaacaagcg cataatgaaa cggcggataa 453121 tacctcatta cttgaagaaa atttgaacaa tatacacatc aacaaaactt ctagtgaaat 453181 ttccgcaaat ttcaattctg tgagcgatga agagttgcaa caaaaatatt ccaacttcac 453241 aaaaacgttt atttcatcac atcccaaaat agcagaggag tatgtacaaa aaatgatgat 453301 gtatccgaat attagagcac tgactgatga cttaatgaat agtaacgggc aaggatttct 453361 taatgcaatc gaagactttg tgcgagatgg ccagatacaa gcatcgaaaa aagacgacag 453421 catcactgaa gatgaagcat ctagtacaga tttgactgat ccaaaggagt ttaccacaat 453481 gctgcatagt ggaaaaccac ttacagaaga tgagtatgcc gacctccagc gcaacattgc 453541 tgaaaggatg actaatgcgt acgataccgc aagtaagaaa ttcaaagatg tgtcacaatt 453601 agagaaggag ctatttacac gattcatgtc ggggagagac aaaaaatctt tcagagagtt 453661 gataattcaa tcctttaaaa ataaatttga tggggaatta ggtccatccg ttctagcagc 453721 cactttaagc tcgtgctttt catctcaatc gaaggatact tcgttagata ctgattctat 453781 atatgaagat gaagatgagg aagactatga tgactattca gaatatgctg aagatagcga 453841 agaggtttct gagtatgaag gaatagaggc agtcgaaaaa ccagagcatg atgaaaaaag 453901 caacgggata cgtgaaacat tacatttaag ttatgaccac gatcataaac gacagaacca 453961 ccctcaccat cactaccata gtaccagtac ccacagcgaa gatgaactga gtgaagaaga 454021 gtatatttcc gatatagaat taccgcatga tcctcataag cactttcacc gcgatgatga 454081 tatattagat ggggatgaag atgagccaga ggaagaggat gaaaatgaag gcgatgacga 454141 agaagatact tatgacagcg gtcttgatga aactgaccgt ttagaagaag gtcggaaatt 454201 gattcagata gccattacaa agttgcttca aagtcgaata atggcttctt atcatgagaa 454261 acaggcagat aataacagac taaaacttct acaagaacta gaagaagaaa aaagaaagaa 454321 aagagagaag gaagaaaaaa agcagaaaaa aagagaaaaa gagaaagaaa agaagaggct 454381 gcaacagtta gctaaagagg aagaaaaacg aaaaagggaa gaagagaaag aaaggctaaa 454441 gaaggaatta gaagagcgtg aaatgagaag acgagaggct caaaggaaaa aggttgaaga 454501 agccaaacgg aagaaagacg aggagagaaa gcgtagattg gaagagcagc agcggagaga 454561 agaaatgcaa gaaaaacaac ggaaacagaa agaggaacta aaacgcaaga gggaagaaga 454621 aaagaaacgt attagagaac agaaaaggct agaacaagaa aagctacaga aagaaaaaga 454681 agaagaagag agacaaagat taattgcaga ggatgcgcta agaaaacaga aattaaacga 454741 agaacaaaca tctgcgaaca tactttccgc caaacctttt actgagaatg gagttggcaa 454801 ccctgtttca tctcaatcac atcccaacat gactaactac caagaggata atagttgcag 454861 tatcaacgat gaaatactta aaatggttaa tagcgtggct gcatccaaac cagtttcacc 454921 cacaggcttt aacgttcatg atctacttct tccttcaact aacaaccaga tgcctgctat 454981 ggaacaatca cacttgccac agccaggtaa tcaaaacaac cattttggaa ctacaactat 455041 tccgaatgcg ttagacttgg ctacaaaatc ttctttacag actgaaaaca actatttaat 455101 gaactcacaa actctggaaa atacaagtct attgatgcat aataattcat cgccaactaa 455161 gctattgcca aatgactttg gtttatcatc ttggggtggt ctgacaaata caatgtccat 455221 aaatcctaca tgtaaaccac cggttattca aacttcagaa atggaatcac aagcccataa 455281 atctagtcct caagctacaa tgccatcttt tggactacct aatggtggta ctcaccgtaa 455341 atcgtttacc gacgagttga acactttaac tagcatgctt tcttcttccg ggttcgcaga 455401 tacatcactt tcatcatcag gattcccccc atcacagcgt tctgtgtgga atgatcaaaa 455461 aagctcattt tcgggaccgt cgactgcagg aaactttaac aacagcagta tacaaagcgg 455521 tatgctgctc gcacctacat taggaagcgt tgaatcgttt ccaaatcgaa cttctatctg 455581 ggacagcagc accactccga tgatgaataa atccgagctt tccggtcgca atataactag 455641 tactgcgcaa gatagccctg cgttcatggc atcaaatatc tggtctagta acagtcaata 455701 caattcacca tatttgacta gcaacgtcct tcaatcccct caaatttcga gtggagtgga 455761 tgaaagccac attctggata gcatctacaa tacttattta gctatttccc cacaagatag 455821 tttaaacccc tacattgcta tcgggacact attccaaaat ttagtaggac ttaacttgga 455881 ttactcgacg tttatcaaca aattgataag catgcaagga gcctacaatt gcgaattctt 455941 tactgataac aatggatcca ttacccacgt tcgatttgcg agacaaactc ccgctggcca 456001 ctcaaagggg ttgctgaatc aactctttag tggattgaac gatccaactg ctacaccatt 456061 tacgtcaagg cctcatacct ccacaagggc tagttttcca attgcctctt caactacgca 456121 aacgtcttaa atttgctccg gtacgcaggg ccaaaaatat ttacatacat acataattcg 456181 acgaaatttc agaagagaca ctaaacaatc gtacatctct ctactcgatg tgagccacgc 456241 gtcggttttt cttaccgtcg tggctttaga ggtgaggctg cgacacccca tacatcttac 456301 ccggcattta atttccattt ttcgcaggaa tgtgaatatg ataatagact tcggtacact 456361 cttttttagg tataacatat atcaattgtt caacaacaat tattcaaagc gcaactctcc 456421 aaaggtagtt attctgataa tttgaaccaa aagtccccag attaagtctt aattaaactg 456481 cccttgcata ccgctgtaaa cgatttgtgt gcagacatca attgctgaaa cgttctgctt 456541 tggttgtgct tttgatcccg tactatgtct gaaaaggccg ttagaaggaa acttgttatt 456601 attggtgatg gtgcttgtgg caagacctct ttactatatg tatttacatt aggaaaattc 456661 cctgaacaat atcatccgac agtgttcgag aattatgtca ctgattgcag agttgacgga 456721 ataaaagtgt ccttaacgct ctgggataca gcgggacaag aggaatatga acgtttacgt 456781 ccattctcat attcaaaagc agatataata ttaattgggt ttgctgtaga caattttgaa 456841 tcactaatta acgcaaggac gaaatgggcg gatgaggcat tacgatattg tcctgacgca 456901 ccaatcgttc ttgtaggctt gaaaaaagat ttgaggcaag aagcccattt taaagagaat 456961 gctaccgatg aaatggttcc cattgaagat gcaaaacaag ttgcaagggc cattggggcc 457021 aagaaataca tggaatgtag tgcactgact ggtgagggtg tggatgatgt ctttgaagta 457081 gctacaagaa ccagtttgct tatgaagaag gaaccagggg ctaactgttg cataatttta 457141 taaaaaaaac ttacactgaa atgatacatt atctttttag caagggaggg aaaaacaata 457201 ccgtattata attttaatca aatttcatag atataatgga ataagttaaa aaggcttatc 457261 gatagtgcat gtataaaaca caaacccatt cgatatgttt gttcgttaat gtcctacaga 457321 ttcttattcg agagccttta ccagaagcaa aatttccgac ggatataaga aaatggcaca 457381 tcaaaccata gctcaaggta ctgcgccgat gagctaaacg gaactgccta gtttgattat 457441 ttttcgttta tatacttatt tacttattta cgctatttgt attcgaattc cttacgaggc 457501 gatgagtgaa agacgcgcca gtaggacgcg tctttttttt ttcagtataa tgtaaacata 457561 ttattgaatt gccgaaggag acaaaaagaa aagaaaagag gagatcatct ttcatataat 457621 ccaaccacgt cgtagagcaa accacgacaa ttttaacttt ctgtttcagt taaaggagtt 457681 tataacgacc agcacggcta accatgtcaa ctgaaccggt aagcgcctct gataaatatc 457741 agaaaatttc tcaactggaa catatcttaa aaagaccaga cacttatatc ggttctgttg 457801 aaactcaaga gcagctgcaa tggatatacg atgaagagac cgattgcatg attgaaaaaa 457861 atgtcacaat tgtaccaggg ttgttcaaaa tctttgatga aatcttagtc aatgcggcag 457921 ataataaagt tcgtgatcca tcgatgaaac gaatcgatgt aaacatacat gctgaggaac 457981 atactataga agtgaaaaat gatggaaaag gtattcccat agagattcat aacaaggaga 458041 atatttatat tcctgaaatg atatttggtc atttgttgac atcatccaat tatgatgatg 458101 atgagaagaa agtcactggt ggtagaaacg gttatggtgc taagctttgt aatatatttt 458161 ccactgaatt catattagaa actgcagatc taaatgttgg ccagaaatat gttcaaaaat 458221 gggaaaataa catgagcatt tgccaccccc caaaaataac atcttacaag aagggtccat 458281 catatacaaa ggtgacattt aagccggatt taaccagatt cggaatgaaa gagctagata 458341 atgatatctt aggagtgatg cgaagaagag tttatgatat caatggttct gttcgtgaca 458401 ttaatgtcta tctgaatggc aagtccttaa agataagaaa tttcaaaaat tatgttgaac 458461 tctacttgaa atcactcgaa aaaaaaagac aactagataa cggtgaggac ggtgccgcta 458521 agtctgatat cccgactatt ctttatgaga gaataaacaa cagatgggaa gttgcttttg 458581 cggtttctga tatctctttt caacaaattt cttttgtgaa ttccattgca actaccatgg 458641 gtggtaccca tgtcaattac ataacagacc aaattgtaaa aaaaatttca gaaattttga 458701 agaaaaagaa gaaaaaaagt gtgaagtctt ttcagattaa aaataatatg ttcattttca 458761 ttaattgttt gattgagaat cctgcattta cctcacaaac aaaagagcaa ctgacaacaa 458821 gagtcaaaga ttttgggtcc cgttgtgaga ttcctcttga atatattaat aagattatga 458881 aaactgattt ggctacaaga atgtttgaaa ttgccgacgc aaatgaagaa aatgcgctaa 458941 agaagtctga tggtacaagg aaaagcagaa ttactaatta ccctaaactg gaagatgcca 459001 acaaagccgg tacaaaagaa ggctataaat gtactttagt tctgacagaa ggggattccg 459061 ccttgtcatt agctgttgca ggtttagctg ttgttggtag agattattat ggttgttatc 459121 cacttcgtgg taaaatgctg aatgttagag aagctagtgc tgatcagata ctaaaaaacg 459181 cggaaattca agccattaaa aaaattatgg ggttacaaca tcgcaagaaa tatgaagata 459241 caaaatcttt aagatatggg catcttatga tcatgaccga tcaagatcat gatggttcgc 459301 atattaaagg tttaattata aactttttag aaagctcatt tcctggtctt ttggatatcc 459361 aaggtttctt acttgaattc ataactccga tcatcaaagt ttccatcact aaaccaacaa 459421 aaaacactat tgcattctac aatatgccgg actatgaaaa atggagagag gaagaatcgc 459481 acaaatttac ttggaagcag aagtattata aaggattagg gacttctcta gcacaagaag 459541 tccgagaata tttttcgaac ttggacagac atttgaaaat attccattct ttgcagggta 459601 atgataaaga ttacattgat ttagctttct ccaagaaaaa ggcagatgac cgtaaagaat 459661 ggctgagaca atacgaacct ggtactgttt tagaccctac tttaaaagag attccaatta 459721 gcgacttcat taataaggaa ttaatccttt tttctttggc cgataatata cggtcgattc 459781 ccaatgtttt agatggattt aaacctggcc aaagaaaagt tctttatggt tgtttcaaaa 459841 aaaatttaaa gtcggaactg aaagtagctc aacttgcacc atacgtgagc gaatgtacgg 459901 catatcacca tggtgagcag tcattggcac aaactattat tgggctagcc caaaactttg 459961 ttgggtccaa caatatttac ttgctattac ctaacggtgc tttcggtaca agagccactg 460021 gtggtaaaga tgcagcggca gcgagatata tctacacaga attgaacaaa ttaactcgta 460081 agatatttca ccctgctgat gatccattat acaaatatat acaagaagat gagaaaacag 460141 tggagccaga gtggtattta ccaattcttc ctatgattct tgttaacggt gctgagggta 460201 ttggcactgg ctggagtact tacattcctc cattcaaccc attggaaatt ataaagaata 460261 taagacattt aatgaacgac gaggagcttg agcaaatgca tccgtggttt aggggatgga 460321 ccggtactat tgaagaaatt gagcctctgc gttacagaat gtacggtagg attgaacaaa 460381 ttggagataa cgtcttagaa ataactgagt tgccagccag aacttggaca tcgactataa 460441 aggagtactt acttttaggt ttaagcggta acgataaaat aaaaccctgg atcaaagata 460501 tggaggagca gcacgatgat aacatcaaat tcataatcac gctatcacct gaggaaatgg 460561 ctaaaacaag gaaaataggt ttttatgaaa gatttaaact aatttcgcct ataagtttga 460621 tgaatatggt cgcatttgat cctcacggga aaatcaagaa gtacaattcc gtgaatgaaa 460681 tattaagcga attttactac gtcagactag aatactatca aaaaagaaaa gaccatatga 460741 gcgaaaggtt acagtgggag gtagagaaat actctttcca agtaaaattt attaaaatga 460801 ttattgaaaa ggagttaaca gtcaccaata agcctaggaa cgctattatc caagaacttg 460861 agaatttagg gttccccaga tttaataagg aaggtaaacc atattatgga agtcctaacg 460921 atgagatagc tgaacaaatt aacgacgtaa aaggcgcaac ttctgatgaa gaagatgaag 460981 aaagttcaca cgaagatact gaaaatgtta taaatggtcc tgaagaacta tatggcacat 461041 atgaatattt attaggaatg agaatatggt cattgaccaa ggaaagatat caaaagctgt 461101 tgaaacaaaa acaagaaaag gagacagagt tggaaaactt gttaaaactt tccgcgaaag 461161 atatatggaa cactgacttg aaggcttttg aggtgggata tcaagaattt ttgcaacgag 461221 atgcagaagc tcgcggtggt aatgttccca ataaagggag caaaacgaaa ggtaaaggaa 461281 aaagaaagct tgttgacgac gaagactacg acccatcaaa aaaaaacaag aaaagtactg 461341 ctagaaaggg caaaaaaatt aagttagagg ataagaattt tgaaaggatt ttgttagaac 461401 aaaaactagt aaccaaaagc aaggcgccta caaagattaa aaaagagaaa acgccttctg 461461 tttcagaaac aaaaacagaa gaagaagaga atgctccttc ttccacgagt tcttcttcta 461521 ttttcgacat aaagaaagaa gataaagatg agggcgaact gagtaagatt tcgaacaagt 461581 ttaaaaaaat tagcacgatt tttgacaaaa tgggttctac ttccgctaca tcgaaggaaa 461641 atacaccaga acaggacgat gtagccacta aaaaaaatca aacaaccgct aaaaaaacag 461701 ctgtaaaacc taaattggcc aagaagccag tcaggaaaca acaaaaagtt gtggaactat 461761 ctggtgaaag cgacctagaa attttagatt catacactga tcgggaagat agcaataaag 461821 atgaagatga tgctatacca caacgatcaa ggagacaaag atcgtcgaga gctgcgtcgg 461881 ttcctaagaa atcttacgtt gaaactttag aattatctga cgacagtttc atcgaagatg 461941 atgaagagga aaaccaagga tcagatgttt cgttcaatga agaggattga ataatattta 462001 tccagagaaa gcgccattct ttttatatgt ttatatcaga aacaaataga agtcgatcgt 462061 aatgactaga ttatataatc agaaatagcc tttggtgatc acttccattt tagtcagcat 462121 aatagaaagt ttaattacgc gcttttttac attccgacaa agatctgccc gagaaaattc 462181 ttcgagaaga caacaacaac aaaaaaaata aagcctgggc gaaaaacatc gtgcgtttac 462241 ataatatctt gaaaagcaaa cagatatata aaccgctatt gaaattacct ttttaagtat 462301 tcgcctagaa gccttgtttc aagtagcatc aacaacaggt gttaggttaa actgctttga 462361 ctttttgttc tttaacgaat atcattaaaa aaaaaggaca tctataaaga atgtctccaa 462421 actcgtcgaa aactcgaacg gaccagataa gctccatgcc tggtattaat gaagccacga 462481 aggtggaaag taagaatgtt gtgaaggatg ctgttccaat aaaatctgaa gttgaaacca 462541 atggtacatc aatagtaaga gaaaaacaag atccatcgta cgttggttgg aaacaagttg 462601 gtggttggga ggaaaaggac gagttaactt ccgaagacct tttagtggac gtaaacaagg 462661 acactttttt ggggaacctt ttaccagata aattctatgg tgattggtat catgaagtcg 462721 ctattctcat catcgctggt ttatgttcct ttgtgctggg ctattttaaa ttctctctcg 462781 cgtccgtcct tatcgtgatg ctaaccacag gaatgttata tagaacttcg tccaaaaaat 462841 atagggaatc gttaagggat ttagcccaga aagaacaaac tgtagagaaa attactagtg 462901 attatgaatc tgtcgaatgg ttaaacacct ttttagataa atactggccc attatcgaac 462961 cttctgtctc ccaacaaatt gtcgatggta caaatactgc attatctgaa aatgtggcaa 463021 ttccaaagtt tataaaagcc atctggctgg atcaatttac gttaggtgtg aagcctccaa 463081 gaattgatgc cataaagaca ttccaaaata caaaatctga tgtcgtagtc atggacgtat 463141 gtctatcatt cactccacac gacatgtctg atcttgatgc aaaacaatgc aggaattacg 463201 taaattccaa tgtcgtatta aaggcaaaga tattcggaat ggacatacct gtttcagttg 463261 ctgatatttt ttttcaagtt tttgttagat ttcgtttcca attgatgaca actttgcctc 463321 ttgttgaaac tataaatatt cagttattgg aagttcctga agttgatttt attagtcgtt 463381 tattgggtaa ctccgtcttt aattgggaaa tcctggctat tccaggctta atgagattga 463441 ttcaaaaaat ggcatttaaa tacttgagcc ctgttttact cccacctttc tctttgcaac 463501 ttaatatacc acaacttctt tccaagactg gcttacctat aggtgttttg gaaatcaaag 463561 tcaaaaatgc ccatggatta agaaaacttg tgggcatgat caagaaaaca gttgacccat 463621 acttgacatt tgagctctct ggtaaaatag tcggtaaaac taaggttttt aaaaattctg 463681 ctaatcctgt ttggaatgaa tccatttaca ttctgttgca atcttttact gatccactta 463741 caatagccgt atatgacaaa cgcgaaacct taagcgacaa aaaaatgggt acagtaattt 463801 tcaacttgaa taagttacat gcaaatcact atcacaaaaa tgaaaaggta catttcctaa 463861 gaaattctaa acctgtcggt gagttgacat ttgatttgcg atttttcccc actattgaac 463921 caaaaaaatt actgaacggt gatgaggagc ctttaccgga tatgaataca ggtatcacca 463981 aaattactat tcgcgaactc aagggactgg atgaactaag tgacaaaaaa ttcgtctttg 464041 cagagttgta tgtcaatgca gaattggtga tgaccacaaa gaaagagaaa agaactgccc 464101 atttgaaatg gaactcagat tattattctg tggtaacaga ccgtagaaag actatctgta 464161 gatttgtttt gaaggatcag agtggtaaag taatttcatc ttcggtacaa ccattaaatc 464221 atttgataga tagaacagaa gtcaataaag aatggattcc tttaaggaat ggaaagggag 464281 aattaaaagt caccacttac tggaggccgg tagatatcga cctcggattg aaaagtgtag 464341 gatatactac tcctatcggt atgttgagag tgtttatcaa taaggctgaa aacttgagaa 464401 atccagatag cttaggaaag ataagtccat acgccaaagt atccgtcaat ggtgtggcaa 464461 gaggtaggac aaatgaaaga atagagacat tgaatcctat ctggaaccaa tcaatttatg 464521 tgtctgtcac atctccctta caaaaagtct caattgactg tttcggtata gatacaaatg 464581 gcgatgatca taatctcggg agccttaata ttcaaactca gaatatatat cataaagaca 464641 atgacgataa atataccatt tttattgaca acgctccaag aactggcaac ttaattggaa 464701 agaagggtgt aaaggggacc gttacgtatt atttatcatt ttatccagtt gttcctgttt 464761 taagcttgga agaggcgaag gaagttgacg agattaatga gaaaaaagat aagctagaaa 464821 agcagaaaag tacactggat gacaaaaaca tctcaaagga ggagaaagaa agaattaaaa 464881 aggaagagtt caggctcacc gaaaaatatg acatgtatag ttacaaaatg aagcttgacc 464941 tcgatgaatt gctgcaatac aatgctggtg tactaggtgt tactgtatta ggcggggaac 465001 taccccagcc tgggctctat gttcaaacat tttttgattc ctgtggttac gcagcgataa 465061 ctagtgcaaa aaatgctatt aggaccatta aaacaggctg gtcgggcgat ttcatgataa 465121 aagagctgga atggtccgtg actacattta gggtaacaaa gactaaagac gcgaataagg 465181 cggaaaattt tatttgcgaa gtcaacattc caacaattga attggtgagg aactgttatt 465241 acaaaccttc cgtattaaat ctaataggga aaaagagtgc caaactatta gttcaagtgt 465301 catggttccc cgtaactgcc acggaattgc ctcaatcaga cttgataact aactctggtg 465361 atttgaaaat caccgctaaa agtgctgaaa atctaattgg tgttaataag aatggttatt 465421 ccgatccata tgtcgaattc tttttgaatg aaaagagcac atcacccttc tttaaaaccg 465481 cagttcaaaa aaagacacta aatcctacct ggaacgaaag caaaactatc gaagtttcaa 465541 atcgtgtcaa tgactacttg acaattaacg tgaaagacta cgaatccact aactccaata 465601 ggagtattgg aaaagccgtt gttccattat ctactattga tccagagagc gataccacct 465661 ttaatatacc gttagtggga ccaaagggag aagatggcgg tgtgctacat cttgaatttg 465721 agtttgaacc ccgctatact accaatgtag tcaaacgtga agccgggctt ggaaattttg 465781 ccacgaaagg attaggtaca ggcatcaaag ctggttctac agttttcgcc ttaggaacca 465841 atgttgtaag caccggatta ggaacaattg ataaagtaaa ggccggagtc tttggtggca 465901 agaagtctac aaccactggg gacaaaaaat ccgaagagaa gcaataattc tatcgatggt 465961 aaagagtatg tgtcacgaaa tcatcttgat gccgcaatgt acgagcaaaa aaagaaaaga 466021 gaaatcaatc ttaacaactc aaccatgccg agtgctacta tagtactttt ctttattact 466081 acgtatgtaa attgtaacaa atgtgtactt ttatgtgtgt tcttaaatgg gaaactactt 466141 agcgttttgt tcatttccag tgttaagtag gaagaatgac tgagcgaaaa aaaccgtaga 466201 agtagaactt aaaataagaa cggaggctaa accaccaaaa cagctcatca acagttaaaa 466261 caccaccaat atttccagaa aaaagaactg tagatatagt ctcattagta tttagaagaa 466321 agaggatttt gcaatggcag gggatagtat aagcgctgac ggcactggcg tccatccagt 466381 tgaactgtcg gtgtattcag tattgtccac cgatttagac ggactgtatc aatcgatcaa 466441 tgaattacgc gagtcgcaag cactactcat ccttatgctt cggaaggttc gcgataaact 466501 tcgaagagaa ggtcaagtcc tttatgaccc agaaccattc aaaccaacca tggataaact 466561 ggctgactta tctgcccgtg tgcgcattct ctcacaaaga tacgaggagc ttcaggggaa 466621 tgctagagcc ctcaacaact aagtaaacat acacatgtat agcataatct tcgattcctt 466681 ttacccattc gtagatggca tcgacagtgt acttataata ctaccgtgag aaacgatatt 466741 aagaacaaga cgaaaaatgg tggaaaatct ggaaagcaag aacgtagcac gctagagtta 466801 ttctagcttg tcagctcgac tgtttaatta ttattgttat tatattaaca ttaacgtaat 466861 aaccattgaa ctacattaaa gaaataactg tctcgcttat atctggtcta ttttttgttt 466921 tttgcctttc cttttaaatt ctttataacc ttgaaaacaa aaaatcacat tggtaaatta 466981 caatcattta ttaccaaatt tgtccattaa ctattttagc gtgactgact gataaagact 467041 gtttcactct ctttatttat tcataacaaa aattcagata ttttgaacta taaagtacta 467101 aaggcagaaa aattaatagc aaattaagcg atggcaatca agtcattgga atcgttcctt 467161 ttcgaaagag gtctagtagg atcctatgcc attgaggctc tgaataattg taccctggat 467221 atagacgtca accattatgt ttccagattg ttgaccaata aaagagaaca gtatttggat 467281 gccattggtg gtttccctac cagtttaaaa atgtatttgg aaagcgactt aaagatattc 467341 aaggatttca atattacccc tatttttgtc tttaatggtg gtttgactta caaccaatta 467401 gaggcatcgg gccattttac tgcagcatct gcttctgcgt cgatttcgtc aaccactact 467461 tccagcagcg gtaccaatgc cacaacaaga tccaacacgg aatccgttct tttgcagaga 467521 agtagaggct ggacacaatg gaacaacttg attagttcga atcagaattc ctatattgac 467581 cagcctattc aaccccaaga gccattcaga cataacacca caattgactc caaagcttac 467641 caaaacgatt tgatcgctta ttttattgag catgggtata tgtaccaagt ggctccttac 467701 tcctcttggt ttcaactagc atatttattg aatagcgctt atattgatgc gatctacggc 467761 ccaactgatt gtttgatgct agattgtgtt gataggttca ttttgggtat ggaatttcca 467821 aataaagaat ttcgattcat tgacaggtca agagtgatga aggatttagg ttgtacccat 467881 gaagagttta tcgatattgc tatggctgta ggtaatgatt tgcaaccaac aactttacca 467941 ccattgcaaa tttatccagt tcctcagctg tttgatattg ctctagaaat ggttttgaat 468001 acaggtacaa acttctatgc ctatcaacta tctacaacct tacaaaatga ctccaaagag 468061 aatattcaaa actaccaaag aggtatttct gcattaagat acatgccagt cttgaaagat 468121 acaggtaaag ttgaattatt tgttcaagag atcgttgttt cagaggagga cagtgaaaag 468181 aataacaagg atggaaaaaa gagtaatctt tcctcaccat cttctgcgtc atctagtgct 468241 tctcctgcta ccaccgtgac taagaacgct agtgaaaagt taacttatga aaaatccagc 468301 actaaagagg ttagaaaacc aagagatatt cctaatgatg ttcatgattt tatcggccaa 468361 atgttacctc atgaatacta tttctataga tccataggac tggttactgg aaaattattt 468421 gacgcaattg tcacaggagt ttatcctgaa gagcctccat tgggcggagg atcttctaca 468481 tcctacaaga aactggtttc caagtccgtt gaaatcttca agaataaaga aatcaattta 468541 ttaactcaac caattaacag atactatcag attaaacaaa ttaaacaagt caagtggtat 468601 gcggcaaatg agcctaccac tttgaccaac aggatgtcac cttctatgtt tgaaactatc 468661 aaccacttaa ttgttaaaac agaaacgtct gatgaaaagg aattttctat ctctgagttc 468721 attacaacaa taaatggttc tagcaatatg gcgaaagatt ttatatctga aaaagtcatt 468781 ttcccaaact ccgtaccaat cgaatccaaa ttaaactcac catttaattt attgtcgacc 468841 aatttcttaa gattactagt actattggag ttcttcactt ttgatttcaa ggaaaaactg 468901 ctagagccta cgagatgggg tgaggtattc ttaaaattaa atgagctcaa tattgacagt 468961 aagtatcacg aatcagttat tatctttttg gtatttttga aatgcgatgt cttaaaactt 469021 gacgaagaag ttcaaccacc ggctccctca gccctatctc aagccactct tcgttcatat 469081 cctgaagaat cattgtacgt cctattgatt acgcgtgtat taactttatt tcaagtggac 469141 caaaagccat caaattacca cggaccaatt gataagaaaa ctttgatctt tagagatcat 469201 ctttctttca taaaggaaaa tttaaatgaa ctttttgaag ccgttttgat ctcatcttta 469261 acttctggcg agtttaatag attatcactt gataactttg gttgggcaag aaagattgtt 469321 agatatttac cgttcaaatt agattcccca aatactataa tggctatgat gtgggagttt 469381 ttcttacaaa aatatcttca caatggtaat gccaagaatg atgcattgtc tttagttgct 469441 actgaattca acacttacaa atccacacca aatcttgatg aacagtttgt cgaatcccat 469501 agatttcttc ttgaaatttc aaaagtcatg caggagctaa atgctgcgaa attaatcgat 469561 gaaaacgtgt ttaaattatt cactaaagca gttgagttta ctacaacagc tctatctagc 469621 tgaagcgtga gaatgagtat gatggaaata gtggaactat ttaaaaagca cccaataaag 469681 aaagatagtt actgtaaaga ggtatattat cattattcag agggttcaag taccatcatc 469741 aagatttaac acaagcacag tgaatagcaa caattaaaga aaaaactaat caaaatcacg 469801 gtagaaatag gagaaaaaaa gtaaaacaga aactaagtca ctgtttcttt atatgacata 469861 ttctattata taaatatgta aagaacgctg aacagtaaaa attttatgaa attccggcag 469921 agaagaaaag gaaaaaataa gtatacacca caccgttact ggatagattg aagttcaaat 469981 caaaaaagtt tacaagtgaa ataacaaaca gtaaatatta cacattcatg tacataaaat 470041 taattatcgg tgtcaattga tttctgcttg taatgcttgc aattcgtgtc tcttattgtt 470101 caagtaattc tccaatactt caacctgctg ttcaatgtta tccaagtcat cagttatcga 470161 cctgatgtta atccgcttag aaagttttga gcctccttga gttttttcac tctttttgta 470221 gttcaaaagg ccttctaatt gttctctcat gttcgcaact tgatcatctg tcagagaagc 470281 atatttttgc tttatactgt cttcatttga aagcacgtta ctgccactgc tatcggaact 470341 cgagttctgc ccattgtcac gcagattgtc cacttcgtta gcttcttctt ttctctttgt 470401 aggaggttga gaggaccgta aatcatagct cagttgtttt ttattgcaca cctccgccag 470461 agaatttggt aaacttgctg gaatttcagc acccaaatca tttctttgtc ttaaacagtg 470521 aataaaataa aaagtaggat ctctatcaat tgatggcaaa ttttgtgggt taattaaact 470581 ccaaacctta tttaaatctg tcttactgat gttaaaaaat tttgtggaaa gttttgttga 470641 cagttcgttg aatgtaatag taccatcggt tagttttgca cagctattat aaattttttc 470701 atattgattc aaatcatctg gagacatgta ccaatctact ttgatttcct tctttggagg 470761 caagtctgcg ttttctattt gcttgcgctt ctttctttct ttgattagat tcaccttact 470821 ccctggaatc aaccaatcag gcaattcatc tggaacagag ctaatgtttt tattaaccat 470881 atcaaatatt aatctcatgc aaattacaaa ttcctcaaag tctaaattgt cgtcgtcatc 470941 aatatcagct aaaaaccaaa tcttgtttag aaccgatgaa tctaatttgg aattataaag 471001 aattggtaaa acctggtcat ggtttacctt attctctatt ggtttcaaac ccgagaagat 471061 ttgccagtat ttttttattt caaattgttc caacttgggc atttttcaga gatccctgtt 471121 atctttaccg gcctttccaa tacccactaa ctctatggtt atattacaat cgtctgatta 471181 taacaggcaa ttaaccttgt gtttctgacg ttcttttcat tcattcttga tatgttaaat 471241 cataggggtc ctacacgatc gtcaaatatg atatttaaaa agtaataaat aaaaatgcag 471301 cttttttatt agcgatggga aatattgaat atttgaaggg gcaaataacg tttaattcaa 471361 tcgaatgacg gtctaaatgc tgctgaaaaa ttgcgagacg gacaagcagc gagatatacg 471421 gtatgcgtgt ttgttcaagg aacttgatgt taagggaaat ggtcaagtta ctctagataa 471481 tctgataagt gcttttgaga agaacgacca tccgctcaag ggaaatgatg aggcaatcaa 471541 aatgctgttt actgcaatgg atgttaacaa ggactctgta gttgatttaa gcgatttcaa 471601 gaagtatgct tccaatgccg aatctcaaat ttggaacggc ttccagagga tagatttaga 471661 tcatgacggt aagattggca ttaacgaaat aaataggtat ttgtcagacc tcgacaacca 471721 gagcatatgt aataatgaac ttaatcatga actttcaaat gaaaagatga acaaattctc 471781 gaggtttttt gaatgggcgt ttccaaagag aaaagccaac attgcgctac gaggccaggc 471841 tagccacaaa aagaatactg ataatgatcg gtcaaagaaa accaccgact cagatttata 471901 cgttacatat gatcaatgga gagacttttt gctgctggta ccgagaaagc agggttcgag 471961 acttcatact gcttattcct atttttacct attcaacgaa gatgtcgatc tgtcctcaga 472021 gggagatgtt actctcataa acgatttcat tcgcgggttc gggtttttta ttgctggtgg 472081 tatttcaggt gttatttcaa ggacttgtac cgcgccattt gatagactga aagtgtttct 472141 catcgcaaga acggatctat cctcgatctt gttaaattca aaaacagatc tccttgctaa 472201 aaaccccaat gctgacataa acaagatatc atctccatta gcaaaggctg tcaaaagctt 472261 atataggcaa ggcgggataa aggcttttta tgttgggaac ggtttaaacg tcatcaaagt 472321 ttttccagaa agttcgataa agtttggttc tttcgaggtc accaagaaaa taatgaccaa 472381 attagaaggc tgccgcgaca caaaagatct ttcaaagttc tctacttaca ttgctggtgg 472441 tttagctggt atggcagctc agttttccgt ttatcctata gatactttga aattcagggt 472501 gcagtgcgct cctttggaca caaagttgaa ggggaataat ttgctctttc agactgcaaa 472561 agatatgttt cgagaggggg ggggtcagat tattttacag aggtgtcaca gtcggtatag 472621 tgggcatatt tccctatgct gcattagatt tggggacttt ttctgcctta aaaaaatggt 472681 atattgccaa acaggcaaag accctgaacc taccacaaga tcaggtcact ctaagcaacc 472741 tggttgtact tccaatgggt gcattcagtg gaactgtagg agcttctgtt gtttatccaa 472801 tcaatctttt aagaacaaga ctacaagccc aaggaacata tgcacatcct tatgtgtata 472861 acggctttaa agatgttttg ttaaagacgc tagaaaggga aggttatcaa ggtctattta 472921 aaggtctagt accaacttta gcaaaagtat gtccagcagt ttccatcagc tatttatgtt 472981 acgaaaatct gaaaaaattc atgaatctgg agtagtgata ataacatatg catatgtatc 473041 aactagtgaa ttctatttaa ttataaaccg ctgctgcggt ttgtgggcgt actgtcagcc 473101 aagctttcgt tataatatat attcttttca acatgtacat agctagaact ctagaaagca 473161 cagattaata ccgattctaa tacagatttt aatgacctca atagttaatt gatatttgat 473221 aaaatattat aaaaatcgtc tataacagaa cgcgaaaaga aaagacgcgt ctctcttaat 473281 aatcattatg cgataaaatg tttcaccaca tcgaaaactt attaattgag acagaaaaaa 473341 ggtgtaagca aaaggaacag aggtatatcc ctgtgaaata tttatttagc atgacacaaa 473401 ttcatcagat aaacgatata gatgttcatc gaattacatc tggacaagtt atcaccgact 473461 taacaactgc agtgaaagaa ctcgttgata atagtataga tgcgaacgca aaccagatcg 473521 aaataatctt taaagattat ggtcttgaat ctatcgaatg ttctgataat ggtgatggca 473581 tagacccttc aaattatgag ttcttagctt taaaacatta cacatcaaaa attgcgaaat 473641 ttcaagatgt tgctaaagta cagacgttag ggtttagagg ggaggcccta tcttctttat 473701 gtggcatagc taaactaagt gtgataacaa caacttcacc accaaaagcg gataagttgg 473761 agtatgatat ggtcggtcac attacttcaa agacaacgac atcaagaaat aaagggacga 473821 ccgtgttagt ttcgcagtta tttcataact tgcccgttag acagaaagaa tttagcaaaa 473881 cttttaagcg ccagtttacc aaatgtctca cagttataca aggttatgca atcataaatg 473941 ctgccattaa attttcagtt tggaatatca caccaaaggg taaaaaaaat ctaattctat 474001 caacaatgag aaattcaagt atgagaaaga atatatcctc agtattcggt gcaggtggta 474061 tgcgtgggct tgaagaggtt gatttagtgc ttgatttaaa tcccttcaag aatagaatgc 474121 ttgggaaata caccgatgat cctgatttct tagacctcga ttataaaatt cgagtgaagg 474181 gctatatatc acagaattcg tttggttgtg gtagaaatag taaggatagg caattcattt 474241 atgtgaataa aaggccagtg gaatactcta cgcttttaaa atgctgcaat gaggtttaca 474301 aaacgttcaa taatgttcaa tttccggctg tatttctcaa tcttgaatta cccatgagct 474361 taattgatgt aaacgtcact ccagacaaaa gagtgatact gttgcacaac gaacgggccg 474421 tcattgatat tttcaaaaca actctcagtg attattacaa tagacaagaa ttagctcttc 474481 ccaaaagaat gtgctcacaa tcagaacaac aagctcagaa aagacttaaa acggaagtct 474541 ttgatgatag aagcacaaca cacgaatccg ataatgaaaa ctatcatacc gccagaagcg 474601 aaagtaatca atccaatcat gcacatttta atagtactac tggcgtaata gacaaaagta 474661 atggtacaga actaacttct gtgatggacg gtaattatac taatgtcact gatgtcatcg 474721 gttcggagtg tgaagtttcg gttgattcat cagttgtatt ggatgagggc aactcaagta 474781 caccgactaa gaagctgcca agtatcaaaa cagattctca aaacctaagt gatctgaacc 474841 tgaataattt ttccaatcct gaatttcaaa atataactag tccagataaa gcacgtagct 474901 tggaaaaagt tgttgaagaa ccagtttatt ttgatattga tggtgaaaag ttccaagaaa 474961 aagcggttct atcacaagca gatggtttag tttttgtaga taatgaatgt catgagcata 475021 caaatgactg ctgtcatcaa gaaagaagag gaagtactga cacagaacaa gatgatgaag 475081 ctgactctat atacgcagag attgagccag ttgaaatcaa tgtgagaact cctctaaaga 475141 actcacgtaa atcgatttcc aaagataatt ataggtcatt gagtgatgga ttgacgcatc 475201 gcaaattcga agatgagata ttggagtaca atttaagcac aaaaaatttt aaagaaataa 475261 gtaaaaatgg caaacaaatg agtagcatca taagtaaaag aaaatcagaa gctcaagaaa 475321 acattatcaa aaataaggac gaactagagg atttcgaaca aggagaaaag tatctgacgt 475381 taacagtttc aaaaaatgat tttaaaaaaa tggaggttgt tggacaattt aatttaggat 475441 ttatcatagt gaccagaaaa gttgataaca aatatgatct gtttattgtc gatcagcatg 475501 caagtgatga aaagtataat ttcgaaacac tgcaggccgt gacagttttt aaatcgcaga 475561 aattgataat acctcagccg gtagaattaa gtgtcattga tgaacttgtg gtgctggaca 475621 atttaccagt ttttgaaaag aatggattca aattgaaaat tgacgaagaa gaagagtttg 475681 gctccagagt taagctgtta agcttaccta cttccaaaca aacccttttt gatttgggtg 475741 attttaatga actgatacat ttgatcaaag aagacggtgg gttacgaaga gacaacatca 475801 gatgttccaa gattcgttct atgtttgcta tgagagcatg tagaagtagt ataatgatag 475861 gtaaaccgct gaataagaag actatgacca gagtcgttca taatctcagt gaacttgata 475921 agccttggaa ttgtccccat ggacgtccaa caatgagaca tttaatggaa ttacgtgatt 475981 ggagctcatt ttcgaaggat tacgaaatat gatctagctt tgatattcat tcattatata 476041 attaacaaat acattatata cagggagtga caacacaaaa tatactcgtg cattgaagat 476101 gcttgatgga tatatgtatt acgacataaa gcttagccat taagaatatg aacgtggctt 476161 taatttgttt atatgtggag agtataatca cttgccaaag atacaagacc aaagggacgg 476221 attatgttgt acttttgctt gagaaaatgt gtgaattcca cgtctatcga ttttattaag 476281 cttccttgca gttttcgcgt tgtttcttgt atgctggccc ctaactggca gatgcaatgt 476341 atgtctcata ccgctataac tcccaatttt tctttttaga gctatattgt cttttacgat 476401 tgctctagcg tctccttcaa tcgtcattgt cgacagttca ctagctatac tcatgatttg 476461 gggttctgat agttggtgca tcctcatcca agggtagaac cctaacttcg agcatatctt 476521 ttcggctgtt gttttaccta tgccgtaaaa tttagaggcc agtgcgattt taatgacctc 476581 tttacctttg aaacctttac ccaagatgtg aacgaccatg gttttgatgg aagacccgac 476641 ttgatttgct cttgaatcgt ctcttctatt ttgaagtaac aacgtatcct agcctgatat 476701 atgaaggagt ttttttaacc ttaaagaaca aatatatttc atttctataa tgagcgccat 476761 gtcgtcaata gggatattgt atcttcagct gtcatgtaac atattaactt ccaggaatct 476821 taattgaatg attatgtagg gatgatcttg tagcgtaaat atagatacat agttagagct 476881 gttgcagcat atacatatac atatatatta tatatttttc ttttattttt ttcatgcggg 476941 gggatgcatt tcatgcagta ttctttctaa ttgctctaca tccaatcttt ggatgaacag 477001 gtttcgcagt aaacctaaca tggtgataaa actagctagt cccacaggga cgacacaaag 477061 aaccgtgatt ttatatagat ctatcgttcg cttagtggta aaattgaatg ctttttttgg 477121 atattttttg ggtcttttag ggctttgtga atgagagact gagggcctgt taacaggaaa 477181 caatccgcca tcactgttat cggagagact gtcgttggaa ggaacatcta ctgtactttc 477241 gtcggctacc acaacatgtg agtcttcatc agcgtcatct tcaccatcct catagtcttc 477301 tgtttcttct ggaacattag tatcctcttg tacttcgcct tcctggttcc tgatatacct 477361 cagatccgag gtaagataac tttgccaaat gtacactgct gttagtacac aactaatgag 477421 tatccatgta tgcaaaaaat agtcgagttc cggagacaaa gacgacaaaa gaaggagttc 477481 taaggtgaca atgatcaatg acatggaaaa cattcttaaa atggcggcca cagtagagta 477541 cttgacgatc catcggacca tcaaagagtc gagaatggca tacgagaggt ataaagacac 477601 caggcaccaa agtgagcaaa ggagatattc agacgctctt gctgtagtga gtgcggataa 477661 taggagtgaa tccttaccgt cgccattcac agccttttgc gaagctcctt caaatgatga 477721 gttattgtcg taagcgctat tgagtttttg ccagaaataa gtgaacgcat ctcttagtga 477781 ttgtggctcg taaagcgtta tgctggtgcg catggagact ctccaagcct tccgcagaga 477841 tgtgaagatg taagttaacg gcggtaaaag ggatatgtcc ctgcataagg ccatcagcat 477901 atgctgcttg gcagttaaat gattcaaaga cagcgttttc atagaactgt acgtcttttt 477961 aaaggtcgct cgctcatgct tggcatactt gtcctcatga gggcccatac cagtacttag 478021 tatccacgtc atctggtttt ttaaaaccct gaagaatcaa ataagattat ttgaccaaag 478081 gaagggaagg gaagagaaaa aaaacttaaa gaaaaaagaa atgagaaacc ctggtgtgtt 478141 cacgtagatg cacagacggt gggcaaccca aaacttagtc ttccgataaa cttttcaggt 478201 tcttgtacac gtggaaacgc ccgatatata tcacatgtag ctgtgtaata tgagaatgcc 478261 tttgtccatg tgataaaccg tgcaaaactt aacatgggag caggcacaag tgtgagtccc 478321 acgaacaaaa cgccgctcgg gtaataacgc ccaatgtaaa aacatcataa atcagcacgc 478381 aaacggtaaa gaacaaaaac atcttcaagg gaaaagtata cagatgtata gtctaagcta 478441 ttgtatttgt ataaatggtt cttattttag tttcgtttgc ccatgagcgt ttgatttgct 478501 caagaacaag gaacaaagac cagcgtgttg gggaaaagaa aaagaaaaca aaaaacaaaa 478561 gtagatcaca agttttccag agatgcagca atttcgtcca gttccttctt tgcgtcttcg 478621 tacttgacgg tcaattcctc gttctttctt tcccattctt ctctttgttc ttccaaggca 478681 gctactcttc tttccaattg atctgccttc aagtcggact ctctcaattt ctcagtggtt 478741 tcctttagct tggtgtcgct ttcctccaag tcttcttcca attgctggtt cttcttggag 478801 aaattgtcgt tgttggactg caagtggtga gagtcctcgg acaattgctt ggattcagcc 478861 aattctgctt ccaacttctc gatctcttcc tccaattggt ggttcttcac cgtcaaggac 478921 ttgatctgat tttctttttc aacgttatcc tgttctgttt gcttagagtc agaaagtccc 478981 gcttccagct tctcgatctc atcctccaat tgctggtttt tgacggttaa agacttgatc 479041 tgattctcct tttcgacgtt ctcttgctcc aagtccttgt tcttctcttt caactcctcg 479101 tacttctcct gccatgattc ggcttccaac ttcaagttgc ttagcttttc tctgattttg 479161 tccattgttg ccttttttgt gtgtatgggg tgtgagttct actatgtaga tttcttctac 479221 caacctaatc ttttacagta tcagaaggga aaaacgaacc ttcttcttgc caagtatgca 479281 gtatgtgatc tctaacactt ttccgtttct cgtagatcgt gctatggtgt gctgattttt 479341 tattttaatg gttacccgac ttctttaccc ggctctccgt cgggtaagat atatgtgcta 479401 gcgccacgcg atggctggtt tgtcttttta agttcttaat atttattttt atattttgat 479461 tttttttttt tttttttttt tccattagtg aatgacagca atgtattaag ctgctgccgc 479521 gcatacaaaa tgtactgcgt taaattagat tagcttaaat tagtgcttgg taaaggagga 479581 gtggtttcaa gtccggtgtg cgccccactt tattcgggta tcttctacgt ttttacatcc 479641 atgtttcagg tactgttgaa aatagttaag atcgttcgta tttcttaatt catgtatttt 479701 tccctgttcc taactcgcaa acatcagttt tcttgcagat acgtcttgaa atacaaccat 479761 acagacaatg gagacatacg agactagcat tgggactcag tcttatcccc cgactttgtt 479821 cccacctccc ctgggtaccg gtgggtttac cacttcaggt tatatacatg cgcttgtgga 479881 ttctacatcg aactcgaact cgaactcgaa cacaaattcg aacacaaatt cgaacacaaa 479941 ttcaaattca gataccaaga ttcctatagt gcaaatatcg gatgactctc atataacaca 480001 cgacagcttc aaaccatata tggagtacca cgatgcttcg cacttgagga accgtaacat 480061 aagcaaagcg gaccaggttg aaagcactga agtgatggaa cagtttacgc aatggtcgaa 480121 ttataagatg aggtctcgct ctcctaccat aaacgcaaag ccaattcgac acacttcaca 480181 acgaagaaca gactttacca gcaaaaatga actctccaag ttcagcaaga atcataattt 480241 catttttcac aaagggtttt tgaagaggca acactccata cgcagggaag acaggcaagc 480301 aaaggtacgg tcaagattca ggagcaagaa ggagctgaca tccgttttga actatataga 480361 actggaacaa atggatattg caaatgtcct ggcttcgcaa ccggtaaact tacacgctat 480421 cagaaatctc actagcaggg accctgcggt aactcctatc ccatttttaa gaagccagat 480481 gtatgcaacc agtagtcgtc caccgtatct aaggaaccgc tccataagta ggaaactacc 480541 caaatcacaa ccaggtagtc tcccgacgac tatgcctgcg acggcgacga aaacaattaa 480601 acagaattca acgaccccaa ccacaagatc tgtttataac aagaatgtgg ggcggtccaa 480661 tacttcccct agtgtgttgt accacccaaa aagaagagga aaattgaaca ccaaatcgca 480721 tgcaagaaag gagcaactgc tgttggaact gtggagagaa tacttaatgc tggttataac 480781 acagaggacg caactgcgcc tgactttgct ttgctctccg ggttcagcat cgaatgaaag 480841 ctctgtctgc tcttctaacg ccagcgactt agacatgtcc cttttatcta ctccttcaag 480901 tctcttccag atggcaggtg agaccaaaag caatcctata attatacccg acagtcaaga 480961 cgatagtata cttagtagcg acccctttta agtaggtaac cccccctgga ttgcatagcc 481021 attgcatagc cttagacatc aaactttatt taatcacatt atccttctat gtatcttttt 481081 cccccgctcg atttcttcta gaacattacg gaaaataaag gaaaaaaatg actggagcat 481141 cgaatctgta gactaaaaag gtaatgacgc gttcttcgtt cccacaagta tgtgaaatcg 481201 tttgaacgct tttatatact gataggaata gattataata gtattcaaca ttcatcaaac 481261 agtttatatc ggtaataaac caacctcacg atacagtgat tatttctcta aacaacacga 481321 gccgtactgt acctacgata aagtaaaaca catttttctt ttgctaccag tggacacaag 481381 ataacggaga atgcaacaaa acacgtcttt atatgactct ttgaacgtta ctgccgctgc 481441 atccacatct gagattaaga aagcttacag gaacgctgca ttaaaatatc atcctgataa 481501 aaacaatcat acagaagaat ccaagcgaaa gtttcaagag atatgccagg catacgaaat 481561 acttaaagac aatcgtttaa gagctttgta tgaccagtac ggtaccacag atgaagtcct 481621 gattcaagag cagcaggcgc aggcgcaacg ccaacaagcc gggccgttca gttcatcctc 481681 aaatttcgat acggaagcaa tgtcattccc ggatctatct ccaggtgatc ttttcgcgca 481741 gttttttaat agttctgcta ccccctcttc taatggctcc aaaagcagtt ttaattttag 481801 cttcaataat agctctacgc cgagcttctc ctttgttaat ggcagtggcg tgaacaatct 481861 gtactcctcg tcagcaaaat acaactccaa cgatgaggac catcatttgg atagaggccc 481921 tgatatcaaa cataatctaa agtgcacatt gaaggaactc tacatgggta agactgcaaa 481981 gttgggtttg aataggacaa ggatttgcag tgtttgtgat gggcacggtg gtctaaagaa 482041 atgcacttgt aaaacatgca aagggcaagg tattcaaacc caaactaggc gtatgggacc 482101 tctagtacaa agttggtctc aaacttgtgc agattgcggg ggtgccgggg tttttgtcaa 482161 aaataaagat atttgccaac agtgccaagg tcttggcttc attaaggaga ggaagattct 482221 acaagtcacc gttcaaccgg gatcgtgtca taaccaactt atagtactta cgggcgaagg 482281 tgacgaagtt attagtacta agggaggcgg tcacgaaaag gtaatacctg gtgacgtcgt 482341 tatcaccatt ttacgtttaa aagatccgaa tttccaggtt atcaactact ccaatttgat 482401 atgtaagaag tgcaaaatcg acttcatgac cagtttatgt ggaggcgtag tttatattga 482461 agggcaccct agcggtaagt tgatcaaact tgatattata cctggcgaga tactgaagcc 482521 tggttgtttc aagactgttg aggacatggg gatgcccaag tttatcaacg gtgttcggag 482581 cggtttcggt catctatatg tcaaattcga tgtgacgtat ccagagagac tggaacctga 482641 aaatgctaag aaaatacaaa atattctggc taatgataaa tacattaaag cagaacgttc 482701 caccatggaa accgcagatt cagactgcta ttgcgatttg gagaagtcat atgacagtgt 482761 ggaagagcat gtgttaagta gctttgaggc ccctaattta aacaatgaag ttattgaaga 482821 cgacgacctt ggtgatttga ttaatgaaag agattctcgg aaaaggaaca accgtcgatt 482881 cgacgaaagt aatattaata ataataatga aacgaaacga aataaatatt cttcaccggt 482941 aagcggtttt tatgaccatg atattaatgg atattgaagg ttatatagtc atgcagtaat 483001 gttatacatt ttctattttt attttttgta tcagtactct atctataagg acattccttt 483061 ttttaagcaa tgcggaaaga tacgctattc ttcctgtgga tggtttaccg cggtttgggt 483121 ggtaatatca ttgcagccct agtcctttag cagttttttt agcgtgtaat acattgttat 483181 tcatcttttt cttagtgcct gccaagagat cgtgggaggt tacttaacag aaaagcaaaa 483241 aaaaaaaccg attagaatgt gcatgccgtt gttacagaga agcaagggaa gttcaccact 483301 gatcatattt ctaagttcat caaaatatcg ttttggtttc agcagtaggg atctttaacc 483361 caagtgttca ttttctttcc tttttgcttt ttatttgaat gatctgaaca aaaggagaaa 483421 catatactgt actattgcgt gaaaacgaac agagcacaac cctcaagaaa aaagagaact 483481 accccttagt tccatctcat ttacttaagc aacacttcct aattattctc taatcctaat 483541 aaaaaaaaag aactgatgtc gcgggaggca tttgatgtac cgaatatagg tactaacaag 483601 tttttaaaag tcacacctaa tttatttacc ccagagcgat tgaatttatt tgatgatgtc 483661 gaactatatc ttacgttaat aaaagcatcc aaatgtgtcg agcagggaga aaggctgcac 483721 aatataagtt ggagaattct gaataaagct gttctaaagg agcataatat taatcgatct 483781 aaaaaaagag acggcgtgaa gaacatatat tatgtgttaa atccaaacaa caaacagcca 483841 ataaagccaa agcaggcagc agtaaagcag ccaccattac aaaaggccaa tttgcctccc 483901 acaacggcaa aacagaacgt tttaactcgg ccaatgacat caccagctat cgcacagggt 483961 gctcacgata gatccttgga taatcctaat tctacaaaca atgatgtgaa aaatgacgtt 484021 gctccaaaca gacaattctc caaatctact acgtcagggt tgttttcaaa ttttgcagac 484081 aaatatcaaa aaatgaaaaa tgtgaaccat gttgctaata aggaagaacc acaaactatt 484141 atcactggtt ttgatacaag cactgttata accaagaaac ctttacaatc aagacgctca 484201 agatcacctt tccagcatat aggagacatg aacatgaact gcattgataa tgagacttcc 484261 aagagtacca gtcctactct tgaaaatatg ggaagtagaa aatcctcttt tcctcagaag 484321 gaatctttat tcggaaggcc aaggtcttac aagaatgacc aaaatggtca actgtcactt 484381 tcgaaaacat cctctagaaa aggaaaaaac aagatatttt tcagcagtga agatgaagat 484441 tccgattggg acagcgtttc gaatgattca gaattctacg ctgatgaaga tgatgaagag 484501 tacgatgatt ataatgagga agaagcagat cagtactata gaagacaatg ggacaagctt 484561 ttatttgcca aaaatcaaca gaatcttgac tcaacgaaat catctgtttc atcagcgaac 484621 acaatcaact caaacacatc ccatgatccc gtacgaaaaa gtttactcag tggactattc 484681 cttagtgagg caaatagcaa cagtaataac cacaatactg cacatagtga atacgcttct 484741 aaacacgttt cgccgactcc tcagtcctct catagtaata tcggtcctca accgcagcaa 484801 aatccaccga gcgctaatgg tataaaacaa caaaaacctt ctttgaaaac aagcaacgtg 484861 acagctctag catcgctatc tcccccgcaa ccatccaaca atgagcggtt atcgatggat 484921 atacaaaagg acttcaaaac tgataatgag tccaatcatt tatatgaatc taatgctccg 484981 ctaactgctc aaactatact gcccaccgcc ttatctactc acatgttttt gccaaataac 485041 attcaccaac aacgaatggc gattgccact ggtagtaata cgcgacatcg tttttcgagg 485101 cggcagtcga tggatatccc atccaagaac aggaatactg ggtttttgaa gaccagaatg 485161 gagatctctg aggaagaaaa gatggtacgt acaatatcac ggcttgacaa tacgagtatt 485221 gcaaacagta atggaaatgg taatgatgac acctctaatc agagaacgga agcactgggg 485281 cgtaagacga gtaatggagg gcgaatatga ttactaagtt aaataaatca gatacagtat 485341 ttaaagttct ttcaaaaaaa gataatgtca tatattttac tatctacgca gtgaaagagt 485401 tccttctaat gacacactat tcacttcggg taacggatat tgtgtactga aaaatataaa 485461 aaattttatc ccggaaatgc gatgagatga aaatgcatga agtagcgtat atattgattg 485521 catgaggttg gacttgaaag ggcatatata ctcggtttta tcattgattc aagtgttccc 485581 ataaataata aaacagttaa atcgaaatgc taagaagaca agcccgtgaa aggagagaat 485641 atctatacag aaaagcgcaa gaattacaag attctcaact gcaacaaaaa cgtcaaataa 485701 ttaaacaagc gctagctcag gggaagccat tgccaaagga actagcagaa gatgagagtt 485761 tacaaaagga tttcagatat gaccaaagtt taaaggagag cgaagaagca gatgatctac 485821 aggttgatga tgaatatgct gccacaagtg gtataatgga tccaagaatc atcgtcacaa 485881 catctcgtga cccaagcact cgtctctcgc aatttgccaa agaaattaaa ctgctatttc 485941 caaatgctgt caggctgaac agaggtaatt atgtgatgcc aaatctagtg gatgcttgta 486001 aaaaatccgg tactacagat ttggtggtat tacatgaaca tagaggtgtt ccaacttctt 486061 tgaccatatc acattttcca catggaccca ctgcacagtt tagtttacac aatgttgtta 486121 tgagacatga tattataaat gctggtaacc aaagcgaagt gaatccacat ctaatatttg 486181 ataactttac taccgcttta gggaaaagag tagtctgtat tttaaagcac ttgttcaatg 486241 cggggcccaa aaaagattcc gaaagagtaa tcacttttgc gaataggggt gatttcatta 486301 gcgttagaca gcatgtatat gtgagaacaa gagagggagt agagattgcc gaagttggtc 486361 ctagatttga gatgaggttg tttgaactga ggttgggaac tttagaaaat aaggacgctg 486421 atgttgagtg gcagttgaga agattcataa ggactgccaa taaaaaagac tatttgtgaa 486481 tttttttata gatttgtaaa ggttaaaata gaaggccgat gaggccttat gtaagtctaa 486541 tatggtattc ttaaaaaaaa aaaaaaaaaa aaagcgtctt agagggaata taagagaaaa 486601 gaagagatag cataacacat gatttatttt tatttttgcg tttttttttt ttcttaattg 486661 tttatcaatg tatctgtgag agtatctaca taaaaaaaat aaccatatga agacataaat 486721 ttaaaagaac aaaacgaacg aagggaagag gtgcagaaag gaaatttatg tatcacaact 486781 attaaattca gttgaaaatc caccatttga aacttttttc ttaagcactt cactgacttt 486841 ttcaactctt aactcatgtt cggaggataa cgtattagaa gaagacacgt aagaaggatc 486901 tgttgataaa ggcatgggct tgcctattgc tgtatatgac gaagatgtcg ataaaggcgt 486961 ctgggttgct aattcgggat tacttgccaa gtttgcactt gaacgcaaag acgaacttaa 487021 cggaaaggaa ggatctagca tgtccatggt taaatcttct tcttcgctgt cacttgattc 487081 tatttggaac ttgggattct tgtgcatgtt tgcaacaggg tcaacgtttg ataaaatgga 487141 ttgtctttga aatagtatcg aagatgaccg gttttttggg gattttgcat tgttattagc 487201 attatttgaa tattgtctcg cagattgctg cggagataca taaggcgaag tagctggtaa 487261 ttctgtagtt ttgatgaagg ggttggaaaa tgtcgttgtt gctgacgatg aagaataggc 487321 ttgtggtggg gacctcttga ggatgaaagg gcatgagtac gcttgggatt tcataggtgg 487381 tctagatgta ggcgtattat tggcctgtgc aagtttttca tcattcaaca tatcgacgta 487441 agagtagaat cttagtattc tggagtttgg ttcgccattt gaagttgtgg tggtcatccc 487501 ggtgttattg atgttattca aggtgggacg tgtagccgca gaatgcgaat gagatctcga 487561 aagtttaaga tctggcgatg ctggcgaaga ttctgatgag ggaagagtgg cactattcgt 487621 tctagccaac agggccatgt ttaggctcac agcagaggaa ggtcttcttg aataaaccat 487681 atcgacatcg ctcaggtcag tgttctcatc gttcactatt gagcaactag catctaaagc 487741 tggagccacc gagttttcta acgtacgacg gcgatggtga tgattttgca tgttgcaaat 487801 ggggttcaag atgtactctt gatgtgctag cgagcttgtg gtggagttcg acgccgacct 487861 agacgttggt atgacgttat ctagcggaga ggaaacatta ttggagttct tcctcaacga 487921 tggagttcta acctcgctac cagagatagg tatcggagaa atggtctgca agttgtaaaa 487981 actattagat cttgagctat gagatgtgtt ggaggcggaa accggaggtt gaagaaataa 488041 atcgtttgaa cttgcctctt gcacggttct ttcgaagata aaagaagggt tgctgttgtt 488101 cgaatttgac ttgtacacgc acataccgtc ttttttggca gtttcctttg acagcactta 488161 gattctcctc aagctctttt taccgtacct gttcctattt gaaatattta gatctgtgaa 488221 aggattagtc ttttattcgt gataaaagcg aaaatctaat cccctgggcg ccgcggagtg 488281 ctcttcgccg agataaatat actaaaagag aggctttaat tagtacccga aatgacggtg 488341 aatagtggga tacttttata atggtgttat gttacatgat tgccgatgaa tgtgctgtta 488401 aaaagacgca gtttaacgtt tgcaccgaga tggctgtggt gcaagtgtcg aagtagcagg 488461 agcaggccgt attctctggc acacgcggtc gacacaagta agatggaggc aaccaggagg 488521 aacggtcaga ttgtgaagga cctgggtaga tactatccgt caatgtcaga atcagcactc 488581 cacgatcttt gccaggagta taaagaagtc actatcgcag actttaatga gagattcttg 488641 ggcaacccag ccacattaca ccatgaggat aatcctaatt tgttacttag tattaatggc 488701 aggattaaaa gcattaggtt ttcaggccag aagattgttt ttatagatct ttacaacggc 488761 agtagcggat tgaagaatga tacgcaactg cagttgatcg taaactacaa taaaattggt 488821 gggagtagtg aggataaggc gaatttctca gaatatatga actttttgaa gaaaggagat 488881 tatattaagg cgctcggtta tcccgggttt tcccaatcca gagtcaagat gctgtccttg 488941 atatgtaata agctacctat agtattgtct gtttcgcaac tgccgttacc ttccagactg 489001 aatgatgaaa ccaagatcaa atctaataga gttgttgact accaattaaa cggcactcag 489061 acactgctag taagggcgcg tatcatcaaa cttttgagga agtttctcga cgacagaaac 489121 ttcgttgagg ttgaaacgcc tatactgtca tcaaagtcca acggtgccat ggcgaagccc 489181 tttataacgt cgtccaagga cttcgaccat ttggagttgc gtattgcacc agaattatgg 489241 ctgaagaggc ttataattag tggtttacaa aaagtatacg aaataggaaa ggtctttcga 489301 aacgaaggca ttgattccac gcataatgct gagttttcca ctttagaatt ctatgaaact 489361 tacatgtcaa tggacgatat agtcacaagg actgaagatt tgttcaaatt tttgattact 489421 aacttgcaaa agttctttca agatacccgt ctgcctgtcc ctaagacgtt tagtgaatta 489481 catctggcac tatccgagaa taattggaag tttagaaaag tcgaattcct gcccactttg 489541 aacaaagagc ttggcattga tctaatgaac tctggattgg atatcaataa gccgagcgaa 489601 cttttgaagg ctttaccgaa agacattgcg aagaagtatt ttccttctgc agataacact 489661 gggcaattat cttcgctgca aatcctaaat aaactatcgg acgtgttcct cgagcagcgc 489721 cattgtcaat caaccttgcc tacggtaata taccatcaac ctgcaatatt atcgccctta 489781 gccaagacgg atccgcaaaa taagcaagtc acgaagagat tcgaagtctt catcaaaggt 489841 aaggaataca tcaatgctta cgaagaggaa aattgccccc aattacaact gcagaagttt 489901 ctacaacaaa agcagattaa cgaattgaca ggaaacaaaa ctgagacctt atcgcctgtt 489961 attgactacc agtatgttga gacgatgaaa tacggtatgc ctccagtagg tggctttggc 490021 cttggcatag atagattgtg catgctattt tgcgacaaga agaggataga agaggttctg 490081 ccctttggct gtgtggatga tgtaaacagg cagtaaattt tgcgacgcct gccaatgctt 490141 ttgtaaataa atcagacata tactgtaaat aattagaatg gcatttaatt tttttttttt 490201 ctctacacca ataaactacg ctacgcgaaa aatccaatat aaatattcag ttatagctaa 490261 tgagagtgtc gaaaaacctt gaaaacaact actgcacacc aaattgatac gattaaatgg 490321 taccccccac ggtagaagca tccttggagt ctccttacac taagtcgtac ttttcacctg 490381 tcccaagcgc gctcttggaa cagaatgact ctccaataat aatgggtatc gatgaagctg 490441 gcagagggcc cgtattaggg ccaatggtct acgcagtagc ctattctaca cagaaatatc 490501 aggacgaaac tataatccct aactacgagt ttgacgactc taaaaaactt acagatccca 490561 tcagaagaat gctgttttcc aagatatacc aggacaacga agaactaacc cagatcggct 490621 acgcaactac gtgcatcact ccgttggata tctctagagg aatgagcaag ttcccaccga 490681 cgagaaacta taacttgaat gagcaggcgc acgatgtcac aatggcactc attgatggcg 490741 tgataaagca gaacgtgaag ctcagtcacg tgtatgtgga tactgttgga ccaccagcgt 490801 cctatcagaa gaaactggag caacgatttc ctggtgtcaa gtttacggtc gccaagaagg 490861 cagactcgct ctactgcatg gtcagtgtgg cgagtgtcgt tgcaaaagtg accagagata 490921 tactagtcga atccttgaag agggatcccg atgagatcct gggttctgga tacccctccg 490981 acccgaagac agtcgcatgg ctgaagcgca accagacaag tcttatgggc tggcccgcca 491041 acatggtaag attctcatgg cagacatgcc agactctgtt agatgacgcc agtaagaata 491101 gtatccctat caagtgggaa gaacaatata tggacagcag gaagaacgcc gcacaaaaaa 491161 ccaagcaatt gcagctccag atggtcgcta agcctgttag aaggaagagg ctgagaaccc 491221 tagataattg gtaccggtga tcacctccag tttgcacata ctatatatct tcatgtaata 491281 ctacatatgt cataacttca ataactcata caagtcatct gctactatgc tttgccgttt 491341 ctactatccg tgaagcgtga ccggcccttc tcaccccccg tgttacgcaa agaacaacaa 491401 gaggtcgaga caaccaaccg gaacgactag aagagaggct gttacgtttc ctgtttgttc 491461 acgctcaaca tcttccattg ctgtaaactg catccagtaa aattaatagt tattagcgta 491521 ctatgtctgc ctttgtcagg gtggttccaa gaatatccag aagttcagta ctcaccagat 491581 cattgagact gcaattgaga tgctacgcat cgtacccaga gcacaccatt attggtatgc 491641 cggcactgtc tcctacgatg acgcaaggta atcttgctgc ttggactaag aaggaaggtg 491701 accaattgtc tcccggtgaa gttattgccg aaatagaaac agacaaggct caaatggact 491761 ttgagttcca agaagatggt tacttagcca agattctagt tcctgaaggt acaaaggaca 491821 ttcctgtcaa caagcctatt gccgtctatg tggaggacaa agctgatgtg ccagctttta 491881 aggactttaa gctggaggat tcaggttctg attcaaagac cagtacgaag gctcagcctg 491941 ccgaaccaca ggcagaaaag aaacaagaag cgccagctga agagaccaag acttctgcac 492001 ctgaagctaa gaaatctgac gttgctgctc ctcaaggtag gatttttgcc tctccacttg 492061 ccaagactat cgccttggaa aagggtattt ctttgaagga tgttcacggc actggacccc 492121 gcggtagaat taccaaggct gacattgagt catatctaga aaagtcgtct aagcagtctt 492181 ctcaaaccag tggtgctgcc gccgccactc ctgccgccgc tacctcaagc actactgctg 492241 gctctgctcc atcgccttct tctacagcat catatgagga tgttccaatt tcaaccatga 492301 gaagcatcat tggagaacgt ttattgcaat ctactcaagg cattccatca tacatcgttt 492361 cctccaagat atccatctcc aaacttttga aattgagaca gtccttgaac gctacagcaa 492421 acgacaagta caaactgtcc attaatgacc tattagtaaa agccatcact gttgcggcta 492481 agagggtgcc agatgccaat gcctactggt tacctaatga gaacgttatc cgtaaattca 492541 agaatgtcga tgtctcagtc gctgttgcca caccaacagg attattgaca ccaattgtca 492601 agaattgtga ggccaagggc ttgtcgcaaa tctctaacga aatcaaggaa ctagtcaagc 492661 gtgccagaat aaacaaattg gcaccagagg aattccaagg tgggaccatt tgcatatcca 492721 atatgggcat gaataatgct gttaacatgt ttacttcgat tatcaaccca ccacagtcta 492781 caatcttggc catcgctact gttgaaaggg tcgctgtgga agacgccgct gctgagaacg 492841 gattctcctt tgataaccag gttaccataa cagggacctt tgatcataga accattgatg 492901 gcgccaaagg tgcagaattc atgaaggaat tgaaaactgt tattgaaaat cctttggaaa 492961 tgctattgtg aggttagaat gaaaataaaa ttcgccagta aatgcgtatc ttggagaaaa 493021 tatcaatttg ttattttgta tatataaaaa attaaaaaaa aaaaaaaaaa aatactcaaa 493081 tactcaaata cgtatacatt atactgaaat acttcgcttg tcttcgaatc taaatcctct 493141 ctctcttctg tctcaaaatg atataaataa atcacgtcaa acggtgcgtc aacatctttg 493201 ttttttcacc tcatgtggaa ttggttgaaa ttaacaaagg agtgggatat aggatataac 493261 gcataaagtt tagcatacta ctttcgtata ttattgttcg gtgaaagaaa ctagttccct 493321 cttatctctc aatatttgcc aaaattagct tttaacaaat aaaccatgag tttcctacca 493381 tcttttatct taagcgatga atctaaagaa cgtatttcca aaattttaac tttgactcat 493441 aatgtagcac attatggctg gatcccattt gttttgtatt tgggctgggc acacacttct 493501 aatagaccaa actttttgaa cttactgtct ccgttaccaa gtgtttaaaa acatcagttc 493561 gatacaactt gggtgagaga ggaagcccat atttccaatt ttgaattact tgaccgttac 493621 tgcaaataat aaaaattgac atgtacataa agtatatata taataaaata taaaattcat 493681 tttgcatatt gttattcttt cacgctttgt tttgatatgg tgaaaattcg aagtctctag 493741 aatgtccttt aggtaccttt ctttaagatg tggttcatat tcaaaaaatc tgatcaatta 493801 gaatttatac cagtgtttta atatgtttat ttatctgtta ttgatattat ttaaaatgtg 493861 aaacaaaata aataaaaata actaaaaatg tagggtggtt tgttgttttg caaaaaataa 493921 aagataagat tgatcacaaa ttcatttcat gaaatttagt aaccgaaaga agccaattgc 493981 ttagcaacat cggattcaga agcagcagca gaagcagagg agaccttttt ggtgaaagct 494041 ctcttcttgg cgtaatattc ggcggatctg acctttctct tgtcttctaa tttagcaaca 494101 acatcttcgt atttccaacc aacagaagta gacaacttac ccaaagtggt gtactttcta 494161 cctggtttca atctcaaaac tctcaaagct tgaggaacga caactctctt ctttttgtcg 494221 tatggaggtg gaataccttc gaagatcttt aaacgttcca aggcagcctt accacgggcg 494281 gtcttgtggg aaaccatacc acgaatagcc ttgtaaagaa ttctagatgg agctctgaaa 494341 tggaatggac cacgggtctt gttgaaagca gtagcctttc tcaaaaagtc gtggtacttc 494401 aacttgtttc tgaagaattc accagaaatg ttcaaagctt cagctctgac aacgacaatc 494461 ttttgaccgt tcaatacttg cttggcaata gtggaggcca