LOCUS BK006943 745751 bp DNA linear PLN 26-FEB-2025 DEFINITION TPA_inf: Saccharomyces cerevisiae S288C chromosome X, complete sequence. ACCESSION BK006943 VERSION BK006943.2 DBLINK BioProject: PRJNA43747 KEYWORDS Third Party Data; TPA; TPA:inferential. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. REFERENCE 1 (bases 1 to 745751) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 2 (bases 1 to 745751) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (bases 1 to 745751) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 4 (bases 1 to 745751) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REFERENCE 5 (bases 1 to 745751) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (bases 1 to 745751) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter COMMENT THIRD PARTY DATABASE: This TPA record uses data from DDBJ/EMBL/GenBank entries AY260881.1, GU570596.1, Z49276.1, Z49277.1, Z49278.1, Z49279.1, Z49280.1, Z49281.1, Z49282.1, Z49284.1, Z49285.1, Z49286.1, Z49287.1, Z49288.1, Z49289.1, Z49291.1, Z49292.1, Z49294.1, Z49295.1, Z49296.1, Z49298.1, Z49299.1, Z49300.1, Z49301.1, Z49302.1, Z49303.1, Z49304.1, Z49305.1, Z49307.1, Z49308.1, Z49309.1, Z49310.1, Z49311.1, Z49312.1, Z49313.1, Z49314.1, Z49316.1, Z49317.1, Z49318.1, Z49319.1, Z49320.1, Z49321.1, Z49322.1, Z49323.1, Z49324.1, Z49325.1, Z49326.1, Z49327.1, Z49328.1, Z49329.1, Z49330.1, Z49331.1, Z49332.1, Z49333.1, Z49334.1, Z49335.1, Z49336.1, Z49337.1, Z49338.1, Z49340.1, Z49342.1, Z49343.1, Z49344.1, Z49345.1, Z49346.1, Z49347.1, Z49348.1, Z49349.1, Z49351.1, Z49352.1, Z49353.1, Z49354.1, Z49355.1, Z49356.1, Z49357.1, Z49358.1, Z49359.1, Z49362.1, Z49363.1, Z49364.1, Z49365.1, Z49366.1, Z49367.1, Z49368.1, Z49369.1, Z49370.1, Z49371.1, Z49372.1, Z49373.1, Z49374.1, Z49375.1, Z49376.1, Z49377.1, Z49378.1, Z49379.1, Z49380.1, Z49381.1, Z49383.1, Z49384.1, Z49385.1, Z49386.1, Z49387.1, Z49389.1, Z49390.1, Z49391.1, Z49392.1, Z49394.1, Z49396.1, Z49397.1, Z49398.1, Z49399.1, Z49400.1, Z49401.1, Z49402.1, Z49403.1, Z49404.1, Z49405.1, Z49406.1, Z49407.1, Z49408.1, Z49410.1, Z49411.1, Z49412.1, Z49413.1, Z49414.1, Z49415.1, Z49417.1, Z49418.1, Z49419.1, Z49420.1, Z49421.1, Z49422.1, Z49423.1, Z49425.1, Z49427.1, Z49428.1, Z49429.1, Z49430.1, Z49431.1, Z49432.1, Z49433.1, Z49434.1, Z49435.1, Z49436.1, Z49437.1, Z49438.1, Z49439.1, Z49440.1, Z49441.1, Z49442.1, Z49444.1, Z49445.1, Z49446.1, Z49447.1, Z49448.1, Z49449.1, Z49451.1, Z49452.1, Z49453.1, Z49454.1, Z49455.1, Z49457.1, Z49458.1, Z49459.1, Z49460.1, Z49461.1, Z49462.1, Z49464.1, Z49465.1, Z49466.1, Z49467.1, Z49468.1, Z49470.1, Z49471.1, Z49472.1, Z49473.1, Z49474.1, Z49475.1, Z49476.1, Z49478.1, Z49479.1, Z49480.1, Z49481.1, Z49482.1, Z49483.1, Z49484.1, Z49486.1, Z49487.1, Z49488.1, Z49489.1, Z49490.1, Z49491.1, Z49492.1, Z49493.1, Z49494.1, Z49496.1, Z49497.1, Z49498.1, Z49500.1, Z49501.1, Z49502.1, Z49503.1, Z49504.1, Z49505.1, Z49506.1, Z49507.1, Z49508.1, Z49509.1, Z49510.1, Z49511.1, Z49512.1, Z49513.1, Z49514.1, Z49515.1, Z49516.1, Z49517.1, Z49519.1, Z49521.1, Z49522.1, Z49524.1, Z49525.1, Z49526.1, Z49528.1, Z49530.1, Z49531.1, Z49532.1, Z49533.1, Z49534.1, Z49535.1, Z49536.1, Z49538.1, Z49540.1, Z49541.1, Z49542.1, Z49543.1, Z49544.1, Z49545.1, Z49546.1, Z49547.1, Z49548.1, Z49549.1, Z49550.1, Z49551.1, Z49552.1, Z49553.1, Z49554.1, Z49555.1, Z49556.1, Z49557.1, Z49558.1, Z49559.1, Z49560.1, Z49561.1, Z49562.1, Z49563.1, Z49564.1, Z49565.1, Z49566.1, Z49567.1, Z49568.1, Z49569.1, Z49570.1, Z49572.1, Z49573.1, Z49574.1, Z49575.1, Z49576.1, Z49577.1, Z49578.1, Z49581.1, Z49583.1, Z49584.1, Z49585.1, Z49586.1, Z49589.1, Z49590.1, Z49591.1, Z49592.1, Z49593.1, Z49594.1, Z49595.1, Z49596.1, Z49597.1, Z49598.1, Z49599.1, Z49600.1, Z49601.1, Z49602.1, Z49603.1, Z49604.1, Z49605.1, Z49606.1, Z49607.1, Z49608.1, Z49609.1, Z49610.1, Z49611.1, Z49612.1, Z49613.1, Z49615.1, Z49616.1, Z49617.1, Z49618.1, Z49619.1, Z49620.1, Z49621.1, Z49622.1, Z49623.1, Z49624.1, Z49625.1, Z49626.1, Z49627.1, Z49629.1, Z49630.1, Z49631.1, Z49632.1, Z49633.1, Z49634.1, Z49635.1, Z49636.1, Z49637.1, Z49638.1, Z49639.1, Z49640.1, Z49641.1, Z49642.1, Z49643.1, Z49644.1, Z49645.1, Z49646.1, Z49648.1, Z49649.1, Z49650.1, Z49651.1, Z49652.1, Z49653.1, Z49654.1, Z49655.1, Z49656.1, Z49657.1, Z49658.1, Z49659.1, Z49660.1, Z49661.1 and Z49662.1 On Apr 18, 2011 this sequence version replaced BK006943.1. ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..745751 /organism="Saccharomyces cerevisiae S288C" /mol_type="genomic DNA" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" telomere complement(1..7767) /note="TEL10L; Telomeric region on the left arm of Chromosome X; composed of an X element core sequence, X element combinatorial repeats, a long Y' element, and a short terminal stretch of telomeric repeats" /db_xref="SGD:S000028901" rep_origin 65..577 /note="ARS1001; Autonomously Replicating Sequence" /db_xref="SGD:S000028438" gene complement(466..6130) /locus_tag="YJL225C" mRNA complement(join(466..4581,4970..6130)) /locus_tag="YJL225C" /product="Y' element ATP-dependent helicase" CDS complement(join(466..4581,4970..6130)) /locus_tag="YJL225C" /EC_number="3.6.4.12" /note="Putative Y' element ATP-dependent helicase" /codon_start=1 /product="Y' element ATP-dependent helicase" /protein_id="DAA08589.1" /db_xref="SGD:S000003760" /translation="MKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFESIPTEVR SFYEDEKSGLIKVVKFRTGAMDRKRSFEKVVISVMVGKNVKKFLTFVEDEPDFQGGPI PSKYLIPKKINLMVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLERCHEIA SARPNDSSTMRTFTDFVSGAPIVRSLQKSTIRKYGYNLAPYMFLLLHVDELSIFSAYQ ASLPGEKKVDTERLKRDLCPRKPIEIKYFSQICNDMMNKKDRLGDILHIILRACALNF GAGPRGGAGDEEDRSITNEEPIIPSVDEHGLKVCKLRSPNTPRRLRKTLDAVKALLVS SCACTARDLDIFDDNNGVAMWKWIKILYHEVAQETTLKDSYRITLVPSSDGISLLAFA GPQRNVYVDDTTRRIQLYTDYNKNGSSEPRLKTLDGLTSDYVFYFVTVLRQMQICALG NSYDAFNHDPWMDVVGFEDPNQVTNRDISRIVLYSYMFLNTAKGCLVEYATFRQYMRE LPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESATSELMANHSVQTGRNIYGVD SFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSNHHQ KISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCYEIYMADTPSVAVQAP PGYGKTELFHLPLIALASKGDVEYVSFLFVPYTVLLANCMIRLGRRGCLNVAPVRNFI EEGYDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFET EVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKR SEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIRKKVESQPEEALKLLLALFESEPES KAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMQVLIGTKL VTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPP IKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATAS MSIVALPSSFQESNSSDRYRKYCSSDEDSNTCIHGSANASTNASTNAITTASTNVRTN ATTNASTNATTNASTNASTNATTNASTNATTNSSTNATTTASTNVRTSATTTASINVR TSATTTESTNSSTNATTTESTNSSTNATTTESTNSNTSATTTASINVRTSATTTESTN SSTSATTTASINVRTSATTTKSINSSTNATTTESTNSNTNATTTESTNSSTNATTTES TNSSTNATTTESTNSNTSAATTESTNSNTSATTTESTNASAKEDANKDGNAEDNRFHP VTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDI YFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRIAWEALAVERMLRNDEEYKEYL EDIEPYHGDPVGYLKYFSVKRREIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQ VFRMSGRQIKELYFKVWSNLRESKTEVLQYFLNWDEKKCQEEWEAKDDTVVVEALEKG GVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQIALGVTPSKVPH WTAFLSMLIGLFYNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADDTRVPLYML MVAVHKELDSDDVPDGRFDILLCRDSSREVGE" rep_origin 7445..7943 /note="ARS1002; Autonomously Replicating Sequence" /db_xref="SGD:S000028439" gene complement(8776..9138) /gene="PAU1" /locus_tag="YJL223C" mRNA complement(8776..9138) /gene="PAU1" /locus_tag="YJL223C" /product="seripauperin PAU1" CDS complement(8776..9138) /gene="PAU1" /locus_tag="YJL223C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; active during alcoholic fermentation; regulated by anaerobiosis, negatively regulated by oxygen; repressed by heme; identical to Pau14p" /codon_start=1 /product="seripauperin PAU1" /protein_id="DAA08590.1" /db_xref="SGD:S000003759" /translation="MVKLTSIAAGVAAIAATASATTTLAQSDERVNLVELGVYVSDIR AHLAQYYMFQAAHPTETYPVEVAEAVFNYGDFTTMLTGISPDQVTRMITGVPWYSSRL KPAISSALSKDGIYTIAN" gene 11475..16124 /gene="VTH2" /locus_tag="YJL222W" mRNA 11475..16124 /gene="VTH2" /locus_tag="YJL222W" /product="signal sequence-binding protein" CDS 11475..16124 /gene="VTH2" /locus_tag="YJL222W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0005048 signal sequence binding [PMID:8636229]" /experiment="EXISTENCE:genetic interaction:GO:0006623 protein targeting to vacuole [PMID:8636229]" /experiment="EXISTENCE:genetic interaction:GO:0006896 Golgi to vacuole transport [PMID:8662642]" /note="Putative membrane glycoprotein; has strong similarity to Vth1p and Pep1p/Vps10p; may be involved in vacuolar protein sorting" /codon_start=1 /product="signal sequence-binding protein" /protein_id="DAA08591.1" /db_xref="SGD:S000003758" /translation="MALFRALYIIWVFLLIPLSNAEEFTPKVTRTLSRYVFDIVNFDD SNTLIRAEEDSVEISFDAGENWKTIDEIEEPIESFVVDPFRGHDRAFAFVKTAPKFYV TDDQGKSWRPLTIPISEKASNYFCDVTTHPIKKKHLIIRCDLLTIKNSGLMYVGREIY TTNDGVSFSQVKPSFGKIDGHISTARCDFIKSSEDSDLGGNDASILCLFRNTEYIEST GSTIDKSELILSADGGETFKELVQFKDKVVSRYEILKHHVIVLTQDDMYNEMSSTNIW ISNDVSTFQVARTPTKIRHVNMGQIHEDSIGRIVLPVSRERDDEDSNQPGAAEVLISD SEGLKFLPINWIPNNQFGYINVAYPGFLKGTFFGSFHPFIEYSDRKRKYSRQKVREET KVSVDNGLTWTNLKVVDRENVDLFGCDVTKPERCSLQTHFYDLRNLNPSAGIMMISGI VGDGSAYNWKEEKTFISRDSGLTWRLVHNSTGLYTTGDLGNIIMYIPYRSNENGDVPS KFYYSLDQGKTWGEYDLIMPIYPYRLVSTISDGSGSKFILTGTSITEDPIFITYSIDF SAVFDYKSCEEGDFEDWNLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLSLDETPCN SCTGSDYECSFEFVRDAKGDCIPDYNLIALSDICDKSKGKSVLVKPLQLIKGDKCKTP MKIESVDIPCDEIPKEGSSDKEIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAY ISHDGGQTIKRFDTDGEKIVEIVFNPYFNSSAYLFGSKGNIFLTHDRGYSFMIAKLPE ARQLGMPLDFSAKAQDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTEMLDNAIHC EFAGTLFKYPSNDDMVMCQVKEKFSQTRSLVSSTDFFQDDRKTVFENIIGYLSTGGYI IVAVPHEDNELRAYVTNDGAEFTEAKFPYDEDIGKQDAFTILGSEEGSIFLHLATNLE SGHDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNSEKVGE NKEDEQLKTKITFNDGSDWNFLKPPKKDSEGKKFPCDSVSLDKCSLHLHGYTERKDIR DTYSSGSALGMMFGVGNVGDRLLPYEECSTFLTTDGGETWTEVKKGPHQWEYGDHGGV LVLVPENAETDSISYSTDFGKTWKDYKFCGDKVLVKDIITVPRDSALRFLLFGEAKNM GSGSFRTYTIDFRNIFERQCEFDITGRKRADFKYSPLGSRTGCLFGHKTEFLRKTDEK CFIGNIPLSEFSRNVKNCPCTRQDFECDYNFYKASDGTCKLVKGLSSANGADICKKEP DLIEYYDSSGYRKIPLSTCKGGLKLDAHLAPHPCPGKEKAFREKYSINTGAYALVFVT ILLVIFFVAWFVYDRGIRRNGGFSRFEEIRLGDDGLIENNRTDRVVNIIVRLGLCISL ITKSAFQRAKAGTAQLSSKFRARFGNKKGATYSSLLHDQLSDEPDGFHEDSNDLSSFR GQGSNSEIEQEDVDTSQQEHTSRTDLLGASNIPDALPARSASHESDLAAARSEDK" rep_origin 16124..16762 /note="ARS1003; Autonomously Replicating Sequence" /db_xref="SGD:S000028440" gene complement(16767..18536) /gene="IMA4" /locus_tag="YJL221C" /gene_synonym="FSP2" mRNA complement(16767..18536) /gene="IMA4" /locus_tag="YJL221C" /gene_synonym="FSP2" /product="oligo-1,6-glucosidase IMA4" CDS complement(16767..18536) /gene="IMA4" /locus_tag="YJL221C" /gene_synonym="FSP2" /EC_number="3.2.1.10" /experiment="EXISTENCE:genetic interaction:GO:0046352 disaccharide catabolic process [PMID:20562106]" /experiment="EXISTENCE:mutant phenotype:GO:0004574 oligo-1,6-glucosidase activity [PMID:20562106]" /note="Alpha-glucosidase; weak, but broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima4p overexpression allows the ima1 null mutant to grow on isomaltose; identical to IMA3" /codon_start=1 /product="oligo-1,6-glucosidase IMA4" /protein_id="DAA08592.1" /db_xref="SGD:S000003757" /translation="MTISSAHPETEPKWWKEATIYQIYPASFKDSNNDGWGDMKGIAS KLEYIKELGTDAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGM KFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWRSYFG GSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGS LYSKVAGLPDAPVIDENSKWQLSDPFTMNGPRIHEFHQEMNKFIRNRVKDGREIMTVG EMRHATDETKRLYTSASRHELSELFNFSHTDVGTSPKFRQNLIPYELKDWKVALAELF RYVNGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLVSLSGTLYVYQGQ ELGEINFKNWPIEKYEDVEVRNNYDAIKEEHGENSKEMKRFLEAIALISRDHARTPMQ WSREEPNAGFSGPNAKPWFYLNESFREGINAEDESKDPNSVLNFWKEALRFRKAHKDI TVYGYDFEFIDLDNKKLFSFTKKYDNKTLFAALNFSSDSIDFTIPNNSSSFKLEFGNY PRSEVDASSRTLKPWEGRIYISE" gene 19497..21200 /gene="HXT9" /locus_tag="YJL219W" mRNA 19497..21200 /gene="HXT9" /locus_tag="YJL219W" /product="hexose transporter HXT9" CDS 19497..21200 /gene="HXT9" /locus_tag="YJL219W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0005354 galactose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0015578 mannose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0055056 D-glucose transmembrane transporter activity [PMID:10618490]" /note="Putative hexose transporter that is nearly identical to Hxt11p; has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p" /codon_start=1 /product="hexose transporter HXT9" /protein_id="DAA08593.1" /db_xref="SGD:S000003755" /translation="MSGVNNTSANDLSTTESNSNSVANAPSVKTEHNDSKNSLNLDAT EPPIDLPQKPLSAYTTVAILCLMIAFGGFIFGWDTGTISGFVNLSDFIRRFGQKNDKG TYYLSKVRMGLIVSIFNIGCAIGGIVLSKVGDIYGRRIGLITVTAIYVVGILIQITSI NKWYQYFIGRIISGLGVGGIAVLSPMLISEVAPKQIRGTLVQLYQLMCTMGIFLGYCT NYGTKNYHNATQWRVGLGLCFAWTTFMVSGMMFVPESPRYLIEVGKDEEAKRSLSKSN KVSVDDPALLAEYDTIKAGIELEKLAGNASWSELLSTKTKVFQRVLMGVMIQSLQQLT GDNYFFYYGTTIFKSVGLKDSFQTSIIIGVVNFFSSFIAVYTIERFGRRTCLLWGAAS MLCCFAVFASVGVTKLWPQGSSHQDITSQGAGNCMIVFTMFFIFSFATTWAGGCYVIV SETFPLRVKSRGMAIATAANWMWGFLISFFTPFITGAINFYYGYVFLGCLVFAYFYVF FFVPETKGLTLEEVNTMWLEGVPAWKSASWVPPERRTADYDADAIDHDDRPIYKRFFS S" gene 21973..22563 /locus_tag="YJL218W" mRNA 21973..22563 /locus_tag="YJL218W" /product="acetyltransferase" CDS 21973..22563 /locus_tag="YJL218W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:31945465]" /note="Mitochondrial protein, putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in OAF1/PIP2-dependent manner; promoter contains oleate response element consensus sequence; mutation decreases salt tolerance; non-essential gene" /codon_start=1 /product="acetyltransferase" /protein_id="DAA08594.1" /db_xref="SGD:S000003754" /translation="MGVLENIVPGELYDANYDPDLLKIRKETKIKLHEYNTLSPADEN KKSQVIRELLGSCTDNFIIEPPFYCDYGSNIYIGDNFYANHNLVILDGAKVVIGDNVF IAPNVGIYTAGHPIDVERRLQGLEYAMPVTIGDNVWIGGGVSIIPGVNIGKNSVIAAG SVVIRDIPENVVAAGNPCKVIRKITEKDSTTTNYRK" gene 23133..23729 /gene="REE1" /locus_tag="YJL217W" mRNA 23133..23729 /gene="REE1" /locus_tag="YJL217W" /product="Ree1p" CDS 23133..23729 /gene="REE1" /locus_tag="YJL217W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle" /codon_start=1 /product="Ree1p" /protein_id="DAA08595.1" /db_xref="SGD:S000003753" /translation="MVESKNTELSQGTWLNKPKSVFQEAGKVTLETDEKTDFWRETFY GFTRDSGHFLGVETGSAFTAQVRVQGSYESLYDQAGIMVRIDDGHWLKAGIEISDGHA MLSSVLTNGKSDWSTAVYGGNARDFWLRVTVEKGVLRIQVSSDKKTWPLVRLAPFPTS DHYLVGPMACTPERGGLKVTFSEWSLTAPLGKALHDLS" rep_origin 23662..24158 /note="ARS1004; Autonomously Replicating Sequence" /db_xref="SGD:S000028441" gene complement(24341..26086) /gene="IMA5" /locus_tag="YJL216C" mRNA complement(24341..26086) /gene="IMA5" /locus_tag="YJL216C" /product="oligo-1,6-glucosidase IMA5" CDS complement(24341..26086) /gene="IMA5" /locus_tag="YJL216C" /EC_number="3.2.1.10" /experiment="EXISTENCE:direct assay:GO:0004574 oligo-1,6-glucosidase activity [PMID:20471265]" /experiment="EXISTENCE:genetic interaction:GO:0046352 disaccharide catabolic process [PMID:20471265|PMID:20562106]" /experiment="EXISTENCE:mutant phenotype:GO:0004574 oligo-1,6-glucosidase activity [PMID:20562106]" /note="Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; most distant member of the IMA isomaltase family, but with similar catalytic properties as Ima1p and Ima2p; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose; can cleave alpha-1,3 linkage of nigerose and turanose and alpha-1,5 linkage of leucrose and is very sensitive to temperature in vitro" /codon_start=1 /product="oligo-1,6-glucosidase IMA5" /protein_id="DAA08596.1" /db_xref="SGD:S000003752" /translation="MTIIHNPKWWKEATVYQIYPASFKDSNNDGWGDLAGITSKLDYV KELGVDAIWVCPFYDSPQEDMGYDIANYEKVWPRYGTNEDCFQMIEEAHKRGIKVIVD LVINHCSEEHEWFKESRSSKANPKRDWFFWRPPKGYDEKGNPIPPNNWRSFFGGSAWR YDEKTGEFFLHVFALGQPDFNWENEECRKAIYDSSVGYWLRHNVDGFRIDVGSMYSKV EGLPDAPITDPTVPYQKGTEFFINGPRIHEYHKEMHNYMLSQVPEGKEIMTVGEVGIG NEDDFRVYTSAKEGELNMMFNFKHTSVGENPKCKYELIPFTLKDFKLALAESFLFIEN TDCWSTIYLENHDQPRSVSRFGSDSPKWREISSKMLATLIISLTGTVFIYQGQELGMP NFKNRKIEQIKCVEGTGTYAAIKRDYGEDSEKMKKFFEALALISRDHGRTPFPWSADE PSAGFSKDAKPWIDMNESFRDGINAEAELKDKNSVFFFWKKALQVRKEHKDILVYGHN FQFIDLDNDKLFMFTKDTDNKKMFAVFNFSSDNTDFSVPDNEASYTMFFGNYANSNGD SRTLQPWEGRLYLLK" gene 26887..28596 /gene="HXT8" /locus_tag="YJL214W" mRNA 26887..28596 /gene="HXT8" /locus_tag="YJL214W" /product="hexose transporter HXT8" CDS 26887..28596 /gene="HXT8" /locus_tag="YJL214W" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0015578 mannose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0055056 D-glucose transmembrane transporter activity [PMID:10618490]" /note="hypothetical protein with similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" /codon_start=1 /product="hexose transporter HXT8" /protein_id="DAA08597.1" /db_xref="SGD:S000003750" /translation="MTDRKTNLPEEPIFEEAEDDGCPSIENSSHLSVPTVEENKDFSE YNGEEAEEVVVPEKPASAYATVSIMCLCMAFGGFMSGWDTGTISGFVNQTDFLRRFGN YSHSKNTYYLSNVRTGLIVSIFNVGSAIGCLFLSKLGDIYGRCMGLIIVIVVYMVGIV IQIASIDKWYQYFIGRIIAGIGAGSISVLAPMLISETAPKHIRGTLLACWQLMVTFAI FLGYCTNYGTKTYSNSVQWRVPLGLCFAWAIIMIGGMTFVPESPRFLVQVGKIEQAKA SFAKSNKLSVDDPAVVAEIDLLVAGVEAEEAMGTASWKELFSRKTKVFQRLTMTVMIN SLQQLTGDNYFFYYGTTIFKSVGMNDSFETSIVLGIVNFASCFFSLYSVDKLGRRRCL LLGAATMTACMVIYASVGVTRLYPNGKSEPSSKGAGNCTIVFTCFYIFCFSCTWGPVC YVIISETFPLRVRSKCMSVATAANLLWGFLIGFFTPFITSAINFYYGYVFMGCLAFSY FYVFFFVPETKGLTLEEVDEMWMDGVLPWKSESWVPASRRDGDYDNEKLQHDEKPFYK RMF" gene 32163..33158 /locus_tag="YJL213W" mRNA 32163..33158 /locus_tag="YJL213W" /product="hypothetical protein" CDS 32163..33158 /locus_tag="YJL213W" /note="hypothetical protein that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08598.1" /db_xref="SGD:S000003749" /translation="MLMPKSVALLRIRYTLEAALARGFTTVRDCGGAEGFLKAEIRQG SLNGPRLITCGHAISQTGGHGDLRSGALPASAFDSCSCHFGQVGVVADGVPECYKAAR EEFRRGADFIKIMGGGGVASPTDKISNKQFCDDEIKALVDVANSYHTYVTAHAYTAEA IQNCIKLGVKGIEHGNLLDERTAELMAELGCYLTPTLVTYKVMGSDQFSAFLGPENSR KNTEVLYKGIDAMKIAQKKKVKICFGSDLLGPLYGYQTQEFRIRGKVQTTQEILLSAT VTPAEMNGLGDKLGQIKPGFIADLLMMKSNPLDDITILDEPESNILFVMKEGRIY" gene complement(33850..36249) /gene="OPT1" /locus_tag="YJL212C" /gene_synonym="DUG4" /gene_synonym="GSH11" /gene_synonym="HGT1" mRNA complement(33850..36249) /gene="OPT1" /locus_tag="YJL212C" /gene_synonym="DUG4" /gene_synonym="GSH11" /gene_synonym="HGT1" /product="oligopeptide transporter OPT1" CDS complement(33850..36249) /gene="OPT1" /locus_tag="YJL212C" /gene_synonym="DUG4" /gene_synonym="GSH11" /gene_synonym="HGT1" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19496824]" /experiment="EXISTENCE:direct assay:GO:0006857 oligopeptide transport [PMID:16149917]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:10788431]" /experiment="EXISTENCE:mutant phenotype:GO:0035673 oligopeptide transmembrane transporter activity [PMID:10652283]" /note="Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family" /codon_start=1 /product="oligopeptide transporter OPT1" /protein_id="DAA08599.1" /db_xref="SGD:S000003748" /translation="MSTIYRESDSLESEPSPTPTTIPIQINMEEEKKDAFVKNIDEDV NNLTATTDEEDRDPESQKFDRHSIQEEGLVWKGDPTYLPNSPYPEVRSAVSIEDDPTI RLNHWRTWFLTTVFVVVFAGVNQFFSLRYPSLEINFLVAQVVCYPIGRILALLPDWKC SKVPFFDLNPGPFTKKEHAVVTIAVALTSSTAYAMYILNAQGSFYNMKLNVGYQFLLV WTSQMIGYGAAGLTRRWVVNPASSIWPQTLISVSLFDSLHSRKVEKTVANGWTMPRYR FFLIVLIGSFIWYWVPGFLFTGLSYFNVILWGSKTRHNFIANTIFGTQSGLGALPITF DYTQVSQAMSGSVFATPFYVSANTYASVLIFFVIVLPCLYFTNTWYAKYMPVISGSTY DNTQNKYNVTKILNEDYSINLEKYKEYSPVFVPFSYLLSYALNFAAVIAVFVHCILYH GKDIVAKFKDRKNGGTDIHMRIYSKNYKDCPDWWYLLLQIVMIGLGFVAVCCFDTKFP AWAFVIAILISLVNFIPQGILEAMTNQHVGLNIITELICGYMLPLRPMANLLFKLYGF IVMRQGLNLSRDLKLAMYMKVSPRLIFAVQIYATIISGMVNVGVQEWMMHNIDGLCTT DQPNGFTCANGRTVFNASIIWSLPKYLFSSGRIYNPLMWFFLIGLLFPLAVYAVQWKF PKFKFAKHIHTPVFFTGPGNIPPSTPYNYSLFFAMSFCLNLIRKRWRAWFNKYNFVMG AGVEAGVAISVVIIFLCVQYPGGKLSWWGNNVWKRTYDNDYKKFYTLKKGETFGYDKW W" gene 36919..37734 /gene="PEX2" /locus_tag="YJL210W" /gene_synonym="CRT1" /gene_synonym="PAS5" mRNA 36919..37734 /gene="PEX2" /locus_tag="YJL210W" /gene_synonym="CRT1" /gene_synonym="PAS5" /product="ubiquitin-protein ligase peroxin 2" CDS 36919..37734 /gene="PEX2" /locus_tag="YJL210W" /gene_synonym="CRT1" /gene_synonym="PAS5" /EC_number="2.3.2.36" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:35768507|PMID:12876220]" /experiment="EXISTENCE:direct assay:GO:0006513 protein monoubiquitination [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0044721 protein import into peroxisome matrix, substrate release [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:35768507|PMID:19687296|PMID:22471590]" /experiment="EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:22375831]" /experiment="EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:15536088]" /note="RING-finger peroxin and E3 ubiquitin ligase; peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import" /codon_start=1 /product="ubiquitin-protein ligase peroxin 2" /protein_id="DAA08600.1" /db_xref="SGD:S000003746" /translation="MSRVAQLDSIALDKELYGQFWSEFNAAFNTSEHKEEWELALNTV VFMCATRFLPHYGSSCTYGSALSGVVFQCRKRTLYVVTVLAGYVWKKITHIIFNGPHC GNQMMWLKLYKWVNLLYHGCDVTNFLRFLAAEGPNARAFLSPLYRAFNVHSTRLIRDG SAIASEFYSNSVFAGLEYQNRQLLWNALLELFSNTLLTKRGLLTFVKKPPRSRSTTTY KTVCPRCGGFPTNPYQIACCRANYCYVCVVKALEWSMCDACGSSGRLTASPVY" gene 38005..39969 /gene="CBP1" /locus_tag="YJL209W" mRNA 38005..39969 /gene="CBP1" /locus_tag="YJL209W" /product="Cbp1p" CDS 38005..39969 /gene="CBP1" /locus_tag="YJL209W" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:9343381]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:2104848|PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0000958 mitochondrial mRNA catabolic process [PMID:9343381]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:9343381]" /note="Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress" /codon_start=1 /product="Cbp1p" /protein_id="DAA08601.1" /db_xref="SGD:S000003745" /translation="MFLPRLVRYRTERFIKMVPTRTLRRINHSSRDPIQKQVLALIKA NANLNDNDKLKIRKYWSDMADYKSLRKQENSLLESSILHEVKIEDFISFINRTKTSSM TTRGIYRRECLYQCKKNLDLVNQVVSQVSSVRHQKPLTTQLDTMRWCVDDAIGTGDIV MAADLFLLYYRLFTDDKKLDEQYAKKIISVLAYPNPLHDHVHLVKYLQLNSLFESITG GGIKLTRFQLETLSNKALGLSNEAPQLCKAILNKLMNINYSLTNDLKLRDDQVLLAYK SIDENYRRGNVASVYSIWNKIKEHYVSISAHDSRIIYKVFKICTHNRAYRSICSEMFW QLTPEYYCNNPLILPAIIDFITKQDSLTMAKELMQNINRYTLPENHHIVWLNKRCLSS LLRMHLKFNDSNGVDRVLKQITTNFRALSQENYQAIIIHLFKTQNLDHIAKAVKLLDT IPPGQAMLAYGSIINEVVDWKLASKVKFTDNLMALVNDLLTKAHDFDPDHRNSLWNVV SALYIKKLCHYKKRDGKFVANAKKDIDLAKLLYINAAKRSKTYWTKSNCNPFIASSPC DVKLKVNNQNRFTILRNIALSALQIGRTDIFLWACAELYQNGMTIEELKLDWNFILKH QIRNSEFKTNKEIIQDIKKHGVSAVKRYLR" gene complement(40194..41183) /gene="NUC1" /locus_tag="YJL208C" mRNA complement(40194..41183) /gene="NUC1" /locus_tag="YJL208C" /product="ribonuclease" CDS complement(40194..41183) /gene="NUC1" /locus_tag="YJL208C" /experiment="EXISTENCE:direct assay:GO:0004520 DNA endonuclease activity [PMID:3286639]" /experiment="EXISTENCE:direct assay:GO:0004529 DNA exonuclease activity [PMID:3286639]" /experiment="EXISTENCE:direct assay:GO:0004540 RNA nuclease activity [PMID:3286639]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17244531]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:3286639|PMID:17244531]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:31266891]" /experiment="EXISTENCE:direct assay:GO:0006308 DNA catabolic process [PMID:3286639]" /experiment="EXISTENCE:direct assay:GO:0006401 RNA catabolic process [PMID:3286639]" /experiment="EXISTENCE:direct assay:GO:0051607 defense response to virus [PMID:31266891]" /experiment="EXISTENCE:mutant phenotype:GO:0006309 apoptotic DNA fragmentation [PMID:22727375]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:8087883]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:17244531]" /note="Major mitochondrial nuclease; has RNAse and DNA endo- and exonucleolytic activities; prevents genome instability by degrading extranuclear DNA sequences; roles in mitochondrial recombination, apoptosis and maintenance of polyploidy; involved in fragmentation of genomic DNA during PND (programmed nuclear destruction); role in preventing L-A mycovirus pathogenesis; encodes ortholog of mammalian endoG" /codon_start=1 /product="ribonuclease" /protein_id="DAA08602.1" /db_xref="SGD:S000003744" /translation="MCSRILLSGLVGLGAGTGLTYLLLNKHSPTQIIETPYPPTQKPN SNIQSHSFNVDPSGFFKYGFPGPIHDLQNREEFISCYNRQTQNPYWVLEHITPESLAA RNADRKNSFFKEDEVIPEKFRGKLRDYFRSGYDRGHQAPAADAKFSQQAMDDTFYLSN MCPQVGEGFNRDYWAHLEYFCRGLTKKYKSVRIVTGPLYLPKKDPIDNKFRVNYEVIG NPPSIAVPTHFFKLIVAEAPTANPAREDIAVAAFVLPNEPISNETKLTDFEVPIDALE RSTGLELLQKVPPSKKKALCKEVNCQIVVRDFSNAAIKQSKDVKLLPPPKKRN" gene complement(41389..47433) /gene="LAA1" /locus_tag="YJL207C" mRNA complement(41389..47433) /gene="LAA1" /locus_tag="YJL207C" /product="Laa1p" CDS complement(41389..47433) /gene="LAA1" /locus_tag="YJL207C" /experiment="EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:16687571]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 protein localization [PMID:16687571]" /experiment="EXISTENCE:mutant phenotype:GO:0035653 clathrin-coated vesicle cargo loading, AP-1-mediated [PMID:30523155]" /experiment="EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:16687571]" /note="AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene" /codon_start=1 /product="AP-1 complex accessory protein LAA1" /protein_id="DAA08603.1" /db_xref="SGD:S000003743" /translation="MANRSLKKVIETSSNNGHDLLTWITTNLEKLICLKEVNDNEIQE VKEIHTQLDEFVRYISVLENTDDLELHSVFISLSQLYTISIWRLKDEYPGVVFDSAAF LTNVLCEEDVSIDDGDTDPNQKKKKKKSSTKKKKYIYSPAKDIACTILVQLFENFGSS ISSLIPLLFNAIFKNLKKIMEKSKYYHATFMTTLLQLFNAILRNSNNDDKILDPATYA KFSKLSKTVFDSISTDEKDFSVTFVSVLIECWTAHFKQTNFIREHSHDIIETIYSRFT EGEIGVYGFANDETRIFTAKSLAEILFDYYFSKNILTLQEVWSIYVKIFLNCDTRDVE SGCFESIIHLINLNLLADNTFLSNSKYLDIVLSLSGVFSSYEVNNRSMNTLSRYLRYF QHMHEVILPHLNDSAKTQMLYYILGCSDTYQSSSKSDSASNFKYSIDAKPETQWLTLL QLDFTYVLISDLGSTFTTEENTVKEIRDKLVDLATCEIFTIRVHTVEILKVFLNNCPE YLSETIENSLRALSTDFKSTGKFIFHKNHGHAFIIANLIKGAESDYISYELIMRITVF STSFIKNNTTSTSSNLYFKGLLCWILLIGLMNYKDEQYLKLQIPQLFLFWKVLLTHTY TYHDEDELYKNLEIRNHALTCLLTYLSNTTIDKEMAKQVSYLLTKCSNFNHSIDLKSK NIDNALLHNENRILQVYLKLEKYINSDFNSSLLILIVKNFSDPNLYTESSSSVLGSLK DIGNRKVSNKDDMESNIVLESSINTLLRQNNGFAFGLSSKITGDRIVNLSMSSAYKYD ESISGSWPSKDYNWYNIFEVEVSKPISPILSLDSLILLYGSGSYSQIDRYAPQVTTSL IDSSMELFSSVFPFLNSKIQYSIMETLNLSMFSKMTTPLRSVAVAANVCSALHNALRI MQENNLELDYSVGQLIIESIKKIQFFNDIFLTKIKADCVGLLTAAIARTLGDEERQKF LTEQSRIFIKNVADMDEPYLRMFHVLSLATIFKYNSQYANFEEYFDVIFALMRDPHPV VHSWSLKAMHILLEKHLVIDLKTAALLLSSMEELLVQDKYGIYGRSTLRCNYNRDFNS HVAIGEISRTLTETVGPNFLELNTKVLDSFRNITLSMLISNNILNSITSIKMFENIAT FKMKNILNYEIFILASKSIIKSSIVTGIGSSYFDTTFTGSNELISRTSSLKGAFENFD LLTLLYKLQMEEFFMKEMENLSWRYLALFPNSGSVKNYFTEWILHTFKRDNHWFDKLY SIFNMSLGRLFQSYNRDVSALLEVNGLKKSSEKEIKGEEEESIANVNQLTDTDAGGLD SENLQWKSRQIILNLILMLCLESEKYENLLLALSNKIADLIKISFRGSTVRNEGMKLT GLHILNFVLKNYSTMRDPQVPGSSILEQQEAQITSALMPAFSKGSSPTVMSFAITVAA EVLASNIMPPDKLGRISQLLIDLLGNFKDPNSGIRIGEAIIVTPKAKRKIELAVLDAW AEVVQRSITSSNDALFSFTRKYWSILVPLWIISLREYMMIKYNDNDSTVQVKNDSKEN SLIEPRSTKIELYEPVWLNFVEALGCTLDSDVQVILASLNDEELEYFLFILFSQCLEA IVKNIDDHSVKMQVLPALHNVLKSNLCIKSIFEDDIITEVVEIMDRLISTGDSKEEFL LVDIISDLIIGYSKCNATPETFLQDIDKLYELLRLLMTIISERLPFIKYNVLTSEEDD NEIKISPTDISLLKKTFIAFESNISNFDNMFKVDLYSCLLFIIGKIYECSHREVIIPI ILPLFKALVKALTESEDEKNIVLLEIFYGSIKDVIYHKLDSKNKVATILILLSNGYSK LSFQELNQCANILSEALNNPATQPIALQGFKRIISNIFKYPLLQYFMKLVIKRFFQDI QTNDSLSQASIKTKLIIQFSEEVIKQDHQKASLSIALCLSFFAAYHSAYTEKIDNEVA SGIVALAKLDKNSFKEAISSTISPQQKAIIGSVMEAYVKSQSLGSVEEAFQLKSFD" gene complement(47659..49935) /locus_tag="YJL206C" mRNA complement(47659..49935) /locus_tag="YJL206C" /product="hypothetical protein" CDS complement(47659..49935) /locus_tag="YJL206C" /note="hypothetical protein; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08604.1" /db_xref="SGD:S000003741" /translation="MTPKESGKPISCAMKKLKGKRSKILVLSRDAGTNELKPTKGRAH RACIACRKRKVRCSGNIPCRLCQTNSYECKYDRPPRNSSVFDREVSDDSSLYAQRASH EREDSKGPISSIDYKKVVETIFPPETLRQILASSSFNSQNFLDTIKTCLLQGQLNVNQ VIRQSLPKDTPWHMQTSVPLPPREIALKFIQKTWDCACVLFRFYHRPTIISILDSIYE AEKHGKQYTPEQVKTQPLIYSVLAVGALFSKEDLSKDSKATREFYTDEGYRYFLEAKN SLDFSNITDIYSIQAIFMMTIFLQCSANLKACYSFIGIALRAALKEGLHRRSSIVGPT PIQDETKKRLFWSVYKLDLYMNCILGFPSGIDESDIDQEFPLDVDDENISTIGIKFQD WRTISSCGMNNKHTKLILIMSRIYKLMYSLRRKPLEEDSRTQIVSLNDQLDNWYAQLP DILKVDTIRYRQTQPPLTVSANDTSSPYTKPKKLLYLDFLLSKIVLYKPFYHYISIDP LDIPEFQFQIHMAENCIEVAKKVIQLSYEMITQNLLSGSYWFSIHTIFFSVACLKFYV YQTEKGLIRNGKVDSDIHNATQLGSEILSLLKGASNASKRTFEVLNQLFKEFNEKTSV LSEQLLNIVKLQRQESSGALVPQLQTNNNFTKCQGELHHGQQHHQTPATSLRSILNLP QGEADLKFQNTNNESHTTTAAQEEYLDKLLAEFEEFDYSINRVLPDVIDFSALIGQDS SANNQIFSSEFSSDPTVN" gene complement(50139..50443) /gene="NCE101" /locus_tag="YJL205C" /gene_synonym="NCE1" /gene_synonym="YJL205C-A" /gene_synonym="YJL206C-A" mRNA complement(join(50139..50268,50412..50443)) /gene="NCE101" /locus_tag="YJL205C" /gene_synonym="NCE1" /gene_synonym="YJL205C-A" /gene_synonym="YJL206C-A" /product="Nce101p" CDS complement(join(50139..50268,50412..50443)) /gene="NCE101" /locus_tag="YJL205C" /gene_synonym="NCE1" /gene_synonym="YJL205C-A" /gene_synonym="YJL206C-A" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0009306 protein secretion [PMID:8655575]" /note="hypothetical protein; involved in secretion of proteins that lack classical secretory signal sequences; SWAT-GFP and mCherry fusion proteins localize to the cytosol" /codon_start=1 /product="Nce101p" /protein_id="DAA08605.1" /db_xref="SGD:S000003742" /translation="MVQYAPFLLGKFSDPLLAIMVGCLSYYVYERKMGRPQGHHLHEL IKKRWDDRK" gene complement(50629..53151) /gene="RCY1" /locus_tag="YJL204C" mRNA complement(50629..53151) /gene="RCY1" /locus_tag="YJL204C" /product="Rcy1p" CDS complement(50629..53151) /gene="RCY1" /locus_tag="YJL204C" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:15537705]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:15537705]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:11287615]" /experiment="EXISTENCE:mutant phenotype:GO:0000149 SNARE binding [PMID:11287615]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:11378903|PMID:10769031]" /experiment="EXISTENCE:mutant phenotype:GO:0032456 endocytic recycling [PMID:24272750]" /experiment="EXISTENCE:mutant phenotype:GO:0034498 early endosome to Golgi transport [PMID:15537705]" /note="F-box protein involved in recycling endocytosed proteins; involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth; direct interaction with C-terminal cytoplasmic region of Drs2p plays an important role for Drs2p function in endocytic recycling pathway; required for turnover of histone H3 variant Cse4p" /codon_start=1 /product="Rcy1p" /protein_id="DAA08606.1" /db_xref="SGD:S000003740" /translation="MDDLLKVPEIVTNIASYLSTVDYLSFQQVNKRVYAIINGKNDSK YWSLKLTRMGLQQVHSNEEEEITLLDENDNQNSLRIFEIYKSFTAQNSKKIFVKFYRC YNSYARKLYNNNLANFFPTSYSNDPLKQTRILNFIKKYNFSNKNDIETFTRIETNFNI LREIFINSVLKESELNYQSNNLAAVARFMKILLISNEESNAIEFFKSKADLPPSLTVL PSNDELFWAEQPREEDSGGSTVIFNSKNLDTFLNQLRDFLNEKIKLADILFKDEFPVI LQFIESFIQDILLDILNNILLSYSEFLKENGKDSKANYECVPELYFTFIKKFDTELND SVNAGANFRKVVRDLLNLYLEPFVVNYMNQTTRVFESLINSQLANYDTQVQDKQREQN AKIYNTLKDQTDASSASNNELPNDLSIITETSKTVPEADSKPSTIHQSVHSTDISNDK LDFLSSFTKIFKFSNNENQRLKQQLQLAYNLNLISNNLQNIKSLISLDLCYKILQETS EKTDQIYKFHTIESLLPLIKLRCQEIFKILITQLNKNHVKPAFEKAILLLQKYNPNEI EQIEIKFNSLSPANTQVEPLVQFTELINIGDIILQMISIFYKNELIPKKIIDKNKDFL NDVIQLKKNFETSIDDFVAEGLNIGINKLMDEISFVFKTLQLPDDYNPPPPSRNSPIR DIKPTKCAIRVVELLSNHCFLLTGATDKGTIDVYQQEIGERFFNEIVKHLKKCFISTE GAIWLICDLNYFYDFIANKLKQKNVVPYFVGLKSIGQLYIISGKDSKELGKLISDLGK FNGIFTQEEIYEFVQRRSDWVRVRKDVEKVMYGLGIRDCCIM" gene 53341..54183 /gene="PRP21" /locus_tag="YJL203W" /gene_synonym="SPP91" mRNA 53341..54183 /gene="PRP21" /locus_tag="YJL203W" /gene_synonym="SPP91" /product="Prp21p" CDS 53341..54183 /gene="PRP21" /locus_tag="YJL203W" /gene_synonym="SPP91" /experiment="EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:8969185]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:8065365]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /note="Subunit of the SF3a splicing factor complex; required for spliceosome assembly" /codon_start=1 /product="Prp21p" /protein_id="DAA08607.1" /db_xref="SGD:S000003739" /translation="MEPEDTQLKEDIKTTVNYIKQHGVEFENKLLEDERFSFIKKDDP LHEYYTKLMNEPTDTVSGEDNDRKSEREIARPPDFLFSQYDTGISRRDMEVIKLTARY YAKDKSIVEQMISKDGEARLNFMNSSHPLHKTFTDFVAQYKRVYSFTGQEIKKSKRTI LDNCFERTQYWEFEKDKDREHDKLVELCKIQFAAIPWDKFTQVAKFSIPEDTEIFEGS LDLEQMRLRRVQTGIKLFDSIKPTNEEEKIVSDQGKQKGGDSKGKKRKIRAVGETRLK KSKK" gene 54379..56178 /gene="ECM25" /locus_tag="YJL201W" mRNA 54379..56178 /gene="ECM25" /locus_tag="YJL201W" /product="Ecm25p" CDS 54379..56178 /gene="ECM25" /locus_tag="YJL201W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0042805 actinin binding [PMID:34010635]" /experiment="EXISTENCE:mutant phenotype:GO:0051510 regulation of unidimensional cell growth [PMID:34010635]" /experiment="EXISTENCE:mutant phenotype:GO:0080135 regulation of cellular response to stress [PMID:34010635]" /note="Endocytic site protein required for stress-induced cell elongation; may link the polarization signal with the endocytic machinery to facilitate adaptive morphogenesis under conditions of stress; interacts with the polarity regulator Cdc42p, the SH3 domains of actin patch components and actin filaments; contains a Rho-GAP domain lacking the catalytic arginine finger, PXXP motifs and an xACT (F-actin binding) motif; promoter contains a consensus binding sequence for transcription factor Abf1p" /codon_start=1 /product="Ecm25p" /protein_id="DAA08608.1" /db_xref="SGD:S000003737" /translation="MIDINVNNIFFRSYSVDPNSGHAIYVFDSTYLPASDEIGDKQVY DLLINALMDRLVMKLPQAPYSLVIFSSGFSQRKISWVYGIKMFAKLPKETKFYLQKIF IVHESFFVRSVYQVISNAMNFNFLDSKDSQHDFPSLVHVLDLTSLSELIDITRLRISL NVYLYDYQIREHINVPEEYYNRLTPLAIRQYRQLVFDKIFKKLQNDALLCELIFQKPG NYKKVNIFLDIIKRNNYIDLSQWDIYSLASVWLNYFIKNKAKPLIPIELIPLPIVDDL KFTSETFRKIIKFNQYQDLFMVIIPFFNRIIAHGESTKHDSRTLSKALTPALCKEKLS MMTNDRLAIGSRYIKNLLDFFPEIAKEISSPPSSVSSSSTIPVLPKPRKSSPTRYSEL GCLTLPRSRSPSPQRSVTSPTYTPVALQNTPVLKPKSSSRNVSSPSFNAKPPLPIKAV TRPQLSLTSNSNTDLALASSSTDTLSSPTKTPSADSLPLSNSSTDLTISDNIKEMVKD EPAKDKNSVETDIFVQQFESLTLVQNAKIKKFDKELQEKKKKNETTSKTADKFSQKGY SDIKASNKVSRLAALYEERLQGLQVMNEMKQRW" gene complement(56444..58813) /gene="ACO2" /locus_tag="YJL200C" mRNA complement(56444..58813) /gene="ACO2" /locus_tag="YJL200C" /product="aconitate hydratase ACO2" CDS complement(56444..58813) /gene="ACO2" /locus_tag="YJL200C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:14562095|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:mutant phenotype:GO:0006099 tricarboxylic acid cycle [PMID:30834327]" /note="Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol" /codon_start=1 /product="aconitate hydratase ACO2" /protein_id="DAA08609.1" /db_xref="SGD:S000003736" /translation="MLSSANRFYIKRHLATHANMFPSVSKNFQTKVPPYAKLLTNLDK IKQITNNAPLTLAEKILYSHLCDPEESITSSDLSTIRGNKYLKLNPDRVAMQDASAQM ALLQFMTTGLNQTSVPASIHCDHLIVGKDGETKDLPSSIATNQEVFDFLESCAKRYGI QFWGPGSGIIHQIVLENFSAPGLMMLGTDSHTPNAGGLGAIAIGVGGADAVDALTGTP WELKAPKILGVKLTGKLNGWSTPKDVITKLAGLLTVRGGTGYIVEYFGEGVSTLSCTG MATICNMGAEIGATTSTFPYQEAHKRYLQATNRAEVAEAADVALNKFNFLRADKDAQY DKVIEIDLSAIEPHVNGPFTPDLSTPISQYAEKSLKENWPQKVSAGLIGSCTNSSYQD MSRVVDLVKQASKAGLKPRIPFFVTPGSEQIRATLERDGIIDIFQENGAKVLANACGP CIGQWNREDVSKTSKETNTIFTSFNRNFRARNDGNRNTMNFLTSPEIVTAMSYSGDAQ FNPLTDSIKLPNGKDFKFQPPKGDELPKRGFEHGRDKFYPEMDPKPDSNVEIKVDPNS DRLQLLEPFKPWNGKELKTNVLLKVEGKCTTDHISAAGVWLKYKGHLENISYNTLIGA QNKETGEVNKAYDLDGTEYDIPGLMMKWKSDGRPWTVIAEHNYGEGSAREHAALSPRF LGGEILLVKSFARIHETNLKKQGVLPLTFANESDYDKISSGDVLETLNLVDMIAKDGN NGGEIDVKITKPNGESFTIKAKHTMSKDQIDFFKAGSAINYIGNIRRNE" gene complement(59100..59172) /locus_tag="YNCJ0001C" tRNA complement(59100..59172) /locus_tag="YNCJ0001C" /product="tRNA-Thr" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Threonine tRNA (tRNA-Thr), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006743" repeat_region 59505..59784 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007027" gene complement(59856..60182) /gene="MBB1" /locus_tag="YJL199C" mRNA complement(59856..60182) /gene="MBB1" /locus_tag="YJL199C" /product="Mbb1p" CDS complement(59856..60182) /gene="MBB1" /locus_tag="YJL199C" /note="hypothetical protein; conserved among S. cerevisiae strains, not conserved in closely related Saccharomyces species; protein detected via large-scale protein-protein interaction studies and enrichment-based proteogenomics; YJL199C is not an essential gene" /codon_start=1 /product="Mbb1p" /protein_id="DAA80306.1" /db_xref="SGD:S000003735" /translation="MYKVSACGVRIMSGISEIWIGELRDYKYALRLDREEYPAVLVYE YDSSSTRNYLFTIKYSDQRPNWQLITRDAALTAYDLLNRGGEFTTLSFPGATIHRSVS ELSRLH" gene 60844..63489 /gene="PHO90" /locus_tag="YJL198W" mRNA 60844..63489 /gene="PHO90" /locus_tag="YJL198W" /product="SPX domain-containing inorganic phosphate transporter" CDS 60844..63489 /gene="PHO90" /locus_tag="YJL198W" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:21143198]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0005315 phosphate transmembrane transporter activity [PMID:11779791]" /experiment="EXISTENCE:genetic interaction:GO:0006817 phosphate ion transport [PMID:11779791]" /experiment="EXISTENCE:genetic interaction:GO:2000185 regulation of phosphate transmembrane transport [PMID:12821119]" /experiment="EXISTENCE:mutant phenotype:GO:0005315 phosphate transmembrane transporter activity [PMID:12581367]" /experiment="EXISTENCE:mutant phenotype:GO:0006797 polyphosphate metabolic process [PMID:17804816]" /note="Low-affinity phosphate transporter; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication" /codon_start=1 /product="SPX domain-containing inorganic phosphate transporter" /protein_id="DAA08610.1" /db_xref="SGD:S000003734" /translation="MRFSHFLKYNAVPEWQNHYMDYSELKNLIYTLQTDELQVGDNEE GFGAGKSSNITDRFKNKFSFKNAKEDTSSGMNKDAGIVEETIELRELPTAQTVAAKPS PFRRMKEKIFYKRRSSSASSVSSTANENLQLDTYDTFVGDLTAEKQKVDDFYKRTEAK FYDKFDALVKDLKKIGVIEYDIDDDTLFNEPIASTNDEVPPLDLDDDEDDDEFYDDQS NIEDNTALLHHSQYNIKSQKKSLLKKSIVNLYIDLCQLKSFIELNRIGFAKITKKSDK VLHLNTRTELIESEQFFKDTYAFQAETIELLNSKISQLVTFYARITDRPHNISHSKQE LKSYLHDHIVWERSNTWKDMLGLLSQADELTPKETEYNANKLVGKLDLEYYRWPLPRP INLKFTSINNVALPKLFFTKKAYKIYFIILVTGLLLGIKTFNDAAQHRCMALVECVAF LWASEAIPLHITAFLVPLLVVLFKVLKTSDGAIMSAASASSEILAAMWSSTIMILLAG FTLGEVLAQYNIAKVLASWLLAFAGCKPRNVLLMAMCVVFFLSMWISNVAAPVLTYSL LSPLLDAMDADSPFAQALVLGVALAANIGGMSSPISSPQNIISMSYLKPYGIGWGQFF AVALPSGILAMLLVWILLFTTFKMNKTKLEKFKPIKTKFTVKQYYIITVTVATILLWC VESQIEGAFGSSGQIAIIPIVLFFGTGLLSTQDLNAFPWSIVILAMGGIALGKAVSSS GLLSTIAKALQKKIENDGVFAILCIFGILMLVVGTFVSHTVSAIIIIPLVQEVGDKLG NPKAAPILVFGCALLSSCGMGLASSGFPNVTAISKVDRKGDRYLSVMTFLTRGVPASI LAFLCVITLGYGIMASVVKGNATSA" gene 63805..67569 /gene="UBP12" /locus_tag="YJL197W" mRNA 63805..67569 /gene="UBP12" /locus_tag="YJL197W" /product="putative ubiquitin-specific protease UBP12" CDS 63805..67569 /gene="UBP12" /locus_tag="YJL197W" /EC_number="3.4.19.12" /experiment="EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:29309037]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:31665643]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:31665643]" /experiment="EXISTENCE:genetic interaction:GO:0016579 protein deubiquitination [PMID:31665643]" /experiment="EXISTENCE:mutant phenotype:GO:0010637 negative regulation of mitochondrial fusion [PMID:23317502]" /experiment="EXISTENCE:mutant phenotype:GO:0016579 protein deubiquitination [PMID:29309037|PMID:23317502]" /note="Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm" /codon_start=1 /product="putative ubiquitin-specific protease UBP12" /protein_id="DAA08611.1" /db_xref="SGD:S000003733" /translation="MGSSDVSSRECSLVYNEDPDFTDGTTPCDRLGVDLMNVLDDKDE IKQESVPVSDREIEDTESDASAVSSFASANELIAEPHAASETNLGTNGQDGRNVLEQQ RDVVARLIEENKETQKEGDKVCIVPKVWYDKFFDPDVTDPEDIGPINTRMICRDFENF VLEDYNRCPYLSIAEPVFNFLSEIYGMTSGSYPVVTNLVINQTTGELETEYNKWFFRL HYLTEKQDGRKRRHGQDDSIMYLSMSALNLVRDLVEKSMNLFFEKADHLDVNAVDFKI WFVSEGSDIATDSNVSTFLNSSYEITPLQFLELPIKKLLIPDMFENRLDKITSNPSDL VIEIKPIEGNHHWPSNYFAYNKLEPASGTTGLVNLGNTCYMNSALQCLVHIPQLRDYF LYDGYEDEINEENPLGYHGYVARAFSDLVQKLFQNRMSIMQRNAAFPPSMFKSTIGHF NSMFSGYMQQDSQEFLAFLLDSLHEDLNRIIKKEYTEKPSLSPGDDVNDWNVVKKLAD DTWEMHLKRNCSVITDLFVGMYKSTLYCPECQNVSITFDPYNDVTLPLPVDTVWDKTI KIFPMNSPPLLLEVELSKSSTYMDLKNYVGKMSGLDPNTLFGCEIFSNQIYVNYESTE SNAQFLTLQELIKPADDVIFYELPVTNDNEVIVPVLNTRIEKGYKNAMLFGVPFFITL KEDELNNPGAIRMKLQNRFVHLSGGYIPFPEPVGNRTDFADAFPLLVEKYPDVEFEQY KDILQYTSIKVTDKDKSFFSIKILSVEKEQQFASNNRTGPNFWTPISQLNLDKATDID DKLEDVVKDIYNYSSLVDCAEGVLMQVDDEGDTEGSEAKNFSKPFQSGDDEENKETVT NNENVNNTNDRDEDMELTDDVEEDASTEPELTDKPEALDKIKDSLTSTPFAILSMNDI IVCEWSELGSNEAFSDDKIYNWENPATLPNKELENAKLERSNAKERTITLDDCLQLFS KPEILGLTDSWYCPTCKEHRQATKQIQLWNTPDILLIHLKRFESQRSFSDKIDATVNF PITDLDLSRYVVYKDDPRGLIYDLYAVDNHYGGLGGGHYTAYVKNFADNKWYYFDDSR VTETAPENSIAGSAYLLFYIRRHKDGNGLGSSKLQEIIQKSRHGYDERIKKIYDEQMK LYEFNKTDEEEDVSDDMIECNEDVQAPEYSNRSLEVGHIETQDCNDEDDNDDGERTNS GRRKLRLLKKVYKNNSGLGSSSTSEISEGCPENEVADLNLKNGVTLESPE" rep_origin 67663..67736 /note="ARS1005; Autonomously Replicating Sequence" /db_xref="SGD:S000028442" gene complement(67850..68782) /gene="ELO1" /locus_tag="YJL196C" mRNA complement(67850..68782) /gene="ELO1" /locus_tag="YJL196C" /product="fatty acid elongase ELO1" CDS complement(67850..68782) /gene="ELO1" /locus_tag="YJL196C" /EC_number="2.3.1.199" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0009922 fatty acid elongase activity [PMID:12684876]" /experiment="EXISTENCE:mutant phenotype:GO:0019368 fatty acid elongation, unsaturated fatty acid [PMID:10850979]" /note="Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, ELO2, that arose from the whole genome duplication" /codon_start=1 /product="fatty acid elongase ELO1" /protein_id="DAA08612.1" /db_xref="SGD:S000003732" /translation="MVSDWKNFCLEKASRFRPTIDRPFFNIYLWDYFNRAVGWATAGR FQPKDFEFTVGKQPLSEPRPVLLFIAMYYVVIFGGRSLVKSCKPLKLRFISQVHNLML TSVSFLWLILMVEQMLPIVYRHGLYFAVCNVESWTQPMETLYYLNYMTKFVEFADTVL MVLKHRKLTFLHTYHHGATALLCYNQLVGYTAVTWVPVTLNLAVHVLMYWYYFLSASG IRVWWKAWVTRLQIVQFMLDLIVVYYVLYQKIVAAYFKNACTPQCEDCLGSMTAIAAG AAILTSYLFLFISFYIEVYKRGSASGKKKINKNN" gene 69338..70879 /gene="CDC6" /locus_tag="YJL194W" mRNA 69338..70879 /gene="CDC6" /locus_tag="YJL194W" /product="AAA family ATPase CDC6" CDS 69338..70879 /gene="CDC6" /locus_tag="YJL194W" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:9288745|PMID:9159120]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:9288745|PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:8083240]" /experiment="EXISTENCE:direct assay:GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity [PMID:8930895]" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:8083240]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:8083240]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:8083240]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]" /experiment="EXISTENCE:direct assay:GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity [PMID:8930895]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:10075735]" /experiment="EXISTENCE:mutant phenotype:GO:0003682 chromatin binding [PMID:10075735]" /experiment="EXISTENCE:mutant phenotype:GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity [PMID:11460169]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:10075735]" /experiment="EXISTENCE:mutant phenotype:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:8538771|PMID:23376927|PMID:9335335|PMID:10075735]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:9990508]" /experiment="EXISTENCE:mutant phenotype:GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity [PMID:11460169]" /experiment="EXISTENCE:mutant phenotype:GO:0140530 MCM complex loading [PMID:29795547]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:10075735|PMID:9312054]" /note="Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; dual role as a mitotic cyclin-dependent kinase inhibitor, that binds to and inhibits Cdc28p/Clb2p along with Sic1p, contributing to mitotic exit; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress; degraded in response to plasma membrane stress" /codon_start=1 /product="AAA family ATPase CDC6" /protein_id="DAA08613.1" /db_xref="SGD:S000003730" /translation="MSAIPITPTKRIRRNLFDDAPATPPRPLKRKKLQFTDVTPESSP EKLQFGSQSIFLRTKALLQKSSELVNLNSSDGALPARTAEYEQVMNFLAKAISEHRSD SLYITGPPGTGKTAQLDMIIRQKFQSLPLSLSTPRSKDVLRHTNPNLQNLSWFELPDG RLESVAVTSINCISLGEPSSIFQKIFDSFQDLNGPTLQIKNMQHLQKFLEPYHKKTTF VVVLDEMDRLLHANTSETQSVRTILELFLLAKLPTVSFVLIGMANSLDMKDRFLSRLN LDRGLLPQTIVFQPYTAEQMYEIVIQKMSSLPTIIFQPMAIKFAAKKCAGNTGDLRKL FDVLRGSIEIYELEKRFLLSPTRGSLNSAQVPLTPTTSPVKKSYPEPQGKIGLNYIAK VFSKFVNNNSTRTRIAKLNIQQKLILCTIIQSLKLNSDATIDESFDHYIKAITKTDTL APLQRNEFLEICTILETCGLVSIKKTKCKGKTKRFVDKIDVDLDMREFYDEMTKISIL KPFLH" gene 71366..72574 /locus_tag="YJL193W" mRNA 71366..72574 /locus_tag="YJL193W" /product="hypothetical protein" CDS 71366..72574 /locus_tag="YJL193W" /note="hypothetical protein; predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08614.1" /db_xref="SGD:S000003729" /translation="MFQQLSASIRHNAHIIFLCISWYFISSLASQVTKQVLTVCPLPL FLGEFQFIYTAVLAWFTCYIAYSFPGFYRIFPNGTFPEYYIDDRETSRAARKESKLSS LIIPPSKPILQTVLPLGLFQFVGKYFGHTATSLVPVSTVASIKTLSPMFILLLQKILK ISTLKITLTLIFSLCTLVLGVWIIVQEDNRSPASSNELREFSKYGVICAMISMFIFVL QNIYGKTVFTYRSQTDESQSNSGFSRQESPLPLYEKLDEKLVAKKKPKSYDKLTLMIY ISLVGFCLSFGWFITLEFPVLFRYFFQINSSSTVIKAFPVSLFLLNGTFHFIQAMITF HLLGEVSTLTYSIANLMKRFAIIAVSWVFIGRRITWLQVFGLVLNTLGLFLYERCTSQ SKIKAKIRPE" gene complement(72710..73414) /gene="SOP4" /locus_tag="YJL192C" /gene_synonym="EMC7" mRNA complement(72710..73414) /gene="SOP4" /locus_tag="YJL192C" /gene_synonym="EMC7" /product="Sop4p" CDS complement(72710..73414) /gene="SOP4" /locus_tag="YJL192C" /gene_synonym="EMC7" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:12230471]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:12230471]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:12230471]" /note="ER-membrane protein; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5 of TOM (Translocase of the Mitochondrial Outer Membrane) complex; suppressor of pma1-7, deletion of SOP4 slows down export of wild-type Pma1p and Pma1-7 from the ER" /codon_start=1 /product="Sop4p" /protein_id="DAA08615.1" /db_xref="SGD:S000003728" /translation="MFSQIVLLLSAFIYVASATARRGTIKGRLDLAASNITGFVSTRT SFKLYQIGNFSTEYPYTSTTMFQDDEGNFEFANLPLNDGVNETTYYVMYPASMDFNLK PNRILIEFKNLENGTLQLNAFKNFFGREYFPSKDITYPEKLQSMKVHPYITVELLHKA PIRSYLQARNVSIFSTGIVGNILNSRWKLAGVITLIALVVFPIIVEKLDPETARAIRE EAKRKQREKYAAVASK" gene 73787..74611 /gene="RPS14B" /locus_tag="YJL191W" /gene_synonym="CRY2" mRNA join(73787..73796,74205..74611) /gene="RPS14B" /locus_tag="YJL191W" /gene_synonym="CRY2" /product="ribosomal 40S subunit protein S14B" CDS join(73787..73796,74205..74611) /gene="RPS14B" /locus_tag="YJL191W" /gene_synonym="CRY2" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:direct assay:GO:0070181 small ribosomal subunit rRNA binding [PMID:9858605]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:2277060]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15125836]" /note="Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication" /codon_start=1 /product="ribosomal 40S subunit protein S14B" /protein_id="DAA08616.1" /db_xref="SGD:S000003727" /translation="MANDLVQARDNSQVFGVARIYASFNDTFVHVTDLSGKETIARVT GGMKVKADRDESSPYAAMLAAQDVAAKCKEVGITAVHVKIRATGGTRTKTPGPGGQAA LRALARSGLRIGRIEDVTPVPSDSTRKKGGRRGRRL" gene complement(74910..75302) /gene="RPS22A" /locus_tag="YJL190C" /gene_synonym="RPS24" mRNA complement(74910..75302) /gene="RPS22A" /locus_tag="YJL190C" /gene_synonym="RPS24" /product="ribosomal 40S subunit protein S22A" CDS complement(74910..75302) /gene="RPS22A" /locus_tag="YJL190C" /gene_synonym="RPS24" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication" /codon_start=1 /product="ribosomal 40S subunit protein S22A" /protein_id="DAA08617.1" /db_xref="SGD:S000003726" /translation="MTRSSVLADALNAINNAEKTGKRQVLIRPSSKVIIKFLQVMQKH GYIGEFEYIDDHRSGKIVVQLNGRLNKCGVISPRFNVKIGDIEKWTANLLPARQFGYV ILTTSAGIMDHEEARRKHVSGKILGFVY" gene 75933..76474 /gene="RPL39" /locus_tag="YJL189W" /gene_synonym="RPL46" /gene_synonym="SPB2" mRNA join(75933..75938,76325..76474) /gene="RPL39" /locus_tag="YJL189W" /gene_synonym="RPL46" /gene_synonym="SPB2" /product="ribosomal 60S subunit protein L39" CDS join(75933..75938,76325..76474) /gene="RPL39" /locus_tag="YJL189W" /gene_synonym="RPL46" /gene_synonym="SPB2" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog" /codon_start=1 /product="ribosomal 60S subunit protein L39" /protein_id="DAA08618.1" /db_xref="SGD:S000003725" /translation="MAAQKSFRIKQKMAKAKKQNRPLPQWIRLRTNNTIRYNAKRRNW RRTKMNI" gene complement(76803..79262) /gene="SWE1" /locus_tag="YJL187C" /gene_synonym="WEE1" mRNA complement(76803..79262) /gene="SWE1" /locus_tag="YJL187C" /gene_synonym="WEE1" /product="tyrosine protein kinase SWE1" CDS complement(76803..79262) /gene="SWE1" /locus_tag="YJL187C" /gene_synonym="WEE1" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0000086 G2/M transition of mitotic cell cycle [PMID:8253069]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004713 protein tyrosine kinase activity [PMID:8253069]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802|PMID:10805747]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10805747|PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0044879 mitotic morphogenesis checkpoint signaling [PMID:8930890]" /experiment="EXISTENCE:genetic interaction:GO:0000320 re-entry into mitotic cell cycle [PMID:15107621]" /experiment="EXISTENCE:genetic interaction:GO:0010697 negative regulation of mitotic spindle pole body separation [PMID:8887667]" /experiment="EXISTENCE:genetic interaction:GO:0090154 positive regulation of sphingolipid biosynthetic process [PMID:26634277]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:8253069]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0010697 negative regulation of mitotic spindle pole body separation [PMID:8887667]" /experiment="EXISTENCE:mutant phenotype:GO:0040020 regulation of meiotic nuclear division [PMID:10619027]" /experiment="EXISTENCE:mutant phenotype:GO:0044879 mitotic morphogenesis checkpoint signaling [PMID:9744879]" /experiment="EXISTENCE:mutant phenotype:GO:0090154 positive regulation of sphingolipid biosynthetic process [PMID:26634277]" /note="Protein kinase that regulates the G2/M transition; negative regulator of the Cdc28p kinase; morphogenesis checkpoint kinase; positive regulator of sphingolipid biosynthesis via Orm2p; phosphorylates a tyrosine residue in the N-terminus of Hsp90 in a cell-cycle associated manner, thus modulating the ability of Hsp90 to chaperone a selected clientele; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate" /codon_start=1 /product="tyrosine protein kinase SWE1" /protein_id="DAA08619.1" /db_xref="SGD:S000003723" /translation="MSSLDEDEEDFEMLDTENLQFMGKKMFGKQAGEDESDDFAIGGS TPTNKLKFYPYSNNKLTRSTGTLNLSLSNTALSEANSKFLGKIEEEEEEEEEGKDEES VDSRIKRWSPFHENESVTTPITKRSAEKTNSPISLKQWNQRWFPKNDARTENTSSSSS YSVAKPNQSAFTSSGLVSKMSMDTSLYPAKLRIPETPVKKSPLVEGRDHKHVHLSSSK NASSSLSVSPLNFVEDNNLQEDLLFSDSPSSKALPSIHVPTIDSSPLSEAKYHAHDRH NNQTNILSPTNSLVTNSSPQTLHSNKFKKIKRARNSVILKNRELTNSLQQFKDDLYGT DENFPPPIIISSHHSTRKNPQPYQFRGRYDNDTDEEISTPTRRKSIIGATSQTHRESR PLSLSSAIVTNTTSAETHSISSTDSSPLNSKRRLISSNKLSANPDSHLFEKFTNVHSI GKGQFSTVYQVTFAQTNKKYAIKAIKPNKYNSLKRILLEIKILNEVTNQITMDQEGKE YIIDYISSWKFQNSYYIMTELCENGNLDGFLQEQVIAKKKRLEDWRIWKIIVELSLAL RFIHDSCHIVHLDLKPANVMITFEGNLKLGDFGMATHLPLEDKSFENEGDREYIAPEI ISDCTYDYKADIFSLGLMIVEIAANVVLPDNGNAWHKLRSGDLSDAGRLSSTDIHSES LFSDITKVDTNDLFDFERDNISGNSNNAGTSTVHNNSNINNPNMNNGNDNNNVNTAAT KNRLILHKSSKIPAWVPKFLIDGESLERIVRWMIEPNYERRPTANQILQTEECLYVEM TRNAGAIIQEDDFGPKPKFFI" gene 80155..81915 /gene="MNN5" /locus_tag="YJL186W" mRNA 80155..81915 /gene="MNN5" /locus_tag="YJL186W" /product="alpha-1,2-mannosyltransferase MNN5" CDS 80155..81915 /gene="MNN5" /locus_tag="YJL186W" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:9756928]" /experiment="EXISTENCE:mutant phenotype:GO:0000026 alpha-1,2-mannosyltransferase activity [PMID:9756928]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:9756928]" /note="Alpha-1,2-mannosyltransferase; responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment" /codon_start=1 /product="alpha-1,2-mannosyltransferase MNN5" /protein_id="DAA08620.2" /db_xref="SGD:S000003722" /translation="MLIRLKKRKILQVIVSAVVLILFFCSVHNDVSSSWLYGKKLRLP VLTRSNLKNNFYTTLVQAIVENKPADSSPDLSKLHGAEGCSFANNVAAHDSGHDSDLS YESLSKCYNLNKTVQESLREVHSKFTDTLSGKLNFSIPQREALFSGSEGIVTIGGGKY SVLAYTMIKKLRDTGTTLPIEVIIPPQDEGEDDFCKNWLPKFNGKCIYFSDIVPSKPL SDLKLTHFQLKVFGLIISSFKRIIFLDADNYAVKNLDLAFNTTSFNDTGLILWPDFWR RVTPPAFYNIIGSSINIGKRVRFVSDDISPVSRYDPFVSNSNDYTPKERQEHFLKHVP LHDLDGTMPDLSSESGQMVIDKIRHFNTLLLALYYNVYGPTWYYKMISQGTAGEGDKD TFVAAAHALNMPYYQVRTNFEFDGFFYQKDDYKGLALLQHDFEQDYKQYQKAQQKVKA NIEEFSKLDPDYTLDNGFLKTLMVNDDGSDLDIMFIHASFYKADPWTLYHENRFIGPN GEQVRGFRKPHRYGMDFELFLFNDMRGSFCTTPKSQVIKFKYFTDKVNTPEWDAMCEY LTNHVNYLESTHKEAMGEKN" gene complement(82095..82976) /gene="ATG36" /locus_tag="YJL185C" mRNA complement(82095..82976) /gene="ATG36" /locus_tag="YJL185C" /product="Atg36p" CDS complement(82095..82976) /gene="ATG36" /locus_tag="YJL185C" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:22643220]" /experiment="EXISTENCE:mutant phenotype:GO:0000423 mitophagy [PMID:29673596]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:22643220]" /experiment="EXISTENCE:physical interaction:GO:0000425 pexophagy [PMID:22643220]" /note="Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene" /codon_start=1 /product="Atg36p" /protein_id="DAA08621.1" /db_xref="SGD:S000003721" /translation="MASVNNYQVDCGSRSARIQPRINNGIHDEESLFEVLELSEEEFE LDFHRLKSFNDVRVINNPDLSPECTNTAISRDETLESASSAFEVPSDEIAILSISSDS NKNSPPSEQPAPALRNIRSSSNSDRIDEWCLGSHLFNELHQNVPQSSDGVNHGFPVYS FKERELYTSAKLKKLTNAQRIAVQKLSRDLYPILRTCYREKTRRQLLTYHHERIFDDI PSFFPQRDFIFNYYSMPLEFDRLSDVDIDSSSRSRFTDESTGETLNRSPSAASSSLEN TSWFGWTLLSRFLDREW" gene 83448..83819 /gene="GON7" /locus_tag="YJL184W" /gene_synonym="LDB6" /gene_synonym="PCC2" mRNA 83448..83819 /gene="GON7" /locus_tag="YJL184W" /gene_synonym="LDB6" /gene_synonym="PCC2" /product="chromatin DNA-binding EKC/KEOPS complex subunit GON7" CDS 83448..83819 /gene="GON7" /locus_tag="YJL184W" /gene_synonym="LDB6" /gene_synonym="PCC2" /experiment="EXISTENCE:direct assay:GO:0000408 EKC/KEOPS complex [PMID:16564010|PMID:16874308]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:16874308]" /experiment="EXISTENCE:direct assay:GO:0031490 chromatin DNA binding [PMID:16874308]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]" /experiment="EXISTENCE:mutant phenotype:GO:0000032 cell wall mannoprotein biosynthetic process [PMID:14734024]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:16564010]" /experiment="EXISTENCE:physical interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16874308]" /note="Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; implicated in osmotic stress response; other complex members are Kae1p, Cgi121p, Pcc1p, and Bud32p" /codon_start=1 /product="chromatin DNA-binding EKC/KEOPS complex subunit GON7" /protein_id="DAA08622.1" /db_xref="SGD:S000003720" /translation="MKLPVAQYSAPDGVEKSFAPIRDDPRYMTTEGRTTGPSDHVLNA GQIDRDKPSEPERTKDGSQLTYLGQLRTQLTGLQDDINEFLTGRMELAKNKKKAGADE KRIQEEINQLLDGGDGDEDAV" gene 84068..85336 /gene="MNN11" /locus_tag="YJL183W" mRNA 84068..85336 /gene="MNN11" /locus_tag="YJL183W" /product="alpha-1,6-mannosyltransferase" CDS 84068..85336 /gene="MNN11" /locus_tag="YJL183W" /experiment="EXISTENCE:direct assay:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:10635561]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006486 protein glycosylation [PMID:10635561]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:10635561]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:23210626]" /experiment="EXISTENCE:physical interaction:GO:0000136 mannan polymerase complex [PMID:9430634]" /note="Subunit of a Golgi mannosyltransferase complex; this complex also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p" /codon_start=1 /product="alpha-1,6-mannosyltransferase" /protein_id="DAA08623.2" /db_xref="SGD:S000003719" /translation="MAIKPRTKGKTYSSRSVGSQWFNRLGFKQNKYGTCKFLSIITAF VFILYFFSNRFYPISRSAGASYSPSHGLYINEIPASSRLIYPHVEHVPVLKQMTVRGL YITRLEVDGSKRLILKPEENALTDEEKKKTTDQILLVKHSFLDHGKLVYRKSNDAPEV VVVTLIDFENYELETIIQIVQNRVDYAQKHQYGVYIRWIQEFLPVLENQNLAESYEFI KPLVIRAAMHAFPTAKYIHFVDQDALLMNLDLSLQKYLLDPKIMDLALLKNVPVVANS NIKTYNHFEYSSAKIIIPHDADGNIDASSFVIANDFYGKALIDYLNDPLLRNFPWDNT GDKLSAAIGHILQWHPTLLGKTAIVIPKVLASQYDASLDQEGESGNGASNGDVYHYNE GDLAASFKGCRSRGTCASEIGHMYQKIKKS" gene 85660..87495 /gene="RBH1" /locus_tag="YJL181W" mRNA 85660..87495 /gene="RBH1" /locus_tag="YJL181W" /product="Rbh1p" CDS 85660..87495 /gene="RBH1" /locus_tag="YJL181W" /note="hypothetical protein; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; contains a PH-like domain; RBH1 has a paralog, RBH2, that arose from the whole genome duplication" /codon_start=1 /product="Rbh1p" /protein_id="DAA08624.1" /db_xref="SGD:S000003717" /translation="MEIFKEEEEEAFSAIEGIIYACEVYDPVPRHLHKSKTKIINAAK LIIETHLSYYTILNNISDIQAYLSTWLRDLGTTGPYQTILSESISLMFDRTVSIFRKC TIEGGFPHLIARLYLRLKSYQKLLNDAGLKNFFSSYDYAFGVAYNLVNCSEYRYDEVH YISNGTYSLVASMKIDPAEVIKREHFRLTIPKFNISNILIEIFHLLDGLAFFKVNPDS LSISTASAETIFRSISEGNHQVLELGRSLMFPLLRTGDFEICRIDDAGAVITFTEAKD VKLEIISLDEVSWVMQWKSCLQNYERRAANDSSFIKTHLQFKKANNFNEDNNGLGLIV DRNIPTDDFTLASTNRQSPPPSNTGCSLHRSKPLHIPLSSVIREDFYDSSLNERISKD GDSSCESFSGAESILSDYDFHDNEFFNNQSPHYFSEHIDNNSREVVITDENTIISLEN TQVSRWSNYSWQKISPHQLQVSIIQLRMGNFIVAYDSDYNLHQFKIRLCDDIKCIQST EQDIQIRVPLGAIMCSVTGILNIRTKDADKLLRVLSFYTTDHTEAVSHSNNQDATASP LSSVSSAMDLKHSLQKCSSTIMPQELTQDVIGSKSDLISNIRQKI" gene complement(87583..88560) /gene="ATP12" /locus_tag="YJL180C" mRNA complement(87583..88560) /gene="ATP12" /locus_tag="YJL180C" /product="ATP synthase complex assembly protein ATP12" CDS complement(87583..88560) /gene="ATP12" /locus_tag="YJL180C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:1826907]" /experiment="EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:2142305]" /experiment="EXISTENCE:physical interaction:GO:0019904 protein domain specific binding [PMID:10747017]" /experiment="EXISTENCE:physical interaction:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:10747017]" /note="Assembly factor for F1 sector of mitochondrial F1F0 ATP synthase; conserved protein; required for assembly of alpha and beta subunits into F1 sector of mitochondrial F1F0 ATP synthase; human homolog ATPAF2 can complement yeast atp12 mutant; mutation of human homolog reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency" /codon_start=1 /product="ATP synthase complex assembly protein ATP12" /protein_id="DAA08625.1" /db_xref="SGD:S000003716" /translation="MLPSLRKGCFIVNSIRLKLPRFYSLNAQPLGTDNTIENNTPTET NRLSKTSQKFWEKVSLNRDVEKGKIALQLDGRTIKTPLGNGIIVDNAKSLLAYLLKLE WSSLSSLSIKTHSLPLTSLVARCIDLQMTNEPGCDPQLVAKIGGNSDVIKNQLLRYLD TDTLLVFSPMNEFEGRLRNAQNELYIPIIKGMEEFLRNFSSESNIRLQILDADIHGLR GNQQSDIVKNAAKKYMSSLSPWDLAILEKTVLTTKSFICGVLLLENKKDTANLIPALK TDMDNIVRAATLETIFQVEKWGEVEDTHDVDKRDIRRKIHTAAIAAFKQ" gene 88787..89116 /gene="PFD1" /locus_tag="YJL179W" /gene_synonym="GIM6" mRNA 88787..89116 /gene="PFD1" /locus_tag="YJL179W" /gene_synonym="GIM6" /product="prefolding complex chaperone subunit" CDS 88787..89116 /gene="PFD1" /locus_tag="YJL179W" /gene_synonym="GIM6" /experiment="EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:9630229]" /experiment="EXISTENCE:mutant phenotype:GO:0007010 cytoskeleton organization [PMID:9630229]" /experiment="EXISTENCE:mutant phenotype:GO:0016272 prefoldin complex [PMID:9630229]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:9630229]" /note="Subunit of heterohexameric prefoldin; prefoldin binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation" /codon_start=1 /product="prefolding complex chaperone subunit" /protein_id="DAA08626.2" /db_xref="SGD:S000003715" /translation="MSQIAQEMTVSLRNARTQLDMVNQQLAYLDRQEKLAELTKKELE SYPTDKVWRSCGKSFILQDKSKYVNDLSHDETVLLDQRKTLKIKKNYLETTVEKTIDN LKALMKN" gene complement(89282..90097) /gene="ATG27" /locus_tag="YJL178C" /gene_synonym="ETF1" mRNA complement(89282..90097) /gene="ATG27" /locus_tag="YJL178C" /gene_synonym="ETF1" /product="Atg27p" CDS complement(89282..90097) /gene="ATG27" /locus_tag="YJL178C" /gene_synonym="ETF1" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:17135291]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17135291]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:25557545]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:16107716]" /experiment="EXISTENCE:direct assay:GO:0016236 macroautophagy [PMID:25557545]" /experiment="EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:33817564]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:12186856]" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:17135291]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:17135291]" /experiment="EXISTENCE:mutant phenotype:GO:0016050 vesicle organization [PMID:12186856]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:17135291]" /experiment="EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:17135291]" /note="Type I membrane protein involved in autophagy and the Cvt pathway; targeted to vacuole via AP-3 pathway" /codon_start=1 /product="Atg27p" /protein_id="DAA08627.1" /db_xref="SGD:S000003714" /translation="MVSKTWICGFISIITVVQALSCEKHDVLKKYQVGKFSSLTSTER DTPPSTTIEKWWINVCEEHNVEPPEECKKNDMLCGLTDVILPGKDAITTQIIDFDKNI GFNVEETESALTLTLKGATWGANSFDAKLEFQCNDNMKQDELTSHTWADKSIQLTLKG PSGCLKSKDDDKKNGDGDNGKDGDSEGKKPAKKAGGTSWFTWLFLYALLFTLIYLMVV SFLNTRGGSFQDFRAEFIQRSTQFLTSLPEFCKEVVSRILGRSTAQRGGYSAV" gene 90786..91657 /gene="RPL17B" /locus_tag="YJL177W" mRNA join(90786..91094,91412..91657) /gene="RPL17B" /locus_tag="YJL177W" /product="ribosomal 60S subunit protein L17B" CDS join(90786..91094,91412..91657) /gene="RPL17B" /locus_tag="YJL177W" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23268442]" /experiment="EXISTENCE:genetic interaction:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:23268442]" /note="Ribosomal 60S subunit protein L17B; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication" /codon_start=1 /product="ribosomal 60S subunit protein L17B" /protein_id="DAA08628.1" /db_xref="SGD:S000003713" /translation="MARYGATSTNPAKSASARGSYLRVSFKNTRETAQAINGWELTKA QKYLDQVLDHQRAIPFRRFNSSIGRTAQGKEFGVTKARWPAKSVKFVQGLLQNAAANA EAKGLDATKLYVSHIQVNQAPKQRRRTYRAHGRINKYESSPSHIELVVTEKEEAVAKA AEKKVVRLTSRQRGRIAAQKRISA" gene complement(92053..94530) /gene="SWI3" /locus_tag="YJL176C" /gene_synonym="HAF2" /gene_synonym="TYE2" mRNA complement(92053..94530) /gene="SWI3" /locus_tag="YJL176C" /gene_synonym="HAF2" /gene_synonym="TYE2" /product="Swi3p" CDS complement(92053..94530) /gene="SWI3" /locus_tag="YJL176C" /gene_synonym="HAF2" /gene_synonym="TYE2" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:16461455]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:1339306|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:8016655]" /experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:8159677|PMID:8127913|PMID:8016655|PMID:18644858]" /experiment="EXISTENCE:mutant phenotype:GO:0003677 DNA binding [PMID:16461455]" /experiment="EXISTENCE:mutant phenotype:GO:0016514 SWI/SNF complex [PMID:8159677]" /experiment="EXISTENCE:mutant phenotype:GO:0031496 positive regulation of mating type switching [PMID:6436497]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:3542227|PMID:1339306]" /experiment="EXISTENCE:physical interaction:GO:0042393 histone binding [PMID:17496903]" /note="Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; contains SANT domain that is required for SWI/SNF assembly; is essential for displacement of histone H2A-H2B dimers during ATP-dependent remodeling; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions" /codon_start=1 /product="Swi3p" /protein_id="DAA08629.1" /db_xref="SGD:S000003712" /translation="MENTLGEGSTVNASVDVDQHGNDNNSDSNANAAVAGVANTDTAG EESQQQDESLKDEATVPNTRDAESEAITVTAKQQPTMQANKLDSQETPSTEESRAQNV FGQDNEDSDNLFGETESSVSNNEANTPSIPTNPVDNENNKPAIKEDSTIQDSNGDVKN MEDVKIQKEEEPENNTVIEGVKEESQPDENTKEMDEVEEDDEDDDQPMISPDNSIFGD TKSESKQLGNTSSVANTPSEIPDAHKAEQEDIIEKTESVDKKVDSGEERNEQEREIMN DHSKSANPKKTTITRVEPETFEIPQAHEIVIPSYSKWFNLEKIHSIEVQSLPEFFTNR IPSKTPEVYMRYRNFMVNSYRLNPNEYFSVTTARRNVSGDAAALFRLHKFLTKWGLIN YQVDSKLLPKNIEPPLTSQYSTRHDAPRGLFPFESYKPSVQLPDMAKLKKMMNTSDSE STLYKYLKESKRKYDEITHPPSTTDDENGDKNDNGGKMNNEVSTSTSMTGDANLLEEG ETSRPLKKVKILEQIDENWSKEDLQKLLKGIQEFGADWYKVAKNVGNKSPEQCILRFL QLPIEDKFLYGDGNGKGDNDNGLGPLKYAPHLPFSKSENPVLSTIAFLVGLVNPKTVQ SMTQRAIQSAESIKSQKEEISDQKPIEHIKEGSEIAISSLGYRSHIFATNEERQMNFL TNELIRLQMEKLDAKLNHLKKLEKFMELERKTLERQQENLLIQRLNFNQNSSKIVNVL SKCLNLISDSNINNSSVAEKEEIRSQIDHFKSMLSKPETLSIGKNPFNKPNIETGENH NGQSISNENDVKPISIEAPQFYRYWSA" gene 95092..95922 /gene="KRE9" /locus_tag="YJL174W" mRNA 95092..95922 /gene="KRE9" /locus_tag="YJL174W" /product="Kre9p" CDS 95092..95922 /gene="KRE9" /locus_tag="YJL174W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:8413233]" /experiment="EXISTENCE:mutant phenotype:GO:0006077 (1->6)-beta-D-glucan metabolic process [PMID:8413233]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:8413233]" /note="Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects" /codon_start=1 /product="Kre9p" /protein_id="DAA08630.1" /db_xref="SGD:S000003710" /translation="MRLQRNSIICALVFLVSFVLGDVNIVSPSSKATFSPSGGTVSVP VEWMDNGAYPSLSKISTFTFSLCTGPNNNIDCVAVLASKITPSELTQDDKVYSYTAEF ASTLTGNGQYYIQVFAQVDGQGYTIHYTPRFQLTSMGGVTAYTYSATTEPTPQTSIQT TTTNNAQATTIDSRSFTVPYTKQTGTSRFAPMQMQPNTKVTATTWTRKFATSAVTYYS TFGSLPEQATTITPGWSYTISSGVNYATPASMPSDNGGWYKPSKRLSLSARKINMRKV " gene complement(96161..96529) /gene="RFA3" /locus_tag="YJL173C" /gene_synonym="RPA14" /gene_synonym="RPA3" mRNA complement(96161..96529) /gene="RFA3" /locus_tag="YJL173C" /gene_synonym="RPA14" /gene_synonym="RPA3" /product="Rfa3p" CDS complement(96161..96529) /gene="RFA3" /locus_tag="YJL173C" /gene_synonym="RPA14" /gene_synonym="RPA3" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:9679065]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:7761422]" /experiment="EXISTENCE:direct assay:GO:0005662 DNA replication factor A complex [PMID:2554144]" /experiment="EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:22885009]" /experiment="EXISTENCE:direct assay:GO:0006268 DNA unwinding involved in DNA replication [PMID:2554144]" /experiment="EXISTENCE:direct assay:GO:0006289 nucleotide-excision repair [PMID:8910442]" /experiment="EXISTENCE:direct assay:GO:0030491 heteroduplex formation [PMID:12226081]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:7761422]" /experiment="EXISTENCE:genetic interaction:GO:0000724 double-strand break repair via homologous recombination [PMID:9679065]" /experiment="EXISTENCE:mutant phenotype:GO:0000781 chromosome, telomeric region [PMID:14702040]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:9093844]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:9093844]" /experiment="EXISTENCE:mutant phenotype:GO:0010833 telomere maintenance via telomere lengthening [PMID:22354040]" /experiment="EXISTENCE:physical interaction:GO:0000722 telomere maintenance via recombination [PMID:2554144]" /experiment="EXISTENCE:physical interaction:GO:0006312 mitotic recombination [PMID:2554144]" /experiment="EXISTENCE:physical interaction:GO:0007004 telomere maintenance via telomerase [PMID:2554144]" /experiment="EXISTENCE:physical interaction:GO:0007131 reciprocal meiotic recombination [PMID:2554144]" /experiment="EXISTENCE:physical interaction:GO:0016567 protein ubiquitination [PMID:18342608]" /experiment="EXISTENCE:physical interaction:GO:0045184 establishment of protein localization [PMID:2554144]" /note="Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="Rfa3p" /protein_id="DAA08631.1" /db_xref="SGD:S000003709" /translation="MASETPRVDPTEISNVNAPVFRIIAQIKSQPTESQLILQSPTIS SKNGSEVEMITLNNIRVSMNKTFEIDSWYEFVCRNNDDGELGFLILDAVLCKFKENED LSLNGVVALQRLCKKYPEIY" gene 97737..99467 /gene="CPS1" /locus_tag="YJL172W" mRNA 97737..99467 /gene="CPS1" /locus_tag="YJL172W" /product="Gly-Xaa carboxypeptidase" CDS 97737..99467 /gene="CPS1" /locus_tag="YJL172W" /EC_number="3.4.17.4" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:1569061]" /experiment="EXISTENCE:mutant phenotype:GO:0004180 carboxypeptidase activity [PMID:2026161]" /experiment="EXISTENCE:mutant phenotype:GO:0008152 metabolic process [PMID:2026161]" /experiment="EXISTENCE:mutant phenotype:GO:0051603 proteolysis involved in protein catabolic process [PMID:2026161]" /note="Vacuolar carboxypeptidase S; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via AP-3 pathway; expression induced under low-nitrogen conditions" /codon_start=1 /product="Gly-Xaa carboxypeptidase" /protein_id="DAA08632.1" /db_xref="SGD:S000003708" /translation="MIALPVEKAPRKSLWQRHRAFISGIVALIIIGTFFLTSGLHPAP PHEAKRPHHGKGPMHSPKCEKIEPLSPSFKHSVDTILHDPAFRNSSIEKLSNAVRIPT VVQDKNPNPADDPDFYKHFYELHDYFEKTFPNIHKHLKLEKVNELGLLYTWEGSDPDL KPLLLMAHQDVVPVNNETLSSWKFPPFSGHYDPETDFVWGRGSNDCKNLLIAEFEAIE QLLIDGFKPNRTIVMSLGFDEEASGTLGAASLASFLHERYGDDGIYSIIDEGEGIMEV DKDVFVATPINAEKGYVDFEVSILGHGGHSSVPPDHTTIGIASELITEFEANPFDYEF EFDNPIYGLLTCAAEHSKSLSKDVKKTILGAPFCPRRKDKLVEYISNQSHLRSLIRTT QAVDIINGGVKANALPETTRFLINHRINLHSSVAEVFERNIEYAKKIAEKYGYGLSKN GDDYIIPETELGHIDITLLRELEPAPLSPSSGPVWDILAGTIQDVFENGVLQNNEEFY VTTGLFSGNTDTKYYWNLSKNIYRFVGSIIDIDLLKTLHSVNEHVDVPGHLSAIAFVY EYIVNVNEYA" rep_origin 99458..99678 /note="ARS1006; Autonomously Replicating Sequence" /db_xref="SGD:S000028443" gene complement(99704..100894) /gene="TOH1" /locus_tag="YJL171C" mRNA complement(99704..100894) /gene="TOH1" /locus_tag="YJL171C" /product="Toh1p" CDS complement(99704..100894) /gene="TOH1" /locus_tag="YJL171C" /EC_number="3.2.1.39" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /note="GPI-anchored cell wall hypothetical protein; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="Toh1p" /protein_id="DAA08633.2" /db_xref="SGD:S000003707" /translation="MLQSIVLSVCMFMLHTVAASGPQSYQKLDFTNVGFTGSYVDVNK FKDITNNESCTCEVGDRVWFSGKNAPLADYLSVHFRGPLKLKQFAFYTSPGFTVNNSR SSSDWNRLAYYESSSKTADNVTFLNHGGEASPCLGNALSYASSNGTGSASEATVLADG TLISSDQEYIIYSNVSCPKSGYDKGCGVYRSGIPAYYGYGGTTKMFLFEFEMPTETEK NSSSIGYYDLPAIWLLNDHIARTSQYPTNANCSCWASGCGEYDIFEAMNGTEKNHLYS TFHTFQGIEDLGTGIQSYGYITRNTTGTMKGGVVFDSSGNVVSFISDATPFNGTVSAD TVNDLLAAIPENETYSSQLMSISATAPSTTSKSNGVALTKMQNGVWYYILAIFTAFTQ VVLI" gene complement(101150..101779) /gene="ASG7" /locus_tag="YJL170C" mRNA complement(101150..101779) /gene="ASG7" /locus_tag="YJL170C" /product="Asg7p" CDS complement(101150..101779) /gene="ASG7" /locus_tag="YJL170C" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11073983]" /experiment="EXISTENCE:expression pattern:GO:0000747 conjugation with cellular fusion [PMID:10568744]" /note="Protein that regulates signaling from G protein beta subunit Ste4p; contributes to relocalization of Ste4p within the cell; specific to a-cells and induced by alpha-factor" /codon_start=1 /product="Asg7p" /protein_id="DAA08634.1" /db_xref="SGD:S000003706" /translation="MTTLASSIEHKTKHLAAPFENDENPWMKKYCCQCKSCKMSVPVQ PWLPRFFVFGILCPVFWLVNLLAWWFLQYWQPHELEFHDLQEDEYPGFYEYEAITKRT VIPIKEEVLQEIRVMQNFSDSNSEEYYESKDGMPSSFLNVNTEQVEDENDTLKKYRYA FLKKVAHDVLESHDLLRKTFRDWNLRSLLGLLIDSILIIFVVLLCKKSR" gene complement(102227..104428) /gene="SET2" /locus_tag="YJL168C" /gene_synonym="EZL1" /gene_synonym="KMT3" mRNA complement(102227..104428) /gene="SET2" /locus_tag="YJL168C" /gene_synonym="EZL1" /gene_synonym="KMT3" /product="histone methyltransferase SET2" CDS complement(102227..104428) /gene="SET2" /locus_tag="YJL168C" /gene_synonym="EZL1" /gene_synonym="KMT3" /EC_number="2.1.1.359" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:28483910]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006354 DNA-templated transcription elongation [PMID:12736296]" /experiment="EXISTENCE:direct assay:GO:0006355 regulation of DNA-templated transcription [PMID:11839797]" /experiment="EXISTENCE:direct assay:GO:0046975 histone H3K36 methyltransferase activity [PMID:11839797]" /experiment="EXISTENCE:mutant phenotype:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:35263330]" /experiment="EXISTENCE:mutant phenotype:GO:0006353 DNA-templated transcription termination [PMID:23109428]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:11839797]" /experiment="EXISTENCE:mutant phenotype:GO:0009302 sno(s)RNA transcription [PMID:23109428]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:19417103]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:17150765]" /experiment="EXISTENCE:mutant phenotype:GO:0045128 negative regulation of reciprocal meiotic recombination [PMID:18515193]" /experiment="EXISTENCE:mutant phenotype:GO:0046975 histone H3K36 methyltransferase activity [PMID:11839797]" /experiment="EXISTENCE:mutant phenotype:GO:0060195 negative regulation of antisense RNA transcription [PMID:21248844]" /note="Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for their deacetylation within transcribed genes; involved in transcription coupled-nucleotide excision repair; associates with C-terminal domain (CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to cytosol in response to hypoxia" /codon_start=1 /product="histone methyltransferase SET2" /protein_id="DAA08635.2" /db_xref="SGD:S000003704" /translation="MSKNQSVSASEDEKEILNNNAEGHKPQRLFDQEPDLTEEALTKF ENLDDCIYANKRIGTFKNNDFMECDCYEEFSDGVNHACDEDSDCINRLTLIECVNDLC SSCGNDCQNQRFQKKQYAPIAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVIEEMEFR DRLIDYDQRHFKHFYFMMLQNGEFIDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRM GIFAQRKILKGEEITFDYNVDRYGAQAQKCYCEEPNCIGFLGGKTQTDAASLLPQNIA DALGVTVSMEKKWLKLKKLSGEPIIKNENENINIEFLQSLEVQPIDSPVDVTKIMSVL LQQDNKIIASKLLKRLFTIDDDSLRHQAIKLHGYTCFSKMLKLFITEQPQVDGKGNET EEDDIKFIKGILDFLLELPKTTRNGIESSQIDNVVKTLPAKFPFLKPNCDELLEKWSK FETYKRITKKDINVAASKMIDLRRVRLPPGWEIIHENGRPLYYNAEQKTKLHYPPSGS SKVFSSRSNTQVNSPSSSGIPKTPGALDSKKHKLSDEEYERKKQKRLEYERIALERAK QEELESLKQKLKLENERKSVLEDIIAEANKQKELQKEEAKKLVEAKEAKRLKRKTVSQ SQRLEHNWNKFFASFVPNLIKKNPQSKQFDHENIKQCAKDIVKILTTKELKKDSSRAP PDDLTKGKRHKVKEFINSYMDKIILKKKQKKALALSSASTRMSSPPPSTSS" gene 105014..106072 /gene="ERG20" /locus_tag="YJL167W" /gene_synonym="BOT3" /gene_synonym="FDS1" /gene_synonym="FPP1" mRNA 105014..106072 /gene="ERG20" /locus_tag="YJL167W" /gene_synonym="BOT3" /gene_synonym="FDS1" /gene_synonym="FPP1" /product="bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase" CDS 105014..106072 /gene="ERG20" /locus_tag="YJL167W" /gene_synonym="BOT3" /gene_synonym="FDS1" /gene_synonym="FPP1" /EC_number="2.5.1.1" /EC_number="2.5.1.10" /experiment="EXISTENCE:direct assay:GO:0004161 dimethylallyltranstransferase activity [PMID:2681213]" /experiment="EXISTENCE:direct assay:GO:0004337 (2E,6E)-farnesyl diphosphate synthase activity [PMID:2681213]" /experiment="EXISTENCE:direct assay:GO:0004452 isopentenyl-diphosphate delta-isomerase activity [PMID:7908830]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19416104]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:19416104]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:7908830]" /experiment="EXISTENCE:direct assay:GO:0008299 isoprenoid biosynthetic process [PMID:2681213]" /experiment="EXISTENCE:direct assay:GO:0045337 farnesyl diphosphate biosynthetic process [PMID:2681213]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:1779710]" /note="Farnesyl pyrophosphate synthetase; has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis" /codon_start=1 /product="bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase" /protein_id="DAA08636.1" /db_xref="SGD:S000003703" /translation="MASEKEIRRERFLNVFPKLVEELNASLLAYGMPKEACDWYAHSL NYNTPGGKLNRGLSVVDTYAILSNKTVEQLGQEEYEKVAILGWCIELLQAYFLVADDM MDKSITRRGQPCWYKVPEVGEIAINDAFMLEAAIYKLLKSHFRNEKYYIDITELFHEV TFQTELGQLMDLITAPEDKVDLSKFSLKKHSFIVTFKTAYYSFYLPVALAMYVAGITD EKDLKQARDVLIPLGEYFQIQDDYLDCFGTPEQIGKIGTDIQDNKCSWVINKALELAS AEQRKTLDENYGKKDSVAEAKCKKIFNDLKIEQLYHEYEESIAKDLKAKISQVDESRG FKADVLTAFLNKVYKRSK" gene 106434..106718 /gene="QCR8" /locus_tag="YJL166W" /gene_synonym="COR5" mRNA 106434..106718 /gene="QCR8" /locus_tag="YJL166W" /gene_synonym="COR5" /product="ubiquinol--cytochrome-c reductase subunit 8" CDS 106434..106718 /gene="QCR8" /locus_tag="YJL166W" /gene_synonym="COR5" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0045275 respiratory chain complex III [PMID:10873857]" /experiment="EXISTENCE:mutant phenotype:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:8394810]" /experiment="EXISTENCE:mutant phenotype:GO:0008121 ubiquinol-cytochrome-c reductase activity [PMID:8786239]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:8394810]" /note="Subunit 8 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p" /codon_start=1 /product="ubiquinol--cytochrome-c reductase subunit 8" /protein_id="DAA08637.1" /db_xref="SGD:S000003702" /translation="MGPPSGKTYMGWWGHMGGPKQKGITSYAVSPYAQKPLQGIFHNA VFNSFRRFKSQFLYVLIPAGIYWYWWKNGNEYNEFLYSKAGREELERVNV" gene complement(106894..109461) /gene="HAL5" /locus_tag="YJL165C" mRNA complement(106894..109461) /gene="HAL5" /locus_tag="YJL165C" /product="protein kinase HAL5" CDS complement(106894..109461) /gene="HAL5" /locus_tag="YJL165C" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:32191698]" /experiment="EXISTENCE:genetic interaction:GO:0008104 protein localization [PMID:21237705]" /experiment="EXISTENCE:mutant phenotype:GO:0030003 intracellular monoatomic cation homeostasis [PMID:10207057]" /experiment="EXISTENCE:mutant phenotype:GO:0045807 positive regulation of endocytosis [PMID:32191698]" /note="Snf1p-related nutrient-responsive protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication" /codon_start=1 /product="protein kinase HAL5" /protein_id="DAA08638.1" /db_xref="SGD:S000003701" /translation="MGDEKLSRHTSLKRARSLSESIKGLFKPSGISGSNNAAAPSSRP GQDQAHSHQTARIITSNVSSPSISPVHSPVLQAAPKHHKLGVPNIAKLSLSPSREPSL NSENEMFSQESFISEKDEDEANLLEREDLQNKKEEKARAKHVRSKEAYVPHHRYTVGS DEVERQPRERLKNFPQNAGSSNPANSNANHVLDQENNFSIDAMLDYDEESKLRRRNSL GVRNHSNRTRSRKNSLSTPRSPPMKNGNGGMNSNATNNVGNGTGNRIYMRGRNHSDSI SASSLPKFQEIECKCILDLGHFKVFENGYHEHSLRVLPIITNNKNVDSGDEKDADASV NSGDDGDNDSEANMHKQKSVFSLSGLFKSHKDGNQQQQQQQQQEENGEQINLEKAFSI IPSQRFIKSQTLKKSRTSNLKNGNNDELMKNDGKNIPQIVNPNAAVGVEELKLINALS EKIRKGLKSENTKGNNGEGRSNSNKQEDSDDTEGKAGTTNDDTSHKPCSQKYGKSIGV VGAGAYGVVKICARCKTAKDVLPYSTYSNGKKLFFAVKELKPKPGDQIDKFCTRLTSE FIIGHSLSHPHFEANAMIAGNVSRTTPPKHVFNAPNILKILDLMEYSNSFVEVMEFCA SGDLYSLLTRNNISNESNNGSSRLIQTVKEGSGSPLHPLEADCFMKQLLNGVQYMHDH GIAHCDLKPENILFQPNGLLKICDFGTSSVFQTAWEKHVHFQSGAMGSEPYVAPEEFI RDAEYDPRLVDCWSCGIVYCTMVMGQYLWKIAIPEKDSLFKSFLSEIKDDGQFYLFEE LRHVSSELNRLRKIALYRTFQVDPTKRITIEQLLQSSWMRKTKCCVVYRHLHTKVSK" gene complement(109966..111159) /gene="TPK1" /locus_tag="YJL164C" /gene_synonym="PKA1" /gene_synonym="SRA3" mRNA complement(109966..111159) /gene="TPK1" /locus_tag="YJL164C" /gene_synonym="PKA1" /gene_synonym="SRA3" /product="cAMP-dependent protein kinase catalytic subunit TPK1" CDS complement(109966..111159) /gene="TPK1" /locus_tag="YJL164C" /gene_synonym="PKA1" /gene_synonym="SRA3" /EC_number="2.7.11.11" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:26403272]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004691 cAMP-dependent protein kinase activity [PMID:34244791|PMID:3036373]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10625697]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10625697]" /experiment="EXISTENCE:direct assay:GO:0005952 cAMP-dependent protein kinase complex [PMID:12024012]" /experiment="EXISTENCE:direct assay:GO:0018105 peptidyl-serine phosphorylation [PMID:34244791]" /experiment="EXISTENCE:genetic interaction:GO:0004691 cAMP-dependent protein kinase activity [PMID:3036373]" /experiment="EXISTENCE:genetic interaction:GO:0005952 cAMP-dependent protein kinase complex [PMID:3036373]" /experiment="EXISTENCE:genetic interaction:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:34244791|PMID:33008596]" /experiment="EXISTENCE:genetic interaction:GO:0007265 Ras protein signal transduction [PMID:3036373]" /experiment="EXISTENCE:genetic interaction:GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly [PMID:21925385]" /experiment="EXISTENCE:genetic interaction:GO:0010737 protein kinase A signaling [PMID:20133652]" /experiment="EXISTENCE:mutant phenotype:GO:0004691 cAMP-dependent protein kinase activity [PMID:3036373]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:34244791|PMID:33008596]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:34244791]" /experiment="EXISTENCE:mutant phenotype:GO:0007265 Ras protein signal transduction [PMID:2823100]" /experiment="EXISTENCE:mutant phenotype:GO:0016241 regulation of macroautophagy [PMID:15016820]" /experiment="EXISTENCE:mutant phenotype:GO:0018105 peptidyl-serine phosphorylation [PMID:34244791]" /experiment="EXISTENCE:physical interaction:GO:0005952 cAMP-dependent protein kinase complex [PMID:12024012]" /note="cAMP-dependent protein kinase catalytic subunit; role in nutrient-stimulated growth via Ras-cAMP signaling; inhibited by regulatory subunit Bcy1p in cAMPs absence; phosphorylates and inhibits Whi3p to promote G1/S phase passage; phosphorylates Nej1p to regulate nonhomologous end joining (NHEJ); impairs mitochondrial import of pre-Tom40p via phosphorylation under non-respiratory conditions; partially redundant with Tpk2p and Tpk3p; human homolog PRKACB regulates NHEJ via NHEJ1 phosphorylation" /codon_start=1 /product="cAMP-dependent protein kinase catalytic subunit TPK1" /protein_id="DAA08639.2" /db_xref="SGD:S000003700" /translation="MSTEEQNGGGQKSLDDRQGEESQKGETSERETTATESGNESKSV EKEGGETQEKPKQPHVTYYNEEQYKQFIAQARVTSGKYSLQDFQILRTLGTGSFGRVH LIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQI FMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILL DKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEML AGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTED VKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDKYPEEDINYGVQGEDPYAD LFRDF" gene complement(111666..113333) /locus_tag="YJL163C" mRNA complement(111666..113333) /locus_tag="YJL163C" /product="hypothetical protein" CDS complement(111666..113333) /locus_tag="YJL163C" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08640.1" /db_xref="SGD:S000003699" /translation="MSNEDETTRLMSSDEMDYLLETAGINALEEIISQNDSTGINLDT NETAQDSSYDSIRRSPSILSVAKSVEGEHGRRKLLCLYGLVMIICIAESISMTATIPL VMDKVAEGISDENGHYDSVAVQTIVSSISSSTMMIAGAISIFMAGKWGELSDRIGRVR VFKYMSGIRVIGLLTHVFTLSSKMKYHKWAIVLTACIVPSFGGLFALVANGNSYVSDI VKTEHRMVTIGIMMSCIYATMGVGPMFGSFLVKWTHGNGFIPIYTSIAFVILALIICE TIMVEPRHETQMAHSQSTYTKRREKLRSQSGSDDARNYQSVTYGKFQIMRLMDLLAPV KKLWLKPDSAGSLVPRHTVILLIVLDILFVCGTTSCMPALILFSTYEYKWHAVELGYF ISILGIGRGVVLLVVSPTLLYTLKRIYQHLNHSIDKIDIFCIQFSMIVITLSLFVMIR FGEKTPTSMIIFALLQALSAFCSPTLQSGIIKYTSKKHTGEMFGAMALVRSCVMLVIP PILLKLYGSTVSVNPSLFMYIPFSTSIVAILLTFFLRIYKNPPLDGP" rep_origin 113678..113749 /note="ARS1007; Autonomously Replicating Sequence" /db_xref="SGD:S000028444" gene complement(113878..115629) /gene="JJJ2" /locus_tag="YJL162C" mRNA complement(113878..115629) /gene="JJJ2" /locus_tag="YJL162C" /product="Jjj2p" CDS complement(113878..115629) /gene="JJJ2" /locus_tag="YJL162C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; contains a J-domain, which is a region with homology to the E. coli DnaJ protein" /codon_start=1 /product="Jjj2p" /protein_id="DAA08641.1" /db_xref="SGD:S000003698" /translation="MSQVIEPQLDRTTYYSILGLTSNATSSEVHKSYLKLARLLHPDK TKSDKSEELFKAVVHAHSILTDEDQKLRYDRDLKIKGLHTYQPKKNCHIFKTKAKESQ GASPTLGQSEAYHRQNKPYEQQPYGFGVGKKMTSSSKSKVPIFKSFNLKSYQRNHYYS SKKERKHGSPDIDSLFHETNGASKVRMTDAGKMDTNSQFQEIWEILGKNAYTHKSYSE DPNSCLGSALSDHEEEEEAGKQQQQQQQQQQQQQHYGMTSKSSSPDEEKKNNKEPKRE SRVSPEENGEEETGHKQFKLPKTSTFSSGSHDSNLQSPFYNHEYRHYARSKFECKNQF RKSVSPIKEIPATTSANEGWNILRDIIEKLNISNVDDRNKDLLFRRDEIGDKNHSDSI DIENLSIKEPKGMKRRKKDDISLEELFQSLPREKDYFMMDAINDSLESINLFKKPKTT QSHEQGGTFAQAESNRAKFKPLLEQCGITPEILDLEIPEIPEFDAVADLETLKLNVQL FNNQCNKLKETIHQVSLQRLRADTQFSDMLTQKQSIMVWKTYLEFDKSLMDKLNILQE RQMQVIKIFSERCDGKV" gene complement(115939..116010) /locus_tag="YNCJ0002C" tRNA complement(115939..116010) /locus_tag="YNCJ0002C" /product="tRNA-Glu" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Glutamate tRNA (tRNA-Glu), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p; target of K. lactis zymocin" /db_xref="SGD:S000006557" gene 117245..117787 /gene="FMP33" /locus_tag="YJL161W" mRNA 117245..117787 /gene="FMP33" /locus_tag="YJL161W" /product="Fmp33p" CDS 117245..117787 /gene="FMP33" /locus_tag="YJL161W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:14562095]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /codon_start=1 /product="Fmp33p" /protein_id="DAA08642.1" /db_xref="SGD:S000003697" /translation="MLYTRLLRHNSQFTKFSGTSPNLGSKPLFSKGNLYTSLLVTTLY GTGLACLYLESNSLNKSKEQEDPHAIAEDDIVNIVHDAPNRIFKPALDTYQEKELDLQ KSDLHKVLHSLTYSDVSQFSIVWGFLIQLSSLIGNSTLGKKSILYKGSVVSVLGFPPL IYMALKLRMKQLEKAGVRFE" gene complement(117962..118825) /gene="PIR5" /locus_tag="YJL160C" mRNA complement(117962..118825) /gene="PIR5" /locus_tag="YJL160C" /product="beta-1,3-glucan linked protein" CDS complement(117962..118825) /gene="PIR5" /locus_tag="YJL160C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="hypothetical protein; member of the PIR (Proteins with Internal Repeats) family of cell wall proteins; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, and mCherry fusion localizes to the vacuole; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication" /codon_start=1 /product="beta-1,3-glucan linked protein" /protein_id="DAA08643.1" /db_xref="SGD:S000003696" /translation="MHYKKAFLASLLSSIALTAYAPPEPWATLTPSSKMDGGTTEYRT SFGLAVIPFTVTESKVKRNVISQINDGQVQVTTQKLPHPVSQIGDGQIQVTTQKVPPV VSHIVSQIGDGQLQITTAKNVVTKSTIAVPSKTVTATATSTATAVSQIHDGQVQVTIS SASSSSVLSKSKLEPTKKPNNEKVIKVQACKSSGTLAITLQGGVLIDSSGRIGSIVAN RQFQFDGPPPQAGAIYAGGWSITKHGTLAIGDNDVFYQCLSGTFYNLYDQSIGGQCNP VHLQTVGLVDC" gene 120449..121690 /gene="HSP150" /locus_tag="YJL159W" /gene_synonym="CCW7" /gene_synonym="ORE1" /gene_synonym="PIR2" mRNA 120449..121690 /gene="HSP150" /locus_tag="YJL159W" /gene_synonym="CCW7" /gene_synonym="ORE1" /gene_synonym="PIR2" /product="heat shock protein HSP150" CDS 120449..121690 /gene="HSP150" /locus_tag="YJL159W" /gene_synonym="CCW7" /gene_synonym="ORE1" /gene_synonym="PIR2" /experiment="EXISTENCE:direct assay:GO:0005199 structural constituent of cell wall [PMID:10209754]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:19129178]" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:16278454]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10209754|PMID:9192695|PMID:15781460]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:21446055]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:21446055]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10407261]" /note="O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication" /codon_start=1 /product="heat shock protein HSP150" /protein_id="DAA08644.1" /db_xref="SGD:S000003695" /translation="MQYKKTLVASALAATTLAAYAPSEPWSTLTPTATYSGGVTDYAS TFGIAVQPISTTSSASSAATTASSKAKRAASQIGDGQVQAATTTASVSTKSTAAAVSQ IGDGQIQATTKTTAAAVSQIGDGQIQATTKTTSAKTTAAAVSQISDGQIQATTTTLAP KSTAAAVSQIGDGQVQATTTTLAPKSTAAAVSQIGDGQVQATTKTTAAAVSQIGDGQV QATTKTTAAAVSQIGDGQVQATTKTTAAAVSQIGDGQVQATTKTTAAAVSQITDGQVQ ATTKTTQAASQVSDGQVQATTATSASAAATSTDPVDAVSCKTSGTLEMNLKGGILTDG KGRIGSIVANRQFQFDGPPPQAGAIYAAGWSITPDGNLAIGDNDVFYQCLSGTFYNLY DEHIGSQCTPVHLEAIDLIDC" gene complement(122265..122948) /gene="CIS3" /locus_tag="YJL158C" /gene_synonym="CCW11" /gene_synonym="CCW5" /gene_synonym="PIR4" /gene_synonym="SCW8" mRNA complement(122265..122948) /gene="CIS3" /locus_tag="YJL158C" /gene_synonym="CCW11" /gene_synonym="CCW5" /gene_synonym="PIR4" /gene_synonym="SCW8" /product="Cis3p" CDS complement(122265..122948) /gene="CIS3" /locus_tag="YJL158C" /gene_synonym="CCW11" /gene_synonym="CCW5" /gene_synonym="PIR4" /gene_synonym="SCW8" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:12702350|PMID:19129178]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:10438739]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10438739|PMID:15781460]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10407261]" /note="Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family" /codon_start=1 /product="Cis3p" /protein_id="DAA08645.1" /db_xref="SGD:S000003694" /translation="MQFKNVALAASVAALSATASAEGYTPGEPWSTLTPTGSISCGAA EYTTTFGIAVQAITSSKAKRDVISQIGDGQVQATSAATAQATDSQAQATTTATPTSSE KISSSASKTSTNATSSSCATPSLKDSSCKNSGTLELTLKDGVLTDAKGRIGSIVANRQ FQFDGPPPQAGAIYAAGWSITEDGYLALGDSDVFYQCLSGNFYNLYDQNVAEQCSAIH LEAVSLVDC" gene complement(123836..126328) /gene="FAR1" /locus_tag="YJL157C" mRNA complement(123836..126328) /gene="FAR1" /locus_tag="YJL157C" /product="cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1" CDS complement(123836..126328) /gene="FAR1" /locus_tag="YJL157C" /experiment="EXISTENCE:direct assay:GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity [PMID:8066461]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9822386|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:9822386]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:14988725]" /experiment="EXISTENCE:direct assay:GO:0120171 Cdc24p-Far1p-Gbetagamma complex [PMID:10087263]" /experiment="EXISTENCE:mutant phenotype:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:7490290|PMID:10087263]" /experiment="EXISTENCE:mutant phenotype:GO:0000751 mitotic cell cycle G1 arrest in response to pheromone [PMID:2147873]" /experiment="EXISTENCE:mutant phenotype:GO:0043577 chemotropism [PMID:7490290|PMID:10087263]" /experiment="EXISTENCE:mutant phenotype:GO:0051457 maintenance of protein location in nucleus [PMID:10655592]" /experiment="EXISTENCE:physical interaction:GO:0120171 Cdc24p-Far1p-Gbetagamma complex [PMID:10087263]" /note="CDK inhibitor and nuclear anchor; during the cell cycle Far1p sequesters the GEF Cdc24p in the nucleus; phosphorylation by Cdc28p-Cln results in SCFCdc4 complex-mediated ubiquitin-dependent degradation, releasing Cdc24p for export and activation of GTPase Cdc42p; in response to pheromone, phosphorylation of Far1p by MAPK Fus3p results in association with, and inhibition of Cdc28p-Cln, as well as Msn5p mediated nuclear export of Far1p-Cdc24p, targeting Cdc24p to polarity sites" /codon_start=1 /product="cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1" /protein_id="DAA08646.1" /db_xref="SGD:S000003693" /translation="MKTPTRVSFEKKIHTPPSGDRDAERSPPKKFLRGLSGKVFRKTP EFKKQQMPTFGYIEESQFTPNLGLMMSKRGNIPKPLNLSKPISPPPSLKKTAGSVASG FSKTGQLSALQSPVNITSSNKYNIKATNLTTSLLRESISDSTTMCDTLSDINLTVMDE DYRIDGDSYYEEDSPTFMISLERNIKKCNSQFSPKRYIGEKCLICEESISSTFTGEKV VESTCSHTSHYNCYLMLFETLYFQGKFPECKICGEVSKPKDKDIVPEMVSKLLTGAGA HDDGPSSNMQQQWIDLKTARSFTGEFPQFTPQEQLIRTADISCDGFRTPRLSNSNQFE AVSYLDSPFLNSPFVNKMATTDPFDLSDDEKLDCDDEIDESAAEVWFSKTGGEHVMVS VKFQEMRTSDDLGVLQDVNHVDHEELEEREKEWKKKIDQYIETNVDKDSEFGSLILFD KLMYSDDGEQWVDNNLVILFSKFLVLFDFEEMKILGKIPRDQFYQVIKFNEDVLLCSL KSTNIPEIYLRFNENCEKWLLPKWKYCLENSSLETLPLSEIVSTVKELSHVNIIGALG APPDVISAQSHDSRLPWKRLHSDTPLKLIVCLNLSHADGELYRKRVLKSVHQILDGLN TDDLLGIVVVGRDGSGVVGPFGTFIGMINKNWDGWTTFLDNLEVVNPNVFRDEKQQYK VTLQTCERLASTSAYVDTDDHIATGYAKQILVLNGSDVVDIEHDQKLKKAFDQLSYHW RYEISQRRMTPLNASIKQFLEELHTKRYLDVTLRLPQATFEQVYLGDMAAGEQKTRLI MDEHPHSSLIEIEYFDLVKQQRIHQTLEVPNL" gene complement(126853..128952) /gene="SSY5" /locus_tag="YJL156C" /gene_synonym="RAA3" mRNA complement(126853..128952) /gene="SSY5" /locus_tag="YJL156C" /gene_synonym="RAA3" /product="Ssy5p" CDS complement(126853..128952) /gene="SSY5" /locus_tag="YJL156C" /gene_synonym="RAA3" /experiment="EXISTENCE:direct assay:GO:0004252 serine-type endopeptidase activity [PMID:29661936|PMID:16778074]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11154269]" /experiment="EXISTENCE:direct assay:GO:0016485 protein processing [PMID:16778074]" /experiment="EXISTENCE:genetic interaction:GO:0043200 response to amino acid [PMID:11154269]" /experiment="EXISTENCE:mutant phenotype:GO:0004252 serine-type endopeptidase activity [PMID:16524914]" /experiment="EXISTENCE:mutant phenotype:GO:0016485 protein processing [PMID:16524914]" /experiment="EXISTENCE:mutant phenotype:GO:0016540 protein autoprocessing [PMID:29661936]" /experiment="EXISTENCE:mutant phenotype:GO:0043200 response to amino acid [PMID:11154269]" /note="Serine protease of SPS plasma membrane amino acid sensor system; contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p; other members are Ssy1p and Ptr3p" /codon_start=1 /product="Ssy5p" /protein_id="DAA08647.1" /db_xref="SGD:S000003692" /translation="MVRFFGLNKKKNEEKENTDLPADNEQNAAETSSSNVSGNEERID PNSHDTNPENANNDDASTTFGSSIQSSSIFSRGRMTYGTGASSSMATSEMRSHSSGHS GSKNSKNLQGFKDVGKPLRAVSFLSPVKEEESQDTQNTLDVSSSTSSTLATSENAREN SFTSRRSITLEYIHKSLSELEENLVDIMDDIHQDVISISKAVIEAIEYFKEFLPTTRD RIPYRISLEKSSSLRKINKIVLHFLDNLLVSDAFSNSRSILLRRFYFFLKKLNLITDD DLISESGVLPCLSVFCIGSHCNLPSMDKLGMILDELTKMDSSIISDQEGAFIAPILRG ITPKSSILTIMFGLPNLQHEHYEMIKVLYSLFPDVHMYCVKDYIKKAASAVGSIPSHT AATIDTIAPTKFQFSPPYAVSENPLELPISMSLSTETSAKITGTLGGYLFPQTGSDKK FSQFASCSFAITCAHVVLSEKQDYPNVMVPSNVLQTSYKKVLTKESDRYPDGSVEKTA FLEEVQRIDQNLNWQKSNKFGQVVWGERAIVDHRLSDFAIIKVNSSFKCQNTLGNGLK SFPDPTLRFQNLHVKRKIFKMKPGMKVFKIGASTGYTSGELNSTKLVYWADGKLQSSE FVVASPTPLFASAGDSGAWILTKLEDRLGLGLVGMLHSYDGEQRQFGLFTPIGDILER LHAVTKIQWDIDPQLDG" gene complement(129285..130643) /gene="FBP26" /locus_tag="YJL155C" mRNA complement(129285..130643) /gene="FBP26" /locus_tag="YJL155C" /product="fructose-2,6-bisphosphatase" CDS complement(129285..130643) /gene="FBP26" /locus_tag="YJL155C" /EC_number="3.1.3.46" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity [PMID:1322693]" /experiment="EXISTENCE:mutant phenotype:GO:0006006 glucose metabolic process [PMID:1322693]" /note="Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="fructose-2,6-bisphosphatase" /protein_id="DAA08648.1" /db_xref="SGD:S000003691" /translation="MGYSTISNDNDIKVCVIMVGLPARGKSFISQKIIRYLSWLSIKA KCFNVGNYRRDVSGNVPMDAEFFNFENTDNFKLRELAAQNAIKDIVNFFTKEDGSVAV FDATNSTRKRRKWLKDICEKNNIQPMFLESWSNDHELIINNAKDIGSTSPDYENSEPH VAEADFLERIRQYERFYEPLDPQKDKDMTFIKLVNIIEEVVINKIRTYLESRIVFYVM NIRPKPKYIWLSRHGESIYNVEKKIGGDSSLSERGFQYAKKLEQLVKESAGEINLTVW TSTLKRTQQTANYLPYKKLQWKALDELDAGVCDGMTYEEIEKEYPEDFKARDNDKYEY RYRGGESYRDVVIRLEPVIMELERQENVLIITHQAVLRCIYAYFMNVPQEESPWMSIP LHTLIKLEPRAYGTKVTKIKANIPAVSTYKEKGTSQVGELSQSSTKLHQLLNDSPLED KF" gene complement(131101..133935) /gene="VPS35" /locus_tag="YJL154C" /gene_synonym="ENV1" /gene_synonym="GRD9" /gene_synonym="VPT7" mRNA complement(131101..133935) /gene="VPS35" /locus_tag="YJL154C" /gene_synonym="ENV1" /gene_synonym="GRD9" /gene_synonym="VPT7" /product="retromer subunit VPS35" CDS complement(131101..133935) /gene="VPS35" /locus_tag="YJL154C" /gene_synonym="ENV1" /gene_synonym="GRD9" /gene_synonym="VPT7" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22593205]" /experiment="EXISTENCE:mutant phenotype:GO:0030904 retromer complex [PMID:9700157]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:8649377]" /experiment="EXISTENCE:mutant phenotype:GO:0140312 cargo adaptor activity [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0005768 endosome [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0030906 retromer, cargo-selective complex [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0140312 cargo adaptor activity [PMID:9700157]" /note="Endosomal subunit of membrane-associated retromer complex; required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p; overexpression of wild-type human VPS35 or Parkinson's-associated vps35-D686N or vps35-P299S variants complements Ni2+ resistance and Cd2+ sensitivity of yeast vps35 null mutant" /codon_start=1 /product="retromer subunit VPS35" /protein_id="DAA08649.1" /db_xref="SGD:S000003690" /translation="MAYADSPENAIAVIKQRTALMNRCLSQHKLMESLQHTSIMLTEL RNPNLSPKKYYELYVIIFDSLTNLSTYLIENHPQNHHLADLYELVQYTGNVVPRLYLM ITVGTSYLTFNEAPKKEILKDMIEMCRGVQNPIRGLFLRYYLSQRTKELLPEDDPSFN SQFIMNNFIEMNKLWVRLQHQGPLRERETRTRERKELQILVGSQLVRLSQIIDDNFQM YKQDILPTILEQVIQCRDLVSQEYLLDVICQVFADEFHLKTLDTLLQTTLHLNPDVSI NKIVLTLVDRLNDYVTRQLEDDPNATSTNAYLDMDVFGTFWDYLTVLNHERPDLSLQQ FIPLVESVIVLSLKWYPNNFDNLNKLFELVLQKTKDYGQKNISLESEHLFLVLLSFQN SKLQLTSSTTAPPNSPVTSKKHFIFQLISQCQAYKNILALQSISLQKKVVNEIIDILM DREVEEMADNDSESKLHPPGHSAYLVIEDKLQVQRLLSICEPLIISRSGPPANVASSD TNVDEVFFNRHDEEESWILDPIQEKLAHLIHWIMNTTSRKQTMKNKIQFSLEAQLEIL LLIKSSFIKGGINVKYTFPAIITNFWKLMRKCRMIQEYLLKKRPDNKTLLSHYSNLLK QMFKFVSRCINDIFNSCNNSCTDLILKLNLQCAILADQLQLNEISYDFFSQAFTIFEE SLSDSKTQLQALIYIAQSLQKTRSLYKEAYYDSLIVRCTLHGSKLLKKQDQCRAVYLC SHLWWATEISNIGEEEGITDNFYRDGKRVLECLQRSLRVADSIMDNEQSCELMVEILN RCLYYFIHGDESETHISIKYINGLIELIKTNLKSLKLEDNSASMITNSISDLHITGEN NVKASSNADDGSVITDKESNVAIGSDGTYIQLNTLNGSSTLIRGVVATASGSKLLHQL KYIPIHHFRRTCEYIESQREVDDRFKVIYV" gene complement(134332..135933) /gene="INO1" /locus_tag="YJL153C" /gene_synonym="APR1" mRNA complement(134332..135933) /gene="INO1" /locus_tag="YJL153C" /gene_synonym="APR1" /product="inositol-3-phosphate synthase INO1" CDS complement(134332..135933) /gene="INO1" /locus_tag="YJL153C" /gene_synonym="APR1" /EC_number="5.5.1.4" /experiment="EXISTENCE:direct assay:GO:0004512 inositol-3-phosphate synthase activity [PMID:7016881]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006021 inositol biosynthetic process [PMID:7016881]" /note="Inositol-3-phosphate synthase; involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element" /codon_start=1 /product="inositol-3-phosphate synthase INO1" /protein_id="DAA08650.1" /db_xref="SGD:S000003689" /translation="MTEDNIAPITSVKVVTDKCTYKDNELLTKYSYENAVVTKTASGR FDVTPTVQDYVFKLDLKKPEKLGIMLIGLGGNNGSTLVASVLANKHNVEFQTKEGVKQ PNYFGSMTQCSTLKLGIDAEGNDVYAPFNSLLPMVSPNDFVVSGWDINNADLYEAMQR SQVLEYDLQQRLKAKMSLVKPLPSIYYPDFIAANQDERANNCINLDEKGNVTTRGKWT HLQRIRRDIQNFKEENALDKVIVLWTANTERYVEVSPGVNDTMENLLQSIKNDHEEIA PSTIFAAASILEGVPYINGSPQNTFVPGLVQLAEHEGTFIAGDDLKSGQTKLKSVLAQ FLVDAGIKPVSIASYNHLGNNDGYNLSAPKQFRSKEISKSSVIDDIIASNDILYNDKL GKKVDHCIVIKYMKPVGDSKVAMDEYYSELMLGGHNRISIHNVCEDSLLATPLIIDLL VMTEFCTRVSYKKVDPVKEDAGKFENFYPVLTFLSYWLKAPLTRPGFHPVNGLNKQRT ALENFLRLLIGLPSQNELRFEERLL" gene complement(136372..136773) /gene="SNA3" /locus_tag="YJL151C" mRNA complement(136372..136773) /gene="SNA3" /locus_tag="YJL151C" /product="Sna3p" CDS complement(136372..136773) /gene="SNA3" /locus_tag="YJL151C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:22761830|PMID:23708375]" /experiment="EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:12499386|PMID:17182850]" /experiment="EXISTENCE:direct assay:GO:0031625 ubiquitin protein ligase binding [PMID:17332499|PMID:17182849]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:19944104]" /experiment="EXISTENCE:mutant phenotype:GO:0031625 ubiquitin protein ligase binding [PMID:17182849|PMID:17332499]" /experiment="EXISTENCE:mutant phenotype:GO:0032509 endosome transport via multivesicular body sorting pathway [PMID:22212814]" /experiment="EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:17332499|PMID:17182849]" /note="Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles" /codon_start=1 /product="Sna3p" /protein_id="DAA08651.1" /db_xref="SGD:S000003687" /translation="MDRDHINDHDHRMSYSINKDDLLLMVLAVFIPPVAVWKRKGMFN RDTLLNLLLFLLLFFPAIIHACYVVYETSSERSYDLSRRHATAPAVDRDLEAHPAEES QAQPPAYDEDDEAGADVPLMDNKQQLSSGRT" gene 137379..139370 /gene="DAS1" /locus_tag="YJL149W" /gene_synonym="DUH1" mRNA 137379..139370 /gene="DAS1" /locus_tag="YJL149W" /gene_synonym="DUH1" /product="SCF ubiquitin ligase complex subunit DAS1" CDS 137379..139370 /gene="DAS1" /locus_tag="YJL149W" /gene_synonym="DUH1" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994|PMID:11283612]" /experiment="EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994]" /note="Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C" /codon_start=1 /product="SCF ubiquitin ligase complex subunit DAS1" /protein_id="DAA08652.1" /db_xref="SGD:S000003685" /translation="MPFQDYFQKKKAAFINRNNKSNADASALRDINDININFAAKSKN YVFPLTKLPDELMQEVFSHLPQPDRLQLCLVNKRLNKIATKLLYRRIYLNDSNVVKSD FMHLAINWTLLNLPSSLKEEESRDIANCKLKKLIETLQNNIHITEVIQWIRINWDLDS TLQRSILSILCNQGKSLQRLENVTDPACNDIISNGHFSRSNVSSFDMAPPNSLPEMVV PENYIPNLTKYLSQRISSRLSHMTLFIDPLKLFNYLYPLDIKLQIIDLKLHWRREFYN NDYFVKKIRPGNPLTKLSEVFDKRTLKILTIISWNDTLLKRETEMLKDFKEFENLEDL SLISIKQDVHILVDLFSSLTNLKRLKMDFLEEYVPEPTNPHIFLSILLACSKLQFIDL RYDGLIPQIINIQENKFQLNQQCNCTNCQIVFSDILKGKIFMFPEDYYIHDLQDIAAK DIFKMMKYLSLLPYSKACDAYPSVRTQPMNLTNFVTKMNRNLLEYRNSKSQLVPKIVN NPHQHSTVTSTSTAHMSEPEMIIIDDDDDDDEINAAIPPSSDDTAATISTDLELPHES LTKRDIIMCYHALIHHFKSIYVTFLKSFPHLRFLMLNDIPTIVMEENNERIFEPVFYH YDYKSNLYGWSKESNKNLENDSNNNNNNSDTIARIATVM" gene complement(139566..139691) /gene="SNR128" /locus_tag="YNCJ0003C" ncRNA complement(139566..139691) /ncRNA_class="snoRNA" /gene="SNR128" /locus_tag="YNCJ0003C" /product="SNR128" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:2850487]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22266655|PMID:31804585]" /experiment="EXISTENCE:direct assay:GO:0031428 box C/D methylation guide snoRNP complex [PMID:10094313]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:7557394]" /experiment="EXISTENCE:genetic interaction:GO:0019843 rRNA binding [PMID:7557394]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:7557394|PMID:2406561]" /experiment="EXISTENCE:mutant phenotype:GO:0019843 rRNA binding [PMID:7557394]" /experiment="EXISTENCE:physical interaction:GO:0031428 box C/D methylation guide snoRNP complex [PMID:10733567|PMID:11081632]" /note="C/D box small nucleolar RNA (snoRNA); referred to as U14; essential gene required for cleavage of 35S primary rRNA transcript to release the precursor to the 18S rRNA; guides 2'-O-methylation of small subunit (SSU) rRNA at position C414" /db_xref="SGD:S000006508" gene complement(139761..139950) /gene="SNR190" /locus_tag="YNCJ0004C" ncRNA complement(139761..139950) /ncRNA_class="snoRNA" /gene="SNR190" /locus_tag="YNCJ0004C" /product="SNR190" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:2850487]" /experiment="EXISTENCE:direct assay:GO:0031428 box C/D methylation guide snoRNP complex [PMID:10094313]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:34686656]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:34686656]" /experiment="EXISTENCE:mutant phenotype:GO:0140691 RNA folding chaperone [PMID:34686656]" /experiment="EXISTENCE:physical interaction:GO:0031428 box C/D methylation guide snoRNP complex [PMID:11081632|PMID:10733567]" /note="C/D box small nucleolar RNA (snoRNA); predicted to guide 2'-O-methylation of large subunit (LSU) rRNA at position G2395; not shown to be active" /db_xref="SGD:S000006509" gene 140437..141138 /gene="RPA34" /locus_tag="YJL148W" /gene_synonym="CST21" mRNA 140437..141138 /gene="RPA34" /locus_tag="YJL148W" /gene_synonym="CST21" /product="DNA-directed RNA polymerase I subunit RPA34" CDS 140437..141138 /gene="RPA34" /locus_tag="YJL148W" /gene_synonym="CST21" /experiment="EXISTENCE:direct assay:GO:0001054 RNA polymerase I activity [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12206772]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12206772]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969|PMID:9121426]" /experiment="EXISTENCE:direct assay:GO:0006362 transcription elongation by RNA polymerase I [PMID:18160037]" /experiment="EXISTENCE:genetic interaction:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:9121426]" /experiment="EXISTENCE:mutant phenotype:GO:0005736 RNA polymerase I complex [PMID:9121426]" /note="RNA polymerase I subunit A34.5; essential for nucleolar assembly and for high polymerase loading rate; nucleolar localization depends on Rpa49p" /codon_start=1 /product="DNA-directed RNA polymerase I subunit RPA34" /protein_id="DAA08653.1" /db_xref="SGD:S000003684" /translation="MSKLSKDYVSDSDSDDEVISNEFSIPDGFKKCKHLKNFPLNGDN KKKAKQQQVWLIKFPSNVDISKLKSLPVDFESSTTMTIDKHDYKIMDDTDIESSLTQD NLSNMTLLVPSESKESLKIASTAKDNAPLQFDKVFSVSETAKIPAIDYSKVRVPRKDV PKVEGLKLEHFATGYDAEDFHVAEEVKENKKEPKKRSHHDDEEESSEKKKKKKEKREK REKKDKKDKKKKHRD" gene complement(141419..142567) /gene="SMT1" /locus_tag="YJL147C" /gene_synonym="MRX5" mRNA complement(141419..142567) /gene="SMT1" /locus_tag="YJL147C" /gene_synonym="MRX5" /product="Smt1p" CDS complement(141419..142567) /gene="SMT1" /locus_tag="YJL147C" /gene_synonym="MRX5" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="Translational repressor of the mitochondrial ATP6/8 mRNA; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage" /codon_start=1 /product="Smt1p" /protein_id="DAA08654.1" /db_xref="SGD:S000003683" /translation="MRRTFSQLATRLLKSKDDELKSTLKYLTKGPVKLLGPLFESSEV NEQGSLLNRSRTKENNLQNHHIENILRILNSNLPEVESKKQKVAVHYDVLFSHLNSIV TQATDNKSSSSKELQGSSSEDLYDRLLLLQYVGKLTNVRQITEILLSKKFNKFDKVWE HRALFDEYQRVVISILLYYRTHDVQIRKDYEPRWLSDYSDLPFPLRRLLWRCLTSNVS EDNIRQNIIHYIKLLGANWRNNDLILIYQSLYEKSHILPDLTVLNHNKDDGFSFTQNQ ILLVRILRAISKCVEEEPKLVKKWLIDIVKLSIQSKIMLESPKKPSTPIMDQYKFIRS LDISIRSIHRTCQDKLIFEDLQVNLGSVLKMINEEEHELKTHLPLNLI" gene 143292..144701 /gene="IDS2" /locus_tag="YJL146W" mRNA 143292..144701 /gene="IDS2" /locus_tag="YJL146W" /product="Ids2p" CDS 143292..144701 /gene="IDS2" /locus_tag="YJL146W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0051087 protein-folding chaperone binding [PMID:30516470]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:7565676]" /experiment="EXISTENCE:mutant phenotype:GO:0061077 chaperone-mediated protein folding [PMID:30516470]" /note="Protein involved in modulation of Ime2p activity during meiosis; appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation" /codon_start=1 /product="Ids2p" /protein_id="DAA08655.1" /db_xref="SGD:S000003682" /translation="MDNQQESISEDITGDLAAAVRKSWSESQDNPLLLNFNNSPIGTP TDRYSPEPATMMEGNAMNLSSLARGSTQQQQRLYGSSQTREKSDQQQQDYQLFKHHYS LGQETRESVSDILNDLTLGSPEPSERASPIRQPSVDVPPLTTRRSSIQDVQWIRHLLN PRSSFSGASSNEPTNSPGDFLNQSRAWITILHDSSAESLQAVIVLAESLKNVNSQYNL WVLHSSEVNAFQLAQVGIKTLIIDEYINLFMNFGTGSGFSASSQSTETKGELNFKWCK LFLFFSLIDRFELICYLSPTCLVLQNIDELLESTEVSDEIDNETCVLLSNKVNYINED LVSVNQDQSSAENYDDDPQIIILKPNRAVAMCIKEYFTIYGNDFEGESKRSMFHQMND LQIMKALFGDKWSYIDSVGYCAVPIASVPANRLNYKIIEFKILKPWERQNYIAAGQHR ESIMNKWLDLWRDFLNQAN" gene 145160..146044 /gene="SFH5" /locus_tag="YJL145W" mRNA 145160..146044 /gene="SFH5" /locus_tag="YJL145W" /product="Sfh5p" CDS 145160..146044 /gene="SFH5" /locus_tag="YJL145W" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12869188|PMID:19477927]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19477927]" /experiment="EXISTENCE:direct assay:GO:0008526 phosphatidylinositol transfer activity [PMID:10848624]" /experiment="EXISTENCE:direct assay:GO:0015914 phospholipid transport [PMID:10848624]" /experiment="EXISTENCE:direct assay:GO:0020037 heme binding [PMID:32780017]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:16262726]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762|PMID:12869188]" /experiment="EXISTENCE:genetic interaction:GO:0017157 regulation of exocytosis [PMID:19477927]" /experiment="EXISTENCE:genetic interaction:GO:0043001 Golgi to plasma membrane protein transport [PMID:10848624]" /experiment="EXISTENCE:genetic interaction:GO:0046488 phosphatidylinositol metabolic process [PMID:16262726]" /experiment="EXISTENCE:genetic interaction:GO:2000114 regulation of establishment of cell polarity [PMID:19477927]" /note="Unusual phosphatidylinositol transfer protein (PITP) that binds heme; similar to Sec14p; founding member of conserved class of fungal hemoproteins; exhibits PI- but not PC-transfer activity; localizes to peripheral endoplasmic reticulum, cytosol, and microsomes; partially relocalizes to plasma membrane upon DNA replication stress" /codon_start=1 /product="Sfh5p" /protein_id="DAA08656.1" /db_xref="SGD:S000003681" /translation="MKFDNDSEKQVFDKLKKAIPGIIKEKCAGYDELYGYKLNPEGLT QEEVDKYYDEKIADRLTYKLCKAYQFEYSTIVQNLIDILNWRREFNPLSCAYKEVHNT ELQNVGILTFDANGDANKKAVTWNLYGQLVKKKELFQNVDKFVRYRIGLMEKGLSLLD FTSSDNNYMTQVHDYKGVSVWRMDSDIKNCSKTVIGIFQKYYPELLYAKYFVNVPTVF GWVYDLIKKFVDETTRKKFVVLTDGSKLGQYLKDCPYEGYGGKDKKNNLTKQNVTNVH PTEYGLYILQKQIIEDVE" gene 146359..146673 /gene="ROQ1" /locus_tag="YJL144W" mRNA 146359..146673 /gene="ROQ1" /locus_tag="YJL144W" /product="Roq1p" CDS 146359..146673 /gene="ROQ1" /locus_tag="YJL144W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:29861160]" /experiment="EXISTENCE:mutant phenotype:GO:0042631 cellular response to water deprivation [PMID:21420397]" /experiment="EXISTENCE:mutant phenotype:GO:0055106 ubiquitin-protein transferase regulator activity [PMID:29861160]" /experiment="EXISTENCE:mutant phenotype:GO:0120174 stress-induced homeostatically regulated protein degradation pathway [PMID:29861160]" /experiment="EXISTENCE:physical interaction:GO:0033554 cellular response to stress [PMID:29861160]" /experiment="EXISTENCE:physical interaction:GO:0055106 ubiquitin-protein transferase regulator activity [PMID:29861160]" /note="Ub-ligase substrate-specificity factor; proteolytically-cleaved form acts as a pseudosubstrate, binding and altering the substrate specificity of Ubr1p towards misfolded and native ER membrane and cytosolic proteins, as part of the stress-induced homeostatically regulated protein degradation (SHRED) pathway; hydrophilin essential during desiccation-rehydration; induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="Roq1p" /protein_id="DAA08657.1" /db_xref="SGD:S000003680" /translation="MLRRETSTIYRTHKKSNSSILRSQRDQTRVDSLVEESPMGDFGI NNQPTQPGVIYYFVELTNLGIQENTSSNNNNNNNHGDDENGSRYGHGSSLGGDVHSRR CS" gene 147101..147577 /gene="TIM17" /locus_tag="YJL143W" /gene_synonym="MIM17" /gene_synonym="MPI2" /gene_synonym="SMS1" mRNA 147101..147577 /gene="TIM17" /locus_tag="YJL143W" /gene_synonym="MIM17" /gene_synonym="MPI2" /gene_synonym="SMS1" /product="protein transporter TIM17" CDS 147101..147577 /gene="TIM17" /locus_tag="YJL143W" /gene_synonym="MIM17" /gene_synonym="MPI2" /gene_synonym="SMS1" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005744 TIM23 mitochondrial import inner membrane translocase complex [PMID:15618217]" /experiment="EXISTENCE:genetic interaction:GO:0000002 mitochondrial genome maintenance [PMID:18826960]" /experiment="EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:15618217|PMID:11344168]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:7600576|PMID:15618217|PMID:11344168|PMID:7919535]" /experiment="EXISTENCE:physical interaction:GO:0005744 TIM23 mitochondrial import inner membrane translocase complex [PMID:7600576]" /note="Essential core component of the TIM23 protein translocase complex; forms the protein translocation path with Mgr2p, while Tim23p contributes to the architecture of the import channel; may link the import motor to the core translocase of the inner mitochondrial membrane (TIM23 complex)" /codon_start=1 /product="protein transporter TIM17" /protein_id="DAA08658.1" /db_xref="SGD:S000003679" /translation="MSADHSRDPCPIVILNDFGGAFAMGAIGGVVWHGIKGFRNSPLG ERGSGAMSAIKARAPVLGGNFGVWGGLFSTFDCAVKAVRKREDPWNAIIAGFFTGGAL AVRGGWRHTRNSSITCACLLGVIEGVGLMFQRYAAWQAKPMAPPLPEAPSSQPLQA" gene complement(147819..148211) /gene="IRC9" /locus_tag="YJL142C" mRNA complement(147819..148211) /gene="IRC9" /locus_tag="YJL142C" /product="Irc9p" CDS complement(147819..148211) /gene="IRC9" /locus_tag="YJL142C" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:18085829]" /experiment="EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:23357952]" /note="hypothetical protein; partially overlaps verified gene YAK1/YJL141C but does not share all phenotypes; null mutant displays increased levels of spontaneous Rad52p foci, increased sporulation efficiency, and small defect in vacuolar fragmentation" /codon_start=1 /product="Irc9p" /protein_id="DAD54805.1" /db_xref="SGD:S000003678" /translation="MTMQKASKVNMEVRTTLVTMQATTMSIILALPLVVLIASTLVLS VKGRRIHLATSPIILLLLILFKKGQQARSINFTLSKNKSLFCLTFLNYPFHFITAWCH NDILNKYEFCLFLIFLIRIVITINKVTL" gene complement(147967..150390) /gene="YAK1" /locus_tag="YJL141C" mRNA complement(147967..150390) /gene="YAK1" /locus_tag="YJL141C" /product="serine/threonine protein kinase YAK1" CDS complement(147967..150390) /gene="YAK1" /locus_tag="YJL141C" /EC_number="2.7.12.1" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:21255108]" /experiment="EXISTENCE:direct assay:GO:0004713 protein tyrosine kinase activity [PMID:21255108]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11358866|PMID:21255108]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11358866|PMID:21255108]" /experiment="EXISTENCE:genetic interaction:GO:0141156 cAMP/PKA signal transduction [PMID:8065298]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:21255108]" /experiment="EXISTENCE:mutant phenotype:GO:0004713 protein tyrosine kinase activity [PMID:21255108]" /note="Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose" /codon_start=1 /product="serine/threonine protein kinase YAK1" /protein_id="DAA08659.1" /db_xref="SGD:S000003677" /translation="MNSSNNNDSSSSNSNMNNSLSPTLVTHSDASMGSGRASPDNSHM GRGIWNPSYVNQGSQRSPQQQHQNHHQQQQQQQQQQQQNSQFCFVNPWNEEKVTNSQQ NLVYPPQYDDLNSNESLDAYRRRKSSLVVPPARAPAPNPFQYDSYPAYTSSNTSLAGN SSGQYPSGYQQQQQQVYQQGAIHPSQFGSRFVPSLYDRQDFQRRQSLAATNYSSNFSS LNSNTNQGTNSIPVMSPYRRLSAYPPSTSPPLQPPFKQLRRDEVQGQKLSIPQMQLCN SKNDLQPVLNATPKFRRASLNSKTISPLVSVTKSLITTYSLCSPEFTYQTSKNPKRVL TKPSEGKCNNGFDNINSDYILYVNDVLGVEQNRKYLVLDILGQGTFGQVVKCQNLLTK EILAVKVVKSRTEYLTQSITEAKILELLNQKIDPTNKHHFLRMYDSFVHKNHLCLVFE LLSNNLYELLKQNKFHGLSIQLIRTFTTQILDSLCVLKESKLIHCDLKPENILLCAPD KPELKIIDFGSSCEEARTVYTYIQSRFYRAPEIILGIPYSTSIDMWSLGCIVAELFLG IPIFPGASEYNQLTRIIDTLGYPPSWMIDMGKNSGKFMKKLAPEESSSSTQKHRMKTI EEFCREYNIVEKPSKQYFKWRKLPDIIRNYRYPKSIQNSQELIDQEMQNRECLIHFLG GVLNLNPLERWTPQQAMLHPFITKQEFTGEWFPPGSSLPGPSEKHDDAKGQQSEYGSA NDSSNNAGHNYVYNPSSATGGADSVDIGAISKRKENTSGDISNNFAVTHSVQEGPTSA FNKLHIVEE" gene 150961..151626 /gene="RPB4" /locus_tag="YJL140W" /gene_synonym="CTF15" mRNA 150961..151626 /gene="RPB4" /locus_tag="YJL140W" /gene_synonym="CTF15" /product="DNA-directed RNA polymerase II subunit RPB4" CDS 150961..151626 /gene="RPB4" /locus_tag="YJL140W" /gene_synonym="CTF15" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:16357218]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:11087726]" /experiment="EXISTENCE:direct assay:GO:0003727 single-stranded RNA binding [PMID:11087726]" /experiment="EXISTENCE:direct assay:GO:0003968 RNA-dependent RNA polymerase activity [PMID:18004386]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12857861]" /experiment="EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:2186966|PMID:1331084|PMID:2183013]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12857861]" /experiment="EXISTENCE:direct assay:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:11087726]" /experiment="EXISTENCE:mutant phenotype:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:16357218]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:11577101]" /experiment="EXISTENCE:mutant phenotype:GO:0045948 positive regulation of translational initiation [PMID:21074047]" /experiment="EXISTENCE:physical interaction:GO:0031369 translation initiation factor binding [PMID:21074047]" /note="RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation" /codon_start=1 /product="DNA-directed RNA polymerase II subunit RPB4" /protein_id="DAA08660.1" /db_xref="SGD:S000003676" /translation="MNVSTSTFQTRRRRLKKVEEEENAATLQLGQEFQLKQINHQGEE EELIALNLSEARLVIKEALVERRRAFKRSQKKHKKKHLKHENANDETTAVEDEDDDLD EDDVNADDDDFMHSETREKELESIDVLLEQTTGGNNKDLKNTMQYLTNFSRFRDQETV GAVIQLLKSTGLHPFEVAQLGSLACDTADEAKTLIPSLNNKISDDELERILKELSNLE TLY" gene complement(151713..152999) /gene="YUR1" /locus_tag="YJL139C" mRNA complement(151713..152999) /gene="YUR1" /locus_tag="YJL139C" /product="mannosyltransferase YUR1" CDS complement(151713..152999) /gene="YUR1" /locus_tag="YJL139C" /experiment="EXISTENCE:direct assay:GO:0000030 mannosyltransferase activity [PMID:8631921]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:8631921]" /experiment="EXISTENCE:mutant phenotype:GO:0000032 cell wall mannoprotein biosynthetic process [PMID:8631921]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:8631921]" /note="Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication" /codon_start=1 /product="mannosyltransferase YUR1" /protein_id="DAA08661.1" /db_xref="SGD:S000003675" /translation="MAKGGSLYIVGIFLPIWTFMIYIFGKELFLIRKYQKIDSTYTAL SQRVKEQYDTSRRRNYFPKVKLSRNSYDDYTLNYTRQNDSDSFHLRENATILMLVRNS ELEGALDSMRSLEDRFNNKYHYDWTFLNDVPFDQDFIEATTSMASGKTQYALIPPEDW NRPQWINDTLFEERLRVMEDEGVLYGGSKSYRNMCRFNSGFFFRQSILDNYDYYFRVE PNVKYYCDFPYDPFRVMRLKGKKYGFVISLYEYEETIPTLWDAVEEYLVASEETILRK EDSAYAFLTDSGLVGKHYPVVEANSDYNLCHFWSNFEIGDLNFFRSDEYKHFFETLDA KGGFYYERWGDAPVHSIGVSLLLRPDEIIHFDELGYFHSPFGTCPASYAVRLDQRCRC KSDDESVIDITPHSCLMRWWKNGSGKYFLKEEQDEI" gene complement(153504..154691) /gene="TIF2" /locus_tag="YJL138C" mRNA complement(153504..154691) /gene="TIF2" /locus_tag="YJL138C" /product="translation initiation factor eIF4A" CDS complement(153504..154691) /gene="TIF2" /locus_tag="YJL138C" /EC_number="3.6.4.13" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:1502180]" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:1502180]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:1502180]" /experiment="EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:24471916]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:1901195 positive regulation of formation of translation preinitiation complex [PMID:30281017|PMID:29192585]" /experiment="EXISTENCE:mutant phenotype:GO:0003724 RNA helicase activity [PMID:1502180]" /experiment="EXISTENCE:mutant phenotype:GO:0003743 translation initiation factor activity [PMID:1502180]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:1502180]" /experiment="EXISTENCE:mutant phenotype:GO:0016281 eukaryotic translation initiation factor 4F complex [PMID:2648398|PMID:10409745]" /note="Translation initiation factor eIF4A; DEAD-box RNA helicase that couples ATPase activity to mRNA binding and unwinding; ATP hydrolysis accelerates the recruitment of mRNA during 48S preinitiation complex (PIC) assembly; ATPase activity stimulated by either eIF4G1 or by the PIC in an eIF3g and eIFGi subunit-dependent manner, independent of eIF4E and eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E and eIF4G; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="translation initiation factor eIF4A" /protein_id="DAA08662.1" /db_xref="SGD:S000003674" /translation="MSEGITDIEESQIQTNYDKVVYKFDDMELDENLLRGVFGYGFEE PSAIQQRAIMPIIEGHDVLAQAQSGTGKTGTFSIAALQRIDTSVKAPQALMLAPTREL ALQIQKVVMALAFHMDIKVHACIGGTSFVEDAEGLRDAQIVVGTPGRVFDNIQRRRFR TDKIKMFILDEADEMLSSGFKEQIYQIFTLLPPTTQVVLLSATMPNDVLEVTTKFMRN PVRILVKKDELTLEGIKQFYVNVEEEEYKYECLTDLYDSISVTQAVIFCNTRRKVEEL TTKLRNDKFTVSAIYSDLPQQERDTIMKEFRSGSSRILISTDLLARGIDVQQVSLVIN YDLPANKENYIHRIGRGGRFGRKGVAINFVTNEDVGAMRELEKFYSTQIEELPSDIAT LLN" gene complement(154985..156127) /gene="GLG2" /locus_tag="YJL137C" mRNA complement(154985..156127) /gene="GLG2" /locus_tag="YJL137C" /product="glycogenin glucosyltransferase GLG2" CDS complement(154985..156127) /gene="GLG2" /locus_tag="YJL137C" /EC_number="2.4.1.186" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0005978 glycogen biosynthetic process [PMID:8524228]" /experiment="EXISTENCE:genetic interaction:GO:0008466 glycogenin glucosyltransferase activity [PMID:8524228]" /note="Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication" /codon_start=1 /product="glycogenin glucosyltransferase GLG2" /protein_id="DAA08663.1" /db_xref="SGD:S000003673" /translation="MAKKVAICTLLYSRDYLPGALTLAYQLQKLLKHAVVEDEITLCL LIEKKLFGDEFKPQEIALIRSLFKEIIIIEPLKDQEKSIEKNKANLELLKRPELSHTL LKARLWELVQFDQVLFLDADTLPLNKEFFEILRLYPEQTRFQIAAVPDIGWPDMFNTG VLLLIPDLDMATSLQDFLIKTVSIDGADQGIFNQFFNPICNYSKEVLHKVSPLMEWIR LPFTYNVTMPNYGYQSSPAMNFFQQHIRLIHFIGTFKPWSRNTTDYDDHYYQLWRSTQ RELYSECHLSNYFTHLQLGNIETETNFYHEPPCLQDLLNHGKRENQKHVDLDITSVDR NASQKSTAEKHDIEKPTSKPQSAFKFDWESTDYLDRVQRAFPKPDT" gene 156169..156252 /locus_tag="YJL136W-A" mRNA 156169..156252 /locus_tag="YJL136W-A" /product="hypothetical protein" CDS 156169..156252 /locus_tag="YJL136W-A" /note="hypothetical protein; identified by SAGE" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08664.1" /db_xref="SGD:S000028806" /translation="MTRCISKKMLLEVDALSLIYSPHLYMS" gene complement(156550..157273) /gene="RPS21B" /locus_tag="YJL136C" mRNA complement(join(156550..156789,157250..157273)) /gene="RPS21B" /locus_tag="YJL136C" /product="ribosomal 40S subunit protein S21B" CDS complement(join(156550..156789,157250..157273)) /gene="RPS21B" /locus_tag="YJL136C" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:3533916]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:3533916]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]" /experiment="EXISTENCE:mutant phenotype:GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication" /codon_start=1 /product="ribosomal 40S subunit protein S21B" /protein_id="DAA08665.1" /db_xref="SGD:S000003672" /translation="MENDKGQLVELYVPRKCSATNRIIKADDHASVQINVAKVDEEGR AIPGEYITYALSGYVRSRGESDDSLNRLAQNDGLLKNVWSYSR" gene 158188..159417 /gene="LCB3" /locus_tag="YJL134W" /gene_synonym="LBP1" /gene_synonym="YSR2" mRNA 158188..159417 /gene="LCB3" /locus_tag="YJL134W" /gene_synonym="LBP1" /gene_synonym="YSR2" /product="sphinganine kinase LCB3" CDS 158188..159417 /gene="LCB3" /locus_tag="YJL134W" /gene_synonym="LBP1" /gene_synonym="YSR2" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10477278|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0042392 sphingosine-1-phosphate phosphatase activity [PMID:9353337]" /experiment="EXISTENCE:mutant phenotype:GO:0019722 calcium-mediated signaling [PMID:11278643]" /note="Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication" /codon_start=1 /product="sphinganine kinase LCB3" /protein_id="DAA08666.1" /db_xref="SGD:S000003670" /translation="MVDGLNTSNIRKRARTLSNPNDFQEPNYLLDPGNHPSDHFRTRM SKFRFNIREKLLVFTNNQSFTLSRWQKKYRSAFNDLYFTYTSLMGSHTFYVLCLPMPV WFGYFETTKDMVYILGYSIYLSGFFKDYWCLPRPRAPPLHRITLSEYTTKEYGAPSSH TANATGVSLLFLYNIWRMQESSVMVQLLLSCVVLFYYMTLVFGRIYCGMHGILDLVSG GLIGIVCFIVRMYFKYRFPGLRIEEHWWFPLFSVGWGLLLLFKHVKPVDECPCFQDSV AFMGVVSGIECCDWLGKVFGVTLVYNLEPNCGWRLTLARLLVGLPCVVIWKYVISKPM IYTLLIKVFHLKDDRNVAARKRLEATHKEGASKYECPLYIGEPKIDILGRFIIYAGVP FTVVMCSPVLFSLLNIA" gene complement(159623..159847) /gene="DPI8" /locus_tag="YJL133C-A" mRNA complement(159623..159847) /gene="DPI8" /locus_tag="YJL133C-A" /product="Dpi8p" CDS complement(159623..159847) /gene="DPI8" /locus_tag="YJL133C-A" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /note="Putative mitochondrial hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /codon_start=1 /product="Dpi8p" /protein_id="DAA08667.1" /db_xref="SGD:S000028805" /translation="MIAQSTRLAAAVSSSAASAGVSRIAASAMASTIFKRSPGNSFNS FKEYRENAKTYGPLSASLATRRHLAHAPKL" gene 160619..161563 /gene="MRS3" /locus_tag="YJL133W" mRNA 160619..161563 /gene="MRS3" /locus_tag="YJL133W" /product="Fe(2+) transporter" CDS 160619..161563 /gene="MRS3" /locus_tag="YJL133W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:1703236]" /experiment="EXISTENCE:direct assay:GO:0048250 iron import into the mitochondrion [PMID:12902335]" /experiment="EXISTENCE:mutant phenotype:GO:0005381 iron ion transmembrane transporter activity [PMID:12902335]" /note="Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication" /codon_start=1 /product="Fe(2+) transporter" /protein_id="DAA08668.1" /db_xref="SGD:S000003669" /translation="MVENSSSNNSTRPIPAIPMDLPDYEALPTHAPLYHQLIAGAFAG IMEHSVMFPIDALKTRIQSANAKSLSAKNMLSQISHISTSEGTLALWKGVQSVILGAG PAHAVYFGTYEFCKKNLIDSSDTQTHHPFKTAISGACATTASDALMNPFDTIKQRIQL NTSASVWQTTKQIYQSEGLAAFYYSYPTTLVMNIPFAAFNFVIYESSTKFLNPSNEYN PLIHCLCGSISGSTCAAITTPLDCIKTVLQIRGSQTVSLEIMRKADTFSKAASAIYQV YGWKGFWRGWKPRIVANMPATAISWTAYECAKHFLMTY" gene 161914..164166 /locus_tag="YJL132W" mRNA 161914..164166 /locus_tag="YJL132W" /product="hypothetical protein" CDS 161914..164166 /locus_tag="YJL132W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:11935221]" /note="hypothetical protein; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08669.1" /db_xref="SGD:S000003668" /translation="MSIISSWLLVSIICLTTSIVTKLQAAGVTTHLFYLTRGAPLSLK ENYYPWLKAGSFFPDALYSCAPSNKDWSDFAEFTHWPNFLMIAVSYWQQKYGQNDRLR GTHGSLALKSFLIGVFTHQIVDVSWHSLVTDYRMHGLLRVLSETEFDGDIETAHTFLD VMGEFLTLNNVIRDSNNNENWDFLTRSDWKLPREEDLMEIIRNAGLSKEKLSYAELEF CVKRGMAAAISEGYLFRSQRNQLLTNIYSTSPRANDLILNHWLGGQSNLVAMLQRCVP FFETLFHDENTNEAQAEELRLCANLPPVSQKRINARPLVSSLKARKGNSHIVVSPMKS FSDFGTSLTMGKFREDNKDYLAVSAPLEDTVGAIYIVPWDILTVARKEDFSILQPITA MYGSKVGTYKASDVDYLLVSQPGTCTIDFYFKGVKILTIKDETTEEAHQLQFAVTGNF YDDKIPDLVVSSPSYGANETGIATFIPGSSIISYLTNSDKYQVVDISTFKGVINLDGY PMKIPFQHFGATIQISDTTDKQKLIYITCQSLGTVFVYSSNDLHDLSIPIYYITKNGV IPAKDSDHVEWHIIPSKEHGMFGAAIYSWNFEGMSFVAVSQPMFDTVFIYIEKSGQIE FFLKLVLKIKTKSDSIPDEFGSSLLFNDEEKKLYVSSPGSFDARGSIWKISMDELLKA GNDPKRKTLLINNLRHLMLINPDKSSKGVSNFGNSMILGPQNHLIVGIPQYGYGNFDH MQLTGRILVL" gene complement(164278..165348) /gene="AIM23" /locus_tag="YJL131C" /gene_synonym="MIF3" mRNA complement(164278..165348) /gene="AIM23" /locus_tag="YJL131C" /gene_synonym="MIF3" /product="Aim23p" CDS complement(164278..165348) /gene="AIM23" /locus_tag="YJL131C" /gene_synonym="MIF3" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0097177 mitochondrial ribosome binding [PMID:30927524]" /experiment="EXISTENCE:genetic interaction:GO:0070124 mitochondrial translational initiation [PMID:23954798]" /note="Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; interacts with mitochondrial ribosomal small subunit; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss" /codon_start=1 /product="Aim23p" /protein_id="DAA08670.1" /db_xref="SGD:S000003667" /translation="MLKVPLSDVLSQKMLFLKSFRYFHCTKYFSRDNASSTTDIFRNA MKRKRELANLKEQSHGNVARNAAFPKEYIKRPKQVPRNATNRKKILITWSTGTDRAKE AANSVVSEIFKKNHKGNIKVVDPTTHRIEASNIRYFAKGIDLDKVGLSIVNVEQIDNE NQIPLVKIVESRVALKKYSDFLAKKKEKELMELGVLNKSYKNLVTDKKEDNLKHIKIS WQIESDDLKRQKAHEIVSLLKKGNKVTLYLDDKNNINSNNWLENFEELDRSQKGEPPR LPESVFQKRAAVLETLKEIVSEYANDPVLLGNMNSKMIMKLIPKDVKPQNNDKRALKE LRKKERQEKLQKRIQRKKMNEM" gene complement(165723..172367) /gene="URA2" /locus_tag="YJL130C" mRNA complement(165723..172367) /gene="URA2" /locus_tag="YJL130C" /product="bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase" CDS complement(165723..172367) /gene="URA2" /locus_tag="YJL130C" /EC_number="2.1.3.2" /EC_number="6.3.5.5" /EC_number="3.5.1.2" /EC_number="6.3.4.16" /experiment="EXISTENCE:direct assay:GO:0004070 aspartate carbamoyltransferase activity [PMID:10446140]" /experiment="EXISTENCE:direct assay:GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [PMID:5776390]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11015727]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process [PMID:181668]" /experiment="EXISTENCE:direct assay:GO:0006541 glutamine metabolic process [PMID:5651325]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:11921093]" /experiment="EXISTENCE:direct assay:GO:0045984 negative regulation of pyrimidine nucleobase metabolic process [PMID:5651325]" /experiment="EXISTENCE:mutant phenotype:GO:0004070 aspartate carbamoyltransferase activity [PMID:4550660]" /experiment="EXISTENCE:mutant phenotype:GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process [PMID:4550660]" /note="Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP" /codon_start=1 /product="bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase" /protein_id="DAA08671.2" /db_xref="SGD:S000003666" /translation="MATIAPTAPITPPMESTGDRLVTLELKDGTVLQGYSFGAEKSVA GELVFQTGMVGYPESVTDPSYEGQILVITYPLVGNYGVPDMHLRDELVEELPRYFESN RIHIAGLVISHYTDEYSHYLAKSSLGKWLQNEGIPAVYGVDTRSLTKHLRDAGSMLGR LSLEKSGSDRTISRSSSWRSAFDVPEWVDPNVQNLVSKVSINEPKLYVPPADNKHIEL QTGPDGKVLRILAIDVGMKYNQIRCFIKRGVELKVVPWNYDFTKEDYDGLFISNGPGD PSVLDDLSQRLSNVLEAKKTPVFGICLGHQLIARAAGASTLKLKFGNRGHNIPCTSTI SGRCYITSQNHGFAVDVDTLTSGWKPLFVNANDDSNEGIYHSELPYFSVQFHPESTPG PRDTEFLFDVFIQAVKEFKYTQVLKPIAFPGGLLEDNVKAHPRIEAKKVLVLGSGGLS IGQAGEFDYSGSQAIKALKEEGIYTILINPNIATIQTSKGLADKVYFVPVTAEFVRKV ILHERPDAIYVTFGGQTALSVGIAMKDEFEALGVKVLGTPIDTIITTEDRELFSNAID EINEKCAKSQAANSVDEALAAVKEIGFPVIVRAAYALGGLGSGFANNEKELVDLCNVA FSSSPQVLVEKSMKGWKEVEYEVVRDAFDNCITVCNMENFDPLGIHTGDSIVVAPSQT LSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPVSKDYCIIEVNARLSRSSALASKA TGYPLAYTAAKLGLNIPLNEVKNSVTKSTCACFEPSLDYCVVKMPRWDLKKFTRVSTE LSSSMKSVGEVMSIGRTFEEAIQKAIRSTEYANLGFNETDLDIDIDYELNNPTDMRVF AIANAFAKKGYSVDKVWEMTRIDKWFLNKLHDLVQFAEKISSFGTKEELPSLVLRQAK QLGFDDRQIARFLDSNEVAIRRLRKEYGITPFVKQIDTVAAEFPAYTNYLYMTYNADS HDLSFDDHGVMVLGSGVYRIGSSVEFDWCAVTAVRTLRANNIKTIMVNYNPETVSTDY DEADRLYFETINLERVLDIYEIENSSGVVVSMGGQTSNNIAMTLHRENVKILGTSPDM IDSAENRYKFSRMLDQIGVDQPAWKELTSMDEAESFAEKVGYPVLVRPSYVLSGAAMN TVYSKNDLESYLNQAVEVSRDYPVVITKYIENAKEIEMDAVARNGELVMHVVSEHVEN AGVHSGDATLIVPPQDLAPETVDRIVVATAKIGKALKITGPYNIQFIAKDNEIKVIEC NVRASRSFPFISKVVGVNLIELATKAIMGLPLTPYPVEKLPDDYVAVKVPQFSFPRLA GADPVLGVEMASTGEVATFGHSKYEAYLKSLLATGFKLPKKNILLSIGSYKEKQELLS SVQKLYNMGYKLFATSGTADFLSEHGIAVQYLEVLNKDDDDQKSEYSLTQHLANNEID LYINLPSANRFRRPASYVSKGYKTRRLAVDYSVPLVTNVKCAKLLIEAISRNITLDVS ERDAQTSHRTITLPGLINIATYVPNASHVIKGPAELKETTRLFLESGFTYCQLMPRSI SGPVITDVASLKAANSVSQDSSYTDFSFTIAGTAHNAHSVTQSASKVTALFLPLRELK NKITAVAELLNQWPTEKQVIAEAKTADLASVLLLTSLQNRSIHITGVSNKEDLALIMT VKAKDPRVTCDVNIYSLFIAQDDYPEAVFLPTKEDQEFFWNNLDSIDAFSVGALPVAL ANVTGNKVDVGMGIKDSLPLLLAAVEEGKLTIDDIVLRLHDNPAKIFNIPTQDSVVEI DLDYSFRRNKRWSPFNKDMNGGIERVVYNGETLVLSGELVSPGAKGKCIVNPSPASIT ASAELQSTSAKRRFSITEEAIADNLDAAEDAIPEQPLEQKLMSSRPPRELVAPGAIQN LIRSNNPFRGRHILSIKQFKRSDFHVLFAVAQELRAAVAREGVLDLMKGHVITTIFFE PSTRTCSSFIAAMERLGGRIVNVNPLVSSVKKGETLQDTIRTLACYSDAIVMRHSEEM SVHIAAKYSPVPIINGGNGSREHPTQAFLDLFTIREEIGTVNGITVTFMGDLKHGRTV HSLCRLLMHYQVRINLVSPPELRLPEGLREELRKAGLLGVESIELTPHIISKTDVLYC TRVQEERFNSPEEYARLKDTYIVDNKILAHAKENMAIMHPLPRVNEIKEEVDYDHRAA YFRQMKYGLFVRMALLAMVMGVDM" gene complement(173599..177306) /gene="TRK1" /locus_tag="YJL129C" mRNA complement(173599..177306) /gene="TRK1" /locus_tag="YJL129C" /product="Trk1p" CDS complement(173599..177306) /gene="TRK1" /locus_tag="YJL129C" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16166647]" /experiment="EXISTENCE:direct assay:GO:0015079 potassium ion transmembrane transporter activity [PMID:3043197]" /experiment="EXISTENCE:direct assay:GO:0030007 intracellular potassium ion homeostasis [PMID:3043197]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:16166647]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006874 intracellular calcium ion homeostasis [PMID:33640956]" /note="Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication" /codon_start=1 /product="Trk1p" /protein_id="DAA08672.1" /db_xref="SGD:S000003665" /translation="MHFRRTMSRVPTLASLEIRYKKSFGHKFRDFIALCGHYFAPVKK YIFPSFIAVHYFYTISLTLITSILLYPIKNTRYIDTLFLAAGAVTQGGLNTVDINNLS LYQQIVLYIVCCISTPIAVHSCLAFVRLYWFERYFDGIRDSSRRNFKMRRTKTILERE LTARTMTKNRTGTQRTSYPRKQAKTDDFQEKLFSGEMVNRDEQDSVHSDQNSHDISRD SSNNNTNHNGSSGSLDDFVKEDETDDNGEYQENNSYSTVGSSSNTVADESLNQKPKPS SLRFDEPHSKQRPARVPSEKFAKRRGSRDISPADMYRSIMMLQGKHEATAEDEGPPLV IGSPADGTRYKSNVNKLKKATGINGNKIKIRDKGNESNTDQNSVSSEANSTASVSDES SLHTNFGNKVPSLRTNTHRSNSGPIAITDNAETDKKHGPSIQFDITKPPRKISKRVST FDDLNPKSSVLYRKKASKKYLMKHFPKARRIRQQIKRRLSTGSIEKNSSNNVSDRKPI TDMDDDDDDDDNDGDNNEEYFADNESGDEDERVQQSEPHSDSELKSHQQQQEKHQLQQ NLHRMYKTKSFDDNRSRAVPMERSRTIDMAEAKDLNELARTPDFQKMVYQNWKAHHRK KPNFRKRGWNNKIFEHGPYASDSDRNYPDNSNTGNSILHYAESILHHDGSHKNGSEEA SSDSNENIYSTNGGSDHNGLNNYPTYNDDEEGYYGLHFDTDYDLDPRHDLSKGSGKTY LSWQPTIGRNSNFLGLTRAQKDELGGVEYRAIKLLCTILVVYYVGWHIVAFVMLVPWI ILKKHYSEVVRDDGVSPTWWGFWTAMSAFNDLGLTLTPNSMMSFNKAVYPLIVMIWFI IIGNTGFPILLRCIIWIMFKISPDLSQMRESLGFLLDHPRRCFTLLFPKAATWWLLLT LAGLNITDWILFIILDFGSTVVKSLSKGYRVLVGLFQSVSTRTAGFSVVDLSQLHPSI QVSYMLMMYVSVLPLAISIRRTNVYEEQSLGLYGDMGGEPEDTDTEDDGNDEDDDEEN ESHEGQSSQRSSSNNNNNNNRKKKKKKKTENPNEISTKSFIGAHLRKQLSFDLWFLFL GLFIICICEGDKIKDVQEPNFNIFAILFEIVSAYGTVGLSLGYPDTNQSFSRQFTTLS KLVIIAMLIRGKNRGLPYSLDRAIILPSDRLEHIDHLEGMKLKRQARTNTEDPMTEHF KRSFTDVKHRWGALKRKTTHSRNPKRSSTTL" gene complement(178097..180103) /gene="PBS2" /locus_tag="YJL128C" /gene_synonym="HOG4" /gene_synonym="SFS4" /gene_synonym="SSK4" mRNA complement(178097..180103) /gene="PBS2" /locus_tag="YJL128C" /gene_synonym="HOG4" /gene_synonym="SFS4" /gene_synonym="SSK4" /product="mitogen-activated protein kinase kinase PBS2" CDS complement(178097..180103) /gene="PBS2" /locus_tag="YJL128C" /gene_synonym="HOG4" /gene_synonym="SFS4" /gene_synonym="SSK4" /EC_number="2.7.12.2" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9755161]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:10980703]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10980703]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:genetic interaction:GO:0038066 p38MAPK cascade [PMID:7624781]" /experiment="EXISTENCE:genetic interaction:GO:0071474 cellular hyperosmotic response [PMID:7624781]" /experiment="EXISTENCE:mutant phenotype:GO:0004708 MAP kinase kinase activity [PMID:7624781]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:15707964]" /experiment="EXISTENCE:mutant phenotype:GO:0006972 hyperosmotic response [PMID:7681220]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:7941729]" /experiment="EXISTENCE:mutant phenotype:GO:0007231 osmosensory signaling pathway [PMID:7624781]" /experiment="EXISTENCE:mutant phenotype:GO:0038066 p38MAPK cascade [PMID:15707964]" /experiment="EXISTENCE:physical interaction:GO:0005078 MAP-kinase scaffold activity [PMID:9180081|PMID:15200958|PMID:15200959]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:14685261]" /experiment="EXISTENCE:physical interaction:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:15200958]" /note="MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition" /codon_start=1 /product="mitogen-activated protein kinase kinase PBS2" /protein_id="DAA08673.2" /db_xref="SGD:S000003664" /translation="MEDKFANLSLHEKTGKSSIQLNEQTGSDNGSAVKRTSSTSSHYN NINADLHARVKAFQEQRALKRSASVGSNQSEQDKGSSQSPKHIQQIVNKPLPPLPVAG SSKVSQRMSSQVVQASSKSTLKNVLDNQETQNITDVNINIDTTKITATTIGVNTGLPA TDITPSVSNTASATHKAQLLNPNRRAPRRPLSTQHPTRPNVAPHKAPAIINTPKQSLS ARRGLKLPPGGMSLKMPTKTAQQPQQFAPSPSNKKHIETLSNSKVVEGKRSNPGSLIN GVQSTSTSSSTEGPHDTVGTTPRTGNSNNSSNSGSSGGGGLFANFSKYVDIKSGSLNF AGKLSLSSKGIDFSNGSSSRITLDELEFLDELGHGNYGNVSKVLHKPTNVIMATKEVR LELDEAKFRQILMELEVLHKCNSPYIVDFYGAFFIEGAVYMCMEYMDGGSLDKIYDES SEIGGIDEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVS GNLVASLAKTNIGCQSYMAPERIKSLNPDRATYTVQSDIWSLGLSILEMALGRYPYPP ETYDNIFSQLSAIVDGPPPRLPSDKFSSDAQDFVSLCLQKIPERRPTYAALTEHPWLV KYRNQDVHMSEYITERLERRNKILRERGENGLSKNVPALHMGGL" gene complement(181551..181709) /gene="MCO6" /locus_tag="YJL127C-B" /gene_synonym="YJL127C-A" mRNA complement(181551..181709) /gene="MCO6" /locus_tag="YJL127C-B" /gene_synonym="YJL127C-A" /product="Mco6p" CDS complement(181551..181709) /gene="MCO6" /locus_tag="YJL127C-B" /gene_synonym="YJL127C-A" /experiment="EXISTENCE:direct assay:GO:0001401 SAM complex [PMID:38377000]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:28658629]" /experiment="EXISTENCE:genetic interaction:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:38377000]" /experiment="EXISTENCE:mutant phenotype:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:38377000]" /note="Mitochondrial outer membrane protein protein; co-assembles with Mdm10p into the mitochondrial sorting and assembly machinery (SAM) complex and cooperates with Mdm10p in the assembly of the translocase of the outer membrane (TOM) complex; identified based on homology to the filamentous fungus, Ashbya gossypii; SWAT-GFP and seamless-GFP fusion proteins localize to the mitochondria" /codon_start=1 /product="Mco6p" /protein_id="DAA08674.1" /db_xref="SGD:S000028522" /translation="MIFFFNQIRSIFTALHTPTQQIQLSRRAFFQFLGYLGSCVVISL AAQSKYVQ" gene complement(182298..184220) /gene="SPT10" /locus_tag="YJL127C" /gene_synonym="CRE1" /gene_synonym="SUD1" mRNA complement(182298..184220) /gene="SPT10" /locus_tag="YJL127C" /gene_synonym="CRE1" /gene_synonym="SUD1" /product="Spt10p" CDS complement(182298..184220) /gene="SPT10" /locus_tag="YJL127C" /gene_synonym="CRE1" /gene_synonym="SUD1" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:16199888]" /experiment="EXISTENCE:direct assay:GO:1990841 promoter-specific chromatin binding [PMID:15882620]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:21057056]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17526727]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:21057056]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:17078097]" /experiment="EXISTENCE:mutant phenotype:GO:0010507 negative regulation of autophagy [PMID:26649943]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:21057056]" /note="Histone H3 acetylase with a role in transcriptional regulation; sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near TATA box; involved in S phase-specific acetylation of H3K56 at histone promoters, which is required for recruitment of SWI/SNF nucleosome remodeling complex and subsequent transcription" /codon_start=1 /product="Spt10p" /protein_id="DAA08675.1" /db_xref="SGD:S000003663" /translation="MLNQHTSSVPDDEHLQMAHQNSSSEVRNEAAVPDQLLTPLQPYT ILLKDGETIATMYPIPAYPDLLPLGLLNFLLDEFNMEVEKGDSFPYYETLSLEEFKNV WFHNDGHVCIMVLGEIPELDYSMDTEADTNDNFGTEIETTKHTTQYKKRKERRNLNLS MQWEKQCLGIFDLKPAYPGRSAHVVTGTFLVNAGIRGKGIGKTLMETFIEWSKKLGFT SSFFPLIYGTNVGIRRILEGLNFRRIGKLPEAGILKGFDVPVDSFMYGKEFTHITKSI DLLRDPQKSIEIGKYERLKHFLETGKYPLHCDRNEKARLRVLSKTHSVLNGKLMTKGK EIIYDTDQQIQIALEIHLMEHLGINKVTSKIGEKYHWRGIKSTVSEVISRCQKCKMRY KDGTGVIIEQKRAVKQAHMLPTQHIETINNPRKSKKHDNALLGQAINFPQNIISSTLN DVEGEPTPPDTNIVQPTFQNATNSPATTAEANEANKRSEFLSSIQSTPLLDDEQSMNS FNRFVEEENSRKRRKYLDVASNGIVPHLTNNESQDHANPVNRDERDMNHSVPDLDRND HTIMNDAMLSLEDNVMAALEMVQKEQQQKINHRGEDVTGQQIDLNNSEGNENSVTKIV NNESNTFTEHNSNIYY" gene 184501..185424 /gene="NIT2" /locus_tag="YJL126W" mRNA 184501..185424 /gene="NIT2" /locus_tag="YJL126W" /product="putative hydrolase" CDS 184501..185424 /gene="NIT2" /locus_tag="YJL126W" /EC_number="3.5.1.128" /experiment="EXISTENCE:direct assay:GO:0043605 amide catabolic process [PMID:28373563]" /experiment="EXISTENCE:direct assay:GO:0110050 deaminated glutathione amidase activity [PMID:28373563]" /note="Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member" /codon_start=1 /product="putative hydrolase" /protein_id="DAA08676.1" /db_xref="SGD:S000003662" /translation="MTSKLKRVAVAQLCSSADLTKNLKVVKELISEAIQKKADVVFLP EASDYLSQNPLHSRYLAQKSPKFIRQLQSSITDLVRDNSRNIDVSIGVHLPPSEQDLL EGNDRVRNVLLYIDHEGKILQEYQKLHLFDVDVPNGPILKESKSVQPGKAIPDIIESP LGKLGSAICYDIRFPEFSLKLRSMGAEILCFPSAFTIKTGEAHWELLGRARAVDTQCY VLMPGQVGMHDLSDPEWEKQSHMSALEKSSRRESWGHSMVIDPWGKIIAHADPSTVGP QLILADLDRELLQEIRNKMPLWNQRRDDLFH" gene complement(185528..186679) /gene="GCD14" /locus_tag="YJL125C" /gene_synonym="TRM61" mRNA complement(185528..186679) /gene="GCD14" /locus_tag="YJL125C" /gene_synonym="TRM61" /product="tRNA 1-methyladenosine methyltransferase subunit GCD14" CDS complement(185528..186679) /gene="GCD14" /locus_tag="YJL125C" /gene_synonym="TRM61" /EC_number="2.1.1.220" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9851972]" /experiment="EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:10779558]" /experiment="EXISTENCE:direct assay:GO:0031515 tRNA (m1A) methyltransferase complex [PMID:10779558]" /experiment="EXISTENCE:direct assay:GO:0160107 tRNA (adenine(58)-N1)-methyltransferase activity [PMID:10779558]" /experiment="EXISTENCE:mutant phenotype:GO:0160107 tRNA (adenine(58)-N1)-methyltransferase activity [PMID:10779558]" /experiment="EXISTENCE:physical interaction:GO:0031515 tRNA (m1A) methyltransferase complex [PMID:10779558]" /note="Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression" /codon_start=1 /product="tRNA 1-methyladenosine methyltransferase subunit GCD14" /protein_id="DAA08677.1" /db_xref="SGD:S000003661" /translation="MSTNCFSGYKDLIKEGDLTLIWVSRDNIKPVRMHSEEVFNTRYG SFPHKDIIGKPYGSQIAIRTKGSNKFAFVHVLQPTPELWTLSLPHRTQIVYTPDSSYI MQRLNCSPHSRVIEAGTGSGSFSHAFARSVGHLFSFEFHHIRYEQALEEFKEHGLIDD NVTITHRDVCQGGFLIKKGDTTSYEFGNNETAASLNANVVFLDLPAPWDAIPHLDSVI SVDEKVGLCCFSPCIEQVDKTLDVLEKYGWTDVEMVEIQGRQYESRRQMVRSLNDALE RLRDIKRHKLQGVERRKRMFNNTIDSNDEKVGKRNEDGVPLTEKAKFNPFGKGSRIKE GDSNYKWKEVTKMEAEIKSHTSYLTFAFKVVNRSRDDEKVNEILRSTEK" gene complement(187126..187644) /gene="LSM1" /locus_tag="YJL124C" /gene_synonym="SPB8" mRNA complement(187126..187644) /gene="LSM1" /locus_tag="YJL124C" /gene_synonym="SPB8" /product="Lsm1p" CDS complement(187126..187644) /gene="LSM1" /locus_tag="YJL124C" /gene_synonym="SPB8" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:18611963|PMID:12730603]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:23706738]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23706738]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18029398|PMID:23706738|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:1990726 Lsm1-7-Pat1 complex [PMID:24139796]" /experiment="EXISTENCE:mutant phenotype:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:10747033]" /experiment="EXISTENCE:mutant phenotype:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:10761922]" /experiment="EXISTENCE:mutant phenotype:GO:0000932 P-body [PMID:12730603]" /note="Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; also enters the nucleus and positively regulates transcription initiation; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; binds to mRNAs under glucose starvation, most often in the 3' UTR; forms cytoplasmic foci upon DNA replication stress" /codon_start=1 /product="Lsm1p" /protein_id="DAA08678.1" /db_xref="SGD:S000003660" /translation="MSANSKDRNQSNQDAKRQQQNFPKKISEGEADLYLDQYNFTTTA AIVSSVDRKIFVLLRDGRMLFGVLRTFDQYANLILQDCVERIYFSEENKYAEEDRGIF MIRGENVVMLGEVDIDKEDQPLEAMERIPFKEAWLTKQKNDEKRFKEETHKGKKMARH GIVYDFHKSDMY" gene complement(188004..189440) /gene="MTC1" /locus_tag="YJL123C" mRNA complement(188004..189440) /gene="MTC1" /locus_tag="YJL123C" /product="Mtc1p" CDS complement(188004..189440) /gene="MTC1" /locus_tag="YJL123C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:31323700]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]" /note="hypothetical protein that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1" /codon_start=1 /product="DUF5427 domain-containing protein MTC1" /protein_id="DAA08679.1" /db_xref="SGD:S000003659" /translation="MSENKNSEAEDVFEFLDSLPEAKNGGKMVNTDVKGSQEGVKGGS NSVAGKTGNDGKKGDDDIFEFLEELEKSNLSLTDKKGVEKKAPSESVNNKAQDEKVEE SKENKNSEQDAHGKEKEPQQQEKEEEEEEEEEEEEEEEETPLHDPIASISNWWSSSGS AKVSSIWNKTAEQASQIKNRLAQEQLDLTSKINTSTITEIARNLQKIVVGETEEVLRI HLVHDLVNYPSLQYNIESKFDQVLSSQVEGGIRIFVDEWGHPNNNGITPVEKKPSVAD GELGNSKKKLQFNLFDGKVTDGEKLAFANLENAVKLFNTAHEEYQKQQKEADATPDDD RSSISSNSNKISDLFISILPIAIPQKQKDADGDFQVTDSNTPGNFNFTLVLKDITNDI TTITRSQGFPVKWVNWLEGSVEKTGSTASEERNKSYDQKKQKESEDEDEDDEIIDPSE WVKEWIEDGLSLSFGVMAQNYVIDRMGL" gene 189716..190243 /gene="ALB1" /locus_tag="YJL122W" mRNA 189716..190243 /gene="ALB1" /locus_tag="YJL122W" /product="Alb1p" CDS 189716..190243 /gene="ALB1" /locus_tag="YJL122W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:16651379]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16651379]" /experiment="EXISTENCE:genetic interaction:GO:0042273 ribosomal large subunit biogenesis [PMID:16651379]" /experiment="EXISTENCE:physical interaction:GO:0042273 ribosomal large subunit biogenesis [PMID:16651379]" /note="Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p" /codon_start=1 /product="Alb1p" /protein_id="DAA08680.1" /db_xref="SGD:S000003658" /translation="MPSKNSINRPKLTSNLHHKVHSLNKKRAQRERAGLLKPARSSVN SKSGEIKSVALDLYFQNKKNESQNSTAVTLQNASSSPASITTRTLSKKRAKKIERNLK YATQRKLLVDASAKLEDEMDIDLDGGKKVKENEKKSSLTLVKEALWSVIDDTASQGLI IENGQGTTLGGPFFP" gene complement(190374..191090) /gene="RPE1" /locus_tag="YJL121C" /gene_synonym="EPI1" /gene_synonym="POS18" mRNA complement(190374..191090) /gene="RPE1" /locus_tag="YJL121C" /gene_synonym="EPI1" /gene_synonym="POS18" /product="ribulose-phosphate 3-epimerase RPE1" CDS complement(190374..191090) /gene="RPE1" /locus_tag="YJL121C" /gene_synonym="EPI1" /gene_synonym="POS18" /EC_number="5.1.3.1" /experiment="EXISTENCE:direct assay:GO:0004750 D-ribulose-phosphate 3-epimerase activity [PMID:8929392]" /experiment="EXISTENCE:mutant phenotype:GO:0004750 D-ribulose-phosphate 3-epimerase activity [PMID:8929392]" /experiment="EXISTENCE:mutant phenotype:GO:0006098 pentose-phosphate shunt [PMID:8929392]" /note="D-ribulose-5-phosphate 3-epimerase; catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress" /codon_start=1 /product="ribulose-phosphate 3-epimerase RPE1" /protein_id="DAA08681.1" /db_xref="SGD:S000003657" /translation="MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVP NITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFT FHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQ KFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHD VISFMKEEVSKELRSRDLLD" gene 191639..192298 /locus_tag="YJL118W" mRNA 191639..192298 /locus_tag="YJL118W" /product="hypothetical protein" CDS 191639..192298 /locus_tag="YJL118W" /note="hypothetical protein; may interact with ribosomes, based on co-purification experiments; YJL118W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08682.1" /db_xref="SGD:S000003654" /translation="MASCFSVSLLARVAVVEPIRVQLWLNVVNCMIESSMHQCPPRDR HFFSSSRPILLIRRSVSTVYRFVASRTTQVLRAAKTVVKWFIIVDPLINSILINYLID RLCTLGHAVLRVKKRKTEERQPCSPIIQHTHVKRRKRPRLRIVAIKRKRRRRRPHRIE RPLSNMYPIMEIQMVAVPLALPSPTALVHYQQQQQQLPQHHPWYDLSLSEEALSTCCC S" gene 192531..193466 /gene="PHO86" /locus_tag="YJL117W" mRNA 192531..193466 /gene="PHO86" /locus_tag="YJL117W" /product="Pho86p" CDS 192531..193466 /gene="PHO86" /locus_tag="YJL117W" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10655492|PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:15623581]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10655492]" /experiment="EXISTENCE:mutant phenotype:GO:0010966 regulation of phosphate transport [PMID:10655492]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:15623581]" /note="Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="Pho86p" /protein_id="DAA08683.1" /db_xref="SGD:S000003653" /translation="MAVQQRKKKEGRKSDKNAPSVPQVDASLDKPLDIDAPPTIYSVN LKPEYGTAALNLSADFIRQEQALANKYLFFHPVILVVLTIGLLIYLTPRIVFPIRNTG SVAGWFYQLARINKKVVLSGLVFTAIGASFLFTLLSRVSDSYFKSKINQLVGSKGEKV FGINLNDLVARHETKDPVVNNTHIIVYRETPIALISLAPNMTLSTDENLVMSVTTVGC RRVYVKSGIIEDLIDWAMLHSKNIRSSGKYGETMKLLIDVYSFDSTLKEILKKKGFTY IQSIRVSENRLLGGLFGVKKELWGLQFHFKAEHKD" gene complement(193860..194873) /gene="NCA3" /locus_tag="YJL116C" mRNA complement(193860..194873) /gene="NCA3" /locus_tag="YJL116C" /product="SUN family protein NCA3" CDS complement(193860..194873) /gene="NCA3" /locus_tag="YJL116C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0042776 proton motive force-driven mitochondrial ATP synthesis [PMID:7586026]" /note="Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the vacuole; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication" /codon_start=1 /product="SUN family protein NCA3" /protein_id="DAA08684.1" /db_xref="SGD:S000003652" /translation="MKISAALILSSLSSVAFSAPAPAPADSHHEDHHKDEKPAVVTVT QYIDSNAATSTVESAATTTTLSSSEKDTSEQKRDGGFQDGTVKCSDFPSVNGIVSLDW LGFGGWASVMDMDANTSSECKDGYYCSYACEPGMSKTQWPSDQPSDGKSVGGLYCKNG YLYRTNTDTSDLCSTDETSAKAINKKSDSIALCRTDYPGSENMVIPTVVDGGDSQPIS VVDEDTYYQWQGKKTSAQYYINNAGVSAEDGCIWGTSGSDVGNWAPLVLGAGSTNGET YLSLIPNPNSNQAANFNVKIVASDGANVQGSCAYEDGSFTGDGSDGCTVSVLSGSAEF VFY" gene 196287..197126 /gene="ASF1" /locus_tag="YJL115W" /gene_synonym="CIA1" mRNA 196287..197126 /gene="ASF1" /locus_tag="YJL115W" /gene_synonym="CIA1" /product="nucleosome assembly factor ASF1" CDS 196287..197126 /gene="ASF1" /locus_tag="YJL115W" /gene_synonym="CIA1" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:11404324]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:16303565]" /experiment="EXISTENCE:direct assay:GO:0006335 DNA replication-dependent chromatin assembly [PMID:11412995]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:22308335]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:15840725]" /experiment="EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:15840725]" /experiment="EXISTENCE:mutant phenotype:GO:0001932 regulation of protein phosphorylation [PMID:27222517]" /experiment="EXISTENCE:mutant phenotype:GO:0006337 nucleosome disassembly [PMID:16678113]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19620280]" /experiment="EXISTENCE:mutant phenotype:GO:0010468 regulation of gene expression [PMID:26941319]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:19620280]" /experiment="EXISTENCE:mutant phenotype:GO:0042393 histone binding [PMID:15840725]" /note="Nucleosome assembly factor; involved in chromatin assembly, disassembly; required for recovery after DSB repair; role in H3K56 acetylation required for expression homeostasis, buffering mRNA synthesis rate against gene dosage changes in S phase; anti-silencing protein, derepresses silent loci when overexpressed; role in regulating Ty1 transposition; relocalizes to cytosol under hypoxia; growth defect of asf1 null is functionally complemented by either human ASF1A or ASF1B" /codon_start=1 /product="nucleosome assembly factor ASF1" /protein_id="DAA08685.1" /db_xref="SGD:S000003651" /translation="MSIVSLLGIKVLNNPAKFTDPYEFEITFECLESLKHDLEWKLTY VGSSRSLDHDQELDSILVGPVPVGVNKFVFSADPPSAELIPASELVSVTVILLSCSYD GREFVRVGYYVNNEYDEEELRENPPAKVQVDHIVRNILAEKPRVTRFNIVWDNENEGD LYPPEQPGVDDEEEEDDEEEDDDEDDEDDEDDDQEDGEGEAEEAAEEEEEEEEKTEDN ETNLEEEEEDIENSDGDEEEGEEEVGSVDKNEDGNDKKRRKIEGGSTDIESTPKDAAR STN" gene complement(197313..197385) /locus_tag="YNCJ0005C" tRNA complement(197313..197385) /locus_tag="YNCJ0005C" /product="tRNA-Ala" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Alanine tRNA (tRNA-Ala), predicted by tRNAscan-SE analysis; one of 11 nuclear tRNA genes containing the tDNA-anticodon AGC (converted to IGC in the mature tRNA), decodes GCU and GCC codons into alanine, one of 16 nuclear tRNAs for alanine" /db_xref="SGD:S000006514" repeat_region 197401..197494 /note="Ty3 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007035" mobile_element 197545..203768 /note="YJLWTy4-1; Ty4 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats" /mobile_element_type="retrotransposon:YJLWTy4-1" /db_xref="SGD:S000007039" repeat_region 197545..197915 /note="Ty4 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007036" gene 197915..198595 /locus_tag="YJL114W" mRNA 197915..198595 /locus_tag="YJL114W" /product="gag protein" CDS 197915..198595 /locus_tag="YJL114W" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /codon_start=1 /product="gag protein" /protein_id="DAA08687.2" /db_xref="SGD:S000003650" /translation="MATPVRGETRNVIDDNISARIQSKVKTNDTVRQTPSSLRKVSIK DEQVRQYQRNLNRFKTILNGLKAEEEKLSEADDIQMLAEKLLKLGETIDKVENRIVDL VEKIQLLETNENNNILHEHIDATGTYYLFDTLTSTNKRFYPKDCVFDYRTNNVENIPI LLNNFKKFIKKYQFDDVFENDIIEIDPRENEILCKIIKEGLGESLDIMNTNTTDIFRI IDGLKKQI" gene 198678..203325 /locus_tag="YJL113W" mRNA 198678..203325 /locus_tag="YJL113W" /product="gag-pol fusion protein" CDS join(198678..198998,199000..203325) /locus_tag="YJL113W" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /ribosomal_slippage /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /codon_start=1 /product="gag-pol fusion protein" /protein_id="DAA08686.2" /db_xref="SGD:S000003649" /translation="MNKLQKLVLMEKWIFSKCCQDCPNLKDYLQEAIMGTLHESLRNS VKQRLYNIPHDVGIDHEEFLINTVIETVIDLSPIADDQIENSCMYCKSVFHCSINCKK KPNRELGLTRPISQKPIIYKVHRDNNHLSPVQNEQKSWNKTQKRSNKVYNSKKLVIID TGSGVNITNDKTLLHNYEDSNRSTRFFGIGKNSSVSVKGYGYIKIKNGHNNTDNKCLL TYYVPEEESTIISCYDLAKKTKMVLSRKYTRLGNKIIKIKTKIVNGVIHVKMNELIER PSDDSKINAIKPTSSPGFKLNKRSITLEDAHKRMGHTGIQQIENSIKHNHYEESLDLI KEPNEFWCQTCKISKATKRNHYTGSMNNHSTDHEPGSSWCMDIFGPVSSSNADTKRYM LIMVDNNTRYCMTSTHFNKNAETILAQVRKNIQYVETQFDRKVREINSDRGTEFTNDQ IEEYFISKGIHHILTSTQDHAANGRAERYIRTIITDATTLLRQSNLRVKFWEYAVTSA TNIRNYLEHKSTGKLPLKAISRQPVTVRLMSFLPFGEKGIIWNHNHKKLKPSGLPSII LCKDPNSYGYKFFIPSKNKIVTSDNYTIPNYTMDGRVRNTQNINKSHQFSSDNDDEED QIETVTNLCEALENYEDDNKPITRLEDLFTEEELSQIDSNAKYPSPSNNLEGDLDYVF SDVEESGDYDVESELSTTNNSISTDKNKILSNKDFNSELASTEISISGIDKKGLINTS HIDEDKYDEKVHRIPSIIQEKLVGSKNTIKINDENKISDRIRSKNIGSILNTGLSRCV DITDESITNKDESMHNAKPELIQEQLKKTNHETSFPKEGSIGTNVKFRNTNNEISLKT GDTSLPIKTLESINNHHSNDYSTNKVEKFEKENHHPPPIEDIVDMSDQTDMESNCQDG NNLKELKVTDKNVPTDNGTNVSPRLEQNIEASGSPVQTVNKSAFLNKEFSSLNMKRKR KRHDKNNSLTSYELERDKKRSKKNRVKLIPDNMETVSAPKIRAIYYNEAISKNPDLKE KHEYKQAYHKELQNLKDMKVFDVDVKYSRSEIPDNLIVPTNTIFTKKRNGIYKARIVC RGDTQSPDTYSVITTESLNHNHIKIFLMIANNRNMFMKTLDINHAFLYAKLEEEIYIP HPHDRRCVVKLNKALYGLKQSPKEWNDHLRQYLNGIGLKDNSYTPGLYQTEDKNLMIA VYVDDCVIAASNEQRLDEFINKLKSNFELKITGTLIDDVLDTDILGMDLVYNKRLGTI DLTLKSFINRMDKKYNEELKKIRKSSIPHMSTYKIDPKKDVLQMSEEEFRQGVLKLQQ LLGELNYVRHKCRYDIEFAVKKVARLVNYPHERVFYMIYKIIQYLVRYKDIGIHYDRD CNKDKKVIAITDASVGSEYDAQSRIGVILWYGMNIFNVYSNKSTNRCVSSTEAELHAI YEGYADSETLKVTLKELGEGDNNDIVMITDSKPAIQGLNRSYQQPKEKFTWIKTEIIK EKIKEKSIKLLKITGKGNIADLLTKPVSASDFKRFIQVLKNKITSQDILASTDY" repeat_region 203398..203768 /note="Ty4 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007037" repeat_region complement(203783..204114) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007022" rep_origin 204029..204917 /note="ARS1008; Autonomously Replicating Sequence" /db_xref="SGD:S000028445" gene 204735..204806 /locus_tag="YNCJ0006W" tRNA 204735..204806 /locus_tag="YNCJ0006W" /product="tRNA-Asp" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Aspartate tRNA (tRNA-Asp), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006536" gene 205305..207449 /gene="MDV1" /locus_tag="YJL112W" /gene_synonym="GAG3" /gene_synonym="NET2" mRNA 205305..207449 /gene="MDV1" /locus_tag="YJL112W" /gene_synonym="GAG3" /gene_synonym="NET2" /product="Mdv1p" CDS 205305..207449 /gene="MDV1" /locus_tag="YJL112W" /gene_synonym="GAG3" /gene_synonym="NET2" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:11038182|PMID:11038180|PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]" /experiment="EXISTENCE:genetic interaction:GO:0000266 mitochondrial fission [PMID:11179417]" /experiment="EXISTENCE:genetic interaction:GO:0016559 peroxisome fission [PMID:18445678]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:11038182]" /experiment="EXISTENCE:mutant phenotype:GO:0000266 mitochondrial fission [PMID:11179417|PMID:11038183|PMID:11038182|PMID:11038180]" /experiment="EXISTENCE:physical interaction:GO:0000266 mitochondrial fission [PMID:11038182|PMID:11179417]" /note="Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the self-assembled oligomeric form of the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication" /codon_start=1 /product="Mdv1p" /protein_id="DAA08688.1" /db_xref="SGD:S000003648" /translation="MSVNDQITHIGKTLSTTASAFLNYQKSNSNTQDVLTNNGPYKNL LSNTVNNASSTSYFYKRTEHGRFVKNASNTFEDIYSKTRRGDVFRNKFTDNKTCFRML TYISDDLLNEIPTKEGLKSDADGKLLTEGGENENLRKNASKKETSLFQGFKSYLPIAE LAIENTERLNYDTNGTSGTVGAKDVMSKTNERDEIHTELPNFQDSFLIPPGVETKKIS SSYSPSALKSFSQTLVNSLEFLNIQKNSTLSEIRDIEVEVENLRQKKEKLLGKIANIE QNQLLLEDNLKQIDDRLDFLEEYGLEVIEANSDENAEDDGMSERKALKNDAIRNEGVT TESISSEASNLPPRRRQQLRDDNSLNRLGAFYSKSKKRHRKSFPTFQQLYEPGTKIGS IMSTHDDFLTCLDFDAPFGTLCTAGYLDHTVKIWDLSKQNKIGELAGHLATINCMQIN RDYGTLVTGGRDAALKLWNLNLAQQLYQETQNLTSPTNHIDSPCVHTFEAHTDEVTAL SLDPSFLVSGSQDRTIRQWDLRSGKCLQTIDLSFANVLTTSTNVDLSKSTLLTQRNER PSIGALQSFDAALATGTKDGVVRLWDLRSGKVIRTLKGHTDAITSLKFDSACLVTGSY DRTVRIWDLRTGLLNKFHAYSAPVLSLDLFQENAAVVVADEPSVQIYDSEKDESWSCV EQGNETSVSTVKYKENYMVEGRENGDVNIWAV" gene 207877..209529 /gene="CCT7" /locus_tag="YJL111W" /gene_synonym="TCP7" mRNA 207877..209529 /gene="CCT7" /locus_tag="YJL111W" /gene_synonym="TCP7" /product="chaperonin-containing T-complex subunit CCT7" CDS 207877..209529 /gene="CCT7" /locus_tag="YJL111W" /gene_synonym="TCP7" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005832 chaperonin-containing T-complex [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16762366]" /experiment="EXISTENCE:physical interaction:GO:0005832 chaperonin-containing T-complex [PMID:15704212]" /note="Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance" /codon_start=1 /product="chaperonin-containing T-complex subunit CCT7" /protein_id="DAA08689.1" /db_xref="SGD:S000003647" /translation="MNFGSQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTL GPLGSDILIVTSNQKTTISNDGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVT ILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLER CARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLDDKLIGIKKIPGGAMEESLFINGV AFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQ LIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSI QSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERS LHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIP RQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALN SATEATNLILSVDETITNKGSESANAGMMPPQGAGRGRGMPM" gene complement(209922..211577) /gene="GZF3" /locus_tag="YJL110C" /gene_synonym="DEH1" /gene_synonym="NIL2" mRNA complement(209922..211577) /gene="GZF3" /locus_tag="YJL110C" /gene_synonym="DEH1" /gene_synonym="NIL2" /product="Gzf3p" CDS complement(209922..211577) /gene="GZF3" /locus_tag="YJL110C" /gene_synonym="DEH1" /gene_synonym="NIL2" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:19380492]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19380492]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:9171383]" /experiment="EXISTENCE:genetic interaction:GO:0090295 nitrogen catabolite repression of transcription [PMID:9106207]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9171383]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:19380492]" /experiment="EXISTENCE:mutant phenotype:GO:0090295 nitrogen catabolite repression of transcription [PMID:9171383|PMID:9171427]" /experiment="EXISTENCE:physical interaction:GO:0051457 maintenance of protein location in nucleus [PMID:19380492]" /note="GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication" /codon_start=1 /product="Gzf3p" /protein_id="DAA08690.1" /db_xref="SGD:S000003646" /translation="MASQATTLRGYNIRKRDNVFEPKSSENLNSLNQSEEEGHIGRWP PLGYEAVSAEQKSAVQLRESQAGASISNNMNFKANDKSFSTSTAGRMSPDTNSLHHIL PKNQVKNNGQTMDANCNNNVSNDANVPVCKNCLTSTTPLWRRDEHGAMLCNACGLFLK LHGKPRPISLKTDVIKSRNRKSNTNHAHNLDNFRNQTLIAELKGDCNIESSGRKANRV TSEDKKKKSSQLLMGTSSTAKISKKPKTESKERSDSHLSATKLEVLMSGDCSRPNLKP KLPKQDTAIYQEKLLTFPSYTDVKEYSNSAHQSAFIKERSQFNAASFPLNASHSVTSK TGADSPQLPHLSMLLGSLSSTSISNNGSEIVSNCNNGIASTAATLAPTSSRTTDSNPS EVPNQIRSTMSSPDIISAKRNDPAPLSFHMASINDMLETRDRAISNVKTETTPPHFIP FLQSSKAPCISKANSQSISNSVSSSDVSGRKFENHPAKDLGDQLSTKLHKEEEIIKLK TRINELELVTDLYRRHINELDGKCRALEERLQRTVKQEGNKGG" gene complement(212000..217309) /gene="UTP10" /locus_tag="YJL109C" mRNA complement(212000..217309) /gene="UTP10" /locus_tag="YJL109C" /product="snoRNA-binding rRNA-processing protein UTP10" CDS complement(212000..217309) /gene="UTP10" /locus_tag="YJL109C" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22842922|PMID:12150911|PMID:12068309|PMID:17652137]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:17652137|PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:17652137]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:15489292]" /experiment="EXISTENCE:direct assay:GO:0034455 t-UTP complex [PMID:17515605]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17652137]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17652137]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17652137]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:15489292]" /note="Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance" /codon_start=1 /product="snoRNA-binding rRNA-processing protein UTP10" /protein_id="DAA08691.1" /db_xref="SGD:S000003645" /translation="MSSLSDQLAQVASNNATVALDRKRRQKLHSASLIYNSKTAATQD YDFIFENASKALEELSQIEPKFAIFSRTLFSESSISLDRNVQTKEEIKDLDNAINAYL LLASSKWYLAPTLHATEWLVRRFQIHVKNTEMLLLSTLNYYQTPVFKRILSIIKLPPL FNCLSNFVRSEKPPTALTMIKLFNDMDFLKLYTSYLDQCIKHNATYTNQLLFTTCCFI NVVAFNSNNDEKLNQLVPILLEISAKLLASKSKDCQIAAHTILVVFATALPLKKTIIL AAMETILSNLDAKEAKHSALLTICKLFQTLKGQGNVDQLPSKIFKLFDSKFDTVSILT FLDKEDKPVCDKFITSYTRSIARYDRSKLNIILSLLKKIRLERYEVRLIITDLIYLSE ILEDKSQLVELFEYFISINEDLVLKCLKSLGLTGELFEIRLTTSLFTNADVNTDIVKQ LSDPVETTKKDTASFQTFLDKHSELINTTNVSMLTETGERYKKVLSLFTEAIGKGYKA SSFLTSFFTTLESRITFLLRVTISPAAPTALKLISLNNIAKYINSIEKEVNIFTLVPC LICALRDASIKVRTGVKKILSLIAKRPSTKHYFLSDKLYGENVTIPMLNPKDSEAWLS GFLNEYVTENYDISRILTPKRNEKVFLMFWANQALLIPSPYAKTVLLDNLNKSPTYAS SYSSLFEEFISHYLENRSSWEKSCIANKTNFEHFERSLVNLVSPKEKQSFMIDFVLSA LNSDYEQLANIAAERLISIFASLNNAQKLKIVQNIVDSSSNVESSYDTVGVLQSLPLD SDIFVSILNQNSISNEMDQTDFSKRRRRRSSTSKNAFLKEEVSQLAELHLRKLTIILE ALDKVRNVGSEKLLFTLLSLLSDLETLDQDGGLPVLYAQETLISCTLNTITYLKEHGC TELTNVRADILVSAIRNSASPQVQNKLLLVIGSLATLSSEVILHSVMPIFTFMGAHSI RQDDEFTTKVVERTILTVVPALIKNSKGNEKEEMEFLLLSFTTALQHVPRHRRVKLFS TLIKTLDPVKALGSFLFLIAQQYSSALVNFKIGEARILIEFIKALLVDLHVNEELSGL NDLLDIIKLLTSSKSSSEKKKSLESRVLFSNGVLNFSESEFLTFMNNTFEFINKITEE TDQDYYDVRRNLRLKVYSVLLDETSDKKLIRNIREEFGTLLEGVLFFINSVELTFSCI TSQENEEASDSETSLSDHTTEIKEILFKVLGNVLQILPVDEFVNAVLPLLSTSTNEDI RYHLTLVIGSKFELEGSEAIPIVNNVMKVLLDRMPLESKSVVISQVILNTMTALVSKY GKKLEGSILTQALTLATEKVSSDMTEVKISSLALITNCVQVLGVKSIAFYPKIVPPSI KLFDASLADSSNPLKEQLQVAILLLFAGLIKRIPSFLMSNILDVLHVIYFSREVDSSI RLSVISLIIENIDLKEVLKVLFRIWSTEIATSNDTVAVSLFLSTLESTVENIDKKSAT SQSPIFFKLLLSLFEFRSISSFDNNTISRIEASVHEISNSYVLKMNDKVFRPLFVILV RWAFDGEGVTNAGITETERLLAFFKFFNKLQENLRGIITSYFTYLLEPVDMLLKRFIS KDMENVNLRRLVINSLTSSLKFDRDEYWKSTSRFELISVSLVNQLSNIENSIGKYLVK AIGALASNNSGVDEHNQILNKLIVEHMKASCSSNEKLWAIRAMKLIYSKIGESWLVLL PQLVPVIAELLEDDDEEIEREVRTGLVKVVENVLGEPFDRYLD" gene complement(217705..218856) /gene="PRM10" /locus_tag="YJL108C" mRNA complement(217705..218856) /gene="PRM10" /locus_tag="YJL108C" /product="pheromone-regulated protein PRM10" CDS complement(217705..218856) /gene="PRM10" /locus_tag="YJL108C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Pheromone-regulated protein; proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation" /codon_start=1 /product="pheromone-regulated protein PRM10" /protein_id="DAA08692.1" /db_xref="SGD:S000003644" /translation="MIVSFGDATTRTSEVQLVRCTQGLNLWKLHQVHAVYKRVVHDTL GADEGNALLDQILADTNLYPPWMCVLLYAFCSAMVTPYAFGGDWVNLAISFFMGLCVG SLQFILSQKSYMYSNVFEISASIVVSFCGRAFGSIPRSHICFGAVTQGSLALILPGYI ILCGALELQSRSLVAGAVRMFYAIIYSLFLGFGITLGSALFGWMYHNATNEISCPQLI SPWFRFLFVPAFTISISLLNQAHISQLPVMVFISCTGYVVTYWAGKHFANSTEFTAAL AAFVIGVLGNLYSRIWKGLAVSAMLPAIFVQVPSGIASQNSLLSGLQSANTIVNANET ITTSTSDPSSSMSFGMTMIQVCVGISVGLFASSLFVYPFGKKKTGLFSL" gene complement(218853..220016) /locus_tag="YJL107C" mRNA complement(218853..220016) /locus_tag="YJL107C" /product="hypothetical protein" CDS complement(218853..220016) /locus_tag="YJL107C" /note="hypothetical protein; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08693.1" /db_xref="SGD:S000003643" /translation="MDGRNEKPTTPVSDFRVGSSEQSQAGVNLEDSSDHRTSNSAESK KGNLSGKSISDLGISNNDNKNVRFTADTDALENDLSSRSTETSDNSKGTDGQDEEDRP ARHKRKPKVSFTHLRNNGKDGDDETFIKKIINNLTGNQGGLVPGLAPIPSENENGKND IEKNNRNEEIPLSDLADASKIVDVHEGDDKEKLEALKLEGDVNCTSDGETLGSSSKNS FLAPAVDHFDDYAENNSSDDNEGFIETSTYVPPPSQVKSGVLGSLLKLYQNEDQNSSS IFSDSQAVTTDDEGISSTAGNKDVPVAKRSRLQNLKGKAKKGRMPRLKKRLKTEAKIT VHIADILQRHRFILRMCRALMMYGAPTHRLEEYMVMTSRVLEIDGQFCIFQVV" gene 221390..223327 /gene="IME2" /locus_tag="YJL106W" /gene_synonym="SME1" mRNA 221390..223327 /gene="IME2" /locus_tag="YJL106W" /gene_synonym="SME1" /product="protein kinase IME2" CDS 221390..223327 /gene="IME2" /locus_tag="YJL106W" /gene_synonym="SME1" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:7764269|PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7764269]" /experiment="EXISTENCE:genetic interaction:GO:1902596 negative regulation of DNA replication origin binding [PMID:29388912]" /experiment="EXISTENCE:mutant phenotype:GO:0040020 regulation of meiotic nuclear division [PMID:9003314]" /experiment="EXISTENCE:mutant phenotype:GO:1902596 negative regulation of DNA replication origin binding [PMID:29388912]" /note="Serine/threonine protein kinase involved in activation of meiosis; associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p; human CDK2 can complement ime2 null mutant" /codon_start=1 /product="protein kinase IME2" /protein_id="DAA08694.1" /db_xref="SGD:S000003642" /translation="MVEKRSRQSSSSGSEFSVPPDVDNPPLSIPLKTLSDRYQLIEKL GAGSFGCVTLAKAQFPLSNILGKQHDIRGTLMDQPKNGHQNYITKTQGVVAIKTMMTK LHTLQDYTRVREIKFILAIPANDHLIQIFEVFIDSENYQLHIVMECMEQNLYQMMKHR RRRVFSIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQIGY QDNYVIKLADFGLARHVENKNPYTAYVSTRWYRSPEILLRSGYYSKPLDIWAFGCVAV EVTVFRALFPGANEIDQIWKILEVLGTPIKRSDFVNTNHITAPPPGGFWDDASNLVHK LNLKLPYVEGSSLDHLLSSSQLSDLSEVVKKCLRWDPNERATAQELCEMPFFENTVAS QVDARGNVTNTEQALIFAGINPVATNTKPIYFNSSTKLPAETESNDIDISNNDHDSHA MCSPTLNQEKLTLVEFLNEFVEEDNDDHSIPDVGTDSTISDSIDETELSKEIRNNLAL CQLPDEEVLDHSLSNIRQLTNDIEIINKDEADNMEQLFFDLEIPEKDEFQRKQPFNEH ADIDEDIVLPYVNNSNYTHTDRSHHRGDNVLGDASLGDSFNSMPDFTPRNFLIPTLKK SREKFEPHLSNSNQHFGNVTF" gene 225055..226737 /gene="SET4" /locus_tag="YJL105W" mRNA 225055..226737 /gene="SET4" /locus_tag="YJL105W" /product="Set4p" CDS 225055..226737 /gene="SET4" /locus_tag="YJL105W" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:34625508]" /experiment="EXISTENCE:mutant phenotype:GO:1900407 regulation of cellular response to oxidative stress [PMID:30082318]" /note="Chromatin-associated protein involved in control of stress response; regulates response to oxidative stress; involved in control of gene repression in subtelomeric chromatin; contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication" /codon_start=1 /product="Set4p" /protein_id="DAA08695.1" /db_xref="SGD:S000003641" /translation="MTSPESLSSRHIRQGRTYTTTDKVISRSSSYSSNSSMSKDYGDH TPLSVSSAASETLPSPQYMPIRTFNTMPTAGPTPLHLFQNDRGIFNHHSSSGSSKTAS TNKRGIAAAVALATAATIPFPLKKQNQDDNSKVSVTHNESSKENKITPSMRAEDNKPK NGCICGSSDSKDELFIQCNKCKTWQHKLCYAFKKSDPIKRDFVCKRCDSDTKVQVNQV KPMIFPRKMGDERLFQFSSIVTTSASNTNQHQQSVNNIEEQPKKRQLHYTAPTTENSN SIRKKLRQEKLVVSSHFLKPLLNEVSSSNDTEFKAITISEYKDKYVKMFIDNHYDDDW VVCSNWESSRSADIEVRKSSNERDFGVFAADSCVKGELIQEYLGKIDFQKNYQTDPNN DYRLMGTTKPKVLFHPHWPLYIDSRETGGLTRYIRRSCEPNVELVTVRPLDEKPRGDN DCRVKFVLRAIRDIRKGEEISVEWQWDLRNPIWEIINASKDLDSLPDPDKFWLMGSIK TILTNCDCACGYLGHNCPITKIKNFSEEFMRNTKESLSNKSYFNTIMHNCKP" gene 227327..227776 /gene="PAM16" /locus_tag="YJL104W" /gene_synonym="MIA1" /gene_synonym="TIM16" mRNA 227327..227776 /gene="PAM16" /locus_tag="YJL104W" /gene_synonym="MIA1" /gene_synonym="TIM16" /product="import motor complex subunit PAM16" CDS 227327..227776 /gene="PAM16" /locus_tag="YJL104W" /gene_synonym="MIA1" /gene_synonym="TIM16" /experiment="EXISTENCE:direct assay:GO:0001405 PAM complex, Tim23 associated import motor [PMID:14981507|PMID:14981506]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005744 TIM23 mitochondrial import inner membrane translocase complex [PMID:14981506]" /experiment="EXISTENCE:direct assay:GO:0019904 protein domain specific binding [PMID:16105940]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:14981506|PMID:14981507]" /note="Subunit of the import motor (PAM complex); the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain" /codon_start=1 /product="import motor complex subunit PAM16" /protein_id="DAA08696.1" /db_xref="SGD:S000003640" /translation="MAHRAFIQVIITGTQVFGKAFAEAYRQAASQSVKQGATNASRRG TGKGEYGGITLDESCKILNIEESKGDLNMDKINNRFNYLFEVNDKEKGGSFYLQSKVY RAAERLKWELAQREKNAKAKAGDASTAKPPPNSTNSSGADNSASSNQ" gene complement(228094..228479) /gene="SNR37" /locus_tag="YNCJ0007C" ncRNA complement(228094..228479) /ncRNA_class="snoRNA" /gene="SNR37" /locus_tag="YNCJ0007C" /product="SNR37" /experiment="EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:9160748]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:35385737]" /experiment="EXISTENCE:mutant phenotype:GO:0030559 rRNA pseudouridylation guide activity [PMID:35385737|PMID:9160748]" /experiment="EXISTENCE:mutant phenotype:GO:0031118 rRNA pseudouridine synthesis [PMID:9160748]" /experiment="EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:35385737]" /experiment="EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:15923376|PMID:9472021]" /note="H/ACA box small nucleolar RNA (snoRNA) involved in ribosome synthesis; has structural role in early pre-60S pathway; guides pseudouridylation of large subunit (LSU) rRNA at position U2944" /db_xref="SGD:S000006501" rep_origin 228552..229043 /note="ARS1009; Autonomously Replicating Sequence" /db_xref="SGD:S000028446" gene complement(229025..230881) /gene="GSM1" /locus_tag="YJL103C" mRNA complement(229025..230881) /gene="GSM1" /locus_tag="YJL103C" /product="Gsm1p" CDS complement(229025..230881) /gene="GSM1" /locus_tag="YJL103C" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:16785442]" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:16785442]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:16785442]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:16785442]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:16785442]" /note="Putative zinc cluster hypothetical protein; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis" /codon_start=1 /product="Gsm1p" /protein_id="DAA08697.1" /db_xref="SGD:S000003639" /translation="MTKKLPSELKQTRKSIQTACEFCHTKHIQCDVGRPCQNCLKRNI GKFCRDKKRKSRKRIEKHGTQPYLNLGKRLVIHDVPSKTVSPSSVHLQRDFLSSDQEK PGKTPAHNTNIQYTYNINDNFQSAGSIPRITNFNTNNRQTVLENTSNNISASQAVHLM NDPIIPTVRKSTLNLKSHFLEQHKAMQQPLATNCLVATSNVPVHSGMDDSNKSDDDVD DETNIHFDSMWCNDEYMKLKDIVDISTPFLPNNSQIFSLQESEYPNPSASTRGNSSLH LTNLLNSTKSVNDQKDSSIGHSTSTFNTYDEVVSRPFISLDMLHLNRGANANTHPSHN AKLESECDSSSHSDADLEKHDTDFISPSKFRELVKTPQDLYDNKCLIKPHNYKLAYTK LLTTLRKKFLEGAEIDKSASVKDEHSTQKHNLRYDLEVIIRSILERYAPIFISLTSNM IEEDLLLQEVTLQRALLDLENMAKLVSCTPMCIWRRSGEICFVSNEFYSLTGFNKNLL LDRTSFIFEYLDHKSVSNYFQIFNELLAFGYNDINKRKKLLMLNACSSTSSKITEGFS FTTDGKAIFTKCNLLLSNGLYLKCACCWTVKRDSFNIPILVMGQFLPIFEMD" gene 231301..233760 /gene="MEF2" /locus_tag="YJL102W" mRNA 231301..233760 /gene="MEF2" /locus_tag="YJL102W" /product="Mef2p" CDS 231301..233760 /gene="MEF2" /locus_tag="YJL102W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:21414316]" /experiment="EXISTENCE:mutant phenotype:GO:0051881 regulation of mitochondrial membrane potential [PMID:21414316]" /note="Mitochondrial elongation factor involved in translational elongation" /codon_start=1 /product="mitochondrial elongation factor MEF2" /protein_id="DAA08698.1" /db_xref="SGD:S000003638" /translation="MWKWNVRRWAGARVNISKNRLSVINVGSRYLSTARSPLSKVRNI GIIAHIDAGKTTTTERMLYYAGISKHIGDVDTGDTITDFLEQERSRGITIQSAAISFP WRNTFAINLIDTPGHIDFTFEVIRALKVIDSCVVILDAVAGVEAQTEKVWKQSKSKPK ICFINKMDRMGASFNHTVNDLINKFMRGTTTKPVLVNIPYYRKQPTSNDYVFQGVIDV VNGKRLTWNPENPDEIIVDELDGTSLEQCNRCRESMIETLTEYDEDLVQHFLEEAEGD YSKVSAQFLNASIRKLTMKNMIVPVLCGASFKNIGVQPLLDAIVNYLPSPIEAELPEL NDKTVPMKYDPKVGCLVNNNKNLCIALAFKVITDPIRGKQIFIRIYSGTLNSGNTVYN STTGEKFKLGKLLIPHAGTSQPVNILTAGQIGLLTGSTVENNISTGDTLITHSSKKDG LKSLDKKKELTLKINSIFIPPPVFGVSIEPRTLSNKKSMEEALNTLITEDPSLSISQN DETGQTVLNGMGELHLEIAKDRLVNDLKADVEFGQLMVSYKETINSETNIETYESDDG YRFSLSLLPNSDALPNCLAYPLGVNENFLIMEKNGNWDKEWKYQVSFESILNSIIASC IVGLQRGGKIANFPLYACSIKINSDWSVPPDIETPQEILKITRNLIFKALNDLKPEKY NLLEPIMNLDLTIPQSDVGTVLQDLTGARKAQILSIEDESSVSNSGASTCNSPENSNR IYIPSDAVTTLHATKDKKNTQETSSNVKKIIKAKVPLREITTYTNKLRSLSQGRGEFN IEYSDMEKVTNDRLQSILHDL" gene 233939..234011 /locus_tag="YNCJ0008W" tRNA 233939..234011 /locus_tag="YNCJ0008W" /product="tRNA-Arg" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Arginine tRNA (tRNA-Arg), predicted by tRNAscan-SE analysis; one of 6 nuclear tRNA genes containing the tDNA-anticodon ACG (converted to ICG in the mature tRNA), decodes CGU, CGC, and probably CGA codons into arginine, one of 19 nuclear tRNAs for arginine" /db_xref="SGD:S000006702" gene complement(234320..236356) /gene="GSH1" /locus_tag="YJL101C" mRNA complement(234320..236356) /gene="GSH1" /locus_tag="YJL101C" /product="glutamate--cysteine ligase" CDS complement(234320..236356) /gene="GSH1" /locus_tag="YJL101C" /EC_number="6.3.2.2" /experiment="EXISTENCE:direct assay:GO:0004357 glutamate-cysteine ligase activity [PMID:1687097]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:2184310]" /experiment="EXISTENCE:direct assay:GO:0006750 glutathione biosynthetic process [PMID:1687097]" /experiment="EXISTENCE:direct assay:GO:0046686 response to cadmium ion [PMID:10921921]" /experiment="EXISTENCE:mutant phenotype:GO:0004357 glutamate-cysteine ligase activity [PMID:2184310]" /experiment="EXISTENCE:mutant phenotype:GO:0006750 glutathione biosynthetic process [PMID:8768524]" /experiment="EXISTENCE:mutant phenotype:GO:0042542 response to hydrogen peroxide [PMID:7615092]" /note="Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="glutamate--cysteine ligase" /protein_id="DAA08699.1" /db_xref="SGD:S000003637" /translation="MGLLALGTPLQWFESRTYNEHIRDEGIEQLLYIFQAAGKRDNDP LFWGDELEYMVVDFDDKERNSMLDVCHDKILTELNMEDSSLCEANDVSFHPEYGRYML EATPASPYLNYVGSYVEVNMQKRRAIAEYKLSEYARQDSKNNLHVGSRSVPLTLTVFP RMGCPDFINIKDPWNHKNAASRSLFLPDEVINRHVRFPNLTASIRTRRGEKVCMNVPM YKDIATPETDDSIYDRDWFLPEDKEAKLASKPGFIYMDSMGFGMGCSCLQVTFQAPNI NKARYLYDALVNFAPIMLAFSAAAPAFKGWLADQDVRWNVISGAVDDRTPKERGVAPL LPKYNKNGFGGIAKDVQDKVLEIPKSRYSSVDLFLGGSKFFNRTYNDTNVPINEKVLG RLLENDKAPLDYDLAKHFAHLYIRDPVSTFEELLNQDNKTSSNHFENIQSTNWQTLRF KPPTQQATPDKKDSPGWRVEFRPFEVQLLDFENAAYSVLIYLIVDSILTFSDNINAYI HMSKVWENMKIAHHRDAILFEKFHWKKSFRNDTDVETEDYSISEIFHNPENGIFPQFV TPILCQKGFVTKDWKELKHSSKHERLYYYLKLISDRASGELPTTAKFFRNFVLQHPDY KHDSKISKSINYDLLSTCDRLTHLDDSKGELTSFLGAEIAEYVKKNKPSIESKC" gene 237263..239086 /gene="LSB6" /locus_tag="YJL100W" mRNA 237263..239086 /gene="LSB6" /locus_tag="YJL100W" /product="1-phosphatidylinositol 4-kinase LSB6" CDS 237263..239086 /gene="LSB6" /locus_tag="YJL100W" /EC_number="2.7.1.67" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:12523934|PMID:26928762|PMID:12361950]" /experiment="EXISTENCE:direct assay:GO:0004430 1-phosphatidylinositol 4-kinase activity [PMID:12361950|PMID:12523934]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12523934|PMID:12361950]" /experiment="EXISTENCE:direct assay:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:12361950|PMID:12523934]" /experiment="EXISTENCE:mutant phenotype:GO:0004430 1-phosphatidylinositol 4-kinase activity [PMID:12361950]" /experiment="EXISTENCE:mutant phenotype:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:12361950]" /note="Type II phosphatidylinositol 4-kinase; binds Las17p, a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization" /codon_start=1 /product="1-phosphatidylinositol 4-kinase LSB6" /protein_id="DAA08700.1" /db_xref="SGD:S000003636" /translation="MSNEAYQHDHTVNPHQKIVVNSYDWLQFRDEQDHCKSKNPITHA SPGVGSNAQNSDIAEAPQVFHPSYQSLVNVPSESPRPDQTSGSNPAVGLLHNAEDKAS GQEEEGSQYEIQYSVFRPLHAYPTKGLAYEQLRRKEEQEQRENFNHLVSDCIEAVETF GRELERIQTGSSGSYFVYGTRADESVPVGVFKPKDEEPYGPFSPKWTKWAHRTFFPCL FGRSCLIPNLGYICESAASLLDRRLETHLVPYTDTASIESFNFYDNRKKWVLGYNLQK KKQKKLGSFQLFLKEYINADEFFHKYPLPGMYSDVKHSFHRKSSGEDINHKPETTRNL TDETEPSKQINSSPISTESEENSKFEWTESSLSQFRLELEKLIILDYIMRNTDRGLDN WMVKLIKLSNNKWRLKLAAIDNGLSFPWKHPDEWRLYPYGWLYLPLQLLAKPFSEQMR SHFLPILTSTNWWEESYQEFLALFSRDQDFNVRMWKKQWAVLKGQAFNVVETLKDPRQ GPLELVRRTRCQVIDEKMQVPCCPPPVSIFKNAIDEPIGSYSTSPMVLPSTPSTIPFH AHNQSNSNPVYYDSTLHPFANKTVIAERLQIVNSTPVFTWC" gene 239414..241654 /gene="CHS6" /locus_tag="YJL099W" /gene_synonym="CSD3" mRNA 239414..241654 /gene="CHS6" /locus_tag="YJL099W" /gene_synonym="CSD3" /product="Chs6p" CDS 239414..241654 /gene="CHS6" /locus_tag="YJL099W" /gene_synonym="CSD3" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030140 trans-Golgi network transport vesicle [PMID:16498409]" /experiment="EXISTENCE:direct assay:GO:0034044 exomer complex [PMID:23000721|PMID:17000877]" /experiment="EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:16498409]" /experiment="EXISTENCE:mutant phenotype:GO:0006031 chitin biosynthetic process [PMID:9614194]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:11879634|PMID:9614194]" /note="Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; primary component of the Chs5/6 complex that binds directly to membranes; CHS6 has a paralog, BCH2, that arose from the whole genome duplication" /codon_start=1 /product="Chs6p" /protein_id="DAA08701.1" /db_xref="SGD:S000003635" /translation="MNLFWPSETKKQNEIPGGDYTPGNSPSVQKGYQFLNRDIFKSCP RIMERQFGECLHNRTHLIKDLISSGNVGLGPIEIVHMSYLNKHEKEEFGEYFYVTGIE VSGPAMPVEFLEVLKSSKRISKNISNNIILTYCCFNFFSNLDIRIRYDADDTFQTTAI DCNKETTDLTMTEKMWEETFASSVIRAIITNTNPELKPPGLVECPFYVGKDTISSCKK IIELLCRFLPRSLNCGWDSTKSMQATIVNNYLMYSLKSFIAITPSLVDFTIDYLKGLT KKDPIHDIYYKTAMITILDHIETKELDMITILNETLDPLLSLLNDLPPRDADSARLMN CMSDLLNIQTNFLLNRGDYELALGVSNTSTELALDSFESWYNLARCHIKKEEYEKALF AINSMPRLRKNDGHLETMYSRFLTSNYYKKPLNGTREHYDLTAMEFTNLSGTLRNWKE DELKRQIFGRIAMINEKKIGYTKEIWDDIAIKLGPICGPQSVNLINYVSPQEVKNIKN INLIARNTIGKQLGWFSGKIYGLLMEIVNKIGWNGLLNIRTEAFMMETEFYQASNNII DENGHIPMESRKKRFCEGWLDDLFLDLYQDLKLSKISLSNKDEKHSGLEWELLGLIML RTWHWEDAVACLRTSIVARFDPVSCQQLLKIYLQPPKNIQEVTLLDTDTIISLLIKKI SYDCRYYNYCQIFNLQLLEKLCNELGTHILRNKILLQPSIGDEIMVMIDAMLAWIADL DHTVQP" gene 242082..245258 /gene="SAP185" /locus_tag="YJL098W" mRNA 242082..245258 /gene="SAP185" /locus_tag="YJL098W" /product="Sap185p" CDS 242082..245258 /gene="SAP185" /locus_tag="YJL098W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:1903766 positive regulation of potassium ion export across plasma membrane [PMID:15947196]" /experiment="EXISTENCE:genetic interaction:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:8649382]" /experiment="EXISTENCE:mutant phenotype:GO:1903766 positive regulation of potassium ion export across plasma membrane [PMID:15947196]" /note="Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication" /codon_start=1 /product="Sap185p" /protein_id="DAA08702.1" /db_xref="SGD:S000003634" /translation="MSGSFWKFGQDFGSQSPLAKLLNRAFIKIDDKPTSTEAGKIDSN STDESLESNSFKSEDEEEEYELPNREEDYKAYKPNLSLLNDLLDDEELYTELMCSNFK LLVYLKYPEVLSKLIDYVRNSTILESNIDRVTSEDRDLVRGEDKDTTEDFENAKADKK NIDGTFEEKERTRSGEEEELENEENDSASEDTRVTLPHELEEHDDTRRARIAAEILSA DVWPISSALIENEGLLAKLWSILRLPSPLSIEASTYFMKINERLLDMNMDGIIEFILK KEHIVDDFLAHIDNPPLMDFLLKVISTDKPEISNGVIQLFKKQNLVPKLIHLLDPVFD SCTQSAAGDFLKALVTISGNCPNEITSSIGPNELTRQLVSPNMMKQLMDIMLKGGNSL NNGVGIIIELIRKNNSDYDTIQTNYTTIESHPPTDRDPIYLGYLVKMFSEHMADFNKI LTEKKIPLLQTSYGTIEPLGFERFKICELIAELLHCSNMTLLNEPSAYDIVRERDAER ERIFNSQNYVDSNDRSELKENEDDNTGDADDEVEDDTNQVESANTSIDGEEVIDKLNS LQIETNKVNQNMNNEEQHSLMPDFNNGDFKDEEDENPFEPQYSDVILDSSDIEKNFRV SPNVGDQLKISLQDTRVIDTMLEMFFHFQWNNFLHNVVYDVVQQIFNGPLKIGYNRFL LDDLLINIRLTDMIINGNNECIEYEKGHDTRLGYMGHLTLIAEEVTKFTAYIEEMNIT FENTEVMSSLFESKWIAYTEDVLEDLKEKYNAILGDIAEEGDMLQDEEEDAVYDKGER TMGTVDDYINDIMQMDNVRCQEEEEDEGEGYVSFDEDEPQEYRNGDSVRSKESNSSEG KRDQEQLYYEYVNEDGTKTRLNFNPDSDATEQVPGEVNRDHKIPLKLKRSFTDACKSE TIPNNTVNAKEESVFQFSNELSDGWESSPSNSIPKRASPSKNGMNSPMFQHQFELHSP TDEFGGHKDEILSAEGHDYDIDEYDELSDDSDEEYDNCEDEDSLDYADSAAYALCRSK SKDKISWDEEEQARLMGVVKFNSEHYRD" gene 245591..246244 /gene="PHS1" /locus_tag="YJL097W" mRNA 245591..246244 /gene="PHS1" /locus_tag="YJL097W" /product="enoyl-CoA hydratase PHS1" CDS 245591..246244 /gene="PHS1" /locus_tag="YJL097W" /EC_number="4.2.1.134" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:23708375|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0004300 enoyl-CoA hydratase activity [PMID:18272525]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:18272525]" /experiment="EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:14690591]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:16943325]" /experiment="EXISTENCE:mutant phenotype:GO:0018812 3-hydroxyacyl-CoA dehydratase activity [PMID:23416297]" /experiment="EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:18272525]" /experiment="EXISTENCE:mutant phenotype:GO:0030497 fatty acid elongation [PMID:23416297]" /note="Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane; involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking" /codon_start=1 /product="enoyl-CoA hydratase PHS1" /protein_id="DAA08703.1" /db_xref="SGD:S000003633" /translation="MSKKLASPLSFLPLYNLLSAVGWSYLLYLVISLYPKVGQPAFFY QTKNVATLVQCGAIIEIINSFLGVVRSPLLTTVAQVSSRLLVVLGIFQLLPNTSGVQS VVYISLLLAWSITEIVRYLYYFFMLVFKNGAPKILILLRYNLFWILYPTGVASELRII YCALNAAESQYSLLYKRILIAAMLAYIPGFPMLFLHMVAQRKKVMKSLRSSFGKKLI" gene 246490..246975 /gene="MRPL49" /locus_tag="YJL096W" /gene_synonym="bL21m" mRNA 246490..246975 /gene="MRPL49" /locus_tag="YJL096W" /gene_synonym="bL21m" /product="mitochondrial 54S ribosomal protein YmL49" CDS 246490..246975 /gene="MRPL49" /locus_tag="YJL096W" /gene_synonym="bL21m" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978|PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit" /codon_start=1 /product="mitochondrial 54S ribosomal protein YmL49" /protein_id="DAA08704.1" /db_xref="SGD:S000003632" /translation="MLQLKFIWPVARITPIYRPFTSHPFRNLATSSSISSTKAKTTKT DTTPLKLSNELYAIFKIHNRPYLVTEGDRVILPFKLKQAEVGDILNMTDVTTLGSRNY KLVGHPINTSLYTLKATVVGKTKRAFQTREVTKRRNRRVRHAKSKGDLTILRISELSM N" misc_feature 247060..247082 /note="ETC3; Chromosome-organizing-clamp; tethers chromosomal regions to the nuclear periphery; binds TFIIIC transcription factor but does not recruit RNA Polymerase III; located between MRPL49 and BCK1" /db_xref="SGD:S000077074" gene 247255..251691 /gene="BCK1" /locus_tag="YJL095W" /gene_synonym="LAS3" /gene_synonym="SAP3" /gene_synonym="SLK1" /gene_synonym="SSP31" mRNA 247255..251691 /gene="BCK1" /locus_tag="YJL095W" /gene_synonym="LAS3" /gene_synonym="SAP3" /gene_synonym="SLK1" /gene_synonym="SSP31" /product="mitogen-activated protein kinase kinase kinase BCK1" CDS 247255..251691 /gene="BCK1" /locus_tag="YJL095W" /gene_synonym="LAS3" /gene_synonym="SAP3" /gene_synonym="SLK1" /gene_synonym="SSP31" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0000196 cell integrity MAPK cascade [PMID:8386320|PMID:1729597]" /experiment="EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:1729597]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:20385774]" /experiment="EXISTENCE:mutant phenotype:GO:0004709 MAP kinase kinase kinase activity [PMID:11283616]" /experiment="EXISTENCE:mutant phenotype:GO:0010447 response to acidic pH [PMID:16087742]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:1545797]" /experiment="EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:16380504]" /experiment="EXISTENCE:mutant phenotype:GO:0035556 intracellular signal transduction [PMID:8190082]" /experiment="EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:1729597]" /note="MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase" /codon_start=1 /product="mitogen-activated protein kinase kinase kinase BCK1" /protein_id="DAA08705.1" /db_xref="SGD:S000003631" /translation="MPFLRKIAGTAHTHSRSDSNSSVKFGHQPTSSVASTKSSSKSPR ATSRKSIYDDIRSQFPNLTPNSTSSQFYESTPVIEQSFNWTTDDHISAGTLENPTSFT NSSYKNDNGPSSLSDSRKSSGGNSVNSLSFDKLILSWDPTDPDEWTMHRVTSWFKFHD FPESWILFFKKHQLFGHRFIKLLAYDNFAVYEKYLPQTKTASYTRFQQLLKKTMTKNV TNSHIRQKSASKLKSSRSSSESIKSKLKNSKSQEDISNSRSTSESALSPTKSGPSKTD EKNFLHSTSTHQKTKSASSLYRRSFISLRGSSSSNASSAKSPSNIKLSIPARPHSIIE SNSTLTKSASPPASPSYPSIFRRHHKSSSSESSLLNSLFGSGIGEEAPTKPNPQGHSL SSENLAKGKSKHYETNVSSPLKQSSLPTSDDKGNLWNKFKRKSQIGVPSPNTVAYVTS QETPSLKSNSSTATLTVQTADVNIPSPSSSPPPIPKTANRSLEVISTEDTPKISSTTA SFKETYPDCINPDKTVPVPVNNQKYSVKNFLLDQKFYPLKKTGLNDSENKYILVTKDN VSFVPLNLKSVAKLSSFKESALTKLGINHKNVTFHMTDFDCDIGAAIPDDTLEFLKKS LFLNTSGKIYIKDQMKLQQKPKPAPLTSENNVPLKSVKSKSSMRSGTSSLIASTDDVS IVTSSSDITSFDEHASGSGRRYPQTPSYYYDRVSNTNPTEELNYWNIKEVLSHEENAP KMVFKTSPKLELNLPDKGSKLNIPTPITENESKSSFQVLRKDEGTEIDFNHRRESPYT KPELAPKREAPKPPANTSPQRTLSTSKQNKPIRLVRASTKISRSKRSKPLPPQLLSSP IEASSSSPDSLTSSYTPASTHVLIPQPYKGANDVMRRLKTDQDSTSTSPSLKMKQKVN RSNSTVSTSNSIFYSPSPLLKRGNSKRVVSSTSAADIFEENDITFADAPPMFDSDDSD DDSSSSDDIIWSKKKTAPETNNENKKDEKSDNSSTHSDEIFYDSQTQDKMERKMTFRP SPEVVYQNLEKFFPRANLDKPITEGIASPTSPKSLDSLLSPKNVASSRTEPSTPSRPV PPDSSYEFIQDGLNGKNKPLNQAKTPKRTKTIRTIAHEASLARKNSVKLKRQNTKMWG TRMVEVTENHMVSINKAKNSKGEYKEFAWMKGEMIGKGSFGAVYLCLNVTTGEMMAVK QVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAG GSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKIS DFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKR PWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLS HPFSEVNETFNFKSTRLAKFIKSNDKLNSSKLRITSQENKTE" gene complement(251821..254442) /gene="KHA1" /locus_tag="YJL094C" mRNA complement(251821..254442) /gene="KHA1" /locus_tag="YJL094C" /product="Kha1p" CDS complement(251821..254442) /gene="KHA1" /locus_tag="YJL094C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:15926887]" /experiment="EXISTENCE:mutant phenotype:GO:0015386 potassium:proton antiporter activity [PMID:9811642]" /experiment="EXISTENCE:mutant phenotype:GO:0098662 inorganic cation transmembrane transport [PMID:9811642]" /note="Putative K+/H+ antiporter; involved in intracellular cation homeostasis; promotes copper binding to Fet3p multicopper oxidase; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies" /codon_start=1 /product="Kha1p" /protein_id="DAA08706.1" /db_xref="SGD:S000003630" /translation="MANTVGGILSGVNPFHYNSSSPLTLFLFQACLILLVCNLIHIPF SMMRQPKVISEVISGVILGPTIFGQIPNYTNTIFPTSSIPGLNLVANLGIILFMFFLG LEVDIAFIKKHLKKALVIGIVTLAVPFGFGCLLAIPLFHTYANKTEGERHIKFSVFMV FIAVSISVTAFPVLCRILNELRLIKDRAGIVVLAAGIINDIMGWILLALSIILSSAEG SPVNTVYILLITFAWFLIYFFPLKYLLRWVLIRTHELDRSKPSPLATMCILFIMFISA YFTDIIGVHPIFGAFIAGLVVPRDDHYVVKLTERMEDIPNIVFIPIYFAVAGLNVDLT LLNEGRDWGYVFATIGIAIFTKIISGTLTAKLTGLFWREATAAGVLMSCKGIVEIVVL TVGLNAGIISRKIFGMFVLMALVSTFVTTPLTQLVYPDSYRDGVRKSLSTPAEDDGAA DGLDSEGVDKTEINTQLNSLADVSKYRIGELTTVINTTEAISPSLKLLNYLSLGVSPK PKNNKHKNETSLSRMTTATDSTLKSNTFKIKKMVHIWSKSVDDVDTNLSVIDEKLTPF EGVGALRAIHLRLLTERTTDLLQSSSLYNDDPHFTANTDSLLQIFDIFSNLSKIPFSS EVIFSTMREKAANIATMKMDSTDLILLPLKGASYEYRGSPVFIDEKYANFDHIYSHLL GLNELSSTFFKSIFQSLKANFAVQISNTYGRLNADRFKRKRFNLLLPKPYLTQSDYLG LYLLLLICYRDGYNNDNASCSIFINSKNIDFAKDLSTAFAEHDWLNESTIKIVDIPFE TKVPEEAIEKPSFIETVLDVGLSDTALADIEETTFIIGEDLPDESEPFSEEVRTVIFE GSNRRFDTLIVHHFSSE" gene complement(254737..256812) /gene="TOK1" /locus_tag="YJL093C" /gene_synonym="DUK1" /gene_synonym="YKC1" /gene_synonym="YPK1" mRNA complement(254737..256812) /gene="TOK1" /locus_tag="YJL093C" /gene_synonym="DUK1" /gene_synonym="YKC1" /gene_synonym="YPK1" /product="Tok1p" CDS complement(254737..256812) /gene="TOK1" /locus_tag="YJL093C" /gene_synonym="DUK1" /gene_synonym="YKC1" /gene_synonym="YPK1" /experiment="EXISTENCE:direct assay:GO:0005267 potassium channel activity [PMID:7651518]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:7651518]" /experiment="EXISTENCE:direct assay:GO:0030007 intracellular potassium ion homeostasis [PMID:7651518]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005249 voltage-gated potassium channel activity [PMID:16133265]" /experiment="EXISTENCE:mutant phenotype:GO:0005267 potassium channel activity [PMID:7651518]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:7651518]" /experiment="EXISTENCE:mutant phenotype:GO:0030007 intracellular potassium ion homeostasis [PMID:7651518]" /note="Outward-rectifier potassium channel of the plasma membrane; has two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin" /codon_start=1 /product="Tok1p" /protein_id="DAA08707.1" /db_xref="SGD:S000003629" /translation="MTRFMNSFAKQTLGYGNMATVEQESSAQAVDSHSNNTPKQAKGV LAEELKDALRFRDERVSIINAEPSSTLFVFWFVVSCYFPVITACLGPVANTISIACVV EKWRSLKNNSVVTNPRSNDTDVLMNQVKTVFDPPGIFAVNIISLVLGFTSNIILMLHF SKKLTYLKSQLINITGWTIAGGMLLVDVIVCSLNDMPSIYSKTIGFWFACISSGLYLV CTIILTIHFIGYKLGKYPPTFNLLPNERSIMAYTVLLSLWLIWGAGMFSGLLHITYGN ALYFCTVSLLTVGLGDILPKSVGAKIMVLIFSLSGVVLMGLIVFMTRSIIQKSSGPIF FFHRVEKGRSKSWKHYMDSSKNLSEREAFDLMKCIRQTASRKQHWFSLSVTIAIFMAF WLLGALVFKFAENWSYFNCIYFCFLCLLTIGYGDYAPRTGAGRAFFVIWALGAVPLMG AILSTVGDLLFDISTSLDIKIGESFNNKVKSIVFNGRQRALSFMVNTGEIFEESDTAD GDLEENTTSSQSSQISEFNDNNSEENDSGVTSPPASLQESFSSLSKASSPEGILPLEY VSSAEYALQDSGTCNLRNLQELLKAVKKLHRICLADKDYTLSFSDWSYIHKLHLRNIT DIEEYTRGPEFWISPDTPLKFPLNEPHFAFMMLFKNIEELVGNLVEDEELYKVISKRK FLGEHRKTL" gene 257423..260947 /gene="SRS2" /locus_tag="YJL092W" /gene_synonym="HPR5" mRNA 257423..260947 /gene="SRS2" /locus_tag="YJL092W" /gene_synonym="HPR5" /product="DNA helicase SRS2" CDS 257423..260947 /gene="SRS2" /locus_tag="YJL092W" /gene_synonym="HPR5" /EC_number="5.6.2.4" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19506039]" /experiment="EXISTENCE:direct assay:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:10908335]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:25765656]" /experiment="EXISTENCE:direct assay:GO:0032508 DNA duplex unwinding [PMID:18440969]" /experiment="EXISTENCE:direct assay:GO:0043138 3'-5' DNA helicase activity [PMID:8419328]" /experiment="EXISTENCE:direct assay:GO:1990986 DNA recombinase disassembly [PMID:12748644|PMID:12748645]" /experiment="EXISTENCE:direct assay:GO:2000042 negative regulation of double-strand break repair via homologous recombination [PMID:19595720]" /experiment="EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:7768432]" /experiment="EXISTENCE:mutant phenotype:GO:0007127 meiosis I [PMID:23770697]" /experiment="EXISTENCE:mutant phenotype:GO:0042262 DNA protection [PMID:31168653]" /experiment="EXISTENCE:mutant phenotype:GO:0045910 negative regulation of DNA recombination [PMID:23770697]" /experiment="EXISTENCE:mutant phenotype:GO:1990986 DNA recombinase disassembly [PMID:23770697]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:31142613]" /note="DNA helicase and DNA-dependent ATPase; role in DNA repair and checkpoint recovery, in the proper timing of commitment to meiotic recombination and the Meiosis I to II transition; blocks trinucleotide repeat expansion; affects genome stability; disassembles Rad51p nucleoprotein filaments during meiotic recombination; stimulates Mus81p-Mms4p endonuclease activity independent of catalytic activity; ATPase and ssDNA translocating motor activities inhibited by Dmc1p; functional homolog of human RTEL1" /codon_start=1 /product="DNA helicase SRS2" /protein_id="DAA08708.1" /db_xref="SGD:S000003628" /translation="MSSNNDLWLHLVSQLNTQQRAAALFDYTRGLQVIAGPGTGKTKV LTSRVAYLILHHHIHPRDIIVTTFTNKAANEMKERLQEMLRGAGVNISELLIGTFHSI CLKILYRFGHLVDLQKDWRIIDEKEIDVILDDMIEKVPDQIRDYASSITRKVNLCMPS KNGDEWTIHPKLIKKQISKLKSNAILPEEYILDSNHDAALGYFYQIYQSELSKKNTLD FDDLLMYTFRLLTRVRVLSNIKHVLVDEFQDTNGIQLDLMFLFAKGNHHLSRGMTIVG DPDQSIYAFRNALAHNFLEMGRKCPIEYSTIILVENYRSSQKILNTSEILITQQNKGR QNRAPLRAQFDLDFPPVYMNFPAYFLEAPSLVRELLYLKALPNLFTFNDFAILVRQRR QIKRIESALIEHRIPYKIIRGHSFWDSKETRAMLNLLKLIFSPNDKHAILASLLYPAR GLGPATGEKIKNALDTLATDVSCFQILKDISSKKIMLDIPTKGRSVIADFISMIENCQ LLLQSTLLGGLSDLFDKLYELSGLKYEYLYKDGKKKNDQLEKSEPNLLNARHKNIELL KNYFLALLSKSESSDKEKNEAIKAATDEAEPIENKVITPKEYLRNFFNSLSLHSDAAE EEESESNKDAKIKREKNGFVTISTIHGAKGLEWPVVFIPGCEEGIIPCVFNDDKKDES EEDEEEDQENSKKDASPKKTRVLSVEDSIDEERRMFFVAQTRAKYLLYLSNTVTVEDV DRPRIASRFLTTDLIKAMSDSQKLFESTNSIKKLYRILNKKPPAEDDKLFSLDQLRKD YNQFIENRRERMIWQGIQMNDVYGIQLSRNKLLGSVSDFTSAADQLRLETQNSIFPQK KLIEKSRPSKINGNYAPKSRVKSPEKRYAPETTSFHSPTKKKVYAPQYVSTTNVPSRQ EFHSSTGKNIPFLRREDRSITDISPRSSTRSLKGASPNKTSHMSDDLMRPSPTRKDKV TRNIHFATAGTFRIETQSNVDELHPPEYSNKSGQSLTSSEFSGFSSACSNSDQPTNLI EDINNELDLSDEELLNDISIERRRELLGSKKTKKIKPKTRNRKSKRGDKVKVEEVIDL KSEFEEDDSRNTTAAELLHNPDDTTVDNRPIISNAKFLADAAMKKTQKFSKKVKNEPA SSQMDIFSQLSRAKKKSKLNNGEIIVID" gene complement(261080..262552) /gene="GWT1" /locus_tag="YJL091C" mRNA complement(261080..262552) /gene="GWT1" /locus_tag="YJL091C" /product="glucosaminyl-phosphotidylinositol O-acyltransferase" CDS complement(261080..262552) /gene="GWT1" /locus_tag="YJL091C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006506 GPI anchor biosynthetic process [PMID:12714589]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:21367863]" /experiment="EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:14690591]" /experiment="EXISTENCE:genetic interaction:GO:0032216 glucosaminyl-phosphatidylinositol O-acyltransferase activity [PMID:14517336]" /experiment="EXISTENCE:mutant phenotype:GO:0032216 glucosaminyl-phosphatidylinositol O-acyltransferase activity [PMID:16361252]" /note="Protein involved in the inositol acylation of GlcN-PI; the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) forms glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors" /codon_start=1 /product="glucosaminyl-phosphotidylinositol O-acyltransferase" /protein_id="DAA08709.1" /db_xref="SGD:S000003627" /translation="MSTLKQRKEDFVTGLNGGSITEINAVTSIALVTYISWNLLKNSN LMPPGISSVQYIIDFALNWVALLLSITIYASEPYLLNTLILLPCLLAFIYGKFTSSSK PSNPIYNKKKMITQRFQLEKKPYITAYRGGMLILTAIAILAVDFPIFPRRFAKVETWG TSLMDLGVGSFVFSNGIVSSRALLKNLSLKSKPSFLKNAFNALKSGGTLLFLGLLRLF FVKNLEYQEHVTEYGVHWNFFITLSLLPLVLTFIDPVTRMVPRCSIAIFISCIYEWLL LKDDRTLNFLILADRNCFFSANREGIFSFLGYCSIFLWGQNTGFYLLGNKPTLNNLYK PSTQDVVAASKKSSTWDYWTSVTPLSGLCIWSTIFLVISQLVFQYHPYSVSRRFANLP YTLWVITYNLLFLTGYCLTDKIFGNSSEYYKVAECLESINSNGLFLFLLANVSTGLVN MSMVTIDSSPLKSFLVLLAYCSFIAVISVFLYRKRIFIKL" gene complement(262757..265051) /gene="DPB11" /locus_tag="YJL090C" mRNA complement(262757..265051) /gene="DPB11" /locus_tag="YJL090C" /product="protein kinase activating protein DPB11" CDS complement(262757..265051) /gene="DPB11" /locus_tag="YJL090C" /experiment="EXISTENCE:direct assay:GO:0000725 recombinational repair [PMID:16840526]" /experiment="EXISTENCE:direct assay:GO:0001934 positive regulation of protein phosphorylation [PMID:18842580|PMID:18922789]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005657 replication fork [PMID:10733584]" /experiment="EXISTENCE:direct assay:GO:0030295 protein kinase activator activity [PMID:18922789]" /experiment="EXISTENCE:direct assay:GO:0070182 DNA polymerase binding [PMID:10733584]" /experiment="EXISTENCE:genetic interaction:GO:0000725 recombinational repair [PMID:16840526]" /experiment="EXISTENCE:genetic interaction:GO:0007095 mitotic G2 DNA damage checkpoint signaling [PMID:18541674]" /experiment="EXISTENCE:mutant phenotype:GO:0000076 DNA replication checkpoint signaling [PMID:10097122]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:10733584|PMID:23629628]" /experiment="EXISTENCE:mutant phenotype:GO:0007533 mating type switching [PMID:21130053]" /experiment="EXISTENCE:mutant phenotype:GO:0031261 DNA replication preinitiation complex [PMID:17167415]" /experiment="EXISTENCE:mutant phenotype:GO:1902597 positive regulation of DNA replication origin binding [PMID:10733584]" /note="DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; along with Rfa1p, binds to ultrafine anaphase bridges in mitotic cells and prevents accumulation of chromatin bridges by stimulating the Mec1p kinase and suppressing homologous recombination; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress" /codon_start=1 /product="protein kinase activating protein DPB11" /protein_id="DAA08710.1" /db_xref="SGD:S000003626" /translation="MKPFQGITFCPTAINNEILAKKISKKIIKLGGIFSKDLTRQVNV LVVGSTTNTNKFKFAVKHRFDIIFIDIQAIDDIYQLWLSGENILPDSNTATMTGSTYE MLKILYRRFSFKYLHNFNIFIGRITDTNITSIDSLVRSIKKLGCSSYNYQNFVIKDTS SHNDDDDQGQNGQISIFVTDTLLGARVNAAIEQNIPIVHFKWILDCQKRSALLPYDPY YLLPNIKDLPYDSIGSNSCDCWDKINTTFPTNIDAQSSLQRQQSSSTLTPSLPKTSSL LNKFKPKGEKIWDKAMSLQQHSKTNFSVLGQSPLSINNKQEDLSDNSTLIFKNCAFII HHIFPGNHRSILTKIVVQNGGKIETSYLSGIYDHSYYIIPSNKALDSFNDLPEIIDDN DGIVTEFFIERCLYYQKLLHPIDLWSKPFLSTIEFQVSSSSKLLHHEFSSSPFLNVTI TGFSGVELLHLTKVLNLLKPMGINYVEYLNKSTDILLINLAALPSIPKTHPLWSNEFS DLFTQFCINNNNDDPGDNNRKDFQNNSILRNSMKRKIEYIKKFHSIPVVTPAFIFKLL SAASGENNEIFLNNIKWCIICPRGHKDDFKCKIKKPYYTSISSEKKYQNNDPKIDKTI LLKRNNSSLSEHSMKDTKNELLQKIRETDSGRKKRSVSSSIMDVSSERQMPDTKRIKL ESLPKNFVPKQIKRTTSWGTIMSENVPTEQPTAISNPEEIPRTEEVSHTQVTYGSIQD KKRTASLEKPMRRQTRNQTKELDS" gene 265926..268415 /gene="SIP4" /locus_tag="YJL089W" mRNA 265926..268415 /gene="SIP4" /locus_tag="YJL089W" /product="Sip4p" CDS 265926..268415 /gene="SIP4" /locus_tag="YJL089W" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:14685767|PMID:11405098|PMID:9843506]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:14685767]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9843506|PMID:11331606]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:genetic interaction:GO:0045722 positive regulation of gluconeogenesis [PMID:25123508]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:25123508]" /experiment="EXISTENCE:mutant phenotype:GO:0045722 positive regulation of gluconeogenesis [PMID:9843506]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9843506]" /experiment="EXISTENCE:mutant phenotype:GO:2000218 negative regulation of invasive growth in response to glucose limitation [PMID:11095711]" /experiment="EXISTENCE:physical interaction:GO:0045722 positive regulation of gluconeogenesis [PMID:9843506]" /note="C6 zinc cluster transcriptional activator; binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus" /codon_start=1 /product="Sip4p" /protein_id="DAA08711.1" /db_xref="SGD:S000003625" /translation="MAKRKYGRSYSLDDTDSCSNKVLIVPTGQSSSNAITDFSVRKAH ACDRCRLKKIKCDGLKPNCSNCAKIDFPCKTSDKLSRRGLPKGYTELLEKEVVRLTNM NASSSANANSNLPFINDTFYCFDNYNTQSENQRFLGHLTWNILTNTFPTQKAVVFTDD RNNIDLQLQLLTNFLNLNGDFNHLPNFLLLKYDYNLQFLKNLLSVIIKDFFKRQNSLL LLLYPTNLWKNLLLDKINSTAMTGEPITLLALLYIIQFTWSCFDDFKLFKVTKLIVSL TTNSKLDLKVLQLVNLSIFYFMGASVDSCKSKSSLTEHSNVNSVIWTNDLLNLNFTNI LNMGLYINPKNLIPISGNNNNNKSNEEDDRIVTFWCFQFLSSWWSLIQGLPKSNFLTE EFQPKSISVLEIPRLKPFEILLNFIIYSLDGCNLLNISSLNVSDPNFQFFQNELESFK KNLLLWNLYHNLSDHDNFRFLTSSSNKKLTTNLLLKNLTGLNHKLNQPDFVEIQLTLF YLSLKLMTLKEGDQDLKKEDISLEILSLYFLILTDDSNNDDNQQLQPQQLNLYHFTPF NSIDIIDLCLNNLNNWSLSLKYESGQNQPHSSKIKFEKFQNFLNHWCPIWYYDEFSTN PFLQILKINFKLLPFETIHYSQEEQRLLISLNKLRYLDAVSSFNSSSVKSNFASKVNT QLNLLQHSSSNSNFLDASPYDFNKIFMNNFENYDYETDEGYAEDDDEEDSDSDNSLPL EIPFKKSKNKCKNRNKELSQRLSLFENRDSNSVDFNTDTNLNLNPDSPSVTSSKKKYL DHIILDNRDIVSNHDSSKQKFKIQNILNSTF" gene 268799..269815 /gene="ARG3" /locus_tag="YJL088W" mRNA 268799..269815 /gene="ARG3" /locus_tag="YJL088W" /product="ornithine carbamoyltransferase" CDS 268799..269815 /gene="ARG3" /locus_tag="YJL088W" /EC_number="2.1.3.3" /experiment="EXISTENCE:direct assay:GO:0004585 ornithine carbamoyltransferase activity [PMID:7029528]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:205532]" /experiment="EXISTENCE:mutant phenotype:GO:0006526 L-arginine biosynthetic process [PMID:2897249]" /note="Ornithine carbamoyltransferase; also known as carbamoylphosphate:L-ornithine carbamoyltransferase; catalyzes the biosynthesis of the arginine precursor citrulline" /codon_start=1 /product="ornithine carbamoyltransferase" /protein_id="DAA08712.1" /db_xref="SGD:S000003624" /translation="MSTTASTPSSLRHLISIKDLSDEEFRILVQRAQHFKNVFKANKT NDFQSNHLKLLGRTIALIFTKRSTRTRISTEGAATFFGAQPMFLGKEDIQLGVNESFY DTTKVVSSMVSCIFARVNKHEDILAFCKDSSVPIINSLCDKFHPLQAICDLLTIIENF NISLDEVNKGINSKLKMAWIGDANNVINDMCIACLKFGISVSISTPPGIEMDSDIVDE AKKVAERNGATFELTHDSLKASTNANILVTDTFVSMGEEFAKQAKLKQFKGFQINQEL VSVADPNYKFMHCLPRHQEEVSDDVFYGEHSIVFEEAENRLYAAMSAIDIFVNNKGNF KDLK" gene complement(270002..272485) /gene="TRL1" /locus_tag="YJL087C" /gene_synonym="LIG1" /gene_synonym="RLG1" mRNA complement(270002..272485) /gene="TRL1" /locus_tag="YJL087C" /gene_synonym="LIG1" /gene_synonym="RLG1" /product="tRNA ligase" CDS complement(270002..272485) /gene="TRL1" /locus_tag="YJL087C" /gene_synonym="LIG1" /gene_synonym="RLG1" /EC_number="6.5.1.3" /experiment="EXISTENCE:direct assay:GO:0003972 RNA ligase (ATP) activity [PMID:3277966|PMID:3512545]" /experiment="EXISTENCE:direct assay:GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [PMID:6297798]" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:3312232]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:20844078]" /experiment="EXISTENCE:direct assay:GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation [PMID:2207062]" /experiment="EXISTENCE:direct assay:GO:0051730 GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity [PMID:8428918]" /experiment="EXISTENCE:mutant phenotype:GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation [PMID:1537841]" /experiment="EXISTENCE:mutant phenotype:GO:0032056 positive regulation of translation in response to stress [PMID:20844078]" /experiment="EXISTENCE:mutant phenotype:GO:0036498 IRE1-mediated unfolded protein response [PMID:8898194]" /experiment="EXISTENCE:mutant phenotype:GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay [PMID:31913314]" /experiment="EXISTENCE:mutant phenotype:GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:30874502]" /note="tRNA ligase; required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; involved in turnover of tRNA introns; localized at the inner nuclear envelope and cytoplasm" /codon_start=1 /product="tRNA ligase" /protein_id="DAA08713.1" /db_xref="SGD:S000003623" /translation="MPSPYDGKRTVTQLVNELEKAEKLSGRGRAYRRVCDLSHSNKKV ISWKFNEWDYGKNTITLPCNARGLFISDDTTNPVIVARGYDKFFNVGEVNFTKWNWIE ENCTGPYDVTIKANGCIIFISGLEDGTLVVCSKHSTGPRADVDRNHAEAGEKQLLRQL AAMNINRSDFARMLYTHNVTAVAEYCDDSFEEHILEYPLEKAGLYLHGVNVNKAEFET WDMKDVSQMASKYGFRCVQCITSNTLEDLKKFLDNCSATGSFEGQEIEGFVIRCHLKS TEKPFFFKYKFEEPYLMYRQWREVTKDYISNKSRVFKFRKHKFITNKYLDFAIPILES SPKICENYLKGFGVIELRNKFLQSYGMSGLEILNHEKVAELELKNAIDYDKVDERTKF LIFPISVIGCGKTTTSQTLVNLFPDSWGHIQNDDITGKDKSQLMKKSLELLSKKEIKC VIVDRNNHQFRERKQLFEWLNELKEDYLVYDTNIKVIGVSFAPYDKLSEIRDITLQRV IKRGNNHQSIKWDELGEKKVVGIMNGFLKRYQPVNLDKSPDNMFDLMIELDFGQADSS LTNAKQILNEIHKAYPILVPEIPKDDEIETAFRRSLDYKPTVRKIVGKGNNNQQKTPK LIKPTYISAKIENYDEIIELVKRCIASDAELTEKFKHLLASGKVQKELHITLGHVMSS REKEAKKLWKSYCNRYTDQITEYNNNRIENAQGSGNNQNTQVKTTDKLNFRLEKLCWD EKIIAIVVELSKDKDGCIIDENNEKIKGLCCQNKIPHITLCKLESGVKAVYSNVLCEK VESAEVDENIKVVKLDNSKEFVGSVYLNF" gene 272827..274698 /gene="EXO70" /locus_tag="YJL085W" mRNA 272827..274698 /gene="EXO70" /locus_tag="YJL085W" /product="GTP-Rho binding exocyst subunit EXO70" CDS 272827..274698 /gene="EXO70" /locus_tag="YJL085W" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:18195105]" /experiment="EXISTENCE:direct assay:GO:0000145 exocyst [PMID:8978675]" /experiment="EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:17717527]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17717527]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922|PMID:10207081|PMID:18946089|PMID:17717527]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922|PMID:18946089|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0007266 Rho protein signal transduction [PMID:19955214]" /experiment="EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:10588647]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:15583030|PMID:17717527]" /experiment="EXISTENCE:genetic interaction:GO:0007266 Rho protein signal transduction [PMID:19955214]" /experiment="EXISTENCE:genetic interaction:GO:0051601 exocyst localization [PMID:17717527|PMID:18946089]" /experiment="EXISTENCE:mutant phenotype:GO:0001927 exocyst assembly [PMID:18946089|PMID:15583030]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:17339375]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:17339375]" /experiment="EXISTENCE:physical interaction:GO:0007266 Rho protein signal transduction [PMID:19955214]" /experiment="EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:10207081|PMID:19955214]" /note="Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress" /codon_start=1 /product="GTP-Rho binding exocyst subunit EXO70" /protein_id="DAA08714.1" /db_xref="SGD:S000003621" /translation="MPAEIDIDEADVLVLSQELQKTSKLTFEINKSLKKIAATSNQSS QLFTPILARNNVLTTLQRNIESTLNSVASVKDLANEASKYEIILQKGINQVGLKQYTQ VVHKLDDMLEDIQSGQANREENSEFHGILTHLEQLIKRSEAQLRVYFISILNSIKPFD PQINITKKMPFPYYEDQQLGALSWILDYFHGNSEGSIIQDILVGERSKLILKCMAFLE PFAKEISTAKNAPYEKGSSGMNSYTEALLGFIANEKSLVDDLYSQYTESKPHVLSQIL SPLISAYAKLFGANLKIVRSNLENFGFFSFELVESINDVKKSLRGKELQNYNLLQDCT QEVRQVTQSLFRDAIDRIIKKANSISTIPSNNGVTEATVDTMSRLRKFSEYKNGCLGA MDNITRENWLPSNYKEKEYTLQNEALNWEDHNVLLSCFISDCIDTLAVNLERKAQIAL MPNQEPDVANPNSSKNKHKQRIGFFILMNLTLVEQIVEKSELNLMLAGEGHSRLERLK KRYISYMVSDWRDLTANLMDSVFIDSSGKKSKDKEQIKEKFRKFNEGFEDLVSKTKQY KLSDPSLKVTLKSEIISLVMPMYERFYSRYKDSFKNPRKHIKYTPDELTTVLNQLVR" gene complement(274862..278002) /gene="ALY2" /locus_tag="YJL084C" /gene_synonym="ART3" mRNA complement(274862..278002) /gene="ALY2" /locus_tag="YJL084C" /gene_synonym="ART3" /product="Aly2p" CDS complement(274862..278002) /gene="ALY2" /locus_tag="YJL084C" /gene_synonym="ART3" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005769 early endosome [PMID:20739461]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:20739461]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0051453 regulation of intracellular pH [PMID:38248315]" /experiment="EXISTENCE:mutant phenotype:GO:0032386 regulation of intracellular transport [PMID:20739461]" /experiment="EXISTENCE:mutant phenotype:GO:0070086 ubiquitin-dependent endocytosis [PMID:32800549]" /experiment="EXISTENCE:mutant phenotype:GO:1903577 cellular response to L-arginine [PMID:32800549]" /experiment="EXISTENCE:mutant phenotype:GO:2000397 positive regulation of ubiquitin-dependent endocytosis [PMID:20956561]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:20956561]" /experiment="EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:18976803]" /note="Alpha arrestin, Ub-ligase adaptor for Rsp5p; controls nutrient limitation-mediated endosomal recycling of the Gap1p amino acid permease; PY motif-containing adaptor involved in substrate-induced, Rsp5p-mediated ubiquitination and endocytosis of select plasma membrane localized amino acid transporters, such as Dip5p and Put4p; regulates intracellular pH; phosphorylated by Npr1p and by the Pcl7p-Pho85p cyclin-CDK complex; interacts with AP-1 subunit Apl4p" /codon_start=1 /product="Aly2p" /protein_id="DAA08715.1" /db_xref="SGD:S000003620" /translation="MPMDQSISSPLFPMEKDIDIPLDATPLAQSSSLQLFIHLAEPVV FLQGFDPQKTEYPSVVLRGCLVVRILKPTKLKSISLSFKGYSRTEWPEGIPPKRQEFV EIKDIVDHTWALYPPTEQKSKKKMDASAPNESNNAANNFLTKESGASLYRTLSDNETI TSRKNSISGLSSLNLSPLGAPGNSSVNVKDRESRQRSRSSSVTSSNGPSRNLSPINLL KRATSPSVSHHNYKPTTTSIFSDLLNNTFTHNDAASHHGHHIPTSSNHLAMTSNNFTS GSGGEFFVFQPGDYIYAFEELIPQAYPESIKADFGFVEYFLFASIERPGAFKSNISAR QVVNIVRTQAHNSVEESEPIIISRDWENQLYYDIVIASKDIILDAFLPITFKFAPLDK VTLHRIRIYVTETMEYYCREKKVHRMEPTKKFLLTEQKGPKLPNLPNDANLSKAKNMG NLLQDPKNGDLVNKEYEYQIFIPSRFNNHQQLHPDTSYENIKANHWIKICLRLSRVVD NKRKHYEISIDSPIHVLHRLCSHANTLLPSYDGHPASFPKETDSSISSILESSDDNIN LYHNSNIFFPKEVLSSPVLSPNVQPLDILIPHLPSTSLTRNSRQFNRNSKSHPSDNTI FNSAKLKSNIYQPESLQRELASPQAIPLSPITSPMSNMEVPPPDFDFSSDFISDAASG TTTTEVSSSESSILPRDPPSYKDTVLHDNNQKRRPNSKHPTPPSLKASHPNKNSDKNS SETLNKKESMSKIEENKHKRETTPKKRENRDVKSLSTPQREESKDSTSTGNQSNEKNR KRVLSLSSSLHSSPNNSGFAHSALGNLSNESLRSLNRRESVQDNLPSTIRHDNPFFTD LNQVLIEDELKNHDKNELNRHSTNTSSTPASARSSFDYSGINISKDKLNMEPLLSKTE TLTNKVNEDSFLRPNDSYVDLLEPSVDTTIDITAPYARNSSAWHPLQNDNDNNQFSPL LGSNENFLNAANAQNSAESDHNNDIFTQGSGLTESSKNSDSEERFISRLSSPEKVLIN TLDNESGLQSINESTL" gene 278841..280655 /gene="TAX4" /locus_tag="YJL083W" mRNA 278841..280655 /gene="TAX4" /locus_tag="YJL083W" /product="Tax4p" CDS 278841..280655 /gene="TAX4" /locus_tag="YJL083W" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:18298591]" /experiment="EXISTENCE:genetic interaction:GO:0006914 autophagy [PMID:18298591]" /experiment="EXISTENCE:genetic interaction:GO:0009267 cellular response to starvation [PMID:18298591]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:15265867]" /note="EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication" /codon_start=1 /product="Tax4p" /protein_id="DAA08716.1" /db_xref="SGD:S000003619" /translation="MHFPKKKHSGNLSVVELPKEALQDSLTAAQITFKRYAHPNGNAG SAERPRHLKVESAPVVKSEPSLPRMRQPEPRSINHQYSRETLPGHSEAFSVPTTPLQT IHYDVRNKASNSPSSIAAAETAAYLAHTNSFSNRSSGVGSRDPVMDTETKPPRAPSAL KNELQLNRMRIPPPSYDNNVRSRSISPQVSYSTSLSSSCSISSDGEETSYREKSTDEA FPPEPSMSSYSLASKASAKASLTDPSQRQQESDYTAMNKLNGGNIIYKGTLPDLIPRS QRKTSKPRFKHRLLRSPEQQQENLSRVYSDQTQNGRAIINTQQNVKLKTTMRRGKYAI TDNDETFPYDRKSVSSDSDTDEDSNVMEIKDKKKKSRRSKIKKGLKTTAAVVGSSTSV LPFPHHHHHHHQLHNPNSHHLHTHHHTSSHKFNEDKPWKSHRDLGFITEQERKRYESM WVSNRYSYLRLLPWWPSLANEDDESHLQPLNLPQDGLMLNLVVKDIWYRSNLPRDLLV QIYNMVDTRKDGTLDRKSFIVGMWLVDQCLYGRKLTNELDQRVWNSVDGYVLGTINVK PATSDHYHNANNPLDKPSKLSVRQELKNIKRDLRNVRI" gene 281185..283380 /gene="IML2" /locus_tag="YJL082W" mRNA 281185..283380 /gene="IML2" /locus_tag="YJL082W" /product="Iml2p" CDS 281185..283380 /gene="IML2" /locus_tag="YJL082W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:mutant phenotype:GO:0071218 cellular response to misfolded protein [PMID:26004510]" /note="Protein required for clearance of inclusion bodies; localizes to the inclusion bodies formed under protein misfolding stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication" /codon_start=1 /product="Iml2p" /protein_id="DAA08717.1" /db_xref="SGD:S000003618" /translation="MFRVFGSFGSKGNQSSGEEQSTKTKQVLKQANDFEIALKAMDFV LDDRTDEGLNLLKKAEMETGSDQTILTLARGVIEFLQATLSFETEEMKRAAITLGKAE QMSWKSKQNAEKTNFRSSSIYPPGTVYAVTYTESCLLHALLMLFSESMMEAAKALLKL RRAYTMLQDIMVTVKKAERSKNSSSPSPSEKSQESCGSFVSAETTFISVDIPYKLSSE DKSNPLLLEFAEKIYTMRMGRLSGAHIGNTPSFHRLRDDLGLQTTPSQASDRHSVSDD FDLEQATIDEFIHSGANLCYGILQVVLSLLPPAIGAVLSIVGFKGSREEGLRLVWKAT KERNVHGCIGLLGLMFYYDGPFQFTDADFDIPPNDNGSRALNKSRTNDSSLLPGYMDS ATLLHPGKILEDALLKARALFPNSALWLLNEAKMLAGKGRLRDSLALMDSIDVNSIRM RQVKSLMVFERAILLVNLHEYNRAADDLISLLDISDWSHALYTYFAGCCYLENWRMTQ LGLLNDGKEQFYKERARELIFDAPSLLGKKTFKSKNLPLDRFMLRKVQQFNNMQKKLN LQEPLDSIATSPVHELAYFYNGYNRMTENDLILTKKMLTEYHNPAIDSEDPDQELIRN LLLSLTLRRLGDAERGLALLDDIVLPKIFYIQNGKVKYFKKTEDPWAYPAALYERALF CWKLGGMESLNECREWLLRAQNYAADYELSTRIGMKIKAALDRVENALA" gene complement(283802..285271) /gene="ARP4" /locus_tag="YJL081C" /gene_synonym="ACT3" mRNA complement(283802..285271) /gene="ARP4" /locus_tag="YJL081C" /gene_synonym="ACT3" /product="Arp4p" CDS complement(283802..285271) /gene="ARP4" /locus_tag="YJL081C" /gene_synonym="ACT3" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10436015]" /experiment="EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:14690608|PMID:14645854|PMID:16299513]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10436015]" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:16088870]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11011149|PMID:10911987]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:12353039|PMID:16135807]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:14645854]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:10911987]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:10911987]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:10911987]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15610740]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:10436015]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:8598290]" /experiment="EXISTENCE:mutant phenotype:GO:0051382 kinetochore assembly [PMID:17452364]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245|PMID:10952318]" /note="Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes" /codon_start=1 /product="Arp4p" /protein_id="DAA08718.1" /db_xref="SGD:S000003617" /translation="MSNAALQVYGGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVY GKYTADEGNKKIFSEQSIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNS NSGIPALLTEPVWNSTENRKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDI GHDTCSVSPIVDGMTLSKSTRRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIK KTFDYEVDKSLYDYANNRGFFQECKETLCHICPTKTLEETKTELSSTAKRSIESPWNE EIVFDNETRYGFAEELFLPKEDDIPANWPRSNSGVVKTWRNDYVPLKRTKPSGVNKSD KKVTPTEEKEQEAVSKSTSPAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSS IMSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPSLKFRILTTGHTIERQY QSWLGGSILTSLGTFHQLWVGKKEYEEVGVERLLNDRFR" gene complement(285558..289226) /gene="SCP160" /locus_tag="YJL080C" mRNA complement(285558..289226) /gene="SCP160" /locus_tag="YJL080C" /product="Scp160p" CDS complement(285558..289226) /gene="SCP160" /locus_tag="YJL080C" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:11278502]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:22832273|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11278502]" /experiment="EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:8533468]" /experiment="EXISTENCE:genetic interaction:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:14536090]" /experiment="EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:16632467]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:8533468]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:16632467]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:16632467]" /experiment="EXISTENCE:mutant phenotype:GO:0043577 chemotropism [PMID:22832273]" /experiment="EXISTENCE:mutant phenotype:GO:0045141 meiotic telomere clustering [PMID:16632467]" /experiment="EXISTENCE:physical interaction:GO:0001965 G-protein alpha-subunit binding [PMID:14536090]" /note="Essential RNA-binding G protein effector of mating response pathway; ligand-activated RNA-binding protein that delivers RNAs involved in polarization and perpetualizing mating signal to shmoo tip during pheromone signaling; Scp160p-mediated RNA trafficking essential for chemotropism and successful mating; mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins" /codon_start=1 /product="Scp160p" /protein_id="DAA08719.1" /db_xref="SGD:S000003616" /translation="MSEEQTAIDSPPSTVEGSVETVTTIDSPSTTASTIAATAEEHPQ LEKKPTPLPSLKDLPSLGSNAAFANVKVSWGPNMKPAVSNSPSPSPSAPSLTTGLGAK RMRSKNIQEAFTLDLQSQLSITKPELSRIVQSVKKNHDVSVESTLSKNARTFLVSGVA ANVHEAKRELVKKLTKPINAVIEVPSKCKASIIGSGGRTIREISDAYEVKINVSKEVN ENSYDEDMDDTTSNVSLFGDFESVNLAKAKILAIVKEETKNATIKLVVEDEKYLPYID VSEFASDEGDEEVKVQFYKKSGDIVILGPREKAKATKTSIQDYLKKLASNLDEEKVKI PSKFQFLIDAEELKEKYNVIVTFPSTPDDELVSFVGLRDKVGEAITYARSSSKSYVVE SLDISKAHSKNLTHAKNLIMYFTKYSVLKGLEESHPNVKISLPSIQSLPTAETVTIHI SAKSDEANDIKAVRKELISFVNNIPPSETLVITDLDYELFGGSIKHCLLASESSVAFV QFGDYYPNDNSILLVALTEDEDFKPSIEEIQASLNKANESLNSLRTKQNNMETKTYEF SEEVQDSLFKPSSATWKLIMEDISEQEGHLQIKLHTPEENQLTVRGDEKAAKAANKIF ESILNSPSSKSKMTVNIPANSVARLIGNKGSNLQQIREKFACQIDIPNEENNNASKDK TVEVTLTGLEYNLTHAKKYLAAEAKKWADIITKELIVPVKFHGSLIGPHGTYRNRLQE KYNVFINFPRDNEIVTIRGPSRGVNKAHEELKALLDFEMENGHKMVINVPAEHVPRII GKNGDNINDIRAEYGVEMDFLQKSTDPKAQETGEVELEITGSRQNIKDAAKRVESIVA EASDFVTEVLKIDHKYHKSIVGSGGHILREIISKAGGEEIRNKSVDIPNADSENKDIT VQGPQKFVKKVVEEINKIVKDAENSVTKTIDIPAERKGALIGPGGIVRRQLESEFNIN LFVPNKDDPSGKITITGAPENVEKAEKKILNEIIRENFDREVDVPASIYEYVSERGAF IQKLRMDLSVNVRFGNTSKKANKLARAPIEIPLEKVCGSTEGENAEKTKFTIEEVGAP TSSEEGDITMRLTYEPIDLSSILSDGEEKEVTKDTSNDSAKKEEALDTAVKLIKERIA KAPSATYAGYVWGADTRRFNMIVGPGGSNIKKIREAADVIINVPRKSDKVNDVVYIRG TKAGVEKAGEMVLKSLRR" gene complement(289875..290774) /gene="PRY1" /locus_tag="YJL079C" mRNA complement(289875..290774) /gene="PRY1" /locus_tag="YJL079C" /product="sterol-binding protein" CDS complement(289875..290774) /gene="PRY1" /locus_tag="YJL079C" /experiment="EXISTENCE:direct assay:GO:0000287 magnesium ion binding [PMID:27344972]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005504 fatty acid binding [PMID:28365570]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:11935221]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0015485 cholesterol binding [PMID:27344972]" /experiment="EXISTENCE:direct assay:GO:0032934 sterol binding [PMID:23027975]" /experiment="EXISTENCE:genetic interaction:GO:0015908 fatty acid transport [PMID:28365570]" /experiment="EXISTENCE:genetic interaction:GO:0015918 sterol transport [PMID:23027975]" /experiment="EXISTENCE:mutant phenotype:GO:0005504 fatty acid binding [PMID:28365570]" /experiment="EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:23027975]" /experiment="EXISTENCE:mutant phenotype:GO:0032934 sterol binding [PMID:23027975]" /note="Lipid binding protein; binds to both free fatty acids with preference for saturated long-chain fatty acids and to sterols; contains two independent lipid-binding sites; involved in the export of free fatty acids and acetylated sterols; export functions are redundant with PRY2, and PRY3; important for survival of cells that accumulate free fatty acids; involved in detoxification of hydrophobic compounds; secreted glycoprotein and member of the CAP/SCP protein superfamily" /codon_start=1 /product="sterol-binding protein" /protein_id="DAA08720.1" /db_xref="SGD:S000003615" /translation="MKLSKLSILTSALATSALAAPAVVTVTEHAHEAAVVTVQGVVYV ENGQTRTTYETLAPASTATPTSTATALVAPPVAPSSASSNSDVVLSALKNLASVWGKT TDSTTTLTSSESTSQSLAQATTTSTPAAASTTSTPAATTTTSQAAATSSASSSDSDLS DFASSVLAEHNKKRALHKDTPALSWSDTLASYAQDYADNYDCSGTLTHSGGPYGENLA LGYDGPAAVDAWYNEISNYDFSNPGFSSNTGHFTQVVWKSTTQVGCGIKTCGGAWGDY VICSYDPAGNYEGEYADNVEPLA" gene complement(291336..293981) /gene="PRY3" /locus_tag="YJL078C" mRNA complement(291336..293981) /gene="PRY3" /locus_tag="YJL078C" /product="Pry3p" CDS complement(291336..293981) /gene="PRY3" /locus_tag="YJL078C" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:32554483|PMID:15781460|PMID:10383953]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015908 fatty acid transport [PMID:28365570]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:32554483]" /experiment="EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:23027975]" /note="GPI-anchored cell wall protein involved in export of sterols; redundant role with PRY1 and PRY2 in the export of free fatty acids; role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins)" /codon_start=1 /product="Pry3p" /protein_id="DAA08721.1" /db_xref="SGD:S000003614" /translation="MLEFPISVLLGCLVAVKAQTTFPNFESDVLNEHNKFRALHVDTA PLTWSDTLATYAQNYADQYDCSGVLTHSDGPYGENLALGYTDTGAVDAWYGEISKYNY SNPGFSESTGHFTQVVWKSTAEIGCGYKYCGTTWNNYIVCSYNPPGNYLGEFAEEVEP LISTVSSSSSSSSSTSTTSDTVSTISSSIMPAVAQGYTTTVSSAASSSSLKSTTINPA KTATLTASSSTVITSSTESVGSSTVSSASSSSVTTSYATSSSTVVSSDATSSTTTTSS VATSSSTTSSDPTSSTAAASSSDPASSSAAASSSASTENAASSSSAISSSSSMVSAPL SSTLTTSTASSRSVTSNSVNSVKFANTTVFSAQTTSSVSASLSSSVAADDIQGSTSKE ATSSVSEHTSIVTSATNAAQYATRLGSSSRSSSGAVSSSAVSQSVLNSVIAVNTDVSV TSVSSTAHTTKDTATTSVTASESITSETAQASSSTEKNISNSAATSSSIYSNSASVSG HGVTYAAEYAITSEQSSALATSVPATNCSSIVKTTTLENSSTTTITAITKSTTTLATT ANNSTRAATAVTIDPTLDPTDNSASPTDNAKHTSTYGSSSTGASLDSLRTTTSISVSS NTTQLVSTCTSESDYSDSPSFAISTATTTESNLITNTITASCSTDSNFPTSAASSTDE TAFTRTISTSCSTLNGASTQTSELTTSPMKTNTVVPASSFPSTTTTCLENDDTAFSSI YTEVNAATIINPGETSSLASDFATSEKPNEPTSVKSTSNEGTSSTTTTYQQTVATLYA KPSSTSLGARTTTGSNGRSTTSQQDGSAMHQPTSSIYTQLKEGTSTTAKLSAYEGAAT PLSIFQCNSLAGTIAAFVVAVLFAF" gene 294047..294145 /locus_tag="YJL077W-B" mRNA 294047..294145 /locus_tag="YJL077W-B" /product="hypothetical protein" CDS 294047..294145 /locus_tag="YJL077W-B" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08722.1" /db_xref="SGD:S000028662" /translation="MPILVWQLPKSKKLKTLKYRICFREFFDRVET" gene complement(294666..295061) /gene="ICS3" /locus_tag="YJL077C" mRNA complement(294666..295061) /gene="ICS3" /locus_tag="YJL077C" /product="Ics3p" CDS complement(294666..295061) /gene="ICS3" /locus_tag="YJL077C" /experiment="EXISTENCE:mutant phenotype:GO:0055070 copper ion homeostasis [PMID:26127016]" /note="Protein with a role in copper homeostasis; possible role in vacuolar sorting and processing of secretory proteins; null mutants are hypersensitive to sortin2" /codon_start=1 /product="Ics3p" /protein_id="DAA08723.1" /db_xref="SGD:S000003613" /translation="MHISLPTRNKSYFRIRTRTYQIGLYHSDSSPIRDISVLHLLIAT LCTIFFPIFFSLSKVQVVQWQGTTISKNCIALTMSFPLNAIPGMYLIIAFPRLQTVIP LQRNTPVRITKSVIVKGAVSVPRISSPMH" gene 294799..294885 /locus_tag="YJL077W-A" mRNA 294799..294885 /locus_tag="YJL077W-A" /product="hypothetical protein" CDS 294799..294885 /locus_tag="YJL077W-A" /note="hypothetical protein; mRNA identified as translated by ribosome profiling data; completely overlaps the verified gene YJL077C/ICS3" /codon_start=1 /product="hypothetical protein" /protein_id="DAA35120.1" /db_xref="SGD:S000028661" /translation="MPGIAFKGKDMVKAIQFLEIVVPCHCTT" gene 295245..298814 /gene="NET1" /locus_tag="YJL076W" /gene_synonym="CFI1" /gene_synonym="ESC5" /gene_synonym="SRM8" mRNA 295245..298814 /gene="NET1" /locus_tag="YJL076W" /gene_synonym="CFI1" /gene_synonym="ESC5" /gene_synonym="SRM8" /product="Net1p" CDS 295245..298814 /gene="NET1" /locus_tag="YJL076W" /gene_synonym="CFI1" /gene_synonym="ESC5" /gene_synonym="SRM8" /experiment="EXISTENCE:direct assay:GO:0000182 rDNA binding [PMID:10219245]" /experiment="EXISTENCE:direct assay:GO:0004864 protein phosphatase inhibitor activity [PMID:10219244]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10219244]" /experiment="EXISTENCE:direct assay:GO:0030869 RENT complex [PMID:10219244]" /experiment="EXISTENCE:direct assay:GO:1902570 protein localization to nucleolus [PMID:33481703]" /experiment="EXISTENCE:genetic interaction:GO:0001100 negative regulation of exit from mitosis [PMID:10219244]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:10219245]" /experiment="EXISTENCE:mutant phenotype:GO:0001100 negative regulation of exit from mitosis [PMID:26090959|PMID:10219244]" /experiment="EXISTENCE:mutant phenotype:GO:0007000 nucleolus organization [PMID:10219245]" /experiment="EXISTENCE:mutant phenotype:GO:1904751 positive regulation of protein localization to nucleolus [PMID:10219244]" /note="Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication" /codon_start=1 /product="Net1p" /protein_id="DAA08724.1" /db_xref="SGD:S000003612" /translation="MYKLQVVLVPPSLQATMPIQFGYGPTIAESSQLLPNRTNMAQSA GDASLQYANLRSANVSFTPSYFNQSRFRKFLLFTKPTNTLLNLSDEIIDKCEKMYPSL QEDIEILSLQDNSGCDLDPDFLVKDVFNVNNIVRVILKNEIDLDDSAPVSLYKSVKRS KLNNGSPQSVQPQQQIPSSSGVLRIAKKRPPTGTTTTTTIRSATNGSMRVSTPLARQI YPPPSSKIVSNNSDDEDEDIGERSFLPPPTQPQSPPIRISSGIDAGKKIKSSIVEEDI VSRSATVDPDKTKQQRLLSGTPIMSTMTPNRVTLTGQRVVSEHAHKNELVFSASASSS SFANGGTAAVTAQDINRKPPVTTPRITSGMLKIPEPRISEIEKELKEGPSSPASILPA KAAKIPMKKPYLENGENYESDDSSSSENQETPETEPHSKASLQRSQSSIADNNGSPVK NSPLGDAMPHNVHLAELPKASNTSITKSSNGESWGKQQEHQPPRKSSLETIVEKKSQA EPSGIVEPKRMTNFLDDNQVREKEDTNDKLLEKEILPTIPHNDQPILASSDKSNGTLK SLAGKVSSNNNASKEDGTIINGTIEDDGNDNDEVDTTVRIVPQDSDSSSFPKSDLFKM IEGDDTDLPQWFKGKNSRTSGNSKNSKPYTTVLNKDIDNSKPDPRNILPQRTPRSAAK RAAQLLAGAKKNEVPQKSTEDSSSAASTDDESESGIETDFSSDDDFKRKNMSVPNNGP KDISLHSLKGSVVPVKDSKIINKEVDEERNDKRDSQKKSAVSESSVTNSKISEQMAKS FYPNSNKKQNEATKVETKPATQASSFPVVGGSPSVATKGTTSFNEEGNRKNVKTKAKN ESAQIDRQQKETTSRVADLKSANIGGEDLNKKAEGSKEPEKASANIQDANDKNNSKEK EDSKSKQVSQKKLKMTDHLKEGNVQLPKPSANDKLKDLKAKFTNSKTLVPPGIISNEK NNSSANDDDSSSSGSSTEDESSSSSSSSDEETSTSRKARRVVVNTPREPVRSSSKIEA PSPSVNKKINATPDKIPVTQLMDMSSPPSVKSKTTSNPSSILHDLPRKVRPSLSSLSD LVSRGIPDVKEKTSKSNEKSQTKAPSSSDDESSSDSDSNSSSDSVSDSSSDSKSESDS DDSGDSSDDGKSFISAKSASAALGKKKKPSGGFASLIKDFKKK" gene complement(298460..298876) /gene="APQ13" /locus_tag="YJL075C" mRNA complement(298460..298876) /gene="APQ13" /locus_tag="YJL075C" /product="Apq13p" CDS complement(298460..298876) /gene="APQ13" /locus_tag="YJL075C" /note="hypothetical protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps verified gene NET1, but does not share all phenotypes; null mutant is slow-growing, sensitive to heat, sorbate, and other various chemicals" /codon_start=1 /product="Apq13p" /protein_id="DAD54806.1" /db_xref="SGD:S000003611" /translation="MLDYFFLLAFCDVYSTETFWYHFFLKSFINDANPPLGFFFLPKA ALADFALIKLFPSSDESPESSESDSDLESELESDTESELELESESELDSSSLLEGAFV CDFSFDLEVFSFTSGMPLETRSDNELKEGRTFLGRS" rep_origin 298981..299245 /note="ARS1010; Autonomously Replicating Sequence" /db_xref="SGD:S000028447" gene complement(299157..302849) /gene="SMC3" /locus_tag="YJL074C" mRNA complement(299157..302849) /gene="SMC3" /locus_tag="YJL074C" /product="cohesin subunit SMC3" CDS complement(299157..302849) /gene="SMC3" /locus_tag="YJL074C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:17055978]" /experiment="EXISTENCE:direct assay:GO:0030892 mitotic cohesin complex [PMID:9990856]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:9335333]" /experiment="EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:10412984]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10412984]" /experiment="EXISTENCE:mutant phenotype:GO:0051177 meiotic sister chromatid cohesion [PMID:10412984]" /experiment="EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:16888651]" /experiment="EXISTENCE:physical interaction:GO:0000086 G2/M transition of mitotic cell cycle [PMID:27325700]" /experiment="EXISTENCE:physical interaction:GO:0019901 protein kinase binding [PMID:27325700]" /note="Subunit of the multiprotein cohesin complex; required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member" /codon_start=1 /product="cohesin subunit SMC3" /protein_id="DAA08725.1" /db_xref="SGD:S000003610" /translation="MYIKRVIIKGFKTYRNETIIDNFSPHQNVIIGSNGSGKSNFFAA IRFVLSDDYSNLKREERQGLIHQGSGGSVMSASVEIVFHDPDHSMILPSGVLSRGDDE VTIRRTVGLKKDDYQLNDRNVTKGDIVRMLETAGFSMNNPYNIVPQGKIVALTNAKDK ERLQLLEDVVGAKSFEVKLKASLKKMEETEQKKIQINKEMGELNSKLSEMEQERKELE KYNELERNRKIYQFTLYDRELNEVINQMERLDGDYNNTVYSSEQYIQELDKREDMIDQ VSKKLSSIEASLKIKNATDLQQAKLRESEISQKLTNVNVKIKDVQQQIESNEEQRNLD SATLKEIKSIIEQRKQKLSKILPRYQELTKEEAMYKLQLASLQQKQRDLILKKGEYAR FKSKDERDTWIHSEIEELKSSIQNLNELESQLQMDRTSLRKQYSAIDEEIEELIDSIN GPDTKGQLEDFDSELIHLKQKLSESLDTRKELWRKEQKLQTVLETLLSDVNQNQRNVN ETMSRSLANGIINVKEITEKLKISPESVFGTLGELIKVNDKYKTCAEVIGGNSLFHIV VDTEETATLIMNELYRMKGGRVTFIPLNRLSLDSDVKFPSNTTTQIQFTPLIKKIKYE PRFEKAVKHVFGKTIVVKDLGQGLKLAKKHKLNAITLDGDRADKRGVLTGGYLDQHKR TRLESLKNLNESRSQHKKILEELDFVRNELNDIDTKIDQVNGNIRKVSNDRESVLTNI EVYRTSLNTKKNEKLILEESLNAIILKLEKLNTNRTFAQEKLNTFENDLLQEFDSELS KEEKERLESLTKEISAAHNKLNITSDALEGITTTIDSLNAELESKLIPQENDLESKMS EVGDAFIFGLQDELKELQLEKESVEKQHENAVLELGTVQREIESLIAEETNNKKLLEK ANNQQRLLLKKLDNFQKSVEKTMIKKTTLVTRREELQQRIREIGLLPEDALVNDFSDI TSDQLLQRLNDMNTEISGLKNVNKRAFENFKKFNERRKDLAERASELDESKDSIQDLI VKLKQQKVNAVDSTFQKVSENFEAVFERLVPRGTAKLIIHRKNDNANDHDESIDVDMD AESNESQNGKDSEIMYTGVSISVSFNSKQNEQLHVEQLSGGQKTVCAIALILAIQMVD PASFYLFDEIDAALDKQYRTAVATLLKELSKNAQFICTTFRTDMLQVADKFFRVKYEN KISTVIEVNREEAIGFIRGSNKFAEV" gene 303181..305118 /gene="JEM1" /locus_tag="YJL073W" /gene_synonym="KAR8" mRNA 303181..305118 /gene="JEM1" /locus_tag="YJL073W" /gene_synonym="KAR8" /product="Jem1p" CDS 303181..305118 /gene="JEM1" /locus_tag="YJL073W" /gene_synonym="KAR8" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:9148890]" /experiment="EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:15282802]" /experiment="EXISTENCE:genetic interaction:GO:0034975 protein folding in endoplasmic reticulum [PMID:9817751]" /experiment="EXISTENCE:genetic interaction:GO:0051087 protein-folding chaperone binding [PMID:9148890]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:10069807]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:11381090]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:9148890]" /note="DnaJ-like chaperone required for nuclear membrane fusion during mating; localizes to the ER membrane; exhibits genetic interactions with KAR2" /codon_start=1 /product="Jem1p" /protein_id="DAA08726.1" /db_xref="SGD:S000003609" /translation="MILISGYCLLVYSVILPVLISASKLCDLAELQRLNKNLKVDTES LPKYQWIAGQLEQNCMTADPASENMSDVIQLANQIYYKIGLIQLSNDQHLRAINTFEK IVFNETYKGSFGKLAEKRLQELYVDFGMWDKVHQKDDQYAKYLSLNETIRNKISSKDV SVEEDISELLRITPYDVNVLSTHIDVLFHKLAEEIDVSLAAAIILDYETILDKHLASL SIDTRLSIHYVISVLQTFVLNSDASFNIRKCLSIDMDYDKCKKLSLTISKLNKVNPSK RQILDPATYAFENKKFRSWDRIIEFYLKDKKPFITPMKILNKDTNFKNNYFFLEEIIK QLIEDVQLSRPLAKNLFEDPPITDGFVKPKSYYHTDYLVYIDSILCQASSMSPDVKRA KLAAPFCKKSLRHSLTLETWKHYQDAKSEQKPLPETVLSDVWNSNPHLLMYMVNSILN KSRSKPHSQFKKQLYDQINKFFQDNGLSESTNPYVMKNFRLLQKQLQTYKEHKHRNFN QQYFQQQQQQQQHQRHQAPPAAPNYDPKKDYYKILGVSPSASSKEIRKAYLNLTKKYH PDKIKANHNDKQESIHETMSQINEAYETLSDDDKRKEYDLSRSNPRRNTFPQGPRQNN MFKNPGSGFPFGNGFKMNFGL" gene complement(305221..305862) /gene="PSF2" /locus_tag="YJL072C" /gene_synonym="CDC102" mRNA complement(305221..305862) /gene="PSF2" /locus_tag="YJL072C" /gene_synonym="CDC102" /product="DNA replication protein PSF2" CDS complement(305221..305862) /gene="PSF2" /locus_tag="YJL072C" /gene_synonym="CDC102" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:16531994]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:16103218]" /experiment="EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]" /experiment="EXISTENCE:genetic interaction:GO:0006261 DNA-templated DNA replication [PMID:12730134]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:12768207]" /experiment="EXISTENCE:physical interaction:GO:0000811 GINS complex [PMID:12768207|PMID:12730134]" /experiment="EXISTENCE:physical interaction:GO:0031261 DNA replication preinitiation complex [PMID:12730134]" /note="Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery" /codon_start=1 /product="DNA replication protein PSF2" /protein_id="DAA08727.1" /db_xref="SGD:S000003608" /translation="MSLPAHLQQTFSPEEIQFIVENEPIKIFPRITTRQKIRGDDRGT GNHTRWQLITTDDKALNNMVAMRSTEVVLWIALLLKQQSKCSIVAPQWLTTKELDRKI QYEKTHPDRFSELPWNWLVLARILFNKAKDDFHDPIHELRGKIQDLREIRQIKVLKGL KYLNESHLQLDNLSLLEINELRPFITEIMDKLREIHTASLTAGTENDEEEFNI" gene 306132..307856 /gene="ARG2" /locus_tag="YJL071W" /gene_synonym="HRB574" mRNA 306132..307856 /gene="ARG2" /locus_tag="YJL071W" /gene_synonym="HRB574" /product="acetyl-CoA:L-glutamate N-acetyltransferase" CDS 306132..307856 /gene="ARG2" /locus_tag="YJL071W" /gene_synonym="HRB574" /EC_number="2.3.1.1" /experiment="EXISTENCE:direct assay:GO:0004042 L-glutamate N-acetyltransferase activity [PMID:11553611]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:205532]" /experiment="EXISTENCE:mutant phenotype:GO:0004042 L-glutamate N-acetyltransferase activity [PMID:11553611]" /experiment="EXISTENCE:mutant phenotype:GO:0006592 ornithine biosynthetic process [PMID:11553611]" /note="Acetylglutamate synthase (glutamate N-acetyltransferase); mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p" /codon_start=1 /product="acetyl-CoA:L-glutamate N-acetyltransferase" /protein_id="DAA08728.1" /db_xref="SGD:S000003607" /translation="MWRRIFAHELKYDQPNASSKNLILSVLNTTATKREAKDYLSKYT NDSGQHNHCLFFIRDLHKVAPAILSQFSSVIKRLGMLGLRPMFVIPPSPTHVNIQAEL LDSIVTEADLKPLHLKEGLTKSRTGLYHSVFSQESRFFDIGNSNFIPIVKPYVYNEET ASEFMTKDVVKFMDCLCQGNIPHIDKFFILNNAGGIPSGERNDNAHVFINLSQELEHL SSSLSHNISTLTKREPRSQNLLHRMEVYVKKDEISSLECEYHDHLENLLLMDKVLSNL AATATGLITTVKAAALSSDRKNPLVYNLLTDRSLISSSLPRFKKKDGEIDSPANMFDD HAWYELPSQQVNAAPSNSDAVLVTTVLKKGVHIKTYDYKTLTQFNSIGLPKKFHVPEK GAKPSSNSPKLDINKFKSIIDQSFKRSLDLHDYIKRINGKIATIIVIGDYEGIAILTY EGSEENSFVYLDKFAVLPHLKGSLGISDIIFNLMFKKFPNEILWRSRKDNVVNKWYFQ RSVAVLDLSIDLDPEHCDEKQSQFKLFYYGNPQYAKRALRDKKRLREFMRSVRDIKPS WENEKNIS" gene complement(307971..310637) /locus_tag="YJL070C" mRNA complement(307971..310637) /locus_tag="YJL070C" /product="metallo-dependent hydrolase superfamily protein" CDS complement(307971..310637) /locus_tag="YJL070C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /note="Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication" /codon_start=1 /product="metallo-dependent hydrolase superfamily protein" /protein_id="DAA08729.1" /db_xref="SGD:S000003606" /translation="MQAVERRPSLLFDEYQNSVTKPNETKNKEARVLSENDGDVSPSV LKQKEISVDDMDMISLPTEFDRQMVLGSPMFFDLEDEENKIDPLPSVSHHYGNGESDS FVSSYTPSNLKTGEETKDLFINPFELVSQMRKRYIAASKQDGISNIKNDTEKWFLYPK PLPKFWRFEDDKRFQDPSDSDLNDDGDSTGTGAATPHRHGYYYPSYFTDHYYYYTKSG LKGKGNIKVPYTGEYFDLEDYKKQYIYHLSNQENTQNPLSPYSSKEESLEEEFLTDVP TFQEFRDDFAYIIELIQSHKFNEVSRKRLSYLLDKFELFQYLNSKKEILANKNVPYRD FYNSRKVDRDLSLSGCISQRQLSEYIWEKINLEPERIVYQDPETSRKLSLRDIFQFGC SSNDQPIAIGLKLIDDEFLDWYRNIYLIDYHLTPNKVAKLVGKEMRFYLLAKVFLEFD NFIEGEYLAEIFIKYVIHILEKSKYQLAQVSVNFQFYSSGEDWYKKFSQWLLRWKLVS YNIRWNIQIARIFPKLFKENVVSNFQEFLDLIFNPLFTLEKEQLPIDSSVNTDIIGLQ FFLSNVCSMDLVIKESDEYYWKEFTDMNCKPKFWTAQGDNPTVAHYMYYIYKSLAKVN FLRSQNLQNTITLRNYCSPLSSRTSQFGVDLYFTDQVESLVCNLLLCNGGLLQVEPLW DTATMIQYLFYLFQIPILAAPLSSVSLLNSQKSTFLKNKNVLLEHDYLKDQETAKINP SRDITVGEQRSYETNPFMKMFKMGLKISLSSKSILYNSSYTLEPLIEEYSVAASIYLL NPTDLCELSRTSVLSSGYEGWYKAHWIGVGVKKAPYFEENVGGIDNWYDTAKDTSIKH NVPMIRRRYRKETLDQEWNFVRDHFGVINSIW" gene complement(310922..312706) /gene="UTP18" /locus_tag="YJL069C" mRNA complement(310922..312706) /gene="UTP18" /locus_tag="YJL069C" /product="Utp18p" CDS complement(310922..312706) /gene="UTP18" /locus_tag="YJL069C" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15590835|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:direct assay:GO:0034388 Pwp2p-containing subcomplex of 90S preribosome [PMID:15231838|PMID:17515605]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]" /note="Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; contains WD40 repeats" /codon_start=1 /product="Utp18p" /protein_id="DAA08730.1" /db_xref="SGD:S000003605" /translation="MTMATTAMNVSVPPPDEEEQLLAKFVFGDTTDLQENLAKFNADF IFNEQEMDVEDQEDEGSESDNSEEDEAQNGELDHVNNDQLFFVDDGGNEDSQDKNEDT MDVDDEDDSSSDDYSEDSEEAAWIDSDDEKIKVPILVTNKTKKLRTSYNESKINGVHY INRLRSQFEKIYPRPKWVDDESDSELDDEEDDEEEGSNNVINGDINALTKILSTTYNY KDTLSNSKLLPPKKLDIVRLKDANASHPSHSAIQSLSFHPSKPLLLTGGYDKTLRIYH IDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHS QTAKIEKFSRLYGHESTQRSFENFKVAHLQNSQTNSVHGIVLLQGNNGWINILHSTSG LWLMGCKIEGVITDFCIDYQPISRGKFRTILIAVNAYGEVWEFDLNKNGHVIRRWKDQ GGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPV AALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGKVT SVAFSPSGGLLAVGNEQGKVRLWKLNHY" gene complement(313016..313915) /locus_tag="YJL068C" mRNA complement(313016..313915) /locus_tag="YJL068C" /product="S-formylglutathione hydrolase" CDS complement(313016..313915) /locus_tag="YJL068C" /EC_number="3.1.2.12" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10427036]" /experiment="EXISTENCE:direct assay:GO:0018738 S-formylglutathione hydrolase activity [PMID:10427036]" /experiment="EXISTENCE:mutant phenotype:GO:0046294 formaldehyde catabolic process [PMID:10427036]" /note="Esterase that can function as an S-formylglutathione hydrolase; non-essential intracellular esterase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D" /codon_start=1 /product="S-formylglutathione hydrolase" /protein_id="DAA08731.1" /db_xref="SGD:S000003604" /translation="MKVVKEFSVCGGRLIKLSHNSNSTKTSMNVNIYLPKHYYAQDFP RNKRIPTVFYLSGLTCTPDNASEKAFWQFQADKYGFAIVFPDTSPRGDEVANDPEGSW DFGQGAGFYLNATQEPYAQHYQMYDYIHKELPQTLDSHFNKNGDVKLDFLDNVAITGH SMGGYGAICGYLKGYSGKRYKSCSAFAPIVNPSNVPWGQKAFKGYLGEEKAQWEAYDP CLLIKNIRHVGDDRILIHVGDSDPFLEEHLKPELLLEAVKATSWQDYVEIKKVHGFDH SYYFVSTFVPEHAEFHARNLGLI" gene complement(314114..314872) /gene="MPM1" /locus_tag="YJL066C" mRNA complement(314114..314872) /gene="MPM1" /locus_tag="YJL066C" /product="Mpm1p" CDS complement(314114..314872) /gene="MPM1" /locus_tag="YJL066C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:9874242|PM ID:11791739]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289|PMID:22993211]" /note="Mitochondrial intermembrane space hypothetical protein" /codon_start=1 /product="Mpm1p" /protein_id="DAA08732.1" /db_xref="SGD:S000003602" /translation="MGFYEGDDNDANTKAFNDKYIKDQKFATAPFWNLFPKLRDIDEY DNPLLPLPFNFNFRDLGDSALAMASGIPTVKQFDKCEELKGQSAWTTQGIWKCLVPSK AIPPLPQLDFLLPLEEIKSDKSHSHGLFFNDFNLFLKWRSHMNRLQKQRIKTRSTAVE PLARTPEDLMLNWDDLHLGNDAEYASADGSKKIVGRAQSISTTKDSNDAKPSTVKTEK IYFDDGTVDITTTTTSKGSSPQVKHKVVSVDEDN" gene complement(315054..315557) /gene="DLS1" /locus_tag="YJL065C" mRNA complement(315054..315557) /gene="DLS1" /locus_tag="YJL065C" /product="Dls1p" CDS complement(315054..315557) /gene="DLS1" /locus_tag="YJL065C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008623 CHRAC [PMID:15024052]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:14673157]" /experiment="EXISTENCE:mutant phenotype:GO:1903775 regulation of DNA double-strand break processing [PMID:34362907]" /note="Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication" /codon_start=1 /product="Dls1p" /protein_id="DAA08733.1" /db_xref="SGD:S000003601" /translation="MNNETSGKETASAPLCSPKLPVEKVQRIAKNDPEYMDTSDDAFV ATAFATEFFVQVLTHESLHRQQQQQQQQVPPLPDELTLSYDDISAAIVHSSDGHLQFL NDVIPTTKNLRLLVEENRVRYTTSVMPPNEVYSAYVVNDTAPKPNIVEIDLDNDEDDD EDVTDQE" gene complement(315759..316475) /gene="MRPL8" /locus_tag="YJL063C" /gene_synonym="bL17m" /gene_synonym="HRD238" mRNA complement(315759..316475) /gene="MRPL8" /locus_tag="YJL063C" /gene_synonym="bL17m" /gene_synonym="HRD238" /product="mitochondrial 54S ribosomal protein YmL8" CDS complement(315759..316475) /gene="MRPL8" /locus_tag="YJL063C" /gene_synonym="bL17m" /gene_synonym="HRD238" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit" /codon_start=1 /product="mitochondrial 54S ribosomal protein YmL8" /protein_id="DAA08734.1" /db_xref="SGD:S000003599" /translation="MTVGIARKLSRDKAHRDALLKNLACQLFQHESIVSTHAKCKEAS RVAERIITWTKRAITTSNSVAQAELKSQIQSQLFLAGDNRKLMKRLFSEIAPRYLERP GGYTRVLRLEPRANDSAPQSVLELVDSPVMSESHTVNRGNLKMWLLVKSVINDDANQL PHNPLTLQNLHKVAKFKAEAQLHGEIMLIKQVLLKEMSLPYDEALENERTQALLKEVY SSSLPKKTKKPSSYVMVPRP" gene 316723..316980 /gene="COA3" /locus_tag="YJL062W-A" /gene_synonym="COX25" /gene_synonym="RRG10" mRNA 316723..316980 /gene="COA3" /locus_tag="YJL062W-A" /gene_synonym="COX25" /gene_synonym="RRG10" /product="Coa3p" CDS 316723..316980 /gene="COA3" /locus_tag="YJL062W-A" /gene_synonym="COX25" /gene_synonym="RRG10" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:21068384|PMID:20876281]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:21068384|PMID:20876281]" /experiment="EXISTENCE:mutant phenotype:GO:0070130 negative regulation of mitochondrial translation [PMID:21068384|PMID:20876281]" /note="Mitochondrial protein required for cytochrome c oxidase assembly; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; located in the mitochondrial inner membrane" /codon_start=1 /product="Coa3p" /protein_id="DAA08735.1" /db_xref="SGD:S000007611" /translation="MVLNPSKYQDTRTWKMTPAMIRARKPFFKGNMLGLTLLLGVTGS VYYYTYHFLHKDNDFADVPIPPIDPQELEALKKEYEAKKKA" gene 317284..319776 /gene="LAS21" /locus_tag="YJL062W" /gene_synonym="GPI7" mRNA 317284..319776 /gene="LAS21" /locus_tag="YJL062W" /gene_synonym="GPI7" /product="mannose-ethanolamine phosphotransferase LAS21" CDS 317284..319776 /gene="LAS21" /locus_tag="YJL062W" /gene_synonym="GPI7" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:10329735]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10329735]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:15452134|PMID:10329735]" /experiment="EXISTENCE:mutant phenotype:GO:0051267 CP2 mannose-ethanolamine phosphotransferase activity [PMID:15452134|PMID:10329735]" /note="Mannose-ethanolamine phosphotransferase; involved in biosynthesis of the glycosylphosphatidylinositol (GPI) core structure, catalyzing the addition of a side chain ethanolamine phosphate to the alpha1,6-linked second mannose residue of the GPI lipid precursor; integral component of endoplasmic reticulum membrane; mutations affect cell wall integrity; homolog of human PIGG" /codon_start=1 /product="mannose-ethanolamine phosphotransferase LAS21" /protein_id="DAA08736.1" /db_xref="SGD:S000003598" /translation="MNLKQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRD LQRDRPFQKLVFVIIDALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANPPTVTLP RLKSITTGSTPSFIDLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLF PQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKD GPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGET SAGLLFLSPKLAQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPI PMNSVGIIIPDFLQLLPNKLASMKENFMHLWKLSDHHGEVALDDFTAEDIYTKMYTIQ ETLTKSATNYNYPLLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIIL GVSTFASSFIEEEHQLWWWIVTAFSAVPLFVYRLNVLIIVRWFIMMACVRSIKFWNNS GQKFIYSNVMSNLLNQNPSWKWCLNMLTFLVLIMASAGFQVLHFIVTTILVGLCFTYK ISWEIVNGNQAEIPLFMHDLLAKIDFAPTESNLIVLARVFFQAWAIVVISRLVLTKLK VLNKNYLIKDMKVYITILLMFQTSSQNIGQFLVFQILESQIFYFFQNIPTASLTSTSK IYFSNLVSLILQNFTFFQFGGTNSISTIDLGNAYHGVSSDYNIYVVGILMSVANFAPA IYWSMLPWSINYASIPAQVKLQTFIRSKLPAFTYHCIFGTCLMTACVVLRFHLFIWSV FSPKLCYFLGWNFVMGLLNGWLPELALLCALD" gene 320016..322157 /gene="NUP82" /locus_tag="YJL061W" /gene_synonym="HRB187" mRNA 320016..322157 /gene="NUP82" /locus_tag="YJL061W" /gene_synonym="HRB187" /product="linker nucleoporin NUP82" CDS 320016..322157 /gene="NUP82" /locus_tag="YJL061W" /gene_synonym="HRB187" /experiment="EXISTENCE:curator inference:GO:0017056 structural constituent of nuclear pore [PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:7559751]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0044612 nuclear pore linkers [PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0044614 nuclear pore cytoplasmic filaments [PMID:9736720|PMID:10684247]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11739405|PMID:11071906]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:11739405|PMID:10465789]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:7559750|PMID:7559751]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:15294903]" /experiment="EXISTENCE:mutant phenotype:GO:0006611 protein export from nucleus [PMID:17347149|PMID:15294903]" /note="Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p); relocalizes to the cytosol in response to hypoxia" /codon_start=1 /product="linker nucleoporin NUP82" /protein_id="DAA08737.1" /db_xref="SGD:S000003597" /translation="MSQSSRLSALPIFQASLSASQSPRYIFSSQNGTRIVFIQDNIIR WYNVLTDSLYHSLNFSRHLVLDDTFHVISSTSGDLLCLFNDNEIFVMEVPWGYSNVED VSIQDAFQIFHYSIDEEEVGPKSSIKKVLFHPKSYRDSCIVVLKEDDTITMFDILNSQ EKPIVLNKPNNSFGLDARVNDITDLEFSKDGLTLYCLNTTEGGDIFAFYPFLPSVLLL NEKDLNLILNKSLVMYESLDSTTDVIVKRNVIKQLQFVSKLHENWNSRFGKVDIQKEY RLAKVQGPFTINPFPGELYDYTATNIATILIDNGQNEIVCVSFDDGSLILLFKDLEMS MSWDVDNYVYNNSLVLIERVKLQREIKSLITLPEQLGKLYVISDNIIQQVNFMSWAST LSKCINESDLNPLAGLKFESKLEDIATIERIPNLAYINWNDQSNLALMSNKTLTFQNI SSDMKPQSTAAETSISTEKSDTVGDGFKMSFTQPINEILILNDNFQKACISPCERIIP SADRQIPLKNEASENQLEIFTDISKEFLQRIVKAQTLGVSIHNRIHEQQFELTRQLQS TCKIISKDDDLRRKFEAQNKKWDAQLSRQSELMERFSKLSKKLSQIAESNKFKEKKIS HGEMKWFKEIRNQILQFNSFVHSQKSLQQDLSYLKSELTRIEAETIKVDKKSQNEWDE LRKMLEIDSKIIKECNEELLQVSQEFTTKTQ" gene 323386..324720 /gene="BNA3" /locus_tag="YJL060W" mRNA 323386..324720 /gene="BNA3" /locus_tag="YJL060W" /product="kynurenine--oxoglutarate transaminase" CDS 323386..324720 /gene="BNA3" /locus_tag="YJL060W" /EC_number="2.6.1.7" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:17034789]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17034789|PMID:14562095|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0016212 kynurenine-oxoglutarate transaminase activity [PMID:18205391]" /experiment="EXISTENCE:direct assay:GO:0034276 kynurenic acid biosynthetic process [PMID:18205391]" /experiment="EXISTENCE:direct assay:GO:0047536 2-aminoadipate transaminase activity [PMID:19342587]" /note="Kynurenine aminotransferase; catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate" /codon_start=1 /product="kynurenine--oxoglutarate transaminase" /protein_id="DAA08738.1" /db_xref="SGD:S000003596" /translation="MKQRFIRQFTNLMSTSRPKVVANKYFTSNTAKDVWSLTNEAAAK AANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLI KLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCG GKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTRE ELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAAT GWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYI NKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWL INELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDYL" gene 324964..326190 /gene="YHC3" /locus_tag="YJL059W" /gene_synonym="BTN1" mRNA 324964..326190 /gene="YHC3" /locus_tag="YJL059W" /gene_synonym="BTN1" /product="amino acid transporter YHC3" CDS 324964..326190 /gene="YHC3" /locus_tag="YJL059W" /gene_synonym="BTN1" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:9753630|PMID:10319861]" /experiment="EXISTENCE:mutant phenotype:GO:0015819 lysine transport [PMID:14660799]" /experiment="EXISTENCE:mutant phenotype:GO:0051453 regulation of intracellular pH [PMID:10319861|PMID:10191121|PMID:16423829]" /experiment="EXISTENCE:mutant phenotype:GO:1903826 L-arginine transmembrane transport [PMID:14660799]" /note="Protein required for the ATP-dependent transport of arginine; vacuolar membrane protein; involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; human homolog CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) can complement yeast null mutant" /codon_start=1 /product="amino acid transporter YHC3" /protein_id="DAA08739.1" /db_xref="SGD:S000003595" /translation="MSDKSHQIYCYFWLFGLINNVLYVVILSAAVDIVGPTLPKSLVL LADIFPSLAIKLCSPFFIDRIKYSYRIWSLITMSCLGMFLVSFKNLFVCLLGISFASI SSGFGEVTFLQLTHYYKQISLNGWSSGTGGAGIIGGASYMFLTSIFKVPVKLTLLVFS LLPFAFLFYFKLESNDTNLTYQSLQQIDEAEDDQLVPFPVAFTHTNASQSLYSTRQHI LQTVKRLRRLVFPYMVPLTTVYLFEYLINQAVAPTLLFPINGDERSKSMPFFFHKYRD IYVTYGTLYQLGVFISRSFGHLMRMRSLYILAFLQGVNLCITVLQSWFYVTHSPWAVM ILIFYEGFLGGASYVNTFLNILEQEDPDETEFAMGAVSIADSFGVFLAALLGLGLEPK LCRHQIADDRPWCRME" gene complement(326242..327873) /gene="BIT61" /locus_tag="YJL058C" mRNA complement(326242..327873) /gene="BIT61" /locus_tag="YJL058C" /product="Bit61p" CDS complement(326242..327873) /gene="BIT61" /locus_tag="YJL058C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19144819]" /experiment="EXISTENCE:direct assay:GO:0031932 TORC2 complex [PMID:14736892]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:14736892]" /experiment="EXISTENCE:physical interaction:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:14736892]" /experiment="EXISTENCE:physical interaction:GO:0031505 fungal-type cell wall organization [PMID:14736892]" /note="Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; PM retention is dependent on Avo3p; BIT61 has a paralog, BIT2, that arose from the whole genome duplication" /codon_start=1 /product="Bit61p" /protein_id="DAA08740.1" /db_xref="SGD:S000003594" /translation="MTAEDILLRERTSTTTQRPVNSEQYLNVQLATAPVKNFQTTSEI SRQTLVDTSNDDVYSIKNLKGSRNPISPSVSNVGFQSIFHTVDHPRSKVSVASNHSLR SNDNASAATSKSGSSQIGESHSVDTVECSNNLSKKLSSDAISITQKSLHSTPSGRYMK GKASGFFNRRNRAHTTISSDPASFLTDSSTLHNSSHSFRNVIKNFFQNKSHRHIGQDA IEPAIPNSLSKFLHSSYGRHKSPSQFIHTNAGQLVDSGTSVYSLNVNPSGVNPNTIVE DPLSGTDPASPNPVSMLHDLLRNLPSLEANYKHFNSQELTTLTNNIWNIFCSNVAELF RTQRIWKLRAKIENFNEVLEFYCILKTDPRVTHSGMNRIISDLKEFLVSSLYNLENQI VFNYSNEDTINNALKRLGVIWRIFYQEVYYDLAAVLLPLDQSIREDGNSTVLKSGNES RTHINGNYSIGFLLLMCFRDSIVLPCYENFVNSNDGISKSFQLYIFNQEEESNVTETD KLTLLQCFGILSTIQSNDRNQRIIEELLAGIRMSI" gene complement(328118..330121) /gene="IKS1" /locus_tag="YJL057C" mRNA complement(328118..330121) /gene="IKS1" /locus_tag="YJL057C" /product="protein kinase IKS1" CDS complement(328118..330121) /gene="IKS1" /locus_tag="YJL057C" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0006468 protein phosphorylation [PMID:16319894]" /note="Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p" /codon_start=1 /product="protein kinase IKS1" /protein_id="DAA08741.1" /db_xref="SGD:S000003593" /translation="MSLVPYEEGSLILDDPNSKSVVVVNPTSGTLSFFQQDNSNNDSE LNEDQTASLSALDFPSGIHQYKSPIASYVCPQCGTEINPDIINRRQLHRRASAGVESE SSRLSIPENTVPLGFEFANSSFSRRYFQSLERNHRHYALQNDSNNKQGQFSKNKYFIP DDLFIPGYFRKFFKILSLLGNGARGSVYKVVHTIGNTELGVFALKKIPIGNDMEWFNK CIREVKALSSLTHKSANLITYNHVWLEMDSSVGFVRSIDGSQSDSQEEVPCIFILQQY CSGGNLEDCILRKVFNRFSDTESPEERKKKFRTRKKNHGKSGEVGLSTEQLVSIIRDI ARGLHELHSIGLIHRDLKPSNCLLLTPFKSDNENDNVYDREHNSDEFFPSIVIGDLGE SQLEGESRLGTGCTGTLEFTAPDLIIQGRPVSSSTLPSRSSHTYNEYTFASDMYSLGM ICYFIVFGELPFEPQLDIVDLKVRIKNFRFDTEGMIEKHQAMKLKPIDRRIFHLMDAL LQPNNDARPTAKTVEETLDEMLINSKPGKKFWKENVDSTLNFSTISEVNENTNSFTDD YIDGDNVTLSLPAPEENLSTVSTQNLQKYSALNRTIQVCYKLVSMILTIIIFKCTKTG SWLSYMSLILLGMVFKSPADERGKHARALVLLAFIAACKKYIY" gene complement(330431..333073) /gene="ZAP1" /locus_tag="YJL056C" /gene_synonym="ZRG10" mRNA complement(330431..333073) /gene="ZAP1" /locus_tag="YJL056C" /gene_synonym="ZRG10" /product="Zap1p" CDS complement(330431..333073) /gene="ZAP1" /locus_tag="YJL056C" /gene_synonym="ZRG10" /experiment="EXISTENCE:direct assay:GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding [PMID:9786867]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:22128164]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10899124]" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:16720702|PMID:14517251]" /experiment="EXISTENCE:direct assay:GO:0034224 cellular response to zinc ion starvation [PMID:22128164]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:22128164]" /experiment="EXISTENCE:mutant phenotype:GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding [PMID:9786867|PMID:12549926]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9786867|PMID:9271382]" /experiment="EXISTENCE:mutant phenotype:GO:0008270 zinc ion binding [PMID:16720702]" /experiment="EXISTENCE:mutant phenotype:GO:0034224 cellular response to zinc ion starvation [PMID:9271382|PMID:12095998|PMID:9786867]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12095998]" /note="Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains" /codon_start=1 /product="Zap1p" /protein_id="DAA08742.1" /db_xref="SGD:S000003592" /translation="MDALTPRDSPKRDDSMATSAATAASAKPDALTIGKEGIVHGHIH NYNNLTYIHGHLHHSAPVNDSSASATPAAAAVADAATSAFASGASHDMGGDCHVNEKC KEYTDCQHFEFLNYHNNPSLTKYNDTATYNSNNHSFANNFHSVASDPTSPQQNSKSDL PRRKDSWFNDDLILLPSSKKNKPNPPPGSDDCYCTPKILEICCDETHPKSEANIKQGE SDQPTKKDISENGNDVAIFTDVKNDHLMPNFNLHDQYCNSTNHDSHNHNNTVPDSFSQ LMSHLSEIDCDLTCDTPCTASTSATSGHKFVQDHQSSNNDDVFHKYCKFCEESTDNQP CSKHMHLESKPPQLPPKCSSLRKPTNTLQGTNHAYHEHILNTDMDLKILEDLCNISSL YEVPFGKHINHHDHNNAGNGCDGSSTGNNENGNQTMNLLLSSINRCNPKNNLNGSNNN TAGATSTDHQHHHHRIQFHSHKPNRNNIVNNSGISAANTTADLTNNDLNDLISREYSY ERFRNQSEPPSLPKVTHQNQKNRRSWPTKDLESTDFSSLEDSLPSSISPPIQTTSTIN FNWCFKEEKNNDLKCKWKECPESCSSLFDLQRHLLKDHVSQDFKHPMEPLACNWEDCD FLGDDTCSIVNHINCQHGINFDIQFANPDSFLPGSISKEKHHLLHCPNPQTHEVSKAD GAPDMTSANDVSNIPPIKQPEQVICQWDGCNKSFSSAQELNDHLEAVHLTRGKSEYQC LWHDCHRTFPQRQKLIRHLKVHSKYKPYKCKTCKRCFSSEETLVQHTRTHSGEKPYKC HICNKKFAISSSLKIHIRTHTGEKPLQCKICGKRFNESSNLSKHIKTHQKKYKCSDCS KSFDDLGKLNSQKVKCALERKPYL" gene 333357..334094 /gene="LOG1" /locus_tag="YJL055W" mRNA 333357..334094 /gene="LOG1" /locus_tag="YJL055W" /product="Log1p" CDS 333357..334094 /gene="LOG1" /locus_tag="YJL055W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0014074 response to purine-containing compound [PMID:15932646]" /note="hypothetical protein; functions together with HAM1 to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA, without affecting uptake or incorporation of uracil into RNA; proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA" /codon_start=1 /product="Log1p" /protein_id="DAA08743.1" /db_xref="SGD:S000003591" /translation="MTMEKNGGNSSRGGQVGGKSVCVYCGSSFGAKALYSESAEELGA LFHKLGWKLVYGGGTTGLMGKIARSTMGPDLSGQVHGIIPNALVSKERTDEDKEDVNK ALLESVENHKGATPISEEYGETTIVPDMHTRKRMMANLSDAFVAMPGGYGTFEEIMEC ITWSQLGIHNKPIILFNIDGFYDKLLEFLKHSIQERFISVKNGEIIQVASTPQEVVDK IEKYVVPEGRFNLNWSDEGHAHEDCAK" gene 334265..335701 /gene="TIM54" /locus_tag="YJL054W" mRNA 334265..335701 /gene="TIM54" /locus_tag="YJL054W" /product="Tim54p" CDS 334265..335701 /gene="TIM54" /locus_tag="YJL054W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:12637749]" /experiment="EXISTENCE:direct assay:GO:0042721 TIM22 mitochondrial import inner membrane insertion complex [PMID:10648604|PMID:10637294]" /experiment="EXISTENCE:genetic interaction:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:10637294|PMID:9412462]" /experiment="EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:9412462|PMID:17893242]" /note="Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane" /codon_start=1 /product="Tim22-complex subunit TIM54" /protein_id="DAA08744.1" /db_xref="SGD:S000003590" /translation="MSSESGKPIAKPIRKPGYTNPALKALGIPALRLPSRNWMIFWSV LTVSIGGIAYDKYKQRQILSHATDLVKPLAEESMEVDKVPRKITVFIAPPPNDYLESS LKVWRRYVKPVLYYAGLDYELVQEDRQGIIRTNVANRIRELRKEILASTDGQPVKEPN QTVAKPSGSSTSKISSLLPFNKIIQDPAEEDDSFDPEIGKKFKENFDWRNVIGIFYTM PKPKHIISEDALTKDPILSGGVICLGRGAYKEYIAGIHEGLLGPIEKTEKTGSTEPKM TGVVEANQIESKVSESGATELVDAEKETALEEAKVQDDLKVDEENSSEDSQKFLKPFI SSDQYPDLQIASELQTPNGEFIRNPNTNIPLLINQPLLVIPIPNLIGFTTIPRRIHRF YQKRFYVEDVCSSVVNCVRQTRIRPFDIAKDIDLAKDEEKDWPQNWVKQGKEKNSEWT QELVCDPRITKHMFVYEKPPKEEPESDI" gene 335898..337037 /gene="PEP8" /locus_tag="YJL053W" /gene_synonym="GRD6" /gene_synonym="VPS26" /gene_synonym="VPT4" mRNA 335898..337037 /gene="PEP8" /locus_tag="YJL053W" /gene_synonym="GRD6" /gene_synonym="VPS26" /gene_synonym="VPT4" /product="retromer subunit PEP8" CDS 335898..337037 /gene="PEP8" /locus_tag="YJL053W" /gene_synonym="GRD6" /gene_synonym="VPS26" /gene_synonym="VPT4" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:9700157]" /experiment="EXISTENCE:mutant phenotype:GO:0030904 retromer complex [PMID:9700157]" /experiment="EXISTENCE:mutant phenotype:GO:0030906 retromer, cargo-selective complex [PMID:9700157]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:8649377]" /experiment="EXISTENCE:mutant phenotype:GO:0140318 protein transporter activity [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0030904 retromer complex [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0140318 protein transporter activity [PMID:9700157]" /note="Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="retromer subunit PEP8" /protein_id="DAA08745.1" /db_xref="SGD:S000003589" /translation="MSIFFKPPIDIEILFDNEESRKHVDIATRSSNSSYKSMKESLPV YEDGESLGGIVTLRVRDSKKVDHLGIKVSVIGSIDMLKSHGSGNSSSKKVTSSTSSSS SNGSVDVRKNSVDQFLCQSYDLCPAGELQHSQSFPFLFRDLSKRYESYKGKNVDVAYY VKVTVMRKSTDISKIKRFWVYLYNSVTTAPNTLSANETKATTNDIAGGNYAADNASDN TQTKSTQGEAADVNQVLPISHSNNEPKPVRLDIGIENCLHIEFEYAKSQYSLKEVIVG RIYFLLTRLRIKHMELSLITRESSGLQTSNVMTDSTAIRYEIMDGSSVKGETIPIRLF LSGYDLTPNMSCNYFNVKNYLSLVIIDEDGRRYFKQSEITLYRTR" rep_origin 337281..337529 /note="ARS1011; Autonomously Replicating Sequence" /db_xref="SGD:S000028448" gene complement(337884..338003) /locus_tag="YJL052C-A" mRNA complement(337884..338003) /locus_tag="YJL052C-A" /product="hypothetical protein" CDS complement(337884..338003) /locus_tag="YJL052C-A" /note="hypothetical protein; identified based on comparison to related yeast species; mCherry fusion protein localizes to the vacuole" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08746.1" /db_xref="SGD:S000007610" /translation="MHLRSRWWLALLYCKDPVSRSATTPKVETRASCLLSRAF" gene 338271..339269 /gene="TDH1" /locus_tag="YJL052W" /gene_synonym="GLD3" mRNA 338271..339269 /gene="TDH1" /locus_tag="YJL052W" /gene_synonym="GLD3" /product="glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1" CDS 338271..339269 /gene="TDH1" /locus_tag="YJL052W" /gene_synonym="GLD3" /EC_number="1.2.1.12" /experiment="EXISTENCE:direct assay:GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [PMID:3905788]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16962558]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:10515935]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:11158358]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11158358]" /experiment="EXISTENCE:direct assay:GO:1904408 melatonin binding [PMID:31708896]" /experiment="EXISTENCE:expression pattern:GO:0006094 gluconeogenesis [PMID:3905788]" /experiment="EXISTENCE:expression pattern:GO:0006096 glycolytic process [PMID:3905788]" /experiment="EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]" /note="Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bacteria" /codon_start=1 /product="glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1" /protein_id="DAA08747.1" /db_xref="SGD:S000003588" /translation="MIRIAINGFGRIGRLVLRLALQRKDIEVVAVNDPFISNDYAAYM VKYDSTHGRYKGTVSHDDKHIIIDGVKIATYQERDPANLPWGSLKIDVAVDSTGVFKE LDTAQKHIDAGAKKVVITAPSSSAPMFVVGVNHTKYTPDKKIVSNASCTTNCLAPLAK VINDAFGIEEGLMTTVHSMTATQKTVDGPSHKDWRGGRTASGNIIPSSTGAAKAVGKV LPELQGKLTGMAFRVPTVDVSVVDLTVKLEKEATYDQIKKAVKAAAEGPMKGVLGYTE DAVVSSDFLGDTHASIFDASAGIQLSPKFVKLISWYDNEYGYSARVVDLIEYVAKA" gene 339787..342255 /gene="IRC8" /locus_tag="YJL051W" mRNA 339787..342255 /gene="IRC8" /locus_tag="YJL051W" /product="Irc8p" CDS 339787..342255 /gene="IRC8" /locus_tag="YJL051W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:13679573]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:18085829]" /note="Bud tip localized hypothetical protein; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc" /codon_start=1 /product="Irc8p" /protein_id="DAA08748.1" /db_xref="SGD:S000003587" /translation="MCHNSVRSGNKAGFLGIKFGSALLSIATGAIAIALLCKFHDHEA VLIVIVCSTLLYGIPSLISFITETVFAPSKFHIGYFYNVLNFALPLITMGCTVDYFHN TLRSPISVQSESHRVYITTLDSLLIFTLFINGIQLGFFLKDGNANNFGSSSNNISTDQ YDKEANAVENGRFVPLKNSSQTLTPDLELLHGSPKSMNGVAWLINELSTNSNTNANKT ISSDENSNSSVIRHKLGPISTSKCPKKPSHSHFSKLKKYNSFFLGPKENRYKRNTQQA TKVPTEKKSNHRSSQYVSRLSTISDISKSFLNFLALNEKNGNSTSTARTPSEGRVSII INEGNNTLKYKTPHDSHTIDSPNLELEREAIGRINSALLPACLRVTDKMISPQQSTQN EDSYQATPLIPQVEVDDDFYVGDILMTNELQDIPQVPRISSDIEDDFEQQYTKHVDLP ARVTLEMWEKDQEKILQKVTTNRDKSKLLPPFRFTSESDMDPSTSTELEVELHAQNNF SFPFKSAGLQIATSDQFNQQEFKTSDTISELDEYLHDPSIQEEDASQLIESSLNQNNL SSTTIDNGPKDMSRFSTRHSPTKSIISMISGSGSVKHQHSHSTLSNFFTGHSRNNSQI NQLLQGSSSNMMSNTSPHSSPTKSLRMRFGKKLSLSNISDTMSPYEGSTTDPINYSFG HGHNKNQSIDFSYVRTLQSSHSPTKSTSGNSRRDSLNNDRTQSTVNERALRTASTLFY LQHNNATCTLNGEEPVLDTPQSIQSSSSGSEQESAGSGSGYPEVVFSEYDREKWNVLR NLKEIAPEKTIESGPVEELVSPSK" gene 342522..345743 /gene="MTR4" /locus_tag="YJL050W" /gene_synonym="DOB1" mRNA 342522..345743 /gene="MTR4" /locus_tag="YJL050W" /gene_synonym="DOB1" /product="ATP-dependent RNA helicase MTR4" CDS 342522..345743 /gene="MTR4" /locus_tag="YJL050W" /gene_synonym="DOB1" /EC_number="3.6.4.13" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8756671|PMID:15226447]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:16541108]" /experiment="EXISTENCE:direct assay:GO:0008143 poly(A) binding [PMID:18096702]" /experiment="EXISTENCE:direct assay:GO:0031499 TRAMP complex [PMID:15935758|PMID:15935759|PMID:15828860]" /experiment="EXISTENCE:direct assay:GO:0034458 3'-5' RNA helicase activity [PMID:18096702|PMID:18000032]" /experiment="EXISTENCE:direct assay:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:15935758|PMID:15828860|PMID:17643380]" /experiment="EXISTENCE:genetic interaction:GO:0071028 nuclear mRNA surveillance [PMID:11586364]" /experiment="EXISTENCE:genetic interaction:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:18000032]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10508172|PMID:9463390]" /experiment="EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:27385342]" /experiment="EXISTENCE:mutant phenotype:GO:0016075 rRNA catabolic process [PMID:9463390|PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0034458 3'-5' RNA helicase activity [PMID:18000032]" /experiment="EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:10508172|PMID:10611222]" /experiment="EXISTENCE:mutant phenotype:GO:0034476 U5 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0071031 nuclear mRNA surveillance of mRNA 3'-end processing [PMID:17410208]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:16374505|PMID:18940861]" /experiment="EXISTENCE:mutant phenotype:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:19369424]" /experiment="EXISTENCE:mutant phenotype:GO:0071051 poly(A)-dependent snoRNA 3'-end processing [PMID:10611222]" /experiment="EXISTENCE:physical interaction:GO:0031499 TRAMP complex [PMID:15935759]" /note="RNA duplex-sensing translocase; ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing" /codon_start=1 /product="ATP-dependent RNA helicase MTR4" /protein_id="DAA08749.1" /db_xref="SGD:S000003586" /translation="MDSTDLFDVFEETPVELPTDSNGEKNADTNVGDTPDHTQDKKHG LEEEKEEHEENNSENKKIKSNKSKTEDKNKKVVVPVLADSFEQEASREVDASKGLTNS ETLQVEQDGKVRLSHQVRHQVALPPNYDYTPIAEHKRVNEARTYPFTLDPFQDTAISC IDRGESVLVSAHTSAGKTVVAEYAIAQSLKNKQRVIYTSPIKALSNQKYRELLAEFGD VGLMTGDITINPDAGCLVMTTEILRSMLYRGSEVMREVAWVIFDEVHYMRDKERGVVW EETIILLPDKVRYVFLSATIPNAMEFAEWICKIHSQPCHIVYTNFRPTPLQHYLFPAH GDGIYLVVDEKSTFREENFQKAMASISNQIGDDPNSTDSRGKKGQTYKGGSAKGDAKG DIYKIVKMIWKKKYNPVIVFSFSKRDCEELALKMSKLDFNSDDEKEALTKIFNNAIAL LPETDRELPQIKHILPLLRRGIGIHHSGLLPILKEVIEILFQEGFLKVLFATETFSIG LNMPAKTVVFTSVRKWDGQQFRWVSGGEYIQMSGRAGRRGLDDRGIVIMMIDEKMEPQ VAKGMVKGQADRLDSAFHLGYNMILNLMRVEGISPEFMLEHSFFQFQNVISVPVMEKK LAELKKDFDGIEVEDEENVKEYHEIEQAIKGYREDVRQVVTHPANALSFLQPGRLVEI SVNGKDNYGWGAVVDFAKRINKRNPSAVYTDHESYIVNVVVNTMYIDSPVNLLKPFNP TLPEGIRPAEEGEKSICAVIPITLDSIKSIGNLRLYMPKDIRASGQKETVGKSLREVN RRFPDGIPVLDPVKNMKIEDEDFLKLMKKIDVLNTKLSSNPLTNSMRLEELYGKYSRK HDLHEDMKQLKRKISESQAVIQLDDLRRRKRVLRRLGFCTPNDIIELKGRVACEISSG DELLLTELIFNGNFNELKPEQAAALLSCFAFQERCKEAPRLKPELAEPLKAMREIAAK IAKIMKDSKIEVVEKDYVESFRHELMEVVYEWCRGATFTQICKMTDVYEGSLIRMFKR LEELVKELVDVANTIGNSSLKEKMEAVLKLIHRDIVSAGSLYL" gene 345973..347325 /gene="CHM7" /locus_tag="YJL049W" mRNA 345973..347325 /gene="CHM7" /locus_tag="YJL049W" /product="Chm7p" CDS 345973..347325 /gene="CHM7" /locus_tag="YJL049W" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:33464310]" /experiment="EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:33464310]" /experiment="EXISTENCE:mutant phenotype:GO:0051292 nuclear pore complex assembly [PMID:33464310]" /note="Phosphatidic acid (PA)-binding nuclear envelope (NE)-specific ESCRT; homolog of human CHMP7, localizes to the endoplasmic reticulum presumably as part of ESCRT-III like complex" /codon_start=1 /product="phosphatidic acid-binding protein CHM7" /protein_id="DAA08750.1" /db_xref="SGD:S000003585" /translation="MKVDLPESRLPSLYRDFRPLKDLNPDGYEANISTWRDFFLQQYI SNSNRIIFTIGTRTLQELTHEVYGVPKSIDIAIDVLVNEGNLIPMELFNLGGMYTDNS RKGFWKWVRSWKESTNMYKSRKDETNFYLREDKFIIKANLEKEYQRFHELLKRSVFME ASSITDLVFTRNEFVTTESLQSFFSTYDEETKNVFLHFIENYKHIIVSKDNVIKVIAA EVEDITSRFSKGITENDLRIASVKVGIININKQITRLRKEINESNIKLRGPEFNELPK RIRIEYKQARLLSEKHLSRLLKFQNNLAQVRTQIDTSATNAVLIQTLSESNEVIKSIN GYIGSTEKVEDLLDEIKEGHDRTEEVNDLLAHYNKGQDEEAEEEIERELEQLELDEKN NNKEENKNQDLHEPKESSSEDLLKRLNNLKINTNEGPVQDNENHDNEIRKIMMEEQPR " gene complement(347447..348637) /gene="UBX6" /locus_tag="YJL048C" /gene_synonym="CUI2" mRNA complement(347447..348637) /gene="UBX6" /locus_tag="YJL048C" /gene_synonym="CUI2" /product="Ubx6p" CDS complement(347447..348637) /gene="UBX6" /locus_tag="YJL048C" /gene_synonym="CUI2" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14755638]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:14755638]" /experiment="EXISTENCE:mutant phenotype:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:14755638]" /note="UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication" /codon_start=1 /product="Ubx6p" /protein_id="DAA08751.1" /db_xref="SGD:S000003584" /translation="MYEMSGIDSLFHDRVVHDYSHTSEQVIVVYISSAAGDNSWLHQW FKPGNLSDEERENILWVRLVNGTKECLLFKSIFPSSSAPSINILQNGLLECSIQGNSL SREQDPWETFINGLQSVFKGQVTKRKLFSKSNEEYQRVKRMIQNDKLERKYVFQNTND PQRKPQKWKQLTVTDNVSYKSQKGFLAQNYCTLQLKLPNGYTISNTFPPQTKLHKVRM WLDYNCYDDGTPYLFHRNIPRVTLTRNDELKSLQELDLLPRSTLILEPLEANNKTFDY MEQSSLLHKVYSGLTSFWAKEPEVDASSSRLGYQRLGTNVSNSANYSLQKLSSLDMVS DGGGGGGGDSMTPSAYTTPRMYPSNGTSQLRQNVSELNLSSNNSASNTKVRTLGYSNN NGNN" gene complement(349044..349178) /locus_tag="YJL047C-A" mRNA complement(349044..349178) /locus_tag="YJL047C-A" /product="hypothetical protein" CDS complement(349044..349178) /locus_tag="YJL047C-A" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08752.1" /db_xref="SGD:S000028804" /translation="MKIKISIEISLSLLSEHYKRNENCISNMLVIGEGPRGETIVERF " gene complement(349130..349233) /gene="SNR60" /locus_tag="YNCJ0009C" ncRNA complement(349130..349233) /ncRNA_class="snoRNA" /gene="SNR60" /locus_tag="YNCJ0009C" /product="SNR60" /experiment="EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]" /experiment="EXISTENCE:curator inference:GO:0031428 box C/D methylation guide snoRNP complex [PMID:10024243]" /experiment="EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]" /experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]" /note="C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at positions A817 and G908" /db_xref="SGD:S000006451" gene complement(349580..352108) /gene="RTT101" /locus_tag="YJL047C" /gene_synonym="CUL8" mRNA complement(349580..352108) /gene="RTT101" /locus_tag="YJL047C" /gene_synonym="CUL8" /product="cullin RTT101" CDS complement(349580..352108) /gene="RTT101" /locus_tag="YJL047C" /gene_synonym="CUL8" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:12676951]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0035361 Cul8-RING ubiquitin ligase complex [PMID:20139071]" /experiment="EXISTENCE:mutant phenotype:GO:0007088 regulation of mitotic nuclear division [PMID:12676951]" /experiment="EXISTENCE:mutant phenotype:GO:0010526 transposable element silencing [PMID:11779788]" /experiment="EXISTENCE:mutant phenotype:GO:0031297 replication fork processing [PMID:18704118]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:19390089|PMID:22505030]" /note="Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; role in anaphase progression; Rtt101p-Mms22p ligase associates with replisome complex during S phase via Ctf4p; required for recovery after DSB repair; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p" /codon_start=1 /product="cullin RTT101" /protein_id="DAA08753.1" /db_xref="SGD:S000003583" /translation="MINESVSKREGFHESISRETSASNALGLYNKFNDERNPRYRTMI AELHEFFHLTLAETITETDVKELECNKEKAAKFRKLMPKMLNNCRELTQRKSYIPYNS EFNGNDEKQKKFQLLHQHQIVLSFQEFCDELAKLIIDAHVLSFLTRCDYSYEIIPKNW TSFYKLFQYVMGAVGPIISYVPVNYPMIRKELGFETLTIFQYYDSKLFECMKSHFGRE FSTLVSATIHHYIHMFPITNTMLEKEVPMLRIMSNCNFSIEGLSPKDFYMKTLRQYYC EESNLRPRLETFKNFKVLLTRNALLASLFSPEWVSDANDLFISHLLLNKKSISEYIEI GKDTYDEEKERYFKTETHFSLLMFRNAFEAKNMLSKFKEFCDDAVSEKLKAAYGSNHD TERLFDEVVQLANVDHLKIYSDSIEYHLCNLLGSTSKAIEQYVKYFESHLFIIVRKIK TTKKDLPRDMKIKYLNENLPILRLKFVNLPTFPNFFERSIFRKTILQSDQNSSFIKDI LPVYKDSLMELFKQRIITNVSQEDEMRYRDQYQPYLSQFFQPVEVMADLRIKYASFLS FYENIEAAVKFGKTYNENNSKSFFPLIFDRERIPKVFQQSNEVKKNFVLPQEMDDTWN QFLRNYHEQNKVEDSDASKKELYPMWNLHHCEVESPYIIQDGTNLIFELTLFQTCVLT LFNESDHLTLQVISEQTKLAYKDLALVLKSFCNYKILTRDIDNTYSINESFKPDMKKV KNGKLRVVLPRTASLQSSNTGGERTSSAHHEGSNSQWTQELLKACITRSVKSERNGLD YDHLFETVKQQIKGFSVGEFKDALAKLLRDKFITRDESTATYKY" gene 352386..353615 /gene="AIM22" /locus_tag="YJL046W" /gene_synonym="LIP3" /gene_synonym="RRG3" mRNA 352386..353615 /gene="AIM22" /locus_tag="YJL046W" /gene_synonym="LIP3" /gene_synonym="RRG3" /product="putative lipoate--protein ligase" CDS 352386..353615 /gene="AIM22" /locus_tag="YJL046W" /gene_synonym="LIP3" /gene_synonym="RRG3" /EC_number="6.3.1.20" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19570983]" /experiment="EXISTENCE:mutant phenotype:GO:0009249 protein lipoylation [PMID:19570983]" /note="Lipoate-protein ligase; octanoyl-CoA: protein transferase required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss" /codon_start=1 /product="putative lipoate--protein ligase" /protein_id="DAA08754.1" /db_xref="SGD:S000003582" /translation="MSMMLSNWALSPRYVGQRNLIHCTTLFHTLTRWAKDADDKYHDI NSMYENMFTPSNDNVSILQDEGKSDYDTTKASSMEEDISAFNKDLYNFYNIGYAKQIM SASQLENIVKAKGRFVIQSLSTSPYYNLALENYVFKNTPRAKRGPDNCRLLFYINDRC AVIGKNQNLWQEVDLAKLKSKNFELLRRFSGGGTVLHDLGNVNYSYLTSREKFETKFF NKMIIKWLNSLNPELRLDLNERGDIIQDGFKISGSAYKIAGGKAYHHATMLLNADLEQ FSGLLEPSLPNNMEWESSGVHSVKSKIKNVGIITPNQFIAVVSERFQKTFKVDGEIPI YYCDEFKSINDEIKDAMNTLQSEQWKYFSGPKFSVKIKDKGLTIKVEKGMIYDCDRND LIGLEFKGFLENIDSYT" gene 354244..354332 /gene="SUP7" /locus_tag="YNCJ0010W" tRNA join(354244..354282,354297..354332) /gene="SUP7" /locus_tag="YNCJ0010W" /product="tRNA-Tyr" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Tyrosine tRNA (tRNA-Tyr), predicted by tRNAscan-SE analysis; can mutate to suppress ochre nonsense mutations" /db_xref="SGD:S000006781" repeat_region complement(354538..355204) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007023" repeat_region complement(354844..355175) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007024" gene 355374..355445 /locus_tag="YNCJ0011W" tRNA 355374..355445 /locus_tag="YNCJ0011W" /product="tRNA-Arg" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Arginine tRNA (tRNA-Arg), predicted by tRNAscan-SE analysis; one of 11 nuclear tRNA genes containing the tDNA-anticodon UCU (converted to mcm5-UCU in the mature tRNA), decodes AGA codons into arginine, one of 19 nuclear tRNAs for arginine" /db_xref="SGD:S000006714" gene 355456..355527 /locus_tag="YNCJ0012W" tRNA 355456..355527 /locus_tag="YNCJ0012W" /product="tRNA-Asp" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Aspartate tRNA (tRNA-Asp), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006537" gene 356024..357928 /gene="SDH9" /locus_tag="YJL045W" mRNA 356024..357928 /gene="SDH9" /locus_tag="YJL045W" /product="succinate dehydrogenase SDH9" CDS 356024..357928 /gene="SDH9" /locus_tag="YJL045W" /EC_number="1.3.5.1" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:genetic interaction:GO:0008177 succinate dehydrogenase (quinone) activity [PMID:16232921|PMID:9730279]" /experiment="EXISTENCE:genetic interaction:GO:0045333 cellular respiration [PMID:9730279|PMID:16232921]" /experiment="EXISTENCE:mutant phenotype:GO:0008177 succinate dehydrogenase (quinone) activity [PMID:16232921]" /experiment="EXISTENCE:mutant phenotype:GO:0045333 cellular respiration [PMID:16232921]" /note="Minor succinate dehydrogenase isozyme; participates in oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner; YJL045W has a paralog, SDH1, that arose from the whole genome duplication" /codon_start=1 /product="succinate dehydrogenase SDH9" /protein_id="DAA08755.1" /db_xref="SGD:S000003581" /translation="MLSLKKGITKSYILQRTFTSSSVVRQIGEVKSESKPPAKYHIID HEYDCVVVGAGGAGLRAAFGLAEAGYKTACLSKLFPTRSHTVAAQGGINAALGNMHPD DWKSHMYDTVKGSDWLGDQDAIHYMTREAPKSVIELEHYGMPFSRTEDGRIYQRAFGG QSKDFGKGGQAYRTCAVADRTGHAMLHTLYGQALKNNTHFFIEYFAMDLLTHNGEVVG VIAYNQEDGTIHRFRAHKTVIATGGYGRAYFSCTSAHTCTGDGNAMVSRAGFPLEDLE FVQFHPSGIYGSGCLITEGARGEGGFLLNSEGERFMERYAPTAKDLASRDVVSRAITM EIRAGRGVGKNKDHILLQLSHLPPEVLKERLPGISETAAVFAGVDVTQEPIPVLPTVH YNMGGIPTKWTGEALTIDEETGEDKVIPGLMACGEAACVSVHGANRLGANSLLDLVVF GRAVANTIADTLQPGLPHKPLASNIGHESIANLDKVRNARGSLKTSQIRLNMQRTMQK DVSVFRTQDTLDEGVRNITEVDKTFEDVHVSDKSMIWNSDLVETLELQNLLTCATQTA VSASKRKESRGAHAREDYAKRDDVNWRKHTLSWQKGTSTPVKIKYRNVIAHTLDENEC APVPPAVRSY" gene complement(358300..359676) /gene="GYP6" /locus_tag="YJL044C" mRNA complement(358300..359676) /gene="GYP6" /locus_tag="YJL044C" /product="GTPase-activating protein GYP6" CDS complement(358300..359676) /gene="GYP6" /locus_tag="YJL044C" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:8441469]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:35134079]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:14610088]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:24924636]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0090630 activation of GTPase activity [PMID:8441469]" /note="GTPase-activating protein (GAP) for yeast Rab family member Ypt6p; involved in vesicle mediated protein transport" /codon_start=1 /product="GTPase-activating protein GYP6" /protein_id="DAA08756.1" /db_xref="SGD:S000003580" /translation="MKDVLQWAIDHYETRDQLVQKGIWKGELYHDSIFKENSRGWLWK ALLLCDENNNCLLTDNFKGLDLNQFGLVPVPMLADGDNYDENHNANVPKRVLHSNVSS SVGIRRLTPVEAVEKHPLSDDNDKTKGSLSKGSDEKPLTLRETLEIIDLDLSRIMLDD IFQEPKVHAQMRQLLYNYLLIHQSEHLQYKQGFHEILSVIYLQLYHGTDLDNTDLQNV LIIFNKLMNQIEPIFYNEENLINWDKRVFTKIFRICLPDLFSKVFYQPPKTGSGKKKN VDHLIHSNLIWLIRWTRLLFLRELPLKYVLIVWDHVLTFNYPLDIFIACTIITLLLSI YDELHELVSQGDYEHTNNNDEFVELILHFKKIFEKEDASKDDEKFLDLCKVTGNLCEL WYGKNYDDMRLICDTFINAKFGIKTSDVLSMETAKLTIDPNRQSLENKLRERVRQTIL KNKKKISQ" gene 360130..360903 /locus_tag="YJL043W" mRNA 360130..360903 /locus_tag="YJL043W" /product="hypothetical protein" CDS 360130..360903 /locus_tag="YJL043W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="hypothetical protein; YJL043W is a non-essential gene" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08757.1" /db_xref="SGD:S000003579" /translation="MFVDYSGLERYTDINASFGKLVNTYCCFQRCEAISEQLEILKSL VPKCHDIVALTDEDFASGRTAGLTQKLFAMAMTLHQITDCIDLLQKCNTIIPIEIANP ASFESGAATAPLRQSYARLLDDWSHYMGPSTVKHTGCTNRPKWRFPWQQSRTIIIPML FIGETAMSTRDLRSVLHDCEIRHASEMPLQLLWTSSPELVYATPHVDDYDIWSRYGSD YNMQIEDEDEASKGRQRKCVVQLEALLGALPTTDPLFQW" gene 361249..365445 /gene="MHP1" /locus_tag="YJL042W" mRNA 361249..365445 /gene="MHP1" /locus_tag="YJL042W" /product="Mhp1p" CDS 361249..365445 /gene="MHP1" /locus_tag="YJL042W" /experiment="EXISTENCE:direct assay:GO:0005200 structural constituent of cytoskeleton [PMID:9855114]" /experiment="EXISTENCE:direct assay:GO:0005874 microtubule [PMID:8947554]" /experiment="EXISTENCE:mutant phenotype:GO:0007026 negative regulation of microtubule depolymerization [PMID:9855114]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:9090049]" /note="Microtubule-associated protein involved in microtubule organization; involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins" /codon_start=1 /product="Mhp1p" /protein_id="DAA08758.1" /db_xref="SGD:S000003578" /translation="MDSKDTQKLLKEHRIPCIDVGWLVRPSASTSKSSRPGKSESKAN SVAPDIQMDTARPPVFETSVDSSSSILSSNDKGRRHSVAASLLMDNQRANAGSTSVPT NIPPPRGRSKSVVETNLSNVEADSGHHHHHRHHHHTEDAPAPKKVGFFKSLFGHRKKD QEQQEKERERKERSPSPTHVDRGAAIRRERTATISAESPPPLQYNAPPSYNDTVVPLT RSKTESEVYYENHPQSYYHGRMRTYHSPEEGKVDGTSPADDHNYGGSRPDPRLMDFLR YYKSKDYKLAAFKEGNFIKSSASPTTKKNRRASFSLHNDKPQPAKSLAHQKFDAKGRP IPPHPDAPKLPSAFRKKHPSNASIVDTVDSNSDVSSSAQNNNQTPSSHKFGAFLRKVT SYGNNNNNSTNASSLSANVNNPDTSSTSLWSSSSMEFDPSKITTVPGLENIRPLKHVS FATNTYFNDPPQQICSKNPRKGEVEVKPNGSVVIHRLTPQERKKIMESTSLGVVVGGT GQLKLLNPEEDDANAKSKEEMAPQKQNEVEAHDEEDNNSQRRNIVMAAAEAAAEARAK EAPNELKRIVTNNEEEVTVSKTASHLTIDKPMISRRGASTSSLASMVSSDTNGTNADD EGEILPPPSLKIPHDIVYTRCCHLREILPIPATLKQLKKGSTDPIPILQLRNPRPSMV EIWSFSDFLSIAPVLCLSLDGVQLTVQMLRIILSSLVYKQHFQKLSLRNTPLDEEGWK VLCYFVSKAKSLHSIDLTMVPSIKTNVQKPSKSSLKSKILRMQCNLENRSDMNWDLLT ASIALMGGLEEIVISGAKMNSAQFKNFILVACIATERLGLAYNGLSKSQCDDLAKWMV QSKVTGLDVGFNDLNGKLSSFTDAVLGKIQKANEKNVFKFLSLNGTNLRVNEHDTFEN NEVLKLISVLCYLENLKFLDISNNPAIFPHCVPTLIDFLPVFVNLVRLHIDYNNLSST SVVMLAEILPMCSRLNYFSMLGTELDLASSKALAEAVRKSSSLMTLDVDYVYMPENIK EKISLYALRNIQGELKRVNSDDKDIKDSQFSSLQDQLSLLLTEKADNSEHYNKMVENF MAKIALARIKISKVVHDLFDLKLNGQLNLEGKEALIRLCFIEASLERGCDLLKQRHNN TLKSPEAVSKSRKGGNQAQPNSESCQRMLLSSSILQNSDHIALMPFGSAIVEKSSPDA EDAVEFREGDDSNVNHEDVPANDQQFRDEVDIKNKYSIIKRELEHEKLVGGGDLPVDK EILNRAAQSLDSDQIKEFLLKNDVSTILGVIDELHSQGYHLHHIFKKQGNQEETAFRT KDEQQSSQSNDSSANASPTTDPISTGSNTSRTNDNAHIPPTDAPGFDKFMNNAEENAI DAAYDDVLDKIQDARNSSTK" gene 365784..368373 /gene="NSP1" /locus_tag="YJL041W" mRNA join(365784,365903..368373) /gene="NSP1" /locus_tag="YJL041W" /product="FG-nucleoporin NSP1" CDS join(365784,365903..368373) /gene="NSP1" /locus_tag="YJL041W" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:17897934]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:2112428]" /experiment="EXISTENCE:direct assay:GO:0017056 structural constituent of nuclear pore [PMID:19098896|PMID:19680227]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406|PMID:9813081|PMID:24574455]" /experiment="EXISTENCE:direct assay:GO:0044615 nuclear pore nuclear basket [PMID:9813081]" /experiment="EXISTENCE:genetic interaction:GO:0006607 NLS-bearing protein import into nucleus [PMID:15039779]" /experiment="EXISTENCE:genetic interaction:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:10952996]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11071906|PMID:9971735|PMID:11739405]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:11739405]" /experiment="EXISTENCE:mutant phenotype:GO:0006405 RNA export from nucleus [PMID:11352936]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:8524308]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:12730220|PMID:2112428]" /experiment="EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:19098896|PMID:17418788|PMID:12169684]" /note="FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p)" /codon_start=1 /product="FG-nucleoporin NSP1" /protein_id="DAA08759.1" /db_xref="SGD:S000003577" /translation="MNFNTPQQNKTPFSFGTANNNSNTTNQNSSTGAGAFGTGQSTFG FNNSAPNNTNNANSSITPAFGSNNTGNTAFGNSNPTSNVFGSNNSTTNTFGSNSAGTS LFGSSSAQQTKSNGTAGGNTFGSSSLFNNSTNSNTTKPAFGGLNFGGGNNTTPSSTGN ANTSNNLFGATANANKPAFSFGATTNDDKKTEPDKPAFSFNSSVGNKTDAQAPTTGFS FGSQLGGNKTVNEAAKPSLSFGSGSAGANPAGASQPEPTTNEPAKPALSFGTATSDNK TTNTTPSFSFGAKSDENKAGATSKPAFSFGAKPEEKKDDNSSKPAFSFGAKSNEDKQD GTAKPAFSFGAKPAEKNNNETSKPAFSFGAKSDEKKDGDASKPAFSFGAKPDENKASA TSKPAFSFGAKPEEKKDDNSSKPAFSFGAKSNEDKQDGTAKPAFSFGAKPAEKNNNET SKPAFSFGAKSDEKKDGDASKPAFSFGAKSDEKKDSDSSKPAFSFGTKSNEKKDSGSS KPAFSFGAKPDEKKNDEVSKPAFSFGAKANEKKESDESKSAFSFGSKPTGKEEGDGAK AAISFGAKPEEQKSSDTSKPAFTFGAQKDNEKKTEESSTGKSTADVKSSDSLKLNSKP VELKPVSLDNKTLDDLVTKWTNQLTESASHFEQYTKKINSWDQVLVKGGEQISQLYSD AVMAEHSQNKIDQSLQYIERQQDELENFLDNFETKTEALLSDVVSTSSGAAANNNDQK RQQAYKTAQTLDENLNSLSSNLSSLIVEINNVSNTFNKTTNIDINNEDENIQLIKILN SHFDALRSLDDNSTSLEKQINSIKK" gene complement(368748..373799) /gene="NUP192" /locus_tag="YJL039C" mRNA complement(368748..373799) /gene="NUP192" /locus_tag="YJL039C" /product="Nup192p" CDS complement(368748..373799) /gene="NUP192" /locus_tag="YJL039C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0044611 nuclear pore inner ring [PMID:18046406]" /experiment="EXISTENCE:mutant phenotype:GO:0006999 nuclear pore organization [PMID:10428845|PMID:11121302]" /experiment="EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:10428845]" /experiment="EXISTENCE:mutant phenotype:GO:0046822 regulation of nucleocytoplasmic transport [PMID:23499021]" /note="Essential subunit of inner ring of nuclear pore complex (NPC); plays a role in modulating transport through the NPC; homologous to human NUP205" /codon_start=1 /product="Nup192p" /protein_id="DAA08760.1" /db_xref="SGD:S000003576" /translation="MKWSAIPFQTLYRSIESGEFDFDLFKEVLPDLQNLNLNTDKLKN NASRSQLEKGEIELSDGSTFKVNQEFIFEAISLSDELNLDEIVACELILSGDTTANNG KVQYFLRRQYILQIVSFIVNCFHEDTELYQELIKNGALVSNILSAFKFIHTQLSEIKQ QINKAQILENYNALFQQNIKFRRDFLLREYDILSQILYGLVDKGAIMKNKDFILSLLH HVSELDSNDFFIIYYTPAFFHLFASLRVLPDADVKLLHSQFMKDLKDDSIYTKPVKVA LIFIFFAYFIGWCKEDPKRRADTMDFKTDVDEPMTSAVELGAIEQILIFAADTSIVEQ DKSMELFYDIRSLLERHIPRLIPKQLLDDEKIFSQTTNSTYNPASATDNMSGRGLWNP SYPGMMSTTGTARLNSMPNNVNEYSYTTIVLSDQTQEFFLSSFDDVLQTIITDCAFLL TKIKDAEEDSLLSGEDLTLDDISLKADLERFFLSIYFFYASRPEYSCTFWSDKESNAY GFIEWCSRCNDNLMRSCFYLMVSSLSFGPENALNVYHYFGENSSISWKNIAQCLSDYT KKISNFNSSLHKRQQFSESTHNDIDSTAVALEEGLNEEAVIFLSSLLTLVGSVTYQVD EDVKSSLSKVFSDVLFEFTKINTPLVGAAFKVISNLVPKLESSRTKFWSFLDSLIFKD SSLNYSSESYRNAFTNVLTKYSDVLGFLQLFHNLISIHSRENNSEYMVFGKLAFPTRL GQGYRKVGIWPYFDYIFNDILAHVDQIVDIRNKRAVQLPILKIIYTGLCSFDYSVILN SIPAAANLDALVDCENFFNYVQECPAIPIFNYIFTEKIYKSIFNVVDVGVDQLSIELE GGKNQAELLQLAVKIINKVLDYQETYVEELFPIVKKHGKTDYFLPKNYSLHGLRSFYD AIFFNIPLVAHLGLYVGVDDQILATNSLRILAKLSERSNGSVASLSKRNKLLTIFDSV DESARIKDAFITQLESSITDAGVLALKLELLDFLTSNLSNYSRTMTISHLLLGFQVSN VISLGPNLATFISSGTSLLDSLISVLEASLNSITKDNIDYAPMRLATAALEIILKLCR NPLTSGLLYSYLIKENFFERIMILDPQVTRFTTWNGSPFDNSTEEKCKNFIESESVGA FLSFLAYRNYWTQYLGLFIHKISFSGTKSEVLTYVNYLISNTMYSVRLFSFLDPLNYG NICEPKETLSIFTNVPLNLEQVTLNKYCSGNIYDFHKMENLMRLIKRVRAESLHSNSF SLTVSKEQFLKDADVECIKAKSHFTNIISRNKALELNLSVLHSWVQLVQIIVTDGKLE PSTRSNFILEVFGTIIPKISDYIEFNITFSEELVSLAVFLFDIYNRDRKLITDKGTVD GRLYQLFKTCIQGINSPLSSVALRSDFYILANHYLSRVLSDQVGSEKVLQDLRLGSKK LVEIIWNDVVYGEGTSRVTGILLLDSLIQLANRSKENFILDSLMKTTRLLLIIRSLKN TDALLNSTTEHINIDDLLYELTAFKATVFFLIRVAETRGGASALIENNLFRIIAELSF LKVDPDLGLDLMFDEVYVQNSKFLKVNVTLDNPLLVDKDANGVSLFELIVPIFQLISA VLVSMGSSNKAVVQTVKGLLNTYKRLVIGIFKRDLLREKEDKKNSSDPNNQSLNEMVK LIVMLCTLTGYQNND" gene complement(374424..374495) /locus_tag="YNCJ0013C" tRNA complement(374424..374495) /locus_tag="YNCJ0013C" /product="tRNA-Asp" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Aspartate tRNA (tRNA-Asp), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006538" gene complement(374506..374577) /locus_tag="YNCJ0014C" tRNA complement(374506..374577) /locus_tag="YNCJ0014C" /product="tRNA-Arg" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Arginine tRNA (tRNA-Arg), predicted by tRNAscan-SE analysis; one of 11 nuclear tRNA genes containing the tDNA-anticodon UCU (converted to mcm5-UCU in the mature tRNA), decodes AGA codons into arginine, one of 19 nuclear tRNAs for arginine" /db_xref="SGD:S000006715" repeat_region complement(374844..374935) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007025" rep_origin 374880..375122 /note="ARS1012; Autonomously Replicating Sequence" /db_xref="SGD:S000028449" gene complement(375115..375774) /gene="LOH1" /locus_tag="YJL038C" /gene_synonym="OSW4" mRNA complement(375115..375774) /gene="LOH1" /locus_tag="YJL038C" /gene_synonym="OSW4" /product="Loh1p" CDS complement(375115..375774) /gene="LOH1" /locus_tag="YJL038C" /gene_synonym="OSW4" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:23966878]" /experiment="EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:18562670]" /note="Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to adjacent ORF, IRC18/YJL037W, and the irc18 loh1 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants; SWAT-GFP and mCherry fusion proteins localize to the cytosol; proposed role in maintenance of genome integrity" /codon_start=1 /product="Loh1p" /protein_id="DAA08761.1" /db_xref="SGD:S000003575" /translation="MRFQLFIYFYFTIVVIAGTNTIQQFSDAGDRLITSLRNLDNNGT YETLTAEKVPIIEGQIQNISAKYEQHTFILKGLEAVLNYKVKSLDNNERESLEIEYEK VEKALDAALNVSPFEYIKKFKEVSRGKVVNALENLSREQNRITINGGREDEKEKEARE KKKRLDRIKRILTVSLLELGLAQGVADLCAVAPFACLLGVTVGSIGFIFWLALIYNAI Q" rep_origin 375706..376227 /note="ARS1013; Autonomously Replicating Sequence; inefficient as chromosomal replication origin; replication capacity dependent upon Sum1p" /db_xref="SGD:S000028450" gene 376662..377336 /gene="IRC18" /locus_tag="YJL037W" /gene_synonym="OSW6" mRNA 376662..377336 /gene="IRC18" /locus_tag="YJL037W" /gene_synonym="OSW6" /product="Irc18p" CDS 376662..377336 /gene="IRC18" /locus_tag="YJL037W" /gene_synonym="OSW6" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:23966878]" /note="Protein involved in outer spore wall assembly; possible role in assembly of the dityrosine layer; similar to adjacent ORF, LOH1; irc18 loh1 double mutant exhibits reduced dityrosine fluorescence relative to single mutants; SWAT-GFP fusion protein localizes to the ER and vacuole, while mCherry fusion localizes to the vacuole; expression induced in respiratory-deficient cells and carbon-limited chemostat culture; null mutant displays increased levels of spontaneous Rad52p foci" /codon_start=1 /product="Irc18p" /protein_id="DAA08762.1" /db_xref="SGD:S000003574" /translation="MKVQMIERIFLIQLCLLTVVLASSRAVVEFESTGTKLVNSLRVL AAYSQSSVCVDEKISGIERQIEEVKDMYGNHSFILKGLNGILNNKVNMLTREIQMETV GNNTFETETGKLTKGLNRAVNISPFKYIKKFKTVSTKKFESLLNKYDLVAKKGGELTE EQKKKKEVLSRISRVVAATTIEAGLAQGVVDLCITVTTSLCLVSASIGGVGFLIWLTI IYQALT" repeat_region complement(377598..377870) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007026" gene 378360..378433 /locus_tag="YNCJ0015W" tRNA 378360..378433 /locus_tag="YNCJ0015W" /product="tRNA-Val" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Valine tRNA (tRNA-Val), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006759" gene 378825..380096 /gene="SNX4" /locus_tag="YJL036W" /gene_synonym="ATG24" /gene_synonym="CVT13" mRNA 378825..380096 /gene="SNX4" /locus_tag="YJL036W" /gene_synonym="ATG24" /gene_synonym="CVT13" /product="Snx4p" CDS 378825..380096 /gene="SNX4" /locus_tag="YJL036W" /gene_synonym="ATG24" /gene_synonym="CVT13" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:12048214|PMID:18497569]" /experiment="EXISTENCE:direct assay:GO:0005769 early endosome [PMID:17420293]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12048214|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:12554655|PMID:11557775]" /experiment="EXISTENCE:direct assay:GO:0048471 perinuclear region of cytoplasm [PMID:33678121]" /experiment="EXISTENCE:genetic interaction:GO:0034498 early endosome to Golgi transport [PMID:12554655]" /experiment="EXISTENCE:genetic interaction:GO:0036010 protein localization to endosome [PMID:29511122]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12554655]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:12048214|PMID:12554655]" /experiment="EXISTENCE:mutant phenotype:GO:0032456 endocytic recycling [PMID:32074001]" /experiment="EXISTENCE:mutant phenotype:GO:0034498 early endosome to Golgi transport [PMID:12554655]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0061723 glycophagy [PMID:38832010]" /experiment="EXISTENCE:physical interaction:GO:0034498 early endosome to Golgi transport [PMID:12554655]" /note="Sorting nexin; involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p" /codon_start=1 /product="Snx4p" /protein_id="DAA08763.1" /db_xref="SGD:S000003573" /translation="MTDKGKNDLTSKAKDKARGNPEKPPYWFEIIVSDPQKRTGDPGS SSGYVSYQISTKTNNTSFYDNRGDPESIIVVHRRYSDLLLLHDILLNRFPTCIIPPLP DKKVFQYIAGDRFSQRFTQKRCHSLQNFLRRVSLHPDLSQSKVFKTFLVSKDWESHRK VLQDSLQPNKDEVTDAFMNAFKTVHKQNEEFTEIREKSDKLDRTVTKIDKLFHKVVKK NDSMSEDYTKLGSNLQELQELVTGENEELAAKLKIFNEGVTQLSYGLQDLTKYLDYEY IVDLKDLEHYIDSMRQLIKLKDQKQIDYEELSDYLTRSIKEKNNLISGYGGSNFFANK LEELAGINQEASRREKINKLEGKITSLTGELENAKKVADGFEQECLKEIDHFESVKTA EIKKSLGSLADHHIEFYERILEAWEKVDDSL" gene complement(380249..381001) /gene="TAD2" /locus_tag="YJL035C" mRNA complement(380249..381001) /gene="TAD2" /locus_tag="YJL035C" /product="tRNA(adenine34) deaminase" CDS complement(380249..381001) /gene="TAD2" /locus_tag="YJL035C" /EC_number="3.5.4.33" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:10550050]" /experiment="EXISTENCE:direct assay:GO:0008251 tRNA-specific adenosine deaminase activity [PMID:10550050]" /note="Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs" /codon_start=1 /product="tRNA(adenine34) deaminase" /protein_id="DAA08764.1" /db_xref="SGD:S000003572" /translation="MQHIKHMRTAVRLARYALDHDETPVACIFVHTPTGQVMAYGMND TNKSLTGVAHAEFMGIDQIKAMLGSRGVVDVFKDITLYVTVEPCIMCASALKQLDIGK VVFGCGNERFGGNGTVLSVNHDTCTLVPKNNSAAGYESIPGILRKEAIMLLRYFYVRQ NERAPKPRSKSDRVLDKNTFPPMEWSKYLNEEAFIETFGDDYRTCFANKVDLSSNSVD WDLIDSHQDNIIQELEEQCKMFKFNVHKKSKV" gene 381327..383375 /gene="KAR2" /locus_tag="YJL034W" /gene_synonym="GRP78" mRNA 381327..383375 /gene="KAR2" /locus_tag="YJL034W" /gene_synonym="GRP78" /product="Hsp70 family ATPase KAR2" CDS 381327..383375 /gene="KAR2" /locus_tag="YJL034W" /gene_synonym="GRP78" /EC_number="3.6.4.10" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:2661018]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:1325440]" /experiment="EXISTENCE:direct assay:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:10367885]" /experiment="EXISTENCE:direct assay:GO:0034099 luminal surveillance complex [PMID:16873065]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:23704572]" /experiment="EXISTENCE:genetic interaction:GO:0070880 fungal-type cell wall beta-glucan biosynthetic process [PMID:9430631]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:10069807]" /experiment="EXISTENCE:mutant phenotype:GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation [PMID:7568189]" /experiment="EXISTENCE:mutant phenotype:GO:0006986 response to unfolded protein [PMID:12808051]" /experiment="EXISTENCE:mutant phenotype:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:7568189]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:11381090]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:12808051]" /experiment="EXISTENCE:mutant phenotype:GO:0070972 protein localization to endoplasmic reticulum [PMID:1996357]" /note="ATPase involved in protein import into the ER; also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p" /codon_start=1 /product="Hsp70 family ATPase KAR2" /protein_id="DAA08765.1" /db_xref="SGD:S000003571" /translation="MFFNRLSAGKLLVPLSVVLYALFVVILPLQNSFHSSNVLVRGAD DVENYGTVIGIDLGTTYSCVAVMKNGKTEILANEQGNRITPSYVAFTDDERLIGDAAK NQVAANPQNTIFDIKRLIGLKYNDRSVQKDIKHLPFNVVNKDGKPAVEVSVKGEKKVF TPEEISGMILGKMKQIAEDYLGTKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVLRI VNEPTAAAIAYGLDKSDKEHQIIVYDLGGGTFDVSLLSIENGVFEVQATSGDTHLGGE DFDYKIVRQLIKAFKKKHGIDVSDNNKALAKLKREAEKAKRALSSQMSTRIEIDSFVD GIDLSETLTRAKFEELNLDLFKKTLKPVEKVLQDSGLEKKDVDDIVLVGGSTRIPKVQ QLLESYFDGKKASKGINPDEAVAYGAAVQAGVLSGEEGVEDIVLLDVNALTLGIETTG GVMTPLIKRNTAIPTKKSQIFSTAVDNQPTVMIKVYEGERAMSKDNNLLGKFELTGIP PAPRGVPQIEVTFALDANGILKVSATDKGTGKSESITITNDKGRLTQEEIDRMVEEAE KFASEDASIKAKVESRNKLENYAHSLKNQVNGDLGEKLEEEDKETLLDAANDVLEWLD DNFETAIAEDFDEKFESLSKVAYPITSKLYGGADGSGAADYDDEDEDDDGDYFEHDEL " gene 383837..386149 /gene="HCA4" /locus_tag="YJL033W" /gene_synonym="DBP4" /gene_synonym="ECM24" mRNA 383837..386149 /gene="HCA4" /locus_tag="YJL033W" /gene_synonym="DBP4" /gene_synonym="ECM24" /product="RNA-dependent ATPase HCA4" CDS 383837..386149 /gene="HCA4" /locus_tag="YJL033W" /gene_synonym="DBP4" /gene_synonym="ECM24" /EC_number="3.6.4.13" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:23153376]" /experiment="EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:18975973|PMID:23153376]" /experiment="EXISTENCE:mutant phenotype:GO:0003724 RNA helicase activity [PMID:16209945]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:16209945]" /experiment="EXISTENCE:mutant phenotype:GO:0032040 small-subunit processome [PMID:24357410]" /note="DEAD box RNA helicase; component of the SSU; interacts with Bfr2p and Enp2p; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis" /codon_start=1 /product="RNA-dependent ATPase HCA4" /protein_id="DAA08766.1" /db_xref="SGD:S000003570" /translation="MAKKNRLNTTQRKTLRQKEDEYIENLKTKIDEYDPKITKAKFFK DLPISDPTLKGLRESSFIKLTEIQADSIPVSLQGHDVLAAAKTGSGKTLAFLVPVIEK LYREKWTEFDGLGALIISPTRELAMQIYEVLTKIGSHTSFSAGLVIGGKDVKFELERI SRINILIGTPGRILQHLDQAVGLNTSNLQMLVLDEADRCLDMGFKKTLDAIVSTLSPS RQTLLFSATQSQSVADLARLSLTDYKTVGTHDVMDGSVNKEASTPETLQQFYIEVPLA DKLDILFSFIKSHLKCKMIVFLSSSKQVHFVYETFRKMQPGISLMHLHGRQKQRARTE TLDKFNRAQQVCLFATDVVARGIDFPAVDWVVQVDCPEDVDTYIHRVGRCARYGKKGK SLIMLTPQEQEAFLKRLNARKIEPGKLNIKQSKKKSIKPQLQSLLFKDPELKYLGQKA FISYVRSIYVQKDKQVFKFDELPTEEFAYSLGLPGAPKIKMKGMKTIEQAKERKNAPR QLAFLSKANEDGEVIEDKSKQPRTKYDKMFERKNQTILSEHYLNITKAQAQEDEDDDF ISVKRKDHEINEAELPALTLPTSRRAQKKALSKKASLASKGNASKLIFDDEGEAHPVY ELEDEEEFHKRGDAEVQKTEFLTKESAVMADIDNIDKQVAKEKKQEKKRKRLEAMRRE MEAAMEEEISGDEEEGKTVAYLGTGNLSDDMSDGDMPDSEGHLKKKARTVDYSHGHNP SNSVDDDIIEVEEPQTLEDLESLTAKLIQG" gene complement(386368..387438) /gene="BET4" /locus_tag="YJL031C" mRNA complement(join(386368..387348,387436..387438)) /gene="BET4" /locus_tag="YJL031C" /product="Rab geranylgeranyltransferase BET4" CDS complement(join(386368..387348,387436..387438)) /gene="BET4" /locus_tag="YJL031C" /EC_number="2.5.1.60" /experiment="EXISTENCE:direct assay:GO:0004663 Rab geranylgeranyltransferase activity [PMID:8756702]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:27663510]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005968 Rab-protein geranylgeranyltransferase complex [PMID:8756702]" /experiment="EXISTENCE:direct assay:GO:0018344 protein geranylgeranylation [PMID:8756702]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:8232541]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:8232541]" /experiment="EXISTENCE:mutant phenotype:GO:0018344 protein geranylgeranylation [PMID:8232541]" /experiment="EXISTENCE:physical interaction:GO:0005968 Rab-protein geranylgeranyltransferase complex [PMID:8232542]" /note="Alpha subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p" /codon_start=1 /product="Rab geranylgeranyltransferase BET4" /protein_id="DAA08767.1" /db_xref="SGD:S000003568" /translation="MHGIKRKQWTKELLRQKRVQDEKKIYDYRSLTENVLNMRDEKIY SIEALKKTSELLEKNPEFNAIWNYRRDIIASLASELEIPFWDKELVFVMMLLKDYPKV YWIWNHRLWVLKHYPTSSPKVWQTELAVVNKLLEQDARNYHGWHYRRIVVGNIESITN KSLDKEEFEYTTIKINNNISNYSAWHQRVQIISRMFQKGEVGNQKEYIRTEISYIINA MFTDAEDQSVWFYIKWFIKNDIVCKTLDEQEYLKMLKDLRENILLINNDEIEFSGKQN IWCLKILLVLEDILEEKEALTERSSEQYLVQLIDADPLRKNRYLHLLEQHK" gene 387657..388247 /gene="MAD2" /locus_tag="YJL030W" mRNA 387657..388247 /gene="MAD2" /locus_tag="YJL030W" /product="spindle checkpoint protein MAD2" CDS 387657..388247 /gene="MAD2" /locus_tag="YJL030W" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:27170178]" /experiment="EXISTENCE:direct assay:GO:0033597 mitotic checkpoint complex [PMID:11726501]" /experiment="EXISTENCE:direct assay:GO:1902499 positive regulation of protein autoubiquitination [PMID:22940250]" /experiment="EXISTENCE:genetic interaction:GO:0044774 mitotic DNA integrity checkpoint signaling [PMID:16651657]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:10704439]" /experiment="EXISTENCE:physical interaction:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:9461437]" /experiment="EXISTENCE:physical interaction:GO:0033597 mitotic checkpoint complex [PMID:10704439|PMID:11726501]" /note="Component of the spindle-assembly checkpoint complex; delays onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability" /codon_start=1 /product="spindle checkpoint protein MAD2" /protein_id="DAA08768.1" /db_xref="SGD:S000003567" /translation="MSQSISLKGSTRTVTEFFEYSINSILYQRGVYPAEDFVTVKKYD LTLLKTHDDELKDYIRKILLQVHRWLLGGKCNQLVLCIVDKDEGEVVERWSFNVQHIS GNSNGQDDVVDLNTTQSQIRALIRQITSSVTFLPELTKEGGYTFTVLAYTDADAKVPL EWADSNSKEIPDGEVVQFKTFSTNDHKVGAQVSYKY" gene complement(388385..390853) /gene="VPS53" /locus_tag="YJL029C" mRNA complement(388385..390853) /gene="VPS53" /locus_tag="YJL029C" /product="Vps53p" CDS complement(388385..390853) /gene="VPS53" /locus_tag="YJL029C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:10637310]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0042147 retrograde transport, endosome to Golgi [PMID:12686613]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:10637310]" /experiment="EXISTENCE:mutant phenotype:GO:0090156 intracellular sphingolipid homeostasis [PMID:26357016]" /experiment="EXISTENCE:physical interaction:GO:0000938 GARP complex [PMID:10637310]" /note="Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; required for vacuolar protein sorting; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p; human ortholog is implicated in progressive cerebello-cerebral atrophy type 2 (PCCA2)" /codon_start=1 /product="Vps53p" /protein_id="DAA08769.1" /db_xref="SGD:S000003566" /translation="MLEGTVDYDPLEDITNILFSKESLNNIDELISITRSYKKQLQED ILKEENELKEHPKNSAEIEASLRKVFQDFKETQDVSASTELTISNLTEGISYLDIAKK NLTHSLTLFQNLKILTDSYIQCNELLSQGSFKKMVSPYKIMCSLAENTFISYKSLDEI NYLLSSISRLKGDTLSKIKQNYNALFSGGNISEHDTALTMELREGACELLDCDTSTRA QMIDWCLDKLLFEMKEIFRVDDEAGSLENLSRRYIYFKKILNNFNSKFADYFLKDWEM AVRLTTTFYHITHKDLQTLLKREFKDKNPSIDLFMTALQSTLDFEKYIDVRFSKKIKE PKLSSCFEPYLTLWVSHQNQMMEKKFLSYMSEPKYPSNETESLVLPSSADLFRTYRSV LTQTLELIDNNANDSILTSLANFFSRWLQTYSQKILLPLLLPDNIEVQDKLEAAKYTV LLINTADYCATTIDQLEDKLSEFSGNREKLANSFTKTKNIYDDLLAKGTSFLLNRVIP LDLNFVWREFINNDWSNAAIEDYSRYMVTLKSVLKMPALTDASIKQQQEQPSTLAFIL SQFNRDVYKWNFLDKVIDIITTNFVSNTIRLLQPVPPFSLAGSKRKFETRTVVNIGEQ LLLDLELLKEIFHTLPESVSNDSDLRENTSYKRVKRHADNNIDQLLKFIKLLMAPLDS ADDYYETYSKLTNNNPDSAVWSFVLALKGIPWDLALWKKLWSAYNLETDDTDEGSRPD SNRDLFIFKWDKVLLGQFENNLARMQDPNWSKFVRQDLKISPPVMKRIVSTPQIQQQK EEQKKQSLSVKDFVSHSRFFNRGT" gene complement(391043..391115) /gene="EMT5" /locus_tag="YNCJ0016C" tRNA complement(391043..391115) /gene="EMT5" /locus_tag="YNCJ0016C" /product="tRNA-Met" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Methionine tRNA (tRNA-Met), functions in translational elongation; not involved in translational initiation; predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006661" gene 391311..391646 /locus_tag="YJL028W" mRNA 391311..391646 /locus_tag="YJL028W" /product="hypothetical protein" CDS 391311..391646 /locus_tag="YJL028W" /note="hypothetical protein; may interact with ribosomes, based on co-purification experiments" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08770.1" /db_xref="SGD:S000003565" /translation="MALWGRSAYRQKTVTSRLTKHRHTSPLNLLNFFIFFSLHLCALF LATAVHYACFACFVLFRHAILLLFYLLARGRASQIQARQKVRCTGATFYRFLIISLSQ RAWATKKPI" gene complement(391833..392249) /locus_tag="YJL027C" mRNA complement(391833..392249) /locus_tag="YJL027C" /product="hypothetical protein" CDS complement(391833..392249) /locus_tag="YJL027C" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08771.1" /db_xref="SGD:S000003564" /translation="MMVTRKHYRYIYLQNSHSLISCFVHFEFPRVWYGAICPCFPSFA LLRKIFFCQQQQHATLCAVLRSGLCGNGDIVPMPARREVWVWGVCDLVAMAIARGCGL SPNGCPLLRISHSCRVNKKHERGRTALNSGRSRDVK" gene 392404..393603 /gene="RNR2" /locus_tag="YJL026W" /gene_synonym="CRT6" mRNA 392404..393603 /gene="RNR2" /locus_tag="YJL026W" /gene_synonym="CRT6" /product="ribonucleotide-diphosphate reductase subunit RNR2" CDS 392404..393603 /gene="RNR2" /locus_tag="YJL026W" /gene_synonym="CRT6" /EC_number="1.17.4.1" /experiment="EXISTENCE:direct assay:GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [PMID:10716984|PMID:10535923]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12732713]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9315670|PMID:12732713]" /experiment="EXISTENCE:direct assay:GO:0005971 ribonucleoside-diphosphate reductase complex [PMID:10716984]" /experiment="EXISTENCE:direct assay:GO:0009263 deoxyribonucleotide biosynthetic process [PMID:10535923|PMID:5459124]" /note="Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; RNR2 has a paralog, RNR4, that arose from the whole genome duplication" /codon_start=1 /product="ribonucleotide-diphosphate reductase subunit RNR2" /protein_id="DAA08772.1" /db_xref="SGD:S000003563" /translation="MPKETPSKAAADALSDLEIKDSKSNLNKELETLREENRVKSDML KEKLSKDAENHKAYLKSHQVHRHKLKEMEKEEPLLNEDKERTVLFPIKYHEIWQAYKR AEASFWTAEEIDLSKDIHDWNNRMNENERFFISRVLAFFAASDGIVNENLVENFSTEV QIPEAKSFYGFQIMIENIHSETYSLLIDTYIKDPKESEFLFNAIHTIPEIGEKAEWAL RWIQDADALFGERLVAFASIEGVFFSGSFASIFWLKKRGMMPGLTFSNELICRDEGLH TDFACLLFAHLKNKPDPAIVEKIVTEAVEIEQRYFLDALPVALLGMNADLMNQYVEFV ADRLLVAFGNKKYYKVENPFDFMENISLAGKTNFFEKRVSDYQKAGVMSKSTKQEAGA FTFNEDF" gene 393967..395511 /gene="RRN7" /locus_tag="YJL025W" mRNA 393967..395511 /gene="RRN7" /locus_tag="YJL025W" /product="Rrn7p" CDS 393967..395511 /gene="RRN7" /locus_tag="YJL025W" /experiment="EXISTENCE:direct assay:GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding [PMID:18451108]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22362748]" /experiment="EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:8702872]" /experiment="EXISTENCE:direct assay:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:7958901]" /experiment="EXISTENCE:direct assay:GO:0070860 RNA polymerase I core factor complex [PMID:7958901|PMID:8702872|PMID:8887672]" /experiment="EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:7958901]" /experiment="EXISTENCE:physical interaction:GO:0017025 TBP-class protein binding [PMID:8702872]" /note="Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p" /codon_start=1 /product="Rrn7p" /protein_id="DAA08773.1" /db_xref="SGD:S000003562" /translation="MSTFIRGPICGTDNCPSRLWRIIDGRRTCQYGHVMEGDVEFNDD EDDLNGLGAGVITRRLNLTTNATGSFQSSQLTNSQLLQQQQRQSHKKFKKLIGHEAKL LFLKSFQFILKRQIRWLITEMRFPKEFEHVAKIIWLKILKTINDQPQEELKLQLHMTS TISILYLASTHLSLPVYTCDYIKWICTAKMPYFQASEILPKSWRIQLPNYYVSILEGS ISPFNGQLYNKIALTCGMIHFKEFFNSEISCQGLLLKLVMQCALPPEFYFYTKQVIEF EETDIRNLTLWERTDERHTGRVSNHAELRVLSYFMLTINWMLSFDRDRQYPLKWILSL TESLTQRTTTSESIGRNIVKVVYPDKPTSSDYFQWSEEETLEFLKWMEKQFLPTQTKS LHNENGSMEMTIDQKIARRKLYKIFPLDREANHDGEFNDSTHQLTFIEDLQERYAKQT PFFESNKIRDSLNYQEANPPARKEAIGRLLTHIASQLLVDFAISKEQLKDCISRIKNA CLHRMN" gene complement(395931..396592) /gene="APS3" /locus_tag="YJL024C" /gene_synonym="YKS7" mRNA complement(join(395931..396493,396571..396592)) /gene="APS3" /locus_tag="YJL024C" /gene_synonym="YKS7" /product="Aps3p" CDS complement(join(395931..396493,396571..396592)) /gene="APS3" /locus_tag="YJL024C" /gene_synonym="YKS7" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:17895371]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:9335339]" /experiment="EXISTENCE:mutant phenotype:GO:0030123 AP-3 adaptor complex [PMID:9250663]" /note="Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="Aps3p" /protein_id="DAA08774.1" /db_xref="SGD:S000003561" /translation="MIHAVLIFNKKCQPRLVKFYTPVDLPKQKLLLEQVYELISQRNS DFQSSFLVTPPSLLLSNENNNDEVNNEDIQIIYKNYATLYFTFIVDDQESELAILDLI QTFVESLDRCFTEVNELDLIFNWQTLESVLEEIVQGGMVIETNVNRIVASVDELNKAA ESTDSKIGRLTSTGFGSALQAFAQGGFAQWATGQ" gene complement(396726..396796) /locus_tag="YNCJ0017C" tRNA complement(396726..396796) /locus_tag="YNCJ0017C" /product="tRNA-Gly" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /experiment="EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]" /experiment="EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]" /note="Glycine tRNA (tRNA-Gly), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006583" gene complement(397355..398398) /gene="PET130" /locus_tag="YJL023C" mRNA complement(397355..398398) /gene="PET130" /locus_tag="YJL023C" /product="Pet130p" CDS complement(397355..398398) /gene="PET130" /locus_tag="YJL023C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0099617 matrix side of mitochondrial inner membrane [PMID:30759361]" /experiment="EXISTENCE:mutant phenotype:GO:0097745 mitochondrial tRNA 5'-end processing [PMID:30759361]" /note="hypothetical protein; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; localizes