aacgacccaa caaatgatcc 494521 ttagctataa taaaaggaga aaaataaagt tagtaaatgc taatcttggt attttttact 494581 gagtggattg aatatagttg gagtcaaaat attgattaga agttaccatt actttttggt 494641 gtgatggggc atatcgatgc atctcagggg taacattggc atgatgcttt caaaccgcca 494701 ctttttaggc gtgatgcacg gtattgcaaa ttcatgtttt caaatataac gcattcaatt 494761 aagtatttgg agtttcaagt attgcgtgtt ccgtttcttc tatgaatcaa tgagcatcct 494821 aattagctaa tactattctt tatagtaagc attttgcaac acatttcgca ggattatttt 494881 ttatttcaat tactatattc tgaaatggtc tttgcaacgt cctccacctg catactcaat 494941 cactcctgtt agaattagaa attttttacg taccatcaat aacaacgact ggttgagaca 495001 tcttttatgg ttggttggtt gtttaatacc ttaacaaaat gcacttagtg gaatatctac 495061 atgtgttata gttttaagaa tcagttttac caatatcaga ataattttcc agaattcgaa 495121 attgcagcgg tccgcagtgc gaatgtttag ccggagggac caagtgtctg cctaagaaga 495181 gatcaccacc ctcccaagct gatacaagga tcaaatggaa aatcacccac ttggggacag 495241 cccaggagac gctttagcgg gcagtttcag gttctaggag cgttctccga aggaagtcct 495301 tctgccgctg tttttcaccc gttggccgaa gcgttgagaa acagccaaat tttctgattc 495361 ataggaaatt tttaaaggag gtttgggtgt gtatagtgta cggattgaat atgtcaagga 495421 tgcaaacaca gcagcgaaaa taaagttcag ttgcataaat tagagtgaac attgcggggt 495481 gttcaaaatc ataaaggtca gatgatcaaa cgcatgagga agagtaaaat agggaatgca 495541 cggtgattaa atattatata tgaaagacag ttatatatgt acttcgtgac atagattcgg 495601 acgacaatag aatgaaagga aagcagctca tatgactggc tgcagcttag ccatttctca 495661 ttcatttctt tagtcttagt gattcacctt gtttcttgtc ttagttgttg ataatactga 495721 tctttgcacc atccgtatct agtattagtt ccttggcatt ggcggtgcta ccaccttggt 495781 ttttcaaagg tgaagaatta atatctttag tttccagatc atttgagtta gagtccgaat 495841 ctttttctga agtagcattc tcgttttctt tggctttaat gtccggattt atggaaaatc 495901 ctctcttgtt gcctccgcta tctgcggcag gagtgttgtt tgttgagcta aactgcaata 495961 aattccatac acctggagaa cttttgacat tctgcgattt acttgttgat ggtgtcagcc 496021 gtctattatc attgtttgat tccatgcttt tcaagacatt agaatccaat actagacctg 496081 tttgtttgtt ttccattccg ctagtctgta aattagaatt atttgcgccg ttattattag 496141 tattgttgct attactatga agaggtgacc tagccctatt agcgcttcct ctttctggtg 496201 tatatgcttc catcgcagta atatgaaatg ccttagtagg agatcgtaat agcgtgtcat 496261 atggttgaga aaggcgtaga ctgttcgctg ccaatgagga agttgttgtt ccagtttgcg 496321 gaactgagtt agaattaccg gaagacgtgg tagttgtcgg ctccaaatta ccattttcat 496381 caagtgaaga agtagatatg gcgggtagat tcattttggt accgccgtta ttgtttgtcg 496441 atttgtcggc gctatcgctg atgttgttta ttattttgga attagcacat gcattagtga 496501 acgagactag agcgttgttt ggagattgcc tattcatttg tgatattgat attgcaggcg 496561 gatgaagtga ctctttgtat tctttcatat tgttttgatt taagttagca tttgaattgg 496621 gagcttgcaa ttgtggcgtc ttgataggtc ttgctaacgc tatatttcga ttttgggtat 496681 ccgcgaaggt aaattgaatc tcttgacgtt gttcctgtgg tggcggctgc tgtgactgat 496741 tttgatgtga cacagggggc tgtgattgtt gcgatgcagg aaggttacct ttggatggga 496801 catgttgtac gaacccttct atgatgttat tgttggatgg ttctagcaca ttgtgagatt 496861 gtagttgtcg tttagggggt tgagccatgt taagcgataa cctatagtcc atttccatgg 496921 gtaaactgtt gaattttgcc atatgtaact gtagttgcct tgctactgag gatccccgcc 496981 tgattttccc cacttttccg gtattccact tgtttagaaa ttcttgctga taagattcgc 497041 taattctcca tttcatacct ttgcccggct cattgggtct tctcggaacc ttttcaaacg 497101 ccttatttaa tgataaatta tgcctaatgg agttttgcca accggattta gcaaacctgt 497161 agtatgcata attggaagaa atatacttgt agatatcggc tagtgaaata actccctccg 497221 gcgacgacag tatggcctgt gttatcatag ttgcgtatga atgaggtggt ttaacgttcc 497281 tgttttcgtc atgggatagg tccgaagtaa aatccaaagc ttgaggatag gcatttgatg 497341 acttgtatga atctacaaaa tttgcagcga tgatggtatt tggaggaccc tgtggagaag 497401 ccgcttgtgg attgatggta ttgcttgttg ttgtagatgc tgtatagttt gggtttatgg 497461 acgtaaagta gccattcttg ttcttactat tattattgtt gttgaagatg ccttgttcgc 497521 tagggcccaa gttcgctccg ctaccaaaag gagcattgcc accacttcca taaagcttaa 497581 accctttgat ttgttgatta gaggttaatt gcctttgctt agcataatta gactgtttta 497641 taatgtctct tagcaggggg ttgttgttgc cttccaatcc gaacatgttt attaaattag 497701 gcatcaggtg ttctatacaa ataggagcaa caaccgggtc actgtcgggc aggataaaca 497761 tcatttgtgt tcctcctatg tctagcaggg ttccggaaga taatcgaatg ggaggattgt 497821 tgggtccatt atgagtcctt tgaaagttta ctttagcgcc gttacggccc aatatgtgca 497881 attcccaacc gccgatattc atgttgtatt ttattatggc gtgctttcta gaaacgactt 497941 tggcaggtcc gagatcaata ttcactctat atgagttttt tacaccatct gaattttcct 498001 gtagtgcact gtttaaggga tcagtatttc taccaataga aacttccaaa tccttcacat 498061 aataggtcca gtttggtccg gagagtttag cataagcttg tatttccgtc gccatgttct 498121 tgtcgttgga atattgtaat gatacggtag ttggctgatc tggggctgtc agtgaagaga 498181 tgatggcatt tattacacct tgatgatgct gagcggtata ttttgtgctg ccataatttg 498241 tttgagtcat atttagttcg ttcatctcgt taaaattgct gctggacatt tcttgcgcat 498301 tgataaagtt tcaataaagg aaacggaggg agcacaccaa tatttatgtg tatcgtactg 498361 tttttttttt ttttttctag caatgatcac ttatgcgagg gaatcgggaa gattggcttt 498421 gaagtgtttt tagccttttg ttccttagta tgatcttgat tattgagcgg ttcaattcag 498481 tggaaaagga ctgctctata gtgttttaag ttttacagaa atatagtgat cctatgaatg 498541 tcactttttt gtttaccttt agaaatgcgg aaccattggc attttttttc tttatttact 498601 aatttaccta gaaaatccaa atggcacagg gcgagcgaat tttttttccc tcttttaatg 498661 agcgaaatcg aagattttcg gtaatgttgt gcgaagggtt ctggggcggg gtccggcata 498721 agtcatcatc aatgctaagg gaacgattat atggcacaga aagagacagg aagaagaggc 498781 catcaaaatg ttgcagctta agggataagc ataaagcgta atcaataaaa aacagcctgt 498841 acccaacagg cagcaaattt ttgaaagcct gttgcaagat acatatgaca caaattatta 498901 aaatatgttg aattaatatt cagttcttac agttgacatg atccgactca aatgttaatg 498961 ttcttgaggt tctatagttt caaaatagct ttttactttc tgctattgga cccttttgga 499021 ccagccgaag gaagtttttt ttctttatgt ttagctcttt tttcatcact tctaattcgc 499081 aaatagaagg ggaaggagga cagcaattat gtaaaaatta attagtatgt cagtaacaaa 499141 aagaagagat aacagaggta gttcctctag acatttttaa gacgactatt gatgccaggc 499201 aaattttgga tttactgctc ctcttttaag aagacaagtg tgtgatatcg tagcggtagg 499261 aaccaatttt gcaatcgatt tacttacagc caagaaaatc tattttcatg tttagcattg 499321 ccatttcttc tgtgtcacac gttgtgcttg ccaggaacta taggagagac gtatacaagc 499381 atcaatgtta cgaatgtacg atcccgtttg catctgatgt gtaaactcat gtggtgcact 499441 ggtgttgttt ccaagactgc actattaact gggaattttt ttttttcttc tagtgaattt 499501 ttttttaaag cgacgcacag gaaaagtgaa aattatttaa acggacggca aacatgaaaa 499561 aaaaaattac caaccatatt tctatttcct ttccctttac ctattctctt tttgaaatag 499621 ttcattttct ctctctgaaa cgacaataaa ccaaactcta gcctccaata gtcactaaag 499681 atgaagtaca ttcaaaccga acaacaaatt gaaatcccag aaggtgttac tgtcagcatt 499741 aagtccagaa tcgtcaaggt tgtcggtcca agaggtactt tgaccaagaa cttgaagcat 499801 attgatgtta ccttcaccaa ggtcaacaac caattgatca aggttgctgt tcacaacggt 499861 gacagaaagc acgttgccgc tttgagaacc gttaaatctt tggttgacaa catgatcact 499921 ggtgtcacca agggttacaa gtacaagatg agatacgtct acgcgcattt cccaatcaac 499981 gtcaacattg ttgaaaagga tggtgctaaa ttcattgaag tcagaaactt tttgggtgac 500041 aagaagatca gaaacgtccc agttagagat ggtgttacta tcgaattctc tactaacgta 500101 aaggacgaaa tcgtcttatc tggtaactct gttgaagacg tttcccaaaa tgccgctgac 500161 ttgcaacaaa tctgtcgtgt tagaaacaag gatatccgta agtttttgga tggtatctac 500221 gtttcccaca agggtttcat tgtcgaagac atgtaaatgg aacaaaaaag tgtctttgcg 500281 cttagaggcg cttaaatatg tacattattc ctactttttt atttagtatt atgtaaagac 500341 tgaggttctt tgtcattgga tgtgcctcac ttccaatgat gaattgacag gctctctagg 500401 gaatgctgtc aaggggaaac gttgctagtg ctcattgaaa taaagagcca ctttacgttt 500461 tctcaaattg cttttgtttt ttcttctatt gatgctaatt gcatattttt tggtaaagga 500521 aagaaacact aaaaaataaa tattctctaa tacgttacaa atgattttct tttttcttga 500581 gtcttgcaat catacccgta gctttctctt gttcttcggc tattgcttta aatcaaaatg 500641 atatctgggt gtaccagcaa gtttcgaaat gaaaacataa aaatatggtt acccgacata 500701 tatgctggtt taatactggt taaactgaac agaagcatct cttttctcta ttaggacgta 500761 aacgacaacg ttttttttta taggaaaagt aaacaaagcg cagtggaagg cagcgaaagg 500821 aacctgcaca gcgcgaagtt tataaacaat gacttttcca gatctcggat ttttttctcg 500881 cacgttccct tcagcatgaa tcttatttaa acacttactt tcgagaaaaa taacagtagt 500941 ttccccaaaa aaaatagtac tatcacacgt attttaaata taatcgccgt attattcact 501001 atattcaatt tcaactttat agcaagaaaa ggaaagatcg attcgttctt ttaccattat 501061 ccaactactc tacactcctt tttcgccgaa gaaaagaact cttccaacta attttcactc 501121 ctttaagcat tttttttttt tactttttta caagtcgtat gtttaattta atgataagac 501181 ctttcatgtt actatatttt gagtttgcaa attattccac tgattacgaa attgctgtgc 501241 ttttttcgct tcggtgcatc gtcatttttc gagaataaag caaattttta catgcccgtt 501301 atttttccgt gcacaacttc tttttggctt ttttggccgt cggatttacg gcgcgaaaat 501361 aagtttctga cttctcgaga tatagccatt gtagaaacta aaacaatatt gattgattca 501421 attagcacta atcttagaaa atttgcaatc ctactctttt cgcaatgatt ttatttacta 501481 acccatccca aatttatttt agtaatttga taaaatgaaa ctgtccgcca ccactcttac 501541 cgcggcttca ttgatcggtt atagcacaat cgtttccgct ttgccgtatg cggctgatat 501601 tgacacagga tgtactacta ctgctcatgg ttcacaccag cataagaggg ccgttgcagt 501661 tacatacgtt tacgaaacag tcactgtcga taaaaatggt cagaccgtca ctccaacctc 501721 aactgaagcc tcttctacag ttgcttccac tactactctg atttccgaat cttcggtcac 501781 caagtcttct tccaaagttg cttcttcttc tgagagtact gaacaaatcg ctaccacctc 501841 gtcttcggct caaacaactc tgacatcttc agaaacttct actagcgaat cctctgtgcc 501901 tatttccaca tctgggtcag cttccacatc ttcagcagct tccagtgcaa ctggaagtat 501961 ctacggtgat ttggctgact tttcaggtcc atatgaaaaa tttgaagacg gtaccattcc 502021 ttgcggccaa tttccatctg gtcaaggtgt tatccccatc agctggttag atgaaggtgg 502081 ctggtctggt gttgaaaata ctgacacttc tacgggtggc tcttgtaaag aagggtctta 502141 ctgctcatac gcttgccaac caggtatgtc caagacacaa tggccttctg accaaccatc 502201 tgacggcaga tccattggtg gtttgctatg taaggacggc tacctgtacc gttcaaatac 502261 agatactgac tatttatgcg aatggggcgt tgatgccgct tacgtcgtct ctgaattgag 502321 caacgatgtt gctatctgca ggaccgatta cccgggtacc gaaaacatgg tgattcctac 502381 atatgtgcaa gcaggtgact ctttaccctt gactgtcgtt gatcaggaca cctactacac 502441 ttggcaagga ttgaagacat ccgcgcaata ctacgttaac aatgccggta tttctgtcga 502501 agatgcttgt gtttggggtt cttcaagttc aggcgtcggt aattgggctc cattgaactt 502561 tggcgctggt tcttctgatg gtgtcgccta cctttctttg attcccaacc caaacaacgg 502621 taacgcattg aatttcaatg tcaaaattgt cgccgctgat gactcttcta cagtcaacgg 502681 tgaatgtatc tatgaaaacg gtagcttcag cggtggctct gacggttgta ccgtttccgt 502741 tactgctggc aaagctaagt ttgttctata caactaaact taggcgcatc aacagttgag 502801 taagttgatt gtattattac cccattcttt tctgcccgtc cattttattg tctgtttaac 502861 atacactaaa acccacgccg gattaatatc aatttttttt tactttgttt ctatttatca 502921 ttcttccaga cataaattat tttgtaatat taaagacatt tgaaaaccta catacatcgc 502981 acacctcttc tttcattgtc ctaaaaacca cccaaaaaaa aaaaaaagac atcaaatctc 503041 tttttttttt ttttgtagtt ctgttgccgt atgctatcta ctcctaaggc ttttttctac 503101 tacggcaatc tattcacaat gtgcaattag gctaaatgct aaaaaaagaa aaaaaaatcc 503161 ggagcccctc gatgactcct gtttccgttt tatactgtcc agcgcagacc gcacttccta 503221 cgtatacttc ttacggggaa gggagcatac acgaaaacaa aaggacccgt aatgactcgg 503281 aaactccata gatcggtaaa taccggctcg ttacccgtcc tccatcggaa aatctctcac 503341 cgatttgttc cggtatcgga taatttatga atcacccggc ttgatggaac cgtttttgtt 503401 ccgtgaaatg cccggcctgc attgttttct tcagacgaga agccgttcca acgtttcttt 503461 ttctcgtcac cgggaagttg cgggcacctt agggcaagga aaaagaaact tctctgccct 503521 catcgaggat acagttgatc atactcaata ttatataacg cttaacactg tcaaggttat 503581 acacttttta ctaacttttt attgctaata ttgtcgttct atataaaatt atggattttt 503641 ccaggcttac aaagttagca tttatacgga gataaattta tttttttgag aatccaagct 503701 agattcagaa agtcgaatca gcaatgtcac gaagtaacag tatatacaca gaagatattg 503761 agatgtatcc tactcacaat gagcagcatc tgacgagaga atacacaaaa ccagatggtc 503821 aaacgaaaag tgaaaaacta aatttcgaag gcgcttatat caacagtcac gggactctat 503881 ccaagactac cacaagggaa atagaaggcg atttagactc tgagacttct tctcactcca 503941 gtgatgataa agttgatcca acccaacaga taactgcaga gacaaaagcg ccatatactt 504001 tactaagtta cggtcagaag tggggaatgg ttgcaattct aacaatgtgt ggcttttggt 504061 cttcattggg atcaccgatc tattatcccg ctttgaggca gttggaaaag caatttaatg 504121 tggatgaaaa tatggttaac gttactgtgg ttgtgtatct gttgtttcaa ggtatatctc 504181 ccacagttag cggtggtctg gcggattgct ttggacggag acctataatt ttagcaggta 504241 tgctgatata cgttattgca tccatcgggc tagcatgtgc tccatcatac ggtgttatta 504301 tcttcttgag gtgtattcag agtattggta tttcccccac aattgcaatc agttctggtg 504361 ttgtcgggga cttcactttg aagcatgaaa gaggtacatt tgttggcgcc acctcagggt 504421 ttgttttact gggtcaatgt tttggtagtc ttattggtgc cgtcctgact gcaaggtggg 504481 attggagagc tatcttttgg tttttgacca ttggttgtgg aagttgtttt ctaattgcct 504541 ttcttatttt gccagaaaca aagcgaacca ttgcaggtaa cctttccatt aagcctaaaa 504601 gattcatcaa cagagcgccg attttcctac tgggcccagt tagaaggaga ttcaagtacg 504661 ataatcctga ttatgagaca ttagatccca ccattccgaa actagatttg tcatccgccg 504721 ggaagatcct tgtattgcca gaaattattc tgtctttatt tccatcaggg ctcttatttg 504781 ctatgtggac gttaatgctt tcctctattt catccggttt atcagtggcg ccatacaact 504841 atcatttggt cattattggt gtgtgttatc tacccggtgg tattggcggt ttaatgggtt 504901 ccttcttcac aggtagaatt attgacatgt atttcaagag aaagatcaag aaattcgagc 504961 aagacaaagc taacgggttg attccacaag acgcagagat taatatgttc aaagtccgtt 505021 tagtttgtct tctgccccaa aatttcttgg ccgtcgtagc ctatctttta tttggttgga 505081 gtatagataa gggctggagg atcgaatcta ttttaattac ttcatttgtc tgttcatact 505141 gtgctatgag tacattatca acatcaacta cgttattggt cgatttgtac ccaacgaaat 505201 catctacagc aagtagttgt ttcaactttg ttaggtgcag tttgagtacc atcttcatgg 505261 gttgctttgc caaaatgaaa gctgcgatga ctgtaggtgg tacttttaca tttttatgtg 505321 cgctggtatt tttcttcaac ttcttaatgt ttattccgat gaaatatggt atgaagtgga 505381 gggaggatag attattgaaa caacaaagac agtcttggtt aaacaccttg gcagtcaaag 505441 ccaaaaaggg aacaaaaaga gaccagaacg ataatcataa ttaattggca ttcttcaatt 505501 tgatagacac ttatccctgc atattttttt tataaacagc ttatagactt tcatgtaaat 505561 ttttcctaat taatgtatta tttacttcgt taattttccg ttgaattatt gacatgttaa 505621 aggtgcacta aatataccta atacaaaaaa tggttttctg tggcaaatat atacagtgga 505681 aatttcagca tataatccct gctttactct ttccttaaga tttcgtcata attagaactt 505741 tttttggtaa actgcatttt ctaccattat tactttacat atgtatagct acaaaactgt 505801 attttgaagt gaaaagtatg atgaataaat gaatcgtgaa taagttgatc tttttttatc 505861 aagaaaatca ttgagatgca cattgaacac cttcgccacc ttgttcttct tcatcggaat 505921 catagtttgc accacccctg gaggcccgtg ttctgttgta tttggctggg tcaaagtctg 505981 cgagtacaca ttcgtccaca gtagctttct ttggaatggc tgggacaatt cttggaggca 506041 aaatttcttc taacttcttc aagttttctt ctgatgtgaa atggttttct gggaacttga 506101 tagtaaattt gatgattaaa ttaccatagc caccgtattt tggaattggc atacctttac 506161 cttcgatgac cttacgcata cctggggcaa taacttcacc tggaacaata ccgaccttta 506221 accaatcacc agaaacatgt tccaatgcaa attcaccacc agcgatagca gtcaatagat 506281 caatttcagc ctcatatact aaatcatcac catctctctt gaagctcttg tgtggtctct 506341 cagaaactat gaagacaaca tcacctggaa tgacatctgg ggcttggtca gcttcacctt 506401 tgaaaacgat tctttgacca tctttcatac ctggttcgac atggacttct aggatcttcc 506461 tttcgttttc aactttctta ccgttacaag atttacaacg atccttagga tcaatgatat 506521 caccagtacc gtgacagaca tcacactctg tttggaatct ttggatcatt ggacccattt 506581 gtcttgttac aaatttaata ccttgaccat tacagctggt acacttcttg acggcgcctt 506641 tcttaccacc acgaccttca cattctttac ataggatctg tttgttaagg gctaacttag 506701 ctgtcctacc cttatataat tcttcaagtg aggcagaaat ttcatgcttg atatctttac 506761 ctctttgggg acctcttggt ctttgtgcgc caccagcacc aaagaattgg gaaaagatat 506821 cgtcaccaaa accgaatcca ccacctggga atccgccagc gccaccagca ccacttagac 506881 catcttcacc aaattggtca tatatatctc tcttttcagg atctgataaa atttcatagg 506941 ctgctgaagc ttctttgaac ttttctgcag cttcctcact tggattctta tctggatggt 507001 attttaaggc gcattttcta taagctttct taatttcgac atcagtggca gttactggaa 507061 cacctagaat atcgtaaaac ttagtttctt taaccatctt tggacgttta ttattgttgt 507121 tggaagatgt agaattcagt ttggataatt tttaattatg ttctatcaaa agatatggta 507181 acaaataaca aaaaaataaa tacgtaacag ttatcaaata agacgcttgt tcgggcctaa 507241 tatatatggg gaaaaggact ttttgtgact ttgatttata aaaacgaact acacacctta 507301 tcaaacaaga actacctaac caacatataa acgtagagca agtttttaca cgttttataa 507361 gtacgtggat tgatctgcaa gttaaatact ttccatacct gccgatgctc tattgccttt 507421 tcatttcttg aaaaagaaat gaaaaaattt tctatttttt cgatggcctt ctataatttt 507481 gtacgaaata ttataggtca ggtgtatatc acgtgctcaa accagcgact tcacatctta 507541 ttttatacca acatactcat tataacaatg tattccatag ttgaatacac acaactcaaa 507601 cgtgtataaa cgactttatt ttgccgactc tctacggtca atgtcttgtt acgttttcaa 507661 gtgcttttag aaactctgca ctctcttccc cttaactcgt agacaaggag cgatagttga 507721 atggtaggaa cgaaaaagaa acggttagaa agaacatatg cctcgaatat ctacatcatt 507781 gataagaaaa gcttcgagaa tacgacctgg tttgcatctt ttgcttccag aatgtaggac 507841 tctcgagcaa gcgaaactcg agtacaaatg gctcaccgaa gagctgcctc cggataaatc 507901 aatccgctgg gcttgcttac agagatacaa acacgtccca ttgcagtaca tcttaagatc 507961 gcaaccgttt ggggccttgg acatagtttg caagcctggt gttcttatac caagatggga 508021 aaccgaggaa tgggtgatgg ccataataag agctctaaac aactctatgc tttcaaggca 508081 tactatacca ctgcatattt gtgatacgtt tacaggaaca gggtgtattg ctctcgcttt 508141 gagtcatggt atagcaaatt gcacgttcac tgccattgac gtgtcaacaa gagcaattaa 508201 gttggttaaa gaaaatatgc tgaaaaacaa ggtgagtggt ggtaagctcg tgcaacataa 508261 tatattgtcc tcaaaagcta gcgatgaata tccatcccat atagatatat taaccggtaa 508321 ccccccctac attcgaaagc gtgacttcaa tagagatgtt aaaacttccg taaagctgtt 508381 cgaaccaagg ctagcgctag tgggtgagct tgaatgctat ataaatctag taaattattg 508441 gctgccgaag acagactcct tcttttatga gattggagac gttgaacagt ttaattacgt 508501 ggagaggcgc attaaagaag attcatatct cagccgtatt tggtctattg gtttgaaata 508561 tgactcgaat gggaaagcaa gagtcgtata tgggtttaag gccactccca aagggcgaat 508621 actacaccag atttttgcat cctttgggac tataagacat ttagcaaccg cactcagtgg 508681 gcacaaagct aattgcaact aagtatataa atgtaaatat atatattctc aggttttttt 508741 gttggaagtt atcaaacgga acactctgtg gacatttata ttttttgttt cttagctcca 508801 tgttcagcaa gcttttcact ggagtcagct gcagtcgcgt tttccgatac aggttcagga 508861 gcagggatga ctctgtgaca ccacattaga tatccaccac cacctttcat ggtcatcaga 508921 gggtgtagct taccccttat actttggtac ggcctacatc tagtttccaa aattgatggt 508981 gctaaaaacc tgaggtctga atataaagta tgagctaatt ccaacaaagt ttctttgaat 509041 tgaccatagc atacaatcgg ccttgaacca tggatttttt cggccaactt tggcactagt 509101 gttggtaaat gtagtgtagt agccattaca agaccgtcat ataggaattc tcctgttagt 509161 tctaaaattt gccattgtgt attgtaccat ctgagttttc ggtagtacga gtttttctta 509221 ccacctttta atgcacgggc ttcttcttta ggtaatggtg taaatctgct ctgaatctct 509281 tgtagtgtag gcggttcaaa aaaatctaat agagaaatgg tgtgtacatg ctctttaata 509341 aatttctcag aataattagc aaacttcagc aaatccaagt tggcatgttc attttcgtga 509401 ataactatga ctttgccctt ggatttgctt tcattgtcac cgccaaacat tctttccaac 509461 agaaagtaaa ccaataaccc acccgtttca tccatacaga gatagttgcc ttctgattgg 509521 atgttcgcaa gatttaacag catccccatc gattcctgag acatatccaa taccctttgg 509581 atatcgcctt tgtcgattaa gaattgtaaa aggttagagc tacttaaata ctcaacggtg 509641 aagtacttgg cgaatttttg tttcttccta ttcacatatt tctcttgaga atatacggtc 509701 ttgttgtgaa aacttttgtg agatttgata attttgtcga ttatttcttt actagataaa 509761 gattcttgtt tcattttttc aatttcttca acggttaact cttgggcctt gctgcccatg 509821 ttaaccagat tctgattcgt agcactgctg tcaatgctag acaattcaag agacacagat 509881 ttttccttaa tagataaagg aggctcgctt tgaccatcgt ctttatcatt attgacatct 509941 ttgatctcct gcgataatag ccttactttc ccgatgggaa ttttgttctt tggtttcgaa 510001 tctctatttt catcggatga aacctcttcg ccatcataat atatctcgaa agtcaacccg 510061 aaaggataac caattatgtc attaacctcg aaagcaccga attttcctaa tgatacagag 510121 gtgttgggct ttagttccac tatcttgtaa ttttttgatg gcagccggac gataacgtgc 510181 tgattaaaat ctatggttgt caaagcattc attgtgcact aaattcaaag tttttttgtc 510241 caattcgttt gcaacaatgt gagtaggatc caacgtgcca aagaatttaa agttgaatat 510301 tattattgtt attatacacc tcatcgactt tttttttttt tttgatgaaa tttttcagat 510361 tttacaaaac cgttacccag tttcacgttt tctgaaaaaa attttcatct catcgcagaa 510421 taagtttaag atgagctgag ctgcaaatac agttgtcgct aaggtatata gatttgtaat 510481 tctggcggaa ttccccttgt gttggctaat attagaatta catatacata taataggaaa 510541 tgggtagtag acgtcataag aacaagcaag ccgccccacc aaccctggag gagtttcagg 510601 caagaaagga aaagaaggct aatagaaagc tagaaaaagg aaagagacct tctaccacgc 510661 aaggggatga agtttctgat agaaagaaaa agaagtcgaa gccattcaag aaatctagaa 510721 aagaggagga agaagttgtt gaagaggata aggatttgcc agaagttgat cttgaagaat 510781 tatcaaaagc caggaaatct ttatttgatg atgaagaaga tgacgatgaa gcaggattgg 510841 tggatgaaga actaaaagat gaatttgact tggaacaaga atatgattac gatgaagatg 510901 aagataatga cgcccaccca attttttcag atgacgacga tgaggctgat cttgaagaac 510961 taaatgcaca aaacatggaa gctctttcta agaaacttga tgaagaagaa gctgaagaag 511021 ctgaagaagc cgaaatggag ttagtggaag cggagaacat gcaaccaaga gcagacatat 511081 tgcccactga ggagcaggaa gaaatgatgg cacaagaaac tcctaattta acttccacaa 511141 gaacaagaat gattgaaatt gtaaaggttt tggaaaattt taagactctt ggtgcagaag 511201 gcagatcgag aggagaatac gttgacagac ttttgaaaga tatttgtgag tactttggtt 511261 atacaccatt tttggcggaa aagttattca atctattctc accagcagag gcgatggagt 511321 ttttcgaagc caatgaaatt gcaagaccaa taaccatcag aaccaacacc ttgaagacca 511381 gaaggagaga cttagctcaa actcttgtga atagaggtgt taatctacaa cctattggtt 511441 cttggactaa agttggtctt caaatattcg attcccaagt cccaattggt gctacgccag 511501 aatatttggc aggtcactat attttacaag cggcatcatc ttttctacca gttattgctc 511561 tagatcctca tgaaaatgag cgtatcttgg atatggcagc tgctccaggt ggtaagacca 511621 cttatatatc agctatgatg aaaaacacag gttgtgtttt cgctaacgac gccaataaat 511681 ctagaacaaa atctttaatt gctaatatcc accgtctagg ctgtaccaac actattgtat 511741 gcaattacga tgcccgtgag ttccctaagg taattggagg ttttgacaga attttactgg 511801 atgccccatg ttccggtact ggtgttatcg gtaaggatca atctgtcaag gtgtctcgta 511861 ccgagaagga cttcattcaa attccacatc tacaaaaaca attgcttcta tccgccattg 511921 attctgttga ttgcaactcg aaacatggtg gtgtaatagt atattcgaca tgttctgttg 511981 cagtggaaga ggacgaagct gtcatagact atgcattgag aaaaagaccg aatgtcaagt 512041 tagtcgatac tggtttagcg atcggtaaag aagcgtttac tagttacaga ggcaaaaagt 512101 ttcatcctag tgtgaaatta gcgaggaggt actatccaca tacgtacaac gtcgatgggt 512161 tctttgtcgc taaattccaa aagatcggtc catcttcgtt tgatgataac caagcaagtg 512221 caaaagaaaa ggaaactgct gctagaaagg aagctttgga agaaggtatc attcactctg 512281 acttcgcaac cttcgaggac gaagaagacg ataagtacat tgaaaagtct gtgaaaaaca 512341 atcttttgaa aaagggtgtc aatccaaaag ctaaaagacc ttctaacgaa aaataagttc 512401 ccacaaacgt agtggcatca tgttagcata gttttctctc tctaatcttt ctctgtctac 512461 atatatatat atatatatat atatcaattt caaatatgtc tcactgtata ttaaattcaa 512521 aatagaaata ataaagccga tttgtaaaca gcactaagaa aaaaggcgat gatattactt 512581 attaatattc gttgccaata tagtattaca tatatctcta tttatttctc tttttttgtt 512641 tttaaggcgt ttcagtttgc tgtctcctta gtcttcaaaa tacttcgtat tccctaactt 512701 atgctctttg atgtactctg gaccgtactc ttcgtattct ttcttactga taactgtttt 512761 cctatactgt tcttcgtttc gtgctagagc tgccataccc ttccaggcat ccaatgaagg 512821 atctgaagac atatttacag tgatattggt accggtagga aggaatccag tgaattcctt 512881 cacaatacgt tctttcaatc ctggcacctt agcattaccg ccggtaataa gaacgttgtt 512941 caccatgtct atggaagttt gactcaattt tcctggttga gaaccaaact tctttagtaa 513001 aatggtttct gataattcgc aaataccggc ttggtcttgt ccgcccattg tcggttgaaa 513061 tatcacttct ggtaccctta tacgttctac attcaaatgc atttgatgtt gttcatgtat 513121 attttcgcta tcatgaggtc taggtcctct taaaaacagg tggaggatag aatttctcca 513181 atcgtactgt gcttccagcg tatcttcttc agtaaagttt ggatcgtgtt ctaaaagtag 513241 tctctccagt tccacgatgt ctttgtactc gtactctaat gcttcttcaa aagcctcagg 513301 attttgagta atatcagtat aaataagcca gtcttcatca ttagcgccaa aagtgtcatt 513361 tggatcatta tctattgtcg cttggtgtct attacgtttg gccccttgtt tgacattatc 513421 ctcagccaat gaagctagat ttttcattct gttctgtgaa acttgagatt ttctgtcctt 513481 catttcgtca cgtagtttta acttttcttt tctccttttt attaatttgt ttaatttcaa 513541 tcttttgtcc tttatccaac catttaagtc agtttcacgc cattgttgct cttttaattt 513601 tttttcttct tcttccttgg cgactctttc cttttcttct ttagcctttt gcctggcgtc 513661 ttgactggcc ttcaaaaatc tttgcttcct tttctccttg atttgatctt catttagatc 513721 ttcgtctgca atatcaagca aatcaaattt ctgggctgtt ttgtcttcat tcatttcatc 513781 caggtgacta tcatcttctg cttcaaccat ttgggctttt tttaatgatt gttctaggct 513841 atgaagatac tttttaaaat cacgttcgtc atcaaaacca gcgttttgca aaaccgagag 513901 tactttcttc ttaggttcgt caattaattg gtctctaact tttgagaagt attcaaattc 513961 ttcctgcttc tgaaccaatt tttccattct tttcaaacgt gcctgttctt gcaagcgttt 514021 cccagtttcc tttctttttt cggcttgaat tcgtaattct tcttctgtct tttgaggttg 514081 aaggacttct gtaaaagggg cttccactac cacatcattt gtatcaaggt tctccaaggt 514141 gaggattttt tcaatatctt catcataatt tcgcgaaaca tagcaataat ctttatacat 514201 cgtttcatac tgcaaataag acatctttgt tggaaaatat ggatacttca aagccatcaa 514261 atcattcaag tagtcaactg cttgatgtcc tccccaatta atcctttttg catctgtcaa 514321 gatacctgca ccatcaacta cgggaattac attggtgtcc tcatggccac aactgatgac 514381 caaacctgtt ttatttccgc ttgggttata attgtaaaaa ctaaacagac tgtctattcc 514441 gaaagtaacg cctggtacat tgtaagtttc aaacaaaatc tggtaccaat ttgtccgttg 514501 tgattgaaca gttgccagtc tttcggtaag taatattgga ttaggaattc cgttatctgg 514561 taccactccc aaatgatgaa aagtgtagtc caatatttct tcagtgagat tccaattggt 514621 tacaaatggt ccgtcaaagg ggcttctcga ttgcgaacgc acagcttgat ccaacaaggt 514681 gtcattaccg acaaaagtga aatttttgtt taactttctg tctctaaact tggtcaatgc 514741 attcggaaaa atatgtgtag gggtagcatg gttaacgaat cctgctctca gtttgcttga 514801 tccaaaatca atggcaatgg gcgactgggg attgtaagct gactgttcat cgaatggttc 514861 tggggtttgt ctcaatggag ggtcgtctat cactactgcc ttaagaggag tcaaagaggc 514921 gtctctgcta gacattatac gtcttatgtt cagagtcctt cgaaatttca cttttataac 514981 aagtttttac tgagaaccgc tgcttatatt gattattata ttcttcccaa agtgagtatt 515041 tcataagcgt tgtaatgatg tatcatagtc tacgaaacga gataaatgct aaacgctaat 515101 tatagttgag aatttacaac gatgtaagtc gcactaagcc aagaacttct ttcgatgatt 515161 gtcattgctc ttagcaaact gttcattgtg agttttgtta cttgctgaaa attacatcgg 515221 tcaagaccct tctatattgt caccttccat ttatgaagac agcacttcaa ggcaaaagtg 515281 tttaatattt atacgcggat catgattgct tagctccttc tttaactcag tacttgtggt 515341 tagaattttg tagatacctg cacacatttt ggtagcagct gtgtcggtgt ttcatgagga 515401 tcggaaagat atgtacggaa agatcacatg tatatattta acaaagaatg cataattcgc 515461 cttgttgatg gttacgacca gatcagataa agtagttcaa agatcacaac agaattttat 515521 ctttccaatt accattcaga aaaatttttt atctcttgga gggttatttt cgggcctttc 515581 aagaatatga taaagatata tcttggcaga tgtactgatg attactggtg cgttagaacc 515641 gtatggcctt gaaaagaata aaagcaaaca tcgatttttt tggtactgaa ttacacaatt 515701 tttaaggact aaaaaaaaaa atgtttaacc tgaacaacca tgtatcttag atgtcagggt 515761 atctagatta tttctctacc attcaggaca tcatccaaaa acatcgatgg cgcctgtctt 515821 ttatgagcct ttttaggaga gctagtattt gaggtagcag aagcgactgg tatgaggccc 515881 aaggaggatt ggtttctctt atggtagcct tccattgagt taattttctt ttcctttctt 515941 tcaggtgacg ctgctctttg tggtctattg aggttcagct ttctctcttc ttcttcttct 516001 tcttcttctt ctagataggt acctacgtat aaaaatggat cgtcaataaa aatgttagtg 516061 tcttttgatt gatggcggct atgacttttt tcatattgtg acacttgtaa agtaggagat 516121 ataaataagg atcttctgtt gtctgtgaac ggatcctgaa ttgggttgaa tggtgaggca 516181 gcatcctcgt attggctaga ttctaattgg ctcatagaat cccaatcatc ctgcatatat 516241 gatttctcat cattgatgtc aaagggattg ctttgtaaag aagaactatg cttgtggtgt 516301 cccctgtaca aatttttact atcatttgca taagaatttg tcattgtgaa acgacgagac 516361 aaataactgg acactaacca ccatataaga atactgataa aaatggcacc tatgacagca 516421 cccacagcaa tgtatacagt tccatttggt ttatcagcag catttaaaat aaatgggttt 516481 cctgctgtag atgggggtgt tatacttgcg acaattagtg atgaggagga tgttgctcca 516541 ctggaagttg agaaagccga agatgttaac gatggaaggg acttggaact cgtttcggac 516601 actacacttg acgtgggctt tgacagggcg gttgaactag ttgtagtagt aactaaagta 516661 ggaaggtctc ttctgaccag cgatacagac gggataaagt ttttcttaac catctctgcc 516721 gatgtttctt tctgaacttt tgacaaggta tgagtctagt tgattataat acaagagtgt 516781 gggtatgtta ttaataaaca ttataaatta ttaacccata tagctgctaa atataattga 516841 aaatctagta atttctaatt atacattttt tttttttaca aatgttttat gatatgttta 516901 ctatttcccg ctttaggaaa tcatattaag ggtttcatga aagaattctg cagagtgatc 516961 attggaaatc ggcagaaagt gagaagggag gctgtcacca ggttccccta tactattcat 517021 gtgagtggta gcatgcaaag taaagaccct ttttcattta gtgattcatc catgaatagc 517081 tcttggtgct agcccagatt tttcagtaat ttttgttttt tcttctgaat tttccagaat 517141 taaaaaaaag atcagaaaaa agcgagagtt tacttaagat attaaagtct agttgatata 517201 tcaacaagtg aaggcaaaat accaatagag tgcacgtttc ttgatgctat gaaatacata 517261 cccccattaa atttttcgcc agtggtgagc acggatgtat cgttatatcg atcgggatac 517321 ccgatgccgt taaattatag tttcatcaag catcagttac acttgaagac cataatatat 517381 attggcgata aagataggcc tctcgaagaa tatcaaagct tcctggagtc agaaaagata 517441 aaatactatc acatatttat ggattcaagc cgcgatgaag gaattcaaga aagaatgaac 517501 caggtcttgc acttggtgct ggatgtcaga aactatccca tcttagtgca ttccaataag 517561 ggcaagcacc gtgttggtgt agttgtggga atcataagaa agttgttaca gggatggtcc 517621 actgcaggta tatgccaaga gtacgggtta ttttctggtg ggatgaaaga tggagtagat 517681 ttggagttta tcacaatgtt cgaaaccaat ctgaaaatac cgagaaacgt tatccctggc 517741 tttgctaaac actgcttgta tttgaatgag ctagaggctg cggaaggaag tgatgatgag 517801 tcaggaagtg agtctattct cactgccaag caaccaatat gattatgaga accagccgtt 517861 acaaagaata ttttctgtca ttaatatatt tgtataaata aaacaacaag tctaaagatc 517921 aagtagaaaa atggaaacaa gaacgagcac atatatggta tatagtgaac atatatatat 517981 tagatatata cgttcaagcg tcgaaggaca aagaccaacc tagcttgtga acaggttcag 518041 acaacttcaa agcatcgaaa gaggaaccga cacccagagt gacgccaggt cttaacaatt 518101 gcttgtaagc caaagtgaca ataccggaat cggacacctt agccttaact tgggaagatg 518161 catcaggcaa atatctagtg gcgaattcga tgttgacatt ggagttaggt agtttgcagt 518221 tcattgtagc cttagcaccg acctgtaaaa aggcgttgac gttttggaag aagtcaacgg 518281 tagttatttg ctcgttgttc aatgtagcgc ccaaggagta gtctttggcg aaataactta 518341 aagccatggc ataacgagaa atggaaccgg cgctgatatc gtaaccaaac tctgcgccac 518401 caacaatacc ttcgtgggcc atagttaagt caccaacaaa tgttggtgac ttcaaacaca 518461 agtcaaaggc acctcttgcg gtgaagaaag gttgtgtgaa cgtagtgttt aagacggcgg 518521 acttggcgac gcctggagtc aaagaagtga tcaattcgtt ctttagacca ggggtcaagt 518581 tggcaaactc taatttggtt tgcaagttgt ttgtgttaga ccagccttga gttagaccca 518641 agccggtttg cttgtcattc aactttgctt ccacgttagt agacagtgga ccgtctttga 518701 caggctgttt agccttcaat gagaacttaa tgccattggc ggttgttgtt tgcacatcaa 518761 aggcagctgg ggtagcatga tagaaatcct tgttcaatag gtcattgata tttctggaga 518821 tatcgctgta aactggagga gacattgttg agaggttggt ttgatttttg ctttgggtac 518881 gcttggctgt ttcgtgttgg gagaatccgt agcactaatg agtagtggaa cgagttgggg 518941 gtagttatat agtagatcaa ctcgtgctct gctggctata aaaggggttc tttgttgagg 519001 aacggccgaa atggcggtgt ttgattgggc cgcagccggc aaaaagcacc ggaaccgtga 519061 aaaaagctcg tctgacgcgg aaacgtgcgg caaaaaatct ccgcgacggg gaattgaacc 519121 ccgatctggc acgcgacaag cgcccattct gaccattaaa cttgttggaa taaaaatcaa 519181 ctatcatcta ctaactagta tttacgttac tagtatatta tcatatacgg tgttagaaga 519241 tgacgcaaat gatgagaaat agtcatctaa attagtggaa gctgaaacgc aaggattgat 519301 aatgtaatag gatcaatgaa tattaacata taaaacgatg ataataatat ttatagaatt 519361 gtgtagaatt acagatttcc ttttatggat tcctaaatcc tcgaggagaa cttctagtat 519421 attctgtata cctaatatta tagcctttat caacaatgga atcccaacaa ttatctcaac 519481 attcacccat ttctcatggt agcgcctgtg cttcggttac ttctaaggaa gtccacacaa 519541 atcaagatcc gttagacgtt tcagcttcca aaattcaaga atatgataag gcttccacta 519601 aggctaactc tcaacagaca acaacacctg cttcatcagc tgttccagag aacccccatc 519661 atgcctctcc tcaaactgct cagtcacatt caccacagaa tgggccgtac ccacagcagt 519721 gcatgatgac ccaaaaccaa gccaatccat ctgattggtc attttacgga cgcccatcta 519781 tgattccgta tacaccttat caaatgtcgc ctatgtactt tccacctggg ccacattcac 519841 agtttccgca gtatccatca tcagttggaa cgcctctgag cactccatca cctgagtcag 519901 gtaatacatt tactgattca tcctcagcgg actctgatat gacatccact aaaaaatatg 519961 tcagaccacc accaatgtta acctcaccta atgactttct aaattgggtt aaaacataca 520021 tcaaattttt acaaaactcg aatctcggtg gtattattcc gacagtaaac ggaaaacccg 520081 tacgtcagat cactgatgat gaactcacct tcttgtataa cacttttcaa atatttgctc 520141 catctcaatt cctacctacc tgggtcaaag acatcctatc cgttgattat acggatatca 520201 tgaaaattct ttccaaaagt attgaaaaaa tgcaatctga tacccaagag gcaaacgaca 520261 ttgtgaccct ggcaaatttg caatataatg gcagtacacc tgcagatgca tttgaaacaa 520321 aagtcacaaa cattatcgac agactgaaca ataatggcat tcatatcaat aacaaggtcg 520381 catgccaatt aattatgaga ggtctatctg gcgaatataa atttttacgc tacacacgtc 520441 atcgacatct aaatatgaca gtcgctgaac tgttcttaga tatccatgct atttatgaag 520501 aacaacaggg atcgagaaac agcaaaccta attacaggag aaatccgagt gatgagaaga 520561 atgattctcg cagctataca aatacaacca aacccaaagt tatagctcgg aatcctcaaa 520621 aaacaaataa ttcgaaatcg aaaacagcca gggctcacaa tgtatccaca tctaataact 520681 ctcccagcac ggacaacgat tccatcagta aatcaactac tgaaccgatt caattgaaca 520741 ataagcacga ccttcatctt aggccagaaa cttactgaat ctacagtaaa tcatactaat 520801 cattctgatg atgaactccc tggacacctc cttctcgatt caggagcatc acgaaccctt 520861 ataagatctg ctcatcacat acactcagca tcatctaatc ctgacataaa cgtagttgat 520921 gctcaaaaaa gaaatatacc aattaacgct attggtgacc tacaatttca cttccaggac 520981 aacaccaaaa catcaataaa ggtattgcac actcctaaca tagcctatga cttactcagt 521041 ttgaatgaat tggctgcagt agatatcaca gcatgcttta ccaaaaacgt cttagaacga 521101 tctgacggca ctgtacttgc acctatcgta aaatatggag acttttactg ggtatctaaa 521161 aagtacttgc ttccatcaaa tatctccgta cccaccatca ataatgtcca tacaagtgaa 521221 agtacacgca aatatcctta tcctttcatt catcgaatgc ttgcgcatgc caatgcacag 521281 acaattcgat actcacttaa aaataacacc atcacgtatt ttaacgaatc agatgtcgac 521341 tggtctagtg ctattgacta tcaatgtcct gattgtttaa tcggcaaaag caccaaacac 521401 agacatatca aaggttcacg actaaaatac caaaattcat acgaaccctt tcaataccta 521461 catactgaca tatttggtcc agttcacaac ctaccaaaga gtgcaccatc ctatttcatc 521521 tcatttactg atgagacaac aaaattccgt tgggtttatc cattacacga ccgtcgcgag 521581 gactctatcc tcgatgtttt tactacgata ctagctttta ttaagaacca gtttcaggcc 521641 agtgtcttgg ttatacaaat ggaccgtggt tctgagtata ctaacagaac tctccataaa 521701 ttccttgaaa aaaatggtat aactccatgc tatacaacca cagcggattc ccgagcacat 521761 ggagtcgctg aacggctcaa ccgtacctta ttagatgact gccgtactca actgcaatgt 521821 agtggtttac cgaaccattt atggttctct gcaatcgaat tttctactat tgtgagaaat 521881 tcactagctt cacctaaaag caaaaaatct gcaagacaac atgctggctt ggcaggactt 521941 gatatcagta ctttgttacc tttcggtcaa cctgttatcg tcaatgatca caaccctaac 522001 tccaaaatac atcctcgtgg catcccaggc tacgctctac atccgtctcg aaactcttat 522061 ggatatatca tctatcttcc atccttaaag aagacagtag atacaactaa ctatgttatt 522121 cttcagggca aggaatccag attagatcaa ttcaattacg acgcactcac tttcgatgaa 522181 gacttaaacc gtttaactgc ttcatatcaa tcgttcattg cgtcaaatga gatccaacaa 522241 tccgatgatc ttaacttcca atctgacatc gaactacatc ctgagcaacc gagaaatgtc 522301 ctttcaaaag ctgtgagtcc aaccgattcc acacctccgt caactcatac tgaagattcg 522361 aaacgtgttt ctaaaaccaa tattcgcgca cccagagaag ttgatcccaa catatctaaa 522421 tctgatatcc ttccatcaaa gaagagatct agcacccccc aaatttccga tatcgagagt 522481 actggttcgg gtggtatgca tagattagat gttcctttac ttgctcccat gtcccaatct 522541 aacacacatg aatcgtcgca caccagtaaa tctaaagatt tcagacactc agactcgtac 522601 agtgacaatg agactaatca tacaaacgta ccaatatcca gtacgggtgg taccaataat 522661 aaaactgttc cgcagacaag cgaacaggag actgagaaaa ggattataca ccgttcacct 522721 tcgatcgata cttcctcatc agaaagtaat tcactacacc acgtcgttcc tatcaaaacg 522781 tcagatacct gtcctaagga gaatacagag gaatctataa ttgctgatct tccacttccc 522841 gatctgcctc cagaacctcc taccaaatta tcagactcct ttaaagaact tccaccgatc 522901 aattctcgtc aaactaattc cagtttgggt ggtattggtg actctaatgc ctatactact 522961 atcaacagta agaaaagatc attagaagat aatgaaactg aaattaaggt atcacgagac 523021 acatggaata ctaagaatat gcgtagttta gaacctccga gatcgaagaa acgaattcac 523081 ctgattgcag ctgtaaaagc agtaaaatca atcaaaccaa tacggacaac cttacgatac 523141 gatgaggcaa tcacctataa taaagatatt aaagaaaaag aaaaatatat cgaggcatac 523201 cacaaagaag tcaatcaact gttgaagatg aaaacttggg acactgacaa atattatgac 523261 agaaaagaaa tagaccctaa aagagtaata aattcaatgt ttatcttcaa caggaaacgt 523321 gacggtactc ataaagctag atttgttgca agaggtgata ttcagcatcc tgacacttac 523381 gactcaggca tgcaatccaa taccgtacat cactatgcat tgatgacatc cctgtcactt 523441 gcattagaca ataactacta tattacacaa ttagacatat cttcggcata tttgtatgca 523501 gacatcaaag aagaattata cataagacct ccaccacatt taggaatgaa tgataagttg 523561 atacgtttga agaaatcact ttatggtttg aaacaaagtg gtgcaaactg gtatgaaacg 523621 atcaaatcat atctgattga acaatgtgat atggaagaag ttcgcggatg gtcatgcgta 523681 tttaagaata gtcaagtaac aatttgctta ttcgttgatg atatgatatt gttcagcaaa 523741 gacttaaatg caaataagaa aatcataaca acactcaaga aacaatacga tacaaagata 523801 ataaatctgg gtgaaagtga taacgaaatt cagtacgaca tacttggatt agagatcaaa 523861 tatcaaagaa gcaagtacat gaaattaggt atggaaaaat ctttgacaga aaaattaccc 523921 aaactaaacg ttcatttaaa tccaaaagga aaaaaactta gcgctccagg tcaaccaggt 523981 ctttatatag accaggatga actagaaata gatgaagatg aatacaaaga gaaggtacat 524041 gaaatgcaaa agttgattgg tctagcttca tatgttggat ataaatttag atttgactta 524101 ctatactaca tcaacacact tgctcaacat atactattcc cctctaggca agttttagac 524161 atgacatatg agttaataca attcatgtgg gacactagag ataaacaact gatatggcac 524221 aaaaacaaac ctaccaagcc agataataaa ctagtcgcaa taagcgatgc ttcatatggt 524281 aaccaaccat attacaagtc acaaattggt aacattttcc tactcaacgg aaaagtgatt 524341 ggaggaaagt cgacaaaggc ttcgttaaca tgcacttcaa ctacagaagc agaaatacac 524401 gcagtcagtg aagctattcc gctattgaat aacctcagtc accttgtgca agaacttaac 524461 aagaaaccaa ttattaaagg cttacttact gatagtagat caacgatcag tataattaag 524521 tctacaaatg aagagaaatt tagaaacaga ttttttggca caaaggcaat gagacttaga 524581 gatgaagtat caggtaataa tttatacgta tactacatcg agaccaagaa gaacattgct 524641 gatgtgatga caaaacctct tccgataaaa acatttaaac tattaactaa caaatggatt 524701 cattagatct attacattat gggtggtatg ttggaataaa aatcaactat catctactaa 524761 ctagtattta cgttactagt atattatcat atacggtgtt agaagatgac gcaaatgatg 524821 agaaatagtc atctaaatta gtggaagctg aaacgcaagg attgataatg taataggatc 524881 aatgaatatt aacatataaa acgatgataa taatatttat agaattgtgt agaattacag 524941 atttcctttt atggattcct aaatcctcga ggagaacttc tagtatattc tgtataccta 525001 atattatagc ctttatcaac aatggaatcc caacaattat ctcaacattc acccatttct 525061 caaaactatc acggaatact aatcgaagac tagtgacgca cgttacgcta tagcaacaac 525121 gtcacaagga taacgttagt agttttttgg aaggacaatt gcaaactata tgtaaacgaa 525181 cgaagacaca cagtccaaag ctgtaacaac aaccacatat ataaatggta gtcttctagg 525241 aaacttcact gtaagattag atacgtagag gtgaaagaca agttgaagtt tggatcggaa 525301 gttccattaa tatttgggta agtaagttcg ccgcgcggca gaaacggtga gtacttactc 525361 acttttgttc taactacaac aaaaaactgt aaaagtggtg taaggtttac gttccgtttt 525421 ggttgcaaat catcagccct ggtttaagct ttatgtccaa cattggttag cgaaggcacc 525481 gtactggtct cgatgtcggt gagcaggggc ggcgaaattc attccaatct tggataatat 525541 atatgtatat atctatacac gcggcgagat cttgtcctct aatttccctt cgctaaatca 525601 ttaagaggtc attcatgaag ttaattcagc accaaagttg gactgttaga cacgagatac 525661 acattgcagt ccaaatgtgc agatttttca gataattgtc gtcgcacaag actgcccctc 525721 ccgtcctcag acagacacaa aattagattt tacgtttaca taaagatgta cataacttga 525781 aaaaacgtta atccctctta aatttagacc ttgtaagtct tcctggccac tctttgtgat 525841 atattgtagt gcaatatatt gattcgttct tcttatttct ttgttcttag gcatttccgc 525901 tttagaaaat tcgttgggtg gtttctgcga cgggtatccc cttcgatttt gcataatgat 525961 cttcaattct acaactaaaa tcaagtagat acaggaaaat attccataaa ttatagtgta 526021 aatcgccctg tatacacctt atcgtttcat ctcaggcaag ttaaagcatt tgggaaacgt 526081 gctagatgac agaagaagat agaaagctca ctgtagagac agaaacagtt gaggcacccg 526141 tggcaaataa tcttttattg tcgaataaca gtaatgtagt agcacctaat ccttctattc 526201 cctctgcctc cacatctacc tctccgctac acagggaaat agttgatgat tctgtcgcta 526261 ctgctaacac caccagcaac gttgtacagc ataatttgcc caccatagat aacaatttaa 526321 tggattccga tgccacgtca cataatcaag atcattggca ttcagacata aacagggcag 526381 gaacatcaat gtcaacgagt gatatcccaa cagatttaca tttagaacat atcggctctg 526441 tttcatcaac taataataat agtaacaatg ccctaatcaa ccacaaccct ctgtcatctc 526501 atctttccaa tccgtcatct tcattacgaa acaagaagag ctctttgttg gtagcttcta 526561 accctgcgtt tgcttcagat gttgaactct cgaagaagaa acctgccgtc atctccaata 526621 atatgcctac aagtaacatt gccctttatc aaacagcgag atcggcgaat attcatggtc 526681 catcatcaac ttccgcatct aaagcgttca gaaaggcttc ggccttctcc aataacacgg 526741 cacccagcac tagtaataac atcggctcga atacacctcc agctcctctt ttacctctac 526801 cttcactatc acaacaaaat aagccaaaaa taatagagag gcccacaatg cacgtcacta 526861 attcaagaga aatactttta ggtgaaaacc tgttagatga tacaaaggcg aagaatgctc 526921 ccgcgaattc aaccacacac gataatggtc cagtagcaaa tgatgggctg cgtataccga 526981 atcactcgaa cgcagatgat aatgaaaata acaacaaaat gaagaagaat aaaaacatta 527041 atagtgggaa aaatgaacgt aatgatgaca ccagcaaaat atgcactaca tctactaaaa 527101 cagcgccttc aaccgcacct ttgggcagta cagacaatac tcaggctctc actgctagtg 527161 tctccagcag taatgctgac aatcacaata ataacaagaa gaaaaccagc agcaacaaca 527221 acggcaataa cagtaatagt gcatccaata aaaccaatgc cgatatcaag aattctaacg 527281 ccgacttgag cgcttctacc tctaacaata atgcaataaa tgacgactca catgagagta 527341 attcagaaaa accaacaaag gcggattttt tcgctgcaag gctggctaca gctgtaggtg 527401 aaaatgaaat tagtgattct gaggaaacat ttgtttatga atcggcagct aattcgacta 527461 aaaacctaat atttcctgac tcctccagcc agcagcagca gcagcaacag caacctccaa 527521 aacaacagca acagcaacaa aatcatggaa taacctcaaa gataagcgcc ccattgctaa 527581 acaataacaa aaaattatta agccgactga aaaattcaag acatattagc actggtgcca 527641 tattgaataa cacaatcgcg actataagca caaatccgaa cttgaattct aatgtgatgc 527701 agaacaataa caatctgatg tcgggacaca atcacctgga cgagttgagc agtataaaac 527761 aggagccacc gcatcaattg cagcagcagc aaccaccaat ggatgtacaa tcggtagatt 527821 cgtatacctc tgacaaccca gacagcaatg ttattgccaa gtcgcctgat aagaggtcaa 527881 gcttagtatc cctatctaaa gtttctccac atttactttc atccacatca agcaacggta 527941 acacaatatc gtgtcccaat gttgccacaa attcgcagga attggaacca aacaatgata 528001 tttcaacgaa gaaatctctt tccaattcta ctttgagaca ttcctctgct aatagaaatt 528061 ctaattatgg tgacaacaaa aggcctctta gaacaacagt gtcaaagata tttgattcaa 528121 accctaatgg agctccttta cggagatact ctggggtacc ggatcacgtt aatctagaag 528181 attacatcga acagccgcat aattatccaa caatgcaaaa tagtgtgaaa aaggatgaat 528241 tttataacag caggaacaat aagtttcccc atggtttaaa cttttatggt gataacaatg 528301 ttattgaaga ggaaaataat ggtgactcgt ctaatgtaaa tcgaccgcaa cacactaacc 528361 ttcagcatga gtttattcca gaagataacg aaagtgatga aaacgatatt cactccatgt 528421 tttattataa tcataagaac gatttagaaa caaaaccgct aatatccgat tatggtgaag 528481 atgaagacgt agatgattat gatcgcccaa atgctacttt caacagttac tatggctcag 528541 catccaacac gcacgaactt ccattacatg gaaggatgcc ttcaagatca aataatgatt 528601 actacgattt tatggttggc aacaatactg gcaataacaa ccaattgaat gaatataccc 528661 ccttaagaat gaaacgtggt caaagacacc tatcaagaac aaacaatagc ataatgaatg 528721 gtagcatcca tatgaatggt aacgatgacg ttacccattc caatatcaat aataacgata 528781 ttgttggtta ctcaccgcac aacttttact caaggaagtc cccatttgtg aaagtaaaga 528841 attttcttta tcttgcattt gttatatcat cactattgat gacaggattc attctgggat 528901 ttttattggc cactaataaa gaactacaag atgtagacgt ggtagtgatg gataatgtga 528961 tttcaagttc ggacgagttg atcttcgaca tcacagtaag tgcttttaat ccaggattct 529021 tcagtataag cgtttcccaa gtcgatttgg acatttttgc aaaaagttct tacctgaagt 529081 gcgattctaa tggtgactgt acagtaatgg aacaggaacg gaaaatttta caaataacga 529141 caaatctttc gttagttgaa gagagtgcta ataatgatat tagtggtggg aacatagaga 529201 cggtattact aggaaccgct aaaaaactag agacaccatt aaagttccag ggcggcgcat 529261 ttaataggaa ctacgatgtg tcagtctcga gtgtcaagct tttaagtcct gggtctcgtg 529321 aagccaagca cgaaaacgac gatgatgacg atgatgatgg cgacgatggt gacgatgaaa 529381 acaatactaa tgaaagacaa tacaaaagca aaccaaatgc tagagatgac aaagaagatg 529441 atactaaaaa atggaagcta ctaatcaagc atgattacga attgatagtc cgtggaagca 529501 tgaagtatga ggtgcccttt ttcaatacgc aaaaatctac ggctattcaa aaggattcca 529561 tggtccatcc tggtaagaag tgagtgttaa gaatgtagct ttttcgtcaa agctgggtat 529621 ttttcttttt atagcgcagg agcggaaggc aatttccaaa acaggaatgt actttccaaa 529681 aaaggaaaat gtagtttgtt ttttgatgtt tttttctctt tgactatttc aaatttagaa 529741 gtgaaaaaat acaaaaatgt tacataggat tcgatacagt gtaatatatc attattatta 529801 cttttaaata aagcgtttag taaacaagag tgagggttat gcaactcgtt tagtaaacat 529861 tctttttttt ttcttcattt aagtataaga caacaatagt agcggaagcg atagtaatac 529921 atttggtagc gataagtgca catgcaattt cactcagata agcagcattt ggacagtaaa 529981 accgacatcg atttcaagcc aaactcaccg cgttccttac aaaataggaa taccaaaaat 530041 ttatctttag atatagcagc actccatcca ttaatggaat tctcatcgcc aagccaagat 530101 gtgccaggtt cagtaaaatt cccatcgccg acacctttga atctatttat gaagcccaaa 530161 cctattgtgt tggagaaatg tccaccaaaa gtaagtccaa ggccaacgcc accatcgctg 530221 tcgatgaggc gaagcgaggc ctctatatac acactaccaa catctttgaa gaaccgaact 530281 gtttctccaa gcgtgtatac aaaatcatcc acagtatcgt ctatcagtaa gctgtcatca 530341 tcatcaccgt tatcgtcatt ttcagaaaaa cctcatctga atagagtcca ttcattatcc 530401 gtgaaaacta aagacttgaa gttgaaggga attagaggac gttctcaaac gatctcaggg 530461 ttagagacat ccacgccaat ttctagtact cgtgaaggta ctttagatag tacggatgtc 530521 aacagatttt ctaaccaaaa gaatatgcaa acaacattga ttttcccgga ggaggactcg 530581 gatctgaata ttgatatggt gcatgcagag atttatcaac gaacggttta tttagatgga 530641 ccattgctgg tactgccgcc taatttgtat ctatattcag aacccaaact agaagatata 530701 ttatcgtttg atttagtcat taatgttgcc aaagaaatac cgaacctgga gtttttaata 530761 ccgccggaaa tggcacataa aataaaatat taccatattg aatggacaca cacatccaag 530821 atcgtcaagg acttatcccg attgacacgc attatacata ccgctcattc gcaaggcaag 530881 aaaatactcg tacactgtca gtgtggagta tcaagatcgg cgtcattgat tgtggcgtat 530941 atcatgcgat attatggctt gagtttaaat gatgcataca ataagctgaa aggtgttgct 531001 aaggatataa gtccaaacat gggtctcatc ttccaactta tggaatgggg aaccatgttg 531061 tccaagaact caccgggcga agaaggagag actgttcaca tgcctgagga agatgacatc 531121 ggaaacaacg aagtttcctc gactacgaag tcctactctt ctgcgtcctt tagaagtttt 531181 cccatggtaa cgaatctatc atcgtcgccg aatgacagtt ctgtcaattc ttcggaagta 531241 acgccaagaa ctcctgctac gttgactgga gcaaggaccg cactggccac agaacgcggg 531301 gaagatgatg agcactgtaa aagtttgtct caacccgcag attcactgga agcttctgtg 531361 gacaacgaat caatatctac tgccccggaa cagatgatgt ttcttcctta agggacagca 531421 tctcccaaaa gaatctttat gactatcaga tctgcaggca gaccgcctcc ctacgcttct 531481 aaatagaatg tacttagcac ttctgcctac atagtaatta ttcatcattg taagtgtcac 531541 attgcaaaaa tcgtccaata gacgttttcc tcgtttgtga ttggccctac gttttgcgcc 531601 gatacaagcg gcggcgaaaa gttaaaaaga acaatcaatt aaataagaac catcagtcct 531661 cgtattttgt cttctgtttg caagcaatgc accaaacaca agatcaacta agaacgcatc 531721 tacaatgtta cgtaacactt ttactagagc tggtggacta tcacgtatta catccgtaag 531781 attcgctcaa acacatgctc tttccaacgc tgctgtaatg gatctgcaat ccagatggga 531841 gaacatgccc tccactgagc agcaggatat tgtcagtaag ttgagtgaac gtcaaaaatt 531901 accatgggca cagcttactg agcctgaaaa gcaagctgtg tggtacattt cttacggaga 531961 atggggccca agaagacctg tattgaataa gggtgattcc agttttattg ccaaaggtgt 532021 tgctgcaggc ctactatttt cagtgggact ttttgctgtc gtcaggatgg cgggtggcca 532081 agacgcaaag accatgaata aggagtggca gctaaagagt gacgaatatt tgaagtcgaa 532141 gaatgctaat ccttggggtg gttattctca ggtccaatct aaatgaacag gccagaaatt 532201 ttgaaaggaa atcaataggg gttaacgatt gtcatggttt tttcagctag tctgtgacct 532261 gtacgaaagt gaatatctta ttacattata agtgtatcca tgggcatccg cccaatacaa 532321 tgccaacata tcaaacataa aattggctga ttgccactct cacatttttt ctttatttat 532381 ttactcaaat tttgtaattt tttgttagac atataatttt atatcattat tcttattatt 532441 cttatattta agggaacccc cctggaatga aataagctaa tatagtatga gggaatcctg 532501 tataaatggg tttaccttgt tattctatgc ctccctttca aagacgtatt tcttaaaaac 532561 ttctccattt ggttgaatac tatgaaaaaa aaaaaatcaa ctagaataga tatggaagat 532621 aaaaatgtgt aacaaaaaag aagaaaagag ctggaggtat gacaatagcg ccaatggcaa 532681 acgatttaga agattttgag tctctgctgg agcctgattt tgatgctaaa caatttggta 532741 atgacttact gaaggctact aataacaatg acacaaccat tttagacctt aacacgcctc 532801 ttaaaaagct aaactatgat ctacatgaga ttgactctag aatagaccaa ttgatgaata 532861 gcaacccatt ggagataata gagttaattt acaaaaatga acacgtcaat tcaaccatag 532921 ttggtgagtt gaaaccaagt ttgggatata tgaatatgtc gtacgataga ctaaagaatc 532981 aagttctaga tccttatgaa agagcgagga aagtccaact agcgttgagt aaagtttacc 533041 aaacatcttt tctcttgcgc ggagcattgc tttatattca tttatcaaac aaattaaacg 533101 cactgtctaa aacagcccaa ctaagcacat caacagctat taatttagcc tccttacact 533161 accaacttga aattactttg gaagaaaata aaaatctaaa atccttgcgg aaaattaaac 533221 aattagatca ggacattgtt tcccccaaca aaagagagtt aataacattt ttgtctttac 533281 aaatgtgtaa agagtgcttg aactctatta aaatcaaatc gaacaaagaa ataatatctc 533341 agctggccta ctccttatat ctactttcat ctcaagaatt cgagtctgca ataaacaaga 533401 ttgtactatc taatgttaca atgagctcac aaatcctatc aaaaatttta aattctatca 533461 ggatgtttcc tgatgcgttc aatgaagttg ttgaaaaagg ttataacatc tacattttag 533521 aaacactact acagaacatc aaaacggata atgttacgaa ttcctcgaga tctattgctg 533581 ctaataaatc acgccttggc aatcttttat cagaatatac ctcaatgaag agtaaagcag 533641 gttctggtac accgagagat ctgttttgga gcaaagtttc atctgccttc aaaaaggact 533701 ttgatatatc tgttaataga ggaggccctg tgggcaagtc gctgttaaaa aataaagatt 533761 ttattataaa cactatgaag caaagtatga aaaaatcttc tgataatagt gattaccaaa 533821 gctacttgga tgtaatgcta aactcagtat ctatttctct aaataagtga gacagtttac 533881 ataaaattaa gaatgttgat gaaataggat gaatctaaag caattttcaa tagcatgtgc 533941 atatgtttaa taaaaattac atgaaatgta atatttgttt atattattaa agattatact 534001 agtaatagtt attatgagaa atccaatatc ggttagttta tatgaagtat taatatgtat 534061 atatatacat ttacgtggtc attctgtcct aaacttaggg gtactgccag cttttgccag 534121 tgggttcaaa ggtacctttt ttttgttttt ctttccacca cgcttatgaa actttttctt 534181 caactgtttc tttatctcac gagctttggt atcacgctcc ttggttcttt caagtgccag 534241 ttttttggct gcacgttgct tttgaccagg tctcctcttt ttaatcttca attccttctg 534301 ctgctctaac tctattctcg cattgtgctt atacagatct attattcgac cctggcaata 534361 tggccattta tcacgaatac gtagatcatc ctccagaatt tttgtacttt cttgtattat 534421 cacatcatag tcgatagagc tctgttggaa ttgcagcttt tggtctgcag aatagcttgc 534481 aaagtagtag tctttgggcc tttcttggtt gattatttct tcttcaggtt ccttcaatga 534541 aattttcatc aaacttactt cagtctgtgg cgtatccttc tcttgagttg atgaaccttg 534601 ttcttcttga gctgggctag tcgatgcttc aaccacacca aacgaaaata acgggaactc 534661 gaattcttct tgtttttctt ccttttgttc atgtgcgctg ttattacttt ctttgagatc 534721 taatgatgag tcggttcttt caacttcaac gaattcaaat tctgttggcg gtactaatac 534781 ctctacatgc tcactattat ttttactact actattggaa tcataatctt ctcctaatcc 534841 ctctccttca ttataaagat cttttcttga tactctgcaa aataattaga atattaaacg 534901 attcgttgaa aagttagtaa aaaaatgaaa ttagaggcaa acttgtatct tatgtcaaag 534961 catacatctt aaattcagac atttttatac tgaatttcaa tgtttttctt tttttttcat 535021 tagaggagat ttttccattg ctgtttaaat gaaactggtc gtattttaag tacttcaaat 535081 ttttcttttt cgtactgatc cgatgacttg aaaatactta ttttttatgt aggaacagaa 535141 tggcattttt gaagtacata actctcacac gcaaaggcca aaatctttca cgatttactt 535201 ttatttctat ctgtattgta tatcaaaatc tatacatgat gatcggttaa taaagataaa 535261 gattaaagaa agactgattg ttatctgttg atactagtct tcatactctg taagtattct 535321 ctataactag cacaatttaa aactttgtct tcgacaagag tacttaatac ccatagcctt 535381 aaagaagcca tatctttttc ggagtttagg ttggcgggct cgttaataga tggtcctctt 535441 attatgtata atgattgaaa tgtgattgta tcattgtttt ctctaattct accgattatc 535501 ctccttagtc tttcattgaa aggcgaatcg ttcaaaagag gcagttcact tttccccaca 535561 ggaatttgag atatggtgtc agtattgaat acatctatta gtaactcagg aacagcatct 535621 ccgccaaccc ataaaaataa ttctgcggaa ttgtcaatta aatacaggcc atatctttcg 535681 aaaagagata tagtggcatt tataggttca ggaagaaccg tttttccttc aaagtcaggt 535741 agaccgactt cgtcgggcat gtcgtgcagg gagtaaactg tagggtaaat gctctttatc 535801 aaataatgaa gaggctccgt ttccaatcta ttcaacgcac ttgcacggta atcgcttgga 535861 acaacgcccg gtctgagggc tatatgttta cttagtccat tcattaatag aggtaacatt 535921 ctcaaatttg cgcataggtt aagtgaggtt actgaattta tattagacat cgaaatttct 535981 tttttgtagg catttaaaat atcttcgagc gattttgtga taaaatccct cgcagagtac 536041 atgcttgaat tcaaagcctt agtcaccgcg ttttgtgtca tgaaatcagt aatggctagt 536101 tgatctgcgg atgcaaacac ttccctagct gattcggacg ttggtagagc taacgtcatg 536161 actctaattc tacgttcacc agtgtttaga gtcaacaatg ttgacacttg caagtagcaa 536221 tattctgcca ttaatgagtc ttcgatggat atcccgaaaa gataagactg atctctaggc 536281 attgtggaaa aagcgcataa atcagaggat ctgttaaaaa aatggccaaa aaacgatgtg 536341 gccctcaagc cagtagaaca acgaactctc ataacagctt ccattgaaat atccatggat 536401 aaatgccttg ataattccct agtaaactta gtaacatcgt tcaaactggt ggcattaaaa 536461 ccaggataaa aatgtgtttg accaccagaa aaacggccca ggtgagatag agtggcaacg 536521 tccatgtagt cctctgatgc cagaaacatg tccactgtta tttgtagttt attacactca 536581 attgtgaatg ttttataaaa ggaatcttta cacgacagta gctgagagct ttcttttggt 536641 gtgtttaata tgccctgttc acttcttttt ttcaatttcc cgatgccagt atttggtaaa 536701 gttgatgaaa tgacttcaac tttgcctcca gtgcttttta tcaaatttga cgcagctttt 536761 agggcaggtc caagtgcaaa cttgctactg tgtgtgtctt gaaaaatttc aggtatcttt 536821 ttcaacaatg tttccagatt atttttacaa tattttagtg gaactactaa ttcatcactc 536881 ggcattggta aaaatggttc atccaaatcg ccaatatcaa acatttgaat tgtttctgaa 536941 ttatcaacgt cttcctcttc ctcgtcttca tcttcttctt caccatctga ttcttcatca 537001 tcctcatccg atacttcata atcatcatcc aaaggaacgt aaaaataatg aaggctatga 537061 tcaacacata taatagcaat tctggtcctt ccatcatgat ttggtagaaa ttctatgttt 537121 tctaaaatgg ttctggcaga agtagccaat aaaccatttt tgacagcgtt ttgagaaaca 537181 tctaaaagaa atacataaac agatggtggg ggttccctaa cagaatattc tacgggagcc 537241 aagtaatcca cgacagagtt tttaatttcg tttctttcat atctgttgat tggagcgcct 537301 tgtaagttct gatcaaaccc aaatgggaca tcatttttga aacggcatat attacattgc 537361 cattttctcc cttggttaat gaaaacgaca aaagggttca tatatgaacg acaacggcga 537421 cagcggacaa tgactccgtc agtatttagc ggtacttggt tgtctgaatc ttgcaaatgc 537481 aaatatggtc taataacaat ggcaaatggt aacttcgttt tcttcagcag agagtttgtt 537541 tttggcaccg ctttcaaagt agatctgacg tactggtatg gaacatttga atattcggat 537601 ggagtcacaa tgttatcctg agaaatggtg attggaagag gtggtaaaga caggtcacgg 537661 attggcggag gtaattctgt aaacaaatcc acagggtata gttgattgac cactttccca 537721 gaaccaggaa actgttgatt ttgagctagc tgtgtaaatg agttagccct attgttcaat 537781 tgtaggttgc ccattgcata agctgtttgg tcgatttgtt gttgagactg ctgttgctct 537841 gcaactattg gcatacttgc aatgtatggc acctgagctt gagggtacac cctcttctta 537901 tgatgagaca ttattcactg cagctgtcga tcattaatgg aagaaggttc atcaaccaag 537961 cacactgcaa atgaagggtt agatgaagag ttcgacgaag acccttttaa ctgacgtatc 538021 attcatcgtt gtcatcgcta catctatgtc cttcgggtaa gctaaacaaa aagtgaaaag 538081 ttcaataaat aataagattg agaggtaagt gaagtgaaga tagatgttag tatccaagtg 538141 tgaccaacat gttcaggtga ttgcaggcga aaatgggcag tgcttggaca aactacaatt 538201 ttgaagaggt taagtctcat tttgggttca aaaaatatgt tgtatcatct ttagtactag 538261 tgtatggact aattaaggtt ctcacgtgga tcttccgtca atgggtgtat tccagcttga 538321 atccgttctc caaaaaatct tcattactga acagagcagt tgcctcctgt ggtgagaaga 538381 atgtgaaagt ttttggtttt tttcatccgt attgtaatgc tggtggtggt ggggaaaaag 538441 tgctctggaa agctgtagat atcactttga gaaaagatgc taagaacgtt attgtcattt 538501 attcagggga ttttgtgaat ggagagaatg ttactccgga gaatattcta aataatgtga 538561 aagcgaagtt cgattacgac ttggattcgg atagaatatt tttcatttca ttgaagctaa 538621 gatacttggt ggattcttca acatggaagc atttcacgtt gattggacaa gcaattggat 538681 caatgattct cgcatttgaa tccattattc agtgtccacc tgatatatgg attgatacaa 538741 tggggtaccc tttcagctat cctattattg ctaggttttt gaggagaatt cctatcgtca 538801 catatacgca ttatccgata atgtcaaaag acatgttaaa taagctgttc aaaatgccca 538861 agaagggtat caaagtttac ggtaaaatat tatactggaa agtttttatg ttaatttatc 538921 aatccattgg ttctaaaatt gatattgtaa tcacaaactc aacatggaca aataaccaca 538981 taaagcaaat ttggcaatcc aatacgtgta aaattatata tcctccatgc tctactgaga 539041 aattagtaga ttggaagcaa aagtttggta ctgcaaaggg tgagagatta aatcaagcaa 539101 ttgtgttggc acaatttcgt cctgagaaac gtcataagtt aatcattgag tcctttgcaa 539161 ctttcttgaa aaatttaccg gattctgtat cgccaattaa attgataatg gcggggtcca 539221 ctagatccaa gcaagatgaa aattatgtta aaagtttaca agactggtca gaaaatgtat 539281 taaaaattcc taaacatttg atatcattcg aaaaaaatct gcccttcgat aagattgaaa 539341 tattactaaa caaatctact ttcggtgtta atgccatgtg gaatgagcac tttggaattg 539401 cagttgtaga gtatatggct tccggtttga tccccatagt tcatgcctcg gcgggcccat 539461 tgttagatat agttactcca tgggatgcca acgggaatat cggaaaagct ccaccacaat 539521 gggagttaca aaagaaatat tttgcaaaac tcgaagatga tggtgaaact actggatttt 539581 tctttaaaga gccgagtgat cctgattata acacaaccaa agatcctctg agatacccta 539641 atttgtccga ccttttctta caaattacga aactggacta tgactgccta agggtgatgg 539701 gcgcaagaaa ccagcagtat tcattgtata aattctctga tttgaagttt gataaagatt 539761 gggaaaactt tgtactgaat cctatttgta aattattaga agaggaggaa aggggctgat 539821 gttttttgaa aatagaagcc ttgtttatga gaaaacttat acataatatt acatacaaac 539881 tagagcatta ctatataatt aacttacttg tcacagctga ttgctttttc taggggaatc 539941 tacattttca atgtaaaatt caggaaccct attctgaatt tgtgaatcat tcgtttccgg 540001 tatcgatgac gtggtgttag tgattgtcaa attgtctaat tttggaatgg aattcaaggg 540061 aaaattgcta ctactcacat catcgtatct cgtatgttgc tcattagtta cctggggggt 540121 cacgctctcc gtggtgtttt cattactctt ggctttttct ttagacagtt tggcaacttt 540181 actcacatat ttgcatttgt cgtcatagtt gggcaaactt gataaggctt tgatatttcc 540241 aaaccattct atcatatcgt cataagagtc tactttgaat acccagttgt gacccctatg 540301 tattagtccg ttagaattcg tacgcaatat aaacttgttc ttgccctgct ctgagttgga 540361 tttcgtcttt ttggaatgct cagtgacagt acattccact aatggtattg acattaacgg 540421 tgtggaaaat ttatgcttat ctggtgtctt aaattcatgt aaaaagcttg gagtgaggac 540481 ataaaaccca cgtgagtatg actttaaaaa ttttgatctt ttctccagaa acccagattt 540541 aacttcaaaa gtaaaaggat cgttttgatt gctatacgag atctctttaa acctcctcat 540601 gggtaaattt ggaggcacaa aattggaaat attccttaga atgaaactat cccattcaag 540661 attcgtgttt ttgttcagta tcgtggaatc taatttagag ataactgagt caaatacaac 540721 ttgggcttct ttgccaagaa ttctagcgta gctggtcaat ccgttctgta tttccattac 540781 aataacactt tctaactggg cccctgaatt ctgcaagtta tcgaatgcct cgtgcaaata 540841 attttcttcc accaactgtc ttttgatttg cttttccaat tgcaatttta tcaaaaatgg 540901 gtcactcttt ggtgtaccta atttacattc ttttaatgat tcattaaaaa gcttcatcaa 540961 gtgtttagtt tgctgaagct ctttgttaca ggaattttta aaatcagatt gcaaagcctt 541021 aatttcttta atcttgacta gtaaatctct tctcaaatcc tctagcctgg gtataatttc 541081 actggtcaac tccttggaac ttttcgatgc caaagaggcc agattatcat gatacttggt 541141 cagcatcgtg ggcaaatctt gaacggatcc acttcctaag ggcagaaaaa atttctgcat 541201 ggacttgtct tcattagaga ccggttgata ttggttttca atgctgaaaa aggggaactg 541261 cacagcatgg gacaacctca gttgctgtct aactatttcg tcctgtattg aggcggtctc 541321 agagagatat accaagatgg cacgaataac atttctccag gcagaaaacc tagcagacaa 541381 gacatcagtg ggctgcgcag aagtcggtat cagtatcgcc agaggggacc taggatcgtt 541441 ttggttagaa tcatactgct tctggtggct atgtaaagac atttttggca gcgttagcat 541501 ggaagggtca gtgaaggaac caacattatt gatattgtta ttattaatat tattattttg 541561 tgatgatgga atattattag agttcaaaga gtgcgtcgta ttggtgccag ccgcagcatc 541621 gactatcgaa ttttgccgat cgtgatcata tacgttcaac tgagccggga tagtgggatc 541681 ggaagtcaca gcgtcgatag ggtaaggtat aggattgcgt tgcgcaagcg acgagggtag 541741 tgacaggggt atgttctggc ctttttgttg ctgctgttga taggcgggat taaaatgttc 541801 tgacctcatt ctgccttcca gttgttgata ttgacttctg aggtcaagag aggctcttgc 541861 actgttccgt tggtaagaca tggtgcaatg gacggctggg taaagcgtat aacgctctcc 541921 taaacctttg cttgcgcggt catcttctca tgtagtaggt tgcatcgcct tttgattaaa 541981 gaatgcggca tgacccggaa aaaagaggca ggtattggct aatgactact accattatga 542041 gtttttacca gtatcagcgc catcattagg aggatatatt agcattggtg gacgtaagag 542101 ctcctaaata tacaagcatc gccgtgatgt gttatatatt gcagctttat cttgctggag 542161 tgtctaccgt atttacttct acttttggca tttttttcgc caatgctggc tcgaacaaga 542221 aactgcctgc catttgaatt attcatatat aaatacacta atcatacgtg agcatagtgt 542281 gacaatttcg gcgcaagata ttaatggagc acgtatcaaa gaggtcaatt gggcaattct 542341 ttaagaggaa aacttcaact gtagatggaa gcaaatcaca gaaatgcgga accactaacc 542401 aactgcggaa gctgctgcat aaaagaaggg tacagaagca ggcagtgccg gttgaatccc 542461 agtacagaat tccgggtgat tttagggata atcaaagcgt gagagtcaaa aactctatgt 542521 acaacagctc accgtcagta acgccatcta cgcatcatat caatgaaagg tatgttcgct 542581 atgacatcaa cacaaggcct ttggttgttg tgctcgcgat ctcaattgta ttttttggct 542641 gtctcctggt cctcaaggac atcatcatcc agtcatcaga aaacatcctg agtgtttcca 542701 aatggaaaat cataggggcc tccttcatgg gtacgcccta cacaggtctt ctcacggggc 542761 tcgttggccc tctcctgtca ccattttcgg ctgtttcgtc gtggctttca ttcatctttt 542821 gacacaatgc gtcttcagtt tccgggggca ttgcgtatgg aaaatcatgt cacttttttt 542881 cttccacttt ttcgtttgac ttatataaac gcactttagt atagtttgct ttatgtatta 542941 ggttatcttg gtgttctaat tgatgttctt gcttccattt gtcattcgtc attccagctc 543001 tatttacctg cccacgcttc gatttcgagg tttacttact gtaatctcaa gaaacataca 543061 catttccacc cctcataaaa tgttgcctct ttcaattgag cagagaagac cttcccgctc 543121 ccccgaatac gatcagtcta ctttatcaaa ttataaggac ttcgcagttc ttcacaccga 543181 tttaaacctg tctgtttcct tcgaaaagtc agccatttca gggagcgtta cattccaatt 543241 gaaaaaactg cacgaaggta aaaataaatc ggatgaatta catctggata catcctattt 543301 ggatgtccag gaggttcata ttgatggttc caaggcagat tttcaaattg agcaaagaaa 543361 ggagccattg ggctccaggt tagtcatcaa taacgcttct tgcaacgata actttacctt 543421 gaatattcaa tttcgtacga ctgacaagtg caccgctttg caatggttga acagcaagca 543481 aaccaagggc ggtaaaccgt acgtgttttc acagttggaa gctattcatg cgaggtcttt 543541 gttcccctgc tttgatactc cctctgtgaa gtctactttc actgcatcta tcgagtcccc 543601 actaccagtg gttttttcag gcatcaggat tgaagataca agcaaggata ctaatattta 543661 cagatttgaa cagaaagtcc ctatcccagc ctacctgatc ggtattgctt ccggtgattt 543721 gtcaagcgct ccaattggac ctcgttccac agtttacact gaaccatttc gtttgaaaga 543781 ttgtcaatgg gaatttgaaa acgatgtaga gaaattcatt caaactgcag agaaaattat 543841 ctttgaatac gagtggggca cttatgatat cttagttaac gtcgattcgt acccttacgg 543901 cggtatggag tctccgaata tgacttttgc tacgcccacc ttgattgcac atgacagatc 543961 caacattgat gtcatcgccc atgaacttgc tcactcatgg tctggtaact tagtgaccaa 544021 ttgttcgtgg aatcattttt ggttgaatga aggttggacc gtttacttag aaagaagaat 544081 tattggtgcc attcatggcg aaccaactag acatttcagt gctctgattg gttggagcga 544141 tttgcagaat tctattgatt ctatgaaaga tcctgaaaga ttttccactt tggtacaaaa 544201 cttgaacgat aacactgacc ctgacgatgc cttttccact gttccgtacg aaaaggggtt 544261 caacttacta tttcacttgg aaactatttt gggtggtaag gctgaatttg atccatttat 544321 tagacactat ttcaagaagt ttgccaaaaa atcattggat actttccagt ttttggatac 544381 tttgtatgag ttctatcccg aaaagaaaga aattttggat tccgttgact gggaaacttg 544441 gctgtataaa ccaggtatgc caccaaggcc tcattttatt acggctttgg ctgataatgt 544501 ttatcaattg gctgacaagt gggtcgaaat ggctcaacat ttgaaaacca cagaggattt 544561 ccggtctgaa tttaacgcta ttgacattaa ggattttaat tcaaatcaat tggttttgtt 544621 cttggaaact ttgacacaaa atggccattc caacaagaaa ccaaaagatt ttgactgggc 544681 caagtttccc gtggcatcta gggcactgtt agatatctat caagataaca ttgttaaatc 544741 acagaacgcg gaagttgttt tcaagatgtt caaatttcag atctttgcca agctgcaaga 544801 agaatataag catttggccg attggttggg aactgtaggt agaatgaagt ttgtccgtcc 544861 cggttacaga ctattaaact ctgtagaccg tcgattggca cttgcaactt tcgacaaatt 544921 caaggacacg tatcatccaa tctgtaaagc tcttgtgaaa caagatttag gtctttgaaa 544981 agggacgtgt cgtaacatga atacgtaaac aattaaatat aacctactaa tgagccttca 545041 ttgctacttc tctggttcta attagtggcg gagttctgtg tcgtgcgata cgaattttgc 545101 acttttgtca catgcaatcg aggcaaaaag aaaaaataaa taataacaac gaatataaat 545161 acaaatcgaa agaattcaga ttgaattcaa tattgcaggg ctttgaacac tgagtttgga 545221 actatcagcc gtcaaatacg cataaaataa catcaaatac tccaataatg aatcagttag 545281 gagctttagc cgtaagttct aaattgtaaa cacatttgca tcattgaaaa actatactaa 545341 cgcgttaacc ttttttctat atttctatag caagtttcac gtttcactca aaacttctcc 545401 atggaaaata ttaagagcga gttccaatcc ttgcaatcta aattagcaac ccttcgcacc 545461 ccgcaagaat ttttcaattt caagaaaatt tccaaacctc aaaactttgg ggaagttcaa 545521 tccagagtgg cgtataacct gaagtacttt tccagtaact atggtttgat tattggttgt 545581 ttgagcattt acacattatt aacaaacttg ttgctactct ttgttattgt tctagtcgta 545641 gctggtattg ttggtataaa caaactaaag ggtgaggagc tcgtaactcc atttggttct 545701 ttcaagacca accaactata caccggactg gtttgtgttg ctgtgccaat aggtttctta 545761 gcttcgccaa tctcaacttt gctatggttg atcggtgctt ctgccgtcag cgttttcgga 545821 catgcatcat tgatggaaaa acccatcgaa actgtatttg atgaagaaac tgtttgaaca 545881 ctcctacaag tgttgggaaa aggagtcatt cttttctatt gtgtatttta ctcttcttca 545941 atatttagtt aattcttgtc ttttattctc tttctccgtc aacattagta tttaattgta 546001 tacagacacc attcataatt gcagttagct tctctgttct ttctcattcc taggatttac 546061 aatgcagtct taccttattt gtttatgttt ttttcgttta tcaagcgtgc aatcaattac 546121 tgaagattca cgtgccaaaa cgtaaaaata ataataacat aacccgagag aggcaagatt 546181 agaatcaatt catcttttca aacaaatggt tatatcgact aagcgaagtg attagatggt 546241 gtacgtcgca gatattcaac agtgacgaat tatatgcgat tgtaagattg attggcaaat 546301 cgtattccat tactactatt aacaactgat ggcatctaga aggtaaaaag ggtcaacgta 546361 gatgaggtag agtttgagct tagggccctg ccgagttttc attagaagac ctctactaca 546421 cttcaaaatg aaatacccct gcatcaccag attcatcaac ctaaacgtac aagacgtatg 546481 aaacacgtat gaaacagttg ttgcgaaaaa aacaagatta agtattttca aagccccggt 546541 tgccttgatg aacctaaacg tataaatagt tgagcaatca gtttagctcc gaagatctat 546601 gcttccaccc tttagtcaga tttagatcct atatagatta tatgggataa gtaacattcc 546661 gtcaatcaag ctgctcttct gacaggtatt aatattgtta agacggctag tattgactaa 546721 cttcatgaca caaccactgt tgtatctcaa aatgagatat gtcagtatga caatacgtca 546781 ccctgaacgt tcataaaaca catatgaaac aaccttataa caaaacgaac aacatgagac 546841 aaaacccgac cttccctagc tgaactaccc aaagtataaa tgcctgaaca attagtttag 546901 atccgagatt ccgcgcttcc accacttagt atgattcata ttttatataa tatataagat 546961 aagtaacatt ccgtgaatta atctgataaa ccgttttgac aactggttac ttccctaaga 547021 ctgtttatat taggattgtc aagacactcc ggtattactc gagcccgtaa tacaacaacc 547081 acacgaaata atcgggcgtg tggtctagtg gtatgattct cgctttgggc gacttcctgc 547141 ctaaacagga agacaaagca tgcgagaggc cctgggttca attcccagct cgccccgtta 547201 tcttttttca ccatcagggc ggaatttttt tgtttagcat caatcaacct aacctctcat 547261 gcttctccaa gctgaaagaa gtaaactcac tctatgtacg tgttgcaaca tatatctgcc 547321 aaaagaatga aagtaggttc agaacaaaca gattgaaagg agaccagtaa aactatatgg 547381 ggggggttgt tcttcccgcc tccttctggg attatgaaga cgcgctgatc tgctatagtt 547441 caacgtcctt ttcgcttact atttctggta agaaatataa ggaattctcg gattaattac 547501 ttttctcgaa aggggattcc gaacacctac cggaaaaaaa tagcagccct taaggggaga 547561 gtacggctct tggcatgacg ggaggcagga cagcactaaa ggcagactag tcactgagcg 547621 ctccaagttg ggtatgatag tatcttcaag ttttggtcga gtagctattc ctcttcttca 547681 aagccactta cgcttcgccc aataatgtca tgatttacaa ataaaccttc ctctccgaac 547741 ccttaaaagt aggcaaattg agaaaatttt ttgctcgtct ttttttctct cgtttcgatt 547801 accttattgg gaacttctcg aagaactcgg cgaagaggtc cagaggaaga ttactgacta 547861 tcatcaagcc ttgtttcttt tggcctcttc agtaagctgc aaatgcagta ttggcttttt 547921 taaaaaagaa aaagagaagg aaagcggaaa ctagtcttgt tgctcttcta gtgcagttgt 547981 tgtttgttca tttgtttctt aataacagtc aacgagaaaa cttgcgcgtg cagtaggaaa 548041 ataagtagca aattacatta catggaaaac ttgcaaccat ctgtgagcac aggcgaccaa 548101 tgagtacttt caacagttac agccagccaa aggaaagcaa tgataatagt cataataatg 548161 tcaacaagag caaatcgctg ttagatataa tatttggtac taatgtatcg gaatgggctt 548221 tttctgagaa tgctttaatg aaagctatgg atttgaaaat agaacaagaa aagactaagc 548281 agcaatatta taaacttgaa aacttgaatc gttcgataga gttgtttaag cttgcttcca 548341 gttcaggtct gcccataaat caaatacata aactattcaa caccgaccat ggcgtaccgg 548401 cgtcttcgcc gatgaaggca gggggcaatc aaccacataa caatacagaa ggcacgcaat 548461 cttcagaaaa tctgcccaga ttgaatggtt ctatgaagtc attaaaacct ctaaatatga 548521 acacagtgtc accaactcca atgagtcgac agccctctcc atataagttt ccagcatcat 548581 cctctaccgg cggtatatca cactccacag ttacaaatgt acaacgaaga gctaattctc 548641 ctgcaagaat aggtgcatcc gcagttgctg cgttgaatga caatatttcc attaaggagg 548701 aagatgtggc taggcgaatt ccctctggta caaaatctca agaatcgcct ttaaacaaga 548761 agccgacttc tcttcacagc cgtaacttgt cacttccaat aggaaagttc accaatccta 548821 atattccttc tacaatgaca tccatactaa gtttcaatag agaccaacag cagccgctat 548881 ctcaaccact gcctcctcct ccacaacagc aacaggatct ccacacgcac aatttacata 548941 ctataccaag gaaacctgga atggttcaaa aaaagcatag gcgtgcaaga tccacatcct 549001 cctttggagt gatcgattta agtattatcg atgaagcaaa agaaaaacaa gtacagagat 549061 caccatcccc tatacattct aacgtgtccg tagcacttac ctcacatgac aaaccaattg 549121 aatccaatat gaaggaacaa ccaaatatgc tgcaatcggt tcgtgaagga cgtcaagtac 549181 acgatgactt ggatgacaga acatgcagtg aaagcagtag tagaaacgaa agccccgtaa 549241 gaaccatcac aaaggataat tctgtaggca agattttaaa tagtacttga gtgatcatta 549301 ttttcttttt gatgttcccc ctacgtatgt atacacccat atattatata gatacccgcc 549361 gcataccaac ataaaaaagg taacaaatat ttgagatata gagcatcgct acattatggg 549421 caagatgcgt ctttgtgaga cgattttaaa cagaagttgt tcatctctca gtgatcaata 549481 cctatcaaca tgtcaaattc atcagtggaa aaatttaaaa tttcgaatac ctgatccttc 549541 ttgttcggat acaaatgaat caacagtttc ctgaagatat tataaaatag cgacaacttc 549601 ttgaaacatt catcgcatat ttcatcagct atcattggtg acgttaattt aaatagtaaa 549661 ttaccttgaa catctgttaa cgcctgaggt agataatagt tcaacttatc atgcacattt 549721 tttctgacca tgtctaattc catcaatgaa ttatccctca gggctaagta catatcataa 549781 tccaattcat cctttactga gtccacagga aaaatcatat tgaccaaatt gctgtaaagg 549841 tctaaacctg tattctcaaa taggaatttt atttgtaaag ttagcatttg cttagtatat 549901 tccttcagtt tatcacaaac ccagatggtg attttccggc tgtcatcatc ttgtgcaaac 549961 aatccctcaa aaggttgaag tctagattta attaaatcga aacagtttat ctctatagtt 550021 agcaatgatg ccttttcttt ttcatttttt ttcgccaaag gaaaagatgt ttgcaattgt 550081 tttaacagaa catcttttat tggttgttct acaattgttt gtaaattctt agatgagagc 550141 aatttattat cttctgattc ctcatcttcg gcagcatgtg tcttttcata aatttcaaat 550201 aactctacca atttattcat atactctgat agccactctg gtggcagtaa atcatctgaa 550261 gaattttttg tttccgccat gactgtttgc ttcatatagt cttcatagta tccaataatt 550321 ctgtttttgg aaatgtcttc caacgacttt aaattgttaa taatagaact atcgtcctga 550381 attccctttc tctcgaacat aactctgtaa agtttcagca gcctcacaat ctcgaaattg 550441 atgatcggat tttcttcaaa cctcacgatt tgctcgatac gaatacgaca cgaattggat 550501 agcgactgga tgatatcgtt cagcaatttg ttgtcgatgc ctttcaagaa tgtcttgttt 550561 tgttgaagta tagaaattgg ggtatctttt aagtcttcat cctgaaagtc aaatagtgac 550621 ttcacgaaat cagcttcatt tgcgatgatg gaatgaacgg acgctagtac gtcaccaata 550681 tacctaattg gatcgtgtgc cgataatatg atgggtttag aggtagttga attcatatcg 550741 aattgagaca aaaactcatc cagaatactc ttggatctca gtgtggtcac tcttttcaac 550801 aactcattaa ataattctag atcacttgac aggaagacca gactcttccg aaaaatgttt 550861 aagctttctt gttcagtagt accatggtca tttaataaat ttgaagagga ttcaaaacta 550921 tataaaaaat cgatcaaata attgaagatt tttttgtttg tcttttctaa aatttcatta 550981 actcccatta tcaaagcatt tccagcattc aaattaggaa gcgtcagcaa gaaacttgat 551041 tcatctttaa tattgattac tttctttact acctcgaaaa agatgttgtc tatagtacca 551101 ttggtgatta catcgtcctc tacctgattc aaagtaaacc tatcccttat agataacagt 551161 attttttttt tcagcttcaa ctgctctgcc tttaaacggt attgatctat ttcctgaagt 551221 accacgttat ttgttggaac ctcatttgtc tcattactta gtaatttttc gctcgttctt 551281 tgtatttttt cgacggaaga agataatcgt ttaatccttc taatgatagg tttgaattcc 551341 tcaagtaccg taatatgttc ctttagcagt tgagattcca aatcagtcct caatgctctt 551401 cttgccaaag tacctacata ttcaggattc atgagctttt gttcatcaag ggacaatctc 551461 tctttattct cttctagaac ctttagggat tttcttagtt ggactgtggc ctgatagtta 551521 atcaatgtgt aattgttcaa tatcttggat agtttattcg aaagaaccaa atttgtggta 551581 tttttgttgg aaccacttga cggggatact aattttgata aatcaaggtt ttttggctcg 551641 taattcgtga aattttgaga ttcttgctgc gatagttttt catcctggga attttgccct 551701 aattgtttgc ttggatttga aagctgtatt ttatcaatgg aagacattgc gtaatgtgtc 551761 attttcttat gtaggtcttt cgaaccagca ccatcattat ctactggcaa agttgcatta 551821 ttattggaat aacgttgaag gtcgggcaac ttaaactgta gatctagttt accggtgggc 551881 tgtgactgtg catctgaggt taagtttagt cttggctcag gttctggtaa ttctggcgtg 551941 gcagtatccg ccattgcgta ggtctgatag tctacaacga aatccattgt gagtaaactt 552001 cactggggat tttgttacga taatgtacaa tatacttcag atactacagc tttcggatga 552061 atatttacta gaatgaatta ctaccttaga tgtatatttt gtatgaaagc gtcattacgc 552121 cagttgtatg tattttgtcg tctgagacgg caggtgatat ataagtaaaa tggaagtata 552181 aacgaacaga aagcaatcat taacaattta cttatagatt tcgactaaca tacgcatcgg 552241 taggattaga taccagtttt tgaaatccaa tttttccctc gtatatggaa tgtgctgaga 552301 gttttcctca gggatatgcg tatcaacaaa agagaggtgg taatacatgc aatcatatag 552361 cggtttgttt ctttaatact atatgttgtc acttataatc ctgttatatt attgatcttt 552421 aggtttcagc tgatccttct aatatccctc tattggtttc gtaattcgtg ttatccttta 552481 agaagatcct agcgacataa tcatactatc aactgttatg ttaccgtttg gtgaacagtt 552541 ggctttttgc tccggcattt ttgattaaaa ataggctctt gttaagctac tggaattttt 552601 ctatattacc aggctactct tgatatggca ccggaatgta ataggagtta caagaccatt 552661 tcaagttaaa gaaaaattac tggaaaaagg gtagtaacgt acgtggacga aataaataag 552721 aaggacgtaa atttaataca aatgcacaag taaagttatc ggctcctatt cttcactaat 552781 tccatgcata ttaagaactg ctggaataag aattgaccgt tgcttattga ctagtggcca 552841 tgttactagt atacctatca cacacaatgt aagaaagtga cataagccat gagatacaat 552901 ctcaaatcta gtaaaagccg aaatacaaga actgatgatg taacagagta atgcataaca 552961 acgtgcaatg caaaggaaga aataatagtg ttattacgta ggacattgat ttcctgtcat 553021 gactattata tcctcaatga gcgcatataa tgcattctgt atattcaata ataccacctt 553081 atcaaataac gaataccatc gattatcagt aaattcatgt atcactcgcg taaattctga 553141 aattcagccc actaggaaga cgtttatatc agtttacttt tgtacaagtg acttattgca 553201 agcaatttgt acgaaatatg cttacacttt tcattagtaa aagaaccaac cacccatcat 553261 taacatcttt ttatttttta tccttatcgt gtaaaaaaaa cttaagaata gacatcctgg 553321 tgacgcatat cgacgaaagc acacaacagc gtcaaaaatt gattaaaagg taagttatca 553381 tgcccacacc tatgacgcct gtcaaggtcg gcgctttagc ctgccagagg aactcatttc 553441 tcttcgatgg gttcaaaaca ctggttgttt cttgcgaacc aacgaagaat aaaaagggag 553501 agattgaagg ttatgagatt gaactacaag atactattct gttccccgaa ggtgggggcc 553561 aaccaagtga ttctggtttt ttgaaaattg ttgaagggaa tcgtaattcg tcgaaaattg 553621 agaagatatt agtttcacac gtttctcgtt tcggtttaca tgcaaagcat catgtcaatg 553681 actacattga gcccggaaca acagtggaag tggccgtgga cgagcaaaag agaatggatt 553741 atatgcaaca acatactggt caacacttgt taagtgccat tctggaacgc aactacaaag 553801 tagacactgt atcttggtcg atgggtggta tcatcacaaa gaaaaaacct gttctagagc 553861 ctagcgacta tttcaattat atagagttga acaggaaatt gactctcgac gaaataacga 553921 acgtatcaga tgagattaat cagttgatca tcaactttcc tcaggaaatt attgtagagg 553981 aaagaatcgg tgaagaaaca gtagatgaag ttagtacatc caaaattcca gacgattacg 554041 acctctccaa aggtgttcta cgtactatcc acatcggtga cattgattct aacccatgtt 554101 gtggtacaca tttgaaatgt acctctcaaa taggttccat tttaattctt tccaatcaat 554161 cagccgtaag aggttcaaac tcaaggctct atttcatgtg tgggaagcgg gtttctttgt 554221 atgcaaaatc tgttaataaa attttactgg attctaaaaa cttattgagt tgttcagaaa 554281 ctcaaatttc tgagaagata acaaggcaaa ccaaacaaat tcaacaatta aataaaagag 554341 aacagtattg gataaagaga ttagcacgta ccgcttctga agaattaatg aacacactga 554401 aagccagtgg aaagaaaagg gcttatttta tggaagaaga atacggaaca ttggaactgt 554461 tgctacagat ccacaaggaa gtatctaatt ttttgaaaga tgatacagaa ggttacgaaa 554521 ttatcctatg cggttatgaa agacaaacga acactggctc actgctaatt ctttcggaat 554581 cgggtgaaaa aattgccaat ttggctgcta acttaggttc gatactacaa aacctaaaag 554641 gcggtggtgg taagaaaggt ggcaagtggc aaggtaaaat tacatccatt tcgaatgccg 554701 agtttgccgc cctctctgat tatttaagcc atgatttcgc atcatgttga gaaatgtgcc 554761 atttgtatac gcagatttgt tgtatacata atggtaggta tttatcgtga tcaagtctca 554821 ggaagtcaat aagcatggtc tattcttttc ttttatgtag tttataatag gcaactttaa 554881 tgttcccaga agacgcgttt tccattactt attataccca aaaaaaaaaa ttaaaaaaaa 554941 acaacttcga acatgcaaac gcaaagcgaa ggaaattata actttgactt ctaacctatt 555001 aaagaaatac aaacaaccgg caaggagcca ctgattacca ggtatttatg agtagtattg 555061 ttaataaaag tggtacacgc tttgccccta aagtaaggca gcgtagagcc gccactggag 555121 gaacaccaac tccaaagcca agaacccctc aacttttcat tcccgaaagt aaagaaatag 555181 aagaagataa tagtgataac gataaaggtg ttgatgaaaa tgaaacggct attgttgaga 555241 aaccttcgct agttggagaa cgctctttag aaggctttac cttaaccggc actaatggac 555301 atgataatga aataggtgat gagggcccca ttgacgcctc gacccagaac cccaaagcag 555361 acgttataga agataatgtg actctaaaac cggcaccctt gcaaacccac cgagaccaga 555421 aggtaccgag atccagcaga ttagcttcac tgagtaagga caacgaaagt cgtccaagtt 555481 ttaaaccgtc atttctcgat tcttccagta acagtaatgg gactgcgcga cgtttatcta 555541 caatctccaa taagcttcct aaaaagataa ggcttggaag cattacagaa aacgatatga 555601 atctgaaaac tttcaaaaga catagggttt tgggcaaacc ttcttcggct aagaaaccag 555661 caggtgcaca cagaatcagt attgtctcca aaatttctcc acctacggca atgaccgatt 555721 ctttggacag gaatgaattt tcgtcagaaa cttctacatc aagagaagct gatgagaatg 555781 aaaattatgt gattagcaaa gtcaaagata tcccgaaaaa agtgagagat ggggagtctg 555841 ctaaatattt tatcgatgaa gagaatttta cgatggcaga gttgtgtaag ccaaactttc 555901 ctattggtca aatatctgaa aactttgaaa aatctaaaat ggcaaaaaag gcaaaattgg 555961 aaaagagaag gcatcttaga gaactcagaa tgcgcgcacg acaagaattt aaaccactac 556021 actcattgac taaagaagaa caggaagaag aagaggagaa gagaaaggaa gaaagagata 556081 aactactcaa cgctgacatt cctgagtcag accgcaaagc acatacggcg atccaactga 556141 agcttaaccc tgatggtact atggcaattg atgaagagac tatggttgtt gacagacaca 556201 aaaatgctag tatcgaaaat gaatataaag aaaaagttga tgaaaaccct tttgccaatc 556261 tttataatta cgggtcgtat ggtaggggtt catacacaga cccgtggact gtggaagaaa 556321 tgataaagtt ctacaaggcg ctttctatgt gggggacaga tttcaatttg atctcacaat 556381 tataccctta tagatcaaga aaacaagtga aggccaaatt cgttaatgag gagaagaaac 556441 gtccaatatt gattgaattg gcccttcgat ctaagctacc gcctaatttt gatgagtatt 556501 gctgcgaaat caagaagaac attggtacag tagcagactt caacgagaaa ctaatcgaat 556561 tacaaaacga gcacaaacat catatgaagg aaatcgaaga agcaaagaat acggcaaagg 556621 aggaagacca aactgcacaa aggctaaatg atgctaattt gaataaaaag ggatctggtg 556681 gtattatgac aaatgatttg aaagtttata gaaaaacgga agttgttctg ggtacaattg 556741 atgacttgaa aaggaagaaa ctcaaagaaa ggaataatga tgacaatgag gataatgaag 556801 gaagtgaaga agagcctgag attgatcaat aagagacatt tatatgcata cataatggat 556861 aaatagcaca actttttgtt gtattatatc attttcttca ggtgtaccgc ggcatcaata 556921 aatgaagcga tgttcggaag aaaaaattgg caacgaaaac agtattatga aagttacata 556981 tgaggatcgt tctataagca aaagaaacaa aaggatgata tgattagtaa agagtatgaa 557041 tttggtaaga ctagtatact gaatagaaag aagtatacat tagttatcga tgaagacaag 557101 aatggcaatt ttataagatt taccgtttta cctgtatcta accgaaagtt caaaaaagtc 557161 aagcaaaatg ggagggtaga gattaacatg ggcatacaat atcaccaaat tgtacttatt 557221 ttactactga atattttgtt ctatgtaatt tgcctaagat caagatttct cgaacatatt 557281 aatagaactt ttgaagtgac aatcgcgcga agtttccaga tcttaattat aatgggattg 557341 tttgccttag gtacaattat acttgtgagg ggacctagtg tggaaactgt aacaattttc 557401 aaagaaagtg gactacagct gtccagagtg aagggtatgg ttatatttcc tcaacaatgg 557461 aatcggaagt tctttgaaca agtagagttt atatccaatg aaagaattat tgatgtagtg 557521 atcaatgaag gattctgtcg gggatttcga gtgatattct atcttgcagc aattgtacgt 557581 aaatcgtcta cgcttaagct attatttcca gtatgtattc aagcgaattt aagattgttt 557641 cttacttcaa cgatctgatt agaaatacta acacaacaat gcagtcaaat ttgcccagta 557701 tcgatgacca acgtctaata tacaacatat ctagaaaata tctcagtaag caagaaaaac 557761 ccctgagcag accaaaagat tgaacatcaa attatcatta cagaaaatct tgagacattt 557821 tggtatatac ttatatttta gtgtatgttt atatataatt atagataaga atttgaacac 557881 acttaagttg cagaacaaaa aaaaggggaa ttgttttcat tacatggtag ataatttgtt 557941 gatgatttca ttcgtgaagt cagtagtaga agaggaacca ccaatatctc tagtggtatg 558001 cttaccttct gcgatcgttt catgaactgc ctttgagatt ctagtagcat attcattcaa 558061 acccaaatgg ttcaacatta acgtggagga aaggatcatg gcagttgggt tagccacatt 558121 ttggccttta atatctaaac caacatgtct ggaacctggt tcgaagacag catagtccct 558181 gccaaagttg gcacctgcca ccaatcctgg accaccgatc aaagcagcgc caatgttgcc 558241 taagatggta ccgtacattg aaggggtaac taggacatca aattgatgag gtttggccac 558301 cgcctgcatg gaggcattgt cgacaatgat ggacgatacg tcaatatcag gatattcttt 558361 ttggccaatt tcagttatta tatttctgaa cagaccgtca cctaacttca tgatatttgc 558421 cttatgcaca gctgtgacag actttctgtt gtatttcttg gcgaagtcaa aggcaaatct 558481 ggcgatcctt tctgtcttag gtctagtcat aactttcaaa gattccacta caccagggac 558541 ggattcatgt tccaggcctg agaactcacc ctccgtgttt tctctaatga caatcaaatc 558601 tatgtctgga attctagtct tgacaccctt caaggatttg aaaagggcca cattggcgta 558661 gatatctagt tgtttacgca aagcaacgtt tagtgaaccg tgacctgttt ggtcagcagg 558721 agtgtgccat agccccttaa gaccaatctt atttctcttt agagactcaa cagcttcata 558781 gacgccttcc ttatgatctg tttgcttaat gtttatagtt tcccagtcga tcgggatatt 558841 ttcagcctca aaaatggttc tcactgaatc agtgatttct ttcccaacac cgtcaccagg 558901 tatcaaagtg acggtgaaac gaccgccata cttcttgggt agggtgcgtt ccgcctgagc 558961 ggcagtggct aaagttctct tagcaattgt tctgttaagc atttttctct tacaattatg 559021 gaggaaaagg gagaagaatg aggataggga gaataatgaa ccttgattgt taccagtaat 559081 attaaggtac tgttgaaata gatctacggt agagtaaaga aatcaatcaa tcaagaataa 559141 gccaatgaag cggaagaaaa caagaaaaaa gacctatgga aaatatagat agtcctatgt 559201 gctcacccac ataaaacact tatatatata ttcagtgtag gcatgtattg tacggggata 559261 tatatatgag ggtcttcctt taatcgctaa ataacaatac cgagctacca aaaaaaataa 559321 aagaaggttt ctgcaatatg gttggttgat gagtgaccta tgacgcccga tgctcggaga 559381 aggtggtcag gcacacgtga ttcacctaaa ctcggcgccg aaaaaaattt gatcagccgt 559441 acagtgtgat tgttatcacg tgatagtaac gtaagtcacg tgctttctaa ccatcacccc 559501 gcacgaacgt tcgttcccgt ttcgatgttg acgtcagaat gagctaactt gacgccactg 559561 aattaattcg cattgtcacc atgacgctta tcaagccgaa aaaattacta gtgattcctt 559621 cctccccctc tctcgatgag taattttgaa atgaacaagt aggctgacat agagtactat 559681 aaatacttag gaagtaatga ttctcgagga taggtaagag ctgtcctctt ctaattcttg 559741 ttcgttttct tctgaaaacc ccaaccacat caactacagc taagactaca aatttcaatt 559801 attacacatc agaatgagcg ctaccgaatc ttcatctata ttcacattga gtcacaactc 559861 aaacctacaa gatatcttgg ccgccaatgc caaatgggcc tcccagatga acaacataca 559921 gccaactttg ttcccagatc acaatgcgaa gggccagtcc cctcacactc ttttcatcgg 559981 ctgctccgat tcgcgttaca acgaaaactg tttaggtgtc ttgcccggcg aagtgttcac 560041 ttggaaaaat gttgctaaca tatgtcactc agaggattta actttgaagg ccactttaga 560101 gtttgccatt atttgtctaa aagttaacaa agttattatt tgtggccaca ctgattgtgg 560161 tggtataaag acatgtttaa ctaaccaaag ggaagcctta ccaaaagtta actgttctca 560221 tctgtacaag tacttagacg atattgacac catgtaccat gaagagtcac aaaatttgat 560281 ccatttgaaa acgcaacgtg aaaaatctca ttacctgtcg cactgtaacg tcaaaaggca 560341 gtttaatagg attattgaaa accctactgt gcaaactgct gtacaaaatg gagaattaca 560401 ggtatacggt ctgctttaca acgtagagga cggtctactg caaacagtta gcacttacac 560461 aaaagttacc ccaaaatagt tttagcctca ccgatatact tatataatat tcattgaaat 560521 agaaagacat ttacaaagta gacggggata tttagcccca ctcatataaa ttatgcatta 560581 taacttttat aaaaaaaaag aaatcacact taaataaatg tcttaattgc acattccatg 560641 ttcagatata cactatctta ccttttgaat aggaatgatg gaaaaaaaat tatgcttcca 560701 atcggatttg aaccgatgat ctccacatta ctagtgtggc gccttaccaa cttggccata 560761 gaagcccgtt attacggtct gtgatccagc aaatgtcaga tataacgaat tgaagttgct 560821 tttcccatca atgtttgtca agttgaaacg ctgtagcaca cactaagcat taacgactat 560881 attacaagta aagcatcaaa tgattactta aaagagtaat cgcaaactat attgaagttg 560941 gcaaaggcac atgatccaaa tggtaacgat aacaacatat atgaaaagta gtgttctagg 561001 aaacttcgat aggggagaaa gtacgtaaaa aaaataattt tgagttggat tcgaagttcc 561061 attaatatct tggataatta agtttgctgc gtgagagaca ggcagattcg gcttcacagg 561121 aataaactcc tataatttaa aggaacttgt tagtgttagc actataagta agaaaaagta 561181 aattctggca gtgttgcttt taatcgcaat aatatttgat ttacattcaa acagtttcat 561241 atacctcttt gatagaacat atttgcatat gtgtttattt gttttttatt tttttttgat 561301 tacttctttt caaaaactaa atgtgaacaa agaagaaaaa ggagtataaa agaataaata 561361 atagcggtat tacgtgtgtt ggaaaaagaa tcatagatcg tcaatggact agtatttgta 561421 ttaccagtat tattataata tggatcgtaa gaagataaca taaaacatag aaacagttgt 561481 caaatccttg cacaattcta acattcatta tcctattaca ttatcaatcc ttgcatttca 561541 actttccatc aaatttaatg atttgttttc aatctttatg tcttcttttt acatcgcata 561601 tgatactgtt ggaacgagag taattaatag taacatgagt tgctatggta acaatctaat 561661 gcttacatcg tatattaatg tacaactcgt atacgtttaa gtgtgattgc gcctattgca 561721 gaaggaatgt taaacgagaa gctcagacaa tactgaagct gtgttaaaga tctattagtt 561781 gaacatgata tggtaggtac atatatgagg aatatgagtc gtcacatcaa tgtatagtaa 561841 ctaccggaat cactattata ttggtcatga ttaatatgac caatcggcgt gtgttttata 561901 tacctctctt atttagtata agaagatcag tactcacttc ttcattaata ctaattttta 561961 acctctaatt atcaacagat accatgctag tattacaaat aatactaaac agatgatgtt 562021 agagtttcat tctgaaaaga atgtggattt tgatgtaatt gttgggattc cattttttat 562081 aaggcaataa tattaggtat gtagatatac tagaagttct cctcgaggat ttaggaatcc 562141 ataaaaggga atctgcaatt ctatacaatt ctataaatat tattatcatc attttatatg 562201 ttaatattca ttgatcctat tacattatca atccttgcgt ttcagcttcc actaatttag 562261 atgactattt ctcatcattt gcgtcatctt ctaacaccgt atatgataat atactagtaa 562321 cgtaaatact agttagtaga tgatagttga tttttattcc aacataccac ccataatgta 562381 atagatctaa tgaatccatt tgttagttaa tagtttaaat gtttttatcg gaagaggttt 562441 tgtcatcaca tcagcaatgt tcttcttggt ctcgatgtag tatacgtata aattattacc 562501 tgatacttca tctctaagtc tcattgcctt tgtgccaaaa aatctgtttc taaatttctc 562561 ttcatttgta gacttaatta tactgatcgt tgatctacta tcagtaagta agcctttaat 562621 aattggtttc ttgttaagtt cttgcacaag gtgactgagg ttattcaata gcggaatagc 562681 ttcactgact gcgtgtattt ctgcttctgt agttgaagtg catgttaacg aagcctttgt 562741 cgactttcct ccaatcactt ttccgttgag taggaaaatg ttaccaattt gtgacttgta 562801 atatggttgg ttaccatatg aagcatcgct tattgcgact agtttattat ctggcttggt 562861 aggtttgttt ttgtgccata ttaattgttt atctctagtg tcccacatga attgtattaa 562921 ctcatatgtc atgtctaaaa cttgcctaga ggggaatagt atatgttgag caagtgtgtt 562981 gatgtagtat agtaagtcaa atctaaattt atatccaaca tatgaagcta gaccaatcaa 563041 cttttgcatt tcatgtactt tctctttgta ttcatcttca tctatttcta gttcatcctg 563101 gtctatataa tgacctggtt gacctggagc tctaagtttc tttccttttg ggttcaaagg 563161 tacgtttagt ttgggtaatt tttctgtcaa ggatttttcc atacctaatt tcatgtactt 563221 gcttctttga tatttgatct ctaatccaag tatgtcgtac tgaatgtcgt tatcactttc 563281 acccagattt attatctttg tatcgtattg tttcttgagt gttgttatga ttttcttatt 563341 tgcatttaag tctttgctga ataatatcat atcatcaacg aataagcaaa ttgttacttg 563401 actattttta aatacgcatg accatccgcg aacttcttgc atgtcgcaac aatttattaa 563461 atatgattta atggtttcat accagtttgc accactttgt ttcaaaccat agagtgattt 563521 tctcaaacgt agtaatttat cattcaaacc taaatgtggt ggaggtctta tgtataattc 563581 ttctttgata tcagcatata agtaagcaga ggatatgtcc agctgtgtga tataatagtc 563641 gttgtctaat gcgattgaca gtgacgtcat cagtgcatag tgatgtacgg tattggattg 563701 catatcagaa tcatatgtat cggggtgttg aatgtcgcct cttgcaacaa atctagcttt 563761 gtgtgtacca tcacgtttct tgttaaatat aaacattgag tttattactt ttttaggatc 563821 tatgtcattt ctatcataat atttgtttgt atcccaagtg ttcattttca atagttggct 563881 aatttcttta tgataagctt caacatatct gtctttttct ttgttgtctt tattataagt 563941 aattgcttca tcatatctta aggtcgttcg aactggtttg atcgatttca ctccttttat 564001 tgctgcaatt aaatttatgc gtttcttcga tcttggtggt tccagacttc tcatattctt 564061 attattccat gtgtctcggg atacctcaat ttcagtttca ttatcttcta atgatctttt 564121 cttacttttg gtagtagtca gaacattaga atcatccata ccacccaaac tggaattagt 564181 ctgacgagag tgtatgtgtg gaatatcttt tgaaacatca gaagtgtccg taggagattg 564241 atgggttaag tcaggaagtg ggaggtcgtc aagaatagaa tcagccgtaa cattttttga 564301 ggatttgtca ggcattatat taggagtcgc atggtcagaa gatcgatatt ctggcggatc 564361 cgtatcaatg gagggtgtat tatcacatac agcctttgtt tctatggaga tgatgggagt 564421 agtggattca ctgttggacg aacggtcatc tattgagggc gtactatttg tagtcctgta 564481 tttgatattt gtatcactat ttcgttgaat atatggttcc tccgtaccac ccaaacgtgt 564541 agttttgatg ttttcaagtc cataattaac tctatcctgt gaggtcaaat caatcatatc 564601 attgggacta ccaggtcgct tttggtttcg tgcagtgaag gtagacgagt gtctaggtga 564661 agtagtatct gattcaacgg taccaaccat ttcggtactc tctttattaa tgatatgggg 564721 tgtacgagat cgtatagtag atggaagaat attgtattca gatatgtcgg catcaacttc 564781 ttttggtgca cgtacttttt ggactggttc cttgtctaat tgtaaagggt ttattgattg 564841 ggacgagaag tcgttcacta gaggatcaga gtttatttca atctccgatt gatagtcatg 564901 atcagattct gtattttgat catatgactg ctccgtttca ttttgttcaa taaaagattg 564961 gttatgggct gttaaacgat tgagatcatc atcaaaagtg agtgtatcgt agtcgaactg 565021 gtccaatttc gtttgcttgt tttgtaatat aacgtaattg gtagtatcta ctgtcttttt 565081 taatgatgga agatagataa tatagccata agagtttcgt gacggatgta aggcgtaacc 565141 tggaatgcca cgaggatgta ttttcgagtc gggattatgg ttgttaacta taaccggttg 565201 accgaaaggt agtatagtag taatgtccag tccagctaaa cctgcatgtt gtcttgcgga 565261 tttatcgttt tttggtgaga ctaatgaatt tctgattata gtagaaaatt cgactgctga 565321 gaaccataga tgatttggta gaccactgca atgaagcagt gtgcgacaat cgtttaataa 565381 agtacgattt aatcgttcag cgacaccgtg tgctctagaa tctgccgtgg ttgtatagca 565441 tgcagtaata cctctgttcg taaagaactt atgaagagtt ttgttagtgt actcggagcc 565501 acgatccatc tggataacta gaacgcgagc attgaattgg ttcttaataa atgctaatat 565561 cgatgtaaaa acattgagga tagattcttc acgacggtcg tgtaatgggt acacccattg 565621 gaatctggtt ttctcatctg taaacgatat aaagtaagaa ggtgcacttt tcggtaagtg 565681 atgtacagga ccaaatatat cggtatgcaa gtactgaaaa ggctcatatg attcttggta 565741 ctttagtcgt gatcctttga catgtctatg tttcgtgctt ttgccgatta gacagtcagg 565801 acattgatat gtgctagcgt tagaccattc aatatccgat tccttcaaat atgtaactgc 565861 attcttctta agagacttct gaatacttcg gaagttagca tgtccaagca ttcgatgtat 565921 taacggatat ggatatttat ttacgctttt gcttttgttg acgttgttta ttgttagctt 565981 tgaaatgtgc gaaggaatta ggtatttttt agataaccag taaaagtctc catgtttgac 566041 tatgggagct agtactgtac catccgatct ttctaaagtg tttctggtaa agcaggcagt 566101 aatattttga ttagccagct cactcaaact taatagatca taggctatgt ttggtgtgtg 566161 tagtgctttt attgatgttt tggtgccgtt ctgaaagttg aagtgaagat taccaatggc 566221 atttatagga atgtcttgtt tttgagcatc gactatgttt atttcagaat tgggtgttgc 566281 atggtgtaaa taatgggctg atctgacaag cgtttgcgaa gctcctgaat caataagaag 566341 gtgatcaggt agttcgtcat tcgagtctac tgtgtgtgtt ggcttagatt ctttctgttg 566401 ctggcctaag actaagttcg ttgtcatcgc ttaagtattg tgatgaaacg gttgattcat 566461 taatgtgatc attgttcacc cttgagaatt tactagatgt agcaatattg tgagcttttg 566521 ctgctcttgg ttttgaacta tttgttctct gataattacg agttgtaacc tttgtgttag 566581 tcgtgtttgg agatgtgcga gaaacatttt tgtattcgct gtgttgtttg tattgggacg 566641 gtttatttag attcatgatt ttattttcgt catatattaa ctgaatttca gcgaataatt 566701 gggaaagttt catgttcgtt ttggtacgat attgattacg taggtatttg aagtcaccgg 566761 atagaccttt aagtattagt tgacaggcca atctgtcgct aacattgata ttgttttctt 566821 ttagcctctg aatgatcgta ctgactgtaa tttcaaatgt atcagcagat gtacttccgt 566881 cgtactcaag gttggcaaga gctatccaat cctttaattc ttgattgtta gtttgcattt 566941 tggacacact tttacaaagg actgtaagga tgtcagcata attaatttct aaaatttgtt 567001 ttacccatgt tggcaataaa tgaaatgggg caaatgcttg gaaggtattg tatatatacg 567061 catgttcttc ataagtcatt tgtcttttga tttcaccctg gtcatttgga atgatgtcac 567121 cgagattaga gttcttcaaa aatctgatgt aaaatttaac ccatgtagaa aagttttctt 567181 ctgatgttaa agtgtgtggt ggtaagacgt tatttcccac ctttgtctta gcttgaggta 567241 tttcagagtg ttgatttttt aaatcgattg gatcaggtga ggaagtactc agtggtggga 567301 tataccgtgg caacggatag tgtgggtccg gttgataata cgcaggtgac gtttgataat 567361 gtgaacacgt catcatagat ggttgttggt aatgtgccca gttagaggcc atagctttgt 567421 ttggggtcat catgccgtgc tgttggtact gtccattctg tggaggtggt actgaagcag 567481 gttgaggaga gacatgatga tggttctctg gaacagctga tgtcccaggt gttgtctctt 567541 gttgagaatt aaccttagtg gaatctctat caaattccgg taaattggaa gctgaaacgg 567601 ctaacggatc ttgatttgat gggacttcct tagaagtaac cgaagcatag gcgctaccat 567661 gaagaaaaat gtggattttg atgtaattgt tgggattcca ttttttataa ggcaataata 567721 ttaggtatgt agatatacta gaagttctcc tcgaggattt aggaatccat aaaagggaat 567781 ctgcaattct atacaattct ataaatatta ttatcatcat tttatatgtt aatattcatt 567841 gatcctatta cattatcaat ccttgcgttt cagcttccac taatttagat gactatttct 567901 catcatttgc gtcatcttct aacaccgtat atgataatat actagtaacg taaatactag 567961 ttagtagatg atagttgatt tttattccaa cacattccaa taccactgat aagtacattc 568021 tgcatgtcta tttataaaac cttctttaag acaaatatgc tatttatcct ttgataacaa 568081 tttcctgtga gacagaaatc accataaaat aatcgggcgt gtggtctagt ggtatgattc 568141 tcgctttggg cgacttcctg cctaaacagg aagacaaagc atgcgagagg ccctgggttc 568201 aattcccagc tcgccccttt atattttttc accatcaacg tggtgtttca cttattcctt 568261 ttctagtatt ttttttccac cttatagaag cgtgcacgtt taatgctgga gataaaaaaa 568321 aaaaatgcat taatactcta tatagcagaa atatagttgt tataacattg taccaacaaa 568381 agaagcccta tgaagataaa ctatgatcta gaagtatcaa cttgtttgga atgtatgctt 568441 cgttttttaa gttatagagt agttctgccg aaatctcttg cagatgttag gcatctcttt 568501 agatgtattg tctttatgaa actagtatgg tttgaaacga cttttcatgg aatgtttctt 568561 ggctttcttg tgtttctcct tccttggcct cgtggaaacc gattcttttt gaataataag 568621 aggttcgtct aaattaatgg aaccttctct gtcgtcatct cctaagacgt tcattttttt 568681 agagtaatcc caaaaatttt ctggaatatc taacggcccc tgtttgtttt cccaaatttt 568741 aacgcaacca tcttcaccac aggagtataa catgttgcta tgttgtgctg gtataaaaat 568801 atctctgacg acctcgtctc catgggcgtg tgggataaca ataccgtttt cagtatccac 568861 cttctcatct ttaaatggta ggaggcacaa ctctccacaa ttttcttggg ttttaccggt 568921 tgcaatgagt ccagggtaaa tatctaccac gtagtcacag ttccatattt ctcttacatc 568981 accaaagtcc aagggttgtg gctctttcaa ttcgtcagat ttgtcgttca attcgtgaat 569041 tgcaaatgtt tccatatgtg atagtgtaaa tatcctcttt ggggacaacc atccacagga 569101 atgtattgac gcataattaa taacttggtg taaagcgtcc tcctcctcat cttgtttcaa 569161 gtcataaatg ttcgtgtaac catcagttga accactgagc aaaatattga cgtcagaagg 569221 atgaaattta atacaggtaa cgtcatcatg gtgagagtca attaatgatc tcaatggagt 569281 gtcccatttg cgaatatcat atatgtatac agcagcgtca attccctgca attcggtacc 569341 acaggccaat agaccatgac gagaatctaa ggaaataaag ggggagttgg cctcgttttg 569401 aatttgagca atgcggtcat tcgtccttat atcgaaaact ttcaccgcgt cgatagaggc 569461 gctactaact agatgaccag cagagaagtc gctaccgatg accttcatat cattgattgc 569521 agtttcgctc gccttaatct tttgtactga tttaccagta ctccagtcta gcaaacgtat 569581 ttcgccatta cttaatccag ttaaaagacc atgtttataa ctaggctgta acttaagaca 569641 ccaattttct gacccgaaag aattcgattc aactaaagaa taactagcca tgctctagaa 569701 gttaatttga gattctcgaa cttaagtagt ttttatttac acagtaagac gagccagtgc 569761 ctatgtccta atgactgcgt acgtgcactg tagtcccatc taacattttt acaatctgga 569821 ctaagaaaac ttttataaat cacattgcca atgcaaaaaa aaagaatggt ctctagcggg 569881 atcgaaccgc tgatccccgc gttattagca cggtgcctta accaactggg ccaagagacc 569941 actgttatct gttttccacc gtccctccac actaccaaac caacgtcact actgtgtgcc 570001 agcaccaccg ctcattatcc ctgtgccaca aaactcaact tacactgtca ttcgaatttc 570061 cggcaaactc cgactgagaa atgttcgtac tacttccttt ctagggcaca ttgaggaaaa 570121 actcattgaa tgcacccttt acaaatctta atatctctga cgtttgtatt gtattaacca 570181 agcaaccctc cctgtgcaag tagaagccct ggatcctttg tggtcgtaaa atgaacaaat 570241 accaataaga cgaaaacaaa aacaaaaaca aaacgacata gcaacaatgc ggaattattt 570301 aaggctggca ctctttccgc atgtttatca caattatttc cactttcact taaaaccttg 570361 tttaagcttg gcctacacca caggaaaaaa aaccatccga tctaatcttc aaatatcaat 570421 ttgaggttga aaaaatttgc taaagcgttg gtctaatttt gtttttcgcc cacataatgt 570481 ctacatcttt ccaggagttc aaggcctttt gcaacaaggt tgggctagac tttcaatggc 570541 ttaatttgca atcctccaag tctgttcccg aaagcggttc ctctgaaggt ttctcagccg 570601 tcagtgatac cgtacaagaa aacatcagac cagctacgga accacttaac gtcaaccagt 570661 ccaaagatcc tgtcagcaac tttttttatg atgtcaagaa tgctccgctc tggaacgtgt 570721 ataagaggaa tcattccggt cattcttcta ctgaggcttg ctctggagta agttcagggc 570781 aagcgtcaaa aaacataccc gaggcaatgg taaaagagac agtcctttct aatcacgaca 570841 atgtcaccat aataaacgaa ttactgccaa cgtcttctgc catgcaccag gaagaaagca 570901 ccgctatgac aacctcctac ctcttatccc actccgtaaa tgatagttgc aacgtaatgc 570961 tttcttcctc ctcccacaac cgtgctatgc tcccaccttc tcttgtgcaa agaaataacg 571021 ctaccacatc tcccacaaca gactctgcgt cagaaaacaa cgaatcggta ccctcactaa 571081 cctcatctgt tagcacatcc tcatcagttt attcgtcatg gaatcctcct cattctcccc 571141 acatatcgtc atttccagac ggcaatttcg catcgcttaa cgcagaagtg acttgctttg 571201 atttccgccg caccaaggac tccagaacaa aagagacgaa tgaatctatc attccaactg 571261 aaatttactg cccaataaat tccactgatc accacaaaca ttatccaagc caaaaatcta 571321 aacaagatgc ctgcgctcct gctccccgca atcaaaatat aagctgcagc gtcgggtccg 571381 cagcggaatt ttcccagtct aaccacacgt tgactactgt agttccttca tacatgcaac 571441 agtaccttga caggccacag aactggtttg aaagcaaaat gggaaaatac tgtccactct 571501 ttctgagaag tacaaagaac attgactacg attccctcga atttaaattt gagcgcaaga 571561 tgatagctgt tcaatacctg cttttagacg aacaatctga gcccagaagg tactacaatc 571621 cctcaaataa aagtattcca ttctggaaga gacccttcaa cttcgataca atgcccagct 571681 acgaccaact tatggaggaa gcagagtgcc gtttttattc ataccaatac aaatacgaag 571741 gtttccagag gattgagccc tactccattt tttgtccctg gaaaaacaca caaagagaaa 571801 tagatctggt tcttgatcac attcattttt ctctcgatgt cggcgagaag aagtctttaa 571861 accgaaaagg aaacatcact ctcgatactt tagacagtaa ggtcgatcct aacattcaga 571921 tcaagccgta tcagattttt ccgtccaaca acctagtata cgaaggctta ccgcatcccg 571981 ccgaacaatc cttaattttg agtcctggca cctccctcat tgagagggcg tttcaggcac 572041 tgatagacat atgcaaggaa tctattccac cttctaatga ctgtactacc cgcaaccata 572101 atagcgctcc tcagcttacc gtgccagaac catctaaacc atgccggcta ctacttgttc 572161 gtgagtctcg cacagcaaca gaactagaaa ctaacaaaaa gctctggctc cactcacaga 572221 gaaggaatat cgaagtgacc gtaccaatgc atccttctga gcatgggaca aaaagccggt 572281 tacgaaaatg gctctcaact tttgtacatc agtgaaccgt cagaagttcc gatagttcga 572341 actgtttggc acggctgacg aaatactttt aacgagcaag ttagtctaca cataacttcg 572401 tacttaccac cgttttcttc tggcgcgcct cttcaagtag actaccactt ccctcttgta 572461 atagttgtta tatatgtttt catagtctga tttaaatttt acgcatattc atcaattaac 572521 ccaatgcacc aaaaaggcgg gaaagaagca gtaaagcaaa ggcctttgcc aagccttctt 572581 atcgacagaa gcagcctcaa aaggttcctt cgagagcggc gcgcgtattt attcacatcg 572641 cgaatcactg gacccttaaa ataaaggcgc ctattcacga catctgccac agaaacaact 572701 gttcagttat cctagcagca gtttttgcac aacggtataa acctgtacaa aactttagca 572761 aggtttttta acaacaaaag tgcttgaggg acacaacaca aactatagaa cagacactgt 572821 tttcctgaca ctgctttcct gacaagagac tcgtttctga attatttttt ttttcaagca 572881 tctttgtttc gctggaacca ttgagtcttt tcttccattt ttaatcttta ttctgcctcc 572941 tttcctaaac acaagttgat acaacgaggc tgtcaatagc aagagcgtgc gcgagatcat 573001 gctttactcc agagaatcaa ggacaaccgt ccttttcctt gcgttggtta cctccctaac 573061 cgtactttgt cactcggtcg atgtaacaac tgtatttact acgtcaacaa tcaccgaaat 573121 cacaactgtg actgccgcac cgcaaccaca aaacaaagcg gaaaccgctt tgaatactgc 573181 tactaacata attcaaacca tgcagtttct tttcaactgc gcaccattta agtggaaggg 573241 tcctttgaaa ataacttctt gtgcgctgaa ctttattgtc ctactactca ccgcttgggg 573301 ctatcttctg aagtatctgc aggaaaataa gctgaatagc gatgctgata tggaaaaaat 573361 ggtaggactg ggatttgggg aaatggtcgg cagaatcttc ggaaagggtg tcgggaaagc 573421 ttttactaaa atggatatca ctcagaaact agtgtacccg ttcgaaggaa gcaaccggca 573481 gaaatgtcta ctcatgaccg tcggagaaaa ctcgatagtg ccattccacg atttgtttac 573541 agagatatgc tttgaccagt acactctgga ctcgctatcc caccacaacc atgggagtat 573601 ttcgatttta gatgctggat cagtgagcgc cttggggttc gcggatattt catcgaaaat 573661 gccctctgta agcgaactat acacactttt tggagattat acgatagaag tactgggcgg 573721 catcactaaa ctggcttcaa ctcttaacag agaggactgg cagggggaaa gaaacgggtt 573781 cgcggtttta tcgagagacc ggcctaacca gacgttacta agcgtccata tgtactcttc 573841 aagcttgcta tagatggagc tgctcctggc tgtacacacc atacaccaac ttacccctac 573901 atgtacatag tatctgtcag tatttcactt taataggtat taataaaaat ttcaatctgt 573961 gaacactcaa acctgtttcc cagtaaaaat atacagcggc attgagtctt gcggctcgcc 574021 aacttggaag cagccgggaa tgatactact gcaatggctt tttatagtac atatcgactt 574081 tgccagctac ataagggaaa aattaatgtc taaaaaaagc gcttacatcc ttcttgcaat 574141 tgcaagattt ggaacgcaca gtacgtacgc tgcgctacgg gatgagtatt tattgatctg 574201 taagcgtttg attattagac tatgctatca atatttttga tgacgcgggt aaaaaatagc 574261 agacaattcc cgccagatgg aaaaaaagct gggctttaat tcaaggaatg gaaataaaaa 574321 taattttgcg tgagttaact tgagagacaa gagaaggaaa tacttaataa tgatactggg 574381 aaagaagatt caattgaaga cagtaactaa ataatacttt ctaatttttg aatttgctac 574441 agttcggctt tttatctact ctcttctgga tcaatttttc tttttcatct aaagtttaaa 574501 aggagatggg tttatatcaa gcaaagaatg atgagggaag tgatccgaaa agcagcagca 574561 agattgacga tttgatagaa aatgaggcag aaatcatacg actaatcaag gaagatggca 574621 agttactgat agacaatggc gatggtagag atatccataa cataattcaa gaagacaagc 574681 tcctcagtgt agaatttaac gaagtactaa agcgatttca cggggaagaa aagtcagata 574741 ttcctcggaa ggagtttgat gaagacgagg atgacggata tgattctaat gagcaccatc 574801 aaaagactat agaagtaatg aacacactaa atcacgtcat taataaagag gtgattcctc 574861 ccgaaaactt tagccacgtc gttggggaga tataccgtag cagtttccca cgacaagaga 574921 acttttcgtt tttgcatgaa agactaaagt tgaaatccat cttggtacta attccggaag 574981 aatatccgca ggaaaatcta aattttttga agttaacggg tataaaatta tatcaagttg 575041 gaatgagcgg taataaggag ccatttgtta atataccgtc tcatctactg acaaaggcac 575101 tagaaatcgt gttgaatcct gcgaatcaac cgatactgat acattgtaat agaggcaaac 575161 atagaacggg gtgtttgatt ggttgtataa gaaaactaca aaattggtcg ctaacgatga 575221 tttttgatga gtacagacgt ttcgcatttc cgaaggccag ggcgcttgat cagcagttca 575281 tcgagatgta tgacgatgac gaaattaaga ggattgctag taaaaacaac tggttgcctc 575341 tacaatggta atatgtagac agtgattacc tttacgtaac tagtctcttc gaaaatgatg 575401 tttattgata attattatac atggtttctt gccggttata aaattacgta tactatctaa 575461 gcatctaaaa attagccccg caattatgtc tgtaaacgat aaattacagc atatataccc 575521 tcctcatgtc gttaaaagca ttgcgaatag atagatgaat aatgtattaa aaaaggagat 575581 gtttgtatga tgtcccccca gtctaaatgc atagaaaaaa aaaaattccc gctttatatt 575641 catgatcttt cacctcttag tcttctggcc aatttgatat ccttcttttg gatagtaaca 575701 cgcttagcgt gaatagcagc cagattagtg tcttcaaaca aagagactaa gtatgcttcg 575761 acggattctt gcaaagcacc gatagcagaa gattgaaatc tcaagtcggt cttgaaatct 575821 tgagcgattt ctctgaccaa tctttggaaa ggtaactttc tgatcaacag ttcagtagat 575881 ttttggaatc ttctaatttc tctcaaggca acagtacctg gcttatatct gtgaggcttc 575941 ttaacaccac cggtagatgg ggcggatttt ctggcagcct tggaggctaa ttgttttctt 576001 ggggctttac caccagtgga ttttctagct gtttgtttag ttctggccat tgtggagtgt 576061 ttgcttggat cctttagtaa aaggggaaga acagttggaa gggccaaagt ggaagtcaca 576121 aaacagtggt cctatataaa agaacaagaa aaagattatt tatatacaac tgcggtcaca 576181 agaagcaacg cgagagagca caacacgctg ttatcacgca aactatgttt tgacaccgag 576241 ccatagccgt gattgtgcgt cacattgggc gataatgaac gctaaatgac caactcccat 576301 ccgtaggagc cccttagggc gtgccaatag tttcacgcgc ttaatgcgaa gtgctcggaa 576361 cggacaactg tggtcgtttg gcaccgggaa agtggtacta gaccgagagt ttcgcatttg 576421 tatggcagga cgttctggga gcttcgcgtc tcaagctttt tcgggcgcga aatgcagacc 576481 agaccagaac aaaacaactg acaagaaggc gtttaattta atatgttgtt cactcgcgcc 576541 tgggctgttg ttattcggct agatacatac gtgtttgtgc gtatgtagtt atatcatata 576601 taagtatatt aggatgaggc ggtgaaagag attttttttt tttcgcttaa tttattcttt 576661 tctctatctt ttttcctaca tcttgttcaa aagagtagca aaaacaacaa tcaatacaat 576721 aaaataatgt ccggtagagg taaaggtggt aaaggtctag gaaaaggtgg tgccaagcgt 576781 cacagaaaga ttctaagaga taacattcaa ggtatcacta agccagctat cagaagatta 576841 gctagaagag gtggtgtcaa gcgtatttct ggtttgatct acgaagaagt cagagccgtc 576901 ttgaaatcct tcttggaatc cgtcatcagg gactctgtta cttacactga acacgccaag 576961 agaaagactg ttacttcttt ggatgttgtt tatgctttga agagacaagg tagaacctta 577021 tatggtttcg gtggttaaac aatcggtggt taaacaatcg gtgtttgaaa ttattttcat 577081 gcctttcaaa aaataaaata acgatcattc tattgggaat ataatagaac cttatgtatg 577141 catttttcgg ttttttatta tttcatgtac tatatatatt aaaaataagt ctcaataaaa 577201 gaaactagtt tccgaactgt cttagatagt cttcccttat gtgctcctcc atttcattgc 577261 cgttgagtgc ttcgacgtgg cgttcgtgtc ccctctgttg gttaagcaga