to the matrix side of the inner mitochondrial membrane" /codon_start=1 /product="Pet130p" /protein_id="DAA08775.1" /db_xref="SGD:S000003560" /translation="MKIFSTLLSQKPKGKLVIRPSTTIHSSDPFSKFIVTKNTEPLSL GDLRKSDSGNSAVCLNAENTILSTLTDLQKEEERNWDPVKFVAGKLRGVISPIQAYVT IGKKFSPNSLVYTSRFFQLHYFPEDHFMSCFRKSKPAITVKSNKKFYLNGKVFNKDKE YFNETRISKANEVELSKIQTAMTRLTNRHRNSIPSEFAYLRRDLKLKVKTTFIKEWCK LNGDKAIREYVNLNRSPNINPASMKGKPKKSFLDNLGRSTVGTAKDGYYLYIVSIFPD KDMLGEFNDEVNRSVQKVANLDWDGFLTPKKGTKGKNWVESFNDSINVQTINKILEIN KFPFELRREQTEG" gene complement(398937..402410) /gene="BBC1" /locus_tag="YJL020C" /gene_synonym="MTI1" /gene_synonym="YJL021C" mRNA complement(398937..402410) /gene="BBC1" /locus_tag="YJL020C" /gene_synonym="MTI1" /gene_synonym="YJL021C" /product="Bbc1p" CDS complement(398937..402410) /gene="BBC1" /locus_tag="YJL020C" /gene_synonym="MTI1" /gene_synonym="YJL021C" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:16824951|PMID:11743162]" /experiment="EXISTENCE:direct assay:GO:0032032 myosin I tail binding [PMID:11901111]" /experiment="EXISTENCE:direct assay:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:12814545]" /experiment="EXISTENCE:genetic interaction:GO:0030036 actin cytoskeleton organization [PMID:11901111]" /experiment="EXISTENCE:physical interaction:GO:0032032 myosin I tail binding [PMID:11901111]" /note="Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches" /codon_start=1 /product="Bbc1p" /protein_id="DAA08776.1" /db_xref="SGD:S000003557" /translation="MSEPEVPFKVVAQFPYKSDYEDDLNFEKDQEIIVTSVEDAEWYF GEYQDSNGDVIEGIFPKSFVAVQGSEVGKEAESSPNTGSTEQRTIQPEVEQKDLPEPI SPETKKETLSGPVPVPAATVPVPAATVPVPAATAVSAQVQHDSSSGNGERKVPMDSPK LKARLSMFNQDITEQVPLPKSTHLDLENIPVKKTIVADAPKYYVPPGIPTNDTSNLER KKSLKENEKKIVPEPINRAQVESGRIETENDQLKKDLPQMSLKERIALLQEQQRLQAA REEELLRKKAKLEQEHERSAVNKNEPYTETEEAEENEKTEPKPEFTPETEHNEEPQME LLAHKEITKTSREADEGTNDIEKEQFLDEYTKENQKVEESQADEARGENVAEESEIGY GHEDREGDNDEEKEEEDSEENRRAALRERMAKLSGASRFGAPVGFNPFGMASGVGNKP SEEPKKKQHKEKEEEEPEQLQELPRAIPVMPFVDPSSNPFFRKSNLSEKNQPTETKTL DPHATTEHEQKQEHGTHAYHNLAAVDNAHPEYSDHDSDEDTDDHEFEDANDGLRKHSM VEQAFQIGNNESENVNSGEKIYPQEPPISHRTAEVSHDIENSSQNTTGNVLPVSSPQT RVARNGSINSLTKSISGENRRKSINEYHDTVSTNSSALTETAQDISMAAPAAPVLSKV SHPEDKVPPHPVPSAPSAPPVPSAPSVPSAPPVPPAPPALSAPSVPPVPPVPPVSSAP PALSAPSIPPVPPTPPAPPAPPAPLALPKHNEVEEHVKSSAPLPPVSEEYHPMPNTAP PLPRAPPVPPATFEFDSEPTATHSHTAPSPPPHQNVTASTPSMMSTQQRVPTSVLSGA EKESRTLPPHVPSLTNRPVDSFHESDTTPKVASIRRSTTHDVGEISNNVKIEFNAQER WWINKSAPPAISNLKLNFLMEIDDHFISKRLHQKWVVRDFYFLFENYSQLRFSLTFNS TSPEKTVTTLQERFPSPVETQSARILDEYAQRFNAKVVEKSHSLINSHIGAKNFVSQI VSEFKDEVIQPIGARTFGATILSYKPEEGIEQLMKSLQKIKPGDILVIRKAKFEAHKK IGKNEIINVGMDSAAPYSSVVTDYDFTKNKFRVIENHEGKIIQNSYKLSHMKSGKLKV FRIVARGYVGW" gene 402897..404945 /gene="MPS3" /locus_tag="YJL019W" /gene_synonym="NEP98" /gene_synonym="YJL018W" mRNA 402897..404945 /gene="MPS3" /locus_tag="YJL019W" /gene_synonym="NEP98" /gene_synonym="YJL018W" /product="Mps3p" CDS 402897..404945 /gene="MPS3" /locus_tag="YJL019W" /gene_synonym="NEP98" /gene_synonym="YJL018W" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:17495028]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:17495028]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:16923827]" /experiment="EXISTENCE:direct assay:GO:0005825 half bridge of spindle pole body [PMID:12486115]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:12493774|PMID:12486115]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:18039933|PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0007129 homologous chromosome pairing at meiosis [PMID:17495028]" /experiment="EXISTENCE:genetic interaction:GO:0045141 meiotic telomere clustering [PMID:17495028]" /experiment="EXISTENCE:mutant phenotype:GO:0000741 karyogamy [PMID:16923827]" /experiment="EXISTENCE:mutant phenotype:GO:0000743 nuclear migration involved in conjugation with cellular fusion [PMID:12493774]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:15355977]" /experiment="EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:17495028]" /experiment="EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:16923827|PMID:12486115]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:22593213]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:22593213]" /experiment="EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:18039933|PMID:22593213]" /experiment="EXISTENCE:mutant phenotype:GO:0045141 meiotic telomere clustering [PMID:17495028]" /note="Nuclear envelope protein; required for SPB insertion, SPB duplication, Kar5p localization near the SPB and nuclear fusion; interacts with Mps2p to tether half-bridge to core SPB; N-terminal acetylation by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; member of the SUN protein family (Sad1-UNC-84 homology)" /codon_start=1 /product="Mps3p" /protein_id="DAA08777.1" /db_xref="SGD:S000003556" /translation="MNNSNEHRREEAGAANEQMPYNKAVKSAYADVLKDKMNREQEIS LRAIKKGIYTDGGETDNYDMDKENDSAYEMFKKNLDFPLDQHNDDDDDDPYIEDNGQE TDGYSDEDYTDEADKSFIEDSDSDSYDLESNSDFEENLESSGEAKKLKWRTYIFYGGL FFVFYFFGSFLMTTVKNNDLESHSSGATSSPGKSFSNLQKQVNHLYSELSKRDEKHSS ELDKTVKIIVSQFEKNIKRLLPSNLVNFENDINSLTKQVETISTSMSELQRRNHKFTV ENVTQWQDQLVKQLDTHLPQEIPVVINNSSSLLIIPELHNYLSALISDVIESPGIGTA GSAESRWEYDLNRYVKEILSNELQYIDKDYFIQEMNRRLQSNKQEIWEEITNRLETQQ QQQQQQVQQDYSNVPQQYSSILMKRLIHQIYNSNQHQWEDDLDFATYVQGTKLLNHLT SPTWRQGSGVQPIELLTDSKQSSSTYWQCENEPGCSWAIRFKTPLYLTKISYMHGRFT NNLHIMNSAPRLISLYVKLSQTKEIKALQTLANQYGFGQHHKRDRNYIKIAKFEYRLT DSRIRQQMYLPPWFIQLKPLVRSIVFQVDENYGNKKFISLRKFIINGVTPQDLQIIEN NEFPVLLGDTPEYGVTQNTDEGKRKVLLSKPPYASSSTSTKFHPASNVPSFGQDELDQ " gene 405588..407273 /gene="TPH3" /locus_tag="YJL016W" /gene_synonym="YJL017W" mRNA 405588..407273 /gene="TPH3" /locus_tag="YJL016W" /gene_synonym="YJL017W" /product="Tph3p" CDS 405588..407273 /gene="TPH3" /locus_tag="YJL016W" /gene_synonym="YJL017W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; GFP-fusion protein localizes to the cytoplasm; contains two adjacent PH-like domains; conserved in closely related Saccharomyces species" /codon_start=1 /product="Tph3p" /protein_id="DAA08778.1" /db_xref="SGD:S000003553" /translation="MGILDSLKKPVNIKSSLPKFSRSATSINLSSHPVSSRSFLELPP ELFSITKPIFKLLQAHANKIYFQSSDAEAVWNVKDSSGHVFEAESISLLGSHIIITNS SVQVADVAIIDSPSNINQCEISSVGEFLQFNNGQLSITCNDFGLLEKFKRLCMISIFE FISIYKALTGTVISSYGLRMSDMHIILNSPFNFKDWCEVYLDGQGWVKVWCHIDKVSK TNNSKSSSDNDAKGKYQIRFYRDDKSTSSKNCVFFIPDNEYVQDIFFYNINAAEPSKN MNDFFQGLQMIKLVGNVRFCSDTDFNDVVDSGSIYSSANNGSGDSSSTALNNESPNTT PKSRTFFSPKGHRRNSSHVSSLTSRSTKKPITNFTTRTNGLLIRPLPHHGVHHLEAMI RFIIPLMDCARLYGRPVQFKTERTDINSLMFGLPKLPSVDYFAEEEIAHLMTQEFNPL KEKDTDDTMALTMSRFSSYLQERMTKVSKRNTELNFRTFSDVMGMYNTTRDHSKLNCM SDKDNSVKEFSLSDKSNVSSETTNMMNQLQVNAHEYKSSMCERPIVASTSPIA" gene 407558..409162 /gene="CCT3" /locus_tag="YJL014W" /gene_synonym="BIN2" /gene_synonym="TCP3" mRNA 407558..409162 /gene="CCT3" /locus_tag="YJL014W" /gene_synonym="BIN2" /gene_synonym="TCP3" /product="chaperonin-containing T-complex subunit CCT3" CDS 407558..409162 /gene="CCT3" /locus_tag="YJL014W" /gene_synonym="BIN2" /gene_synonym="TCP3" /experiment="EXISTENCE:direct assay:GO:0005832 chaperonin-containing T-complex [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16762366]" /experiment="EXISTENCE:physical interaction:GO:0005832 chaperonin-containing T-complex [PMID:15704212]" /note="Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; capable of binding Q/N rich proteins and mediating their folding" /codon_start=1 /product="chaperonin-containing T-complex subunit CCT3" /protein_id="DAA08779.1" /db_xref="SGD:S000003551" /translation="MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAM LKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGE ILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIG TKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSR VLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIE EEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGA TIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEI DRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAME CIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQ SVKTAIESACLLLRVDDIVSGVRKQE" gene complement(409493..411040) /gene="MAD3" /locus_tag="YJL013C" mRNA complement(409493..411040) /gene="MAD3" /locus_tag="YJL013C" /product="Mad3p" CDS complement(409493..411040) /gene="MAD3" /locus_tag="YJL013C" /experiment="EXISTENCE:direct assay:GO:0033597 mitotic checkpoint complex [PMID:11726501]" /experiment="EXISTENCE:direct assay:GO:1902499 positive regulation of protein autoubiquitination [PMID:22940250]" /experiment="EXISTENCE:genetic interaction:GO:0044774 mitotic DNA integrity checkpoint signaling [PMID:16651657]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:10704439]" /experiment="EXISTENCE:mutant phenotype:GO:0032837 distributive segregation [PMID:15951820]" /experiment="EXISTENCE:mutant phenotype:GO:0033597 mitotic checkpoint complex [PMID:10704439]" /experiment="EXISTENCE:physical interaction:GO:0033597 mitotic checkpoint complex [PMID:10704439|PMID:11726501]" /note="Subunit of spindle-assembly checkpoint complex; involved in delaying anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover; MAD3 has a paralog, BUB1, that arose from the whole genome duplication" /codon_start=1 /product="Mad3p" /protein_id="DAA08780.1" /db_xref="SGD:S000003550" /translation="MKAYAKKRISYMPSSPSQNVINFEEIETQKENILPLKEGRSAAA LSKAIHQPLVEINQVKSSFEQRLIDELPALSDPITLYLEYIKWLNNAYPQGGNSKQSG MLTLLERCLSHLKDLERYRNDVRFLKIWFWYIELFTRNSFMESRDIFMYMLRNGIGSE LASFYEEFTNLLIQKEKFQYAVKILQLGIKNKARPNKVLEDRLNHLLRELGENNIQLG NEISMDSLESTVLGKTRSEFVNRLELANQNGTSSDVNLTKNNVFVDGEESDVELFETP NRGVYRDGWENFDLKAERNKENNLRISLLEANTNLGELKQHEMLSQKKRPYDEKLPIF RDSIGRSDPVYQMINTKDQKPEKIDCNFKLIYCEDEESKGGRLEFSLEEVLAISRNVY KRVRTNRKHPREANLGQEESANQKEAEAQSKRPKISRKALVSKSLTPSNQGRMFSGEE YINCPMTPKGRSTETSDIISAVKPRQLTPILEMRESNSFSQSKNSEIISDDDKSSSSF ISYPPQR" gene complement(411234..413399) /gene="VTC4" /locus_tag="YJL012C" /gene_synonym="PHM3" /gene_synonym="YJL012C-A" mRNA complement(411234..413399) /gene="VTC4" /locus_tag="YJL012C" /gene_synonym="PHM3" /gene_synonym="YJL012C-A" /product="Vtc4p" CDS complement(411234..413399) /gene="VTC4" /locus_tag="YJL012C" /gene_synonym="PHM3" /gene_synonym="YJL012C-A" /EC_number="2.7.4.1" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000822 inositol hexakisphosphate binding [PMID:27080106]" /experiment="EXISTENCE:direct assay:GO:0005516 calmodulin binding [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:12584253]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0007034 vacuolar transport [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0008976 polyphosphate kinase activity [PMID:19390046]" /experiment="EXISTENCE:direct assay:GO:0016237 microautophagy [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006797 polyphosphate metabolic process [PMID:11102525|PMID:19390046]" /experiment="EXISTENCE:mutant phenotype:GO:0006799 polyphosphate biosynthetic process [PMID:27252384|PMID:27080106]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:17079729]" /experiment="EXISTENCE:mutant phenotype:GO:0016237 microautophagy [PMID:17079729]" /experiment="EXISTENCE:physical interaction:GO:0033254 vacuolar transporter chaperone complex [PMID:11823419]" /note="Vacuolar membrane polyphosphate polymerase; subunit of vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="Vtc4p" /protein_id="DAA08781.1" /db_xref="SGD:S000003549" /translation="MKFGEHLSKSLIRQYSYYYISYDDLKTELEDNLSKNNGQWTQEL ETDFLESLEIELDKVYTFCKVKHSEVFRRVKEVQEQVQHTVRLLDSNNPPTQLDFEIL EEELSDIIADVHDLAKFSRLNYTGFQKIIKKHDKKTGFILKPVFQVRLDSKPFFKENY DELVVKISQLYDIARTSGRPIKGDSSAGGKQQNFVRQTTKYWVHPDNITELKLIILKH LPVLVFNTNKEFEREDSAITSIYFDNENLDLYYGRLRKDEGAEAHRLRWYGGMSTDTI FVERKTHREDWTGEKSVKARFALKERHVNDFLKGKYTVDQVFAKMRKEGKKPMNEIEN LEALASEIQYVMLKKKLRPVVRSFYNRTAFQLPGDARVRISLDTELTMVREDNFDGVD RTHKNWRRTDIGVDWPFKQLDDKDICRFPYAVLEVKLQTQLGQEPPEWVRELVGSHLV EPVPKFSKFIHGVATLLNDKVDSIPFWLPQMDVDIRKPPLPTNIEITRPGRSDNEDND FDEDDEDDAALVAAMTNAPGNSLDIEESVGYGATSAPTSNTNHVVESANAAYYQRKIR NAENPISKKYYEIVAFFDHYFNGDQISKIPKGTTFDTQIRAPPGKTICVPVRVEPKVY FATERTYLSWLSISILLGGVSTTLLTYGSPTAMIGSIGFFITSLAVLIRTVMVYAKRV VNIRLKRAVDYEDKIGPGMVSVFLILSILFSFFCNLVAK" gene complement(414285..414770) /gene="RPC17" /locus_tag="YJL011C" mRNA complement(414285..414770) /gene="RPC17" /locus_tag="YJL011C" /product="DNA-directed RNA polymerase III subunit RPC17" CDS complement(414285..414770) /gene="RPC17" /locus_tag="YJL011C" /experiment="EXISTENCE:direct assay:GO:0001056 RNA polymerase III activity [PMID:10611227|PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:10611227]" /experiment="EXISTENCE:physical interaction:GO:0006384 transcription initiation at RNA polymerase III promoter [PMID:10611227]" /note="RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia" /codon_start=1 /product="DNA-directed RNA polymerase III subunit RPC17" /protein_id="DAA08782.2" /db_xref="SGD:S000003548" /translation="MKVLEERNAFLSDYEVLKFLTDLEKKHLWDQKSLAALKKSRSKG KQNRPYNHPELQGITRNVVNYLSINKNFINQEDEGEERESSGAKDAEKSGISKMSDES FAELMTKLNSFKLFKAEKLQIVNQLPANMVHLYSIVEECDARFDEKTIEEMLEIISGY A" gene 414966..415038 /locus_tag="YNCJ0018W" tRNA 414966..415038 /locus_tag="YNCJ0018W" /product="tRNA-Lys" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:8915539]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:8915539]" /experiment="EXISTENCE:mutant phenotype:GO:0030533 triplet codon-amino acid adaptor activity [PMID:17560369]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:17560369]" /note="Lysine tRNA (tRNA-Lys), predicted by tRNAscan-SE analysis; a small portion is imported into mitochondria via interaction with mt lysyl-tRNA synthetase Msk1p and is necessary to decode AAG codons at high temperature, when base modification of mt-encoded tRNA-Lys is reduced" /db_xref="SGD:S000006625" gene complement(415931..416036) /locus_tag="YNCJ0019C" tRNA complement(join(415931..415966,416001..416036)) /locus_tag="YNCJ0019C" /product="tRNA-Trp" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Tryptophan tRNA (tRNA-Trp), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006773" repeat_region 416266..416441 /note="Ty4 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007047" repeat_region 416506..416650 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007029" repeat_region 416899..417026 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007030" rep_origin 417195..417440 /note="ARS1014; Autonomously Replicating Sequence" /db_xref="SGD:S000028451" gene complement(417562..419562) /gene="NOP9" /locus_tag="YJL010C" mRNA complement(417562..419562) /gene="NOP9" /locus_tag="YJL010C" /product="RNA-binding RNA processing protein NOP9" CDS complement(417562..419562) /gene="NOP9" /locus_tag="YJL010C" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:17956976]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095|PMID:17956976|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:17956976]" /experiment="EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:17956976]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:17956976]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17956976]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17956976]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17956976]" /note="Essential subunit of U3-containing 90S preribosome; involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain" /codon_start=1 /product="RNA-binding RNA processing protein NOP9" /protein_id="DAA08783.1" /db_xref="SGD:S000003547" /translation="MGKTKTRGRRHQDKQRKDEFEPSSNSAKEHIQQEESTYNDEAEI KETQPQMFFGVLDREELEYFKQAESTLQLDAFEAPEEKFQFVTSIIEEAKGKELKLVT SQITSKLMERVILECDETQLKDIFQSFNGVFFGLSCHKYASHVLETLFVRSAALVERE LLTPSFDNNEKEGPYVTMENMFLFMLNELKPHLKTMMNHQYASHVLRLLILILSSKTL PNSTKANSTLRSKKSKIARKMIDIKDNDDFNKVYQTPESFKSELRDIITTLYKGFTNG AESRSDISQSTITKFREYSVDKVASPVIQLIIQVEGIFDRDRSFWRLVFNTADEKDPK EESFLEYLLSDPVGSHFLENVIGSARLKYVERLYRLYMKDRIVKLAKRDTTGAFVVRA LLEHLKEKDVKQILDAVVPELSMLLNSNMDFGTAIINASNKQGGYLRDDVIAQLIQKY YPEKSDAKNILESCLLLSASTLGNTRDDWPTAEERRRSVFLEQLIDYDDKFLNITIDS MLALPEERLIQMCYHGVFSHVVEHVLQTTRVDIIKRKMLLNILSKESVNLACNVYGSH IMDKLWEFTAKLTLYKERIARALVLETEKVKNSIYGRQVWKNWKLELYVRKMWDWKKL IKEQEFEIFPNSKPLQPKPEKHSRERNNSKEGSAFKKQKHYR" gene complement(419957..421663) /gene="CCT8" /locus_tag="YJL008C" mRNA complement(419957..421663) /gene="CCT8" /locus_tag="YJL008C" /product="chaperonin-containing T-complex subunit CCT8" CDS complement(419957..421663) /gene="CCT8" /locus_tag="YJL008C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005832 chaperonin-containing T-complex [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16762366]" /experiment="EXISTENCE:physical interaction:GO:0005832 chaperonin-containing T-complex [PMID:15704212]" /note="Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo" /codon_start=1 /product="chaperonin-containing T-complex subunit CCT8" /protein_id="DAA08784.1" /db_xref="SGD:S000003545" /translation="MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLT SMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNL VMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELL KMIKPVISSKKYGSEDILSELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLS NSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDF SKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCR VCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQN NLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIK QFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEG VKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMAKKAGGPRAPQGPRPGNWDQ ED" repeat_region 421946..422295 /note="Ty4 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007038" repeat_region 422601..422887 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007031" gene complement(422698..423012) /locus_tag="YJL007C" mRNA complement(422698..423012) /locus_tag="YJL007C" /product="hypothetical protein" CDS complement(422698..423012) /locus_tag="YJL007C" /note="hypothetical protein; conserved among S. cerevisiae strains" /codon_start=1 /product="hypothetical protein" /protein_id="DAA80307.1" /db_xref="SGD:S000003544" /translation="MCSRGGSNSRPSDYETDALPTELLKHTKDVGEEKQTLHQIFADS MVIKGYSTGYTGHTRSSPGDLVIHKRELIFSHNIVIIVSPIYMISFIILLHYQSWHFS IY" gene 422937..423009 /gene="EMT3" /locus_tag="YNCJ0020W" tRNA 422937..423009 /gene="EMT3" /locus_tag="YNCJ0020W" /product="tRNA-Met" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Methionine tRNA (tRNA-Met), functions in translational elongation; not involved in translational initiation; predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006662" gene complement(423138..424109) /gene="CTK2" /locus_tag="YJL006C" mRNA complement(423138..424109) /gene="CTK2" /locus_tag="YJL006C" /product="Ctk2p" CDS complement(423138..424109) /gene="CTK2" /locus_tag="YJL006C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15520468]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15520468]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:11118453]" /experiment="EXISTENCE:direct assay:GO:0032786 positive regulation of DNA-templated transcription, elongation [PMID:9110987]" /experiment="EXISTENCE:direct assay:GO:0070692 CTDK-1 complex [PMID:7565723]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:15520468]" /experiment="EXISTENCE:physical interaction:GO:0045903 positive regulation of translational fidelity [PMID:17545469]" /note="Beta subunit of C-terminal domain kinase I (CTDK-I); which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; relocalizes to the cytosol in response to hypoxia" /codon_start=1 /product="Ctk2p" /protein_id="DAA08785.1" /db_xref="SGD:S000003543" /translation="MPSTFESQLFFSRPFLSKRQIQRAQKNTISDYRNYNQKKLAVFK FLSDLCVQLKFPRKTLETAVYFYQRYHLFNRFETEVCYTVATSCLTLGCKEVETIKKT NDICTLSLRLRNVVKINTDILENFKKRVFQIELRILESCSFDYRVNNYVHIDEYVIKI GRELSFDYKLCNLAWVIAYDALKLETILVIPQHSIALAILKIAYELLDNKNWSSKRYS LFETDEKSVNEAYFDIVNFYINSFDMCDLQRHLPADLLPIGVERFMELKKNAGPESGL PQIPDHLLNADPYITITRDNNVQERRYVLSLELINGESSINSSTRHA" gene complement(424432..424515) /gene="SUP51" /locus_tag="YNCJ0021C" tRNA complement(424432..424515) /gene="SUP51" /locus_tag="YNCJ0021C" /product="tRNA-Leu" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /experiment="EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]" /experiment="EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]" /note="Leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis; can mutate to suppress amber nonsense mutations" /db_xref="SGD:S000006650" gene 425157..431237 /gene="CYR1" /locus_tag="YJL005W" /gene_synonym="CDC35" /gene_synonym="FIL1" /gene_synonym="HSR1" /gene_synonym="SRA4" /gene_synonym="TSM0185" mRNA 425157..431237 /gene="CYR1" /locus_tag="YJL005W" /gene_synonym="CDC35" /gene_synonym="FIL1" /gene_synonym="HSR1" /gene_synonym="SRA4" /gene_synonym="TSM0185" /product="adenylate cyclase" CDS 425157..431237 /gene="CYR1" /locus_tag="YJL005W" /gene_synonym="CDC35" /gene_synonym="FIL1" /gene_synonym="HSR1" /gene_synonym="SRA4" /gene_synonym="TSM0185" /EC_number="4.6.1.1" /experiment="EXISTENCE:direct assay:GO:0004016 adenylate cyclase activity [PMID:2934138]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:22575457|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:22575457]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:2196438]" /experiment="EXISTENCE:genetic interaction:GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway [PMID:2934138]" /experiment="EXISTENCE:genetic interaction:GO:0007265 Ras protein signal transduction [PMID:2934138]" /experiment="EXISTENCE:mutant phenotype:GO:0004016 adenylate cyclase activity [PMID:6360999]" /note="Adenylate cyclase; required for cAMP production and cAMP-dependent protein kinase signaling; scaffold protein for Ras2-Ira interaction; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation" /codon_start=1 /product="adenylate cyclase" /protein_id="DAA08786.1" /db_xref="SGD:S000003542" /translation="MSSKPDTGSEISGPQRQEEQEQQIEQSSPTEANDRSIHDEVPKV KKRHEQNSGHKSRRNSAYSYYSPRSLSMTKSRESITPNGMDDVSISNVEHPRPTEPKI KRGPYLLKKTLSSLSMTSANSTHDDNKDHGYALNSSKTHNYTSTHNHHDGHHDHHHVQ FFPNRKPSLAETLFKRFSGSNSHDGNKSGKESKVANLSLSTVNPAPANRKPSKDSTLS NHLADNVPSTLRRKVSSLVRGSSVHDINNGIADKQIRPKAVAQSENTLHSSDVPNSKR SHRKSFLLGSTSSSSSRRGSNVSSMTNSDSASMATSGSHVLQHNVSNVSPTTKSKDSV NSESADHTNNKSEKVTPEYNENIPENSNSDNKREATTPTIETPISCKPSLFRLDTNLE DVTDITKTVPPTAVNSTLNSTHGTETASPKTVIMPEGPRKSVSMADLSVAAAAPNGEF TSTSNDRSQWVAPQSWDVETKRKKTKPKGRSKSRRSSIDADELDPMSPGPPSKKDSRH HHDRKDNESMVTAGDSNSSFVDICKENVPNDSKTALDTKSVNRLKSNLAMSPPSIRYA PSNLDGDYDTSSTSSSLPSSSISSEDTSSCSDSSSYTNAYMEANREQDNKTPILNKTK SYTKKFTSSSVNMNSPDGAQSSGLLLQDEKDDEVECQLEHYYKDFSDLDPKRHYAIRI FNTDDTFTTLSCTPATTVEEIIPALKRKFNITAQGNFQISLKVGKLSKILRPTSKPIL IERKLLLLNGYRKSDPLHIMGIEDLSFVFKFLFHPVTPSHFTPEQEQRIMRSEFVHVD LRNMDLTTPPIIFYQHTSEIESLDVSNNANIFLPLEFIESSIKLLSLRMVNIRASKFP SNITKAYKLVSLELQRNFIRKVPNSIMKLSNLTILNLQCNELESLPAGFVELKNLQLL DLSSNKFMHYPEVINYCTNLLQIDLSYNKIQSLPQSTKYLVKLAKMNLSHNKLNFIGD LSEMTDLRTLNLRYNRISSIKTNASNLQNLFLTDNRISNFEDTLPKLRALEIQENPIT SISFKDFYPKNMTSLTLNKAQLSSIPGELLTKLSFLEKLELNQNNLTRLPQEISKLTK LVFLSVARNKLEYIPPELSQLKSLRTLDLHSNNIRDFVDGMENLELTSLNISSNAFGN SSLENSFYHNMSYGSKLSKSLMFFIAADNQFDDAMWPLFNCFVNLKVLNLSYNNFSDV SHMKLESITELYLSGNKLTTLSGDTVLKWSSLKTLMLNSNQMLSLPAELSNLSQLSVF DVGANQLKYNISNYHYDWNWRNNKELKYLNFSGNRRFEIKSFISHDIDADLSDLTVLP QLKVLGLMDVTLNTTKVPDENVNFRLRTTASIINGMRYGVADTLGQRDYVSSRDVTFE RFRGNDDECLLCLHDSKNQNADYGHNISRIVRDIYDKILIRQLERYGDETDDNIKTAL RFSFLQLNKEINGMLNSVDNGADVANLSYADLLSGACSTVIYIRGKKLFAANLGDCMA ILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSRAVGFFDLLPHI HASPDISVVTLTKADEMLIVATHKLWEYMDVDTVCDIARENSTDPLRAAAELKDHAMA YGCTENITILCLALYENIQQQNRFTLNKNSLMTRRSTFEDTTLRRLQPEISPPTGNLA MVFTDIKSSTFLWELFPNAMRTAIKTHNDIMRRQLRIYGGYEVKTEGDAFMVAFPTPT SGLTWCLSVQLKLLDAQWPEEITSVQDGCQVTDRNGNIIYQGLSVRMGIHWGCPVPEL DLVTQRMDYLGPMVNKAARVQGVADGGQIAMSSDFYSEFNKIMKYHERVVKGKESLKE VYGEEIIGEVLEREIAMLESIGWAFFDFGEHKLKGLETKELVTIAYPKILASRHEFAS EDEQSKLINETMLFRLRVISNRLESIMSALSGGFIELDSRTEGSYIKFNPKVENGIMQ SISEKDALLFFDHVITRIESSVALLHLRQQRCSGLEICRNDKTSARSNIFNVVDELLQ MVKNAKDLST" gene complement(431589..432200) /gene="SYS1" /locus_tag="YJL004C" mRNA complement(431589..432200) /gene="SYS1" /locus_tag="YJL004C" /product="Sys1p" CDS complement(431589..432200) /gene="SYS1" /locus_tag="YJL004C" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:11726510]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:15077113]" /experiment="EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:8923208]" /experiment="EXISTENCE:mutant phenotype:GO:0034067 protein localization to Golgi apparatus [PMID:15077113|PMID:15077114]" /experiment="EXISTENCE:mutant phenotype:GO:0043001 Golgi to plasma membrane protein transport [PMID:16926193]" /note="Integral membrane protein of the Golgi; required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation" /codon_start=1 /product="Sys1p" /protein_id="DAA08787.1" /db_xref="SGD:S000003541" /translation="MVSIRRYLRVPNELKPSQIFKQDSLSPSKIGLQIVLLQIFYYTT AIVLFYCWAKLAGYDLNIKEWLFSWENIDFTNAYGLSISLLWLLDSLICVFFLTVIVG RSKLAWDFAITIHAINFIVVFLYTRKFPSFSWFFLQILSSLILIFLGTWTTRWRELRD TFFEGLVDPNEGEVGLVTPSQQHSNHSELEQSPIQLKDLESQI" gene 432644..433000 /gene="COX16" /locus_tag="YJL003W" mRNA 432644..433000 /gene="COX16" /locus_tag="YJL003W" /product="Cox16p" CDS 432644..433000 /gene="COX16" /locus_tag="YJL003W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:12446688]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:12446688]" /note="Mitochondrial inner membrane protein; required for assembly of cytochrome c oxidase" /codon_start=1 /product="Cox16p" /protein_id="DAA08788.1" /db_xref="SGD:S000003540" /translation="MSFSGKKFRSRRQQLVYEASLAGRYKKALSKHPFLFFGLPFCAT IVLGSFWLSSFTAIKYEQGDRKVQEINEEDILKIRKNQREFDIKEEYYRLQGLSEEDW EPVRVARLKDESENVW" gene complement(433221..434651) /gene="OST1" /locus_tag="YJL002C" /gene_synonym="NLT1" mRNA complement(433221..434651) /gene="OST1" /locus_tag="YJL002C" /gene_synonym="NLT1" /product="dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1" CDS complement(433221..434651) /gene="OST1" /locus_tag="YJL002C" /gene_synonym="NLT1" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:29301962]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006487 protein N-linked glycosylation [PMID:9015380]" /experiment="EXISTENCE:direct assay:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:29301962]" /experiment="EXISTENCE:direct assay:GO:0008250 oligosaccharyltransferase complex [PMID:10358084]" /experiment="EXISTENCE:direct assay:GO:0018279 protein N-linked glycosylation via asparagine [PMID:9988747]" /experiment="EXISTENCE:physical interaction:GO:0008250 oligosaccharyltransferase complex [PMID:9405463]" /note="Alpha subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins" /codon_start=1 /product="dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1" /protein_id="DAA08789.1" /db_xref="SGD:S000003539" /translation="MRQVWFSWIVGLFLCFFNVSSAAQYEPPATWENVDYKRTIDVSN AYISETIEITIKNIASEPATEYFTAFESGIFSKVSFFSAYFTNEATFLNSQLLANSTT APGDDGESEIRYGIIQFPNAISPQEEVSLVIKSFYNTVGIPYPEHVGMSEEQHLLWET NRLPLSAYDTKKASFTLIGSSSFEEYHPPNDESLLGKANGNSFEFGPWEDIPRFSSNE TLAIVYSHNAPLNQVVNLRRDIWLSHWASTIQFEEYYELTNKAAKLSKGFSRLELMKQ IQTQNMRQTHFVTVLDMLLPEGATDHYFTDLVGLVSTSHAERDHFFIRPRFPIFGGWN YNFTVGWTNKLSDFLHVSSGSDEKFVASIPILNGPPDTVYDNVELSVFLPEGAEIFDI DSPVPFTNVSIETQKSYFDLNKGHVKLTFSYRNLISQVANGQVLIKYDYPKSSFFKKP LSIACYIFTALMGVFVLKTLNMNVTN" gene 435163..435926 /gene="PRE3" /locus_tag="YJL001W" /gene_synonym="CRL21" mRNA join(435163..435227,435344..435926) /gene="PRE3" /locus_tag="YJL001W" /gene_synonym="CRL21" /product="proteasome core particle subunit beta 1" CDS join(435163..435227,435344..435926) /gene="PRE3" /locus_tag="YJL001W" /gene_synonym="CRL21" /EC_number="3.4.25.1" /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]" /experiment="EXISTENCE:direct assay:GO:0019774 proteasome core complex, beta-subunit complex [PMID:9087403]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:11545745|PMID:19029916]" /experiment="EXISTENCE:mutant phenotype:GO:0004175 endopeptidase activity [PMID:9207060|PMID:9312134]" /note="Beta 1 subunit of the 20S proteasome; responsible for cleavage after acidic residues in peptides" /codon_start=1 /product="proteasome core particle subunit beta 1" /protein_id="DAA08790.1" /db_xref="SGD:S000003538" /translation="MNGIQVDINRLKKGEVSLGTSIMAVTFKDGVILGADSRTTTGAY IANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFK ELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKN FRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL" centromere complement(436307..436425) /note="CEN10; Chromosome X centromere" /db_xref="SGD:S000006471" centromere complement(436307..436331) /note="CEN10_CDEIII of CEN10" centromere complement(436332..436415) /note="CEN10_CDEII of CEN10" centromere complement(436416..436425) /note="CEN10_CDEI of CEN10" gene 436802..438610 /gene="AVT1" /locus_tag="YJR001W" mRNA 436802..438610 /gene="AVT1" /locus_tag="YJR001W" /product="Avt1p" CDS 436802..438610 /gene="AVT1" /locus_tag="YJR001W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:27246536|PMID:11274162]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0003333 amino acid transmembrane transport [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0005302 L-tyrosine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0006865 amino acid transport [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0015186 L-glutamine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0015188 L-isoleucine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0015824 proline transport [PMID:27246536]" /note="Vacuolar transporter; imports large neutral amino acids into vacuole; targeted to vacuole via AP-3 pathway; member of family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters" /codon_start=1 /product="Avt1p" /protein_id="DAA08791.1" /db_xref="SGD:S000003761" /translation="MPEQEPLSPNGRKRSEVHYISIPLNRGSAFSPDDSVSQFQSDGF MTRRQSILDHPVGSFKGVNSLSRFATSLRRANSFRNIELNADNERSFFKESNDETYDP DTLAPALDGRRLSVTLNNAGRPRITNLANNDRVSTASMAIHDDDYGSIQNSTIGDSGS ILRPTASLTEMMSGGAGRRFTNNDMDSIVVKRVEGVDGKVVTLLAGQSTAPQTIFNSI NVLIGIGLLALPLGLKYAGWVIGLTMLAIFALATFCTAELLSRCLDTDPTLISYADLG YAAFGTKGRALISALFTLDLLGSGVSLVILFGDSLNALFPQYSTTFFKIVSFFIVTPP VFIPLSVLSNISLLGILSTTGTVLVICCCGLYKSSSPGSLVNPMETSMWPIDLKHLCL SIGLLSACWGGHAVFPNLKTDMRHPDKFKDCLKTTYKITSVTDIGTAVIGFLMFGNLV KDEITKNVLLTEGYPKFVYGLISALMTIIPIAKTPLNARPIVSVLDVLMNVQHIDEAA SAIKRRAAKGLQVFNRIFINVVFVLIAINFPEFDKIIAFLGAGLCFTICLILPCWFYL RLCKTTIKPWERVACHVTICISVVLSTLGVGAAIIS" gene 438865..440646 /gene="MPP10" /locus_tag="YJR002W" mRNA 438865..440646 /gene="MPP10" /locus_tag="YJR002W" /product="rRNA-processing protein MPP10" CDS 438865..440646 /gene="MPP10" /locus_tag="YJR002W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0034457 Mpp10 complex [PMID:17515605]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9315638]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9315638]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9315638]" /experiment="EXISTENCE:mutant phenotype:GO:0032040 small-subunit processome [PMID:12242301]" /note="Component of the SSU processome and 90S preribosome; required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p" /codon_start=1 /product="rRNA-processing protein MPP10" /protein_id="DAA08792.1" /db_xref="SGD:S000003762" /translation="MSELFGVLKSNAGRIILKDPSATSKDVKAYIDSVINTCKNGSIT KKAELDEITVDGLDANQVWWQVKLVLDSIDGDLIQGIQELKDVVTPSHNLSDGSTLNS SSGEESELEEAESVFKEKQMLSADVSEIEEQSNDSLSENDEEPSMDDEKTSAEAAREE FAEEKRISSGQDERHSSPDPYGINDKFFDLEKFNRDTLAAEDSNEASEGSEDEDIDYF QDMPSDDEEEEAIYYEDFFDKPTKEPVKKHSDVKDPKEDEELDEEEHDSAMDKVKLDL FADEEDEPNAEGVGEASDKNLSSFEKQQIEIRKQIEQLENEAVAEKKWSLKGEVKAKD RPEDALLTEELEFDRTAKPVPVITSEVTESLEDMIRRRIQDSNFDDLQRRTLLDITRK SQRPQFELSDVKSSKSLAEIYEDDYTRAEDESALSEELQKAHSEISELYANLVYKLDV LSSVHFVPKPASTSLEIRVETPTISMEDAQPLYMSNASSLAPQEIYNVGKAEKDGEIR LKNGVAMSKEELTREDKNRLRRALKRKRSKANLPNVNKRSKRNDVVDTLSKAKNITVI NQKGEKKDVSGKTKKSRSGPDSTNIKL" gene complement(440994..442553) /gene="MRX12" /locus_tag="YJR003C" mRNA complement(440994..442553) /gene="MRX12" /locus_tag="YJR003C" /product="Mrx12p" CDS complement(440994..442553) /gene="MRX12" /locus_tag="YJR003C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:16823961]" /note="Protein that associates with mitochondrial ribosome; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis" /codon_start=1 /product="Mrx12p" /protein_id="DAA08793.1" /db_xref="SGD:S000003763" /translation="MLRSLHSAATLSNKRFYSLISHSNRKNIIKKLLRHPSFDPIRHH LPEDITTIDPYSLSQNVIESLNKLEVPKKDAAMVHNMMIENLSDLDYGVATIHSNNLR DLDLKPSLPAIKQIIRNNPGRVQSSWELFTQYKASMENVPDELMEVVLEKIIKFDKAE KVDGKKSLTYQDLVRCLYLINHFSSNYNLPSELVEPILIYIVDNGIPNVLGSVLKYKI PLSFFDKYVSEMTQYQICELYDFYSLDNIVADPLVLHKCLTVLGENEKIQQTEEEKEI ISKLEEEIDIVKSQCHDNWSLEFPNWSVRKTATSFEELFLEIQKRNIDKKDFELAHKL LRLIGAFKGKVSLFFKLYDEYLLKFKNNEDDLMFEAFLTLCCQGYKSSNEKMLQYAEA FIKEDFDSKLESKIQSVLIVANAKANIDLSLKIYNSNISTAKREKDKYTDLAESDVLT ESLILAFLSRDDADFARVIFDGALGEKLISGPTAAKKIKNLLAQYGEALETKTSKQVM QTKIEHYMESI" rep_origin 442556..442965 /note="ARS1015; Autonomously Replicating Sequence" /db_xref="SGD:S000028452" gene complement(442909..444861) /gene="SAG1" /locus_tag="YJR004C" /gene_synonym="AG(ALPHA)1" mRNA complement(442909..444861) /gene="SAG1" /locus_tag="YJR004C" /gene_synonym="AG(ALPHA)1" /product="Sag1p" CDS complement(442909..444861) /gene="SAG1" /locus_tag="YJR004C" /gene_synonym="AG(ALPHA)1" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000752 agglutination involved in conjugation with cellular fusion [PMID:2677666|PMID:2673555]" /experiment="EXISTENCE:mutant phenotype:GO:0050839 cell adhesion molecule binding [PMID:2673555|PMID:2677666|PMID:11369849]" /note="Alpha-agglutinin of alpha-cells; binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor" /codon_start=1 /product="Sag1p" /protein_id="DAA08794.1" /db_xref="SGD:S000003764" /translation="MFTFLKIILWLFSLALASAININDITFSNLEITPLTANKQPDQG WTATFDFSIADASSIREGDEFTLSMPHVYRIKLLNSSQTATISLADGTEAFKCYVSQQ AAYLYENTTFTCTAQNDLSSYNTIDGSITFSLNFSDGGSSYEYELENAKFFKSGPMLV KLGNQMSDVVNFDPAAFTENVFHSGRSTGYGSFESYHLGMYCPNGYFLGGTEKIDYDS SNNNVDLDCSSVQVYSSNDFNDWWFPQSYNDTNADVTCFGSNLWITLDEKLYDGEMLW VNALQSLPANVNTIDHALEFQYTCLDTIANTTYATQFSTTREFIVYQGRNLGTASAKS SFISTTTTDLTSINTSAYSTGSISTVETGNRTTSEVISHVVTTSTKLSPTATTSLTIA QTSIYSTDSNITVGTDIHTTSEVISDVETISRETASTVVAAPTSTTGWTGAMNTYISQ FTSSSFATINSTPIISSSAVFETSDASIVNVHTENITNTAAVPSEEPTFVNATRNSLN SFCSSKQPSSPSSYTSSPLVSSLSVSKTLLSTSFTPSVPTSNTYIKTKNTGYFEHTAL TTSSVGLNSFSETAVSSQGTKIDTFLVSSLIAYPSSASGSQLSGIQQNFTSTSLMIST YEGKASIFFSAELGSIIFLLLSYLLF" gene 445923..448025 /gene="APL1" /locus_tag="YJR005W" /gene_synonym="YAP80" mRNA 445923..448025 /gene="APL1" /locus_tag="YJR005W" /gene_synonym="YAP80" /product="Apl1p" CDS 445923..448025 /gene="APL1" /locus_tag="YJR005W" /gene_synonym="YAP80" /experiment="EXISTENCE:curator inference:GO:0016192 vesicle-mediated transport [PMID:22190733]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030122 AP-2 adaptor complex [PMID:10564262]" /experiment="EXISTENCE:direct assay:GO:0030139 endocytic vesicle [PMID:22190733]" /note="Beta-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex" /codon_start=1 /product="Apl1p" /protein_id="DAA08795.1" /db_xref="SGD:S000003765" /translation="MSDQKVFARYKANEIVTDLQHFGVKKFKSNITRRKNALRKIIAN LVLGNYGEMSVLFSELLKFWQIEDDLEVKRICHEYIRVIGALKPQQAREALPFIMDDF KSRDEKLQIMALRTLVLVPVKELSDQAFDCIISLVNHKSPPEQVTRTAIYALLDLDEI DHERVLGLSSILHDIVKAQSSSPEVIVAALHTLYSIHEKNANMEPFRIPLELAFDMLE LLPELNEWNKATVLEVLTTSVVPQHYLDTHEMIELALPYLQQVNTYVVLNSLKFIMYL LNYVDVIKETLAEKLSNSVIALLDKPPELQFLVLRNVILLLLSRESSLLRLDISYFFI EYNDPIYIKDTKLECLYLLANKETLPRILEELEQYATDIDIQMSRKSVRAIGNLAVKL DEDSVHDCVAVLLDLLEFGVDYVVQEIISVFRNILRKYPNNFKANVTELVKHTEVVQE PESKNAMIWIITQYSDVIPNYLELFRVFSSNMFSETLEVQFSILNSAIKFFIRSPTKE TEELCMDLLKGCIDHENNPDLRDKTLMYWRLLSLTKTSRISNAITFESLKSVLDGELP LIEMNTKLDPTVLEELELNIGTIVSIYLKPVSHIFRLNKTKLLPQSPILNPNKDLLPV VGNSFPPTGANRDRQNSESQSSTKSRKTAMMDDYDKPAEKINQLKGKRKSSSNNPSKL SRKPSTLLRKLSMKRPFS" gene complement(448477..448758) /gene="LSO1" /locus_tag="YJR005C-A" mRNA complement(448477..448758) /gene="LSO1" /locus_tag="YJR005C-A" /product="Lso1p" CDS complement(448477..448758) /gene="LSO1" /locus_tag="YJR005C-A" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26450372]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:26450372]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:26450372]" /note="Protein with a potential role in response to iron deprivation; transcription increases during iron deprivation and during treatment with 2-(6-benzyl-2-pyridyl)quinazoline (BPQ) and copper; regulated by Aft1p and, to a lesser extent, by Aft2p; originally identified as a syntenic homolog of an Ashbya gossypii gene; localizes to nucleus and cytoplasm, and nuclear localization is enhanced under iron-replete conditions" /codon_start=1 /product="Lso1p" /protein_id="DAA08796.1" /db_xref="SGD:S000028523" /translation="MHNTGKRYSETAKKVAAGRARKRRQAYEKDQLEKQQLEAQEAQR WEEGARTPNQKKLIMEQKKTEKLRAKKERDQLLAAEEEALGKGGRGKRY" gene 449202..450665 /gene="POL31" /locus_tag="YJR006W" /gene_synonym="HUS2" /gene_synonym="HYS2" /gene_synonym="SDP5" mRNA 449202..450665 /gene="POL31" /locus_tag="YJR006W" /gene_synonym="HUS2" /gene_synonym="HYS2" /gene_synonym="SDP5" /product="DNA-directed DNA polymerase delta subunit POL31" CDS 449202..450665 /gene="POL31" /locus_tag="YJR006W" /gene_synonym="HUS2" /gene_synonym="HYS2" /gene_synonym="SDP5" /EC_number="2.7.7.7" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:18635534]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006278 RNA-templated DNA biosynthetic process [PMID:17429354]" /experiment="EXISTENCE:direct assay:GO:0016035 zeta DNA polymerase complex [PMID:22711820|PMID:23066099]" /experiment="EXISTENCE:direct assay:GO:0043137 DNA replication, removal of RNA primer [PMID:16837458]" /note="Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair; forms a complex with Rev3p, Rev7p and Pol32p; relocalizes to the cytosol in response to hypoxia" /codon_start=1 /product="DNA-directed DNA polymerase delta subunit POL31" /protein_id="DAA08797.1" /db_xref="SGD:S000003766" /translation="MDALLTKFNEDRSLQDENLSQPRTRVRIVDDNLYNKSNPFQLCY KKRDYGSQYYHIYQYRLKTFRERVLKECDKRWDAGFTLNGQLVLKKDKVLDIQGNQPC WCVGSIYCEMKYKPNVLDEVINDTYGAPDLTKSYTDKEGGSDEIMLEDESGRVLLVGD FIRSTPFITGVVVGILGMEAEAGTFQVLDICYPTPLPQNPFPAPIATCPTRGKIALVS GLNLNNTSPDRLLRLEILREFLMGRINNKIDDISLIGRLLICGNSVDFDIKSVNKDEL MISLTEFSKFLHNILPSISVDIMPGTNDPSDKSLPQQPFHKSLFDKSLESYFNGSNKE ILNLVTNPYEFSYNGVDVLAVSGKNINDICKYVIPSNDNGESENKVEEGESNDFKDDI EHRLDLMECTMKWQNIAPTAPDTLWCYPYTDKDPFVLDKWPHVYIVANQPYFGTRVVE IGGKNIKIISVPEFSSTGMIILLDLETLEAETVKIDI" gene 451020..451934 /gene="SUI2" /locus_tag="YJR007W" mRNA 451020..451934 /gene="SUI2" /locus_tag="YJR007W" /product="translation initiation factor eIF2 subunit alpha" CDS 451020..451934 /gene="SUI2" /locus_tag="YJR007W" /experiment="EXISTENCE:direct assay:GO:0001731 formation of translation preinitiation complex [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:16246727|PMID:14698289]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:8947054]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0033290 eukaryotic 48S preinitiation complex [PMID:17242201]" /experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF complex [PMID:11018020|PMID:15838098]" /experiment="EXISTENCE:direct assay:GO:1990856 methionyl-initiator methionine tRNA binding [PMID:16565414]" /experiment="EXISTENCE:mutant phenotype:GO:0005850 eukaryotic translation initiation factor 2 complex [PMID:2649894]" /note="Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="translation initiation factor eIF2 subunit alpha" /protein_id="DAA08798.1" /db_xref="SGD:S000003767" /translation="MSTSHCRFYENKYPEIDDIVMVNVQQIAEMGAYVKLLEYDNIEG MILLSELSRRRIRSIQKLIRVGKNDVAVVLRVDKEKGYIDLSKRRVSSEDIIKCEEKY QKSKTVHSILRYCAEKFQIPLEELYKTIAWPLSRKFGHAYEAFKLSIIDETVWEGIEP PSKDVLDELKNYISKRLTPQAVKIRADVEVSCFSYEGIDAIKDALKSAEDMSTEQMQV KVKLVAAPLYVLTTQALDKQKGIEQLESAIEKITEVITKYGGVCNITMPPKAVTATED AELQALLESKELDNRSDSEDDEDESDDE" gene 452430..453446 /gene="MHO1" /locus_tag="YJR008W" mRNA 452430..453446 /gene="MHO1" /locus_tag="YJR008W" /product="Mho1p" CDS 452430..453446 /gene="MHO1" /locus_tag="YJR008W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22412880]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22412880|PMID:14562095]" /note="hypothetical protein; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility" /codon_start=1 /product="Mho1p" /protein_id="DAA08799.1" /db_xref="SGD:S000003768" /translation="MSIRPATHAGSWYSNRAQELSQQLHTYLIKSTLKGPIHNARIII CPHAGYRYCGPTMAYSYASLDLNRNVKRIFILGPSHHIYFKNQILVSAFSELETPLGN LKVDTDLCKTLIQKEYPENGKKLFKPMDHDTDMAEHSLEMQLPMLVETLKWREISLDT VKVFPMMVSHNSVDVDRCIGNILSEYIKDPNNLFIVSSDFCHWGRRFQYTGYVGSKEE LNDAIQEETEVEMLTARSKLSHHQVPIWQSIEIMDRYAMKTLSDTPNGERYDAWKQYL EITGNTICGEKPISVILSALSKIRDAGPSGIKFQWPNYSQSSHVTSIDDSSVSYASGY VTIG" gene complement(453683..454681) /gene="TDH2" /locus_tag="YJR009C" /gene_synonym="GLD2" mRNA complement(453683..454681) /gene="TDH2" /locus_tag="YJR009C" /gene_synonym="GLD2" /product="glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2" CDS complement(453683..454681) /gene="TDH2" /locus_tag="YJR009C" /gene_synonym="GLD2" /EC_number="1.2.1.12" /experiment="EXISTENCE:direct assay:GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [PMID:3905788]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16962558]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:10515935]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11158358|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11158358]" /experiment="EXISTENCE:direct assay:GO:1904408 melatonin binding [PMID:31708896]" /experiment="EXISTENCE:direct assay:GO:1990841 promoter-specific chromatin binding [PMID:27184763]" /experiment="EXISTENCE:expression pattern:GO:0006094 gluconeogenesis [PMID:3905788]" /experiment="EXISTENCE:expression pattern:GO:0006096 glycolytic process [PMID:3905788]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:17726063]" /experiment="EXISTENCE:mutant phenotype:GO:0072593 reactive oxygen species metabolic process [PMID:17726063]" /note="Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides are active against a wide variety of wine-related yeasts and bateria; TDH2 has a paralog, TDH3, that arose from the whole genome duplication" /codon_start=1 /product="glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2" /protein_id="DAA08800.1" /db_xref="SGD:S000003769" /translation="MVRVAINGFGRIGRLVMRIALQRKNVEVVALNDPFISNDYSAYM FKYDSTHGRYAGEVSHDDKHIIVDGHKIATFQERDPANLPWASLNIDIAIDSTGVFKE LDTAQKHIDAGAKKVVITAPSSTAPMFVMGVNEEKYTSDLKIVSNASCTTNCLAPLAK VINDAFGIEEGLMTTVHSMTATQKTVDGPSHKDWRGGRTASGNIIPSSTGAAKAVGKV LPELQGKLTGMAFRVPTVDVSVVDLTVKLNKETTYDEIKKVVKAAAEGKLKGVLGYTE DAVVSSDFLGDSNSSIFDAAAGIQLSPKFVKLVSWYDNEYGYSTRVVDLVEHVAKA" rep_origin 454584..455555 /note="ARS1016; Autonomously Replicating Sequence" /db_xref="SGD:S000028453" gene 456239..457774 /gene="MET3" /locus_tag="YJR010W" mRNA 456239..457774 /gene="MET3" /locus_tag="YJR010W" /product="sulfate adenylyltransferase" CDS 456239..457774 /gene="MET3" /locus_tag="YJR010W" /EC_number="2.7.7.4" /experiment="EXISTENCE:direct assay:GO:0004781 sulfate adenylyltransferase (ATP) activity [PMID:10092498]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0000096 sulfur amino acid metabolic process [PMID:1101032]" /experiment="EXISTENCE:mutant phenotype:GO:0004781 sulfate adenylyltransferase (ATP) activity [PMID:197388]" /experiment="EXISTENCE:mutant phenotype:GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [PMID:197388]" /note="ATP sulfurylase; catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant" /codon_start=1 /product="sulfate adenylyltransferase" /protein_id="DAA08801.1" /db_xref="SGD:S000003771" /translation="MPAPHGGILQDLIARDALKKNELLSEAQSSDILVWNLTPRQLCD IELILNGGFSPLTGFLNENDYSSVVTDSRLADGTLWTIPITLDVDEAFANQIKPDTRI ALFQDDEIPIAILTVQDVYKPNKTIEAEKVFRGDPEHPAISYLFNVAGDYYVGGSLEA IQLPQHYDYPGLRKTPAQLRLEFQSRQWDRVVAFQTRNPMHRAHRELTVRAAREANAK VLIHPVVGLTKPGDIDHHTRVRVYQEIIKRYPNGIAFLSLLPLAMRMSGDREAVWHAI IRKNYGASHFIVGRDHAGPGKNSKGVDFYGPYDAQELVESYKHELDIEVVPFRMVTYL PDEDRYAPIDQIDTTKTRTLNISGTELRRRLRVGGEIPEWFSYPEVVKILRESNPPRP KQGFSIVLGNSLTVSREQLSIALLSTFLQFGGGRYYKIFEHNNKTELLSLIQDFIGSG SGLIIPNQWEDDKDSVVGKQNVYLLDTSSSADIQLESADEPISHIVQKVVLFLEDNGF FVF" gene complement(458077..458361) /gene="SPC1" /locus_tag="YJR010C-A" mRNA complement(458077..458361) /gene="SPC1" /locus_tag="YJR010C-A" /product="signal peptidase complex subunit SPC1" CDS complement(458077..458361) /gene="SPC1" /locus_tag="YJR010C-A" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005787 signal peptidase complex [PMID:1846444|PMID:8910564]" /experiment="EXISTENCE:genetic interaction:GO:0006465 signal peptide processing [PMID:8663399]" /experiment="EXISTENCE:genetic interaction:GO:0045047 protein targeting to ER [PMID:8663399]" /experiment="EXISTENCE:mutant phenotype:GO:0006465 signal peptide processing [PMID:8663399]" /experiment="EXISTENCE:physical interaction:GO:0045047 protein targeting to ER [PMID:8663399]" /note="Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); regulates cellular levels of membrane proteins; homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="signal peptidase complex subunit SPC1" /protein_id="DAA08802.1" /db_xref="SGD:S000003770" /translation="MSEILQDVQRKLVFPIDFPSQRKTEKFQQLSLMIGALVACILGF AQQSLKVLLTAYGISCVITLICVLPAYPWYNKQKLRWAQPKIEINVDQYD" gene complement(458641..459426) /gene="CAL4" /locus_tag="YJR011C" mRNA complement(458641..459426) /gene="CAL4" /locus_tag="YJR011C" /product="Cal4p" CDS complement(458641..459426) /gene="CAL4" /locus_tag="YJR011C" /note="Accessory component of the Ccr4-NOT complex; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS" /codon_start=1 /product="Cal4p" /protein_id="DAA08803.1" /db_xref="SGD:S000003772" /translation="MSETRESNESTVSSLQTKLLLNDGISENNKKNVILLNQIVPFIL NTSHYMTDLMYVLYYLAQKQEDEVLNHSGTFISHKKELLALKSDICELIYDLRTGFRL LLDSCELDHFETPGKCRHLIEKVLVTSIYGVNRYIFQELNRLNVDFKDEFILQMQNCL SGFVNLYKFLNKIPMSKQQSQMNDLQMKILVNVLQNELLPIWKFQLDLLNCKLFNELS KDKGLINIYRKATNDSVIDVSKGEPFIRYVNWLKDQIIGEMTV" rep_origin 459337..459895 /note="ARS1017; Autonomously Replicating Sequence" /db_xref="SGD:S000028454" gene complement(459795..460193) /locus_tag="YJR012C" mRNA complement(459795..460193) /locus_tag="YJR012C" /product="hypothetical protein" CDS complement(459795..460193) /locus_tag="YJR012C" /note="hypothetical protein; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; null mutant is viable" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08804.2" /db_xref="SGD:S000003773" /translation="MAAGGELSYEELLDHILNNKPIPNIVEVPNVTLDEGLASTPSLR PRPRPWEGQLQHQSHQGSLDKPNISLDIDQESLEGMTSLTRLSECYDIQSKLQINDSD NDNDDNNNDNNKGDGNDDDNNTVTANPTAR" gene 460382..461593 /gene="GPI14" /locus_tag="YJR013W" /gene_synonym="PMH1" mRNA 460382..461593 /gene="GPI14" /locus_tag="YJR013W" /gene_synonym="PMH1" /product="glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I" CDS 460382..461593 /gene="GPI14" /locus_tag="YJR013W" /gene_synonym="PMH1" /experiment="EXISTENCE:direct assay:GO:0000030 mannosyltransferase activity [PMID:15635094]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:16134120]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:16134120]" /experiment="EXISTENCE:physical interaction:GO:0006506 GPI anchor biosynthetic process [PMID:15635094]" /experiment="EXISTENCE:physical interaction:GO:1990529 glycosylphosphatidylinositol-mannosyltransferase I complex [PMID:15635094]" /note="Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I; involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M" /codon_start=1 /product="glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I" /protein_id="DAA08805.1" /db_xref="SGD:S000003774" /translation="MTGEEWGLTVLSFLVRVGFFLFGIYQDANFKVRYTDIDYFVFHD AAKYVYEGKSPYARDTYRYTPLLSWLLVPNHYFGWFHLGKVIFVIFDLVTGLIIMKLL NQAISRKRALILESIWLLNPMVITISTRGNAESVLCCLIMFTLFFLQKSRYTLAGILY GLSIHFKIYPIIYCIPIAIFIYYNKRNQGPRTQLTSLLNIGLSTLTTLLGCGWAMYKI YGYEFLDQAYLYHLYRTDHRHNFSVWNMLLYLDSANKENGESNLSRYAFVPQLLLVLV TGCLEWWNPTFDNLLRVLFVQTFAFVTYNKVCTSQYFVWYLIFLPFYLSRTHIGWKKG LLMATLWVGTQGIWLSQGYYLEFEGKNVFYPGLFIASVLFFVTNVWLLGQFITDIKIP TQPTVSNKKNN" gene 461829..462425 /gene="TMA22" /locus_tag="YJR014W" mRNA 461829..462425 /gene="TMA22" /locus_tag="YJR014W" /product="Tma22p" CDS 461829..462425 /gene="TMA22" /locus_tag="YJR014W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:38198768]" /experiment="EXISTENCE:mutant phenotype:GO:0032790 ribosome disassembly [PMID:34016977]" /note="Ribosome-associated protein; involved along with heterodimeric partner Tma20p in recycling of 40S ribosomal subunits; involved in nonsense-mediated mRNA decay (NMD); contains a putative RNA binding domain; localizes to the cytoplasm in HTP studies; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="Tma22p" /protein_id="DAA08806.1" /db_xref="SGD:S000003775" /translation="MLREVIYCGICSYPPEYCEFSGKLKRCKVWLSENHADLYAKLYG TDDNTQEVEAVTNKLAESSIGEAREEKLEKDLLKIQKKQENREQRELAKKLSSKVIIK REARTKRKFIVAISGLEVFDIDMKKLAKTFASRFATGCSVSKNAEKKEEVVIQGDVMD EVETYIHSLLEEKGLKDVKVETIDAKKKKKPAAEGAAK" gene 462721..464253 /locus_tag="YJR015W" mRNA 462721..464253 /locus_tag="YJR015W" /product="hypothetical protein" CDS 462721..464253 /locus_tag="YJR015W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /note="hypothetical protein; localizes to endoplasmic reticulum and cytoplasm; null mutant exhibits abnormal lipid metabolic phenotype; predicted to encode a membrane transporter based on phylogenetic analysis; not an essential gene; YJR015W has a paralog, SNG1, that arose from the whole genome duplication" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08807.1" /db_xref="SGD:S000003776" /translation="MTSSLDDIEPTAYNNMEADEEYCRRNDIHDLSSVVGDAVSQGVP DMDGQTTDSSKDPEPNSEDKKAFPPSSGSFFSPNLQGQRKKVLLKFVFTNCLLAIICF TMFVLFWGALYDTSKYLHKVKLLVVIQEPPVVILDNNSSMVVPSISYALPTFINKIPC DWDIYNSPTFQAKFDVNTPQQVNDKVVDLVYDEKYWFAINIKPNATETLFESLINDTA PLFNSTLFNQVVYETGRDPTNLKSTILPVAQTIEEYYHTFYTLNYLPPLLTNITQVYR YALTNNARYIAAAGKYNYEYYDHRPFTDRILLAPTQIGVVYCLLLTFFQFLLYGPLHV EMAKVLRPANGLIYRIAMSWFTFFFASLFFCTTTAIFQVDFTKSFGRGGFVVYWMSTW LFMLAAGGANENAVMLVITLGPQYLGFWILSFVILNIAPSFFPLALNNNVYRYGYMMP VHNVIDIYRVIFFDVTRRKMGRNYGILVALIALNTALLPFVGKYASRKLKQKALVAAK QS" gene complement(464451..466208) /gene="ILV3" /locus_tag="YJR016C" mRNA complement(464451..466208) /gene="ILV3" /locus_tag="YJR016C" /product="dihydroxy-acid dehydratase ILV3" CDS complement(464451..466208) /gene="ILV3" /locus_tag="YJR016C" /EC_number="4.2.1.9" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0004160 dihydroxy-acid dehydratase activity [PMID:14124940]" /experiment="EXISTENCE:mutant phenotype:GO:0009082 branched-chain amino acid biosynthetic process [PMID:14124940]" /note="Dihydroxyacid dehydratase; putative 2Fe-2S protein; catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids" /codon_start=1 /product="dihydroxy-acid dehydratase ILV3" /protein_id="DAA08808.1" /db_xref="SGD:S000003777" /translation="MGLLTKVATSRQFSTTRCVAKKLNKYSYIITEPKGQGASQAMLY ATGFKKEDFKKPQVGVGSCWWSGNPCNMHLLDLNNRCSQSIEKAGLKAMQFNTIGVSD GISMGTKGMRYSLQSREIIADSFETIMMAQHYDANIAIPSCDKNMPGVMMAMGRHNRP SIMVYGGTILPGHPTCGSSKISKNIDIVSAFQSYGEYISKQFTEEEREDVVEHACPGP GSCGGMYTANTMASAAEVLGLTIPNSSSFPAVSKEKLAECDNIGEYIKKTMELGILPR DILTKEAFENAITYVVATGGSTNAVLHLVAVAHSAGVKLSPDDFQRISDTTPLIGDFK PSGKYVMADLINVGGTQSVIKYLYENNMLHGNTMTVTGDTLAERAKKAPSLPEGQEII KPLSHPIKANGHLQILYGSLAPGGAVGKITGKEGTYFKGRARVFEEEGAFIEALERGE IKKGEKTVVVIRYEGPRGAPGMPEMLKPSSALMGYGLGKDVALLTDGRFSGGSHGFLI GHIVPEAAEGGPIGLVRDGDEIIIDADNNKIDLLVSDKEMAQRKQSWVAPPPRYTRGT LSKYAKLVSNASNGCVLDA" gene complement(466521..467033) /gene="ESS1" /locus_tag="YJR017C" /gene_synonym="PIN1" /gene_synonym="PTF1" mRNA complement(466521..467033) /gene="ESS1" /locus_tag="YJR017C" /gene_synonym="PIN1" /gene_synonym="PTF1" /product="peptidylprolyl isomerase ESS1" CDS complement(466521..467033) /gene="ESS1" /locus_tag="YJR017C" /gene_synonym="PIN1" /gene_synonym="PTF1" /EC_number="5.2.1.8" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:10899126|PMID:14704159|PMID:10531363]" /experiment="EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:15728580|PMID:9867817]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:14704159]" /experiment="EXISTENCE:genetic interaction:GO:0006369 termination of RNA polymerase II transcription [PMID:19854134]" /experiment="EXISTENCE:genetic interaction:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:15166139]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10899126]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:14704159]" /experiment="EXISTENCE:mutant phenotype:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:15728580]" /experiment="EXISTENCE:mutant phenotype:GO:0006369 termination of RNA polymerase II transcription [PMID:22778132|PMID:14704159|PMID:19854134]" /experiment="EXISTENCE:mutant phenotype:GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process [PMID:19597489]" /experiment="EXISTENCE:mutant phenotype:GO:2000749 positive regulation of rDNA heterochromatin formation [PMID:10899127]" /experiment="EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:10531363|PMID:10899126]" /experiment="EXISTENCE:physical interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10899126]" /note="Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated S/T residues N-terminal to proline; regulates phosphorylation of RNAPII large subunit (Rpo21p) C-terminal domain (CTD) at Ser7; associates with phospho-Ser5 form of RNAPII in vivo; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription, trimethylation of histone H3; human ortholog PIN1 can complement yeast null and ts mutants" /codon_start=1 /product="peptidylprolyl isomerase ESS1" /protein_id="DAA08809.1" /db_xref="SGD:S000003778" /translation="MPSDVASRTGLPTPWTVRYSKSKKREYFFNPETKHSQWEEPEGT NKDQLHKHLRDHPVRVRCLHILIKHKDSRRPASHRSENITISKQDATDELKTLITRLD DDSKTNSFEALAKERSDCSSYKRGGDLGWFGRGEMQPSFEDAAFQLKVGEVSDIVESG SGVHVIKRVG" gene complement(467232..468281) /gene="TES1" /locus_tag="YJR019C" /gene_synonym="PTE1" mRNA complement(467232..468281) /gene="TES1" /locus_tag="YJR019C" /gene_synonym="PTE1" /product="palmitoyl-CoA hydrolase" CDS complement(467232..468281) /gene="TES1" /locus_tag="YJR019C" /gene_synonym="PTE1" /EC_number="3.1.2.2" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:10092594]" /experiment="EXISTENCE:direct assay:GO:0047617 fatty acyl-CoA hydrolase activity [PMID:10092594]" /experiment="EXISTENCE:mutant phenotype:GO:0006635 fatty acid beta-oxidation [PMID:19830908]" /experiment="EXISTENCE:mutant phenotype:GO:0019395 fatty acid oxidation [PMID:10092594]" /note="Peroxisomal acyl-CoA thioesterase; likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids" /codon_start=1 /product="palmitoyl-CoA hydrolase" /protein_id="DAA08810.1" /db_xref="SGD:S000003780" /translation="MSASKMAMSNLEKILELVPLSPTSFVTKYLPAAPVGSKGTFGGT LVSQSLLASLHTVPLNFFPTSLHSYFIKGGDPRTKITYHVQNLRNGRNFIHKQVSAYQ HDKLIFTSMILFAVQRSKEHDSLQHWETIPGLQGKQPDPHRYEEATSLFQKEVLDPQK LSRYASLSDRFQDATSMSKYVDAFQYGVMEYQFPKDMFYSARHTDELDYFVKVRPPIT TVEHAGDESSLHKHHPYRIPKSITPENDARYNYVAFAYLSDSYLLLTIPYFHNLPLYC HSFSVSLDHTIYFHQLPHVNNWIYLKISNPRSHWDKHLVQGKYFDTQSGRIMASVSQE GYVVYGSERDIRAKF" gene complement(468555..469579) /gene="REC107" /locus_tag="YJR021C" /gene_synonym="MER2" mRNA complement(join(468555..469183,469264..469579)) /gene="REC107" /locus_tag="YJR021C" /gene_synonym="MER2" /product="Rec107p" CDS complement(join(468555..469183,469264..469579)) /gene="REC107" /locus_tag="YJR021C" /gene_synonym="MER2" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:16783010]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:8536989]" /note="Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation" /codon_start=1 /product="Rec107p" /protein_id="DAA08811.1" /db_xref="SGD:S000003782" /translation="MVARGRTDEISTDVSEANSEHSLMITETSSPFRSIFSHSGKVAN AGALEESDKQILEWAGKLELESMELRENSDKLIKVLNENSKTLCKSLNKFNQLLEQDA ATNGNVKTLIKDLASQIENQLDKVSTAMLSKGDEKKTKSDSSYRQVLVEEISRYNSKI TRHVTNKQHETEKSMRCTQEMLFNVGSQLEDVHKVLLSLSKDMHSLQTRQTALEMAFR EKADHAYDRPDVSLNGTTLLHDMDEAHDKQRKKSVPPPRMMVTRSMKRRRSSSPTLST SQNHNSEDNDDASHRLKRAARTIIPWEELRPDTLESEL" gene 469784..470113 /gene="LSM8" /locus_tag="YJR022W" mRNA 469784..470113 /gene="LSM8" /locus_tag="YJR022W" /product="U4/U6-U5 snRNP complex subunit LSM8" CDS 469784..470113 /gene="LSM8" /locus_tag="YJR022W" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:10369684|PMID:15075370]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12730603]" /experiment="EXISTENCE:direct assay:GO:0005688 U6 snRNP [PMID:11720284|PMID:10369684]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:18029398]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:10428970]" /note="Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA" /codon_start=1 /product="U4/U6-U5 snRNP complex subunit LSM8" /protein_id="DAA08812.1" /db_xref="SGD:S000003783" /translation="MSATLKDYLNKRVVIIKVDGECLIASLNGFDKNTNLFITNVFNR ISKEFICKAQLLRGSEIALVGLIDAENDDSLAPIDEKKVPMLKDTKNKIENEHVIWEK VYESKTK" gene complement(470230..470964) /gene="MDE1" /locus_tag="YJR024C" mRNA complement(470230..470964) /gene="MDE1" /locus_tag="YJR024C" /product="methylthioribulose 1-phosphate dehydratase MDE1" CDS complement(470230..470964) /gene="MDE1" /locus_tag="YJR024C" /EC_number="4.2.1.109" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0019509 L-methionine salvage from methylthioadenosine [PMID:18625006]" /experiment="EXISTENCE:mutant phenotype:GO:0046570 methylthioribulose 1-phosphate dehydratase activity [PMID:18625006]" /note="5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant" /codon_start=1 /product="methylthioribulose 1-phosphate dehydratase MDE1" /protein_id="DAA08813.1" /db_xref="SGD:S000003785" /translation="MSSQDVLIHSDDPCHPANLICTLCKQFFHNNWCTGTGGGISIKD PNTNYYYLAPSGVQKEKMIPEDLFVMDAQTLEYLRSPKLYKPSACTPLFLACYQKKNA GAIIHTHSQNAVICSLLFGDEFRIANIEQIKAIPSGKVDPVTKKPMALSFFDTLKIPI IENMAHEDELIDDLHKTFKDYPDTCAVIVRRHGIFVWGPTIDKAKIFNEAIDYLMELA IKMYQMGIPPDCGIGEEKKHLKMASP" gene complement(471138..471671) /gene="BNA1" /locus_tag="YJR025C" /gene_synonym="HAD1" mRNA complement(471138..471671) /gene="BNA1" /locus_tag="YJR025C" /gene_synonym="HAD1" /product="3-hydroxyanthranilate 3,4-dioxygenase" CDS complement(471138..471671) /gene="BNA1" /locus_tag="YJR025C" /gene_synonym="HAD1" /EC_number="1.13.11.6" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11901108]" /experiment="EXISTENCE:genetic interaction:GO:0034354 'de novo' NAD biosynthetic process from tryptophan [PMID:12062417]" /experiment="EXISTENCE:mutant phenotype:GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activity [PMID:9539135]" /note="3-hydroxyanthranilic acid dioxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p" /codon_start=1 /product="3-hydroxyanthranilate 3,4-dioxygenase" /protein_id="DAA08814.1" /db_xref="SGD:S000003786" /translation="MFNTTPINIDKWLKENEGLLKPPVNNYCLHKGGFTVMIVGGPNE RTGYHINPTPEWFYQKKGSMLLKVVDETDAEPKFIDIIINEGDSYLLPGNVPHSPVRF ADTVGIVVEQDRPGGENDKIRWYCSHCRQVVHESELQMLDLGTQVKEAILDFENDVEK RTCFHCKTLNYARPQSN" mobile_element 472463..478384 /note="YJRWTy1-1; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats" /mobile_element_type="retrotransposon:YJRWTy1-1" /db_xref="SGD:S000007048" repeat_region 472463..472800 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007040" gene 472760..478028 /locus_tag="YJR027W" mRNA 472760..478028 /locus_tag="YJR027W" /product="gag-pol fusion protein" CDS join(472760..474061,474063..478028) /locus_tag="YJR027W" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /codon_start=1 /product="gag-pol fusion protein" /protein_id="DAA08815.1" /db_xref="SGD:S000003788" /translation="MESQQLSQHSHISHGSACASVTSKEVHTNQDPLDVSASKTEECE KASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWS FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM TVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNN SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQELTESTVNHTNHS DDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQD NTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVQYGDFYWV SKRYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNE SDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKS APSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSE YTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFS AIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGI PGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLT ASYQSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTE DSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAP MSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKR IIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPD PFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSL EPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLL KMKTWDTDEYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDTGMQS NTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLK KSHYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDL NANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIP KLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRF DLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISD ASYGNQPYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSY LIQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYY IETKKNIADVMTKPLPIKTFKLLTNKWIH" gene 472760..474082 /locus_tag="YJR026W" mRNA 472760..474082 /locus_tag="YJR026W" /product="gag protein" CDS 472760..474082 /locus_tag="YJR026W" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /codon_start=1 /product="gag protein" /protein_id="DAA08816.1" /db_xref="SGD:S000003787" /translation="MESQQLSQHSHISHGSACASVTSKEVHTNQDPLDVSASKTEECE KASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWS FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM TVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNN SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPGTY" mobile_element 478051..483972 /note="YJRWTy1-2; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats" /mobile_element_type="retrotransposon:YJRWTy1-2" /db_xref="SGD:S000007049" repeat_region 478051..478384 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007041" gene 478344..483612 /locus_tag="YJR029W" mRNA 478344..483612 /locus_tag="YJR029W" /product="gag-pol fusion protein" CDS join(478344..479644,479646..483612) /locus_tag="YJR029W" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /codon_start=1 /product="gag-pol fusion protein" /protein_id="DAA08817.1" /db_xref="SGD:S000003790" /translation="MESQQLSQHSHISHGSACASVTSKEVHTNQDPLDVSASKTEECE KASTKANSQQTTTPASSAVPENPHHASPQTAQSHSPQNGPYPQQCMMTQNQANPSGWS FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM TVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNN SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHS DDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQD NTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWV SKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNE SDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKS APSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSE YTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFS AIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGI PGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLT ASYQSFIASNEIQQSDDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTE DSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAP MSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKR IIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPD PFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSL EPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLL KMKTWDTDEYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSGMQS NTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLK KSLYGLKQSGANWYETIKSYLIQQCGMEEVRGWSCVFKNSQVTICLFVDDMVLFSKNL NSNKRIIEKLKMQYDTKIINLGESDEEIQYDILGLEIKYQRGKYMKLGMENSLTEKIP KLNVPLNPKGRKLSAPGQPGLYIDQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRF DLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISD ASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSY LIQELDKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCY IETKKNIADVMTKPLPIKTFKLLTNKWIH" gene 478344..479666 /locus_tag="YJR028W" mRNA 478344..479666 /locus_tag="YJR028W" /product="gag protein" CDS 478344..479666 /locus_tag="YJR028W" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /codon_start=1 /product="gag protein" /protein_id="DAA08818.1" /db_xref="SGD:S000003789" /translation="MESQQLSQHSHISHGSACASVTSKEVHTNQDPLDVSASKTEECE KASTKANSQQTTTPASSAVPENPHHASPQTAQSHSPQNGPYPQQCMMTQNQANPSGWS FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM TVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNN SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPETY" repeat_region 483635..483972 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007042" gene complement(483959..486196) /gene="RBH2" /locus_tag="YJR030C" mRNA complement(483959..486196) /gene="RBH2" /locus_tag="YJR030C" /product="Rbh2p" CDS complement(483959..486196) /gene="RBH2" /locus_tag="YJR030C" /experiment="EXISTENCE:mutant phenotype:GO:0019320 hexose catabolic process [PMID:23185390]" /note="hypothetical protein; expression repressed in carbon limited vs carbon replete chemostat cultures; non-essential gene; contains a PH-like domain; RBH2 has a paralog, RBH1, that arose from the whole genome duplication" /codon_start=1 /product="Rbh2p" /protein_id="DAA08819.1" /db_xref="SGD:S000003791" /translation="MELFNKEEASFETLLKRLLVVCESHSRYHGSSLDPMVKVGHEMR KISGYLRCILRKHAANHDDMSLTQSIVNSYKSLFKDAQILDLYHNLLFGCMHLLLDAN MSYFRMDSQKLFAVLLFKVYYKLRDIFYVTNEVRLGSLISAFVYKFKSCYDFISCNSL KYGSVRDVISGEVSLINLPPIDSNKVINRAYYRLDVKKLAINNKLVEILELDNGEIAI FEVLSEKMPYTLQTIDNLFQSLALGNHDLMNVGRSLLFRPFRSGDLDLIRLDDSGAKL KVPINNSIVLRLTCKDPIQWQEYWKHVIRKLFDSTATKEYKRSGSKISQQVYVRSNNP DYTSPKRNDDMPISSVKISDTIHNGRTLHRSIPLPGSLSSLIETSNEYPDEESLSIMS ERATVSEDSDLDTSLKDIESLSCEKLIELDKSIQVPLSPKYMDTPTLKNIRTASQTFS LESVSPELIESVASEIDDSESIISEDGKDKRDKDLFDPDIDFYKPTLYRRKSSSLLSI FSKNKKNLTIDIPKNHSRSLFSLPGNQQSVTPVSATPHDDNVDETYVSFPLSINTSGG AVYFENDSVKVSLWNGKSWVPLSKDMLCLSLILSGDNETLLIVYKDFEKEKCKLVVKL EPTWKYNRSTAQDVQLRIPSSDFKASVFGTLHDLTLSIRCAQAAKLVNVLQYQLQSSQ TSSLSPSTTTGTLSTVSSSSCFSRNVTRSSTENSELANMKDSSEYISSSLLLSSVKVR QLRNM" gene complement(486586..490812) /gene="GEA1" /locus_tag="YJR031C" mRNA complement(486586..490812) /gene="GEA1" /locus_tag="YJR031C" /product="Arf family guanine nucleotide exchange factor GEA1" CDS complement(486586..490812) /gene="GEA1" /locus_tag="YJR031C" /experiment="EXISTENCE:direct assay:GO:0000137 Golgi cis cisterna [PMID:11294905]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:10430582]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:11294905]" /experiment="EXISTENCE:genetic interaction:GO:0030036 actin cytoskeleton organization [PMID:14668359]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:8945477|PMID:11493664]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11493664]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:20444982]" /note="Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication" /codon_start=1 /product="Arf family guanine nucleotide exchange factor GEA1" /protein_id="DAA08820.1" /db_xref="SGD:S000003792" /translation="MHDVPMETVLAVNPATMIVKECINLCSAMNKQSRDKSQTSVAAL LGGGSDIFLSQSDSFVDSFHNLPTSSYHDPLISGLVQLRLKINDLKGLDSLNALELLK PFLEIVSASSVSGYTTSLALDSLQKVFTLKIINKTFNDIQIAVRETVVALTHCRFEAS KQISDDSVLLKVVTLLRDIITSSFGDYLSDTIIYDVLQTTLSLACNTQRSEVLRKTAE VTIAGITVKLFTKLKLLDPPTKTEKYINDESYTDNNLKDDIIGTTTSDNDLSSTDDDS AVADDNKNEKPVQQVIREQENDEETAEKAENVEPNYGITVIKDYLGLLLSLVMPENRM KHTTSAMKLSLQLINAAIEISGDKFPLYPRLFSLISDPIFKSVLFIIQSSTQYSLLQA TLQLFTSLVVILGDYLPMQIELTLRRIFEILEDTTISGDVSKQKPPAIRELIIEQLSI LWIHSPAFFLQLFVNFDCNLDRSDLSIDFIKELTKFSLPAAAVNTSNNIPPICLEGVL SLIENIYNDLQRFDRAEFVKNQKEIDILKQRDRKTEFILCVETFNEKAKKGIQMLIEK GFIDSDSNRDIASFLFLNNGRLNKKTIGLLLCDPKKTSLLKEFIDLFDFKGLRVDEAI RILLTKFRLPGESQQIERIVEAFSSKYSADQSNDKVELEDKKAGKNGSESMTEDDIIH VQPDADSVFVLSYSIIMLNTDSHNPQVKDHMTFDDYSNNLRGCYNGKDFPRWYLHKIY TSIKVKEIVMPEEHHGNERWFEDAWNNLISSTSVMTEMQRDFTNPISKLAQIDILQYE KAIFSNVRDIILKTLFKIFTVASSDQISLRILDAISKCTFINYYFSFDQSYNDTVLHL GEMTTLAQSSAKAVELDVDSIPLVEIFVEDTGSKISVSNQSIRLGQNFKAQLCTVLYF QIIKEISDPSIVSTRLWNQIVQLILKLFENLLMEPNLPFFTNFHSLLKLPELPLPDPD ISIRKAKMSRSLLSTFASYLKGDEEPSEEDIDFSIKAFECVKASHPLSSVFENNQLVS PKMIETLLSSLVIEKTSENSPYFEQELLFLLEISIILISEASYGQEFGALIADHMINI SNLDGLSKEAIARLASYKMFLVSRFDNPRDILSDLIEHDFLVKNEIFNTKYYESEWGK QVINDLFTHLNDVKYNERALKNVKFWNFLRILISAKDRQFAVYTFLEKYIQNGDIFVD DGNFMNILSLLDEMSCAGAVGTKWEQNYENSVEDGCEAPESNPYRSIIDLSSRSINIT ADLLSTVGRSNSALNKNEIIAAIQGLAHQCLNPCDELGMQALQALENILLSRASQLRT EKVAVDNLLETGLLPIFELDEIQDVKMKRITSILSVLSKIFLGQLVEGVTSNETFLRV LNVFNKYVDDPTVERQLQELIISKREIEKE" gene 491081..492262 /gene="CPR7" /locus_tag="YJR032W" mRNA 491081..492262 /gene="CPR7" /locus_tag="YJR032W" /product="peptidylprolyl isomerase CPR7" CDS 491081..492262 /gene="CPR7" /locus_tag="YJR032W" /EC_number="5.2.1.8" /experiment="EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:10942767]" /experiment="EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:10942767]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:10942767]" /experiment="EXISTENCE:physical interaction:GO:0005829 cytosol [PMID:10942767]" /note="Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; plays a role in determining prion variants" /codon_start=1 /product="peptidylprolyl isomerase CPR7" /protein_id="DAA08821.1" /db_xref="SGD:S000003793" /translation="MIQDPLVYLDISIDKKPIGRIVCKLFREKAPKTTENFYKLCAGD VKSPLKDQQYLSYKGNGFHRVVKNFMIQAGDIVFGTQKDSSSSSVGKGGCSIYADKEE VKTDDESFCYGNFEDENLGEFVEPFTLGMANLGSPNTNNSQFFITTYAAPHLNGKHSI FGQVVHGKSVVRTIENCRVDSDGVPESDVRISDCGVWEKTMGVPLYNASNDQIGGDVY EEYPDDDTHFGDDDFGKALEAANIIKESGTLLFKKKDYSNAFFKYRKSLNYINEYMPE PDVDKERNIQFINLKMKIYLNLSLVLFNLERYDDAIMYATYLLEMDNVPNRDQAKAYY RRGNSYLKKKRLDEALQDYIFCKEKNPDDEVIEQRIEYVNRLIEENKEKTRKNISKFF S" gene complement(492378..496451) /gene="RAV1" /locus_tag="YJR033C" /gene_synonym="SOI3" mRNA complement(492378..496451) /gene="RAV1" /locus_tag="YJR033C" /gene_synonym="SOI3" /product="Rav1p" CDS complement(492378..496451) /gene="RAV1" /locus_tag="YJR033C" /gene_synonym="SOI3" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11283612]" /experiment="EXISTENCE:genetic interaction:GO:0007035 vacuolar acidification [PMID:11844802|PMID:11283612]" /experiment="EXISTENCE:genetic interaction:GO:0043254 regulation of protein-containing complex assembly [PMID:11844802]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:11283612|PMID:11844802]" /experiment="EXISTENCE:mutant phenotype:GO:0043254 regulation of protein-containing complex assembly [PMID:11844802|PMID:11283612]" /experiment="EXISTENCE:mutant phenotype:GO:0045022 early endosome to late endosome transport [PMID:15090613]" /experiment="EXISTENCE:physical interaction:GO:0043254 regulation of protein-containing complex assembly [PMID:11283612]" /experiment="EXISTENCE:physical interaction:GO:0043291 RAVE complex [PMID:11844802|PMID:11283612]" /note="Subunit of RAVE complex (Rav1p, Rav2p, Skp1p); the RAVE complex promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate" /codon_start=1 /product="Rav1p" /protein_id="DAA08822.1" /db_xref="SGD:S000003794" /translation="MSLNFLPGRPNATPQTACQATWQNHTIFAYCSGNNLIILTNKFT RLQTIYTQSDCTAVDINSQNGFIALSFHNRVLIYKPIHQIMQNPKWTQCCQLFHDDTP VNCLRWSSDNELAIGSDFLSFWKIKDNFGVYQPILQWNQKQPKPVYNVIISQDSQLIV SIGKYDCNAKLWKRVSIVGEQAIFNLTMLPHPKPITAMRWKKEPDQVSKNNTASHALY TLCEDKVLRIWSCFEMEKNHTVQIWGEVPLSPTQKFCVIIDNWIIRQTLSVKDSEIFD ISDSDIVILGSMTGEMEVLALNNLSQDPPKPMTKKTISHKKVKKATMLNDTRYLYLPE IQPYDNVKGKLSFLVHDLQGVIRHLLIDILQLINNKTEDLSAALEHKFTGHNKSVQKL VRSSDGEALLTTSRFSENGVWYPQKLNHGVSLRLQNTIQTESPIKFAVVHELGKQVIC LLENGALQAWECPTNRKEDSEQKQSYLRVETRLKEEKKIHPIVMLNTPEPKHSHERHF TALIFSDGSIKAFEVSLTRGIFEVKSDSLDIDGDDIYKISIIDPVHQTFVSNRPLISL ITKKGLTRTYKAIVNYNDRHVQWIKACEINTGIMNCTCIRGSSTGKLCIVNSTGKVMS LWDLNRGVLEYEETFHNPIEDIDWTSTEYGQSIVSIGFTGYALLYTQLRYDYTNNTPS YLPIEKIDITAHTAHNIGDSVWMKNGTFVVASGNQFYIKDKSLDLTDPFTYQSIGSRK ILSNDILHLSSVLNGPLPVYHPQFLIQAIYANKLQLVKELLLRLFLALRKLDFESQDV SNLDSNLGMDPLKYFIAKDRDYPVESFPDPYPCFNKTVSLALTEQLTKTTLPYLTRHQ QITLITVIEAVDEVTKNENIVDYNGVRFLLGVKLFLSHKNIQKSILMRDVSWALHSDN KEILLSSIDRHITSWNRAREYRIAYWIKEQDLVKKFEDIAKYEFSKDDKRDPSRCAIF YLALKKKQILLSLWKMAIGHPEQQKMVRFISNDFTVPRWRTAALKNAFVLLSKHRYMD AAVFFLLTDSLKDCVNVLCKQVHDMDLAIGVCRVYEGDNGPVLGELLTAQMLPETIKE NDRWKASFIYWKLRKQEVAIKALLTAPIDLENNSSIVDKEVCVNRSFLVEDPALLYLY NHLRNRNLKYFIGSLNVEAKIECTLILRVTDILCRMGCNYLAVSLVKNWKFIERNSIP VQKLLKSPTKDRAYSAIGAMASEPISTARMRPSLFDKFGSPSASDIESPNPKLPNSLL DDFLQPPPNSTSSNSLAQSSSSAPRSILDEFVSPSYSQHKENLTPKAPNDSVGETDNS ENRKDKLSKDILDDLSSQKPQKPKKSAITKNLLDDFV" gene 496683..497009 /gene="PET191" /locus_tag="YJR034W" mRNA 496683..497009 /gene="PET191" /locus_tag="YJR034W" /product="Pet191p" CDS 496683..497009 /gene="PET191" /locus_tag="YJR034W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:18503002]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:8381337|PMID:18503002]" /note="Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery" /codon_start=1 /product="Pet191p" /protein_id="DAA08823.1" /db_xref="SGD:S000003795" /translation="MVASCKDQKKAVAICLQRSPCVMIERHNPQECLDNPELNKDLPE LCIAQMKAFLDCKRGIVDMTKRFTGNAPLSTGKYDQQYENLCKGKFDPREEMEKLKLL NSQQKD" gene 497355..500612 /gene="RAD26" /locus_tag="YJR035W" mRNA 497355..500612 /gene="RAD26" /locus_tag="YJR035W" /product="DNA-dependent ATPase RAD26" CDS 497355..500612 /gene="RAD26" /locus_tag="YJR035W" /EC_number="3.6.4.12" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008094 ATP-dependent activity, acting on DNA [PMID:8702468]" /experiment="EXISTENCE:genetic interaction:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:17023424]" /experiment="EXISTENCE:genetic interaction:GO:0006289 nucleotide-excision repair [PMID:17023424]" /experiment="EXISTENCE:mutant phenotype:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:32690696|PMID:7957102]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:23991048]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:23991048]" /note="Protein involved in transcription-coupled nucleotide excision repair; repairs UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein" /codon_start=1 /product="DNA-dependent ATPase RAD26" /protein_id="DAA08824.1" /db_xref="SGD:S000003796" /translation="MEDKEQQDNAKLENNESLKDLGVNVLSQSSLEEKIANDVTNFSN LQSLQQEETRLERSKTALQRYVNKKNHLTRKLNNTTRISVKQNLRDQIKNLQSDDIER VLKDIDDIQSRIKELKEQVDQGAENKGSKEGLQRPGETEKEFLIRTGKITAFGHKAGF SLDTANREYAKNDEQKDEDFEMATEQMVENLTDEDDNLSDQDYQMSGKESEDDEEEEN DDKILKELEDLRFRGQPGEAKDDGDELYYQERLKKWVKQRSCGSQRSSDLPEWRRPHP NIPDAKLNSQFKIPGEIYSLLFNYQKTCVQWLYELYQQNCGGIIGDEMGLGKTIQVIA FIAALHHSGLLTGPVLIVCPATVMKQWCNEFQHWWPPLRTVILHSMGSGMASDQKFKM DENDLENLIMNSKPSDFSYEDWKNSTRTKKALESSYHLDKLIDKVVTDGHILITTYVG LRIHSDKLLKVKWQYAVLDEGHKIRNPDSEISLTCKKLKTHNRIILSGTPIQNNLTEL WSLFDFIFPGKLGTLPVFQQQFVIPINIGGYANATNIQVQTGYKCAVALRDLISPYLL RRVKADVAKDLPQKKEMVLFCKLTKYQRSKYLEFLHSSDLNQIQNGKRNVLFGIDILR KICNHPDLLDRDTKRHNPDYGDPKRSGKMQVVKQLLLLWHKQGYKALLFTQSRQMLDI LEEFISTKDPDLSHLNYLRMDGTTNIKGRQSLVDRFNNESFDVFLLTTRVGGLGVNLT GANRIIIFDPDWNPSTDMQARERAWRIGQKREVSIYRLMVGGSIEEKIYHRQIFKQFL TNRILTDPKQKRFFKIHELHDLFSLGGENGYSTEELNEEVQKHTENLKNSKSEESDDF EQLVNLSGVSKLESFYNGKEKKENSKTEDDRLIEGLLGGESNLETVMSHDSVVNSHAG SSSSNIITKEASRVAIEAVNALRKSRKKITKQYEIGTPTWTGRFGKAGKIRKRDPLKN KLTGSAAILGNITKSQKEASKEARQENYDDGITFARSKEINSNTKTLENIRAYLQKQN NFFSSSVSILNSIGVSLSDKEDVIKVRALLKTIAQFDKERKGWVLDEEFRNNNAS" gene complement(500713..503391) /gene="HUL4" /locus_tag="YJR036C" mRNA complement(500713..503391) /gene="HUL4" /locus_tag="YJR036C" /product="putative E3 ubiquitin-protein ligase HUL4" CDS complement(500713..503391) /gene="HUL4" /locus_tag="YJR036C" /EC_number="2.3.2.26" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0031499 TRAMP complex [PMID:15828860]" /note="Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex" /codon_start=1 /product="putative E3 ubiquitin-protein ligase HUL4" /protein_id="DAA08825.1" /db_xref="SGD:S000003797" /translation="MVSLFDKLNAKKDGRDGSVSKELLSHSVAHTKNRLPKSGRRTSE RSLAASVKDGSCSNSKSNKRNSSASVSGEEDKSCLISLNCLCCGVPLRFPASITKFRC SACQVTVIVKEPEINSNLESSTHISCTLEGLQMVVRRCHDDLQRLKKTGILDKERKGL IFQPVITYLLDRFHDVSILNRSFLVHDGGKNIKMLNYEVLQRFYSILSNLPTRKPYYS MLCCCNDLLKRITINKGENLQILQYRWLLIILNIPTIRTCLIRDRKSKNVFETQQIRA VSYELAKRCIGYLSNLSTKTSQQLIQSLRRTPTDNFSYQVEILNLYINFQFSRLLSNE LSNRTAKNNVKPEDEMRSRLRRHHTTGHEFLSTRPISAQSNDKQGSGFTHPVNNKMKF KFFQYEEDWHIHSAAKLTFIYYVANTRRNGRGALSIQSFYNITLDFIDYKQDFDHWRG VAQKTKMNQLIEEWGNSTTKKCFSFCKYPFILSLGIKISIMEYEIRRIMEHEAEQAFL ISLDKGKSVDVYFKIKVRRDVISHDSLRCIKEHQGDLLKSLRIEFVNEPGIDAGGLRK EWFFLLTKSLFNPMNGLFIYIKESSRSWFAIDPPNFDKSKGKNSQLELYYLFGVVMGL AIFNSTILDLQFPKALYKKLCSEPLSFEDYSELFPETSRNLIKMLNYTEDNFEDVFSL TFETTYRNNNWILNDSKSSKEYVTVELCENGRNVPITQSNKHEFVMKWVEFYLEKSIE PQYNKFVSGFKRVFAECNSIKLFNSEELERLVCGDEEQTKFDFKSLRSVTKYVGGFSD DSRAVCWFWEIIESWDYPLQKKLLQFVTASDRIPATGISTIPFKISLLGSHDSDDLPL AHTCFNEICLWNYSSKKKLELKLLWAINESEGYGFR" gene 503936..507301 /gene="MLO127" /locus_tag="YJR039W" mRNA 503936..507301 /gene="MLO127" /locus_tag="YJR039W" /product="Mlo127p" CDS 503936..507301 /gene="MLO127" /locus_tag="YJR039W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /note="Mitochondrial hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /codon_start=1 /product="Mlo127p" /protein_id="DAA08826.1" /db_xref="SGD:S000003800" /translation="MPAGRIRIAMTDNIIVSEVDGPPDVVKCFIREEDGLEGQSRELV VIGLEYIDVFEGVEQDEARKKLRLRTVGYTMAAFYFKDHTAPNRRFYILLKATGRLDF VNLDYKIVKSLETGIDQVRSEPKFMFQDPLRTALVFNLSCTEIYEISTEDIFCLEETD VKLSYVTSSPIVSIDACINFNDFLDKDVFTLSILTRAHNEVAYKLEACVCVFESKPAK GTKWQRTTNLTFVEEATVSQVLLKSVTNIGHFVFTPWKTYFIKHALSSKQTIDGKTVD KIYQGPGAFGSDNMERIELLQPILADTTLNHLTFTFMTSTAILITCRMNAILSSFEDD TYIWEKALFERLPINGGSSHDHYLAAFFNEKCWILVSPKGHLTVYSVRNEGHSNFVHL GSFLCKSTLYSDLIGNYTKSHLSCGSLHCGQGYLCLKFRSCGDIFASTCMKLLFKSKD SVPRQVYSTRKGIYWADVNNNVYRDSERIDFEINGSFIATKDGTLLKDNTIVTLVPIQ RDNECNYAYVTKQGYLRWSFSKVYYRIQNTGVDLTIDNCFLSAISSKGSFLTVLVLND EITVFDHCNRLKSQKVVFHRLSDLASIFLYEYESTVYIFMSDTEGNLCVMKLATFEIV EEVKICKKKLQFCEVPNSDYFFIYTADTIIFFKPSKIKGRFKIQEVYAPCPISCLIPG EKDGSVVMVTSQGQFYDVLVPGDAGRATLCSKFEKVLKTCLKFITLESSSRYVIVAAL PVANPLQDKYSEIYVYDIKQFKNISAFNFSNLNNDIESIKYENAMISDIIAVPMLKRT ETLGKRKTSELYKEVIFNSCILVSLNLDSIDGIDSKNMNNLLLFSFDEESGFIEFVFG INTGFSISGLHNYYNGCVLVYGEFVQAYQLNYSVHDNKFSIEQVSNRLNISGITITSS IFFDKRKAKMARKQQNIGTWVYLEEMILLDVRKGVMRFNVIHTTDGNIEKVQLQVQPL NLFERDLINSITDTGKMFTGAAAITFKNIRYLLISYGDQKLTLFSLKLDGEEEIDERV YHVAEQVTTINSVRTTDSRMSTFLGESTFMPLFLVSTLSNGCYVIGILHEESDISLHI LSEKKAVFAKRSVQKFLGFLDPQMDDHTVISEI" gene 507746..510085 /gene="GEF1" /locus_tag="YJR040W" /gene_synonym="CLC" mRNA 507746..510085 /gene="GEF1" /locus_tag="YJR040W" /gene_synonym="CLC" /product="Gef1p" CDS 507746..510085 /gene="GEF1" /locus_tag="YJR040W" /gene_synonym="CLC" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:17662057]" /experiment="EXISTENCE:direct assay:GO:0005247 voltage-gated chloride channel activity [PMID:12074596]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:15710404]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:17662057]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:15710404]" /experiment="EXISTENCE:direct assay:GO:0005797 Golgi medial cisterna [PMID:9614122]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17662057]" /experiment="EXISTENCE:mutant phenotype:GO:0006878 intracellular copper ion homeostasis [PMID:9614122|PMID:9520490]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:9520490]" /note="Voltage-gated chloride channel; localized to the golgi, the endosomal system, and plasma membrane; involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism" /codon_start=1 /product="Gef1p" /protein_id="DAA08827.1" /db_xref="SGD:S000003801" /translation="MPTTYVPINQPIGDGEDVIDTNRFTNIPETQNFDQFVTIDKIAE ENRPLSVDSDREFLNSKYRHYREVIWDRAKTFITLSSTAIVIGCIAGFLQVFTETLVN WKTGHCQRNWLLNKSFCCNGVVNEVTSTSNLLLKRQEFECEAQGLWIAWKGHVSPFII FMLLSVLFALISTLLVKYVAPMATGSGISEIKVWVSGFEYNKEFLGFLTLVIKSVALP LAISSGLSVGKEGPSVHYATCCGYLLTKWLLRDTLTYSSQYEYITAASGAGVAVAFGA PIGGVLFGLEEIASANRFNSSTLWKSYYVALVAITTLKYIDPFRNGRVILFNVTYDRD WKVQEIPIFIALGIFGGLYGKYISKWNINFIHFRKMYLSSWPVQEVLFLATLTALISY FNEFLKLDMTESMGILFHECVKNDNTSTFSHRLCQLDENTHAFEFLKIFTSLCFATVI RALLVVVSYGARVPAGIFVPSMAVGATFGRAVSLLVERFISGPSVITPGAYAFLGAAA TLSGITNLTLTVVVIMFELTGAFMYIIPLMIVVAITRIILSTSGISGGIADQMIMVNG FPYLEDEQDEEEEETLEKYTAEQLMSSKLITINETIYLSELESLLYDSASEYSVHGFP ITKDEDKFEKEKRCIGYVLKRHLASKIMMQSVNSTKAQTTLVYFNKSNEELGHRENCI GFKDIMNESPISVKKAVPVTLLFRMFKELGCKTIIVEESGILKGLVTAKDILRFKRIK YREVHGAKFTYNEALDRRCWSVIHFIIKRFTTNRNGNVI" gene complement(510239..513763) /gene="URB2" /locus_tag="YJR041C" /gene_synonym="NPA2" mRNA complement(510239..513763) /gene="URB2" /locus_tag="YJR041C" /gene_synonym="NPA2" /product="Urb2p" CDS complement(510239..513763) /gene="URB2" /locus_tag="YJR041C" /gene_synonym="NPA2" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15226434|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0016072 rRNA metabolic process [PMID:15242642]" /experiment="EXISTENCE:physical interaction:GO:0042254 ribosome biogenesis [PMID:15226434]" /note="Protein required for normal metabolism of the rRNA primary transcript; nucleolar protein; proposed to be involved in ribosome biogenesis" /codon_start=1 /product="ribosome biogenesis protein URB2" /protein_id="DAA08828.1" /db_xref="SGD:S000003802" /translation="MGDLTEELSIPDNAQDLSKLLRSTSTKPHQIAEIVSKFDKLETY FPKKEIFVLDLLIDRLNNGNLDDFKTSEHTWIIFTRLLDAINDPISIKKLLKKLKTVP VMIRTFFLWPKDKLLTRSVSFIKAFFAINDYLIVNFSVEESFQLLEHAINGLSSCPTT DFALSYLQDACNLTHVDNITTTDNKIATCYCKHMLLPSLRYFAQTKNSASSNQSFIRL SHFMGKFLLQPRIDYMKLNKKFVQENASEITDDMAYYYFATFVTFLSKDNFAQLEVIF TILGAKKPSLECRFLNLLSESKKTVSQEFLEALLLEMLASTDESGVLSLIPIILKLDI EVAIKHIFRLLELIQLENLNDPLFSSHIWDLIIQSHANARELSDFFAKINEYCSRKGP DSYFLINHPAYVKSITKQLFTLSSLQWKNLLQALLDQVNHDSTNRVPLYLIRICLEGL SEGASRATLDEVKPILSQVFTLESFNNSLQWDLKYHIMEVYDDIVPAEELEKIDYVLS SNIFDTTSADVEELFFYCFKLREYISFDLSDAKKKFMRHFEILDEERKSNLSYSVVSK FATLVNNNFTREQISSLIDSLLLNSTNLSSLLKNDDIFEETNITYALINKLASSYHQT FALEALIQIPIQCINKNVRVALINNLTCESFCLDSATRECLLHLLSSPTFKSNIETNF YELCEKTIMSPEMAISETGDEKKEIEDKISIFEKVWTNHLSQAKEPVSEKFLESGYDI VKQSMSLSNGDSKLIIAGFTIAKFLKPDNKHRDIQGMAISYAVKILENYSENFESETI PLFRISMSTLYKIITTGQGDISKHKSRILDIFSKIMLRYHSKKVYHAPEEQEMFLVHS LLTENKLEYIFAEYLNIEHTDKCDSALGFCLEESLKQGPDAFNRLLWNSAKSFSTISQ PCAEKFVRVFIIMSKRIARDNNLGHHLFVIALLEAYTYCDIEKFGYKSYLLLFNAIKE FLVSKPWLFSQYCIEMLLPFCLKTLAFIVNHESTDEINEGFINIIEVIDHMLLVHRFK FSNRHHLFNSVLCQILEIIAIHDGTLCANSADAVARLITNYCEPYNVSNAQNGQKNNL SSKISLIKQSIRKNVLVVLTKYIQLSITTQFSLNIKKSLQPGIHAIFDILSQNELNQL NAFLDTPGKQYFKALYLQYKKVGKWRED" gene 514055..516289 /gene="NUP85" /locus_tag="YJR042W" /gene_synonym="RAT9" mRNA 514055..516289 /gene="NUP85" /locus_tag="YJR042W" /gene_synonym="RAT9" /product="Nup85p" CDS 514055..516289 /gene="NUP85" /locus_tag="YJR042W" /gene_synonym="RAT9" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0031080 nuclear pore outer ring [PMID:11823431|PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11071906]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:8816998|PMID:8565072]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:12730220]" /experiment="EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:22331846]" /experiment="EXISTENCE:mutant phenotype:GO:0051664 nuclear pore localization [PMID:8816998|PMID:8565072]" /note="Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75" /codon_start=1 /product="Nup85p" /protein_id="DAA08829.1" /db_xref="SGD:S000003803" /translation="MTIDDSNRLLMDVDQFDFLDDGTAQLSNNKTDEEEQLYKRDPVS GAILVPMTVNDQPIEKNGDKMPLKFKLGPLSYQNMAFITAKDKYKLYPVRIPRLDTSK EFSAYVSGLFEIYRDLGDDRVFNVPTIGVVNSNFAKEHNATVNLAMEAILNELEVFIG RVKDQDGRVNRFYELEESLTVLNCLRTMYFILDGQDVEENRSEFIESLLNWINRSDGE PDEEYIEQVFSVKDSTAGKKVFETQYFWKLLNQLVLRGLLSQAIGCIERSDLLPYLSD TCAVSFDAVSDSIELLKQYPKDSSSTFREWKNLVLKLSQAFGSSATDISGELRDYIED FLLVIGGNQRKILQYSRTWYESFCGFLLYYIPSLELSAEYLQMSLEANVVDITNDWEQ PCVDIISGKIHSILPVMESLDSCTAAFTAMICEAKGLIENIFEGEKNSDDYSNEDNEM LEDLFSYRNGMASYMLNSFAFELCSLGDKELWPVAIGLIALSATGTRSAKKMVIAELL PHYPFVTNDDIEWMLSICVEWRLPEIAKEIYTTLGNQMLSAHNIIESIANFSRAGKYE LVKSYSWLLFEASCMEGQKLDDPVLNAIVSKNSPAEDDVIIPQDILDCVVTNSMRQTL APYAVLSQFYELRDREDWGQALRLLLLLIEFPYLPKHYLVLLVAKFLYPIFLLDDKKL MDEDSVATVIEVIETKWDDADEKSSNLYETIIEADKSLPSSMATLLKNLRKKLNFKLC QAFM" gene complement(516461..517513) /gene="POL32" /locus_tag="YJR043C" /gene_synonym="REV5" mRNA complement(516461..517513) /gene="POL32" /locus_tag="YJR043C" /gene_synonym="REV5" /product="DNA polymerase delta subunit POL32" CDS complement(516461..517513) /gene="POL32" /locus_tag="YJR043C" /gene_synonym="REV5" /experiment="EXISTENCE:direct assay:GO:0000510 H3-H4 histone complex chaperone activity [PMID:38713623]" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:18635534]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006278 RNA-templated DNA biosynthetic process [PMID:17429354]" /experiment="EXISTENCE:direct assay:GO:0016035 zeta DNA polymerase complex [PMID:23066099|PMID:22711820]" /experiment="EXISTENCE:direct assay:GO:0043137 DNA replication, removal of RNA primer [PMID:16837458]" /experiment="EXISTENCE:mutant phenotype:GO:0000510 H3-H4 histone complex chaperone activity [PMID:38713623]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:17671506]" /experiment="EXISTENCE:mutant phenotype:GO:0006277 DNA amplification [PMID:23271978]" /experiment="EXISTENCE:mutant phenotype:GO:0042276 error-prone translesion synthesis [PMID:17681555]" /note="Third subunit of DNA polymerase delta; involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; parental H3-H4 histone chaperone that mediates transfer of parental histones to the lagging strand via Pol1p during DNA replication; forms a complex with Rev3p, Rev7p and Pol31p; interacts with Hys2p, PCNA (Pol30p), and Pol1p" /codon_start=1 /product="DNA polymerase delta subunit POL32" /protein_id="DAA08830.1" /db_xref="SGD:S000003804" /translation="MDQKASYFINEKLFTEVKPVLFTDLIHHLKIGPSMAKKLMFDYY KQTTNAKYNCVVICCYKDQTIKIIHDLSNIPQQDSIIDCFIYAFNPMDSFIPYYDIID QKDCLTIKNSYELKVSESSKIIERTKTLEEKSKPLVRPTARSKTTPEETTGRKSKSKD MGLRSTALLAKMKKDRDDKETSRQNELRKRKEENLQKINKQNPEREAQMKELNNLFVE DDLDTEEVNGGSKPNSPKETDSNDKDKNNDDLEDLLETTAEDSLMDVPKIQQTKPSET EHSKEPKSEEEPSSFIDEDGYIVTKRPATSTPPRKPSPVVKRALSSSKKQETPSSNKR LKKQGTLESFFKRKAK" gene complement(517813..517884) /gene="IMT3" /locus_tag="YNCJ0022C" tRNA complement(517813..517884) /gene="IMT3" /locus_tag="YNCJ0022C" /product="tRNA-Met" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006413 translational initiation [PMID:9023104]" /experiment="EXISTENCE:direct assay:GO:0016282 eukaryotic 43S preinitiation complex [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0033290 eukaryotic 48S preinitiation complex [PMID:17242201]" /experiment="EXISTENCE:direct assay:GO:0071074 eukaryotic initiation factor eIF2 binding [PMID:14698289]" /note="Methionine initiator tRNA (tRNA-Met); predicted by tRNAscan-SE analysis; one of four initiator methionine tRNAs in yeast that are functional for translation" /db_xref="SGD:S000006663" repeat_region 517959..518099 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007043" gene complement(518763..519185) /gene="VPS55" /locus_tag="YJR044C" mRNA complement(518763..519185) /gene="VPS55" /locus_tag="YJR044C" /product="Vps55p" CDS complement(518763..519185) /gene="VPS55" /locus_tag="YJR044C" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:12006663]" /experiment="EXISTENCE:direct assay:GO:0034424 Vps55/Vps68 complex [PMID:18216282]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:18216282]" /experiment="EXISTENCE:physical interaction:GO:0034424 Vps55/Vps68 complex [PMID:18216282]" /note="Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP)" /codon_start=1 /product="Vps55p" /protein_id="DAA08831.1" /db_xref="SGD:S000003805" /translation="MMEFKVSPLTKIISLSGFLALGFLLVILSCALFHNYYPLFDILI FLLAPIPNTIFNAGNKYHTSDFMSDSSNTGQDLAHFLTGMLVTSGIALPVVFYHCQLI GHLSCIMCMIGGLIIYSSIVIFKWFFKKDFNEDDSLFG" gene complement(519638..521602) /gene="SSC1" /locus_tag="YJR045C" /gene_synonym="ENS1" mRNA complement(519638..521602) /gene="SSC1" /locus_tag="YJR045C" /gene_synonym="ENS1" /product="Hsp70 family ATPase SSC1" CDS complement(519638..521602) /gene="SSC1" /locus_tag="YJR045C" /gene_synonym="ENS1" /EC_number="3.6.4.10" /experiment="EXISTENCE:direct assay:GO:0001405 PAM complex, Tim23 associated import motor [PMID:14638855|PMID:14517234]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:11914276|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:7935837]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:11096111]" /experiment="EXISTENCE:direct assay:GO:0030150 protein import into mitochondrial matrix [PMID:8654364]" /experiment="EXISTENCE:direct assay:GO:0030234 enzyme regulator activity [PMID:10464305]" /experiment="EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:9973563]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15692048]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:10779357]" /experiment="EXISTENCE:mutant phenotype:GO:0042026 protein refolding [PMID:16460754]" /experiment="EXISTENCE:mutant phenotype:GO:0043335 protein unfolding [PMID:8408192]" /note="Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication" /codon_start=1 /product="Hsp70 family ATPase SSC1" /protein_id="DAA08832.1" /db_xref="SGD:S000003806" /translation="MLAAKNILNRSSLSSSFRIATRLQSTKVQGSVIGIDLGTTNSAV AIMEGKVPKIIENAEGSRTTPSVVAFTKEGERLVGIPAKRQAVVNPENTLFATKRLIG RRFEDAEVQRDIKQVPYKIVKHSNGDAWVEARGQTYSPAQIGGFVLNKMKETAEAYLG KPVKNAVVTVPAYFNDSQRQATKDAGQIVGLNVLRVVNEPTAAALAYGLEKSDSKVVA VFDLGGGTFDISILDIDNGVFEVKSTNGDTHLGGEDFDIYLLREIVSRFKTETGIDLE NDRMAIQRIREAAEKAKIELSSTVSTEINLPFITADASGPKHINMKFSRAQFETLTAP LVKRTVDPVKKALKDAGLSTSDISEVLLVGGMSRMPKVVETVKSLFGKDPSKAVNPDE AVAIGAAVQGAVLSGEVTDVLLLDVTPLSLGIETLGGVFTRLIPRNTTIPTKKSQIFS TAAAGQTSVEIRVFQGERELVRDNKLIGNFTLAGIPPAPKGVPQIEVTFDIDADGIIN VSARDKATNKDSSITVAGSSGLSENEIEQMVNDAEKFKSQDEARKQAIETANKADQLA NDTENSLKEFEGKVDKAEAQKVRDQITSLKELVARVQGGEEVNAEELKTKTEELQTSS MKLFEQLYKNDSNNNNNNNGNNAESGETKQ" gene 522048..523862 /gene="TAH11" /locus_tag="YJR046W" /gene_synonym="CDT1" /gene_synonym="SID2" mRNA 522048..523862 /gene="TAH11" /locus_tag="YJR046W" /gene_synonym="CDT1" /gene_synonym="SID2" /product="Tah11p" CDS 522048..523862 /gene="TAH11" /locus_tag="YJR046W" /gene_synonym="CDT1" /gene_synonym="SID2" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11836525]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11836525]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:11967159]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0005656 nuclear pre-replicative complex [PMID:11967159]" /note="DNA replication licensing factor; required for pre-replication complex assembly" /codon_start=1 /product="Tah11p" /protein_id="DAA08833.1" /db_xref="SGD:S000003807" /translation="MSGTANSRRKEVLRVPVIDLNRVSDEEQLLPVVRAILLQHDTFL LKNYANKAVLDALLAGLTTKDLPDTSQGFDANFTGTLPLEDDVWLEQYIFDTDPQLRF DRKCRNESLCSIYSRLFKLGLFFAQLCVKSVVSSAELQDCISTSHYATKLTRYFNDNG STHDGADAGATVLPTGDDFQYLFERDYVTFLPTGVLTIFPCAKAIRYKPSTMATTDNS WVSIDEPDCLLFHTGTLLARWSQGMHTTSPLQIDPRANIVSLTIWPPLTTPISSKGEG TIANHLLEQQIKAFPKVAQQYYPRELSILRLQDAMKFVKELFTVCETVLSLNALSRST GVPPELHVLLPQISSMMKRKIVQDDILKLLTIWSDAYVVELNSRGELTMNLPKRDNLT TLTNKSRTLAFVERAESWYQQVIASKDEIMTDVPAFKINKRRSSSNSKTVLSSKVQTK SSNANALNNSRYLANSKENFMYKEKMPDSQANLMDRLRERERRSAALLSQRQKRYQQF LAMKMTQVFDILFSLTRGQPYTETYLSSLIVDSLQDSNNPIGTKEASEILAGLQGILP MDISVHQVDGGLKVYRWNSLDKNRFSKLLQIHKSKQQD" gene complement(524012..524093) /locus_tag="YNCJ0023C" tRNA complement(524012..524093) /locus_tag="YNCJ0023C" /product="tRNA-Ser" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /experiment="EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]" /experiment="EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]" /note="Serine tRNA (tRNA-Ser), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006727" gene complement(524908..525381) /gene="ANB1" /locus_tag="YJR047C" /gene_synonym="HYP1" /gene_synonym="TIF51B" mRNA complement(524908..525381) /gene="ANB1" /locus_tag="YJR047C" /gene_synonym="HYP1" /gene_synonym="TIF51B" /product="translation elongation factor eIF-5A" CDS complement(524908..525381) /gene="ANB1" /locus_tag="YJR047C" /gene_synonym="HYP1" /gene_synonym="TIF51B" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:27196944]" /experiment="EXISTENCE:genetic interaction:GO:0006452 translational frameshifting [PMID:19424157]" /experiment="EXISTENCE:genetic interaction:GO:0045901 positive regulation of translational elongation [PMID:19424157]" /note="Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication; human EIF5A complements the inviability of the yeast hyp2 anb1 double null mutant" /codon_start=1 /product="translation elongation factor eIF-5A" /protein_id="DAA08834.1" /db_xref="SGD:S000003808" /translation="MSDEEHTFENADAGASATYPMQCSALRKNGFVVIKGRPCKIVDM STSKTGKHGHAKVHLVTLDIFTGKKLEDLSPSTHNLEVPFVKRSEYQLLDIDDGYLSL MTMDGETKDDVKAPEGELGDSMQAAFDEGKDLMVTIISAMGEEAAISFKEAPRSD" gene 526335..526664 /gene="CYC1" /locus_tag="YJR048W" mRNA 526335..526664 /gene="CYC1" /locus_tag="YJR048W" /product="cytochrome c isoform 1" CDS 526335..526664 /gene="CYC1" /locus_tag="YJR048W" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:9866716]" /experiment="EXISTENCE:direct assay:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:7851399]" /experiment="EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:7851399]" /experiment="EXISTENCE:direct assay:GO:0009055 electron transfer activity [PMID:18975895|PMID:7851399]" /experiment="EXISTENCE:direct assay:GO:1901612 cardiolipin binding [PMID:30182710]" /note="Cytochrome c, isoform 1; also known as iso-1-cytochrome c; electron carrier of mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication; human homolog CYC1 can complement yeast null mutant; mutations in human CYC1 cause insulin-responsive hyperglycemia" /codon_start=1 /product="cytochrome c isoform 1" /protein_id="DAA08835.1" /db_xref="SGD:S000003809" /translation="MTEFKAGSAKKGATLFKTRCLQCHTVEKGGPHKVGPNLHGIFGR HSGQAEGYSYTDANIKKNVLWDENNMSEYLTNPKKYIPGTKMAFGGLKKEKDRNDLIT YLKKACE" gene complement(526884..528476) /gene="UTR1" /locus_tag="YJR049C" mRNA complement(526884..528476) /gene="UTR1" /locus_tag="YJR049C" /product="NADH/NAD(+) kinase" CDS complement(526884..528476) /gene="UTR1" /locus_tag="YJR049C" /EC_number="2.7.1.23" /experiment="EXISTENCE:direct assay:GO:0003951 NAD+ kinase activity [PMID:11425472]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006741 NADP biosynthetic process [PMID:15978040|PMID:11425472]" /experiment="EXISTENCE:direct assay:GO:0042736 NADH kinase activity [PMID:15978040]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:8662826]" /note="ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication" /codon_start=1 /product="NADH/NAD(+) kinase" /protein_id="DAA08836.1" /db_xref="SGD:S000003810" /translation="MKENDMNNGVDKWVNEEDGRNDHHNNNNNLMKKAMMNNEQIDRT QDIDNAKEMLRKISSESSSRRSSLLNKDSSLVNGNANSGGGTSINGTRGSSKSSNTHF QYASTAYGVRMLSKDISNTKVELDVENLMIVTKLNDVSLYFLTRELVEWVLVHFPRVT VYVDSELKNSKKFAAGELCEDSKCRESRIKYWTKDFIREHDVFFDLVVTLGGDGTVLF VSSIFQRHVPPVMSFSLGSLGFLTNFKFEHFREDLPRIMNHKIKTNLRLRLECTIYRR HRPEVDPNTGKKICVVEKLSTHHILNEVTIDRGPSPFLSMLELYGDGSLMTVAQADGL IAATPTGSTAYSLSAGGSLVCPTVNAIALTPICPHALSFRPIILPESINLKVKVSMKS RAPAWAAFDGKDRIELQKGDFITICASPYAFPTVEASPDEFINSISRQLNWNVREQQK SFTHILSQKNQEKYAHEANKVRNQAEPLEVIRDKYSLEADATKENNNGSDDESDDESV NCEACKLKPSSVPKPSQARFSV" gene 528697..529404 /gene="ISY1" /locus_tag="YJR050W" /gene_synonym="NTC30" /gene_synonym="UTR3" mRNA 528697..529404 /gene="ISY1" /locus_tag="YJR050W" /gene_synonym="NTC30" /gene_synonym="UTR3" /product="Isy1p" CDS 528697..529404 /gene="ISY1" /locus_tag="YJR050W" /gene_synonym="NTC30" /gene_synonym="UTR3" /experiment="EXISTENCE:direct assay:GO:0000974 Prp19 complex [PMID:11018040]" /experiment="EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:10094305|PMID:11018040]" /experiment="EXISTENCE:direct assay:GO:0071007 U2-type catalytic step 2 spliceosome [PMID:10094305]" /experiment="EXISTENCE:direct assay:GO:0071014 post-mRNA release spliceosomal complex [PMID:10094305]" /experiment="EXISTENCE:direct assay:GO:0071020 post-spliceosomal complex [PMID:10094305]" /experiment="EXISTENCE:genetic interaction:GO:0000384 first spliceosomal transesterification activity [PMID:16103217]" /experiment="EXISTENCE:mutant phenotype:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:10094305]" /experiment="EXISTENCE:mutant phenotype:GO:0000389 mRNA 3'-splice site recognition [PMID:16103217]" /note="Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs; interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles" /codon_start=1 /product="Isy1p" /protein_id="DAA08837.1" /db_xref="SGD:S000003811" /translation="MSRNVDKANSVLVRFQEQQAESAGGYKDYSRYQRPRNVSKVKSI KEANEWKRQVSKEIKQKSTRIYDPSLNEMQIAELNDELNNLFKEWKRWQWHIDHTLME KKTKRKRLEDSHVLMNSGKLINGKRYFGRALELPEVKEWLKQSQRQNDGGSINTKCIP KDRNDFYYHGKVTAALTEFEANWTSILKAHYNVPVNEDEEEMSRQTQEIHVPTLADME HWLVQRRKKKLMDELNL" gene 529861..531366 /gene="OSM1" /locus_tag="YJR051W" mRNA 529861..531366 /gene="OSM1" /locus_tag="YJR051W" /product="fumarate reductase" CDS 529861..531366 /gene="OSM1" /locus_tag="YJR051W" /EC_number="1.3.1.6" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:9587404|PMID:25378625|PM ID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:25378625]" /experiment="EXISTENCE:direct assay:GO:0016156 fumarate reductase (NADH) activity [PMID:9587404]" /experiment="EXISTENCE:mutant phenotype:GO:0034975 protein folding in endoplasmic reticulum [PMID:25378625]" /experiment="EXISTENCE:mutant phenotype:GO:0046443 FAD metabolic process [PMID:17345583]" /note="Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; acts as electron acceptor in mitochondrial intermembrane space; has two translation start sites, one at the annotated start codon which produces an ER-targeted form required for anaerobic growth, and one at codon 32 which produces a mitochondrially-targeted form; OSM1 has a paralog, FRD1, that arose from the whole genome duplication" /codon_start=1 /product="fumarate reductase" /protein_id="DAA08838.1" /db_xref="SGD:S000003812" /translation="MIRSVRRVFIYVSIFVLIIVLKRTLSGTDQTSMKQPVVVIGSGL AGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMDTPELFL KDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQLGGHSVPRTHRSSGK LPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYMDENGNRK IMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAELIDMD QVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTNELSTRDTVTMEIQ SKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELVT ELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVI KKNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFGKTAADNIAKLY" repeat_region complement(531516..531675) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007032" gene 531828..531898 /gene="SUF23" /locus_tag="YNCJ0024W" tRNA 531828..531898 /gene="SUF23" /locus_tag="YNCJ0024W" /product="tRNA-Gly" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /experiment="EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]" /experiment="EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]" /note="Glycine tRNA (tRNA-Gly); can mutate to suppress +1 frameshift mutations" /db_xref="SGD:S000006584" gene 532062..533759 /gene="RAD7" /locus_tag="YJR052W" mRNA 532062..533759 /gene="RAD7" /locus_tag="YJR052W" /product="UV-damaged DNA-binding protein RAD7" CDS 532062..533759 /gene="RAD7" /locus_tag="YJR052W" /experiment="EXISTENCE:direct assay:GO:0000113 nucleotide-excision repair factor 4 complex [PMID:9497356]" /experiment="EXISTENCE:direct assay:GO:0000715 nucleotide-excision repair, DNA damage recognition [PMID:15177043]" /experiment="EXISTENCE:direct assay:GO:0003684 damaged DNA binding [PMID:9497356]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:16675952]" /experiment="EXISTENCE:direct assay:GO:0008094 ATP-dependent activity, acting on DNA [PMID:9497356]" /experiment="EXISTENCE:direct assay:GO:0008104 protein localization [PMID:15226437]" /experiment="EXISTENCE:direct assay:GO:0031463 Cul3-RING ubiquitin ligase complex [PMID:16675952]" /experiment="EXISTENCE:mutant phenotype:GO:0000715 nucleotide-excision repair, DNA damage recognition [PMID:15177043]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:16675952]" /note="Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad16p) during NER; required for repair of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex" /codon_start=1 /product="UV-damaged DNA-binding protein RAD7" /protein_id="DAA08839.1" /db_xref="SGD:S000003813" /translation="MYRSRNRPKRGGENEVKGPNSALTQFLREEGISAENIKQKWYQR QSKKQEDATDEKKGKAEDDSFTAEISRVVEDEEIDEIGTGSGTETERAQVSYDARMKL VPADSDEEEYETSHISDTPVSLSSANDRESLTKKRQNTAKIIQNRRRKRKRAADLLDR RVNKVSSLQSLCITKISENISKWQKEADESSKLVFNKLRDVLGGVSTANLNNLAKALS KNRALNDHTLQLFLKTDLKRLTFSDCSKISFDGYKTLAIFSPHLTELSLQMCGQLNHE SLLYIAEKLPNLKSLNLDGPFLINEDTWEKFFVIMKGRLEEFHISNTHRFTDKSLSNL LINCGSTLVSLGLSRLDSISNYALLPQYLVNDEFHSLCIEYPFNEEDVNDEIIINLLG QIGRTLRKLVLNGCIDLTDSMIINGLTAFIPEKCPLEVLSLEESDQITTDSLSYFFSK VELNNLIECSFRRCLQLGDMAIIELLLNGARDSLRSLNLNSLKELTKEAFVALACPNL TYLDLGFVRCVDDSVIQMLGEQNPNLTVIDVFGDNLVTEKATMRPGLTLIGRQSDSI" gene 534027..535751 /gene="BFA1" /locus_tag="YJR053W" /gene_synonym="IBD1" mRNA 534027..535751 /gene="BFA1" /locus_tag="YJR053W" /gene_synonym="IBD1" /product="Bfa1p" CDS 534027..535751 /gene="BFA1" /locus_tag="YJR053W" /gene_synonym="IBD1" /experiment="EXISTENCE:direct assay:GO:0005092 GDP-dissociation inhibitor activity [PMID:19948498]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:18667533|PMID:12048186|PMID:16682821]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:10220406|PMID:15147270]" /experiment="EXISTENCE:direct assay:GO:1990334 Bfa1-Bub2 complex [PMID:25658911]" /experiment="EXISTENCE:mutant phenotype:GO:0001100 negative regulation of exit from mitosis [PMID:18667533|PMID:15147270]" /experiment="EXISTENCE:mutant phenotype:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:16039591]" /experiment="EXISTENCE:physical interaction:GO:1990334 Bfa1-Bub2 complex [PMID:11493673]" /note="Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p; contributes to GAP activity, inactivating Tem1 by stimulating GTP hydrolysis following damage or misalignment of the mitotic spindle; functions as a guanine-nucleotide exchange inhibitor (GDI) for Tem1p; involved in multiple cell cycle checkpoint pathways that control mitotic exit; required when telomeres are damaged, but not for all types of chromosomal DNA damage; phosphorylated by the Polo-like kinase Cdc5p" /codon_start=1 /product="Bfa1p" /protein_id="DAA08840.1" /db_xref="SGD:S000003814" /translation="MSIRPLTLNGLDEPETSFEELNTTLPRFQSHETLTLEENVPPLS TSTYIPPPSSVGTSDTGTVFSNSTSAFWSNKQADDDQDMEVDQDDEFLNDFQEFQNKK DDFDDAIKTNFHLRNGCRTGPFKNDIFAEEFDRKLSLEDKPRLKQPRSMMELKPKRKL SNSVTSRNLRSGNSVRFKKSMPNLALVNPAIREEEEDEEREREDQREFNYKIDNDTQD TILAKFSSDDEGDFLTGFEELEGEAIDETISSNDKESADHPRFLKKSSSSLPLKISPA QYDIVKHDELLTPGLHRRQRDWNTQQELDSFKEKRSVRHCSNQNVQLNGPAKIKTIKQ QIDHNTPMKKGSMIYNPKTMKWEGNENVLSKFSDVDTANRKALLIKNKLQRDADSKKQ KYSDLQHARATSRNQKVIGNMILDEQNLRWVSVSEEEADPFAGIPEINLPPVGKSMKK RSSSPFLRSKSQVNTPFVSNDNDGVYQSTAAQARLRKYHSMRTLNGTTETPEISSTFH LSSRALEKFYHEENRWCKKLASWFIPRDETIISVDEETIMDESTVNSKRKSYMYEIRN MVINSTKD" gene 536056..537549 /gene="KCH1" /locus_tag="YJR054W" mRNA 536056..537549 /gene="KCH1" /locus_tag="YJR054W" /product="Kch1p" CDS 536056..537549 /gene="KCH1" /locus_tag="YJR054W" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:23204190]" /experiment="EXISTENCE:direct assay:GO:0005937 mating projection [PMID:23204190]" /experiment="EXISTENCE:direct assay:GO:0015079 potassium ion transmembrane transporter activity [PMID:23204190]" /experiment="EXISTENCE:direct assay:GO:0071805 potassium ion transmembrane transport [PMID:23204190]" /note="Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; localized to sites of polarized growth; member of a fungal-specific gene family; potential Cdc28p substrate; KCH1 has a paralog, PRM6, that arose from the whole genome duplication" /codon_start=1 /product="Kch1p" /protein_id="DAA08841.1" /db_xref="SGD:S000003815" /translation="MFNHDWKYSINSKTFADLNIELFRNHKFKTVLNYIIGVVGWNGL KLALFVSDIYTCIKLLAFNSWSNNIIKPYLPFKISKWLFSGCILASIVLLIWEAIAGM RIYKTGNISLTYVNNFSRNLNSVLNYSKFCVYNMIERKGFRQKMTFFTFFQLKDCIRL IFTDTPRQVINGLTLWSVLVTVNKNEDLGDLESFTGLINKIKNIGQTNHEEAVILSLM LFSFIIWALFVFKFLLAVICSIFVYYKIINDQEYSGLREYICVTVSENVDELVERQRK KENDDTIYKTGLLESQTFDDFKEVENKIETSFNDTSYASNNDSMIELIERRPEYKSQD VCGPIPTMKKTETMESFVDNGNPQYTTRFSAILDSPYINSYESNDIKKAKIQSRSVNT PKYEDLSSSDIFNKIHSAGQLKSTTSMEFHGPLDSMPNTTNNIRNFNSNSSRPRPPPL QTKSSINSKADSNDNGRIYTPMKAYFREPDLPRKGLLEDEDRTYNYT" repeat_region complement(537741..538041) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007033" repeat_region 538103..538434 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007044" gene 538555..538626 /gene="HSX1" /locus_tag="YNCJ0025W" tRNA 538555..538626 /gene="HSX1" /locus_tag="YNCJ0025W" /product="tRNA-Arg" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Arginine tRNA (tRNA-Arg), predicted by tRNAscan-SE analysis; low abundance tRNA required for growth on nonfermentable carbon sources at high temperatures, for synthesis of heat shock protein Ssc1p, and for Ty1 retrotransposition through the regulation of translational frameshifting" /db_xref="SGD:S000006707" gene 538772..539266 /gene="HIT1" /locus_tag="YJR055W" mRNA 538772..539266 /gene="HIT1" /locus_tag="YJR055W" /product="Hit1p" CDS 538772..539266 /gene="HIT1" /locus_tag="YJR055W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:25170085]" /experiment="EXISTENCE:mutant phenotype:GO:0000492 box C/D snoRNP assembly [PMID:25170085]" /note="Protein involved in C/D snoRNP assembly; critical for formation of small nucleolar ribonucleoprotein complexes that are required for rRNA processing and 2'-O-methylation; regulates abundance of Rsa1p; required for growth at high temperature; mutations in human homolog ZNHIT3 cause PEHO syndrome, a ribosomopathy characterized by extreme cerebellar atrophy" /codon_start=1 /product="Hit1p" /protein_id="DAA08842.1" /db_xref="SGD:S000003816" /translation="MVSSAVKCGICRGVDGKYKCPKCGVRYCSLKCYKDAAKHVHKES EQPRAGTEANVEVVNNDKIINSSLAMNKTLKTKAFDDIYQNSAELQELLKYNTVKFHL AKVYRILSSTVNDGSSGKMNSDLQKELAVNYLNTLRYGGIHYNEAIEEFCQILLDKLN AVKK" rep_origin 540546..540780 /note="ARS1018; Autonomously Replicating Sequence" /db_xref="SGD:S000028455" repeat_region 540766..541087 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007045" repeat_region complement(541095..541427) /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007034" gene 541508..541579 /locus_tag="YNCJ0026W" tRNA 541508..541579 /locus_tag="YNCJ0026W" /product="tRNA-Asp" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Aspartate tRNA (tRNA-Asp), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006539" gene complement(541792..542502) /locus_tag="YJR056C" mRNA complement(541792..542502) /locus_tag="YJR056C" /product="hypothetical protein" CDS complement(541792..542502) /locus_tag="YJR056C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08843.1" /db_xref="SGD:S000003817" /translation="MEQMHSLESSLPPEQPPTKQAIESLNLELSQEFKLAANAVTRLY RVANEKNSLTKHQGYLTCLDDILCALDSNVTADELRAWCYKRRNDILSNSQDKSLNPV KERERKLNKFSENQHRENEAHKEPFEKDSAVKYNFSFNESNGDLSNINENIAPKFRLS MPPLSVEHPPRNASRIKSWKARTINHGRGDTRNLNDITGLGHERERDRENTHYEKKPK LDSDSEVDIRSFRQDMDL" gene complement(542956..543044) /gene="SUP4" /locus_tag="YNCJ0027C" tRNA complement(join(542956..542991,543006..543044)) /gene="SUP4" /locus_tag="YNCJ0027C" /product="tRNA-Tyr" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Tyrosine tRNA (tRNA-Tyr), predicted by tRNAscan-SE analysis; can mutate to suppress ochre nonsense mutations" /db_xref="SGD:S000006782" repeat_region 543448..543770 /note="Ty1 LTR" /rpt_type=long_terminal_repeat /db_xref="SGD:S000007046" gene 544062..544712 /gene="CDC8" /locus_tag="YJR057W" mRNA 544062..544712 /gene="CDC8" /locus_tag="YJR057W" /product="bifunctional thymidylate/uridylate kinase" CDS 544062..544712 /gene="CDC8" /locus_tag="YJR057W" /EC_number="2.7.4.9" /experiment="EXISTENCE:direct assay:GO:0004550 nucleoside diphosphate kinase activity [PMID:19540237]" /experiment="EXISTENCE:direct assay:GO:0004798 thymidylate kinase activity [PMID:19540237|PMID:6094555|PMID:6088527]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:6094555]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:6094555]" /experiment="EXISTENCE:direct assay:GO:0006227 dUDP biosynthetic process [PMID:6094555]" /experiment="EXISTENCE:direct assay:GO:0006233 dTDP biosynthetic process [PMID:6094555|PMID:6088527|PMID:19540237]" /experiment="EXISTENCE:direct assay:GO:0006235 dTTP biosynthetic process [PMID:19540237]" /experiment="EXISTENCE:direct assay:GO:0009041 UMP/dUMP kinase activity [PMID:6094555]" /experiment="EXISTENCE:genetic interaction:GO:0004798 thymidylate kinase activity [PMID:6091111]" /experiment="EXISTENCE:genetic interaction:GO:0006233 dTDP biosynthetic process [PMID:6091111]" /experiment="EXISTENCE:mutant phenotype:GO:0004550 nucleoside diphosphate kinase activity [PMID:19540237]" /experiment="EXISTENCE:mutant phenotype:GO:0004798 thymidylate kinase activity [PMID:6088527|PMID:6091111|PMID:19540237]" /experiment="EXISTENCE:mutant phenotype:GO:0006233 dTDP biosynthetic process [PMID:6088527|PMID:19540237|PMID:6091111]" /experiment="EXISTENCE:mutant phenotype:GO:0006235 dTTP biosynthetic process [PMID:19540237]" /note="Nucleoside monophosphate and nucleoside diphosphate kinase; functions in the de novo biosynthesis of pyrimidine deoxyribonucleotides; thymidylate/uridylate kinase that converts nucleoside monophosphates, dTMP and dUMP to nucleoside diphosphates, dTDP and dUDP; nucleoside diphosphate kinase that converts nucleoside diphosphates, dTDP and dUDP to dTTP and dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe tmp1; human homolog DTYMK can complement the cdc8 null mutant" /codon_start=1 /product="bifunctional thymidylate/uridylate kinase" /protein_id="DAA08844.1" /db_xref="SGD:S000003818" /translation="MMGRGKLILIEGLDRTGKTTQCNILYKKLQPNCKLLKFPERSTR IGGLINEYLTDDSFQLSDQAIHLLFSANRWEIVDKIKKDLLEGKNIVMDRYVYSGVAY SAAKGTNGMDLDWCLQPDVGLLKPDLTLFLSTQDVDNNAEKSGFGDERYETVKFQEKV KQTFMKLLDKEIRKGDESITIVDVTNKGIQEVEALIWQIVEPVLSTHIDHDKFSFF" gene complement(544732..545175) /gene="APS2" /locus_tag="YJR058C" /gene_synonym="YAP17" mRNA complement(544732..545175) /gene="APS2" /locus_tag="YJR058C" /gene_synonym="YAP17" /product="Aps2p" CDS complement(544732..545175) /gene="APS2" /locus_tag="YJR058C" /gene_synonym="YAP17" /experiment="EXISTENCE:curator inference:GO:0006886 intracellular protein transport [PMID:10564262]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030122 AP-2 adaptor complex [PMID:10564262]" /experiment="EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:8157009]" /experiment="EXISTENCE:physical interaction:GO:0030122 AP-2 adaptor complex [PMID:10564262]" /note="Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex" /codon_start=1 /product="Aps2p" /protein_id="DAA08845.1" /db_xref="SGD:S000003819" /translation="MAVQFILCFNKQGVVRLVRWFDVHSSDPQRSQDAIAQIYRLISS RDHKHQSNFVEFSDSTKLIYRRYAGLYFVMGVDLLDDEPIYLCHIHLFVEVLDAFFGN VCELDIVFNFYKVYMIMDEMFIGGEIQEISKDMLLERLSILDRLD" gene 545787..548243 /gene="PTK2" /locus_tag="YJR059W" /gene_synonym="STK2" mRNA 545787..548243 /gene="PTK2" /locus_tag="YJR059W" /gene_synonym="STK2" /product="protein kinase PTK2" CDS 545787..548243 /gene="PTK2" /locus_tag="YJR059W" /gene_synonym="STK2" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894|PMID:16510118]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12206772]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12206772]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16510118]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:12518319]" /experiment="EXISTENCE:mutant phenotype:GO:0000296 spermine transport [PMID:8920934]" /experiment="EXISTENCE:mutant phenotype:GO:0006873 intracellular monoatomic ion homeostasis [PMID:11003661]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0015847 putrescine transport [PMID:9154797]" /experiment="EXISTENCE:mutant phenotype:GO:0015848 spermidine transport [PMID:9154797]" /note="Serine/threonine protein kinase; involved in regulation of ion transport across plasma membrane; carboxyl terminus is essential for glucose-dependent Pma1p activation via phosphorylation of Pma1p-Ser899; enhances spermine uptake; PTK2 has a paralog, PTK1, that arose from the whole genome duplication" /codon_start=1 /product="protein kinase PTK2" /protein_id="DAA08846.1" /db_xref="SGD:S000003820" /translation="MAGNGKDKEVDKSPSVSTLKLLGKRLFNSSSHTDNSSLLLSAEQ LGNGRSLRKRPTSPSISGSGSGGNSPSSSAGARQRSASLHRRKNNASVGFSNGSVSSH KSSVALQDLIKHNNNPYLNSPSDILGTGTGIASTRDRDRAVLDREKEKERARNKERNT HHAGLPQRSNSMASHHFPNENIVYNPYGISPNHARPDTAFADTLNTNKENDLSFYMHD GNSKIRMLPLPIANPNDFLPEDMKQYSVHLTDNFVFDTDNKPIGSGGSSEVRKVKSSY RQKDVYALKKLNMIYHESPEKFYKRCSKEFIIAKHLSHNVHITNTFYLLKVPTTTYTT RGWGFIMELGVKDLFQLMERTGWKNVPFNEKYCLFKQVAQGIKFCHDNGIAHRDLKPE NVLISKEGICKLTDFGISDWYHVIPHDYTSPVKTCQGMIGSPPYTPPEVMYFDAKKHY PEKFQKPYNPLAMDSYALGIMLITMINNIIPFIDSCNTDARFREFEVSYDNFINHQNP HFRDKGCHKPGPGSEYSLARNFKNTDATRIAWRLADPNPATRYTMDDLFNDPFFQQIE TCVEPNDDDLVRVPELRKSTSTNDFSENSLDAPHDQEVIHTSNPFLKKETLTSKPRSM LEIAESPSLKQKSKVKDSAKTKTHDVGDEGGNESTKPKQQDKKENLKKDEVKNGDKDK VIEEATTTNVDSILEKPTPTSTKVEDNLSEDDSTMKELKSMLNSTPTTPTHNGPTPLP AKAGTQLDKRMSDLSLKSETPASTKNFSAPNVSSSSNSLRSLGSPSVSSSKKKKVIHH HLDITNSVTNMSSVSAFISR" gene 548759..549814 /gene="CBF1" /locus_tag="YJR060W" /gene_synonym="CEP1" /gene_synonym="CPF1" mRNA 548759..549814 /gene="CBF1" /locus_tag="YJR060W" /gene_synonym="CEP1" /gene_synonym="CPF1" /product="Cbf1p" CDS 548759..549814 /gene="CBF1" /locus_tag="YJR060W" /gene_synonym="CEP1" /gene_synonym="CPF1" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:9407032]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:8665859|PMID:7891681|PMID:9894911]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:15302821]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:7891681]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:15111622]" /experiment="EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:11222754|PMID:9407032|PMID:2249662|PMID:2057354]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12820973]" /experiment="EXISTENCE:direct assay:GO:0089713 Cbf1-Met4-Met28 complex [PMID:8665859|PMID:9171357]" /experiment="EXISTENCE:genetic interaction:GO:0007059 chromosome segregation [PMID:9584087]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10921921|PMID:15302821|PMID:22696683]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:21131275|PMID:7891681|PMID:2249662]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:7891681]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:2185892|PMID:2057354|PMID:2188087]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17351075|PMID:7891681|PMID:22696683|PMID:20935143|PM ID:7601277]" /experiment="EXISTENCE:mutant phenotype:GO:0061431 cellular response to methionine [PMID:7891681]" /experiment="EXISTENCE:mutant phenotype:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:20935143]" /experiment="EXISTENCE:mutant phenotype:GO:1900059 positive regulation of sulfate assimilation [PMID:7601277|PMID:7891681]" /experiment="EXISTENCE:mutant phenotype:GO:1900060 negative regulation of ceramide biosynthetic process [PMID:15302821]" /experiment="EXISTENCE:mutant phenotype:GO:1900090 positive regulation of inositol biosynthetic process [PMID:17351075|PMID:20935143]" /experiment="EXISTENCE:physical interaction:GO:0000776 kinetochore [PMID:11070082]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:8665859]" /note="Basic helix-loop-helix (bHLH) protein; forms homodimer to bind E-box consensus sequence CACGTG present at MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins, required for chromosome segregation; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="Cbf1p" /protein_id="DAA08847.1" /db_xref="SGD:S000003821" /translation="MNSLANNNKLSTEDEEIHSARKRGYNEEQNYSEARKKQRDQGLL SQESNDGNIDSALLSEGATLKGTQSQYESGLTSNKDEKGSDDEDASVAEAAVAATVNY TDLIQGQEDSSDAHTSNQTNANGEHKDSLNGERAITPSNEGVKPNTSLEGMTSSPMES TQQSKNDMLIPLAEHDRGPEHQQDDEDNDDADIDLKKDISMQPGRRGRKPTTLATTDE WKKQRKDSHKEVERRRRENINTAINVLSDLLPVRESSKAAILACAAEYIQKLKETDEA NIEKWTLQKLLSEQNASQLASANEKLQEELGNAYKEIEYMKRVLRKEGIEYEDMHTHK KQENERKSTRSDNPHEA" gene 550511..553318 /gene="MNN14" /locus_tag="YJR061W" mRNA 550511..553318 /gene="MNN14" /locus_tag="YJR061W" /product="Mnn14p" CDS 550511..553318 /gene="MNN14" /locus_tag="YJR061W" /experiment="EXISTENCE:genetic interaction:GO:0006491 N-glycan processing [PMID:28101612]" /note="Protein required for N-glycan mannosylphosphorylation; non-essential gene; transcription repressed by Rm101p; MNN14 has a paralog, MNN4, that arose from the whole genome duplication" /codon_start=1 /product="Mnn14p" /protein_id="DAA08848.1" /db_xref="SGD:S000003822" /translation="MMLSLRRFSMYVLRSLRLHFKKIIITLLTIQLLFITIFVLGGRS SIIDGNWKSFMALFFKPLAYTNRNNNHASFDLRSKDNVAKLYEKMNFDTSGKWIDTYT LKNNLLTVKMGPEKGQVLDSVDELRYYDNDPRLVWSVLLDHLLESDSNEYAFSWYDWA NFDSTNKLIALRHTNISCQFVCEGAFDKNVLEMVESEVQEPLFVTNRNKYDESLWYNR VRKVVDSNSVQQAIHDHCMNNDAYSNGTPFELPFIISEISERLRPEVYDLQAKNHLLY SNFTPLSLTVLDSDKDAYRINLKTTDSSKSNIVQTNLLQNYIKRHRNEMVNGDLIFNH TSMFEKFLHHGSTKKRKLDVEALDKTIYAGEYLELSPSDFQFNAKERIIELETRLRSE GLPSHDTHYLRSLKTSVNTSPALQQKYFAEASDITDATADGHHRDRRFFSIGHNLLND PQEFEARLNSLIRNFQKFVKANGLISWLSHGTLYGYLYDGLKFPWDVDHDLQMPIKHL HYLSQYFNQSLILEDPREGNGRFLLDVGSAITVGVHGNGENNIDARFIDIDSGIYIDI TGLSVSSDAAKQYMSKFVEEESSGESFSALIEDYKFDENDYFDEVDGREGLAKYTIHE LMEWVNSHPDDFTDAEKNLVTKTYKKELAISRSDYAEKDLSPKQRYLVNEKYNLYNCR NQHFSSLNIISPLRNTMFSGVSAFVPNRPIATLNNEYKVPAKYGLLSFQGKVYLPEFR YWFSFADMKKFANLQLKEPKITRLESPLNDLKFSDISLLITNILKCGFHSVFASLFNS FDSTVYRLKELEIQYDPSLSEEEKSSLLKTLRRGMSKKIKSPEKDPIIYIYERKLWEN VEKLLNASNIYNIASQVEKEKGKEFVERSQQVYERNFDGFRLPDGGNSKTVNDLNSKG LNLFGDNKKTSNNIFGSDQKY" gene complement(553476..554849) /gene="NTA1" /locus_tag="YJR062C" /gene_synonym="DEA1" mRNA complement(553476..554849) /gene="NTA1" /locus_tag="YJR062C" /gene_synonym="DEA1" /product="amidase" CDS complement(553476..554849) /gene="NTA1" /locus_tag="YJR062C" /gene_synonym="DEA1" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008418 protein-N-terminal asparagine amidohydrolase activity [PMID:7744855|PMID:23218487]" /experiment="EXISTENCE:direct assay:GO:0070773 protein-N-terminal glutamine amidohydrolase activity [PMID:23218487]" /experiment="EXISTENCE:mutant phenotype:GO:0008418 protein-N-terminal asparagine amidohydrolase activity [PMID:7744855]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:7744855]" /experiment="EXISTENCE:mutant phenotype:GO:0031365 N-terminal protein amino acid modification [PMID:7744855]" /experiment="EXISTENCE:mutant phenotype:GO:0070773 protein-N-terminal glutamine amidohydrolase activity [PMID:7744855]" /note="Amidase; removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation" /codon_start=1 /product="amidase" /protein_id="DAA08849.1" /db_xref="SGD:S000003823" /translation="MLIDAIHGAKMSTKLLVSLKVLVIQLNPQIGQVDQTIKRTWSIL DKVTKSATYVKPDIILFPEFALTGYSFHARKDILPYVTKKDEGPSFELAKSISEKFQC YTIIGYPEDDDEQKLYNSALVVNPQGEQIFNYRKTFLYDTEMNWDCEENPEGFQTFPM DFSKCAKLSNEDSYNRDVTLKASIGICMDLSPYKFMAPFNHFEFSSFCVDNNVELILC PMAWLNSTSITDKQTLHNNSLLEAAKNKIAFALKEQGLPLAGSQGIYQLKIGDSQRTP RVPSDDSTSEYKDMDEPDMSNVNYWILRFFPFLYFKSRINWFKNSSLIESILGKTRMP LDHEYYKDGKHKEDTIDLLDSEEVIKDTVLEKTFLGTSLGQPWKFQGKNAILVLANRC GTEDGTTIFAGSSGIYKFNGKKPKGSQDDDESSLDSLNESVELLGNLGKGLEGAILRE VQFEVFR" gene 555195..555572 /gene="RPA12" /locus_tag="YJR063W" /gene_synonym="RRN4" mRNA 555195..555572 /gene="RPA12" /locus_tag="YJR063W" /gene_synonym="RRN4" /product="DNA-directed RNA polymerase I core subunit RPA12" CDS 555195..555572 /gene="RPA12" /locus_tag="YJR063W" /gene_synonym="RRN4" /experiment="EXISTENCE:direct assay:GO:0001054 RNA polymerase I activity [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969|PMID:8417319]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:genetic interaction:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:9121426|PMID:1871118]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:27637775]" /experiment="EXISTENCE:mutant phenotype:GO:0006363 termination of RNA polymerase I transcription [PMID:18413718|PMID:15073335]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:27637775]" /note="RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism" /codon_start=1 /product="DNA-directed RNA polymerase I core subunit RPA12" /protein_id="DAA08850.1" /db_xref="SGD:S000003824" /translation="MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSN LKVVTTTADDAFPSSLRAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLR SADEGATVFYTCTSCGYKFRTNN" gene 555914..557602 /gene="CCT5" /locus_tag="YJR064W" /gene_synonym="TCP5" mRNA 555914..557602 /gene="CCT5" /locus_tag="YJR064W" /gene_synonym="TCP5" /product="chaperonin-containing T-complex subunit CCT5" CDS 555914..557602 /gene="CCT5" /locus_tag="YJR064W" /gene_synonym="TCP5" /experiment="EXISTENCE:direct assay:GO:0005832 chaperonin-containing T-complex [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16762366]" /experiment="EXISTENCE:physical interaction:GO:0005832 chaperonin-containing T-complex [PMID:15704212]" /note="Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo" /codon_start=1 /product="chaperonin-containing T-complex subunit CCT5" /protein_id="DAA08851.1" /db_xref="SGD:S000003825" /translation="MAARPQQPPMEMPDLSNAIVAQDEMGRPFIIVKDQGNKKRQHGL EAKKSHILAARSVASIIKTSLGPRGLDKILISPDGEITITNDGATILSQMELDNEIAK LLVQLSKSQDDEIGDGTTGVVVLASALLDQALELIQKGIHPIKIANGFDEAAKLAISK LEETCDDISASNDELFRDFLLRAAKTSLGSKIVSKDHDRFAEMAVEAVINVMDKDRKD VDFDLIKMQGRVGGSISDSKLINGVILDKDFSHPQMPKCVLPKEGSDGVKLAILTCPF EPPKPKTKHKLDISSVEEYQKLQTYEQDKFKEMIDDVKKAGADVVICQWGFDDEANHL LLQNDLPAVRWVGGQELEHIAISTNGRIVPRFQDLSKDKLGTCSRIYEQEFGTTKDRM LIIEQSKETKTVTCFVRGSNKMIVDEAERALHDSLCVVRNLVKDSRVVYGGGAAEVTM SLAVSEEADKQRGIDQYAFRGFAQALDTIPMTLAENSGLDPIGTLSTLKSKQLKEKIS NIGVDCLGYGSNDMKELFVVDPFIGKKQQILLATQLCRMILKIDNVIISGKDEY" gene complement(557809..559158) /gene="ARP3" /locus_tag="YJR065C" /gene_synonym="ACT4" mRNA complement(557809..559158) /gene="ARP3" /locus_tag="YJR065C" /gene_synonym="ACT4" /product="actin-related protein 3" CDS complement(557809..559158) /gene="ARP3" /locus_tag="YJR065C" /gene_synonym="ACT4" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:15657399]" /experiment="EXISTENCE:direct assay:GO:0005885 Arp2/3 protein complex [PMID:10377407]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:9210376]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:15657399]" /experiment="EXISTENCE:mutant phenotype:GO:0034314 Arp2/3 complex-mediated actin nucleation [PMID:16862144]" /experiment="EXISTENCE:mutant phenotype:GO:0044396 actin cortical patch organization [PMID:15534003|PMID:10377407]" /note="Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity" /codon_start=1 /product="actin-related protein 3" /protein_id="DAA08852.1" /db_xref="SGD:S000003826" /translation="MSYLNNPAVVMDNGTGLTKLGFAGNDSPSWVFPTAIATAAPSNT KKSSGVGAPSAVSNEASYFGNSTSATNFNGATGGLLSNNLSGKRGTEDLDFYIGNEAL VASQGPSYSLSYPIRHGQVENWDHMERFWENSIFKYLRTEPEDHFFLLTEPPLNPPEN REQVAEIFFESFNCAGLYIAVQAVLALAASWTSSKVTDRSLTGTVIDSGDGVTHVIPV AEGYVIGSAIKNIPIAGRDITLFIQSLLRERGEADTSLRTAEKIKQEYCYVCPDIVKE FNKFDKDPSKFAQFVVENQEKTRRKVVDIGYERFLAPEIFFNPEIASSDFLTPLPTVV DQTIQACPIDVRKGLYNNIVLSGGSTMFKDFGRRLQRDLKSIVNNRIAQSELLSGTKS TGVDVSVISHRKQRNAVWFGGSLLAQTAEFKGYCHTKKDYEEYGPEIVRNFSLFNMV" gene 559416..566828 /gene="TOR1" /locus_tag="YJR066W" /gene_synonym="DRR1" mRNA 559416..566828 /gene="TOR1" /locus_tag="YJR066W" /gene_synonym="DRR1" /product="phosphatidylinositol kinase-related protein kinase TOR1" CDS 559416..566828 /gene="TOR1" /locus_tag="YJR066W" /gene_synonym="DRR1" /EC_number="2.7.11.1" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:12719473]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:18723607|PMID:25046117|PMID:19748353|PMID:12719473|P MID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:38127619|PMID:26582391]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16900101]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18723607|PMID:16900101]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10973982]" /experiment="EXISTENCE:direct assay:GO:0010008 endosome membrane [PMID:12719473]" /experiment="EXISTENCE:direct assay:GO:0018105 peptidyl-serine phosphorylation [PMID:26582391]" /experiment="EXISTENCE:genetic interaction:GO:0006995 cellular response to nitrogen starvation [PMID:9461583]" /experiment="EXISTENCE:genetic interaction:GO:0010507 negative regulation of autophagy [PMID:9461583]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:27922823]" /experiment="EXISTENCE:genetic interaction:GO:0034605 cellular response to heat [PMID:27922823]" /experiment="EXISTENCE:genetic interaction:GO:1905356 regulation of snRNA pseudouridine synthesis [PMID:27268497]" /experiment="EXISTENCE:mutant phenotype:GO:0004672 protein kinase activity [PMID:10329624]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:8741837]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:17698581]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:14736892]" /experiment="EXISTENCE:mutant phenotype:GO:0031929 TOR signaling [PMID:8186460|PMID:12719473]" /experiment="EXISTENCE:mutant phenotype:GO:0031930 mitochondria-nucleus signaling pathway [PMID:11997479]" /experiment="EXISTENCE:mutant phenotype:GO:0034976 response to endoplasmic reticulum stress [PMID:31144305]" /experiment="EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:10198052]" /experiment="EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:16900101]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:9096347]" /experiment="EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:8741837]" /experiment="EXISTENCE:mutant phenotype:GO:0090153 regulation of sphingolipid biosynthetic process [PMID:23363605]" /experiment="EXISTENCE:physical interaction:GO:0031931 TORC1 complex [PMID:12408816]" /note="PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; indole-3-acetic acid, an ATP-competitive TORC1 inhibitor, accumulates upon entry into stationary phase; malonyl-CoA is a direct ATP-competitive inhibitor of TORC1; TOR1 has a paralog, TOR2, that arose from the whole genome duplication" /codon_start=1 /product="phosphatidylinositol kinase-related protein kinase TOR1" /protein_id="DAA08853.1" /db_xref="SGD:S000003827" /translation="MEPHEEQIWKSKLLKAANNDMDMDRNVPLAPNLNVNMNMKMNAS RNGDEFGLTSSRFDGVVIGSNGDVNFKPILEKIFRELTSDYKEERKLASISLFDLLVS LEHELSIEEFQAVSNDINNKILELVHTKKTSTRVGAVLSIDTLISFYAYTERLPNETS RLAGYLRGLIPSNDVEVMRLAAKTLGKLAVPGGTYTSDFVEFEIKSCLEWLTASTEKN SFSSSKPDHAKHAALLIITALAENCPYLLYQYLNSILDNIWRALRDPHLVIRIDASIT LAKCLSTLRNRDPQLTSQWVQRLATSCEYGFQVNTLECIHASLLVYKEILFLKDPFLN QVFDQMCLNCIAYENHKAKMIREKIYQIVPLLASFNPQLFAGKYLHQIMDNYLEILTN APANKIPHLKDDKPQILISIGDIAYEVGPDIAPYVKQILDYIEHDLQTKFKFRKKFEN EIFYCIGRLAVPLGPVLGKLLNRNILDLMFKCPLSDYMQETFQILTERIPSLGPKIND ELLNLVCSTLSGTPFIQPGSPMEIPSFSRERAREWRNKNILQKTGESNDDNNDIKIII QAFRMLKNIKSRFSLVEFVRIVALSYIEHTDPRVRKLAALTSCEIYVKDNICKQTSLH SLNTVSEVLSKLLAITIADPLQDIRLEVLKNLNPCFDPQLAQPDNLRLLFTALHDESF NIQSVAMELVGRLSSVNPAYVIPSIRKILLELLTKLKFSTSSREKEETASLLCTLIRS SKDVAKPYIEPLLNVLLPKFQDTSSTVASTALRTIGELSVVGGEDMKIYLKDLFPLII KTFQDQSNSFKREAALKALGQLAASSGYVIDPLLDYPELLGILVNILKTENSQNIRRQ TVTLIGILGAIDPYRQKEREVTSTTDISTEQNAPPIDIALLMQGMSPSNDEYYTTVVI HCLLKILKDPSLSSYHTAVIQAIMHIFQTLGLKCVSFLDQIIPTILDVMRTCSQSLLE FYFQQLCSLIIIVRQHIRPHVDSIFQAIKDFSSVAKLQITLVSVIEAISKALEGEFKR LVPLTLTLFLVILENDKSSDKVLSRRVLRLLESFGPNLEGYSHLITPKIVQMAEFTSG NLQRSAIITIGKLAKDVDLFEMSSRIVHSLLRVLSSTTSDELSKVIMNTLSLLLIQMG TSFAIFIPVINEVLMKKHIQHTIYDDLTNRILNNDVLPTKILEANTTDYKPAEQMEAA DAGVAKLPINQSVLKSAWNSSQQRTKEDWQEWSKRLSIQLLKESPSHALRACSNLASM YYPLAKELFNTAFACVWTELYSQYQEDLIGSLCIALSSPLNPPEIHQTLLNLVEFMEH DDKALPIPTQSLGEYAERCHAYAKALHYKEIKFIKEPENSTIESLISINNQLNQTDAA IGILKHAQQHHSLQLKETWFEKLERWEDALHAYNEREKAGDTSVSVTLGKMRSLHALG EWEQLSQLAARKWKVSKLQTKKLIAPLAAGAAWGLGEWDMLEQYISVMKPKSPDKEFF DAILYLHKNDYDNASKHILNARDLLVTEISALINESYNRAYSVIVRTQIITEFEEIIK YKQLPPNSEKKLHYQNLWTKRLLGCQKNVDLWQRVLRVRSLVIKPKQDLQIWIKFANL CRKSGRMRLANKALNMLLEGGNDPSLPNTFKAPPPVVYAQLKYIWATGAYKEALNHLI GFTSRLAHDLGLDPNNMIAQSVKLSSASTAPYVEEYTKLLARCFLKQGEWRIATQPNW RNTNPDAILGSYLLATHFDKNWYKAWHNWALANFEVISMVQEETKLNGGKNDDDDDTA VNNDNVRIDGSILGSGSLTINGNRYPLELIQRHVVPAIKGFFHSISLLETSCLQDTLR LLTLLFNFGGIKEVSQAMYEGFNLMKIENWLEVLPQLISRIHQPDPTVSNSLLSLLSD LGKAHPQALVYPLTVAIKSESVSRQKAALSIIEKIRIHSPVLVNQAELVSHELIRVAV LWHELWYEGLEDASRQFFVEHNIEKMFSTLEPLHKHLGNEPQTLSEVSFQKSFGRDLN DAYEWLNNYKKSKDINNLNQAWDIYYNVFRKITRQIPQLQTLDLQHVSPQLLATHDLE LAVPGTYFPGKPTIRIAKFEPLFSVISSKQRPRKFSIKGSDGKDYKYVLKGHEDIRQD SLVMQLFGLVNTLLKNDSECFKRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREH RDAKKIPLNIEHWVMLQMAPDYENLTLLQKIEVFTYALDNTKGQDLYKILWLKSRSSE TWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILRE KYPEKVPFRLTRMLTYAMEVSGIEGSFRITCENVMRVLRDNKESLMAILEAFALDPLI HWGFDLPPQKLTEQTGIPLPLINPSELLRKGAITVEEAANMEAEQQNETKNARAMLVL RRITDKLTGNDIKRFNELDVPEQVDKLIQQATSIERLCQHYIGWCPFW" gene complement(567019..567444) /gene="YAE1" /locus_tag="YJR067C" mRNA complement(567019..567444) /gene="YAE1" /locus_tag="YJR067C" /product="Yae1p" CDS complement(567019..567444) /gene="YAE1" /locus_tag="YJR067C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:26182403]" /experiment="EXISTENCE:direct assay:GO:0062092 Yae1-Lto1 complex [PMID:26182403]" /experiment="EXISTENCE:mutant phenotype:GO:0106035 protein maturation by [4Fe-4S] cluster transfer [PMID:26182403]" /note="Substrate-specific adaptor protein involved in apo-Rli1p maturation; subunit of the Yae1-Lto1 complex, recruiting apo-Rli1p to the CIA targeting complex, facilitating the insertion of an Fe/S cluster by the Fe-S biosynthetic machinery; deca-GX3 motif crucial for complex formation; essential for aerobic but not anaerobic growth; homolog of human YAE1D1, which is overexpressed in oral cancers; co-expression of YAE1D1 and LTO1 homolog ORAOV1 restores growth and Rli1p maturation after YAE1 depletion" /codon_start=1 /product="Yae1p" /protein_id="DAA08854.1" /db_xref="SGD:S000003828" /translation="MSNTWDDVWASDSDVETERSPDLVKLRENHSKRGYLDGIVSSKE EKLQEGFNDGFPTGAKLGKQVGIIMGILLGLRTRFGDEDEDLSKAYIDAQKELRINKV LSKSIFDPNFDLQEKHPLITKWTDIANTYCEKYHVPSIQ" gene 567643..568704 /gene="RFC2" /locus_tag="YJR068W" mRNA 567643..568704 /gene="RFC2" /locus_tag="YJR068W" /product="replication factor C subunit 2" CDS 567643..568704 /gene="RFC2" /locus_tag="YJR068W" /experiment="EXISTENCE:direct assay:GO:0003689 DNA clamp loader activity [PMID:8995429|PMID:12604797]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23613772]" /experiment="EXISTENCE:direct assay:GO:0005663 DNA replication factor C complex [PMID:8202350]" /experiment="EXISTENCE:direct assay:GO:0006272 leading strand elongation [PMID:1346062]" /experiment="EXISTENCE:direct assay:GO:0031389 Rad17 RFC-like complex [PMID:12604797|PMID:10660302]" /experiment="EXISTENCE:mutant phenotype:GO:0000076 DNA replication checkpoint signaling [PMID:9671499]" /experiment="EXISTENCE:physical interaction:GO:0007062 sister chromatid cohesion [PMID:11389843]" /experiment="EXISTENCE:physical interaction:GO:0031389 Rad17 RFC-like complex [PMID:10660302]" /experiment="EXISTENCE:physical interaction:GO:0031390 Ctf18 RFC-like complex [PMID:11389843]" /experiment="EXISTENCE:physical interaction:GO:0031391 Elg1 RFC-like complex [PMID:12912927]" /note="Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon" /codon_start=1 /product="replication factor C subunit 2" /protein_id="DAA08855.1" /db_xref="SGD:S000003829" /translation="MFEGFGPNKKRKISKLAAEQSLAQQPWVEKYRPKNLDEVTAQDH AVTVLKKTLKSANLPHMLFYGPPGTGKTSTILALTKELYGPDLMKSRILELNASDERG ISIVREKVKNFARLTVSKPSKHDLENYPCPPYKIIILDEADSMTADAQSALRRTMETY SGVTRFCLICNYVTRIIDPLASRCSKFRFKALDASNAIDRLRFISEQENVKCDDGVLE RILDISAGDLRRGITLLQSASKGAQYLGDGKNITSTQVEELAGVVPHDILIEIVEKVK SGDFDEIKKYVNTFMKSGWSAASVVNQLHEYYITNDNFDTNFKNQISWLLFTTDSRLN NGTNEHIQLLNLLVKISQL" gene complement(568806..569399) /gene="HAM1" /locus_tag="YJR069C" mRNA complement(568806..569399) /gene="HAM1" /locus_tag="YJR069C" /product="nucleoside triphosphate pyrophosphohydrolase HAM1" CDS complement(568806..569399) /gene="HAM1" /locus_tag="YJR069C" /EC_number="3.6.1.9" /experiment="EXISTENCE:direct assay:GO:0004170 dUTP diphosphatase activity [PMID:17899088]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008828 dATP diphosphatase activity [PMID:22531138]" /experiment="EXISTENCE:direct assay:GO:0009213 pyrimidine deoxyribonucleoside triphosphate catabolic process [PMID:22531138|PMID:17899088]" /experiment="EXISTENCE:direct assay:GO:0009217 purine deoxyribonucleoside triphosphate catabolic process [PMID:17090528|PMID:17899088|PMID:22531138]" /experiment="EXISTENCE:direct assay:GO:0035870 dITP diphosphatase activity [PMID:17090528|PMID:22531138]" /experiment="EXISTENCE:direct assay:GO:0036217 dGTP diphosphatase activity [PMID:22531138|PMID:17090528]" /experiment="EXISTENCE:direct assay:GO:0036218 dTTP diphosphatase activity [PMID:22531138]" /experiment="EXISTENCE:direct assay:GO:0036219 GTP diphosphatase activity [PMID:22531138]" /experiment="EXISTENCE:direct assay:GO:0036220 ITP diphosphatase activity [PMID:22531138|PMID:17899088]" /experiment="EXISTENCE:direct assay:GO:0036221 UTP diphosphatase activity [PMID:17899088]" /experiment="EXISTENCE:direct assay:GO:0036222 XTP diphosphatase activity [PMID:22531138]" /experiment="EXISTENCE:direct assay:GO:0047840 dCTP diphosphatase activity [PMID:22531138]" /experiment="EXISTENCE:mutant phenotype:GO:0009213 pyrimidine deoxyribonucleoside triphosphate catabolic process [PMID:17899088]" /experiment="EXISTENCE:mutant phenotype:GO:0009217 purine deoxyribonucleoside triphosphate catabolic process [PMID:22308425]" /note="Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA" /codon_start=1 /product="nucleoside triphosphate pyrophosphohydrolase HAM1" /protein_id="DAA08856.1" /db_xref="SGD:S000003830" /translation="MSNNEIVFVTGNANKLKEVQSILTQEVDNNNKTIHLINEALDLE ELQDTDLNAIALAKGKQAVAALGKGKPVFVEDTALRFDEFNGLPGAYIKWFLKSMGLE KIVKMLEPFENKNAEAVTTICFADSRGEYHFFQGITRGKIVPSRGPTTFGWDSIFEPF DSHGLTYAEMSKDAKNAISHRGKAFAQFKEYLYQNDF" gene complement(569621..570598) /gene="LIA1" /locus_tag="YJR070C" /gene_synonym="MMD1" mRNA complement(569621..570598) /gene="LIA1" /locus_tag="YJR070C" /gene_synonym="MMD1" /product="deoxyhypusine monooxygenase" CDS complement(569621..570598) /gene="LIA1" /locus_tag="YJR070C" /gene_synonym="MMD1" /EC_number="1.14.99.29" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008612 peptidyl-lysine modification to peptidyl-hypusine [PMID:16371467]" /experiment="EXISTENCE:direct assay:GO:0019135 deoxyhypusine monooxygenase activity [PMID:16371467]" /experiment="EXISTENCE:mutant phenotype:GO:0000226 microtubule cytoskeleton organization [PMID:14767070]" /experiment="EXISTENCE:mutant phenotype:GO:0008612 peptidyl-lysine modification to peptidyl-hypusine [PMID:16371467]" /experiment="EXISTENCE:mutant phenotype:GO:0019135 deoxyhypusine monooxygenase activity [PMID:16371467]" /note="Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="deoxyhypusine monooxygenase" /protein_id="DAA08857.1" /db_xref="SGD:S000003831" /translation="MSTNFEKHFQENVDECTLEQLRDILVNKSGKTVLANRFRALFNL KTVAEEFATKPEEAKKAIEYIAESFVNDKSELLKHEVAYVLGQTKNLDAAPTLRHVML DQNQEPMVRHEAAEALGALGDKDSLDDLNKAAKEDPHVAVRETCELAINRINWTHGGA KDKENLQQSLYSSIDPAPPLPLEKDATIPELQALLNDPKQPLFQRYRAMFRLRDIGTD EAILALATGFSAESSLFKHEIAYVFGQIGSPAAVPSLIEVLGRKEEAPMVRHEAAEAL GAIASPEVVDVLKSYLNDEVDVVRESCIVALDMYDYENSNELEYAPTAN" gene complement(570967..572124) /gene="NPA3" /locus_tag="YJR072C" /gene_synonym="EPA1" /gene_synonym="GPN1" mRNA complement(570967..572124) /gene="NPA3" /locus_tag="YJR072C" /gene_synonym="EPA1" /gene_synonym="GPN1" /product="GTPase NPA3" CDS complement(570967..572124) /gene="NPA3" /locus_tag="YJR072C" /gene_synonym="EPA1" /gene_synonym="GPN1" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:21844196]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006913 nucleocytoplasmic transport [PMID:21844196]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:15082539]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:21844196]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:21532343]" /note="Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="GTPase NPA3" /protein_id="DAA08858.1" /db_xref="SGD:S000003833" /translation="MSLSTIICIGMAGSGKTTFMQRLNSHLRAEKTPPYVINLDPAVL RVPYGANIDIRDSIKYKKVMENYQLGPNGAIVTSLNLFSTKIDQVIRLVEQKKDKFQN CIIDTPGQIECFVWSASGAIITESFASSFPTVIAYIVDTPRNSSPTTFMSNMLYACSI LYKTKLPMIVVFNKTDVCKADFAKEWMTDFESFQAAIKEDQDLNGDNGLGSGYMSSLV NSMSLMLEEFYSQLDVVGVSSFTGDGFDEFMQCVDKKVDEYDQYYKQEREKALNLKKK KEEMRKQKSLNGLMKDLGLNEKSSAAASDNDSIDAISDLEEDANDGLVDRDEDEGVER EYTFPGEERTKGEVNENSAPDLQRRYQEAMQQVGKTASSETAENIAKYIRN" gene complement(572315..572935) /gene="OPI3" /locus_tag="YJR073C" /gene_synonym="PEM2" mRNA complement(572315..572935) /gene="OPI3" /locus_tag="YJR073C" /gene_synonym="PEM2" /product="bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase" CDS complement(572315..572935) /gene="OPI3" /locus_tag="YJR073C" /gene_synonym="PEM2" /EC_number="2.1.1.17" /EC_number="2.1.1.71" /experiment="EXISTENCE:direct assay:GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity [PMID:2445736]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006656 phosphatidylcholine biosynthetic process [PMID:2445736]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity [PMID:2445736]" /experiment="EXISTENCE:genetic interaction:GO:0006656 phosphatidylcholine biosynthetic process [PMID:2445736]" /experiment="EXISTENCE:mutant phenotype:GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity [PMID:2684666]" /experiment="EXISTENCE:mutant phenotype:GO:0006656 phosphatidylcholine biosynthetic process [PMID:23000174|PMID:6337128]" /note="Methylene-fatty-acyl-phospholipid synthase; catalyzes the last two steps in phosphatidylcholine biosynthesis; also known as phospholipid methyltransferase" /codon_start=1 /product="bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase" /protein_id="DAA08859.1" /db_xref="SGD:S000003834" /translation="MKESVQEIIQQLIHSVDLQSSKFQLAIVCTMFNPIFWNIVARME YHKHSLTKMCGGARKGCYMLAATIFSLGIVRDMVYESALREQPTCSLITGENWTKLGV ALFGLGQVLVLSSMYKLGITGTYLGDYFGILMDERVTGFPFNVSNNPMYQGSTLSFLG IALYKGKPAGLVVSAVVYFMYKIALRWEEPFTAMIYANRDKAKKNM" gene 573095..573751 /gene="MOG1" /locus_tag="YJR074W" mRNA 573095..573751 /gene="MOG1" /locus_tag="YJR074W" /product="Ran GTPase-binding protein MOG1" CDS 573095..573751 /gene="MOG1" /locus_tag="YJR074W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9860978]" /experiment="EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:9860978|PMID:11509570]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:9860978|PMID:11024003]" /note="Conserved nuclear protein that interacts with GTP-Gsp1p; stimulates nucleotide release from Gsp1p; involved in nuclear protein import; nucleotide release is inhibited by Yrb1p" /codon_start=1 /product="Ran GTPase-binding protein MOG1" /protein_id="DAA08860.1" /db_xref="SGD:S000003835" /translation="MKIEKASHISQPVQLSTCTLIDTYPGHQGSMNNKEVELYGGAIT TVVPPGFIDASTLREVPDTQEVYVNSRRDEEEFEDGLATNESIIVDLLETVDKSDLKE AWQFHVEDLTELNGTTKWEALQEDTVQQGTKFTGLVMEVANKWGKPDLAQTVVIGVAL IRLTQFDTDVVISINVPLTKEEASQASNKELPARCHAVYQLLQEMVRKFHVVDTSLFA " gene 573981..575171 /gene="HOC1" /locus_tag="YJR075W" mRNA 573981..575171 /gene="HOC1" /locus_tag="YJR075W" /product="alpha-1,6-mannosyltransferase" CDS 573981..575171 /gene="HOC1" /locus_tag="YJR075W" /experiment="EXISTENCE:direct assay:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:10037752]" /experiment="EXISTENCE:direct assay:GO:0000136 mannan polymerase complex [PMID:10037752]" /experiment="EXISTENCE:physical interaction:GO:0000136 mannan polymerase complex [PMID:9430634]" /note="Alpha-1,6-mannosyltransferase; involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele" /codon_start=1 /product="alpha-1,6-mannosyltransferase" /protein_id="DAA08861.1" /db_xref="SGD:S000003836" /translation="MAKTTKRASSFRRLMIFAIIALISLAFGVRYLFHNSNATDLQKI LQNLPKEISQSINSANNIQSSDSDLVQHFESLAQEIRHQQEVQAKQFDKQRKILEKKI QDLKQTPPEATLRERIAMTFPYDSHVKFPAFIWQTWSNDEGPERVQDIKGMWESKNPG FAHEVLNHDVINALVHHYFYSIPEILETYEALPSIILKIDFFKYLILLVHGGVYADID TFPVQPIPNWIPEELSPSDIGLIVGVEEDAQRADWRTKYIRRLQFGTWIIQAKPGHPV LREIISRIIETTLQRKRDDQLNVNLRNDLNIMSWTGSGLWTDTIFTYFNDFMRSGVRE KVTWKLFHNLNQPKLLSDVLVFPKFSFNCPNQIDNDDPHKKFYFITHLASQFWKNTPK VEQK" gene complement(575354..576601) /gene="CDC11" /locus_tag="YJR076C" /gene_synonym="PSL9" mRNA complement(575354..576601) /gene="CDC11" /locus_tag="YJR076C" /gene_synonym="PSL9" /product="septin CDC11" CDS complement(575354..576601) /gene="CDC11" /locus_tag="YJR076C" /gene_synonym="PSL9" /experiment="EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:1934633]" /experiment="EXISTENCE:direct assay:GO:0001400 mating projection base [PMID:8791410]" /experiment="EXISTENCE:direct assay:GO:0001934 positive regulation of protein phosphorylation [PMID:14527412]" /experiment="EXISTENCE:direct assay:GO:0005200 structural constituent of cytoskeleton [PMID:22144691|PMID:18550837|PMID:29321251]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:12665577]" /experiment="EXISTENCE:direct assay:GO:0005619 ascospore wall [PMID:8636217]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:18826657|PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:18826657]" /experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:18826657]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0010314 phosphatidylinositol-5-phosphate binding [PMID:12665577]" /experiment="EXISTENCE:direct assay:GO:0031105 septin complex [PMID:18550837]" /experiment="EXISTENCE:direct assay:GO:0032160 septin filament array [PMID:15282341]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:12665577]" /experiment="EXISTENCE:direct assay:GO:0072687 meiotic spindle [PMID:18826657]" /experiment="EXISTENCE:genetic interaction:GO:0097271 protein localization to bud neck [PMID:25971666]" /experiment="EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:4950437]" /experiment="EXISTENCE:mutant phenotype:GO:0010314 phosphatidylinositol-5-phosphate binding [PMID:12665577]" /experiment="EXISTENCE:mutant phenotype:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:12665577]" /experiment="EXISTENCE:physical interaction:GO:0031105 septin complex [PMID:9813094]" /note="Component of the septin ring that is required for cytokinesis; present at the ends of rod-like septin hetero-oligomers; C-terminal extension is important for recruitment of Bni5p to the mother-bud neck, which in turn is required for Myo1p recruitment and cytokinesis; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells" /codon_start=1 /product="septin CDC11" /protein_id="DAA08862.1" /db_xref="SGD:S000003837" /translation="MSGIIDASSALRKRKHLKRGITFTVMIVGQSGSGRSTFINTLCG QQVVDTSTTILLPTDTSTEIDLQLREETVELEDDEGVKIQLNIIDTPGFGDSLDNSPS FEIISDYIRHQYDEILLEESRVRRNPRFKDGRVHCCLYLINPTGHGLKEIDVEFIRQL GSLVNIIPVISKSDSLTRDELKLNKKLIMEDIDRWNLPIYNFPFDEDEISDEDYETNM YLRTLLPFAIIGSNEVYEMGGDVGTIRGRKYPWGILDVEDSSISDFVILRNALLISHL HDLKNYTHEILYERYRTEALSGESVAAESIRPNLTKLNGSSSSSTTTRRNTNPFKQSN NINNDVLNPASDMHGQSTGENNETYMTREEQIRLEEERLKAFEERVQQELLLKRQELL QREKELREIEARLEKEAKIKQEE" gene complement(577255..578190) /gene="MIR1" /locus_tag="YJR077C" mRNA complement(577255..578190) /gene="MIR1" /locus_tag="YJR077C" /product="Mir1p" CDS complement(577255..578190) /gene="MIR1" /locus_tag="YJR077C" /experiment="EXISTENCE:direct assay:GO:0005315 phosphate transmembrane transporter activity [PMID:9099701]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:11914276|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:8245029]" /experiment="EXISTENCE:direct assay:GO:0035435 phosphate ion transmembrane transport [PMID:9099701]" /experiment="EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]" /note="Mitochondrial phosphate carrier; imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated" /codon_start=1 /product="Mir1p" /protein_id="DAA08863.1" /db_xref="SGD:S000003838" /translation="MSVSAAPAIPQYSVSDYMKFALAGAIGCGSTHSSMVPIDVVKTR IQLEPTVYNKGMVGSFKQIIAGEGAGALLTGFGPTLLGYSIQGAFKFGGYEVFKKFFI DNLGYDTASRYKNSVYMGSAAMAEFLADIALCPLEATRIRLVSQPQFANGLVGGFSRI LKEEGIGSFYSGFTPILFKQIPYNIAKFLVFERASEFYYGFAGPKEKLSSTSTTLLNL LSGLTAGLAAAIVSQPADTLLSKVNKTKKAPGQSTVGLLAQLAKQLGFFGSFAGLPTR LVMVGTLTSLQFGIYGSLKSTLGCPPTIEIGGGGH" gene 578860..580221 /gene="BNA2" /locus_tag="YJR078W" mRNA 578860..580221 /gene="BNA2" /locus_tag="YJR078W" /product="dioxygenase BNA2" CDS 578860..580221 /gene="BNA2" /locus_tag="YJR078W" /EC_number="1.13.11.52" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0033754 indoleamine 2,3-dioxygenase activity [PMID:21170645]" /experiment="EXISTENCE:genetic interaction:GO:0034354 'de novo' NAD biosynthetic process from tryptophan [PMID:12062417]" /note="Tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase; required for de novo biosynthesis of NAD+ from tryptophan via kynurenine; up-regulated by telomere uncapping, and interacts genetically with capping gene CDC13; overexpression reduces lipid droplet accumulation by skewing glycolytic flux towards biosynthesis of shikimate, aromatic amino acids, and NAD+ during aging and extends lifespan; regulated by Hst1p and Aftp" /codon_start=1 /product="dioxygenase BNA2" /protein_id="DAA08864.1" /db_xref="SGD:S000003839" /translation="MNNTSITGPQVLHRTKMRPLPVLEKYCISPHHGFLDDRLPLTRL SSKKYMKWEEIVADLPSLLQEDNKVRSVIDGLDVLDLDETILGDVRELRRAYSILGFM AHAYIWASGTPRDVLPECIARPLLETAHILGVPPLATYSSLVLWNFKVTDECKKTETG CLDLENITTINTFTGTVDESWFYLVSVRFEKIGSACLNHGLQILRAIRSGDKGDANVI DGLEGLAATIERLSKALMEMELKCEPNVFYFKIRPFLAGWTNMSHMGLPQGVRYGAEG QYRIFSGGSNAQSSLIQTLDILLGVKHTANAAHSSQGDSKINYLDEMKKYMPREHREF LYHLESVCNIREYVSRNASNRALQEAYGRCISMLKIFRDNHIQIVTKYIILPSNSKQH GSNKPNVLSPIEPNTKASGCLGHKVASSKTIGTGGTRLMPFLKQCRDETVATADIKNE DKN" gene 580205..581239 /locus_tag="YJR079W" mRNA join(580205..580347,581053..581239) /locus_tag="YJR079W" /product="hypothetical protein" CDS join(580205..580347,581053..581239) /locus_tag="YJR079W" /note="hypothetical protein; mutation results in impaired mitochondrial respiration" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08865.1" /db_xref="SGD:S000003840" /translation="MKIKIDIIHFINAPPFFFFFVDAEASQLKAFQLFLLGHIFYTYI HTYICDFDEFETKDLAEGKIGDLISRLEFCSNAIIESLPNTFQSFVPVKFSTDKLLEE SKGLLDV" gene complement(580432..581616) /gene="AIM24" /locus_tag="YJR080C" /gene_synonym="FMP26" mRNA complement(580432..581616) /gene="AIM24" /locus_tag="YJR080C" /gene_synonym="FMP26" /product="Aim24p" CDS complement(580432..581616) /gene="AIM24" /locus_tag="YJR080C" /gene_synonym="FMP26" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:24714493]" /experiment="EXISTENCE:mutant phenotype:GO:0007007 inner mitochondrial membrane organization [PMID:24714493]" /note="Protein with a role in determining mitochondrial architecture; inner membrane protein that interacts physically and genetically with the MICOS complex and is required for its integrity" /codon_start=1 /product="Aim24p" /protein_id="DAA08866.1" /db_xref="SGD:S000003841" /translation="MISPRVNTRVWQRSISLLSPQAAKTESNVVTKERTYIENLSKDI ATSRFRLVDENGKIASITVQPDIPICIKKDCLVSIHNLNHLSLSYKWLNFWSNLIKFR SFKSSLFHRIIGSSVLEILAAPNFQTSRRPFDSSRSLSVLNLTGTKDWNVFGKDSIIA FEQNSSLEIKSPIFPSARSLVSNSSKSQLPRKFQILNGRGNVLVCGGGLVYSIELIDE SDKILVNSRNILAINGQSQLDIANSVERQELHVEGAYVGDSSNDTVAPKFIKNQTLKS AYGHTVQFFKRMRSWIRNQYEKRYIYGVDSYFMKIKGPRTILIQTHEMTTSKDNILTK LTSKGHVKKSNVNDNGVNLEKQVANDVNSKIIELANRPSLFIATVSQDGRVDFQSTSK FT" gene complement(581914..582255) /gene="EAF6" /locus_tag="YJR082C" mRNA complement(581914..582255) /gene="EAF6" /locus_tag="YJR082C" /product="Eaf6p" CDS complement(581914..582255) /gene="EAF6" /locus_tag="YJR082C" /experiment="EXISTENCE:curator inference:GO:0004402 histone acetyltransferase activity [PMID:17157260]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]" /experiment="EXISTENCE:direct assay:GO:0033100 NuA3 histone acetyltransferase complex [PMID:17157260]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15485911]" /experiment="EXISTENCE:direct assay:GO:1990467 NuA3a histone acetyltransferase complex [PMID:25104842]" /experiment="EXISTENCE:direct assay:GO:1990468 NuA3b histone acetyltransferase complex [PMID:25104842]" /note="Subunit of the NuA4 acetyltransferase complex; this complex acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3" /codon_start=1 /product="Eaf6p" /protein_id="DAA08867.1" /db_xref="SGD:S000003842" /translation="MTDELKSYEALKAELKKSLQDRREQEDTFDNLQQEIYDKETEYF SHNSNNNHSGHGGAHGSKSHYSGNIIKGFDTFSKSHHSHADSAFNNNDRIFSLSSATY VKQQHGQSQND" gene complement(582608..583537) /gene="ACF4" /locus_tag="YJR083C" mRNA complement(582608..583537) /gene="ACF4" /locus_tag="YJR083C" /product="Acf4p" CDS complement(582608..583537) /gene="ACF4" /locus_tag="YJR083C" /note="hypothetical protein; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate" /codon_start=1 /product="Acf4p" /protein_id="DAA08868.1" /db_xref="SGD:S000003843" /translation="MSEDQRVISQPIELHKLSIVDKHSQGQQQQPHQKQHEVQPESKS PRVTTPLKPKRLAIPISSPQRSTTNQSPVSDHASPISTDQDLIYKLAAKHREINELSF KLEVAQKELKQLELQFKDTLPRNGQQKLGNQNPSEYLSTFTKRIQQTFVDVNNSPNML KGKKSINDFFSKPNNNVNSNINNTLPNRKPNPPPNRSQRMQNIAPSRSSESTPTSGPP LLPPRNTMKNANTTATAGENTPFLQRILNKFNQMNMEEDEFDDLLEKRKSKKDHYYIK ENLGYEYDEVRSEDEDDEEFEPMGDIPVHLFKR" gene 583733..585004 /locus_tag="YJR084W" /gene_synonym="CSN12" mRNA 583733..585004 /locus_tag="YJR084W" /gene_synonym="CSN12" /product="hypothetical protein" CDS 583733..585004 /locus_tag="YJR084W" /gene_synonym="CSN12" /experiment="EXISTENCE:direct assay:GO:0000791 euchromatin [PMID:21149575]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:19061648]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:12446563]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:12446563]" /note="Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08869.1" /db_xref="SGD:S000003844" /translation="MDVDIGCYFEEKRYDDKLLDFIRYDVKTPKKTKYILQRPTATDE ESVRLQRFYQLGVDLKLKYSKRRSLKKQGRIKNATEELLRLANEQLKLFNRIVERETN WIIYPLWVMAKQLIRLANESSELNKDSIEECGRTIHRSFTICLNDRNPRLNENKKIGC YMFANLEFSIYHRLSNKDMIKNLVKVLESRVNARDIPPLNKSLAMEHKSQVVLYNYYL GQYYGCLENDHERGFFHLNEALLQCPMLYVESTGKFVLQGQMEKIMILLVPLALLTKR LYPHWDHPVIAGVITRSKRLSQVYPTLVRSVISGNLSLYEATAASHERFFLSQGLHVV ITLLREVVFTRLVQRCWQWGNDRKSIMPLKILLATKQHDSSANEDEEEQLDALECRLA SAIASGLLRAYLSHSNRCIVFSKKEPFPHSK" gene complement(585120..585437) /gene="TMH11" /locus_tag="YJR085C" mRNA complement(585120..585437) /gene="TMH11" /locus_tag="YJR085C" /product="Tmh11p" CDS complement(585120..585437) /gene="TMH11" /locus_tag="YJR085C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /note="Mitochondrial hypothetical protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="Tmh11p" /protein_id="DAA08870.1" /db_xref="SGD:S000003845" /translation="MEHPAYTLSLLTTAGGLMGYYRKGSIPSLVSGLVFGSVYGIAGY LLHMNRDGGLEMALGASTLLLGAGVIRGMPSRFTKPVPVVLTALGGLGSYYYYNKYKE FYP" gene 586068..586400 /gene="STE18" /locus_tag="YJR086W" mRNA 586068..586400 /gene="STE18" /locus_tag="YJR086W" /product="Ste18p" CDS 586068..586400 /gene="STE18" /locus_tag="YJR086W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8995254]" /experiment="EXISTENCE:direct assay:GO:0005834 heterotrimeric G-protein complex [PMID:8995254]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8995254]" /experiment="EXISTENCE:direct assay:GO:0031680 G-protein beta/gamma-subunit complex [PMID:8417317|PMID:8995254]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0120171 Cdc24p-Far1p-Gbetagamma complex [PMID:10087263]" /experiment="EXISTENCE:genetic interaction:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:2107073]" /experiment="EXISTENCE:genetic interaction:GO:0031680 G-protein beta/gamma-subunit complex [PMID:8417317]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:3151178]" /experiment="EXISTENCE:mutant phenotype:GO:0005834 heterotrimeric G-protein complex [PMID:2105453]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:8649369]" /experiment="EXISTENCE:physical interaction:GO:0031680 G-protein beta/gamma-subunit complex [PMID:8649369]" /experiment="EXISTENCE:physical interaction:GO:0031681 G-protein beta-subunit binding [PMID:8649369|PMID:8417317]" /note="G protein gamma subunit; forms dimer with Ste4p to activate mating signaling pathway, heterotrimer with Gpa1p, Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling; N-terminal phosphorylation of Ste18p functions synergistically with Fus3p docking site on Ste5p to restrict Ste5p plasma membrane recruitment and signaling; combinatorial phosphorylation at S3 and S7, by pheromone and pH stress, modulates Ste18p structure, Fus3p activation" /codon_start=1 /product="Ste18p" /protein_id="DAA08871.1" /db_xref="SGD:S000003846" /translation="MTSVQNSPRLQQPQEQQQQQQQLSLKIKQLKLKRINELNNKLRK ELSRERITASNACLTIINYTSNTKDYTLPELWGYPVAGSNHFIEGLKNAQKNSQMSNS NSVCCTLM" gene complement(586495..587373) /gene="EMC2" /locus_tag="YJR088C" mRNA complement(586495..587373) /gene="EMC2" /locus_tag="YJR088C" /product="Emc2p" CDS complement(586495..587373) /gene="EMC2" /locus_tag="YJR088C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0072546 EMC complex [PMID:19325107]" /experiment="EXISTENCE:genetic interaction:GO:0034975 protein folding in endoplasmic reticulum [PMID:19325107]" /note="Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35" /codon_start=1 /product="Emc2p" /protein_id="DAA08872.1" /db_xref="SGD:S000003848" /translation="MLKDLVREKLLTIMNTKAYTQFNPEQLLQLENEMKIYMKSGDSA LTEGNYFFLMEMLFYVLVYRNQDVDAQVVYNTLRDRLGENSYKMVIMKATLLQINGND KGAIEYLENLLNDDLEYETDFVTYVSIAKKLIAIKTTSKNLSQESVLKEVVALTDKFP LDAELWWYASEIYFEMGQFEKACYCLEQVLCITPFNYACFGRLSETLYYEALRSKKQT KTELLEKALKNALRSVELSELYLKGWALVNIISRELGRNKQNDLIKLSASKLKEISAK SNNKDKITAELILNKI" gene 587718..590582 /gene="BIR1" /locus_tag="YJR089W" mRNA 587718..590582 /gene="BIR1" /locus_tag="YJR089W" /product="survivin" CDS 587718..590582 /gene="BIR1" /locus_tag="YJR089W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16608876]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16608876]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005819 spindle [PMID:16381814]" /experiment="EXISTENCE:direct assay:GO:0005874 microtubule [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0032133 chromosome passenger complex [PMID:19158380]" /experiment="EXISTENCE:direct assay:GO:0051233 spindle midzone [PMID:16381814]" /experiment="EXISTENCE:genetic interaction:GO:0000776 kinetochore [PMID:10557299]" /experiment="EXISTENCE:mutant phenotype:GO:0000022 mitotic spindle elongation [PMID:16381814]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:16608876]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:10557299]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:22908045]" /experiment="EXISTENCE:mutant phenotype:GO:0031134 sister chromatid biorientation [PMID:19528231]" /note="Subunit of chromosomal passenger complex (CPC); CPC is comprised of Ipl1p-Sli15p-Bir1p-Nbl1p and regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension; relative distribution to shortened microtubules increases upon DNA replication stress; sumoylated in an Mms21p-dependent manner; human survivin homolog" /codon_start=1 /product="survivin" /protein_id="DAA08873.1" /db_xref="SGD:S000003849" /translation="MDGQIDKMEKRYSMTKLENRLRTFQDGVALEKKKLKWSFKVIPY QAMAKLGFYFDPVIDPKTSKLKKDSVRCCYCHRQTYNVRDCRSKRKDVLETLSNIMRQ HLTVTDNKQVCLLIYLRNKLLTDYSFHMGVSDWKNDKYFSNPDDENVINLRKFTFQDN WPHSGSQNEHPLGIEKMVNAGLMRYDSSIEGLGDPSMDKTLMNDTCYCIYCKQLLQGW SINDDPMSRHYKVSQNGNCYFFQTRNRFERIKNDNDSITKNCEVSPTLGENGKREVIN TKTASQRQCPLFESPPSSTGPQLDDYNEKTDISVIQHNISVLDGAQGENVKRNSVEEK EQINMENGSTTLEEGNINRDVLADKKEVISTPTAKEIKRPNVQLTQSSSPIKKKRKFK RISPRKIFDEEDSEHSLNNNSANGDNKDKDLVIDFTSHIIKNRDVGRKNAILDDSTDE FSFSNQGHNTFDIPIPTSSHLLKGIDSDNDNVIREDDTGINTDTKGASSKHEKFSVNS EEDLNFSEVKLTGRDSSTNILIRTQIVDQNLGDIDRDKVPNGGSPEVPKTHELIRDNS EKREAQNGEFRHQKDSTVRQSPDILHSNKSGDNSSNITAIPKEEQRRGNSKTSSIPAD IHPKPRKNLQEPRSLSISGKVVPTERKLDNINIDLNFSASDFSPSSQSEQSSKSSSVI STPVASPKINLTRSLHAVKELSGLKKETDDGKYFTNKQETIKILEDVSVKNETPNNEM LLFETGTPIASQENKSRKLFDEEFSGKELDIPIDSSTVEIKKVIKPEFEPVPSVARNL VSGTSSYPRNSRLEEQRKETSTSLADNSKKGSSFNEGNNEKEPNAAEWFKIDENRHLV KNYFHDLLKYINNNDATLANDKDGDLAFLIKQMPAEELDMTFNNWVNLKVQSIKREFI DDCDKKLDILRRDYYTATNFIETLEDDNQLIDIAKKMGIL" gene complement(590872..594327) /gene="GRR1" /locus_tag="YJR090C" /gene_synonym="CAT80" /gene_synonym="COT2" /gene_synonym="RMR3" /gene_synonym="SDC1" /gene_synonym="SSU2" mRNA complement(590872..594327) /gene="GRR1" /locus_tag="YJR090C" /gene_synonym="CAT80" /gene_synonym="COT2" /gene_synonym="RMR3" /gene_synonym="SDC1" /gene_synonym="SSU2" /product="SCF ubiquitin ligase complex subunit GRR1" CDS complement(590872..594327) /gene="GRR1" /locus_tag="YJR090C" /gene_synonym="CAT80" /gene_synonym="COT2" /gene_synonym="RMR3" /gene_synonym="SDC1" /gene_synonym="SSU2" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:15775961|PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:10213692]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:9819356|PMID:9346238|PMID:11259599]" /experiment="EXISTENCE:genetic interaction:GO:0000209 protein polyubiquitination [PMID:9499404]" /experiment="EXISTENCE:mutant phenotype:GO:0000209 protein polyubiquitination [PMID:16093347]" /experiment="EXISTENCE:mutant phenotype:GO:0000751 mitotic cell cycle G1 arrest in response to pheromone [PMID:15942932]" /experiment="EXISTENCE:mutant phenotype:GO:0019005 SCF ubiquitin ligase complex [PMID:9736614]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:9819356]" /experiment="EXISTENCE:mutant phenotype:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:29212878]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:29212878]" /experiment="EXISTENCE:mutant phenotype:GO:0071406 cellular response to methylmercury [PMID:17141224]" /experiment="EXISTENCE:physical interaction:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:10213692]" /note="F-box protein component of an SCF ubiquitin-ligase complex; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCF(Grr1) complex; SCF(Grr1) acts as a ubiquitin-protein ligase directing ubiquitination of substrates such as: Gic2p, Mks1p, Mth1p, Cln1p, Cln2p and Cln3p; involved in carbon catabolite repression, glucose-dependent divalent cation transport, glucose transport, morphogenesis, and sulfite detoxification" /codon_start=1 /product="SCF ubiquitin ligase complex subunit GRR1" /protein_id="DAA08874.1" /db_xref="SGD:S000003850" /translation="MDQDNNNHNDSNRLHPPDIHPNLGPQLWLNSSGDFDDNNNNNNN NNNNNSTRPQMPSRTRETATSERNASEVRDATLNNIFRFDSIQRETLLPTNNGQPLNQ NFSLTFQPQQQTNALNGIDINTVNTNLMNGVNVQIDQLNRLLPNLPEEERKQIHEFKL IVGKKIQEFLVVIEKRRKKILNEIELDNLKLKELRIDNSPQAISYLHKLQRMRLRALE TENMEIRNLRLKILTIIEEYKKSLYAYCHSKLRGQQVENPTDNFIIWINSIDTTESSD LKEGLQDLSRYSRQFINNVLSNPSNQNICTSVTRRSPVFALNMLPSEILHLILDKLNQ KYDIVKFLTVSKLWAEIIVKILYYRPHINKKSQLDLFLRTMKLTSEETVFNYRLMIKR LNFSFVGDYMHDTELNYFVGCKNLERLTLVFCKHITSVPISAVLRGCKFLQSVDITGI RDVSDDVFDTLATYCPRVQGFYVPQARNVTFDSLRNFIVHSPMLKRIKITANNNMNDE LVELLANKCPLLVEVDITLSPNVTDSSLLKLLTRLVQLREFRITHNTNITDNLFQELS KVVDDMPSLRLIDLSGCENITDKTIESIVNLAPKLRNVFLGKCSRITDASLFQLSKLG KNLQTVHFGHCFNITDNGVRALFHSCTRIQYVDFACCTNLTNRTLYELADLPKLKRIG LVKCTQMTDEGLLNMVSLRGRNDTLERVHLSYCSNLTIYPIYELLMSCPRLSHLSLTA VPSFLRPDITMYCRPAPSDFSENQRQIFCVFSGKGVHKLRHYLVNLTSPAFGPHVDVN DVLTKYIRSKNLIFNGETLEDALRRIITDLNQDSAAIIAATGLNQINGLNNDFLFQNI NFERIDEVFSWYLNTFDGIRMSSEEVNSLLLQVNKTFCEDPFSDVDDDQDYVVAPGVN REINSEMCHIVRKFHELNDHIDDFEVNVASLVRVQFQFTGFLLHEMTQTYMQMIELNR QICLVQKTVQESGNIDYQKGLLIWRLLFIDKFIMVVQKYKLSTVVLRLYLKDNITLLT RQRELLIAHQRSAWNNNNDNDANRNANNIVNIVSDAGANDTSNNETNNGNDDNETENP NFWRQFGNRMQISPDQMRNLQMGLRNQNMVRNNNNNTIDESMPDTAIDSQMDEASGTP DEDML" gene complement(595061..598336) /gene="JSN1" /locus_tag="YJR091C" /gene_synonym="PUF1" mRNA complement(595061..598336) /gene="JSN1" /locus_tag="YJR091C" /gene_synonym="PUF1" /product="Jsn1p" CDS complement(595061..598336) /gene="JSN1" /locus_tag="YJR091C" /gene_synonym="PUF1" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21685478|PMID:15024427|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0032473 cytoplasmic side of mitochondrial outer membrane [PMID:16107558]" /experiment="EXISTENCE:genetic interaction:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:11101532]" /experiment="EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:16107558]" /experiment="EXISTENCE:mutant phenotype:GO:0051654 establishment of mitochondrion localization [PMID:16107558]" /note="Member of the Puf family of RNA-binding proteins; interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl; JSN1 has a paralog, PUF2, that arose from the whole genome duplication" /codon_start=1 /product="Jsn1p" /protein_id="DAA08875.1" /db_xref="SGD:S000003851" /translation="MDKSKQMNINNLSNIPEVIDPGITIPIYEEEYENNGESNSQLQQ QPQKLGSYRSRAGKFSNTLSNLLPSISAKLHHSKKNSHGKNGAEFSSSNNSSQSTVAS KTPRASPSRSKMMESSIDGVTMDRPGSLTPPQDMEKLVHFPDSSNNFLIPAPRGSSDS FNLPHQISRTRNNTMSSQITSISSIAPKPRTSSGIWSSNASANDPMQQHLLQQLQPTT SNNTTNSNTLNDYSTKTAYFDNMVSTSGSQMADNKMNTNNLAIPNSVWSNTRQRSQSN ASSIYTDAPLYEQPARASISSHYTIPTQESPLIADEIDPQSINWVTMDPTVPSINQIS NLLPTNTISISNVFPLQHQQPQLNNAINLTSTSLATLCSKYGEVISARTLRNLNMALV EFSSVESAVKALDSLQGKEVSMIGAPSKISFAKILPMHQQPPQFLLNSQGLPLGLENN NLQPQPLLQEQLFNGAVTFQQQGNVSIPVFNQQSQQSQHQNHSSGSAGFSNVLHGYNN NNSMHGNNNNSANEKEQCPFPLPPPNVNEKEDLLREIIELFEANSDEYQINSLIKKSL NHKGTSDTQNFGPLPEPLSGREFDPPKLRELRKSIDSNAFSDLEIEQLAIAMLDELPE LSSDYLGNTIVQKLFEHSSDIIKDIMLRKTSKYLTSMGVHKNGTWACQKMITMAHTPR QIMQVTQGVKDYCTPLINDQFGNYVIQCVLKFGFPWNQFIFESIIANFWVIVQNRYGA RAVRACLEAHDIVTPEQSIVLSAMIVTYAEYLSTNSNGALLVTWFLDTSVLPNRHSIL APRLTKRIVELCGHRLASLTILKVLNYRGDDNARKIILDSLFGNVNAHDSSPPKELTK LLCETNYGPTFVHKVLAMPLLEDDLRAHIIKQVRKVLTDSTQIQPSRRLLEEVGLASP SSTHNKTKQQQQQHHNSSISHMFATPDTSGQHMRGLSVSSVKSGGSKHTTMNTTTTNG SSASTLSPGQPLNANSNSSMGYFSYPGVFPVSGFSGNASNGYAMNNDDLSSQFDMLNF NNGTRLSLPQLSLTNHNNTTMELVNNVGSSQPHTNNNNNNNNTNYNDDNTVFETLTLH SAN" gene 598735..603078 /gene="BUD4" /locus_tag="YJR092W" mRNA 598735..603078 /gene="BUD4" /locus_tag="YJR092W" /product="Bud4p" CDS 598735..603078 /gene="BUD4" /locus_tag="YJR092W" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:22553209]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:22553209]" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:23345395]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:27385335|PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0005525 GTP binding [PMID:22553209]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:22553209]" /experiment="EXISTENCE:mutant phenotype:GO:0031106 septin ring organization [PMID:23345395]" /experiment="EXISTENCE:mutant phenotype:GO:0097271 protein localization to bud neck [PMID:22553209]" /note="Anillin-like protein involved in bud-site selection; required for the axial budding pattern; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; functions as a platform linking the cytokinesis tag septins to the axial landmark through its multiple domains; in vivo substrate of Cdc28p/Clb2p" /codon_start=1 /product="Bud4p" /protein_id="DAA08876.1" /db_xref="SGD:S000003852" /translation="MHDAESTVDSLLKEIDNEMEQTKSNITQNGSEDTPHNWKLPLQE IGDDTMEMLVKHNTRSNATENSRGRSPSKMSTISNESLNLGLLRVNSELEESPAAVHQ ERIKNSVANGALGHANSPKVLNNLKNMAQDIDKLARDEEKPVKLSSSPLKFTLKSTQP LLSYPESPIHRSSIEIETNYDDEDEEEEDAYTCLTQSPQILHSPSRIPITNAVSINKL NLDFTLNPNESDKSLVSDTSVDSTGRELDTKTIPELPFCMSSTPEMTPVDEKCNLPSK LLNTSNNSHSDSRSPTASVEDLNISTNLPGADSSQNNPVTTDADALIENDVVRDLQQN MEHIDDAFDEKKVLDEGCSNEPVTFLGENDTRSIVYSNKGTNANVQEFSQEDSLAHSE PKFKDLNATSDDVWNEDKETDANISTSTKSEESYIADYKVTRQEDWDTKKLHQESEHA NEQPAIIPQKDSSEETFTELNNESEFQRNFKDGEEYRIVQHEESLYGQRTKSPEENII NGSEIGVDHGEAAEVNEPLAKTSAEEHDLSSSCEDQSVSEARNKDRIEEKEVETKDEN IETEKDESEYHKVEENEEPEHVPLLPPLPRWEEIQFNEPFIDENDTSNDSIDLTRSMK PSDYISIWHIQEEEIKSNSPESIANSQFSQQSSITTASTVDSKKDNGSTSFKFKPRIV SRSRIYNPKSRVSSLNYYDNEDYILSNSEWNALDPMRRNTLISKRIQDNIRTQKGHAP LIRPSIMKLNGEDSGFQNHFLEVEQPQEHENIPLSTHLSEQDITTNVGLDEQKLPTNT QDEAEISIREIESAGDITFNRGDLLSLSFDEELGQDFANFLDALDHDSTSFNHGPDDS SSFQRDSSKKSFNSLWESSYELKPPPSIRKQPIAPDVLQKLLESDTKDDADLEKIREE RITEPRTGLGIGMLKTPVKDVSIALAASIKGYEASFSDTDSRPEGMNNSDAITLNMFD DFEEDKMTPSTPVRSISPIKRHVSSPFKVVKAGNKQENNEINIKAEEEIEPMTQQETD GLKQDIPPLLAQTKDNVEAKEETITQLEEPQDVEQEFPDMGTLYLSIKAISTLALYGT KSHRATYAIVFDNGENVVQTPWESLPYDGNIRINKEFELPIDFKGKAETSSASSERDS YKKCVITLKCKYEKPRHELVEIVDKVPVGKSFFGKTKYKFEKKYVQKKPKQDEWDYLF AQDGSFARCEIEINEEFLKNVAFNTSHMHYNMINKWSRIADKIHGSKRLYELPRKAPH KVASLDVEACFLERTSAFEQFPKQFSLVNKIVSKYKLQQNIYKEGYLLQDGGDLKGKI ENRFFKLHGSQLSGYHEISRKAKIDINLLKVTKVLRNEDIQADNGGQRNFTDWVLFNE CFQLVFDDGERITFNAECSNEEKSDWYNKLQEVVELNVFHQPWVKKYCEKLAEEEKTR TTGHNLKQDFN" gene complement(603220..604203) /gene="FIP1" /locus_tag="YJR093C" mRNA complement(603220..604203) /gene="FIP1" /locus_tag="YJR093C" /product="cleavage polyadenylation factor subunit FIP1" CDS complement(603220..604203) /gene="FIP1" /locus_tag="YJR093C" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]" /experiment="EXISTENCE:direct assay:GO:0006397 mRNA processing [PMID:11344258]" /experiment="EXISTENCE:genetic interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:21282348]" /experiment="EXISTENCE:mutant phenotype:GO:0003723 RNA binding [PMID:11238938]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:21282348]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:7736590]" /note="Subunit of cleavage polyadenylation factor (CPF); interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p" /codon_start=1 /product="cleavage polyadenylation factor subunit FIP1" /protein_id="DAA08877.1" /db_xref="SGD:S000003853" /translation="MSSSEDEDDKFLYGSDSELALPSSKRSRDDEADAGASSNPDIVK RQKFDSPVEETPATARDDRSDEDIYSDSSDDDSDSDLEVIISLGPDPTRLDAKLLDSY STAATSSSKDVISVATDVSNTITKTSDERLITEGEANQGVTATTVKATESDGNVPKAM TGSIDLDKEGIFDSVGITTIDPEVLKEKPWRQPGANLSDYFNYGFNEFTWMEYLHRQE KLQQDYNPRRILMGLLSLQQQGKLNSANDTDSNLGNIIDNNNNVNNANMSNLNSNMGN SMSGTPNPPAPPMHPSFPPLPMFGSFPPFPMPGMMPPMNQQPNQNQNQNSK" gene complement(604569..605651) /gene="IME1" /locus_tag="YJR094C" mRNA complement(604569..605651) /gene="IME1" /locus_tag="YJR094C" /product="transcription factor IME1" CDS complement(604569..605651) /gene="IME1" /locus_tag="YJR094C" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8462841]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:29472539]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:8205723]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:20876298]" /experiment="EXISTENCE:mutant phenotype:GO:0040020 regulation of meiotic nuclear division [PMID:8205723]" /experiment="EXISTENCE:mutant phenotype:GO:0043934 sporulation [PMID:9660952]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9660952]" /experiment="EXISTENCE:physical interaction:GO:0008134 transcription factor binding [PMID:8628320]" /note="Master meiotic regulator active only during meiotic events; activates transcription of early meiotic genes through interaction with Ume6p; regulator of meiotic commitment; phosphorylated by Rim11p; degraded by the 26S proteasome following phosphorylation by Ime2p; transcription is negatively regulated in cis by the IRT1 long noncoding antisense RNA" /codon_start=1 /product="transcription factor IME1" /protein_id="DAA08878.1" /db_xref="SGD:S000003854" /translation="MQADMHGKLHAALEDGFFLFPFEQQQQPNIYYDTTTDQEDRPCF SFGSTISPRSWHFEKSDKIASSQLQNLVHTQPIHLINPQILFNEEFLNLENIDSQPIS KETKTTKDCTMATGPERGKKSSESTRSSSLSSLFSNDESASTFHSSFNNHDNFQKSNR NGDDIDISDTIKYETNTNAQKDIKIFQENFEFNEFPYTQDFYPYTTNYTYSKPTNIHE SINSKNTDSYSQYQDQFPPHTDNIHSFNNRHYSNHKSTNCNYYNNTSNNNNASDNVYE ADPFIDEPQVPSYYYPLEIAFDVEKSPPPSLQKLNSKELEFLKKLNSKLSRYAAAYSF SSSNDQDYYDKVRFQEISYKFSKTYS" gene complement(605936..607424) /gene="IRT1" /locus_tag="YNCJ0028C" ncRNA complement(605936..607424) /ncRNA_class="other" /gene="IRT1" /locus_tag="YNCJ0028C" /product="IRT1" /note="Long noncoding RNA that governs mating-type control of gametogenesis; located in the IME1 promoter; in haploids, expression of IME1, the central inducer of gametogenesis, is inhibited in cis by transcription of IRT1, which recruits the Set2p histone methyltransferase and the Set3p histone deacetylase complex to establish repressive chromatin at the IME1 promoter" /db_xref="SGD:S000178119" gene 608305..608858 /gene="RPL43B" /locus_tag="YJR094W-A" mRNA join(608305..608306,608582..608858) /gene="RPL43B" /locus_tag="YJR094W-A" /product="ribosomal 60S subunit protein L43B" CDS join(608305..608306,608582..608858) /gene="RPL43B" /locus_tag="YJR094W-A" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /codon_start=1 /product="ribosomal 60S subunit protein L43B" /protein_id="DAA08879.1" /db_xref="SGD:S000003855" /translation="MAKRTKKVGITGKYGVRYGSSLRRQVKKLEIQQHARYDCSFCGK KTVKRGAAGIWTCSCCKKTVAGGAYTVSTAAAATVRSTIRRLREMVEA" gene 609773..610741 /gene="SFC1" /locus_tag="YJR095W" /gene_synonym="ACR1" mRNA 609773..610741 /gene="SFC1" /locus_tag="YJR095W" /gene_synonym="ACR1" /product="Sfc1p" CDS 609773..610741 /gene="SFC1" /locus_tag="YJR095W" /gene_synonym="ACR1" /experiment="EXISTENCE:direct assay:GO:0005469 succinate:fumarate antiporter activity [PMID:9395087]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0015741 fumarate transport [PMID:9395087]" /experiment="EXISTENCE:direct assay:GO:0015744 succinate transport [PMID:9395087]" /note="Mitochondrial succinate-fumarate transporter; transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization" /codon_start=1 /product="Sfc1p" /protein_id="DAA08880.1" /db_xref="SGD:S000003856" /translation="MSQKKKASHPAINLMAGGTAGLFEALCCHPLDTIKVRMQIYRRV AGIEHVKPPGFIKTGRTIYQKEGFLALYKGLGAVVIGIIPKMAIRFSSYEFYRTLLVN KESGIVSTGNTFVAGVGAGITEAVLVVNPMEVVKIRLQAQHLTPSEPNAGPKYNNAIH AAYTIVKEEGVSALYRGVSLTAARQATNQGANFTVYSKLKEFLQNYHQMDVLPSWETS CIGLISGAIGPFSNAPLDTIKTRLQKDKSISLEKQSGMKKIITIGAQLLKEEGFRALY KGITPRVMRVAPGQAVTFTVYEYVREHLENLGIFKKNDTPKPKPLK" gene 611195..612043 /locus_tag="YJR096W" mRNA 611195..612043 /locus_tag="YJR096W" /product="aldo-keto reductase superfamily protein" CDS 611195..612043 /locus_tag="YJR096W" /experiment="EXISTENCE:direct assay:GO:0004032 aldose reductase (NADPH) activity [PMID:11306085|PMID:12271459]" /experiment="EXISTENCE:direct assay:GO:0004033 aldo-keto reductase (NADPH) activity [PMID:17140678]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0019568 arabinose catabolic process [PMID:12271459]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:17919749]" /experiment="EXISTENCE:mutant phenotype:GO:0019568 arabinose catabolic process [PMID:12271459]" /experiment="EXISTENCE:mutant phenotype:GO:0042843 D-xylose catabolic process [PMID:12271459]" /note="Xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS" /codon_start=1 /product="aldo-keto reductase superfamily protein" /protein_id="DAA08881.1" /db_xref="SGD:S000003857" /translation="MVPKFYKLSNGFKIPSIALGTYDIPRSQTAEIVYEGVKCGYRHF DTAVLYGNEKEVGDGIIKWLNEDPGNHKREEIFYTTKLWNSQNGYKRAKAAIRQCLNE VSGLQYIDLLLIHSPLEGSKLRLETWRAMQEAVDEGLVKSIGVSNYGKKHIDELLNWP ELKHKPVVNQIEISPWIMRQELADYCKSKGLVVEAFAPLCHGYKMTNPDLLKVCKEVD RNPGQVLIRWSLQHGYLPLPKTKTVKRLEGNLAAYNFELSDEQMKFLDHPDAYEPTDW ECTDAP" gene 612413..612931 /gene="JJJ3" /locus_tag="YJR097W" /gene_synonym="DPH4" mRNA 612413..612931 /gene="JJJ3" /locus_tag="YJR097W" /gene_synonym="DPH4" /product="Jjj3p" CDS 612413..612931 /gene="JJJ3" /locus_tag="YJR097W" /gene_synonym="DPH4" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008198 ferrous iron binding [PMID:22367199]" /experiment="EXISTENCE:mutant phenotype:GO:0017183 protein histidyl modification to diphthamide [PMID:15485916]" /note="Iron-binding protein; involved in targeting cytoplasmic SRP-independent proteins to the ER; contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4" /codon_start=1 /product="Jjj3p" /protein_id="DAA08882.1" /db_xref="SGD:S000003858" /translation="MSLVNSLTHYEILRIPSDATQDEIKKAYRNRLLNTHPDKLSKSI HDTVSNVTINKIQDAYKILSNIKTRREYDRLILENYKRQGFHNCGDGLDEFSLDDFSF DEDKLEFMMNCPRCQFVGGFHFSESLLDECIDNVDAMERSHSGYQLLTQCSACSLWLK VNFDIEEEQEGQ" rep_origin 612846..613278 /note="ARS1019; Autonomously Replicating Sequence" /db_xref="SGD:S000028456" gene complement(613186..615156) /locus_tag="YJR098C" mRNA complement(613186..615156) /locus_tag="YJR098C" /product="hypothetical protein" CDS complement(613186..615156) /locus_tag="YJR098C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08883.2" /db_xref="SGD:S000003859" /translation="MMATPATDLISDNDKYNKQCLSDSSDSGSDVSFFSVNESEGELD TMEKVDTLIGGARVISNKVEKDSDSEQRGRKKETTGPNNYHNLEEKQASAISLDADDE DLDEIISYSHDGNYDSSHKTFSFSLPFGNTNFRSSSPLAIIKTVLPKTPDEFIKKNLR KNEIKQKLKKSTSISSLEEIELFKYERGIDNSRLRAVKESLEMDALKNSIKQITADPF DKTHDGYYRSRLESIWNELEGDVVIMGGYRGSVLRDATTHKRIWIPLKAGLNMTKVDL LIGPNDEDELKTQKEIVPDGMLTHIGPVDISKRLIKRLDANPNLNVQQFGYDWRLSLD ISAKHLTTKLEEIYNKQKNKKGIYIIAHSMGGLVAHKVLQDCTHLIRGIIYVGSPSQC PNILGPIRFGDDVMWNKTIFTKETNFFMRSSFYFLPLDGRCFVDKITLERYDFDFFDT DVWKTLGLSPLVNEKREESAHEKSKLLPRKTKSALSLKATLNATTKFVLNAPVVRNVA GNNKQVPRDVPFDEVFHTSYEDSCEYLARTLKRTKNYLDSLDYDPNKEYPPLAMVYGN KVPTVRGAKVNGIQDIKDGNYEDFYYGPGDGVVHHKWLLPEQRGFPVVCKIASSSGHV SLMTDLKSMAKAFISIVDSEKEGRRSRTRTSS" gene 615576..616286 /gene="YUH1" /locus_tag="YJR099W" mRNA 615576..616286 /gene="YUH1" /locus_tag="YJR099W" /product="ubiquitin-specific protease YUH1" CDS 615576..616286 /gene="YUH1" /locus_tag="YJR099W" /EC_number="3.4.19.12" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:1429680]" /experiment="EXISTENCE:curator inference:GO:0010992 ubiquitin recycling [PMID:1429680]" /experiment="EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:1429680]" /note="Ubiquitin C-terminal hydrolase; cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p" /codon_start=1 /product="ubiquitin-specific protease YUH1" /protein_id="DAA08884.1" /db_xref="SGD:S000003860" /translation="MSGENRAVVPIESNPEVFTNFAHKLGLKNEWAYFDIYSLTEPEL LAFLPRPVKAIVLLFPINEDRKSSTSQQITSSYDVIWFKQSVKNACGLYAILHSLSNN QSLLEPGSDLDNFLKSQSDTSSSKNRFDDVTTDQFVLNVIKENVQTFSTGQSEAPEAT ADTNLHYITYVEENGGIFELDGRNLSGPLYLGKSDPTATDLIEQELVRVRVASYMENA NEEDVLNFAMLGLGPNWE" gene complement(616351..617334) /gene="AIM25" /locus_tag="YJR100C" /gene_synonym="SLM35" mRNA complement(616351..617334) /gene="AIM25" /locus_tag="YJR100C" /gene_synonym="SLM35" /product="Aim25p" CDS complement(616351..617334) /gene="AIM25" /locus_tag="YJR100C" /gene_synonym="SLM35" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:27922823]" /experiment="EXISTENCE:genetic interaction:GO:0034605 cellular response to heat [PMID:27922823]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:27922823]" /experiment="EXISTENCE:mutant phenotype:GO:1903147 negative regulation of autophagy of mitochondrion [PMID:27922823]" /note="Mitochondria hypothetical protein; interacts genetically with TOR1 to regulate chronological lifespan, and the response to both heat shock and oxidative stress; involved in maintaining the integrity of the mitochondrial network; negative regulator of mitophagy flux; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant is viable and displays an elevated frequency of mitochondrial genome loss; similar to murine NOR1" /codon_start=1 /product="Aim25p" /protein_id="DAA08885.1" /db_xref="SGD:S000003861" /translation="MHRTAIFLTYRSCMRNFSTLSKTLTVSSGKVIRNGPFRRVIREK NQITKAPSVKAFKENSNSGIIKVHDPIATTILNEPTVIIERQIEFMNVFLGFEQANRY AIMDVNGNKIASMMERDFSITKAIMRQFYRLHRPFLVDVFDNWGNVIMTIKRPFSFIN SHIKTIIPPSAYVDNGSDSTHYHDGKEGTTVGETIQNWHLWRRRYELFQKDGVEGSTF DQFGKIDAPFLSFDFPVTDADGKIMASVDRNWVGLGREMFTDTGVYVVRFDSQRCFDN IYPTEMLSSQVLTLDQRAVLLANAVSIDFDYFSRHSRQTGGFLSFGGGYDE" gene 617919..618019 /locus_tag="YNCJ0029W" tRNA join(617919..617956,617976..618019) /locus_tag="YNCJ0029W" /product="tRNA-Leu" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]" /experiment="EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]" /note="Leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis" /db_xref="SGD:S000006654" gene 618234..619034 /gene="RSM26" /locus_tag="YJR101W" /gene_synonym="mS42" mRNA 618234..619034 /gene="RSM26" /locus_tag="YJR101W" /gene_synonym="mS42" /product="mitochondrial 37S ribosomal protein RSM26" CDS 618234..619034 /gene="RSM26" /locus_tag="YJR101W" /gene_synonym="mS42" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit" /codon_start=1 /product="mitochondrial 37S ribosomal protein RSM26" /protein_id="DAA08886.1" /db_xref="SGD:S000003862" /translation="MLVFKRGIHVVPKLPNSKALLQNGVPNILSSSGFKTVWFDYQRY LCDKLTLATAGQSLESYYPFHILLKTAGNPLQSNIFNLASSIHNNHLFVENILPSAVE HGTNSNAVVKTEPSRLFLSKIKDSFNGSDWEVVKEEMIYRAENEVLGQGWLFLVENNE KKLFILTSNNNGTPYYFPRNQSFDLNSAISIDEFATLKQMKELIGKSTKLNGKVQDWT MPIICVNLWDHAYLHDYGVGNRSKYVKNVLDNLNWSVVNNRIFSGISK" gene complement(619157..619765) /gene="VPS25" /locus_tag="YJR102C" /gene_synonym="VPL12" /gene_synonym="VPT25" mRNA complement(619157..619765) /gene="VPS25" /locus_tag="YJR102C" /gene_synonym="VPL12" /gene_synonym="VPT25" /product="ESCRT-II subunit protein VPS25" CDS complement(619157..619765) /gene="VPS25" /locus_tag="YJR102C" /gene_synonym="VPL12" /gene_synonym="VPT25" /experiment="EXISTENCE:direct assay:GO:0000814 ESCRT II complex [PMID:12194858]" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:15329733|PMID:15469844]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11278625]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:15469844|PMID:15329733]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12194858]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /note="Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome" /codon_start=1 /product="ESCRT-II subunit protein VPS25" /protein_id="DAA08887.1" /db_xref="SGD:S000003863" /translation="MSALPPVYSFPPLYTRQPNSLTRRQQISTWIDIISQYCKTKKIW YMSVDGTVINDNELDSGSTDNDDSKKISKNLFNNEDIQRSVSQVFIDEIWSQMTKEGK CLPIDQSGRRSSNTTTTRYFILWKSLDSWASLILQWFEDSGKLNQVITLYELSEGDET VNWEFHRMPESLLYYCLKPLCDRNRATMLKDENDKVIAIKVV" gene 620754..622490 /gene="URA8" /locus_tag="YJR103W" mRNA 620754..622490 /gene="URA8" /locus_tag="YJR103W" /product="CTP synthase URA8" CDS 620754..622490 /gene="URA8" /locus_tag="YJR103W" /EC_number="6.3.4.2" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0003883 CTP synthase activity [PMID:7559626]" /experiment="EXISTENCE:direct assay:GO:0006241 CTP biosynthetic process [PMID:7559626]" /experiment="EXISTENCE:direct assay:GO:0097268 cytoophidium [PMID:20713603]" /experiment="EXISTENCE:mutant phenotype:GO:0003883 CTP synthase activity [PMID:8121398]" /note="Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication" /codon_start=1 /product="CTP synthase URA8" /protein_id="DAA08888.2" /db_xref="SGD:S000003864" /translation="MKYVVVSGGVISGIGKGVLASSTGMLLKTLGLKVTSIKIDPYMN IDAGTMSPLEHGECFVLDDGGETDLDLGNYERYLGITLSRDHNITTGKIYSHVISRER RGDYLGKTVQIVPHLTNAIQDWIQRVSKIPVDDTGLEPDVCIIELGGTVGDIESAPFV EALRQFQFEVGRENFALIHVSLVPVIHGEQKTKPTQAAIKDLRSLGLIPDMIACRCSE ELNRSTIDKIAMFCHVGPEQVVNVHDVNSTYHVPLLLLKQHMIDYLHSRLKLGEVPLT LEDKERGSQLLTNWENMTKNLDDSDDVVKIALVGKYTNLKDSYLSVTKSLEHASMKCR RQLEILWVEASNLEPETQEVDKNKFHDSWNKLSSADGILVPGGFGTRGIEGMILAAKW ARESGVPFLGVCLGLQVAAIEFARNVIGRPNSSSTEFLDETLLAPEDQVVIYMPEIDK EHMGGTMRLGLRPTIFQPNSEWSNIRKLYGEVNEVHERHRHRYEINPKIVNDMESRGF IFVGKDETGQRCEIFELKGHPYYVGTQYHPEYTSKVLEPSRPFWGLVAAASGTLGEVI KDINLSEGNENE" gene complement(622550..623014) /gene="SOD1" /locus_tag="YJR104C" /gene_synonym="CRS4" mRNA complement(622550..623014) /gene="SOD1" /locus_tag="YJR104C" /gene_synonym="CRS4" /product="superoxide dismutase SOD1" CDS complement(622550..623014) /gene="SOD1" /locus_tag="YJR104C" /gene_synonym="CRS4" /EC_number="1.15.1.1" /experiment="EXISTENCE:direct assay:GO:0004784 superoxide dismutase activity [PMID:3290902]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18977757|PMID:24647101]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:11500508]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:36630448|PMID:11500508]" /experiment="EXISTENCE:direct assay:GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [PMID:36630448]" /experiment="EXISTENCE:mutant phenotype:GO:0006801 superoxide metabolic process [PMID:3290902]" /experiment="EXISTENCE:mutant phenotype:GO:0006878 intracellular copper ion homeostasis [PMID:8530401]" /experiment="EXISTENCE:mutant phenotype:GO:0006882 intracellular zinc ion homeostasis [PMID:11581253]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:20176017]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:24647101]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:24647101]" /experiment="EXISTENCE:mutant phenotype:GO:0050821 protein stabilization [PMID:23332757]" /experiment="EXISTENCE:mutant phenotype:GO:1901856 negative regulation of cellular respiration [PMID:23332757]" /experiment="EXISTENCE:mutant phenotype:GO:1990748 cellular detoxification [PMID:36630448]" /experiment="EXISTENCE:physical interaction:GO:0050821 protein stabilization [PMID:23332757]" /note="Cytosolic copper-zinc superoxide dismutase; also sulfide oxidase; detoxifies superoxide and hydrogen sulfide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; abundance increases under DNA replication stress; localization to mitochondrial intermembrane space is modulated by MICOS complex; human ortholog SOD1 implicated in ALS complements a null allele" /codon_start=1 /product="superoxide dismutase SOD1" /protein_id="DAA08889.1" /db_xref="SGD:S000003865" /translation="MVQAVAVLKGDAGVSGVVKFEQASESEPTTVSYEIAGNSPNAER GFHIHEFGDATNGCVSAGPHFNPFKKTHGAPTDEVRHVGDMGNVKTDENGVAKGSFKD SLIKLIGPTSVVGRSVVIHAGQDDLGKGDTEESLKTGNAGPRPACGVIGLTN" gene 623581..624603 /gene="ADO1" /locus_tag="YJR105W" mRNA 623581..624603 /gene="ADO1" /locus_tag="YJR105W" /product="adenosine kinase" CDS 623581..624603 /gene="ADO1" /locus_tag="YJR105W" /EC_number="2.7.1.20" /experiment="EXISTENCE:direct assay:GO:0004001 adenosine kinase activity [PMID:11223943]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004001 adenosine kinase activity [PMID:11223943]" /experiment="EXISTENCE:mutant phenotype:GO:0006144 purine nucleobase metabolic process [PMID:11223943]" /note="Adenosine kinase; required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle" /codon_start=1 /product="adenosine kinase" /protein_id="DAA08890.1" /db_xref="SGD:S000003866" /translation="MTAPLVVLGNPLLDFQADVTAEYLAKYSLKENDAILVDAKSGDA KMAIFDELLQMPETKLVAGGAAQNTARGAAYVLGAGQVVYFGSVGKDKFSERLLNENE KAGVKSMYQVQNDIGTGKCAALITGHNRSLVTDLGAANFFTPDHLDKHWDLVEAAKLF YIGGFHLTVSPDAIVKLGQHAKENSKPFVLNFSAPFIPHVFKDALARVLPYATVIIAN ESEAEAFCDAFQLDCANTDLEAIAQRIVKDSPVEKTVIFTHGVEPTVVVSSKGTSTYP VKPLDSSKIVDTNGAGDAFAGGFMAGLTKGEDLETSIDMGQWLAALSIQEVGPSYPSE KISYSK" gene 624838..627015 /gene="ECM27" /locus_tag="YJR106W" mRNA 624838..627015 /gene="ECM27" /locus_tag="YJR106W" /product="Ecm27p" CDS 624838..627015 /gene="ECM27" /locus_tag="YJR106W" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006874 intracellular calcium ion homeostasis [PMID:27242146]" /experiment="EXISTENCE:mutant phenotype:GO:0070316 regulation of G0 to G1 transition [PMID:27242146]" /note="Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p" /codon_start=1 /product="Ecm27p" /protein_id="DAA08891.2" /db_xref="SGD:S000003867" /translation="MDWAINVAHPRLLYKDPKLSVTFIVPSLFHIIIAFVLLGICASD FLCPNVAHISDPNSLRSNGSLVSKTASHASHTGALMAVLLSWCNSSPDLFSNLMSWAT STRETRSTSVSLSIGEVLGACGIILCIVEGSIFIIMSRTHIEISQIQKLSIMRDLLFS LAAMCVMSYVSLMNQVTVLNCLLMAFLYAFYLVVKLTFKLNHSAETPDETAADTSLRE NSVSPFLDDSLMASGLLPPIQPGFDISNSITHGIKPSLLSAMDFNSFLSMLENSSLEE DDSRNEMAELNTLRSMTPGQHWSASATVAGEATSAGRPFSEPTNAFTEYRDSERAINS SPAVFAPYRDNPDDEESQEQVLLETTTHGHFGAQEMRRFSKRSLGWIIKIFIPHLSNF SQKSISDAIFSIITVPFFIIFKLSCPQPPSDILSYDPTLNRYSLTTLPIILLFIQSIT APFLLCSILSVLLTYHLGYLVYLFPLILAMALILLLTAFITKVNLHNKFTLSLDSSNI LQEKLQKRKLLERLNTSIQIIFLAIGIINIIIWISLLANSLIEMMEIYQKILGLSKAI LGLTIFAWGNSVGDLISNISMCRLYKTQTHYQDRVRLATKFFMISCASCLGGVMLNSM GGIGFSGLVSMLFIGAFNDNEWWFLRKVKLQETSQLDNTLNYKFIVSCVFIILQIILL LLFFGGPNNIKRRLTKEMKLVGISMCGLWALATLINILLELFS" gene 627340..628326 /gene="LIH1" /locus_tag="YJR107W" mRNA 627340..628326 /gene="LIH1" /locus_tag="YJR107W" /product="putative lipase" CDS 627340..628326 /gene="LIH1" /locus_tag="YJR107W" /EC_number="3.1.1.3" /note="Putative lipase" /codon_start=1 /product="putative lipase" /protein_id="DAA08892.2" /db_xref="SGD:S000003868" /translation="MPVVHCSSNLPITPYIYERLVYFIKASSISSCISDNLLLVNKTF NDGGCPPHINFCNDEIINPTAGQTVVELVLNAKKGELGSGYLAVDHGKKVVILAFRGS TTRQDWFSDFEIYPVNYSPLCVKEYRKLIEEGKIRECEGCKMHRGFLRFTETLGMDVF KKMESILESFPEYRIVVTGHSLGAALASLAGIELKIRGFDPLVLTFATPKIFNSEMKQ WVDELFETDAIEKESILKDEIQFRKGYFRVVHTGDYIPMVPPFYHPAGLEMFINKVGL PQNAEDIEYRGKNNRLTLKDGFREGMSGLVEDWLHVYEHRAYFIDVVGCSGL" gene complement(628457..628693) /locus_tag="YJR107C-A" mRNA complement(628457..628693) /locus_tag="YJR107C-A" /product="hypothetical protein" CDS complement(628457..628693) /locus_tag="YJR107C-A" /experiment="EXISTENCE:mutant phenotype:GO:0071470 cellular response to osmotic stress [PMID:26554900]" /note="hypothetical protein; encodes new type of domain, which ab initio modeling suggests is predominantly alpha-helical; nonessential for growth, deletion increases sensitivity to osmostress; expressed at moderate to high abundance; ORF also present in strains EC1118, YJM789, RM11-1a, and AWRI1631; Gln24 in S288C reference is substituted with Arg in wine strain EC1118; predicted S-palmitoylation site on Cys2, suggesting membrane association; transcript previously mischaracterized as SUT646" /codon_start=1 /product="hypothetical protein" /protein_id="DAD54807.1" /db_xref="SGD:S000303810" /translation="MCDDSYDAVEEYYFNKSVAGISGQENWNKQLATQVYSRSLQPEI LPTLKPLSCNKERANAGKRVSEEEQINGKRKRKD" gene 628712..629083 /gene="ABM1" /locus_tag="YJR108W" mRNA 628712..629083 /gene="ABM1" /locus_tag="YJR108W" /product="Abm1p" CDS 628712..629083 /gene="ABM1" /locus_tag="YJR108W" /experiment="EXISTENCE:mutant phenotype:GO:0000226 microtubule cytoskeleton organization [PMID:10628851]" /note="hypothetical protein; required for normal microtubule organization" /codon_start=1 /product="Abm1p" /protein_id="DAA08893.1" /db_xref="SGD:S000003869" /translation="MSWRYSILTVDGSFKIFIPWEIFLTWNFLSAAWLNSTESNTYIH YSTCWGTSDYTLNISVIEATTEKLVDTRLLTTLENATAWINSNSIDEDEDDMPHATNV ADRLDGLSLSKRVYSICHYEF" gene complement(629585..632941) /gene="CPA2" /locus_tag="YJR109C" mRNA complement(629585..632941) /gene="CPA2" /locus_tag="YJR109C" /product="carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2" CDS complement(629585..632941) /gene="CPA2" /locus_tag="YJR109C" /EC_number="6.3.5.5" /EC_number="6.3.4.16" /experiment="EXISTENCE:direct assay:GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [PMID:8626695]" /experiment="EXISTENCE:direct assay:GO:0005951 carbamoyl-phosphate synthase complex [PMID:206535]" /experiment="EXISTENCE:mutant phenotype:GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [PMID:6358221]" /experiment="EXISTENCE:mutant phenotype:GO:0006526 L-arginine biosynthetic process [PMID:8626695]" /note="Large subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor" /codon_start=1 /product="carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2" /protein_id="DAA08894.1" /db_xref="SGD:S000003870" /translation="MTSIYTSTEPTNSAFTTEDYKPQLVEGVNSVLVIGSGGLSIGQA GEFDYSGSQAIKALKEDNKFTILVNPNIATNQTSHSLADKIYYLPVTPEYITYIIELE RPDAILLTFGGQTGLNCGVALDESGVLAKYNVKVLGTPIKTLITSEDRDLFASALKDI NIPIAESFACETVDEALEAAERVKYPVIVRSAYALGGLGSGFANNASEMKELAAQSLS LAPQILVEKSLKGWKEVEYEVVRDRVGNCITVCNMENFDPLGVHTGDSMVFAPSQTLS DEEFHMLRSAAIKIIRHLGVIGECNVQYALQPDGLDYRVIEVNARLSRSSALASKATG YPLAYTAAKIGLGYTLPELPNPITKTTVANFEPSLDYIVAKIPKWDLSKFQYVDRSIG SSMKSVGEVMAIGRNYEEAFQKALRQVDPSLLGFQGSTEFGDQLDEALRTPTDRRVLA IGQALIHENYTVERVNELSKIDKWFLYKCMNIVNIYKELESVKSLSDLSKDLLQRAKK LGFSDKQIAVTINKHASTNINELEIRSLRKTLGIIPFVKRIDTLAAEFPAQTNYLYTT YNATKNDVEFNENGMLVLGSGVYRIGSSVEFDWCAVNTAKTLRDQGKKTIMINYNPET VSTDFDEVDRLYFEELSYERVMDIYELEQSEGCIISVGGQLPQNIALKLYDNGCNIMG TNPNDIDRAENRHKFSSILDSIDVDQPEWSELTSVEEAKLFASKVNYPVLIRPSYVLS GAAMSVVNNEEELKAKLTLASDVSPDHPVVMSKFIEGAQEIDVDAVAYNGNVLVHAIS EHVENAGVHSGDASLVLPPQHLSDDVKIALKDIADKVAKAWKITGPFNMQIIKDGEHT LKVIECNIRASRSFPFVSKVLGVNFIEIAVKAFLGGDIVPKPVDLMLNKKYDYVATKV PQFSFTRLAGADPFLGVEMASTGEVASFGRDLIESYWTAIQSTMNFHVPLPPSGILFG GDTSREYLGQVASIVATIGYRIYTTNETTKTYLQEHIKEKNAKVSLIKFPKNDKRKLR ELFQEYDIKAVFNLASKRAESTDDVDYIMRRNAIDFAIPLFNEPQTALLFAKCLKAKI AEKIKILESHDVIVPPEVRSWDEFIGFKAY" gene 633615..635681 /gene="YMR1" /locus_tag="YJR110W" mRNA 633615..635681 /gene="YMR1" /locus_tag="YJR110W" /product="phosphatidylinositol-3-phosphatase YMR1" CDS 633615..635681 /gene="YMR1" /locus_tag="YJR110W" /EC_number="3.1.3.64" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0046856 phosphatidylinositol dephosphorylation [PMID:15169871]" /experiment="EXISTENCE:mutant phenotype:GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity [PMID:15169871]" /experiment="EXISTENCE:mutant phenotype:GO:0046856 phosphatidylinositol dephosphorylation [PMID:15169871]" /note="Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family" /codon_start=1 /product="phosphatidylinositol-3-phosphatase YMR1" /protein_id="DAA08895.1" /db_xref="SGD:S000003871" /translation="MEYIKIAKVSNVVLHRRGTATQGTLHLTTHHLIFESPQLSTEFW FPYPLIYGVHKNPGSTLLSKLTSTNQIQLEGTDSQNYKLYQGKDLWSFVNIKVIGKDY AVFSLDFGGDLHLQARKVYDSILNLTVLSNITQLYAFIYISNNLERKLPSPDSWDIYD PIKEFRRQGLDSKDETCPWRLSTVNEHYEFCPTYPSKLFVPRSTSDILLKHASKFRSQ KRIPVLTYHHKATDCNILRSSQPLPGLINQRSIQDEKLVWESFNSFCNKDIRRTKHVI VDARPRTNALAQMALGGGTENMDNYNFFLADNNMGVDKSLKLPTVTRLFLGIDNIHIV SNTAAYMTEVICQGGDLNLPLEQNLIRSQKFSNWLKLNTLILKSVDMLLKSIIFNHSN VLVHCSDGWDRTSQVVSLLEICLDPFYRTFEGFMILVEKDWCSFGHRFLERSGHLNSD IRFHDNTMHSNFNDVDTNGDDLDIGVNTQDDYAEDDEGGEDETNLINLSRISKKFNEN FKLNKKSLKFVSPVFQQFLDCVYQLLTQNPDLFEFNERFLRRLVYHLYSCQYGTFLSN SEKEKFQQNLPNKTKSVWDYFRSRRKQFINPNFIQRKRSGMNEHDQNLEEEEKVEWIS PDLKKVQWWWQLYGRKDSEMNDELRHKRDSVPISVDKKSKEHSNSDGGKGLNLSIFGF DMFNRK" gene complement(635855..636706) /gene="PXP2" /locus_tag="YJR111C" mRNA complement(635855..636706) /gene="PXP2" /locus_tag="YJR111C" /product="Pxp2p" CDS complement(635855..636706) /gene="PXP2" /locus_tag="YJR111C" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:27392156]" /note="Peroxisomal matrix protein with naturally active promoter; well-conserved in fungi; localized to peroxisomes under physiological growth conditions; levels of some amino acids are altered upon both knockout and overexpression, suggesting potential involvement of Pxp2p in amino acid metabolism or related cellular metabolic processes (needs further study); GFP-fusion protein displays inherent dual localization with large proportion localizing to cytosol" /codon_start=1 /product="Pxp2p" /protein_id="DAA08896.1" /db_xref="SGD:S000003872" /translation="MNQILNAQRLIQLSQFHPKLKNIWYLVAAATFSVCNEPQEIPKL YHYAMLLSNDNAHMYRFTLASQTIDLLRSELPMRKTLINENYQQPTFFQKQLTAKFRE VILKTGPLAGLPRAINGLTMLKETTPDILVPHLDPIDPWEAAMGNSSPLSETSMRRKH DKTIQERDHTIQNGLRHWNSIYNKVSTRVVNNLNSSYPDLWYYTLVHVYGPLFAFDEI LSAQETSLVIIASLVPQDVNPQLRGHLKGALNIGCDKETVEAVRGLAILISQWCGVSW KSGVVKL" gene 637030..637635 /gene="NNF1" /locus_tag="YJR112W" mRNA 637030..637635 /gene="NNF1" /locus_tag="YJR112W" /product="MIND complex subunit NNF1" CDS 637030..637635 /gene="NNF1" /locus_tag="YJR112W" /experiment="EXISTENCE:direct assay:GO:0000444 MIS12/MIND type complex [PMID:14633972]" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:14657030]" /experiment="EXISTENCE:direct assay:GO:0007059 chromosome segregation [PMID:12455957]" /note="Essential component of the outer kinetochore MIND complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for kinetochore bi-orientation and accurate chromosome segregation; complex consists of Mtw1p, Nnf1p, Nsl1p and Dsn1p; homologous to metazoan CENP-H proteins" /codon_start=1 /product="MIND complex subunit NNF1" /protein_id="DAA08897.1" /db_xref="SGD:S000003873" /translation="MVNSHGIRYIRLKQVFNRALDQSISKLQSWDKVSSCFPQYVNSK QGAINVANCQRQLTEFWTELCQREFKEIMEERNVEQKLNELDELILEAKERYTDRDQD EVNKGPAIDELSSKELVECHLYSQRMHAIHEIDERLAKVNEMNDQLAQELKDLETQVE VEKNEIGKMYDEYLGSHTDQPANVLLVQSLNDMVLELKENY" gene 637790..638168 /locus_tag="YJR112W-A" mRNA join(637790..637809,637859..638168) /locus_tag="YJR112W-A" /product="hypothetical protein" CDS join(637790..637809,637859..638168) /locus_tag="YJR112W-A" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; identified based on homology to Ashbya gossypii" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08898.1" /db_xref="SGD:S000028513" /translation="MVQLRRTITTNKVFQAITSTNDKVAHFVVFMWESWLFVKMFAED IVTFRKLQANKYVLGVLICSLCASVTSEFAQSVVSRGQRVFDVKDIICNFWGSLLGVG IAFYQDR" gene complement(638232..638975) /gene="RSM7" /locus_tag="YJR113C" /gene_synonym="uS7m" mRNA complement(638232..638975) /gene="RSM7" /locus_tag="YJR113C" /gene_synonym="uS7m" /product="mitochondrial 37S ribosomal protein RSM7" CDS complement(638232..638975) /gene="RSM7" /locus_tag="YJR113C" /gene_synonym="uS7m" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S7 ribosomal protein" /codon_start=1 /product="mitochondrial 37S ribosomal protein RSM7" /protein_id="DAA08899.1" /db_xref="SGD:S000003874" /translation="MLHCARRYMLVRPRLLWQSGTCVARFQSSVRTPASEPSAEKGVD EWLEAINELREEFSAKEYLPETSLAPPGQSKVDLLQGSQAGSKIKPTAEQLAQWEALK SVPIPPRKNATLDHITNMIMRHGKKEKAQTILSRALYLVYCQTRQDPIQALEKSLDEL APLMMTKTFNTGVAKASVIPVPLNKRQRNRIAWNWIVQSANQRVSSDFAVRLGEELTA IAKGTSSAFEKRDQIHKTAIAHRAYIQLK" gene 639942..640451 /locus_tag="YJR115W" mRNA 639942..640451 /locus_tag="YJR115W" /product="hypothetical protein" CDS 639942..640451 /locus_tag="YJR115W" /note="hypothetical protein; YJR115W has a paralog, ECM13, that arose from the whole genome duplication" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08900.1" /db_xref="SGD:S000003876" /translation="MFTNTRTILIYNSKVMNTHTHTHTHTHTHIYIYTGDQVSVRGRL LSLKFFKVLKLFFPSPTSLATSHPPLSSMSPYMTIPQQYLYISKIRSKLSQCALTRHH HRELDLRKMVGHANMLDRILDEIDEIDSEVVLCDAADGSSTAEAHSASPASSDSSPLT NNIRPISIM" gene 640825..641664 /gene="TDA4" /locus_tag="YJR116W" mRNA 640825..641664 /gene="TDA4" /locus_tag="YJR116W" /product="Tda4p" CDS 640825..641664 /gene="TDA4" /locus_tag="YJR116W" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Protein distantly similar to ceramide synthases, Lag1p and Lac1p; null mutant is sensitive to expression of the top1-T722A allele; mutation confers sensitivity to copper" /codon_start=1 /product="Tda4p" /protein_id="DAA08901.1" /db_xref="SGD:S000003877" /translation="MNANSTTTAIGLTSPFEKLSFFPHSSNLILAHLHEIIFSFVFYQ LAFSVVAPFLNKVVFRKHYTTIRDPLLKIDFNVHTVSMIQAVVSNTVLLPTLTTPMHY NVVTYTDSYSSMVSSLSAGYFIWDLTMCVRYFKLYGLEFTGHAIGSVYVMLLSLRPFC QPWIGRFLIYEASTPFVNINWFIMQCNAKSKNSIPLWFNVVNGLLLMTVFFVVRICWG SIASALLFRQMWKVRDELPKFSAVTMMSLNIFMNLLNVLWFKKMIRIAKKLAKPAPTS KLD" gene 642007..643368 /gene="STE24" /locus_tag="YJR117W" /gene_synonym="AFC1" /gene_synonym="PIO2" mRNA 642007..643368 /gene="STE24" /locus_tag="YJR117W" /gene_synonym="AFC1" /gene_synonym="PIO2" /product="zinc metalloprotease" CDS 642007..643368 /gene="STE24" /locus_tag="YJR117W" /gene_synonym="AFC1" /gene_synonym="PIO2" /EC_number="3.4.24.84" /experiment="EXISTENCE:direct assay:GO:0004222 metalloendopeptidase activity [PMID:11581258|PMID:27129777]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11581258]" /experiment="EXISTENCE:direct assay:GO:0016485 protein processing [PMID:27129777]" /experiment="EXISTENCE:direct assay:GO:0071432 peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion [PMID:11581258]" /experiment="EXISTENCE:genetic interaction:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:26771486]" /experiment="EXISTENCE:genetic interaction:GO:0036503 ERAD pathway [PMID:26771486]" /experiment="EXISTENCE:genetic interaction:GO:0071432 peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion [PMID:10825201|PMID:9065405|PMID:11581258]" /experiment="EXISTENCE:genetic interaction:GO:0071586 CAAX-box protein processing [PMID:9065405]" /experiment="EXISTENCE:mutant phenotype:GO:0005637 nuclear inner membrane [PMID:18923140]" /experiment="EXISTENCE:mutant phenotype:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:26771486]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:26771486]" /experiment="EXISTENCE:mutant phenotype:GO:0071432 peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion [PMID:10825201|PMID:9065405]" /experiment="EXISTENCE:mutant phenotype:GO:0071586 CAAX-box protein processing [PMID:9065405]" /experiment="EXISTENCE:mutant phenotype:GO:0120236 negative regulation of post-translational protein targeting to membrane, translocation [PMID:32513868]" /note="Highly conserved zinc metalloprotease; component of the ER quality control mechanism that removes faulty proteins clogging translocation channels; inhibits SRP-independent translocation into the ER; has two roles in a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; cleaves isoprenylated and non-prenylated oligopeptides; human homolog ZMPSTE24 implicated in mandibuloacral dysplasia (MAD), and complements the null mutant" /codon_start=1 /product="zinc metalloprotease" /protein_id="DAA08902.1" /db_xref="SGD:S000003878" /translation="MFDLKTILDHPNIPWKLIISGFSIAQFSFESYLTYRQYQKLSET KLPPVLEDEIDDETFHKSRNYSRAKAKFSIFGDVYNLAQKLVFIKYDLFPKIWHMAVS LLNAVLPVRFHMVSTVAQSLCFLGLLSSLSTLVDLPLSYYSHFVLEEKFGFNKLTVQL WITDMIKSLTLAYAIGGPILYLFLKIFDKFPTDFLWYIMVFLFVVQILAMTIIPVFIM PMFNKFTPLEDGELKKSIESLADRVGFPLDKIFVIDGSKRSSHSNAYFTGLPFTSKRI VLFDTLVNSNSTDEITAVLAHEIGHWQKNHIVNMVIFSQLHTFLIFSLFTSIYRNTSF YNTFGFFLEKSTGSFVDPVITKEFPIIIGFMLFNDLLTPLECAMQFVMSLISRTHEYQ ADAYAKKLGYKQNLCRALIDLQIKNLSTMNVDPLYSSYHYSHPTLAERLTALDYVSEK KKN" gene complement(643490..644101) /gene="ILM1" /locus_tag="YJR118C" mRNA complement(643490..644101) /gene="ILM1" /locus_tag="YJR118C" /product="Ilm1p" CDS complement(643490..644101) /gene="ILM1" /locus_tag="YJR118C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:10628851]" /note="hypothetical protein; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth" /codon_start=1 /product="Ilm1p" /protein_id="DAA08903.1" /db_xref="SGD:S000003879" /translation="MAQALNSTNIAFFRVAFLFTIAFFCLKNVNSILQNTYFIVLTQA MNLPQLTLSRYSGQLGLFALLFTLNGVHDLIPLLENNVKYFQSVVPVRLLIFFILTSI SYLWESNFYVHNNSVFIYCFAEVWINFLLYNAIREEKNEEFKRLNQFMVNDEDIEEPQ PFTVKTETTEIIEIINDEENDDEDGKDNDDNNEKGNDDSDAKK" gene complement(644304..646490) /gene="JHD2" /locus_tag="YJR119C" /gene_synonym="KDM5" mRNA complement(644304..646490) /gene="JHD2" /locus_tag="YJR119C" /gene_synonym="KDM5" /product="histone demethylase" CDS complement(644304..646490) /gene="JHD2" /locus_tag="YJR119C" /gene_synonym="KDM5" /EC_number="1.14.11.67" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032453 histone H3K4 demethylase activity [PMID:17310254]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:27325136]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:25248920]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:25248920]" /experiment="EXISTENCE:mutant phenotype:GO:0032453 histone H3K4 demethylase activity [PMID:17369256|PMID:17310254]" /experiment="EXISTENCE:mutant phenotype:GO:0043934 sporulation [PMID:23123093]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:27325136|PMID:23123093]" /experiment="EXISTENCE:mutant phenotype:GO:0060623 regulation of chromosome condensation [PMID:25248920]" /experiment="EXISTENCE:mutant phenotype:GO:0071041 antisense RNA transcript catabolic process [PMID:23123093]" /experiment="EXISTENCE:mutant phenotype:GO:1902275 regulation of chromatin organization [PMID:27325136]" /experiment="EXISTENCE:mutant phenotype:GO:1903047 mitotic cell cycle process [PMID:25248920]" /note="JmjC domain family histone demethylase; promotes global demethylation of H3K4 and represses noncoding intergenic transcription during sporulation; removes methyl groups added by Set1p; phosphorylation by Tpk2p during glycolysis inhibits activity, nuclear localization, chromatin binding and promotes Not4p Ub-mediated degradation; negatively regulated by H3K14 acetylation; regulates sporulation timing by extending period of