tttacccaaa 577321 tatttacgca gaaacccatg gaatcctcaa tttcacgctt tttcttggga catctgcacc 577381 tgcagccaca cccaaattcc cttccctcgt cgtaggccgc gtttttacgt ttgaattttg 577441 agtcactggc taagtaggag aattcctcat tccccatggc attatgtgga caatgctgta 577501 ttgtggagtg tctatatccg atgtctctaa aatagtgtac atcgtccaaa tccagagtta 577561 gcgacaatcc aatagagtga acaggagcgt ccccccatct ttccttccaa aatccaccac 577621 ttttctccaa atattgaaaa aaactgttgt aaatgtcatt gtcgaacacg cttagccgcg 577681 caatctcaaa attactccag aaatggcata gattgtactc ttcattgaaa aatttgtctt 577741 ctacgatatg cttcctagag cgagccttat gtatcaaatt cattattccc tctttgtcat 577801 catttatctg ttggaaatca tcaccctttt tcaaaagctg ctcgatggct atcttttcgg 577861 atatcttagc cttggcctga aaatcatagt tgatccagtc ccgtaactcc ggatcatcgg 577921 attcaaaaat gtcgtaatcc tttgtaaata gtttccataa tgacccaagc gtaacgcctt 577981 tttgactgat aaagctttta gtgtgtctaa acaaatttgg gactgtccaa tacaattcgg 578041 ggatgatgat cgtaaatcca tatttcttat tagttcggag catctccaaa aagggatcgt 578101 aggtaatatc acagaaaaac tcaacatcgg gttccaatct ccaataccat tcgtacttct 578161 gtactagcgg gtgcttgtaa aataatcctg aataaaaccg gcacatctta tgatatgatt 578221 ctaagtttcc gtaaagtatg cttctatcac cttgatcctc aattgcgttg tagaactcga 578281 acgtatcctt tacgtcactg ggaaaattcc aagatatctc atcgatagtg ccaaattcca 578341 ccagcgcgcc cactgtaaca tcacgtactt ttgctttgaa gtcctcttca aacggctggt 578401 catttaagaa cacatatgga tagtggaacc actgattgaa atgctcttct atactgttga 578461 tagtcttgat aacatcttct agctccccgt tccttgttag catgacaaac gaggcattct 578521 gcttgatgta cgatggattc aacaaatagt cctgagtatt cacacaattc gaataaaagg 578581 gtctgtccct cttcgtcgca agatccatct tggaaaacgg aagaaaattt cccatagttc 578641 cgtctacgga tgcaggctca gatacaagta ccacatacat ggttatgacg aaggcaatca 578701 ggatgcacgt cgccgtaaga ttgcaatgga tacatcccag aaatgcattt atcgtccttc 578761 ttattagcaa catctgctac cttatgacga tgtgccgtat tgagacacat ttattgatga 578821 cacctccatt gaacaagact atttgtgcac ggaagcactc atatctacta cttcgcattt 578881 ttttgaagac cctttctcga atgcctgccc aaatttttca attttcttgg catcatccac 578941 acaccgcatg cttaaagtgt actatccaaa aaatgagaga aaaagcaaat acctaaaagc 579001 accccacctc ttccatatcc cacgtaatgg caattggcat atatgctcgg caagggaaat 579061 tactggtcgt aatatagtgc aacatgcaac ttgccaggcg cactatagtc acatcttatt 579121 atgttagcag ttgagctcca gctttgactg cactttagct tagttgcaac ttcgcccctc 579181 tgttgggggc tgaaaagtac atccgcgcat ttaacaattg ctaagctatc ttgaataaca 579241 ttatactaat taatatctat agaagcagaa tgtctactac gtcgaggacc ctacccctgt 579301 atttgtgcct tgcatgagcg agctatatat cagcgatacg tttttttgtt ttcctttcga 579361 ccttcttgcc taccctctca cttttcccac ctgaattttt tttatcatat tagtccgata 579421 ttgagtttat aaaccttgtg aagtgctaga taaagtacaa tcaaaagagc aggcaatagc 579481 catcacagca gtttagtacg attatacact ctgaacgcga gtaaaactag gttgtatttt 579541 tagtctcgat tggaagtttc gtcagacagt acaaggaaga tgtcattcag caacggaaat 579601 atggcttcct acatgactag tagtaatgga gaggagcaaa gtataaacaa caaaaacgat 579661 atagacgata acagcgctta cagacgtaat aatttcagga atagtagcaa ttcaggatca 579721 catacgttcc aattatcgga cttggactta gatgtggata tgaggatgga ttccgccaat 579781 tcatcggaga aaatatcaaa gaacctttcc tctggcatcc cggactcatt tgattctaac 579841 gtgaacagct tgctgtctcc gtcaagcggt tcttattctg cagatttgaa ttaccaaagt 579901 ctatacaaac cagatcttcc acagcaacag ttacaacagc aacagttaca acagcaacag 579961 caacagcaac agcaacaaca acagcaacag cagaagcaaa caccaacttt aaaagtcgaa 580021 caatctgata catttcagtg ggacgatatc ttaacacctg ctgataatca acatcggcca 580081 tccctcacaa accagttttt atctccaaga tctaattacg atggtaccac taggagctcg 580141 ggcattgact ccaattatag cgatacagaa tcaaactatc atacgcctta tttgtatcca 580201 caggacttag tttcttcacc tgcgatgtct cacttaaccg cgaataacga tgattttgac 580261 gatcttttga gcgtcgcatc tatgaactca aattatttac tgcccgtaaa ttcacatggt 580321 tataaacata tttcaaacct tgatgagttg gatgacttgc tatctttaac atattcagac 580381 aataaccttt tatcagcatc aaacaacagt gatttcaaca acagtaataa cggaattatt 580441 aataccgctg acactcaaaa cagtaccatt gccattaata aaagtaaagt cggtactaac 580501 caaaagatgt tattgactat tccaacttct tccacacctt ctccttccac tcatgctgcc 580561 ccggtaacac ccatcatttc tatacaggaa ttcaatgagg gacacttccc agttaaaaac 580621 gaagatgacg gaacgttaca actaaaagtt cgggataacg aaagttatag cgctactaac 580681 aataacaatc tacttcgtcc agatgataat gattacaaca acgaagctct cagtgatatt 580741 gaccgctcct tcgaagatat cattaacggt cgaaaattga aacttaaaaa atcaagaaga 580801 agatcttctc aaacttccaa taatagtttc actagcagga gatcctcgag atcaagaagc 580861 atatctcccg atgaaaaagc taaatctata agtgcaaata gggaaaagtt attggagatg 580921 gcagatcttt taccatccag tgaaaatgac aataatcggg agcgctatga caatgatagc 580981 aaaactagct ataacaccat taacagtagc aattttaatg aggataataa taataacaat 581041 ttgttaacaa gtaaaccaaa aattgaatcg ggcattgtca atattaaaaa tgaactagat 581101 gacactagca aagatcttgg catacttcta gacatagata gcttgggcca atttgagcag 581161 aaagttggtt tcaaaaatga tgataatcac gaaaataacg ataatggcac attttctgtt 581221 aagaaaaatg acaatctaga aaaactagac agtgtaacaa ataataggaa aaatcctgcg 581281 aattttgctt gtgatgtatg tggtaagaag tttacaagac cttataactt aaagtcacac 581341 ttaagaacgc atacaaatga aaggccattt atttgttcta tttgtggtaa ggcgtttgca 581401 cgtcaacatg atagaaagag acacgaagat ttgcatacag gtaagaaaag gtatgtatgc 581461 ggtggtaagc tgaaggacgg taaaccctgg ggttgtggca aaaagtttgc aagaagtgat 581521 gctcttggta ggcattttaa aactgaaagt ggtagaagat gcatcactcc cttgtacgaa 581581 gaagccagac aggagaaatc gggacaagag agttaattat ttttgttttt ttaagctttg 581641 aataggaatt ttttttttct atataataaa tatgtaattt cataatgaca gtgtagaaat 581701 tatggctaat ctaatccatg caaaggtatt atttggttat tgtttttgta atgaaatagt 581761 ataaaacagt gatattctta cggattaata gtttttacgc ccgtctgaat tttctaagct 581821 gccgaaaata atggcaagta acaaaaagtt attgtatgag gatgcgtttt acgtggcaaa 581881 agttttgatg ccaaatagac aaaagtagct caattcaaca tgacctcatc atctggtgtt 581941 gataatgaga tttccttaga cagcccgatg ccaattttca atgagagttc tactttaaag 582001 ccaattaggg ttgcgggtgt agtaacaaca gggacagatc atatcgaccc tagcgtacta 582061 caggcatact tagatgatac tattatgaaa tccattactt tggggcagct agtgaaaaat 582121 gcggatgtgt taaataagag attgtgccaa caccacattg ccttgaacgc caaacagtcg 582181 tttcacttcc aaggcaatac atatatctcc gatgaaaaag aaacacatga tgtggtgcct 582241 ttgatggaag ttgtttcaca attagatata ttacctccta aaacgtttac agcgaagaca 582301 gggacaaatt ttgggaacga taatgatgca gaggcttact tacaatttga aaaactaata 582361 gataaaaaat acttaaagtt acctactaga gtcaatctcg aaattttgag aggtacaaaa 582421 atacactcct cctttctatt caattcttac tcttctcttt ctccccaatc aattctaaac 582481 ttgaaagttt ttagtcaatt ttataattgg aacacaaata aaggattaga tattgggcaa 582541 agaggagcaa gactatcttt gaggtacgag ccactgttct tacataaact attacacaat 582601 ccgcattcta atgaaagtcc cacgttattt catgagtggt ttttagagac ctgctggaga 582661 tccactaaga tatgttcaca aggcactagt gcgccctata tgtattcagg tacaatgtta 582721 tctcaagcag gcgatcagtt aaggacaatt ttgggtcata cattcgtgct ggacaagaga 582781 gatcatatta tgtgccctac taagggttcg atgttgaagt ggagtaatga actttcgcct 582841 ggaaagcatt taaagaccca attagaattg aacagtgtaa aaagttggat gaatgacgac 582901 tttattactt tttctactac cattaaaaca ggatatctaa agaacttatc ctcacaacaa 582961 tccttgcctg tacatatatg tgataagttt cagagtggtg ggcccagcga cattcggggg 583021 tttcaaacat ttgggttagg ccccagagat ttatatgatg cagtaggtgg tgatgctttt 583081 gtttcctatg gtcttagcgt attttctcga ttgccctgga aaaaagttga aaagtcaaac 583141 tttaggttac attggttttt taatgggggt aaattggtta atcatgacaa tacgtcgttg 583201 ggtaattgca taggacagct ttcaaaggaa cactccacat ccacaggtat tggtcttgta 583261 ctaaggcacc caatggcaag attcgagcta aactttactt tgcctattac cgctcacgaa 583321 aatgatttga taagaaaagg attccagttt ggtcttggtc tggcattttt ataagaatac 583381 attcctttta atgtcaaggt gaagctatcg cctagcttcc cattcaatat ttttcatatg 583441 ttatatagca acatattcta taaaagcctc actaatagct gtgctgcacg tatggtaatt 583501 aattcctgat tcagagaact cagaaatcca atacgtttgc cttaaaatgg aggagcaact 583561 ttttctgtgc taaaagttgc cgctcatgta ttgaaggcat aataaaagaa accaaataat 583621 ttgtagaaca aaatggcaga taattgtgct agaagataaa tacttatata tcgcaccatc 583681 gttattttga gttttctttt agtagttcgt gtgattgcag caatgcgatc tttatcctca 583741 acctcatttc acacaaaatc aagactatga tgctgttcaa ttttactagt ccgtgtccac 583801 ttatatatat gcaaaagtat tatcaaacac tttagaaaag gaagaaaatg tttttgaaat 583861 aagccaacat gttctagtat tttaacttgg ggggcgttta atatttctgt tagtttatca 583921 atttggcctg ccataagaat ttctgacaaa ggttttgtgg ttgcacatac tctgaaaaat 583981 ggggaagttt gagccacggt tcacccatct tgaatgtgtg ttataagtgg gctactgcag 584041 tagaccaaat tgaaaggatt ttttgaacac tggagaaaaa aacactaggt tcgattcttt 584101 aaatttaata catgtcaagg tccgacccag ctttccacct caatatcaaa gcaattttta 584161 attatgcatt ataacggtac ctattctcaa tatgtcttga cgttccaata tcatgttaaa 584221 caaaggtagt caaggacgaa acatttccaa aacggatcat caccaccata atgattgaat 584281 ttacaggctt aacggttttt aaatttattc ttcgcatgat taaattgcag atgctggtct 584341 aagatacaaa gtatgtagca gaaactttat ccattgttcg tggtacttgt cccaatgatc 584401 gtataatgta atttgctctt gaatcgtatc cataacctcc tcaagatcta caagagattc 584461 tgccataaaa cgattaaaag ctatttgaac aggagaacta gaatttttag gatctctgat 584521 ggcttcagaa gccgcagatg ctaacgatga tcctttggtt ggtttcccat gaatggaaat 584581 cgtaatgaat aaacatgcaa cagcgataat atgaggaggg taaagcaaat gaacatcatt 584641 tatataactg tcgttgatta aggaccaaca gttttgtaga tcatctgacg atagtgttat 584701 ttgaaatggc ggttgcttta agacttgaac aatttgcttt aaggattgat aagggtggtg 584761 gacaattaag taactttcca attcttctag taagtagaac tcaaactcag taactttagt 584821 agggtcagga ggaataaatt cgggccataa ggtacgggct tcacttacca aagttctgat 584881 atattgcggg cattcttcaa ctttgcatgc taaatataca cacgtagtaa ccagcatata 584941 taggtttatt tctctaactg aagcctttat taaaaacctt gatagataaa tatgtgctgt 585001 agccagtgca tactgtctta tatttagtct ccttccaagc ttcattatca ggaaatagca 585061 gtagatcctt agattataat ctttatcata gtgtaagtct cggtgagtta ttggtatatt 585121 ctttgtgatg gattgttcga tgccgttttg cttcgaatcc attacaatat tcaaaccttg 585181 aggaaacagc tggcactcca atagccataa cttctgcctc tctttagcca atgatgcctt 585241 ggtatattgc caatgatgcc tttgtgtaga tgtccagaag ctccccgaca tgtctaactt 585301 ttgagattca gatgccttat cgctcttcaa ctaaagtttg agagggcatt ttttgttcga 585361 acaatatgag tgctaacaag gttgctacca catcaatgaa ctctactcct gtatgaaccc 585421 taattttcct tcatgaaaaa tgaattttcg atgtttttcc gtggatttta tattttttca 585481 aatatataaa ggagtaagaa aataactttg tttatcctat gttgcggtaa agaactaaat 585541 agtggtcttc acctgttttc taatttcttc tcgtttaaag ttcttcaatc catgaccaaa 585601 gaatcgtcac aaatcgaagc ttacaaaatg gagtaaaatt ttttttactc agtaatatgc 585661 tttgggttga aagtctccca ccaattcgta tgcggaaaac gtaatgagat ttaaaaattt 585721 taaattgttt aaatcaactc attaaggagg atgcccttgg gtattctgct tcttgacctg 585781 gtacctctat tgcagggtac tggtgttttc ttcggtactg gattccgttt gtatggaatc 585841 taaaccatag ttatgacgat tgctctttcc cgtgctggat cgagtaaccc aatggagctt 585901 actattcttg gtccatggat tcaccccttt ttattttttt aacagtttgt tgtttacact 585961 actttttagc agtgtaaaac ttttgcatag ttaaatatgc cgaactgatc taataaaaag 586021 tctgaataac tcagatgagt tatttattgg taaacttgtg taagaagaag atggaatagt 586081 gaataattca tcaaatgatg aaataccaat gcaacagagt caagctctga gtttcaaaaa 586141 gaaacatgga cgagattgct tttttattac tgaccatgat tattcattac ttaccattgt 586201 tcctcattct atataattga ttgggcacca cgtaaattct tgagcctttt cggtagtatt 586261 caatcgcaat atggggtagt ttacggaagt gctgtaaatg atgtctaaaa tgaacaacta 586321 tgcgtcctta ttgtgacaat gaattccctt cttaaatctc tatagaggtc gaatagatga 586381 atactcaaca caaaacacta taaaataaaa aaaaatacaa aagtgtttat atttttgctg 586441 tgcgtgctag ctcatagcac ccttacttgt acgctatcag acgatagaat taaagagaca 586501 cttcgtctga atccacttat actctttgtt ttaaaaggta ctgcaccttc tatgaccttg 586561 atttgcgtaa ctttaaatcc atatgactaa gtatcttcca atcagctgtt aaattgactg 586621 atggccatca aaatacatgc taaactaaca tatggactgg ccctttcacc aacacgtgcc 586681 attttccaga aggcccccaa aacctcatga tttttgtaac gatctaggag agacggccac 586741 tgcccatgaa cataagaaca tgaacaaatc agtaacaata tcacttgcag aagagaacga 586801 aaattaaata atgcagacat attctgtcgt ggaaaaagga cgcaactttg caaagtaaat 586861 cgatccggct ctctagttat tttgcaaacg atgtttaccg ctgttctgtc tttatccttg 586921 agttgtcgtt gctcactcta ttgaagatca aaatttcgct caagaagagc agtcccacca 586981 tgcgtacacc acactacaaa aatgaatgtt atatcgtttt ttcatgaatt acaaatgtct 587041 atcgaaaagt tcattactaa atataataag atcaggatca ttaagagata aattcactgt 587101 gtcaggttac ttcctgataa gctgaaacaa gtgggttctt tccttaagat aatgttcaaa 587161 tttactaaaa tctgtaattt caagaacgtc aaaatttctt ttaatcttgt tgaaaaaatg 587221 tttatcagct tttcttctct tcttgtaagc catcaagatt acaggtgggt ttatgcagtg 587281 agtgagatca agtagtgttt tttctagtaa tggaaaagct tcctcgagat acacacaatc 587341 agctgccaaa actagatcaa cgttatttgc ttgcatagca ccttcttgag gtgagaaatc 587401 tgccgacagc ggctcacccc accaaagttc cctcgcaaga acttcatact gaacttcgtc 587461 cagttctata tttcttttca atagtggtat caacttgtca atgtccgtaa catatacttt 587521 agtgccatcg tggaatgtgt ttttttccaa caaccccacg cacaatccaa ctaaacctgt 587581 accactaccc aattctaaga cttttttaaa ttgtttcgta ccattgaccg tcttacttag 587641 cagatggtca actgatttct cgagtatgta ctcgcacaac agttcgccag cgatccagac 587701 tttaccgcca caaccacttt caccgccatc ttcacaaatt ttcaatgcag gcaataattt 587761 tccaccgaag gaaaggtctg tttgaccgag atgctccttt ggcctaggaa caactagatc 587821 tccaaaccca ccaaatatac tctccatact caatacctca ctagtcgcgt ttttataacg 587881 ttctagggaa aattatgggc cattttttta catagagcct gctcatcata acttttgaat 587941 tatttaaata cgaagaatta ctttcagtgt ttgggtgtga gggacttttc gtttggtcaa 588001 gccaaaaaag cttaagagaa aagaaaaatc tcttctggtt ttacttgact aggtttccaa 588061 attataatat ccgtattatt aacgtgacac tcagtattct ccattcgttt acgggaacgt 588121 tgatatgtaa acatatgcag atcctcgtat tttagcaacg acagggagaa acaagaaatg 588181 agataggatg aaaaaaaata aaagttagat atttctattt aattagaatt ccgcgtaata 588241 aataatgaca cgctattata gttcatgtat tattatccat tacaggacta tcctcttgaa 588301 ttacgggcgt atccaacctt ctttcaagtt cttcttcagt tgaacacaac gaaatggaat 588361 cggccaaaaa tgcctctttg gccataaaat cgaagtgtcc aaccaaaagc tccatgtcac 588421 gttcggtatt cacggatgct gtttcgtaat tttcaggata cactagtgct gttttgccat 588481 catcaaggat taggtattga ggattcacta ctaacgtatg cttgagatgt ggttcaaaaa 588541 atctccttag atcttcggca gtatttccag caaccaaatt ttgaaccaaa aaaccatttt 588601 tcttagccac ctctacttta ggttccgtat cttgaacctc gaagttgatt agtttagctg 588661 tggtgcgagc ttgaaattct tgtgctttcc tttccttctg caattgttta aatgattcat 588721 atagtgggta agcttctgct aatgataaga ctggtttatt gcttgcgcca ttatcttctt 588781 tcttaataaa tacagatctc atgggctctc tgtcctgaga ctcggaatat aggccgtaag 588841 ctttggctag ttcacggatg aagtggcgtt gaggaggcct cataggtttg aaatgcaagc 588901 ttgaacgtgt tttatcgtcc attaatttat taagaatagc ttcaatttgt gaacaccatc 588961 tttcttgctt tgaatatact gataatgctg cctctgtaaa cggtaactgc agttcttcaa 589021 atgttgtagc aacagagacc agttttttta acgcatctag ttcattactt gtaaaattat 589081 tggtttcttc cttaattcca aatgcctcct tcaattcctt tagtcgtttc aaagcttcac 589141 attcttcatt gcaatccagc acggaagatt cagttacact tactctatca ctttttgcgc 589201 cacaagtaac actttttttg atccttccac atttacaata aattttcact agcgtggcac 589261 aaggtaaatc gggacactct gtcttaccat ggcacggttt aggacattca tgattacaat 589321 tgagcctttt ttgcccacag gtctgtttac acaccttttg gcaatttcct ggtaaatgac 589381 atgttttttg gcaggtatga taacagtaag agagtggtat cccacatttt attccacatg 589441 atacgtctgt ttgaaaacaa accgttctca ctttagtttt cttcccacat ttacaaggtt 589501 taaatacggt ttccgtacat ggcgggcacg acacatccaa ggaatgacag gtatgtggca 589561 ttggtttatg accacacgta gattcgccac gcacaacttt aatacatgga tgattacatg 589621 taggtagctt cgtgccacaa cgcacgggtg caggaacaac tgtattgcca catgggcaga 589681 ccagatcgtt cgaatcactc tctaaacagg gcggacactt tcctgggtga cattttctct 589741 gacatttatg aattccacat gatagggtca agttacacgg ttttaggcag atatgttttg 589801 cttccacaag agactcatcc aacaaatctt gcgttctgaa caagtttttc ttccttctta 589861 tcgccgatgg cctaccactg cagcacctat cggtgcatct atgtctacgg catgacatca 589921 gggattcgca tttaatattg cagcgaggcc ttccttgaaa tccacatgga actgaaaatg 589981 tactttgctc acaagcacat tttacactat caatttgcaa gcagggttcc atacaggctt 590041 tatcatgaca agtgaagggg cacgaatgtt tgccacattt tagtggttta ccgcatcttg 590101 agtcgcaggt tggtatcgga tcatcacaat gcttacgagg cttagtcagt tcctctaggg 590161 ctgtccggcc acagggacaa gttttcaaag agctaggcaa aaatgggcat gccttttctc 590221 cattaattgt gggtgggctt atgcaagatt ctatgaatga atgcttgcga catgagtagt 590281 cgacaactct attatctgca caggcaaaca cgcctatcca cctgttccca ttttcatcct 590341 tcgacgactt accggacttg ggaaactttg tttcactaca ctttatgtta gcacgagtgt 590401 ggttaccaca gtagcatttt atttgctttt tcggactatc tttactaatt atcatttctg 590461 gacatggccc acataagcca gggtggcatt tctttttaca ggtgtggatg gagcaagata 590521 aaggcaatcc acatacttct tgacagttga agtttttttt cataacttta gactggtaac 590581 aaaagatact tttcgaatgc ttaccacagt ggcacataat ctcgaccatt ctagtacact 590641 ctggatgcgg ccctagatga caaattttgg aacaaccatg catacaagta gaagcattgc 590701 aggtttgtcc acatgagtta ggatccagcg gattcggatc aggattaaca actttaccgc 590761 accaacatgt gggccgattt tttaccggaa ctcttttgct aacataatag cagtttggac 590821 atttccatat tctatctacg gttttttccg ttgattttaa cgcccattct cttatgcatc 590881 cgtaatcaaa cactctataa catctcttgc aagcaaacat ttggcacgta taatccatct 590941 ctactgtaca aatcatacaa acatatgagt caccgctaga aatttcctgg atcgcacgtt 591001 cgtaatattg catatcatca tcactttcct cttcatacga actaggctgc tcgttggcgt 591061 cttcaacact cgaaatacac ccatcgctta ggttgtgatg tctataagtg tcaccgccgt 591121 cttgattttg ctccaggcct aaagactcat gttcggtcat ttgtaatgcc tacgactgca 591181 aatagattag agcagtctcg tctcacgctg tttcacttgg ttgttgccac tgtcgcaaga 591241 aagaactttt atatttacga ccttttcaca gagctcatcg ataattttta taatagtata 591301 ttacccgaaa atcttccttt atgtgcggga tgtatagatt attgaaatgt cttttccgta 591361 gtactacagc aaaaatgcaa taatacatat cagatataca catatataca tgaatgttct 591421 gaaagtttaa tctctttcaa aacagacagc aaagaaacca ataccaccgt cactttttgg 591481 tagtgccctg atacaaccct cggcaagctg ttgagggtca taggtgactc catctctaaa 591541 aacctcttcg aactcttcta ccttgcctct tctaggccaa gaaggaataa cttctctttt 591601 tggcgctact ttccaacccc attctctaac tgacttatct aaaagaaggt ctatgacgac 591661 tcgttcattt tcttccgcat gaatggaaca tgtgctgtat actatttttt tagccgctgg 591721 gaaactcatt gcatgcttta ccatctggaa ctgaaatgaa ctcagcttcg ctaaccttgt 591781 ctgtagttct tcctttgcta taaactcctc ttgctcatcc ggcacaatgc caccatcgtc 591841 atctttatca tcaattttcc ttctattaaa tgagtcaaaa aacttacgac caaatatacc 591901 gctaccggag cagctcggat ctacaataaa acaagtaacg tccttatatt tttcaggagt 591961 agcgagcttt gtaaaatcac ctacattgac actgatgttg ggagaacagc cagctatctt 592021 gatcattttt tgtaaaactt ttgctctttc aggatccttc tcgaaagcgt atattcgagt 592081 attattgtcc ttcggtggtt cgggatatat ataagaggcc gtatgggtag tcttattacc 592141 tggagcagag caggaatcta tcacaatatc acttggtcct ggattcaaaa tgtgggctgg 592201 aaaacaagaa gcacgatctt gaatgataat cttcccatgc ttataaagct catgtgctgt 592261 aattttgtca gacggatgaa ttccaaacaa gtttggaata aactcatcat aatagataga 592321 cccaggaact agttcagacc atttgtctac ctttaaagta aacttcttcc tcaattcggc 592381 taacaccggc tcagtctcac catttggatg gcattttaat ggattgattc taatccatct 592441 aacaggagga aggtcattgg aaatatcctc gcttaatacc aactcagata gctctcttac 592501 tttcaatttg agtttcaatt tgaccatttc gctatgcaat gggctcttaa acttcaaaac 592561 ataatctttg atggggtgtt tgcccatttg aattcttttc tgcttagaca acagcaaatc 592621 atggcaaagc aataacaaag ttagccttga aaagagtggt ttgccctttt tcttgggtat 592681 atcttccaat atgtgtgcct ttttcatcac tttctccaaa tatggtttat atttccaaca 592741 cgaatcgaga actgcataaa tatgttttgg attacttttc agcttatatc ttttacagct 592801 tttcagtacc agcgtctgca tagagccgga aatcctttct tttgcagcct ccttctcaat 592861 atcttctagc acccatgttg catccctgta gaaattcatg ctttttcgta gctaacttct 592921 cagtgaaaca cttggtgaag aaccagctct tctcttaacc tcatcgaata ttttaggcca 592981 gttttttttt tcctcacttg ccattttccc gcaccgtttg gaaatctcga ggaaaatgct 593041 tctttccaaa agtttaatca ggtcactaat taggtaaata gagctgggag gaagcatata 593101 cagtgtttcg tctgtggaag gaacttttat ttttcttaaa tgttttaatt tttagtgacc 593161 taattcacat aacaaaatat tgagaaaggg aaagttgagc actgtaatac gccgaacaga 593221 ttaagcatgg attctgtaat ggttaagaaa gaagtactgg aaaatccaga ccatgattta 593281 aaaagaaagc tagaagagaa caaagaagaa gagaatagcc tctctactac ttctaaaagt 593341 aaaaggcagg ttattgttcc cgtttgcatg ccaaaaatcc attattcacc gctgaaaact 593401 ggtctttgct atgacgttag aatgaggtat catgcaaaga ttttcacatc gtacttcgag 593461 tacattgatc cacatccaga ggacccaaga agaatatatc gtatttataa aatactagca 593521 gagaatggtc tgattaacga ccccacttta agcggcgtgg atgaccttgg tgatttaatg 593581 ctgaagatac ctgtaagagc cgcaacctcc gaagaaatct tggaagttca tacaaaggaa 593641 catttagagt ttattgaaag cacagaaaaa atgagccgag aagagttatt aaaagagact 593701 gaaaaaggtg attccgtata tttcaataat gattcttacg cgagtgctag gctgccttgt 593761 ggtggcgcca ttgaagcatg caaggcggtt gtcgaggggc gtgtaaaaaa ctctctagct 593821 gtcgtaagac cacctggcca tcatgcagag cctcaagctg cgggtggttt ttgtctcttc 593881 agtaatgttg ctgttgctgc caagaatatc ttaaagaact acccagaaag tgtaagaagg 593941 ataatgattt tagattggga tattcatcat ggtaatggca cacaaaagtc attctatcaa 594001 gacgatcagg tgctatatgt gtcattacac agatttgaaa tgggtaaata ctatcctggg 594061 accatccaag gacaatatga tcaaactggt gagggtaagg gtgaaggatt caattgtaat 594121 attacttggc cggtcggcgg tgttggtgat gcagaatata tgtgggcatt tgaacaggta 594181 gttatgccta tggggagaga attcaagcct gacttggtga ttatttcttc agggtttgat 594241 gccgcggatg gtgatactat cggacaatgt catgtcaccc caagttgtta tggacacatg 594301 acacatatgt taaaatctct agctagaggt aatctttgtg tagttttgga aggtggatat 594361 aacttggatg cgattgcaag aagcgctttg agtgtagcaa aagtactaat aggggagcct 594421 cctgatgaac tacctgatcc attaagtgat cccaagcctg aggtcataga aatgatagac 594481 aaagtaattc ggttacagtc caagtattgg aactgtttta gaaggagaca tgctaactcc 594541 ggttgtaatt ttaacgaacc tattaacgac tcgataatat ctaaaaattt tcctctgcag 594601 aaggctattc gtcaacaaca gcaacactat ttaagcgacg aatttaattt cgttacttta 594661 ccgttagtaa gcatggattt accagataat acagtgctat gtactccaaa catttccgaa 594721 tctaacacta taattatagt cgttcatgat acttctgata tctgggcaaa gagaaatgtt 594781 atttcaggta caattgactt atcctcatca gttatcattg ataattctct agactttatc 594841 aaatggggac ttgacaggaa atacggcatc attgatgtaa atatacctct aactctgttt 594901 gaacctgaca attactcagg aatgattaca tcccaagaag ttctaatata tttatgggat 594961 aactacatca agtattttcc ttctgttgcc aaaattgctt ttattggaat aggagactca 595021 tactcaggta tcgtacatct gcttggtcac agggatacta gggctgttac taaaacggta 595081 attaatttct tgggagacaa gcagttaaag ccactagttc ctctagtaga tgaaacattg 595141 agtgaatggt acttcaaaaa ctcacttata ttttcaaaca atagccacca atgctggaaa 595201 gaaaatgaaa gcagaaaacc aagaaaaaaa ttcggtagag ttttgagatg tgatacggac 595261 gggttaaaca atataattga agaaagattt gaagaggcta cagactttat actggattcg 595321 tttgaagaat ggagtgatga agaatgagga aaaactggcc attaataatt ttttttcggc 595381 aaccttcatg ccttatgaaa gttgaataat aataaagttg ttacaatgtt cattgtataa 595441 tccaatatat ctaaaatagg aaaaagaaat gaacaaatgc attaagctgt gttttactaa 595501 gtattatggg aaaacgtata cattaaagtg gatgcttaca tatataacac attgtaataa 595561 aggttctttg aacatgttac cagcctcttc agagatcgat ccggttctgt tgagccaaat 595621 actcacttat ccaaggataa ctttcgtccc gcgaggagca gtggttttgg aggaggttta 595681 ggctttaaat gtgaaggctt aggtggtggg gtaggttttg tttttttgtc ttttgaaatc 595741 gggccacttg atttcagcat tgttggctta tctatctccc ctttctcatg cagcttgacc 595801 ttggacattt tcctagcgtt gaatgactcc tcagaagagt tgagtttatc gatcatacgc 595861 tgttgaatgg agttcttcaa attctgctta gatacgtcca aatcttcata agatggtttg 595921 ttaagatcgt ctttggaatt atcaatcgta ttaacgaatg tcgacttaaa aggtgaattt 595981 tcgtgtttca aatttacctt tgtagacgtt ggggtgaagc tagtgcctgg taggcttgat 596041 gaagtaagag attcctttac ggattggttt ttttttatgt taccgcgtgt ggaataagaa 596101 cctagagatc gagttttctt taattcatct acgtctccag aataagattc atctgaagag 596161 gaagaagaat cttcgtactg gggtattatg ttttgtagtg gaaagtctat tgaattattc 596221 tgcctaaaag tatgtgcttc agagacaatt gcctgcttta acttggttgc ggaatttgcc 596281 ttgagttcgt tgtcattatt tgaaacacta ctcgctagcg gttcaacaag tggaggatcc 596341 aatgcgtggt acatattctg tgatttgtca aaaagtggtt gagaaccttt ggcggaatta 596401 ctgaagctag cgtcatatgc tatttgtgat ggttttctat taggatgcat ttgtgctgtt 596461 gtagtattat cagccatgct gatttgaaat gtagcgttcg gcatcgtatt ttccatggtt 596521 gtgggagagt tcaagcttag aatattttgt gttgccgaaa gctgatgaag ttcggtcaaa 596581 ttcaaatggc tactgggcgc ctgaaccact tgtatgtcat ttattggaca cggaacattt 596641 tgcataattg atatcctctt cagtagttga taaacgttag gcctatggcg cggatcttga 596701 accaatatat cacgtattaa gcctttcaac tgttcactgt agttcggata caatggaaat 596761 tcaaactttc cgcttaatat ggcaagatca ccgccctttt caaacggtgt tgtgtaatag 596821 caaagcttat atagaaaaat acccagcgcc catatatccg acttttcatc tatcggcaga 596881 ccgcgaaatg tatcaatcat ctctggcgac cggtactgtg cagttgtgtt tttcaaaatg 596941 tcttgctgaa catatgatag ctcttgtgaa ttcctaggag gccttataat accgcataca 597001 gaaccaaagt cacaaagctt gtactcatta ttggctgaga taagaacatt ttctatcttt 597061 atatcacggt gaattaacgg aggttgcaaa gcatgcatag cggcaactcc ttgagtaact 597121 tggctcatta tttgcaaaat ttcaaattca tgaagcctgt tttgtagcct tgtgttcata 597181 aaatcaatga gaccacctct ttcacaatat tccattaaga cgaatacttc atacgaacca 597241 ttatgtaaca ttgccttagc tgcatgagaa tcaatgtaag atacaacata cctattgttt 597301 ttcagcaacc tcatagcatc tacttcagct cttaaagtgt ttagactagg tttgtctgga 597361 acaatgactc tttttaagca tgcaacgctt gaattagaat gtgggtcagg tgggttgatt 597421 aacgcggaat atacttgagc gaacccaccg cttgttagat atttaatgat ctcaacctga 597481 tgtgacccaa ctgttaactg tgtacctaca ttgtaagtgc caatttgagg ttgattcatg 597541 ttgatttatc tggttgctta aaatacctaa ttatgcagag taatatttct ttctcaggga 597601 aagaagttgg caaagaaaat ataggaccac gaaggagaaa caattagcac ttttaggatg 597661 tttccttggc ctattcttat tttattatca tgaaaaaatt attttttctg cacgttgatt 597721 taccaaaaga atagttaaat caacaaggct tagaattcgg accctattgc tgcgaggcga 597781 aagagggcta tgcataaaca tgagttcgaa ataacccgta aatcataaac aaacctaaat 597841 aagccgtggt tagcggcctt ttttcgttat taccccaaga taaatgtgca gctcttgtaa 597901 gctcagcata catacttgtt gagtgtgtca ggaactgttt tcaggaaccc aaggttgaag 597961 tgttaaaatt aagaagctgg attgtgctct ccatattaaa tgaagcgtag ttacaaatcg 598021 ttggcatgga gaagtttgcc tcgtgtttac atttacaata ctaaatagtt gtactgaggt 598081 ttgacgaata taagggagta aggagcgcat cgtgtttctc tcttcaagtt aatactatgg 598141 agaccttggc catttgaaag tactataaaa agccactgaa gtagtatcat tcccggctgc 598201 ttccaagttg gcgagccgca agactcaatg ccgctgtata tttttactgg gaaacaggtt 598261 tgagtgttca cagattgaaa tttttattaa gacctattaa gtgaaatact gacagatact 598321 atgtacatgt aggggtaagt tggtgtatgg tgtgtacagc caggagcagc tccatctata 598381 gcaagcttga agagtacata tggacgctta gtaacgtctg gttaggccgg tctctcgata 598441 aaaccgcgaa cccgtttctt tccccctgcc agtcctctct gttaagagtt gaagccagtt 598501 tagtgatgcc gcccagtact tctatcgtat aatctccaaa aagtgtgtat agttcgctta 598561 cagagggcat tttcgatgaa atatccgcga accccaaggc gctcactgat ccagcatcta 598621 aaatcgaaat actcccatgg ttgtggtggg atagcgagtc cagagtgtac tggtcaaagc 598681 atatctctgt agacaaatcg tggaatggca ctatcgagtt ttctccgacg gtcatgagta 598741 gacatttctg ccggttgctt ccttcgaacg ggtacactag tttctgagtg atatccattt 598801 tagtaaaagc tttcccgaca ccctttccga agattctgcc gaccatttcc ccaaatccca 598861 gtcctaccat tttttccata tcagcatcgc tattcagctt attttcctgc agatacttca 598921 gaagatagcc ccaagcggtg agtagtagga caataaagtt cagcgcacaa gaagttattt 598981 tcaaaggacc cttccactta aatggtgcgc agttgaaaag aaactgcatg gtttgaatta 599041 tgttagtagc agtattcaaa gcggtttccg ctttgttttg tggttgcggt gcggcagtca 599101 cagttgtgat ttcggtgatt gttgacgtag taaatacagt tgttacatcg accgagtgac 599161 aaagtacggt tagggaggta accaacgcaa ggaaaaggac ggttgtcctt gattctctgg 599221 agtaaagcat aatctcgcgc acgctcttgc tattgacagc ctcgttgtat caacttgtgt 599281 ttaggaaagg aggcagaata aagattaaaa atggaagaaa agactcaatg gttccagcga 599341 aacaaagatg tttgaaaaaa aaaataattc agaaacgagt ctcttgtcag gaaagcagtg 599401 tcaggaaaac agtgtctgtt ctatagtttg tgttgtgtcc ttcaagcact tttggtgtta 599461 aaaaaccttg ctaaagtttt gtacaggttt ataccgttgt gcaaaaactg ctgctaggat 599521 aactgaacag ttgtttctgt ggcagatgtt gtgaataggc gcctttattt taagggtcca 599581 gtgatccgcg atgtgaataa atacgcgcgc ctctctcgaa ggaaccttct ggggctgctt 599641 ctgtcgataa gaaagcttgg caaaggcctt acttggcatt taagtaaagc ctttgcttta 599701 ctgcttcttt cccgcctttt tggtgcattg ggttaattga tgaatatgcg taaaatttaa 599761 atcagactat gaaaacatat ataacaacta ttacaagaga ggtggtagtc tacttgaaga 599821 ggcgcgccag aagaaaacgg tggtaagtac gaagttatgt gtagactaac ttgcttgtta 599881 aaaagtattt ggtcagccgt gccaaacagt tcgaactatc agaacttctg acggttcact 599941 gatgtacaaa agttgagagc cattttcgta accagctttt tgtcccacgc tcagaaggat 600001 gcattggtac ggtcacttcg atattccttc tttgtgagtg gagccagagc tttttattag 600061 tttttagttc agttgctgtg cgagactcac gaacaagtag cagccggcat ggtttagatg 600121 gttctggcac ggtaagctga ggagcgctat tattattgcg ggtactacag tcattagaag 600181 atggaatgga ttccttgcat atgtctatca gtgcctgaaa cgccctctca atgagggagg 600241 tgtcaggact caaaattaag gattgttcgg cgggatgcgg taagccttcg tatactaggt 600301 tgttggacgg aaaaatctga tacggcttga tctgaatgtt aggatcgacc ttactgtcta 600361 aagtatcgag agtgatgttt ccttttcggt ttaaagactt cttctcgccg acatcgagag 600421 aaaaatgaat gtgatcaaga accagatcta tttctctttg tgtgtttttc cagggacaag 600481 aaatggagta gggctcaatc ctctggaaac cttcgtattt gtattggtat gaataaaaac 600541 ggcactctgc ttcctccata agttggtcgt agctgggcat tgtatcgaag ttgaagggtc 600601 tcttccagaa tggaatactt ttatttgaag ggttgtagta ccttctgggc tcagattgtt 600661 cgtctaaaag caggtattga acagctatca tcttgcgctc aaatttaaat tcgagggaat 600721 cgtagtcaat gttctttgta cttctcagaa agagtggaca gtattttccc attttgcttt 600781 caaaccagtt ctgtggcctg tcaaggtact gttgcatgta tgaaggaact acagtagtca 600841 acgtgtggtt agactgggaa aattccgctg tggacacgac gctgcagctt atattttgat 600901 tgcagggagc aggagcgcag gcatcttgtt tagattttcg gcttggataa tgtttgtggt 600961 gatcagtgga atttgttggg cagtaaattt cagttggaat gatagattca ttcgtctctt 601021 ttgttctgga gtccttggtg cggcggaaat caaagcaagt cacttctgcg ttaagcgatg 601081 cgaaattgcc gtctggaaat gacgatatgt gtggagaatg aggaggattc catgacgaat 601141 aaactgatga ggatgtgcta acagatgagg ttagtgaggg taccgattcg ttgttttctg 601201 atgcagagtc tgttgtggga gatgtggtag cgttatttct ttgcacaaga gaagatggga 601261 gcatagcacg gttgtgggag gaggaagaaa acatcacgtt gcaagtatcg tttacggagt 601321 gggataagag gtaggaggtt gtcatagcgg tgctttcttc ctgatgcatg gcagaagaag 601381 ttggcagtaa ttcgtttatt atggtgacat tgtcgtgatt agaaaggact gtctctttta 601441 ccattgcctc gggtatgttt tttggcgcct gccttgaact tactccagaa caagcctcag 601501 cagaagaatg accggaatga ttcctcttat acacgttcca gagtggagca ttcttgacat 601561 cataaaaaaa gttgctgaca ggatctttgg actggttgac gttaagtggt tccgtagctg 601621 gtctgatgtt ttcttgtacg gtatcactga cggctgagaa accttcagag gaaccgtttt 601681 cgggaacaga cttggaggat tgcaaattaa gccattgaaa gtctagccca accttgttgc 601741 agaaggcctt gaactcctgg aaagatgtag acattatgtg ggcgaaaaac aaaattagac 601801 caacgcttta gcaaattttt tcaacctcaa attgatattt gaagattaga tcggatggtt 601861 ttttttcctg tggtgtaggc caagcttaaa caaggtttta agtgaaagtg gaaataattg 601921 tgataaacat gcggaaagag tgccagcctt aaataattcc gcattgttgc tatgtcgttt 601981 tgtttttgtt tttgttttcg tcttattggt atttgttcat tttacgacca caaaggatcc 602041 agggcttcta cttgcacagg gagggttgct tggttaatac aatgcaaagg tcagagatat 602101 taagatttgt gaagggtgca ttcaatgagt ttttccttta atgtgcccta gaaaggaagt 602161 agtacgaaca tttctcagtc ggagtttgcc ggaaattcga atgacagtgt aagttgattt 602221 ttgtggcaca gagataatga gcggtggttc tggcacacat ttgtgacgtt ggtttgatag 602281 tgtggaggga gggtgaaaaa cagataacaa tggtctcttg gcccagttgg ttaaggcacc 602341 gtgctaataa cgcggggatc agcggttcga tcccgctaga gaccattctt tttttacatt 602401 tctcgcaatg tgatttattt tgcttaccct tcccactgcc gttacaaggg aggtgaacga 602461 agaggcttgt tagcataagg tttacgcgtt gcggttgtaa gcacaatgtt cttactaaac 602521 ctctgaagat taattatcct aacgtatact aattaattca aagagaatat ttactcgttc 602581 tcttttcatc attttgtaac ataattcttt acgtattttc acttcgtact tttttcaact 602641 ttttttgcct tcgcttcttt tttgttgtaa tttttcaatt tttttttttc atcgttggcc 602701 gtctttcctt gtccttcatt ttcctctcgt aataatcatt caactacggt aaagcatgcc 602761 tttccttttt tctactctgc agttattttc ataatatcta ctgtttccat ttcgtgcttt 602821 aagttagagt ttaatcttcc cttctatcat cttaatagca ggttcataat aagaagatta 602881 ccacatctac tctttgttcg attccaatgt ctgaaaataa cgaagaacaa catcaacaac 602941 aacaacaaca gcaacctgtt gccgtcgaaa ctccctcggc agttgaagct ccagcatcag 603001 cagatccttc ttctgaacag agcgtcgctg tcgaaggcaa ttctgaacaa gctgaagaca 603061 atcagggtga aaatgatcct tccgtagttc ctgctaatgc tattaccggt ggtagggaaa 603121 cttccgatag agttttatat gttggtaacc tagacaaagc tatcaccgaa gacattttaa 603181 agcaatattt ccaagttggc ggaccaattg ctaacatcaa aatcatgatc gataagaata 603241 ataagaacgt caattacgct tttgttgaat accatcaatc tcacgatgcc aatattgcct 603301 tacaaacatt gaacggcaaa caaattgaaa acaacattgt caaaatcaac tgggccttcc 603361 aatcccaaca gagttcctcc gatgatacat ttaacttgtt tgtcggtgat ttgaatgtta 603421 atgttgatga cgaaacttta aggaatgcct tcaaagactt cccatcctac ttgagtggtc 603481 atgttatgtg ggacatgcaa actggtagtt caagaggtta cggttttgtt tcctttactt 603541 ctcaagatga tgcacaaaat gccatggaca gcatgcaagg tcaagatttg aatggtagac 603601 cgctaagaat caactgggct gctaagcgtg ataacaataa caataataat tatcaacagc 603661 gtcgtaacta cggtaacaac aaccgtggtg gtttccgtca atataacagt aacaacaata 603721 acaacatgaa tatggggatg aatatgaaca tgaatatgaa tatgaacaac agcaggggca 603781 tgccaccaag ttcaatggga atgccaattg gcgccatgcc attaccatct caaggccaac 603841 cccaacaatc ccagaccatt ggtttacctc ctcaagtaaa tcctcaagct gttgaccaca 603901 tcattagaag tgccccacca agagttacta ctgcctatat cggtaatatt ccgcactttg 603961 ccactgaagc tgatttaatt ccgttgttcc agaacttcgg ttttatttta gatttcaagc 604021 actatccaga aaagggctgt tgcttcataa agtatgacac tcatgaacag gccgctgttt 604081 gtattgttgc cttggcaaac ttcccatttc aaggcagaaa cttgagaacc ggttggggta 604141 aggaaagatc aaattttatg ccacagcagc agcaacaggg cggtcagcca cttataatga 604201 atgaccaaca acaaccggtt atgtctgagc aacaacagca acagcagcaa cagcagcaac 604261 aacaataaat attatgaaga aaagtggaat gaaacaaaaa gaaagaataa agagaggcaa 604321 cctacaaatc ccaagataaa ataaaaaaag aacgacaaga atccattcat tatattatac 604381 tatttttaaa aaaaaaatta ctacgaaaaa gggagagaaa aagaagaaga aactcaattt 604441 actattgctc gaaaaataaa agggcctata aacttactct atttttttag tttttctgtg 604501 tcttatttcc ttccttcgtc actgtttaat ttttaatact attattttcc tttaaaatgt 604561 gaaagtcatt gctaatagtg tgataaaaat aaagaacgta ttttctgaag gctttcttta 604621 ttatatttcc tttttccttt cttaccctat tttttttaaa catccatccc actgtatttt 604681 gtcgagtcca tatatataat ttttgttttt attttttaca acttttgtta agtatataaa 604741 aatgctacct agcgttatgg agacatgtca gtcttgagtc caggcacata aaggcaacag 604801 ccactaccac tgcgcacccg tgacgctgct ccaacgttct cattaagtac ggaactgtgt 604861 ttcgaacaaa agaatggctg ttaagaccaa aaaaaaggca gcttaacagg aacccggctg 604921 gttccacagg acttttcttt ctttagggaa aggttgtgaa aatgacaacc aaaaagtcgc 604981 gacgccaaat atcaaaaacc tagatgatat tacttcgtct gccaaacacc tcctttccct 605041 ctatccagcc cttatttttt ttccaagagc ttcatatgca cgcccgaatc atttcgaatc 605101 gcgtacgtgg caggttgtgg ctggcatctt tcccaaaagg aaacggacca ataccacgca 605161 tccccgagct cttggtcttt ctttatcttg catagcccaa aaaataaaat ggggcgggaa 605221 aaagggggca tatcagagca tcgggaactt ctttcaatgc aatatatatg gcacatataa 605281 aaaattctgg cttcattatg ttaggtgcag agattccgtt tagaccaatt gaacggtaac 605341 cagaaggtaa tcttaaatat acaaacaaaa aacaaggtcc ataatgacaa agaatttcat 605401 cgtcactttg aaaaagaaca ctccagatgt ggaagctaag aagttcttgg attcagttca 605461 tcacgcaggt ggctctattg tacacgaatt cgacatcatt aaagggtaca ccatcaaggt 605521 accagatgtt ctccacttga acaagttgaa ggaaaagcac aatgatgtca tcgagaacgt 605581 cgaagaagac aaagaagttc atacaaattg attcctgaga taaacgcaaa cactttttta 605641 ctcggaaatt ttctctcccc gattgtaaat ttatttctcg tctactataa taattcacca 605701 aaaaacagca gagcacgtcc tatatatata tatatatata tatatatata tacatatata 605761 tatacgaata tatttatgac agtctaaatc gttgctcctg ttcaatttta acgctctttt 605821 ataactgctg tggcgccatt tctttggcat ctaagatgtg tctcgggact ttctttttct 605881 ggtcatcttg ctttccttgc cttgtcatta acagagctaa actgtgttga ggaagtggtc 605941 ttttaaattt tcaaggtcgc ggcccgtgca ttgcgcggct ggatgtcttt taggggagcg 606001 atgcgcttgc acaaaagaat agccttgatt tccgctatta atgggtatat tcttctaaca 606061 atttgagttt tttctccact tgtttctttc ttctttctct tttccattca cattttgctt 606121 tacttttctg gataatatat atgtgcatat atatatatcc atttaaatat atatatatat 606181 atatcttttg tcctcctctc cagttacttt tgcgccagaa attccttctt cttttcaatc 606241 taatagagaa gggtagatag tgtggtgcaa aaaaagagcc ttttaaacca aaaataaata 606301 aaaaaaagga atcacaaaat gtcagattca caacaatcaa tcaccgttct agaagagctt 606361 ttccgaaagt tggaaactgc tacttcagaa acaagagagg gtatttcttc ggagctttcc 606421 tcatttttaa acgggaacat catcgagcat gacgttcccg aagttttttt tgatgaattt 606481 caaaaagcta tccagagtaa acaaaaggcg ctcaacacgc tgggtgcggt ggcttacata 606541 gcaaatgaaa ctaatctatc accttctgtt gaaccgtaca tagttgcgac ggtcccttct 606601 gtatgcagta aagctggtag taaagataat gatgttcaac ttgcggcaac aaaggccctc 606661 aaagccatcg ctagtgctgt taacccggtt gccgttaaag cactcttacc tcatttgatt 606721 cattcgctgg aaactagcaa caagtggaaa gagaaggttg ctgttctcga agtaatctct 606781 gtattggtag atgccgctaa agaacagatt gccttaagaa tgccggaact aattcccgtt 606841 ctttcggaat ccatgtggga cactaagaaa ggagttaagg aggcggcaac gacaaccatc 606901 acaaaggcaa ctgaaactgt tgataataag gatattgaga gatttattcc aaaattaatc 606961 gaatgtattg caaatccaaa tgaggtgcct gaaaccgttc atctcttggg tgcaactact 607021 tttgtagccg aagtaactcc agcgactttg tctattatgg ttcctttatt gagcagaggt 607081 ttagccgaga gagaaacctc tataaaacgt aaagctgcgg ttattatcga taatatgtgt 607141 aaattggttg aagacccgca agttgttgct ccattcttag gtaaactact accagggcta 607201 aagaacaatt ttgctactat tgctgatcct gaagcgcgtg aagttacatt aaaagcttta 607261 aaaaccctga gacgtgtggg taatgtcggg gaagatgatg tgttaccaga aatatcgcat 607321 gctggtgatg tttccacaac actgggcgtc atcaaggaat tactggaacc tgaaaaagtg 607381 gccccaaggt tcaccattgt ggttgagtac atagccgcga ttgccgcaaa tctaattgat 607441 gaaaggatca ttgatcagca aacgtggttt acacatgtta caccttatat gactatattt 607501 ttacatgaga aaactgcaaa ggaaatacta gacgatttca ggaaaagggc agtagataat 607561 attccagttg gaccgaattt ccaagacgaa gaggatgagg gtgaagattt gtgtaattgt 607621 gaattttcct tggcatatgg tgccaaaata ttactaaaca agactcaatt gaggttgaag 607681 cgaggtagga gatatggtct atgtggtcct aatggtgccg gaaaatccac tctaatgcga 607741 tccattgcta atggccaagt tgacgggttc cccactcagg atgaatgtcg cactgtttat 607801 gtggaacacg atatcgataa tacacattcg gacatgtccg ttttagattt tgtatattcc 607861 ggcaatgtag gaactaagga tgttattacc tcgaaattaa aggagtttgg gttcagcgat 607921 gaaatgatag aaatgccaat tgcatcccta tctggaggtt ggaaaatgaa attagctttg 607981 gcgagggctg ttctgaagga cgctgacatt ctactattgg atgaaccaac aaatcatcta 608041 gacactgtta atgtggagtg gctggtaaat tatttgaata cttgcggaat tacatcggtg 608101 attgtctctc atgattctgg ttttctggat aaggtttgtc aatacatcat acattatgag 608161 ggtcttaaat taagaaagta caagggtaat ttatcagaat ttgttcaaaa atgtcctacg 608221 gcacaatcat actatgaatt aggtgcctct gaccttgaat ttcaattccc aactcctggt 608281 tatctagaag gtgtcaaaac gaagcaaaag gcaattgtta aagtaagtaa tatgactttt 608341 caatatccag ggacaactaa accacaagtc tcagatgtta ctttccagtg ttctctatcc 608401 tcaaggattg cagttatcgg acctaatggg gctggtaagt ccactttaat taatgttctt 608461 actggtgaac tgttaccaac cagcggtgaa gtatatacac acgagaattg tcgtatagcg 608521 tatattaagc agcacgcttt tgcacacatt gaatcgcact tagacaaaac tccatccgaa 608581 tacattcaat ggaggttcca aactggtgag gatagggaaa caatggatag agcaaatagg 608641 caaataaatg aaaatgacgc agaggccatg aataaaatat ttaaaattga agggacccca 608701 agaagggttg caggaatcca ttcaagaagg aaatttaaaa acacgtatga gtacgaatgt 608761 tcgtttttgt taggtgagaa cattggtatg aaatctgaaa gatgggttcc aatgatgtct 608821 gtcgacaatg cttggctacc aaggggcgaa ttgattgaat cccattctaa aatggttgct 608881 gaaattgata tgaaggaagc tttggcttct ggtcaattca gggctttaac aagaaaagag 608941 attgaattac attgcgccat gttggggttg gattcagaat tagtctcaca ttcaagaatt 609001 agaggtttat cgggtgggca aaaggttaaa ttggtactcg ctgcctgcac gtggcaaaga 609061 ccccatttga ttgttttaga tgaacctacg aattacttgg acagagattc attgggtgct 609121 ctttcaaaag cattaaaagc ttttgaaggt ggtgtcatta ttattacgca ttcggcagaa 609181 tttactaaga atctgactga cgaagtttgg gcggttaagg atgggaaaat gacaccctct 609241 ggccataatt gggttgcagg acaaggtgct ggcccaagaa ttgagaaaaa agaagaagag 609301 ggtgataaat ttgatgctat gggtaacaag attaatagtg ggaagaaaaa aagcaaactc 609361 tcttctgcag aattgagaaa gaaaaagaag gagagaatga agaagaaaaa agagatgggt 609421 gatgaatacg tttcttctga tgaagatttt taatttgaag tcgagtacat ctctttcagt 609481 gagtaactta tatatttttg aagttaacat ccttattctt tttttatatt tttatttttt 609541 ttatgtttat tttctattac tgattttcac aaagaaaggt aaaaaaaaac atacttcagc 609601 ggctatacaa ccatatttaa gtaaatgcac tcagagaaag tatacaagta aaaaacctaa 609661 gtaaagacat aaatatccca aaataatgca aaaactcctc tttgtctttt ctgtgttatt 609721 gacagtagta ctagcaacag caccatttca ggtacaatgt cctagctctc cacttattag 609781 ggaggccaaa gtaagttaaa ctctttgcca ctttaacaaa tatgggccaa aactaaccga 609841 atataccaaa acttcgtatt cctttgttta ttagcatgaa ctctgtccag aagaaacctt 609901 gtatctgaag aaaaaaaaaa ttaaaacgaa gaataaactg attcagtttt taaaatcctt 609961 gacagaggca aagtttagtt cgaagtttta taaacgcgtg ttgaaagatc ctccaaaaat 610021 tgggattgct atatctggcg gcgggtacag atccatgtta gtaggtaccg gatttatttc 610081 ccaaatgaac gattatggcc tttttgaata ttcggattat attgctggat tatcaggcgg 610141 aagttggatc ttgatggatt tggtagttca aaattttgaa gtaaaatccc tgctacaaga 610201 gtgggacctt gaagaggatc ttttattagg cataccggaa ttcgatattt ccgaagaaga 610261 aattgttacc aatgcaaaaa aggagtataa tgataatgat ttgaagatga agaagcgtca 610321 ggggggttct ctgattacaa gctcttcaaa tttttatgaa caaatagagg agatcatgaa 610381 ttccatagaa gaaatcccag aagactatat gataacgaag agaaacttga atccattagc 610441 aagactaaaa aaaatattct ttcctaacaa cactttcact ggaactgatg cgaagattga 610501 aacctttaaa aaagtgctag acttttacaa aagtttgcat ttgaaaatta agcctaaaaa 610561 aatggagggt ttccaaatat cgttcaccga ttattggggt aaagcaatcg ttcaaagact 610621 aaaaaaaaat ttcgatgacg atcccaacca ttccttttcg ttttcgaagc ttgtaaactc 610681 gtctaaaaaa tttaaggaat gcagtgtgcc gatcccaata ttcgttgcaa attgcaaaaa 610741 tggacttctt tcaaacgtta tatttgaatt tacgcccttt gaatttggat cttgggaaaa 610801 tatcctcaga cttttcgtca agttgcccta tttgggctca aaaattgttt ctggaaaggc 610861 cgagaagtgt attaataact ttgatgatct aggttttatt actgcgacgt cttcttcaat 610921 attcaacaat gtgctcatct tcatctggaa tttggcttct cagtcctcca gagaagcaat 610981 gaaagctttg aatatggtta tgggaatttt tggcctaggt aaagaggaaa tatttagtat 611041 ttcgaaagac tcctcgagat tagagacaga ctatgccgta tatcaaccca atccctttta 611101 tctttatcct gaaaaagaca atgtcctaac taacaaaaat catttatacc ttgtagacgg 611161 cggagaagac ggcgagaata ttccactcag aacattggtg attcctgaaa gggaactaga 611221 tgtaattttt gttctggatt ctagttcgga tattgacaac tatccaaacg gctccaagtt 611281 aaaaaggata ttcgaaaaat tagatgaaga gaacgttcat taccaatttc cgaacaatgt 611341 aaaaacattc actcacccca ttgttatagg atgcaatgct accaaaagaa ctggacatga 611401 ttcatttttg ccaattataa tttatcatgc caatgcgaat catggaaacg catctaatac 611461 gtcgacattc aaaataactt acaatcagtc tgaagttagc agtatgttac ccactggaag 611521 gggagtgttt agcaatgatt atgaccttta ttataaaaat tgcttaggct gtatattaac 611581 caaaagaaca atggacaggc tcccaagaaa aaagaaattt tcgccatttt gcttacaatg 611641 ctttaaagac tactgttact cataagagag tagacttttt ctgtgaaatt taatgagttt 611701 ttgttcacct tttttacttt tcttctatgc catatggtta aataaaacat ggttcaaacg 611761 cgattctttt ttattatcta tgtctttatt atgtagtctt cactataata accgttaatg 611821 agcgacatag ttgcatcagt ttttaaggcc aatttgattc agaacctttt caagttcttc 611881 actttccatc ttatccgaag acgcgatctg gtggcatcta atactatgct tctcgaatat 611941 cgtttcatca atttcaattt caccattttt taggtaaaca atatcagtaa taaaatcttg 612001 ccattcaaag tcatcattct ctgaatggac acccttagat tgcctatagc ctgctattgc 612061 cctactcata gaatctatga tcatttgaac gtagtgtaaa ccgtctaaac caaaaacctc 612121 tctatcatat ttattattta tgagcaaaac ttttttcgta ttattagatt ccaaaattac 612181 ttcagcaaga ttaccaagaa taaggattgg gagtaaactt gtcattaaag aaccgataga 612241 ataaacgacc atgtcagctt ttttcacctt ggaaatagct cttggatttc ccattggttt 612301 tatctcttcg ccatatgggt ttatatacaa tatcctatgt accggagcag gtagattctg 612361 tgattcatca agcttgtcaa aatgcaactg ggagtttttc agttctggaa gaatatagat 612421 aggattggca tactcctctt ccgcttcttc ttcctcatcg tcgaggagaa ttttcaaatg 612481 gtcgtcataa gagccaagta aatgaataaa tttagctgaa tgtgctatgc tattatcttt 612541 aggaacagat ttcgagggat gcgatatttg tgattggcca gttatcatct caccattcgt 612601 caacaaagcc gagatatgat gtgtgtgatt ggtatttata catggaataa catgaactag 612661 aggactgcac cttcctatcc tcatcattag ttcaatagat gcgtctagag aacctaaaaa 612721 caatctagca ccagttaaga aaaaatttcc aatggatgca ctctcaaact gaaatggatt 612781 cgagtgtttg atttttttca agagttctgc ttgcatatgg ataataaaag aacgacacat 612841 ttccttaact tctatcgaaa tatttttcca tatgggatgc gaaccttcca ctatttcatt 612901 ccattctttc ttagctaata acttatcatt aggtagccta tggccaaaca actcgacaag 612961 ctgttcatct tgaagtagtc tcactattct agatctgata tcaccaattg ctgggccacc 613021 aactattcgt agaatttcac ttgtggaccc gccattatct gatattggca atatatacgt 613081 cagctcatgt ccttttaaga tagaaatatt agaaaagcaa ggagtcaatg aatttgtggc 613141 agtcccaccg gagcacacaa cgacgttcat ctagtaaact atctcaccac actctgctat 613201 tttgtcccct tattacctcg agggaacaaa agattccgtt tcctctcttt catagtccgc 613261 ctaaatagct taagaaataa acccaaacat cacacattag cgttctttag gaaatacgaa 613321 acaggttaat acaacagtag taactttcca cataatatct aagcattaca cgctgaaaaa 613381 aactctttat tggatatcaa caacccaaca cattgtacga catattcttt tatcgttcta 613441 ctatggtacc ctgttcaaat ctctttttct aaaatgagcg aaattttcga aaattatcgc 613501 ataatttttc atcatcttaa attaaaaaaa tacagtgtcc tctattgttt atctcaacag 613561 aacgcacaca ttcttgaaac ttgctcacat aacataagct ggagtgacat agcatttata 613621 tatatacaag ggaaatggtc aaagctgtta tttttaccga tttcgacggt accgttactt 613681 tggaagattc taacgattat ctgaccgata ctttaggttt cggtaaggaa aaaagattaa 613741 aggtcttcga aggcgtgtta gatgatacta agtcttttag gcaaggtttc atggaaatgc 613801 tggaatccat ccacacccct ttccctgagt gtatcaagat cttagaaaag aaaattcgat 613861 tggatcctgg tttcaaggat acattcgaat gggctcaaga aaatgatgtc cctgtcatcg 613921 ttgtttccag cggaatgaaa ccaattatca aggttttatt gaccagatta gttggacaag 613981 agtctattca caaaattgac attgtttcca atgaagtgga aatcgatgca catgatcaat 614041 ggaaaatcat ctataaggat gaaagtccct tcggacatga caaatccaga agtatcgatg 614101 cttataaaaa gaaatttgaa tctaccttga aagcaggtga acaaagaccc gtttactttt 614161 actgtggtga cggtgtttct gatctaagtg ctgcaaaaga atgtgatttg ctatttgcca 614221 aaagaggtaa agatttggtc acttattgta aaaaacaaaa cgtcccattc catgaattcg 614281 ataccttcaa agacatcttg gctagcatga aacaagttct ggctggtgaa aagacagtcg 614341 ctgaattgat ggaaaattag tgcaagactc ttacgaaata ttaaagttta ataccgtgta 614401 actgcctctt acatatgtat gcatatatac gtacgtacta tatttttctt gtatatcttt 614461 tttattgtct gagagaaaga acatcaaaaa ataaaggaag atcctcctcg gatttagcat 614521 gcttaatgcc gaatctttaa tacaaaacga atgatatttc aagtatacta attagaaatc 614581 aatcaaacat accaaaaggg acagtaaaga gaaaagcagg agctctcttt taggggaaaa 614641 gtaaaatgtg attagtattt cgttgcgtgt actagtcaac tcttcttgtc attcttaaat 614701 ttacattaat taccccaatt ttgcatcttc gtatataaga gtgttcccct tataagcttt 614761 ctcctgcaca tacctgcagt aaacacaagc aacactttag agatagttgt ccaagttaaa 614821 atgagtaaaa ttaaagttgt tcatcccatc gtggaaatgg acggtgatga gcagacaaga 614881 gttatttgga aacttatcaa agaaaaattg atattgccat atttagatgt ggatttaaaa 614941 tactatgacc tttcaatcca agagcgtgat aggactaatg atcaagtaac aaaggattct 615001 tcttatgcta ccctaaaata tggggttgct gtcaaatgtg ccactataac acccgatgag 615061 gcaagaatga aagaatttaa ccttaaagaa atgtggaaat ctccaaatgg aacaatcaga 615121 aacatcctag gtggaactgt atttagagaa cccatcatta ttccaaaaat acctcgtcta 615181 gtccctcact gggagaaacc tataattata ggccgtcatg cttttggtga ccaatatagg 615241 gctactgaca tcaagattaa aaaagcaggc aaactaaggt tacagtttag ctcagatgac 615301 ggtaaagaaa acatcgattt aaaggtttat gaatttccta aaagtggtgg gatcgcaatg 615361 gcaatgttta atacaaatga ttccattaaa gggttcgcaa aggcatcctt cgaattagct 615421 ctcaaaagaa aactaccgtt attctttaca accaaaaaca ctattctgaa aaattatgat 615481 aatcagttca aacaaatttt cgataatttg ttcgataaag aatataagga aaagtttcag 615541 gctttaaaaa taacgtacga gcatcgtttg attgatgata tggtagcaca gatgctaaaa 615601 tcaaagggcg ggtttataat cgccatgaag aattatgatg gcgatgtcca gtctgacatt 615661 gtggcacaag gatttgggtc tcttggttta atgacgtcca tattgattac acctgatggt 615721 aaaacgtttg aaagcgaggc tgcccatggt acggtgacca gacattttag aaaacatcaa 615781 agaggcgaag aaacatcaac aaattcaata gcctcaatat ttgcctggac aagggcaatt 615841 atacaaagag gaaaattaga caatacagat gatgttataa aatttggaaa cttactagaa 615901 aaggctactt tggacacagt tcaagtgggc ggaaaaatga ccaaggattt agcattgatg 615961 cttggaaaga ctaatagatc atcatatgta accacagaag agtttattga tgaagttgcc 616021 aagaggcttc aaaacatgat gctcagctcc aatgaagaca agaaaggtat gtgcaaacta 616081 taaaccaatc cgccattcat ttgaaaagac aagtctggcc tagggttata gtgttcagac 616141 ttgaggttga acatatccaa aaaaaaaaat tcctatgatg tcttaaatac gtatacctaa 616201 taaaataatt ctagactata ttcaacttac tgtaaccctt cacctcacta tcacagctga 616261 cgcatgtagc aaatccttta taacccagag atatcctaca atcatcgcat aatgcaaggc 616321 atctacaggg ccaagttaca atatttcttt tattaacttt gcagattagg caggagagat 616381 ccatttcctc cacttcgtcg caactatcaa aggcaaaatc aaacttgaac tctaatttgt 616441 catcgtcctt catatttaaa cgtttgtaca tatacctgga gtttgtatga tgcagaaggc 616501 gttcaataac aacatcgact agtacacctt gtgggtttct tttaccatat tgtgatctag 616561 tcaacggtcc attaacctta ttatggacat ccatttcata atttaaaata gaccacatgg 616621 agatgttcca ggctatttcc tctaaatcat cagaatcgac agcattactt gataaatgtg 616681 ttaattcttt ttcttcatca ataatcaact gactttccat atcactatca aactcttcat 616741 ctgaaacact ttcatcgatt tttctggggg gaaagtagtc ttttgatgaa tcgtcttcag 616801 gaagcaataa ctccaggctt ctgagatcac tctcaatatt aagctctttg acgtccggtt 616861 tatataaaaa ctttttatag tttttttctg taacatattt gtttaaatcc ctctttttac 616921 gctttcccac tctcggtttc ttatctatac tgctctcaaa atttttactc cacagaagat 616981 tttttaggag tctagaatac gtcaaaataa tggttcttac taattcaaaa aggcctaaat 617041 atgtcctcgc aaaacctggt aactgggaat cggtagtcat ttccttacga gataacagat 617101 cctctggtgt cgactggagt tggtttaaat gtccactaac cacataacta ttactgaaag 617161 cagcgacttc atcaacggat tttacgttgt ctgatttctt aaatatttta tagtcattcg 617221 acgttaaaag tagacacaat gaaagagcta tttcgttaaa ctcctcttct ccattgtaat 617281 tatttgatct ccaccatttt tccaagtttt tatatcttga atataatgat cggaacggat 617341 tactggtgaa caaagccttc aggaaaatgc ctatagacgc cagtaatatg gtggaaatat 617401 agaaaaagcc agggaaataa ttgtgaatga gacagatgtt aataaaatct aatccgttca 617461 aataggtcct agtgacgaat gcggtaaaaa aacccgcgtt taatataact tctccacata 617521 atctataggc tcttatatga aacaattcta ccaaatgaat tactaatctg tgaaaaaccg 617581 ctcctagtag ttcaacatta tcgccaatat gctgctgccc cgcgggcatt ttggatatga 617641 tataaagatt caatgataaa ccccatatgg aaaaatcaga gcatattaat gaaggaacgt 617701 tcgtcgttga agaaataaaa atttcaatgc agtcagacag agctacaaat aaatagacac 617761 ttaaagcata aaaatctgta tcactcacgt gcagttcatg catgagtcca aattgactca 617821 gaatttgtaa aagtgcttta accagtgaaa gagtggctac taaatggagc aaagtttttg 617881 accaaagagg taaacgaatg tttgtagaat ttgatctcaa tgaagacatt acagtcaacc 617941 tattcaaaat aatggcggta ctaaaacata gaacagcata cttacttacc gaataggaga 618001 aaaacattct aattcctacc ttagctagtt gcaaagtggt gaagttacct ttctccatca 618061 atgcttgaaa agagtccaaa gttggggctg aaactattgt agaatttgga cttacaaaaa 618121 cttccggttt ctgagttgtg ttatctaggt aattaagatt tccagtcttg ttgtgaaaaa 618181 agctaaatac atctctgtta tggagcaatt gcttaacatg ttgcaatata tttgtagaca 618241 tcagtcaaac ttttgaaaat ccctacgtaa tgactgttcc tgacaaattg tagcctctcg 618301 gtgaccttct gtcaagtcaa ccattcctta catacatcat ttatatgcca gagggcaggg 618361 taatgcagac atacaaaaac tttaatttac cgcgcaccgc accgcgcaat ttaagattat 618421 tgagtcaaaa ttaatgatgt atattatatg atttctgtgg tgataaattt atttgagttt 618481 ataattatat ttgcttagga ttactattaa aaattttcat ctatagcacg tttttgagcg 618541 tcgtttagtg atattggata gtccacttta tattttacaa tcaaattacc tctctgagat 618601 gggttctttg gagttggcat accttgacca ggataagtag aagtttgtga gggttggaca 618661 ggctgtactc tcgacaaagg taaggttctg ccatcaattg tttggatagt ttttgaaaaa 