active transcription; regulates rDNA silencing; human homolog is JARID1C" /codon_start=1 /product="histone demethylase" /protein_id="DAA08904.1" /db_xref="SGD:S000003880" /translation="MEEIPALYPTEQEFKNPIDYLSNPHIKRLGVRYGMVKVVPPNGF CPPLSIDMENFTFQPRIQNLENLDLKNRCRLFFMKQLNNFKRSVKDPSKLILREPYTI VEYSDSTHASEILKKKVYFYDVFSELIKDNRTLTDTTQSFRRKLKFRDISQLRGDISL WRTISKKFNVPIGLLKEIFEKYIASYYIFLHSLNENVHTALHADQYPKSLLSDDEDDF DLGPDSNSGSDFEEDDDDACIVCRKTNDPKRTILCDSCDKPFHIYCLSPPLERVPSGD WICNTCIVGNGYYGFTQDTHDYSLPEFQEYCKRQNSRLLPARKLSIDELEEMFWSLVT KNRRSSLTTVKYGADIHNELPGQITGFPTREFIPKNINGDELIDYLKYCDHPMNLTNL PMAHNSLLPLFKRNISGMTIPWIYIGSLFSTFCWHMEDQYTLSANYQHEGDPKVWYSI PESGCTKFNDLLNDMSPDLFIKQPDLLHQLVTLISPYDPNFKKSGIPVYKAVQKPNEY IITFPKCYHAGFNTGYNFNEAVNFTIDFWLPYGFGAITDYKLTQKACVFDMFDLMINV LDKYNKDTLLFNDAFVRQCYSSLIVFYNTELKRIRKIQAIVPRTTLLEVHTDPNDEDE EYDIFCSQCKTICSIAFVLRKNNYDSIRTYKRHKKNHLSIRQWNELSTTDSKVSILCT QDYLKSIQNLNNSDGEEPYIDDELYFTKSLKDIDSLIKQVGVKLDR" gene 647126..647476 /gene="DMO1" /locus_tag="YJR120W" mRNA 647126..647476 /gene="DMO1" /locus_tag="YJR120W" /product="Dmo1p" CDS 647126..647476 /gene="DMO1" /locus_tag="YJR120W" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:10628851]" /experiment="EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:16251356]" /experiment="EXISTENCE:mutant phenotype:GO:0045333 cellular respiration [PMID:10628851]" /note="hypothetical protein; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p" /codon_start=1 /product="Dmo1p" /protein_id="DAA08905.1" /db_xref="SGD:S000003881" /translation="MRWDVIILYAISRPYATRRTGSHTHPRDSRYIAANQRRPPSACR VGPSPAKQRKDIPIFELLDTTLIKNALFALTSFLYYRTNILTCPFLNFLYLSRTGQLD KFCKDQTVTQILAT" gene 647607..649142 /gene="ATP2" /locus_tag="YJR121W" mRNA 647607..649142 /gene="ATP2" /locus_tag="YJR121W" /product="F1F0 ATP synthase subunit beta" CDS 647607..649142 /gene="ATP2" /locus_tag="YJR121W" /EC_number="7.1.2.2" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:18722382|PMID:15294286]" /experiment="EXISTENCE:direct assay:GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) [PMID:15294286]" /experiment="EXISTENCE:direct assay:GO:0045267 proton-transporting ATP synthase, catalytic core [PMID:15294286|PMID:17082766]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:2529856|PMID:6225776]" /experiment="EXISTENCE:mutant phenotype:GO:0045267 proton-transporting ATP synthase, catalytic core [PMID:6225776]" /experiment="EXISTENCE:mutant phenotype:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:6225776]" /experiment="EXISTENCE:mutant phenotype:GO:0046961 proton-transporting ATPase activity, rotational mechanism [PMID:2529856]" /note="Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated" /codon_start=1 /product="F1F0 ATP synthase subunit beta" /protein_id="DAA08906.1" /db_xref="SGD:S000003882" /translation="MVLPRLYTATSRAAFKAAKQSAPLLSTSWKRCMASAAQSTPITG KVTAVIGAIVDVHFEQSELPAILNALEIKTPQGKLVLEVAQHLGENTVRTIAMDGTEG LVRGEKVLDTGGPISVPVGRETLGRIINVIGEPIDERGPIKSKLRKPIHADPPSFAEQ STSAEILETGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELINNIAKAHGGFSVFT GVGERTREGNDLYREMKETGVINLEGESKVALVFGQMNEPPGARARVALTGLTIAEYF RDEEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGLLQERITTTKK GSVTSVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLDSKSRLLD AAVVGQEHYDVASKVQETLQTYKSLQDIIAILGMDELSEQDKLTVERARKIQRFLSQP FAVAEVFTGIPGKLVRLKDTVASFKAVLEGKYDNIPEHAFYMVGGIEDVVAKAEKLAA EAN" gene 649776..651269 /gene="IBA57" /locus_tag="YJR122W" /gene_synonym="CAF17" mRNA 649776..651269 /gene="IBA57" /locus_tag="YJR122W" /gene_synonym="CAF17" /product="Iba57p" CDS 649776..651269 /gene="IBA57" /locus_tag="YJR122W" /gene_synonym="CAF17" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:18086897]" /experiment="EXISTENCE:mutant phenotype:GO:0106034 protein maturation by [2Fe-2S] cluster transfer [PMID:29343425]" /experiment="EXISTENCE:mutant phenotype:GO:0106035 protein maturation by [4Fe-4S] cluster transfer [PMID:29343425|PMID:18086897]" /note="Protein involved in incorporating iron-sulfur clusters into proteins; mitochondrial matrix protein; involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system" /codon_start=1 /product="Iba57p" /protein_id="DAA08907.1" /db_xref="SGD:S000003883" /translation="MFISRRCRIKGFTLKNLLWFRSSSTRFVSTESPDASAITKPDGI FNYSLLENRTYIRIRGPDTVKFLNGLVTSKLLPHFIKKNLTTVEENEVPTEEGTTKVD PIIPVPEFDARLGNWGLYNEKGIQGPYISRFGLYSAFLNGKGKLITDTIIYPTPVTVS EQISNYPEYLLELHGNVVDKILHVLQTHKLANKIKFEKIDHSSLKTWDVEVQFPNLPK DIENPWFDNLLDPMALPKNSIDANNFAVNVLNSLFNSDPRILGIYVERRTESMSRHYS TFPQSFRVVTSEQVDDLSKLFNFNVFDFPFQVNKKASVQVREIRFQKGLIDSTEDYIS ETLLPLELNFDFFPNTISTNKGCYVGQELTARTYATGILRKRLVPVKLDNYQLLDTDP ERKYAEFHIDNVVEKSLAENEPTLNPFTNKPPERTKRKQRPAGLLISNEGLYGVALLR TEHFSAAFSSDEPVEFYITTTKGENIKITPQKPFWFSDWKNNNGPHK" gene 651901..652578 /gene="RPS5" /locus_tag="YJR123W" mRNA 651901..652578 /gene="RPS5" /locus_tag="YJR123W" /product="ribosomal 40S subunit protein S5" CDS 651901..652578 /gene="RPS5" /locus_tag="YJR123W" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480|PMID:385049]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0030490 maturation of SSU-rRNA [PMID:20419091]" /note="Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7" /codon_start=1 /product="ribosomal 40S subunit protein S5" /protein_id="DAA08908.1" /db_xref="SGD:S000003884" /translation="MSDTEAPVEVQEDFEVVEEFTPVVLATPIPEEVQQAQTEIKLFN KWSFEEVEVKDASLVDYVQVRQPIFVAHTAGRYANKRFRKAQCPIIERLTNSLMMNGR NNGKKLKAVRIIKHTLDIINVLTDQNPIQVVVDAITNTGPREDTTRVGGGGAARRQAV DVSPLRRVNQAIALLTIGAREAAFRNIKTIAETLAEELINAAKGSSTSYAIKKKDELE RVAKSNR" gene complement(652892..654238) /locus_tag="YJR124C" mRNA complement(652892..654238) /locus_tag="YJR124C" /product="hypothetical protein" CDS complement(652892..654238) /locus_tag="YJR124C" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347|PMID:26928762]" /note="hypothetical protein; expression induced under calcium shortage" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08909.1" /db_xref="SGD:S000003885" /translation="MAPEIFVKFKCASRDIKLLWASVFLRLLSYGLTNQVLTLFLNAI NMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSFSENF TLLLVFAIFGVISPSSDEVGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGA IICGIFVDLLKRTGLAATDLQCYKLVFLLYAFFAFCKMVIMLLLSDATELDGHYEHTD CNEETAEPLDVNDETAPLMRQATHPEERSNKLSKETVSVLMKLLVIFMVDSLGSGFMT SGWMVYYYSKQFLMGSLALGTLFFITQLVMASSTIPSSIIARCFGPVRATLLVQIPSG IFSILIPMAKNYLPLSILFLNLHFATTAMDVTPRQILLTNIIKPRDLTKVMGVVNIGK TFARCVGPIFTGILANNNYLWLCYIISGSLVITADLILACMFLGVDAKIKKQMNRH" rep_origin 654375..654614 /note="ARS1020; Autonomously Replicating Sequence" /db_xref="SGD:S000028457" gene complement(654737..655963) /gene="ENT3" /locus_tag="YJR125C" mRNA complement(654737..655963) /gene="ENT3" /locus_tag="YJR125C" /product="Ent3p" CDS complement(654737..655963) /gene="ENT3" /locus_tag="YJR125C" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:12967568]" /experiment="EXISTENCE:direct assay:GO:0030125 clathrin vesicle coat [PMID:12483220]" /experiment="EXISTENCE:direct assay:GO:0030276 clathrin binding [PMID:12967568]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:14630930]" /experiment="EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:14630930]" /experiment="EXISTENCE:genetic interaction:GO:0034498 early endosome to Golgi transport [PMID:20658963]" /experiment="EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:12483220]" /experiment="EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:12967568]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:15107463]" /experiment="EXISTENCE:mutant phenotype:GO:0071985 multivesicular body sorting pathway [PMID:12967568]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12483220]" /note="Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p" /codon_start=1 /product="Ent3p" /protein_id="DAA08910.1" /db_xref="SGD:S000003886" /translation="MSLEDTLANMSLYDAKKYFRKAQNVVFNYTEMEGKVREATNNEP WGASSTLMDQISQGTYNFREREEILSMIFRRFTEKAGSEWRQIYKALQLLDYLIKHGS ERFIDDTRNSINLIRILETFHYIDSQGRDQGINVRTRVKALIELLSDDNKIRAERKKA RETAKKYKGVAGGSASADGSLNSKAGFTSTKVHGISVSADFDSDNEDNEDGSFSQNGY NDNASRATSTPGQGKQEPEDFVDFFSSESSKPSKELIQEDEKKADEEEDDDDEFSEFQ SAVPVTNPANSFNLLNTSPIEGMPATTSSMPFYNSSTTDQGKITPAIAEPKKVDPFSS LFSTAKASAEAPSAPKASQAKAAASNPVSNSTTALSTDQDDDDEFGEMHGGAVQQEQN TNNNHTSSKEIDLLSF" gene complement(656254..658689) /gene="VPS70" /locus_tag="YJR126C" mRNA complement(656254..658689) /gene="VPS70" /locus_tag="YJR126C" /product="putative zinc metalloprotease" CDS complement(656254..658689) /gene="VPS70" /locus_tag="YJR126C" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]" /note="hypothetical protein involved in vacuolar protein sorting; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum" /codon_start=1 /product="putative zinc metalloprotease" /protein_id="DAA08911.1" /db_xref="SGD:S000003887" /translation="MRMIQRERKREKEEGQLKERTVVNMADPDDNEAEATGLQQYSGE TTRDDNEESMNDSFTLTSRNRGRSNTISSIVSGYEIMKEHMDKEKFMYLILASLLLYM GFVAAFAPRTSLSRDFRRFHSSRLTNAEVYRIYLNSLQQENRAKEHVYKYAGYMSNGA SDSSTFKYTLDEFLDMGYKPKVEKYYPWIGEPVDTNVAPLENGKVVYEASMIEDRVKG DPASHARKRQKGFHQYSKNGSVTARYVFCNYGSISDYKLLLKKNIDIEDKIHIVRSGK ILPGLKVKNAELYGASSVIIYTDPFDDGKVTEENGFLHYPYGPARNPSYIRRDSVNYF SDTPGDPTTPGYPSKDSDTEHMSPVGRVPRIPSVPMSARDVQPILERLNGRGFQIGPG SNIKDFGSFTGPSSSIDKVHLHNELTYNIKEMSSVEVSIPGIFTEGEIIIGAHRDSLA SSSAGDANSGSAILLEIARGMSKLLKHGWKPLRPIKLISWDGERSGLLGSTDYAEAHA AILRRRALVYLNLDNAISGTNFHCKANPLLQDVIYEAAKLTEFNGHEDWSLFDHWKYT SNATISLLDGLSSYTSFQYHLGVPAAHFQFNANDTSGAVYHSNSVFDSPTWLEKFTNS DYKLHNTMAMFVGLTTLMLSENELARFNTHVYLKKIYNWYIAWHSNLSSAFPQDDEVN SLAKRVLDLLKVATQEDSIQFDQQNGILYKECREALPVWAFYKKIKSYIKLQRSNSKS KQIDQLFITHRGLKDREWMKYSLLAPSKFEGSVGEVLPGLHEGLADIDRNEVIQWLTI LLSQFSNVRYLLQ" gene complement(658917..663059) /gene="RSF2" /locus_tag="YJR127C" /gene_synonym="ZMS1" mRNA complement(658917..663059) /gene="RSF2" /locus_tag="YJR127C" /gene_synonym="ZMS1" /product="Rsf2p" CDS complement(658917..663059) /gene="RSF2" /locus_tag="YJR127C" /gene_synonym="ZMS1" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:16208474]" /note="Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress" /codon_start=1 /product="Rsf2p" /protein_id="DAA08912.1" /db_xref="SGD:S000003888" /translation="MEPFAFGRGAPALCILTAAARINLDNFVPCCWALFRLSFFFPLD PAYIRNENKETRTSWISIEFFFFVKHCLSQHTFFSKTLAPKRNFRAKKLKDIGDTRID RADKDFLLVPEPSMFVNGNQSNFAKPAGQGILPIPKKSRIIKTDKPRPFLCPTCTRGF VRQEHLKRHQHSHTREKPYLCIFCGRCFARRDLVLRHQQKLHAALVGTGDPRRMTPAP NSTSSFASKRRHSVAADDPTDLHIIKIAGNKETILPTPKNLAGKTSEELKEAVVALAK SNNVELPVSAPVMNDKREKTPPSKAGSLGFREFKFSTKGVPVHSASSDAVIDRANTPS SMHKTKRHASFSASSAMTYMSSSNSPHHSITNFELVEDAPHQVGFSTPQMTAKQLMES VSELDLPPLTLDEPPQAIKFNLNLFNNDPSGQQQQQQQQQQNSTSSTIVNSNNGSTVA TPGVYLLSSGPSLTDLLTMNSAHAGAGGYMSSHHSPFDLGCFSHDKPTVSEFNLPSSF PNTIPSNSTTASNSYSNLANQTYRQMSNEQPLMSLSPKNPPTTVSDSSSTINFNPGTN NLLEPSMEPNDKDSNIDPAAIDDKWLSEFINNSDPKSTFKINFNHFNDIGFIYSPPSS RSSIPNKSPPNHSATSLNHEKASLSPRLNLSLNGSTDLPSTPQNQLKEPSYSDPISHS SHKRRRDSVMMDYDLSNFFSSRQLDISKVLNGTEQNNSHVNDDVLTLSFPGETDSNAT QKQLPVLTPSDLLSPFSVPSVSQVLFTNELRSMMLADNNIDSGAFPTTSQLNDYVTYY KEEFHPFFSFIHLPSIIPNMDSYPLLLSISMVGALYGFHSTHAKVLANAASTQIRKSL KVSEKNPETTELWVIQTLVLLTFYCIFNKNTAVIKGMHGQLTTIIRLLKASRLNLPLE SLCQPPIESDHIMEYENSPHMFSKIREQYNAPNQMNKNYQYFVLAQSRIRTCHAVLLI SNLFSSLVGADCCFHSVDLKCGVPCYKEELYQCRNSDEWSDLLCQYKITLDSKFSLIE LSNGNEAYENCLRFLSTGDSFFYGNARVSLSTCLSLLISIHEKILIERNNARISNNNT NSNNIELDDIEWKMTSRQRIDTMLKYWENLYLKNGGILTPTENSMSTINANPAMRLII PVYLFAKMRRCLDLAHVIEKIWLKDWSNMNKALEEVCYDMGSLREATEYALNMVDAWT SFFTYIKQGKRRIFNTPVFATTCMFTAVLVISEYMKCVEDWARGYNANNPNSALLDFS DRVLWLKAERILRRLQMNLIPKECDVLKSYTDFLRWQDKDALDLSALNEEQAQRAMDP NTDINETIQLIVAASLSSKCLYLGVQILGDAPIWPIILSFAHGLQSRAIYSVTKKRNT RI" gene 662921..663280 /locus_tag="YJR128W" mRNA 662921..663280 /locus_tag="YJR128W" /product="hypothetical protein" CDS 662921..663280 /locus_tag="YJR128W" /note="hypothetical protein; conserved among S. cerevisiae strains; partially overlaps the verified ORF RSF2" /codon_start=1 /product="hypothetical protein" /protein_id="DAA80308.1" /db_xref="SGD:S000003889" /translation="MQGQAGKRKTDGKVPSNTEQNCPDLFERPRLVCIMQAPLVQMRT VPSETGHFPKIISLNRSCSRSYLLSMPHTQLPYPLPYGEFPRCSTVRRDHNFPCTLYS APGVVHPRLCVFSCMMI" gene 663749..663942 /gene="SNR3" /locus_tag="YNCJ0030W" ncRNA 663749..663942 /ncRNA_class="snoRNA" /gene="SNR3" /locus_tag="YNCJ0030W" /product="SNR3" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:3327689]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:3327689]" /experiment="EXISTENCE:mutant phenotype:GO:0000454 snoRNA guided rRNA pseudouridine synthesis [PMID:15306656|PMID:9160748|PMID:15923376]" /experiment="EXISTENCE:mutant phenotype:GO:0030559 rRNA pseudouridylation guide activity [PMID:15306656|PMID:15923376|PMID:9160748]" /experiment="EXISTENCE:physical interaction:GO:0003723 RNA binding [PMID:3327689]" /experiment="EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:9472021|PMID:15923376]" /note="H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at positions U2129, U2133, and U2264" /db_xref="SGD:S000006492" gene complement(664000..665019) /gene="EFM3" /locus_tag="YJR129C" mRNA complement(664000..665019) /gene="EFM3" /locus_tag="YJR129C" /product="protein-lysine N-methyltransferase" CDS complement(664000..665019) /gene="EFM3" /locus_tag="YJR129C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016279 protein-lysine N-methyltransferase activity [PMID:25086354]" /experiment="EXISTENCE:direct assay:GO:0018023 peptidyl-lysine trimethylation [PMID:25086354]" /experiment="EXISTENCE:mutant phenotype:GO:0018023 peptidyl-lysine trimethylation [PMID:25231983|PMID:25086354]" /note="S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which trimethylates translation elongation factor EF2 (Eft1p and Eft2p) at lysine 509; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; ortholog of human gene FAM86A" /codon_start=1 /product="protein-lysine N-methyltransferase" /protein_id="DAA08913.2" /db_xref="SGD:S000003890" /translation="MNEDLFYDRLHQRCPGKYLLEELETSKSNDVLHASRFVCEMELV QKTNAYYCKTIVKMLLDHEWIFAKAFTIVNDGEDEIEIYDYLYEKYIKLLSTGKPDPM MKDVVRYRFDEDVKIKIEETPNLISAASTTGFRTWEAALYMGDFLIHKPLQELAPVQG QDDGKKKLNVLEVGAGTGIVSLVILQKYHEFVNKMYVTDGDSNLVETQLKRNFELNNE VRENEPDIKLQRLWWGSDRVPEDIDLVVGADVTYDPTILPDLCECLAECLALDRCKLC LLSATIRSESTVQLFSQECNKLGLKCTIVTSTEYDANNEIRAMKALQFKPLIAPIRIY KITKQ" gene complement(665218..667137) /gene="STR2" /locus_tag="YJR130C" mRNA complement(665218..667137) /gene="STR2" /locus_tag="YJR130C" /product="cystathionine gamma-synthase" CDS complement(665218..667137) /gene="STR2" /locus_tag="YJR130C" /EC_number="2.5.1.48" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0003962 cystathionine gamma-synthase activity [PMID:10821189]" /experiment="EXISTENCE:mutant phenotype:GO:0006790 sulfur compound metabolic process [PMID:10821189]" /experiment="EXISTENCE:mutant phenotype:GO:0019346 transsulfuration [PMID:10821189]" /note="Cystathionine gamma-synthase, converts cysteine into cystathionine; STR2 has a paralog, YML082W, that arose from the whole genome duplication" /codon_start=1 /product="cystathionine gamma-synthase" /protein_id="DAA08914.1" /db_xref="SGD:S000003891" /translation="MISRTIGESIPPNTKHAVSVCLPTWEATVGYEEGESSIINSLTT GYPRFFIHKSIKKLCEILSAKYSMEDEACLCFPSYKVANRCREFIKVKTGLSTKVRIL QLCTPKPMNQEEKLWRRECKITVVFVDQEIFPVMKQYWQHSGEIVSSRMAEYILHELQ VKDNLKKMETVDNGKKFMTEDENRVNEEYIETRFGRNLNFLAADKAKYLIRKRIATKV VEKIDSEGLSDLFSFEHYNESNGPFNVGSGEALDDDQLNSDIPAETITSMGESGSNST FENTATDDLKFHVNPNTDVYLFPSGMASIFTAHRLLLNFDAKRLSRSSSRQDKLIGYG PPFKKTVMFGFPYTDTLSILRKFNHTHFLGQGDSTSMNALKNILHSGEQILAVFIEAP SNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPYADIVCSSLTKIFSGDSN VIAGSLVLNPRGKIYEFARKFMKTEDGYEDCLWCEDALCLERNSRDFVERTIKVNTNT DILLKRVLLPQVGKLFKKIYYPSLTSEDTKRNYDSVMSTKDGGYGGLFSLTFFNIEEA KKFFNNLELCKGPSLGTNFTLACPYAIIAHYQELDEVAQYGVETNLVRVSVGLENSDV LCNVFQRAIEKALGE" gene 667644..669293 /gene="MNS1" /locus_tag="YJR131W" mRNA 667644..669293 /gene="MNS1" /locus_tag="YJR131W" /product="mannosyl-oligosaccharide 1,2-alpha-mannosidase" CDS 667644..669293 /gene="MNS1" /locus_tag="YJR131W" /EC_number="3.2.1.113" /experiment="EXISTENCE:direct assay:GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [PMID:8910350]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:8864657]" /experiment="EXISTENCE:mutant phenotype:GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [PMID:8439291|PMID:1714453]" /experiment="EXISTENCE:mutant phenotype:GO:0035977 protein deglycosylation involved in glycoprotein catabolic process [PMID:9732283]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:8905927]" /note="Alpha-1,2-mannosidase; involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation" /codon_start=1 /product="mannosyl-oligosaccharide 1,2-alpha-mannosidase" /protein_id="DAA08915.1" /db_xref="SGD:S000003892" /translation="MKNSVGISIATIVAIIAAIYYVPWYEHFERKSPGAGEMRDRIES MFLESWRDYSKHGWGYDVYGPIEHTSHNMPRGNQPLGWIIVDSVDTLMLMYNSSTLYK SEFEAEIQRSEHWINDVLDFDIDAEVNVFETTIRMLGGLLSAYHLSDVLEVGNKTVYL NKAIDLGDRLALAFLSTQTGIPYSSINLHSGQAVKNHADGGASSTAEFTTLQMEFKYL AYLTGNRTYWELVERVYEPLYKNNDLLNTYDGLVPIYTFPDTGKFGASTIRFGSRGDS FYEYLLKQYLLTHETLYYDLYRKSMEGMKKHLLAQSKPSSLWYIGEREQGLHGQLSPK MDHLVCFMGGLLASGSTEGLSIHEARRRPFFSLSLERKSDWDLAKGITDTCYQMYKQS SSGLAPEIVVFNDGNIKQDGWWRSSVGDFFVKPLDRHNLQRPETVESIMFMYHLSHDH KYREWGAEIATSFFENTCVDCNDPKLRRFTSLSDCITLPTKKSNNMESFWLAETLKYL YILFLDEFDLTKVVFNTEAHPFPVLDEEILKSQSLTTGWSL" gene 669522..672668 /gene="NMD5" /locus_tag="YJR132W" /gene_synonym="KAP119" mRNA 669522..672668 /gene="NMD5" /locus_tag="YJR132W" /gene_synonym="KAP119" /product="Nmd5p" CDS 669522..672668 /gene="NMD5" /locus_tag="YJR132W" /gene_synonym="KAP119" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9852143]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:9852143]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0061608 nuclear import signal receptor activity [PMID:9852143]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:9755161]" /experiment="EXISTENCE:mutant phenotype:GO:0061608 nuclear import signal receptor activity [PMID:9755161]" /note="Karyopherin; a carrier protein involved in nuclear import of proteins; importin beta homolog" /codon_start=1 /product="Nmd5p" /protein_id="DAA08916.2" /db_xref="SGD:S000003893" /translation="MDITELLQCFACTLDHNAAVRTNAETHLKNASKVPGFLGACLDI IAADEVPENIKLSASLYFKNKITYGWSAGARQGSNELLDSHVDPDEKPVVKDMLIKTM VSVSKTSPRCIRVLKSALTVIISEDYPSKKWGNLLPNSLELLANEDITVTYVGLLCLA EIFRTYRWKNNDERQDLEELILNYFPALLNYGANVLFQDGKYMNNEQIGELVKLIIKI YKFVSYHDLPFTLQRSESFTPWACFFVSIIQQPLPQEVLAISDIEVRSKNPWVKCKKW ALANLYRLFQRYASTSLTRKFQYDEFKQMYCEEFLTQFLQVVFDQIEKWGTGQLWLSD ECLYYILNFVEQCVVQKTTWKLVGPHYNVILQHVIFPLLKPTAETLEAFDNDPQEYIN RNMDFWDVGYSPDLAALALLTTCVTKRGKTTLQPTLEFMVSTLQSAVGDYNNIMLDNA LQIESCLRIFSSIIDRLITKDSPFASEMEKFILTYVLPFFKSQYGFLQSRVCDICSKL GSMDFKDPVITSTIYEGVMNCLNNSSNSLPVELTAALALQTFISDDQFNMKLSEHVVP TMQKLLSLSNDFESDVISGVMQDFVEQFAEQLQPFGVELMNTLVQQFLKLAIDLHETS NLDPDSFTNVDSIPDESDKQMAALGILSTTISILLSFENSPEILKNLEQSFYPAAEFI LKNDIEDFYRECCEFVENSTFLLRDITPISWKILELIGECNRKPDSMVSYYLSDFMLA LNNILIYGRNELKKNEFYTKIIFEIYQKAVTAEDNSLDDLRVVFDLSQELVLALDDSL PQQYRERLLADVVGSILTQKNELKTNVVFSVTAFNVVISNMITEPLITLQYLKQQGCL EIFFQTWITDYIPNYKRCYDIKLSVLALLKIILKLESNDYSVLNLENLVPQLGSIVTQ LASRLPTALRQLANQRKEFSSSGFEEDTKWDENFLDVGDDDENDDEGDLTEKYLELIK NRADSLDFVDGYDAKETFDDLEEDPLTGSILDTVDVYKVFKESIANLQHVDSNRYQGI LRHLTPADQELFMGIMNA" gene 672991..673620 /gene="XPT1" /locus_tag="YJR133W" mRNA 672991..673620 /gene="XPT1" /locus_tag="YJR133W" /product="xanthine phosphoribosyltransferase" CDS 672991..673620 /gene="XPT1" /locus_tag="YJR133W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0004422 hypoxanthine phosphoribosyltransferase activity [PMID:10217799]" /experiment="EXISTENCE:genetic interaction:GO:0046100 hypoxanthine metabolic process [PMID:10217799]" /experiment="EXISTENCE:mutant phenotype:GO:0000310 xanthine phosphoribosyltransferase activity [PMID:10217799]" /experiment="EXISTENCE:mutant phenotype:GO:0032265 XMP salvage [PMID:10217799]" /note="Xanthine-guanine phosphoribosyl transferase; required for xanthine utilization and for optimal utilization of guanine" /codon_start=1 /product="xanthine phosphoribosyltransferase" /protein_id="DAA08917.1" /db_xref="SGD:S000003894" /translation="MAENERMYISYNNIHKLCQGVAKHILARNERPDIIIAITGGGMI PARIIRSFLKTKGQKNIPIQAIGLSLYEDLGLDNSVETIGKEVIRTQWLDFGALNQHF DSLIGKKVLIVDEVDDTRTTLHYAVSELEKEIAEQQKVLNRMSEETVISIFVLHNKDK PKRAGLPDSMMNSGRYIAAQTVPDKWLCYPWDAEDIEEHTMLAKAQGHD" gene complement(673729..675852) /gene="SGM1" /locus_tag="YJR134C" mRNA complement(673729..675852) /gene="SGM1" /locus_tag="YJR134C" /product="Sgm1p" CDS complement(673729..675852) /gene="SGM1" /locus_tag="YJR134C" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]" /note="hypothetical protein; required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus" /codon_start=1 /product="Sgm1p" /protein_id="DAA08918.1" /db_xref="SGD:S000003895" /translation="MSKKLSLEERLSLATKKGRKKNKRSTSNLSSPSPVVLSNNEQES ARTSIDDAAAGVVSIDNAENIDDPAVRSESTVEGDTGKADSIAVDDVVHPDHNRTDCF DDTMVSLPTWLPKNYTEFTVEELVKEISPEYLRLNKQIDDLTNELNRKSQIETTDSSF FKLIKEKDDLIDQLRKEGAKLAETELRQSNQIKALRTKVKDLEYEVSELNDSSAQSVE NYNELQSLYHNIQGQLAEATNKLKDADKQKESLETLEKNIKEKDDLITILQQSLDNMR TLLEKEKSEFQTEKKALQEATVDQVTTLETKLEQLRIELDSSTQNLDAKSNRDFVDDQ QSYEEKQHASFQYNRLKEQLESSKANWDSIEYALNTKIVNLENRFESTMKEKNDIEEK YQTALRSSETLGKQLEKEKENHSKAVLEVKDLERRAETLKSSLQSISDDYNLLKKKYE IQRSQLEQKENELKPHQENSNEKIIDKIPVELTDSLNSMEGNIEDEWTLPQENSMLSL SMSKLGELESDPSLKPIYNESHETICSEESQHFDRKNVDFSIDDIPEEAAALQAIREG ESMNSLNNTSIPYRRASVQLSNSNGHISAHLVNKLSTELKRLEGELSASKELYDNLLK EKTKANDEILRLLEENDKFNEVNKQKDDLLKRVEQMQSKLETSLQLLGEKTEQVEELE NDVSDLKEMMHQQVQQMVEMQGKMR" gene complement(676059..676778) /gene="MCM22" /locus_tag="YJR135C" mRNA complement(676059..676778) /gene="MCM22" /locus_tag="YJR135C" /product="Mcm22p" CDS complement(676059..676778) /gene="MCM22" /locus_tag="YJR135C" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11782448]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:11782448]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:19730685]" /note="Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4" /codon_start=1 /product="Mcm22p" /protein_id="DAA08919.1" /db_xref="SGD:S000003896" /translation="MDVEKDVLDVYIKNLENQIGNKRYFLKQAQGAIDEITKRSLDTE GKPVNSEVFTELLRKPMFFSERADPIGFSLTSNFLSLRAQSSSEWLSLMNDQSVDQKA MLLLQNNINSDLKELLRKLQHQMTIMDSKKQDHAHIRTRKARNKELWDSLADFLKGYL VPNLDDNDESIDSLTNEVMLLMKRLIEHDLNLTLNDFSSKTIPIYRLLLRANIITVIE GSTNPGTKYIKLIDFNETSLT" gene 676971..677234 /gene="TIM8" /locus_tag="YJR135W-A" mRNA 676971..677234 /gene="TIM8" /locus_tag="YJR135W-A" /product="protein transporter TIM8" CDS 676971..677234 /gene="TIM8" /locus_tag="YJR135W-A" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0042719 mitochondrial intermembrane space protein transporter complex [PMID:12221072]" /experiment="EXISTENCE:direct assay:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:10051608|PMID:10469659]" /experiment="EXISTENCE:direct assay:GO:0140318 protein transporter activity [PMID:10469659|PMID:10051608]" /experiment="EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:10469659]" /experiment="EXISTENCE:mutant phenotype:GO:0140318 protein transporter activity [PMID:10469659]" /experiment="EXISTENCE:physical interaction:GO:0042719 mitochondrial intermembrane space protein transporter complex [PMID:10051608]" /note="Mitochondrial intermembrane space protein; forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome, also known as deafness-dystonia-optic neuronopathy (DDON) syndrome; human TIMM8A can complement yeast null mutant" /codon_start=1 /product="protein transporter TIM8" /protein_id="DAA08920.1" /db_xref="SGD:S000007348" /translation="MSSLSTSDLASLDDTSKKEIATFLEGENSKQKVQMSIHQFTNIC FKKCVESVNDSNLSSQEEQCLSNCVNRFLDTNIRIVNGLQNTR" gene complement(677441..678706) /gene="TTI2" /locus_tag="YJR136C" mRNA complement(677441..678706) /gene="TTI2" /locus_tag="YJR136C" /product="Tti2p" CDS complement(677441..678706) /gene="TTI2" /locus_tag="YJR136C" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0110078 TTT Hsp90 cochaperone complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:27172216]" /experiment="EXISTENCE:mutant phenotype:GO:0031669 cellular response to nutrient levels [PMID:27172216]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:27172216]" /experiment="EXISTENCE:mutant phenotype:GO:0071472 cellular response to salt stress [PMID:27172216]" /note="Subunit of the TTT complex and regulator of telomere length; subunit of the TTT Hsp90 cochaperone complex that is involved in chromatin remodeling and telomeric chromatin regulation; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; involved in the cellular stress response; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasm; similar to S. pombe Tti2p" /codon_start=1 /product="Tti2p" /protein_id="DAA08921.1" /db_xref="SGD:S000003897" /translation="MTAVTDIIDELNDSSLSSTRLRELCLQLRKKTDTGCAITVSDEV NLIESLSYHSISPGVDIQINTDVLQTIDYYFQRNKSEHDEIMCVLISKLQPLLLKRKS NFELKEQRNLGLKPTLGMSLKEDNLMQAWVSQGGLKGIPLFYVILLHLKRRDISTNLS WIIPGILNILDDTTDIRRIKLRGVLLLQTLLNHTFMNETNDSKWIQFSSTGLFPLFEK TLINMCYFLPPSYNADETIAIWRVVFPTIQSLYKVEFLDNYTKYQYHLEKFMSEIILQ NIIPRASLAYENLTLYALECTMNILRLQREGSVVHLQRLIFVLGEYIVRNPFYTTFPK LISKTLSVVSTLIKVCPNERIVAHRFDILSLILVTYDKCSQEDALNESILQQCKETIS WLLNCDCAMGEQLSTLSKQPRFQLLFEFS" gene complement(678957..683285) /gene="MET5" /locus_tag="YJR137C" /gene_synonym="ECM17" mRNA complement(678957..683285) /gene="MET5" /locus_tag="YJR137C" /gene_synonym="ECM17" /product="sulfite reductase (NADPH) subunit beta" CDS complement(678957..683285) /gene="MET5" /locus_tag="YJR137C" /gene_synonym="ECM17" /EC_number="1.8.1.2" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004783 sulfite reductase (NADPH) activity [PMID:6751400]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0009337 sulfite reductase complex (NADPH) [PMID:6751400|PMID:9003798]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000097 sulfur amino acid biosynthetic process [PMID:1479340]" /experiment="EXISTENCE:mutant phenotype:GO:0000103 sulfate assimilation [PMID:19236486]" /note="Sulfite reductase beta subunit; involved in amino acid biosynthesis, transcription repressed by methionine" /codon_start=1 /product="sulfite reductase (NADPH) subunit beta" /protein_id="DAA08922.1" /db_xref="SGD:S000003898" /translation="MTASDLLTLPQLLAQYSSSAPQNKVFYTTSTKNSHSSFKGLESV ATDATHLLNNQDPLNTIKDQLSKDILTTVFTDETTLVKSIHHLYSLPNKLPLVITVDL NLQDYSAIPALKDLSFPILISSDLQTAISNADSSYKIATSSLTPVFHFLNLEKIGTST AIEQDIDFPTLEIANEETKVALSEATDSLTNFELVKGKESITTVIVNLSPYDAEFSSV LPSNVGLIKIRVYRPWNFSKFLEILPSSVTKIAVLQGVSKKSQSNEFQPFLLDFFGNF NELVSRNIEQVVLTNIGNVNDYGNVINTVISNINKKEPDNNLFLGESNEKAEEQAEVT QLISSVKKVVNLEDAYIKVLKQLFSSNLQILNQFSSETIEPSNPEFGFGRFLKQEAQR EELISLAKTSLDPSLYLSEDANKIVQLLSKWLSFNGRDLDEAQLQEANATGLEIFQLL QSNQDSSTVLKFLKIAPTSDSFIFKSSWLIGSDAWSYDLGHSGIQQVLSSRKNINVLL IDSEPYDHRKQNQDRKKDVGLYAMNYYSAYVASVAVYASYTQLLTAIIEASKYNGPSI VLAYLPYNSENDTPLEVLKETKNAVESGYWPLYRFNPVYDDPSTDKEAFSLDSSVIRK QLQDFLDRENKLTLLTRKDPSLSRNLKQSAGDALTRKQEKRSKAAFDQLLEGLSGPPL HVYYASDGGNAANLAKRLAARASARGLKATVLSMDDIILEELPGEENVVFITSTAGQG EFPQDGKSFWEALKNDTDLDLASLNVAVFGLGDSEYWPRKEDKHYFNKPSQDLFKRLE LLSAKALIPLGLGDDQDADGFQTAYSEWEPKLWEALGVSGAAVDDEPKPVTNEDIKRE SNFLRGTISENLKDTSSGGVTHANEQLMKFHGIYTQDDRDIREIRKSQGLEPYYMFMA RARLPGGKTTPQQWLALDHLSDTSGNGTLKLTTRATFQIHGVLKKNLKHTLRGMNAVL MDTLAAAGDVNRNVMVSALPTNAKVHQQIADMGKLISDHFLPKTTAYHEVWLEGPEEQ DDDPSWPSIFENRKDGPRKKKTLVSGNALVDIEPIYGPTYLPRKFKFNIAVPPYNDVD VLSIDVGLVAIVNPETQIVEGYNVFVGGGMGTTHNNKKTYPRLGSCLGFVKTEDIIPP LEGIVIVQRDHGDRKDRKHARLKYTVDDMGVEGFKQKVEEYWGKKFEPERPFEFKSNI DYFGWIKDETGLNHFTAFIENGRVEDTPDLPQKTGIRKVAEYMLKTNSGHFRLTGNQH LVISNITDEHVAGIKSILKTYKLDNTDFSGLRLSSSSCVGLPTCGLAFAESERFLPDI ITQLEDCLEEYGLRHDSIIMRMTGCPNGCSRPWLGELALVGKAPHTYNLMLGGGYLGQ RLNKLYKANVKDEEIVDYIKPLFKRYALEREEGEHFGDFCIRVGIIKPTTEGKYFHED VSEDAY" rep_origin 684009..684098 /note="ARS1021; Autonomously Replicating Sequence" /db_xref="SGD:S000007553" gene 684567..689321 /gene="IML1" /locus_tag="YJR138W" /gene_synonym="SEA1" mRNA 684567..689321 /gene="IML1" /locus_tag="YJR138W" /gene_synonym="SEA1" /product="GTPase-activating protein IML1" CDS 684567..689321 /gene="IML1" /locus_tag="YJR138W" /gene_synonym="SEA1" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:23716719]" /experiment="EXISTENCE:direct assay:GO:0035859 Seh1-associated complex [PMID:21454883]" /experiment="EXISTENCE:direct assay:GO:1990130 GATOR1 complex [PMID:21900499]" /experiment="EXISTENCE:genetic interaction:GO:0032007 negative regulation of TOR signaling [PMID:23716719]" /experiment="EXISTENCE:genetic interaction:GO:0051058 negative regulation of small GTPase mediated signal transduction [PMID:23716719]" /experiment="EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:23716719]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:25046117]" /experiment="EXISTENCE:mutant phenotype:GO:0010508 positive regulation of autophagy [PMID:25046117]" /experiment="EXISTENCE:mutant phenotype:GO:0032007 negative regulation of TOR signaling [PMID:23974112]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:35158208]" /experiment="EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:23716719]" /experiment="EXISTENCE:mutant phenotype:GO:2000785 regulation of autophagosome assembly [PMID:21900499]" /note="GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy, and is a subcomplex of the SEA, a coatomer-related complex that associates with the vacuole; Iml1p functions as a GAP for the Rag family GTPase Gtr1p (EGOC subunit) in SEACIT, resulting in the inhibition of TORC1 signaling in response to amino acid deprivation; role in the oxidative stress response" /codon_start=1 /product="GTPase-activating protein IML1" /protein_id="DAA08923.1" /db_xref="SGD:S000003899" /translation="MFAKLHGKKQRPISSINSQTPRTSNTTHANSISLSSGNLIVGSN RNLRQKKEQFGSQQRASGRKLISNKENDDNVNNGGDNNYDNGERVHRHHIPGLKIKAY QAELGYHESRFSENLVMLNLVEFPDIKPGDLVELKTYHKNPSASNGDKKIYFIAKDFD GETKRRAKTSNVSILSGQLQTLLDLPSRSRIWIKLKPNKFDLQADVVEFNIKDCLLNR GDMWVLSSKLVDTCVFMDQRLAFLDSIRGTIKGIYRNGKKIVSGYIGEQTRIIFRSES ARLIFLIQITDEMWNFEETGEQLFQKMVNSFFPKIFKKWKDVDTHHTITIAFAISMDL SDTSFKDLTPGESLKNSQDYFRIVVDQVSIIHWVDIMETLREEFMEIRKDLLNKQTDK GYSVANGRFSPVIKSNFLELVNFATTILTDPFKQLDLRHTTTHVMIISPGSGLFDVDY SLLRLTGKKLLSLEMTMDLICLSKAPLHIVPLFRYRDFENKLHHCVPLWLSVFFWNDH DKKSNSEWTPRCKIYDLQMMGITENELIREVDVEYLQLNKKVKSLSEFMNDYDKNAFE VKILCAGSNTKQSKKLNSKFDTVFENDVVVKARKIPATATTTHGNTKFIWRGPKVALP AIKDIQKPNVIPDLSIKTIEASFYDDCNTTNDKISTPTTSNNDNLEMNDSLVSVRSAD NQNTSLALDSLKGLSKRNSLKDFTQRVITKFISNIDTSKNKKIKSTLLRDDVDNSPLG SNTPLPSSESKISGLKLQQKGLADENVISKRGNLIIKKNLSIFGLPSNEIMSGSPSSY LGSSHTRTSSKLSNMSDKAAFITEGQKSKHDDSNTYSLTQQLKHRISETWVDIKSPSI PVSSEFANELLPIRWKDVWPKYVARKYSKWRSFTTPAELPITISDFPSKDDFDRNFIF RNHSVTLNTDQEQYNQTYKDLLRDMIYMRLLTGFQICVGRQVEKIELSRESGESETVV NKYLDFNQNDAFKLYLMIDSEIHRITCSSSGIIDVERYLRKDEANLFDQVPSYIPLVK TRYESSFRDAMIDPLHVKRESLNWNQIDQVLAGYGDNLIDRKWHGFRAKYVVLPTDIP PNTYSMVINGKSETLNPEEIRVEGLRRLIGSITRSRLRTEKEKKGRKTKREEIQPEVM FYTGPLYNFINEQQTSLESSAINFKDSIFVNDNNLLNRNVELSKLAYQIQRGEDRITL VNRKWHWKKHEKCFVGSEMVNWLIRNFSDIDTREDAIKYGQKVMKEGLFVHVLNKHNF LDGHYFYQFSPEYVMDTNKLEKTNSHRSTLSDPKQMLRKASTGSSNDPSAMTPFSSVV PAISASNASVADAKEPSRPILMLSNSLVIDVDPAGKSSKQESCTVHYDRVHNPDHCFH IRLEWLTTTPKLIDDLVGNWSRLCERYGLKMIEIPWEELCTIPSVNPFHSFVEIKLAI NPWEDPEFKDRELFAKSKFYYHVYLLKASGFLLDNRASKFLQNQDIEFDIMYSWGKPQ FKYVQYIHHTGAYVAELRENGCLFLAPNNIYISRVNPGNIIGKIHSASSSSLDAQKVI LNFKSTCLDYQKLRSIFLDAKEMWITGKIVED" gene complement(689445..690524) /gene="HOM6" /locus_tag="YJR139C" /gene_synonym="THR6" mRNA complement(689445..690524) /gene="HOM6" /locus_tag="YJR139C" /gene_synonym="THR6" /product="homoserine dehydrogenase" CDS complement(689445..690524) /gene="HOM6" /locus_tag="YJR139C" /gene_synonym="THR6" /EC_number="1.1.1.3" /experiment="EXISTENCE:direct assay:GO:0004412 homoserine dehydrogenase activity [PMID:11341915]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0009086 methionine biosynthetic process [PMID:4380684]" /experiment="EXISTENCE:mutant phenotype:GO:0009088 threonine biosynthetic process [PMID:4380684]" /experiment="EXISTENCE:mutant phenotype:GO:0009090 homoserine biosynthetic process [PMID:4380684]" /note="Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase); dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions" /codon_start=1 /product="homoserine dehydrogenase" /protein_id="DAA08924.1" /db_xref="SGD:S000003900" /translation="MSTKVVNVAVIGAGVVGSAFLDQLLAMKSTITYNLVLLAEAERS LISKDFSPLNVGSDWKAALAASTTKTLPLDDLIAHLKTSPKPVILVDNTSSAYIAGFY TKFVENGISIATPNKKAFSSDLATWKALFSNKPTNGFVYHEATVGAGLPIISFLREII QTGDEVEKIEGIFSGTLSYIFNEFSTSQANDVKFSDVVKVAKKLGYTEPDPRDDLNGL DVARKVTIVGRISGVEVESPTSFPVQSLIPKPLESVKSADEFLEKLSDYDKDLTQLKK EAATENKVLRFIGKVDVATKSVSVGIEKYDYSHPFASLKGSDNVISIKTKRYTNPVVI QGAGAGAAVTAAGVLGDVIKIAQRL" gene complement(690750..695696) /gene="HIR3" /locus_tag="YJR140C" /gene_synonym="HPC1" mRNA complement(690750..695696) /gene="HIR3" /locus_tag="YJR140C" /gene_synonym="HPC1" /product="Hir3p" CDS complement(690750..695696) /gene="HIR3" /locus_tag="YJR140C" /gene_synonym="HPC1" /experiment="EXISTENCE:direct assay:GO:0000417 HIR complex [PMID:16264190|PMID:16303565]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:16264190]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9001207]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:16264190|PMID:16303565]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:16449659]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:1406694]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:1406694]" /experiment="EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:9001207]" /experiment="EXISTENCE:mutant phenotype:GO:0031491 nucleosome binding [PMID:16264190]" /experiment="EXISTENCE:physical interaction:GO:0000417 HIR complex [PMID:16264190]" /note="Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein" /codon_start=1 /product="Hir3p" /protein_id="DAA08925.1" /db_xref="SGD:S000003901" /translation="MSMFNALNSNIEGEQYEAEEHSRELQIEQSFNILQDALIDLKNK DFEKSDSKFQELFQIDVVKPDRWGMYRNSSPTLDNLRYLCYRNRGMYYHLYLENNYER LNSQELVNCILKAVENLVESIQHSDADFAVTDLLARIFKSFNSVKLERLISEYEFTKQ ENLSLLLGRHRKFLLNDLTLMMNNYVELTNKLLVPNLSDNTIFERYHLEKYKDIKPEP LAFGPILSRISEMKKQDEEIMKKLDVFNVTLNEESWDEVAKALKNLLPSVKTSSLIGR NMDPYNEIEEPIEAVKFELSEAINNTPSLDRESERQEEEQDNESVRADDKSGNLAPSD IQTNEEARPNKRTDEHIDSTKPLQRSSKRFKEREQENSKELVMDVHKRFFGEFNTLLS YIHILPFCDFDTFASKFIIGSSDKQPEKFIPYTDLYECLKSWSSRYTDIFNQNDYLSS GSNENEELFQLNALLKSNAFDDKESFPRYLNDLDSDHIRSFISEVNAGNLHFHQVRLK LLFKLLGTYDEGNGRRLIIDYLWESQLLKIVLWFVFGIESNIFALINKNKRQCKYLAL SIYELLVNHLGNIVEEITNKRIQGHKSADLKSQRNKVEKRIRSWHTLLEQIADEKDKE LYVHFQWTHYCFLQYTCDIVDSRLSETLTSLENTIKDSDSSLDIAYPNYRHIPALNLN TVQSQKRKIRIIQNITVEDISEDTNSDTHSENHLETLEKVLLHILHPSTNHSNIDEEM VSFIFNSPFLLKIRLWGVLFSSYVKKSSIQDVQRIYFHVLDFMKGALTSPVYKESNPH GRHQMLLTVLTAIGYLSSQLTAILNSNRWESSDFVLEDYMFEKLLQTFFFFYTVLFYE SSAVNDVSNKSFFKRASKSSGKMKDIMIDLATLILYYYDLQAKLRTPAEQGIETTELI WSLHTLFGHFHFCDASNGKFLDLAEKLLCQFINNDSFLQLKQILWCRYHYAIASDNFS PDLHDTKAVEMEKIHSLPLGTYLIKLQYQNKNPYLSSSKTTLKQIMDNIIEKIGDPST LDNHIISRNSFLLNEYLSRPITADLLKHTFSGATSLYLTSPNDELQQGMTAGLFYVSS LQSLGLYKMRKKSMQARPSELDSIIRMLKNDIIYNTNRFESWILLGKCYSYIVEDDLI WTSDKITVPEKKDVIALTQRKAILCYLMAISIYYSKLDRTIDDKKIILEALDDLGSML ISGYYNPMNKLCFSWKSSAENTMRLSETGEVVMEKTKKITTISDFNIEQSIFLCFNRA CSLSGDIKSQDDVFVLNWSSFYNLAKFFFKTDGGNNCKLVAKYITQGCQIAYESSPAK DPIIEPHYLLVNACYKWVKRGVIGVNEALTLLSKDNQFFQEQEEFWVNDEGLAWDYQE KFFFDKIIRLLRHLLSVDKKKWQHRPRYRIARILFDDLGDVNGALEEMDSLISAKSIN KNLVNIWKPDFERPGKHFIYTYQYLVLYLDLLFAIKDFNTTGLVIKKLRRFGSGTVNV NELLERAINVYTQSAKIKLQLQDKSYVEQILPTLNYQEFLKISEQLNQVFDQGKYPEE ISSGLKLAFQLKKGHSGIAFDSVCLGIYFEYLYFPLARQDQSLTDVNDENNPALPSSG SVTSKSTPDPTSKPSAIKKRVTKKEVFDRVRLLVDKIT" gene 695906..696949 /gene="IPA1" /locus_tag="YJR141W" mRNA 695906..696949 /gene="IPA1" /locus_tag="YJR141W" /product="putative polyadenylation protein" CDS 695906..696949 /gene="IPA1" /locus_tag="YJR141W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:29519818]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:29519818]" /experiment="EXISTENCE:mutant phenotype:GO:0031397 negative regulation of protein ubiquitination [PMID:32009536]" /experiment="EXISTENCE:mutant phenotype:GO:0031442 positive regulation of mRNA 3'-end processing [PMID:32009536]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:29519818]" /experiment="EXISTENCE:physical interaction:GO:0031624 ubiquitin conjugating enzyme binding [PMID:29519818]" /note="Protein implicated in pre-mRNA processing and proteasomal degradation; interacts physically and genetically with mRNA cleavage and polyadenylation factors; mutant is impaired in pre-mRNA cleavage and polyadenylation; associates with several Ub-conjugating enzymes and alters Ub-mediated proteasome activity; localizes to both the nucleus and cytosol; contains a HECT_2 domain; homologous to human ubiquitin-protein ligase, UBE3D, a gene implicated in age-related macular degeneration" /codon_start=1 /product="putative polyadenylation protein" /protein_id="DAA08926.1" /db_xref="SGD:S000003902" /translation="MVQYVVEWLPRIQSISVVVEGWKQVEIKNLKDTLMSISGDEEQV EDILLPVEVEEKVDASYKFKNRGKDLEWMTKLRSKSSKIYDSSIMSLPDGRWTKEELR SDSDFSIECLNCKQKIISKDNCQVLNDMPSEFWFELMDYWHCHKPDVKEDKSSYTRFE TLKPSKNEILIGSSYFQGTPATFENVATTKENDNVLCIKCSAVLGQVTAGSLYKLHKW KLQLIRSGNTYKFPPECDITISLINVVKANSCRYVLVKCKTESLLVWIFSVDIGVTLT GNKSFKRAMKLLYTNSVTTINRCLNRQVVEELDFQETSFNAFYSALQHTNALLPSSMK KIGEWTISYTSLI" gene 697141..698169 /locus_tag="YJR142W" mRNA 697141..698169 /locus_tag="YJR142W" /product="hypothetical protein" CDS 697141..698169 /locus_tag="YJR142W" /experiment="EXISTENCE:direct assay:GO:0044715 8-oxo-dGDP phosphatase activity [PMID:23834287]" /note="8-oxo-dGTP diphosphatase of the Nudix hydrolase family; converts diphosphates of damaged forms of thiamin to monophosphates; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08927.1" /db_xref="SGD:S000003903" /translation="MKVEKSSKGLEVLVRTQEDDLEGFSFLEIMDRVDPLPLDFENYK NFKEGIYYMCTHDGTKIGFVLKFAINEMETVCSEIFEETFQLDESRHELRFKSEDFDH RNNLIDQLARKMYLESSLSGVKGWRNEKYAVWVNKKPYVLVERAVAGVLGIITYGIHI NGYVLDPKSKKVQFWVPRRSKTKQTWPLMLDNIIAGGLGYPYGIYETVLKESMEEANL EKSVIEDNIKATGSVSYLYFTGDISVTKFNKESDFIVGEVQYVYDLKLSEDIIPKPND GEVESFNLFSLQETINALRKKEFKPNCALVMVDFLIRHGYITPENEPNYLELVTRMHR RLPFPTLN" gene complement(698326..700614) /gene="PMT4" /locus_tag="YJR143C" mRNA complement(698326..700614) /gene="PMT4" /locus_tag="YJR143C" /product="dolichyl-phosphate-mannose-protein mannosyltransferase" CDS complement(698326..700614) /gene="PMT4" /locus_tag="YJR143C" /EC_number="2.4.1.109" /experiment="EXISTENCE:direct assay:GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity [PMID:21956107]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:1900101 regulation of endoplasmic reticulum unfolded protein response [PMID:21231968]" /experiment="EXISTENCE:mutant phenotype:GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity [PMID:8585318|PMID:21956107]" /experiment="EXISTENCE:mutant phenotype:GO:0006493 protein O-linked glycosylation [PMID:8585318]" /experiment="EXISTENCE:mutant phenotype:GO:0035269 protein O-linked mannosylation [PMID:21231968|PMID:18182384]" /experiment="EXISTENCE:physical interaction:GO:0097586 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex [PMID:12551906]" /note="Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals" /codon_start=1 /product="dolichyl-phosphate-mannose-protein mannosyltransferase" /protein_id="DAA08928.1" /db_xref="SGD:S000003904" /translation="MSVPKKRNHGKLPPSTKDVDDPSLKYTKAAPKCEQVAEHWLLQP LPEPESRYSFWVTIVTLLAFAARFYKIWYPKEVVFDEVHFGKFASYYLERSYFFDVHP PFAKMMIAFIGWLCGYDGSFKFDEIGYSYETHPAPYIAYRSFNAILGTLTVPIMFNTL KELNFRAITCAFASLLVAIDTAHVTETRLILLDAILIISIAATMYCYVRFYKCQLRQP FTWSWYIWLHATGLSLSFVISTKYVGVMTYSAIGFAAVVNLWQLLDIKAGLSLRQFMR HFSKRLNGLVLIPFVIYLFWFWVHFTVLNTSGPGDAFMSAEFQETLKDSPLSVDSKTV NYFDIITIKHQDTDAFLHSHLARYPQRYEDGRISSAGQQVTGYTHPDFNNQWEVLPPH GSDVGKGQAVLLNQHIRLRHVATDTYLLAHDVASPFYPTNEEITTVTLEEGDGELYPE TLFAFQPLKKSDEGHVLKSKTVSFRLFHVDTSVALWTHNDELLPDWGFQQQEINGNKK VIDPSNNWVVDEIVNLDEVRKVYIPKVVKPLPFLKKWIETQKSMFEHNNKLSSEHPFA SEPYSWPGSLSGVSFWTNGDEKKQIYFIGNIIGWWFQVISLAVFVGIIVADLITRHRG YYALNKMTREKLYGPLMFFFVSWCCHYFPFFLMARQKFLHHYLPAHLIACLFSGALWE VIFSDCKSLDLEKDEDISGASYERNPKVYVKPYTVFLVCVSCAVAWFFVYFSPLVYGD VSLSPSEVVSREWFDIELNFSK" gene 700882..701691 /gene="MGM101" /locus_tag="YJR144W" /gene_synonym="MGM9" mRNA 700882..701691 /gene="MGM101" /locus_tag="YJR144W" /gene_synonym="MGM9" /product="Mgm101p" CDS 700882..701691 /gene="MGM101" /locus_tag="YJR144W" /gene_synonym="MGM9" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:22948312]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:10209025|PMID:10869431]" /experiment="EXISTENCE:genetic interaction:GO:0036297 interstrand cross-link repair [PMID:22912599]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:23536705]" /experiment="EXISTENCE:mutant phenotype:GO:0000725 recombinational repair [PMID:22027892]" /experiment="EXISTENCE:mutant phenotype:GO:0003697 single-stranded DNA binding [PMID:22948312]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:10209025]" /note="Protein with a role in mitochondrial DNA recombinational repair; also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage and mitochondrial genome maintenance" /codon_start=1 /product="Mgm101p" /protein_id="DAA08929.1" /db_xref="SGD:S000003905" /translation="MKSIFKVRGCVSHAAQFCQKRTVVSTGTSNTATAGAVRKSFNST ETKPVFATKSEAGNGSHMKEYSSGINSKLGGTPLETRSTADDSLNNSYKQVKGDIDWY TSWYGLGMKPFEAKVQKDLIEPLDPKDIEIKPDGLIYLPEIKYRRILNKAFGAGGWGL VPRSQTIVTSKLVTREYGLICHGQLISVARGEQDYFNEAGIPTATEGCKSNALMRCCK DLGVGSELWDPVFIKKFKVDHCTEKFVEHVTTKRKKKIWLRKDRQVEYPYK" gene complement(702027..703068) /gene="RPS4A" /locus_tag="YJR145C" mRNA complement(join(702027..702798,703055..703068)) /gene="RPS4A" /locus_tag="YJR145C" /product="ribosomal 40S subunit protein S4A" CDS complement(join(702027..702798,703055..703068)) /gene="RPS4A" /locus_tag="YJR145C" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /note="Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication" /codon_start=1 /product="ribosomal 40S subunit protein S4A" /protein_id="DAA08930.1" /db_xref="SGD:S000003906" /translation="MARGPKKHLKRLAAPHHWLLDKLSGCYAPRPSAGPHKLRESLPL IVFLRNRLKYALNGREVKAILMQRHVKVDGKVRTDTTYPAGFMDVITLDATNENFRLV YDVKGRFAVHRITDEEASYKLGKVKKVQLGKKGVPYVVTHDGRTIRYPDPNIKVNDTV KIDLASGKITDFIKFDAGKLVYVTGGRNLGRIGTIVHKERHDGGFDLVHIKDSLDNTF VTRLNNVFVIGEQGKPYISLPKGKGIKLSIAEERDRRRAQQGL" gene 703885..704238 /locus_tag="YJR146W" mRNA 703885..704238 /locus_tag="YJR146W" /product="hypothetical protein" CDS 703885..704238 /locus_tag="YJR146W" /note="hypothetical protein; expressed at both mRNA and protein levels; partially overlaps HMS2" /codon_start=1 /product="hypothetical protein" /protein_id="DAA35121.1" /db_xref="SGD:S000003907" /translation="MKVGKAKKKPEIFSAHCSVATAFLDPSFFYPNFVAQKASHYNDK TGSANIWTYISRTGSLLLFTQVVYRKSKWTHQSATFADCIYCQSGQSPSVSLSCSDAR QTWMQHRGWSSLMSL" gene 704196..705272 /gene="HMS2" /locus_tag="YJR147W" mRNA 704196..705272 /gene="HMS2" /locus_tag="YJR147W" /product="Hms2p" CDS 704196..705272 /gene="HMS2" /locus_tag="YJR147W" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:9832522]" /note="Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication" /codon_start=1 /product="Hms2p" /protein_id="DAA08931.1" /db_xref="SGD:S000003908" /translation="MDATSRMEQPDVFVSKLYHLLQGNAYSNIIQWSTDGSKLVIWNP DQFTKVILERFFGIHTFAAFVKQLSKYNFQKAGRPDCVEFSNIHFQKDNINSLSLVKA HQSAATPNVAAVNNMNKQCTFHWDPFKVNSILSKAIGKPSFEKLVKNVDRLQGNLDEL KSTNADSLRIIREINASLQTISYHQFHAYQTANFLQENFEAIKKVVCPDSCLQHQQRQ PKRPKRYSLLLLIPNASELSETPLMRFAGVFEFMNCSLDTATQWHPQLHPEAYDLLFV TVSPNMQQEHLIYFKRLRNLLPSFPVIAIINRPVSPQDTSIAPSNYSRYYFHHFLQLG FSDILVSPFTPTQLITLLSKHLRT" gene 705744..706874 /gene="BAT2" /locus_tag="YJR148W" /gene_synonym="ECA40" /gene_synonym="TWT2" mRNA 705744..706874 /gene="BAT2" /locus_tag="YJR148W" /gene_synonym="ECA40" /gene_synonym="TWT2" /product="branched-chain-amino-acid transaminase BAT2" CDS 705744..706874 /gene="BAT2" /locus_tag="YJR148W" /gene_synonym="ECA40" /gene_synonym="TWT2" /EC_number="2.6.1.42" /experiment="EXISTENCE:direct assay:GO:0004084 branched-chain-amino-acid transaminase activity [PMID:8798704]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:21267457|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0009082 branched-chain amino acid biosynthetic process [PMID:8798704]" /experiment="EXISTENCE:mutant phenotype:GO:0009082 branched-chain amino acid biosynthetic process [PMID:8798704]" /experiment="EXISTENCE:mutant phenotype:GO:0009083 branched-chain amino acid catabolic process [PMID:8702755]" /note="Cytosolic branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase; BAT2 has a paralog, BAT1, that arose from the whole genome duplication" /codon_start=1 /product="branched-chain-amino-acid transaminase BAT2" /protein_id="DAA08932.1" /db_xref="SGD:S000003909" /translation="MTLAPLDASKVKITTTQHASKPKPNSELVFGKSFTDHMLTAEWT AEKGWGTPEIKPYQNLSLDPSAVVFHYAFELFEGMKAYRTVDNKITMFRPDMNMKRMN KSAQRICLPTFDPEELITLIGKLIQQDKCLVPEGKGYSLYIRPTLIGTTAGLGVSTPD RALLYVICCPVGPYYKTGFKAVRLEATDYATRAWPGGCGDKKLGANYAPCVLPQLQAA SRGYQQNLWLFGPNNNITEVGTMNAFFVFKDSKTGKKELVTAPLDGTILEGVTRDSIL NLAKERLEPSEWTISERYFTIGEVTERSKNGELLEAFGSGTAAIVSPIKEIGWKGEQI NIPLLPGEQTGPLAKEVAQWINGIQYGETEHGNWSRVVTDLN" gene 707160..708374 /locus_tag="YJR149W" mRNA 707160..708374 /locus_tag="YJR149W" /product="putative nitronate monooxygenase" CDS 707160..708374 /locus_tag="YJR149W" /EC_number="1.13.12.16" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /codon_start=1 /product="putative nitronate monooxygenase" /protein_id="DAA08933.2" /db_xref="SGD:S000003910" /translation="MYFLNQLIFQDVSVMSVDKREDMSRSFQKCLNLRYPIIQAPMAG VTTIEMAAKACIAGAIASLPLSHLDFRKVNDIEKLKLMVSQFRDQVADESLEGNLNLN FFCHDIVDKPTDLQTANWAKLYRKSMNVPIDMNEIKFDNGNVSFKAFEKENALQDFFQ YLSDGFRPKIISFHFGHPSKSTIEYLQKIGILIFVTATSVREVRLLARLGINGIVCQG YEAGGHRGNFLVNDPKDDENLSTVQLVKRTVDELAEMKNKGLIHATPFVIAAGGIMDS KDISYMLSQQADAVQVGTAFLGCSESNASKNFSSPFTRETTTKMVNIISGKPARTIST PFIEKVIANFQGEELPPYGYMYSAFKQVRKKYPELANFILAGQGFQNVQSGITTDKKI ETMGARLKIDGK" gene complement(708811..709707) /gene="DAN1" /locus_tag="YJR150C" /gene_synonym="CCW13" mRNA complement(708811..709707) /gene="DAN1" /locus_tag="YJR150C" /gene_synonym="CCW13" /product="Dan1p" CDS complement(708811..709707) /gene="DAN1" /locus_tag="YJR150C" /gene_synonym="CCW13" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10322008]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:12077145]" /note="Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth" /codon_start=1 /product="Dan1p" /protein_id="DAA08934.2" /db_xref="SGD:S000003911" /translation="MSRISILAVAAALVASATAASVTTTLSPYDERVNLIELAVYVSD IGAHLSEYYAFQALHKTETYPPEIAKAVFAGGDFTTMLTGISGDEVTRMITGVPWYST RLMGAISEALANEGIATAVPASTTEASSTSTSEASSAATESSSSSESSAETSSNAAST QATVSSESSSAASTIASSAESSVASSVASSVASSASFANTTAPVSSTSSISVTPVVQN GTDSTVTKTQASTVETTITSCSNNVCSTVTKPVSSKAQSTATSVTSSASRVIDVTTNG ANKFNNGVFGAAAIAGAAALLL" rep_origin 711896..712142 /note="ARS1022; Autonomously Replicating Sequence" /db_xref="SGD:S000028458" gene complement(712255..715740) /gene="DAN4" /locus_tag="YJR151C" mRNA complement(712255..715740) /gene="DAN4" /locus_tag="YJR151C" /product="Dan4p" CDS complement(712255..715740) /gene="DAN4" /locus_tag="YJR151C" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth" /codon_start=1 /product="Dan4p" /protein_id="DAA08935.1" /db_xref="SGD:S000003912" /translation="MVNISIVAGIVALATSAAAITATTTLSPYDERVNLIELAVYVSD IRAHIFQYYSFRNHHKTETYPSEIAAAVFDYGDFTTRLTGISGDEVTRMITGVPWYST RLKPAISSALSKDGIYTAIPTSTSTTTTKSSTSTTPTTTITSTTSTTSTTPTTSTTST TPTTSTTSTTPTTSTTSTTPTTSTTSTTPTTSTTSTTPTTSTTSTTPTTSTTSTTPTT STTSTTPTTSTTPTTSTTSTTSQTSTKSTTPTTSSTSTTPTTSTTPTTSTTSTAPTTS TTSTTSTTSTISTAPTTSTTSSTFSTSSASASSVISTTATTSTTFASLTTPATSTAST DHTTSSVSTTNAFTTSATTTTTSDTYISSSSPSQVTSSAEPTTVSEVTSSVEPTRSSQ VTSSAEPTTVSEFTSSVEPTRSSQVTSSAEPTTVSEFTSSVEPTRSSQVTSSAEPTTV SEFTSSVEPTRSSQVTSSAEPTTVSEFTSSVEPTRSSQVTSSAEPTTVSEFTSSVEPI RSSQVTSSAEPTTVSEVTSSVEPIRSSQVTTTEPVSSFGSTFSEITSSAEPLSFSKAT TSAESISSNQITISSELIVSSVITSSSEIPSSIEVLTSSGISSSVEPTSLVGPSSDES ISSTESLSATSTFTSAVVSSSKAADFFTRSTVSAKSDVSGNSSTQSTTFFATPSTPLA VSSTVVTSSTDSVSPNIPFSEISSSPESSTAITSTSTSFIAERTSSLYLSSSNMSSFT LSTFTVSQSIVSSFSMEPTSSVASFASSSPLLVSSRSNCSDARSSNTISSGLFSTIEN VRNATSTFTNLSTDEIVITSCKSSCTNEDSVLTKTQVSTVETTITSCSGGICTTLMSP VTTINAKANTLTTTETSTVETTITTCPGGVCSTLTVPVTTITSEATTTATISCEDNEE DITSTETELLTLETTITSCSGGICTTLMSPVTTINAKANTLTTTETSTVETTITTCSG GVCSTLTVPVTTITSEATTTATISCEDNEEDVASTKTELLTMETTITSCSGGICTTLM SPVSSFNSKATTSNNAESTIPKAIKVSCSAGACTTLTTVDAGISMFTRTGLSITQTTV TNCSGGTCTMLTAPIATATSKVISPIPKASSATSIAHSSASYTVSINTNGAYNFDKDN IFGTAIVAVVALLLL" gene 717580..717630 /locus_tag="YJR151W-A" mRNA 717580..717630 /locus_tag="YJR151W-A" /product="hypothetical protein" CDS 717580..717630 /locus_tag="YJR151W-A" /note="hypothetical protein; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational 'guilt by association' analysis" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08936.1" /db_xref="SGD:S000028557" /translation="MLSLIFYLRFPSYIRG" gene 719666..721297 /gene="DAL5" /locus_tag="YJR152W" /gene_synonym="UREP1" mRNA 719666..721297 /gene="DAL5" /locus_tag="YJR152W" /gene_synonym="UREP1" /product="allantoate permease" CDS 719666..721297 /gene="DAL5" /locus_tag="YJR152W" /gene_synonym="UREP1" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0042938 dipeptide transport [PMID:17693598]" /experiment="EXISTENCE:genetic interaction:GO:0071916 dipeptide transmembrane transporter activity [PMID:17693598]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:3275614]" /experiment="EXISTENCE:mutant phenotype:GO:0015124 allantoate transmembrane transporter activity [PMID:3275614]" /experiment="EXISTENCE:mutant phenotype:GO:0015719 allantoate transport [PMID:3275614]" /experiment="EXISTENCE:mutant phenotype:GO:0042938 dipeptide transport [PMID:17693598|PMID:16429164]" /experiment="EXISTENCE:mutant phenotype:GO:0042939 tripeptide transport [PMID:16429164]" /experiment="EXISTENCE:mutant phenotype:GO:0071916 dipeptide transmembrane transporter activity [PMID:17693598|PMID:16429164]" /note="Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" /codon_start=1 /product="allantoate permease" /protein_id="DAA08937.1" /db_xref="SGD:S000003913" /translation="MSADASTNSNASLDEKNLNITSEAEIKNEDVTAEPVLSTVLSPN GKIVYISDKVDEAMKLAEEAKEIEVTPEEDRKLRWKIDYCMFPLMCILYAVQFMDKIS TSSAAVMGLRTDLKMHGDQYSWVTSAFYFGYLFMNLGPVQFIFQRTSHMSKMLAVFIV IWGMLLALHAAPTVKYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWF GMNGLGSILINAIAYGVYIHQDSYAIKGWRTLFVITGVITIFIGILIFLWIPDDPSKA RFLSKREKLMVVQRIRSNQQGFGNHEIKKYQIIEALKDVRTWLYFLFTVSSNIPNGGI SSFMSILLNSDFGYSSKETLLMGLPTGAVELVGCPLFGILAVYAANKKIPFWKYKLSW AIFAAVLALIASCMLGFATNSKKARLAGAYLWYISPVSFICVLSNISANSSGYSKKWT VSSINLVAYAAANLAGPQTFIAKQAPKYHGAKVAMVVCYAVMIVLLSILLIVNLRENK RRDKIAAERGFPEETENLEFSDLTDFENPNFRYTL" gene 722815..723900 /gene="PGU1" /locus_tag="YJR153W" /gene_synonym="PGL1" /gene_synonym="PSM1" mRNA 722815..723900 /gene="PGU1" /locus_tag="YJR153W" /gene_synonym="PGL1" /gene_synonym="PSM1" /product="endo-polygalacturonase" CDS 722815..723900 /gene="PGU1" /locus_tag="YJR153W" /gene_synonym="PGL1" /gene_synonym="PSM1" /EC_number="3.2.1.15" /experiment="EXISTENCE:direct assay:GO:0004650 polygalacturonase activity [PMID:10650215]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:10028181|PMID:11935221]" /experiment="EXISTENCE:direct assay:GO:0045490 pectin catabolic process [PMID:10028181]" /note="Endo-polygalacturonase; pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins" /codon_start=1 /product="endo-polygalacturonase" /protein_id="DAA08938.1" /db_xref="SGD:S000003914" /translation="MISANSLLISTLCAFAIATPLSKRDSCTLTGSSLSSLSTVKKCS SIVIKDLTVPAGQTLDLTGLSSGTTVTFEGTTTFQYKEWSGPLISISGSKISVVGASG HTIDGQGAKWWDGLGDSGKVKPKFVKLALTGTSKVTGLNIKNAPHQVFSINKCSDLTI SDITIDIRDGDSAGGHNTDGFDVGSSSNVLIQGCTVYNQDDCIAVNSGSTIKFMNNYC YNGHGISVGSVGGRSDNTVNGFWAENNHVINSDNGLRIKTVEGATGTVTNVNFISNKI SGIKSYGIVIEGDYLNSKTTGTATGGVPISNLVMKDITGSVNSTAKRVKILVKNATNW QWSGVSITGGSSYSGCSGIPSGSGASC" gene 725784..726824 /locus_tag="YJR154W" mRNA 725784..726824 /locus_tag="YJR154W" /product="hypothetical protein" CDS 725784..726824 /locus_tag="YJR154W" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /codon_start=1 /product="hypothetical protein" /protein_id="DAA08939.1" /db_xref="SGD:S000003915" /translation="MNTDSHNLSEPYNIGGQKYINMKKKEDLGVCQPGLTQKAFTVED KFDYKAIIEKMEVYGLCVVKNFIETSRCDEILKEIEPHFYRYESWQGSPFPKETTVAT RSVLHSSTVLKDVVCDRMFCDISKHFLNEENYFAAGKVINKCTSDIQLNSGIVYKVGA GASDQGYHREDIVHHTTHQACERFQYGTETMVGLGVAFTDMNKENGSTRMIVGSHLWG PHDSCGNFDKRMEFHVNVAKGDAVLFLGSLYHAASANRTSQDRVAGYFFMTKSYLKPE ENLHLGTDLRVFKGLPLEALQLLGLGISEPFCGHIDYKSPGHLISSSLFENDIEKGYY GETIRVNYGSTQ" gene 727405..728271 /gene="AAD10" /locus_tag="YJR155W" mRNA 727405..728271 /gene="AAD10" /locus_tag="YJR155W" /product="putative aryl-alcohol dehydrogenase" CDS 727405..728271 /gene="AAD10" /locus_tag="YJR155W" /note="Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" /codon_start=1 /product="putative aryl-alcohol dehydrogenase" /protein_id="DAA08940.1" /db_xref="SGD:S000003916" /translation="MASRKLRDQIVIATKFTTDYKGYDVGKGKSANFCGNHKRSLHVS VRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGKVLYLGVSDTPAWVVSA ANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKA VEERKKKGEGLRTFFGTSEQTDMEVKISEALLKVAEEHGTESVTAIAIAYVRSKAKHV FPLVGGRKIEHLKQNIEALSIKLTPEQIKYLESIVPFDVGFPTNFIGDDPAVTKKPSF LTEMSAKISFED" gene complement(728574..729596) /gene="THI11" /locus_tag="YJR156C" mRNA complement(728574..729596) /gene="THI11" /locus_tag="YJR156C" /product="4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase" CDS complement(728574..729596) /gene="THI11" /locus_tag="YJR156C" /experiment="EXISTENCE:genetic interaction:GO:0009228 thiamine biosynthetic process [PMID:12777485]" /note="Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP" /codon_start=1 /product="4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase" /protein_id="DAA08941.1" /db_xref="SGD:S000003917" /translation="MSTDKITFLLNWQPTPYHIPIFLAQTKGYFKEQGLDIAILEPTN PSDVTELIGSGKVDMGLKAMIHTLAAKARGFPVTSVASLLDEPFTGVLYLKGSGITED FQSLKGKKIGYVGEFGKIQIDELTKHYGMKPEDYTAVRCGMNVAKYIIEDKIDAGIGI ECMQQVELEEYLAKQGRPASDAKMLRIDKLACLGCCCFCTVLYICNDEFLKKNPEKVR KFLKAIKKATDYVLADPVKAWKEYIDFKPQLNNDLSYKQYQRCYAYFSSSLYNVHRDW KKVTGYGKRLAILPPDYVSNYTNEYLSWPEPEEVSDPLEAQRLMAIHQEKCRQEGTFK RLALPA" rep_origin 729983..730513 /note="ARS1023; Autonomously Replicating Sequence" /db_xref="SGD:S000028459" gene 732440..734143 /gene="HXT16" /locus_tag="YJR158W" /gene_synonym="HLT3" mRNA 732440..734143 /gene="HXT16" /locus_tag="YJR158W" /gene_synonym="HLT3" /product="hexose transporter HXT16" CDS 732440..734143 /gene="HXT16" /locus_tag="YJR158W" /gene_synonym="HLT3" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015795 sorbitol transmembrane transport [PMID:26996892]" /experiment="EXISTENCE:genetic interaction:GO:0015797 mannitol transmembrane transport [PMID:26996892]" /experiment="EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0015578 mannose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0055056 D-glucose transmembrane transporter activity [PMID:10618490]" /note="Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose" /codon_start=1 /product="hexose transporter HXT16" /protein_id="DAA08942.1" /db_xref="SGD:S000003919" /translation="MASEQSSPEINADNLNSSAADVHVQPPGEKEWSDGFYDKEVING NTPDAPKRGFLGYLIIYLLCYPVSFGGFLPGWDSGITAGFINMDNFKMNFGSYKHSTG EYYLSNVRMGLLVAMFSVGCSIGGVAFARLADTLGRRLAIVIVVLVYMVGAIIQISSN HKWYQYFVGKIIYGLGAGGCSVLCPMLLSEIAPTDLRGGLVSLYQLNMTFGIFLGYCS VYGTRKYSNTAQWRIPVGLCFLWALIIIVGMLLVPESPRYLIECERHEEACVSIAKID KVSPEDPWVLKQADEINAGVLAQRELGEASWKELFSVKTKVLQRLITGILVQTFLQLT GENYFFFYGTTIFKSVGLTDGFETSIVLGTVNFFSTIIAVMVVDKIGRRKCLLFGAAS MMACMVIFASIGVKCLYPHGQDGPSSKGAGNAMIVFTCFYIFCFATTWAPVAYIVVAE SFPSKVKSKAMSISTAFNWLWQFLIGFFTPFITGSIHFYYGYVFVGCLVAMFLYVFFF LPETIGLSLEETQLLYEEGIKPWKSASWVPPSRRGASSRETEAKKKSWKEVLKFPKSF N" gene 736044..737117 /gene="SOR1" /locus_tag="YJR159W" /gene_synonym="SDH1" mRNA 736044..737117 /gene="SOR1" /locus_tag="YJR159W" /gene_synonym="SDH1" /product="L-iditol 2-dehydrogenase SOR1" CDS 736044..737117 /gene="SOR1" /locus_tag="YJR159W" /gene_synonym="SDH1" /EC_number="1.1.1.9" /experiment="EXISTENCE:direct assay:GO:0003939 L-iditol 2-dehydrogenase (NAD+) activity [PMID:8125328]" /experiment="EXISTENCE:expression pattern:GO:0019318 hexose metabolic process [PMID:8125328]" /experiment="EXISTENCE:mutant phenotype:GO:0003939 L-iditol 2-dehydrogenase (NAD+) activity [PMID:26996892]" /note="Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor2p sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose" /codon_start=1 /product="L-iditol 2-dehydrogenase SOR1" /protein_id="DAA08943.1" /db_xref="SGD:S000003920" /translation="MSQNSNPAVVLEKVGDIAIEQRPIPTIKDPHYVKLAIKATGICG SDIHYYRSGGIGKYILKAPMVLGHESSGQVVEVGDAVTRVKVGDRVAIEPGVPSRYSD ETKEGRYNLCPHMAFAATPPIDGTLVKYYLSPEDFLVKLPEGVSYEEGACVEPLSVGV HSNKLAGVRFGTKVVVFGAGPVGLLTGAVARAFGATDVIFVDVFDNKLQRAKDFGATN TFNSSQFSTDKAQDLADGVQKLLGGNHADVVFECSGADVCIDAAVKTTKVGGTMVQVG MGKNYTNFPIAEVSGKEMKLIGCFRYSFGDYRDAVNLVATGKVNVKPLITHKFKFEDA AKAYDYNIAHGGEVVKTIIFGPE" rep_origin 737034..737275 /note="ARS1024; Autonomously Replicating Sequence" /db_xref="SGD:S000028460" gene complement(738008..739816) /gene="MPH3" /locus_tag="YJR160C" mRNA complement(738008..739816) /gene="MPH3" /locus_tag="YJR160C" /product="alpha-glucoside permease" CDS complement(738008..739816) /gene="MPH3" /locus_tag="YJR160C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008643 carbohydrate transport [PMID:12210897]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Alpha-glucoside permease; transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication" /codon_start=1 /product="alpha-glucoside permease" /protein_id="DAA08944.1" /db_xref="SGD:S000003921" /translation="MKNLSFLINRRKENTSDSNVYPGKAKSHEPSWIEMDDQTKKDGL DIVHVEFSPDTRAPSDSNKVITEIFDATEDAKEADESERGMPLATALNTYPKAAAWSL LVSTTLIMEGYDTAILGAFYALPIFQRKFGSQNDKTGEWEISASWQIGLTLCYMAGEI VGLQLTGPSVDLVGNRYTLIIALFFLAAFTFILYFCNSLGMIAVGQALCGMPWGCFQC LTVSYASEICPLALRYYLTTYSNLCWLFGQLFAAGIMKNSQKKYADSELGYKLPFALQ WILPVPLALGIFFAPESPWWLVKKGRFDEARRSLRRTLSGKGPEKEILVTLEVDKIKV TIDKEKRLTSKEGSYSDCFEDKINRRRTRITCLCWAGQATCGSILIGYSTYFYEKAGV STEMSFTFSIIQYCLGICATFLSWWASKYFGRYDLYAFGLAFQTIVFFIIGGLGCSST HGSKMGSGSLLMAVAFFYNLGIAPVVFCLVSEMPSSRLRTKTIILARNTYNVVSIICS VLILYQLNSKKWNWGAKSGFFWGVLCFCTLIWAVVDLPETAGKTFVEINELFKLGVSA RKFKSTKVDPFVVKTPPKDVSHNDPKGDIEASIAEE" gene complement(742848..743999) /gene="COS5" /locus_tag="YJR161C" mRNA complement(742848..743999) /gene="COS5" /locus_tag="YJR161C" /product="Cos5p" CDS complement(742848..743999) /gene="COS5" /locus_tag="YJR161C" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:25942624]" /experiment="EXISTENCE:mutant phenotype:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:25942624]" /note="Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins" /codon_start=1 /product="Cos5p" /protein_id="DAA08945.1" /db_xref="SGD:S000003922" /translation="MKENELKNEKSVDVLSFKQLESQKIVLPQDLFRSSFTWFCYEIY KSLAFPIWMLLWLPLSVWWKLSNNCIYPLIVSLLVLFLGPIFVLVICGLSRKRSLSKQ LIQFCKEVTENTPSSDPHDWEVVAANLNSYLYENKAWNTRYFFFNAMGCQEAFRTTLL EPFSLKKDEAAKVKSFKDSVPYIEEALGVYFREVEKQWKLFNTEKSWSPVGLEDVQLP KDIHRSKLTWFLKRIFTIYSLPLWLAFLNCICVSQHFCLAFRILCPGLFFLMMVWLFQ NMRTTALLVKMEHKMQFLLTIINEQESGANGWDEIARKMNRYLFEKKAWKNEEFFFEG IDCEWFFSHFFYRLLSAKKSMWLLPLNVELWPYIKEAQLSRNEESLMKK" rep_origin 744408..745008 /note="ARS1025; Autonomously Replicating Sequence" /db_xref="SGD:S000028461" telomere 744902..745751 /note="TEL10R; Telomeric region on the right arm of Chromosome X; composed of an X element core sequence, X element combinatorial repeats, and a short terminal stretch of telomeric repeats" /db_xref="SGD:S000028974" BASE COUNT 231169 a 142294 c 143875 g 228413 t ORIGIN 1 cccacacaca caccacaccc acacccacac acaccacacc cacacaccac acccacacca 61 actctctctc atctaccttt actcgcgctg tcacacctta cccggctttc tgaccgaaat 121 taaaaaaaat gaaaatgaaa tcctgttctt tagccctaca acacttttac atagccctaa 181 atagccctaa atagccctca tttacgtctc ctccaagccc tattgactct tacccggagt 241 ttcagctaaa agctatactt actaccttta ttttatgttt actttttata gactgtcttt 301 tcatcctact ccttcgcact tgtctctcgc tactgccgtg caacaaacac taaatcaaaa 361 cagtaaaata ctacatcaaa acgcatattc cctagaaaaa aattttctta caatatacta 421 tactacacaa tacataatca gtgactttcg taacaacaat ttccttcact ctccaacttc 481 tctgctcgaa tccctacata ataatatatc aaatctaccg tctggaacat catcgctatc 541 cagctctttg tgaaccgcta ccatcagcat gtacagtggt accctcgtgt catctgcagc 601 gagaacttca acgtttgcca aatcaagcca atgtggtaac aaccacacct ccgaaatctg 661 ctccaaaaga tactccagtt tctgccgaaa tgttttattg tagaacagcc ctatcagcat 721 cgagaggaat gccgtccaat gcggcacttt agatggggta actcccagcg caatctgatc 781 tcgcaagtgc attcctagac ttaattcata tctgctcctc aactgtcgat gatgcctgct 841 aaactgcagc ttgacgtact gcggaccctg cagtccagcg ctcgtcatgg aacgcaaacg 901 ctgaaaaact ccacctttct cgagcgcttc cacaacaacc gtatcgtctt ttgcctccca 961 ttcttcctgg cacttttttt cgtcccagtt caaaaagtac tgcagcacct ctgtcttcga 1021 ttcacgcaag ttgctccata ctttaaaata caactctttg atctgccttc cagacatgcg 1081 gaaaacttgg ctcccttgct tgcctcttgt cgaatccaat acactaattg tttctcttct 1141 tctagtaatg gccaggtacc aagcataatt tctctgtatc tgagagtaga tctctctcct 1201 ttttacgcta aaatatttca aatatcctac agggtcccca tgatatggct cgatgtcttc 1261 caagtattct ttgtattcct cgtcatttcg cagcattctc tccacagcta gtgcttccca 1321 agctatcctc cgatacgata ctttctggcc agcccaacag acacagagct cgaacatctt 1381 ttgacagccc ttgcataatc cgtattgtgt gaacactccc tctgggcaga agtatatgtc 1441 aataccatag aggaaaagat gtttaatttc gtcagaccga aatccaagaa actgtaagac 1501 attcatattc tcggaagtat tgggaaattg tgctttcagt ttctttctct ctagcaaaac 1561 catttgactc cctttccgct tatacgactc tttgttaatg tcggtgactg gatggaatct 1621 attatcctca gcattgccat ctttattggc gtcctccttg gcactagcgt tggtactttc 1681 agtggtagta gcactagtgt tggagttggt actttcggtg gtagcagcac tagtgttgga 1741 gttggtactt tcagtggtag tagcattagt gctggagttg gtactttcag tggtagtagc 1801 attagtgctg gagttggtac tttcagtggt agtagcatta gtgttggagt tggtactttc 1861 agtggtagta gcattagtgc tagagttgat acttttagtg gtagtagcac tagtcctgac 1921 gttgatgctg gcagtggtag tcgcactagt gctggagttg gtactttcag tggtagtagc 1981 actagtcctg acgttgatgc tggcagtggt agtagcacta gtgttggagt tggtactttc 2041 ggtggtagta gcattagtgc tggagttggt actttcagtg gtagtcgcat tagtgctgga 2101 gttggtactt tcagtggtag tagcactagt cctgacgttg atgctggcag tggtagtagc 2161 actagtcctg acgttggtgc tggcagtggt agtagcatta gtgctggagt tggtagtcgc 2221 attggtactg gcattggtgg tcgcattagt actggcattg gtactggcat tggtagtcgc 2281 attagtacta gcattggtag tcgcattagt cctgacgttg gtactagcag tggtaatcgc 2341 attagtactg gcgttagtac tggcattagc actaccatga atgcacgtgt tgctgtcctc 2401 atcactgctg caatactttc tgtacctgtc actgctattg ctctcctgga agctagacgg 2461 taacgcaacg atcgacatgg aagctgtcgc ctgtttttca gccaatctgt ccattctttc 2521 tatcagttcc actgtgtcag cagacaggtc tgtcctggag ccacagcatc caacatgctg 2581 gccctttttt cctttctttg attcaagtcc atagaactcg cgtacctgtt cggttataca 2641 gccttcctta attggtggta attcaccctt acgattcctt gccgcccaac tgttttttct 2701 agataataga taacagaggc ccccatctct tagtctccct acaccttgaa tgagctcaat 2761 aatattaagt ctattatcaa gcatgatcac catcatcaat tgcttaatgt caattccttc 2821 agtcactaat ttcgttccga tgagaacttg catgctaccg tcagtgacaa actcctttgt 2881 gcgagacacc ttttctgcag cacccagctt cccgtgtatc cataccaccc taaaatactt 2941 tctccaagag caggccaatt cttccacttc gttggttgtg cttgcaacta caatggcctt 3001 cgactctggt tcactttcaa agagggctaa aagaagcttc agtgcttctt cgggctgtga 3061 ttccactttc ttccgaattt tatgaacatg ccctaaaggc acctcggatt tctccttgat 3121 tagattaaac atccgtgttg gatagctgga tagacctctg ctgagatctt ccgaccgttt 3181 gagctcgttg atgtccatcg atttcttggc cagtcccgta agcccaatac gctgcaacgc 3241 agcatcagct acagcctcag gggctgtgcc gctcaaaaag attgctttct caaaagcgtc 3301 aaaatcaagg ttagttatgc ccccaaattg cgactgccgg tagacctccg tttcaaagtt 3361 gtgaaactca tctacaatga ggtaacccaa ttttacgttg ttggtcctaa aggtgcactc 3421 aacaatattc tcccacgcag ctatcctgtc tgtgaaatta gtgctagcaa gatcatcgta 3481 gatccccacg tataaatcag taacgccatc gtaaccttct tcaataaagt ttcttacagg 3541 ggccacattc aagcaaccgc gtcggcccaa cctgatcatg caattagcaa gcaacactgt 3601 gtacggtaca aacagaaacg acacatattc cacgtcgccc ttagatgcca gtgctatcaa 3661 ggggagatga aataactccg tcttaccata gcccggtggg gcctgtactg ccacagaggg 3721 tgtgtctgcc atgtatattt cataacataa gcgcaactga tgcaagtccc tgaattcaaa 3781 ggagctgcca aagagtttct ggcctgcgac gaggatatcg tttgtactct tgggctctcg 3841 gggccttttt cgcgttactc ttgaaatttt ttgatgatga tttgaactcg ccgcctcacc 3901 tgccactacg tcttccgcat tccgagtact ggagaatgaa caatggtagt cgctttcaag 3961 gcctaaccac tgaatccagc gctcggaagc tcgttcctgc aataaagtgg cggtcgtccc 4021 actgacacta gttaacgaaa aggaatccac accgtaaata tttcgccctg tttgaacgga 4081 atgattggcc atgagttcac tcgtcgccga ctcgtacaaa tctgtttcaa atctgctacc 4141 tacgcagtgc cgtcctaggg caatcaaccc ctgacgcatc tcccgaaaat tcagcttctg 4201 aggtgcattc ttcggaagtt ccctcatgta ctgccgaaaa gttgcgtatt caaccagaca 4261 gcccttcgcg gtattcagaa acatgtagga atacaaaact atcctcgaaa tgtctcgatt 4321 tgttacttga tttggatcct caaatcccac cacatccatc caaggatcat gattaaaagc 4381 gtcataactg ttaccaagcg cacatatttg catttgcctt agcacagtga caaaataaaa 4441 cacgtaatct gaggtgagtc cgtcaagcgt ctttagtcga ggctccgatg aaccgttctt 4501 gttgtaatca gtgtacagtt ggatgcgtct tgttgtatca tcgacgtata cgttgcgctg 4561 aggaccggca aaagcgagta gctgaagctc tggataacgg taagggtatc ctacggcaaa 4621 atggatcatc cacataagtg gcaccgtaag ctcgtcaatt gcaacagcga ctttattttt 4681 aagagccgcg gtcattttgt tagtatctct tctcaacttg ggcagcacaa tttcacgata 4741 tttaacaggt atcatttgaa gaaaagaatc gttttccaga tactcgtcaa ttcctcgctt 4801 cggttctctg aacaaaactt ctcgattacg caaaatgagg ttggcaatat caaccactgt 4861 aggcatataa aagcagttgt tcaactctcc ccaaaggtta tcaaactgag ccttgcatgc 4921 aaagtaaaag ccgcggacat actcgcgatt aaaaaagttt tccacatact gatataccat 4981 cagaagaagg taccaaagtt attctataag agtccttcag cgtggtttcc tgcgctactt 5041 cgtggtacag aattttgatc catttccaca ttgcaacgcc gttgttgtca tcaaatatat 5101 ctaaatccct tgcggtacaa gcacaagacg acaccaataa agctttcacg gcatctagtg 5161 tttttctgag tcttcgtgga gtgttaggac tgcgcaactt acatactttc aggccatgct 5221 cgtccacaga gggaataatg ggttcttcat tcgtaataga tcgatcctct tcgtcaccag 5281 cgccaccacg gggacccgcc ccgaaattga gtgcacatgc tcgcaagata atatgcaaaa 5341 tatcacccaa tcggtccttt ttgttcatca tatcgttaca tatctgtgaa aagtacttta 5401 tctcaatggg tttacgtggg catagatcac gcttcagccg ctctgtgtcg actttctttt 5461 cgccaggtaa acttgcttgg tatgcagaaa aaatcgatag ctcatctacg tgtagtaaca 5521 aaaacatgta gggtgccaaa ttgtacccat atttccttat ggtgcttttc tgaagactcc 5581 ttacaatagg tgcgccggaa acaaagtcag tgaaagtacg catcgtagag ctgtcgttcg 5641 gcctagcact cgctatttcg tgacaacgtt ccaggacacg gaaactcaac tcattatagt 5701 atcctctgtt gaggtaaaaa agagaaaggg tatcgtaatc ctttctattg aatttcaaag 5761 tatgcacttg aaacaacgtg tagaccatca agttgatttt cttgggaata agatactttg 5821 aagggattgg tccgccctgg aaatctggtt cgtcttcaac aaacgtcagg aactttttta 5881 catttttccc gaccatgacg gaaatgacaa ctttttcaaa agaccttttc ctatccattg 5941 caccagttct gaattttacc actttgatta ggccagactt ttcgtcttcg tagaatgacc 6001 gcacttccgt ggggatcgat tcaaataaag ttattgaggg acaatgtacc aagtcgtttt 6061 tgttatttag agccgactca aactcgtcaa agtttgcttt ttcaaactta cgcctatcgg 6121 aaactttcat tttatttttg taagtttcga aattaacaat agtatgttga ttgttatgct 6181 ttttgacaag aaatccatca atataaacaa aagattgtcc agtttccgtc ttatcatcat 6241 ctaagaatgt aataattaag ctattgagaa gatgcagaat ctgcgctatg caggtgcaaa 6301 tctctagcag cagcaaagaa aattcagtta ataagaaatc tcactaagat aagcgactgt 6361 ctgtcccctt caagcacaac atagaaaaca gaaggatgtc tcattcatcg cttgatttcc 6421 ggcctgcaaa aataaagtag tcggtacgta cgttcgtttt caatttccat ggtgcacagt 6481 atcttaacta tctgcttagt cgaggagaac caggattctg ttcgttgctc agccgcttcg 6541 tggatattct cttggatact ttaaacatgg acctacgctt agcctgcgct tagcctacaa 6601 cttcttccgc tatcgaaaag accaatataa taaaaagtta taaattacat ttccttatta 6661 ggtatacgac ctcgcgcttc gaagtaaagg agcccttttt ggcgtaccta catatggcgc 6721 gtcagacaga caaccttccc tcaaaatgta ttaccccgcc gaataagaaa acagacccat 6781 tcaccaacga cgtatcaagt tacttccttg atttgcaatg tcccactata aaaaaattcc 6841 ttaacgctag atctttgggc taaaatctgc gtcaaacagg aaatattgcc tattttcgta 6901 caaggttact tcctagatgc tatatgtccc tttacataat aaattaaaaa atttttttta 6961 taaattataa taatttcttt ttatttctaa tagtatcttg ggattaaata aatcacttac 7021 aatatttatt ttattatatt gctttgttca attaaatttt aatacgaaat tatttaattg 7081 ttttgtattt aaaatatttt gaataataaa ataatataga gttttattat aaatttttca 7141 ttgatattta ataaataaag atttccagca tacagcacat aaaatattaa ttacatatgt 7201 aattaataat aaggccatat tttgaccctg ccattaccct accatgcccc atctgttact 7261 cactatactg ttgttctacc caacatattg aaatgttaac aaatgatcgt aaataataca 7321 cacatactta ccctaccact ctaatcccac caccacatgc cacactcacc ctcacttgta 7381 tactgatatg ccatacgcac acggatgcta cagtatatac catctcaact taccctactc 7441 tcatattcca ctccactcca cggcccattc tcactaaatc agtataaatg cactcacatc 7501 attatgcacg gcacttgcct cagcggtcta taccctgtgc catttaccca taaagcccac 7561 gattatccac attttaatat ctatatctca ttcggcggcc ccaaatattg tataactgcc 7621 cttaatacat acgttatacc actttttcac catatactaa ccacttaatt tatatacact 7681 tatgccaata ttacataaaa atcaccacca aaatcaccta aacataaaaa tattctattc 7741 ttcaacaata atacataaac acattggctt gaagtatgag cactatcatg gtatcactaa 7801 cttaaaagat ccttaatatt gcaatttgct tgaacggatg ccatttcaga atatttcgta 7861 cttacacaca cctgacatta caataatatg ccacctcact gtcgtaacac tctttattca 7921 ctgagctata atacggtagt ggctcgcact catgcggggg ctatgataca attgtatcct 7981 atttccattc ccatatgcta accgcaacat cctaaaagca taactgatgc atctttaatc 8041 ttgtatgtga cactactcat acgaagagac tatatctgaa caagacgata ctgtgatagg 8101 tacgttattt aataggatct ataacgaaat gtcaaataat tttacggtaa tataacttat 8161 cagcggcgta tacttaaacg gacgttacga tattgtctca cttcatctta ccaccctcta 8221 tcttattgtt gatagaacac taacccctca gctttatttc tagttacagt tacacaaaaa 8281 actgtgccaa cccaaaaatt ttgatatttt acgtgtcaaa aaatgagggt ctctaaatga 8341 gagtctgata ccatgacttg tagctcgcac tgccctgatc tgcaatcatg ttcttagaag 8401 tggcgcatat tctatacggc ccgacgcgac gcgccaaaaa atgaaaaaag aagcagcgac 8461 tcatttttat ggaaggacaa agtgctgcga agtcatacgc ttccaatttc attgttgttt 8521 attggacata cactgttagc tttattaccg tccacgcttt ttctacaata atgtaaaagt 8581 ttctttctat gtttatcata ttcataaaat gcttcacgaa caccgtcatt gatcaaatag 8641 gtctataata ttaatataca tttatataat ctacggtatt tatatcatca aaaaaaagta 8701 gttttttatt tattttattt tgttcgttaa ttttcaatgt ctatggaagc ccgttcgtaa 8761 aattggcgtt tgtctctagt ttgcgatagt gtagataccg tccttggata gagcactgga 8821 gatggctggc tttaatctgc tggagtacca tgggacaccg gtgatcattc tggtcacttg 8881 gtctggagaa ataccagtca acatggtggt gaagtcaccg tagttgaaaa cggcttcagc 8941 aacttcgact gggtaggttt cagttgggtg tgcggcttgg aacatgtagt attgggccaa 9001 gtgagctctg atatcagaga cgtagacacc caattcaacc aagttgactc tttcgtcaga 9061 ttgagctaga gtggtggttg cggaagcagt agcagcgatg gcagcgacac cagcagcgat 9121 tgaagttaat ttgaccattg tatttgtttt gtttgttagt gctgatataa gcttaacagg 9181 aaagaaaaga ataaagacat attctcaaag gcatatagtt ggagcagctc tatttatacc 9241 cgttcctcca tctgtcatca ttacttaaac gattcgttaa cagatgctca tttagtacct 9301 cacatattct ccatatctca tctttcacac aatctcatta tcactatgaa gatgttcttg 9361 tttttgaacg aatcatacat ctttgataga cttcgtatgt ggagtattgt tttatggcac 9421 tcatgtgtat tcgtatgcgc agaatgtgag aatgccaatt ataggggtgc cgaggtgcct 9481 tgaaaaaccc ttttgcgcgc ctgcgaagtt tccattttcg gtcaaaaaga atatccgaat 9541 tttagatttg gaccctcgta cagaagccta ttgtctaagc ctaaattcag tctgctctaa 9601 acggcttcca tgcaagaaat atttctatct cttgaattcg tacaacatta aacgtgtgtt 9661 gggagtcgta tactgttagg gtctgcaaat atgtaaactc tcggcgaatg ccttggtgca 9721 attacgtaat tgtagccgct gaaggcggat ggtattgaga gaagttgata ttcaaagaat 9781 cttgtatgat aaaaataaaa ttgtaaccag ttcgtagtag cagtattaaa actttgcaca 9841 gggggaaata tttgattccg agatgtattc ccccttttct agtcagatat gaaggaaaaa 9901 agtgtaaggg caatagatgg cgctaatttg ttctattcta ttctaaaaac gttttctagg 9961 aaaaatatat taatagttga tactccttgt aatttctaag tcaaaagaaa tgtctctatc 10021 tttatcgtaa cggctcatcg ttagagctca attgtgcctc ttggatgtat ttccaaagtt 10081 ccacgtttaa taacccagcc aacacagatt cctttgagaa caaatggcta ccaaagtttc 10141 attcaaataa gcctgacaat caaccccatc aaagaggagc tctttgtttt tccaaaccca 10201 tgagaaaaaa atacagttcc ttttccatac caaaaaatga agaagaaatc atgtgctgag 10261 agttgcctgc agtcgtagaa gtttacgatc ctaacccatt atgtgattcg ttgtgagtca 10321 cccttccatg attatgtgtc cttactacct actatccaat tactacatat gttttgaact 10381 catatgtacc aagcacctaa aattacgcac ccatttccat tggcaaagac ttgacgaaat 10441 ttaatacact gcaataatat ccagcgatac tcttcaagaa ttcccgccta taatggcggc 10501 tcgctgtccg aaagattgcg ccgcacttga ctgcttctta cactcctttt tcccaggcga 10561 taaacagact aagcggaaac tacgatataa tgcagtagag gtcccccaag agctggaaag 10621 aaaatattag tttgatagcc agcactattc catccagtgg gttcttgtac cattttctgt 10681 ggtatggctt tgattcaact gcatacgtag ttaacgcgat cagccgcaca tgtccattat 10741 cattttcagg ggtactggta aaccctattg tttagaaaga atatctggta agcgggtctg 10801 tcgagtcttc acttccttca tacacatttt attgagtaaa ttatacttag atccggaatc 10861 ataacgttgg aaaaggagac aaggttggat aagttatgta ggcgtatttc aataagacgt 10921 atatgattta gtctaagaaa ccgacgtatc tagccagcat tcgcactatg acgacagttt 10981 aacgtcgtat tgagcagcat caactgaata taatgaaaaa aaaaaaatca ttccttgaaa 11041 ttcgttcttc cgaaaactgc tcaaggtgat agcacctcaa gaacaattct tcgtttgaat 11101 ttattatcaa attcatcacc gtcagagtta taagttgcac tgtattcctg gtgaccctag 11161 taacccaaaa taccattttc tgattttgca atcatattta ttggctttag cgaacatatg 11221 atcaccatac tatcttgatg gttgaccaag aagcgaacat cttcgaacca aagtcaccga 11281 atctcaagga atgcaaaatt cgtggctcag tgctctcaag acaatgttgc aaccctttgc 11341 gtcaattata tatatatata tatatatata tatatcccgt ccgctttctt ttttttgtca 11401 gttgggtcgc aacgcagggt ctcgagacct gaaaaaagct tcatagcgat attaaaggta 11461 gaggtacacc cataatggca ttgtttcgtg ccctgtatat tatttgggta ttcctactca 11521 ttccactgtc caatgcagaa gaattcaccc ccaaggttac cagaactttg tcaagatatg 11581 tattcgatat agtaaacttt gatgattcaa acactttgat cagagcagaa gaagactctg 11641 tcgagataag ttttgatgct ggagaaaatt ggaaaacaat agatgagatt gaagagccta 11701 tcgagtcatt tgttgttgat cccttccgtg ggcatgatag agcttttgct ttcgtgaaaa 11761 cggcaccaaa attttacgtc acggatgatc aaggtaaatc gtggaggcct ttgactatac 11821 ccatttctga gaaagcatcg aattattttt gcgacgtaac tactcaccct ataaaaaaga 11881 agcatcttat tattcgttgt gatttgttga caataaaaaa ctcaggctta atgtatgttg 11941 gaagagagat ttacacaact aatgatggag tatccttttc ccaagttaaa ccttcttttg 12001 gaaaaattga tggtcatatt agcacggcac gctgtgactt tattaaatct agtgaggatt 12061 ctgatctggg cggtaatgat gcttcgatac tctgtctttt ccgaaacact gagtacattg 12121 aaagtacagg ctcaactatt gacaagtctg aattgatttt aagtgccgat ggaggtgaaa 12181 cattcaaaga attagtccag ttcaaagata aggttgttag tcgatacgag atacttaagc 12241 atcatgtgat cgttttgaca caagatgata tgtataatga aatgtcatca acaaacattt 12301 ggatatccaa tgatgtatcc acttttcaag tggctcgtac acctactaag atacggcacg 12361 ttaatatggg acaaattcat gaagattcca tcggaagaat cgttttacct gtatctagag 12421 aaagagatga tgaagacagc aaccaaccgg gagctgctga agtgttaata tcagattctg 12481 aaggactaaa atttttgcct ataaattgga taccaaacaa tcagtttgga tatatcaatg 12541 tagcttatcc aggtttctta aaaggaacat tttttggttc gtttcatccc ttcattgaat 12601 attctgatag aaaaaggaaa tacagccgac agaaagtaag agaggaaact aaagtatctg 12661 ttgataacgg tctcacatgg acaaacttga aagttgttga ccgggaaaat gtagatttat 12721 ttggttgtga tgtcactaaa cccgagagat gttcgcttca gactcatttc tatgatctaa 12781 gaaatttaaa tccctctgcc ggaatcatga tgatatcggg tattgttggc gacggcagtg 12841 catacaattg gaaagaagaa aaaactttca tctccaggga tagtggttta acatggaggt 12901 tagtccataa ttccactggt ttatatacta ctggtgatct gggaaatatt atcatgtata 12961 ttccatatcg ttcgaatgaa aatggcgatg tgccttctaa attttattat tccttggatc 13021 aaggtaagac atggggtgaa tatgatctaa tcatgcctat ttatccatac agattagtca 13081 gcacaatatc agatggatct ggttcaaaat ttattctaac aggaacgtcc attacagaag 13141 atccaatatt cattacatat tcaattgatt tttcagcggt atttgattat aaatcatgtg 13201 aagagggtga ttttgaagat tggaatctag cagatggaaa atgtgttaat ggcgccaaat 13261 acaagtacag aaggaggaaa caggacgccc agtgtttggt aaaaaaagca ttcaaagatt 13321 tgagtttaga tgaaacgcct tgtaacagtt gtactggatc cgactacgaa tgttcgtttg 13381 aattcgttag agatgcgaag ggtgactgta taccagatta taatctgatt gccctttccg 13441 atatatgtga caaatcgaag ggtaaatctg tgttagtaaa gccactacaa ttaatcaaag 13501 gtgataaatg taaaacacct atgaaaattg aatccgtaga cattccgtgt gacgaaattc 13561 caaaggaggg ttcgagtgac aaggaaatag tgactactga aaacaaattc gactttgaaa 13621 ttaaatttta ccaatacttc gatacagttg ccgacgaatc tttggtcatg ctgaattcga 13681 taggagacgc ctatatatcc cacgatggtg gacaaacgat aaaaaggttt gacactgacg 13741 gcgaaaaaat tgtcgaaatc gtgtttaacc catacttcaa ttcttcagca tatttgtttg 13801 gctctaaagg taacatattc ttaacacacg atagaggata ctctttcatg atagctaaat 13861 tacctgaagc caggcaatta ggcatgccac tagattttag tgctaaagca caggatactt 13921 ttatttacta tggtggtaag aattgtgaat caattttaag tccagaatgt catgcagtgg 13981 catacctcac caaagatggg ggtgaaactt ttacagaaat gcttgataat gcaattcatt 14041 gtgagtttgc aggaacacta ttcaaatatc cgtcaaatga cgatatggtt atgtgccaag 14101 taaaggaaaa gttttcgcaa acaagaagtt tagtttcttc tactgacttt ttccaagatg 14161 atagaaaaac tgtctttgaa aacattatcg gctacttgtc tactggtggc tatatcattg 14221 ttgccgtacc tcatgaagac aatgaattga gggcgtatgt aactaatgat ggtgctgagt 14281 ttaccgaggc aaaattccca tatgatgaag atattggtaa gcaagacgca ttcactattt 14341 taggatctga ggaaggatca atatttttac atttagcaac aaacttggaa tcaggacacg 14401 atttcggaaa ccttttgaaa tccaactcga atggtacttc ttttgtcacc ttagagcatg 14461 ccgttaatag aaacacattc ggttatgtgg actttgaaaa agttcaaggt cttgaaggta 14521 ttattatcac caacatcgtt tcgaatagcg aaaaggttgg cgagaacaag gaagacgaac 14581 aattgaagac gaaaatcacc ttcaatgacg gttcagattg gaactttttg aagcctccaa 14641 agaaggattc ggaagggaaa aagtttccct gtgattctgt gtcattagat aaatgttctc 14701 tacatttgca tggttacact gaacgtaagg atatcaggga tacatattcc tctggctccg 14761 cgttaggaat gatgtttggt gtcggaaatg ttggcgatag gcttctacca tatgaggagt 14821 gttccacttt tctaaccact gatggaggag agacgtggac tgaggttaaa aaaggccccc 14881 atcaatggga gtacggtgat catggtggag tcttggtttt ggtccccgaa aacgcagaaa 14941 ctgattctat ttcttactcc accgattttg gtaaaacatg gaaagattat aaattctgtg 15001 gcgacaaagt cctcgtaaag gatataatca ccgttcccag agattctgct ttgaggtttt 15061 tgctatttgg agaagcaaaa aacatgggta gtggttcatt cagaacgtat acaattgatt 15121 ttagaaacat cttcgagagg caatgtgagt ttgatattac cggtagaaaa agggcagatt 15181 ttaagtactc tcctctgggt tccagaactg gttgtttgtt tggccataaa acagaatttt 15241 tacgtaaaac cgatgaaaaa tgttttattg ggaatattcc actttctgaa ttttcgagga 15301 acgtcaaaaa ctgtccatgt acaagacaag atttcgaatg tgactataat ttttataaag 15361 ccagtgatgg tacttgtaaa ttagtcaaag gcttaagttc ggcgaatggt gccgatatct 15421 gcaaaaagga acccgactta attgaatact atgattcctc cggctatcgg aaaattccct 15481 tatcaacctg taaaggtggg ctgaaattgg atgcacattt agcaccacat ccttgtccgg 15541 gaaaagaaaa ggcattcagg gaaaaatact ctataaacac cggcgcttat gcgctggttt 15601 ttgttacaat tcttctcgtt attttctttg tcgcatggtt tgtatacgat agaggtatca 15661 ggagaaatgg gggattttca agatttgaag aaatcagatt aggagacgat gggctgatag 15721 aaaacaatag gaccgataga gttgtcaaca tcattgtaag actaggatta tgcatttctt 15781 taatcaccaa gtctgcgttt caacgcgcga aggcaggtac agcgcaactt tcttcaaaat 15841 ttagggcaag gtttggcaac aaaaaaggtg ccacttactc ttcgctgctt catgatcagc 15901 tttcagatga accagatggc ttccatgaag attccaacga tttatccagt ttcagaggtc 15961 aaggtagtaa ttctgaaatt gagcaagaag atgttgacac atctcaacaa gagcatacgt 16021 cgcggacaga cctacttggt gctagcaata ttccagacgc tttgccagcg cgtagtgctt 16081 ctcacgagtc cgatttagca gctgcacgca gcgaagacaa gtaggtaggt ctttttaaac 16141 gaacgaaatt gttcacgcat tgtatgttgg gtttcttaca tatcaatcac tcagaagccc 16201 attttctacc tccatcaccg tacttataga attatttttc tttcttgaca caatatactg 16261 tggctagttt aacatttcgt gccctttaaa tatttttcat ggtgtggaca gaacaacgtc 16321 aattgtaagg agcatggagg tcaaataaac aatacctcaa actaaataat gaagacccca 16381 agaagccttg caatcggcag taattatatt catggtacta attgtcacta ttcgtctaca 16441 ctctagtaaa agttcttgat gcaaattttt ttatttttat gtatgagaac tgccgaaaaa 16501 aaaggtttgg atattaactt tgttaaataa aataatacaa tcaattcaaa ctttttactg 16561 tttctttttt cagctaacta tatcatacta ttgtacacaa ttattaatta ccacttacat 16621 taactgttat tcgctacgct ttagaatatc acatacccaa tatcgcatta ccacatgtat 16681 gtcgttacta tttaaagtgc ggtatgtaac atagataaat ataagtatat gtatatgtat 16741 aaaaatcttg tcgtcacaat cattaatcat tcagatatgt aaattctgcc ctcccatggc 16801 ttcaatgttc tggaagacgc atcaacttca cttcttgggt agtttccgaa ttccaactta 16861 aacgatgagc tattgtttgg aatcgtgaag tcgatcgaat cagagctgaa gttcaaagca 16921 gcaaacaatg ttttgttgtc gtatttcttt gtgaagctga acagtttctt attgtccaaa 16981 tcaataaact caaaatcata tccatacaca gtaatatcct tgtgtgcctt tctaaatctc 17041 aaggcctcct tccagaagtt caaaaccgag ttggggtcct tggattcgtc ttcagcgtta 17101 attccttccc tgaaagactc gttcaagtaa aaccatggtt tagcattagg accagaaaaa 17161 ccagcatttg gctcctcacg agaccattgc ataggtgttc tagcatggtc tctggaaata 17221 agggcaattg cttccaaaaa cctcttcatc tccttcgagt tttctccatg ctcttccttg 17281 atcgcatcat agttatttct aacttcgaca tcctcgtatt tttcgatagg ccagttcttg 17341 aaattgattt cacccagttc ctgtccttgg tacacatata gagtaccgct cagtgacacc 17401 aacaacacag acaacaactt accagaaata acacggtttt tgggagaatc gtcaccaaat 17461 ctggtaattg aacgaggttg gtcgtgattt tccagataaa ttgttgacca acaatcagtt 17521 ccgttaacgt atctgaaaag ttcagcaagg gcaaccttcc aatcctttag ttcatatggt 17581 atcaaatttt gacggaactt gggcgaagtc ccgacatcag tgtgggaaaa gttgaataac 17641 tcactaagtt cgtgtcttga cgcacttgta tacaacctct tggtctcatc agtagcatgt 17701 cgcatttcac caactgtcat aatttctctg ccatccttca ctctgtttct gatgaacttg 17761 ttcatttctt gatgaaactc atggatacgt ggtccgttca ttgtgaaagg atcactgagt 17821 tgccactttg agttttcgtc aatcacagga gcgtctggta gaccagcaac cttggagtac 17881 aagcttccca catcaattct aaagccgtct acaccatggt ctaaccagta tccaacggca 17941 ctttcgtaga ttgcctttct gcagtcttcg ttctcccagt ttagatcagg ttgggtggag 18001 caaaacaaac gcaagtaaaa ctcttgtgtc ttttcatcga acgtccatgc agaaccaccg 18061 aagtaagacc tccaattgtt tggaggaatt ggcttgcctt cggcgtcata acccttagga 18121 ggtctccaga agaaccagtc acgttttgga ttggtttttg aggatctgct ctctttgaac 18181 cattcatgtt cgctggagca atggttgatg actaagtcgg tgataaattt cataccaagc 18241 ttatgtgtct tttcgatcaa ggcaaagcag tcctcgttcg taccgtaggt tggccagacc 18301 ttttcgtagt tggcaatatc gtaacccata tcatcttgtg gcgagtcgta aaatggcgag 18361 atccaaatgg catcggtacc aagctctttg atgtactcca acttggaggc aatacccttc 18421 atatcacccc aaccatcgtt gttggagtct ttgaaacttg cgggataaat ttgataaatt 18481 gtggcctctt tccaccactt gggttctgtt tctggatgtg cagaagaaat agtcattgta 18541 cgttgctttc ttatctctat gaaaaaactt tcacttttgt ttgtgtgttt ggattggtga 18601 atggaacata tattctagta cagctaattc ctcgagtgaa gaagtcttcc ttacttatat 18661 atgtctgtgg acgtcttacg aatgatcgaa aataagaaaa gaacaaagta aatttaggat 18721 ctggaaggag tgctgtatgt aaacgaagct ttcagtttta ggtaatgttt gcacaaccta 18781 catgatataa gatggtatgt tctgcaacag cgtgcctgtc acttggcccg ttatagcaga 18841 ttataccatc tgcaagcaga ccccattatt gcattgcctc cgcagccttg cgtatacata 18901 gccctaagac aaaatacgga gcgtaaacaa ccctcgatcc ccgcaacaat tacataacca 18961 tttctccgcg gaattacata atcatttctc cgggaaaatt acataatcat ttctccgtgc 19021 gagttataag tgcttttctc gtgcatttcc ctgacacttc acaaaacctt ctttttcttt 19081 tttctttatt tcaggggaaa tcagtgcaaa actaaaaaga aagaaatttt gtgaaatgta 19141 aactccaggt gtcaaaaaat aaattatatc cgtggaaaat caggcgtcgg aaattgtaga 19201 tgaatccgcc tcctccacaa taaaaatgct gaccacacga gcaatgcata cactcggaca 19261 ccttcgttca aagtatcagt agcagttcga cacaccctat actacttagc tcttaaggtc 19321 taggctcatc tttctcagtt cctctttttc gctaaataaa ggtatataat gtcacagctg 19381 tgtaactaaa gaacactgtt gttcctatct ttttcttctt ctttttttgg tatgagttgg 19441 aaaaaataat cattgcacaa ttgagtacta aaagctttcg tatcttaccc aatatcatgt 19501 ccggtgttaa taatacatcc gcaaatgatt tatccactac cgagtctaac tctaactcag 19561 tagcaaatgc accatctgta aaaactgagc ataatgactc taaaaactcc ctcaacctgg 19621 atgccactga accacctatt gacttacctc aaaaacccct ctctgcatat accaccgtcg 19681 caatcctgtg tttgatgatt gcatttggcg gcttcatctt tggttgggat accggtacca 19741 tttctggttt tgttaacctt tctgatttca tcagaaggtt cggtcaaaaa aatgacaagg 19801 gaacctacta cttatcgaaa gtaagaatgg gtttgatcgt ctcaatattc aacattggct 19861 gcgccatagg cggaattgtc ttgtcaaaag tcggtgatat atatggtcgt cgtattggat 19921 tgattacagt tactgccatt tacgttgtag gcatcctaat ccaaataact tccataaaca 19981 agtggtacca atacttcatt ggaagaatta tttctggcct aggagtggga ggcattgctg 20041 tcctttcccc aatgttgata tctgaagttg ctcccaaaca aatcagagga accctggtcc 20101 aattgtacca gctgatgtgt acgatgggta tttttctagg atactgtacc aattacggta 20161 ccaagaacta tcacaacgcc actcaatgga gagtcggcct tggtctttgc tttgcctgga 20221 ctacattcat ggttagtgga atgatgtttg taccagaatc accacgttac ctgattgagg 20281 ttggtaaaga tgaggaagcg aaacgttcac tttcgaaatc caacaaagtc tcagtcgacg 20341 atccagcctt gttagcagaa tatgacacta taaaggcggg aatcgaactt gaaaagctgg 20401 caggtaacgc atcatggtct gaactactct ccactaaaac aaaggtcttt cagcgtgttc 20461 tcatgggagt gatgatccaa tcgctgcagc aattaaccgg tgataactac ttcttttact 20521 acggcaccac catcttcaaa tctgtcggtc taaaggactc ctttcagact tcgatcatta 20581 tcggtgtggt taattttttc tcttcattca tagcggtata caccattgag aggtttggac 20641 gccgtacgtg tctattgtgg ggtgctgctt ctatgctatg ctgctttgct gtgtttgcct 20701 ccgtcggtgt gacaaagttg tggcctcaag gaagcagtca ccaagacatt acttctcagg 20761 gcgccggtaa ctgtatgatt gtgtttacta tgttcttcat tttttcgttc gccaccactt 20821 gggcaggcgg ctgttacgtt attgtctcag agacgtttcc tcttagggtc aaatcaagag 20881 gaatggcaat cgcaacagct gcaaactgga tgtggggttt cctgattagt ttctttaccc 20941 cattcattac cggggcaatc aacttttact acggttatgt attcttaggc tgtctggttt 21001 ttgcatactt ttatgtcttt ttctttgtcc cagaaacaaa aggcctgacg ctggaggagg 21061 tgaatactat gtggctggaa ggtgtgccag catggaaatc agcctcatgg gtgccaccag 21121 aaagaagaac cgcagattac gatgctgacg ccatagacca tgacgataga ccaatctaca 21181 agaggttctt ttccagctaa tcttccggtt tttagtaact ggaaaaaaat acatgaactt 21241 aattatttat tatatacaat atttactttt ttacgcctta atccttaacg gactatttgt 21301 tatgccttat agaactagaa attatatgat aaacatgagc tacacgagtt gacagggtga 21361 acagattact atagcatctt tctctcatga ataattttta aaatgtataa attttgtaac 21421 gttccgaagg gtggagtgaa attccattca agaaaccaag cattgagaca gaacagtaca 21481 gagttcagtt gttgcggacc gagaattgta acaagtagcc ccagaaacat tcatatgacg 21541 tctgtttcaa attaagctta gtaaaagtac acatttacca taaaaaaata gtaccaagtc 21601 ggtggcctga tatccttatt ttccttctgc caattgggca agttggtact aatattttag 21661 gtgacactgc cactttattg ttatggattg aaatttctta aatgttctca caatcggcca 21721 taacgctatt tctccgacgt aacctcctgt catagtgtgc cgtgcctgaa taacttaaaa 21781 aattaaagtt ttcaatgtgc ccaaaaaaat tcacaaatag tacgcgctcg ttaaacaccc 21841 tgtgacgctg ggccaggcac tatttagcat tacttcgaaa agacgcaagt ataaagagtg 21901 agatctcacg tactacaaca agaacataga gaagcattct aataagcata taaacaaggc 21961 ttctagagaa aaatgggcgt attagaaaat atagtacctg gtgagcttta tgatgcgaac 22021 tatgatccag atcttttgaa aattagaaaa gagactaaaa taaaattgca cgaatacaac 22081 acccttagcc ccgctgatga gaataaaaag agccaggtaa taagagaatt acttggtagt 22141 tgcactgata actttataat tgaaccgccg ttttactgtg attacggaag taacatctat 22201 atcggagaca acttttacgc caatcacaat cttgttatat tggatggggc caaggtagtc 22261 atcggtgaca acgtatttat cgcccctaat gttggtattt atacggcagg tcatccaatt 22321 gacgtggaaa gacggcttca aggattagaa tatgccatgc ctgtgaccat tggagacaat 22381 gtatggattg gaggtggagt gtcaataatt cctggagtaa atataggtaa aaactccgtg 22441 attgccgccg gtagtgttgt gattcgtgac ataccagaaa atgtagtggc agcaggtaat 22501 ccttgtaagg tgataagaaa gatcactgaa aaagatagta caactacaaa ctatcgaaaa 22561 tgatggatcc actttctgga ggaattatcg aaagcaagtg ttgtcttcta tgattatgta 22621 ccgtattttc ttataagaat aaataaaaag ctagttcagt tttagtcgac taaatacgca 22681 gagagattat taattattgg tatatgttct ggtttaagtt gctcattctc aactcgactg 22741 tgtatagtag cttctttctg gtataatcta tcttcgagga gaaaattata gtttacaact 22801 tatgtaaaac tgctcaagtt ccaaccgtat agaaaacgcg tggctggtag ctttatgttc 22861 ggatttgaga aattttcggg gaaataagta ccgttctaat ttttcagcgc aaattaacat 22921 gcggagaaac tttaaactga aaatatggcc acctgcatgc gtccatatga aagggtcatc 22981 aaatagcctc gaacaaaaca agtaacattt tcgatggagt tagaaaggga tgatcctata 23041 cgcacagatt tcctaggtat ttaacctgac ctaatattaa caaaagtcca agtgacggct 23101 tctccatcaa acaagataaa ttaccaaaca caatggtcga atctaagaat actgaattat 23161 cgcaaggaac atggctcaat aagccaaaat ctgtttttca agaggcagga aaagtcactc 23221 tggaaacaga tgaaaaaact gacttttggc gtgaaacatt ttacggattt acccgtgata 23281 gcggtcattt tttgggagta gagacaggta gtgcttttac tgcacaagtc cgtgttcagg 23341 gaagctacga gagtctttat gatcaggctg gtatcatggt tcgtatagat gatggacatt 23401 ggctcaaagc tggcatagaa atttctgatg gccacgcaat gctaagcagt gttttgacaa 23461 atggaaaatc agattggtca actgctgttt atggcggaaa tgctcgcgat ttctggcttc 23521 gtgttactgt tgaaaagggc gttttgagga ttcaggtgtc ctctgataaa aaaacatggc 23581 cgttagtacg tttggctcca tttccaactt ctgaccatta ccttgttgga ccaatggctt 23641 gcacacctga gcgtggcgga ttgaaagtta ctttctcgga atggagtctc acagctcctt 23701 taggaaaagc tttacatgat ttgagttagt tcacctatat atcaatatat aaagaggggt 23761 ttgcttttgt taagaacaag gcctgcacct cactaagatc tgttgatttg gcactatgct 23821 ttttaaaatt ttgtttatac tcaatttcgt caagattttt tttactagta caatccatac 23881 agttaacaaa atactgggca ataaggcgtg catactacga aatttttagt tttgttataa 23941 taaacgactt ttagctagtg ttttaagata aagtgacgaa agttagggtg agaatagtcg 24001 aatgtattta ctaattattg aattcgtggt aattagtact tatgatgatg gggtttaaag 24061 ggctaaattt agacaataga aacagtaata atgatgtttt ctatttttct gctgtacgtt 24121 gctttttatt ttatatttct tcggaaaaag gttcagtgaa ttttctgtct tctatataca 24181 tatataaatt gcaattgaaa atagcgtaca gcgtaagtta agtatccaat gctcacatat 24241 gaaaagcaaa agtaaaaaga aatatacaag tttattattc ataaatatcg gcataactat 24301 ttgtttcgaa agatcagtac gtttatgtta aatgtgctcg ttacttcaac aagtaaagtc 24361 ttccttccca tggctgcaag gtgcgggaat caccatttga gtttgcatag ttgccaaaaa 24421 acatggtgta ggaggcctca ttatcaggaa ctgaaaagtc cgtattatcg ctactgaaat 24481 tgaaaacagc aaacattttt ttgttatctg tgtcctttgt aaacatgaat agcttgtcat 24541 tatcaagatc aatgaactga aagttatgtc cataaacaag gatatctttg tgctcctttc 24601 taacttgtaa ggcctttttc cagaaaaaga agactgagtt tttatctttt aactcagctt 24661 ctgcgttgat tccgtctcta aatgattcat tcatgtcaat ccatggtttg gcatccttcg 24721 agaaacctgc agaaggctca tcagcactcc atgggaatgg tgttctccca tgatctctag 24781 agatcaaagc taatgcttca aaaaactttt tcatcttttc agaatcttca ccataatcac 24841 gtttaatggc ggcatatgta ccagtacctt caacgcattt gatttgctca atttttctgt 24901 ttttgaagtt gggcataccc aattcttgtc cttggtagat aaaaacagta ccagtcaatg 24961 aaatgatgag agtagccaac atcttggacg aaatctcacg ccatttagga gaatctgagc 25021 caaaacgcga aacgctacga ggttgatcat gattctccaa atagatggtc gaccagcaat 25081 ctgtgttttc gataaacaga aagctttcag caagagccag cttaaagtct tttaaagtaa 25141 agggaataag ttcgtacttg cattttgggt tttcacctac tgaggtgtgc ttgaagttga 25201 acatcatatt tagttctcct tctttggcac tggtataaac tctgaagtcg tcttcattcc 25261 cgataccaac ttctccaaca gtcatgattt ctttaccctc tggaacttgc gagagcatgt 25321 agttatgcat ttctttatga tactcatgga tacgtggccc atttatgaaa aattcagttc 25381 ctttttggta aggaactgta ggatcagtga taggagcatc gggtaggccc tcaaccttag 25441 aatacatgct gcctacgtca atacgaaagc catcaacgtt gtgacgtagc caatagccca 25501 ctgaggagtc ataaatggct ttacggcact cttcattttc ccaattgaaa tcaggttggc 25561 caagagcaaa cacatgcaga aagaactcac cagttttttc gtcatatctc caagcagatc 25621 caccaaagaa agatctccaa ttgttgggag gaattggatt acctttctca tcgtaaccct 25681 ttggaggtct ccagaaaaac cagtcacgct ttggattagc cttagaagat ctactctcct 25741 tgaaccattc atgctcttca gaacagtggt tgataaccag gtcaacaata accttgatac 25801 ctctcttatg agcttcttct atcatttgga aacaatcctc attggtaccg taacgtggcc 25861 aaaccttctc atagttggca atatcgtaac ccatatcttc ttgaggagag tcataaaatg 25921 ggcacaccca tatcgcatcg acacctaatt ctttgacata gtcaagtttg gaggtaatcc 25981 cagctaaatc accccatccg tcattgttgg agtccttgaa actagcagga taaatttggt 26041 agacggtggc ttctttccac catttaggat tatggatgat cgtcatgttt ttcttttcaa 26101 tattgagcac tttctatata gtcatcaaga aacagtagtt tttcgcacca agatatgtga 26161 acaagtgtcc taatttataa ttcgtcagac gtttatgaac ttactcctca aaaccgtatc 26221 aattaccgta gcggtaatgg aagatacaat tcttaagtgt gaattacttt ttccggtgaa 26281 ttagcttcta ggattgtgac tatttcaatg gacaatgttg caaatagttt caaatattcc 26341 cgtgtttctc cgaggattct ccacggagga aaaataatgc aaagtttatt tccccgtttt 26401 cttttctccg tctaggcatt tacgctttca cgcaacttta ttatatcacc tccgcgggga 26461 ttcaacaacg aggtatgtgg agaaggagag aaattccaga gaaagcagcc tagagcatcc 26521 tgctgcagca acttataaac gtatctcaca gaaaaggccg gagaaagttc ttgaaatgtg 26581 taatttagcc tacctgccaa gcggctggaa ttatcccgag aataattccg cgaccgggcc 26641 tgttcctgaa ctctaagaag ttttggaatt tccgaacgct tcttcgcatg aaagacatga 26701 actcttaagt aaaataatat gaactggcat ggtcgtaatc ttttggacga cggaatatca 26761 tcgctaacca ttgtaaggga tgaagcttga ctagatatat ttaaacgacc atttttgttt 26821 cattcttatt ttagattgca ttttttataa gtcactttta gttagctcag aacgccagca 26881 aaaaccatga ctgatcgtaa aaccaacttg ccagaagaac cgattttcga agaggcagaa 26941 gatgatggct gcccttcgat agaaaattct tcacatctgt cagtacctac agtggaggaa 27001 aacaaggact tttccgagta taatggggaa gaggcagagg aagttgttgt tccagaaaag 27061 cctgcttcag cctatgctac tgtttctatc atgtgtttat gtatggcttt cggtggattt 27121 atgtccggtt gggacacagg tacgatttct ggtttcgtca atcagactga ttttttaaga 27181 agatttggta attatagcca ttccaagaac acttactact tatctaatgt gagaactggg 27241 ttgattgtgt ccatcttcaa tgtgggaagc gccattggct gtcttttctt gtctaaattg 27301 ggtgatattt acggccgctg catgggtttg attatagtta ttgtcgttta tatggttggt 27361 attgtcattc aaattgcctc tatagataag tggtatcagt attttattgg aagaattatc 27421 gctggtatag gtgctggttc cattagtgtt cttgccccga tgcttatttc ggaaactgcg 27481 ccaaagcata tcagaggtac gttgctagct tgttggcaat tgatggtgac tttcgcaatt 27541 ttcttgggtt attgtaccaa ttatggtacc aagacttact cgaattctgt ccagtggcgt 27601 gttccgcttg gtctatgttt tgcatgggct attattatga ttggtggtat gacgtttgtt 27661 ccggaatctc ctcggttttt ggtgcaagtc ggtaagattg agcaagctaa agcttctttt 27721 gccaagtcga acaagcttag tgttgacgat cctgctgtgg ttgcagagat tgatcttctt 27781 gttgctggtg tggaggcaga agaagcaatg ggaactgctt catggaagga attattttcg 27841 agaaagacta aagtttttca acgtttaacg atgacagtca tgattaactc tctgcagcaa 27901 ctaaccggtg acaactattt cttctactac ggtactacta tcttcaaatc tgtcggtatg 27961 aatgactctt ttgagacttc aattgtcttg ggtattgtga attttgcttc ttgcttcttt 28021 tcactttatt ctgttgataa gttgggccgt cgtagatgtc ttttacttgg agcagccacc 28081 atgacggcgt gcatggttat ttacgcctcc gttggcgtca caagactata tccgaacggt 28141 aaaagtgaac catcatctaa aggtgctggt aattgtacga ttgttttcac gtgtttttac 28201 attttctgct tttcctgcac ctggggacct gtatgttatg tgattatttc tgaaacattt 28261 ccattaaggg tgagatccaa gtgtatgtcc gttgcaacag cggccaactt attgtggggg 28321 ttcctaatcg ggtttttcac tccttttatt acttcggcaa ttaatttcta ctacggttac 28381 gttttcatgg gttgcttagc gttttcatat ttttacgtct ttttctttgt tccagaaaca 28441 aaaggtctaa ctttagaaga agttgatgag atgtggatgg acggtgtatt accttggaaa 28501 tctgaatcct gggtaccagc ttctagaagg gatggtgatt atgataacga aaaattacag 28561 catgacgaga aacccttcta caaaagaatg ttttagaccg gtgaaaacac acgcaagcaa 28621 acttcaaagt acattgataa ataatgtcca atgccctctg taatataggg gctttttaat 28681 tcctaagact gattcgatat attaaacacc agggctactg aagactgaca gtcacgttga 28741 gtcctattat atcattttac tcacagaaga tttggtaata tgatacttag atgggcttaa 28801 caacaaagtg ttttcttgat gttactgccc atgaaaaaaa gcaaatcaaa ttagtaggcg 28861 gattgttaac tttgtttatt ttgaaacccg tcaggactac caaaatataa caaagtattg 28921 attatcgtca acgctttata gatcactttt tttttttttt gaggaaccga ttaattaata 28981 catcgtagcc tctgcttatt gcataacaca acaaaaaaat acaataatac gcaacttttg 29041 tttatagaaa aataaaaatg gaacatatga tattctctgt tcgtcatatg ataacttaag 29101 cactttcgtg tgtacatagg tattctagtg cattggaatg agatcaatta tgatttccta 29161 acccagaatt tatattacta atgatttcag aattaataaa agctgaaata aaaggagtag 29221 caatgtaata ggaaataaac gagggcacat agaaaggaag aagaaaaatt acattatgtg 29281 gaattattga ttcccttggc aatttcccat agtctcatga aaattcctgg cctattctgt 29341 attcataatt ccatactctt ttttaacaat gaaactccgg taattaccac aatatttact 29401 tatatctcaa tacgaacgca tgttctcttc gaggaagacc agcattagcg ctaagcgcta 29461 agcgatgagt tgacttaatt tttaaaagga cgatgttggc gcgttagtgc ataagaaagt 29521 cagcaaatcc ctttaagctg aaaaccttga tatatttctc ggcctttaat aatggcgcaa 29581 ctgattttaa ttatctttga atggcttatc tgtaacgaac atgtgttact aaactagtag 29641 taagttagaa atactgttta tccagaatat gtaagttggt gcttctaaag taatataaga 29701 ccgctttaat ttgttgtaac ctctgaaata caggtaaccg ctgggtcatc tcctatctaa 29761 cttttggtaa aaatgacatc gaaaagaaca attttcgaaa tattcaattt gttcgggtgt 29821 cggtttaatg ctcaaggccc caatatttca taataggatt ctaagaattg cagaaaattc 29881 agctatgttt cacccatttt gttattggtg aaaaccgcca aatcgatatc gatatagtca 29941 cattttagag cgtgccgata gtctctaaac ttacacgaac gtcattattt gtaagtagac 30001 aactgggaat tttaaaaaag gttgagaaga ttcgttttat aaaatatgac gtcgtaaaag 30061 aagaaagtga caatactgtt gctgcgggtt aaaaaaataa ttctcctaca agcttgagac 30121 ctttattaca attcctacct aaattggctc ttcagggggg ttttctaggc aggtatctct 30181 agaatttact caagaagttt attttctagt gccaaaaagt ctactgctga tattcgcttc 30241 tactgattaa gagctgcttt aaaccatctt gttgcaacat tgagtttgga cttaaagcct 30301 caagttgtta gtgatgttgc ttttcaggat gacgtgtagt tgatcatctt acagaaaagg 30361 aagcaatggt acgtataaga tattatttta aatgagaagt agctggtctt caaatcacag 30421 acattgtgat ggcaaagcag tgataaataa agttttcaca cccaaagcaa catctttcca 30481 aaccgtttgt gtgccgtggt gaacagatag aagagggcac tgttattcaa attttgaggg 30541 tcgggagaat taactcgtta attattcctg gtgtcgaatt tgcgtcattc ctaaacttgg 30601 atattcttat atggcaaaaa aagaattttt tatgccacca acacgacggc atattctgga 30661 gtgattatag ccactgctaa caagataagg cggtaacacc cgattgtgca gatgtcctca 30721 tttatcctgt ttccgagcat ttgattaacc gtctctgtga gaccagttaa agacctctct 30781 caagaaaaat atgtaaattt ttttcagcca ctttatcggc actggaacga aacgatatgg 30841 tattcccagt atcagccacg gccccgtgta agccgtaaag taaacaaaaa tttttaccac 30901 taatttcgtt gcgtatcaat ttatactatt ctttgtgaaa acctacacag actaccaaca 30961 gaaatttttt tggtcaaacg agtccagtct ggttattcgc tggttcatgt aaaatgttag 31021 caccatctac agattccgaa cattaaaatc gtattatgca taatatagac attaatgagc 31081 aatctgttca ttaccccctt atcgtatggc aacagctatt cctgatgtaa tagtgatgtt 31141 atattgcttt cgccattatt aattttgagg aagctttcca aacagattac atagctaact 31201 aattgcaatt ttgcgacgcc ataaggatac gcgatttcct ccttttcttt ttcgcgttgt 31261 tctgtgcgct ctttttttca gccaaaaagg gttcctgaac aaaaagaccc tgtttttttt 31321 ctgcctgtta actctgatct taaaaagtta ccaattttct aacatttctc aataaagacc 31381 cttcgataaa caagattctt gagaaataaa aatttttgtg acgtttactt ttgaaagtcc 31441 ttgaagaatt cattactaat agagaaaaaa tggtgataat ttttttactt cacctccttt 31501 ctactatccc tcttattcgg attatctagc tttaacttcg ccagtttttt cttgacacac 31561 ttcacagatg atggtgcctt catgtcggca tgacgcatta tctccatact aaaaaatgat 31621 ccgacaatat ctccttccta tttgatcagc ctcttatcgt tcgtaaacga cgtaacttga 31681 cggagaacgg agaacttgtt gaatagagaa gagtatgtcg gtaattgatc tccgatatga 31741 gcgaatataa aagcaacata tttgctggta tgtagcgtag cttttctttc caattgacgg 31801 gacatcgaaa cagtatatta accgagataa aaatgacgac ttatcaaatc gatgtcaatg 31861 aaggaatgaa caagtccctg gccgacttgg tggcaccata gcgcccagag ccactcaaaa 31921 attactgtat aagtaacact aatttgatag atgtggtaag cggtgtcagt ctcctcggag 31981 cttacatctt catagaacag ggtgtcattt ccaaggtcga atttggttct gaaaagccgg 32041 taaccgttga tgaagttgcc tttgaaatta ttgacggcac cggtaagtat gtcactccag 32101 gtctgatcga cagtcatgtc cacattgcgt cggttgcagg agaggctgat ctgaccaagt 32161 taatgctgat gccaaagtca gttgcattac tcagaataag atacactttg gaagccgctc 32221 tggcaagagg tttcacaaca gtgagagact gtgggggtgc agaaggcttt ctgaaagcag 32281 agattcgtca gggatccttg aatggtccca gattaattac gtgtggacat gccatttccc 32341 aaactggtgg tcatggcgat ctgagatctg gtgccctacc tgctagtgcc tttgacagct 32401 gttcatgcca ctttggtcaa gttggtgttg tagcagatgg tgttcccgaa tgctacaaag 32461 cggccagaga agagtttaga agaggtgcag actttattaa gattatgggt ggtggaggtg 32521 tggcctctcc aactgacaaa atatcaaaca aacaattttg cgacgacgaa ataaaagcac 32581 ttgtagatgt cgcaaatagt taccacacat acgtaacagc acacgcctac actgcggaag 32641 cgatacaaaa ttgtatcaag ttaggtgtta agggtatcga acacggaaac ttattagatg 32701 aacgtaccgc agagcttatg gcagaattgg gttgctactt gactccaaca ctagttacct 32761 acaaagtgat gggttctgat caatttagtg cattcttggg acctgaaaat agtagaaaaa 32821 atacagaggt gctttacaaa ggaattgatg caatgaaaat tgcccagaaa aaaaaagtta 32881 aaatttgttt tggttcagat ttattgggtc ctctatatgg ttatcaaacg caagagtttc 32941 gtattagagg gaaagttcaa acgacacaag agattttgct ctcagcaact gttactcctg 33001 ccgaaatgaa cggattaggc gataaattgg gacagattaa gccagggttc attgctgacc 33061 tactgatgat gaaatcaaat ccgttggacg atataacgat tttggatgaa cccgagagca 33121 acatactatt tgtcatgaaa gagggaagga tatattgatg tagttatagt tgttttcaca 33181 gtcagcatta tttctgaatg ctagaagcct tttttttttt gaagtcataa taaaatattt 33241 ggcttgtaaa tttaagtatt gaagtcaaaa tatcctactt atatcacagt gaaatgtgag 33301 gtggatatgg ccctttaggg cccttaattt tacaagttac agaatctttt ttttttttat 33361 agcatttgta aggtccgtgt attcagaaaa aaatccaagc ttaaaaaagt gtatataaca 33421 tttggtatct gaaatacgga tctatcataa aatagaacac ctcaaggagg tataaatttt 33481 aaaagttttt ttattgtatg ctcgtgcccg ttttttctta aagtcggaat ttgttatcga 33541 acacttggca tgcgctaaag atcgttaatt tacaaaaata aggcggatga gatgcctccg 33601 ctaaatattg caggggtcgc tttgaatgtt tcgaccaaaa tgtgctctaa aatatagaaa 33661 tatcattatt aacagtataa ttaaacgttg agataaagta tttcaagtta agcaatatga 33721 aaggatgaca gaaaagaaaa taatttctta atattacaga atatgaacta aagtttgcta 33781 ttacgtgtgc caaattttga attaaaactt gatatgaacc tctgcaggtt tattattatg 33841 ttttcatgat taccaccatt tatcataacc aaatgtctca cctttcttta aggtataaaa 33901 ttttttataa tcattatcat acgttctttt ccaaacgttg tttccccacc agctgagctt 33961 accacctggg tactgtacac acaagaagat gatgacgacg gagattgcca cacctgcttc 34021 aacaccggcc cccatgacga aattgtactt attgaaccaa gctctccatc tttttcttat 34081 caagtttagg cagaatgaca ttgcaaaaaa taatgagtag ttataaggtg tgcttggtgg 34141 aatattacct gggcctgtga aaaatacagg agtatgaatg tgcttagcaa atttaaattt 34201 agggaatttc cattgaacag cataaacggc tagtgggaat agcaaaccaa tcaagaagaa 34261 ccacatcagc ggattataaa tgcgccctga tgagaaaaga tactttggca aagaccagat 34321 aatggaagca ttgaaaaccg tgcgaccatt agcacaagtg aagccatttg gttgatcggt 34381 ggtacataag ccatcgatat tatgcatcat ccattcctgg acaccaacgt taaccatgcc 34441 tgatatgata gtggcataga tttgaacggc aaagatcaaa cgaggggaaa ccttcatgta 34501 catggctaat ttcaaatctc tactcaaatt caagccttgt ctcatgacaa taaatccgta 34561 tagcttgaat aataagtttg ccattggtct taaaggcagc atataaccgc agatcaattc 34621 tgtgataata ttcaaaccta cgtgttggtt agtcattgct tccaagatac cttgcgggat 34681 gaaatttaca agggaaatta atattgcaat aacaaatgcc caagctggga acttagtatc 34741 gaaacagcac actgctacaa atcctaaacc gatcatgaca atctgcaaaa gtaaatacca 34801 ccaatcggga caatccttat agttcttgga gtagattctc atgtgaatgt cagtgccacc 34861 atttttacgg tctttaaact tggcgacaat atctttaccg tggtataaga tgcagtggac 34921 aaaaacggcg ataacagcgg caaaatttaa agcatacgac aaaagatagg aaaatggaac 34981 gaataccggt gagtattcct tatatttctc aagattaatg gaataatcct cgttaagaat 35041 ctttgttacg ttgtatttgt tttgagtgtt gtcataagta gaacctgaaa tgacgggcat 35101 gtatttggca taccaggtat tcgtaaaata aagacatggc agcactatga cgaagaatat 35161 caacactgat gcataggtgt tggcggagac gtagaatggt gtggcgaaaa cagagccgga 35221 catggcttgg gaaacctggg tgtagtcaaa tgtaattggc aacgcaccga gaccactttg 35281 agtaccaaag attgtgttag cgatgaaatt gtgtcttgtc ttcgaccccc ataggataac 35341 gttgaaatag gacagaccgg taaagaggaa tccaggtacc caataccaga tgaacgatcc 35401 gataaggacg attaagaaga acctgtaacg gggcatcgtc caaccatttg cgactgtctt 35461 ttcaactttt ctcgagtgca acgaatcaaa caaggacact gaaattaaag tctgaggcca 35521 gatagagctt gcagggttga cgacccatct tctggtaaga cctgcagcac cataaccaat 35581 catttgagat gtccaaacca acaagaactg atatccgaca ttaagtttca tgttgtaaaa 35641 gcttccctgg gcgttcaaaa tgtacatagc gtatgcagta gaggaagtaa gcgccacggc 35701 aattgtgacc acggcgtgtt cctttttggt aaatgggccc gggtttaaat cgaaaaatgg 35761 cactttagaa cacttccagt cgggcaagag agccagtatc ctaccaattg ggtagcaaac 35821 aacttgtgca acaaggaagt tgatctctag cgatggatat ctcagggaaa aaaattgatt 35881 aacaccggcg aaaactacca caaacaccgt ggtcaagaac cacgttctcc agtggttgag 35941 gcggatggtg gggtcatcct cgatggacac cgccgatctc acttcaggat atggagaatt 36001 gggcaagtat gtagggtcgc ccttccaaac gagaccttcc tcctgtatgg aatgcctgtc 36061 gaatttttgg ctttccggat cgcggtcctc ctcatcagta gtcgcagtga gattattgac 36121 gtcctcgtca atattcttaa cgaaagcatc tttcttttcc tcttccatat tgatctggat 36181 aggaatggtt gttggcgttg gcgagggctc cgactccaac gagtcgctct ccctataaat 36241 ggtactcatg tgttctgtga cgttatataa ttgttgcggt tattttctgc cacacagtcg 36301 aaaacttttt accaagaata cacagcttcc gatgattgtc catatatagt cgaaacaatt 36361 cattgaatag cccaaaattt gaaaaaaaaa gaaaaatgat gggcacccca tgatgataag 36421 agctctcttt cttcaacaac gattgctaag gcgtttacag acccatcgac tgcccttgca 36481 gtgggtttga tgtgattaac aggcagcagc aacaagcaac tgctgaaaac cttggtgcct 36541 tgcagacggc tattgtcctg gattttgtgt gacaaaacgt agatgtggcg tcttgtagtc 36601 ggaggtgtgg cgggccggaa aaatagtgga aaaaaagaaa attaatgcga tagcgacggg 36661 caggtaggga ggtttgaggg gtccgtagta tgcgtctatc gttgcaacaa gggtgactaa 36721 tgccatgtct tggcctttga tgcaacgtct cggaagttag tatcgatccg aggagtggaa 36781 cggatgcgat ttcccctcca ttctatcgat aaggttgctg ggaaacgcat tataagggat 36841 gagtgaagac ggagggaaag cataacgagg agagattgcc gagataactg agaagacgta 36901 atctaaaggc aacgcagcat gtctcgagtt gcacagctcg actcgatagc gcttgataaa 36961 gaattgtatg gacagttttg gtccgagttc aatgcagcat tcaatacgag tgaacacaaa 37021 gaggaatggg agttggcact gaacacagtt gtgtttatgt gcgcgacgag gttcctgcca 37081 cactatggct ctagctgtac gtatggatcc gcactcagtg gcgtggtttt tcagtgcagg 37141 aaacgcacct tgtatgtcgt cactgtcttg gcagggtacg tgtggaagaa gatcacacat 37201 attattttta atgggccgca ctgtgggaac cagatgatgt ggctgaagct gtacaaatgg 37261 gttaatttat tgtatcacgg ctgtgatgta accaacttcc tgaggtttct agcagcggaa 37321 gggcccaatg cgagggcgtt tttgtcgccg ttataccggg cttttaatgt ccattccaca 37381 aggttgattc gggatggttc tgcaattgcc tctgaatttt attcgaactc tgtattcgct 37441 gggttagaat accagaatag acaattgcta tggaatgcac tattagaact cttttccaat 37501 acactactta cgaaaagagg actcttgacc tttgttaaaa aaccaccaag gtctcgttct 37561 acgactactt ataagacagt ttgcccccgt tgcggcggtt ttccaaccaa cccataccag 37621 atcgcttgtt gtcgtgcgaa ctactgttac gtgtgcgttg taaaggcgtt ggagtggtct 37681 atgtgcgatg cctgtggatc ctctgggaga ctgaccgcct caccagtgta ctaaagggcc 37741 ccgttccctc gcttgtatct ctatatatgt gtatactata ttcatattca tgttgtcaaa 37801 atcggtcacg tggtaaaggg tctggttttt tttttttcac tttctgctca agaaaaaaaa 37861 gaaacaataa agaagtggta taatatcatc atggaacgct gtacgggacg atgtgggaag 37921 cgacgtctga aatccagtaa taataaacag tgagcacttt aggatagcag tagtttgcat 37981 tttgcacgtt tccctttcca tgcaatgttt ttacctcgtc tcgttcggta caggaccgag 38041 aggtttataa aaatggtacc taccaggacc ttgcgacgaa tcaaccacag cagcagggat 38101 ccaattcaaa aacaggtctt ggcccttatc aaagcaaatg cgaatttaaa tgacaatgac 38161 aagttgaaaa tacggaaata ttggtctgac atggcggact acaaaagtct tcggaaacaa 38221 gaaaatagct tactggaaag ctctatatta cacgaggtca agatcgaaga tttcatcagt 38281 ttcatcaatc gcacaaaaac ctcatctatg actacaagag gaatttatag aagagaatgt 38341 ttgtaccaat gcaagaaaaa cttggatcta gtcaatcaag tggtctccca agtttcatcc 38401 gtaagacatc aaaagccctt gactacgcaa ttggatacta tgcgctggtg tgttgatgat 38461 gccatcggca caggagacat agttatggct gccgaccttt tcctgctgta ctacagatta 38521 tttacagatg ataaaaagct agacgaacaa tatgctaaga aaataatatc agtattagcg 38581 tacccaaacc cactgcatga tcatgttcat ctagtcaaat atttacaact gaactctctg 38641 ttcgaaagta taaccggagg cggaataaag ttaacgaggt ttcaattaga aactctttct 38701 aataaggccc tcggcttaag taatgaagcc ccgcaattat gcaaggctat actgaacaaa 38761 ctgatgaata taaactattc tttgactaac gatttgaagc ttcgggatga tcaagtgctg 38821 cttgcgtaca agtccattga tgaaaattat agaagaggaa atgttgcaag tgtgtattct 38881 atttggaaca aaatcaaaga gcactatgtt tccatttctg cacatgattc cagaatcatt 38941 tataaagtct tcaagatttg tacccataat agagcctata gatctatatg tagcgaaatg 39001 ttttggcaat taactccaga gtactattgt aataaccctt tgatattacc ggcaattatt 39061 gacttcatta caaagcaaga ctctttaaca atggccaagg aactcatgca gaacattaac 39121 agatacactt tacccgaaaa ccatcatatt gtctggctta acaagagatg tctttcttca 39181 ttgctaagaa tgcatttgaa atttaacgat tctaacggtg tagatagggt tttgaagcaa 39241 ataacaacaa atttcagggc gctttcgcaa gaaaattatc aagcaataat tattcacctt 39301 ttcaaaacac aaaacctcga tcatatcgct aaggcagtca aattactcga tactataccc 39361 cccggacaag caatgttagc ctatgggtca ataattaacg aagtagttga ttggaaattg 39421 gcttcaaagg tcaagttcac cgataatttg atggcacttg taaacgattt gttgacgaag 39481 gcacatgatt ttgatcctga ccacagaaac tctctttgga atgtggtttc cgctttatac 39541 attaaaaaac tttgtcatta taaaaagcga gatggtaaat ttgttgccaa tgccaagaag 39601 gatatcgatt tggcaaaact actttatata aatgctgcaa agagaagtaa aacatactgg 39661 acaaaatcga actgtaaccc attcattgca tcctccccat gtgatgtcaa attaaaagtg 39721 aataatcaaa acaggtttac tattttaagg aatattgcat taagcgcact gcagatagga 39781 agaacagaca tttttctttg ggcgtgcgca gaactatacc agaacggtat gacgattgag 39841 gaattgaagt tagactggaa tttcatctta aaacatcaaa ttagaaattc agagttcaaa 39901 acaaacaagg agatcataca agatattaaa aagcatggtg tgtcggctgt caaacgttac 39961 ttaagatgaa cggccaaacg cacatttacg atataaataa caaagcaaat aataacaaaa 40021 caaatttctg taaatatata ctaaatccaa gcattgcatc ctaattcttt tctttttttg 40081 atcatcaaat aaatgtatta ttttatgtta tatgcgttag acttgttata ttctttcatg 40141 ctattctatc gttgtgttat gaattaattt atatttacag tttttcagta cattcaattc 40201 cttttttttg gaggaggtaa caatttcaca tctttcgatt gtttgatcgc cgcgttagag 40261 aaatctctca ctacaatttg acaatttacc tctttgcata atgccttctt ctttgaaggt 40321 ggtacttttt gcagaagttc tagcccagta cttctctcta aagcatctat aggaacttca 40381 aagtcagtca atttcgtctc atttgatatc ggttcgtttg gcaatacaaa tgccgcgaca 40441 gcaatatcct ctctagcagg attggctgtt ggtgcttctg caacaatcaa tttaaaaaag 40501 tgcgttggaa cagcaatact gggtggattg ccaataactt cataattaac cctaaattta 40561 ttatctatgg gatccttttt gggtagatac aatggaccag tcacgattct tacactctta 40621 tatttcttag tcaatcccct acaaaagtac tccaaatgcg cccaatagtc tctattaaaa 40681 ccttctccta cttgaggaca catattggat aagtagaatg tatcatccat ggcctgttga 40741 gaaaattttg cgtctgcagc tggggcttga tggcctcgat catagcccga cctaaaatag 40801 tctcttagtt tacctctaaa cttttctgga attacttcat cttccttgaa aaaggaattt 40861 tttctgtcag cattccttgc agccaatgat tctggcgtta tatgttcgag gacccaataa 40921 ggattttgag tttgtctgtt gtaacatgag ataaactctt cgcggttctg cagatcatga 40981 atcggaccag gaaaaccata cttgaagaac ccggaaggat cgacgttgaa agagtgagat 41041 tgaatattac tattaggttt ctgggtaggt ggataaggtg tctcaatgat ttgcgttgga 41101 gaatgtttgt tcaaaagaag ataggttaag ccagtaccag cacccagtcc gactaaaccg 41161 gacaagagta tcctactgca catgataact ttaactttgg gatctaataa gtggggaact 41221 taactaaatg ttcttatctt tatacaattg taactctata aaaactaaca aattacttga 41281 tgagtgacca ataaccaatt gcaccattga tattttttca cagattttat tttttttttc 41341 ttttttcgcg atgagtttta tttccgtgca tatgcatccg acttgcaatt agtcgaaaga 41401 tttcagttga aaggcctctt cgacagagcc caaagactgc gatttaacgt atgcctccat 41461 cacggaacct ataattgctt tttgttgagg acttatagtg ctagaaatgg cttctttaaa 41521 tgaatttttg tccaatttag ccaaagcaac tatgccactt gctacttcgt tgtctatttt 41581 ctctgtatat gcgctatgat atgcggcaaa gaaagaaaga cataaagcaa ttgacaatga 41641 tgccttttgg tgatcttgtt tgattacttc ctcggaaaac tgaattatca acttagtttt 41701 aatgcttgcc tgcgataagg aatcgtttgt ttgaatatct tgaaagaatc tttttataac 41761 caacttcata aaatactgca acaacgggta tttgaaaata ttagatatta ttctcttgaa 41821 gccttgtaga gcaattggct gcgtagcagg attattcaat gcctccgaga gaatatttgc 41881 gcactgattc agttcctgaa aacttagctt agagtatcca ttagacagca agatcaaaat 41941 ggttgcaact ttattctttg aatccagctt atgataaata acatctttta ttgacccgta 42001 gaatatttct agtaacacaa tatttttttc gtcctcagat tccgtaagcg cttttactag 42061 tgccttgaaa agtgggagta tgattggaat tattacttca cgatgactac attcataaat 42121 tttccctatg atgaataaaa gacatgaata aagatctact ttgaacatat tgtcgaagtt 42181 actgatattt gattcgaacg caataaatgt ttttttcaac agactaatat ctgtgggaga 42241 gatttttatt tcattatcat cttcttcgct ggtaagcacg ttatacttaa taaatggcaa 42301 cctctcagaa ataattgtca tcagtagtcg cagtagctca tatagtttgt caatatcttg 42361 tagaaatgtt tcaggagtag cattacactt cgaataccca atgatcaagt cactgatgat 42421 atcaacaagc aaaaattctt ctttactgtc gcctgtagaa atcagtctgt ccataatctc 42481 aacaacttca gtaataatat catcctcaaa tatacttttt atgcacagat tgctcttcaa 42541 aacattgtgt aaagccggta aaacttgcat cttgactgaa tgatcatcaa tatttttgac 42601 gatagcctcc aaacattggc taaataaaat aaaaagaaaa tactctaatt cctcatcgtt 42661 aagagatgcc aaaatgactt gaacgtctga atccagagtg cacccaaggg cctctacgaa 42721 atttaaccag accggttcat ataactcaat tttcgtactt cttggttcaa tgagactatt 42781 ttctttcgag tcattcttta cttgcacagt agaatcatta tcgttatact ttatcatcat 42841 gtattcacgt aaagaaatga tccataatgg gactaaaatg ctccaatatt tcctggtaaa 42901 agagaaaagc gcatcatttg acgacgtgat ggatctttgc actacctcag cccacgcatc 42961 caaaacggca agttcaattt ttcttttcgc tttgggtgta acgattatag cttcccctat 43021 ccgtataccg gaattaggat ctttaaagtt accaagaagg tcaattagta attgtgaaat 43081 tcttcccaat ttatctggtg gcattatatt cgatgccaac acttcagcag caacagtaat 43141 agcaaaggac attacagtag gtgagcttcc tttactaaaa gcaggcatta atgcgctagt 43201 tatttgggcc tcttgctgtt ctaaaatcga cgatccagga acctgaggat ctctcatggt 43261 ggagtagttc ttgagaacaa aattcaaaat gtgtagtccc gttaacttca tgccttcatt 43321 cctcactgta gatccacgaa atgatatttt aatgagatct gcaattttgt tgctgagggc 43381 aaggagcaga ttttcatatt tttcggattc taagcacaac attaatatta aatttaagat 43441 aatctgtctg ctcttccatt gcaggttctc agagtcgaga ccaccagcat ctgtgtcagt 43501 cagttggtta acattcgcta ttgattcttc ttcttcgcct ttaatttcct tttctgaaga 43561 tttttttagg ccatttacct ctagtagggc tgaaacgtct ctgttatagc tttggaagag 43621 tcttcctaaa ctcatattaa atattgagta taatttatcg aaccaatgat tatctctttt 43681 gaaagtatgt aatatccatt cggtaaaata attcttgaca gaaccggaat ttggaaaaag 43741 tgcgagatat ctccagctca aattttccat ttctttcatg aaaaattcct ccatctgtaa 43801 tttgtacaac aacgtcaata aatcaaagtt ttcaaaggcg cctttcagac ttgaagttcg 43861 agaaatgagt tcatttgagc ccgtgaatgt agtgtcaaaa tatgatgagc ctattccagt 43921 cactattgaa cttttaatta tgctcttaga agcaagaata aagatttcat agtttagaat 43981 gtttttcatt ttaaaagtag ctatgttttc aaacatttta atgctggtta tgctgttgag 44041 aatattattt gaaattaaca tggagagtgt aatgtttctg aacgaatcaa gaaccttggt 44101 gttaagttct agaaaatttg gccccacagt ttcagtcaat gtccttgaaa tttcaccgat 44161 tgctacgtga gaattaaagt ccctattata gttacagcga agagtagagc gtccgtaaat 44221 accatactta tcctggacca aaagctcttc catagaactt agcaacagag ctgccgtctt 44281 taaatcaatc actaaatgtt tctcaagaag aatatgcatt gctttcaatg accatgaatg 44341 aacaacaggg tgtggatccc tcattaatgc aaaaattaca tcaaagtatt cttcaaaatt 44401 agcatattgt gagttatatt taaaaattgt agccaatgat aagacatgaa acatccttaa 44461 gtatggttcg tccatatctg cgacgttttt aatgaatatt cttgattgct ctgtaaggaa 44521 tttttgtctt tcttcatcgc caagtgttct tgcgatagcc gctgtcagca atcctacaca 44581 atctgccttg atttttgtga gaaaaatgtc attaaaaaac tgaatcttct ttattgattc 44641 gataattagc tgccccactg aatagtccaa ctctagattg ttttcttgca tgatgcgtaa 44701 agcattatgc agagcactac aaacattagc agccacagcc acgcttctca atggtgtagt 44761 cattttggag aacatggaca aatttaaagt ttccataatg gaatactgta ttttgctatt 44821 caaaaaaggg aatacagatg aaaaaagttc catagaagag tcgattaaag atgtagtgac 44881 ctgaggtgcg tagcggtcaa tttgggaata agacccagat ccatatagta gaatcagtga 44941 atctaaagat aaaatgggtg aaattggttt tgatacttct acttcgaaaa tattgtacca 45001 attgtaatcc ttggatggcc aacttccact tattgattca tcatacttgt aagcactgga 45061 catcgataaa ttcacgatac ggtccccagt tattttgctg gataggccga atgcaaagcc 45121 gttgttttga cgaagtaaag tattaattga agattctaat actatattac tttccatgtc 45181 gtccttgtta ctcactttcc tgttaccaat atctttcaag cttcccaaaa cggaactact 45241 tgactcggtg taaagattgg gatctgaaaa attcttcacg attaatatta gtaaagaact 45301 attaaaatcg ctatttatgt atttctccag cttaaggtat acctgtaaaa ttctgttttc 45361 attatgcagt aaagcattgt caatgttttt cgatttcagg tcaatggaat gattaaaatt 45421 ggagcactta gttagcaaat atgatacttg tttagccatt tctttatcaa ttgtcgtatt 45481 gcttaaatac gtcaataaac aagtcaatgc atgatttcgg atttctaggt tcttgtataa 45541 ttcatcctcg tcgtggtatg tgtaggtatg tgttaataaa actttccaga aaagaaatag 45601 ttggggtatc tgcagcttca aatactgttc atctttataa ttcatcaatc ctatcaataa 45661 tatccagcat aaaagaccct tgaagtacaa attagaagag gtagatgtag tattattctt 45721 aatgaatgat gtagaaaaca ctgtaattct catgatcaac tcataggaaa tataatcgct 45781 ctcggcacct ttgattagat ttgctattat aaaagcatgg ccatgatttt tatgaaaaat 45841 aaattttcct gtagatttaa aatcagtgga tagtgcacgt aaggagtttt caatggtctc 45901 cgaaagatat tctggacagt tgttcaaaaa aaccttcaaa atttccacag tgtgaactcg 45961 tatcgtaaag atttcacatg tagctaaatc aaccagttta tctctaatct ctttaacggt 46021 attttcctca gtggtgaaag tagaacctaa gtcgctgatt aacacatacg tgaagtcaag 46081 ctgcagtaat gtaagccact gtgtttcagg cttcgcatca atactatatt tgaaatttga 46141 agctgaatca cttttagagg agctctggta agtatcagaa caacctagga tgtagtacaa 46201 catttgagtc tttgcagaat cattcaaatg tggcaatatt acttcatgca tatgttgaaa 46261 gtatctcaaa taccttgata atgtattcat gctcctatta ttcacttcgt aactgctgaa 46321 gacgccgctt aaagagagaa ctatatccaa atattttgag ttactcaaaa aagtgttgtc 46381 agctaataaa ttcaagttta tcaaatgaat aatagattcg aagcaaccac tttccacgtc 46441 tcgtgtatca cagtttaaga atatcttaac gtagatggac catacttctt gtagagttaa 46501 aatattttta gaaaagtaat aatcaaataa tatctccgct aaagattttg cggtaaagat 46561 acgagtttcg tcgtttgcaa aaccataaac acctatttca ccttcggtaa atctagaata 46621 tatggtctct ataatatcat gggagtgctc tctgataaaa ttagtttgtt tgaaatgagc 46681 tgtccagcat tcaattagga cagacacaaa agtaactgaa aagtccttct catcagtgga 46741 aatactgtca aaaacggttt tggatagttt cgaaaatttc gcatatgtgg ctggatcaag 46801 gattttatca tcattattgg aatttcttag aatcgcatta aaaagctgaa gaagggttgt 46861 catgaaggta gcatgataat atttactttt ctccataatt tttttcaggt ttttgaaaat 46921 agcattaaat aacaatggga ttaaggaaga gatgctactt ccaaaatttt caaataattg 46981 aacaagtatg gtacatgcga tatcttttgc cggtgagtat atgtactttt ttttttttgt 47041 acttgacttc ttcttttttt tcttttggtt agggtcggta tctccatcat caatggatac 47101 atcttcttca cacaatacgt ttgttaagaa tgctgcggaa tcaaaaacta caccaggata 47161 ttcgtccttc aaacgccata tggaaatcgt atagagctga gacaaactga taaacactga 47221 atgcagttct aaatcatccg tattttctag tacggagata tacctcacaa actcatccag 47281 ttgagtgtgt atttccttaa cctcctgtat ttcattatca ttaacttctt tcaaacatat 47341 aagcttttcc aaattggtgg ttatccaagt taataaatcg tgaccattgt ttgatgatgt 47401 ttctatcact ttcttgaggg atcggtttgc cattttcgtg gcctgggcta tttattttat 47461 cttttagttt tttttaaacc taataactat tatttcaatt gaataataac aaatcactgt 47521 ttcaatatgg cgatgaaaaa aaaaacggcc acacacggta tgccactatg tggtgtgagg 47581 aagcagataa aataataata cataaaaaga aggatgtaga agaatataca gatataaaga 47641 agtcgcgagt ttaaaggttc aatttactgt tgggtcagag ctgaattctg aggaaaatat 47701 ttgattgttg gcagaagaat cttggccaat tagtgctgaa aaatcgatga catcaggtaa 47761 tactctgtta attgagtagt caaattcctc aaattctgct agaagtttat ctaagtattc 47821 ttcttgtgca gctgtcgttg tatggctctc attattggta ttctgaaact ttagatcagc 47881 ttccccttgt ggaagattca gaatggaacg aagactcgtg gctggagttt ggtgatgctg 47941 ctgtccatga tgtaattctc cttggcactt cgtaaaatta ttatttgtct gcaactgggg 48001 cactaaagct ccactacttt cttgccgttg caatttaact atattcaaaa gttgttcaga 48061 taatacagag gtcttctcgt taaactcttt gaacaattgg ttcaatactt caaaagtacg 48121 tttactcgca tttgaagcac ccttcaaaag tgataatatt tcactgccaa gctgcgtagc 48181 gttatgaata tccgaatcaa ccttcccatt tcgtatcagg cccttttctg tttggtagac 48241 ataaaatttg aggcaagcaa cactaaaaaa gattgtatga atggaaaacc agtagctacc 48301 actcaaaagg ttttgcgtaa tcatttcata agataattga ataacttttt tggcaacttc 48361 aatacagttt tccgccatgt gaatttgaaa ttggaactct gggatatcta acgggtctat 48421 agaaatatag tggtagaatg gtttatagag tacgattttg gatagaagga agtccagata 48481 taataatttc ttaggtttag tgtatggaga actagtatca tttgcggaaa cagttagagg 48541 tggttgcgtt tgacgatacc gtattgtgtc aaccttcaaa atatctggta attgggcata 48601 ccaattatct aattgatcgt tcaacgatac aatctgcgtc ctagaatcct cttctaatgg 48661 ttttcttctc aaagagtaca ttagcttgta gatccgagac atgattaaaa taagctttgt 48721 atgcttatta ttcattccac aggaacttat cgttcgccaa tcttgaaact ttattccaat 48781 agtagatata ttttcatcgt cgacgtctag aggaaactct tggtcgatat cagattcgtc 48841 gataccgctt ggaaaaccaa gaatacaatt catgtacaga tctagtttgt acacagacca 48901 aaagagcctt ttttttgtct catcctgaat cggagtagga ccaactatgg aagaccgcct 48961 gtgtaaacct tcctttaacg cagcacgcag agcgatacca atgaacgaat agcaagcctt 49021 caagtttgct gaacattgca aaaagatcgt catcataaat atagcttgaa tggaatagat 49081 gtcagtaata ttagaaaagt ccaaagagtt tttggcctct aaaaagtatc tgtagccttc 49141 atcagtgtaa aattccctag ttgctttact atccttgctg agatcttcct tagaaaaaag 49201 ggctccgact gctaaaacag aataaattaa aggttgtgtt ttcacttgtt ctggagtata 49261 ttgcttgcca tgtttttctg cttcgtatat cgagtccaag atagaaatga tagtaggtct 49321 gtgatagaac ctaaatagca cacaggcaca atcccaggtc ttttgaataa atttcaaggc 49381 aatctctctg ggtggtaatg gaacacttgt ttgcatgtgc caaggcgtat cttttggtag 49441 actttgacgt attacctgat taacatttaa ttgtccttga agtagacacg ttttaatagt 49501 gtccaaaaaa ttctggctgt taaaagaaga agaagcaagt atttgacgga gtgtttcagg 49561 tggaaagatc gtctctacaa cctttttgta atcaatggaa cttatagggc ccttgctatc 49621 ttcccgttcg tgggaagctc tctgtgcata taaggaacta tcatcgctta cttccctatc 49681 aaataccgat gagttccgtg gggggcgatc atatttgcat tcgtaactat tagtctggca 49741 aagtctacat ggtatattac cactacatcg tactttcctc tttctgcaag ctatgcaagc 49801 tcgatgtgct cttcctttcg ttggcttcaa ttcgttggtg cccgcatctc tagataaaac 49861 caaaatctta gatctcttgc ctttcaactt cttcattgca cacgaaatag gctttccaga 49921 ttctttcggc gtcatctatt gaataattct ttggtctaag ttgtatgtat tactctttaa 49981 attgagacaa tcaaggaaat cacacatata aaaatactgt ggatctgaaa gattgggttt 50041 ttataggata aatgcgtata aaggtagatc ctaggattaa ttattatggt atttacatat 50101 cgccagaaac ttatatatac tcccctcacg ccggattatt atttgcgatc gtcccatcgc 50161 ttctttatga gctcgtgtaa atgatgacct tgtggacgcc ccattttcct ttcgtacaca 50221 tagtagctga gacagcctac cataattgcc aataacggat cagaaaatct gcaatagaga 50281 ccagcttggg aaagagcaca tcgacttgtt tgatgttgcc tcttcgaaac agcaaatggt 50341 taactatgcg ttagtaaaag aataagtgtg aaaaaaaaaa aaatagaata gcgtatgaag 50401 aatgaacata ctttcctaat agaaagggag cgtactgaac catgttatcg atgatcttgt 50461 gtggaatcct cttataaatg gagtgaacat ttgtatgccc cttgtgtgcg tgtggctaac 50521 agggaaaaat agagcccgcg taatcttgaa taatctaata tgtgaacagt cttttatttc 50581 cgcacttcat acctatatag agtaatataa ttaatcattg ataggaattt acataatgca 50641 gcaatctcgt atgcctaggc cgtacattac cttttcaacg tctttccgta cacgaaccca 50701 atcgcttctc ctctgaacaa attcataaat ttcctcttgc gtaaaaatgc cattgaattt 50761 cccaagatca gaaataagct ttcccaactc tttcgagtcc ttgcctgaaa tgatgtataa 50821 ctggccaata gacttaagcc caacaaaata gggaacaaca tttttttgtt ttaatttgtt 50881 agcaataaaa tcgtaaaagt aatttaaatc gcagattaac caaattgcgc cctccgtaga 50941 tatgaagcac ttcttcagat gtttgacgat ttcattaaag aatctctcgc caatttcttg 51001 ttggtacacg tcaatagtac ccttgtctgt ggcaccagtc agtagaaagc aatgattaga 51061 aagtaactcg actaccctga tagcacattt ggttggcttt atatccctta ttggagaatt 51121 cctagagggt ggcggtggat tataatcgtc aggcaattga agagtcttga atacaaatga 51181 gatttcatcc attagtttgt ttataccgat atttaaacct tcggctacaa aatcatcgat 51241 agaagtctca aaattttttt ttaattggat aacatcatta agaaaatctt tatttttatc 51301 gataattttt ttgggaatca attcgttctt gtaaaaaatg gaaatcattt gtaatattat 51361 gtcacctata ttgataagtt cagtgaattg tactaaaggt tcgacttgag tattggctgg 51421 cgaaagtgaa ttgaatttta tttctatttg ttctatttcg ttaggattat atttttgtag 51481 tagcaggatt gccttttcaa atgcaggttt aacgtgattt ttattcaatt gtgtaattaa 51541 aattttgaaa atctcttgac agcgtagctt gatcaatggt agcaaacttt caatcgtatg 51601 aaatttgtaa atttgatccg tcttttcgct tgtttcctgt aaaattttgt aacataaatc 51661 gagacttatt aacgatttaa tgttttgcaa gttattggaa attaaattta agttgtaggc 51721 tagttgtagt tgttgcttta gcctttgatt ttcattgttc gagaacttga aaatcttggt 51781 gaaggaactt agaaagtcta gtttatcatt agaaatatca gttgaatgaa ctgattgatg 51841 gatcgtactt ggttttgaat ccgcttctgg gacagttttg gaggtttcag taattattga 51901 gaggtcattc ggcaattcat tgttacttgc actcgaagca tccgtttgat cttttaaagt 51961 gttataaatt tttgcgtttt gctcacgctg cttgtcttga acttgtgtgt cataattagc 52021 taattgtgag ttgatcaatg attcaaatac tctagttgtc tgattcatat agttgacaac 52081 aaagggctcg agatacaggt ttaaaaggtc acgaacaact ttacggaaat ttgcgcctgc 52141 gtttactgag tcgtttaatt cagtatcaaa cttttttata aatgtgaaat aaagttcggg 52201 tacgcattca taattggctt tactatcctt tccattttct tttaaaaatt cactatagct 52261 taataagata ttgtttaaaa tatctaataa aatatcttgg ataaaggact cgatgaactg 52321 taatattaca gggaactcat ctttgaataa aatgtccgct aatttaatct tttcgttgag 52381 gaaatccctt agctgattga gaaacgtatc taaattttta gaattaaata tcacggtact 52441 cccaccgctg tcctcttccc ttggttgttc ggcccaaaat aattcatcat tagacggcaa 52501 aaccgttaaa ctgggaggca aatcagcctt tgacttgaaa aattcgatag cattgctttc 52561 ctcattagat atcaataaaa ttttcatgaa acgagcgacg gcagctaaat tattagactg 52621 gtaattcaat tctgactctt tgagaacaga attaatgaag atttccctaa gaatgttgaa 52681 attagtttca atcctagtaa atgtttctat atcattttta ttcgagaaat tgtacttttt 52741 gataaaattt agaattcttg tttgtttcaa cggatcgttg gaatatgaag taggaaagaa 52801 atttgctaga ttattattat atagcttcct agcgtatgag ttataacaac ggtaaaattt 52861 cacaaagatt tttttagaat tttgagcagt gaaagatttg tatatttcga agatgcgaag 52921 ggaattttga ttatcatttt catccagcaa cgtaatttct tcttcttcat ttgaatgcac 52981 ctgttggaga cccattctag tcaatttcaa tgaccaatac tttgaatcat ttttgccgtt 53041 aatgattgca taaacccgtt tattcacttg ttgaaaactc agataatcta cagtagataa 53101 atatgaggca atattggtta caatctcggg aacttttagc agatcatcca ttttaccgat 53161 ttcctcaaaa gcttttgttt tcttttggtt tttctattgt ttgtctgttg accatttttt 53221 gataaaataa gaaccttcct tcaacgaaat atttcggcaa aagttagcct tgaaacactt 53281 aaatacagga agaaataagg taaagcgtaa aactaacagc aataatttgc agttgtataa 53341 atggaaccag aagataccca gctgaaagag gacattaaaa ccacagtaaa ttacataaag 53401 cagcatggtg ttgagtttga gaacaaactg ctagaagatg agagattctc attcatcaag 53461 aaagatgacc cactccatga atactacacc aaactcatga atgagccaac agacactgtc 53521 agcggtgaag ataatgacag aaagagtgag cgagagatag caaggccgcc ggattttctg 53581 ttctctcaat atgatactgg aatatcccga agagacatgg aagtaatcaa attgacagca 53641 cgctactatg caaaggataa aagtattgtt gaacagatga tttcaaagga tggtgaagcc 53701 agattaaact ttatgaacag ctcacatccg ctacataaga cattcactga ttttgtcgcc 53761 cagtacaagc gagtatattc ttttactggt caagaaatca agaaaagtaa gagaaccatt 53821 ttagataatt gttttgagag aacacagtat tgggaatttg agaaagataa agaccgggaa 53881 catgataagc tcgtagagtt gtgcaaaata caatttgcag ccattccatg ggataaattt 53941 actcaagtgg caaaattttc tatccctgaa gacacagaaa tcttcgaagg ctctctagat 54001 ttagaacaga tgaggctgcg aagagtacaa actggtatta agttattcga tagtatcaag 54061 ccgacaaatg aagaagaaaa gatagtatcc gaccaaggta agcaaaaagg aggagatagt 54121 aagggcaaaa agcgtaaaat tagagctgtg ggagagacaa ggttaaagaa aagtaaaaaa 54181 taagcctcat gaaaatcaaa gttagctaga agtatgtaaa ggttgatgat gcaccgtaat 54241 tgagcacatg tatcactatt aacggcgtac gtattttggc gttttttcat gttgatgtta 54301 ttttgtatat agaaagtgaa attctcgagg atatggccct actggataat actattggta 54361 gcgtgaaaga aggccaggat gatagatatc aacgttaata acatattttt tagatcttat 54421 tcagttgatc ctaactctgg tcacgcaatt tatgtctttg attcgactta tttgccagca 54481 tctgatgaaa ttggcgataa gcaagtttat gacttgctta ttaatgccct catggatcga 54541 ttggtaatga aattgccaca ggcaccatat tcactggtga ttttttcatc tgggttttcc 54601 cagagaaaaa taagctgggt ttacggtatt aaaatgtttg caaagttacc caaagagacc 54661 aagttctatt tacaaaagat ttttattgtt catgagtcat tcttcgttag gtcggtctat 54721 caagtaattt caaacgctat gaactttaac ttcttggact caaaagatag tcagcatgat 54781 tttccaagtt tagttcatgt cttggacctg acttctttat ccgagctaat agatattacg 54841 cgacttagaa tatcgttgaa cgtgtactta tatgattacc agatacgcga acatataaat 54901 gtcccggagg aatattataa cagattgacc cctctggcaa taagacagta taggcagtta 54961 gtattcgata aaattttcaa gaaattacag aatgacgctc tgttgtgtga attgatattc 55021 cagaagccgg gaaactataa aaaggtaaac atttttttgg atattatcaa aagaaacaac 55081 tacattgatt tatctcaatg ggatatttat tctttggcat ccgtgtggtt gaattacttc 55141 attaagaata aagccaaacc tctaatccca attgaattaa ttccgttacc aattgttgat 55201 gatctaaagt tcacaagtga aacattccgc aaaattatta aattcaacca ataccaggac 55261 ctctttatgg tcataattcc tttttttaat aggatcatag cgcatggtga atcgactaaa 55321 catgattcaa ggaccctaag taaagcttta actccggcgt tatgtaagga aaaactttcc 55381 atgatgacta atgatcgttt agctattggg tcgagatata ttaaaaattt actggacttt 55441 ttccccgaaa tcgcgaagga aatatcatca cctccttcat ccgtatcatc gtcttctact 55501 atccctgttt tgcctaagcc aaggaagtcg tcgccaacca gatacagtga actaggctgc 55561 ttaacccttc ctagaagtcg aagccctagt ccacaaagat ctgttacgtc tccaacgtac 55621 acacctgtcg cattacaaaa tacaccagtc ttgaaaccta agtcttcaag cagaaatgtt 55681 tcatccccat cattcaatgc caaacctcca cttcctatta aggcagttac acgaccacaa 55741 ctgtctctaa cttccaattc taatacagat ttggcattag cttcttcttc tacagataca 55801 ttatcctcac cgacgaagac tccatcagca gactcgcttc cattgagtaa cagcagcacc 55861 gatttaacga tatcagataa tatcaaagaa atggttaagg acgagccagc aaaggataaa 55921 aattctgtgg aaacagatat attcgtacaa cagtttgaaa gtttaaccct cgtccaaaac 55981 gcgaagatta agaagttcga caaagaacta caagaaaaga agaagaaaaa tgaaactact 56041 tcaaagacag cagataaatt ctctcaaaag ggatattcag atattaaagc aagcaacaag 56101 gttagcaggc tagctgcatt gtacgaagaa cgtttacaag gtttacaagt aatgaatgaa 56161 atgaaacaaa ggtggtaact tacataattg tatcttttta acacatacat attgcatata 56221 cgacaacaaa atacccccca cccttgagtt aagccgtagt tgaagcagtc gagatctcgt 56281 gtataatatt atatatcaaa caatattacg ttttttatag taaataaata aataaatagg 56341 taggttattt gcaccgtcta tatgcagagt ctatagaatt gtgtaaacta gcttatgact 56401 attaaatcgg actcttaatt tttagctaat atctcttcag aatttattcg tttcttcgta 56461 tattaccaat ataattgatt gctgaaccag ctttgaaaaa atcgatttga tctttagaca 56521 tagtatgttt tgccttgatg gtgaacgatt caccgtttgg tttagtaatt ttaacatcaa 56581 tttcaccacc gttattacca tccttagcaa tcatgtcaac taggttcaac gtttctaaaa 56641 catctccgct tgatatttta tcatagtcag attcgttggc aaaagtcaat ggcaacacac 56701 cttgtttctt caagtttgtc tcatgaattc ttgcaaaaga cttaactaaa agaatctctc 56761 cgcctaaaaa tcttggtgac aaagcagcat gctctcttgc ggaaccttca ccatagttat 56821 gttccgctat cacggtccat ggtctaccgt ctgatttcca tttcatcatc aaaccaggaa 56881 tatcatattc agttccgtca aggtcataag ccttgttgac ttcaccggtt tctttgtttt 56941 gtgcaccaat caatgtattg taagaaatgt tttctagatg gcctttatat ttcaaccaga 57001 cgcccgcagc ggaaatatga tctgttgtac atttaccttc aactttcaaa agcacgtttg 57061 tcttcaattc cttcccgttc caaggtttga atggctctaa taattgcaaa cgatcagaat 57121 tagggtctac cttaatctct acattgctat ctggctttgg atccatttca ggataaaatt 57181 tgtctctacc gtgttcaaat cctctttttg gtaactcatc accctttggt ggttggaatt 57241 tgaaatcctt cccatttggc aatttaattg agtcagttag cggattgaac tgagcatctc 57301 cagaataact catcgctgtt actatttctg gggatgttaa gaaattcatt gtattcctat 57361 taccatcgtt tctagctctg aaatttctat tgaatgatgt aaaaatagtg ttcgtttctt 57421 ttgatgtttt cgagacatct tccctattcc attgtccgat acaagggccg catgcatttg 57481 ctaaaacttt ggcaccattt tcttggaaaa tatcgatgat tccatctctt tccaaggtag 57541 ctctaatttg ttctgaacca ggggtgacaa agaaggggat acgtggtttc aagccggctt 57601 tggaagcttg cttgaccaag tcgacaacac gactcatgtc ttgataagat gaattggtac 57661 atgatccaat caaaccagcg ctaacttttt ggggccagtt ttccttcaaa cttttttcgg 57721 catattgaga tattggggtt gaaaggtctg gtgtaaatgg accattaacg tgaggttcaa 57781 ttgcggataa gtcaatttca ataactttat cgtattgagc atctttgtcg gctcttaaga 57841 agttaaactt gtttaaagca acatcagctg cttcagcgac ctctgctcta ttagttgctt 57901 gcaaataacg cttgtgagct tcttggtaag ggaaagttga cgttgtagca ccgatttcag 57961 ctcccatatt acagatggtt gccatacctg tgcaagatag agtggataca ccttcgccga 58021 agtactcgac gatataacca gtaccacctc tgacagttag taaaccagcg agctttgtga 58081 ttacatcttt aggagtggac catccgttta actttccggt caatttaaca cctaaaattt 58141 ttggtgcttt taattcccat ggagtgcctg tgagggcatc aactgcatcc gcaccaccaa 58201 ccccgatggc aatagctccc agaccgcctg catttggtgt atgggaatca gtacctagca 58261 tcattagacc tggagctgag aaattttcca aaacaatctg gtgaatgata ccagaacctg 58321 ggccccagaa ttgaattcca tatctctttg cgcaactctc caagaaatcg aaaacttctt 58381 ggttggtagc tatggaagag ggtaaatctt tagtttcacc gtccttacct acaattaaat 58441 gatcacaatg tatggatgct gggacagatg tttgatttag accggtggtc atgaattgta 58501 gaagcgccat ttgggcagaa gcgtcctgca tagctacacg gtctgggttt agcttcaagt 58561 atttattacc acggatggtg gacagatcag aagaagtaat cgattcttca ggatcgcaaa 58621 gatgcgagta taaaattttt tctgctagtg tcaatggagc attgtttgtt atttgtttaa 58681 tcttgtctag gttggtcaaa agttttgcat aaggtggcac ttttgtttga aaatttttag 58741 atacagaggg gaacatattg gcatgtgttg ccaaatgcct ctttatataa aacctattag 58801 ctgaagatag catcgaatct cttgcttatt gctcttagag ttttatgttt aaagaaagtc 58861 gaaaattctt atttttgcaa gtgcgcaaat cgaataatac gaaaagatga aaatatttta 58921 gtttatatac atgtttgatg ccataccatc tattgacata atctacgatg tgagagctgt 58981 atgatattgt ggaactttgt atatattgaa aaaattttcc agtggaattt tactcgcgat 59041 gactcaagag cgtgaaaaaa aaaaaaaaaa aaaaattaat tgctaaaaaa tcaaatatat 59101 gcttccaatc ggatttgaac cgatgatctc cacattacta gtgtggcgcc ttaccaactt 59161 ggccatagaa gcttctattt tatatttgcc tgacctattt taacggttat attccacaaa 59221 cattttaatc atgaagcaat ttttttgatg ttgatgtgag agtaataagc actgtgctga 59281 gaagaggatc aacaacatga tattctacgg aacgtaaagg atacaatgtt attggactaa 59341 gaatcgtcta tcatcttaag aaatgggtgg atgatcggac aattattgag aaggtttcat 59401 tgtggagaac aaatcgcaat attgtgcaat cctttagata tgtcaagata aaatactagg 59461 gaggcttcgc ccattcatta aagagtatag ctaccgcata ctgtttagta gtatactatc 59521 acatgtggtg taaaaagata acataaagat tgagaatcag tcatcaaatg taatggaagc 59581 tgaaaatgca aggattgata gtgtaatagg aacgaaacat atgaaaacgg aatgaggaat 59641 agtcgtatta ttagtatgta tagattccat ttgagaattc ttatatcctc gaggggaact 59701 tctagtatat tctgtataca taatattgta gcctctatca acaacggaat cccaacaatt 59761 atctcaaaac tcacttatat ctcacaaaac actcaatagc gacccttaaa tgttactgaa 59821 cctcatattg tttcgctctg ctcccttata tattgttaat gcaatcggga cagctcactg 59881 actgaacggt gaatagtggc tcccggaaag ctgagagttg tgaactcgcc acctctgtta 59941 agtaagtcgt aagctgttaa agctgcgtca cgagtaatga gctgccagtt cggcctctga 60001 tcgctgtact ttatggtaaa aagatagttc ctagtagaag acgagtcata ctcgtaaaca 60061 agcaccgctg gatactcttc tctatcaaga cgtaaagcgt acttgtaatc tctaagttcg 60121 ccaatccaaa tttctgatat gccactcatt atcctcaccc cacatgctga caccttatac 60181 attcaatatc tcccttctcc tacttaacct tatgttaccc tttttttttg gcttgcattt 60241 atatttggtt tacatagcaa caaccgatag cgggtaacag cattaagctt cccatctccc 60301 gttcactgtt attacctttg gcacgtaaag ggccggctaa taatgtcgta tttccactga 60361 tttggatgta tgttgcatgg tgctagattg tgaataaatc atttccactg gtttctagca 60421 gaggtaagaa aatcagtagt agcggcagca gccaagaaaa atggcagcct ggcaagcagc 60481 gaaggccatc tgtgctgcat ttccacactc cttgtatgac tgcatacgca taaagaggtg 60541 ccttgctgta ggcgtatatg atcctaagca acagagaaac cacggttctc ttctcttctt 60601 atttcgttat tgtcttccct ttttactatg ggtaaagtcg ccctaaagcg gggcgctcac 60661 aatatcgccg cagctacagc cgtttttttt ttttttgttt ttttttgcgc tgcttctcga 60721 agaatgaatg gctcactgaa aaattttgat tcatcgatat aaagaacact gttcacttcg 60781 atgtcatccg gccaataaag ttgtttttag gataaacgag taagtggtag ctggtacagg 60841 atcatgagat tttcacactt cttgaagtac aatgctgtcc cagaatggca aaaccattat 60901 atggactaca gcgagctgaa aaatcttatt tacacgctac aaacagatga acttcaggtt 60961 ggtgataacg aagaaggatt tggcgcagga aagagctcta acattacaga taggttcaaa 61021 aacaagtttt cttttaaaaa tgcgaaggaa gatacgtctt ccggtatgaa caaagatgca 61081 ggcatcgttg aggaaaccat cgagttgcga gagttgccta ctgctcagac ggtcgctgcc 61141 aaaccttctc ctttcagaag aatgaaggaa aagatatttt acaaaagaag gtcgtcttcc 61201 gcatcgtccg tctcctccac ggccaacgaa aatctgcaat tagacactta tgatacgttt 61261 gttggtgatt taacagctga aaaacagaaa gtagatgatt tttataagag gacagaagcg 61321 aagttctacg acaaatttga cgcgctggtg aaggacctga agaaaatcgg agttatagaa 61381 tacgatatcg acgatgatac tctgtttaac gaaccgattg ccagcacaaa tgacgaagtt 61441 cccccactag acttggatga tgacgaagac gacgacgaat tttacgatga tcaatctaat 61501 attgaagata atactgcttt gctgcatcat tcgcagtata acattaagtc tcagaaaaaa 61561 tcgctgttga agaagtcgat cgtaaaccta tatatcgatc tttgccagtt gaagtcgttc 61621 atcgaattga accgcattgg gtttgcaaaa attacaaaga aatcagacaa agttcttcac 61681 ttgaatacaa gaaccgaact gatcgaatcg gagcagtttt tcaaagacac atatgcattc 61741 caggcagaaa cgatcgaatt gctaaattcc aaaatttccc agctagtcac attttatgcg 61801 cgcatcactg accggcctca taatatctcg catagcaagc aagagttgaa atcctacctg 61861 catgaccaca ttgtttggga aagaagtaac acttggaaag acatgttggg actgctatcg 61921 caagctgacg agttgacacc aaaggaaaca gaatataatg caaataagct ggtaggcaag 61981 ttagatttgg aatactacag atggccacta cccagaccga taaacttaaa attcactagt 62041 ataaacaacg ttgcactacc gaaattattt ttcaccaaga aagcatacaa gatttacttt 62101 attattctag tcactggact cttgttagga ataaagacct tcaacgacgc tgctcagcac 62161 cgctgcatgg cccttgtcga gtgtgtcgcc tttttgtggg ctagtgaggc catcccatta 62221 cacattacag cattccttgt accactactt gtagtccttt tcaaagtcct aaaaacctcc 62281 gacggggcta taatgagtgc tgcaagcgct tcatcagaaa ttttggccgc catgtggtct 62341 tctacaatta tgattctgct ggcaggtttt actttgggtg aagtacttgc acaatataac 62401 atcgccaaag ttcttgcctc gtggttgttg gccttcgctg gttgtaaacc cagaaacgtt 62461 cttttaatgg caatgtgtgt cgtgttcttc ctatcaatgt ggatttccaa tgtcgcagca 62521 cctgttctaa catattcgtt gttatctccc ctattggatg ccatggatgc agatagccca 62581 tttgcgcaag cattggtgtt aggtgtagcg ttggctgcaa atatcggtgg tatgtcttca 62641 ccaatctctt cacctcaaaa catcatttcc atgtcgtact tgaaacccta tggtattggc 62701 tggggccaat tctttgctgt tgcattgcca tctggtatcc tggccatgct tttggtttgg 62761 attttattgt tcactacttt caagatgaat aagaccaaat tggaaaaatt taagcctatt 62821 aagacgaaat tcacagttaa gcagtattat atcattactg tcactgtggc cactattttg 62881 ttgtggtgtg tggaaagcca gattgaaggt gcttttgggt catcaggtca aattgcaatc 62941 attcccatcg ttttgttttt tggtaccgga ttactatcaa cacaagattt aaatgccttt 63001 ccgtggtcaa tcgttatttt ggcaatggga ggtattgctt tggggaaggc cgtctcatcc 63061 tcgggtttgc tatcaaccat tgcaaaagca ttacaaaaga aaattgagaa tgatggtgtt 63121 tttgccattc tatgtatttt cggtatcctg atgttggttg tgggtacttt cgtctcgcat 63181 acagtatccg ctattatcat cattcccttg gtgcaagaag ttggtgacaa gcttggcaac 63241 cccaaagctg ctcctatcct tgttttcggt tgtgcattat tgtcatcctg tggtatggga 63301 ctagcttctt cggggttccc caatgtcact gccatctcta aagtagatag aaagggcgat 63361 cgctatttaa gtgtcatgac tttcttaacg agaggtgttc cagcttctat tttggctttc 63421 ctatgtgtca ttactctagg ttatggtatc atggcatctg ttgtcaaggg taacgcaacc 63481 tctgcgtaag agatacgtct acgatagcat gtaacagcgt atatataatc tatatgtatt 63541 cgattaatcc aacacttctg ttgtgtagtc taatgttcga aaaaaaggta cgcttccctg 63601 ttataatcag gtatatttcg ttattcttat aagctaaaag attaaaaatt tttccacttt 63661 ccttgaaatt tggtcggttc gtggaaaaat attattacgt attgaagaag tgcatgaaga 63721 taaaagatgg gattactgga aaaataaagg gaggaaaatc ctgcagaacg ttgttgtttc 63781 aatcgaaggt ttcttcattc gaaaatgggt tcttcagatg tttcaagtcg tgaatgttca 63841 ttggtttata atgaagatcc cgatttcacc gatggcacaa caccatgtga tcggttggga 63901 gtggacttga tgaatgttct agatgacaag gatgaaataa agcaagagtc tgtcccagtc 63961 tcagatcgtg aaattgagga tacggaatcc gatgcttccg ctgtttcttc atttgctagc 64021 gctaatgagt taatagctga gccacacgct gcaagtgaaa ctaatcttgg aactaatggt 64081 caagatggaa gaaatgtctt agaacaacaa agagacgtgg ttgctagact aatagaagaa 64141 aacaaggaaa cgcaaaaaga gggtgataaa gtctgtattg tccccaaggt ttggtacgat 64201 aaatttttcg accccgatgt taccgatcct gaagatatag gccctattaa tacacgcatg 64261 atttgcagag actttgaaaa ttttgtgctt gaggattaca atagatgtcc gtatctgtct 64321 attgcagagc ctgttttcaa ttttctatca gaaatttacg gcatgacaag tggctcttac 64381 ccagtggtaa ctaatttggt tatcaaccaa accacagggg agttagagac agaatacaat 64441 aaatggtttt tcagactaca ttacctgacc gaaaaacaag acgggaggaa aaggaggcat 64501 ggccaggacg attcaataat gtacctctcg atgtctgcgt tgaatttagt acgtgatttg 64561 gttgaaaaga gtatgaatct gttttttgag aaagctgatc atctagacgt gaatgcggtg 64621 gattttaaaa tttggtttgt gtcagaggga tctgatattg ccacagatag caatgttagt 64681 acttttttga attcttcata tgaaataact ccgcttcaat ttctcgaact accgataaag 64741 aaactactaa taccagacat gtttgaaaac cgtttagaca agataacttc aaatccgagt 64801 gaccttgtca tagaaattaa acctatagaa gggaatcacc attggccttc aaactatttt 64861 gcttataata aactcgaacc agcatcaggt actactggtt tggtcaattt gggaaataca 64921 tgttacatga attctgcgtt gcaatgcctg gtacacattc cgcagttgcg tgattatttc 64981 ctttatgatg gttatgaaga cgaaatcaat gaagaaaatc ctcttgggta ccacggctat 65041 gtggctaggg catttagtga cttggttcag aagttgtttc aaaacaggat gagcataatg 65101 caaagaaatg ctgctttccc cccttcaatg ttcaaatcca ctatcgggca ctttaattcg 65161 atgttttctg gttatatgca acaggattct caagaatttt tagccttcct gttagacagt 65221 ttacatgaag atttgaacag gataataaag aaagaataca cagaaaaacc atcattatct 65281 cctggtgatg acgtgaatga ttggaatgta gtcaagaaac tggcagacga tacttgggag 65341 atgcatttaa agagaaattg ttccgttata acggatttat ttgtcgggat gtacaaatca 65401 acgctatatt gtcccgaatg tcaaaatgtt tctataacgt ttgacccgta taatgatgtt 65461 acattgccgc ttccggttga tacagtgtgg gataaaacta taaaaatttt tcccatgaac 65521 tctccaccac ttcttcttga agttgagtta agcaaatcgt ccacttatat ggacttgaag 65581 aattatgttg gtaaaatgtc gggcctagat ccaaatacac tatttggctg tgagattttc 65641 agtaatcaaa tctatgttaa ctatgagtca acagagtcga atgctcaatt tttaaccttg 65701 caggaattga tcaaacctgc tgatgacgtt attttttatg aattaccagt aacaaatgac 65761 aatgaagtaa ttgttcccgt attgaatact agaattgaaa aaggctacaa aaatgcaatg 65821 ttatttggag tccctttctt tattacgtta aaagaagatg aattgaataa tccaggtgca 65881 ataagaatga aattgcaaaa caggtttgtc catttaagtg gtgggtatat cccatttcct 65941 gaacctgtag gaaatcgaac cgattttgct gatgcttttc cattattagt agaaaaatat 66001 ccagatgttg aatttgaaca atataaagat atactacagt atacgtctat taaggtgact 66061 gacaaggata aatccttttt ttccatcaag attctgtctg tagaaaaaga gcagcaattt 66121 gctagtaata accgaacagg gcctaatttc tggaccccta tctcccagtt aaaccttgac 66181 aaagctacag atatagacga taaacttgaa gatgtggtga aggatatcta caattattca 66241 tccttagtag attgtgctga aggggtcctt atgcaagtgg atgatgaggg agataccgag 66301 ggtagtgaag caaagaattt ttccaagccc ttccaatcgg gagatgatga agaaaataaa 66361 gaaactgtaa caaataatga aaatgtaaat aatactaatg atcgggatga agatatggaa 66421 ctaacagatg atgttgaaga agatgcaagt acagagccag aattaacaga taagccagag 66481 gcgttagata aaattaagga tagcttgact tccactccgt ttgcgattct ttctatgaat 66541 gatattattg tttgtgagtg gagcgaattg ggttcaaatg aggcattttc cgatgataaa 66601 atatataact gggaaaatcc agctactttg cctaacaaag agttggagaa cgctaagttg 66661 gaaagatcta acgctaagga aagaaccata accttggacg attgtctcca attattttcc 66721 aaaccagaaa tactaggatt aaccgattcg tggtactgcc ctacatgcaa ggaacatcgt 66781 caggctacca aacaaataca actttggaat acaccagata ttctgctaat tcaccttaaa 66841 aggtttgaaa gtcaaaggtc ttttagcgat aaaattgatg ccacggttaa tttccccatt 66901 acagatttgg atctgtcgag gtacgttgtc tataaagatg atcccagagg tttaatctat 66961 gacctgtatg cagtagataa ccactatggt ggtttgggtg gtgggcacta taccgcgtac 67021 gtaaagaatt ttgccgacaa taaatggtac tattttgatg attctcgagt aactgaaact 67081 gcgccagaaa atagtatagc tggatcggct tatttgctat tttacattcg ccgtcataaa 67141 gatggcaatg gattaggcag ctctaaacta caggaaataa tccaaaagtc acgccacgga 67201 tatgatgagc gtatcaaaaa gatatacgat gaacagatga agttgtatga atttaataag 67261 actgacgagg aggaagatgt ttctgatgat atgatagaat gtaatgaaga tgtgcaggcc 67321 cctgaatata gtaatcgtag tttggaggtt gggcatattg aaactcagga ctgcaacgac 67381 gaagatgaca atgatgatgg tgagaggaca aattcaggta ggagaaagtt aagattgttg 67441 aaaaaagtct acaagaataa ttcaggcttg ggttcatcga gtacgtctga aatatctgag 67501 ggatgcccag aaaacgaagt cgctgatttg aatttaaaaa atggtgtgac actagaatcg 67561 ccagaataat gacatgagtt tatatgatag ataaaattaa taaatttcca catgtataat 67621 acttttcaat ctttttcgcc tactatttac tgcctaggct aataaattat atgtttttgt 67681 cctgggcgcg acattccaaa aaaaaaataa aaaagaagag aaaatactgg cttatgaata 67741 caaaaattac ataaacgaag caaaatgatt atttcgaata aaacagtcta tatataagtc 67801 aaatacaaga taggaagaaa aacagaaaaa aacaaaacag aaggactggt taattgtttt 67861 tgttgatctt cttcttacca ctagcacttc cacgtttgta aacctcaata tagaaagaga 67921 tgaacaaaaa caagtaggat gtaagaatgg ctgcaccagc agcaatagcc gtcattgaac 67981 ctaagcaatc ctcacactgt ggagtacaag catttttgaa atatgcagca acaatcttct 68041 gataaagcac gtaataaacg acaatgagat caagcatgaa ctgcacaatt tgtagtcttg 68101 taacccaggc tttccaccaa acacgaattc cgctagcaga aaggaaataa taccaataca 68161 taagaacgtg aacagctaag tttaaggtga caggaaccca tgtaactgct gtgtaaccaa 68221 ccaattgatt atagcacagt aaagctgtag caccatgatg gtatgtatgt aggaaagtca 68281 actttctatg tttcaacacc atcaagacag tgtctgcgaa ctccacaaac tttgtcatat 68341 agttgagata atataatgtc tccatcggtt gcgtccacga ttcaacatta caaacagcaa 68401 aatacagccc atggcgatac actatgggta gcatctgttc caccatcaaa atcaaccata 68461 aaaaggaaac agaagtcaac atcaagttat ggacttgaga aataaatctc aacttgagag 68521 gtttacatga ctttaccagg gacctcccgc caaatataac cacataatac atggcaataa 68581 aaagcagtac cggacgaggt tcactcaaag gctgcttccc aacggtaaac tcaaaatcct 68641 ttggctggaa gcgacctgca gtggcccacc caaccgcacg attgaaatag tcccacaaat 68701 aaatattaaa aaaaggccta tctattgttg ggcgaaacct agaggctttc tcgaggcaaa 68761 aatttttcca atcacttacc atacttgctt gcaaatttag ctctcaagtt ccttaaaatt 68821 gataaggtat cctaccttaa tattcatatc agttagtctt atatacttct acctcttttt 68881 ctggcttcct ttctttccct tatgtccttc ggtttactaa tccgtaaagc cgacgcgggt 68941 aagccaagac cctgagttta gaactaatat ttcgtcacgt cacgtaagtg caaggtaata 69001 aaagcagcag aaatatctgt agtttcaaca aaatatgtct ggcttgcgat ttgttgtgtt 69061 ttgaaactag ttgctagtct gcattccttt gttttccctg aattacccaa agaagaaagc 69121 gacgcgaggc ctcacgcgtc ggagtttcca gatcaggaaa ttacccactt aggaaattga 69181 gttggctggc agaaaagata taacgccatc ttgaaaaata gtattagtta gtctattttt 69241 tcatttatat agtagaggta tattctctgg aagaacaatt ttggaatatt cagaacactg 69301 cgctgcacta ttttcatcaa tagtaccata tacgttcatg tcagctatac caataactcc 69361 aactaagcgt atcagaagaa atctatttga cgatgctcca gcaacgcctc cacgaccttt 69421 gaaaagaaaa aagttgcagt tcacagatgt tacaccagaa tcatccccag aaaaactgca 69481 gtttggctca cagtctattt ttttgaggac aaaggcactt ttgcagaagt catctgagct 69541 agtcaacttg aatagcagcg atggtgcatt gccagcaaga acagcagagt acgaacaagt 69601 tatgaatttt ttggcgaagg caatttctga acacaggtcc gattcactgt acatcacggg 69661 tccgcctggc actggcaaga ctgcccagct tgatatgatt ataagacaga agttccagtc 69721 cctcccattg tcgctctcca cgccacgctc gaaggacgtg ctgagacata cgaatccgaa 69781 cttgcagaat ttgtcctggt ttgaattgcc cgatggaagg ctagaatccg tggcggtaac 69841 cagtattaat tgtatatcgt tgggagagcc gtcctccatt ttccagaaga ttttcgattc 69901 cttccaagat ctgaatggcc caacattgca aataaaaaac atgcagcatc tacagaagtt 69961 cttagagcct tatcataaga aaactacgtt tgtggttgtg ttggacgaga tggacaggct 70021 attgcatgct aacacgagcg agacacaatc agttagaact attcttgaat tattcctttt 70081 ggcgaaattg cctactgtga gttttgtgtt aatcggtatg gctaatagtc tagatatgaa 70141 agataggttt ctttccaggt taaatttgga cagagggttg ttaccgcaaa ctatagtttt 70201 tcagccatac actgctgagc aaatgtatga aatcgtcatt caaaaaatga gtagtctgcc 70261 cactattatc ttccaaccga tggccatcaa attcgcagca aagaagtgtg ctggaaatac 70321 gggtgacctt cgaaaacttt ttgatgtctt aaggggaagt atcgaaatct atgagttaga 70381 aaagcggttt ctgctttcac caacaagagg atcattgaac tctgcgcaag ttcctttgac 70441 gccaactact tctccggtaa agaaatcgta tccagaacca caaggtaaaa taggcttgaa 70501 ctacatagcc aaggtcttct caaaattcgt gaacaataat tctacgagaa cgaggatagc 70561 caaactaaac atccagcaaa aattaattct ttgcaccata attcaatcac tgaagctaaa 70621 ttccgatgct acaatcgacg aatcgtttga tcattatatc aaagcgataa caaaaactga 70681 tactttagca ccattgcaga gaaatgaatt tttggaaatc tgtacaattt tagaaacttg 70741 tgggctggtt tcaatcaaaa agacaaagtg taaagggaaa accaagagat ttgttgataa 70801 gattgatgtt gatctcgaca tgcgagaatt ttatgatgag atgaccaaaa tttcaatttt 70861 gaaacctttc cttcactagt cagctaatag atttattttt tctttttttt ttacagttcc 70921 acttgcatcc ctcatttttc acattccttt ttttatagaa aagcatatca ctatataaaa 70981 attctattat agttgtaaca gcatagcata ttatagactt tttttttctg gaaacggtta 71041 aaccgtttgg ctgagatgca atgatatacg caacattgca ttcaaagaaa ttgcaaaaaa 71101 gacacaataa aacgtaattt gtacaaatat tttactatca ttagctactg gatgcagaat 71161 ggatgattgt tagggggagg tggggtacaa ttgtttgttt ttgatacatt ttctctttca 71221 aatcgcaacc aattcactct gctaatgtga taacaatggc gcctgtcgga aaggtgaaaa 71281 aaaaaaaatg caaacaaata aattggcacg gtgtgacata tgccttctat aataatgaag 71341 gaactcgaag aaaaagggga aaacgatgtt tcaacagctg tcggcatcca ttaggcacaa 71401 tgcacacata atttttttat gcataagttg gtattttatt tcatcgttgg catctcaggt 71461 aacgaagcag gtactaacgg tttgcccatt accacttttt ttgggtgagt ttcagttcat 71521 ttatactgct gtgctagcat ggtttacgtg ttatattgca tatagtttcc caggattcta 71581 tcgcatattt cctaatggta cttttccgga atattatatc gacgacagag aaactagccg 71641 tgcagctagg aaagaatcaa aactatcctc cctcattata ccgccctcta aaccaatcct 71701 gcaaacagtt ctacctttag gtcttttcca atttgtaggg aaatattttg ggcatacagc 71761 tacctctttg gtgcctgttt ccacggttgc aagtataaaa acgctatccc ccatgtttat 71821 ccttttgctc caaaagattt tgaaaatatc cactttgaaa attactttaa ctcttatctt 71881 tagtttatgc actttagttc ttggagtttg gattatagtt caagaagata atcgttcacc 71941 ggcctcttcc aatgagctga gagaattctc taaatacggc gtaatatgcg ctatgatatc 72001 aatgttcatt tttgtcttgc aaaatatata tggcaagacc gtgttcacgt acagatctca 72061 aacagatgaa tctcaaagta attctggatt ctcacggcaa gaatcacctt tacccttata 72121 tgaaaagttg gatgagaaac ttgttgcgaa aaagaaacct aaatcatatg acaaattgac 72181 tttaatgatt tatatttccc ttgttggatt ttgtttatcg tttggctggt ttatcactct 72241 agaatttcct gtactattta ggtatttttt tcaaattaac agctcttcta cagtaataaa 72301 agcttttcca gtctctttat ttttactgaa cgggacattc cacttcattc aggcaatgat 72361 tacatttcat ttactgggtg aggtctcaac tttaacatat tcaatagcga atctgatgaa 72421 gcgctttgcc attattgcgg ttagttgggt ctttattgga agaagaatta cttggctgca 72481 agtgttcggt ttggttctga acacattagg gttattcctt tatgaaagat gcacatcaca 72541 atcgaaaata aaagcgaaaa tacgtcctga gtagtttaac atgatagaat ataaatgcaa 72601 ataatattta ttccctttag gaaatacggg tgttttgaat ttacttatct gtaccataca 72661 taaaatttac atataataat agaatcttta tcaacacata atagtcactc tactttgagg 72721 caacggcagc atacttttct ctttgttttc tttttgcctc ctctctgatg gctcgagctg 72781 tttcggggtc caacttttct actatgattg ggaaaacgac aagggcaatt aaggtaataa 72841 cgcccgccag tttccaacgt gagttcaaaa tattacccac aatacctgta gaaaagatac 72901 tgacgtttct agcctgtaaa taagatctaa tcggggcctt atgtaaaagc tccactgtaa 72961 tataagggtg caccttcata gattgtaatt tttctgggta cgttatatct ttggatggga 73021 aatattctct tccaaaaaag ttcttgaacg cgttcaattg taaggtgcca ttctctaaat 73081 tcttgaattc aataagaatt ctgtttggct tcagattgaa gtccatagat gctgggtaca 73141 tcacatagta tgtcgtttca ttaacaccgt cgtttaaagg gagattagcg aattcaaagt 73201 tgccttcgtc atcttgaaac atggtcgtag atgtgtaagg atattctgtc gaaaaattgc 73261 cgatctgata aagtttgaaa cttgttctag ttgaaacaaa gccggtgatg ttacttgctg 73321 ctaagtctaa gcgaccctta atggtccctc tcctggccgt agcactggcg acataaataa 73381 atgcactgag taaaagaaca atctgtgaaa acatcgtcac actgctcttt cacttgttga 73441 tcaaatttac tttgatgata tttaatggct tgacaaattc gttcatctta atttcataca 73501 taatttcatc ctgaaatcct cgatcatttt cgagactgtt tttcgagctt gattttatat 73561 gtggtgtaaa cacatcattg tacatccttg caccacactg aaaagaatat ggaaaaaatt 73621 tcaaactttt taatgggtga tagacttgaa aaacaaaacg gaataaaaga tatagtcgca 73681 agaacttgcc ttctacgagt ataaaagcgg tactattcct tctgtatgca tcttcatcgc 73741 aagagagaaa aagactgaaa tcaacaactc ccaataacaa ttaagaatgg ctaacggtac 73801 gtgaaagggg tgatatcctg tttaaaacca tttagttatt ctttttttca gatggagact 73861 gtgatcgggt agcgcatgat gttattattg gaattttatt ttttttgcaa ctttgaagca 73921 ctcctaacta tattgcaata gtgttatgag atgctactta tgtttgtaag gccatgaaat 73981 tctgtaatac ggagttaaaa tttctgcaat aaagcacttc aatgctattg tgttatagag 74041 gctctgcgct cacccttaat actgtatcat ctgtaataaa gaatgtttat cttaaaagga 74101 ttgtaactaa atggttgtta gatagtgact cattcgttta ttttttaata atcgaaaaag 74161 cagaagttct gtttactaac aactatacct cttatcatgt atagaccttg ttcaagctcg 74221 cgataactct caagtctttg gtgttgccag aatctacgcc tcctttaacg atacctttgt 74281 acatgttacc gatttatctg gtaaggaaac tatcgccaga gttactggtg gtatgaaagt 74341 caaggccgac agagacgaat catctccata cgctgctatg ttggctgccc aagatgttgc 74401 cgctaagtgt aaggaagtcg gtatcactgc cgttcacgtt aagatcagag ctactggtgg 74461 taccagaacc aagaccccag gaccaggtgg tcaagccgct ttgagagctt tggccagatc 74521 tggtttgagg attggccgta tcgaagacgt tactccagtc ccatcagact ccaccagaaa 74581 gaagggtggt agaagaggta gaagattatg atttcttttt tttttactct attaacgcat 74641 ggaaatacgg ctttaccttc tcacataaat atagtttgtt taattaataa agccaatata 74701 aacatttgca tattcgactt cgtgcatgca gaaatgcggc agataaattc atttctgtct 74761 aatcttttga acagttttaa agtacaaata tattagtatt taacaggaaa actaaaaaaa 74821 tgtataataa gaaatgagta aagttatgag gctatcttgt gtttattata gtatataaag 74881 ctaccgaaaa ggttgttgta acaagtagct tagtaaacga aacccaaaat cttaccagaa 74941 acgtgctttc ttctggcttc ttcatggtcc atgataccag cagaggtggt caagatgacg 75001 taaccgaatt gtctggctgg caacaagttg gcagtccatt tttcaatgtc accaatctta 75061 acgttgaatc ttggggaaat aacaccacac ttgttcaatc taccgttcaa ttgaacaaca 75121 atcttaccag atctgtggtc atcgatgtat tcaaattcac caatgtaacc gtgcttttgc 75181 ataacttgca aaaacttgat aatgaccttg gaggatggtc tgattaaaac ttgacgctta 75241 ccggtctttt cagcgttgtt aatggcattc aaagcatcag ctaaaacgga agatctggtc 75301 atcttggata tgtatgttgg tcttgtttta taaaaaatac tagaactgaa aggccattaa 75361 aaaaccttac aatttaagaa ttgaatagtc gattaagatt atttagattg aaattgacta 75421 actgcaaacc catattcaag aattatttca catcttccag cgagtaaaca tgccgctggt 75481 aatcgcgcgt cctcaatatt tgagtttttc aaatagtgag gtgtggatgt atagaggaat 75541 tacacacttt taagtatgtg atgtatgggc gcacagtacc aatttaactt tttttttttt 75601 tcatttttta gcttgatttt caaaaaactt atgggcgttt taggctccgg ctcaaactac 75661 caccaccacg cggcaggccg aggcaaacag tacgccttgg cggggacgcc gaagcgactc 75721 cttctgttcc aagctcaatg gtccttgcgt ttacgctcgc gcgtgggcta actaacgcaa 75781 ttcggctttt gggctgtcga gaaccgagaa ttattcttcg ccttgataga tactttaaaa 75841 cttctactta atatactttc tacaattttt ggtacattca tattatactg aaaattcgaa 75901 aaagacaagc aaataaacac agatagatca acatggctgt atgttagaaa gatattataa 75961 atcccagtta gatgctgaac tgatcaatag caaattataa accacatcca tctaaatgac 76021 cttaccacct acaatttgga tttgaaatag aagcaatgtg taaaatatag ggaaaggatt 76081 aggagtgtta accatactaa aatttttctt atccgaaaca gaaatctaaa gtcgccacta 76141 cgcagattaa aatatggtca taaactgctt attctgagaa cttttggtgg tccagcgtgg 76201 tttatgtcag gtggtattgc cttggatccg tgaatgcatc acattgatga gtttgaacat 76261 tgttactaac attttttaca attgtacact tcgtatgtgc acgatatgtt tcccttttaa 76321 ttaggctcaa aagtctttca gaatcaagca aaaaatggct aaggctaaga agcaaaacag 76381 accattgcca caatggatca gattgagaac caacaacact atccgttaca acgctaagag 76441 aagaaactgg agaagaacca agatgaacat ctaagcgaag aacatattta tgcttcaaac 76501 tttttgtcat ttgtcttcca tccttccctt attctcaata tatatgtaat acgtcgtatt 76561 tgatatatat atatatatat atataatata atttaacggt tgttatctgc tacatctgta 76621 aaataaaaat aaaaatgctt gaagcggctg tacttaaaat aaactcatct aaggttttac 76681 atggtattac taccggactg caattacact ctttttcgtt attggattat ttatacaatg 76741 cggcccataa gcacgtgtgg gaaaaaagta tgtaaataaa acaaggtttt ttgttccatt 76801 tatcatataa aaaattttgg cttaggtcca aagtcgtctt cctggataat agcacctgca 76861 ttgcgtgtca tttctacata caggcattcc tcagtttgta agatttgatt tgccgtgggc 76921 cttctctcat aattgggctc tatcatccat cgtactattc tctcaagtga ttcaccatca 76981 ataagaaatt tcggtaccca tgcgggaatt ttagaacttt tatgcaaaat aagacgattc 77041 ttggtagcgg cagtattgac attattatta tcgttgccat tattcatatt agggttgttg 77101 atattactat tgttatgaac agtggaggtg ccagcgttgt tactattacc actgatattg 77161 tctctttcaa aatcaaataa atcatttgta tctactttcg taatgtctga aaataatgat 77221 tcagaatgaa tatctgtgga acttaatctt cctgcatccg ataaatcacc cgatctcaac 77281 ttatgccatg cgttgccatt gtcaggtaac acaacgttcg ctgcaatttc aacaatcatc 77341 agacccaggg aaaaaatatc tgccttgtaa tcgtacgtac aatcagaaat gatttctggt 77401 gcaatatatt ctctgtcacc ttcattttca aaacttttat cctccaacgg taaatgagta 77461 gccattccaa agtcacctag ttttaggtta ccttcaaatg tgatcatgac gtttgcgggt 77521 ttcaagtcca gatgcacaat gtgacaagaa tcatggatga atcgtaaagc caggcttaat 77581 tccacgatga ttttccaaat tctccaatct tccaaccttt ttttctttgc gataacttgc 77641 tcttgtaaaa atccatccaa attaccattt tcgcacaatt ctgtcataat atagtatgaa 77701 ttttgaaact tccaggaact gatgtaatcg atgatgtatt ccttcccttc ttgatccatt 77761 gtaatttggt ttgttacctc gtttagtatt ttaatttcca gtaatatgcg tttcaaggaa 77821 ttatatttgt ttggtttaat ggctttgatt gcatactttt tgtttgtttg ggcaaacgta 77881 acctggtaga ccgtggaaaa ctggccttta ccaatggaat gcacattcgt aaatttttcg 77941 aaaagatggg aatctggatt tgctgataac ttatttgaag agattagacg ccttttggaa 78001 tttaacggcg aagaatcggt ggaagatatg gaatgcgtct ctgcacttgt tgtgtttgtc 78061 acgatggcag aggagagtga caatggtctg ctttctctat gtgtttgaga tgttgcccca 78121 ataatagatt ttcgtcttgt tggagtggag atctcttcgt cagtgtcatt gtcatagcgt 78181 ccacgaaatt gataaggttg agggttcttt ctagttgaat gatgacttga tattatgatt 78241 ggaggtggga aattctcgtc cgtgccgtat aaatcatctt tgaattgttg taaactgttt 78301 gttagctctc tatttttcaa aataaccgaa ttccttgctc ttttgatttt tttgaacttg 78361 ttagaatgca atgtttgtgg agagctgttg gtaaccaagc tattagtggg agacaggatg 78421 tttgtctggt tattgtgacg atcatgtgca tgatattttg cctcgctcag tggggatgag 78481 tctatggttg gtacatggat ggaaggtaaa gctttcgaag acggagaatc tgaaaataaa 78541 aggtcttctt gtaaattatt gtcttcaaca aaatttaaag gggaaacact tagagaagac 78601 gatgcatttt tcgaactcga aaggtggaca tgcttatggt ctcttccctc cactaagggt 78661 gattttttca ctggtgtttc tggtatcctc aatttcgcag ggtataacga agtgtccata 78721 gacattttag atacgaggcc cgaagacgta aaggctgatt ggttaggttt agcgacgcta 78781 tatgaagagg atgaggatgt attttcagtg cgagcatcat ttttcggaaa ccatcgctgg 78841 ttccattgtt tgagagaaat aggactgttc gttttttccg cagatctttt tgtaatagga 78901 gtagtaacac tttcattttc atggaacgga gaccaccttt taatacgaga atccacgctt 78961 tcctcatcct tgccttcttc ctcctcttct tcctcttctt caattttccc aagaaatttg 79021 gagttagcct ctgacaaagc tgtattactt aatgacaggt tcaaggtccc cgtacttctt 79081 gtcaatttgt tgttcgaata tggataaaat ttcagtttat tggtcggggt gctaccccct 79141 atagcaaaat catcactctc gtcttcgccg gcctgtttgc caaacatctt cttccccata 79201 aactggaggt tctccgtgtc cagcatttcg aagtcctctt catcctcgtc caaagaactc 79261 atctgttctc gtgtgcgcct gtgtgtgttt acttttcccc agcactacgc aatcaaaaat 79321 agtaagacct gttcagtagt aatccttttt ttattggact aactgcgcaa gatgatgtgc 79381 aggatagtta acacacgcat acatacaaaa aagagcctct tggacaacct ttacttaata 79441 cacaggggca cgccaatgtt caactgtgtt gttgatttct tatccagcat tcttttactt 79501 ctctgcattt ttttcgcgtc gcgtcgcaaa ttgtgatggt taaaagaaaa atgaaaaaat 79561 atttttcgcg tcgttatcac ccggaggaat aaaaaaaaga aacatacaca tcacgtgacc 79621 acaagaatgt tagaaaggct taccagtact agagacgtta ataaattgcg aatagccccc 79681 tatctcccac atgttggcat ctgtgaggtg gaacctattt aaaggtgcca catttctttc 79741 cttagaggac gatggttgca agatcagcac aaatccatag tttgatgcat ggaaagcgaa 79801 gcactctaac agaagtaaga taataaacaa tctcacgatt ctactgattt aagtgcaact 79861 agctcttggg cttcttttgg ttgccaagtc ggaatagacg acagatgcat gtttcggtgc 79921 agagttcaga gagataagtg ccttctttta tctttttccc cgttcttgcg gatttttttt 79981 ttcactttct catcggcggg gaaaaaaaag tgtaacaact aaaggatcaa cacggcttta 80041 aagtgtttta tatatacgca gatatgaaaa aagcattttc acggttattg gaaattttta 80101 ttttacgact ggttcctagc acaacaagag gatatactaa tagttcaggt tacaatgctg 80161 attaggttaa agaagagaaa aatcctgcag gtcatcgtga gcgcagtagt gctaatttta 80221 tttttttgtt ctgtgcataa tgatgtgtct tctagttggt tatacggtaa aaagcttaga 80281 ttgccggttc taacaaggtc gaaccttaaa aacaattttt acacaacact ggtacaagcc 80341 atcgtggaaa acaagccggc agattcgtct ccggacttga gtaagttgca tggggcggaa 80401 gggtgtagct ttgcaaataa cgttgctgca cacgactctg gacacgatag tgacttaagt 80461 tacgagagct tgagtaaatg ctataatttg aataaaacag tacaagaaag cctacgagaa 80521 gtgcacagta agtttacaga caccttatca gggaaactga atttttccat cccacaaaga 80581 gaggcacttt tctcaggttc tgagggcatt gtcaccattg gaggtggaaa gtattctgtg 80641 ctcgcgtata cgatgatcaa aaagttgagg gacacgggta ctacattgcc tattgaagtc 80701 atcattccgc ctcaggacga aggcgaggat gatttttgta agaactggtt gccgaaattc 80761 aatggtaagt gcatttattt ctcagatatc gttccttcaa agccattaag cgatttaaaa 80821 ctcacgcact tccagttgaa agtctttggg ttgataattt ccagtttcaa gcgtattatc 80881 ttcttggacg cagataacta tgcggtgaaa aaccttgacc ttgcttttaa cactacatcc 80941 ttcaacgata ctggcctgat attgtggccc gatttttgga gacgtgtcac ccctcccgcc 81001 ttttacaaca ttataggatc tagcattaac atcggcaaaa gagtccgttt tgttagtgac 81061 gatatttccc ccgtgtcacg ttatgatcca tttgttagta actcaaacga ttacactcca 81121 aaggagagac aggagcattt cctgaaacat gttcccttac atgatctgga cggcacgatg 81181 ccagacttga gctctgaatc aggccagatg gtgattgata agattcgcca tttcaacact 81241 ctattactgg cgctatacta taatgtttat gggcctacct ggtattataa gatgatttct 81301 caaggcactg ccggtgaagg tgacaaagac actttcgtcg ctgctgccca tgccttgaat 81361 atgccatact atcaagtgag gactaacttt gaatttgatg gtttcttcta tcaaaaagat 81421 gattacaagg gtctcgcctt gctccagcat gattttgaac aagattacaa gcaataccaa 81481 aaggcgcagc agaaagttaa agccaacatt gaggaatttt ccaaactgga tccagattat 81541 actttggaca atggtttctt gaaaactttg atggttaatg atgacggttc tgatttggat 81601 atcatgttca ttcatgccag tttctacaag gcagatccat ggactcttta tcatgaaaac 81661 agatttatcg gtccaaatgg cgaacaagta cggggcttca ggaagccgca tcgctatgga 81721 atggattttg aattgttttt attcaatgat atgagggggt ccttctgtac cactccgaaa 81781 agccaagtta ttaaattcaa gtattttacc gataaagtta ataccccaga atgggatgca 81841 atgtgtgagt atttgaccaa tcatgttaat tatctggaga gcacacacaa agaagctatg 81901 ggggagaaaa actaatgaag tgattaacta taataattta ataataactc gccatccgac 81961 cttgtataat ataatgtagc atatatgtgc acggatatat atacatctta gaaaaaaatg 82021 aaaaaatgaa accaagaaaa aactaactga tggtgttcgg acaacgtttt agaatgaggg 82081 tatctaactt tcttctacca ttctctgtcc aaaaacctag aaagtaaagt ccagccaaac 82141 caagatgtgt tttccaacga cgaagacgct gcgcttggtg aacggtttaa tgtttctcca 82201 gtgctctcat ctgtaaatcg tgaccgcgat gacgaatcta tatctacgtc tgacaacctg 82261 tcgaattcaa gaggcatcga gtagtaattg aaaataaagt cacgctgggg gaaaaaagat 82321 ggtatatcgt caaatattct ttcatgatgg tatgtcaata attgccggcg agttttctcg 82381 cggtagcatg ttcttagaat tggatacaag tctcttgata gtttctgcac agcaattctt 82441 tgggcatttg taagtttctt taatttcgca gaggtataaa gttctctttc cttaaaggaa 82501 taaacgggaa atccatgatt gacaccgtcg cttgattgag ggacattttg atgcagctca 82561 ttaaataaat ggctgcccaa acaccactca tcgatccggt cagagttact agacgatcga 82621 atgttacgaa gagcgggcgc cggctgctct gagggcggag aatttttatt gctgtcactg 82681 gatatcgaca gtatagcaat ttcgtcagaa ggaacttcga aggcactact tgcagattcc 82741 agtgtctcat cgcgactaat ggcagtattt gtacattctg gagataaatc tgggttattg 82801 ataaccctta catcattgaa tgactttaat ctatggaagt ctagctcaaa ttcctcttct 82861 gagagttcca ggacttcaaa tagcgattct tcatcgtgaa tgccgttatt aattctgggt 82921 tgaatgcgag cagaccttga cccgcaatca acctggtaat tgttcacaga tgccattaat 82981 gagctgtact gaccaccaaa ttttagtatt ttaagccctg aatacaacct ttgctccttg 83041 tcgacattcg taagtatata gaaatctatc ccttcaaaag atttgtatta ttcgggatta 83101 cgctacagcc gcacgtagat cgtacgtgta taacgatgtt tatcttggtg aaagtatctt 83161 aacgcgaatg ctctagtgat ggcacaatag aatagtgtct tagcaccaca gagcgtgatt 83221 ttttaaagct ctatattagc aactacgata ggtgtttatt tagtttcttt gttgatcttc 83281 ctgtttccag tgttacggcc ttgtcaggtc aaaaatttta cccggatctc tagtaatgag 83341 taacttaaga atatcccatc tgattattgg tagttttact gaaccaagtt agagctaaat 83401 aaatatatac agccgatagt gcactggaac cttatcctaa tatctcaatg aaactaccgg 83461 tagcacagta cagtgcacca gatggtgtgg aaaaaagttt tgcaccaata cgcgatgacc 83521 ctcgatacat gaccacagag ggaaggacaa ctgggcccag tgaccatgtg ctaaacgctg 83581 gccaaatcga tagagacaaa ccttcagaac cggaacgcac gaaagatggc tcacaactga 83641 catacttagg ccagctgcgc acgcagctga cggggctaca ggacgatatt aacgagtttt 83701 tgacaggaag aatggaattg gcaaaaaata agaagaaagc cggcgcagac gagaagcgga 83761 tccaggaaga gattaaccag ctattagatg gtggtgacgg tgacgaagat gctgtttagg 83821 caacgatatg tagcgctaga gagtgtatat acaaacagaa aagagtctaa tgataaatga 83881 caaatatttc gttacaagtg ataattgttg aactaggaag agttgatata aaaaaataat 83941 aaacacacga tgggatacag ttaagaagga ttgatcgact cctaaatgat gcgaagaaag 84001 ccaattttca acttggaatc atcctgccgg tttgttgttg gtgttagctg tgttaggact 84061 cgttaaaatg gcaatcaaac caagaacgaa gggcaaaacg tactcctcaa gatcggtggg 84121 ttcgcagtgg ttcaacaggc ttggtttcaa gcagaacaag tacggaactt gtaaattttt 84181 gtcgataata acggcctttg tttttatcct ctatttcttc tccaatcgct tctatccaat 84241 ttctcgttcc gccggtgcat catattctcc atcccatggg ctgtatatta acgaaattcc 84301 tgcctccagc cggttgattt atccacatgt agaacatgtg cctgtgttaa aacaaatgac 84361 cgttaggggc ctgtatatta cgaggctaga agtggatggc agtaaaagat taattttgaa 84421 accagaagag aatgctttga cagatgaaga aaaaaagaag actactgatc aaattctatt 84481 agtgaagcac tcgttcttag accatggtaa attagtgtat cggaagagca atgatgcacc 84541 tgaagtggtc gtagtaaccc tgatagattt tgaaaactac gaattagaaa caattattca 84601 aattgttcaa aatagggttg attacgctca aaagcaccaa tatggtgtat acattcgttg 84661 gatacaggag tttttgcctg ttcttgaaaa tcagaatttg gctgaaagct acgaattcat 84721 taagccattg gtgataagag ccgccatgca tgctttccca actgccaagt atattcattt 84781 tgttgatcaa gatgctttat tgatgaatct cgatctttct ttacaaaaat acctgttaga 84841 tccaaagatt atggatttgg ctctattaaa gaacgtccct gttgtggcga attcaaacat 84901 caagacatac aatcattttg aatatagttc ggcaaagatt atcattccac atgatgcgga 84961 tggtaatatt gatgcgtcct catttgttat tgccaatgac ttttatggta aagctctgat 85021 agactacttg aatgatccgt tactgagaaa tttcccatgg gataataccg gtgataagtt 85081 gagtgctgct atcggtcata ttttacagtg gcatcctaca ttactgggta agacggcaat 85141 cgtcatacca aaagttttgg caagtcagta cgatgcatcc ttggatcaag aaggtgagtc 85201 tggaaacggt gcttctaatg gcgatgttta ccattataat gaaggggact tggctgcctc 85261 cttcaaggga tgtagatcaa gaggtacgtg tgctagtgaa ataggtcaca tgtaccagaa 85321 aatcaagaaa tcttagatgt gtgtaatctt gcaatttagt ttcaaacaag atccttgtat 85381 ttatataaac aaagatataa tttttaaaaa aaaattagaa aaagcaaata taattcaggt 85441 cccacttgga ataatggcac tgtattgatg cattttcctt atgcttagtg acgcgttttc 85501 gcgcgtcagt ttcaagtttt tcttggcttt ttttttttca ttttcgtaaa gggtcttaaa 85561 aggattaaaa aatgcagtat tgaaataaag aacaattacg aacggtgaag ctgctatttt 85621 ggttattata cccttccagg acagtacgcg caaactatta tggagatatt caaggaagaa 85681 gaagaagaag ctttttcggc gatagaaggt ataatatatg cctgtgaggt gtatgaccct 85741 gtaccccgtc atttacataa aagcaaaaca aagatcatca atgctgctaa attaattata 85801 gaaacgcatc tttcatatta tacaatactc aataacattt cagatataca agcctatctt 85861 tctacttggc ttagggatct tggaacgaca ggtccatacc aaacaattct ttcagaaagt 85921 atttctctca tgtttgaccg cactgtatct atcttcagga aatgtacgat agagggaggt 85981 tttccacatt tgatcgcacg tctttatctc agattgaaaa gctaccagaa gctcttaaac 86041 gatgcaggat taaagaattt tttttcaagc tacgattatg ctttcggggt tgcatacaac 86101 cttgtaaatt gctctgaata caggtatgac gaagttcatt acatatcgaa cggcacttac 86161 tcattagttg catcgatgaa gatagatcct gctgaagtca ttaaaaggga acattttagg 86221 cttacaattc cgaaatttaa catatctaat atattaattg aaatttttca tttgctcgat 86281 ggattagcat tttttaaggt gaaccctgat agtttatcta tatctacagc ttcagcagaa 86341 acaatctttc gcagtatctc cgaaggtaat catcaggtcc tagaattggg gagaagttta 86401 atgtttccat tgttgaggac tggagatttt gaaatctgtc gtattgacga cgcgggagct 86461 gtcataacat ttacagaagc gaaggatgta aaactagaaa taatcagtct ggatgaagtt 86521 tcctgggtaa tgcagtggaa atcttgtctt caaaattatg agagaagggc agcaaatgac 86581 agttcattta tcaaaacaca cctacaattt aagaaggcca acaatttcaa tgaagataat 86641 aatgggctag gactaattgt agacagaaat attccaacag atgattttac gctagcttct 86701 acaaaccgtc aaagtccccc gccttcaaat actggttgtt cattacacag gtctaaaccc 86761 ttgcatatcc ctttatcatc tgttattcgt gaagactttt atgatagctc tctaaatgag 86821 cgtatatcta aagacggaga tagcagttgt gaatccttca gtggcgccga aagtatctta 86881 tcagactacg attttcatga taatgaattt tttaacaacc agtcacctca ttatttttca 86941 gaacacatag acaataactc gagagaggtg gtaataacag atgaaaatac gataatatct 87001 ttggaaaata cccaagtaag tcggtggtca aattactcat ggcaaaaaat ttcaccgcat 87061 caattacagg tctctattat ccaactgcgc atgggaaact tcattgtggc ttatgattct 87121 gattataacc ttcatcagtt caaaattcgt ttgtgtgacg atataaaatg tatacaatcc 87181 acagagcaag acatacaaat acgtgtcccg ctcggcgcaa taatgtgcag cgtcactggt 87241 atcttgaata ttaggacgaa ggacgctgac aagttgcttc gggtattaag cttttatacc 87301 actgaccaca cggaagctgt atcgcactca aacaatcaag atgctactgc aagtccactt 87361 tcgtcagttt catcagcaat ggatctcaag cattcattac agaaatgttc ctctacaata 87421 atgccccaag agttgacgca ggacgtcatc ggttcaaaat cagacctaat cagtaatatt 87481 cgtcaaaaaa tataatcatg tttatttaca gaaattttcg aatatatgct tgtatatata 87541 tcatagaaaa gtagtaatag aacaacaatt gaatcaacca tattattgct taaaagcagc 87601 aatcgcagca gtatgaattt ttcttctgat gtctcttttg tcaacgtcat gagtatcttc 87661 aacctctccc cacttttcaa cttggaagat tgtttctaag gtggcggcac gtacaatatt 87721 atccatatca gttttcaagg cgggaattaa gttcgcagta tcttttttat tttctaataa 87781 tagcacgccg caaatgaagg actttgtggt taatacagtt ttttcaagaa ttgcaagatc 87841 ccatggtgat aagctgctca tatatttttt tgctgcattc ttaacgatat ccgactgctg 87901 attgcctcgt aacccatgga tgtcggcatc taaaatttgt agtcgaatat tagactcgga 87961 tgaaaagttg cgtaaaaact cttccattcc tttgatgatg ggtatatata actcattttg 88021 cgcattgcgt aatcttcctt caaactcatt cataggggaa aagaccaata aagtatcggt 88081 atctaaatat cttaacaact gattttttat aacatcactg ttgcctccaa tctttgcaac 88141 taattgaggg tcacagccag gctcatttgt catttgtaaa tctatgcatc ttgccactaa 88201 tgaagttagt ggcaaagagt gagttttgat ggaaagactg gatagggacg accactccag 88261 ttttaatagg tatgctaaga gagactttgc attatcaact ataattccat ttcctagagg 88321 agtttttata gtcctgccat ctaattgtag agcaatcttt cctttctcaa catccctatt 88381 tagtgacacc ttttcccaaa acttctgtga agttttgctc aatctatttg tttccgtagg 88441 agtgttattc tcaatcgtgt tgtctgtccc cagtggctgg gcatttaatg agtagaatcg 88501 gggcagtttc aatcttatgg aattcacaat gaagcatccc ttccttaatg atggcagcat 88561 tccgtattct cttttgtagg gtttcgtttg ccttcaagtg ttttgttctt atttagcctt 88621 ttcctttacc ttaatttttt tcttttctct gaagaaaatg aatgagttta aagatatagc 88681 aattaaaaag taacagtgaa gaaatttctc agatgagcag atgggaatta aagaactatc 88741 tacagagctc tttactaaat tgaatcaata atacatactt acaaacatgt cacagatagc 88801 acaagaaatg acagtgagct taagaaacgc caggacacaa ttggatatgg tcaatcagca 88861 gctagcatat ttggacagac aagaaaagct tgctgaattg acaaagaaag aactagagtc 88921 ttatccaacg gacaaagtat ggagatcttg cggtaaatcg tttatcttac aggataaatc 88981 caaatacgtt aatgatttat cacatgacga aactgttctt ctggatcaaa gaaaaacatt 89041 aaagataaag aagaactatt tagaaactac tgttgaaaaa acaatagaca atctaaaggc 89101 attgatgaag aattaaaaga aagcggcaat agcctttcct ttcttagccg gaaaacttac 89161 tacgggaaca agtttttttt attagtataa tgtagatata aaagcttaga gtttatataa 89221 atataataaa aggttagcac tgctgttgca aaaatatcga attgtaagcc agtaaactta 89281 tttaaacggc gctataaccg cctctttggg cggtacttct gcctaagatt ctcgaaacca 89341 cttccttgca gaattcaggt aaggaagtga gaaattgagt agaacgttga atgaactcag 89401 cacggaaatc ttgaaaagag cctcctctgg tattcaagaa tgatacaacc atcaggtata 89461 tcaatgtaaa cagtagagcg tataggaata accaagtgaa ccacgaagtc ccgcctgcct 89521 tcttagctgg ctttttcccc tcgctgtcac catccttacc attatcgccg tcgccatttt 89581 ttttgtcatc atctttgctc ttcaaacagc cagatggccc ttttagggtc aattggatac 89641 ttttatcggc ccatgtgtga ctagtcagct cgtcttgttt catattgtca ttacactgaa 89701 attctagttt tgcgtcaaaa gaattggcgc cccacgtagc gccttttagt gtcaatgtaa 89761 gcgcactctc agtttcctcg acattgaagc caatgttttt gtcaaaatct ataatttgag 89821 tggtgatagc atccttaccg ggcaagatga catctgttaa accacatagc atgtcatttt 89881 ttttacattc ttcaggaggt tctacgttat gctcttcgca aacgtttatc caccactttt 89941 caatagttgt gcttggcgga gtatcccttt ccgtagaagt tagtgagcta aattttccca 90001 cctgatactt tttcaataca tcatgcttct cgcaggacaa ggcctgtacc actgtaatta 90061 tactgatgaa gccacatatc caagtcttcg ataccatcgt gaaagctttc cttaccttta 90121 tctatcgcat cgattgaaga tctcagatat aaatctacag cagactaata tgccactaac 90181 ctcttgaaaa cccgtcgctt acgaaaaaga aggaagacgg aaaaaggacg gcatcctttt 90241 caatttgcac ctggacattc tcacccatac atggccttgt ttttttttta actgaaactt 90301 ttttggccgt ttttgaggat atgatatttc tatgtcggag aacaaaagta ggcgtgggaa 90361 gtgaagctct ttcgctcttt ctgtgatgat ctccttccag ctaggctcgg ttcgaccctg 90421 aggtctgccc ctagctcctt cctattccaa acggaatacc aaatgtccag cccgtgacaa 90481 tgcagcaggg tggctaattt ttcatccaga gtttgcagaa tgttggttct cacaaactca 90541 gagagaattg gcggatgatg ggtaactgtg agaggaagtg tctggatttg atcgtatttg 90601 ttaaattcat caacaccttt tatgcagagg tgtagtagtg taggtagccc ttagtaattg 90661 gtgtttatta ttgtctatat agaaatttct ttttagtgta gcttgtactc tttccctgca 90721 ttatttttgt tttattgact tttgtcttgg tgaatcaaaa aattaacgaa acgaacaaat 90781 ttaaaatggc aagatacggt gctacttcaa ccaacccagc taaatctgcg tcagctcgtg 90841 gttcttattt gcgtgtttct ttcaagaaca ccagggaaac tgctcaagcc attaatggtt 90901 gggaattgac taaggctcaa aaatacttgg accaagtttt ggaccaccaa agagccatcc 90961 cattcagaag atttaactcc tctattggta gaactgccca aggtaaggaa tttggtgtca 91021 ccaaggctag atggccagct aaatctgtta agttcgttca aggtttgttg caaaacgccg 91081 ctgccaatgc tgaagtatgt ttaaaatgaa aatatgaaaa ataagattga aaaataataa 91141 tgatgtgttg acgggagatg ataaagtatt agaatatgtt catatgtgtt gcatcctatt 91201 ttctgcatga atgcacgatt cgaaagagct aaaattaaca gttttccaaa tgaaagagaa 91261 aagaaataaa gaagaaatgg gacatgcaaa aaggaactat ggatacctat taagcgtata 91321 gcatagtgtt ttctaatctt attttttctt acactacgac tttaaaattt ttactaacaa 91381 tgaattacta ttaattttct ttttaaaaca ggctaagggt ctagatgcta ccaagttgta 91441 cgtttctcac atccaagtta accaagcacc aaagcaaaga agaagaactt acagagccca 91501 cggtagaatc aacaagtacg aatcttctcc atctcacatt gaattggttg ttaccgaaaa 91561 ggaagaagct gtcgccaagg ctgctgaaaa gaaggttgtc agattgactt ctagacaaag 91621 aggtagaatt gctgcccaaa aacgtatctc tgcttaaatg cttttttaat tttaaaatct 91681 tttaaagtga atatttgatt tatatactac tatatactaa tttgtttagg ccaatacaca 91741 gaatcaaaat caaactaaga acaacacaga acaagaaaaa taacttttga taaaggctct 91801 tttaaataaa aaaaatagaa aaaatagaaa ataacacaat tatagatata tatctacatg 91861 tacataacat gtctagtcga atctagagaa atgggataaa aatcagagag aagccaagtc 91921 aagtgacgca ccattaaaga aatgaaccta gaagaaagaa aataagcaaa aatatagagc 91981 gaaacaaaat agaaagtgtt actaatgaag aataattaca acaaaaacaa aaatgatctc 92041 catgtgtcat tgttatgccg accaatacct gtaaaattga ggtgcttcaa tagaaatggg 92101 tttgacatca ttctcgttag atatactttg gccattatgg ttttcacctg tttcaatatt 92161 aggtttgtta aatggattct ttccaatact taaagtttca ggtttcgata gcatactttt 92221 gaaatggtct atctgcgacc tgatttcctc cttctccgcc actgaactat tattgatatt 92281 gctgtcggat attaaattca agcatttgct taaaacgttt acaatcttgc tggagttttg 92341 gttgaagttc aatctctgaa ttagtaagtt ttcctgttgt ctttctaggg ttttcctttc 92401 tagctccata aatttttcta gtttctttaa atgatttaat ttagcgtcca atttttccat 92461 ttgaagtctt attagctcgt tagtcaaaaa attcatttgc ctttcctcgt tggtagcgaa 92521 aatatgactc ctataaccca atgatgatat ggcaatttct gaaccttctt taatatgttc 92581 aattggcttt tggtcagaga tttcctcttt ttgtgatttt attgattctg cggactgaat 92641 ggctctctgg gtcatcgact gtacagtctt cggattgacc aaacccacca agaatgctat 92701 tgttgataaa acggggtttt cgctcttcga aaatggcaag tgaggagcat atttcaaagg 92761 tcctaacccg ttgtcattat cacccttgcc attgccgtca ccgtataaaa atttatcttc 92821 aatgggcaat tgaaggaaac gtaagataca ctgttcaggc gacttattgc caacgttttt 92881 ggccactttg taccagtcag cgccgaattc ttgtattccc tttaatagct tttgcaaatc 92941 ttcttttgac caattttcat caatttgttc tagaattttg acttttttca gaggacgtga 93001 agtttcgcct tcttccaata gattggcatc accagtcatg cttgttgacg tacttacttc 93061 attgttcatt ttaccaccat tatcattttt gtcaccattt tcatcatcag tggtactggg 93121 ggggtgagtt atttcatcat attttctttt gctttctttc aaatatttat ataaagtact 93181 ctccgaatca ctagtgttca tcattttttt aagctttgcc atatccggca gttgtacaga 93241 tggtttgtaa ctttcgaatg ggaatagtcc tctgggggca tcatgccttg tggaatattg 93301 agacgttagt gggggttcga tgttcttagg taatagtttg gagtcaacct gatagtttat 93361 tagcccccat tttgttaaga atttatgcaa tctgaataat gcagcagcat caccagagac 93421 gtttctcctc gccgtagtga cactgaaata ttcgttgggg ttcagcctgt aagaatttac 93481 catgaagttt ctgtatctca tgtaaacttc aggtgtcttt gatggaatcc tattggtgaa 93541 aaattcaggt aacgattgaa cttcaatgga atgaattttt tctagattga accatttaga 93601 ataacttgga ataacaattt catgtgcttg cggtatctca aaagtttcgg gttctactct 93661 ggtgatagtg gttttctttg gattggcact tttggagtga tcgttcatga tttcacgttc 93721 ctgttcgttt ctctcttcgc cactatctac cttcttatct acactttccg tcttttctat 93781 gatatcctcc tgttcagctt tatgcgcatc tggaatttca gatggagtat tagcaaccga 93841 cgaagtgttg cctagttgtt tagactcact ctttgtgtct ccaaaaatgg aattatcagg 93901 actaatcatc ggttgatcgt catcctcatc atcttcttcc acttcatcca tttcctttgt 93961 gttctcatct ggctgacttt cttctttgac accttcaata acagtgttat tctctggttc 94021 ttcctctttt tgtattttga cgtcctccat gtttttaacg tcaccatttg aatcctgtat 94081 tgtgctgtct tccttaatag caggcttatt gttttcattg tctaccgggt tcgtaggtat 94141 actaggagtg tttgcctcat tgttcgaaac agaactctcg gtttcgccaa agagattatc 94201 actatcctca ttatcttggc caaagacgtt ctgggccctg ctttcttctg tagaaggtgt 94261 ttcctgggaa tctagcttat tcgcttgcat agtcggctgc tgctttgccg ttaccgttat 94321 cgcctcactt tctgcatcgc gtgtgttcgg aacagttgct tcatccttca gagactcatc 94381 ttgttgctgc gattcttcac cagcagtatc tgtattggca acccctgcca cagctgcatt 94441 agcgttgcta tcactattgt tgtcattgcc atgttggtcc acgtccacgg aagcgtttac 94501 cgtggacccc tcacccagtg tattctccat gcttgcaaac cgtatcacaa ttggtctctg 94561 aacgcgcctc gatgtaccaa tatatcgcgc cttgcatggc ctttacacat tcctcttgcg 94621 tatctgatat agtttgtttt cgtcttttcg ccaatggcct aaacgccaaa cgtccggcct 94681 cgttattcgt gatgcctact taatggctct taaatcgaat ttaaactagc tcaaaagtaa 94741 tcaattcaaa ctaaaataac atcattggcc atcctgaatt gttggatgcc atctaaactg 94801 cgtattgacc attattccat cgtaaccacg gcggttcaat ataatatcac ttttgacgat 94861 taggtgtttt atttacattt cttttttttt ttcctcgaaa aagatcttca aggataatac 94921 aggaatagaa caggagtctc aaagcattct tgaagccaga tttgctccag tttgatagtt 94981 ccaagaagcg ctaaaagtgg cagttcacac tttgttttga ttactaggaa tctactcttt 95041 cgctttttac ttccttctca gagaatcagc aactgtgaca tattatagat aatgcgttta 95101 caaagaaatt ccatcatatg tgctttggtg tttttagtct catttgtgct gggagatgtg 95161 aatattgttt cccccagctc caaggcaaca ttcagtccaa gtggtggtac tgtctctgtt 95221 cccgttgaat ggatggataa tggggcatat ccctcgttaa gcaagatttc aactttcacg 95281 ttcagtcttt gtactggtcc taataacaac attgactgtg tggccgtact tgccagtaaa 95341 attactccaa gtgagctaac acaagatgat aaagtttact cttacacagc tgagtttgct 95401 tcgaccttaa ctgggaacgg tcaatattac attcaagttt ttgcccaggt ggacggtcaa 95461 ggttacacta tccattatac accaagattc cagttgactt ccatgggcgg tgttacggct 95521 tatacatata gtgccacaac tgaacctact ccccagactt ctattcaaac aaccactaca 95581 aacaacgccc aagccactac tattgacagt cgttcattta ctgttccgta caccaagcag 95641 actggtacgt cgcgtttcgc tccaatgcaa atgcagccaa atactaaagt gaccgctacc 95701 acatggacaa ggaaatttgc cactagtgct gtgacatatt actctacctt tgggtcattg 95761 ccagagcaag caactacgat aactcctggc tggtcttata cgatatcatc gggagtaaac 95821 tacgctactc ctgcatctat gccttcagat aatggtggtt ggtacaaacc atccaagaga 95881 ttgtctttgt ctgcaaggaa aatcaacatg agaaaagtat gaaaaataga cggcttctac 95941 tatcatcatt acagtaaggg ttgaagtcag gaaaggttaa aaataaaata aatatcaaaa 96001 agtttttagc ggaaggcgtt aaggcagcaa gtacacattc atttatctat ctatacatct 96061 ataaacacaa ctacaatttt tttagaaatg gaatttatta tatgaaggga agacatatag 96121 aggcaacagt acataaaggt aagaataaaa gcgattttag ctagtatatt tctgggtatt 96181 tcttacatag tctctgtaaa gcaaccacac cgtttaagct taaatcttcg ttctccttga 96241 atttgcatag tacagcgtct agaatcaaaa atcctagctc gccgtcatca ttgttcctgc 96301 aaacaaactc ataccacgag tcgatctcaa atgttttatt catagataca cgaatattgt 96361 tcaacgtaat catttcaacc tcgctgccgt ttttcgatga tatggttggc gattgtaaaa 96421 tcaactgaga ttcagtgggt tgtgatttga tttgcgctat tatcctaaac acaggagcat 96481 tgacgttgga gatttctgtg gggtcaactc ttggtgtttc gctggccatt tttacttgtg 96541 ttactggtag acgatgttct acaagaatgg tgaagggtgt gttatattgc tctttattta 96601 aacacgaacg aaaaaaatat cgcgtattgc cacatttggc gcgtcaatat taaagaacga 96661 aggcattata tagggcgact tgtcatgatt ccaaccatgg catgggcggt ggatgcttct 96721 cagcagtggc ccattacgtt agtcaacgac tgttggctgt catctgttct tgttgggtgc 96781 ttgcagctgc atcgacaaac atggatggat gcctctacat atatatatat atttatgtaa 96841 tggacctctg aatattttac tatgtaactg actataggag ataccactgg tgctgtagta 96901 caatttagca cttgcaagcg ttgacacagt tgttgcgaag gcctctttct tgtagcactt 96961 aattggagta tgactgccat catgtaggga aattatgaaa gcataggatc aatcttgacg 97021 ttgcaaagaa gaagagactt gctgttccct attgatcact taccgttatt ggagttcata 97081 tggtactttt ttcataattt tacgagtaat ccctagtggt agttaatatt cagcaaataa 97141 aataccagtt tgagaccaaa ggtaagataa gagtttactg ataaagacaa agaattggga 97201 tgacctagtc caagggatta tagtaccttc gcgagtattg catataagct tttagcgata 97261 cacaaacaaa gcgacaccgg gatttgcata tcgcttgttc ctacgacgtt gtcagttcca 97321 taacctctga tttcccatac ggattttgaa aatcagctac gaatagatag tctttttcta 97381 ttttcagtaa atgtgtcatt gaaaaaagtt tctttagaac gacgcttttt gcaggctact 97441 agaaacaccc acttctagta gctttacgtg acgaattgaa ccgcgtgatc ttgtgcactg 97501 ttatcctaaa tgctcaatgc tcagaacatc ttcttgttat ctcagcctcg ccacccttat 97561 cttatcatag cggcctttta ttttcccctt tgggcaaaat acgatacagc cttccaaggt 97621 cgggcaagaa agtttatgac atataaaaga aacgggtacc ccaaatacgt ctcttcccat 97681 tgtaaaacta atcctgcatc atcacattaa ggaatcattc atctaacaat tacattatga 97741 tcgccttacc agtagagaag gcccctagaa agtccctatg gcaaaggcac agagccttta 97801 ttagtggaat agttgccctt attatcatcg gcaccttctt cctcacttcg ggtctccacc 97861 cagcaccacc tcatgaggca aagcgtccac accatggaaa aggtcccatg cactcaccca 97921 aatgtgagaa gattgaacca ttaagtccat cattcaaaca ttccgtcgac acaattcttc 97981 atgaccctgc ctttagaaac agctccattg agaaactgtc caatgctgtt agaatcccca 98041 ctgtagtcca agacaaaaac cccaaccccg cagatgatcc ggatttctat aagcattttt 98101 atgaactaca cgactatttt gagaagactt tccctaatat tcacaagcat ttgaaattgg 98161 agaaagtcaa tgagctgggt cttctataca catgggaagg ttctgatcct gatctaaaac 98221 cattattgtt aatggcccat caagatgttg tacctgtaaa caacgaaact ttatcatcct 98281 ggaagttccc tccattttct ggtcactatg atccagaaac agattttgtt tgggggcgtg 98341 gttctaacga ttgtaagaac ttgttaattg ccgagtttga agctatcgaa caactgttga 98401 tagatggatt caagcccaac agaactattg ttatgtcgct tggttttgat gaagaagcaa 98461 gcggcaccct cggtgctgcc agcttagcct catttcttca cgaaagatat ggtgatgatg 98521 gtatttacag tatcattgac gagggtgaag gtatcatgga agtcgacaag gatgtctttg 98581 ttgccactcc aatcaacgct gaaaaaggct atgtcgactt cgaagtcagt attctaggcc 98641 atggtggtca ttcctctgtc ccacctgatc ataccacaat cggtatcgct tcagaactga 98701 ttactgaatt tgaagccaac ccatttgact acgaatttga gtttgacaat ccaatctatg 98761 gattgttgac atgtgctgct gaacattcta aatctttaag taaggatgtg aagaagacaa 98821 ttttgggcgc accattctgt cctagaagga aggacaagct tgttgagtac atttccaacc 98881 aatcacattt gcgcagctta ataagaacaa cacaagctgt tgatatcatc aatggtggtg 98941 ttaaagctaa tgctctgccc gaaactacca gattcttgat caatcacaga attaatttac 99001 attcttctgt ggctgaagtc tttgaaagaa acatagaata tgcgaaaaag attgctgaga 99061 agtatggcta tggtttatct aagaacggtg acgattacat tatccctgaa accgagttag 99121 gtcacattga cattactctc ttgagagaat tggaaccagc accactttcg ccaagttcag 99181 gccctgtttg ggacattttg gcaggtacta ttcaagatgt ttttgaaaac ggtgttctac 99241 aaaacaacga agagttctat gtgactactg gtttattctc tggtaacacc gatactaaat 99301 actactggaa tttgtccaag aacatttata ggtttgttgg ctctatcatt gatattgatt 99361 tactgaagac attgcattcg gttaatgaac acgtggatgt cccaggtcat ttatctgcca 99421 ttgcctttgt ttacgagtat atcgttaatg ttaacgaata cgcttaagcg caatgattga 99481 atagtcaaag attttttttt tttaattttt tttttttaat tttttttttt tttcatagaa 99541 ctttttattt aaataaatca cgtctatata tgtatcagta taacgtaaaa aaaaaaacac 99601 cgtcagttaa acaaaacata aataaaaaaa aaaagaagtg tcaaatcaag tgtcaaatca 99661 aaatttaaat gatgatgata atatgaccat acaatgactt aaatcaaatc aaaaccactt 99721 gcgtaaaggc agtgaatatg gccaaaatat aataccatac accgttttgc atcttcgtta 99781 aagcaacacc attcgacttc gaggtggtcg aaggcgcagt agcagaaatg ctcatcaatt 99841 gagaagaata ggtttcgttt tctggaattg cagccaataa atcgttaaca gtatcagcag 99901 aaacagttcc attgaatgga gtggcatcag atatgaaaga aacgacattt ccactagaat 99961 cgaaaacaac accacctttc atcgttccag tagtatttct tgttatgtat ccgtaagatt 100021 ggataccagt acccaaatcc tcgatacctt ggaaagtgtg gaaagtagaa tagagatggt 100081 ttttctccgt accattcata gcttcaaaaa tatcgtattc cccacatcca ctagcccaac 100141 atgaacagtt ggcattggtt ggatattgag aagtccttgc aatgtgatcg tttagcaacc 100201 aaatagcagg caagtcatag tacccaatag agctgctatt tttctcagtt tcagtaggca 100261 tttcgaattc aaacaaaaac atctttgttg tacctccgta cccatagtaa gctggaatgc 100321 cactacggta aaccccacaa cccttatcat aacctgattt tggacatgag acattcgaat 100381 agattatgta ttcttgatct gaagaaatca aagtgccatc tgccaaaacg gtagcttcac 100441 tggcgctgcc agtaccgtta gaactagcgt aggacaaagc atttcctaaa caaggggaag 100501 cttcacctcc atgatttaga aaggtaacgt tatcagcggt tttggaactg gactcatagt 100561 aggcaagacg gttccaatca gaagaacttc tgctgttgtt gacggtaaat ccaggggatg 100621 tgtaaaaagc aaattgtttc aacttcaatg gtccacggaa atgaacggat aaatagtctg 100681 ctagtggagc gttcttacca ctaaaccata ctctgtcacc cacttcgcaa gtacacgatt 100741 cattgttggt gatatcttta aacttattca catctacgta ggagcctgta aaaccaacat 100801 tagtgaaatc caacttttgg tacgactgag gtccactggc agcgactgtg tgcaacataa 100861 acatgcacac ggaaaggact atactctgta acatttgtct tatttaagct tgtaatgttt 100921 gcacttgagt atgttctatt atggctgctt ccttcgataa ggattgtttc tcgaggattt 100981 tcaggtttat aaataaccta agctcggcaa aatagacaaa agaaaagggc ggagccaaga 101041 ctttgaaaaa aaaaaatgga aaaaggaacc cttgcagata cagcaaaaat gggaaatgga 101101 ggctgtggaa aagaaagagg ctgatatcat tttctgtctt tagatctacc taacggcttt 101161 tcttacatag gagaactaca aatattatga gtatagaatc gatgaggagg ccaagcaaag 101221 accgtaaatt ccagtcgcgg aaggtcttac gtaataaatc gtgcgactcc agcacatcgt 101281 gggctacctt cttcaaaaac gcgtaacgat attttttcaa ggtgtcattc tcgtcctcga 101341 cttgttccgt gttcacgttt aggaaagacg acggcatacc gtctttgctc tcgtaatatt 101401 cttcgctgtt gctatcactg aaattctgca tgacgcgaat ctcttggagg acttcttcct 101461 ttatgggtat caccgttctt ttagttatgg cttcatattc ataaaatcct gggtattcgt 101521 cttcttgcaa gtcgtggaat tccaattcat gtggttgcca atactgtaag aaccaccagg 101581 ctaaaagatt caccaaccag aaaacggggc acaagattcc aaaaacaaaa aaccttggca 101641 gccaaggttg gacaggcaca ctcattttac atgatttgca ttggcaacag tattttttca 101701 tccaagggtt ctcatcgttc tcgaagggcg cggctagatg ttttgtttta tgctcaatac 101761 ttgatgctaa agtagtcatg tttcttgtcg tcattctttg aatttttgta gtcctatgta 101821 caagcacaat ataaatgaca gactagtcaa cgacgctgac cctttatatg ttccccgtat 101881 attccttgtt ttcattgcag ttaacatgta aatttcccga tgcggtaatt acgtttcaaa 101941 gtcatttcaa cacttctatt gacagcaaaa aaataaagac acttgaaacg cacgattttt 102001 tcaagaataa tatctgtcga gaagatgtgt cacattacct atcattacag tgctactgat 102061 agcccactaa tgcggatatt taaatatatg caccaaaaat gtataaagaa ataaacggta 102121 aagacaaaaa aaattactta ttacaaatcg caattacaat taaagtacaa gacttccttt 102181 gggacagaaa acgtgaaaca agccccaaat atgcatgtct ggttaattat gatgatgttg 102241 aaggtggagg agaagacatc cttgttgatg ctgatgataa tgccaacgcc tttttttgct 102301 tcttcttgag gataatctta tccatgtatg aatttatgaa ttctttaact ttatgccttt 102361 ttcctttggt taagtcatca ggcggcgctc ttgaagaatc ttttttaagt tcctttgtag 102421 ttaggatttt cacgatgtct ttagcacatt gtttaatgtt ttcatgatca aattgtttac 102481 tttgtgggtt tttttttatt aagttgggta caaaagatgc aaagaattta ttccagttgt 102541 gctctagtct ttgggactgg gagaccgttt ttcttttcaa ccgcttagcc tcttttgctt 102601 ccactagttt tttggcctct tccttttgta actccttctg tttgttggcc tccgctataa 102661 tatcctccaa aacgcttttt ctttcattct caagctttag cttttgcttc aggctttcca 102721 attcttcttg tttggctctt tctagcgcaa ttctttcgta ttccagtctt ttttgtttct 102781 tcctctcata ttcttcgtca ctcagcttat gtttcttaga gtctaaagcg ccaggcgttt 102841 ttggtattcc actgctactc ggagaattta cttgtgtatt tgaccttgaa ctaaagacct 102901 tagatgatcc cgaaggtgga tagtgtagtt tcgttttctg ttctgcatta taatacaatg 102961 ggcgaccgtt ttcgtgaatg atctcccagc ctggaggtaa tctcaccctt ctcaaatcta 103021 tcattttgct ggctgcgacg tttatgtctt tcttcgttat ccttttatat gtttcaaatt 103081 tcgaccattt ctccaataac tcatcgcagt ttggctttaa aaatggaaac tttgcaggga 103141 gagtttttac tacattatca atttgtgacg actcaatacc gtttcgagtt gtctttggta 103201 attccaacaa aaaatctaaa attcccttta taaactttat atcatcttct tcagtctcgt 103261 ttccttttcc atctacctga ggttgttccg tgataaacaa tttaagcatt ttgctaaaac 103321 aggtgtaacc gtgtagtttg atagcctgat gacgaagaga gtcatcatcg atagtaaaaa 103381 gtctcttcaa gagtttggat gcaattatct tattatcttg ctgtagtaat acactcatga 103441 tcttcgtcac atccactggg ctgtcgatag gttggacttc caatgattga agaaattcaa 103501 tatttatgtt ctcgttttca ttctttatta ttggctcacc gcttaatttc tttaacttta 103561 gccatttttt ctccatggaa acagtcactc ccaaggcatc agcgatgttc tggggcaata 103621 aagatgccgc atctgtttga gtcttaccac cgagaaaccc aatacaattt ggctcctcac 103681 agtagcattt ctgagcttga gcaccataac gatccacatt ataatcaaaa gtgatttcct 103741 caccttttaa aatttttctt tgagcaaata ttcccatgcg tagcttatcc ttaacaaccc 103801 atttattaac atatgcattg gggctgcaag agtgattgca aaatctggcc aacgaaccct 103861 ttattgtggc gtcaatgaat tctccgttct gtaacatcat aaaataaaaa tgcttgaaat 103921 gacgttggtc atagtctatt aacctatctc taaattccat ctcctcgatc acctcacctt 103981 tgtactcgta aatgaactgg ttggcttcta tgtcctgttc ggctcttacg ccataacctt 104041 tatgctttgt tttaaatatg gctatcggag cgtactgctt cttttgaaat ctctgatttt 104101 gacaatcatt accacaagat gaacacaaat cgttgacaca ttctatcaac gtaagtctat 104161 tgatacagtc agaatcctcg tcacaggcat ggttgacgcc atctgagaat tcttcataac 104221 agtcacattc catgaaatca ttattcttaa atgttccgat cctcttgttc gcatatatac 104281 agtcatccaa gttttcaaat ttggtcaatg cttcctctgt gagatcaggc tcttgatcaa 104341 aaagcctttg aggtttatgg ccctcagcgt tgttattcag tatttctttt tcatcttccg 104401 acgcactcac actttggttc ttcgacatga tcacgtaaaa caacaaccag gaaaggagaa 104461 aggtttgaca gcacgactat gcagttttct atcacacgtt cgaaagcccc tttgaaaagc 104521 tgccaacgtg accttacgtt ctgataaata accaccaaat taccaataat tctaatagtt 104581 tcttggaatt tttcacatgt ttgcagtgaa taaaaaaaaa aaaacgttaa aggtgatatt 104641 gatcacgtga caaatctgta aaagtacgga tactgtcctt attactgcga tatacagtgt 104701 gaggtattct aagcggtata ttcaccgtcc tctacacata ttttaaatac tgatgaagtg 104761 acaagcaata tcattgagca ttcttttttc aatagtcgaa gtcagcttct tctcgtcggt 104821 tctaaacgaa acgccttgtt gaaaaagacc gataaataga ggaagcaacg gcaggaaata 104881 tatataaacg catgtcgaaa ctaatacttt atgatagatt gttcttctat cagttttcat 104941 tttaacttta aaaactcaac caacaggtat tggactgaca taggcacaat aaactcaaaa 105001 atattacgta gaaatggctt cagaaaaaga aattaggaga gagagattct tgaacgtttt 105061 ccctaaatta gtagaggaat tgaacgcatc gcttttggct tacggtatgc ctaaggaagc 105121 atgtgactgg tatgcccact cattgaacta caacactcca ggcggtaagc taaatagagg 105181 tttgtccgtt gtggacacgt atgctattct ctccaacaag accgttgaac aattggggca 105241 agaagaatac gaaaaggttg ccattctagg ttggtgcatt gagttgttgc aggcttactt 105301 cttggtcgcc gatgatatga tggacaagtc cattaccaga agaggccaac catgttggta 105361 caaggttcct gaagttgggg aaattgccat caatgacgca ttcatgttag aggctgctat 105421 ctacaagctt ttgaaatctc acttcagaaa cgaaaaatac tacatagata tcaccgaatt 105481 gttccatgag gtcaccttcc aaaccgaatt gggccaattg atggacttaa tcactgcacc 105541 tgaagacaaa gtcgacttga gtaagttctc cctaaagaag cactccttca tagttacttt 105601 caagactgct tactattctt tctacttgcc tgtcgcattg gccatgtacg ttgccggtat 105661 cacggatgaa aaggatttga aacaagccag agatgtcttg attccattgg gtgaatactt 105721 ccaaattcaa gatgactact tagactgctt cggtacccca gaacagatcg gtaagatcgg 105781 tacagatatc caagataaca aatgttcttg ggtaatcaac aaggcattgg aacttgcttc 105841 cgcagaacaa agaaagactt tagacgaaaa ttacggtaag aaggactcag tcgcagaagc 105901 caaatgcaaa aagattttca atgacttgaa aattgaacag ctataccacg aatatgaaga 105961 gtctattgcc aaggatttga aggccaaaat ttctcaggtc gatgagtctc gtggcttcaa 106021 agctgatgtc ttaactgcgt tcttgaacaa agtttacaag agaagcaaat agaactaacg 106081 ctaatcgata aaacattaga tttcaaacta gataaggacc atgtataaga actatatact 106141 tccaatataa tatagtataa gctttaagat agtatctctc gatctaccgt tccacgtgac 106201 tagtccaagg atttttttta agccaatgaa aatgaagaaa tgcgtgatcg gaaattacgg 106261 gtagtacgag aaggaaactt gagccacccc ccaaatttta ttcatataat aataggaaaa 106321 gcaacgacct catctctcga acattgttta cttgagcaag tccgattaag agtaagttgt 106381 cgtacgttaa atacaaataa tcaacaaaac actacacaaa aacttctacg ataatgggtc 106441 ctccaagcgg taaaacttac atgggatggt ggggtcacat gggtggtcca aagcaaaaag 106501 gtataacctc atatgctgtg tctccatatg ctcaaaagcc attacaaggt attttccata 106561 acgctgtatt caatagtttt agaagattta agtctcaatt tctatatgta ttaatacctg 106621 cgggaattta ttggtactgg tggaagaacg gtaacgagta taatgaattt ctgtacagca 106681 aagctggtag agaagagctg gaaagagtta atgtttaata ttgtttccat gcctctacat 106741 tacatcgatc ttttgatctt ctaaaaactt acatatatat tctgtttata aaacaagagc 106801 aaataacccc catatattta ttcagtcagt ctatttattt acttacagta tcagtaataa 106861 taaatactta agcatttttt gttttgtata tctttattta ctaaccttgg tatgtaagtg 106921 tctataaact acacagcatt ttgttttcct catccaggag ctttgtagta attgttcaat 106981 ggtgattctc ttcgtggggt cgacctggaa cgttctatat agtgcaattt tcctcaacct 107041 attcagttcg ctactaacat gtcttaattc ctcaaataga taaaactgtc catcatcttt 107101 aatttcactg agaaatgatt taaaaagaga atccttttca ggaatggcga ttttccaaag 107161 atactgtccc atgaccattg tacagtaaac aataccacaa ctccaacaat ctaccagacg 107221 cggatcgtat tctgcatccc ttataaattc ttcaggtgcc acatatggct ctgaacccat 107281 ggctccactc tggaagtgga cgtgtttctc ccaggcagtc tgaaaaactg aactagtacc 107341 aaaatcacaa atttttaaca acccattagg ttggaaaagg atattttcgg gtttcaaatc 107401 acagtgtgct ataccatgat catgcatgta ttgaacacca ttcaaaagct gtttcataaa 107461 acagtctgct tctaatgggt gcaacggact cccagaacct tctttaacag tttggatcaa 107521 tcttgaactc ccgttattcg attcatttga gatgttattc cttgttagca acgaatataa 107581 atcacctgaa gcacaaaatt ccatcacttc tacgaaggaa ttgctatatt ccattaggtc 107641 caaaattttc aaaatgtttg gggcattgaa gacatgtttt ggtggagtgg ttcttgaaac 107701 atttcctgct atcatcgcat ttgcctcaaa atgcggatgg ctcagtgagt gtccaataat 107761 gaactcagag gttaatctcg tgcaaaattt atcaatttgg tcacctggct tgggcttcag 107821 ctctttgacg gcaaagaata gtttttttcc attagagtag gtactgtatg gtaggacatc 107881 tttagcagtc ttgcaccttg cgcaaatttt gaccaccccg tatgcacctg caccgacgac 107941 cccaatagat tttccgtatt tttgtgaaca aggtttatga gatgtatcgt cattggttgt 108001 tcctgccttg ccctctgtgt catcagaatc ctcctgttta ttgctattgc ttctgccttc 108061 gccattgttg ccttttgtat tttcactttt aaggcccttt cgtatttttt ccgataatgc 108121 attgattagc ttcaactctt caacacctac agcagcgtta ggattcacga tttgcggaat 108181 atttttacca tcgtttttca tcaattcatc attattgcca tttttaaggt tactcgttct 108241 cgatttcttt aaagtctgcg atttgatgaa tctctgggat ggtattattg aaaatgcttt 108301 ttctagattg atttgttcgc cgttttcttc ttgttgctgc tgttgctgct gttgttggtt 108361 tccatcctta tgagatttga ataatccact taaagaaaac acagattttt gtttatgcat 108421 atttgcctca ctgtcattgt caccatcatc gccgctgttt acagaagcgt cagcatcctt 108481 ttcatcgcca ctatccacat ttttattgtt tgtaataatt ggcagcactc tcaaagaatg 108541 ttcgtggtat ccgttttcaa agactttgaa atgacctaaa tccaaaatac atttacattc 108601 gatttcttga aatttcggta agctggaagc actgatagag tctgagtgat ttcttcccct 108661 catgtatatt ctatttcctg taccattacc aacattgttg gtggcatttg aattcattcc 108721 accatttcca tttttcattg gtggtgacct tggtgtggac aaactgttct tcctacttct 108781 tgtgcgattg ctatgattac gtacgcccag actgtttctc cttctaagtt ttgattcttc 108841 gtcataatca agcatagcat caatagaaaa gttattttcc tgatccaaaa catggttggc 108901 attactattt gcagggtttg aagaacctgc gttttgtggg aagtttttca gccgttccct 108961 tggttgtctt tcaacctcat cgctaccaac tgtatagcgg tgatgaggca cataagcttc 109021 cttggaacgt acatgttttg cacgagcttt ctcttccttt ttattttgaa gatcctctct 109081 ctctaacaaa ttggcttcat cttcatcttt ttcacttatg aaagattctt gtgaaaacat 109141 ttcattttct gaattcaaag atggttccct actaggtgac aacgagagtt ttgcaatatt 109201 agggacgccc agtttgtgat gcttaggagc cgcttgtaga acagggctat gtacggggga 109261 tatagacggg gaagatacgt tgctagttat tattcttgct gtttgatgag aatgtgcttg 109321 gtcctgaccg ggacgagatg aaggagccgc agcattatta ctgcctgata tccctgaagg 109381 cttaaataga cccttaatgg attcggagag cgatctggcc ctcttcaaag atgtgtggcg 109441 tgaaagcttc tcatctccca ttgtttttat tttttcaaaa tttttttttt atttagcaag 109501 tttctctatc tcctttgtat tctaaaagta aatggatgga aagaatggat cttttcgtag 109561 actataatgc ttcctaaaat atacacgtat agaatggaga ttccgacttg tttggagcca 109621 ccaattgccc tttatttggt ttataccaag gggctcacgt aaaaaaaaaa tcgatatgca 109681 aaatccttca tttcatgatg caagctttcg aaagtggcgc ggcgagcaaa gtagaaaatc 109741 aaagacagaa gcgtagaata aaagcccttt taatggtagg aatacgcctc gataacatca 109801 tgtatgcaat ctacaagaac agtgaacgcc gttccatctc cgtagtaact atacaggggt 109861 tgaaatttcg ttttcgaagg atagttgtta tgtagaaaag agggaaaaaa atatgaaaaa 109921 aaaaaaatat agatacgaga ggaaaataca acaaaacatt agtcattaga agtcccggaa 109981 aagatcagca tatgggtctt caccttgaac accgtagttg atgtcttctt ccgggtactt 110041 atcgaactgt gaggtgtcac cttgtccctg ttgaatgggc ggttcatacg gcgtttctat 110101 gtttctagat aataattttt cccagacaac ttctttgaac caggggtggt ttttgacatc 110161 ttctgtacca ttttgtaaat tacctagtct ttgacttaag tctcttgtga tcaatctact 110221 caacaggtcc tttacatctt cgttgaaaaa tggtggaaat ctcaattcgg cattcaagat 110281 tttctcatag gttttcatcg tgttagagtc gtaaaatggc gtgtatcctg ctagcatttc 110341 gtaaatcaga ataccgaaac tccaccaatc gatagattta ttatatggtt tagtactaac 110401 gacctcgggt gctatgtagt cgggagtacc gcataatgta tatgtgacgt caggaacgta 110461 tttggcaaac ccgaaatctg ttatctttat atgcccgttt ttatcaagca agatattttc 110521 cggtttcaaa tccctataaa taatgtcctt gctatgcaag tactccaaag ctaaacaaac 110581 ttccgctgcg taaaatttag caactgggtt gggaaatctt tgggatttcc ttaacaaaga 110641 aaacaattct ccaccttcaa tataatccat aatcatgaaa atttgctgag catcttggaa 110701 agtcccccac attctaataa taaacggatg tgttacgata gaaagcatca atcgctcgtc 110761 gttggtatgc tccacctgtt tcaatcttac cacgatttcc tttttcaaaa ctttcatggc 110821 gtagtatctg ccattatgtc ttgatctaat caaatggacc ctaccaaaag aacccgtacc 110881 cagtgtcctt aatatctgaa agtcttgtaa actatacttc ccacttgtaa ctctcgcttg 110941 ggcaataaac tgtttatact gctcctcatt gtaataagtg acatgtggct gcttcggttt 111001 ttcttgggtt tctccaccct ctttttctac agacttactt tcgttaccgc tctctgtggc 111061 tgttgtttcc ctttcactag tctcaccttt ttgtgattcc tcaccttgtc tatcatctag 111121 agacttttga ccacctccat tttgttcttc agtcgacata cccaaaaaaa agattctttc 111181 acacaatcag ctataattca tgcactgctt aagctaagag aacactactt tctgtgctac 111241 ctttgaagcc gattgaaaat gcaagcaagc caaacaaaaa aaaaagtata gggtcagatt 111301 ccttagcttt atcaaattaa aactcttaga tggatacaat cgcagcttct atgatgtttc 111361 gcacctaaaa attctcacgt ttttctggcc agagatagta gatgaatatt tttcaagttt 111421 tcaagtaaag ggatacgata tcccccttga ttattatgtc aaacttttac cagatcccgc 111481 cttccctccc ccctaatagc gcgaaaaaaa agatcatcat gattacgtag aaaaaaccac 111541 aacaacacta tgttgaatca tgtcataagc aaagtcgtta ggacactggc tttgcaagaa 111601 cgaatagcag cacagcttcg aacaagtaac taaaaatatg tggtgtatac ggtatgtaaa 111661 tgtttttaag gcccgtccag cggagggttc ttgtaaattc ttaggaagaa tgtcaacaag 111721 atggcaacaa tacttgttga gaacggtata tacataaaca gactaggatt aacggagaca 111781 gtacttccat atagcttaag gaggatggga gggatgacaa gcataacaca ggaccttacc 111841 aaagccattg ctccgaacat ctcgcctgta tgtttcttag aggtgtactt tatgatacca 111901 gactgcaaag ttggtgaaca aaacgcgctc aatgcctgta aaagagcgaa tattatcatg 111961 gatgtgggag ttttctcgcc aaatcgtatc atgacaaaga gactcagtgt tataacaatc 112021 atagaaaact gtatgcaaaa gatgtctatc ttgtctatcg aatggttcaa gtgttgataa 112081 atcctcttta gcgtgtacag taatgtaggt gatacgacca gtaacacaac acctcttccg 112141 atacccagta tcgatatgaa ataacctagc tctactgcat gccatttgta ctcatatgta 112201 gaaaacaaaa tcaatgctgg catacacgat gtcgttccac agacaaatag tatatcgagt 112261 acaatgagta atattacggt atgccggggt actaaagacc ctgcactgtc gggcttcagc 112321 cataactttt ttactggagc gagcaggtcc attaacctca ttatttgaaa ttttccataa 112381 gtaacggatt ggtaatttct tgcatcgtca gaacccgatt gtgatcttag tttctctctc 112441 ctctttgtat aagttgattg tgaatgggcc atttgggttt catggcgcgg ttccaccatg 112501 attgtctcac atattataag cgccagtata acaaacgcta ttgatgtgta aataggaatg 112561 aacccgtttc catgagtcca cttcaccaga aaggacccaa acattgggcc tacgcccata 112621 gtggcatata tacaactcat cattattcct attgtcacca ttctgtgctc agttttcact 112681 atatctgaaa cgtaactatt tccattcgcc actagcgcaa acaagccacc gaatgatggt 112741 acgatacacg cagtaagaac aatagcccat ttgtgatact tcattttcga tgatagggta 112801 aagacgtgcg taagaagccc tatgaccctg atgccgctca tgtatttgaa aacacgcact 112861 cttcctattc tatcggataa ttctccccac ttaccagcca tgaaaatact gattgcccct 112921 gctatcatca tagtggatga agaaatgctg gaaactattg tctgtacagc cacggaatca 112981 taatgtccat tctcatctga aattccttcc gctaccttgt ccatcaccaa cggtattgta 113041 gcagtcatag aaatagactc cgcaatacag ataatcataa caaggccgta aaggcataat 113101 agttttctac gtccatgctc tccctcaacg cttttggcaa cactcaaaat actgggggag 113161 cgccggatag agtcatagct actgtcctga gctgtttcat tagtatccaa atttattcca 113221 gtactgtcat tttgactaat gatttcttcc aaggcgttga tcccagccgt ttccaataaa 113281 tagtccatct catctgaaga cattaaacga gttgtttcat cctcgtttga cattgttctg 113341 cgcctttgct tcgcacggtt tgaagatgta tacgtgaaat gcaagaacta gggtttgtat 113401 tccttataag tctattagac ttcttgcaga tcagcccttc atcttgttgg tttttaggaa 113461 tcccttaccc tttatttttt ttttttttga tttcgattaa gggcgggaaa tcatgataaa 113521 cttccacgga acaacaataa acgctcggcc aatgttagta agatacactg tacttacctg 113581 atgataatcc catagcactt tcattcactt ggaagccaaa ccagtttata agtactttta 113641 aattgccaag tgcacccttt ggtaattttt ttttactttt accattttct gtaagaattt 113701 tctatttatt tcagtagttt attgaatttc cataactaaa tatatattta agatattaat 113761 aattgagaca tgaaatgtac tgactagata cttttatata ttttacatta ttcattcaaa 113821 ttatttccat cctggcgtaa ggacgacggg tatatgctca ttaagaagag cgttcgatta 113881 tactttaccg tcacatcttt cggaaaaaat tttaatgacc tgcatctgtc tttcttgtaa 113941 gatgttcaat ttgtccatta aacttttatc aaattctagg tatgttttcc aaaccataat 114001 actttgcttt tgggttaaca tatcactgaa ctgcgtatct gctctcaggc gctgtaatga 114061 tacttgatgt attgtttctt taagtttgtt acattggtta ttaaacagct gcacgttaag 114121 cttcaatgtt tcaaggtcag ccactgcatc aaattccgga atctctggta tttccaaatc 114181 taagatctcg ggtgtaattc cacactgttc tagtaacggt ttgaattttg cacgattact 114241 ttctgcttgg gcaaaagttc caccttgttc gtgactctga gtggtcttcg gctttttaaa 114301 aagattgatt gattctaacg agtcattaat tgcatccatc ataaaataat ctttttctct 114361 tggtaaagat tggaacaatt cttctaaaga tatatcatct ttctttctcc ttttcatccc 114421 tttaggttct ttgatagata aattttctat gtcgattgag tcgctgtgat ttttatcacc 114481 tatttcatcc cgacgaaaca gcaagtcttt atttcgatcg tctacattgc ttatattgag 114541 tttttcaata atgtctctca aaatgttcca tccttcattg gcactagttg ttgcaggtat 114601 ctctttaatg ggagaaactg actttctaaa ctgattcttg cattcgaatt tacttcttgc 114661 gtaatgtcga tactcatgat tgtaaaaagg agattgcaaa tttgaatcat gggatccact 114721 agaaaaagta ctggtcttgg gcaatttaaa ttgtttgtgt cccgtttctt cttcgccatt 114781 ttcctctgga gagactctgc tttccctttt cggttcttta ttattttttt tttcttcatc 114841 aggactgcta gacttcgacg tcattccata atgttgctgc tgttgctgtt gttgctgctg 114901 ttgctgttgt tgttttcctg cttcttcttc ttcttcatga tcgcttagtg ctgatcccaa 114961 acatgaattt ggatcttcag agtaagattt atgtgtgtac gcatttttac ccaatatttc 115021 ccatatttct tggaactgag agttcgtatc cattttaccg gcatcagtca ttcttacttt 115081 tgaggctcca ttggtttcat ggaacaaaga atcaatatca ggacttccat gtttcctttc 115141 ctttttggat gaataatagt ggtttcgttg gtagcttttt aaattgaagg acttgaatat 115201 cggaacctta ctcttagagc ttgaggtcat ttttttgcct acaccgaaac cgtagggctg 115261 ttgctcataa ggtttatttt gcctatgata agcttctgat tgaccaagtg tgggactagc 115321 cccttgtgat tcctttgcct tggtcttgaa aatatgacag tttttcttcg gctggtaagt 115381 gtgtaaacct ttgattttca aatctcgatc atatcgaagt ttttgatctt catcagttaa 115441 aattgaatgt gcatgcacca cagctttgaa taattcctca gacttatcag attttgtttt 115501 atctgggtga agtaatctgg ccagttttag atatgattta tgtacttcgg aggaagtcgc 115561 atttgatgtc aagcctaata tggaataata ggttgttcta tctaattgtg gttctattac 