618721 cctaacaatg attccttgaa agatagtggc agagtgtaaa ttaggtcatc accgtctctt 618781 ttaaagtttg gatggctctt ttcctggatg acaaactgca aagtctttct acggcccgtt 618841 tgaggattgt aatcaccctg gttcttgtat gttattttgg taccagcttt ccaacccggt 618901 tttaattgaa tgtcaatttg tgtcttttca gaggccccat gtgggccctt tcttccaatt 618961 ttaaatgact tctttttacc aacaaacaaa tcttctagac taactggtaa attaacttga 619021 actgtttctt cctctggata cgtgggagag cttgatgctg atctaaagcc gccaggcata 619081 cctcccatgc cgccatgcat tcctcccatt cctccaggca tacctcccat accagcaccg 619141 ccgccagatg gataactaga gaaactgaag ccactgtcat cagcaccacc gaatggggaa 619201 ctgccgccaa agaattgtga aaaaatattg aaagcatcct cattactgaa cgcatgtcct 619261 ccggagaatc cgcccgcacc gccagggaag cctccagcac ctccagcacc gccaggacca 619321 ccaggaccaa agcttggacc accagatcta gcagcctcga gaccgtattg atcatatatt 619381 tccctttttt gaggatcatt taaaatttca aaggcctctg atatctcctt aaacttttct 619441 gtgtcacctg ttggcttatc tggatgatat tttagagctg cttttctata accctttttc 619501 agttcttgct cattagcact tggagatact ccaagtaaat cataaagttt tgtctccttg 619561 accattatta gttctgtata ctatactcta ttatattgat gtgaatgtat taaaaaaaaa 619621 atcttaaaat gcaaacaact tatcctttat cctctgaaga gtttctggat ggttatacaa 619681 ttctaagtcg ttaaaagaat tcgtgtaaga gcttaaataa tattaattag aatttttgac 619741 aagaaagcgc ataagtttaa aaagggatta acaatacggt aaagggacga gaaatctata 619801 caatatatat taaatctcga actaccttgg caaggagttt gtgctgacag tggttgaaaa 619861 acccgtaaaa ggatatccca ttctttttcc agaagtttct ggaacgttca tataaaccaa 619921 agagggtaac acaatacgtt aagattcaga aaagtaacga ctagctatta ctgatcatgt 619981 tatagaagag tgcgacaacc atatattatt agcgcagcga tcaacgtggc agtcttgtca 620041 tccatataaa aaaggagttc tgattgatgt ctgttatctt agtatctgct ggctatgacc 620101 acacaataag attttgggag gctcttactg gggtttgttc aagaacaatt cagcattccg 620161 actcacaggt taatcgctta gaaatcacca acgataaaaa gttgttggca acagcaggcc 620221 atcaaaacgt acggctttat gacattcgga cgacaaatcc caatccagta gcatcctttg 620281 agggtcatcg gggaaacgtt acctccgttt cttttcaaca ggacaacaga tggatggtga 620341 cctctagcga agatgggacc attaaagttt gggatgtgcg ttctccgtcc attcctagaa 620401 attacaaaca taacgcacca gtaaatgaag tcgtaattca tcctaaccaa ggcgagttga 620461 tatcttgtga tagagatggt aatataagaa tttgggactt aggagaaaat cagtgtaccc 620521 atcaattgac acctgaggac gatacctctc tccagtcttt atctatggca agtgatggtt 620581 cgatgttagc ggcagcaaat actaaaggta attgttacgt atgggaaatg ccaaatcata 620641 ctgacgcatc ccatctaaaa ccggtaacaa aattcagagc gcactccaca tatataacta 620701 gaattctact atcatctgat gtaaaacatt tggcaacatg ttcagcggat cacactgctc 620761 gtgtgtggtc gattgatgat gattttaagc tagaaacgac attggatggc caccaaaggt 620821 gggtttggga ttgcgcattt agtgctgaca gtgcgtatct agtaacggca tcgtccgatc 620881 attacgtgag attatgggat ttatcaacta gagaaattgt cagacagtac ggtggacacc 620941 acaagggagc tgtatgtgtc gcattaaacg atgtatagtt tacaatttat caactaccaa 621001 gcttgaagga ccgaagtgac aaaaaacatt atgattttca gtgtttgctt atccgccttt 621061 ttgtaaatat agattttact atcctgtgca ttttagttaa ttgattgttc acaaaatgaa 621121 agcaatcgcg atgcatatca tcaatgaaag gaagacgaga atgtacagta taaacatatt 621181 cccttgcatg tagcactaaa ttttaagttt cgtgtagacg aaaggtttag ctacttgcgc 621241 gacaaaatag taatatttac aggcattctt aaacatttta tatgtgtaca tactgtgcgt 621301 aaggaaagaa aatcaaagct tgctcaaaaa agcccgccta cttctagcaa tgacttcaac 621361 tttatttttg gtgtaatcaa aacgtctaga cacaattgac ttcttcccgc ttttggtttc 621421 aaccgtacta tctgtttcgg ggaagaccga ctttaagtat ttcctacgca aatgtacttc 621481 ttcagataaa gtcaaaaaat tacaagcgtc cttgaaaagc gccttaatat aattcttgtc 621541 ttttttggtt tctaagtgtt gggatttttc taggtcctct aatagttttg ccttcaaagc 621601 ttgtttttct tgttccgaaa tatactggtg tagctctagc ttgttattga aagatgtaga 621661 tgagttcaaa agatcactac actcatcaat cttggataga ctctccgaca atttctcatt 621721 cgtccagctt tctctccttg ccttcaaacg ctcttcttct tttaaataat atctactatt 621781 gaaccttgca tcttctatgg ggtatccatt cttcagggaa gcccttacac gaattaagta 621841 tgacgttgcc aattcgatgt cttttatatc taacttaagt tcatcccgaa gaaccttact 621901 caacttgtct tgtaactcct ttcttttaga ttccctgacc tctaactgct tcaaaatatt 621961 aggttttgcg agatagtctt ttctagaaat agaattttct tccttatatg ctgccctttt 622021 atttgttaac tcaaaacggc caaacctcct tacggtaggc tcaaaatgag gagatggcag 622081 tttcaaatca cgcctcaagg caacaccaat gaattttctt ttaggatgaa aaggatcaag 622141 atagtaacga acaacaccag gttctaaggc gaatatggaa tgatctttcc ctataccaac 622201 gttttctcca ggataaaact ttgttcctct ttgcctcata ataatttcac ctgtggaaac 622261 atcctggcct tcatattttt ttggtcctaa ccttcttcct gcagaatcct tcatacttgt 622321 tctcgagccc gcagcccttt tggtggcatt acgcacttga aggaacacac cagacacatg 622381 tttttggaat gaaaaactag aagtatctag taaaatagga ttccacatat tctcacctta 622441 ggttaagctt gaaatattat gaccacccaa actggcgagt tttattttta caatgagcca 622501 acttcattct tcagtgaact atcttgaatg agtctccaaa gaaagagctt taaaattcaa 622561 tagcggaacg tcagatatcg aaacacccag tcataacagc caaatttgca taattggtat 622621 aaaaacagtg tgtataacat tacagagaag ccgttgtgtg aaaatctttt tagtacctat 622681 tcaaccaaac aattgaactt gaacaccaaa ctctagccat ccttatcctc ttctggtcac 622741 tacatatacc tcaatttacg tctttccttg ggtcgtttca aatgactctc tttgtttagc 622801 gagggaaatg aaaaagtaga gtactggctg aaaaatttca taattatgtt tgctcatgag 622861 ttcgaaaaca gtttgaatga gcagatagaa cgccaaatat taagttaaca ggatatgtct 622921 gatcaagaac gaggttcaga aaacgtatgt ttcattgata agggaggtga agaaaagttt 622981 gtaaaatgag actttatgag gtcattggaa ttaaatagac atcaacgaat ggtgagtcac 623041 catttaatgc tgccttcaaa acgcttgctt caatgtgatt ccactggtta aagggggttt 623101 tttgaatgca ttgctaatgt ttatctactg gctatgaaag tgagaatatc aattataaat 623161 aaaaccctga ttttctacct gccatgctat aatgtacagt ttattccaac tttgaaacgc 623221 aatgacttat tggtctctct cattatgaaa tttagttact tttactaatg ttattcattg 623281 ttgtagaata atcgaagtag atcgaggtcg agatcacctg ttcgtcgtcg gatgagtgat 623341 gatcatggtt atgaaagaga caaccatttg tcccggaggt caggtaatta taacggtagg 623401 cgtaagttcg cagatacgta cagaggaagc agagatagag gagaatatag aggaggtaga 623461 gaaaggtctg attacagaga aagagaaagg ttcaataaca gagataatcc tagatctaga 623521 gaccgttacg atgataggcg cagaggaaga gatgtgactg gtcgttatgg gaacagacgt 623581 gatgactatc ctagaagctt taggagtaga cacaatacac gtgatgacag taggagaggc 623641 ggttttggta gtagtggagc aagaggtgat tacggtcctt tgttggcacg tgaattggat 623701 agtacatacg aagaaaaggt caatagaaac tattccaata gtatattcgt gggtaattta 623761 acatatgaca gcacccccga agatctcact gagttttttt cacagatagg aaaagtagtc 623821 cgcgcggata taattacatc aagagggcac cacagaggta tgggtacagt agagttcact 623881 aattcggatg atgttgacag ggccatccgc cagtacgatg gggccttctt catggatcgt 623941 aaaatcttcg tcaggcaaga taatccacca ccgtcaaaca atatcaagga aaggaaagca 624001 ctcgatagag gagagcttag acataaccga aaaacacatg aagttattgt aaaaaattta 624061 cctgcttccg ttaattggca ggctttgaaa gacatattca aggaatgtgg gaatgtcgca 624121 cacgctgatg tggaattgga tggcgatgga gtatccactg gatctggtac ggtgtccttt 624181 tatgatatta aagatctgca tagagcgatt gagaaataca acggttatag tatagagggt 624241 aacgtcttgg atgtcaagtc taaggaaagc gtacataacc acagtgatgg agacgatgtt 624301 gatatcccaa tggatgattc tcccgttaac gaagaagctc gaaaatttac cgaaaacgtt 624361 gtcggtggag gtgaaagaaa tagactcata tattgcagta atttgccatt ttcaactgca 624421 aaaagtgatc tttacgacct tttcgagaca atcggaaagg ttaacaatgc tgaattaagg 624481 tatgattcca aaggggcacc aactggaata gctgtcgttg aatacgataa cgtcgatgat 624541 gcagatgttt gtattgaaag attgaataat tataactatg ggggttgtga tttggatata 624601 tcgtacgcta aacgcctcta gaactactct cgatctatat actttctcac ctattggatc 624661 tgcgacaagt atttattcat tcttgactta tttccaggct ttttaacttt ataatgtcat 624721 tgtgtatacg tataatctga aaaaatttcg aagactttga agaagactgt gaaaagagtc 624781 tgatttttcc aatacagtga aaatgggttt aacaaatatc caaaaaagta ctttgaacag 624841 atatcgtaaa tagacgactt ttttatatga ataacaaaaa ataaacaaca gacaagaggc 624901 ctcagaaggc ttacgtaaag tacgtaaacg atctacctct tacaactggt agttgctttt 624961 gctctatgtt ttcattacgc tctcatttct ccagccgttg ggaaactttt cgataataac 625021 gaatgaacag tttcatacat gcctaggaag atagcaccac ctgcactgat ccacattgtc 625081 cggggcccca ctccactgaa aaatacagca ggaccttcct ctctgtaaat cctaataata 625141 acgcttccaa gtgaggcggt tgttttgttg agcattaatc tggttttcaa gaaatctaat 625201 ggtgtcgttg tagctgctgc gatcccaccc gcaatagaac cgcagatagc ccctttccat 625261 ggctccactt gactttggcc attggctttt gcccaagtct tttttagata ctcgtataaa 625321 ggaaactgta tacaagtaaa cggtatttct ctcataatgg tggtagacca ccctctataa 625381 agatttttcc ttaaaccttc cttattgtca tttcgtagaa ttgactgtaa agtctgccag 625441 gaagaattgg tagagtgaac ttgcgtcctt tgcttaacga cttctgcggg aactcgaaca 625501 agacaagcac aaatttcacc aatggaagag gaaagcatgt gcgttgtcgt atcaatcaat 625561 tgctcagatc cctgtgagta aagtttgctg atatatggcc ttgattttac tttcatataa 625621 tcataactaa taaagaaaag tgaagcacct ggcgccgatg ctacaacagc gcttcccaaa 625681 ccacgatata tgcctttgta tcctccatta gcaaagaatc cacccttagc ttgaagcctg 625741 gttttaattg tgtctatagg gaaaaaaacc aaatccgtag aggtaccagc agcggcgcca 625801 cttagcaagg aaagaaaaaa agtattcata gcaaactttt caaagcgaat tttagttcat 625861 cggtgtgtct aaacatataa aatcgccaaa caatttacaa caagtggagc tttaatgatc 625921 tcatatattc tcgagggtgc accccactgc aaatgtattt atatacaaaa cagcgctcag 625981 taagcgagga aaaaaagagg cgcccgtgct tttgccgata cataaactaa aaaccaataa 626041 acttgccaaa atacgtatat tcttcaatcc atgaggcacc actaattata tgcaaaagct 626101 caatatctgc tccttcaatg gcattagata actaacaacc tatgtactat acaattttaa 626161 aatactctct taattaattc aacttggcta ataaagagtc aatgtcaact tcgataactg 626221 gtgctgtagc tgcatttgaa aattgacgag ttcttgattc agcctcccgc tgttttattt 626281 tccttagcct attcaaagaa ccaaatccag atacttctct attcaacttg aatggttgta 626341 agaagaagtt acaaacagaa aaagactcac ccatagtggc aatctcatga ataatatctt 626401 caacacaaat tattccatga tctcctaatt gctcctcgac aatattgttg tcattaagaa 626461 ctatttcgtg aggttcagcc tcattctcac ccttatagat tattctacct ctcttttgaa 626521 tcaaggaacg gatagaagat aaagaaggct tgccaatcac tacgtatggc gcaataacct 626581 tgagcaacgg atatacgttt ttggtcaatt tgacgaaaac accagtatta gtttcaacta 626641 atcttagcaa agacaaaatc ttaaatgctt tgtttggaat atttacagca agcggacctc 626701 ttactctgac aatgaaaagt aaagcaggtt tgccatcgta agtagtcttt tctctgatta 626761 aaccatcgtc ttcttcttct tcagtctcct ccaagtcgac agagttctct tcggcgccat 626821 tagctttttc tgttattttc agaataaaat ctttcccaga tgcaatatgc tgcgtttcat 626881 tctttgcctt cttatcttct aatatagaca ctcttttaat tctttccttt tccctagagg 626941 tagccaaagt ctttgcaact atactttcag ctctgacaaa tttgttctta ttacttctct 627001 tttttttgat ttgttcttcc ctctttttct tagctaattc ttgtctttcg attctagttc 627061 tatcagcatt tcttcttttc ctcaaaagaa tttctggatt agaattaaga gtttgcgctt 627121 tactgtcttg agttgaagac attgtgactt gtatatctta ttctttttcc ctgtggcagc 627181 ctcttctttc taggaactta ataacgaaag taccaaacaa cttagacttt tctcatctca 627241 tcgcttccca gcttttttta agcagagctg aaaaaaattt tctttttacc aaaaatccgt 627301 actgcgtgat gaaagtgtac atacattatt caatattcac ctagttttgt atattaatgt 627361 aaaatgtaat ttaatgaaga tcccaaaaaa ttaagcattc gttgctgcat cgttgtcatt 627421 ttgttcaatt atcgcattcc tatcatagca aaaatatgaa ggttattagt ctgaaaaagg 627481 attcttttaa caaaggagga gcagtgatta ctcttttacc ggaggacaag gaagatctgt 627541 ttactgttta tcaaatagta gacaaagatg acgagttgat attcaagaaa aaattcacct 627601 ctaaacttga tgaagctggt aagaaaaaaa gtacagattt ggtcaagttg aagattaaag 627661 taatatccga ggattttgat atgaaggatg aatatttgaa atataaaggt gttactgtta 627721 cagatgaaag tggagctagt aatgttgaca tacctgtcgg caaatatttg agctttaccc 627781 ttgactacgt gtatcccttt actatcataa aacaaaactt taataaattc atgcaaaagc 627841 tcttaaatga agcctgtaat atcgagtata aatcagacac cgcggcggtc gttttacagg 627901 aagggatcgc ccatgtttgt ttagtgacat cctcctctac tattttaaaa caaaaaattg 627961 aatatagtat gccaaaaaag aaaaggacta ctgatgtact gaagtttgat gaaaaaactg 628021 agaaatttta taaagcaatt tacagtgcaa tgaagaaaga tttgaatttt gataaattaa 628081 agactattat tctttgctct ccaggtttct acgctaagat attaatggac aaaattttcc 628141 agtatgccga agaggaacac aataagaaaa tactcgataa caaaggaatg ttctttatag 628201 cccactgctc cacgggctac ttacagggca ttaatgaagt tttgaaaaat ccactatatg 628261 cttcaaagct gcaagatact aaatactcca aagaaatcat ggtgatggat gaatttttgt 628321 tgcatttaaa caaggatgat gataaagctt ggtatggtga aaaagaggta gttaaagcgg 628381 ctgagtatgg cgcaattagt tatttactgt taacagataa agttttgcat tcagacaata 628441 ttgcacaaag agaggaatat ttgaaactga tggactccgt agagagcaat ggaggaaaag 628501 cattggtatt aagtactttg cattctcttg gagaagaact tgatcaattg acgggtatag 628561 cctgtattct aaaatacccg ctccccgatc ttgatgaaga cgatggtgag gagtagattt 628621 actatgtaag aaaaaagtaa tgtacacata aaatttgcaa ccctataata aatcggatta 628681 ttctctttac ttcttcccta taagcaagta gatgtgaagc cgcaattaat tgagttgttg 628741 tgaaatggtt ctagttagtc acgtgcagct ttttaaaaat attttaaaac attttaaaaa 628801 atatacattt ttttattatt tttttatata ttaatgttaa aatttattta tgtatttgtc 628861 ttccgaaaag taaaataacg ttcaaatttg gtatttaagg atatctgcgt ttaggcgcct 628921 agcaaaaaaa tgccgaacta agaaattata ttaatgtggt ataagttact gtttactaaa 628981 agtgccccaa acggcgctgg actgataaga atgaatacgg attagacagc aggtttatgc 629041 taccctgctc ctagttttat gtgattaaac tcaaaacctt gctggtagaa atataaaaca 629101 ctgcttttaa ttagtataaa agtgacattt atcttgaggt aagaacagaa gaaaaaaagg 629161 aaaaagagaa aattttatga gattgctttt ttcacatgac catattatat tcgctttatc 629221 aactttttag tgtatcttct actctaggac agataaagat gcattaacct tgtcattttg 629281 cttcttctgc aggttcatat acatataaac gttagttaca ccttgacgta gtatatcgac 629341 tacaggctag attttactgc taaatcagcg cgccagccca ccacaattcg atttgaaagc 629401 gctttgcagg aatttaagag cattttgttt tctattcatt gatatcattt gccaagtata 629461 taacataacc ggtaggcata ggggactcaa agcgtaaaaa tcatgaagtc atagccattt 629521 ccttatgtaa tatatattta tataaattat aaactactca ttcgtatatg aaaatacgtg 629581 tttgaatagt cgcataccct gaatcaaaaa tcaaattttc cttagttctt actttcgatt 629641 ttctttacca actccttgta tttttcggtg gagaatgatt ttggcctttc gattggagca 629701 ccaacagccc tatcgatgat taattggggt aacacaccaa tagctctggc aacaccaaac 629761 aatacagtgt agaacgaagc ctcagttaga ccatagtatt gcaataaaac accggaatgt 629821 gaatcaacat ttggccatgg gttcttagtt ttaccatgct tagttaaaac ccctggggca 629881 acttcataaa tggtggagac caacttaaat aactcgtaat ctgggaaatg tttcaatgcg 629941 aattcacgtt gagccgtata acgaggatca gtttttctca aaaccgcatg gccataacca 630001 ggaacaactc tccctgcgtt caaagtatcc cacaagtact tttcaattgt ttcttttgaa 630061 tagtcacctt tcacttcttc tctcaattta aatagccatt ctaaaacttc ttgattggca 630121 cgaccatgta atgggccagc taaaccattc aaaccagcgg ccaaagataa gtatggcgaa 630181 gataaggcag aacccactaa atgtgtagta tgggcagaaa cgttaccacc ttcatgatca 630241 gaatgaatag ttaaatatag tctcattaag tcaataaaat ccttgttttc gtagcccaaa 630301 agttgggcca aatttttacc atagtcagca ttaggatcgg ttgaagtaat tttaccatcc 630361 ttgaacacat tacgataaat tttggaagca ataacaggta atttacccag cagatctaac 630421 gaatcttcaa atgtatagct ccaatattct ttcttggata caccttgagc atatgctttg 630481 gcaaacttag actcgctttc taaagcagtc acggcaatag aaaattgcgc cattggatgt 630541 agatcttttg ggaggctatc taaaagttgg ataacgtgct ctggaatttc tgatctggca 630601 gctaaatcag cagaaagggc tttaacttga gcgtcagtag gtatttcacc agtcaaaagc 630661 aaccaaaata aagcttctgg caaaggttct gtactaccct cagcctttgg tagttccctt 630721 tgaatttctg gaatagtacg acccctaaat ctaatacctt cttcggggtc taacacggaa 630781 ccttcccaaa caaggccttt aatacctctc ataccaccat aagcttgctc caaaagaact 630841 tcaccaataa cggttttacc gtgttctttc ttgaattttt taatttcttc tgcctttgct 630901 gggataattt cagcaaatct ctccttcaac gtttgttcgg aggcgctact atagtggcga 630961 gcattcaata gtgcaaaaag agccttttgc atattttgac attgtcttgt ggagcccctt 631021 gataagaaac ttttgctagt tgttgataat atcgctgaca tcttcgtaaa tagtattata 631081 ttgctatatg ttttgcctta ttttcttttt aatggttgta attgtaatta cttaaatgca 631141 aataaaagcc aaaacaaacc tggtttgtat tttagtaaac agcaaatttc ccccttaaga 631201 ctagcaatcc ataacagggg aagggtaaag aatagttgct gcaagttttg agcatttata 631261 taatggatgg atatcaattg acattttcaa acaacaagag gtcggataag tcgatagtat 631321 cggaaaagct ccaaagggat tgcgatcctc caataacaca aaagtatttt tggtctagcg 631381 ggggtcatac ttttcatttc cgggcggctg cggcggaaaa aaacgtgacg ccttttagca 631441 caaaaatgca aggtaaatac ataaaaaaaa aggcaatgtg aacgtaaaaa cgctcatatt 631501 tacaaagatt aattgagccg ttcaatgaaa tgcgaacttc ggagatttct ttaattagtt 631561 taggtatact ttcctgcgaa ggtcttgttg gaatatgtag taatctctac ccgcgttttt 631621 agttaatgct gaatggtttt tgatggctcc ttttttctta gagtgacagg cgcggcagcc 631681 ccttaacgcg ggtacctgaa caagtaaatc cgaaaattca atttgacaag ggaatcattg 631741 ggctgacaac aataagatga gctctcttat atttttgccc agggaaaaat tttttgccca 631801 ctaaagatat gcaatattaa aaaatttgat aaaaataaat caatgggggc gagccgggac 631861 tcgaacccgg gacctcccgc accctaagcg agaatcatac ctctagacca cacgcccggt 631921 agaagttgtt ttaatgaatt tcaaaatatg gtacctcaac atcaatagat catcaaccac 631981 aacgtaaaac atgcatgtga ggcttaggtg atttttgaga taattgttgg gattccattg 632041 ttgaaaaagg ctataatatt aggtatacag aatatactag aagttctcct cgaggatcta 632101 ggaatcctca tattcctctg ttgataatta gaggttaaaa attagtatta atgaagaaat 632161 aagtactgat cttcttatac taaataagag atgtatataa aacacacgct gattggtcat 632221 attaatcatg accaatataa tagtgattcc ggtagttact aaacattgat gtgacgactc 632281 atattcctca tatatgtacc taccataaca tgttcaacta ataggtcttt aacacagctt 632341 cagtattgtc tgagcttctc gtttaacatt ccttctgcaa taggcgcaat cacacttaaa 632401 cgtatacgag gtgtacatta atatacgatg taagcattag attgttacca tagcaactca 632461 tgtcactatt aattactctc gttccaacaa aacaattctt aaaaattcac caatttagct 632521 tcatggcaag gcttacagat gattaaaatc gtgtagatca tggaaatcga acctttcacg 632581 ttctgcagaa tttaaagtga ctccatggcc aagttggtta aggcgtgcga ctgttaatcg 632641 caagatcgtg agttcaaccc tcactggggt cgtttttttt cttatttcag atagtcttgt 632701 cggtagcaaa cagtcaaatc gctatcactt acatgtgata tcatttctgt actgcttatg 632761 cactatgaag tgcggtttct tttttatgcg atattacatg tgtcaatagc aaaaggggta 632821 aaccgtgctc ctatacaaca agaacaatag ttcggaaatg catgagaaca gtgttgtttt 632881 ataaaggatt ctatgtgaaa taaaacaaag gccgatttgt tcgacatttg ctgggctttt 632941 cataaataat ggatcataag aatatataat aggggtaaaa gttattttag cctgcacttt 633001 tgtgttttta gaagaacacc ttatcattgc taggtaatgc gaatggatgg accataatgt 633061 acgagttttg tcttgtggca atacctgcgt aagcgttgta ccaggcaatg aaggctacta 633121 tcacaccaag gaccccacca gctctagtga cgccaacttc gcctgtgaag tttgcaatgg 633181 atagaagtaa gaaggtcact gctaagagga agaataaggc aaaaaacatt atagttgatt 633241 tcatggtgca gacggaaaga ccgaaggtga agagtgccca tcctaggagg taaaacccta 633301 gcgcatttcc aaggtcggat tccttgtcct tataggcatc tagaattcca aaccaaggga 633361 tgtatatagc accgaagctt aaccaaaaac cgccgaagga acacagggct gtaccaccga 633421 aagtgttctc taaagcgatt tcccaaatac cagcaatgag ttgaacgagg ccaccgtaaa 633481 acatggcaca cccaacaaca acattaggga tagtgatgcc ttgggctctt gcattgaaca 633541 tggataggac aaacgtagtg agggcaaaac cggaaagtcc tagtggagca ggatttgcga 633601 atttatggac tggcgcgggg gctaaaccgg gattcagagt accaccgaat gcctcgaaca 633661 aatcatccct taaaaatttt tgacggccga tgtaaatata ctcgttgttt ttgcccgcag 633721 tatatatttt gcatatggac tcttgcgagt ggcggctctg atcgttgttt tcagagatga 633781 actcaccctc ggaagaatcg agtgccttag ggttctcaaa agcggtgttg ccgctgcttt 633841 gttctctgtc agacatgcct tttatttttt tctgtgattg aagattgttt ttgattgatc 633901 tgtagaatgt tacatagtta gttatggcta ttctagctct aggtaggaca gttctcctgc 633961 tttatatatt ttgcttgttc aaagatgatc acggctgttc tcggagtgcg taactgcttg 634021 agagttaaat ccgtcgaagt tgctgatcat ttccagaaat gaggagactg ttgatgatct 634081 actgtgaaat tattgcgggg ctggtagcat ctactgtcac tattattgcc atgtcggctg 634141 gtatcggagt tctccctccg ccgatttagg atggagccgt tccagccgcg tccgctctta 634201 agcgtccgta attggtcaac aaagcatttc agccgtggtg attggaagga aggtcagctt 634261 tcctgtattg cgtctctatc tacttacaat acgaatgata cattgaatta cgtactagtg 634321 tgagataggg gtagtcaaga acttcaaatt gtccattcat cgaaatagac cacttccttg 634381 tcgtgttttg aagccggaaa catcttgaag tagttaaaga tggaaaattc ttcttcatcc 634441 tccaaagcct tattacctgc ctccggctcg ccctcacctt ggttcatttg tagaatgctc 634501 tctaaggtca ctctatagca gtcatgcgtg actttttcca gcttgtcgtc gtacactaag 634561 acttcacaca aagatctgat atttgaaggg gttaactcga cattggccac ttgtgccgct 634621 gtaataaatt ccaaaatttc ttgtgtggta gagtaatttt ttacgtttgg agcataaaag 634681 acgttttttt tgggtccatt ttcgaaattc ttgaagccat tagggaaggt gttctctgat 634741 atgaacctcc aaacaatagt caataaacta ttgataaatt ctatatccag ctctccatct 634801 gtgaaccatg gacctcctgt gatgtccaca gagggttgta agctgtacaa catgtagatt 634861 ttccttgtgg gaaactttac actcttaaca ctcttcacgt atctttggga ttctaaactc 634921 ttcaagcatt taagaactac atgctgatgg agattggttc ttgccttgat agtcttggac 634981 catatccctt ctctaccgct agcctcgata taagaatata ccagtgcctc ttcagccgac 635041 atggtggctt tcttttgcgc ctcagattct aagacacctt gaaattttaa ttcgtcgttt 635101 tgttttacta atttgatcaa gttcttgtct agcaattcct gtacaatgga catcaagtct 635161 gttaacgacc cgattcccat ttgtttttgg agttcttgct gtgtaaataa tgcgcctatt 635221 cctttcgaca tcatctggct atgtaaggtt ttagcattgt ccgatagctg taacccattt 635281 tctatcattc cactcatatt caggatattg gcgctgtaaa ttcttcactt gattaagatt 635341 ttctgtaatg atctcatctc acaaatacat cgcaaatcaa cttgaaaatt tttaatacaa 635401 taaaagattt gaaggaaaaa aaaagtgcct gtgcgcgatg ttacttaaaa acaaaaagat 635461 taaataattg caatatcatc tagttggatt ctaaatatac taccaaacaa gggcttaaac 635521 attttaataa acgatttaca tatttactgt gggtatggca atgggtgagc gtaggtatgc 635581 tacggtaggc gatgtagtga gtagtgcgga cgaaccgtag ccgtaacgtt taatgccccc 635641 tgccttttct tctcaattgc tcacatgtaa gcaaagtctt ccaagaatct ggttttactc 635701 gtagcctttt aacgctgttt tttttttttg cacaccttta aaacctatag aaactccttc 635761 atataaaatg tactagttat aagatgactt tttatattca aaattagaag aaaacttaac 635821 taaaattaaa aaaatagcgg ctattaaaag gtattaaaaa gtgagaaaaa aagaaaaaaa 635881 ttataaactt gagaaatcaa aggagactaa atgcataagc aaagagaaga ggatctcctc 635941 ggatgataga tttatacaat tactctaact tagaaggttt actagacgga ttaacggact 636001 tgaatcgaat tccgaaggaa tactccgcag tattggagcc atattttcag aatatagcaa 636061 gaaatgcaca tttaaagtct agagctctaa aaatttgtcg ttctaatttc cataaatgga 636121 acgaagaagg tgcgaagaca gtcaatccgg aaattataag aagatgcctt aacctgtggt 636181 atgttttgaa gggcaaggaa tataaaaagt tgaaggatcc tccgcctgct gataatatca 636241 ttaaggatga gattgatgtc tcatatgtta agaatttgaa tgtagtcagg ttggaatttg 636301 acgaatttgg taaactcata agtaatccat tagagaattt gatcttggaa gaggtcgaag 636361 tgaatgattt catacaagaa taaacctaaa gtgtgttcac tcatctaata tgcacggagc 636421 ctacctttta gcttttgctg ccaaactaaa ccaagattga aagatatata atcgactatc 636481 tttcgtctcg taatctgtat catgcaattt aaattaatta tcaacataaa atgctctagt 636541 tagcacgcgc atatccagga aagttcacca gtaactatgt actagacaaa agcaaactgt 636601 tcggagcgac catacaccat atgttgttga atcaactttt cttaaggctc tttcgagttc 636661 atcattaacc aacctaggta ttttcccgat tttttggtaa tatgtcaaaa cagctacttt 636721 gtatacattt atagacgcct ggtgtccttt gagcctcact tatataaagt aaccttcaca 636781 agattttgga ttttggtaat acatacgcta ctgctatttc ttgcggagca gcagaatcat 636841 cttgctcggc ctccttttct gaaaatttcg atgatacctg aaataatcat cattagcaga 636901 gggaatttaa aaatagaggg tgtaaaatta tcaagatttt tttttgctaa ggtgaatgag 636961 tagtgagtaa agaactaaga acagtatgtc cgttagcacg ccaagtgagt tagacgcatt 637021 aatagaacaa gccactagtg agagcattcc caacggtgac cttgatctcc ccatagcgtt 637081 ggaaatttca gatgtgttaa gatctagaag ggtaaatccc aaagattcta tgcgttgtat 637141 aaagaaaagg attctcaata cggccgataa tccaaatacc caattgtctt cctggaagct 637201 taccaatata tgtgtaaaaa atggtggaac gccttttatt aaggaaattt gttccagaga 637261 gttcatggat accatggaac atgtcatttt aagagaagat agcaacgaag aactttctga 637321 gctggtaaag accatattat atgaactata cgtagccttc aaaaatgatt cgcaacttaa 637381 ctatgtggca aaagtttatg ataaattaat ctctcgtggc attaaattcc ctgaaaagct 637441 aacactttcc aattctccga ctgcaatgtt tgactcgaag acgcccgcag attggattga 637501 ttctgatgct tgtatgattt gctccaaaaa gttttctcta ctaaatagga aacatcactg 637561 tcgttcctgt ggtggagttt tctgccaaga acactcatca aatagtatac ccttacctga 637621 tttgggtata tatgagccag tcagagtatg tgatagctgc tttgaagatt acgatttgaa 637681 gagacatgac gacagtaaaa aatctaaaaa acatcgccat aaaagaaaga aggacaggga 637741 ctactcaact cctgaggatg aagaagagct gataaggaaa gcaatagaac tctccttgaa 637801 agaatctaga aatagcgcta gtagcgagcc tattgtcccc gttgtagaat caaagaatga 637861 ggtgaagaga caagaaatag aagaagaaga agatcctgat ttaaaagctg ctattcagga 637921 aagcttgaga gaagctgaag aagcgaagct acgcagtgag cgtcaaaaag cctctagaca 637981 gatgcaaccc caacagccat cacctcaacc tcaacctatc cattccgttg atttatctga 638041 tgaggagaaa gacagcatat acatgtttgc ttcacttgtc gaaaaaatga aatcgaggcc 638101 cttgaacgaa attttggaag actctaaatt acaaaacttg gctcaaagag tatttgcttc 638161 caaagcaagg ttgaattatg ctttaaatga taaagctcag aaatacaata ctttgataga 638221 aatgaacggc aagatttcgg aaattatgaa catatacgat agattattgg agcaacagct 638281 acaaagcatc aatttgtctc agcaatacac acttccacaa gtcccttctg atccgtacaa 638341 ttacctaaca gaaaatgtgc aaaatccagc agaaagctat caaacacctc ccctccagca 638401 actatcatct catcaataca aaccacaaca ggatgtctca cgccaacaat cggtaaaagc 638461 aaattcatca cctaccacta atattgatca cttgaaaacc atcgatgtga caccacacgc 638521 acagcaaaag cctcaatcgc acgttgaact tgcaccttcg gacccacctt atccaaaaga 638581 agaggccgaa gatgaaggaa cacaggcagt gcaagatgag gaatcctcca cacaagaatc 638641 ccgcgaaagg ccgtatccag tagaaacaga gaatggtgaa acttcaataa ataaacggcc 638701 tcaaggcatt acacgttacg attttccaac tgttcctgca cgcaaattcg tccaaccgga 638761 gtcaactgta ccacttcctg caagttcctc tgaaattccg atcaaagagg aaaggccgcc 638821 tagtcctcaa gaggaactgc taatagagct ttaatattgt agccttttct atgtatttgt 638881 aaaaagaaac ctagcgctta taaatatata catacatata tatataattg cttgttacgc 638941 aacttataca tatttctgtc attaaactag tttttaaggt gaatattcat aatttatgtc 639001 agtattaaca ttgaaaccgt caaaaaaaaa agtatcaata tagacaaagg aaggaccatt 639061 ttaagaaagt ggttttaagg aagaaacttg ttcctgcata tttatagtta attcctatct 639121 tcttgtttat cctgtttttt gaccacctgg cttgcagcta atagtgaaaa aacacaaatt 639181 tttaccaacc ttccatggta tagtcatgtt gtatactcgg tgtaacacta gtaataaact 639241 ttaagaaaac aatcaagtat tggtctaccc gtaacgaatc atcaatatcg tcttgtaaat 639301 cctcccagtc tccgacaccg tccagctctt gttcttcctg cagctctttc cttcttcgtt 639361 gtctaaccac acgaacctta tctagcaata ttttcattac attagcatgc ttacatggat 639421 gaatggaaac agataacact gaattcttgt aaaaaggtag cttttcaatg gtggctgtct 639481 ttgttctata atctgctgat atatcttcga acatctgctc agggcttagt ggtgaaccat 639541 tagaattaaa ccccactata tacattttag ggaccctata agatgtcgag tacgcaatat 639601 aaaggtcgta atacctttct tgcgccatat ctttggctag gccaccttta gcattaaatt 639661 cttctgtatc gtcattttca tcctcctctt ttatttccat gtcttgtatt agctcatcaa 639721 tatcatcgat agatgagtcc ttggtccccc ccgcaggcgt actttgcaca tgttcagttt 639781 cagatcctat gtattccaga acatcatctt catctccatc ttctgcaaaa cctttcatga 639841 ttacatctgg cccttcaact tcgacacatt gctcggcacg tttatcacag ggaacttttc 639901 taattatcag aaactgctta ttcttcggta aaaaatctct gtaactaata tctgacgact 639961 cttcgttcca cttccaggtg ggaaacatat gacataaata atcacctgct tgtacaaact 640021 cctcaggagt tatttgacct gtggttaaaa aggtagattt gtgcgttatg ggggtaagat 640081 attctctcca actacttagt gtagatctaa tcatgataat aaaattgtat ttactccttt 640141 gtacttcttt gttcctaact tctagctagc ttgatatacg tcaagtgtac gtaatcattc 640201 aagtatctac tttcctttaa atagcccttc gctctgcttc ccttataata ataatgtccg 640261 tgtacaaaat tgaatgccca agaaggtgaa atttgaaaaa taagaaatct actaaatacc 640321 gatacgaaga agcgtatagt aacagccatt acaaaaggtt ctctaccaac gaattcggcg 640381 acaatcgagt aaaaaatggg cacactgttt cgaagaaatg tccagaacca aaagagtgat 640441 tctgatgaaa acaataaagg gggttctgtt cataacaagc gagagagcag aaaccacatt 640501 catcatcaac agggattagg ccataagaga agaaggggta ttagtggcag tgcaaaaaga 640561 aatgagcgtg gcaaagattt cgacaggaaa agagacggga acggtagaaa acgttggaga 640621 gattccagaa gactgatttt cattcttggt gcattcttag gtgtactttt gccgtttagc 640681 tttggcgctt atcatgttca taatagcgat agcgacttgt ttgacaactt tgtaaatttt 640741 gattcactta aagtgtattt ggatgattgg aaagatgttc tcccacaagg tataagttcg 640801 tttattgatg atattcaggc tggtaactac tccacatctt ctttagatga tctcagtgaa 640861 aattttgccg ttggtaaaca actcttacgt gattataata tcgaggccaa acatcctgtt 640921 gtaatggttc ctggtgtcat ttctacggga attgaaagct ggggagttat tggagacgat 640981 gagtgcgata gttctgcgca ttttcgtaaa cggctgtggg gaagttttta catgctgaga 641041 acaatggtta tggataaagt ttgttggttg aaacatgtaa tgttagatcc tgaaacaggt 641101 ctggacccac cgaactttac gctacgtgca gcacagggct tcgaatcaac tgattatttc 641161 atcgcagggt attggatttg gaacaaagtt ttccaaaatc tgggagtaat tggctatgaa 641221 cccaataaaa tgacgagtgc tgcgtatgat tggaggcttg catatttaga tctagaaaga 641281 cgcgataggt actttacgaa gctaaaggaa caaatcgaac tgtttcatca attgagtggt 641341 gaaaaagttt gtttaattgg acattctatg ggttctcaga ttatctttta ctttatgaaa 641401 tgggtcgagg ctgaaggccc tctttacggt aatggtggtc gtggctgggt taacgaacac 641461 atagattcat tcattaatgc agcagggacg cttctgggcg ctccaaaggc agttccagct 641521 ctaattagtg gtgaaatgaa agataccatt caattaaata cgttagccat gtatggtttg 641581 gaaaagttct tctcaagaat tgagagagta aaaatgttac aaacgtgggg tggtatacca 641641 tcaatgctac caaagggaga agaggtcatt tggggggata tgaagtcatc ttcagaggat 641701 gcattgaata acaacactga cacatacggc aatttcattc gatttgaaag gaatacgagc 641761 gatgctttca acaaaaattt gacaatgaaa gacgccatta acatgacatt atcgatatca 641821 cctgaatggc tccaaagaag agtacatgag cagtactcgt tcggctattc caagaatgaa 641881 gaagagttaa gaaaaaatga gctacaccac aagcactggt cgaatccaat ggaagtacca 641941 cttccagaag ctccccacat gaaaatctat tgtatatacg gggtgaacaa cccaactgaa 642001 agggcatatg tatataagga agaggatgac tcctctgctc tgaatttgac catcgactac 642061 gaaagcaagc aacctgtatt cctcaccgag ggggacggaa ccgttccgct cgtggcgcat 642121 tcaatgtgtc acaaatgggc ccagggtgct tcaccgtaca accctgccgg aattaacgtt 642181 actattgtgg aaatgaaaca ccagccagat cgatttgata tacgtggtgg agcaaaaagc 642241 gccgaacacg tagacatcct cggcagcgcg gagttgaacg attacatctt gaaaattgca 642301 agcggtaatg gcgatctcgt cgagccacgc caattgtcta atttgagcca gtgggtttct 642361 cagatgccct tcccaatgta aatgaccgac attgactcac tatccatccg tgtattattt 642421 caaagagcga aaagaaggcg cgtcgcgtcg acgcgccttt ttaggctaga aaataaacag 642481 aaaacaaaaa caaaaacaaa aaaaggcgaa aaaacaaacg aaaaaacaaa cgacagtaga 642541 tagaggagaa ggtttttgac aggtttgtgt aattggttat ttgcttttat agattatata 642601 tacacaaact taaaacactg ttttctaagt aggctgcgga gagggccaat tgcagcagcg 642661 acgtacgcat agaggaaaaa caaccgttca tgtccattat gaagcagagg ctaccactgg 642721 gggagttttc cagctcgaag atcaacaaac tggcaattgc caatattgca gacgctagcg 642781 agcctagaaa ccatggagaa aacaacgtcg ggactgtgtg tcttccctct atcaagagtt 642841 tgatggttag tcctgaagta tacgaaaaca cgaagagtct tcctgttccc ctaatgagga 642901 gcagtggcgg aggtatggct tgtgccagta agtcctcatg ccaggatggt attagtacga 642961 aaacaacgtc tagagattac tctgagcttt ccaagaagtt gcaaattcgt ttacagttcg 643021 cctattataa atacaagact aagcaaacag acaaaaattt cacagacttg aaatcaaagc 643081 atagcattac gaggccttcc aaagtcgcga ctcacagtaa atcagaacct ttaactagga 643141 gaagaaaatt agtactatct cagggtcatt ataaaacccc tgctaggtct aagatcaaaa 643201 ctccatcttc gatttgctct cacgataata catcttcctt tacatctttc cgcggtgtca 643261 gcgaaagctc gagcactacc gcagatatga acgtcgcaga taccaccaca ccaatacgca 643321 acaacataaa cacaaagcat tcaaacagtc ataatcgcac attgtatcag agacaagaaa 643381 cacctacaag catcaaagcc gctaagtctt taattcatct ctttacaagt aaccaataat 643441 cccaccccca atatttctat ctttcatttt cattctcctt cattgtgtat ataataatat 643501 tattgtcttc gtatatcttc cacattacct tttcacttcc gctttagttc tgtacgtata 643561 attagataga atatcatata aaacctgatt ttattagtat cgattgcaat tctactgcgg 643621 ccattaactg taaccgaatt gaagaaaata aaagaaaaaa agagaacatg cataaatggg 643681 aaaaagaagg cgaagcatac cagcatctac cagagagaca cgagcactga aagtcgccat 643741 aaaatgaatc tacagaacaa cgttttaaat cagatacacc agattctgct gcctacgaat 643801 cctactctcg ataaacctaa tgctgaggct acaaaggaag aattttcgtc tgcagaaaat 643861 agagatgaaa aagactatct taccaaccag cagccgaaaa atctgagtac tccctccacc 643921 agttccaacg gtgaatttat accgcatatt ttttattcgc tgcaccaaat aaggaaggat 643981 ccaaacaatc tctcaaatca attggaaacc ttaacaggtt cgattagaca tcgtttgaaa 644041 ctttgtaaat ctttgatatc ggaaaacgaa gataccaagg atttattaag taaaagtcca 644101 tcagaatggc aggatatcat ccatcaacgt gaacaagaac tgcaaattaa gagagacgtc 644161 ttggatgatc tttatcgcaa gttacaacga taaaatctat gctatctatc tttagtctat 644221 atatatatat atatatacat acgcatacca catcttcaaa cgtgcatata gaatggagcc 644281 tgcgtttcta gcaatacaca tacacctgtc aaaaaacctt caccgcctcc ccctatttgt 644341 tttatcgtca attaaatctt taaagatttg tggaaccatg tctatcaacc attcttcctt 644401 agggataact agacagtccc tgataaattc cttcgacgtt agcatcaatt gttgataaag 644461 cacatatttg cttggtctct gcgccttttc cttatgatta acgaaaagta tactggtagg 644521 atgaacacta acgttcagcc cacctgatga cctacccatg gtttgatagc cggtggggcc 644581 taattgtaca atattcatcg gaaacccgct gatgaagcat cgagttattc tagcatttat 644641 gtagcccgct atattgccta tcttcatcct ggcttggtcg ttcttttcaa ctaatccaac 644701 cttttcactg cacctgaata attggtttct aatatttctt accctcaaca tcgttttgaa 644761 ttgaattttg tggtcttgac accaacttct ggaaaattta gagtttctcc attggttgaa 644821 gatttccaaa tacaatatgt gatcactttc cacttcgctt aacacacttg ccgcagcatc 644881 tcttttttga ccaataaata atgaaggtgt ttcatgtagc atcgaaacta tggtcaaaca 644941 ctcttctagt acaccttgac attgttcgtg cgtagcagct gtataaagca cttttgcaaa 645001 ttcaggttca caaggaaact cgcacatcat tttacctaac cgagtgattg tccctttgct 645061 atttaaggca cctaaaatgt ataaattttc caaagacttc cgtaatgtgg ggatactggg 645121 cttatccatc aggggaaact ttattaggtc agtaacgcca agcgataata ataataacac 645181 cgtattagaa agatttgttc ttgtgatctc aggcttaggc ataagttcca actcgtgcaa 645241 atatgaccat ttggtaaaaa ttctaaaaca ttttcccggc ccaacacgac cagccctacc 645301 ggcacgctga tcaactgaag ctcttgagca tggaactgtt aaaagttggg tcattccagt 645361 ggagggtacg tacgaatttt ccttaacaaa tccaggatca atgacatatc taataccatc 645421 aatggtcaat gaagtttccg caatattagt tgccaaaaca actttcctac aattttccgg 645481 agtcggctgg aaaattttca attgctgctc ttggggtaaa tttgcgtata taggagttat 645541 aatcatttgt tttgttctag aacctaattt agacatgatc tcctccagtt tggtttttgt 645601 tctttcaatt tcttcttgcc ccgttaaaaa caccaatata tcccccggta aactttgcgt 645661 agtatgaatt tgaaaaatag ttgttatagc ggcatgtata tagtttgcct ccggctgtaa 645721 tgtgtagtgg atatctacag gatatcttct cccaggaacg ttgaaaatgg gacaattatc 645781 aaaaaactct gaaaattttt ttgcgttcat tgttgctgat gatataagca attttaaagt 645841 gggcctctgc ggcaaaatat ctttcagcaa acctatcagg atatctgtgg ctagagtacg 645901 ttcatgagct tcatcaatca taatacaaga atatttgctt aatttggaat ctgtaagaaa 645961 ttctcttagt aacataccat ccgtcatata ctttagaacc gttttatttg gggttgtttt 646021 gtcttcaaaa cggatctgat aacccacttc cttcccaagc acaacattca tttcatctgc 646081 tactcttgca gcaacagaag tggccgccac acgacgtggt tgtgttatgg caatctgtaa 646141 ctttccctga tcagtgaatc catcttctac caaatattgg ggtaactgtg tggttttacc 646201 agaaccggtt tcacccatta taatcaaaac ttgatttttt ttgatctctt gtagtagctc 646261 atccttgtat tgatgtacag gcaaaagttt tcttgcctct tgtatagtca gtatacgctt 646321 ttcctcagtt tctaaagctt gtgctagacg tgcctcatat tgaagtttct cttcaggtag 646381 taaatcgtcc tcctcattag tataatcaat cattgcatct gtgtcgaaca cataatcgta 646441 cttgtcagag ccttccaatg ttatatcatc agggtgatcg ctttgccccg ccatagcatt 646501 tcgcaattgt tgttcttccc acatgcgttg tctgtttatt ttgtcaattt cttttgcatt 646561 ctttatttta tgagtaactt ctacgttaaa tttagaatta gaagaggcgt acttagtttc 646621 attctcggag tcacctagta gacccttctt tgtagtaagt tcattatttg acgttatttt 646681 ttcatcatac tttgatgact ttttttgtga tccaagttgt tctcctttta aattgttctt 646741 ttctggacct tggttcgtat tagaaaaaac tttattgggg tcatagcgtg atcgttttag 646801 ctgcaaggca gagttcttat ccttggcctc tttgtcttct tcctcaccca aggaagaagg 646861 ctctattctt actgcattgt cattctgtct tgtaacttca tacgttcgtt tcactcttcg 646921 cttaccggtt tcagatgtaa tacttgacat gtgttgctat acacgcttgt tatctatata 646981 gatgccaatt aaacatatag cagctatccg ttattactta tacaattgat taatatcact 647041 ttttaattgt ccgggtaact aactgtcttc cactttcagc acgttctcgt catcaggttg 647101 tatgggctag tactgttttg gctacatttg agatacgagc acttaaagaa ttcttgcata 647161 ttttcgatga ttagtcttta attttcccac ttgttctcac tatttcctct attgtcttaa 647221 tacgctcaca tatcgaagtt tttttttcat gcgatgagct tcgagatgaa aaaaggaaac 647281 tgaaaaattt agatcgataa gataagagat gtgatttttt ttttttttcg taaggctgta 647341 ggccttggat aacgtcttat ttactattta tatgcgacat cttcgataat ttcatacgtt 647401 taatttcgaa ctcgcattta ttttatttat tatgtcccat cgtatagcac cttccaaaga 647461 acgatcttca tcatttattt caattttaga cgatgaaaca agagacacat tgaaagctaa 647521 tgcagtcatg gatggtgaag tagatgtcaa aaaaacaaaa ggaaaaagct ctcggtatat 647581 cccaccatgg acaactccat atataatagg tataggtggt gcttcaggtt caggcaagac 647641 aagcgttgct gctaagattg tgtcgtcaat taatgttccc tggacagtat taatatcttt 647701 ggataacttt tacaatccat taggcccaga ggacagagcc agagccttta aaaatgaata 647761 cgatttcgac gagccaaatg ccatcaactt agatttggca tataagtgca ttttgaactt 647821 aaaggagggc aaaaggacaa atatcccagt ttatagcttc gtccaccaca atagagttcc 647881 tgataaaaat atagtcatat acggggccag tgtggtagtt atcgaaggga tctacgccct 647941 ttacgatcgc cgattgctgg atttgatgga cttgaaaatt tatgttgacg ctgatttgga 648001 tgtctgctta gcaagaagat tgtcgagaga tatagtttcc agagggagag atttggatgg 648061 ttgtattcaa caatgggaga aatttgtgaa accaaatgcg gtaaagtttg tgaaaccaac 648121 aatgaagaat gcagatgcta tcattccatc gatgagtgat aatgctacag cggtaaattt 648181 aatcattaac cacatcaagt caaaactgga actaaaatca aatgaacact taagagagct 648241 aatcaaattg ggctcttctc cttcacaaga tgtgcttaat cgtaacataa ttcatgaatt 648301 gccgcccacc aaccaagttc tttcgctgca tactatgctt ctaaataaaa atctaaattg 648361 cgcggacttt gttttctact ttgacaggtt agcaacaatt ttgttatcat gggcacttga 648421 tgacattcct gtagcacata cgaacataat tacacctggt gagcatacca tggaaaacgt 648481 tattgcctgt caattcgatc aagttacagc tgttaatatt attcgatctg gcgattgttt 648541 tatgaagtct ttgagaaaga cgatccccaa tatcacaatt ggtaaattgt tgattcagtc 648601 cgattcacaa actggggaac ctcaactgca ttgcgaattt ttacccccaa atatagaaaa 648661 gtttggcaag gttttcttaa tggaaggtca aatcataagt ggtgcggcca tgatcatggc 648721 catccaggtg cttttagatc atggtattga tttggaaaag attagcgtgg tggtttattt 648781 ggccactgaa gttggtatcc gacgtatatt aaatgcattt gataacaaag tcaacatttt 648841 tgctggtatg atcatctcca gagaaaagtt acaaaatcat caatacaaat gggcattgac 648901 cagatttttt gattcaaagt attttggttg tgattgagaa taattagagg caatataaag 648961 taaaattaaa taatagtgca cgtatacata ctatattagt aacctttcat tctctctatg 649021 gataatctta aaatcccatt actttcaata tgccataacc tactgtaaca atagcggcat 649081 aacttaacaa actggctggt acacctctcg taataaatgt acccacggtc aaatatctat 649141 caccaacttc atcaatcatt gaaatggcag tcacgttggg gaaaccagag gttggaagac 649201 ccatagcact agagcataat agggcggcta taacgatcaa tagtctagaa tgatcacctg 649261 aaggtagatt ggaaccgatc tcactcatta atggtacgat gatcattgcc gcgacggtat 649321 gggagacaaa agtggccatt acaagaatca ctagaccgaa gatcaacaca ataatgaaga 649381 ttggttcatg ctcaacctgc gccttaatta actgtgccat tgtagacaat aaaccggatg 649441 agcttaccgc cttacctagg gtggtacctc ccatggccaa aacaacgatt gtccacatga 649501 aattattgaa atcatccgaa gttagaagac ctgtaccgaa gaagactact ataggtataa 649561 tagatatgat tcccatttca ccaaagatac cggagatttg gtttgaaaga caccaaagaa 649621 caattgttat aatgcaaact aaagtgacaa accattgctt cagagtgaat ggatcacggg 649681 atggatgcaa ttgcaaaatt ttcacatttg gctcaggagg gaaggttatg atcaatagca 649741 cccaaattgc catgacacaa ataaagcaca caggtagcgc aatcataaac cattcagccc 649801 aagatggtga agggtccatt ataccaatag aaaaaatgtt ttgaggagaa gcgatgggag 649861 aagacatacc accgatattg gaggcaagag cgataccaag aattagagct ttggcatagg 649921 aacaatttct tggcagtgtt ctgagcaaag gttgaacaat tgaatagcaa agaacggggg 649981 cagcaacatt agaaacccac atggaaacaa agagcgccac aaacatattt gttaaaagaa 650041 taaaatgtgg gtttgtaccg gcggatgcca aaatatgcgt agaaaggact ttggcaatgt 650101 tgtacttgga aagggcggct gctaaagtaa acccacccag caaaagcatg atgacactcg 650161 accacatcgt tgataagatg aactgagagg aatcacgggg agacattggt tgggaggtga 650221 tagggtcctt gataacaggg aacactacaa taagcagagg aatcattaga gaagtcacga 650281 aaagggggat ggtctcagtg gcccataata aagatgcata tattaagatg gcgaaacagt 650341 ttttctgtaa ggaatcctgc gtaaaaggag tcaaattaaa agttaataat gcaatgaaac 650401 atgaggtgat taacagaaac ttcagcaggg aagtttggcc catgataaat tgcaaccatt 650461 gcttgggtgg taaatgcatg agttcacgga aagttaggga atccgttgat ggagcgatga 650521 taccggcgcc accactcgac attgccatgg attcagtaat gttggcattg gggcgcaatt 650581 gactggaact caactttgaa aacttcttgt tgtcagtctt ggcagattgg tactttctct 650641 ccaaattcat catatctttc caaacggtgt ttctttccca aactacgtga tctctcaaat 650701 gagaggataa ttcacgctca gcatcctgga aatcgaggac ttcttgtctg ttgccatctt 650761 cgtcttcttc attaccgctg ctgttttcgt cattgttgat tcggtcagcg tccaagttaa 650821 acgtattaga tggtcgacgc gtgcccttgt tcaagctagc gtaagtgagg atggtctcgg 650881 taatgtgatg ctgaatccta tttattgtag caggattgaa aacatgcgaa tggaatttga 650941 tatagttcaa gtagttctgc ttcaagttcg tatttaagga cttgtcaaat ttcttgcaga 651001 tcttggagaa cccggtctgg ttcaactcaa taaagtcctt caactcggac aactgggtgt 651061 agatcgatat caatcttttc tttaaagaga gcctatgttg ggtaaaagga gaaagataca 651121 cagggttaga gttagaaagc gacactgaag cggaggccag gttttgcatt gagttaccat 651181 tattagtcgt gttcgagacc tgcgtgtgga tgacgggtgc agagtcaatc gacatgtctg 651241 tcagagaggg gttggagtcc gtggaggaga cactactaaa ccttctttgg cgttgttgtg 651301 acttagactt cctgtttctt gcaacacttt gcagttgatg ctgttgctgc tgattaaaca 651361 attgggtggc cttgttcgtg ttttccagtt ccatgacatc gtccttcaat tcgttgtagt 651421 tggcgataag acctgtttct tgagatatgt agaatttatc aatttttttc aattcttggt 651481 ttaaggcagc aacaaattta gagatgtaga attgatcatc tggagaagca tctgccaata 651541 gcggcagatt ttcatcgttg gcgtcatgtg gctccacaac atggtgctta ttgttactgt 651601 acagcttatc tttttgcaaa gaatagatca attttttcag ctgcgaatag gccagatact 651661 tggtagacca ttctggtaca gaattgaatt gtaaggaatg cgagaacttc atgtcagtct 651721 gcaagttacc gtgtcacctt cacagttttc tttttatttg actaagtaaa aaaagaaaag 651781 aagttatttt tactaagatt ttgagcggca tttttcctag ttacttatca attttcatac 651841 atgcaagaca tactcaattt tttttttttt ttttcagttt taaaattagt cctgatcaaa 651901 aagccatcac gtggatcccc gaaaaaaaac ggatccgggt aaccagaagt atttttttca 651961 agggaataaa agttacccta ccaaaataaa aaaattcaag tagggtaata aagttccacc 652021 ccccatcagg attatcgttc tctgacatca cccactctct gctcgctctc tgctcgctct 652081 ctgctttctt tccccacgcc ggagtgatta aggcggatag gcccacctga acacctcgct 652141 cagaacatca gcgagagttc cagcccctct accccttacc tctcgccgcc cctcatttcg 652201 gatcaaaagc aaaagaacaa agggccttcg cagaaacgga aggtttcgac ccctcggtgc 652261 cgttttaatt tctttttctg gccagttaag ctttttgact ttctcgaatc agcccagtgc 652321 aaaacagtac gcatacgagc acacaaatgt atatatatgt gtatgtatat atgtatatag 652381 gtatgtgtgt gtacatccga agcgtaaact aatgatctgc aagtttcaga ttttttctcg 652441 aaaaatataa ctaataaacg ttccatgtcg tccacggata tcaagccttg tgccgtgaac 652501 atccctgttt ccgctcacat caccttccac tacaagtcga tcgcggacag aagcagcagc 652561 aggagcagca gcagcagctc ctgctcctct gctacatcta aagcctgctc ccccagaggc 652621 agctccgtcg gcttaccgcc tgctttatca actgacaatg aaatcgtcga gactgtactt 652681 aatgtttccg ctcccgttgt agcagaccct acgcggccct cattgttcaa gagtaactac 652741 accgcagcct cgtgcttgac ttctgaccca acctcgccgt cactactgcc ctcttctagg 652801 cgcaactctg tattgccggc aagcgacttc caccaatgcg cgcatcacaa aaactttcaa 652861 agaagggcca gtgagccaca actgccctcc ttcgataatc gctcgtcgtc cgagatgaaa 652921 aggtccgtct cgtacgccca gcatagcatg atgttcccca tcagtgacca acaggagccg 652981 caaacatccg cgtctcctaa cgaccactca gacccgtctt gtccttgcaa cagacatcac 653041 cacagaagaa actcggtcgc cgtcaagttt gacaaaccat tgtatgagag actagagacg 653101 tagttatcca ttcgtccatc catctgtcta tcgtcacaca gcatttccca tccctcctct 653161 atacatacat acatatacag ttctgcgtgg tctacgcagc catgtatata tatatttccg 653221 tcgttttata tattcattac taaaatcgac aatgcatttt ttgccgcttt ccatttcctc 653281 tactttgctc atcacttcgc tcgaagaaaa aatgaaaacc gtcttgaaaa acttttgcta 653341 tttcatccat ccaagccaca ccaaatagcg cagtcacaca gagatcatgg ttacatatgc 653401 tggaaaactg gttctagctc caatggtaag agccggcgaa ctgcccacga gactgatggc 653461 gctggcccac ggtgcagatc tcgtctggtc cccagaaatc atcgacaaaa agctaattca 653521 gtgcgtcagg aaggaaaaca ctgcactcca aactgtcgac tacgtcgtgc cgtccaaggt 653581 tcaaacgagg ccggagacgc tcgttttcag aacatatcca aaactagaat cctctaaatt 653641 gattttccag atcgggtctg catccccggc tctggccacc caggctgctt tgaaagtgat 653701 caacgacgtc agcgggatag atatcaatgc aggctgcccc aaacacttct ctatacactc 653761 cggcatgggc tctgccctct tgcgcacccc agacacactg tgtctcatct tgaaagaact 653821 ggttaagaac gtgggtaacc ctcacagcaa acccatcagt gtgaaaataa gactcttgga 653881 caccaagcaa gacactctac agctcgtcaa acgtctgtgt gccacgggca tcacaaatct 653941 tacagttcac tgcaggaaga ctgaaatgag aaacagagag cagcccatca cagattacat 654001 tgcggagatc tacgagatat gccaggcaaa taacgtgtcg ttgattgtga acggcgctat 654061 ccgcgaccgc tctcattttc atgatttaca agcgaatcat tggaaaaaca ctaacattgg 654121 tggtatgatt gcagagtgtg ctgaacggga ccctacagtt tttgatcaca cttctaagcc 654181 ttcagaagac ggtccatctt gggtcgttgc ttgtcgcgag tttattcagt gggcaacgaa 654241 gtttgacaac cacatcggca atacaaaata catgttaagc agaattgtcc ccggaaaatc 654301 agtctttttt cagtactttg cccgttgcaa gagcccggaa gaagttagtt tcgtactaaa 654361 gcaattgaac gatgatggaa gcgctcaaac agatccttca gagtacttgg aaaactgcag 654421 agctcaagaa aaagctttga aaaacgccaa cgccatcgcc aagcaaaaga ggaaacagac 654481 cgatcacata ggcagtgaca ctaaaaagca aaaggttgta ccccttccca cagatatata 654541 atatattcta agtaaaaaga acggattatg aaagaaaacg cgcataatat atatatgtat 654601 gtattttcta atttatatta gcaactaaat taaattacat caatactatt tttttttttt 654661 actttacaag gtttatttca aagtcttcaa caatttttct ttatcatcgg tagataacat 654721 cttgataact tcagataatc catcaatagc attgtcatgg tcgcttctga tctttttagc 654781 taagtcttga gcgaatgact ctaatttcaa accctttagt ttatcgtcca aagttttgta 654841 gttttcttca atccatgttg cgacttgcct atcatcttca tggtccactg aagcagggta 654901 ccacgatcta attcttgcga tcttttctaa tcttgatgct tcgcctacct gatggctcaa 654961 ccttttaatc aaatattctt cgttcaatct tcttctcaat ctccagaaga agaaacgacg 655021 tgcctcggtc cattccagtt ccttagaaat aacacccttg gccaccatac gtgaagacct 655081 atcgtgcaaa tcagcaaatt gaagactgat ttgtccgtaa attggcaata gttctctctc 655141 acgatcagct aattgcttgg atatttgctg atgtacttct ggagccaaac tcttgttgga 655201 taattgagat ctcaattctc tgtacttgtc atccaatctg ttcatggtgt ccagcaattt 655261 ttctctacgg aacttgatac caaccatacc ttgtggttcc aaaacaccag ctctagcgtt 655321 gacgtcggca tacatttcca tttggtcagc gttgatagtt ggatcgacaa caacccatga 655381 accacctctt agttcaccgg taggtgggat atagataata attggttgtt tgtaatccac 655441 caatgcgtca acaataaacg aaccatactt caagacttcg ttgaacatat cacgttgacc 655501 accagagaaa cctctccagt tggccaaaat catcattggc aattgttcac cgttgttaaa 655561 gtcattgata gcttgagcag tcttgaaggc ggagtttgga tgccaaactt gaccaggttc 655621 ttgaattaat gtttcagcac tatttggatt agctggatca gcaggaatca agttctcgac 655681 agttcttgtt tcaacaccaa taacacccag tggaatacca ccaagacggg ctctaccaac 655741 gacaacacct ttggcccatc ctgacaaagt ttcaaagaaa gaccctttat caaacaaacc 655801 atattcaaat ccactttcag tctcacgacc ttcaatcatc catcttacat cgtaagtttc 655861 atcattagtt ggagtgaaat caactggtct atcccatgtg tctttagttt ccaagatagg 655921 aactggcata ttacgcttgg ctggaacata agacatccat tcaacaatct tctctacacc 655981 agctaaatcg tcaacagcag tcaaatgtga aacaccgttg ttatacatga tttgagtacc 656041 acccaattgt aagttagaag tataaacttc tctacccagc attttgttga ttgcaggagc 656101 accagttaaa ataattggct ggccttcgac ctgaatagct ctttgaccca aacgaaccaa 656161 ataagcaccg ataccgacgg atctacaagt gactaaggtg atagtgaaga tatcgtggta 656221 agcccttgac gttgcaccag caattaaacc agatccacgt agacattcga cacctaaccc 656281 atcttcagaa ccaataattg tcttgatgac aaatctttct tcaccgttta taacagtacg 656341 ttcagtgaga acagaatttt ctttgtcaaa tttctttaaa gtttccatac cttcacttgt 656401 taagtataag tattggaagc ccttgtccgg attggcagca tcattccatg caacttgaaa 656461 tagtggaaca atctcttcag ccataccaat tctggcacct gagtttgcag ccaagtaaat 656521 tcttgggata ccacgctttc tagcatattc agtaacctta ttgaagaatt cgtcttcttg 656581 tggaccaaag gaaccgatct tgaatgtgat atcgttagca acaacaacaa attgacggcc 656641 tcttggatat tcaggagtct ttacagtaat cttaaaggca accataccaa tagcgttggc 656701 accaggttct ctttccacct cagttaattc gccgttttca tcttcaatca actcgttgga 656761 aataaagaaa tcatctgtta acttaacatc tgcagagaaa tttttccatt gggatgacga 656821 tgcttggcgg aataattctg ggaagtcata gacatatgtg gtacccatca agtgtgcctt 656881 ataacgtttt ggttgcaacc attccttaac agggtaagga gtagcaatag gtcttaaatg 656941 catggatcca ggtttaccca aagacttaaa tacccattca ccttttgcgt tcttgacttc 657001 ggtgtacatt tctgttttga taacataacc agaaacgtta ttgatcaagg cacgcaatgg 657061 tactggggca cctgtttgag gatctttgat gatgattcta atttcggcag aagaaacacg 657121 caatctcaac aatctcttac caaatctttc taagaaacca ccgaaggcgg cttcgacatc 657181 ttctggagag atatcaaaca ccgcaatgaa gttgatgaag atatgattca aatcagaatt 657241 tgaagtgtcg gtgacttcta aattatccaa tatatcactc atcaatctgt tagcttcaga 657301 agtcagatat tcttgaatag aaatgtcatc acggatatga cccgttctaa taatacctct 657361 tgtaaagaat ctcttatcca atggagaagt cttactaaca gcttcgtaga catggatgtt 657421 tctattatca gtgaaaattg gtttaatgtt gaagttggac aatcttccta attccagttg 657481 gaaggccaaa gccggctcaa tgtgacgaat tgtttcattt tcgttataat ttggaccgtt 657541 aaaagtataa tactttggat aagacccatc tttaaaaccg aacataaatg tgatacgacg 657601 gatagaagca ttgattaatt cctgcttatt caaatccaaa atttctctca accttaccaa 657661 aatttcctct tcagattcga aaccttctgt agaagcaaca caaacattag caacattact 657721 caacgatgcg gagctaccag aacgatcagg agcaggtccg ttagaagaag attggtgacg 657781 aggaataact tccaaacttt gtgacaaaat ttcatcaaca tcatctaaat gatccacagc 657841 catcaaaata ccttctctta acggagatga ctgactgttt gcaacatatg acaaatctga 657901 aacagaaaca gccctgttca tacccatttt agatttaaca gttggaaagg tggagaacgc 657961 agctgaaggt agttggaatt tccattcaac aattggaact gtgacacctt cgtgaactct 658021 aatatctcct atggtgtaag cacgataagc acgacgaata tagacttgag cagctgcagc 658081 agtcacaact gggtcttgat gggttaggaa ttgaagtaaa acatcgaaca caacgtaatt 658141 agaatcgatc aagtccttca agatattcaa atctggttca gagcgctttg gattggatga 658201 gccataggca accttcacaa cagaggattt taagatatgt tcaatttgtt cagttctttc 658261 cttgaccgaa ggtaaagcgc cttgaatcaa aatttctctt gcttgtagag cgaccttagc 658321 ggtagcctta gattctagtt caacaatatg ttgtagagga gtagagaaaa tggcagaaac 658381 tttagaagat aacttgcaca atggttgata atgtttcaag atagctagga tcaggttatt 658441 cttcgctgaa actttcgaat gagacaaaac agttagcgca actttatcta gatctttagg 658501 gttttcatca cgcaatttca gaatgatatt ttcctcacga acatttggac cattgaataa 658561 cttttcaact tcgtaatatt cttccaagaa atggacaaat atagaatgtt catgggcttc 658621 taacccgtta gagtacttat gagcaatatc cgccaatggt tccacgacgg cgcccagcaa 658681 tttgtcgggg ttgtattcag gattcttcac ggccatatca atcaatttac ttaattgtct 658741 agctgggaaa acagcaccac gtctcaaaga acgtgcaact aactcttcca tttgttcatc 658801 tagcttagca ggcaatcttg aatgtaaagc agagatgtgt agtttccatt ctgagtaagg 658861 cagttttgga tttctcaaaa cctctatcaa ttgttgcaag gaagcgttca taataacttg 658921 gttgtcataa cccttcaaaa tgttttccaa agtagacact aatgacttga atttataggc 658981 aggtttggtt ccttcgataa ctggagaacc aaaatctggc agcatacctt caaatggtag 659041 agcgtgcttg accttggatg gatcgtcaag agtcataata gccatgatat cacctgcaac 659101 aatggtagaa ccaggttgct ttaataactg gacgatacca ttttcttgag aaaccaaagg 659161 catttgcatt ttcataactt caatttctgc atatggttgg cccttgataa tgtgttcacc 659221 attttccacc aagaatttaa ccaatttacc aggggatgga gtacgcaact gggttggatc 659281 gttttcaact tccaacaaag tagtcataga gtcaacggat aatcttgtag cagcaacttc 659341 ttctttccaa tagatggtat gcgatttacc gcctatggca atcaaaagac caccatcaga 659401 tagttgacgc agtatgatat cacatttaga accattgata aataatgtgt aacggtcatt 659461 accggattta gctacggtga acttgtatct tttaccctca tggataaaat ctacagggaa 659521 catagtttgc agtaggtctt tagatagaac ttgtcccttt tgtaaggatt cgatatactt 659581 gtggcgggct tcttcagatg ctaagaaagc ctttgtagcg gcaccgcaaa tgacggcaag 659641 agttggatca ggcttttcag cggtcatttt atgagtaatc aaatcgtcca accaaccggt 659701 ggtaatagtg ttatcctcga aatcttcagt ttccaaaagt ttgatcaagt attccacagt 659761 agttctgaaa tcacccctaa tggacaattc cttcagggca acaaccatgt gtttcctgga 659821 agcttgtcta ttttcaccaa aagcaaaaat atggccgaac tgagagtccg aaaaggagtg 659881 aatattacca ttgttaccca cggagaagta accccaaaca ttagaggaag aacggaagtt 659941 tagttcatgc aaagtaccac ccgatggctt gaatccatcg tttggatctt ctgatgtgat 660001 acgacaagcg gtacaatgac cctttggaat aggtcttctt tgtttcttgg tggcatcttg 660061 agttttgaat tcgaaatcga tttctgaggc agaatgagga ttcataccat ataaagttct 660121 aatgtcactt attctatgca tagggatacc catagcgatt tgtaattgag ctgcaggtaa 660181 gttaacaccg gagaccattt ccgttgttgg atgctcgact tgtaatcttg ggttcaattc 660241 taaaaagtag aattttccat catcatgaga atatagatac tccacggtac cggcagagac 660301 ataaccgact agtttcccca gtctgacggc agccttttcc atctcgtgaa atgtttcagc 660361 cttggcaatt gtaactggtg cttcttcgat aattttttga tgacgtctct gaacggaaca 660421 gtctctaccg aacaaggaaa tatttgtacc gtactgatct gctagcagtt gaacttccaa 660481 gtgacgcgct ctaccggcca acttcatgat gaaaatgggg gagcctggaa tttcgttggc 660541 tgcctggtgg tataaagcga tgaaatcttc ttcacgttca acttgtctga tacctttacc 660601 accaccacct tcggatgcct taatcatgac aggaaaacca atacgcttgg ccttttgtaa 660661 accatcttca ggagaggtac aacaaccctt ttgatagatg tcatcgtcga cagagaccag 660721 accggttttc tcgtccacgt gaacggtgtc aacaccggta ccagaccatg gaatacatgg 660781 gactttagca ctttgagcga caatggtaga ggagatttta tcacctaaag acctcatggc 660841 gttacctgga ggcccaataa agatgacttt cctcttagac tgggacaatt tttcaggcaa 660901 tagtggattc tcggaggcgt gaccccagcc agcccatacg gcgtctacgt ctgctctttc 660961 ggcgatgtct acgatcaagt ctacgttagc gtagttgtta ttattagtac cacctggcac 661021 ttcaatgtat tgatcggcca tacggatata ttctgcgttg gcctccagat cttctggggt 661081 ggccatggcg acgaattgga cggttctgtc atcgccgaac gtctcgtatg cccattttct 661141 gacggatcta atttctttca cggcggcaat accattattt gctatcagga tcttggatat 661201 gaccgtgtga ccaccgtgac tcttaacaaa gtcccttaac ggggactcct ctagtttatc 661261 tactgtattg aggccaatga aatgacctgg aagttctgta tgtctttctg agtagtttgt 661321 aatttcgtac tccatcttct gtggagaaga ctcgaataag ctttcttcgc tcatggtaga 661381 aacttgattt tttctaattt tctgcgctgt ttcgggaacg gaaaaaaatt aagctagaag 661441 acgaatcggt tattatacta ttatatttgt atagtatagt agcgtgtcgt atcgtatcgt 661501 gtcgtatcgt atcgtatcgt taaaagaaaa tacacgaata aataataata tgtggagaag 661561 aaaaagggaa gtttcttgtc tcttgctctg aatctgaatt ccaattcaag ttcaaattgt 661621 tctctagttt attgtccaaa aataaggatg aagcgggagg gaagggcaga gggaaaagtt 661681 cgtatagtag aatgaataaa cttttataaa cacatgcacc gatcactcac agaggataaa 661741 aaaatggcac aacaaatata tatatataga tgcaaatggc gattgcaaat tagggaattg 661801 gctttgttgt tttttatctt caggtaaact gtacgaaagg gataaaaaga gtagaataag 661861 gaaaggaaaa ttgaagagag cagaacaatt gtagaaccga taacaattgt gacagtgatt 661921 gtgctaggct atactgtgcc agaatacgac tgggagtgct gttcttctta tatatcttgg 661981 cgctgattga gcgtatagcc tagttcacca agcagtagag agagtggcaa tgagcggttg 662041 aatttcgact gcgacttgtt ggcacaacgc gcgcgcggcc gggccatgtg aagattttaa 662101 cgggcgcaac gattcggtgg gcagtggaaa ttgttgggcg ttgttcaaca agatgaagca 662161 ttcccctttg gataacgtca acgcatatcg ggccaaccta caggcaatga gcgaaagcga 662221 ctgaagccga gagatgtgcc cggagtttgt tgttcttgtt cttgttcttg ttcttgttct 662281 tcttgacgga tgatactagt cgcagtcgtg gtgactctgg agggcgtaac ggccgtgatg 662341 cggcctgagc tcactgtgac gtcgatgcat gcgcgggttc gttgcgttca ggcctgacgg 662401 gcgattcccc accaagtata agtgtcatga tatacgcggc acctgagcag cacattaggt 662461 cccaattcaa cccaacatat ataatggttc tgtatgggta ttttaagtgt gcaaacaaaa 662521 tgtgagttac ccggctgttt gctagtcgct gcgtacgaac tggcttgcta aagctgggta 662581 aaaataattt aatcgcaaaa ggaagaaaag gaaatcgacg attcattgaa aaaaagagaa 662641 aatactgaaa aaaaaaagac accgacaaaa aaaagagaga aaggaacctt tacgtagagc 662701 aaaagggaaa catttgttgc gtttaattaa tagaaataat aggttattgc attcgccctc 662761 cattgcagaa aaaaaaaaaa aaaagaccat tttcctcttc tactctcttt gcctgtacat 662821 actacacgtt atagcgttaa caaaagcaga tagaaaaaaa aaaaataacc aagataatat 662881 aggtatactt gtttaacaga tcacacacaa tcatgtcgtg gctttttgga gataagacac 662941 ctaccgatga tgcgaatgct gccgtgggcg gccaagatac aaccaagcct aaggaactat 663001 cgttgaagca gagtttaggt ttcgagccaa acatcaataa cataatatca ggtcctggtg 663061 gaatgcatgt cgacaccgct aggctgcatc ctttggctgg tctagacaag ggtgtggagt 663121 atttagatct ggaagaagaa caactatcct cgttagaagg ctcacagggt ctgatccctt 663181 cccgtgggtg gaccgatgac ctatgttacg gtaccggtgc cgtctacctg ctgggacttg 663241 gtatcggagg gttttctggt atgatgcagg gtctgcagaa tattccgccc aatagtcccg 663301 gaaaattgca attgaacacc gtcctgaatc acattactaa gagaggtccc ttcttaggta 663361 ataatgcggg gattctcgcg ttgagctaca atatcatcaa ttctacaata gatgcactaa 663421 gaggcaaaca tgacaccgcg ggctccattg gcgctggggc cctcacgggc gctttgttca 663481 agtcttcaaa aggtttgaaa cccatgggtt attcctcggc aatggtggcc gctgcgtgcg 663541 ccgtctggtg tagtgtcaag aaaagactac ttgaaaaatg agcaacacaa gaacctactc 663601 tctctctctc tttctctctc tctctccctc ttcgcttttc ccccatgcac tgatggcgct 663661 tgtatatagc atttgaaaaa taatagtacg taacgcagaa aacaaaccaa tgaaagtaga 663721 aacccggaga aaagatctaa aaaaacaaaa aaaaaagatg gaaagagcgc atgtatgtgt 663781 agatatgtac atatatacaa ctacttgtat gttatttgcc ttttgtactg ttaagctatt 663841 gttttcgatg gccaattaaa gtaaaacaaa ccgctcactc tcgggtattt cccgaaactg 663901 tcagagccgt cccggcccac cgattcgccc ggcaagacct gcttggaagc agcacaaagc 663961 cctgcggcct ctgtacacct cacgctaaat agctgctaac gatcaacacc tgaccgagat 664021 aacagcagca aagaacccgc aaaaaactgc gccgtctagg cctcaaccct tgcttcctac 664081 aaccaaacaa tggtaaaata tacaaaaaaa agaaaagaat gctctttctt atttcccttt 664141 taacctaacc atcttttgtt ttttgtcgtt taacctggaa agaatgttct attatataaa 664201 cactctttac tacgtcttta gcttgaaaaa actcttgaca agtgcaccga tactcaccaa 664261 catcgcacaa tgaagatttt aacccaagac gaaattgaag ctcatcgctc acatacgcta 664321 aaaggtggta ttgaaggtgc ccttgccgga tttgcaatct ctgctataat tttcaaagtc 664381 ctaccaagaa ggtacccaaa attcaagcct tcgactctaa catggtccat aaaaaccgcc 664441 ctttggatca cccctcccac ggtcttgact gctatatgtg cggaggaggc ctcgaacaat 664501 ttcgacgcta caatgtacgg atccggttcc tcctcggaag acgcactaga tgagcacaga 664561 agatggaaga gtttgagtac aaaggacaag tttgtcgaag gtctatctaa taacaagtat 664621 aagatcatca ccggtgcctg ggccgcttcg ctgtatgggt cgtgggtaat cgtgaacaaa 664681 gaccccatca tgaccaaagc tcagaagatc gtgcaggcaa gaatgtacgc tcaattcatt 664741 accgtcgggc tgctgctggc ctccgttggt ttgagcatgt acgagaataa gttacatcct 664801 aacaaacaaa aggtcaacga aatgcgccgc tgggaaaacg cactgagggt cgccgaagag 664861 gaagagagac tcgagaaaga gggaagaagg accggctacg tttctaacga agaaagaata 664921 aactccaaga tcttcaagtc gtaaacctcg tcggtttatc tgcctcaact ttatttccgc 664981 tcctcgtctt ttataaaatt cctttcatca atacatctat atattcgaat atatagataa 665041 accaatacaa aaacatactg aaattttttg aaaacaacta aaactattca ttgcagttac 665101 acgtgaatgc taaactttat atcgctcttg tcggtcccgc ggagttaaca tttaacggct 665161 tctcgcgcaa taaccggaaa aattccaaca gtttctttgt aatattatta agccttcttt 665221 tttcccggaa tctataagag gggacgaaaa ttagccgcta ttaattctgg tattgccacc 665281 tagacaagaa gtaaacagac acattacgtt agcaaaagca acaataacaa acacaaccat 665341 ggacaagaag aaggatctac tggagaacga acaatttctc cgcatccaaa agctcaacgc 665401 tgccgatgcg ggcaaaagac aatctataac agtggacgac gagggcgaac tatatgggtt 665461 agacacctcc ggcaactcac cagccaatga acacacagct accacaatta cacagaatca 665521 cagcgtggtg gcctcaaacg gagacgtcgc attcatccca ggaactgcta ccgaaggcaa 665581 tacagagatt gtaactgaag aagtgattga gaccgatgat aacatgttca agacccatgt 665641 gaagacttta agctccaaag agaaggcacg gtataggcaa gggtcctcta actttatatc 665701 gtatttcgat gatatgtcat ttgaacacag gcccagtata ttagatgggt cagttaacga 665761 gcccttcaag accaaattcg tgggacctac tttagaaaag gagatcagaa gaagggagaa 665821 agagctaatg gccatgcgca aaaatttaca ccaccgcaag tcctccccag atgctgtcga 665881 ctcagtaggg aaaaatgatg gcgccgcccc aactactgtt ccaactgccg ccacctcaga 665941 aacggtggtc accgttgaaa ccaccataat ttcatccaat ttctccgggt tgtacgtggc 666001 gttttggatg gctattgcat ttggtgctgt caaggcttta atagactatt attaccagca 666061 taatggtagc ttcaaggatt cggagatctt gaaatttatg actacgaatt tgttcactgt 666121 ggcatccgta gatcttttga tgtatttgag cacttatttt gtcgttggaa tacaatactt 666181 atgcaagtgg ggggtcttga aatggggcac taccggctgg atcttcacct caatttacga 666241 gtttttgttt gttatcttct acatgtattt aacagaaaac atcctaaaac tacactggct 666301 gtccaagatc ttcctttttt tgcattcttt agttttattg atgaaaatgc attctttcgc 666361 cttctacaat ggctatctat ggggtataaa ggaagaacta caattttcca aaagcgctct 666421 tgccaaatac aaggattcta taaatgatcc aaaagttatt ggtgctcttg agaaaagctg 666481 tgagttttgt agttttgaat tgagctctca gtctttaagc gaccaaactc aaaaattccc 666541 caacaatatc agtgcaaaaa gctttttttg gttcaccatg tttccaaccc taatttacca 666601 aattgaatat ccaagaacta aggaaatcag atggagctac gtattagaaa agatctgcgc 666661 catcttcggt accattttct taatgatgat agatgctcaa atcttgatgt atcctgtagc 666721 aatgagagca ttggctgtgc gcaattctga atggactggt atattggata gattattgaa 666781 atgggttgga ttgctcgttg atatcgtccc agggtttatc gtgatgtaca tcttggactt 666841 ctatttgatt tgggatgcca ttttgaactg tgtggctgaa ttgacaagat ttggcgacag 666901 atatttctac ggtgactggt ggaattgtgt tagttgggca gacttcagta gaatttggaa 666961 catcccagtg cataagtttt tgttaagaca tgtttaccat agttcaatga gttcattcaa 667021 attgaacaag agtcaagcaa ctttgatgac ctttttctta agttccgtcg ttcatgaatt 667081 agcaatgtac gttatcttca agaaattgag gttttacttg ttcttcttcc aaatgctgca 667141 aatgccatta gtagctttaa caaatactaa attcatgagg aacagaacca taatcggaaa 667201 tgttattttc tggctcggta tctgcatggg accaagtgtc atgtgtacgt tgtacttgac 667261 attctaaggc atcctgcaac tgttctgtgg agctattaaa tctttatagt aaattttttt 667321 ttactttttt tttttttttt tttttttttt attatttaca agcgtctata tattttctat 667381 tatagaatat tgtcatttat tacattggtt catctgtaaa tctcatcaaa cggtctcgta 667441 tcggcgaagc aactgtccca aacttcatct acaatttttg ctgcatgttc tttgctttgg 667501 cagttggggt tccccgaaac actaattatt gccctccttc taacacaatc ttggtgtccc 667561 cttgccacat ggaatcctgt cctaaaccct cttctcttga actcttccca aaacctgcat 667621 tccccactta acgaagaggc tctgatttca gaacatgcat gatgcttcag atttaaccaa 667681 tctatttgcc attttagatc atcgaaataa tgaattaatt catgcgaaag cgtatcctct 667741 aaatgccact tatcacgtaa cctgttctgg cacaatagga ttcccaattc aggatgaaag 667801 ccaccgccct tccagtcggg acagtaatcg cagatgatct tcgaatcgtc gaatttactg 667861 tcgctaccct tattaagttt cgtaatagct tgtaccataa agcgaactgt gggagagtat 667921 ttaagcatcc aatctcgata ctcataacat ttcagacatt ccttttttag ttctcgagct 667981 ttagagtcgt cttcgtatcg agttttctcc tccggtgtca agcctatacc agtcttgtac 668041 tgcatggtcc gtctccacca ctcaaaccca gcattatccc cactgctatt catatcgtgc 668101 caaaaaaaaa aaaaattcgg tactatcagc tttccttggt tttggttgta caaattatgc 668161 cttactcttc tgatcatttt gatattagaa ctcttatttt tcttatttgt tcgcatcgtc 668221 ataaatgata attggcgaaa acgcgccaaa aagtgaaaaa gtgagaacta cttgaaaaaa 668281 aaaagtttga tattataggt attattgctc aaataggtac gatattgttg taggcataaa 668341 aattagatta gcagaaccct tttccatttc attaacatgt ctagttcaat atttggccca 668401 cttacgggtt ttttggagcg tgtcaattca ctcaatgcgc cctaccaagc attatcatat 668461 gacgaacaaa aggccatgac tatttggcaa agagtcaaat tctacaactg gacttttgaa 668521 ttgtgtgctc taggtgtgtt gttcttggtt tatgctttct acaaatttgg taactccgtt 668581 aatttgaagc gcggaaatca gattttccaa tctttgcatt catttttggc caacgactta 668641 aagttctccc gtgtagggtt caatatcaat gattccaaaa tctttacagt ggaacaccaa 668701 aatacatggt tctcttcttt tgctaccggt agatccgcca tcaagagcat caacctaaac 668761 cttcatctgg tagcccgtag caaccctttc tctatgtgtc tagagtacct gcttggattt 668821 ttttttgcaa gtttgaaaag taagcaattg gaagaattta tggagatcgt gatcaggcca 668881 aatggtattt tagttactag tgaatctgct catcctaaca agaatgcgca tgaaattttg 668941 accaaattta gatttgtcac ttctattgtt aacaaagaat tcatgaatca agctagaact 669001 gaaaactatt tcctgtctat tgcacacact agtgaaaacg ataaactacc aaataacttc 669061 gtctacatgt ccgatgttaa tcaattatca gggttcatgt ttcattactc caagccctat 669121 gaggttttgt cccaagctgg taatcttttg aaatatataa gtttcaccga tttgcctgtc 669181 aacccgccac gcgatgataa agaatgggaa tcttcaattg aaccaaaggc tatcattcgt 669241 tgcgctgttc cccaaaatga gaatgaattg aagttgttaa accaaattat ttccttagtc 669301 gtagaaatct acgatgggtt cactcaagat ttagtccaac agtctccaaa cttattcatt 669361 accaacgaca tcttgaaaag aactaccaac ttgcgtcagc aagaactgaa caagatcaaa 669421 aagtttatga aagaaactga attggaattg gcaaaggaga agaaattaga attggaaaaa 669481 gccaaaagac gtcaattgaa ggcctctggt caacaagaaa aggtagatca aaaaatgaaa 669541 gagaaaagag aaagacgtct caaaaacaag caaagaacaa gatttcagta agaaccactt 669601 tgttcttctt tcctccttat aattttctga acctcttcag tttttgtata cgaacgtttt 669661 ccatgtatcc atacatttaa atagtaagta tgtaaattgg tatgtggtgt tttgaattgc 669721 gatgttgcct atatacaaga ttgtacgcta tctgaataca tactctttac caatcaaatg 669781 tcaagaccgg ggatcttaac ctcttcgata gtaatcccag aatccaataa tcccttcttt 669841 tcctcttttg gcttctcttc tttcttgtgg ccaaaaacag attctttacg taactccatg 669901 ttcttttgaa cttccgtttc atggcgttta gagagctgtt gatggtcttc ctctagcttt 669961 gcctcaagtg tttggtattg ttttaacagt tccgtattta tgtcgtgttc ttcgctgagt 670021 atgtattttg caccattgaa gttatgtaaa tagtttctca ttaaagatgg tttgacattt 670081 gcaacttgtc ctttatataa ttgaaatcgc gggaaatcct tcaggacttg aaccttgacc 670141 ctgtgggttc tctttgtcag agcgctcaga cacacctggg tgcaatgtag catctttggt 670201 cgacctgttt cgttcgttat ttagttagcc ttttatattc cttacggtat aacgtaactt 670261 aactgccctt tgagtttgct ttttcatcgg aaagaacaaa tgaactaaaa acttgcaata 670321 ataaacaaaa aaaatacaaa ataacgtgga tgtattaaac caaaaacaaa ataagacaac 670381 tctaaagctg tcaaacagag atctaacgga ttgaaccatg tccaaagtaa tgaaacccag 670441 caacggaaaa ggttctagaa agagttcaaa agcagccaca cctgatacta aaaatttctt 670501 tcatgcaaag aaaaaggatc cggtgaacca agataaagca aataatgctt ctcaaattac 670561 gccaacagtg ccacattctc atccatcaga tatggttatc cctgaccatt tagccgaatt 670621 gattcctgag ctgtattctt tccaacaact ggtggattcc gagaaaagat tagatcattt 670681 tattcatctg cgaaacttac atatgaagcg aatggttgcg cagtgggaga ggtcaaagct 670741 atcccaagag tttctttatc ctcatttaaa ttttccaaat gtaaaatttc tccgaatctt 670801 catttcaaat gttagtgaaa accaaccctg gcaaatggac acaaacaatg aggctgacct 670861 tatggcactg gagaatgcca cttggacgat gagaatcgaa ggtcgattat tggacaatgt 670921 gcaagctaat gatccagcaa gagaaaaatt tagctcattc atagaatcga tagtggtaga 670981 cttcaaaaat aaggaaaacg ataatgtgcc atcgactaaa tttaatgcgg cccctgaaga 671041 aaatgccacc gaaggaccca gtgataagaa attgaactta aacttaccgt tacaattttc 671101 actgccgaat ggtgacaact ctactacgac taataccgac caaaataatg ccacgatggg 671161 ggaggagact gccaaaaagg atatgagttc tacaactcca aaactagaat cagtgaaatg 671221 gcagtatgac ccgaataatc ctgtagactt cgatggtctc gatattaaga gggtagggtc 671281 tgaaaatgta gaatgcacta taagcatcct gcgaaaatca tccccagaag agccatttat 671341 gagctactct ccacaactaa ccgcaataat aggattgaag agcggtacat cacatgatgc 671401 aatattttcc atatataaat acatccattt aaatgaattg cttaccaatg atgagtctgc 671461 attcgaaaat ttgatgggca acaggaacaa tcacaatagc aacaccagta ctagtaagat 671521 gcttgatgca gcctccagtc aagtttctat tgtaaaatta gacactcagc ttattacctt 671581 attacccagc agtcttaaag aatcttctcc agatacaatg aaattaacgg atttactgtc 671641 ccttattaat agtactcacc tgctcccatt acagccaatt gaaattgatt acacagtacg 671701 cgttgataaa gcttccactt atggtgagtt ggttcttgat attgaagtac ctgatgtcaa 671761 cgctctaaaa ttcaataata cacaaagaga aagtcaaatt ggggctgctg aattgaatga 671821 aaatgccagg gaattggaac aaatcaaacc caagatagct ttacaggaca aagaaataac 671881 gtccgttctc tcgaatctac acgagagcaa caaacgatac cgtttcttca agaaaattag 671941 tgaggaccca gttaaagcat taaatgaatg cattgcttct acctcgaatg ctttgaaagt 672001 tttatcggga gatgagggct ataatgaaga tatggtaagg cgggctaact tttacaagga 672061 aaatgaagct atgttgcgcg agaatataga agtcatatta tcaaatggac gaatgtaggc 672121 ttctttacat tgatacacaa tagactgaag atttatgtag ttttctttgt atataaactc 672181 tagataggaa aagaaaggtc accattcatt tataataatt aaagacgaac agacaatgct 672241 gatttgttta tagcgcctac aagtaatggc ggctgtctga ttccattgtc tctttctaag 672301 aaaagcgctg aaaattttct actggaaatt tcagaatatg aaaaagtagt agagatgagg 672361 gccacttaaa cacaataagc atataaggaa ccaagggaaa agcaacaaat gagtgctaac 672421 aatggtgtca ctggcaaact ctctagtaga gtcatgaata tgaagtttat gaaatttggt 672481 aagacggatg acgaagagag ttccaactcc aatacgccgt ctaatatcaa ctcagatgtg 672541 gaacctatag agcagaaagg taaactcttt ggtctggatg actcagcgtg ggacctcaat 672601 agctacaaag atgatttaaa aaaaatttca ggtaaggaga agaaaaaggt gaaaagagta 672661 gtatataaga agcgacccaa tctcataatc tccaacgttg gttacagtga actgcgaaaa 672721 cctgagggtg tgataagtgg gagaaaaacc tttggcgata attctgatga tagtggttcc 672781 aggaagagaa agtttgatga aggcgaacaa aatgaagacg agaaaaggga tgctaaggat 672841 aaggaattta cagggagcca agacgatgga gaggatgaat atgacctaga taaattattt 672901 aaggatagca tcaaaaagaa aaagaccaac cataatggta aaaataaaaa tagaaattca 672961 aaaaagtagc gcagacaatg caccagcaga agtacgtatt cgtatataat aatgagaaca 673021 taatataaag cattgtgtag tatttttttc gtatttgtca taaaccataa ggactgccgt 673081 cctttctatt acgctcaatt ccaaaacata tacaaaaaca tgtaaataca ccacttctaa 673141 tttatcagat aaatctctat catcaatatc attgagatcg tttttgtatc tttgcgtttt 673201 ttttcatagc ttgagtgtcg tcactctcct tttcgctact tcattattgc tacctcataa 673261 ctttctctca agctcaagca tcatctattt ctcgaaaagt tgcgttggtg atctcaaact 673321 ctgcccctcc agtattaata atgttacttt cagtacataa gacttcagtt ccattcacag 673381 aactcgtctc atgcacgcca tgcactttta tggaatctac gctaggtaca gatgtttttg 673441 taccgtggtt gccaaacaaa gttgtttgat gtaagtcttc atcaactacg tagggcgaag 673501 agatggtgtc tcttttcgtt agaaaattgt ccttcgcgta attgaaaagc atggaatgca 673561 aattgtgctt ataggagaac tgtaaaatgt aagaaagcag cacaataagg atgaagttgg 673621 tgaaaaattt agagattttt tgtttcattg aggtgtagtt ggcgtagtta agcggtaatt 673681 ttattatgtg gatagtgttg gctgccgaaa cactcgccac atatgtagag tccggagaga 673741 tagtgacctc tgtaatggca aaactatgag cttgtttgaa tattttagac attgacaggt 673801 cttttagttt cacaagagct atggaattgt cattacttgc cagtaccgcc aattcaccct 673861 tcatgtcgac atccatagaa gtaatccctt tgaatctgtt tgtcacttgt ttggatctta 673921 atacggaagt gtttcctgat ttgatgctta ttttggtcag cacaatacct ttcccttttt 673981 ttaaagaggc tgctatcaat actgtgtcat cggctatgaa gtttatttta gataaactcc 674041 aattcttatc aaaatctgtt ttcctagcaa tgcaacttcc agtcactgtt gaaatcactt 674101 ccaagctaga accggtgata taagcaacaa ccttaccatc agtggaaaag tgtaaatcct 674161 ttacttcacc cctagtctcg atctcaaact tctctgtcaa gtcgctcggg tcaatgattc 674221 tcattatagc aggtacttta gatgatgcga tagctgcaac ggtaccttct cgtgaaatat 674281 aaaccagctt cgtgtagtca tccgcatttg tagatgcgtc aaagtctaca ctagtgagga 674341 actccaattg atcattcact ttatcgtatt taaattttct caagtgctta ttacctttac 674401 cttgggtaat cttagtgcta ttttcattgc agccaaccaa aatgataccc ttggaagcgt 674461 caattgcagt aggagagtcg tcgttgtctt ccaatgcaaa ctcgctcaat atatgaaact 674521 gttccttctc agtatctttg gtaggatcca cgcgcaagac cgtcagcttg tttggtatgc 674581 cattgtttcc ttctcctcca ccgcctgcca caagtaatgt gtcgttattc aaaaattttg 674641 caccgtacgc aggatacccg acgttataac tagctgtcac gaacttcata gtggctcgat 674701 tgtatctcaa ccttgttata tatctgtatt tctatcacgt atccttctag gtttctgtac 674761 acgtttttga attttttgga tttttttttt ttcaactttt cttttttccc tcattcttac 674821 tctattgtca tcaccattca agataaagat aataactagc tttgagaaat tagaccagac 674881 gcagtggaag gttgaataca tgcctgtgtg agggtggtgc caatgaccag tacattacat 674941 acgacaaaaa aagtgctctc cattcaatca cacgtcatac atggctacgt gggaaacaag 675001 gccgctacgt tcccacttca atacagaggt tgggatgtgg acgtattgaa cacagttcag 675061 ttttctaacc actcggggta cgcccacttc acaggcttca aatgcagcac tgaggagttg 675121 gtagacattg tagagaaggg cttgattggg tctcttagaa tcaagtatga tgccgtactt 675181 agtggctatt tacccaatgt tcaagccctg caaaaggtag caggaatagt gggtcaatta 675241 tgtgagggga gtgaaaacgt caagtggata ttagatcctg tactgggcga taatggaagg 675301 ctgtacgtgg atcgagaatg tgttgcggta taccaagaca ttttacaaaa cttcaaaatt 675361 tttttggcca caccaaatca gtttgaaatg gaactgttgg tggggatgtc aattcgtacc 675421 ttagacgacg ctaagcaggc atttaaacta tttcataaaa agtaccctcg agtaagccga 675481 atagttgtca ctagtctgga attatctgaa ttcctgagca acgacactta cgtagtagca 675541 gggtttgatt gctcggccag tgaagagata ttcttctatg aaatccccaa gatcaacgca 675601 aaatttagtg gaagtggtga tttaatcagc gccatgctca ctgactcgtt actaggcgac 675661 cgccgctgca cacagctgtc attaagcgca tccttgggcc aagtgctgtg gctcgtcacc 675721 agtatcctac aaaaaacgta tgatttaaac atagctgagc ggggcccaca agattccacg 675781 atagatatca aggatttaaa gctgattcag tgtagagaca tcctaaagca agatctcata 675841 ccctccattg gcaagccaaa aaccattaaa atatgattct tacgaaacgg tatgctcctt 675901 cctcattggg gtgcggctgc tgcaggaacc tgcctaaata ggaaaataca ttcctgattt 675961 ggaaactgta ggcacacgac gcgtcccttt ggagaagatc gatccttctt tgggtctttc 676021 aatttgattg gaaaaaaaat atttaaaaaa atagaagaaa aatatagaat atatagaata 676081 tatagaatca actactgcag tagataaata aagaagacta ttcatattca gtatcacaat 676141 tgaaagatta ttacaatttg tatacattgg ttcccaatga agagcttttt tctttatctt 676201 tatgtggcat tcatgtttag ttgcataacg gctctgccat tacctgtgga taacaaaagg 676261 gcttcttcag actccttaga cctaaagaaa aaatacgcac cagaccctcc tattacacat 676321 aatgtaaaca tcggaattgt tttcacagat cctgaaagtt cggaagaagc cggccgtctc 676381 ataacaatag acttatacgg gactatggtg cccaagacag taatgacttt ttgccagtat 676441 gttgatagtg taaaagatcg ccttgcttcc cgtcacagtt actcgccaga acgcgatttt 676501 gataaaattc taccgaatgg agctatagaa ggtagctccg tttcttcctc ctctattgaa 676561 gaaacggaaa tgttggctcc aaaactcccg gaagaaaatc atagtttaat tcatgatagg 676621 ccaggcagag tttccatgat taaggacgat aagggtctta agtttataat tgagaccagt 676681 gagacgccac ttgaaggtga aagtgttgtg tttggccaag ttaccgccgg gttaaaagat 676741 ctgatggata aactagctaa tgtgaaaact gacgaaaatg gcaaaccaga gcaaccaata 676801 acaataggtt acatttcatc ccaggaacac aggattcagc atgcaaagga agctcacgaa 676861 aagtatttac aaaggcttca agattaccaa aacggcgatt tggagaaagg tattacattg 676921 aagaattatt tataccaggg tagtcaaaga aagttagaag acgcaaaata taatcagctt 676981 caccatcctt taccaaagat tatgcttggt atttcggtat tgttactttt ctacgttttg 677041 gccaagtaca ggaaaagaat attcaacaga tcgtctaaaa tagtttctat tagagaggat 677101 taaaatgttt cgatccatcc gcttaatatt cattcatttt gtatcacata catacgtata 677161 aatatacata acttacctcg tctttattat gccaaccatc attccagggt tttacgtaac 677221 agttcctcta tggattcctt ttctaggtac ttcccaatca gcacaatttt acactcttta 677281 ttggatccgt catatttgcc tggaaagaca tcgtaggtgt cgcggacgcc ttggattaca 677341 cgagcaatgg ggttctctcc ttcaataagt atcagacctt tagttctttg tacttcccaa 677401 tcacggccgt catctcggcg acgccctccc agcactgtca tggctccaaa attcttccac 677461 aataaaggtt gcaaaaattg cttaataaac ttattattat attcttcctc gttttttaat 677521 ggtctgaaag taagcattat tgtgcccatt cgatcatcat gaatggtacc gtttccgcta 677581 ccactatcta agatgtcaga tatccgtaca ctgtcgtatg catgaatatc tagtaaattt 677641 tgaatcggcg tatcactata cttggtgaag aacatcggtg cgatagaatt tatttcccgt 677701 actctttctt ttaattgttt gaccatttct ggtgaatgtt cgatagtatc gtatttgttc 677761 attataattc gatcagccat ggctagttgg aagtgtgcaa tagtcagatt cccctccaaa 677821 ccaactttgt caccatgcca atgggcatcg atggaaatat catctaagca ttttagtata 677881 tgctcacaat ccaaaaccgt gatgatcccg tcaatgtaaa cgctgctatt caatccttcg 677941 tcctgccaga acattttcgc aatgggggcg ggatctgcaa taccggaggt ctctaaaagg 678001 atataatcga ttttaccagg tgaacgctcc accatatctt cgatggcttt aacacctata 678061 tttttcaacg aacaacacag acacccgtta cccaaatcca accattcttg gtagctgttc 678121 gatccatttt taatggtcat agccttttcg atttcactag aatctccaaa ttcatttaaa 678181 attacggcaa tttttttatc tgcacctttt aatgcaattt tttccagcaa cgtcgattta 678241 cctgatccta gatagccggt aataatgctc acaggaatac gctttttctc gtgcacatct 678301 gttgcgcctg cagaagtgtt ctccacttgc ttgtttaccc tttcaacttt tgcatcgcta 678361 acaatatttc caccatcata cgagacattt tccaaaattt cttgtagatt attttcttca 678421 cctgttacga ggcagggtag ttcaccatct tcttcttcat tgaacttgat gtttctcaat 678481 gcagacattc ttccgcttta aaagttgaaa attcctcaat gaaaagggtg ttcttggctt 678541 tacaagcgca ttaaacattt aatattatat aatatttata atatacatgt tattccaata 678601 gtgaaaaaaa aaaaaaaatg aaaatgaaaa tgaaaaattc ggcccttaaa aatgaacaac 678661 cttttaccag ccggcattaa atgtcgtggc acttcacagt ttataacgca aggaatttac 678721 taatagcaag tgaaaccatt aacgattagt gttgttaaaa gagttgaata aagccattaa 678781 acaacgattc agttgacaat gcgttggtct gtccttgata cagtgctatt gaccgtgatt 678841 tcctttcatc taatccaagc tccattcacc aaggtggaag agagttttaa tattcaagcc 678901 attcatgata ttttaaccta cagcgtattt gatatctccc aatatgacca cttgaaattt 678961 cctggagtag tccctagaac attcgttggt gctgtgatta ttgcaatgct ttcgagacct 679021 tatctttact tgagttcttt gatccaaact tccaggccta cgtctataga tgttcaattg 679081 gtcgttaggg ggattgttgg cctcaccaat gggctttctt ttatctattt aaagaattgt 679141 ttgcaagata tgtttgatga aatcactgaa aagaaaaagg aagaaaatga agacaaggat 679201 atatacattt acgatagcgc tggtacatgg tttcttttat ttttaattgg cagtttccac 679261 ctcatgttct acagcactag gactctgcct aattttgtca tgactctgcc tctaaccaac 679321 gtcgcattgg ggtgggtttt attgggtcgt tataatgcag ctatattcct atctgcgctc 679381 gtggcaattg tatttagact ggaagtgtca gctctcagtg ctggtattgc tctatttagc 679441 gtcatcttca agaagatttc tttattcgat gctatcaaat tcggtatctt tggcttggga 679501 cttggttccg ccatcagtat caccgttgat tcatatttct ggcaagaatg gtgtctacct 679561 gaggtagatg gtttcttgtt caacgtggtt gcgggttacg cttccaagtg gggtgtggag 679621 ccagttactg cttatttcac gcattacttg agaatgatgt ttatgccacc aactgtttta 679681 ctattgaatt acttcggcta taaattagca cctgcaaaat taaaaattgt ctcactagca 679741 tctcttttcc acattatcgt cttatccttt caacctcaca aagaatggag attcatcatc 679801 tacgctgttc catctatcat gttgctaggt gccacaggag cagcacatct atgggagaat 679861 atgaaagtaa aaaagattac caatgtttta tgtttggcta tattgccctt atctataatg 679921 acctcctttt tcatttcaat ggcgttcttg tatatatcaa gaatgaatta tccaggcggc 679981 gaggctttaa cttcttttaa tgacatgatt gtggaaaaaa atattacaaa cgctacagtt 680041 catatcagca tacctccttg catgacaggt gtcactttat ttggtgaatt gaactacggt 680101 gtgtacggca tcaattacga taagactgaa aatacgactt tactgcagga aatgtggccc 680161 tcctttgatt tcttgatcac ccacgagcca accgcctctc aattgccatt cgagaataag 680221 actaccaacc attgggagct agttaacaca acaaagatgt ttactggatt tgacccaacc 680281 tacattaaga actttgtttt ccaagagaga gtgaatgttt tgtctctact caaacagatc 680341 attttcgaca agacccctac cgtttttttg aaagaattga cggccaattc gattgttaaa 680401 agcgatgtct tcttcaccta taagagaatc aaacaagatg aaaaaactga ttgataatag 680461 ctaacgtcaa ttccaataaa atatatagcg agcgttttac attaatccac ctcgactaga 680521 cttcaaattt tcacttttat atcttacctt tataaatttc tgttctcaaa atcaaaacaa 680581 ttataaaaaa atgctatcat taatcttcta tccttgaatt aacattatat actctccccc 680641 cactacatta tattttgatt ttacatataa tacaacaaac cttctcaact taactactct 680701 ctttcctcag tatctgtaga ggaagaatcg tcgccaaagg ctatttctct aatttgtaca 680761 atccaaggat ccatcaacag ctcaaccgca ctggctctct tggaggggtt ttgaataaga 680821 catctttcca gaaatttcat accagcagac gacacttcat ccttagtagg gaattgtggg 680881 gtatgtcctg cagcaacatg gtacatgata gcccattcat tatctaagtt agcccatggc 680941 cgtctaccag tgatcatttc taataccacg cagcctaacg accaaacatc gtctgcccca 681001 agtttgcctt tggtggtaga tccagtgatg gattctggag ccatgtacat aggagttccc 681061 atcatgtcta atagagcatt ttcgttattt ttcactgcct ttgaatcaga aacatgggta 681121 acatcttcgt gttcaccatc tgcgttttcg attttgttca tacttgccaa tctagttcca 681181 ttattagcaa tttttttagc agcaccaaaa tcaacatact taataacacc attaaaatct 681241 agtaggatgt tttcgggttt aacatcacgg tgaacaatgc cggattcatg caaatatgca 681301 agtccttcta gcaattgtaa agtgtagact tgagtgacca tttcatcttc aatacgacca 681361 tgctccaaaa gagctgctag ggaaccgcct tcacaatatt ccataaagat gttaacttta 681421 tcacgatgaa cttcaacacc gtaatatgaa actatatttg gatggttcaa tatctctaag 681481 acactcattt cctccttgat taaggggaat attttttgca ttgatttgct atcttgaata 681541 ttgatttcct tgactgctaa aatctcacca ttatccaaat caacagcaga atataccctt 681601 ccaaaagtac cgccaccaat aaagttcctc ttttgccatc tcatagaaac gttcgatatg 681661 gaagatgcca aagaaacaag gtacttgtta cctttgtcac tatcatcaat tactttacca 681721 gtttgatgag gattccgctt tatcctttct tccaattcca ttatactttg tactcggaac 681781 tcggaattca cttgtagcat catatcatcg tcaaacacat cttccaaatc aagatttgat 681841 ctagcttgtt gattgatttt ctcaacttct atggagcgtg cgcctattat atcaaaatga 681901 gaaataagta atgacatgca ttctgaaatt ttttgtttta aagaagaaaa ttggcattca 681961 tcaagagcta gtatgttcca accgcttacc atatgcatcg cgaactccat tgacgtgaca 682021 caccacctaa ataccctttg atcagtcgga tcacagtctt cagctaagaa cttcagccat 682081 ccgatactta accgcatcat taaaagtatt ataatggatc ttttttcatt gttggcaaca 682141 ttaattctca aaaagttcag accaaaatcc ctcccaaaaa ggaaaatatt attcaataaa 682201 tcattgacag gacttacctt cttgaacgtg gtcacaatct ttgtatagtt cttcagaaca 682261 ctgtacgtgc atctgaaata tgctttattt atcctttgta agttgttttt aaccgtttct 682321 gaggaagatt ttttttccaa gaaagaaact gagctaccag atatctgttg gaacctgtca 682381 cattggtatt ctaaggcata actggatcct tggcacatca aatctattga attaggaatt 682441 actttcaagt tcaatccctc tggtttaatt gttttgttat cggatagatt atacatctca 682501 ccctcccaaa gtaatggctc ttgcggagtc aataccaata cataaccaag agagttcaat 682561 cttgtctcca gttcataaaa ctcttcctcc gtgctcctgc tgttttcaaa atccggttca 682621 cgattgactc tattaccgtt ataagatcta ggctgggtgg tcaaatcgtt tttgatataa 682681 taaaatgggg taccatcatt cgagatatct gaacccagtg atgagttgga gttccaatta 682741 tcatccaaag cattataaat tgtcagactg ttattaattt ctagcttagg cactaaatca 682801 caaccgatgt ctgaattctt aatgattctt aaaatatcat catctttaca gcctaatagc 682861 tctgggctac caattaaata agtaccattt tgctctaggt aacctcctgt gtatataaga 682921 aagtggcctg tttcttttag ttgctttagc agatagttgt gatcttctat cttgtagcgg 682981 acaaaatttt gaaatgcttt tgtcaaaata ttggtgaatc tattgagttt tcttttcatg 683041 gatccaagta tttcgaatat ttgcaccagc catttttcag cagcagcttc attctctaat 683101 tttggcggag tgttttgctg ccttaaaagg taagcgtgca atctgtgaac caatctaagt 683161 gtcaacttcg taaattctgc tgcgatcagt tcgcctgcat catcaatata atagccgacg 683221 tttctaaaca tttcccaata ttttaataac agatcaggtt ctttagaagt cttgaatgag 683281 tttttgccac tatataatat tctcagttcc aaaatggaga aaaaatattc caatccttca 683341 acaacggtat gatcaaattc gggatcgatt ttcactttaa aaaaccagtc attacagtaa 683401 gaagcaacag tgaatttcat ttggactgcc aacttaatat atgtactaaa atcgtccatc 683461 atttgatcga tcatcatcaa ggttggattc tgtattttct tcgcgtaaga taggcgaatt 683521 agtattatat cttttaccaa acgcattgga aacatcaata aaaattccag atcttgatcc 683581 aaataagata gattcaattc attccaagtt ttttggtatt tcaagaagaa aaatttggcc 683641 ttcaaaatcc atggtgctaa tggaaagaat attttttttt gaaatatcag ttcaatatcc 683701 ttttccttca taatttgctc cgcaaagcgt ttacaattag tggcgaaaac ggctggatca 683761 tccaaattca cggtggtgtt atccacttcg gtagtgcttt ctagctcttt attgccaact 683821 atccattttt tcaggtacgc aatattagta tcaaagttaa atttgaaatt aagccaacta 683881 ttcaaagtat ctattcgatt cctgaatgct tctgttttag taatgggttt ttcagcatgc 683941 attcttttaa tgttaggcca tagatttaag actctataat atttgtctac tagtgatttg 684001 atagtctctg cagcctcgtc agcgctcata ttatcttcta gtttaaaggc catgatttct 684061 tgaaatacgg agtcagtaga atccctaaaa atcctcagag atttgttctg atcttccacg 684121 gtcctcccat tcatccatgc cttcaactca atccaaatgt catctgaaaa ctgagtattg 684181 aagccagggc ctttcccttg atttgcaatc ttcgtttttt cattcctcac aatatctccc 684241 ttcagtacct tagataacat tgtttgccat tcaaatcggt tgttcaccat aggattttgt 684301 aacaattttg acagcaaatc ctcgctcccc agtatggaat gccactcctc atcttctatt 684361 tcacacggtt gatcattgtt cacatccctc aaccaatcca atttgccctt tagataattt 684421 aggctcatcg aaacaacatt ttcattattt tttgtgctcg acgtaataaa attataacca 684481 aaattgaagt cgttatcttt atcctcacct tctaccttta aaagatcatc catttctagt 684541 tctaagtcat cttcaccttt gttactaaaa ttttcttcgt catcttcaaa gttggatgat 684601 gcgactatac ctctagtgta ataatcatca ttagcacggt ttctcatttt tcttaaatat 684661 aactgttcat ttaatacata ttgttttttg tatgttcgga ggctcgttgt gcttccacca 684721 tggtggccta cagaccgttg cgagctattt gtcgtgacaa tatcctgcaa agtggaggaa 684781 cttgttgacc catttggttg cgatctggtg ggaatgtgtt tgttcgaagt ttggtttgta 684841 atattttgtg gcgttgacat aatcgatgta ttcgttgtat ttagtgaagc cagttctggt 684901 gatatcacta acgttggggt cgtcaataat ggatcttgat tactattcac gggagcgggc 684961 ttcttaataa tctcgctctc tgttttacta gcctcaactt tcttatgtac aggaacaggt 685021 tgagtagaca acttcggtag agactgctga ggattttttg gtagaggaag accaatattc 685081 gagggccgtc tactagatct tgccgaggag ctggaggacc cagaaatggc attttgatga 685141 aaaaactgac cttgaggtat acccggaaga cgattgaata gctgtactgt atttaatgga 685201 gactctccag ggctgtaaac agcgtttggt gatctaaagt actgggtaga atgcagccct 685261 gggctgatgg gcgatgacgc tactcgagcc tgcgtagtat tggaatttcg ccctaaactt 685321 tccgacctta gtctagatga agatgatgaa gatgactgcc tcatcttgga gctgctgggc 685381 ttttccgtgg aatcgccgta aggcttataa ttgaagtagt ctgaatgcga cattatttgt 685441 gcctgtcaaa tagtttacgc aaaggcttct cttcttttta gtaatggcag actgtttgta 685501 cttgaaactg cccaatagta acttgaagga cagacggagc tcacacaaaa gttaacaaat 685561 atgctggaac cttttttttt cctttgaatt ctttgtaaac cagtaattcg ttttgaaaac 685621 acccgttctt agctgttctt taacagtact actctctaag gcaataacac actggggcag 685681 caacaattac aatcttctaa cctcttctaa tctgcagatt tggcttcttt ctatctctgt 685741 ttacccacct ttatcactct tttcagatta atcaattctt tccatacaaa gaaacgcccg 685801 aaaagtggcg cgagtttccc gggtgatgga gcagtaatta ataatgcaaa actgctaaaa 685861 tacccactgt ttcagggtat gaaacgcggt attttcagcg agttgtaggt aatttggaac 685921 agttcgtgac tgtttattaa gttccactca ttgcagttgt atccccactg tgtactttta 685981 tttttggtta gagaattggc ccagtagaga tggaattgga cgaatgttta gaaaggctat 686041 acaaggccca gttactacct gaagtgactg taagggcact ctgctttaag ctgaaggaaa 686101 tgctagtgaa ggagtcaaac gtgattcaca ttcagacccc tgtcacagtc gtgggggata 686161 tgcatggaca gtttcacgat atgctggaga tcttccaaat aggcggccct gttcctgata 686221 cgaattatct gttcttgggc gactatgtag acagggggtt gtacagtgtg gaaacaatta 686281 tgctattgat tgtgcttaag cttcgatatc ctagtagaat tcatcttttg aggggaaacc 686341 acgagtcacg tcaaatcacg cagagctatg gtttctacac ggagtgcttg aacaagtacg 686401 gtggcaattc aagagtttgg caatatttga cagatatatt tgactatcta gtgttatgct 686461 gtattatcga cgacgaaatt ttttgtgttc atggtgggct ctcgcccaat gttcaaacca 686521 tagatcagat caagattatt gatagatttc gagaaattcc acacgatggc gccatggcag 686581 acttggtttg gtctgatccg gaagaaaaca ataaccccac gttagatcat ccagataact 686641 ctggacaaca tttccaggtg tcacctcgtg gagcaggtta tactttcgga agaagcgtgg 686701 tggagaaatt cttacgtatg aacgatatga acagaatata cagagcccat cagttatgta 686761 acgaaggtta ccagatatat tttgatggat tggttactac tgtatggtcg gcgccaaact 686821 attgttatcg gtgcggcaat aaagcatcta ttctggagct gtatagtaaa gatcaattct 686881 acttcaacgt tttcgaagag gcacctgaaa ataaactgtt gaaagagaac agtatgaacg 686941 acaatgcctt agaagatagc atatctaatc cggtagccaa caggaaattg attgcagatt 687001 atttcgaaga cgactctgcc tccgcagatg gctccacgga ccctgaaatg tacatatttt 687061 cagatgtata ccaagccaga tctgcttcta acagacatgt tgattacttc ttgtagctta 687121 ctaaacaata gaaaagcatt atagagacaa cgccatctta ttatttctac atattctatc 687181 tctctcggtt gcaaatgtat gtattgtgta tttagatcaa aaaaaaaaaa acagcgcatt 687241 ttctacaggt aatacagctc caaatttgtc tgatcatgta cctcataatc ttccagagag 687301 atatggtctt ttaaaacact tccacccttc tgcaacacaa ttttgtttgg ttgggtgcca 687361 atttgcaagg acaatacttt tttgaaatca cctacactat cttcagcaag gcacttcact 687421 ctgacttttt tgcctaatcg gtcattcaca actacctcaa tcattttcag agtatttatt 687481 tgcaatctaa gctttgccac cgctcctctt tctcaatctt ttcctctccc tcctcatctc 687541 tctcagccaa aaccgcgaat atataaaaac aagcaagtct cccgtagaac ttttacacga 687601 tgacctttcg agatttcaca agggggataa aggaatgctg tccgatacaa ttgacacaaa 687661 gcaacaacag caacagcttc atgtcctgtt catagactct tatgattcat tcacctacaa 687721 tgtagtgaga ctaattgaac aacaaactga tatctcaccg ggagtcaacg ccgtgcacgt 687781 gacgacggta catagtgata cgttccaatc tatggatcag ctattgccac ttttgccgct 687841 ttttgatgct atcgttgttg gcccaggacc tgggaatccc aacaatggtg cacaagatat 687901 gggtataata tctgagcttt tcgagaatgc caatggaaag ttagatgaag ttccaatatt 687961 gggtatatgt cttgggttcc aagcaatgtg cttggctcaa ggtgctgatg tcagtgagct 688021 aaatactatc aagcatgggc aagtgtatga aatgcattta aacgatgcag ccagagcttg 688081 tggccttttt tctggttatc ccgatacgtt caaatctacg aggtaccatt cattgcatgt 688141 caatgccgaa ggcattgaca cccttttgcc cttatgcaca accgaagatg agaacggtat 688201 tcttttgatg agtgctcaaa cgaaaaataa gccatggttt ggcgtacagt accacccgga 688261 gtcatgttgt tcagaattgg gggggctgtt agtcagtaac tttctcaagt tgagtttcat 688321 aaataacgtg aagacaggaa ggtgggaaaa gaagaaactt aatggagagt tttccgatat 688381 cctatctcga ttggatagga ctattgatag agaccccata tacaaggtaa aagagaaata 688441 tccgaagggc gaggacacaa cttacgttaa gcagttcgag gtctctgaag acccgaaatt 688501 gacatttgaa atttgcaaca tcatacgaga agaaaaattt gtcatgtcat cttctgtgat 688561 tagtgaaaat acgggtgaat ggtctatcat tgctttacca aactccgcat cccaggtatt 688621 cactcattat ggagctatga aaaagactac agttcattat tggcaagata gtgaaattag 688681 ttacaccttg ttgaaaaagt gtctagatgg tcaagattcg gatttgcctg gctcccttga 688741 ggtaatacat gaagataaat cccaattttg gatcactttg ggtaaattta tggagaataa 688801 aataatcgat aaccacagag aaataccttt tattggaggt cttgttggca ttttaggtta 688861 tgaaataggt cagtacattg catgcggccg ttgcaatgat gatgagaatt cccttgttcc 688921 cgacgccaaa ctagttttta tcaacaatag tatagtcatt aatcacaagc aagggaagct 688981 ttattgtatt tctctggata atacatttcc agtggcatta gaacaatcat taagggacag 689041 ttttgttaga aagaagaata ttaagcaatc cctgtcctgg cccaagtatc ttccagagga 689101 gatagacttc attataacta tgcccgataa acttgactac gctaaggcgt ttaagaaatg 689161 tcaggattat atgcataagg gtgattctta tgaaatgtgt ctcacaacgc aaaccaaagt 689221 tgtaccatct gcggtgatag aaccctggag gattttccag accttggtac aaagaaaccc 689281 ggctccattt tcaagttttt ttgagtttaa agacattatt ccccgccaag atgaaacgcc 689341 tccagttttg tgcttcttaa gtacttctcc agaaaggttt ttgaagtggg atgcagacac 689401 atgcgagcta cgtcccatca agggaactgt gaaaaaagga ccgcaaatga acttggcaaa 689461 agccacacga atcctgaaga caccaaaaga atttggtgag aacttaatga ttttggactt 689521 aatcagaaat gacctttacg agttggttcc tgacgttcgg gtggaggagt tcatgtccgt 689581 gcaagaatat gccaccgttt accaactcgt tagcgtcgta aaggcacatg gattgacctc 689641 tgccagtaag aagacgagat attcaggcat tgatgtcctt aaacactcgc ttcctccggg 689701 atctatgacg ggagccccca agaagattac tgtgcaatta ttgcaggaca agatagaaag 689761 caagctaaac aaacatgtca atggtggagc acgtggtgtt tacagcggtg tcacgggata 689821 ttggtctgtg aattccaacg gagattggtc tgttaacatt agatgtatgt attcctacaa 689881 cggcggaacc agctggcaac tcggtgcagg gggggccata acagtcttaa gcacactaga 689941 tggcgaacta gaggaaatgt acaacaagtt ggagagcaac ttacaaattt tcatgtagat 690001 atttgtatat tattagatat gtatgcaaac attttcttta gaataatata ctattcttgt 690061 acgatgcaga attttttttt tttttcgctt taggaaaatg acgttttgtg ccgtggaaaa 690121 ccctggaaaa ggatattgga aaaaagttaa agcatggtca tttagggaag actttccttc 690181 caatttactt atcaataggt tataatgtat gcttgacgga gcagaattct ttcaaaccat 690241 aagataatag atattataac attttagtac ataaaagagg cccgagaaaa tagattttaa 690301 ctggaataat tttttgcaag atgacaacaa ccgtacctaa agtgtttgca ttccatgaat 690361 ttgcaggagt agctgaggca gttgccgatc atgttattca cgcacaaaac tctgccctta 690421 agaagggcaa agtctcaagg tccacacaga tgtccggaac gagccttaac ggaaatggta 690481 acacagaatc caaaacgatg gagagagtaa attctgtaag gagtaatgcc tccagccgtg 690541 gtggtagtga agacggcgcc actaagaaat tgaaaaagga gaaagaaagg cgcttcaaga 690601 ttgcgttgtc cggtggttcg ttaatccaag tgttgcacga aggattgttg aaaagagacg 690661 acgttcaatg gggtaaatgg gacatttact ttgctgatga aagactagtg ccctttagct 690721 ccagtgaaag caattacggt cttgctaaga gaaaaatatt cgatttaata gatacggaga 690781 agtacggaac tccgaaaatt tatcacattg atgagtcatt gattaacgac cctcaagagt 690841 gtgcagataa ctatgagaaa attctaatta aaggatttgc cggtagagat tctgtgaaac 690901 taccgatgtt tgatctgttt ctgcttggct gcgctcctga cggtcacata gcctcgttat 690961 tccccaattt tcaagagaat ctacgtgaaa atctggcatg ggtcatacct gtagaaaatg 691021 cacccagcgg accttcgaat aggatttcac tgaccatccc agtgatttgt cactctcata 691081 gagtcacctt tgttgtagag ggcgccacaa aggcgcctgt aatcaagaca ataatggaaa 691141 ggcctgaaaa gggattgcct agtagtattg tcaatgaggg cgccgccggt cgtgtttcat 691201 ggtttgtaga cgacgatgct ttgaaagatg tctttgtaat taagaagaag tacaagtttt 691261 atgatgatga gaatttgact gagtaggtgt ttaatttttt gggttctttt tctttctgat 691321 gataatgaca actaatgaca atactatgat ttaaccttaa ccattttctt tttttagctc 691381 tttctatccc cacccttccc tttagtaatc gcaataaatc accctatgtt tttgaatttt 691441 ctcgagaagt aactttatat aaaacaagtc atcttagtga cgtagtgtgc atatataaca 691501 tacaacatat ataatatata caataaccct ttagaaaaaa ataataacaa ccacagtgga 691561 tatttccctt ttggacctat ggcttccgct aagagaaaag catgctttta agttttcttt 691621 tctttcaagg agattatttg gtcttaagcg aagtgagaga ttgaaacaaa atgttaatta 691681 cagagtttac gaagaatcag tttgcaagac caccttattc gtatggcatt atcaagcttt 691741 gtgtgtagac tatccacaca aacatgattc aacatacata gcagtggtag gtatacaacg 691801 gatataaaaa ccttaactct acgtgtagaa aatgtaaaag ggtagagcgg ttgcaaaaaa 691861 gcaagtttta gtaggattcc aggaacagct tctcatcttg ctagataaca tacggcaata 691921 atgacaaaat acactgagcc atgcggttgt tacactttcc caaaatagta atctacttct 691981 cccatttttt atattttgcg tatcacacca catcgtccct caacacaaaa gtttttgttc 692041 ttgttgacaa gactgtcatt ttccccttga gtgactttat gtcgctgatt cattcatttc 692101 ggcattgttt gctgtttatt ccccagattc tttccgcttt gcttggctgc ccctttcccc 692161 ggaagcctcg agattaagat gaaaagacta atagccaggc tgttaacccc ttgttgatac 692221 agtttggaca ccccctacta gttagctgtg tatcctgaat ctatgtcaag caaaaattgc 692281 ttacatacag taaggtattt tttataatcc cgccaacact atgtcgactc cttcattttg 692341 gacatcttct ttacatggac gaaccagaga aggaggtcgg ctcgaaggga atgtaaagct 692401 atcatagggg tataaataag agacacattg ttctattata gagaaaaata ttttatagat 692461 cttgtatctc atcttgcgta atataaccaa acaaaggttt tccttatact atatcaaacc 692521 aaaaaaaaaa aaaagcaaaa caacaaataa tcataatatc atgaagtcaa gtattccaat 692581 caccgaagta ttgccaagag cagtgggttc gctaacattc gatgaaaatt acaatttact 692641 ggatacatca ggtgtcgcaa aagtcatcga aaagtcacca atcgcagaaa taatcaggaa 692701 atcaaatgcc gagttaggta ggctgggcta ctccgtctac gaagatgctc aatatatagg 692761 tcatgccttc aagaaagctg gccattttat tgtgtacttc actccaaaga acaagaacag 692821 agagggcgtt gttcctcctg taggaataac caattagctc agaacagaat tagtgttaat 692881 agcggtgaca gtagttttat tgtatctcac ctttttttat gtataatcat ataatgactt 692941 aattattttt gaaatgtttc tttttttttt tttagttata acccttttta cggattctta 693001 cgtacttatt taatctttct agtagacaat ctttctaccg gtgaaggttc ttcttgcctg 693061 ttgtctgcct tctgcactca attcatcatt ttcatcatct tcgtccacct tggctctatt 693121 taagactttg atgaacgagt ccactctgaa tctcattctg gagtgcatgt aggctttaga 693181 gcactttatg tgataatgga agtagtttct aaacaatgtt aactggcaaa ttgaatggaa 693241 ttgcaactct tttgtctgga aatgacgtgg gaaaagaaca aacgtgataa atcttctact 693301 ttgctctgca actttaggtg gttgatatag tctcttcaac tccaatggtg gttcatgtga 693361 gtataaaact tgtggagcgg attggatttg acggtttctc ttacgtgcat ccacgaattc 693421 ttgtaaaaag accttgccaa aaattttatc tgtttcgtct tgaaaaatag tctcgaagat 693481 tatggtaact ctgtcattgg aaggtttgat gaagatgttc tcctcgtcac gatacttgat 693541 tgtgaacaaa gtgttgtctc cattggcagc aacctcaccg ccagtaattt ctgcttcgac 693601 aggtgccggt tgctgctggc ttagttcaat aaacttcgaa atggccaatt cgaagggaaa 693661 actcaatata atggtcttca aaacagacag ttgtaaaatc gattcttgaa ccaattcggc 693721 caacgtaatc tgaagagtgt agtcatagcc gggctccact tcacttggga tagtcacccc 693781 acccaaagag gagtagtggt cggccagaaa cttcagtaac gtcaaagaac cgtccaattg 693841 gcactcagag acacttaccc aagctttggt cttaacactc aacaacagaa tggacttatc 693901 ttctgctgtg tttgaaatgt ggtaggtggt atagtcgaaa tcggaaacaa ttctgtccat 693961 ggtcaacggc gaacccttgc gaagtgcctc tatcgcttca ttcagtgtct tttggatgag 694021 aaggttttgt ggttgtaagt gtagcattgc ggattaccgt tttgaggcaa gaagattgct 694081 agtcttgtat ctacactagt tcctttgaac gctagttagc ccctatgctt atagtatttc 694141 ttgtcaatac aagcgtctga aaattcagat cgctttatac gagtaagtat gccaaataca 694201 ccaaatatac caaagcattg attgcgtata ctgagaatac atatatatat atatatatat 694261 atatatgtat ggtcattgct atttacaaaa ggttgtatgg agtgggaata ttagagaaaa 694321 gtagtcgaga ggccaaagaa aacttagagc gtactgcgca tcacgattta cttggcttct 694381 tggctccata tttcgacctc gaagaaatcc tgtttaccac accactcagg tcaccagcac 694441 ctctgataac atggtacttc acaccaggca agtcctgaca acgcccacct ctgacatata 694501 caatcgaatg ctcttgagca tcgtggccct cacccggtat atatgcagat accacgttcc 694561 cgttagtcaa acggaccctg cacgcctttc tctgcgcaga attcggcttc ttgggcttta 694621 aaaccattac acgtaatacg acacccttcc gctggggaca ctgatccagt tgtggagctg 694681 tacttatctt cttgcgtctt ggaggcccgg agcctctttt aatctgattc aatgtcgctt 694741 gcattgtcgt agtggaggaa aacaatctct gcgcctgtct caagggcgta caccatgtgt 694801 tggacataaa cctcgacaac atggctcttg ttggcctgct tcaattctgg tgtacctgta 694861 agttctccgt cttttccctg gttatatgcg ttttttctcc ccaaatcgtt ttgtcgctcg 694921 ggtaagactg aaatgctttt aaaagcacta ttactgttta ttatgctata tatatatata 694981 tatacagccc gagtctggct tgatcttatt tacatgatat atcatctaga aatctatata 695041 cactagatcc ctcatttgtt cttggtttga gtatagctga aacgcttcct ggtaggtgcg 695101 aactcgccca gtttgtggcc caccatatct tctgatattt caataggtac gtactcctta 695161 ccattgtgta tttgaaattt cagtcccacg aactgaggaa ggatggtggc ggcccttgcg 695221 tttgttctta ttggagtgcc cttagtcatg gcctccctta tgggtaatgg cacgatgttg 695281 gggcccttcc atacggaccg cgataaaagt ctagctgccg gttgcatttt atttttggtg 695341 gacactactt ctgccgatgc tgtactgctc ttgcaatgaa cctcaccgtt ttaagtcatg 695401 gttagattct tactaggcgc ttccaattgc catttcttgc tcagccataa ccgtgaatag 695461 tgatccaaac gctaatgccg ggtgatgctt aaaatttgaa aaattattgc agatttgtat 695521 tatatagaaa gcataactgg cgatgagatg tgctcgaaac tggacacctt taccattggt 695581 gaccggtagt gacaatgttt gcatcgagat ttgaccctag ccaattgact gctcctgcag 695641 ctagcgcacc agaaggaatc gtcggaacta ctcccccggc cattgtgcct ttaaagaggc 695701 aggctactga atctgataat gaagaatatg gctctcacca agattctgat gagagttcca 695761 actctagttc agaggaagac gaagaccgta tgcaagtaga ttatggggct agtgaagagg 695821 attcgagtga agtggaagag gaagagagta agccaagtac tcacagcaca gtgctatcga 695881 gattcaagca aacagtatca ttgcaagaaa ggctaggtgc atctgatatt gctgagagta 695941 aggaagacga aggtattgaa gacgaggcgg cctcaactca ccaactaaaa cagattcctc 696001 aacctgaatt cgtcaaaaac ccaatgaatt tgaatacaaa ttcattacag ttcaaatcta 696061 cgggttggtt aaatactgag aagatatatt atgataattc cttgatcaaa ccgttctcgg 696121 attacgcaaa tgaattagaa gcaaaactac tgcagaatat ttgcaagaat ttctctacaa 696181 acacttttcc catccaatcg atcatcctag actccatatt accggtattg aacttcacgt 696241 tgaacgtatc taagagaaac ttcaccagaa gaatcggtga tattcttgta aatgctgcta 696301 ccggttcagg taaaactttg gcttactcca ttcctattgt tcaaaccctc ttcaagagac 696361 aaattaacag actgcgttgt ataatcatcg tccccacaaa actattgata aaccaagttt 696421 atactacgtt gacaaagcta actcaaggga cgtcgcttat tgtgagcatt gccaaattag 696481 aaaattcttt gaaggacgaa cacaaaaaat tatcaaattt ggaaccagat atcttaatca 696541 ctacacctgg tagattagta gatcatctaa atatgaaatc gataaatttg aaaaacctaa 696601 agtttttgat tatcgatgag gctgatcgtc ttttgaacca gtccttccag ggctggtgtc 696661 caaaactaat gtcccatttg aaaacggata aattagatac acttccaggg aacgtgatca 696721 aaatgatctt cagtgcgaca ttgactacca acacagaaaa gttaaacggc ttgaaccttt 696781 acaaaccaaa gttgttcctg aagcaaaccg ataaattgta ccagctacct aacaaattga 696841 atgaatttaa catcaacatt cccacggcga aaagtgttta caagccattg atattgttgt 696901 attcaatatg ccaatttatg gcacattccc ccattgctgc aaagattttg attttcgtta 696961 aatcaaatga atcgtctatc agattaagca agttactaca acttatctgt gaatctcgct 697021 cacaatccag cgtattgaaa aaccttcaaa atttggcggt gagtattaat tctgtcaatt 697081 caaacaactc caaagcagaa aataaaaaaa ttgttgcgaa cttctcgcat cactcggaaa 697141 gcgcaggcat taccatctta attactaccg atatcatgtc ccgtggtatt gatattaacg 697201 atatcactca agtaataaac tatgacccac caatgtcttc tcaacaatat gtccatcgtg 697261 ttggtagaac agcaagagct aacgaacttg gttccgctta taacttacta gtaggtagag 697321 gtgaaagaac gtttttcgat gacttaaaca aagatctaga tagagacggt aaatctgtcc 697381 agccattaga actcgatttt accctattgg aatctgattc tgaactatat acttcgtctc 697441 tagaaagttt gaaaaactat cacaataaca ccgcacaagc ttaatttctc actttccacc 697501 ttcgcatcca ttcatttata acattcaaac attttttttt ttagtctcat tctaataact 697561 cctgagtata gtaatattaa tatgtatgta ttgatgggta tgtaactgta aaattatatt 697621 cggtctatgt ctattgtagt ttcacacgtt ggaatgctcg tttgaatgca cttgtcaatg 697681 gctaacctta acatcaattc gtcatcgtcg gagcctcctt tcattgttat cttgatcagt 697741 accacataaa gcgtaaaatt cactttgctt attactatat catcgtaatt taggatgtat 697801 ctggatttaa actcacttaa tctctcgatt tggtccttga tcatgttctt aatggttgtt 697861 ggattttcag tgaaacctgc agaattcaaa aacccagttt tccgtatctt tgtattcttt 697921 gttgctatag gtagtgagct cattgatctt ggtcgtacag atggtttttc tttagcagct 697981 ttagactcga cttgttgagt atgggcggtc gtatcagtgc tgtcattatt attgaataac 698041 gctgaattgg ataaagatgt ggtggaaaat cccattagta acactgtcga ggtccaccgt 698101 gctatagtca gcccatgcca tagaattaaa ctcgaaataa ccaaagtagc aaggtaatcg 698161 gatatactcg ataacagatc caatagtagg ggataaatga ataggtatgc tgtataagtg 698221 atggtaataa tcgggttctt cgtctttaaa ttactgtatt tgttagcata aaacgtctta 698281 taaagtgata acgtcgataa cactaaattg atcattagta tgctatacca taaggtaata 698341 ttctcgtttt gtgaatcatt ggcattggca atgtgggaat gaggaatttg ctcattaatt 698401 tcatcgtgat catggttatt cgtcaaagaa ctaccagatt ctacaaagag gactatgaat 698461 tcttcaatta tatggaataa aaggtccagc ccaacaaagc ataacgaaac ggcaagcgca 698521 aaacttagta gaacgtctat tctatttaac ccgaatggaa atgtgatagt gcctgtaaac 698581 catacctgga actgagacaa attttccaca aatatgatta ccagcgaacc gatgatatcg 698641 taagtaataa aatgcgatag tgtaataaaa ttactccatg agtacaggtg tccgacttgg 698701 aaagtaatca gacatgcaaa gatttgtaga gcggcaatag ataactgaat ataagccttt 698761 ggccatggca aatttgacag caaatcattg aaatctggaa tgggaagaga tttggcaatg 698821 ttcaaaggaa ttttcacctc aggctcttga aaaaaattca tggatacaga ggaatgctta 698881 taacgatgcc ccttacgaaa tgaggtcctt gatgcagctg aagagggtgg tgtctgttga 698941 tgcggttgca gcgttgatgt cgtaaaatta aagggagaat ccaaggtcat agaagacctc 699001 ttactgctgc cagcatcggg ggaaatgcct cttaccggtg atcttgttct gggaggaggc 699061 ggcaccagct ttggtgctgg tatatatttg agtgattgcc ttcgtccttc gttgcctttt 699121 cccttcatca aagcagcttc attgatatta gcattactag aagcgttttc accaaaagtg 699181 aacgaaggat tgtagatgat actagaactg gaattgttac cttccttggc agaataaaat 699241 agggaactgg gcctaggtga tgcaaaaaat gtcctgtttt gggatggtat accgtctaca 699301 ttcccgacag cgttcatatt ggacaaagaa aacgatgaag catcggaatc attcaattta 699361 ggagtctgga aagcaacttc cggagacaaa ttgtcctcct cttgtatagc gttcatttgc 699421 ggcgtctcca tagctctttc cctattctat aatctcgctc acaagtcact aaatattcac 699481 tttttctctc ttagtaacaa aaataccttc aaggttcatc attttcagta atgaatattc 699541 ttgatattac gcaataggac acttgtggaa aactttttga ggttgcgtta cccgcgctga 699601 aattcgagaa caataaagat catcatctct cattttagct acattataac ataagaaggt 699661 gcatttagtt atcttatgtg gactagggta tgacaaacat ggctgccaag aatcagttca 699721 aaggaagcag cttcacacta gcgcagctaa tcgaagaagt cggacgtaac ggaggaaaaa 699781 agcctgtgtt ccagtataag gtaccacggt cgatacgatg ggcttcaact gctctagctg 699841 tagtgtttct cacatatggc gctgcataca ctgatatgtc gtggagaact gctcgagaag 699901 tgtacggaaa cgctactgag gaagaaaaac acagcccgtg gttcaagtgc aaaacttttg 699961 ggcctgtggc tttaggggtt ttgcctgtga tcctcgctgc tgccacgaaa cacgtaacgt 700021 caagactagt cacagaaatg aaatatctgc caccgctcaa gaatagtacg gtgccacggt 700081 gtcaattgac tcgacgcact tacttgttag gaagaccagt ttctatcacg agggagatca 700141 atgaactgtc taaaaataag gccaccaaga tcttcacagg agtaggttct caaggtatgg 700201 aggataaggc cacctttgtt ttcttcacag tggatgaaaa agcaccctca tttttcaata 700261 aattttacat tttctcgaga tctggtagcg ttgtgaagaa tgacgccagg atcttggact 700321 gctttttcaa cagtgtggca gaaaataagc tattgaacag gtcaatatta actcagatcc 700381 tttcacatac gtctgccaag accctatttc actcggggaa ttctagatca tccatcaaga 700441 atatcgtgaa gcccaaatag gtacggacat ctacgtaaga atgcatgtaa ataataatcg 700501 aataaaagaa caattaaaca cttgtatatg cacgctatat ctacaagaat ccaaacagtc 700561 tcaagatgta gtcgactgcc aaggcgtacg taaagtaaag tccggtgttg atatttgcat 700621 taaaatactt ccagcagttt ttaggattgt caagatccac tttctttatc atgctgaaga 700681 gtctataagc gaagactcct agtccaccaa tgaacccagg cccccataac aacccactgt 700741 tcaagccggc gacagctaac agtgcgattt gagacgcgga catggccttc atgatagact 700801 ttgtgcgtgg accccaagcc aaagcggtag acttgattcc agccttgatg tcaaactttt 700861 tatcctggtg tgcgtatata gtatcgtaag tcatacacca caagtaactg ctcaggtaca 700921 aaggtatcat tgtaggccag ctcattacac ccatggcagg aaacccaagt aacgctcccc 700981 aattgaaaca tgcacttaat gcagcttgag gatagtacgt aaaccgctta aacaaagggt 701041 atgtgaacac aataggtaac gatgcaaggc ctagccacca acactgcgca ggaagcaaag 701101 atagaacgcc cattccaaca agagtttgag cccccaagaa tactaacgcc cgacgggggc 701161 tcactctacc agaggcgata ggcctctcga cggacctgat aactctttga tccaactttc 701221 tatccaaaaa atcgttgatg gtgcagccag cacctctcat taccaatgca cctacaccga 701281 aaatacccaa cataccagct gttgcgctca atgtagcacc ttgcatcatg gctcccataa 701341 gtatagacca actgcagggc aaatataaca gccacgtgcc cacgggtttc tctagcctca 701401 tcagctccgc atacggtatc catttcttag gcagccgaga cacgaacggt cccagtccat 701461 ccaatctttc ctttcttgca acttccaact ctttcgacgt aaacacaggt gctgattctt 701521 tcgaggaagg ggaggaggag gaggaggaag aagacgtata tctctttctg ctgcttccaa 701581 tgattccagc aacggtaact cggccgctgc ccagaatgga cctccctagt aaaatactct 701641 ttctctgcca aataaacatt agttgacact gttattctac gacagttatt tctactgtaa 701701 tctatagtat actccgccct tctgataacc ttacttttaa ttttggcctg attcttgtga 701761 aacttttcca cgatgccgaa atcgccgaaa tggctcgttt agccttttct cgaagattga 701821 tatataaaga gcatccatcg tgctggtaat ggtgatgcaa gattgaaaat tcccagacag 701881 tgagcaccag cacaatgacc gtttacacag catccgttac cgcacccgtc aacatcgcaa 701941 cccttaagta ttgggggaaa agggacacga agttgaatct gcccaccaat tcgtccatat 702001 cagtgacttt atcgcaagat gacctcagaa cgttgacctc tgcggctact gcacctgagt 702061 ttgaacgcga cactttgtgg ttaaatggag aaccacacag catcgacaat gaaagaactc 702121 aaaattgtct gcgcgaccta cgccaattaa gaaaggaaat ggaatcgaag gacgcctcat 702181 tgcccacatt atctcaatgg aaactccaca ttgtctccga aaataacttt cctacagcag 702241 ctggtttagc ttcctccgct gctggctttg ctgcattggt ctctgcaatt gctaagttat 702301 accaattacc acagtcaact tcagaaatat ctagaatagc aagaaagggg tctggttcag 702361 cttgtagatc gttgtttggc ggatacgtgg cctgggaaat gggaaaagct gaagatggtc 702421 atgattccat ggcagtacaa atcgcagaca gctctgactg gcctcagatg aaagcttgtg 702481 tcctagttgt cagcgatatt aaaaaggatg tgagttccac tcagggtatg caattgaccg 702541 tggcaacctc cgaactattt aaagaaagaa ttgaacatgt cgtaccaaag agatttgaag 702601 tcatgcgtaa agccattgtt gaaaaagatt tcgccacctt tgcaaaggaa acaatgatgg 702661 attccaactc tttccatgcc acatgtttgg actctttccc tccaatattc tacatgaatg 702721 acacttccaa gcgtatcatc agttggtgcc acaccattaa tcagttttac ggagaaacaa 702781 tcgttgcata cacgtttgat gcaggtccaa atgctgtgtt gtactactta gctgaaaatg 702841 agtcgaaact ctttgcattt atctataaat tgtttggctc tgttcctgga tgggacaaga 702901 aatttactac tgagcagctt gaggctttca accatcaatt tgaatcatct aactttactg 702961 cacgtgaatt ggatcttgag ttgcaaaagg atgttgccag agtgatttta actcaagtcg 703021 gttcaggccc acaagaaaca aacgaatctt tgattgacgc aaagactggt ctaccaaagg 703081 aataagatca attcgatatg taacattttt cttttctttt cttttccttt ttttacaata 703141 gctaatttac gtttccctac ggtattggtc ggaacgacca agcttcaatt tataaatatc 703201 ttaattttaa cagcagttac cacttgaatg agaaactttt tgatgcctac tcttttgctt 703261 tttcatatca tgacctccct acatgcttcg gaatttcctt attcgtagct gtctaacagc 703321 accacttagc acaagtacgt ccacccgttt catacttaaa gatctcagca gccacccaat 703381 ctacatttag ggtacctgtc acatatcttc tcaaatttta ggttagcttt caattgtaaa 703441 gtctcttttt ggatattgca cgtttcaagt caaaacgcgg ctgtaacata attttctgaa 703501 acaatattaa aacatagtaa tgacttaaaa caagcgacta tcgcaaataa gcagttccca 703561 gcaagcaatt aaaacgtata taagcgcaga ataatgatct atcatcaata attatcgtga 703621 acttttccag tatttacgtt catctttgaa aaacggcgag cattaacaat aaaagctaaa 703681 aaaaccaaaa aatttcagat gacattatct ttcgctcatt ttacctacct gttcacaata 703741 ttgttgggat taactaatat tgccttggca tctgatccag aaacgattct agtgacgata 703801 accaagacaa acgatgcaaa tggggttgtt acaactacag tttcacccgc gctagtctcc 703861 acatccacta tcgttcaagc tggcactacg acattgtata cgacttggtg tccattgacg 703921 gtatccactt catctgctgc cgaaataagt ccttcaatat cgtacgctac taccctatcc 703981 agatttagta ctttgacatt atctacagaa gtctgctccc atgaggcatg tccttcgtca 704041 tcgacgttgc caaccaccac cttatctgtg acttccaagt tcacttcata tatttgccct 704101 acttgtcaca caaccgctat cagctcatta tccgaagtag gaactacaac cgtggtatca 704161 tccagcgcca ttgaaccatc aagtgcctct ataatctcac ctgtcacctc tacactttcg 704221 agtacaacat cgtccaatcc aactactacc tccctaagtt cgacatctac atctccaagc 704281 tctacatcta catctccaag ctctacatct acctcatcaa gttcgacatc tacctcatca 704341 agttcgacat ctacctcatc aagttcgaca tctacatctc caagttcgac atccacatct 704401 tcaagtttga catccacatc ttcaagttct acatctacat cccaaagttc tacatctacc 704461 tcatcaagtt cgacatctac atctccaagc tctacatcta cctcatcaag ttcaacatct 704521 acatctccaa gttctaaatc tacttctgca agctccactt ccacttcttc atattcaaca 704581 tctacatccc caagtttgac ttcttcatct ccaactttgg cttccacttc tccaagttca 704641 acatctatta gctctacttt tactgattca acttcatccc ttggctcctc tatagcatct 704701 tcatcaacgt ctgtgtcatt atacagccca tccacacctg tttactccgt cccttcgact 704761 tcgtcaaatg ttgcaactcc ttctatgact tcttcaactg ttgaaacaac tgttagttca 704821 caaagttcgt ctgaatatat caccaaatcc tcaatttcta ctactatccc atcattttcc 704881 atgtctacat atttcaccac tgttagtgga gtcactacaa tgtatacgac atggtgtcct 704941 tatagctctg aatctgagac tagcacatta accagtatgc atgaaacggt tacaacagac 705001 gctacagtct gcactcacga gtcttgcatg ccctcgcaga caacaagttt gattacatct 705061 tctataaaaa tgtccactaa aaacgtcgca acttctgtaa gcacctcaac ggttgaatcc 705121 tcatatgcat gctccacatg tgctgaaacg tcacactcgt attcttccgt gcaaacagct 705181 tcatcaagtt ctgtaacaca gcagaccaca tccacaaaga gttgggtaag ttcaatgaca 705241 acttcggatg aagatttcaa taagcacgct accggtaagt atcatgtaac atcttcaggt 705301 acctcaacca tttcgactag tgtaagtgaa gccacgagta catcaagcat tgactcagaa 705361 tctcaagaac aatcatcaca cttattatcg acatcggtcc tttcatcctc ctccttgtct 705421 gctacattat cctctgacag tactattttg ctattcagtt ctgtatcatc actaagtgtc 705481 gaacagtcac cagttaccac acttcaaatt tcttcaacat cagagatttt acaacccact 705541 tcttccacag ctattgctac aatatctgcc tctacatcat cactttccgc aacatctatc 705601 tctacaccat ctacctctgt ggaatcgact attgaatctt catcattgac tccgacggta 705661 tcttctattt tcctctcatc atcatctgct ccctcttctc tacaaacatc tgttaccact 705721 acagaagttt ccactacttc aatctccata caataccaaa cttcatcaat ggtaacaatt 705781 agccaatata tgggcagtgg atcgcaaacg cgtttgccat taggaaagtt ggtcttcgcc 705841 atcatggcag ttgcttgcaa tgtaattttc agttaatatc agaacaattt aattcattta 705901 tataaacata tacaatcaat cgaataaaaa tacaacaatg taatgaaaac gctctctatt 705961 gatatgtatt tgctgacgct tataaattta ttaaagtttt attttaaacc gttctagtga 706021 cttcacgcgg ggagatacat ccaatagtaa attacaaaat aaggaaagta taaaacaaac 706081 ggataacaac agtagcttgg agacagcaaa ggcacccgag caggcgtgga aacacacgat 706141 gcatttgaaa aaggggaaga ggagtattag cacagtatgg cgacttttat ggaagcgttt 706201 ttattccgta aactctaaga cgaatatgca tttttctcga agtaggaaga aaccagtgac 706261 aaacttcaca aggacaaacg gacttctcct gagctgtaat ggtgatacat tcccatatct 706321 gcgtacactg tggagatact tcaatgcgcc tggtaatttg atgtttgtca caactaatat 706381 tgtcgcattt atgggcattg ttacgtataa tacgctggtt actatcagca gtgaaagagc 706441 attcgaagag cagatgatgg cggcacaggt gagcctggcg aaacagagag aagagctcga 706501 gactacggcc ctcagcttgc cacgagatat tgaattgagg ggtgaagaag atgatattaa 706561 atgggagcaa cctgatgtag cacatgtccg ggaagatccc ttagtcgagg agcagaacgc 706621 aaagttagac acccctataa aacagtatac tttaggagat ttgattttga ataagaggga 706681 aaatgtcact gattatgact cgcagcgtgc gaaggcatct atattccaca tgctatatgc 706741 ttatatgctg tatcgagatg ttattcaacc cacgaccatg actcaaaata acaacagcga 706801 ggaatggcgg cgtgaagtcg agcttttgac taagggaaaa gaggtacaag gtactcatcg 706861 aaggatagac gtgttctacg acctgtggaa taaaaatttc gataagatag tgacatcacc 706921 tgagaaagtg cagaattttc aactgccgaa ctggtctaaa tacccaacga tattgaaatt 706981 catctgcaca gaacttcacg acaacagttt gaagaccttg ggtgagttta agcaattcta 707041 tggaaaggtg cgatctaacg aggtaaaaaa actgttgggt ctttggctgt acgaccattc 707101 cttccttttc ccccataata tctacgacaa cagaaccgaa gaagattttt acgatatatt 707161 aattaatgac tccatgcagg ataacaggat attccagaaa tactcttcaa ttgtaatgaa 707221 tccctacaac gaacgtactc aacttttttt ccctaatgta aattctccat ctgtcaacaa 707281 gccagtaccg agcatatctc tggaaacata cacacgacta ctcaagggat atatcaactt 707341 gcaagaaaca ggctgcaaat acgactataa tgacaatata ttcaaactaa tcagcatcct 707401 caaactaaat tgtttcctac aacgcaacaa gaagaaacac gcagggccaa ccgtcagaat 707461 cctactgccg agagatgaag accgctctca aatacttggt accatttcgc aggcagagaa 707521 gagaacctgt tatcaaattc taagcaaaaa tagggacgtg gttgcgctgc tgaaacgcat 707581 ttctgatatc caggcggact cttcttaata aaacatgtaa atatgtacct cccaaatcac 707641 actcatcatc tcatacgaaa ctgtatcttt ttgggtaaaa ttttcatcga tgagctttaa 707701 aagcaaaact acttcaccag caatgaagct actgtagcat cctatgatct cttcggctct 707761 acacatcata ttactagcct agtcaacatg aagttcttaa ccaccaactt cctaaagtgc 707821 tccgttaaag cctgtgacac cagcaacgac aacttccccc tacagtacga cggcagcaaa 707881 tgccaattgg tacaggatga atctatcgag ttcaatccag aattccttct gaacatagtc 707941 gaccgcgtag actggcctgc agtgctcacg gttgctgccg aattgggaaa caacgcctta 708001 cctcctacca aaccatcctt cccatcttcg atccaggagc tcaccgatga cgacatggcc 708061 atccttaatg acttgcatac tttactgcta cagacgtcca ttgccgaagg tgaaatgaag 708121 tgtaggaact gcggacatat ctattacatc aagaacggca ttccaaactt gctgttacct 708181 ccacacctgg tataaatcaa gcgagatctc tgtgtgtggg cacgcaagac gaaaagacaa 708241 ctatatacac agctatatat gtagtagtag cctcatatac gtatggcatc aaacatgtag 708301 cataaacaac ctaaaaggaa aacaaagact gagatctaac ccaccacagt ttctatttga 708361 gccttcccgt cgcgcgtgat ttggagatac agattctaag agctttaaag aacgagatac 708421 tctcctgttt taaggactca ccggcatata aggcagcaaa gtcgccggtt tgaaggttca 708481 ggggccttga aggtagtatc atttggaaaa cagcaagaga atatggctgg acaccatcac 708541 gaacatgaac aagagcgcga ccacgagcaa gaacacgaac acgattccct tcaacggcct 708601 actactggat cagaaaggac tagaagtata tccttttcga agttgcttac gcggtcatgg 708661 aaaaggaatg cgagttcatc gaacaacatg agtgtgtcta gcgtgaatct gtattcggat 708721 ccagagaact cgagagaatc agatcacaat aatagtggct cagagggcca gtcttcacga 708781 ttttctaaat tgaaaagtat gttccaatcc ggcaatagca gcaaaaatgc cagtgcccat 708841 aacagcagcc aaagcagtct tgaaggtgac tcggcgtcat cttcatctaa gttaagatac 708901 gttaaaccaa tgacttctgt tgccaatgct tctccggcat ctccaccact ttctcccacg 708961 atcccggaaa cggatgttct tcaaacacca aagatggtac atatagatca acatgaacat 709021 gagcgtgaac actcgaattg cgggtctcca ataatgcttt catcatcctc tttcagtcct 709081 actgttgcca ggactgggac gggtaggaga agatcaccgt ctactccgat aatgcccagt 709141 cagaactcga ataactctag tagcacctct gctatcagac caaataatta tcgtcaccat 709201 tcaggatctc aggggttttc ttccaacaat ccattcagag aaagggcagg tacggtacgc 709261 agtagtaacc catattttgc ataccaaggt ctaccaactc atgccatgtc ttctcacgac 709321 ctcgatgaag gattccaacc atatgcaaat ggcagcggca ttcacttttt gtccaccccc 709381 acctcgaaga caaattcttt gacaaacacc aaaaatttaa gtaatttatc actaaacgag 709441 attaaggaaa atgaagaagt gcaagaattc aataacgagg atttcttctt tcacgatatt 709501 ccgaaagatt tatcgctcaa agatacgctg aatggctcac ccagtagagg tagttccaag 709561 agccccacga ttactcaaac gttcccttca atcattgtcg gatttgacaa tgagtacgag 709621 gaagataaca acaatgataa acatgatgaa aaggaagaac aacaaacgac aaccgacaat 709681 aaaacgagaa atctttcacc taccaaacaa aatggtaaag ctacccatcc aaggataaaa 709741 atacctttaa gaagagcagc ttcagaacca aacgggttgc aactcgcatc tgccacatcg 709801 ccgacatctt cttcagcaag gaaaacatca gggtccagta atataaacga caaaatccca 709861 ggccaatcag tgcctcctcc aaactcattt ttccctcaag aaccctctcc aaagatttct 709921 gattttccag aacctaggag gtcccgacgt ttgagaacta aatctttcag caataaattt 709981 caagatatca tggtgggacc acagtctttt gagaaaataa gattgctggg ccaaggtgat 710041 gtaggtaaag ttttcttagt aagagagaaa aagacgaata gagtgtatgc tttgaaagtc 710101 ttgagtaaag acgaaatgat aaaaagaaat aaaatcaaac gtgttctgac agaacaagag 710161 attcttgcca ccagcaatca tcccttcatc gtcacactat accattcgtt ccaatctgaa 710221 gactatttgt atctctgtat ggaatactgt atgggcgggg agtttttcag agctttacaa 710281 acaaggaaaa ccaaatgtat atgtgaagac gatgccaggt tttatgccag tgaagtgaca 710341 gcagcactag aatatttaca tctgttgggt tttatctata gagatttaaa accagagaat 710401 attttgctgc atcaatcagg ccatatcatg ctttctgact tcgacttgtc tattcaggct 710461 aaagattcca aggttcctgt tgtcaagggt tccgctcaat caacccttgt tgataccaaa 710521 atatgctcag atgggtttag aaccaattcc tttgtcggaa ctgaagaata tattgcccct 710581 gaagtcataa gaggtaatgg ccacaccgct gcggtcgatt ggtggacgct agggattttg 710641 atctatgaaa tgttatttgg tttcactcca ttcaaaggcg ataacacaaa tgaaactttt 710701 acgaatattt tgaaaaatga ggtcagtttt cccaataaca atgaaatctc cagaacttgt 710761 aaggatttga tcaaaaaatt actgacaaaa aatgaatcta aaagactggg ttgcaaaatg 710821 ggcgctgccg acgtgaagaa acaccccttt ttcaagaaag tccaatggtc tttgctgaga 710881 aatcaagaac cgcctctgat accagtgtta tctgaggatg gatatgattt tgctaaatta 710941 tcatctaata agaagagaca gactagtcaa gacagccata aacatctcga tgagcaagag 711001 aaaaatatgt ttgaagaacg agttgaatac gacgatgaag tctctgaaga tgatccattc 711061 catgacttca attcaatgag tttgatggaa caggataaca attcaatgat ttatggtaat 711121 accaattctt atgggaaaat tgcatacact ccaaactcca acagatcgag gagtaatagt 711181 catcgaacct tttttaagag ataaaggggg ctttgacgta taagtgtcgg tatttttttt 711241 ttttttattg attttttttt cactcttatt ttttccctca tttattcatc atacatttaa 711301 cgaactctat ttcttttcaa aatccttatc tacctatttt tttttcttta ttttctttcc 711361 tctgtcagtt agtcagtagt gtgtaactta aataaatcat atatcggtgt ttcaatttct 711421 agcattctgt gtaaacatca gatgaagcat tgcctttctt ttcaatgaac tctatgtagt 711481 tttttcgatt tgcttgcgta ctatttttca cgcgatagtt gaagaaacga tagaaggatg 711541 gcgcaatata caagttaaaa gcaaatagat atctaatcaa tagttaacat ctagaataaa 711601 gtgctggaac ttagattttt ttgtgcaata tgggactgat attaaggtgg aaagagaaaa 711661 aacagttgtc tagtaagcaa aatgctcaaa aatccaggaa accggcaaac acatcgttta 711721 gacaacagcg cctcaaagcc tggcagccca tcttgtcgcc acagagcgta ctgccgttgc 711781 ttattttgat ggcatgcgtc ttcgcaccca ttggtatagg gctggtggtc agcacgataa 711841 gtgtccaaag actagtggta aactacacag aatgtgatgc attggcaccg gcgaagcatt 711901 ttgaaacgat tccctccgag tacgtggact accacttcag taagaaagtc gcagtccaac 711961 ctcaatggat ggtacttacg gatcctgaat taggcaatca aacttgtcga atacagttcg 712021 aagttccaaa tcatatcaag aaatctactt atgtttatta ccgcctaaca aatttcaatc 712081 aaaactatag agaatatgtg caatctcttg acctagacca attaaaagga aaagcattga 712141 tcggaaatga tctggatcca aactgtgacc ctttaaggac ggtagaaaat aagaccatat 712201 tcccctgtgg attgatagca aattcgatgt tcaatgatac attcggcaca acacttactg 712261 gtgtaaacga tactgcagat tatttgctta ccacaaaagg tattgcgtgg gacaccgaca 712321 gccacagata tggaaagacc gaatacaatg catccgatat cgtaccgccc ccaaattggg 712381 ccaagttatt tcccaatggc tacactgacg ataacattcc agacctacaa aactgggaac 712441 agttcaaaat atggatgaga actgctgcat tgcccaactt ctataagcta gcaatgaaaa 712501 atgagaccaa tgggttaggt aagggtattt acattgctga tatagaactc aactacccag 712561 taagatcttt ctatggaaca aaatcttttg tattaaccac aaacagtatt atcggtgctg 712621 gaaacgaggc attagggatt gtttatttga ttgttgccgg gattgcaact cttttcgcca 712681 tactattcct gataaaagtc atcttcaaac caagacctat gcatgatcat agctacctaa 712741 attttgagaa cagcgatacc ccattcgatg agagtagtgt cgttagtatt ccattgagag 712801 aaattttatg attgattatc atttactata aaatccctgc gtttgattcg gtctctaggg 712861 aagcgttgta atttcatgta tattcaaaat aaggacgagg ttatatacca tactatatta 712921 tctccttgca ttctgtatca aacactttat tcagtacata tacgatacct atatattcat 712981 taaatgttct tttcgcttta tttcagcaag gtatagtgct atttaaaatc cataatcgtt 713041 attgcgtctc tttagtctgt ccttcattgc cattactcca ctacttgcgt ctggtggcgg 713101 cgttggcgtg ctggaggtgt tgaaactgtt cgacgtttta cttcgaccga gacttgccct 713161 gaattcttgg cctgctgaag gtctagtcgg ccgtgatgaa gctcttctcg gtgtcgcgct 713221 agaggagctt gtatgattat tgtatatatc ttgaaacgat ttactcgcag gcgtgtactc 713281 cggtgtgttc ccgtttgaag aaggtgtacc cataggatct tctgaagaag ccttccttct 713341 gttagaaaag gatggcgaga aatgacgcga gttttgcttc ttcatatcat gcttcacttg 713401 agtatctaat attttacgtt cgttcggtaa atcttccttc tcccccaacc atcctgggaa 713461 cccctggaaa ggatgctgat tttcatagaa tttcacaagc cctttatgga ccaatgtagt 713521 atttacagta tcaccatctt tttctgcttt aatggataaa tgtgccaacg atgtagataa 713581 cgatttggtt gacgacttaa acttgttcca aaatcgcccg gatccttctt gggaatgcga 713641 tacttgactc atcatatgcg tgaaatctta gttatactgg tagttggtat tagggcctag 713701 cgtctaatag ttagttggcg ttttattttt ttgcaccttt cctaatagta ttaatctcta 713761 aaagtgaaaa actcctaaga gtctttacga gctcatttaa tacgttctga tcagaagcaa 713821 gactataaaa tgcaatagcc aatacttttt agactaaagg tagacgactt actagcggtt 713881 caagcttcag gaactacact ctcaattacg ttctagtcca ttttgtccct ctttccggtt 713941 tttttttttt tacgtttcct tatgaaagta taagtaatac taaagaaaga tttataaagt 714001 gccgttactg ttacgtatga taaacctttt gatacatttc ttcttattta agccactgtc 714061 ttttccttta gatagatgcc gtacttgtcc tttagttctt tcatgattgg atcattaatc 714121 tctggtgagt atggcgctag taagcctggt cccttgattg taccatctaa gacgaatttc 714181 gttgcaatgg caactggata accaacagta gcggccatag aactgtaacc accaacctta 714241 ccatagtcaa ctaaagtgga tgttcttgtt tcggtagttc catcagccca ttcaataccg 714301 aatttgtgtt gtagtacaac catatctctt tcattgtctt catattgcat tagttcttct 714361 aaacgtgcac atagagtgtc taaagcatta cctcttggtg tgatctttgc gtcagagaac 714421 aagcctaacc aagcaaaccc ggaaaggatt ctttctctat cttcatcatc tttccaagta 714481 gcctttgagt caatggaagc aatcaaatct tctttagaag tagacttggc acctaaatat 714541 tgttttagtg cttcgttcca ggcaattggc ttgctgaaga tttcgttagc atcatccttc 714601 aacataccca tgtcaactaa agccttaaca aattctggga aaccttgata tctcaaagta 714661 cctctaatga ccgtttcggc ttctggaata tgataaagat ccttgaaaag ggtagagtct 714721 ctatttgggt agcaaacgaa tgcataacct gggtagatga agtaaggctt agcagtggcc 714781 attaagtctt cggaagaaac agtttcaatc tttccgtctt tccagtattt agcagagttt 714841 cttaaagcca gtagcacacc tctggaggac catgaaaatt tgtatcctaa tggattatca 714901 gagtcttcag gagctggtaa accaccacag tatgacaaga atgactttag cttaccacca 714961 gctctgtgaa cttcatcaat agtcttgacc gcatacaagt ggtcgatacc tggatccaac 715021 ccaatttcgt tcataactgt aatacctgcc tttacgattt ctggttccaa ttctcttaag 715081 gcaggtgaga tgtaagagga agtgacgaca tcggtctttg ttctgatggc gctctttacc 715141 acatttggat ggaaggtgta tggaatcaaa gagatgacaa catcgttatc agccagaact 715201 ttgtctaagg cactgtcatc ggtaacatcc aatgaaatag ccttggatcc agagggcttg 715261 gccaatgctt gcgcattggc taatgttcta catgcgacag tgacattgat gtcatcatta 715321 gcagccaatg tgtcgataac aggttgtgca acaaaaccag atcctagcaa caaaacgttc 715381 tttcccatat taaaatatat aatacgttaa tataactcaa ttgtcctgat aagttttccc 715441 tactgcctaa ggatccttcc catgtaattt taccaggacc ctacggttta tataccatta 715501 agccaaattc tgtgctactt tctatcatct attgctgata attccattgg aaattctcaa 715561 taccctttat tgacatcttt atttttcact acaaagcgaa tttttccaac ggaatttcga 715621 ttccagagta tgagtaattc ttttcactac taaacgcatt gcttcgtggt cagtagtaac 715681 cgcaatcaca ctcttcactt ctgttgtggt gaatatcaaa agaaacaaga gatcatccac 715741 aatttcctca gcttgacttg tctgcagttg cgattaaaat ttgacttttg ctccaccgct 715801 ctctacaggt attatatttg gaaatcatca aatgatggga atcccctacg tggcacttag 715861 atacgataca taagactctt gcatatgtag ctaccaacgt gggaaaacct ttcaagtaac 715921 agtttgtttg ctcttagcaa cttctagccc taatgaaaaa aaatgaaaaa taattgccag 715981 cttttccccg cgacttttca aaatcggtat aaaagcaagt cgaaaatcag tcaaaaaact 716041 tttctctctt gattgcttat tgcaatctca cttgtttttt ccttgatttt actttcaatt 716101 tagtttacaa tatcatggga ctttatctcc atgactatgc catttctagg tagcctatgg 716161 taaacgaatc ccgtagatta ttcacacgtt tgttgtcttt gttgacaaca acacagagta 716221 agaaaaagca aaagatttat ctcttttgtc catctttttt ttattttgaa ggcgtgtaac 716281 atttattggt tacaacatgg cttgttttct tgtccctaac aatcgccagg agaatttttt 716341 ttgaaaattt tcttctattt taattatgta cataaatgtc gtcagttaac tacaaatgag 716401 ctatctatca atatgctttt tttttttttt aattactgct caagcttgct atccccttct 716461 acctccgttt cctagcacag aagaaagtgc ccatatatca ttatattcaa tttttaactt 716521 gtctcttttt cttttctgcc tcggtttcgc gcatctactc tacgctatat tttcataatc 716581 atctcattta aatggcattc attcccttcc gcgccagtat attagttact aatcatacag 716641 tttcttgttt caatttttta gattttaatt agcggttttt ttttggtttt tcttaagatt 716701 ggttttatga tttttttttt tctttttcaa atttttttat tattttttca atttttcttt 716761 ttaaaaggct tgtggttgac tagtcctttc tttttagggg ttgctttcta tgagaacgtg 716821 ttccattagt aaatatgcca ggaggattat tgctcgtggg cttctttact gtttttcttt 716881 ctaagcatac ttcaatacca tcaattgact ttttcttctt ctctaaagca tcgatttggc 716941 tcttttgagt ttcaaagtcg acgacggcaa aattgtctgc agctgttatc ctcataactt 717001 taccgaattc tttttctaag gcacttctca atttttcttc tcttaagcca tttgtacctc 717061 taatgtagat tggataaaag ccgtccttgt taacggtgct gaatactggt tttttcttat 717121 ttttgctgtt agcactagcg ttgtccctcc gattccccat ttcaaatttt ctttcagtcg 717181 gtttcttggg tagtgtttca ggtctgatgt attcaaccgt ggtattattt ttgctaattc 717241 tgtcggagtt ttcattcatc aactttgagg cccatgtcat ctttggtgga ttcgcaacgg 717301 gctctggaga agatgaaggt gttgaagcgt tattgccgga ttctttggcg tcggaaacct 717361 gtggctctat tggtttaatt tcagtttcag cttcctttac gcccccaggt accggttttt 717421 catcactaac ttctttaccg ttgggcaaag aagagttatt aacagcattt atggcctcaa 717481 cagagccttc ctttgtcttg attggtgcag ctttcttttc ggctttgtga gatttttcat 717541 ttagtttagt aacgtttcct aactcttctg tagagacctc atcttgtttg tggttgccct 717601 tagtactaga tggtaccgtt tcggtgtgaa tcttggactc tttagtgacg ggtatagccc 717661 gaggttgact atgatcgaca attggttttt cctgagttga cgattcagtt ggcgcagttg 717721 tgtctttgac cgtttccttt ttggcctttg gtttcgatat ttctggtgat ttttcttttt 717781 ctttttcttt ttcaactccg gactcatgcc ttattttatc ttcttcaact gcactgacag 717841 agttctcctc gttagattgt gacaaagaag catctgttaa gacataaggc ttgaatgaat 717901 tggaaataaa tctgattata tcattggtaa tgtcaaacgt agacccattg ctggatggta 717961 gcaggataaa tgtttgacaa aacttataga ccggagttcc tgtccaaaac atttcacccg 718021 tggccatgat cagaatgctt ttgtgcaagt gcccagtgta ctggaaatct atagtatcta 718081 attttagttt caagctccta actttggcat catttctaga aaaaaactta ttaatgtttt 718141 cacgtccagt aactttcacc gttggaagaa cgtcatcttt ttcgtttgtt gacttggact 718201 gataattagt atgcgtcaac tcggctgtac ttgcataaaa atatgccaat ttggaagggt 718261 cggtcctcat tctttcgtag tagttttgca aaaaggcaaa acatatgtct tgaacggtaa 718321 cacccatttt cttttatttg atacttctat tcgagggtat gacttcaaat gcaactatta 718381 gtgacaaggt aataaaacta taacacactt gaaaaaaaaa atgcgatggt tttgtagtat 718441 tcttcgtgat ctttttctct ttaaaaatca acgaaaaata aagatgtatc agtaaaataa 718501 gttttcaaca gattctctgt aaaatgattg actaattgaa tatttgaaag aaaatgaggt 718561 ttgaacgaaa ataataaaac aaaaaaaaaa atgtaattaa atgggcaaaa atgaattaaa 718621 atgtagggaa aaaacacaac ttgaagaatt aaacagagta aaaaaacgaa agcttgtggt 718681 aggtgatata aataaattaa agcaatatct tactgtttat tcttcctcta gaatagtttt 718741 ggtactaacg gtaactagaa aactgaagaa gtttttcgta ttcttctaat actcaagcaa 718801 aatatcctat gtcaagtact accacttgta cagtcttcgt tttgtacaaa ttaggtatga 718861 attgctcttt tttgaaacag taatgggata aaaaacaaat gacttagttt aacgtccgcc 718921 ggttgcgata gaacttttaa ccgtaacaat agtaacagtg gacaggaaaa aaaaacggta 718981 cgaaaaggta atattgccta atctgaaata atgtagtcac tctagaacta ttaataaaga 719041 agcttgtact tcctcttatc cctggaatgg acggttatgc tgcttgcaat atgtcattct 719101 ttcattaatc gccacctgat gtttttcgct gctttggacg aaaaaatttc caagaaaaaa 719161 taaatggtta aacaaactac agcgcacgtg accgataact atacgggaat aacgcatcaa 719221 tctcctgtgg aagagtgctt attgcatcga agaaccaatc tgtattacta catgtccaat 719281 cataagctga tgttgctttt aaactttttt ttttaaaatt gtgtatacat atagtacata 719341 aatgatcatt ggtccccatc aataccgtat atgacacctt ggtacttggc gaaatccgta 719401 ccgtttggga acttatgcat agacagcttg ctcaattggc agaaggatag aagcatcaat 719461 agactctggc cgcctgtagt agtaaatata gagaatcttg gtagccctaa ctcatcggca 719521 agtgtggtta gtgaatattg ctgctgctgt tgctgttgtg aagattgttg caattgaggg 719581 ttcttgaact cctggattat tttatacacc aggtttaagt cgtagaaatt gggcatgtat 719641 tgatggaccc accactcgaa atcctccttg ttgttgggca tggagtcatt cattagaatg 719701 ttgatcagga aacctagatc atatgccgca tggtatgtga tccaagtaac agaatcatcc 719761 atcattaaac cagagtccat tagaagctgc gaaaattcaa atacatcgat gcctaaattt 719821 tcgtgttttt cgaagttgat acctgatttt ctgagtaatt ctaacgattc tgtggacatg 719881 atttccttct ttgggtcaaa ttcaaaattg aactgccacg ttgagggacc gttgtcaggc 719941 ttattgccgt tggcgtcact caaggaaaga ccaagttgta ttgggtttaa gaagtctacg 720001 ttggccctca ttgtctgata gtggtaatcg accttcgacc tgaaagtgcc gatcggccta 720061 gccaaagtcc ccacaaactc agtactgatt gacacatgat tatactgcga gaccagttgt 720121 cttataacgg cgaattcact gtaaaggttg gacttccaga catcgcgaac gaaaagataa 720181 tttgggggtg gtaaaaagat cggtggcata ctttggttgg ttaaatgctt gggtagctgg 720241 gaagccaagg gacgattgag tcccactccc tgctgctgtt gctgctgttg ttgttgctgc 720301 tgttgttgtt gctgcagaac gttcagtccg ggcggcaaac tagccaccga aacaggcgtt 720361 cctatattaa atggctgctg ttgttgttgc tgttgctgtt gttgctgagt taacagtggc 720421 tcgttcttct gcttcaaaag ataggcattg ttcatctcct gattaacaga gccattaatt 720481 gtatttacag gcatcccttg aggaaacatt cttgctctat taacctttgg cgaatacacc 720541 tgaggtccca tgttttgctg ctggtgttgt tcagaagcct gcctctgaga gaaaaactgc 720601 tcacctccta cagctaatac cctcggttgt acattcatag attgcataat cctttttgac 720661 cctttataaa tgtataaaat tgagttgcct gtttctaatc gttcgaagta tttccagtat 720721 gaaaaacaag gaagccctga taacgagaca cgctaataaa cttcaaactg atctttcttg 720781 tcagttatca ttctactact ataattgaaa agactcaata aagaaaatat cataatgatg 720841 aaaaaagagc gagcagcggg taaggaccga attccgtttg gaatgactgg tataatgaga 720901 tttaccttat actatagaga gggctatatc attaccgaac ttaagttttc tattggaata 720961 ttatacttta taaactaaat aattacccat ctatgttgtt tccccaagaa tgtttgctgc 721021 catataataa gaacaaaaaa aaaaataaca aaaaaaaaga aaaaaaaaat cacttgtaat 721081 cttaaattaa tattatacac cggttgtccg tttttacctc tatgccgtct tctcaacttc 721141 tttcttcttt ggtttttctt ccccttcctt ttcaggtgga aggacgaacc aagggatttt 721201 acctctatta aaatcattca atatttgctt agaaacacca gactcatcag gctcaccacc 721261 cttcagtaat ctaccttgtt tccttgccag aatttcaata aactccgtgg catccttcca 721321 tcctgagatc tcgtaagttc tttccaagtg ctttacctga caacgtttta aaacacctgg 721381 aatatattgt tctgggtgtg tgacgtgttc gactctgaca acacctctga ataaaatgtc 721441 ttcttcggag tctttactag aaggcggcac aatacctgga caatcaatca aaaaaattct 721501 tttcataaga gtaatatatt gccagacctt agtttcacca gggattggtg caacttgaca 721561 cacctttttc tttctcaatg tgttaatgat ggacgattta ccagtgtttg gatagccgat 721621 aaaccctaca gatatttgct ttctatcagt atgcaactgt gagaactgac gtagcaactg 721681 aattaacgaa cctttaccga aagagttggt aatagatgcg tgaaacgcca aagttggacg 721741 ttcctttgac aaatgtttga cccaagctgc ctacttgtaa agttagaatt gaaaaaaaaa 721801 aaccttctgt tagtaaaaaa tacattttgt ttcataatag gtaatctttt gccccaagag 721861 aatgtaataa tcattgttat agccgagatt gattgtttcg aagagtggat taaactaaaa 721921 aaaaaaaaaa agtagaaaat tgtgaggatc tttactacga acatattgta tggagcccga 721981 gataaagtct caaataacaa aagctcaact cataagatcc tcgctgttct aaaaagcgaa 722041 ggtatacctt taaaacaaag gttgtccttc taatttaccc atgaggcttc cccagaacgg 722101 ggaaatatgg ataagcgaac agtattactc ttccaaaaca gtaacagaca cttctgtaga 722161 taagtttatc ctaaaacgga tagagaagca ccctgacaaa aaggtttggt aataaaaatc 722221 atactctatc gaaaaaaaaa atctctcgtg ctatcctctt ggttggaaag aatcaaaaaa 722281 aaaaaaaaaa aagttaacat actgcaaccc aggtaggtac caaatcacac ttattaagaa 722341 cataaattaa atgcttgtgt ggtgtttcct tcttcatata ctcttccacg gacttacaac 722401 gggtacccaa tggatccctt gcatctagaa catgtattac cacgtcagac gaatcgatga 722461 ctttatataa ttcgttccaa atacgtttgg attgaccctt actgaaaata gcttcttttg 722521 ctgcggaggt ccacccattt tctttgtctt cctggttccc cattagtcct aatgtggcat 722581 ctaagacttg cttttcctca tacttggtaa tgtcttcatt tgtagccttg accaagtcct 722641 ctagattgga tgcagcaaga cgtggtctct ttctttgggc tttgggccca aacgcatcag 722701 cataactttc ggtatccaaa attctggctt ttggggattc atctgcgtcc ttttcttcca 722761 acaatgacat gggaagctta tttcttctca gaagaacttg atatgtatct ttttgggttt 722821 cacccaatgc acttctgaaa tgctgcagtg cgtcctgaga tatcactctt gtgttaccga 722881 accaacgacg atctggttgg accctcgcat ccggtattgt ggagtcctgg aaagaagcgg 722941 ccctaattaa attacctttc ttattcctga tctccttccc actagtgtac atattcagga 723001 atttgactct cttggagtct ctgtagaaat tttcaccctt cacacgaaga ttaccatctt 723061 tggtgtcacc ttcacgaata cgtctagatt tctctttctt accagtaccc attgtattat 723121 tcctcccctg atatttagtg gttttgctgc aagtcaacag atcttcaaag ttaacactta 723181 agggaaagta ctaacaagta gtaaatatct tttatatatt ctacgcttct ttatatgccc 723241 aaaaagaaga aaagtgaaaa atttttcttc aagcgaaaaa tttttgcgat gagcatcggg 723301 caaaaaaacg tgctaaatga caggttgtgt ttatatattt gttattgatt ctatattata 723361 gtaaattggt gagaacatta cccaagtctt tggacccaga ggattgctgc ttgatatcag 723421 agggagcatt ggcacggctt gtttccacac gacgttgttt aaattccctg tgagggtgag 723481 aatctgcaga ctctccttct tttccggcgc gcttcctaga gttcttaatg ttttgtatca 723541 tcttactttg ctccacgttt ctaatgaatt ccgcgttcag tttgttggcc tgcgagattt 723601 ccatctccaa cttggcctgt ctgatatcgt tctcgcgggc aatctgttca gtcaaatctg 723661 cccatttgaa acctgggagg tacttcacgt tcaggatatc atcatggtag aaagtacctt 723721 tcttgccacc aataatgttc ccgttcaacg tctccgcaca caatttggcg tctcttttcc 723781 taataaactc ggcccaacct tcttcatact tgtttttctt gtttcctcca cctttaactc 723841 tttgcttgta cttttgatcg tcctctttct ttagaaatag tctatctacc tcaccaaaac 723901 gagttaatat ttgtctcatt tttgcaggtt tcatgtaagg tggaatactg gagaagtata 723961 ccaccccagt cttgtgttta gacttcttgg cggcctttga ttttaccagt tgccttagtt 724021 tttctgtttt taaatccagt gaagtggtgg acgaagcttg ttcttctact tctcgatcga 724081 gcttttctcc attctcttta tctggttgtt ctacatcctc tttttcttct tgtttttgct 724141 cttcttctat gtctgactcg ttttcacttt cgatgtcttc taccttctta ctgaagatat 724201 catccttact agaaattttt ttcttggtct gaattaagac gttatgttga tcggtttcct 724261 catctgagga aaagtcttca aagtcactat ttactttttc actcatgcgt aaaaatttac 724321 ttcactctgc tgcagtaaac tgtttgcttt gtacttacat agcaatgggt agtttgtcag 724381 gttgaaattt ttcaaaatct taatagcgaa agttttactg cgcaatgtga gaaaagctgg 724441 ctataacgaa gtaattcaaa ataataaaac aagagaaaga aaaaatttac acgtcattgc 724501 ctttggaaat gtgatcagac agacccaata tcaccgttta aatattcttc acgagataat 724561 gtagtttgtc aattgaaacg ctatttggtg gctggctaat caaatatggt cgatgaaggg 724621 gttgtcaatc cagcagccct taaagaattg tcgctatctg tttgttccta taattaattt 724681 gcactgaaaa gatacatgtg cattattgca gtatattata aggaattccg gagttttcta 724741 gtaactttct agtcgcgcaa ccgagagatg agtactacaa cgcaacctat ttggtagtgc 724801 atcctacaca ttgtgaacgt ttttggttca tattacaata ttacgatatt acgaatttta 724861 ccctttcttt aatactaact ttgatcagaa agcaccttta tcaatatggc cacgtctggg 724921 aagtcggtca taatcaaaag gctacaggct ttggggtttg aaatatcaat atacgaattg 724981 tgagactttg ttttatctta gggacgaaaa tggatgtgtg aaattactta tggaaggatc 725041 aataatagca acgtttgcta atgtgttaag atggcaaaat gctactggta cgcctcgttg 725101 agtatccatc attattaata gcgccaaaat tgaaacatta attgcggttt tagaacaact 725161 ttagaattac agagcaaggt gataagatct caatagctta tgaaaaataa taatttttta 725221 gaacctaatg aacgtgtcga aactttccgc aaaatattat gtacatctct actcaacctt 725281 ctattaggat catgagaaat gtgttaaaac agaaaaaatg caccctcata ataaaaaact 725341 tggccaaacc aaaccctttc tagtacatcg atatgtatat cacacaataa agtcaatgca 725401 gcataactta gaatcgaggt agcgactccc cgtattgctc aaaatggaaa attctatgga 725461 aatagaattc atatgactct gagaactaaa ggaacattat gacgaacaaa attgctatga 725521 tgtgaggaat aagatgatac agtcctacca aataccaaag atcgggtcgt cgagggcggt 725581 atcatatcta gggagatttc ttttcaatta gagcatattc attatcaagt aaccaccatt 725641 tgtatttttt ttttcttctc aaggtagtta ttctgttctg acgtgcagaa gatgggcgta 725701 gcattgacac aaagattcag tgggaaacta tatatccata tctcatcctg gtttggaaaa 725761 tgaagagctg catacttata tgagggaaag aaggctaaac aaaatatacg taaagcaact 725821 atcaagagcc aatggaatct attttcaaaa tttgcgttct tccaaaacat ttatcccgtt 725881 tgatgcatta atgaaaatta tgaacattta tttccttacc acacgtacat tgggtgctct 725941 actttctttt ttatttaagc atataaaatg tacacagtag taaaatacca ttttaaaata 726001 ttatttgaac aatcatagaa cactacgcag gtattcttct tcaaaaagat agcttcaatg 726061 tatttcatgt atctgaaaac gctttgtctt gccattaaag atctggtggc cccgacaaaa 726121 taaaaaaaaa tactgaagga tgcgaggttc gaactcgcgc ggacaaccgt ccaacagatc 726181 ttaagtctgc cgccttagac cactcggcca accctccaaa gatttatact ttttgttgta 726241 tctcaaaatg agatacgtca gtatgacatt ttgagatcct aaacgttcat aaaacacata 726301 tgaaacaacc ttataacaaa acgaacaaca tgagacaaaa cccgtccttc cctagctgaa 726361 ctacccaaaa gtataaatgc ctgaacaatt agtttagatc cgagattccg cgcttccacc 726421 acttagcatg attcatattt tatataatat ataagataag taacattccg tgaattaatc 726481 tgataaactg ttttgacaac tggttacttc cctaagactg tttatattag gattgtcaag 726541 acactccggt attactcgag cccgtaatac aacacttttt atcgtatttc aggtagtata 726601 ccacatcatt atttgaagag tgggtgagtt ttgagataat tgttgggatt ccattgtgat 726661 taaggctata atattaggta tgtagatata ctagaagttc tcctcgagga tttaggaatc 726721 cataaaaggg aatctgcaat tctacacaat tctataaata ttattatcat cattttatat 726781 gttaatattc attgatccta ttacattatc aatccttgcg tttcagcttc cactaattta 726841 gatgactatt tctcatcatt tgcgtcatct tctaacaccg tatatgataa tatactagta 726901 acgtaaatac tagttagtag atgatagttg atttttattc caacattatt gtactcagca 726961 attgttgcga aacagacaag attaagtata ttattcaagg ccttgcttac ctagatgaac 727021 cattgagaaa tatacatatt gagcaatacc tctaggtccg aagttccgtg cctacaccct 727081 ttagtcagat ttagattata tgagataagt ggtattttgt ggaccaagtt tgtgattaat 727141 ctgatatcaa gttactttct taacgacatt aggacgccag ggtagccagt attattcaag 727201 tccatagaac agcctgtata ccttcacttc attaggtata ttcttggtta tgcgttattt 727261 aaatcctcat ctgccgctgc ttaaaaaaag cagctaaagt gttgcgtagg cacttcgaac 727321 aagtagtcag taatatcacc ttttaacatc taatcatcaa aagagacatt ttttgggatt 727381 aattgtttat aaaagctatg aacttaggtc tacagaatgt accaaaagtt atcctgtagg 727441 atataggaat ctacgaaagg ggcccgatac ttctatataa tatatatttt tatttctcct 727501 tcaattttat acgttgtcat tccttatcct attacttcat caattcttgc aattcaacat 727561 ccaataactt tgataactgt ttcccatcaa ttatgtcgtc attttacact gtatatgata 727621 caagtagtat gagtacacac caatagatga ttaatttttt ccgacaatca aatattggga 727681 tcataaacac acataatcgc catatccgtt aattcgggtt tcaatcactt cgtttgtcta 727741 tcgtatcgca gcctagtgaa tatttaattc tttcaataaa aaaggcttaa aatcaccatg 727801 aaaatcacaa gaggaatctt tcaacaagaa caatagtata caatccatga atgaaggagt 727861 tcatatttga ctagaactat acaaaggttt tgtactgttt ttactgtgag ggtagcatct 727921 catttatcca gaatctcaga agggagaaac ccaatcgcta aatcgatatt atcacccaga 727981 agtttcaaat aggcgattgt agaatataca cagggacaac cactcagttt atggcttcag 728041 tgcgcgccca gttctggagg aaagcattat cgaagtaata aaactttaaa aaagctctcc 728101 gcaactaatg aggattgcag tatccagata cccttgtttt ctgccaaatg aacactttta 728161 ctatgtcata taaacaaaaa gtgccatttc ttggtactgc ttcagtctta ggaatggtca 728221 atacgttatt attacttaaa tatacgatta ataacatgct ctgttgcgta tttagtaagt 728281 gtgtaaggaa actgtaatat tacctaaccg gtatcccacg tgtttcacga agggcgcttt 728341 tgttgttgca attataatcc tagttaggta aaaaaaaaat acttaattcc tatcatctac 728401 tagatacaag aaagacgtct ctgaattaca caccgtctct caaattgaca gattgcaaat 728461 accatctctt agtccaaagt cttatcctct taccatagta gtacattggt aaagcaaatg 728521 cagtaatccc aaagttgatg acagctaaag caatgtaagt attttcagta ccagatgcag 728581 ctagccaatc agaacaggta aaggtgaaaa tgcaagatat cgtgttgtta ataatagcag 728641 tacaaaccat accttccaaa accatatcgg ggtaacaatc cattaaatac gccatcgcaa 728701 tatcaccaga acaaccccat gcaaacccaa caaaacccaa cccgacgtat atagcttgcc 728761 aaggccattg tctagcggta ccgataccaa acatcagcaa acccgctggc ccaataattg 728821 cagttgcgat agagaagtat agtctaaatt ctgcctctaa aattcctcta ttgtgacgag 728881 ccatccaaag aacaaagtag tcactaacaa tgccagcaca gatacaaccg atgactgctc 728941 caataagtgt gggaacattc ataattgcga caccaaaatc actatagttc catggaggtt 729001 cgtagtaggc gctttcttga gtggtcaaat aaaacgtcag gaaaacgtct tgaatacccc 729061 aaaacatacc agacaaccac actggcggga ataagaacat tctaaggttg atctttagat 729121 atttgaaata ctgtttaaaa ccgtagcctt tcaaattagt agctttggtt aatattgcta 729181 ctctttttgg gtatggtttc aaatgctctt ttgaaccatc aatcaattcg cgagtctcag 729241 gtatggtaac ttcctcttca ttgttaactt cgaattcagc cgtctctgaa aggtctacac 729301 ctttctcacc catggctcca ggagttgata atttagcgtc aagatgacgt ttcctgcgcg 729361 acacggccgt attgtcagag ttttgtaaag tggtaccgtc ttcgtatccc gattgacagc 729421 tggtcaaagg ggtcatatac tggcctctgt cgaagtacgt ttcttcgcag ccaaatataa 729481 tagttattaa aaggccacca gatatgatca ctgcgaccca accgacccaa cggaagttgg 729541 taaatgcaga tatgtaccca gcgatcaatg ggcccaagaa cgtaccgata ctagtgcaca 729601 tgatatacac ggtcaatacg gagcccaatt ggtgctggaa aaaaatgtcg ctcagggaca 729661 gttgcacctg ggcttcagca caggactcac taatacctac aaacaactga gaccatattg 729721 tgtcgctcgt tcttttggcc aaagcaaacc aaagcgcacc aaagagacct aatgtggtgc 729781 aaactatgta cgtaatcttc ctgccataca agttagcaaa tggagccaag aataaagtgg 729841 accaaccaat acctaggaaa agaacaccag cccctgtgtt catggaatcg taggatatcc 729901 cataaatctc attcaatgag tcttgagcag caccagcgtc gttactagta gcggcggtaa 729961 acgcagttat aaaggccatt agaccaaaat gagccaattt cctccagcta gaccagttca 730021 gtggatcatt tggcgagtat gatggttgag ggattaggac gactcctgag gaggttttct 730081 tcaattttga ttcgtatata ataccatttt ccaaattttg ggaagaatag atgttaaatg 730141 tgccaggaat atagtccgga tgatccctgt tggtatattt gtccatctgt taaaaattta 730201 agattcacac tcgcaaactt tcttctatag tagttctttt ctttatattc gttagaaatg 730261 caaaagttgc gaagctgttt tgttatatcc tgtagattgt aatatgatac ttcgattctt 730321 tcggatttag tgtttacttg ctattcttct agtttcaaat aaataagata ataagggatg 730381 tcaacttggt agtaatagca tgaaatagta tcgtaaaatt aaggatgcta gcgctttcga 730441 caacaaaatg ggcttgtttt atttttgcag aggaggttca gtaaatatta cctcagagac 730501 tgatacagat aattctttct tattcgactg cgtatttatc tttatcgttt agattgaaga 730561 caatagacaa ttaaatgaat ctatagaaag gttaggaaat agtctaaact actatggttt 730621 gttaacggcg aggtctttag tttaattttc tgtctggaaa ataactttat cctaaaaaga 730681 aaattttcat caactgcaac tttttttgtt atgcttttgt tctcgctagg cgaaagctcc 730741 ctaaaaatat ccgtagaatt tcatatgaca caaccaggcc ttgatgtaaa cgtcaaacta 730801 cacatttctc aaagcttaga gagctgatgc atgaaatttt tgcattgtgt ggtattatat 730861 gtgacttaag aaagtaattg tacatcataa gagagaaaaa ttctgttcag agaagaacta 730921 tttgaatata ttttaaaaga taaaaaaatg tcttggcaaa aataagtaag taatgaaaaa 730981 gaaattttct cgaagaaaaa aatgaaaaaa atgactaagt actcaatatc cttgattttc 731041 tagttttcat tttcctcaaa aaaacttgtc cacattcatt ctctgaatcg ttcttctttg 731101 gtatatacta tcatgcgaat acgtcttttt tcttttgata ttaaaatatc tacagactat 731161 tttgtgcacc tataaaataa attttgtcat gacttgtaat tttcccataa tcgggactat 731221 ttaaggacca aaaatacact ttcgcccaac ttgctgcttg accaggactt tcgataatct 731281 cctaattaca ctagctagtt tttacttgtt atggtttgtg cagttgagat agctcagtaa 731341 aatggcttta tgtgttctga tcttataatg aatcgtaatc gaaatccaca tatttcattc 731401 atactgacgg agaataggtt aagcgctgct gctatggtac ctacttttac tctttgtggt 731461 gtgcgattag ttttgtaata caagggtact tctggtaata aatatacaat tattttatga 731521 aactatgata caggagggca gaagttctga cgatagagct acaaaaggta gtatcgacct 731581 aggaatttat aaggactgtt tttctttcaa cagcatctta gatgcatgta gggaaaacaa 731641 cgatgctgat aatgcagaaa actactgcat acactactga ggtgtaattc atgtttcctg 731701 cagtaaccgg tagtgtatat gggaaagata aaaataccag gcagaacaag gtccatagaa 731761 tacatataat atgaggaatc atagacatac gacgacggtt aggcctgctg acacaattta 731821 cgtcactctc gattctatga atgaattttt cctttttaat aacgaacagg aatataaaag 731881 aaggaactgc gtacgacatt agtaacaggg tgatgcatgc agtgataatt gcgttgaaag 731941 cggtactaga tcccataaat atacagccaa ttatcgttac acatatttgt gacaaaaaat 732001 gggcatataa tggagactta aacccaggtg tcaacactgc tagcttcttc aaggatttgt 732061 ttcccaagga accctcttta taaaatggtg cgtaactttt cccgaatgat tggaggattc 732121 gactttgcca ggttccactt gcaatgcctg aaacaaaacc tgttgtgata cacatacatt 732181 gcaggaagac actgagattc ctattaccag tggcctggta aaatatttct acgataggta 732241 aaatagactc aacgactgcc gtttggtcag tgatgcagaa aaacaaacca acgcaataaa 732301 taaaactagt tacaaagccc acaatgatgg tagtgataat aactttggga actaagaaac 732361 gtgacttact ataacccact tcatcaatca tgtgcgtagc agagtcaatg ccaacaaatg 732421 cccagatcgg attgaccaaa ccgacaacaa acgccattcc agacgaattc cagcctgttt 732481 gattatcaaa gctcccaaat atattagaag ctttgggcca tgggtctacg gtgttgtcag 732541 atcttgaaac aatacaaata atgaaagtca tggcgaaaga caatagagac gtatagagcc 732601 caaactgaga gatatagggc aacggagttg aataaatgtt gaaaagtgtc aaaacggcat 732661 tgatacactc gtaacccaca aaaacatgcc agtgctttaa ctcgtagtcc ggatgcaaca 732721 acttatgaat accgatacag ctcattgaca aagatgagca gatacttgcg gtagtaaaaa 732781 tggcaccgaa atagttcagc aaccctacaa ccatggaaga aaccttttga aatttagaag 732841 aaacttccac gttgaaagtt tgacaataat tctcgaggaa cacttcttca tcatcgtcag 732901 aagggtcctc gtactcaggg gttttcaaag tgactgattc ttgttccaac attttaagaa 732961 cccaaaatga accaccgctg ctgtttggca ggatagcagc aaaatctccc agagatatac 733021 cacacatgag actgaaaaaa gcagcaatta tcaacccata gatgataagc agtggccctc 733081 cactggcaat accaacggcc atcgacgctg agataccgac ccatgagcaa cttaatgaga 733141 acgcgatacc taatagggac caccaattaa agtgcttgtc aaacttgact tctgaccttt 733201 ctgaactaga cattcttatt tccgtcctgt gacgatctgg aacaatagac aaaaaaaaat 733261 ttctttcata tacaaatagg aacactgccc ctactctgtt cataccatgc tacttatata 733321 tagctgatga aagccttgca acttttttat ttaaactatt ctacgtcttg ttgggtcatt 733381 aatgactcca ccgatggcag ttcatgcaac tccatatcct gatcatgtgc cgtagtacat 733441 tgtgcaacct gtgccataat attgacaccg aacttcttca gggcctgcac gttgccttca 733501 ttcggttccc cattgagaat gaccccaaaa aggtggcttc tcaagccatt atcgcaaaga 733561 tgattccaag tcagcaatgt atgattcaga gtccctagcc cgctgcgtgc cacgacaact 733621 acgtacactg gatggccgct agtctcaatc agatgtttaa ttagatccgt cgtaatttcc 733681 aatttacgag tgataggaac gcaaaccccg ccggctcctt ctacgaccaa tggattctct 733741 gcgctccact cttcaggaac tacgaaatcc aacaacctga tgtcgacatt aggttcgtac 733801 tccatggcct ggagcggaga tagaggcttc tgcagcgcat aagtgggcgt gaatataggt 733861 ggttgccaag ttgatgcggc tattttgaaa tttttcaatg tctcggagtc accttgatct 733921 gactcaattc cagtttgtac gggtttccag tatgcagctt tccatttgtg taccaataat 733981 gttgatacaa aggttttacc aacatcagtg tctgtaccgg tgacgaatac aattggttgt 734041 tgttcttgtt gttgagattt gctgttcatg acctgtgcgc tagtgatttt ttgagttctt 734101 ttcactggcc tacttgtgga aaaaagtata tctctttata tacttcagta aacgaactac 734161 cagcgggatt ttattttgtt ttgcccaata attttgaatt ataaatagcc attgtttgta 734221 tatttcattt tcttttggtc gggaggatgt caacagcgca attcgttttc tattgctagg 734281 ataacaacta atgtcccaag aaatttcata tacaccagat gtcgcggaac tgctagactt 734341 tgataaaaaa catatttggc atccttatac gtcattgagt tcaccattga acgtttatcc 734401 ggtaaagagt gctcacggat gcaagctggt gttggatacc gactcaccag tggacgtcga 734461 ggtgatcgac gccatgtcgt cgtggtggtg tgttattcac gggtacaata atccagaact 734521 aaatgaggcc cttaccaagc agatgttaaa gttttctcac gtccttcttg gtggattcac 734581 ccataaagga gctgtgaatc tagtccaaaa acttttaaaa gtgattgatg aaccctcttt 734641 gcagtactgt ttcctcgcag attctggctc agtagcagtg gaagtagctt tgaagatggc 734701 tttacaatca aacatgtcag gggaagctac taaaaataga acaaagtttt tgacaatcaa 734761 gaacgggtat catggtgata catttggcgc tatgagtgtt tgtgatcctg agaattctat 734821 gcatcatatc tacaacgatc gactcagtga gaacatcttc gcccaagctc cctctattgt 734881 cgatggcctt ccaaccagcc agaacggttt cgaggaccat tggaatgcag aagaagttac 734941 cgatctcaag aagcaatttg aattgcatag tgataagatc tgtgctgtga ttttggagcc 735001 tatcttacag ggtgcaggag gtttgcgacc ataccatcca cagttcttaa tcgaagttca 735061 gaaactatgt aaccaatacg acgttttatt catcatggac gagattgcta caggatttgg 735121 tagaacaggt gagattttcg cattcaagca ctgtcaaaaa taccaggacc aacatggcat 735181 cagtccttcc gatcagatca aagttgttcc tgacatattg tgcgttggga agggcttaac 735241 cagtggatat atgactatga gtgcagtggt agtcaacgac aaagttgctt ccagaatctc 735301 ttctccaaat agccctactg gtggctgctt catgcatggc cccaccttca tgggcaatgc 735361 cctggcatgc agtgtggcag aaaagtctat ggatatacta ctgcgtggcg agtggagaaa 735421 acaagtgtct gcaattgaaa accaaattta tagagaacta taccagtaca tcaagaaccc 735481 agataatggg ctcattggaa ctgttgttaa gcgtgtgtca gttattggag ctgtaggtat 735541 cgtagagcta tacaagaaga cagatcccga gtggttccag aaaaagttta tatccaaggg 735601 agtacatatc cgacctttca actgcctgtg ttacattatg ccaccatatg tgatcacgac 735661 agaggaattg acgaaggtta atcaagtctt gattgaagta ttacatgagt ggaaatccca 735721 cataaaccaa tgatatacga tctcatcaag tcatttgcca aggaattctt atttcttgcg 735781 taaaatgcat tcttttacgc tattatttat attgatataa ctcaaaataa aaaatttatg 735841 gttatttatt ctagcggacc tttatatctt acttttctta tcataaaact atgtcgaagc 735901 ctgctgcaca agagaaaatt gactagttca gggcaagaac gtatcacagg aagtacgagt 735961 tgagaaatct ggaccgaaat ggtccgtggt cgcctacccg ccttctgtgc catcacggta 736021 ctctcttcta tgttctccca ttagcgctag ttacactcct cagcagctga cacatctcac 736081 gatcctatct tttatttatt atgagaagaa cggaaaagat gggatattat aggctcagct 736141 tactcttcaa gcaactactg ttgaaccggg tcgtacaact catacctttg aaccctctgg 736201 taaatttttc cggcagagtc aagattatta ttgaggcaaa cctgtaaatt tccttcagca 736261 tttgattatc ttccgctact tgaaattttg cactatatct tcctctatta acctatccgc 736321 agtaactatt cacaagacct tgaatgtagt aaacgatgtc tatataactt aatattgtgt 736381 aagatcttac aagatgtact gggcccaggc ttttcacggg gatcaaaccg ttgctctcct 736441 agatgagaaa acgctttgcc atcacactga agtagcatgg gcagtatttt ccctcgaata 736501 ttgttattat caaagcaagc aatatcagca gtagttttta tttcaacata taagatcacc 736561 tatgttgcaa tctctgcaaa attagtaatg ttaccctcca agtaattgta tgacctctct 736621 tctgaaggta aacattgcgc ctctttgttt aaagcagcag cactagttta tcatggtttc 736681 gttacctagg aaaggatcgg tagtgctatg taacacttgg aaaagatgaa atttgttaac 736741 atgaaattga gtcccttgtg ttaaggtaaa agtgccatct ttaaaaacgt actctgcaaa 736801 aaatggtatt gcgcatacga agaattaaga aactggcacc attgatcttc acatcattgt 736861 tgtctctcat tgttcttttt agggtctacc gacagtatcc attctccgac catttcgaaa 736921 cacgcagaga agatgatcgc tctggcaacg tgcactgctt ttctagactg cgtcaaatag 736981 aggaatatga aaagccggaa ttgacaagta aattctatga accgaataga tggaaatctt 737041 ttatatctta cgtgaccagg agtcgcaagg atgtgaaaac tgtgtcccga tcgctatcca 737101 atttggattt gtatcaaaaa tgctcaaaag aaatccgtgc tgatcaggat atttcccttc 737161 ttcatagcat agaaaccaag ttgttcccat atataaactt cacagcccta aatagtgaac 737221 aatctcataa tttttggcct gttcataccc gatttgatgg aacaaagtac cgtggacagg 737281 tattacaatt ttcttctgag aacaattcgt tcattggaac ttcacccatt gaattcaagg 737341 ctagcgaacc tttttgggag aactggttga attcagctct tcaaaggaat tcaaaaggtg 737401 tggtaatgag cgtatcggaa tatctggtgg ctgatacaat tcgactaata agagttttgc 737461 ggctgttaaa taattccctt ccaattgaaa tcgttcacaa atcggattta catgagagtt 737521 ctcaacagct cttgatagca gcagcaagag aatctggatc cttaaattat ccccctcagg 737581 aattgtggtt tctggatgtg aaagacatgt taaatgacga atatttagcg agattcaaga 737641 gattttcgaa taagtggctg gcaattacct tttgttcatt tcaaatacca atctttttgg 737701 actctgatac tgtacctttt gtcccgttgg atacactcta tgaaattgac ggatttaaaa 737761 gaacaggtac actgtttttc aaagacagga gttttccaac ctccaagtta agtccactcc 737821 aagttaaagt tttgaagcag ataatcaata atagtctgga tgtatcctcg gattcggagc 737881 aaggttttga aatcttaaaa cataacctaa acgatgagat ggcaattgat gcaatagagg 737941 ccttgatttt caagaaacaa aaacattaca tggacagcgg cttagtgata ttcgataaac 738001 aaaaacactt tttctgtcta ccaatcgcaa taatgctgca attttcgcct atccaagagt 738061 ttttccatgg tgataaggaa tggttttggc ttagtttgtt tatttccaaa aaagagttta 738121 ctttttatcc aatagaggct tcgaatgtag gaagattaga gaagccggag actctagaaa 738181 gcagtacaat ctgttctacc cagctatctc acacggacgt gtacggtaat cttttgtggt 738241 tgaatggcgg attatccgtt tgcaaaaaaa attgttggaa ttatgatttt acaaagcgta 738301 aagagattgc ggccaaatac aaaagcgttg atgaattacg gaattactat caatcacctg 738361 tgaaactcga agctgtcata atacccgatg tcagcaagtc cccctggtcg caacagagcg 738421 aatgcgttat gtacagctat tgcacacatt ataggaaggg acagtacgga aaattgatag 738481 agtttacaga ttctcaaaag aaatattacg agaaagttgt agaattatgg aacaaggttg 738541 tatagagtat gtttcagtat gagtacggtg aatttcctat aagtttttaa acttttagat 738601 ttttctataa agcatgttaa acccttcttg acatcgtttt caaacggcat ctttcctacg 738661 gaactaggct gtttttgaga tatccttatt taagttcctc ttggcacaat gttattcccg 738721 catttatatt tagttaacat tatgtgaaat tcgctcataa aaagagcctt agctctttct 738781 tcattttgcc tcaagaaaac tttaaaataa agtaggaatg ccaacaatac ttttcttcag 738841 taaaagacga atattggcgt agaattttac cggtaatcat atatacttgg cttagaacac 738901 tgacacatgc atttttctct ggacccttgc acaaatcatc agtagcgcct gaatcaaaaa 738961 ctaacaaaat accatatctg ttttaaacaa ataagtatat cgcatgaagt aagtttcccg 739021 cacgtaaaac tactacaaca cattttcgcc tagaattata agaatgttta gtgcattggc 739081 tccaagcgag taattgtacg atgcacgtgc ataaaaagtg ctcagtaccc agttccgcta 739141 ttagcacagg gaaattttcc ttacaagcga gcccttcaat agcttaggaa gtaaggttac 739201 tttggcgacg gccatagatg cctgagtagc ctttttcctt tttccttccc tcaagaatgt 739261 gtgaaatgac gttttcggga taaagcgggc gctagcaaga aacttctact aagagtaacg 739321 tggctgagaa gagaagaata ataaaggtat gccatggaat aattttagaa gagggggacc 739381 tgcttcttag aaacacgtaa tctgaatccc agagcaactg cgtacaaaac aagatcttgg 739441 ctttgtaagc aggaacggct ttttccgata gaagaacgtt ttttgttttt ttatgcaaga 739501 ccgtctaaaa atttgcaccc tatttaacat agacactcaa cgaataccat aattgcacct 739561 ggtttcatag gaccctgagg gaacaatact caaaagaaca aagactactg gtagaggtcc 739621 cgatatatcc cttcactgcc ggtgactatg gtaaaaatga ggttacaatt tctgtatcgt 739681 tagagaaaat ttttttcgtt aaggcaaacg catcagcgtt tacataggga attcctagcg 739741 tagtttaatg agcaaggtac atcaaaccct agtagttctt gcagttacac aaaatattcg 739801 ttaaaagcca gtttttctcc tctttcttag tcttggctga ctctcatata aaacaactag 739861 agaagctgag aaagactcca gttaatcgtg tctccccagc gtctatttct tgaacctgag 739921 atggctaaat aagcttaggt aggcaaaacc atgttgttgg tacatattat atctttcctt 739981 ctgttcttcc agctttcggc cgcaaaggcc ccacccagta aaacgtctct aataaatact 740041 catgagagaa ggtcgatata ttcatgctac gttggtttac gtaaagaaac atgggggttc 740101 aatgggtccg ctatatgtcg gtatgaacca gcaatccaat cgatgcttta ctgtctttac 740161 gaagacacgc atgagaaagg gtattcaaat aaaactttgg agaaaggttt tgaagaaatg 740221 agacaatttt gctatacacc aaagtttttg aacatgactg atgccgagtt ttacacctca 740281 ttggataatg gaacatacta tatacaagat caacctaaag ctggcatcaa tatcacttat 740341 cctatcagac tgaacactac actaagaaaa gcatactatg atgcatacta tggttactac 740401 tataaccatg acattccgta ttatttcggg ggcattatct gtgcatactt tgtgggtgtc 740461 atgttgcttg caggtttaat tcgttttttg aattataccc caataaaaaa gattatgttt 740521 cagcaaaagc tagtcaatta cgtgagaggt tatactactc tacccactct ttatgaaaag 740581 catgcagagc ccttctcgta cttaaaagtg ataacaggct atcttcctac taggtttgaa 740641 acgttggtta ttttaggcta cctcatactt cataccattt tcatggccta caaatatcaa 740701 tatgatccat accacatcat atttgccgct catagagcag aagtggcaca ttttgttgcg 740761 tacagaagcg gtatactttc ttttgcacac ctgccactca ttgttttatt tgcgggaaga 740821 aataactttc tccaacttat ttctggcttg aagcatacct cattcattgt gttccataag 740881 tggctgggaa gaatgatgtt tcttgatgca ataattcatg ctgccggctt tacgaactat 740941 tatttgtatt ataaaaaatg gaatacggtt agattaagag tctactggaa attcggtatt 741001 gctaccacct gtttagcggg aatgttaatt ttcttttcca tcgcagcatt tagaagacac 741061 tactatgaaa cgtttatggc cctccatata gtattcgcag cactatttct ctatacttgt 741121 tgggagcatg ttactaactt cagcggtatc gaatggattt acgcggcaat agcaatttgg 741181 ggagttgata gaattgtacg tatcaccaga attgcactct taggatttcc taaagcagat 741241 ctacaactgg ttggatctga tttggtccgt gtaacggtta aaaaaccaaa gaagttttgg 741301 aaggcaaaac caggccaata cgttttcgtt tccttcttgc gtccattgtg cttctggcag 741361 tcgcatccat ttacagtgat ggattcttgc gtaaacgata gagaattggt catcgttctg 741421 aaagcaaaga aaggtgtgac aaaactggta agaaactttg ttgaacgtaa aggcggcaag 741481 gcatccatga gattagctat cgaaggccct tatggctcca agtccaccgc ccatcgcttt 741541 gataatgtat tattgttggc aggtggctca gggcttcccg gtccaatttc tcatgccctt 741601 gaattaggaa agacaacagc tgcaagcggt aaaaactttg tacagttagt catagcagta 741661 agaggactag acatgctcaa cgcgtgtaag aaagaactaa tggcattaaa gggcttgaat 741721 gttcaagttc acatttataa ttctaagcaa gagctagctt cggctgaaaa aatttcctca 741781 aatgaagtca aaaacggtga aacgacagca gagaaggccc catctagtct aagcaattca 741841 gaaaaagctc cttctgaaag tgaaaataca gaactacctc tttccctgaa tgacacgtct 741901 atctccgatt tagaatttgc cactttccat gttggaaggc caaatgttga agaaatacta 741961 aatgaatctg ttaaccattc tggttcactt gccgtcgtat gttgcggacc acctattttc 742021 gtcgacaccg ctagaaatca aactgccaaa gctgttatca gaaacccatc aagaatgatt 742081 gaatacttgg aggaatacca agcctggtga acaatttttc atatttaagt aaacactcaa 742141 tgtataatat cctctaactg ttgtaatttc attaacgtag atggtttgcg ccttttttag 742201 gggactcttg ttgattgatt ctaactactg aggcttaagt tgtttcaaat aacacttttt 742261 cagaaaaata atcgtattaa aaagcagaaa aatcatacgt aagatgacag aagcttcata 742321 tttagtaact ctgaattgta taacacacca attgccgata gaatatgaac caatcgatct 742381 tcagcgttca tgtacttaat ttaactacct gtattttctt ataaagataa aattggtgta 742441 taatgtaagg accaagagaa aaaggaatcc cgcatcccaa gcaatttcta gtggactatt 742501 tcttcaaaaa ataactcaat aaacacctat ataatgttcg gaggttatac tttagtgttt 742561 tagaatgcag taccaaaagt aatatattga attaataact atatgatgtg tagctaagaa 742621 ttaaatagta aacgtcttct gaaacctttt aagaggtaat tattggtatt ccaaattcat 742681 atgtggaggt aagggagaca caaaattatc tggaatgaca gcgtgctgac acctataagg 742741 ttccgtaact tcaaatgcct tcattactca acataggaaa agtgaaagtg tgtgcctcta 742801 aaatatacgg aacatcgtcg aactaaaaaa atccattaag caaagtcaga aacagcatgc 742861 actacaagac atttggttca tcatgaagaa tgctcaattg aaccatcaat cactttctct 742921 tgttcgatgt tagcattatc ctcactatca gttgaatcct caatgctttc ggtttcagtc 742981 ctcgcatctt cctgaacttc aagatctaaa agaggctcac tctcttccag actggtctcc 743041 aagcggtcca cggtatcacg taatgccttc acacaagcct tcaaaacaga tcttgtgctt 743101 gacccatttt ccttagcttg agataggact gtgatataag aagcatatgt ggtagcgaga 743161 aatagtatga ataaaacggc ttctggtaaa atatctattt tagcaatctt acaagaacct 743221 gaataatcaa agtttatacc ccgtggcata cttgagcagg acatagaacc aaattttgaa 743281 gctagagtta cgaaagcggt aaaccacagg acggtctgaa caatttccat cacgaatatt 743341 aacagaacag gcaaaaatct cacaatccca aaataaactg aagatatgat tgaaacagct 743401 aagctcaatc taaggattcg atccacttta tagtttgtga ttatggcaaa actagctaac 743461 aacaagttag ttacagataa gccaagttgg aaatatctta gtacgtggaa agtaacggat 743521 gttgttgtta actttaacat atatgtattg agttattatt atagatcttg acttggtaac 743581 aaaatatcaa gctgtaagca ccgcctgtat tctcctattt atggttgatt atattttact 743641 tctgttgaac caagaaaaaa atagcaactc gaaaagtcgc ttattcattc acttttttaa 743701 tttttttaca tatcgcatac gtaattggaa acacgcaatt ttaactttgg gcaaatacat 743761 aaatcatttt gagaagttgg tttttagtct ccgagagatt ataaaccaac atccttaaaa 743821 gatagtattc atttctcacc tgccaatgca agagcagata ttattcagca agcagtacag 743881 caaatcggaa gcgaattcca atgacaattt gcagaataag attagaataa tatattgaga 743941 ttaaagaaaa ggttatgcga attgcctaac gtctttaact ttgaagcggc caaactctaa 744001 aaaaccttgg ttaaaataca agctttggcg tccatgcaaa ctgattacat cattcagtat 744061 aaagtgccat ataaaagagg cacacacttt tccacaactg gtttgaatat aatagaagaa 744121 taaatcagaa ggaaacttta aatattagta atatttattt atggccgcta aaagattagt 744181 ccggatatat cactatagaa atggtaaaga taatacacta tcatttccaa atgtaaaatt 744241 tgttgataga acgccataaa aaagaggctg actttttgtc gtccaagttc ttcgaaaaaa 744301 tatacgtcaa tggcacccga tatatagctg gatttggacc agtatatgtc taaggaaatc 744361 taacaccttt ttttcctgag ccaaataagc ggtggaattg aaacagctac caaaatcata 744421 ccaaatccaa ccgcaattga aagccccaat cttgtgccat aaagagctgc taatacaatc 744481 ggtgccacca gtttaccaat cccagagatt gctccaattg aaggcatcaa ctggaccttg 744541 agtttggggt cgatgtacat ggaaaaaagg gctggaatgc tcgaagccaa aaagttgtac 744601 cctaacaatg taatcgacat cccagctgaa aaaaatatac cagaatttgt gggtggcatt 744661 gatttatgct tcaaggcttc ggatgctcca atcataaaag cttgtcccag caatgaaaca 744721 aacaatgcaa agatggacag aaaaacttga ccgctgtaca gcgaatcttt tttctttacc 744781 tcaacggtct cacttccagt tgtatctgac tcttctaatc cgccatcttt ggctctgccg 744841 caggagcacc cgacgtttat taactttgga gcgaaatagc ttccagtcac accaagtata 744901 gatgcgacca taaacgctat gccttgaaac ttggtgtccc agttaacgtg gagcgtcagg 744961 aatagtggca taaaataaac tacttcgctc ataataaatg acgataggaa catgctccat 745021 agtaaaatca agcaggagat gagttttttt ctttcgactc taaaaaattg tttcagagca 745081 ctgaaaaggc tattttccga atttgtaact ttaacctcag gattttccag aacgacaact 745141 aataaaaggc atactgcaag aattatgaaa ctggaggcaa atgtcggtgc attgtaagag 745201 gcaatgcgat accctttaat tttaaaatcg caatatccaa aaaatatgac aattaattgt 745261 gccaacgcca tgaagatacc agccgctgct cgataaattg atagaagctt gaaaacgata 745321 cccctatctt gtgcaattga catgatgtaa ctgaacacta tagcaccaga agcagatgct 745381 gcaccacata taatacgccc accgagaagg gtgtttagcg acactgcacc gccgcatgaa 745441 tacaaaaaat tacccacaaa ggataaaaag taaagcccca ctattaccca tttaatggac 745501 ccaagaaaag cagcaatatc cccaataatg aatgaaacaa aaacttgaac tgctgcagaa 745561 atggcttgaa ttctgaacaa gaatttgtcc ggattggttt ctccgttctc taaattgtta 745621 gcatactagt tcattgaaat tatcttagat ttacattaac acttacttct ttgatgtagt 745681 caaccacact tgagagatat acacaggagt cgaaactgaa ttggacagct atcaaaatta 745741 cagccaagta tttcaaaaac atgtgtttct tgacacctaa gatttttttc attttaattt 745801 attgtaccac cgtcgagtga aatggatgga tttgtaatgc aattgagata caattaagaa 745861 gaacgaaaga gtacttgaca actagaaagt aatgttaact gatcttttat atgatgatta 745921 tttattgacg gcgattcttt tccagattag gaaattttgt tccgcttaga atgggatagg 745981 cttgtttggg cgctatactt ctgtatcaaa atagtaaaat caacttattt tagtaataga 746041 agagaacagt aggcgtttgg taattctaat tacctagact gtcccccatt tccagacagc 746101 tgtcccatat ttttttgaga ttccgacgtc gaagcgaaag actagaagaa taagtaaagt 746161 ggtcctttgt aagcataaag acaaaggcat gtgagaaaag taagtgtctt cgcgattcgc 746221 cgttgtaaat atgtatcagc tttttttact gccttttcct ggcggatcac agtaatgtat 746281 tttttttttt atataattcg agctctacac tcaagcatac atatatagaa tagctcagtt 746341 ttaatgggct ttctcgagaa ctattcaccc agaaggatat cctgagcctt atatttagat 746401 gtaacttagt aaagtgagag tattatgaat aacttttgaa gctaacaaaa tatcagaaat 746461 taaacttcat tcaagaatgt atttatctag aaactggtct ttggcaaatg gctccgatgg 746521 cacacatgca atgttcttgg taaaaactaa tttattatta ggccagtaca gaataaaagt 746581 tgtcataaga aaacttcatt acattttatc tcctctggca agtatccaaa ttcgaaaacc 746641 tcagaaacca gcgttccacc taaagtttgt ttgcccgtat gttaaaacag tagctgccaa 746701 gtcacttgag tttgaagaat aatctgatgc tttttacata gaggtctatt aggctcttta 746761 ctttgtaagc atctcgactt aaaaaaaaaa tctattgttt ttacgggcat cgctgaaaaa 746821 ctgtgtctgt tctctttgat gctgtcatct aagattcaat taaagtcgac catcaagttc 746881 ccttaataat atcccttgtg agagcttaat ctaaaactac aaaagcgttc gcaacaagca 746941 gtatggacag atctaaggac gctagaaaga gatctattag tttggcctgt actgtgtgta 747001 ggaaacgaaa gttgaagtgc gatgggaaca agccatgtgg aagatgtata aggctaaata 747061 caccaaaaga atgcatttat aatattgata aaaggaaaga caagagaaaa atcaaaaacg 747121 ggtcgaaggt ttttttattc aagaataata ctatcgataa cgggaataac tctatactag 747181 agaacaaagg actaaatgaa gacctttctt ctcatatata tgagaaagaa gcgccaaaat 747241 tcgattcaga tattgatata tcaagatttg gcacaaatga tgctgtgatt tttaataatg 747301 acgggtggga cacttctctt ccgatcgatt ttgatttcga tgagtttaac actgagacaa 747361 cagatttcga tgacttttta aaactattag gcgataattc accttcaaag gaacaaaaaa 747421 gtctttccta ttcacctact gctacaggct taagcggtgt ggttaaagaa actgagagcg 747481 aagataacgc tcctacgagg tctcggctaa tcgatgtctt gtttgagaac aagcttcact 747541 ccgtaccagg aatatcaaaa tggcatctat atgagctgga atcccaatac ccaaatttgg 747601 aatgtacaga aggaaatagt gatgaaaagt ttttactttc aactgtattg tgcctggggt 747661 cgttgaccat acgaaaaagg gaactattga atcattcgaa catagacaat cgtccacttt 747721 tgccggagaa tagtatttca aaactgacca ctgatgcttt taagtactat aatgctgcga 747781 aaacgcttgt tcccgacttg ttatctcatc ccacaatcga tggattttgc ggcctcgttc 747841 taatggcaaa tttcatgacg atgatgatat ccttagagca ccaattatat ttgagtataa 747901 atgctttaca acttgctgtg gctttaaact tgaacaacaa tacaaaatgc aaggaattac 747961 ttgagtcgaa cagcgacgga attggtgtga tcttgctttt ttggaacatt tggtgttctt 748021 cttgcatgtt ggcaacaatt catggaaaaa atccttttat cactttggaa caaattacaa 748081 cacctctgcc gtgtgaaata tccccccgca ataaaactaa taaacttttg atagatttca 748141 tgcaaatcag aatcaagcta gccactctac aaagtaagat ttttcaacgg ctatatactt 748201 ccagcaccgc aaacgaggta ccattcgtaa acttagaaag agaatttgag gaggtttcac 748261 tccagattac caggttaaaa ggctttccga tattcgaaga acatcttttt tacaggagca 748321 gagtcttaat gttagagcta tcatgtttaa gagctcaagc ttcttttcta ttatatcgtc 748381 cgtatctgat cactggagaa tccttacaag cagtaaccat ggcaaaatca ataattcacg 748441 aaatatggag tcaatacact aaacagtttc ccgataacga aaaggaaagg catgaacgtt 748501 tggattggaa tttttgttat cctttaagaa cagcgtcact gacattatgt atttcatgta 748561 ttatactcct aaggtataag caggtggtgc agttccttaa aggtactgaa ctatttgaat 748621 acattctagc attggaaata ttgcaagatt tagttcaggt acttcctatt gaacaaaacc 748681 ttattgatat aatcaaatat ccgatcagtc cagtacagct gagtggtgat agctttgtcg 748741 aattttgggg tcgcatactt tactaaaccg tttcctagct gattttttga cactttattc 748801 agaaatgacc ttttgagata caagtttact aggggaaaga tccatatgac atggtagtag 748861 gtttaccctt caaaacaaca tagatcgtaa aaaaggtggc tgaagaactt actaaaaatg 748921 ttatatgctt agattaatat attgtcaccg ggctaccagt acaaaccctt gataatgcga 748981 ccagacatct gttttgactt atttatgagc aataatgggt aacaaaagaa cgctctgagg 749041 caactctatg tgagtcgaaa catatgtgtt tttggcaatt aaacaaaata cgagagattc 749101 ttctcagaaa acattgtcac aagaacttag tatctttaat tttctgcaaa catactgatg 749161 atttcttcgg caatagcaac tacgtgagtt tcaagcgcaa aatggccagt atcatagtaa 749221 acaaccttta aattatcaac gtctttccga taagcttcag ccccggcaac gctaaaaata 749281 gtatcattcg caccccatgc aactagcaca ggaatctttg aatctctcaa gaacttttga 749341 aaggctgggt acaactttat attattctga taatcgaaaa ataatctcaa ttgaatatcg 749401 gtctggccgg tacgctgaat tagcgcaata tcaagcgtat aagcggcggg atcaacagat 749461 tcgatagctg gtactccatc atggtactgg catatgacat tagctggatc ttcaaggtac 749521 gggataaggg atttaacaaa taccggatca ctttgatatg acttccaata ttccttcaac 749581 ggaccccaaa agcggtcatc gagaccctct tcgtaagcat taccgttttg agtaacaatg 749641 ccagtaattc tggagggaaa cttcaaggct aaccgaaaac ctaccggaga tccataatca 749701 aatatataca tggcaaattt ttcaatactc aaagtatcta acaaatatcc tatactttca 749761 caaagggaat caaagctgaa cttgtagttt tctggcgttt ccgtaaatcc gaacccagga 749821 agatccggag caatgatgtg aaactgtcca gctagtaagg gaatgaggtt cctgaacatg 749881 ttggaagatg tagggaaccc atgtagcaat aaaattgtgg ggttacctgc tgcaccggcc 749941 tcacggtacc aaacctttac accgtcttga acttgaatct tgtgaaatct tgcaatgata 750001 tttgacattt ttgtccttcg tccaattctg acagtgaaag aaaagtggtc aagttcagtt 750061 aatttgatcg tgcttatata tgttcttttt ggctcctatc acttttggct cctatcactt 750121 ttgaaatttc tgtcacgatt atgtgcggcg cagtccctag gcaagttaca gacgaatggc 750181 atgcagcgcc gtctgtggaa aagatgaata ctgaattatc atacctttaa atgactatgt 750241 taataacaaa ggtgaatgga gatttagaaa atgcacaata ttgagaaaat gcatatgcgt 750301 actttttgtt agcaaacata cgattattta gtctattaaa aaaatctatt tactcgtcct 750361 cgttgcgcac agcagttgaa tcaggcttgt gaatagcact acgtgctggc aatgcgtctg 750421 gaatattgct agtggcaggc tggtctatct gtgacgtgtg ctcttgttcg ggtctgtaag 750481 catcttcttg ttcaatttca aaattactgt cttgacttgt gaaactggat aaatcgttag 750541 catcttcatg caagccatct gattcatctg aaaactgacc ctgaagcagc gaagagtaag 750601 taggaccttt tctgttgcca aaccttgccc ttaattttga agaaaagcgt gctacacctg 750661 ccttcgtgcg ttgaaatgca gacttggtaa ttaaagaaat gcataatcct agtcttacaa 750721 tgatgttgac aactctatcg gtcctattgt tttctatcag cccatcgtct cctaatctta 750781 tttcttcaaa tcttgaaaat cccccatttc tcctgatacc tctatcgtat acaaaccatg 750841 cggcaaagaa aataacgaga agaattgtaa caaaaaccag cgcataagcg ccggtgttta 750901 tagaatattt ttccctgaat gccttttctt ttcccggaca aggatgtggt gctaaatgtg 750961 catccaattt cagcccacct ttacaggttg ataagggaat ttttcgatag ccagaggaat 751021 catagtattc aattaagtcg ggttcctttt tgcagatatc ggcaccattc gccgaactta 751081 agcctttgac taatttacaa gtaccatcac tggctttata aaaattatag tcacattcga 751141 aatcttgcct cgtacatgaa cagtttttga cgttcctcga aaattcagaa agtggaatat 751201 tcccaataaa acatttttca tcggttttac gtaaaaactc ggtttgatga ccaaatagac 751261 aaccagttct ggaacccaga ggagagtact taaaatctgc ccttttttta cccgtaatat 751321 caaactcaca ttgcctctcg aagatgtttc taaaatcaat tgtatacgtt ctgaatgaac 751381 cactacccat gttttttgct tctccaaata gcaaaaacct caaagcagaa tctctgggaa 751441 cggtgattat atcctttacg aggactttgt cgccacagaa tttataatct ttccatgttt 751501 taccaaaatc ggtggagtaa gaaatagaat cagtttctgc gttttcgggg accaaaacca 751561 agactccacc atgatcaccg tactcccatt gatgggggcc ttttttaacc tcagtccacg 751621 tctctcctcc atcagtggtt aaaaaagtgg aacactcctc atatggtaga agcttatcgc 751681 caacatttcc gacaccaaac atcattccta acgcggaacc ggaggaatat gtatccctga 751741 tatccttacg ttcagtgtaa ccatgcaaat gtagagaaca tttatctaat gatacagaat 751801 cacagggaaa ctttttccct tccgaatcct tctttggagg cttcaaaaag ttccaatctg 751861 aaccgtcatt aaaggtgatt ttcgtcttca attgttcgtc ttccttgttc tctccaacct 751921 tttccctatt cgaaacgatg ttggtaataa taataccttc aagaccttga actttttcaa 751981 agtcgacata accgaatgtg tttctattaa cggcatgctc taaagtgaca aaagaagtac 752041 cattcgagtt ggatttcaaa aggtttccaa aatcgtgtcc tgattctaag tttgttgcta 752101 aatgtaaaaa tatcgatcct ttctcagatc ctaaaatagt gaatgcctct tgcttactaa 752161 catcttgacc atacgggaat tttgcctcgg caaactcagt accatcaata gttacatatg 752221 ccctcaactc attgtcttca tgaggtacgg caacaataat atagccacca gtggacaagt 752281 agccgataat gttttcaaag ataattttat tatcaccttg gaaaaaatct atcgaagaaa 752341 ccaagcttct tgtttctgaa gacttctttt ttacttggca cataaccatc tcctcatttg 752401 acggatattc aaagagtgtg cctgcaaact cacaatgaat tgcattatca agcatttctg 752461 taaaagtttc acctccatct ttggtgaggt atgctactgc atgacattct ggacttaaga 752521 ttgattcaca attcttgcca ccatagtaaa taaaagtatc ctgtgcttta gcactaaaat 752581 ctagtggcat acctaattgc ctggcttcag gtaatttagc tatcataaaa gagtgtcctc 752641 tatcgtgtgt tgagaatatg ttacctttag agccaaacaa atatgctgaa gaattgaaat 752701 atgggttaaa cacaacttca acaatttttt cgccgttagt gtcaaacctt tttattgttt 752761 gtccaccatc gtgggatata taggcgtctc ctatcgaatt cagcatgacc aaagattcgt 752821 cggcaactgt atcgaagtat tggtaaaatt taatttcgaa gtcaaatttg ttttcagtgg 752881 tcactatttc cctgtcactc gaaccctcct ctggaatttc gtcacacgga atatcaacgg 752941 gttcaatttt catgggtgtt ttacattcat cacctttgat taattgtaat ggctctacta 753001 acacagattt atccttcgat ttgtcacata tgttggaaaa ggcaatcaga ttataatctg 753061 gtatacacag gccgtttgcg tccctaacaa attcaaacga acattcgtag tcggattcac 753121 cacaactatt acaaggcgtt tcatctaaac tcaaatcttt gaatgctttt tttaccaaac 753181 actgggcgtc ttgtttcctc cttctatact tgtatttggc gccattaaca catttcccat 753241 ccgccaaatc ccaatcttca aaatcttcct cctcacacgt tctagagtcg aatgctgctg 753301 aaaaatcaat tatatactcg acacctttta aagaagttat actgttggtt tcggaatcgg 753361 tagtggcaaa cgttccttta aaaataaatt ttgagccaga tccatctggt gttggattta 753421 tcaatttgta gggatggaca gaacttatgg cattggtcag ctcatattca ttccatgttc 753481 taccttggtc caaagaataa taaaattcag attgaaaatc gccatcttcc tctggatcat 753541 atgggatata cacaataata tttcccaggt caccagtagc atataaccca gaagaattat 753601 gaacaaatct ccacgttaaa ccgccatctc tagagatgaa agttttttgg tcttcccaat 753661 cgaattcact accgtcgcca acggaacctg tcattaacat aattccggca gtaggatttg 753721 agatttagat actataaaaa gggttctgga gcgaacatct ttcaggccta gtgatatcac 753781 aagggaatga atctgcattt tcctcgtcaa ccactttcaa atttgaccat gtgaggccgt 753841 tatcaacaga tattttagtt tcatatctgg ctatcttttt attatatttt cctttgttat 753901 gagagtagtc aaaggaagga tgaaacgagc caattattgt tccttctaag aaatgaggag 753961 aagcaatatc aatataacca aagtgaggat ttattgtcca ttcaacaggt aaaaatttca 754021 acccttgaga atctgatatt aaaatttctg agggagctgg ttggtcgttt ttttcatctg 754081 tgaatatcgt agatatagga atgattattc ttccaataga atcttcataa attccataca 754141 tatggacgtg ccgtacttga gcaggtagac gtgccttttg aaaagtagac gcatcattgg 754201 atatccagat gtccatgggt gacatttcat tgtatctatc atcttgtgtc gaaacgatta 754261 tatgtgattt taatatcttg tattgataaa taattttatc attaaactca tcaaattttt 754321 tgaaagtttt acctccatca gtacttaagg ctaattgtgt atatgcggca cttaagtgac 754381 gatcgctatc gtaaccatgg ttcgagaaca aacatagtat cgaagcgtcg ttaccctcaa 754441 tatcagaatc cttgctagat ttgacaaagt tgcagcttga acttgttata tggtcatctt 754501 ctttcttttt caaggaaggt tcgatattgt aaaaggattc cccatcgttg gtaaagtaag 754561 tttcattttg tatttggata taaccattgt cgtttataaa gcaagggcaa tctgcaataa 754621 ggtacttttt atctgtcgga tgggtagcta tagagcaaga agtacccaaa cgacagtttt 754681 cagagacggg tatagtcaga gccctccatg attttccacg atcatcggtg acgtaaaatt 754741 tgggtgataa atgtatcgaa acaaaagccc tgtcctgtcc atgcaaagga tcaacaatta 754801 attcgagaat atgcccttca atttctttga ccgcttccca attttctcca gaatcggaac 754861 ttatccacac gacttgatta tctaatctga ttaaactgtt ggaatcgtca aagctctcta 754921 gactaaatga atattctgaa agagtctccg ttactttggg gacgaattcc tctgcattga 754981 gtaacggaat aaagagacat gtccaaatcg tgcatatgac ttggagtaat atcataattg 755041 aggatctctt accttttctt agttcaaagc tttttttcaa agctcggaac tttatgctac 755101 gattcaatga ctaaaaaaaa ggtagcggat aatcttttgg ttgcaaattg gcggcattta 755161 aatatatttt gggttgcaaa tattctaaaa atattctcat aatattctaa aaatatctag 755221 cctaggtaat tgcaattatt ttgagtctgg ttattttgag ttgaccatgt tcacttcctt 755281 ttcagtcatc aagacaacgt gtttaccatc taatggggaa tcaaacagat aaaactagaa 755341 actgagcaaa aatactttga tttgctaatg tcgccagtag tacgataata ctataaagat 755401 atgctgttga agctgatatt taaagaatga gaatctctaa gggatcatag tctagaatgg 755461 tattctgcaa aacaaatttt aaatggtgaa aacttttcct cactatgtcc aattgatgct 755521 tcttaggatg acgttagaat tttattttag tgcaggcatt accttgctaa gttcattcat 755581 taaagtacta atatacctct tactggcatg catttaccta agtggtctcc gttagccgtg 755641 gtcttttcga acgcaacaac tttcaagtta agtaaaaatg atttattcta taaaatatgt 755701 atgtagtggg aaagactcga cagacctgct tgccaagttc tctttctaag caattgagtt 755761 ggccagtccc cctgaaaatg ctaatgccca tgtgcgactc attccgttat ccaaatatgt 755821 ggatgaatca aaagttgaat cactgaaaaa tgcatacgaa tctactgggt cgaagagtgc 755881 ttgattcagc ttcaatatgc ctgtccagcc gctttctatc gattcaataa ttggctcgat 755941 tttagtctgc cattcttctt cgacgaaagt ctcagaacga atattagaag aaactggtgt 756001 gataggtagc atatgaatac cgtggatata ttctgtgttt gttccaaaat aagtagtata 756061 atcgataata ttatcgaata aaataccact cactttattt cctatgattt cttcaggctc 756121 aactgtgttg tcattttgat aatagaaata gtcgttcatt gcatccttca ttatactaat 756181 catcaagtca cccctcaatt ccattgactg gtcaccgata gtggcccccc ataacttcat 756241 agcataggca aaattgtaat cttcactact actttcttcg ttcttaccgt taccgttttc 756301 ataaagtcca gctgcccatg aatgaccgtt gaaccaatca aacattctcg attgtgcaaa 756361 gtattcatct ttttcagatg gatttgcgac atctcttacc aatgaattga cccaatcttt 756421 attgtcggca gcccaagtac cattcagttt agagtcaaca tagccgatga cagcagctgc 756481 atgaataatg taaccataat ggaaatgatg gtcattgtaa taagtgttac caaaatcgta 756541 ttgcgtgctg gtggaacccc aatctcctga actgaccaaa ccgttgaact ttgtgtcgta 756601 aattagtgga tacgtctgtt cattttgtag cagaatatca aaggccgatt tgatgttttc 756661 caaagtactc ttagtactgg cttcatcttg gatgatttcg gagaccgtta atagaatgta 756721 agaatactta tcgataactt tacccaaata atatgtgttt aacccgctta tactttcgga 756781 aatactaacc tgtaattcgg aattggcaac ttcagctaat aattgcaatt gttctttaga 756841 atactctaaa aggtttgagc caagttgaga agaccatggt aaccaagata tttgtctgtt 756901 tagagatgtg gaaaattgta ggctcgttgt tagataaccg ttcattacac ccttagttgt 756961 agaagcgagt tgaatgccgg tatagtagtc ttgcattata tcactaaatg aagattcatg 757021 atggggcaag gcaaaaatca ttgtgctacc tgatgccgac tcaccttggg tggtataaga 757081 aaattcatag gtagctgtag aaccgtcaga gacaccctgc agcttgaaat tagtaacgta 757141 catacctgcg gcttgatcat aaaagacctc gtaatcagtt tcagaaggtg cgacggccaa 757201 ttgaatgata agaccatcaa cactagcgct tgctttaatt tcatattctg agctcacctc 757261 caatgaaaag tccgttgagg ttaaatcgtc tggtcctatc acgtaacata accaagtgac 757321 tccattcaaa agggtgatac gatatttgag aataccctga gctaaattgc ttgatgattc 757381 agaaacaatg gtattgaatc cgacgctgga accaatcttg gcatttaaag atccatgata 757441 tataccagtt gcaaatccca taccttgaac caaaggtatt tccaggtagt tcgaagaatc 757501 attggattct gatagcacta cccttgttga agacaaggtc atttcatcaa cttgcatagt 757561 catacttgaa tcaaaattcg aagctgagaa aacaacatga gcaattccca aaggattgac 757621 caaatattct gcattaccgg aactgtcata accaccgtag ctatattgat ctactgttgt 757681 atgttgaaca gcaaaaccat atgaactcga ggtgtacttc cacaatgaat aaggatacac 757741 aaaggcaggt gattcctgac taccaacaat caaatttgta taaaacttgt ttgtttgaat 757801 gggaccatcg tttgacaccc catcagccaa tgacatagga tttggtgatc tgtcaaaaac 757861 agttggtggt tcatctgtcg aaacagcatt gaaaagattg acaatggtcg ttgttgaaga 757921 gttctccgtt gtggtagcgg tgctactggt cgaggttgac agagaagagg aggaagtttt 757981 tgtttgtctc gaagatgagg acgaagagat ggtagcttgc attgaagaag atacataaat 758041 ggtatctaat gtcgaagaaa ccggagagga agaagaatct actgttgaaa atagtgatga 758101 caaaagaatg tttcctgttg aactcgatgg ataaactgga ctaacagtcg atgatagtga 758161 tggtgatggt gaagaaccgt tttctgtaat gtttgaaggg taaattggac tagttgtcga 758221 atatagtgat acagatggag aaagagtgat ttgtgtccta ttagatgggt aagcagggct 758281 tgctgttgta gatgcgagcg tctggactaa atcctgggtt gagttggatg gatagaacaa 758341 agtcgaggaa gcaggagttg aagcaatgaa ggaatcttcg ccggtagctg tagctgcatt 758401 tgtccttact gaaatagtat atatcgtttt attcgaggtc aatgaagaag gaataatttt 758461 tgtttcttgg gaagaatagg aaggcatttg agttaccagt ggatcgattg taccttttga 758521 aacagaagtc aataaagttc catttaattg tgtccccgaa atagataaag atgaagaaaa 758581 taaagtcgaa gtcgaagtcg aagcagtttg agataataat gtggtgactt tacgcattgt 758641 tgatgcactt ggcatgactg aggcgacgcc ggaaaccgaa ctcaaattgt gtactgaact 758701 tttgcttttc gaattatcat ttgcgtaaat atttgaaaca gtgacaggat cattattggt 758761 ttgtgcgctt attttttgag atacttggct tgcgtagttt gataacgaca atgacagttg 758821 aactgctgtt cttgtattag aatcactgtc ttgtgaatta attggagatg cgctcactct 758881 attttttggc gaaactgaga gagggctatg agaagctgca gatactcttg ttacaaccac 758941 cgattgtgca acataaggct cacctactgt caaagtagcg taagataaag tttcaattaa 759001 atcagtttcc aatatttcgt ctgcattatt cgatatgaaa cttatatatg aacattcgac 759061 gaaacttaat agaaaaagaa gtgtcagata taattgcata ctagctgttt ttttgttttc 759121 ttttctgtat gcagaccgtt actatggtta tctacttgtt gaaacaagca caagaaacat 759181 acttgatatt catttttgaa acaaattgca ccaagtattt atatgtagtc ctttaccctc 759241 gcttgtagtc ttcgtatggt gtatatgctt tgctactctt ttcataccca gctcttattt 759301 ttaacttttt gggttcagct ttatgattaa ctagtttttc cttggtaacc aaattgggag 759361 atttcgtgcc ttttctgctg gctttcataa caaaatatag ccgaaaagag cttagcgcag 759421 ctgaactcgg taacaaggtt caggtaaaaa ggggagaaaa aaagaaaaga aagccagatc 759481 tttcaaaaat atgccagcaa ataccaaatt ggtcataaaa tagctagcac tccgctatcg 759541 agcaagttct cttggcaagc aggcttattc tattcttttg ctgaaggaaa ggccagttct 759601 atgcttataa ccttaagtag gaaacatatg cgcagcttac agcgcataaa attgatggca 759661 acccatttag tggtactatt cctgcgttat tactagtatg gtcgctttaa agagtggtaa 759721 gatttcacat tttcaaatct aaaaagcaaa gtttatcact tgaaatgtac ctctctgtgg 759781 gctttcacta ccttgtacat tttcttagca gttccgtaca tttttttaaa caatgaaaat 759841 tcaaagttct atgtatagag attatttagg tttttagtac ttaaagtatt ttgagaatac 759901 cttggcaaac gcagaacaat cgtaaaagag attgctactg cgcactgttt ccttgcttta 759961 tcactttcag ttctgcaaga actaaggtgt ttatcagtaa tgatactgta atatcaatag 760021 cgataaaaac ttcgtcagtg aaaccattct ttttaacagc catctatcaa ataaaagagt 760081 ttttaacttg aactgggata tcaatttcag cagatccaac acctttatca aaatgaagtt 760141 ttacgcggag gaaatatgac ctcgagcata aacaactttc aaaacttggc actatggtag 760201 ctttaaaatc atcattatat tttatattca ataacagtgt tctcttatac tcagttgaac 760261 tgacctgatt ccattcattt gatttccgat gtgaaagtac cgaatggtga tagtttgatg 760321 gggaggtttt tttattccta gaagttcgag gaattatgct ggatatagga gaagaagcaa 760381 caggcacact tttctctcca accaacttcg ttttcaacgc atttttcatg acaacaacat 760441 tggcttccat attggctaaa acctgtacgt ccttaattat actcgaaggc attaaatcag 760501 aaaaatcgag cgatctatta cgcaggctag ctcttgcgtc atcggcaaga agtaagttta 760561 tttttgtttg atttttagtg aactcatcgc gatatgcttc aatgttttcc aaaatttcct 760621 taaatatttt cttaatttca ttgtatttgt gcttctttaa aagtaaatca ctgtggaacc 760681 tcactggttt gcaatctttt gtgttcgttg ttaagcaaat caattccgtc tccagactac 760741 tgatttccgg tgggtcatgt ggaatactat tagcagcttg catacatact agttcaagcc 760801 gtaaattttc tagtttttct ctctcttcaa cggacaatag acctcttaaa ttagtccagt 760861 tcttttgatt ctgcctgttt ctcattgaaa atacattttg tttttgaatt agatttggac 760921 accaatatgg caaagcatta ctagggggct ttatttttat tgttataagc ccaattttct 760981 ctgagttagt ctttgaagtg ggatcatctg gttgagatga aggaatatta cgcacacttt 761041 tgagaaacac atttttcaga cctgtgttga agagagatgc tatagagtaa gtaatttcag 761101 tttgaatttt atcttcttca gactagtgtt tctttttaag tgttccgttt tcagtatttc 761161 cagctaccgc gttccattca tacttacctc ttaggggtga tagttgatca gagcgattcg 761221 cctcctgtat gtcctcctta tgaatgggaa tcgctcgctc tattttagaa aagacttttt 761281 cgatcattcc aagcctgttt gcaatttcaa tatcgaaatc ctctaagtct ttgaggcact 761341 tctccctact aattggattg ttttgaaagc caaatggaac tatccttatg ctatactttt 761401 tttcactcat taaacaaaca cgcccagaag ctacgtcttt gcctactatc atagcattta 761461 ttgagtaatt tattaagctg ccactagaac tgtcgtttaa ccatagtgag gaacctcttt 761521 ctgacaaacg accataacct aaactctccg aaaattttag agtagaaagc tctggatgag 761581 aactcgatgg tctatcaaac cctaatgtag ggggcaaaag agagtgagag aagtgaccgt 761641 gcttacaggt tacgtctaat aactggttcg gaattttaaa agtgaaaaat ttcttacgtt 761701 tatcacctgg atttagtatc ctgctattcg gtaatccaaa gcttgtttta tcaatggagt 761761 caaaaaatcc acaaaggtct tcccccgtgt tcacgtcttc atgattatat gaccaactcg 761821 ctgccatatc taccattctc aaaattcttt ctgtcgtttt ttggattcca aagggtgact 761881 gtgtttttga acttgtcgta ccttccaaag ttaaataaaa catatcgaat tttataggtt 761941 tggttgattt gttttctaca gtgaaataac cgtgaattat atccccagag gtgtattccc 762001 ttagcatgct ctcgtgttta ggaagctgtc caaattttgg agccgtcttt gtgacgtaca 762061 attcagtcgc tatgggggtt ttaatcctag gcaatgcgta tatattctca actgggatac 762121 ctttagtatc atcataatta cgaatttgag actcagcagg gccggaagca aaccggcggc 762181 catcaacagt cacttcatga ttatctgggc caacgatatc accggtaaga atccgcatat 762241 cattcccaga ctcaccttcc gaaggaatac tctgatttcg ggaagcaacc tcataaaaag 762301 gtggattctc cggaaagtat gtatcgaaac tagattgagg tatattgctg agcaaatttt 762361 catacatttc gaatgacggc aatagttctg gaaggacaaa gtcatcttcc tgaacattcg 762421 ttatgctcga gcagtgatct ccattattgc atgcgaaagc gtcttcttcc tttccttggg 762481 atgttccaca tctcggttcc tcgaaggagg ttcctccaaa gagtgtggat gaagatgaag 762541 atattctttg acaaccttca aatttatttt gtggttcttt tgattcttgc ataaagaaaa 762601 aacttgatta ttctttagtc ttccagacca gcgaggctat ttagttctat tagattgata 762661 taccaaagcg actatggagc aagttttaca atatctgtat gattggctgt aaatgcaaaa 762721 ctaattgtag taaaccaaca agtgctatgc tctttaatca agggaagcat ttaagaagtg 762781 atgtgatcat attttgtaca attggaattg cttcccttct ataagtgtga attattgttc 762841 atatcttcca aggaaatcat ttaaatggca ttgcttatct actgaacatt tagtaagcaa 762901 aagtgaaatt tctaggggac tgttcgctaa agctgtgcgc ggtctaaaga aagcggtaaa 762961 gatagatagc atctagtcca atgagacgag aaaatatata gatgactcat agaagataaa 763021 gtagtcctaa agaatagtgg tgcatcttct ttaagcctca ctcattctcg cttattcttt 763081 cgtatatttg cacaataggt acgcttgtca ttatgtagat tctcaatact tgatttaagc 763141 agacaataac aatttccaaa cggagacttt tttttccatg acattctaga atttgcacat 763201 tttggcacct ctgaaaagat tgcggatgat agcgtcgttc gcgaatccca ttgattctat 763261 gaagccgcat ccagggtcta aattattgcg cacgtttttc ggtgtggtac acactttagt 763321 caattgtgtt gtaaaaatcg attgttgaag atgccaccta atgtggtcgc tttctcatga 763381 aaattgatgg cgaaggttta acctcccaat tctgttgttt gcagacattc attagaccaa 763441 ggtattactg acgggctata tgcggttagc cggtcattgt agtttcactt ctaaagtgta 763501 cagtaacgtt ttgaaagttt cctttctcaa attgtctatc gtactaacat tgcatcaaca 763561 aatcgtgttc gaaccgccca aactctcact tctgcggtat ggttttttta gcttggtgtc 763621 ataaacttgt ccattagaca agcaaggtca ttgcggattc agctaaatat gggaaataaa 763681 acaaattttt agggctaggg caattgttcc ttgggagcaa aaaattaggg cccggatata 763741 gtcttgcaca agctgtacag ttgcttatat gacggcagac ggtatttatg taagcacctt 763801 agtaaaataa ctttgtatga gacattcctg ggccgtaata tgatagcttt tagcttgtga 763861 atgatggcac ccacatcctg tctaaataat tttaatctcg cacgccgttc tagcttgtgg 763921 tcgtggtttg tcttgttcaa aacgtaaagc aattccctcg cgtaaaagtc ttgataaacg 763981 ccctttcgct gcaaaagacc cacgcttttg ctatttgatt tttcttgata gtttgacaat 764041 tcaataagtt tatagtttga tttatccttt caattttaca cttgttaatg acatactgag 764101 agctcattgg atggaagaaa gcataaacgt aaatcagggt cctgagtgtc tgggtgctgt 764161 ctacgttagt actattcggc tgcattatat tcccaattca caaataaatt aggctcataa 764221 ccgtaatttt attcgagaca tttttggtta cttcaaaata ttgttattat ataaagatca 764281 tataaagttc ttggacaaga ttggatacat ttagttttat ttttgaaaat cacaaagatg 764341 aaacaaaata aaaaatgtca gcgtgccgca ttgaaaggta aaaactaaaa ttaatgaact 764401 tttctaataa agatgaaagg gagaaaacag tatacattgt agcagagcgt ttagaaggag 764461 tactcagaaa gttctaaaaa ggccttattt caaactcatg aagaaaaaaa atttccatga 764521 atgaatgatt gtatgattgt attggcatgt aatatctgca ggatccactc aatcttgaaa 764581 agatactgta gaggaatacc cgaacaacaa ataaatcatg ttacaactct ttgacggcga 764641 agggtgtggc taccgtgctg caacatttta gttactgctg gtacattaaa attgggaaga 764701 tgtccaagag aagaacatgt tctgctatcg aatctctcac gatatatata tatatatatt 764761 tatatgactc acctggtaaa acatctatgt ttcgtttcat atgagggctt aggtaccatt 764821 cttttagagt taagatctct tattgtggaa aaaagaagtt gaacgtgatt tcatttgttt 764881 attgtgctag tggctggaaa tatgaaaact tttgctcttg caacgtacct ttttacttaa 764941 tgtcttatat ttgaacactg ctatcccagc tacacaacgc attttctgaa ggaagagagt 765001 ttagaagaaa cctttctctg tccatcgcta taatcagccg tttctttttc gcttccttac 765061 gaagtaaagg gtgtcccttt ataacgtaag cgtccaaaat gcagttatta atatactcca 765121 ttgcacgcaa agaaatttca aggaaagtat ccgggaattc tgatatttta cacttgcact 765181 aatatactct tattagaagt agtgatggta gacctcaaat caatctaaac ataatggatt 765241 tccatactgt taaagacggc gatacggaat tgaggtgtcc tattcccgac acttttgatg 765301 cgtcagctat aatcaaatct tatgttaaat aagcttctga acaagggatt catcttcgta 765361 aggcaggtgt agccatggaa tgcgtttcag tagaaggttt ggattcttct tttttggagg 765421 gccaaacctt tggcgatatt ttgtgtttac catggacaat tatcaagggt atccgtgagc 765481 ggaagaatcg caataagatg aagatcattt tgaagaatgt cagtttgctg gctaaatcag 765541 gagagatggt ccttgtccta ggaagaccag gcgctggctg tacatcattt ttaaagagcg 765601 ctgctggtga gaccagtcag tttgcaggtg gtgtaacaac aggacatata tcgtacgatg 765661 gtatccctca gaaagaaatg atgcaacatt acaagccaga tgtaatctat aatggtgagc 765721 aagatgttca tttcccacat ttgacagtaa aacaaactct agattttgct atttcctgta 765781 agatgcccgc aaaaagagtc aataatgtaa cgaaagaaga gtatattact gccaatagag 765841 aattctatgc taaaattttt ggtttgacgc atactttcga taccaaagtt ggtaacgatt 765901 tcatcagcgg tgtatctgga ggtgagcgta aacgcgtttc cattgctgaa gcattagcag 765961 cgaaaggttc aatttactgc tgggataatg ctacaagagg tcttgactct tctaccgcgc 766021 tagaatttgc acgagctatt cgtactatga caaatctgtt aggtacaacg gcccttgtta 766081 cggtttacca agccagtgaa aacatttatg aaacttttga taaagtcact gttctatacg 766141 ctggaagaca aatattttgc ggcaaaacta ctgaagcaaa agattatttt gaaaacatgg 766201 gttacttgtg tccaccgaga caatcgactg ctgaatattt gaccgcaatt actgatccta 766261 atggtctgca cgaaataaag cctggctttg agtatcaagt acctcatacc gctgatgaat 766321 tcgaaaaata ctggcttgat tccccagaat atgcccgcct aaaaggtgaa attcagaagt 766381 acaaacatga agtgaatact gaatggacca aaaaaacata caatgagtct atggcacaag 766441 aaaagtcgaa aggtacaaga aaaaaatctt attatacggt ctcttattgg gagcaaatta 766501 gactttgcac tattagaggt tttctaagga tttacggtga taagtcatac accgttatca 766561 acacatgcgc tgctatagca caggctttta tcactgggtc attgttctac caagcacctt 766621 cttcaactct aggggccttt tctagaagtg gcgttctgtt tttttccctc ttatattatt 766681 ctttgatggg tttagctaat attagtttcg agcacaggcc aatattgcaa aaacacaagg 766741 tctattcact atatcatccc tcagctgaag cgttagcaag tacgatttct tcttttccat 766801 tcagaatgat tggtctaaca tttttcataa tcatcctgta cttcttagcc ggtttgcata 766861 gaagcgccgg tgcttttttt actatgtatt tgttattgac aatgtgttca gaagctatta 766921 caagtttgtt tcagatggtt tcatctttat gcgatacatt gtcccaggcc aactccattg 766981 ccggtgttgt gatgttatct attgccatgt attcgacgta catgatacaa ttaccttcaa 767041 tgcatccatg gtttaagtgg atttcgtaca ttctacccat tagatatgca tttgaatcga 767101 tgttaaatgc agaatttcat ggaagacata tggattgtgg tggcactttg gttccttctg 767161 gacctgggtt tgaaaacatc ttgccagaaa atcaagtgtg tgcttttgtt ggttcaaggc 767221 ctggccaatc ttgggtccta ggtgatgatt atttgagggc ccaatatcaa tatgagtaca 767281 aaaatacttg gagaaacttc ggcatcatgt ggtgtttctt aattggctac atcgtcttga 767341 gggcggtttt cactgagtac aaaagtcctg tcaaaagtgg tggtgatgct ctggtcgtca 767401 agaagggcac aaagaatgct atacaaagat catggagcag caaaaatgac gaagagaacc 767461 ttaatgcctc tatagcaaca caggatatga aagagatagc ttcaagtaac gacgatagca 767521 caagtgcaga ctttgaaggt ttggaatcta ccggggtgtt tatttggaaa aatgtttctt 767581 tcacaattcc tcattctagc ggacaacgta aacttctgga cagcgtaagc ggttactgtg 767641 ttcctggtac tttgacagca ttaataggtg agtccggcgc tggtaagacc acattattaa 767701 acactttggc tcaaaggaac gtgggaacga ttactggtga tatgttagtt gatggtctcc 767761 caatggacgc tagtttcaaa aggcgtaccg gttatgttca acagcaagat cttcatgttg 767821 ctgaacttac tgtcaaagaa tcgctacaat ttagtgctcg tatgcgtcgg ccacagtcta 767881 ttcctgacgc tgaaaagatg gaatatgttg aaaaaattat atctattctt gaaatgcagg 767941 agttctcaga agctcttgtc ggcgaaattg gttacggctt gaatgttgaa cagagaaaga 768001 aactatcaat tggcgttgag ctagttggca agccggatct gttattgttt ttggacgaac 768061 cgacctctgg cttggattcc caatccgcgt gggccgtcgt caaaatgtta aaaagattag 768121 ctctagcagg tcaatcaatt ttatgtacta ttcatcaacc atcagctact ctttttgaac 768181 agtttgacag attattgctt ttgggaaaag gcggtcaaac aatttatttt ggtgaaatag 768241 gtaaaaattc aagttctgtc attaagtatt tcgaaaagaa cggagccagg aaatgtcaac 768301 aaaatgaaaa tccggcagag tatattttag aagccatagg agctggggcc accgcttctg 768361 ttcaacagaa ctggcctgat atatggcaaa aatctcacga gtatgcaaac attaacgaaa 768421 aaataaatga catgattaag gacttatctt ctacaacttt gcataaaaca gctacaaggg 768481 cctctaagta tgcaacatcg tattcctacc aattccatca tgtgctgaaa agatccagtt 768541 taacattttg gagaaacttg aactacatca tggccaaaat gatgttattg atgatcagtg 768601 gcttgttcat tggttttacc tttttccatg tgggtgtaaa tgctattgga ttacaaaata 768661 gcttatttgc ctgtttcatg gctatcgtta tatcagctcc tgcaacaaac caaatacagg 768721 agcgtgctac cgttgctaag gagctatatg aagttcgtga gtccaaatct aatatgtttc 768781 attggtcttt acttttgatt acccattatt taaatgaatt gccttaccat ttattgtttt 768841 caacaatttt tttcgtttca tcatatttcc ctctgggtgt ctttaccgaa gcctctaggt 768901 caagtgtttt ttatctgaac tatgccatac tttttcaact ttactatatt ggtcttgctt 768961 taatgattct gtacatgtct ccaaatctac aatctgccaa tgttattgta ggttttatac 769021 tttcgttttt gctctctttc tgcggtgctg tccaacctgc ctctttaatg cctggtttct 769081 ggacattcat gtggaaacta tccccttaca cgtatttttt gcaaaattta gttggattat 769141 tgatgcatga caaacccgta agatgttcaa agaaagagtt gtctcttttc aaccccccgg 769201 taggccaaac atgtggtgaa tttaccaaac cgttttttga atttgggact gggtatattg 769261 caaatccaga tgcaacagca gattgcgcct attgtcagta caaagtaggt gatgaatact 769321 tggcgcgcat aaatgctagc tttagttact tatggagaaa cttcggtttc atttaggctt 769381 atatcctttt caacattgcc ggtatgattg tggtttatta cgttgttcaa gttaagcatt 769441 tttcccctat gaaaattggc ttcgtaaaaa gaataacaag taaatttaag agaaaatgaa 769501 gaaaaaaatt gcaggtatac tatgggtgca ggtgaggcgg ttttttaacc gatttagcac 769561 acgatactgt gaattttggg ttatatgatg atgtgaatat tgcagaaatg taatgttata 769621 ttattcaaag aaatagggta acttctattt atgcaaacat tggtaatcaa ggctataaac 769681 acataatccc aaataagtat tttggtacac agttgatgtt tctttatgaa tacgactcat 769741 tagttcactg tcaaattgcc aacgttcaga gggacctact tacagagcgt atgttttata 769801 tttacgacga acgcgatcta attattatcc gctggttaaa cagcgtaata atgttcatag 769861 gggccttgca tgacatttga atttgaacat tactagagtt cgtgaaattt tgtcaatgaa 769921 aaaataatgt gacaaacgtc tgcaaataac ctgaagaatt ttatccggga taacgacaaa 769981 gcgttaaata tagaaacata gtgaatgtac tgctaggaaa aaaataggca taatttaatc 770041 tttattcata taaatgtttt taccagaact ctcttggtag atagttttga tatacggttt 770101 cctgctcaat tttagtgagg ctgggacgta aagtattttt ttcaaataaa ccatttcttg 770161 tttctacctt tttagtacgg atttttttta gtaagttctg tattcttttt taagagtaaa 770221 aaatattcag accccaaact cacaaaaagc ctacagagtc cgcctgttac gctcaattta 770281 gtactaccac ttgtgataat atttattttg ggacaggtcc aaaaactttt aggtttaaac 770341 gtacaaacgt tgagtttaat ctagatcata tatcattata aaggttttat ctacaagcaa 770401 gtgaagaaac gtaacaaacg taaaaagctt cagcctcacc taaatatcga atttgtactg 770461 agtctttgaa gtgtatacct cgccgcgctt cagaagaaca caacctctcc actcatcacg 770521 gttgatagca tcaacgtatc taccttgctg aacggcaaat ccagaccttg gcacaaattt 770581 gccacataaa ttatcaccgg tgtacaaatg aacggttggt tctgtcgtcg aaacctcaaa 770641 tttgatgtga gattcgggat gataggcctt aaaaacagga accaatttgt tgacactcac 770701 agaatctgta gtcttcaaat ccttgttagc gtcaataatg aaagtgcaat caaagaccgg 770761 agtatcttca tgcaaaacgg tgggcttagt tgaatcaaaa gtagcaatgt tcctttcaat 770821 gatcttacca gttggaagca atgccccctc tgtaacttca agcgatttgt tcgagcagac 770881 cttaacttct gtaccacgaa tggacttctc actcttgact ttgttcaagt taaaatacga 770941 gtggttggtc atattaattg gagtagcatc accacgaact aactgtgctt ggtattccat 771001 gtctaaagtc atttctgcaa cattcaaagt gtacttcact gtgacttcca agtcacctgg 771061 aaactcgtta gggttgggct gtgtgtgatc atccaacaat ttaaattcaa caacgtaaac 771121 gcccttggaa ggattctcaa caggggacgc cttgtactgc ttaagattta aggaactgat 771181 actgctgtga tttgtgttac cacaattgtt aacagttaac ttgtgaggac catcatccag 771241 gctgaaaaca cccttggcga tacggttggc ataacgacca actgtagcgc ccatcatgtt 771301 accatctgtt aaatagtctt gtacgtttga ataaccttga acgactgatt ggccgtttac 771361 cttcaggtct accaaagttg caccaagtgg cgcaatggta gcttggaact ttttctcatc 771421 accaattgta atgacaccat acttattatc accgttacta tttgacattt cgctgtttgt 771481 tatctgtttt gatttttttt ttcactgctt atcatacaaa ctgatcaatt gagctatcaa 771541 acttcaactt atctctgtat ttatatgctg aaagtataga gtgtacataa aaatgtatca 771601 catgtctatt acatattacg acacccccac aatattttaa ctgatcttaa taacacgggg 771661 taggaagttt atttcatcat accactcaat gagctaagct gccaaaggct cctgttcact 771721 tccttgtggt tcgtaggcta ttcagtggca acgtaataaa caagaaaaga aaaaatttca 771781 acacctttat tctaaatgtt gtcagaagta attatagtgg gggtattgca gatgtaaatg 771841 aaatacgacg tactgtgggg ggcttttctt tttcaagaat cctaaactat tccaatggga 771901 ttgcgtgatt atgtttcgtt agagtttttt tctatatctc cgttcttatt tcttaagtcc 771961 gccccttgct gtaaccagcc cggctattat ttgacgaatt tttcacatct tcattccttg 772021 ccgagaaaga agcttttgcc tccctggggt tattataaaa tatatctgac gtcactggtt 772081 tgcagccaaa aagtttaatt attttaactt caagggttcg tttcggagta aatagtcaat 772141 gcacaaaata ggaaggtgga ggtggggtat gcatttttgt gcatagagtg gcggggtatt 772201 aagaataatg cacatatagg cacataggca caaatgcgtg ggatgacttg actgtgcaaa 772261 gaccgttagc aacctagaat gtggaatagt atcccaaatg atgacgtaaa cgttcgagga 772321 taatattaga taatataata ttagtatcct cgtctaaaaa caggcaaaat agcacggaat 772381 ctattcaaaa gaaggcggca agcagtatca attgagataa gtgtatacga acggtgaaac 772441 ctccttggca cagaatttta tcgttcaagt ggtaggatag cattgctgcc ataacaccct 772501 ccttaatcac aggataatat ggtgaacgag atatataaag cgataagttt aggtgtgata 772561 tttttctttc gttgtgcaag tgttgtgtaa attctttctc atttgataaa tcaaaaaaaa 772621 aaaaaaaaaa aagaaaagaa aagaaaaatt aataaaatgc aatcatccac tgaaagtgat 772681 agagatattc aggatggtcc tgatgctgat attcacgtcg caccacccgt ggaaaaagag 772741 tggtcagatg gatttgatga caacgaagtc ataaacgggg ataacgttga gccaccaaaa 772801 agagggctca taggttatct tgtcatttac ttattgtgtt atccaatatc cttcgggggt 772861 ttcctgcctg gttgggatag tggtatcaca gcaggtttca ttaacatgga caactttaaa 772921 atgaacttcg gttcttacaa gcatagcact ggtgaatatt atttgagcaa cgtgcgtatg 772981 ggtcttcttg tggctatgtt cagtattgga tgtgccatag gtggtcttat ttttgcccgt 773041 cttgctgata ctttaggtag aaggctggca attgtaatcg tggtgttggt atatatggtt 773101 ggtgcaatta ttcagatcag ttcgaatcac aaatggtacc aatacttcgt tggtaagatt 773161 atctatggtc ttggtgctgg tggctgttcg gtgttgtgtc caatgctttt gtctgaaata 773221 gctcctacag atttgagagg tggacttgtc tcattgtacc aacttaacat gaccttcggt 773281 attttcttgg gttattgtag cgtttatggt acgagaaaat acgataacac tgcacaatgg 773341 agagtcccac ttgggctttg ctttttatgg actttgatta tcatcattgg tatgttattg 773401 gttccagagt ccccaagata tcttattgaa tgtgagagac acgaagaggc ccgtgcttcc 773461 attgccaaaa tcaacaaggt ttcaccagag gatccatggg tactcaaaca ggctgatgaa 773521 atcaacgccg gtgtccttgc ccaaagagaa ctaggagaag cttcatggaa agaacttttc 773581 tccgtcaaaa ctaaagtcct tcaacgtttg atcacaggta ttcttgtgca aacctttttg 773641 caacttactg gtgaaaacta ctttttcttc tacggaacta ccattttcaa atcagtcggt 773701 cttactgatg ggtttgagac gtcgatcgtt ctaggtacag tgaacttctt ttccactatt 773761 attgctgtta tggtcgtaga caaaattggc cgtcgtaaat gtcttttatt tggtgcagct 773821 gggatgatgg cttgtatggt catatttgca agtatcgggg tgaaatgtct ttaccctcat 773881 ggccaggatg gtccatcctc aaaaggtgca ggtaatgcca tgattgtgtt cacttgcttc 773941 tatatatttt gctttgcaac gacatgggct cctgttgctt atattgtggt tgccgagtcg 774001 ttcccttcga aggtcaaatc tagggccatg tcgatttcga ctgcatgcaa ctggttgtgg 774061 caatttttga tcgggttttt cacaccattc attactgggt ctatccactt ctattatggt 774121 tatgtgttcg taggttgttt ggttgcaatg tttctgtacg ttttcttctt tttaccagaa 774181 acgattggtc tatctttgga ggaaatccaa ttactatatg aagaaggtat aaaaccatgg 774241 aaatctgcat cttgggtccc accttctagg agaggtattc cttccgaaga aagtaagacc 774301 gagaagaagg attggaagaa atttttgaag ttctcaaagg gttctgattg atcatagagt 774361 gcatatgctt gtcttgatag gcaacattgt atattatatt ttacataata atgtgtaatt 774421 ctaatttgtc acgaatttat gaagattctt ggagctatga agatcaacat atgtagaaac 774481 tggtatgtgt cataggtaaa aagtattcat taagacaaaa ttgtgtctaa ttcttagtca 774541 tttattcaat tttttttttt tttttttacg taaagcgggg tggagtgaca tgatatggtg 774601 atggtgatga gaaactctaa atggatccat ttgactatcg attgaaaatc atgaaagatg 774661 cgcttgaagg aacataacac gttactattt gtctaaataa aacaatatac aaaaatacga 774721 cattatatat actctaccca agatatttag tcattactat cgagggcgcg tagatcagat 774781 cacctttaaa atcacacttg gtctaaaatt tccttaatag cggcaattgg ccctttatca 774841 taaactgttt ctagggagtg ggtcaactgt gcaacgaatt ctttgttgtc acgaatctca 774901 ggactgaaaa gcacctcaat gttgagcagt tcgtgaggat ctttaccacc cttaactgcg 774961 gctgccttca aggttggtgc cataggatcc tcgatttcga atggcttccc attcatgtct 775021 acaccagtca ggtaacggaa ccagccagca acacatactg ccaataactt gtacttacca 775081 tctggtttac gcaattgctc gtaaattgat ggcaaaacat acttaggcat cttaccagag 775141 cccatcaaac aaatacgtgc gacagtgtcc tgaatagctg gattggagaa tctttccaac 775201 actgatgcag tgtactcttc gaaatcaaca cctggcactt taggcaataa tgggataact 775261 tcctcacgca tcaaaacacg gatatacttg ttgatagttg ggtcgttgac aacctcatgt 775321 atataggtgt agcctgccaa gtatcccaaa tatcccatag cagaatgtcc accgttaagt 775381 agacgcaact tcatcaattc gtaggaatcg acatccttga cgacctgaac accaacaagt 775441 tcccatggag gacggccatc ggagaagttg tcttcaagaa cccattggat gaaaggttct 775501 gcgacaacgg gacattgatc cttgattccc caggtgtcag caacgtattt acgctcttta 775561 tcggtacaac gtggggtcac acggtccacc atgctgttag gagaagtaac cttgtcttca 775621 atccaggcgg cgaatttctc atccttcttt aacttggcaa atgcaacaag catggtcttt 775681 actgtgacac cattttgggg catgttgtca catgacataa tagtgaatgg ggtaagacct 775741 ctcttgtaac gcaacaacag ggcctcatat agatacccat acagagtatc tggcttttct 775801 gggtggttca aatcattgat aatctcggga gcatctgtca ttaaggagtt tgttgcttca 775861 ctgtggtagt aaccgttttc tgtgaccgtc aaagaaacaa tgtgtgtgtc tggattggcc 775921 atcttttcaa taacagctct tggatcatcg ggagcgtaca tgtaagcagt aatagaaccg 775981 acgatataag cgttagtgtc cttgatacca cgctccacaa gggtgtatag gcaatcttgg 776041 gccttcatgg catcgcgcat aagtgcatct gctttcatta aaccaacacc acatatggac 776101 caatccttta agtggtgctc ctgcatcaga cggtgcatga aaacagctaa atgggaacgg 776161 tggaatgcac cgactcccag atgaacaata ccttgtttaa caccttctct tggataagtt 776221 ggtattggaa gagtggattc aaaactcttt agagttttgg cattcaagct ggtagctgtt 776281 gtttcgtctg attttgtcat attttttttt ttgtttaaat tgttactttt tctttttagt 776341 tttctctgat tatttttgtt tatttttatt ggagttatac ggaaagatct agacgaagtg 776401 gaaatcttaa caattggata ataaatgttc gctatttata tgcaaaaaat gaatgaattt 776461 tgaactatga gtctgcaacc actgtaacct ccttcctcct agaatatgat tgtttcgaac 776521 ttatttggaa acgctaaaag tgattcttga ttatttctag actttgcgat gccctctccg 776581 accaccacag cagaatatac gaggtatccg tccatatatc caccactgat gcgcaagctt 776641 aattggttca cgtccgcacg aaaagtttat aaaatgacgt atcatggggg ggagtgttga 776701 atcaaaaaag tggcgagcta aaaataaaag aaaagtgtac gtggaatgaa ctgtttgctg 776761 agctcatcct acggtcattt tagcccgtgc caagggaaag tgactatacg gtggggtatc 776821 gcggggtaag gagactcagg tacaaaggca aaaatcaaga taggcacata agaaggcacg 776881 aaactacccc acgtttcaag ttttgctata tcccttattt attgcgcgcc ctgcaggaaa 776941 ataagtttta ggcacttaaa aaataaagtt cccggggtca atttctggta gtggcaagca 777001 aagtatactg aagttggcaa gcaacacgta gcctctgcat atatcggcct ttctcggaat 777061 gaaataatca aaaaaatatt atgcgggaag ccgctgtttt attgagcatt ctaatgcttt 777121 ctttttccca gcacctaaac cacacaatac tttactccag ttccgtattt gcccctccca 777181 tggcatcacg cctatacctt aactgttaat tctcaccgtc cccattatac taggtttaaa 777241 aaagaaggtg gtcaatcctg ttgatatctg tatctctata taacaaaact tcggtataaa 777301 acattcacac ttcgagtaaa atcagtacct atcttcatgg accctccaaa atgtcaaatt 777361 gttatcaagc gattgataac tctaatgcac aggtgtaata ccgttttact actgtcaaag 777421 aaactacata tagtgtgaga atccaaagct aacattttcg agtaacttcg ggttttaata 777481 gattattatc tgaatgcgaa gttcaacatt tgttgtttcc agcggccttc tttgtttcac 777541 aatacagaaa ctaatatata tatatatata tatatatata cgctgcagtt catattttag 777601 tctatttttt gaataaaggt tccattttgt cggagaaaag attcttcgac tttgctctag 777661 aaattaaaaa cgatggaata ttaatcgtcc caagtaacgg tagtggaaat tggccaaacc 777721 ctgcatttgg cccaagggag acaccacttg gggcatgtcc tgtctcaaga caatctgcat 777781 caacgagact agcctctgtt ccttcttgta aagaacttat aacatttcgg gtcaaaacat 777841 caacccaatt atctctttta accaatccgt gatatctaaa attcgttaca tcaccaatgg 777901 caaaaacgtt tcctgcctca acagctttta ccctgaagtt tttttcaact tgaatgaacc 777961 ctttcttgtc acaaaggtct gaaatactgt tgaccggcac atttggagaa ataccaacgc 778021 ctctgtaaat caaatcagca tctatatatt tagatgagcc ctcacctaga aaaatacgtt 778081 tcggcgaggt gtctaaagaa gcccctactg tgttcaagta caacgtaata ccattttttg 778141 agagatagtc tgtcacattt tttcttaggg tatcgttgta taacccagag tccggcagta 778201 gcttatcgga attatgaata atggaaatac gctttttgcc agacctgatc tcctccaaat 778261 acttgaataa caattcacca gctagttcac aattaacaaa gccaccgcca agaaaaagta 778321 tgtgatctgc atctgagatt cgagaagcct ctctttcaaa atactcttta tagttatccc 778381 cgaaggtata agttgaacca attggatcag cccactttga gccagttgca agaaccaaga 778441 tatcaaactt tatggccctg tctgacccca aaactacctc cttatcatca aagctggcag 778501 ccgtatcttt gataacttca ataccactat caagaacatt ttttaacggc aggatcgact 778561 tggtataatc ctttgaaacc gtcaaacgga cagctgaggg tagaaaatac acataattag 778621 atgctgtgac gagctttatt gcgtatgtcc cacccagttc cctgtacaag tgatttgcca 778681 cagacacacc aaacacacca gcaccaacaa caactatgtt ctttgtgtta attgtcatat 778741 attttgcaat ttctttcttc ctttctctgc tctttcctgt aaataatgaa gaacaacgat 778801 gaggaaatgt gtgtctatca atgatttatc actgctttcg tttctagtct gcagcagcta 778861 atatattaat acttataata ggcttcattt gtccagccag ataaaaagga ctaatcatgc 778921 agggtggaca ttcaattaat ttttatcgct ttttaacgat tactaatcca gtattaccaa 778981 ctacaatcac tcagtcatgt atcactaata acgaaaagta agctgtacaa tgctcatctt 779041 cctagcacta ctagtactgc tactatgaga caccattgaa gtcttcttca agacccccat 779101 tatgagaaca cttggctcac tatacaatcg gcgggagatg ggttgttatt atagagagtt 779161 tcaggaaaag cactcctaga ttctagtcaa gtactgccta ttgtataaga gacgagggca 779221 cgagatagcg cagtatttta tgatgaaaat atgaaaataa atacttaact cattgagtaa 779281 gcttagctgg gcaacttaac taacagtcaa aaaaaaaaaa aaaaaaaaaa aacaagagcc 779341 agcaaactga cattaacatt gatcaataaa ataagaaaaa atgtaccaga gaattcgatt 779401 atgaactgat gacaatatca ttaaagactt tgcacagtat tcaaaaacta atcgagagct 779461 ttgaccaaaa agtgtcccga ctttataatg agaccgccgc ttaattcata ggagttatat 779521 ggtatgcttt ggaaagctat tacattgttt gataattcaa aaataagcca caatacttca 779581 cctattgtgt accatgtatt ataaaacatc gcagctcgta tctgtaaaca tacattgact 779641 tacattttag tgataacttg ggtacttgag tgaagtccat ttctcccgtg cttccggaac 779701 ataaaccaac atagattctc tttcactcga aactgctcga agctgttgct ctttttttga 779761 tcgtggcttt aactataaaa ctcaacagct gcgtgatgaa cgcgctgtca acaaatttca 779821 tcttgcgaat tatataaaaa acactgcgag tgattaaacc tcagtaaact tgttacgtac 779881 ctcataacat taatgtgaaa tacactatat tgaatatggg ggaagagatt agacttttgt 779941 cctctaaagg tcttgagacc catagtagct tttgtttgcc cgaggatatt ttcagaaacc 780001 gtttaacatg gttgtgcagt gagattcgca actcaggatt ttggatctgg tcgctatcat 780061 ggttaccgct tgccgtttgg tgggggatgg ccagtacttg gttttatccc cttctgactt 780121 cagtagttct aatcctggcg ctaattgcta ttttgccagt agttcaaata cagtacagta 780181 aatatacttt atcaaatcaa ctcacccagc tttctaaaga aatcatcaaa agtgcaccag 780241 gtgcatactc tgctgattgg gacgctgttg caatacattt caattcctac ttgtatgaaa 780301 acaaagcatg gaaaactgca catttttttt ttaatggtac tgactgccaa gaagcattca 780361 ggaaaaccat tctagagcca gctgttttga ggagacaaaa cgaagatcct aggttcagtt 780421 caattgagat tttggtccct tacaccgaag acgcggtgca ggtttatttt acaaaagtaa 780481 acgcacagtg gaggttgatc catggtaaga aggaatgcaa acttactatg ttggaaaatg 780541 tcaagcttcc taaggaaacc tatcgctgca agctagcatg gagttgccag agaatcagga 780601 tttctttctc tccactagac ttccttcctg atatgtctga cttctttatt tgtgcaaatt 780661 tatcaccagc atgcttggta tcttattggc taatagacat tttctttaga atgatagatg 780721 attttcaaaa cataaggcct aaatcgatga aagttgatga taaaatgcag tacctatcag 780781 atattataaa cgagcagggt gctagccctg aaaaatggga tacaattgca aggaaaacga 780841 atacacgatt atttgaaaag agggtctgga aaaacgaaga gtttttcttt gatgggactg 780901 attgtcaggc attctttgaa cggaacttta gtagcctttt gttctcaaaa aaatctgcgt 780961 cgcctagatc attaaacgtt gaactttgga aatacattca agaagcgcaa ttgagctgta 781021 actatgagcc gttaccataa agatagaaac atttattttg acttagaagc tacaaggagg 781081 atcaactatt aatatttttc ctagagaaca tttttaaaat tggattcaat aaattagcgc 781141 catctattgc ccttacactt ttctccttca tatctggcta gaaaaggggg ggttacatct 781201 cggaatcaaa tattttcctc tgcgtcgagt tttaatcctg cttctggtta cattcttttt 781261 tatcatacac gattctttga acatcaactt ctctcaaaac catccgcctt cagcggctac 781321 aattacgtaa ttgcaccaag gcattcgcgg agaattcacg aatttgcaga cgccaacagt 781381 atacgactcc caacacacgt ctaatatctt gtacggattt caagagatag aaatattact 781441 tccatggaag ccgtttagag cagactgaat atgggcttag acaataagct tctgaacgag 781501 ggtcttaaat ctaaattcgg attttctttt tgaccgaaag cggaaacttc gcaggcgcgc 781561 aaaaggggtt ttcaaggcac ctcggcaccc ctataattgg cattctcaca ttctgcgcat 781621 acgaatacac atgagtgcca taaaacagta ctccacatac gaagtctatc aaagatgtat 781681 gattcgttca aaaacaagaa catcttcata gtgataatga gattgtgtga aagatgagat 781741 atggagaata tgtgaggtgc taaatgagca tctgttaacg aatcgtttaa gtagtgataa 781801 cagatggagg aacgggtata aatagagctg cttcaactat atgcctttga ggtatgcgct 781861 ttcatttcac tatttcttgt taagattaca tcagcactaa caaacaaaac aaatacaatg 781921 gtcaaattaa cttcaatcgc tgctggtgtt gccgccatcg ctgctactgc ttccgcaacc 781981 accactctag ctcaatctga cgaaagagtc aacttggttg aattgggtgt ctacgtctct 782041 gatatcagag ctcacttggc ccaatactac atgttccaag ccgcccaccc aactgaaacc 782101 tacccagtcg aagttgctga agccgttttc aactacggtg acttcaccac catgttgact 782161 ggtattgccc cagaccaagt gaccagaatg ataaccggtg tcccatggta ctccaccaga 782221 ttaaagccag ctatctccaa ggctctatcc aaggacggta tctacactat cgcaaactag 782281 ggagtgatgc ctttacgaat gaaaatccat agacagtgaa aagtaatgaa aaaataaaat 782341 aaaaaactac tttttttgat gatataaata ccgttgatta tataaatgta tattaatatt 782401 atagacctat ttgatcaatg acggtgttcg tgaagtattt catgaatacg ataaacataa 782461 gaaagaaact tttacactat tgtagaaaaa gcgtggacgg aaataaagct aacagagtat 782521 gcccaataaa caacaatgaa attggaagcg tatgacttcg cagcactttg tccttccata 782581 aaaatgagtc gctgcttctt ttttcatttt ttggcgcgtc gcgtcgggcc gtatagaata 782641 tgcgtcactt ctaagaacaa gattgcagat cagggcagtg cgagttacaa gtcatggtac 782701 cagactctca tttagagacc ctcatttttg acacttaaaa tatcaaaatt tctgggttgc 782761 gatagttttt gtgtaactgt aactagaaat aaagctgagg ggttagtgtt ttatcaacaa 782821 taagatagag ggtggtaaga tgaagtgaga caatatcgta acgtccgttt tagtatacgg 782881 cgctgataag ttatattacc gtagaattat ttggcgtttc gttgactcct acaaaaacaa 782941 caaacctatc accgtatcgt cttctttaga tatagtctct tcgtatgagt agtgtcacat 783001 acaagattaa agatgcatca gttatccttt taggatattg cggttagcat atgggaatgg 783061 aaataggata caattttatc atagcaccgg catgagtttg agccactacc gtattgtttc 783121 tcggtgaata tagagtgtta cgacagtgag gtggcatatt attctaatgt atggtctgtg 783181 aaagttagaa atattctgaa atggcatccg ttcaagcaaa tggtaatatt aaggaacttt 783241 tacgttaatg acgttatggt agtgctcata cttcaagtca atatgtttat ttcgtaaagt 783301 tgaaagataa ataattttta tgtttaggtg attttggtgg tgattttgtg ggtatattga 783361 aataagtgtg tataaattga gtggttagta tatggtgcaa aagtggtata acgtatgtat 783421 taagagcagt tatacaatat ttggggccgc cgaatgagat atagatatta aaatgtggat 783481 aatcgtggga gttatgggta aatggctcag ggtatagacc gctgaggcaa gtgccgtgca 783541 taatgatgtg ggtgcattta gtactgattt agtgagagat gggtcatgga gtggagtgca 783601 atatgagagt agggtaagtt gagatggtat atactgtagc attcgtgtgc gtatgcccca 783661 tcaatataag tgaaggtgag tatggcatgt ggtggtggga ttagagtggt agggtaagta 783721 tatgtgtatt atttacgatc atttgttaac gtttcaatat ggtgggtgaa caacagtata 783781 gtgagtagca gatgggggat ggtagggtaa tggcagggta agtggtagtg gggttggata 783841 tgggtaattg gagggtaacg gttatggtgg gcggtggtta gtggtaagta gagagatgga 783901 tggtggttgg agttgtagaa tggaatggaa cagggtaacg agtggggagg tagggtaatg 783961 gagggtacgt taagagacag gtttatcagg gttggattag aatagggtta gggtagtgtt 784021 agggtagtgt tagggtagtg tgtgggtgtg gtgtgtgtgg gtgtgtgggt gtgggtgtgt 784081 gggtgtgggt gtggtgtgtg ggtgtggtgt gtgggtgtgg tgtgggtgtg gtgtgtgggt 784141 gtgtgtgggt gtggtgtggg tgtggtgtgg tgtgtgggtg tgggtgtggg tgtggtgtgt 784201 gtgggtgtgg tgtgggtgtg tgggtgtggg tgtggtgtgt ggtgtgtgtg tgggtgtggg 784261 tgtgggtgtg gtgtgtgggt gtgggtgtgg tgtgtgggtg tggtgtgtgg gtgtgtgtgg 784321 gtgtggtgtg ggt //