115621 ctgtgacata agaatagtac agtgtacaat agcataaact gaagaagcac tttgctacag 115681 tctatattga acattccagg tctatttacg ctcatgcctc aaaaaaagtt taaaggcatc 115741 gcacggtatt gtattttcaa gatgtccgca ccgaatcggt attgtaaaag tttcacaata 115801 ttgaacatct agcacaatga tcaactgaat tgaggacaaa cagataattt tcgtgtgata 115861 ttatatttta ataggataaa ggtgaactac tacaaactat ttcaaaaaat aactatttag 115921 ctaatcacat aaaaaatact ccgatacggg gagtcgaacc ccggtctcca cggtgaaagc 115981 gtgatgtgat agccgttaca ctatatcgga ttataaacgg ttaatattca acacctaata 116041 gtactactta ccaaattaac aagaggatca tctttcccat atgataatag acaccggctc 116101 taaactcaac tgttctgtac tagttgtttt gatagaattt tttttacaaa tctgcccaaa 116161 gtacgttttc ctagtttcat gcctgtgcaa cgccgcagcg ctaacctgtg caggacagat 116221 atgtaaattg gaatcttaac agcaacagag actctctcaa aaccgatacc agaactcaac 116281 cgcacttcgt tatccataaa tgttgcctta gccgaatgca atacatccct tataaaatca 116341 atacaatgcg aaacttaaca caatgctagt cgctaaccac gacaaatttc ttgcacctcc 116401 aaatctgcct ttgtccctct cccacatctt aactatacca gaaatgcctc tctgttctgc 116461 aaaaaacctg tgttcctgct attagatgag gtaaattcaa aacattacat gccatatctt 116521 cttctagacg actacacctc taattacatc aacaaatttt aaacttatat cgtctagagt 116581 gatcctttcg ctagaaatgg taataactac tgccattgga atcatagttt acagaatatt 116641 gcgagtttgc tctatattag atatttataa acgctaggat ggaaccgagg gctgccacga 116701 tgcttaaaaa attacagtgc agcaactccg atgccattaa tctatcataa agtctggcgg 116761 cgtattcctt gcacaatttt catatcttcc catatgaata cctgttagtc cgtatcacca 116821 agtgtaaact gttctttaca atgagaacat ctagagtctt tctgatatgc gtaacttctg 116881 cctcattaat ttaaaaattt cttcatagta aatagcttat ttgcttggag cagatgatcg 116941 acatgtattt ttaggaacat aaactgccta aatataatag atcagcctaa aaataagaat 117001 gccaatcaac aaagttgtat ttcctatctt ccgatattcg cagtccacca ttcagacctc 117061 tggtgagata gtttgcctgc ttttgctccc ttccaaagtg ctgataaaaa cctccgtgat 117121 tttttgaata ctcccctgaa tgtctatttt aagtatatta taaaattagt ttaagttggt 117181 gcggataacg aaaacttgat gcaaggtaaa taaatcaagt atatcataga gttctttcat 117241 tcatatgcta tacacaaggt tgttacgtca caactcacaa ttcaccaagt tttcaggcac 117301 atcgcccaat cttggctcaa aacctttatt ttcgaagggt aatttgtaca ctagtctttt 117361 agtgacaaca ctgtatggga caggtctggc atgcctatat ctagaatcaa atagcttgaa 117421 taagtccaaa gagcaagaag atccccatgc catcgcagaa gacgacattg taaatatagt 117481 ccatgacgct cccaatagaa tattcaagcc agcacttgat acctatcaag agaaagagct 117541 tgacttacaa aagagtgacc tccataaagt acttcattct ttgacgtaca gtgatgtctc 117601 tcaattttcg attgtttggg ggtttctcat tcaactttcg agcctaatag gcaattccac 117661 cttaggcaaa aaatccattc tttataaggg aagtgtcgtt agtgttttag ggttcccacc 117721 gttgatttat atggcactta aacttaggat gaaacagctg gaaaaagctg gagtgcgctt 117781 tgagtaatgc agaaggcaac atctccgaaa ataaaaacga tgaagtaaat gaaaactcgt 117841 ttgtgaatac gtaaaattat aacgcgcccc atacatagta agacagactt acttttatac 117901 tattatttta gttatatttt tgaagtacaa tcaagacctg caagattata atgttggtga 117961 ttcaacaatc gacgagacca actgtttgta aatgaacggg attgcactgg cccccgatag 118021 actgatcgta aaggttatag aaagtgcccg acagacattg gtaaaacacg tcattatcac 118081 caatagctaa agtgccatgc ttcgttatcg accagccgcc agcgtaaata gcgcccgcct 118141 gtggaggtgg accatcaaat tggaactgtc tgtttgctac tatcgatcca attctaccac 118201 tggagtcaat aagaacacct ccttgtaacg ttattgccaa ggtgccagaa cttttacagg 118261 cttgcacctt gatcactttt tcattatttg gtttctttgt tggctctaac ttactcttgg 118321 aaagcacaga actactactg gctgaagaaa tagtaacttg cacttgacca tcatgaatct 118381 gagaaacagc agttgcggtt gaagttgctg tcgcagttac agttttactt ggaacagcaa 118441 ttgtggactt tgtgacaaca tttttagctg tagttatttg taattgacca tcgcctattt 118501 gtgacacaat atgtgacact actggaggca ccttctgcgt tgtaacttgt atttggccgt 118561 ctccaatttg cgaaactgga tgaggtaatt tttgtgtcgt tacttgcact tgaccgtcat 118621 taatttgtga aatgacgttt cttttgacct tactttcagt aacggtgaaa ggtataacag 118681 cgagaccgaa tgaggtccgg tactctgttg tgccaccatc cattttagag cttggagtta 118741 aagttgccca gggttcaggt ggagcgtacg cagttagcgc aatactactt aatagagatg 118801 ctagaaatgc tttcttgtaa tgcatattgg ggcggtgttc acttcttcag taagttgtat 118861 agaattaaaa aatcgagact aaacagaaat ttcgaaacaa gaagataagt atatgtatac 118921 aagttatttt actcttttaa ctgttttcgt ttccccactc tttcgcaaaa agaataattt 118981 tgtgagtcaa aacagtcgaa ttttcttgca caaaaagtcg atattctttt gtgactctgt 119041 gtaacttact ttctacagct tttgttactc cacttctctt atatataccc aatgattcac 119101 tcgtaatata tcagaggaac gttagaattt ctgtattttc tcaggaatcc tacaaaatta 119161 gaggtgaaat tgatcaggtt aaggagcaga agcccactat ataagtaaga tgatatcaag 119221 cctagttgga tgccttcagg aacggcaaat aggatatgtg agcttggcaa aggggttttg 119281 atagagtaac aatagatcct tgctagccaa tgcgacgttc ctctgtagtt tttaccacag 119341 ttttacttaa tttcgtgctt tgtccctttt tggcaaaaaa gtcggataat gtcttcacta 119401 tatttgtgtt ttcgtctttt aggaaaagcg tactttagta aactacaaat ttgagctgag 119461 ctaatttcgg attagtaaaa gatgcaagga acagtaaaaa ttaaaatagc gattgaccga 119521 aatcagtcca aaaattacta caacaagcaa atccaattaa aaacagtaaa atactttaag 119581 tgcatttacc gttacgaaca acatatgtcc tagttagtat agtagtctac taagtagcaa 119641 aaaagtagaa actctgtcac tataccagcc atcagttcat agtaaaacag taaaaattgt 119701 aaaaacaagc aaaaaaaaaa caagaaggaa caaatgcacc aaactgttga tctattctgc 119761 aaaaaaaagt atggtaaatt ttttccatta tcctggccgc taatccatat ggaggtgaac 119821 ttagaacttg cacaaggatg cgatgaatga taggctttgt gctataatta atgcaggcag 119881 gtccgccatg tccaacacgt tgctggccgc aaaacgagtc aatctcactg ctttgccacg 119941 ctcatttctc cccccttctg cccaattagg cgaccctcac aatgcacata cacatttccc 120001 acctctattg gaaggggccg taaatggtaa ttcttgggag ttattcatat taagtgatct 120061 tactatttcc tatttcggaa attattaaag acaaaaaagc tcattaatgg ctttccgtct 120121 gtagtgataa gtcgccaact cagcctaatt tttcatttct ttaccagatc aggaaaacta 120181 atagtacaaa tgagtgtttt ctcaagcgga acaccacatt ttgagctaaa tttagatttt 120241 ggtcaaaata agaaagatcc taaaaaagga atggttggtg aaaaatttat tagcttgaat 120301 ggtaggaatc ctcgagatat aaaaggaaca cttgaagtct aacgacaatc aatttcgatt 120361 atgtccttcc ttttacctca aagctcaaaa aaatatcaat aagaaactca tattcctttt 120421 ctaaccctag tacaataata ataatataat gcaatacaaa aagactttgg ttgcctctgc 120481 tttggccgct actacattgg ccgcctatgc tccatctgag ccttggtcca ctttgactcc 120541 aacagccact tacagcggtg gtgttaccga ctacgcttcc accttcggta ttgccgttca 120601 accaatctcc actacatcca gcgcatcatc tgcagccacc acagcctcat ctaaggccaa 120661 gagagctgct tcccaaattg gtgatggtca agtccaagct gctaccacta ctgcttctgt 120721 ctctaccaag agtaccgctg ccgccgtttc tcagatcggt gatggtcaaa tccaagctac 120781 tactaagact accgctgctg ctgtctctca aattggtgat ggtcaaattc aagctaccac 120841 caagactacc tctgctaaga ctaccgccgc tgccgtttct caaatcagtg atggtcaaat 120901 ccaagctacc accactactt tagccccaaa gagcaccgct gctgccgttt ctcaaatcgg 120961 tgatggtcaa gttcaagcta ccaccactac tttagcccca aagagcaccg ctgctgccgt 121021 ttctcaaatc ggtgatggtc aagttcaagc tactactaag actaccgctg ctgctgtctc 121081 tcaaattggt gatggtcaag ttcaagctac caccaagact actgctgccg ccgtttctca 121141 aatcggtgat ggtcaagttc aagctactac caagactacc gctgctgctg tctctcaaat 121201 cggtgatggt caagttcaag caactaccaa aaccactgcc gcagctgttt cccaaattac 121261 tgacggtcaa gttcaagcca ctacaaaaac cactcaagca gccagccaag taagcgatgg 121321 ccaagtccaa gctactactg ctacttccgc ttctgcagcc gctacctcca ctgacccagt 121381 cgatgctgtc tcctgtaaga cttctggtac cttagaaatg aacttaaagg gcggtatctt 121441 aactgacggt aagggtagaa ttggttctat tgttgctaac agacaattcc aatttgacgg 121501 tccaccacca caagctggtg ccatctacgc tgctggttgg tctataactc cagacggtaa 121561 cttggctatt ggtgacaatg atgtcttcta ccaatgtttg tccggtactt tctacaactt 121621 gtacgacgaa cacattggta gtcaatgtac tccagtccac ttggaagcta tcgatttgat 121681 agactgttaa gcagaaaact attagttctt ttatcctgat gactttttct catttgcatt 121741 gattagaaag gaaaaaaaga agtgtccttt tctactacta ctctagtcgc atccattcct 121801 ttgcatttat cttttctgcg gttggccaat ccattcttcc gagaatttgg ctagccatac 121861 ttgatgtttt cccattattg gttcgtttgg caatgctaat tttcttaatt gccccttata 121921 tactcttcca taaaatgttt tttttataac taattttctg tatatcatta tctaataatc 121981 ttataaaatg ttaaaaagac ttggaaagca acgagtgatc gtgaccacat aattgcctcg 122041 ctacacggca aaaataagcc agtcctaatg tgtatattaa aggctgcatg tggctacgtc 122101 tattaaaaaa aaaatattta tctaaataaa agaaaccttc ttttagagaa ccttaaaaat 122161 gtaatataca aatcattcat accaaaatct ttttacaaat cataatcttt ttctatttct 122221 tttcccttat aaaaggtaga acattagtac tttgatgtag ctatttaaca gtcgaccaaa 122281 gaaacagctt ccaaatgaat ggcactacat tgttcggcga cgttttgatc atacaagttg 122341 tagaaattgc cggatagaca ttggtagaaa acgtcactgt cacccaaagc caagtaacca 122401 tcttcagtaa tggaccaacc ggcagcgtag atggcgccgg cttgtggtgg tggaccgtca 122461 aattggaatt gtctgttagc aacaatagaa ccaattctac ccttggcatc agtcaaaaca 122521 ccgtccttca aggtcaattc taaggtacca gaattcttac atgagctatc tttcaaagat 122581 ggagtggcac aagaagatga tgtggcatta gtagatgttt tagatgcaga ggaagagatc 122641 ttttcggagc tggttggggt agcggtagta gtagcttggg cttgactatc ggtggcttga 122701 gcagtagcag cagaagtggc ttggacttga ccgtcaccaa tttgagagat aacgtctctc 122761 ttagcttttg aagaggtaat agcttgaaca gcaataccaa aggtggtagt gtattcggca 122821 gcaccacaag agatggagcc ggttggggtt aaggtggacc atggttcacc tggagtgtaa 122881 ccttcagcag aagcagtggc ggatagagca gcaacggagg cagctagggc gacgtttttg 122941 aattgcattt tagatgtaag tttagcgagt gaaatagttt tatgtgtctt gatttacaat 123001 tactactgcc aaaaagagaa ggttaagata gacccaccac aagatagatt ggctctcttt 123061 cccgaatact tatatactga ctgtttggag atgaaacctt cgagaatttt tcacccactg 123121 tcaacctatt tcttattttt gtttttgttt gtggacgttt agcttaaatc ggcgcgaatt 123181 tttttggcgc agtacacgct gacccgtttc ttttgggcga ccgtgtctcg accgtagcaa 123241 aaggggaaaa agaaaagctg gaagggctag gcgggatctg gcccgtggaa atcgtatgga 123301 atgcataggc ggcccggcca ggcaccacgg aaaaaagctg attgtcctct tttacgagcc 123361 gtggatttgc aggaagaagc aacgcacgca tggaaaacac gtgacctgaa agtcaccgga 123421 acaaattagc cacatcgacg tttcttttac tatacagctc gaacaagcta acttgaaatg 123481 ctacaaccat gttggtataa ttgtgtacag acacgtgcat ttttggtacg aagagggtta 123541 cccggctgcg agtttttttc attatgaact aattcaggga aataatcccg ttcgggaaat 123601 agataaacaa cgccaaacga aaaaaaatat atagtgcata tatgacgaga tttaattatc 123661 gccaataggt tctttcttag gcaaaattaa agtttactca atttctattt atacattaac 123721 tgctatttac gacgcattat atatattcag tcattgcgta gtatagacgt ggagaaacga 123781 aaaaaaaaaa aggaaaagca aaagcctcga aatacgggcc tcgattcccg aactactaga 123841 ggttgggaac ttccagggtc tgatgaattc tttgctgctt taccaggtca aaatattcta 123901 tttctatcaa actagaatgc gggtgttcat ccataattag acgcgttttt tgttcacccg 123961 cagccatatc ccccaaatat acttgctcga atgtagcttg tggtagacga agagttacat 124021 ctagataacg cttagtgtgc agctcctcta aaaactgctt aatgctagcg ttcaatggag 124081 tcatgcggcg ttgcgaaatt tcgtatctcc aatggtaaga taactggtca aaggcctttt 124141 ttaatttctg atcatgctca atgtcaacaa cgtcactccc gttgaggacc aagatttgct 124201 tggcgtatcc agttgcaata tggtcatctg tatccacgta tgcacttgtt gacgctaatc 124261 tttcacaagt ttgtaatgtt accttatact gttgcttttc atcgcggaag acgtttggat 124321 taaccacttc taaattatcc aagaaagttg tccatccgtc ccaattttta tttatcattc 124381 cgatgaaggt gccaaatggg cctactacac cggatccatc tcttccaaca acaactattc 124441 ccagtaaatc gtctgtgttt aatccatcca atatttgatg aacactcttt agaactctct 124501 tgcgatacag ttccccatca gcatgcgaca aattcaaaca tacaataagt tttagcggcg 124561 tatcactgtg caatcttttc cacggtagac gagaatcatg ggattgtgct gatataacat 124621 caggcggcgc tcctaaagcg cctattatat tcacatgaga gagttccttc actgtagaaa 124681 caatctcact taatggtagt gtctccagtg aagaattttc tagacaatac ttccatttgg 124741 gaagcaacca cttttcgcag ttttcgttga acctcaagta tatttcaggt atattagtgc 124801 tcttcaaact acaaagtagt acgtcctcat tgaacttgat tacctggtaa aactggtctc 124861 taggaatctt acccaggatc ttcatttctt caaaatcaaa caaaactaga aatttggaga 124921 ataatattac aaggttattg tctacccatt gttcgccatc atcagaatac attagtttgt 124981 caaacaagat caaactgcca aattcgctat ccttatccac atttgtttcg atatattgat 125041 caattttctt tttccattcc ttttcccttt cctctagttc ttcgtggtcc acatgattca 125101 catcttgcaa gacccctaaa tcatcactgg tccgcatttc ttgaaacttc acactgacca 125161 taacatgttc accacccgtt ttactaaacc acacttcagc agcactttcg tctatttcat 125221 catcacagtc cagtttttca tcatcactta aatcaaaagg gtctgtagtt gccattttat 125281 taacgaatgg tgaatttaaa aatgggctat caagatagct aacggcctca aattgattgc 125341 tattcgataa gcgtggtgtc ctgaacccat cacatgaaat atcagcagta cgaatgagct 125401 gctcctgtgg tgtaaactga ggaaattcac ctgtgaagct tctcgccgtt ttcaaatcaa 125461 tccattgctg ttgcatattg gatgacggac catcatcatg agcgcctgcg cccgttagaa 125521 gtttggatac catttcagga acaatgtctt tatcctttgg cttgctcact tcgccacata 125581 tcttacactc aggaaacttg ccttggaaat aaagagtttc aaatagcatc aaataacagt 125641 tatagtggct agtgtgtgaa cacgtagact ccacaacctt ttcaccggta aatgtggaac 125701 taatactttc ctcacagatt aaacatttct cacctatgta cctttttgga ctgaattgtg 125761 aattgcattt ttttatgttt ctttccaggc tgatcatgaa agttggtgaa tcttcttcgt 125821 aatatgaatc gccgtcaatg cgataatctt catccataac cgttaaattg atgtctgaca 125881 aagtatcaca catagttgta gaatcagaaa tcgactctcg gagtaaacta gtagttaaat 125941 ttgtagcttt gatgttgtat ttgttgctac ttgtgatatt tactggcgat tgtaaagcgc 126001 taagttgtcc tgttttcgaa aaaccagatg ctactgatcc cgctgttttc ttcaaacttg 126061 gtgggggaga tataggcttg gaaagattca gtggtttagg aatattgcct cttttggaca 126121 tcattaggcc aagatttgga gtaaattgac tctcttcaat atacccaaat gtgggcatct 126181 gttgcttctt aaattctggt gtctttctaa aaactttacc cgataaacct cttagaaatt 126241 tcttcggtgg tgatctttca gcgtcacgat ctccacttgg tggagtgtgt attttttttt 126301 caaacgaaac tcttgttggt gtcttcatta atagattgcc ttcttacgcc cacgaagctt 126361 tccagtggat ctatagactt tgtgtaaagg atggtcaaga aatataaaag taaatagaaa 126421 ttttttgaat agataagata atatacactc tcaagacaga gtgaacaaaa aggatagttt 126481 tattttcttt taataatttg aatatattat atactgtgaa ccaaggtacc ttcgcatttg 126541 aaacctttac gatgtcattt tattgcctat ttccttttta ggtattttcg gtgaaatggc 126601 tgcatgttga aaattgcatc gctgaaaaaa aaagatatgc aaacaaaaga aagttgcatt 126661 ctgaaacgac cgggtctctc ttgcccgcct aacaaaacca aagaggtaaa tgaaagtaaa 126721 cagatatttt tccttacttg gaaaaataaa gcaacaatga aggtgagttt tatagtcgct 126781 cctacagtga tgcaagtgca atgtcttttt tttttcatcc tgtaatgggt taaataactt 126841 caaaaaggca aatcatccat ctagttgtgg atcaatgtcc cattgaattt tagttacagc 126901 atgtagtctc tccaggatat cacctatagg tgtgaacaaa ccaaactgcc tctgttcacc 126961 atcgtatgaa tgcaacatac caacaagccc caaacctaga cgatcttcta acttggtcaa 127021 gatccatgcg cctgaatccc ccgcactagc aaataaagga gttggagatg caacgacaaa 127081 ctcgctactt tgtaactttc cgtcggccca ataaactaat tttgtagaat ttaactcgcc 127141 tgaagtgtat cccgtagaag cccctatttt aaatactttc atcccaggct tcattttaaa 127201 aatttttcgt ttcacatgta aattttgaaa tcttaatgtt ggatctggga atgattttaa 127261 gccattacct agggtattct gacatttgaa tgatgaatta actttgataa tagcaaaatc 127321 tgataatctg tgatctacga ttgctctctc gccccaaact acttgaccaa atttgtttga 127381 tttctgccag ttcaagtttt gatctattct ttgcacttcc tccaaaaatg ctgttttctc 127441 caccgaacca tcaggatacc tatctgattc tttcgttaaa actttcttgt aagaagtctg 127501 taaaacatta gaaggtacca tgacgtttgg ataatcttgc ttctcagata atacaacgtg 127561 ggcgcaagta atggcaaatg agcagcttgc aaattgagaa aattttttat cactaccagt 127621 ctgagggaat agataacccc ctaaagtacc tgtaatttta gcgcttgtct cagtggataa 127681 agacatagaa attggcaatt caagtggatt ctctgaaact gcatatgggg gggaaaactg 127741 aaatttagtt ggggctattg tatcgatagt tgctgcggta tgagacggaa tactgcctac 127801 tgctgatgca gcttttttaa tgtaatcttt cacacaatac atgtgtacat ctgggaacaa 127861 cgaataaaga acctttatca tttcatagtg ttcatgttgc aagttgggta agccaaacat 127921 tattgtaaga attgaactct ttggggttat acctctaagt ataggtgcta taaaagcacc 127981 ttcctggtca gagattattg aagaatccat tttggtcaac tcatctagaa tcatgcctaa 128041 tttatccata cttggtaagt tgcaatggct gccaatacaa aagactgata agcatggtaa 128101 aacgcccgat tctgatatca aatcgtcatc cgtaataagg tttagtttct tcaggaagaa 128161 gtaaaatctt cgtaacagta tcgacctaga attcgaaaat gcgtcggaaa ccaataaatt 128221 atccagaaaa tgtaatacaa ttttattaat ttttcgtaat gaagacgatt tttctaaact 128281 tatcctgtac ggtatcctgt ctcgtgttgt cggtaagaat tctttaaaat attcgatggc 128341 ttcaataacc gcttttgaaa tactgatgac atcctgatga atatcatcca ttatatcaac 128401 caaattttcc tctagctcag acaaactttt gtgaatgtac tccaaagtga tacttcttct 128461 ggaagtgaaa ctgttttctc tcgcattttc tgaagtggct aatgttgagg acgttgaaga 128521 gctgacgtct aaagtattct gcgtatcctg agattcctcc tccttaacag gactcaagaa 128581 gctcaccgct cttaatggtt tcccaacatc tttgaaaccc tgtaaatttt tactattctt 128641 agatccacta tgtccgctac tgtgactacg catttctgat gtggccatac tagaagaggc 128701 tcccgttccg taagtcattc ttcctctaga aaatatggat gacgattgta tggacgaacc 128761 aaaagtcgta gacgcatcat cattgtttgc attttcaggg ttcgtatcat gactgtttgg 128821 gtctattctt tcttcatttc cagatacgtt gctagacgac gtttctgctg cgttttgttc 128881 attgtctgca ggcaagtctg tattttcctt ttcttcgttc tttttcttgt ttaaaccaaa 128941 aaatctgacc atcggtatat cgagtttaca ccagtactat gtacatgcaa aaagaaagga 129001 ggatatctag tatgtttatt caacctttat tgtatattta cgttttctgt actgtataat 129061 ttcattttcg aatcttactt tttttttttt actcaaaaat acttccgccg cggcgttcta 129121 caatttcact taaaattagt ttgggtaata attacataca atgctgcaga cgtacataaa 129181 aaaccatcaa tgctacgttt cctgatcttt tcgtacataa aagattgtgc gtatcagcca 129241 caagtaagct tggacttaag atacacaaaa ataaaaagta aaatttaaaa tttgtcttcc 129301 aaaggagagt cattgagcag ttgatgaagt ttagttgagc tttgagaaag ctcacctact 129361 tggcttgtac ccttctcttt atatgtactc actgcaggga tgtttgcttt aattttggtg 129421 acctttgtgc cataggccct aggctccagc ttgatcaatg tgtgtagtgg gattgacatc 129481 caaggggatt cctcctgtgg aacgttcata aaatatgcat atatacaccg aagtacggct 129541 tgatgagtta taatgagaac attttcttgg cgctccaatt ccataatgac gggctctaaa 129601 cgaatcacta catctctgta tgattctcca ccacgatatc tgtactcgta tttgtcatta 129661 tcacgtgctt taaaatcttc aggatattct ttttcaattt cctcatacgt cattccgtca 129721 caaacgccag cgtctaattc atcaagtgct ttccattgca gtttcttata gggaagataa 129781 tttgccgttt gttgtgttct ttttaaggtg gaagtccaca cggtcaaatt tatttctcct 129841 gcgctctctt tcactaactg ctccaatttt ttagcgtact gaaagcctct ttcagacagt 129901 gatgaatccc cgccaatttt tttctctacg ttatagatcg attcgccgtg acgggagagc 129961 cagatatatt ttggtttagg acgaatattc ataacataaa atacaatcct actttccaaa 130021 tatgttctga tcttattaat tactacttct tcaataatat tgaccaactt aatgaacgtc 130081 atatccttat ctttttgggg gtccaaaggt tcataaaatc tttcatattg tctaattctt 130141 tccaaaaaat cagcttccgc cacatgaggt tcagagtttt cataatcagg agatgtgcta 130201 ccgatatcct tagcgttatt tataatcagt tcatgatcgt tactccagct ctctaaaaac 130261 atcggttgaa tattattctt ttcacatata tctttaagcc atttccttct tttacgtgta 130321 ctattagtag catcgaaaac tgccacagat ccgtcttctt tagtaaaaaa attaacaata 130381 tcttttatgg cattttgggc agccaattct ctgagtttaa aattatctgt attttcgaag 130441 ttaaaaaact cagcatccat tgggacattt ccactcacgt ctcttctgta atttcccaca 130501 ttaaaacact tggcttttat ggataaccac gataagtacc tgataatttt ttgggaaata 130561 aaagactttc ctctagctgg taggccaacc attatcacac atactttgat atcattatcg 130621 ttggaaatag tactgtaccc catgtttctt gtcttacttg attcggtttt tgagccccct 130681 ttcctttatt tcttaacaaa cttgcttggt gaatttaaga gcgaagggaa agcaaagatt 130741 atatattaaa ttcgtatcca ctggccaaaa tgatacttta cctgatgtaa atgtatgata 130801 agctatagct ctcttagtgg cgctttacat gtagatgtaa gttagggata agaatagatt 130861 tgtgagcgca ttggcgcgac ccattttttt aacacagaaa aaaagtaaaa aatagaaatt 130921 acccaattaa gtgtttttat agtaaacaat ccttgatatc ttagttgaaa ataaactcga 130981 attatgtaca agtttccttc cacttaatct atgatccttc tttaggtaaa tttttattag 131041 ctttatttgt gtagtttttt tttatcttgg gcatgtacga agagcaagta cgttatttaa 131101 ctatacatat atgactttga aacgatcgtc aacttctctt tgactttcaa tgtactcaca 131161 agtgcgtcga aaatggtgga ttgggatata cttcagttgg tgcagtaatt tactacctga 131221 agcagttgct acgactccgc gtattagcgt ggaagatccg ttcagagtat ttaattgaat 131281 atacgtacca tccgatccta tggcaacatt tgattcctta tctgtgatta cagagccatc 131341 gtcagcatta ctgcttgcct tcacattatt ttctccggtg atgtgcaaat cactgattga 131401 gttggtaatc atagaggcac tgttatcttc tagttttagc gattttaagt ttgttttgat 131461 tagttcgatc agaccattga tgtattttat cgatatatga gtttcggact catccccgtg 131521 aataaaatag tagaggcatc tatttaatat ttcgaccatt agctcacaac tctgttcgtt 131581 atccattata gaatccgcca cacggagaga cctttgtaga cattctaaca cccgtttacc 131641 atctctgtag aagttgtctg tgataccttc ttcctcacca atatttgaaa tttccgttgc 131701 ccaccagagg tgggagcata aataaacagc acgacattgg tcttgtttct ttaataattt 131761 ggatccatgg agtgtgcatc tgacaatcaa agaatcataa taagcttctt tgtagagtga 131821 tcttgtcttt tgtaaagact gagcaatata tattaaagcc tgtaactgag tctttgaatc 131881 acttagagac tcttcaaata ttgtgaaggc ctgtgagaaa aaatcatatg aaatttcgtt 131941 taattgcaat tgatcagcta gaatggcaca ttgtaaattc agtttcagaa tcagatctgt 132001 gcatgagttg ttgcaagaat taaagatatc attgatacaa cgagaaacaa atttaaacat 132061 ttgctttaaa agattggaat aatgggaaag taacgtcttg ttatcgggtc tttttttcaa 132121 aaggtactct tgtatcatac ggcatttcct catcagtttc caaaaatttg tgattattgc 132181 tggaaaagtg tatttaacat tgatgccacc tttaatgaac gaagatttaa taagaagtaa 132241 tatttccaat tgggcttcta agctaaattg aattttgttt ttcattgttt gtttccgaga 132301 agtagtgttc attatccaat gaatcaaatg tgccaacttt tcctgtattg ggtccagtat 132361 ccaggattct tcttcatcat gtcgattaaa aaacacttcg tctacatttg tatccgagga 132421 tgcaacattt gcgggcggtc cgcttcttga tattattaag ggctcacaga ttgaaagcag 132481 gcgctgaact tggagtttgt cctcaataac taaataagcg gaatgccctg gaggatgcag 132541 tttcgattct gaatcattat cggccatttc ttccacttct ctatccatta agatgtcaat 132601 aatttcattg acaacttttt tttgtagact aatgctctgc aaagccagga tgtttttgta 132661 agcctggcac tgggagatta attgaaagat aaaatgcttt ttcgaagtaa ctggtgagtt 132721 tggtggcgca gtggtcgatg aggttagctg aagtttacta ttctggaaag ataacagaac 132781 caaaaataaa tgctcggact ctaaagaaat atttttctga ccataatcct tagttttttg 132841 taagactaat tcaaagagtt tgttcaaatt atcaaaatta ttaggatacc atttcaaact 132901 taaaacaatc acactctcaa ctagaggaat aaactgttgt aatgatagat ctggtctttc 132961 atgattcaat acggtcaaat agtcccagaa cgtaccaaac acgtccatat ctaaataagc 133021 attcgtggag gtggcgtttg gatcgtcctc caactgtctt gtaacataat cgtttaatcg 133081 atcgaccaaa gtgagaacaa tcttgtttat cgaaacatca gggttcaaat gcaaagtagt 133141 ttgcagtaaa gtatccaagg ttttcaaatg gaactcgtct gcgaacactt ggcagatgac 133201 gtccaaaaga tattcttggg atactaaatc tctacattgt atgacttgtt ccaaaatggt 133261 gggaagaata tcttgcttat acatttggaa attatcatca ataatctgcg aaagacgtac 133321 tagttgagac cccactaaaa tttgcagctc ttttctttca cgtgttctgg tttccctctc 133381 acgaagtggc ccctggtgtt gtaatctcac ccacaacttg ttcatctcga tgaaattatt 133441 cataataaat tgagagttaa acgacggatc gtcctccgga agtaattctt tggttctctg 133501 ggataaataa tagcgtaaaa acaaacctct tattgggttt tgcacaccac gacacatctc 133561 aatcatatcc tttaagattt ccttcttggg cgcttcattg aaagtgagat agctggtccc 133621 aactgtgatc atcaagtaaa gcctgggtac cacgttaccg gtatattgaa ccaactcata 133681 aagatcagct aagtggtgat tttgaggatg gttttctatg aggtacgtag atagattagt 133741 caatgagtcg aaaataatga cataaagttc gtagtatttc ttcggcgata agtttggatt 133801 tctcaattcg gtcaacatta tggaagtatg ctgtaatgat tccattagtt tgtgttgaga 133861 tagacaccgg ttcattagtg cggttcgctg cttgataaca gcgatcgcat tttctggtga 133921 gtccgcatac gccattgtgt ttttcagctt cttctttctc gtcctcctcc ttttatcgtt 133981 atatattaac ttcactgggc cttgttgagt ggtcgcacat acaccacctt cttttttttt 134041 ttctctcttt tcttctcttt actgaggtgg cccttgaata aatacagcac tttctcgcat 134101 ctacctcaac tgaaaaaaaa aaaaaaaaat aaaaaacgcc cctttaagac gaagtgacaa 134161 agaggcaata gttcaaaaga aaaaaaaaaa atataaagac tgttgatagt tgaattttta 134221 taaacgttat gttaagtata tgtattgatg gaagggataa taggataatg gtgaatgtct 134281 tgttttttta taggtaggcg gaaaaagaaa aagagagtcg ttgaaatgag attacaacaa 134341 tctctcttcg aatcttagtt cgttttgaga aggcaatcca atcaacaatc ttaaaaaatt 134401 ttctaaggcg gttctttgct tgtttaagcc attcaccggg tgaaatcctg gtcttgttaa 134461 tggagctttt aaccagtaac tcaagaaggt taaaactgga taaaagttct cgaatttgcc 134521 agcatcttct ttaactgggt ccaccttctt ataggacact cttgtacaaa actcagtcat 134581 gactaaaaga tcgatgatca agggcgtagc cagtaaagaa tcttcgcaaa cattgtgaat 134641 ggaaatccgg ttatggccac ctaacatcaa ctcactgtaa tactcgtcca ttgccacttt 134701 tgagtccccg acgggcttca tatatttgat gacaatgcag tggtcaactt ttttacccag 134761 tttatcattg tacaagatat cattagacgc gatgatgtca tctatgacag aacttttgga 134821 aatctcctta gacctaaatt gttttggagc agataagtta taaccgtcat tattgcctaa 134881 atggttatag gatgcaatgg agaccggttt aatacctgca tccactaaga actgggccag 134941 aacagacttc aacttggttt gtcccgactt gagatcgtct cccgcaatga atgtaccctc 135001 atgctcagcc agctgaacca agccgggaac aaaagtattc tgcggtgaac cattaatata 135061 ggggacacct tccaagatag atgctgctgc aaagatcgtg gaaggagcaa tctcttcatg 135121 gtcattctta atagactgca agaggttttc catggtgtca ttaacaccag gagatacttc 135181 tacgtacctc tcagtatttg cagtccaaag aacgattact ttatcaaggg cgttttcttc 135241 tttgaaattc tggatatcgc gtctgatgcg ttgcagatgg gtccacttac ccctcgtggt 135301 tacgttgcct ttttcatcca aattgatgca gttattggct ctctcatctt gattagctgc 135361 aatgaaatca gggtagtaaa tggaaggaag aggcttcacc aaggacatct tcgccttcaa 135421 gcgttgttgc agatcatatt cgagaacttg acttctctgc atagcttcgt atagatctgc 135481 gttattgatg tcccaaccag agacgacaaa gtcgtttggg ctaaccatgg gcaacagaga 135541 gttaaaagga gcataaacgt cattcccctc cgcatcgata cccagtttca aggtagaaca 135601 ttgagtcatg gagccgaagt agtttggttg cttaacgcct tccttagttt gaaactccac 135661 attgtgctta ttcgccaata ccgaggccac taaagtggag ccattgttgc cacctaaccc 135721 aatgagcata attcctagtt tttccggctt tttcaagtca agtttgaaca cgtagtcttg 135781 aacagtgggc gttacatcga agcggccact agctgtcttc gtaactacag cattttcgta 135841 gctgtacttg gtgagcagct cgttgtcctt gtacgtgcac ttgtcggtaa ctactttaac 135901 ggaggtgatt ggagcaatat tatcttctgt cattgttact tctttttcac tggaaaaaaa 135961 agggaatgaa acagaataaa tcaaggataa aactaacatt aggaacccga caacagaaca 136021 agccaaaaaa aggtgacgaa agctccaatt tatatacgtc tcaaattaac attgccgcca 136081 acgcagaggt gcgctttctc tgctccatgt gaattaaata agttcaatat tctgggaaag 136141 aaggatgaag ataaaataga caatactttt cacatgccgc atttagccgc cgaagcgcat 136201 acttggcctc cgcatatttc acattcaaca ctttcgattc cgcatccaac cccggaacac 136261 cggcacgtat ttcataaaaa ggacgtgaag aacaaaagga acgaagaaaa aggcaataat 136321 ttactctatg tgttatttag aactacggtg ataaagagct cgttccgatc actaagtacg 136381 gccggaagag agctgttgtt tgttgtccat caagggcaca tcggcaccgg cctcatcgtc 136441 ttcatcatat gctggaggct gtgcttgaga ttcctctgca gggtgagctt ccaggtcacg 136501 gtctacggcg ggcgcagtcg catgtctgcg tgaaagatcg tacgaacgtt cactactcgt 136561 ttcatataca acgtagcaag cgtgaatgat tgctgggaag aataacagta ggaagagaag 136621 taagttcaat agtgtatccc tgttgaacat acccttacgc ttccagacgg ccactggggg 136681 aatgaaaacc gccaaaacca ttaacaacaa gtcgtccttg ttgatggaat agctcattcg 136741 atggtcatgg tcattaatat ggtctctgtc catttctaaa ttatatttgg ttgtttgctt 136801 tctgctgggt ttttattttt taacctagcc cctttcctgc agctggctca ttcgtgctgt 136861 actctctttc ctttatatac tagtgagacc ttttcccccg ttcccaaaaa gaaaaaaaaa 136921 aaaaaaaaaa gaaaacgagc cttcatcacg tgcattaaag aaatagtaat cccaacgcac 136981 tcatccgcta tatacatagc gaaaaactat atgcccactt cacaaatacg agtttgcatg 137041 tataatatat aagatttata aatgttgtag ggtgaatgta aacgttcagt aatataccgg 137101 tatatctatc aagatacgat caatgcaacg ctttactgca ctgcactaca ccccttttcc 137161 tctacttgtt tttcttagtt cctatttccc tctcaaaatg cacctgttca ccagagtatt 137221 ctttctcatt gcaagtatta ccctacttta tcgtcccaca caaagaggaa tatatataga 137281 ttataagcga attgtagatt tcgatggaga tctgatttcc gtgcaaaata tccaggacgt 137341 ctatacacag tgtttacaac tcagcttata ttcatatcat gccatttcaa gattattttc 137401 agaagaaaaa agcagcgttc attaacagaa acaataaaag taacgcagat gcttcagcgc 137461 tacgagatat taacgatatt aacataaatt tcgccgccaa gagcaaaaac tacgtgttcc 137521 cgctaacaaa gctccccgat gagctcatgc aagaagtatt ctctcatttg ccgcaaccag 137581 accgcttgca gctttgcctt gtgaacaaaa ggttgaataa gatcgctacc aaactgcttt 137641 atagaagaat atatttgaac gactcaaatg tagtgaagag tgacttcatg catctcgcaa 137701 ttaattggac cctactgaac ttgccgtctt cgttgaaaga agaggagtcc cgcgatatcg 137761 ccaactgcaa attgaaaaaa cttatagaaa cactgcaaaa taatattcac attactgaag 137821 tcatccagtg gataaggatc aactgggatt tggactctac cttgcaaagg tccattctca 137881 gcatcctttg caatcagggc aagtccttgc aaagactaga aaacgtcact gacccggctt 137941 gtaacgatat catctccaat ggtcactttt ccaggagcaa cgtctcaagt ttcgacatgg 138001 ctcctccaaa ttcattgcct gagatggttg ttcccgaaaa ttacattccg aatctcacca 138061 aatatctttc acagcgtatc tcttctcggc tttctcatat gactttattc atcgaccctt 138121 taaaactgtt caattatctt taccctttag atatcaagtt acaaatcatc gatttaaaat 138181 tgcattggag gagggagttt tacaataatg attattttgt taaaaagata cgacccggca 138241 atcctctgac taaactatcg gaggtttttg acaagaggac attgaaaatt cttaccatca 138301 tttcttggaa tgacactttg ttaaaacgcg agacagaaat gctgaaagat tttaaagaat 138361 ttgagaacct ggaagatttg tctttgattt ctattaagca ggatgttcat atcctcgtag 138421 atctttttag ttcgttaacc aatttgaaaa gactaaaaat ggatttctta gaggagtatg 138481 tacctgaacc cacaaatcct cacatatttc tctccattct tttagcttgc tccaaattgc 138541 aattcataga tctgagatac gacggtctta tcccacaaat catcaatatt caagaaaata 138601 agttccaact aaatcagcaa tgcaactgca caaactgtca aatagtattc agtgacattc 138661 tgaagggcaa aatattcatg ttccctgaag actactatat tcacgatctt caagacattg 138721 ctgcaaagga tatttttaaa atgatgaaat acctatcttt gttaccatac tctaaagctt 138781 gtgatgctta tccgagcgtt agaacacaac caatgaattt gactaatttt gtgaccaaga 138841 tgaaccgcaa ccttttggaa tatagaaatt ctaaatccca gttggtgccc aaaatcgtta 138901 ataacccaca tcaacactcc accgtgactt ccacatcaac cgctcatatg agcgagcccg 138961 aaatgataat aatcgatgac gatgatgatg atgatgaaat taatgcggcc attcctccaa 139021 gtagtgatga cacagcagct acaatttcca ctgacctgga acttcctcat gaatcattga 139081 ccaaaagaga tattattatg tgttatcacg ctcttatcca tcacttcaag tcgatttacg 139141 ttactttttt gaaaagtttt cctcatttga gattcttgat gttgaatgac attcccacaa 139201 tagttatgga ggagaataat gaacgtattt ttgaacccgt cttttatcat tatgattata 139261 agagtaatct gtatggatgg tcaaaggaat cgaacaagaa tctggagaac gacagcaaca 139321 acaacaataa taattctgat accattgcaa gaatagccac tgttatgtaa tcaactcccc 139381 ttcaaatata tatatttaat aatatatatt caacgcattt tttaagctag caggattcag 139441 attactggtc tacttcatat taaggaaata caagatccat tcggatgcta gaaaaaaatc 139501 aaccaactat tccaatgttg gtaagctggt ttgataaagt aaacacaaga tactacagta 139561 tacgatcact cagacatcct aggaaggtct ctaaagaaga gcggtcaccg agagtactaa 139621 cgatgggttc gtaagcgtac tcctaccgtg gaaactgcga atgttaagga accagtcttt 139681 catcaccgtg atcataaatt atatatatta tctgtctcct caaattaccc acatttgata 139741 atctcatgag aaaaaataaa ggctcagatc tgcatgtgtt gtataacact ggcaagaaaa 139801 gttcccgttt gcaaacacaa atgattaaaa aaaaatgtca cagaagcaac atcttttcaa 139861 aatcattcgc attaagagaa cgagataaaa tcccttgtcg tcatggtcga atcggacgag 139921 gaaagaagag acaccattat catcagggcc aatcaattct tcttttctgt ttaaaaaagt 139981 gtcatgaaat ttctcttgag attattcaaa cttgaatgta tcaaatggga aggagtgcaa 140041 tgctgaagtc gaaagaggag gattactctc attcttacta cattacagtc actgctgttt 140101 gttcttatgt aggggaattc ttattaaccg aatgtcgaga ttattataac cttacagaag 140161 gttgtccagt atttatacat tttgtttctg cccataaagc tctagaaaat gaaaaaaaat 140221 tttcttttca gcctgagaaa gttttttctt agggcagcgt gtggttattg ggtgttgcga 140281 aacttttttt ctcaaacatg aaattaaaga aatgaaaaat tttatcgatg agcattgaat 140341 agctcaagtt atagggtatt cggtatcata taggtctgtg atcgagtgag cagtgagcag 140401 ctaggattca ataaacggga ttaacaaaaa attgatatgt ccaagctttc gaaagattac 140461 gtatcagatt cagactctga tgatgaagtg atatcaaacg agttcagcat accagatggt 140521 ttcaagaaat gtaaacattt aaagaatttc cctctcaacg gtgataacaa aaaaaaagcg 140581 aaacagcaac aggtttggct gatcaaattc ccatcaaatg tggacatctc caagttaaaa 140641 tctctgcctg tagattttga atcctctaca accatgacaa ttgataaaca cgattataaa 140701 atcatggacg atacagatat tgagtcctcg ttaacacagg ataacctcag taatatgact 140761 ttattggttc cttcggaaag taaggaaagt cttaaaattg ctagcactgc caaggataat 140821 gcaccattac agtttgacaa ggtattttct gtcagcgaaa ccgctaaaat cccagctatt 140881 gattacagta aggtaagagt tccacgtaaa gatgttccaa aagtagaagg cttgaagttg 140941 gagcattttg ctactggtta tgatgccgaa gatttccatg tggctgagga agttaaagaa 141001 aataagaaag aaccaaagaa gcgttcacat cacgacgatg aagaggagtc tagtgaaaag 141061 aagaaaaaga agaaggagaa gagggagaag agggagaaga aggataaaaa ggataagaaa 141121 aagaaacata gagattgaat gcgtatgtgc gtataactgt gtgtaacata agataaaaat 141181 gtgcatttgt gtgtgtgtca gtgatttttt ttcgcattta catatataaa aaggcatttc 141241 tgctggtgga aactgatgaa tgttttgtgt gggcaatatt actatttagt tttgcatact 141301 taaatttgtg tatacgatta gaaatttcaa tatttcgggt gtaacacaaa cgattatttt 141361 tttcttgatt tagagtcgcc atatgaatat tattaacctg ctttttctgt gttctctctt 141421 atatgaggtt caatggtaag tgtgttttta actcgtgttc ttcttcatta atcatcttta 141481 atacacttcc aaggttgacc tgtaaatctt caaagattag tttatcctgg cacgtccgat 141541 ggatactccg tatagaaata tctaaggatc taataaattt gtattggtcc attattggtg 141601 tggacggttt cttcggtgac tccagcatta ttttgctttg tatactcaat tttacgatat 141661 caattaacca ttttttgacc aattttggtt cctcttcaac gcatttcgaa atagccctta 141721 aaatacgaac aagcaggatt tgattttggg tgaaagagaa accatcatct ttattgtggt 141781 tcaggaccgt taaatcaggc aatatatgtg acttttcata caaagattga taaattaaaa 141841 tcaaatcgtt attcctccaa tttgcgccta aaagcttaat gtaatgaatt atattttgac 141901 gaatattatc ttcagatacg ttagaagtta gacatctcca caaaagacgt cgcagaggaa 141961 acggtagatc actgtaatcg gacaaccaac gaggctcgta gtcttttctt atttgcacat 142021 cgtgcgttct ataatacaac aggatggata tcactactct ttggtattcg tcaaacaagg 142081 ctctgtgctc ccatacttta tcgaatttgt tgaacttttt tgagagcaaa atttctgtta 142141 tttgacgcac attagttaac ttgcccacat actgcaaaag cagcagccta tcatatagat 142201 cctcggacga tgaaccttgt agttccttcg aagaagaact tttgttatcc gttgcctggg 142261 taactattga gttcaaatgt gagaaaagca catcgtaatg aacagctact ttttgtttct 142321 tggactctac ttccggtaga tttgaattca gtattctcag gatgttctct atatggtgat 142381 tttgaagatt attttcttta gtgcgtgaac gattcaataa ggaaccttgt tcattaactt 142441 cagaagattc aaacaaaggc cccaacaact tcactggacc tttggtcaag tattttagag 142501 ttgatttcag ctcatcatct ttcgacttca atagtcgggt tgctaactga gaaaaagtcc 142561 tcctcataat caatgattcc tgtagataaa attgacaaaa ggcagcgcac gcactatttc 142621 cctttagcca gcacaattac ttatgcgtgt tgttgtttag ggttcgtaaa tctatattga 142681 aacgcaattt atattctact gttttctttt cgcacaaaca gaaaaccgct gtcacattat 142741 tgtatgactg ttgatatcgg accatcattt tcgacacttt cattgagggg aaaaatgttg 142801 gtgtcattac gctctctact catgtcttta tgtaagtata cgtttacaag attatttata 142861 tgctatgaca ctacgggttc tcaacttgca gcaaaacaag aagcagttag cggcacattt 142921 cggtgcaaaa acttatcagc agtttttgct gcctctcttt cactaatcta acttactatg 142981 tacggccgat agcagtatat tgtgcttttt actgtctttt attacttttg ctgttgctct 143041 tgctcttgac tgttcccatc tttgcttcgg aaatttcccc atgcgctgca ggacagaaac 143101 acaagcatga ttgaagcaat cgaattgtgc agtcgagttc aaaattggca gagaagaaaa 143161 gaggtggaaa ttgcaacacg aatcaccgct ttaccacgca aagatatctg gattcttgat 143221 atcaatcttt ttcaaatata ttttatttat ttatcaaaag ggcaagaaag aaaaaacgat 143281 tgataataaa aatggataat cagcaggaaa gtatatctga agatatcacc ggtgatctgg 143341 ccgctgctgt gagaaagtca tggtccgagt cacaagataa tccattactg ttaaatttta 143401 ataattctcc cataggtact cccactgata ggtactcccc tgaaccagca acgatgatgg 143461 aaggaaatgc aatgaatctt tcatcacttg cgagagggtc gacacagcag cagcaaaggc 143521 tttatggatc ttctcaaaca cgcgaaaaat ctgatcaaca gcagcaggat tatcagctgt 143581 tcaaacatca ttattctttg ggacaggaga cgagagagtc tgtttcagat atccttaacg 143641 atttgactct aggatctccg gaaccaagcg aaagggcatc accaataagg caaccatcgg 143701 tggatgttcc acctttaact acaaggcgta gttctataca ggacgttcag tggataagac 143761 atttactgaa cccaagaagt tcgttttccg gcgcatcttc caatgaacca accaactctc 143821 ctggggattt tcttaatcag agcagggctt ggataacaat actgcacgat tcatcggcag 143881 aatctttaca ggctgtcatc gtattggccg agtcattgaa gaatgtcaat tctcagtata 143941 atctctgggt attgcattcc agtgaagtca acgcctttca attggcccag gtaggaatca 144001 agacgctgat aatagatgaa tatatcaatt tattcatgaa tttcggcact ggctcgggat 144061 ttagcgcaag ttcgcaatcg accgaaacca agggcgaatt gaattttaag tggtgcaagc 144121 tatttctttt tttttcgtta attgatcgat tcgaattgat ttgctattta tcccctacat 144181 gcctggtact gcaaaatatt gatgagcttc tagagagcac tgaagtatct gacgagattg 144241 ataacgaaac ttgtgtattg ttatcgaata aggtaaatta tataaatgaa gatctcgtta 144301 gcgtgaacca agaccaatct tccgctgaaa attatgatga cgatcctcaa attattatac 144361 tgaagccgaa cagggcagta gcaatgtgca ttaaggaata ctttactatt tacgggaacg 144421 attttgaagg tgaaagtaaa aggtcgatgt ttcatcaaat gaacgattta cagattatga 144481 aagcattgtt tggcgataaa tggagttata tagatagcgt tggatactgt gctgttccca 144541 tagctagcgt gccagcgaat agattgaatt ataagataat cgaatttaaa atcctgaaac 144601 cttgggaaag acaaaactac attgctgccg gtcaacatcg agaatctatt atgaacaagt 144661 ggctagatct ttggcgagac tttttgaacc aagcaaacta aataagaata gtactgcttt 144721 tccgcaattc ttcaatattc attaaaggcg gtccggtacc ctcttcatag ttaatcccat 144781 catacttata atgtgtttca ttaaaatgca gttataataa caaaaaatta tatttttttt 144841 tgctgaaaca tgccggtaca ccgtatttgt aatcacttcc ttttgtatac taccacatag 144901 tcattatcct tctttttaat tccttttttt ttggtttcct ttatcatcac tatatctgaa 144961 agttcaaggt tattttagca cttctacatt ctcgggtgtg gctagaattg ggcggaatga 145021 aaaaaaaaaa ctatgtccat cgctttacta attagtgatc gcaccaagaa aaacgagctg 145081 tacattgcaa ttgtacctct tttttttttc ctacttagaa tcccaatcgt aattaattca 145141 ctaaattaac atccttaaaa tgaaattcga caatgacagt gagaagcagg ttttcgataa 145201 gcttaaaaaa gcgattcctg gtattatcaa ggaaaaatgt gcaggatacg atgaattgta 145261 tggttacaag ttgaatcctg aaggtcttac acaagaggag gttgataaat actatgacga 145321 aaaaatcgcc gatcgtctaa cctacaaact ttgcaaagcc tatcaatttg aatatagcac 145381 cattgtacag aacctgatcg atattttgaa ttggaggagg gaattcaacc cattgagttg 145441 tgcctacaag gaagtccata atacagaatt gcaaaacgtt ggtattttga cattcgatgc 145501 aaacggcgac gcaaataaaa aggctgtcac ttggaactta tacggccaac tggtcaaaaa 145561 aaaagaattg tttcaaaatg tggataagtt tgtacgctac agaatcgggc tcatggaaaa 145621 gggtttgagc ttattagatt tcaccagctc cgacaacaac tatatgaccc aagtccacga 145681 ttataaaggc gtctccgtgt ggcgaatgga ttctgacatt aaaaactgta gcaagacggt 145741 cattggaatc tttcaaaaat actatccaga actgttatat gcaaagtatt ttgttaatgt 145801 ccccaccgtt ttcggctggg tttacgattt aatcaaaaag ttcgttgacg aaaccaccag 145861 aaagaagttc gtggtattaa ccgacggcag caagttgggt caatacttga aggattgccc 145921 atatgaaggg tatggcggga aagataagaa gaacaatctg accaagcaaa atgtcacaaa 145981 tgtccatcca acagaatacg gcctttacat tttacaaaaa caaatcatcg aggacgttga 146041 gtgatttgtt ggcatgatct aataatagtc tcttatataa accctataat aatttcttat 146101 ttttgcctta tattcaggta aatcaccatc taactgtatt atctctcacg tatcttcact 146161 tatatggctc agaaaacacc gtacgaaacg aaggggctgc gaaaatgttt ctagaaggta 146221 atggcaataa tagggataca gatcgatcag atccgcctat ataaaagaca acgcaccgaa 146281 ggtgaacaag atcgcagata aaggtattta caagggaaaa aagtcagcaa aaacaagaga 146341 taagataaca agaagaagat gttaaggagg gaaacttcaa caatatacag gacacacaaa 146401 aaaagcaaca gtagtatact caggagccag cgggaccaga ctagagtgga ttccttggta 146461 gaggagtctc ccatgggcga tttcgggatc aataaccagc ctacacagcc tggcgtgata 146521 tactactttg tagagctgac taatttaggc atacaggaaa acacaagcag taataataac 146581 aacaacaata atcatggtga cgatgaaaac ggcagtcgat acggccacgg cagcagtctg 146641 ggtggagacg ttcactctcg ccgttgttca tgaactccag cattataaag catatctaac 146701 aataccattc gggttatact gaatagccca cgcacgggtt cggggttgta acgattatat 146761 gcatttcata acatgccact gtcagtggcg ccacggaagg atagcgggac tttatcaaat 146821 cattaatttc tgtgcataaa gtgtatagta tattcatata gatatgtata tatatcattg 146881 aatacagaaa tcttcgggtg tatacaacga acattcatcg gacgcctttt ttactgctat 146941 tgttcaacaa agtgggtaac ccggcattct tgcgccaaag tttccatttt tatgccaaat 147001 ccagaggata aaagcactat tctcatcaaa agatggaaaa gctgtgaaag agtcaagttc 147061 agaagaaagc gttaagaaaa atagagtaca cgggagcgtt atgtcagccg atcattcgag 147121 agatccatgt cctatagtca tactaaatga tttcggtggt gcttttgcca tgggtgccat 147181 tggtggtgtt gtttggcatg ggattaaagg ttttagaaat tcgccattag gtgagcgtgg 147241 ttcaggagct atgagcgcca ttaaagcgcg tgctcccgta ctgggtggta attttggtgt 147301 gtggggtggt ttattttcga cttttgattg cgctgtgaag gccgttagaa agagagagga 147361 cccatggaat gctatcattg cagggttttt cactggtggc gctttagctg taagaggtgg 147421 ttggaggcat acaaggaaca gttcgatcac gtgtgcttgt ttgttgggtg tgattgaagg 147481 tgtgggacta atgtttcaaa gatatgctgc ttggcaagcc aaacctatgg ctcctccttt 147541 gcccgaagca ccttcctctc aacctctgca agcttaggca tgtagacatt atatgagcca 147601 ttttttcatc gttgttggaa gtacccttat tcggcatgtt ttttgttaca taaatgacgt 147661 atcgcactag cctcctttac gtttttactt tatttcagcc ttttatttca agattaccaa 147721 ccatttctct caaccatgta catattatat attgaaaaag taccatactt catctctgaa 147781 gagaaaatat caacaagcca aaagctagtg cagaaacttt ataatgttac tttattaatt 147841 gtaatgacta tacgtataag gaaaattaag aaaaggcaaa attcatattt atttagtata 147901 tcattatggc accaagccgt aataaaatga aatgggtagt taagaaaagt cagacaaaat 147961 aacgatttat tcttcgacaa tgtgaagttt attgaacgcg cttgttggcc cttcttgaac 148021 agaatgagta acagcaaaat tattggagat gtcgccagat gtattctcct tccttttact 148081 gatagcacca atgtcgacgc tatcagcacc accagtggca gagctaggat tatagacata 148141 gttgtggcct gcattgttac tagagtcgtt cgcacttcca tattcacttt gctggccttt 148201 tgcatcgtca tgtttttctg aaggacccgg taaagacgat cctggaggaa accactcacc 148261 tgtaaactcc tgctttgtta tgaaggggtg tagcatagct tgttgtggtg tccatctttc 148321 taacgggttc aaatttagca caccgcctaa aaagtggatc aaacactccc tattctgcat 148381 ttcttggtcg ataagttctt gggagttctg tatgctttta ggatacctgt agtttctaat 148441 aatatctggt aactttctcc acttaaaata ttgtttactg ggcttttcca ctatattgta 148501 ttctctgcaa aactcttcaa tagttttcat acgatgcttt tgtgtagaag aagaactttc 148561 ttctggtgcc aatttcttca taaattttcc agagttttta cccatatcta tcatccacga 148621 tggaggatat ccaagcgtgt ctattattct tgttaattgg ttatattcag aagcgcctgg 148681 gaagatcggt atacccaaaa ataattcagc aacaatacaa cctaacgacc acatgtcaat 148741 actggttgaa tacggtatac ccagtataat ttcaggagca cgataaaacc tggactggat 148801 gtatgtataa acggttcttg cctcttcgca agatgagcca aaatcaataa ttttcaattc 148861 cggcttatca ggtgcgcaga gcaagatatt ctctggcttc agatcgcaat gaatcagttt 148921 gctttccttc aaaacgcata acgaatccag tatttgagtg gtgaatgttc tgataagttg 148981 tatagagagc ccatgaaatt tgttttgttt taataattcg tacaaattat tgcttagtaa 149041 ttcaaacact aaacataagt ggttcttgtg gacaaaggag tcatacatcc ttaaaaaatg 149101 atgtttatta gtagggtcta tcttttgatt cagtagctct aaaattttag cctccgttat 149161 actttgagtc aaatattctg tcctcgattt aaccactttt acagccaata tctctttcgt 149221 cagcaaattt tgacatttga ccacttgacc aaatgtacct tgacccaaaa tgtctagcac 149281 aaggtacttt ctgttctgct ctacacccaa aacgtcattt acataaagaa tatagtcact 149341 gtttatgttg tcgaatccgt tgttacattt cccttcactg ggcttcgtaa gtactctctt 149401 ggggtttttg gacgtttggt aggtaaattc tggagaacat aaagaatatg tggtaatcag 149461 gcttttcgtg acactgacta ggggagatat cgtcttggaa ttgagcgacg cacgtctaaa 149521 ctttggagta gcatttaaga caggttgaag atcgttttta gagttgcaaa gttgcatctg 149581 aggaatggac aatttctgac cttgtacttc atctcttcgt aactgcttga aagggggttg 149641 tagtggggga cttgtactag gaggatatgc gctaagcctc ctgtaaggtg acatgactgg 149701 tatggagttt gttccttgat tagtatttga atttagggaa gaaaaattgg acgaataatt 149761 agttgcagcc agactctgcc ttctttggaa atcttgacga tcataaaggg agggaacaaa 149821 tctggatcca aattgggaag gatggatagc gccctgctgg tatacttgct gttgttgttg 149881 ttgatagcca gaaggatact ggccactgct atttcctgcc aaactcgtat tagagctggt 149941 gtaagcggga taactatcgt actggaaagg atttggggca ggtgccctgg ctggaggtac 150001 aacgagacta gatttacgtc gtctgtacgc atctagactt tcgttactgt ttaagtcatc 150061 gtattgaggg ggatacacca ggttttgttg agaattagtt actttttcct cattccaagg 150121 gttaacaaag caaaattgag aattctgttg ttgttgttgt tgctgctgct gctgctgctg 150181 gtgatgattc tgatgctgct gctgtggaga cctttgagag ccttgattta cgtacgatgg 150241 attccatata cctctcccca tatggctatt gtctgggctt gctctacccg agcccatact 150301 agcatcactg tgggtcacaa gggtcgggct caaggagtta ttcatgttgc tattggagct 150361 ggacgagtcg ttattattgg atgagttcat gattgctcaa attagcatgt gaaaaaaaga 150421 taacgaaatt atgttccctt gcacaatggc tgttgctctt caccaaaatt cttctttcga 150481 tatattccca aatctaatag tgagaaattt gtgtaatacc cccagtaatg gcccaccaat 150541 tgtttcctta tatctgttta gcattgcgac tcattcattg ttcagcccag aaggggtaaa 150601 tctgaggagg gggcattgct tgcaatggtt cagaaggggc ggttagggtt aataaagcca 150661 tcgcgctatt ttgatatttt tattaggcct tttatatttt ttttagtttt tttctccaaa 150721 tcctaaatcc tttttaggtg tcatttacgt gcaacgcgac aatagtgata ttgtcattct 150781 tcaaactttt tgcaaggtag ctattaaaca tacctacaca catacgtaca tgcttaacgg 150841 tgagacaaaa gtaaagaaag agacttgaat gggttgctgc atcttaataa gttgagtttg 150901 agggcgaaag tacacaaata ttcatccgta ttgaaaatat atatataaga atatagaaaa 150961 atgaatgttt ctacatcaac ctttcaaaca agacggagaa gattgaagaa agtggaggaa 151021 gaagaaaatg cagctactct acaactgggc caggaattcc agctgaaaca gataaatcat 151081 cagggtgaag aggaggaatt gattgccttg aacctaagtg aagccaggtt agtaatcaaa 151141 gaagctcttg tagaacgtag gagagcattt aaaagatcgc aaaaaaaaca caagaagaag 151201 catttgaagc acgaaaacgc caatgatgaa actacggcag tagaggatga agatgatgat 151261 ctggatgaag atgacgtcaa cgctgatgat gatgatttta tgcattctga aactagggag 151321 aaggagttgg agtctatcga cgttctgtta gaacagacaa cgggaggaaa taataaagat 151381 ttgaaaaata ccatgcagta tttaacaaat ttctcccgat ttagagacca agaaaccgtc 151441 ggggcagtta tacagcttct gaaaagcact gggttacatc cttttgaagt ggcgcaacta 151501 ggttctttgg cctgtgacac agctgatgaa gcaaagactt taattccaag cttaaacaat 151561 aaaatatcag acgatgagtt ggaaaggata ctaaaggaat tgtcaaacct agaaacactc 151621 tattaataac tgtatgtata cgtgtgtgta actagtaatg aattttcacc ctgtggaagt 151681 taggcctatt taacaggaaa aaggacagga ttttaaatct cgtcttgctc ttcttttaag 151741 aaatatttgc cgctaccgtt tttccaccat ctcatcaaac aactatgtgg ggttatatct 151801 atgacacttt catcatcgct tttgcatcta cacctctgat cgagcctaac agcgtaagat 151861 gctggacagg tgccaaacgg tgagtgaaaa tagccaagtt cgtcaaaatg aatgatttcg 151921 tcaggtctca gcagtaggga gacaccaatt gaatgtacag gtgcgtcacc ccacctttcg 151981 tagtaaaatc cgcccttggc atctaaagtt tcaaaaaaat gcttatattc gtcacttctg 152041 aagaaattca agtcgccaat ctcaaaattc gaccaaaaat ggcacaaatt gtagtcagag 152101 tttgcttcaa caacgggata atgcttacca actagccctg aatcggtcaa aaatgcatag 152161 gcactgtcct ctttacgtaa aatggtctct tcgctggcca ctaaatactc ctctaccgcg 152221 tcccataagg ttggtatggt ttcttcatat tcatataatg atatgacaaa tccgtatttt 152281 ttgcccttca atctcataac tctgaacggg tcatatggga aatcgcaata atacttgaca 152341 ttgggttcca ccctaaagta gtaatcatag ttgtccagta ttgactgccg gaaaaaaaaa 152401 ccagaattaa accgacacat atttctatat gacttggatc ccccatataa aacaccctca 152461 tcctccatga ctcgaagtct ttcttcaaaa agtgtatcgt taatccattg cggccgattc 152521 caatcttctg gtggtattaa agcatattgg gtcttcccac tcgccattga tgttgtagct 152581 tcaatgaagt cttgatcgaa aggaacgtca tttagaaaag tccaatcata atgatacttg 152641 ttgttaaatc tgtcctctaa tgatctcatt gaatccaatg ccccttctaa ttctgaattt 152701 ctcaccagca ttaaaattgt tgcattttct cgtaggtgaa aagaatcaga atcattctgt 152761 ctggtataat ttaaagtgta gtcgtcgtag ctattgcggg aaagttttac tttaggaaaa 152821 tagtttcttc ttcgacttgt atcatattgt tcttttactc tttgggaaag agcagtatac 152881 gtactgtcaa tcttttggta ttttcgtatg aggaataact ctttgccaaa aatatagatc 152941 ataaaggtcc atattggtaa gaatatgcca acgatgtata gcgagcctcc ttttgccatt 153001 ttaacaattt ctgatgataa acttctttaa ttttgatagc gacttccaag cattagattt 153061 ggagatgata tgaataagca gtgacagatt atttctgcag atgaaaaata aagaggcgta 153121 gtactttgtc tttaactttc ctttattaaa aaaatgtata gaaaatttcc aaagcgacca 153181 gtaaaacagc tagttactct tcacacacaa agaaaagaag aaaatgaagg ggaaagtggt 153241 tatgtggcag gtatagcgaa taaagaattt aattaaagaa tacatttaaa gcaaattttc 153301 aacacaaaat attgaaggaa taatcagaaa attatttaat tattgtacat attatatatt 153361 caaatattta ttatgaaata tccctaacaa aaagacaata aaaggataat caataataaa 153421 aacaaatatg ggcaaaataa tatcatatag ggggtcaaga taagataaag gtaatatagt 153481 tatggatttc ttctccttag agattagttc aacaaggtag caatgtcgga tggcaattct 153541 tcaatttgag tggagtagaa cttttctagt tctctcatag cgccaacgtc ttcgttagta 153601 acaaagttga tggcaacacc ctttctaccg aaacgaccac ctctaccgat tctgtgaata 153661 tagttttctt tgttagctgg taagtcgtag ttaataacca aagaaacttg ttggacatcg 153721 atacctctag ccaacaaatc agtggagatc aaaattctgg aagaaccact tctgaattcc 153781 ttcatgatgg tgtctctttc ttgttgtggt aaatcagaat agatggcaga aacggtaaat 153841 ttgtcgtttc ttaacttagt ggtcaattct tcgacctttc ttctggtgtt acagaagatg 153901 acagcttgag taacggagat agagtcgtat aaatcggtca aacactcgta tttgtattct 153961 tcttcttcaa cattaacgta gaattgtttg ataccttcca aagtcaattc atccttctta 154021 accaaaattc taactgggtt tctcataaat ttggtggtaa cttccaagac gtcatttggc 154081 atggtggcgg acaatagaac aacttgagtg gttggtggaa gtaaggtgaa aatttggtag 154141 atttgttcct tgaaaccaga agacaacatt tcatcagctt catctaagat gaacatcttg 154201 atcttgtcag ttctgaatct acgtctttgg atgttgtcaa aaacacgacc tggagtacca 154261 acgacgattt gagcatctct caaaccttca gcgtcttcaa caaaggaagt accaccgata 154321 caagcgtgga ccttgatgtc catgtggaaa gccaaagcca tgacaacctt ttggatttgc 154381 aaagccaatt ctctagttgg agccaacatc aaagcttgag gagccttgac agaggtgtca 154441 attctttgca aagcagcaat ggagaaagta ccggtcttac cagtaccaga ttgagcttga 154501 gccaagacat cgtgaccttc aataataggc atgatggcac gttgttgaat ggcagatggt 154561 tcttcgaaac cgtaaccgaa aacacctctt aacaagtttt cgtccaattc catatcatcg 154621 aacttgtaga cgaccttgtc atagttggtt tgaatttggg attcttcaat atcagtaata 154681 ccttcagaca tattgcaatt actatttatt agtttcttgt acacaccagt cctttgttta 154741 gcgaaccttt ttttttccta ctatgtgtat tgggatctgc tgtttccttc tccttgagat 154801 gagatttctt ttatatatga tgctgaaaaa aaaataaaaa aatttcgaaa aaaagaaaaa 154861 ggtacgcaaa atcaacgctt tcacccggcc ttttgtattc gtctgatgtg acgactgtac 154921 agctaatgta tactatgtag tagtttagtt gaatgattga tagctaagag gtagagggat 154981 ggcatcaggt atcaggcttt gggaatgctc tttggacgcg gtctaaataa tccgtagact 155041 cccaatcaaa tttaaaagca gattgcggct tagatgtcgg tttctcaata tcatgtttct 155101 ctgcagtact cttctgcgaa gcatttcgat ctactgaggt tatatccagg tcaacgtgct 155161 tttgattttc tcttttacca tgattcaaca ggtcttgaag acaaggaggt tcgtggtaaa 155221 aatttgtctc tgtttcaata ttgcccaatt gcaagtgtgt gaagtagtta cttaagtggc 155281 attcactata aagttcacgc tgtgtacttc tccacagctg gtaatagtgg tcgtcatagt 155341 cagttgtatt acgggaccat ggcttaaacg ttccaatgaa gtgaataagt ctgatgtgtt 155401 gttggaaaaa attcatggct ggtgaagact ggtatccgta gttgggcatg gttacgttgt 155461 aggtgaaggg gaggcgtatc cattccatga gtggagacac cttatgcaaa acctctttgc 155521 tgtagttgca aataggatta aaaaattgat tgaagattcc ttgatcagca ccatcaatcg 155581 atacagtttt aatcaaaaaa tcttgtaaac ttgttgccat atctaaatca ggaattagta 155641 gtagtacacc ggtgttgaac atgtcaggcc atccgatgtc tggaaccgca gcaatctgga 155701 atcttgtttg ttcagggtat aatcgtagga tttcaaaaaa ttctttattt aatggtaaag 155761 tatcagcatc taaaaataaa acctgatcga actgcaccag ttcccacagt ctagccttga 155821 gtaaagtatg agatagctca ggccttttca acagttcaag atttgcctta ttcttctcta 155881 tgctcttctc ttgatccttt agcggttcaa taatgataat ctctttaaaa agacttctaa 155941 ttaaagctat ttcctgaggt ttaaactcat ctccaaacaa ttttttttca attagcaggc 156001 ataaggttat ctcatcttcc actacagcgt gtttcaagag tttttgtaat tggtacgcta 156061 aagtcaatgc gccaggtaaa tagtcccgtg aatacagcaa tgtacagatg gcaactttct 156121 tggccatagc tccgtaacaa accttacttc tgatagatat tcaaaaaaat gacacgatgt 156181 ataagtaaaa aaatgctttt ggaggtggat gcgctatcct tgatctactc ccctcatctt 156241 tatatgtcat agtaagtgta aacaaaaccc ttaacggcta ccgcgcggtg acgaatcaat 156301 gcgattttgt tttcgaacag tgctatttca aggataacga aaaatctacc tagattggca 156361 catcagtgcc ttattttccg tctttgcctc ttgatatatg ttcttttttt attgttcttt 156421 tgttattgta gttgttgcat gtacgtaagt tatatataga ttaaatattg ataatataat 156481 agaaaataaa tgatagggaa acgttgaata aacgacttcc cctcttcttt ttattcaata 156541 tttatctttt taacgggagt aagaccaaac gttcttcaac aaaccatcgt tttgagccaa 156601 acggttcaaa gagtcatcgg attcacctct ggatctaacg taaccggaca aagcgtaagt 156661 gatgtattca cctggaatgg cgcggccttc ttcatcaacc ttggcaacgt tgatttgaac 156721 agaagcgtgg tcatcggctt tgatgattct gttggtagca gaacactttc ttggaacata 156781 taattcaacc tagtaaaaaa agaaattatt caatgttagt acatttgcgc ttatattctt 156841 gtaaaattat tctgcacatg aatgaaagaa aagttctaag agtagttctg gaatatggaa 156901 acccactaat tcggaattat gatgtctttt cagcatatct ctcttgggat tccaattttg 156961 tcgttaaaac gccacatttc ttagagatgt gtacttagac cacacatgat aaagtatcag 157021 gtaacacttg tgccaattta aatgggttat ttgcattttc ttgaatttga tgtattacta 157081 accaatatga ttataaaccc atgttggtcc caccctattt gtaccactaa tcttgcacac 157141 ttaacttatt ataattttat ttttctgtcg atgctccctt gtctgtccac gcttactcag 157201 tcctcttctt tcttcctttg cgcgccatca tctgctataa tttacgtact aattgaccct 157261 tatcgttttc cattttggct tattgatatt cttttatttt tttatcagat ttttaactga 157321 aattcccctt taaagtcaaa ttcgttaaca atgtttataa aactttcaat cctataatcc 157381 tcaattacta gttcttacat tatacagagc cgagattcgc ttcaaacgga cccactagcc 157441 agctggtatg gttcccacca ccgatgaaga gaaccagaat aaaggcagtg gtctcactag 157501 cgaactcgct cgaagcgtgc ccaccagctc ccggcgagag acgcggcgaa acataaagca 157561 tttatttcat tccttaaaag ttatggagat gtatggatgt ataaagtgta cgggtgtaaa 157621 cacattgtcg tcaaaaggta atctccccag aagttttcac tcctatatag aaacacggat 157681 acaacctcga tagtgctttc tttgtcccat tttattatgc tacttgttgc attatttttg 157741 gtttttcaag cctacgtttt ggactctcag tccctgatgc ggataagtat tttacataat 157801 ttacgttact atggcaacag tacatatgta gaaaagtgaa agagaaaaaa aaagaagaga 157861 gaacttaagt agatgtatgt tcaaccagct attgttggaa ccaaatatgt gcaaaatatc 157921 gccagatatt catttcacga ataacaaggc aaaaatgttg caaaaaatgt ttcttagtac 157981 caaattgaac tactgccttt atcatgtgac tgaactacgc ttggctgttt tgtttttccc 158041 tcaccttgcg ctaaagttgt cgtcacatta taagggcagt aagaaaaagc agagtttaag 158101 aaagtttgtt tacatacaac catcacgtag aggaaattct tcaaacctac cagaccagcg 158161 gacacaagcc atttgtatag ataaaaaatg gtagatggac tgaatacctc gaacattagg 158221 aaaagagcca ggactctctc taaccccaat gactttcaag agcctaatta cttgctggat 158281 cccggtaatc atccctcaga tcattttcga actcgaatgt ccaaatttcg gtttaatatt 158341 agagagaagc tgttagtgtt taccaacaat caatcattca cattaagccg ctggcaaaag 158401 aagtaccgtt ctgcgtttaa tgatctctac tttacttata cttccttaat gggatcgcat 158461 accttctatg ttctgtgttt acctatgccc gtgtggtttg gatattttga aacaacaaaa 158521 gatatggttt atatcttggg atattctatc tacttgagtg gtttttttaa agattactgg 158581 tgcttgccca ggcctagagc acctccatta catcgaatta cgttaagtga atatacaacg 158641 aaggaatatg gtgctccaag ctcccataca gcaaatgcaa caggagtgag tctcttgttt 158701 ctctacaaca tctggaggat gcaagaatct tctgtcatgg tccaactatt gttgtcatgt 158761 gtggttttat tttattatat gactttggtt ttcggtagaa tatactgtgg gatgcatggc 158821 atattagatt tagtaagcgg tgggctcatt ggaatagtgt gtttcattgt taggatgtat 158881 ttcaagtaca ggtttccggg tttacgcatt gaggagcatt ggtggtttcc tttgtttagt 158941 gtgggatggg gtcttcttct tttgtttaaa catgttaagc ccgtagacga atgtccttgc 159001 ttccaagata gtgttgcgtt catgggcgtt gtgtcaggta ttgaatgctg tgattggttg 159061 ggcaaagtgt ttggagtcac cctggtgtac aatttggaac ctaactgtgg ctggcggtta 159121 accttagcca ggctgctggt gggcctaccg tgcgttgtta tctggaagta cgtgatcagc 159181 aaaccgatga tctacacgtt attgatcaaa gttttccatc tgaaggatga cagaaacgtt 159241 gcggcaagaa aaagactgga ggccacgcac aaagaaggtg caagcaagta cgaatgtcca 159301 ttatatattg gagagcccaa gattgacatt ctaggtagat ttattatcta tgctggcgtt 159361 ccattcaccg ttgtaatgtg cagccccgtc ctattttccc tcttaaatat agcataaaac 159421 aaaaggaaca aaaaaaaaaa aatagacaaa atgtagtgta aatgtatccg tttctaaatt 159481 aagtacttat aaaaaaatat gtaactgaaa aagtcatgtt gtataaaaat ttgaggcacc 159541 gtaccaggac cccaaaagaa gaataggtta aagtcatcat cattaataaa ccaggaaaga 159601 aaagagcata attaagatac gcctacaact ttggcgcgtg agccaagtgt cttctggtag 159661 ctagtgaggc actcaaggga ccatatgtct tggcattttc tctatattcc ttaaaagagt 159721 tgaacgagtt gcccggagat ctcttgaaaa tagtgctggc catggcgcta gcggctatcc 159781 ttgagacacc cgcggaggcg gctgaagaag agacggcggc ggctaatctg gtactttggg 159841 cgatcattta atacgtttat ttactgtctt atgaatgtaa tatttaaact tgtgcgtaat 159901 cattaaaaca aaggtgaaaa atcacattaa acatctccct acattacttt cggtttattc 159961 ttttatatgt gtgaaacttt ctctctgcac caggaagtgg tcatgcttga tgctcggctc 160021 ccaccggaaa aactaacttg cgggcgggaa attgatccct gaagtcatgc ccctcacctt 160081 cattcgtgga tcttatctcc agagcaacca aatgtggaaa tggcatgaca cccccccaca 160141 cacgttccgc ccactttttt tcaaatgtgt gacacaccca taccccataa tgttgcacgt 160201 gacaggtttg tatcacgtgc ttcttagggt tttgttttag gtctgagaca ttttagggtt 160261 ttttttcatc aagtctagat cgtttgtaac gaacgattgc tccttttttc tttttttttt 160321 gctttttttt tatactcacc gtttactgtc attatgtctc tcgagaaact gggcgtgtgt 160381 gctaaccaag actggatcac ctttacatag cacttattgc atttcttggt gtttcgtacc 160441 ctacaattga caaaagtaat tttgtcgttc atttcttcat cgattctttc ctctttcaac 160501 aacttcctta ttttatcttg ggatcgtaac ttcacttaat taatcacgat tcccatattc 160561 gttaacacct cttaaggttt gctgtaaata tatttatgtt ataaaaaaag aagatattat 160621 ggtagaaaac tcgtcgagta ataattcaac aaggccaatt ccagcaatac ctatggatct 160681 acccgattat gaggcgctcc ccacccacgc gccattgtac catcaactta tagcgggtgc 160741 atttgctggt ataatggaac attcagtgat gttcccgata gatgccctta agacgcgaat 160801 acaatcagcc aacgcgaaat cgctgtctgc caagaatatg ctttcgcaaa tatctcacat 160861 ctctacttcc gaaggaactc tagccctatg gaagggtgtt cagtctgtca tactaggtgc 160921 gggacctgcg catgcagtgt attttggtac gtatgagttc tgcaaaaaaa atcttatcga 160981 ttcgagtgat acgcaaacgc accatccttt taagacagct atcagtggtg cctgtgccac 161041 cacggcatct gacgcattaa tgaacccatt cgacacaata aaacagagaa tccaactcaa 161101 tacctcggca tcagtatggc aaaccacaaa gcagatttac caatctgaag gtttggcagc 161161 attttattat tcttacccaa ccaccctagt aatgaacatc ccatttgcag catttaattt 161221 cgtcatatat gaatcatcca caaaattttt aaacccatca aatgagtaca accccctcat 161281 acattgtctg tgtggcagta tcagcggatc gacatgtgcg gcgatcacaa cacctttaga 161341 ctgcataaag acagtactgc agataagggg cagtcaaaca gtttcgttgg aaattatgag 161401 aaaggcggat acttttagta aagcagccag tgccatatat caagtttatg gctggaaagg 161461 gttttggaga ggttggaaac caaggatagt ggcaaacatg ccggctactg ctatatcatg 161521 gacagcttat gaatgtgcaa aacatttcct aatgacgtat tagttggttc ttacatgtca 161581 tattattttc cattcatttt gcatctcaga agattatgtg tatattatca ttttcctgtt 161641 gtgactttat gtacatttat atatacaaat ttaatttgat aatcccaaag cttgagctct 161701 ttccctcaac gaaaagtttt cattttttct tcattacttt atatatctat gtttagtata 161761 cccaaagggt atttcggacg caggcaagct gccattattt atagcggaaa ctctaagagt 161821 ggtaaatcta tttctaaaaa aaaaaaagat tcattcaagc gccctccttg gttagttagt 161881 tagaaacatg tattcagagg gaattaaata aagatgagta taattagttc ttggttactt 161941 gtctctatta tttgcttaac tacttctatt gtaacaaaat tgcaagctgc tggagttact 162001 acccatctat tttatttaac aagaggtgct cccttaagtt taaaggaaaa ctattatcct 162061 tggttgaaag ctggttcttt ctttccggat gctttgtact catgtgcacc ttcaaataag 162121 gattggtctg attttgcaga attcactcat tggcccaatt tcttaatgat tgcagtatct 162181 tattggcagc aaaagtatgg tcagaacgat cgacttcggg gaactcacgg ctcactcgca 162241 ctaaagtcat ttttaatagg ggtattcact catcagatag ttgatgtttc ctggcattcg 162301 ttagttaccg attatagaat gcacggacta ctccgagttc tcagcgaaac agaatttgat 162361 ggagatattg aaactgctca tacgttttta gacgttatgg gtgaattcct caccttaaat 162421 aatgtaatcc gtgacagtaa taataacgaa aattgggatt ttttaactcg ctctgattgg 162481 aaattgccca gagaagagga tttaatggaa attataagga acgctggact ttcaaaggaa 162541 aagttgtcct acgcagaact ggaattttgc gttaaaagag gaatggcagc ggctattagt 162601 gaagggtacc tattccgctc tcaaagaaac caattgttaa ctaatattta ctcaacatcc 162661 cccagggcta atgatctaat actgaatcat tggctaggag ggcagtccaa tttggttgca 162721 atgctccaaa gatgcgtgcc tttcttcgag actttgtttc atgacgagaa tactaatgaa 162781 gctcaagcag aagaactgag attatgtgct aatttaccgc cagtatcaca aaaacggata 162841 aatgcacgac ctttggtctc ttcattaaaa gcacgtaagg gaaatagcca cattgtcgta 162901 tctcccatga aatcattttc cgattttggc acaagcctga ctatgggaaa atttcgagaa 162961 gacaacaagg attatctcgc tgtaagtgca ccacttgaag acacagttgg tgcaatctat 163021 atagttccat gggatattct aactgtagca agaaaagagg attttagcat tttacaaccc 163081 atcactgcca tgtacggttc aaaggtcggg acatacaagg caagtgatgt tgactaccta 163141 ctcgtttcac agcctggtac ctgtacaatc gacttttact tcaaaggagt aaaaatactg 163201 acaatcaagg atgagaccac cgaagaagca catcagttac aatttgctgt aacaggtaat 163261 ttttatgatg ataagattcc tgatttggtg gtgtcaagcc caagttatgg tgccaacgaa 163321 actggaattg caacatttat cccaggatct tccataataa gctatttgac caattcagac 163381 aaatatcaag tagttgatat ctcaactttt aagggcgtta ttaaccttga cgggtaccct 163441 atgaaaatac catttcagca tttcggggca acaattcaga tatctgacac gactgacaaa 163501 caaaagttaa tatatattac atgtcaaagt cttggtactg tttttgttta ttcgagtaat 163561 gatttacacg atttgtccat cccaatatat tatataacga aaaatggcgt cattccagca 163621 aaggacagtg accacgttga gtggcatata attccctcaa aagaacatgg tatgttcggt 163681 gcagccatat attcttggaa ttttgaaggt atgagttttg tagccgtatc tcaaccaatg 163741 tttgacactg tgtttatata tattgagaag tctgggcaaa tagagttttt cttaaaactg 163801 gttctaaaga ttaagacaaa atcagattca atcccggatg agtttggttc atctttgctg 163861 tttaatgacg aagaaaagaa attgtacgtt tcctccccag gcagtttcga tgcaagagga 163921 agtatatgga aaattagtat ggatgagcta ttaaaggcgg gaaacgatcc gaagcgcaaa 163981 acccttttga ttaataattt aaggcatctc atgctcataa atcctgacaa aagtagcaag 164041 ggtgtgtcaa attttggtaa tagcatgatt ttgggtcccc aaaatcacct tatagtaggc 164101 attccccaat atgggtatgg aaattttgat cacatgcagc taaccggtag aatcctggta 164161 ctttaatgat aagttattat gtacaagcat cggtttagtt caattacatt aatttaatac 164221 ttgaaaagca tatttggcaa tatgcgctat atatattctg atgtcatttg cttctattta 164281 catttcattc attttttttc tctgaatcct tttttgcaat ttttcttgcc tctccttctt 164341 tctcaattcc tttaacgccc tcttatcgtt gttttgtggt ttaacgtcct ttggtataag 164401 tttcattatc attttcgagt tcatgttacc tagcagaaca ggatcattag catattcgct 164461 aactatctct ttcaatgtct ccaagacagc agctcttttc tggaaaactg attctggtag 164521 cctgggtggt tcaccttttt gagagcggtc cagctcctca aaattttcaa gccaattgtt 164581 tgaatttatg ttattcttgt catcaagata taacgttact ttattccctt ttttcaatag 164641 cgaaactatt tcgtgagcct tctgcctttt taaatcatcg ctttcaatct gccatgatat 164701 tttaatatgc ttcaagttat cttctttttt atcagtcacc aaattcttgt aagacttatt 164761 cagtactccc aattccatca gttccttttc ctttttttta gccagaaagt ctgaatattt 164821 ttttaaggct acacgacttt cgactatctt aacaagtgga atttgatttt cattatcgat 164881 ttgctctaca ttaacaatac tgagtccaac tttatcgaga tcaatgccct tggcaaaata 164941 ccgaatattg gatgcttcaa ttcggtgggt agtgggatcc acaactttga tgtttccctt 165001 gtgatttttt ttgaatatct cactaacaac tgaattagct gcctctttag ctcgatctgt 165061 cccggtgctc caagtaatca ggattttttt cctgttagta gcattccttg gcacttgttt 165121 cgggcgctta atatactctt taggaaaagc agcatttctt gccacatttc catgactttg 165181 ctctttaaga tttgccagct cacgtttacg tttcattgcg ttgcgaaata tatctgtggt 165241 agatgatgca ttgtctctgc tgaagtattt tgtgcaatga aaatatctaa aactttttaa 165301 aaacagcatc ttctgtgaaa gaacatcact caaaggaact tttaacatat ccacggacct 165361 gatgttacct ccttactgtg tatgcatcag gtatgcattt tgtgatatat agctgttata 165421 gttttctgaa cttacttttt tagaccctta aagttcttac cgtcgcggga aaattcaggt 165481 aaaattcaag agctcaggat gaaaactaga caaaaggaac gagattacct tcaactccta 165541 tgccttaaac attttttgtt tcctcaagaa aatttgttta caaaatcatt ccatcttttg 165601 ttttaaataa aaactcgact ttgggaaatc atattattga gtgtaatata caaataaaaa 165661 tattggttaa aaaagtttaa taatagatta taaatttaaa atacggatag gtctcttatc 165721 attcacatat caacacccat gaccatggcc aacaaagcca ttctgacgaa caaaccatac 165781 ttcatttgtc tgaagtaagc agcacgatga tcgtagtcca cttcctcttt gatttcattt 165841 acacgaggca atggatgcat gatagccata ttttctttgg cgtgtgccaa gatcttgttg 165901 tccacgatat aagtatcctt cagacgtgca tattcttcag ggctattgaa tctttcttct 165961 tggacccttg tacaatacag aacatcggtc tttgagatga tatgaggggt taattcaatg 166021 ctctcaacac caagtaagcc agcttttctt agctcttctc ttaatccttc tggtaacctc 166081 aattccggag gagaaacaag attaattctg acttgatagt gcattaacaa acgacacaat 166141 gaatgtacgg ttctaccatg tttgagatca cccatgaaag taacagtaat accattaaca 166201 gtaccgattt cttcacgaat cgtaaacaaa tccaagaagg cctgcgtagg atgctcgcga 166261 gaaccattac caccattaat aattggaaca ggagaatatt tagcggcgat atgaacagac 166321 atttcttctg aatgacgcat gacaatggca tcactgtaac aagccaaagt tctgatagta 166381 tcttgaaggg tttcaccttt cttgacagaa gacaccaatg gattaacatt tacaattcta 166441 ccacccaaac gttccatagc agcaatgaat gaagaacaag tacgagtaga tggttcaaag 166501 aaaattgtag taataacgtg gcctttcatt aaatctaaga caccttctct tgcgacagct 166561 gcccttagtt cttgtgcaac agcaaacaac acatggaaat cagaacgttt gaattgtttg 166621 atagacaata tatgtcttcc gcggaatgga ttgttactac ggatcaaatt ctggatggcg 166681 cctggagcaa caagttctct tggtggcctt gaagacatca atttttgttc caaaggctgt 166741 tctggaattg catcctccgc ggcatctaaa ttatcagcga ttgcttcttc cgtgatcgag 166801 aaccttcttt tagcactagt agattggagc tctgcggaag cagttatgga agctggactt 166861 ggattaacaa tgcattttcc tttggcgcct ggtgaaacta attcaccgct caaaactaat 166921 gtttcgccat tatagacaac acgctcaata ccaccgttca tatctttgtt gaatggtgac 166981 catctcttat tacgtctgaa agaataatcc aaatcaattt cgacaactga gtcctgagta 167041 gggatgttga aaattttagc gggattgtca tgcagacgaa ggacgatatc atcaatggtt 167101 aatttacctt cttcaacagc agccaacaat agtggtaatg aatctttgat acccatacca 167161 acatcaacct tgttacctgt gacatttgcc aaggcgacag gaagagcacc gacagagaaa 167221 gcatcgatac tatcaaggtt gttccagaaa aactcttgat cttccttagt aggcaagaaa 167281 actgcctccg gatagtcatc ttgggcaata aacaaagaat aaatattgac atcacaagtc 167341 actctagggt cttttgcctt gaccgtcatg atcaaagcta aatcttcctt attcgaaaca 167401 ccagtaatgt gaatagatct gttttgaagg gaggttaaca ataaaaccga tgccaaatct 167461 gcagttttag cttctgcaat cacttgcttt tcagttggcc actgattcag aagttcagct 167521 actgctgtga tcttgttctt taattcacgt aggggcaaaa acaatgctgt cactttgcta 167581 gcagattgcg taacactatg agcattgtgt gctgtaccag caatagtgaa agaaaagtca 167641 gtgtaagatg aatcttggga aacagagttt gcggccttca aggatgcaac gtcagtaata 167701 acaggtccgc tgatggatct gggcatcaat tgacagtatg taaaaccgga ttccaaaaat 167761 agacgtgtgg tctccttcag ttcagctggg cctttgataa catgggatgc attcggaaca 167821 taagttgcga tattgattaa accaggtaag gtaatagttc tgtgggaagt ttgtgcatca 167881 cgttcagaaa catctaaagt gatatttctt gaaatggctt caatcaacaa ttttgcacat 167941 ttaacgttag taaccaacgg aaccgaataa tcgacagcca aacgacgtgt tttatacccc 168001 tttgaaacat aggatgcagg acgacggaac ctgttggcag aaggcaagtt gatgtaaagg 168061 tcaatttcat tattagccaa atgttgagta agtgagtatt ctgatttttg atcatcatca 168121 tccttgttta aaacctccag atattggacg gcaataccat gttcagataa aaagtcagca 168181 gtacctgatg ttgcaaataa tttatatccc atgttgtata gtttttgtac ggaagaaagc 168241 aattcttgtt tttccttgta agaaccaata gacaataaaa tattcttctt tggaagtttg 168301 aagccggttg ccaacaaaga ctttaagtat gcttcatact tcgagtggcc aaaagtagcg 168361 acttcaccag tagaggccat ttcaacacct aagactggat cagctcctgc taaacgtggg 168421 aaagagaatt gtggtacttt aacggcgaca taatcatctg gtaatttttc aacaggataa 168481 ggcgtcaaag gcaaacccat tatggccttt gttgccaatt caatcagatt gacgccaaca 168541 acctttgaaa tgaatgggaa agatctcgaa gcacgaacat tacattctat gaccttgatt 168601 tcattgtcct ttgcaatgaa ttggatgttg tatggacctg taattttcaa agccttacca 168661 attttagcag tggcgacaac aattctatcc acagtttcag gagccaaatc ttgaggtgga 168721 acgattaatg ttgcatcacc cgagtggaca cctgcatttt caacatgctc agagacaaca 168781 tgcataacca attcaccatt tcttgcaact gcatccattt caatctcctt tgcgttttca 168841 atatatttag tgataacaac aggataatca cgtgaaactt cgacggcttg gtttaagtag 168901 gattccaaat cgtttttaga ataaacagta ttcatggcgg caccggataa cacataagat 168961 ggacgtacca aaactggata acccaccttt tcggcaaaag attcagcttc gtccatggat 169021 gtcaattctt tccaagctgg ttggtcaaca ccaatttgat ccaacatacg agagaacttg 169081 taacggtttt cagcagaatc aatcatgtca ggggatgtac caagaatctt tacattttca 169141 cgatgtaaag tcatggcgat gttgttggaa gtttgaccac ccattgatac gacaacaccg 169201 cttgagtttt caatctcgta aatatccaaa actctttcaa ggttgatggt ttcaaagtat 169261 agtctatcag cctcatcata atctgtggaa acagtttctg gattatagtt gaccatgata 169321 gttttgatat tgttggcacg taatgttcta actgcagtaa cagcacacca atcaaattcg 169381 acagaagaac cgatacggta aacaccagaa cccaagacca taacaccgtg gtcatcaaag 169441 gataaatcgt gtgagtcagc attgtatgtc atgtataaat agttcgtgta agcggggaat 169501 tcagcggcaa ctgtatcaat ttgtttgaca aatggtgtaa ttccatattc ttttcttaat 169561 ctacggatgg caacttcgtt ggaatccaaa aatcttgcaa tctgtctgtc atcaaaacct 169621 aactgcttag cctgtcttaa aactaaggaa ggtaattcct ctttagtacc aaatgaacta 169681 attttctcag caaattggac caaatcgtgc agtttgttta aaaaccactt atcaattcta 169741 gtcatttccc agactttatc aacagaatat cccttcttag caaaagcatt tgcaatggcg 169801 aagacacgca tatccgtagg gttgttcaac tcgtaatcaa tgtcgatatc tagatctgtc 169861 tcattgaatc cgaggttagc atattctgtg gatctgatag ctttttgaat agcttcttcg 169921 aaggttctac cgatgctcat aacttcacca acagatttca ttgatgaaga taattcggta 169981 gaaactctgg tgaacttctt caaatcccat cttggcattt tgacaacaca gtagtctaga 170041 gaaggttcaa aacaagcaca tgtggatttt gtgacggaat tcttaacttc atttaatggg 170101 atattcaaac ctaacttagc cgcagtgtag gccaatgggt aaccagtagc cttagaagct 170161 aaagcagagg aacgtgacaa acgcgcatta acttcaatga tgcaataatc cttagaaacg 170221 ggatttaaag catattggat attacattca ccaacaacac ctaagtgtct aataacatta 170281 acagcagtag ttcttaacat attgtaatct tcatcagata aagtttgaga tggggctaca 170341 acgatggaat caccggtgtg aatacctagt ggatcaaaat tttccatatt acaaacagta 170401 atacagttgt caaaagcatc acgaacaact tcatattcga cttctttcca acctttcata 170461 gatttctcga ctaaaacttg aggtgaggat gaaaatgcaa cattacatag atcaaccaat 170521 tctttttcat tattagcgaa accggaacct aaacctccca atgcatatgc agcacgtaca 170581 ataactggga aaccgatctc cttgacagcg gccaatgcct cgtccactga attagcagct 170641 tgagatttcg cacatttttc attaatttcg tcaatggcat tactgaagag ttcacggtct 170701 tccgtggtaa taatagtatc gattggagta cccaatactt taactcctaa cgcctcaaat 170761 tcatctttca tggctatacc aacagataaa gcagtttgtc caccaaatgt cacataaatg 170821 gcgtccggcc tttcatgtaa aataactttt ctcacgaact ctgcagtaac aggaacaaaa 170881 taaaccttat cagccaaccc tttcgaagtt tggatggtag caatgtttgg attaattaaa 170941 attgtataga taccttcttc tttcaaagct ttgatggctt gagaaccaga gtagtcaaat 171001 tcaccagctt gaccgatgga caaaccacca gaaccgagaa ctagaacctt cttcgcttcg 171061 attctagggt gtgccttaac gttatcctct aataggccac ctgggaaagc gattggtttc 171121 aacacttgtg tatacttgaa ttctttaact gcttggataa aaacgtcaaa caagaattct 171181 gtatctcttg ggccaggtgt ggattctgga tggaattgga cggaaaaata aggtaattca 171241 gaatgataga taccttcgtt agagtcatca ttcgcgttaa caaacaatgg cttccatccg 171301 gaagttagag tgtcaacatc cacagcgaac ccatggtttt gagatgttat gtaacaacga 171361 ccacttatag ttgatgtaca aggtatgtta tgaccacggt taccaaattt tagttttagg 171421 gtggatgcac cggcagctct tgctatcaat tgatgaccga gacaaatacc gaatactggc 171481 gtctttttag cctccaggac atttgacaat ctttgagata gatcatctag aacagatgga 171541 tcacctggac catttgaaat aaacagacca tcataatctt ctttagtgaa atcgtagttc 171601 catggaacaa ctttcaattc tacacccctt ttgataaaac aacgaatttg attgtatttc 171661 atacccacgt caatggctag aatccttaaa actttaccat cgggtccggt ttgcaattcg 171721 atgtgcttat tgtctgctgg aggaacgtac aatttaggtt cattgatgga gaccttagaa 171781 actaggtttt gaacatttgg atccacccat tcaggaacat caaacgcact tctccaagag 171841 gaagatctgg agatggttct gtcagagccg cttttttcca aagacaacct acccaacatt 171901 gaacctgcat ctctcaaatg cttggtcaat gatcttgtat caacaccata aacagctggg 171961 atcccttcat tttgtaacca tttacctaag gaagatttag caagataatg agagtactcg 172021 tcggtatagt gagaaataac taaaccggca atatggattc tattactttc aaaatatctt 172081 ggcaattctt cgaccaattc atctctcaag tgcatatctg ggacaccata attgcctacc 172141 aatgggtaag tgatgactaa gatctggcct tcataagatg gatcggtcac agattcagga 172201 taaccaacca taccagtttg gaaaactaat tcaccagcga cggatttctc agcaccaaat 172261 gaataacctt gtaagaccgt gccgtcctta agttccaacg taaccagacg gtcacccgta 172321 gattccattg gaggggtgat tggagcagtg ggagcaatag tggccatatt atgattgtta 172381 tattctatta ggtaaggttt atgtgttgta tgctgcaatt agttatggat ttctatcgtc 172441 gttaatatta atgttagtaa ttgttgatcg ttcaagccag atgccgatat aaaatcagaa 172501 ctaattgaag agattgattt gctttcgtgc catgaagatc tctatcaatt gcgattcttt 172561 tctttttttt ttctttcttt tttttctttc ctattccagg taatgaaaaa cgacatcatc 172621 gcagagtcaa acggcttcta ttttccacgc ccagatacta aaatacgcgc ccactgatat 172681 tgcgactggc atcgcatggt ctgaatagat ggcaacatta aggcttctca aaagtaatca 172741 taaaaaacat actcaaattt gaatgctaac ggattataat gtttcctttt tctttcaatt 172801 caaagttgaa cgtggtgagt ctttaacaaa agagtagaag tatttataag tttttttggc 172861 tagatatagc ggtattcctc aattctttct caagtgcttc cgtagagaaa atgttcagga 172921 aaccttttgt ttgtggttgt tgtcgacagg ttttttattt tctacaatca agaataagat 172981 aaaaatacaa gaccattagg aaagacgata atttgaaaga aaattggtgt agttaaaaca 173041 tactagatat gatattatac taattgagca aaatagagaa ggaaagagag gattctctct 173101 ctgagtaaaa tcgatgagtg gggattttgt caaagtattt atactttttg tccataccat 173161 ttgtcctact tttttaccgt tttttttttt ttcaaggcca gggaaaaaag agtcattgcg 173221 tttgtgtgac atttctttta atattcatcg gagaacaccg gcgggccaca gagaaaaaaa 173281 aaaagtccat attccatgta cactgcaaat aaccaagatt tttcattttt cacgaaaaga 173341 gggacaatgt actaatggcg ttgacgatga cgaaagcacc attttggaca ttgtatgtcg 173401 tacattatcg tagagagatt cggttgtctt taagggaccg aaaaaaagaa agaaatctta 173461 ggacatcaga aatgtacgta ggcaaatgta tatcacaatg ttactaatca aggttaaaaa 173521 aaaaaaatcc ttttaatgct taattacctt cttaaatatt gagtacgaaa acctatttct 173581 aaagaatgag tatatatgtt agagcgttgt gctgctcctt ttaggatttc gggaatgtgt 173641 ggtcttacgc ttaagagctc cccaacgatg tttcacatca gtgaaacttc tcttgaaatg 173701 ttccgtcatt gggtcttctg tattggttct agcctgtctc ttcaatttca tgccctcaag 173761 gtggtcaata tgttcaagtc tatcactagg caagataatt gcacgatcca gtgagtatgg 173821 tagacctcta ttcttgcctc tgatcagcat agctatgatc accaacttag ataatgtagt 173881 aaactgtctt gaaaacgatt ggttggtgtc cggataacct agcgatagcc caactgtacc 173941 gtaagcgcta acaatttcaa aaagaattgc aaatatatta aagtttggtt cttgtacgtc 174001 ctttatcttg tccccttcac aaatgcaaat gataaataac cctaaaaata gaaaccacaa 174061 gtcaaatgaa agctgtttcc ttaaatgggc accgataaag gattttgtag atatttcatt 174121 tggattttca gttttctttt tctttttctt tttcctgttg ttattgttgt tgttgttcga 174181 actacttctt tgactacttt gaccttcgtg actctcgttt tcctcgtcgt catcttcatc 174241 gttaccatcg tcttcagtat ccgtatcttc tggttctccc cccatatctc catatagtcc 174301 taaagattgc tcctcgtaaa catttgtccg tcgaatagag atggccaatg gtaatacgga 174361 gacatacatc attagcatat aggagacttg gatagaagga tgcagttgac ttaaatcgac 174421 aacgctgaat ccagcagttc ttgtgctaac agattgaaac aggccgacaa ggactctata 174481 gcctttcgat aatgatttca caactgttga gccaaaatct agaataataa ataaaatcca 174541 atcagttata ttcaatcctg caagcgttaa aagtagccac catgtagctg ccttaggaaa 174601 tagcaaggtg aaacaacgac gtggatggtc taagagaaaa cctaaacttt ctctcatctg 174661 tgataaatca ggagaaattt taaacattat ccaaatgatg catctaagaa ggatgggaaa 174721 ccctgtattt ccgataatga taaaccaaat cataacgatc aatgggtata cagctttgtt 174781 aaacgacatc attgaatttg gagttaatgt caaacctaaa tcattaaatg cactcattgc 174841 tgtccaaaat ccccaccatg taggtgaaac accatcatct ctaacaactt cactataatg 174901 ctttttcaaa ataatccaag gtactaacat aacaaaagca acaatatgcc atccaacgta 174961 gtagacaacc aatatggtgc ataaaagttt gattgctctg tactcgacac cacctaattc 175021 atctttctgg gctcttgtta atccaaggaa gtttgagtta cgtccaatag ttggttgcca 175081 tgatagatac gttttaccac tgcctttaga taaatcatga cgaggatcta ggtcataatc 175141 ggtatcgaaa tgtaaaccat aatagccttc ttcatcgtcg ttgtaagtag gatagttgtt 175201 aagaccattg tggtcgcttc ctccattcgt ggaatagata ttctcattag agtcggaaga 175261 ggcttcttcg cttccatttt tatgagagcc atcatgatgt aaaatagact ctgcgtaatg 175321 aagaatactg tttccagtat tactattatc aggataattg cgatcgctgt cagatgcata 175381 gggaccatgt tcaaatatct tgttattcca tcccctcttc ctaaagttcg gtttttttct 175441 atgatgggct ttccaatttt gatagaccat tttttgaaaa tcaggcgtcc ttgcgagctc 175501 atttagatcc ttagcctctg ccatatcgat ggtcctggaa cgttccatag gaactgctct 175561 tgaacgatta tcatcaaatg atttggtttt atacatgcgg tgcaggttct gctgcagttg 175621 gtgtttttct tgctgttgtt ggtgcgattt gagttctgaa tcagaatgtg gttcagactg 175681 ctgtactcgt tcatcttcat cgccgctttc gttgtcagca aagtattctt cgttgttatc 175741 gccgtcgttg tcatcgtcat catcatcatc atccatatca gtaataggtt ttctatctga 175801 aacattgtta ctgctgtttt tctcaattga accagtagaa agccttctct taatttgttg 175861 ccgtattcgc cgcgctttag gaaaatgttt catgaggtac ttcttcgatg ctttttttcg 175921 ataaagaacg gaagattttg ggttcaaatc atcgaaggtt gaaactcttt ttgaaatttt 175981 tctaggaggt ttagttatat cgaattgaat tgatggccca tgctttttgt ctgtttctgc 176041 gttatcagta atggctatcg ggcccgaatt tgatctatga gtatttgttc ttaatgaagg 176101 tactttgtta ccaaaatttg tgtgtaacga gctttcgtcc gaaacgctcg ccgtactgtt 176161 tgcttcactt gacacggaat tttgatcagt gttactttca tttcccttat ctcgaatctt 176221 gattttgtta ccatttatgc cggtggcctt ctttagctta ttgacattac ttttatatct 176281 tgtgccatcc gcaggggacc cgatgactaa agggggacct tcatcttcag cagttgcttc 176341 atgcttacct tgtagcatca taatggatcg atacatatcg gctgggctaa tatctcttga 176401 accccttctt tttgcaaatt tctctgaggg aactcttgcg ggtctttgtt tgctgtgtgg 176461 ctcatcaaac cgaagactgc ttggcttggg cttctgattt aaactttcgt ctgcaactgt 176521 gttagacgaa ctacctaccg tcgagtagga gttgttctcc tgatattctc cattgtcatc 176581 cgtttcgtct tccttaacga aatcatctaa actgccactg ctaccattgt gattcgtatt 176641 attattgctg ctgtccctac taatgtcatg agaattctgg tcgctgtgaa ctgagtcctg 176701 ctcatctcta ttaaccattt ctccgctgaa caatttttct tggaaatcat ctgttttagc 176761 ttgtttccta ggataagacg ttctttgggt acctgttcta ttcttggtca tggttcttgc 176821 tgttagttcc ctttctaaga ttgttttcgt tcttctcatc ttaaaatttc gtctagaaga 176881 gtctctaata ccatcgaagt agcgctcaaa ccagtaaagc cgtacaaatg ccaagcaact 176941 atgaactgca attggtgttg atatgcagca tacgatatac agaacaattt gttggtataa 177001 gcttagattg ttgatatcca cagtatttaa gccaccttgt gtaactgcgc ccgctgctaa 177061 aaacaatgta tcaatgtatc tggtattctt aatgggatat agcaggattg aagttattaa 177121 tgtcagggat atcgtgtaga agtagtgaac cgcgataaaa ctggggaaga tatatttttt 177181 aactggagca aaatagtgac cacatagagc aataaaatca cgaaatttat ggccgaaaga 177241 ttttttatat cgtatttcaa gagatgccaa tgtgggcact ctactcatcg ttcttctaaa 177301 atgcattgtt agttatcaaa aaaaggtaat aactttaagt aaaatggata ggaatgactt 177361 ccttgagagc caatagaata ccctccttct ttttaaggca atacaagtgt ggaatcagtg 177421 atgctaatgg taaggtaaaa acaatgggcg aaaggaaagc aacagtaaca aaaagtttct 177481 aataatgtaa gagctcttta tcttgatagg taattattta ctgttttccg tgaaagtagc 177541 aaaatttaga agttagggta agatacaggt atagttcctg gtccagactc cacatctact 177601 ctcaataacg tggatttgaa ctttcaaaac accttttatt ttctcgatga ttttggactt 177661 ttttttcttt cctagccttg agccgtaaag agcggaaaaa ccatcagaca attccagagc 177721 attttttctt tcttgcgttg tcagccccga acgtaaataa tttcgaggag tcgatggccg 177781 tagcaataat cgaataacac aatatattga cgtccacatc gcttcacttg ccggtgcttg 177841 aaataacatc ccctcaatac tctgtcataa ttcgtgccct tttttaggtt cgacaaaagg 177901 aagtcagacg atatatatat atgaatatat atatatatat atgtctataa cgagtataat 177961 gcaagtttat tacaataaac atatgtatat gtaaggtttt tttgtattcg ccgcatcatt 178021 tccacagtag cttttcgtct gctttttttt tgttgttata ttcacgtgcc tgtttgcttt 178081 tatttggata ttaacgctat aaaccaccca tatgtaatgc cggtacattt ttagataaac 178141 cattctcacc acgttcccgt aagattttgt tgcgcctttc taatcgttca gtgatatact 178201 cactcatgtg gacatcctgg tttctgtatt ttactaacca aggatgctct gttaaagctg 178261 cgtatgtagg tcttctttcc ggaatctttt gtagacataa agaaacaaaa tcttgtgcgt 178321 cagaactgaa tttatctgaa ggtaatctcg gtggcggccc atcaacaata gcgctcaatt 178381 gagagaaaat gttgtcgtat gtttctggtg gatacggata tctacctagt gccatttcca 178441 gaatgcttaa acctaaagac cagatgtctg actgtacggt ataggtggct ctatctggat 178501 tcaacgattt gattcgttca ggtgccatgt atgactgaca accaatatta gtcttcgcta 178561 aagatgccac caaattacca gaaacaccga aatcgcacag ctttacggtg ccttggttgg 178621 ctgaacataa aatatttgtt ggtttgacat ctctgtgtat gatattatgc tgctctttga 178681 gttcttttag tccatgaatg acagcattgg caataaacgc tagctgaggt tcatcaatgc 178741 cgccgatttc agatgattcg tcgtatattt tatccaagga accaccatcc atgtattcca 178801 tacacatgta gacggcgccc tcaataaaga atgcaccata aaaatccaca atatagggag 178861 aattgcattt atgcaaaact tctagttcca ttaaaatttg tctaaattta gcctcatcta 178921 gctccaaacg gacttccttc gtcgccataa taacatttgt gggcttatgc agtacctttg 178981 agacgttacc atagttacca tgacccagtt catccaaaaa ttctagttcg tccaatgtaa 179041 ttctcgaact agaaccattg ctgaaatcta ttcctttaga ggatagcgat agtttgcctg 179101 caaaattcaa agagccggat ttgatatcca cgtatttcga gaaatttgcg aaaagaccac 179161 caccaccact actaccagaa tttgaagagt tgttgctgtt tccagttctg ggtgtagtgc 179221 ctacagtgtc atgtgggcct tcggtacttg atgaggtgga tgtgctttgc acaccattta 179281 tcaaagaacc cggattcgat cttttccctt caacaacttt gctgtttgat aaggtttcta 179341 tatgtttttt gtttgaaggg cttggggcaa actgctgcgg ctgttgagct gttttagtgg 179401 gcatttttaa tgacattcct cctggtggta atttgagccc tcgacgggca cttaaacttt 179461 gttttggtgt gttgattata gcaggggcct tatgcggggc aacatttggt cttgtagggt 179521 gctgggtaga aagcggcctt cttggtgccc ttctgttagg attcagcaat tgcgccttat 179581 gtgttgctga tgcagtatta gaaactgacg gcgtaatgtc agtagcaggt aggccagtat 179641 ttacaccaat tgttgtggcg gtaattttgg ttgtatcgat gttaatattt acgtcggtaa 179701 tgttttgtgt ttcttgattg tccagaacgt tcttaagagt gctcttggag gacgcttgca 179761 cgacttggct actcattctt tgtgaaacct tagaacttcc tgctacggga agaggcggca 179821 atggcttatt aacaatctgc tgaatatgtt taggtgattg tgaactgcct ttgtcttgct 179881 cgctttgatt actgcccacg ctggcagacc ttttcaatgc acgttgttct tgaaaagctt 179941 ttacacgagc atgaaggtca gcgttgatgt tattgtagtg cgaggacgtc gaagatgttc 180001 tcttgacagc agagccatta tctgagcctg tttgctcgtt taattggata gatgacttac 180061 cagttttctc atggagactg aggttagcaa acttgtcttc catctttgag aaattaacgt 180121 ctcgatctgc ttaatataat aatgtatcta tagaaatgta cggaaaaacg ggtactttat 180181 cagttttagt tgtatgacgt tgatgtctgg agaaggacaa ggaaaaagta gttctgtgaa 180241 acgtgtaccc acaatagcag ctacccttgt cttctttttt agtaattctt ttcttccggc 180301 aagcaggtaa gcagttatct ctgtgtccag atccctttga agtaaagttt attcaatttt 180361 ctatagaacg tgtatggctc acgaaatcgc tcactagtag acaacacacg ttagaaagat 180421 cctttcaggt gcaacgggac gcagagggaa aaaactggaa aaattgccac taatgaaaag 180481 gcaaatagag gatgaaaaag aaaaggtaaa tgcagatgaa aggacgaaga cagatgcgat 180541 aagaacagcg tttgagatcg gatgcaaagg atatagtttt gctctggcac tgtgttagtg 180601 tgcttgtggg tgctttttct tctatttgca agaaaatgtg acctttgcgg ataacctata 180661 taagacgggg tttccttgct ttgaaaagtt taaaacagat attcttgcag atacaggagt 180721 acatacttgt gcgatcatca ccaagataac aagagattaa tcaaatatag aaacagatat 180781 ataaaataga tacagagtgc tacgcaataa gatttttttt tcctgttgca atactatact 180841 acgtcttgac atgaactctc aacagtgata tttctgggga gttgtatcga tgtgtagtaa 180901 ctggtagtag tctagtaatg agttgttctc atgttagtga atattctgta tgcttccgtg 180961 cctgctgcta tgctcaaggg gaacagaaaa gcaacacgct caaaatagta atctacatga 181021 gaaacaagac ttagtcattg ccttttgcca gaattggctt cggccgtagc tgttgaagtt 181081 aatcccgcag taaaagacaa acggctccgt attcagcagt tctatatatc acctcattaa 181141 gacacagacg atcttgacag ttgcagcaga aacacgccac catatgttct tgtagctaca 181201 ccacgattga gtgtctgcac tcttattcaa gtgtttcaac taaaaataag tctaagctga 181261 aagattatta ctttcatttg atttttttat ttttgaagcc ccatttcctt aaatcgttct 181321 cgtggacgag attaaaaata gaaatgatgt agaggagatg cactaaacat tgcctccctg 181381 caccgcacaa ttactgtagc cattgtgctt atttatatct acctatatat ctaagcagct 181441 atatcatggg cttgacatac gcgacttctg cttgcttttg tgctctcgtt caaagagcaa 181501 ttacttcatt ccatctcaag aaggactgtt gcaggtcatt atttcatttc ttactgcacg 181561 tatttcgatt gagctgctaa tgaaatcaca acacaactac ccaaatagcc taagaattgg 181621 aaaaaggccc ttcttgataa ttggatctgt tgagttggcg tatgcaaagc tgtaaatatt 181681 gaacggatct ggttgaaaaa gaaaatcatg ctttctttat tgtcgcgtaa actgtacact 181741 gctgcaatta tctagctggc tgctagtagc aatgtgctct tcgttacgct accgtagctt 181801 ttctccgtga gtgactgatt ttgctgctgt acatttaact ccttttctat ttaaattgtg 181861 cgctgccatt ttccgcatcg gaaaacctaa gacaaatttt gatgagtata cttggtacgt 181921 gcccacgcag ccaatagtgt ctcgttcacg gcatcagata cagcagtact taaaagggca 181981 ctgaggatca ggtttcctaa tctggaaaat tttgcagcac aaagcttagt tatttatctc 182041 cgattatgga tttctgcagt acctaggttt caacgtaaaa ctgtaacaga acctttcgtc 182101 atgcaagcat aattgagttg agtgccttgt ttccaatttc agtttccaat tttacttcaa 182161 aaatcacttc tgaaataaga tttaagactt gtcaaccctg ttccaaaagt ggacgcatca 182221 ttaaatgtac cttttttctg tacaaacttt atagtttcta gggttggtga tgtgaccgtc 182281 tctggcagag tcgcaattta ataataaata ttagaattgt gctctgtaaa tgtattagat 182341 tcgttgttaa caatcttagt gactgaattc tcattacctt cactgttgtt caaatcgatt 182401 tgttggccag tcacatcttc acctcgatga tttatcttct gttgttgttc cttttggacc 182461 atttctagag cggccatgac gttatcttcg aggctcaaca tagcatcgtt cattatagta 182521 tggtcatttc tatctaaatc gggaactgaa tggttcatat ctcgttcatc acggttgacg 182581 gggttcgcgt gatcctgcga ttcgttattc gttaaatggg gtacaattcc gttggaggca 182641 acatccaagt attttcgtct ttttcttgag ttttcttcct ccacgaatct attgaaggaa 182701 ttcattgact gttcgtcgtc caatagtggc gtgctctgta ttgaggaaag aaactcggat 182761 cttttattcg cttcgttggc ttcagctgtt gttgcgggac tattcgtggc gttctggaat 182821 gtgggttgta cgatattagt gtctggcgga gtgggttcac cctccacatc attcagcgta 182881 ctggaaataa tattttgagg gaaatttatt gcctgtccca ataacgcatt atcatgcttc 182941 ttgctttttc ttggattgtt gatagtttct atatgctgcg tcggtagcat atgcgcctgc 183001 ttaactgctc tcttttgttc aattattacc cctgtcccgt ctttgtacct catcttgcat 183061 ttttggcacc gagagattac ctccgaaaca gtactcttga ttcctctcca atggtatttt 183121 tcaccaattt tggaggtcac cttgttgatg cctaaatgtt ccattaaatg tatctctaat 183181 gcaatctgga tttgttgatc cgtgtcataa atgatttctt ttccttttgt catcaacttg 183241 ccattcaata ccgaatgagt tttggaaagt actcttaatc tagccttttc gtttctatca 183301 caatgtaaag gatacttgcc tgtttccaga aaatgcttta atcgttcata tttcccaatt 183361 tcgatactct tttgaggatc tcgtaacaaa tctatacttt tcgtaatatg tgtgaactct 183421 ttaccataca tgaaagaatc tactgggaca tcaaagccct tgagaatccc ggcttcaggc 183481 agctttccaa tccgcctaaa gttcaatcct tccaaaattc ttctgattcc tacgttcgtt 183541 ccgtaaatta acgggaaaaa ggaggacgta aatcctaatt tctttgacca ttctatgaat 183601 gtttccatta gtgttttccc aatacctttt ccacgaatac cagcattgac cagaaatgtt 183661 cctgtgacca catgcgctga ccgtccaggg tatgctggtt tgaggtcaaa tatgcctaga 183721 cattgcttct cccactgcat acttagattt aaattgcgac gttcttttcg tttcttatat 183781 tgggtggtgt gcttcgtggt ttctatttct gttccaaaat tatcatttgt gtccgcttca 183841 gtatccatac tataatccag ttctggtatt tcgcctaaca ccataataca aacgtgacca 183901 tcattatgaa accagacatt tttgaattct tctagtgata aagtctcgta ataaggaaaa 183961 ctatctccct tttccacttc catgttaaat tcatctagaa ggaaatttaa gagccctagc 184021 ggcaataaat caggatacgc aggtatagga tacatcgtag ctattgtttc tccatctttc 184081 aataaaatgg tatacggttg taaaggagtc aaaagttgat ctgggaccgc tgcctcattt 184141 ctcacttctg aactgctatt ttggtgtgcc atctgcagat gttcgtcatc cggtactgaa 184201 cttgtgtgct gatttagcat tgaagctaat tattacgatt tttgttgata atcactttgg 184261 cggaagtcta gagttgttct tgatcggtac actttttact catcccccga gcagtgaact 184321 aacgccaatg taatgaattt tgctctttta tatttttcat ttttttatta ttttagctca 184381 cgatccgcat ctcgaatttt cagagcttac tagattctag gccattagaa gtaaatgaat 184441 agaggtgaaa taaaattcat acccatcatg aagtctcctt cataaaatat aacaccgcaa 184501 atgactagta aattaaaacg ggttgctgtc gcacaattat gttcatccgc tgacctgacc 184561 aaaaacttaa aagtggtaaa agaattgata tctgaagcca ttcaaaaaaa ggcggatgtc 184621 gtttttctcc ctgaggcaag tgactatctt tctcaaaacc ctcttcattc caggtatttg 184681 gcacagaaaa gccccaaatt tattcggcaa ttacagtcaa gcattaccga ccttgtcaga 184741 gataattcac ggaatataga tgtttccatt ggggtacact tgccgccctc agaacaagat 184801 ttacttgaag gcaatgatcg agtcagaaac gttctattat atatcgatca tgaagggaaa 184861 atattgcaag aataccaaaa actgcatttg tttgacgtag acgtgccaaa tggaccgata 184921 ttgaaagaat caaaatctgt ccagcctggc aaagccattc ctgacattat agagtctcca 184981 ttgggaaaat tgggcagtgc catttgttat gatattcgct ttcccgaatt ttctttgaaa 185041 ttacgatcaa tgggggctga aatcttatgt tttcccagtg cgttcactat taaaacaggg 185101 gaagcacatt gggagttact aggcagagca agagcggttg acactcaatg ctatgtgctc 185161 atgccagggc aggttggaat gcacgatctc agtgatccag agtgggagaa acaatcacat 185221 atgagcgctc tcgaaaaaag ctccaggaga gaatcttggg gacactcaat ggtcattgat 185281 ccttggggta aaataatagc gcatgccgat ccctctactg ttggaccaca actaattctc 185341 gctgatttgg atcgtgagct tttgcaagaa ataaggaaca aaatgccctt atggaaccag 185401 agaagagacg atttatttca ttgaggcaaa taaaatatga aaaaagcctt tattcgtaca 185461 gatttgcttt acatattaaa aatttcaaaa acatataatt taagtatata agtagttaat 185521 catttaatta tttttccgtg gatcgaagaa tttcgttaac tttttcatca tctcttgatc 185581 tattcacaac tttaaatgca aaagtcaaat atgaggtatg ggatttgatc tcagcttcca 185641 tctttgtgac ctccttccat ttataattac tatcaccttc cttgattcga gaacctttgc 185701 caaaaggatt aaatttggcc ttttctgtta atggtacgcc atcctcgttt ctttttccaa 185761 ctttttcatc gttagaatct attgtattgt taaacatccg cttgcgtctt tctacaccct 185821 ggagtttgtg cctcttaata tctctcaacc tttccagggc atcattgagt gatctgacca 185881 tttgtcttcg actttcgtac tgtctacctt gaatttccac catttcaaca tccgtccagc 185941 catatttctc taatacatcc aatgttttgt ctacttgctc aatgcatggg gagaagcaac 186001 acaatccgac cttttcgtct acggaaataa cagaatccag atgaggtata gcatcccagg 186061 gagccggcag atctaaaaac actacatttg cattcaatga agcggcggtt tcattattgc 186121 caaattcgta agatgtagtg tctcccttct ttataagaaa tccaccttgg caaacatccc 186181 gatgtgtaat cgtaacgtta tcatcaataa gtccatgctc tttgaattcc tctaatgctt 186241 gttcgtatct tatgtgatga aattcaaaac taaaaagatg acctacagat cttgcaaaag 186301 cgtgcgaaaa tgatcctgag cctgtacctg cctcgatcac tctgctgtga gggctacaat 186361 tcaacctttg catgatgtag gaagagtcgg gcgtatatac aatttgagtt ctgtgtggta 186421 acgacaaagt ccacaattca ggagttggtt gcagaacatg gacgaatgca aacttatttg 186481 agccctttgt tcttatagca atttgagaac cataaggttt acctatgata tccttatgag 186541 gaaatgaacc ataacgagta ttgaatacct cttcggaatg catccttacc ggtttgatgt 186601 tatctctaga aacccatatt agagttaaat cgccttcctt gatgaggtct ttgtaaccgg 186661 aaaaacaatt tgttgacatt tctaaatctg cgtaatctta gctacctgat agtcccaccc 186721 cgatcttatt cacatatatt ttctatatac tttaaacagt tttaaaagtg atgagcatgg 186781 aaaaaaattc gttgctaacg gcatggcata aacaaaaagc gaaaaaattt tatagataat 186841 aataaagaaa aagtatcaat agcatgagtg ttaatgttat aacgaagtgt aagaggaaaa 186901 agaatgctgc gcaaatacgt tacttcataa aaaaactcaa gtactgtata tattttacat 186961 ttaaatatat taatttatat acaaatacgg cctcctctct tgcatttttt ttattgttcc 187021 atctccaaag gcagttgatt aagtgtacgg ataggtaaaa ctgaatgtgg aaatttttga 187081 gagtttactc caggatatat gttggtagta ttgtgttttt ctttcttagt acatgtcaga 187141 tttatggaaa tcgtaaacga taccatggcg ggccattttt ttacctttgt gggtttcctc 187201 tttaaacctt ttctcatcat ttttttgctt ggtcagccaa gcctccttaa atggtatgcg 187261 ttccatggcc tcaaggggtt gatcttcttt atcgatgtct acttcgccta acatgacaac 187321 attttcacca cgaatcatga atatgccgcg gtcttcttca gcgtatttgt tttcttcgct 187381 aaaatatatt ctctccacgc aatcttgaag tatcaaattt gcatattggt caaaggttct 187441 tagtacaccg aatagcattc ttccatcacg caaaagaacg aagattttac ggtctactga 187501 gcttacaata gcagcggtgg tagtgaagtt atactggtcg agatataaat cggcctcacc 187561 ttctgaaatc ttctttggga aattctgctg ttgtcgcttc gcatcctgat tggactgatt 187621 tctgtccttg ctatttgcag acatttttgg tgaattaatt cgattcgagg gctgctttct 187681 tttataggtt ttgaaagcgg agcaaatgtt ggtataactc tactgcagcg ttggcaatcc 187741 tgttgaaaag gaaaagaaaa tataactaaa ctgtgttact tgtatcttca ctaatattta 187801 atcagccctt ggtcatacag gcttccccta gattgaaata caggtgctga acaccgttgt 187861 atattcacga cttcctctat ttttttcata ttttccatta ttcaacgaac gcgggtaaca 187921 agtcggccga atttgaaccc actcctctgc gcttgtaact ttatacatca tcgttacgct 187981 ataaatgtta tgtattaagt gtatcaaaga cccatacggt caatgacata attctgtgcc 188041 atgaccccaa atgacaagct taatccatct tcgatccatt cctttaccca ttcactagga 188101 tcaatgatct catcgtcttc gtcttcgtct tcactttctt tttgtttctt ttgatcgtat 188161 gacttattcc tctcctcact tgctgttgat cctgttttct ccacggatcc ttctagccaa 188221 ttgacccatt tgacagggaa tccttgtgat cttgttatgg tggtaatatc gttagttatg 188281 tctttcaata caagggtgaa attgaaattg cctggcgtat tggagtcggt cacttgaaag 188341 tcaccgtcgg catctttttg tttttgcgga atggcaattg gtaagatgga tatgaataaa 188401 tcactgattt tattgctgtt actgctaata gaactcctat cgtcatctgg agtggcatca 188461 gcctctttct gttgtttctg gtattcctca tgtgcagtat tgaagagttt gactgcattt 188521 tccaggtttg caaatgccag tttctcaccg tctgttacct tgccgtcgaa tagattaaac 188581 tgtaattttt ttttagagtt gcctaactca ccgtctgcaa ctgaaggctt tttttccaca 188641 ggtgtaattc cattattgtt aggatggccc cattcatcta caaatattct gattcctccc 188701 tcaacttgtg agcttagaac ttgatcaaac ttgctttcaa tattgtattg taatgaggga 188761 tagttaacca aatcatggac tagatgaatt cgcagcacct cttcagtctc accaacaacg 188821 attttctgta agtttctggc tatttcagta atcgtgctcg tgtttatctt tgaagtcaaa 188881 tcaagctgtt cttgggcaag tcggtttttg atctgggatg cttgttctgc agttttattc 188941 caaatactcg atacctttgc ggatccagag gaggaccacc agtttgaaat agaagcaatt 189001 gggtcatgca atggggtctc ctcctcctcc tcttcttctt cttcttcttc ctcctcttct 189061 tcttctttct cctgctgctg tggttccttt tcctttccgt gagcgtcctg ctcggaattt 189121 ttgttttctt ttgattcttc tactttttcg tcttgtgctt tattattaac tgattcactg 189181 ggagccttct tttcaacccc tttcttgtca gttaagctta agttactctt ctccaactct 189241 tctaagaatt caaagatatc atcgtcacct ttctttccat cattcccggt cttgcccgcc 189301 acagaattag aacctccctt aacgccttct tggctaccct ttacgtcagt attaaccatt 189361 ttcccgccat tctttgcttc tggcaaagaa tctaaaaatt caaatacgtc ttcagcctca 189421 gagttcttat tttcagacat tttgccctgg tagtatgtat gtttttaatc gattgagtct 189481 agttaacctg tcccttgttc tattcttcac cgtctcgtcc aacttccatc aaagaaccag 189541 aaaccagaaa atcgccggtt tcttccacgc gtcaatccgt ttggaatgat ctcatcgcaa 189601 aatttttttt cgctaaaatt ttcatagaga gtatcaatat taatatatgg ttataactta 189661 tggcggcatt agtcgatgag gtgcttgccg aagagactag cacagccaac ccataatgcc 189721 ttctaaaaac tccatcaaca gacctaagct gacttcaaat ttgcaccaca aggtgcactc 189781 tttaaataag aaaagagctc aaagagaaag agctggtctc ttgaagccag ctagatccag 189841 cgtaaattcg aaatctgggg aaataaaatc agtagcgttg gacctatact tccaaaacaa 189901 gaagaacgaa agtcagaatt ccactgctgt gacattacaa aatgcttcat cttctccggc 189961 ctccatcacc acgaggacac tttccaaaaa gagagctaag aaaatcgaga gaaacttaaa 190021 atatgctaca cagagaaaat tattggttga cgcaagcgct aagctagaag acgaaatgga 190081 tattgatcta gatggcggta agaaagtgaa agagaatgaa aagaagagtt ctttgacttt 190141 ggttaaggaa gccttatgga gtgtcattga cgatactgca tcccagggat tgatcatcga 190201 aaacggacaa ggcaccaccc tgggcggccc atttttccca tgagttaggc acttacgtat 190261 cttgtatagt aggaatggct cggtttatgt atattaggag atcaaaacga gaaaaaaata 190321 ccatatcgta tagtatagag agtataaata taagaaatgc cgcatatgta caactaatct 190381 agcaaatctc tagaacgcaa ttccttcgag acttcttctt tcatgaagga gataacatcg 190441 tgcgggtcag ctgcagtgaa aacactggta ccagcgacaa taacgttggc accggctttg 190501 gcggctttcg ggatggtctc cttgcccaaa ccaccatcga cttggatatt caaatggggg 190561 aacttggctc tcaaagtttc cacttttggc atcatgtctt ccatgaattt ttggcctcca 190621 aacccaggtt ccacagtcat aacaagagcc atatccaaat gaggagctag ttcaaataaa 190681 acgtcaacag aagtaccagg tttgatggcg catgcagctt tgatgccctt agacttaatc 190741 aacttaacta aatgcaaagg gtcttgtgtg gcctcgtagt ggaacgtaaa ttggtcagca 190801 ccacatttag caaaatcgtc gacccatttt tcaggatttt caaccatcat gtgacaatcg 190861 aagaacgcag tgggcttctt ttctgtgttg ctagcatcgc cagggcgtgg cacagaacga 190921 cgtagggagg taacaattgg ttggcccaga gtaatgtttg gaacaaaatg gccgtccatg 190981 acatcgatat gtaaccaatc tgcgccggcg ttgatgacct tatgacattc gcaacccaag 191041 ttggcgaagt cagaagcaag gatactggga gctataattg gtttgaccat tttttcttgt 191101 gtgtttacct cgctcttgga attagcaaat ggccttcttg catgaaattg tatcgagttt 191161 gctttatttt tctttttacg ggcggattct ttctattctg gctttcctat aacagagatc 191221 atgaaagaag ttccagctta cggatcaaga aagtacctat acatatacaa aaatctgatt 191281 actttcccag ctcgacttgg atagctgttc ttgttttctc ttggcgacac attttttgtt 191341 tctgaagcca cgtcctgctt tataagagga catttaaagt tgcaggactt gaatgcaatt 191401 accggaagaa gcaaccaacc ggcatggttc agcatacaat acacatttga ttagaaaagc 191461 agagaataaa tagacatgat acctctcttt ttatcctctg cagcgtatta ttgtttattc 191521 cacgcaggca tcggtcgttg gctgttgtta tgtctcagat aagcgcgttt gttatgcgaa 191581 aaaaaaaaac tttacagagg ctttgtttat atatagaaag accacgaaaa aaacagtgat 191641 ggcttcatgc ttttcagttt cattattggc acgagtagca gtcgttgagc ccatcagagt 191701 gcaactttgg ttaaatgtcg taaattgtat gattgaatca tccatgcacc aatgtcctcc 191761 acgggatcgc cacttttttt cttcatcacg ccccattttg ttgatccgac gttctgtatc 191821 aactgtatac agattcgttg cttctcgcac cacacaggtt ttacgtgcgg ccaagaccgt 191881 tgtcaagtgg ttcattattg tcgacccact gataaattct attctaatca attatctcat 191941 tgataggctc tgcactcttg ggcatgctgt attgcgagtg aaaaagcgca agaccgagga 192001 gagacaaccc tgttctccca ttatacaaca cacacacgtt aagagacgca aacggcctcg 192061 tctgaggatc gtagccatca agaggaagcg gaggcgtcga agaccacatc gcatcgagcg 192121 tccactctca aatatgtacc caataatgga aatccagatg gtggctgttc cacttgctct 192181 tcccagtcca actgcactgg tgcattatca gcagcagcaa cagcagctcc cgcaacatca 192241 tccctggtac gacctctcgc tttctgaaga agccctctcg acctgctgtt gtagttgacc 192301 tataactgaa aattcacacc cgcattaccc agcgcgcccg cacgtgctct ttatggaaac 192361 tataatgaat aacgaccaaa gaacatcttt ttttctctct cacacaaata aagcttttca 192421 tgtttataga tatatagcac atacttttac taagttttct agattgatta cgactcttcc 192481 agttgcacat tttttcatag cgaaagtaca agagtaggaa gagtggcaca atggcggttc 192541 aacaaagaaa gaagaaagag ggtagaaagt ccgataaaaa tgccccatcg gtcccacaag 192601 tagatgcatc attagacaaa ccacttgata ttgatgctcc tcctactatt tacagtgtta 192661 atttgaaacc agaatatggt acagctgcat tgaatttgtc cgcggatttc atcagacaag 192721 aacaggcatt ggctaataag tatttgttct tccatcccgt catccttgtt gttctaacca 192781 ttgggctgct tatttacttg acgccaagaa ttgtctttcc gataaggaat acaggatccg 192841 ttgctggatg gttctaccag ctggctcgta ttaataagaa ggtcgtcctc agcggtttag 192901 tgttcaccgc aattggtgca tctttcttgt tcaccctcct ctcacgtgta tctgactcgt 192961 atttcaagtc gaagatcaac caacttgttg gttctaaagg tgagaaagtt ttcggcatca 193021 atttgaatga tttggtggca agacatgaaa caaaggatcc agtggtgaac aatacgcata 193081 tcatcgttta tagagaaacg cccattgcat tgatttcgtt agcccctaac atgacattaa 193141 gtactgatga aaatttagtc atgagtgtta ctactgtggg ttgtcgtcgt gtatatgtaa 193201 aaagtggcat tatcgaagat ttgattgatt gggctatgct acactccaaa aatattagaa 193261 gcagcggcaa atacggggag accatgaaac tcttgattga tgtctactca ttcgatagca 193321 cgcttaagga aattttgaag aaaaaagggt tcacttatat tcaaagcatt agagtctctg 193381 aaaatcgact actaggcggt ttgttcggtg tgaagaagga attatggggt ttgcaattcc 193441 attttaaagc cgaacacaag gactaggata ctgttatttt tatagccaaa aaatgaaaaa 193501 aaacagcatg gcatcttgtt agttctgttg caactcgcag gaagtaacaa aataaacact 193561 ataatatttc catatattta tatatatgta tacaaacacc ttgttaacaa aaaaaaaata 193621 aacgaactaa agaaaaccgt aatgcagagt acaccttgaa gagagagaaa agaaaatctt 193681 tgaatccata gcataatagc gatcaacgaa actttttaag aagtaaaatg aactgaaagg 193741 agaaaaatat aacggaatcc caatgtataa taataaatag agagcggaag aaaaagaata 193801 ataaggggaa ttgagggtat caaaatacaa gacattcttt taccgaaaag aagaatgact 193861 taatagaaaa caaattcagc agatccagat aaaacagaaa ctgtgcaacc atcggaacca 193921 tctccggtga aagagccatc ttcatacgca cagctgccct gaacgttagc gccatcggat 193981 gcaactattt taacgttaaa gttggcagct tggttactgt tggggtttgg aatcaacgac 194041 aagtatgttt ctccattagt ggaaccagca cctaacacta gtggagccca gttgccgaca 194101 tccgaaccag aagtacccca aatgcaccca tcttctgcag atacaccggc gttgttaata 194161 tagtactgag cagaagtctt tttaccctgc cattgataat aagtgtcttc atcaacgact 194221 gaaattggtt gtgaatctcc accatcaacc actgtgggaa tcaccatgtt ttctgatcct 194281 gggtaatccg tcctacatag agcaatggag tcagactttt tgttaatggc cttagcagat 194341 gtttcatccg tagaacataa atcgctggta tcagtgttgg tacggtacaa gtaaccattt 194401 ttacagtaaa gaccaccaac agatttacca tcgcttggtt ggtcagaagg ccattgagtc 194461 tttgacattc caggttcaca tgcataagaa cagtagtagc catccttaca ttcggacgaa 194521 gtgttggcat ccatgtccat gacagaggcc catccaccaa atcctagcca gtccaaggaa 194581 actataccgt ttacagaagg gaagtccgaa catttgacag taccatcttg gaatccgcca 194641 tcacgcttct gttcagaggt atccttctca gatgaggaca atgtagtggt agtagcagca 194701 gattctacag tactagtagc ggcattggaa tctatgtatt gagtgacagt gacaaccgct 194761 ggtttttcat ctttgtgatg atcttcatgg tgactgtccg ctggagcagg tgcaggggca 194821 gaaaatgcga cagaagaaag ggaagacaat attaaagctg cggaaatttt cattatgtgt 194881 tagagagaga cgagttaagt atgtgcgact atactagtat tataatatta aaggaaagta 194941 aggtaccgtc tatgaggaga ctgttagttg gatatcagta atgagacgaa aaagctcgaa 195001 atgaatggat atattctttt tgctactggc aactgttgaa tatttaatgt taaaacaaac 195061 taactgaggt atattcgtat ctgtatgtac acatatacta tatacaggaa aagataagca 195121 agagagagga tatcaactac gagagcgatc gattatatat caaaagctgt ccgctttgcc 195181 acccataatc ggcgcttagt ttcggagttc aatcataatt ctaccacctt acactcaact 195241 tactctttaa ctcctatagt ataatatcgc cactgacccc atattaaaaa aatttttttg 195301 ctcgatcttc tatcctcttt aggttaattg tcgctgttat tgtctagatt ttttctcgga 195361 gatggcgcat ctatttgccg tcaaaagatc ctctcatacc atattaagta aattgcctcc 195421 atttcttttt cctcgggcag agaaactcgc aggcaacttg ctctcgaagt ggtcacgtgc 195481 gggtctaggc ctgcataatc ggccctcaca gagggatccc gttacccatc tatgctgaag 195541 atttatcata ctattcctcc gctcgtttct tttttcagtg aggtgtgtcg tgaaagaaaa 195601 cccacaatta aactttcaac aaccgggcga ctaggaagag agtagtgggc gcggatgacg 195661 aaggctaagg tcacttcttc gtttccttta ttggggtttc cgtgtagcct tcccctgaat 195721 agtgtgggac gttttatgag aagccgtaag aaataggcaa attgagttat gacaagtaga 195781 catgatgccg cagccttgcc tgactttacg tctccttcat gaataagttt ttctatcgag 195841 ttcttttcct tttttcgcct taattagctc aattaagcct gtcctcacta cttttctttt 195901 tcttatcggc tttgtgccac acctaacctt cgaatgctgt tttattccgt tcttacatgg 195961 gatggtaatg ccttggcgag aatttcgatt ttcaggatat tgtcttggtg gcgtcttttg 196021 ctgttactat gtgtttaaga gagagctgtt ctacaaagaa cttttcattt acgcgttttt 196081 tccttttttt ttttttctca tcctaaacgc gtaaatctgt tccctttttc atgtaatggg 196141 cgtacaaccg acgatggaaa aatgaatctt gcaattttaa tactaacact tggaataact 196201 ccaaacaggt aagaggctca cagaatctcg aaagtgtaac agcgtactct ccctaccatc 196261 caattgaaac ataagatata gaaaagatgt caattgtttc actgttaggc atcaaagtct 196321 taaacaaccc ggcaaagttc actgatccat atgagtttga aatcactttt gaatgcttag 196381 aatctttaaa acatgactta gagtggaaac taacctatgt tgggtcctct cgttctctag 196441 accatgacca ggaattggat tccattctgg taggccccgt tcccgtaggt gttaataaat 196501 ttgtgttttc tgctgaccct ccctccgccg agctgattcc tgcgagtgaa ttggttagtg 196561 tgactgttat tctattaagt tgttcttatg acgggagaga gtttgttagg gtcggttact 196621 acgtgaataa tgagtacgat gaagaagagt taagagaaaa tccgccagca aaggtacaag 196681 tagatcatat tgtaagaaat atactggctg aaaagccaag ggtaacaagg tttaacattg 196741 tttgggataa tgaaaatgaa ggggatttat acccacctga acagcccggc gtagatgatg 196801 aagaggagga ggacgatgaa gaagaagatg acgatgaaga tgatgaagac gacgaagatg 196861 acgatcaaga agatggagag ggagaggcgg aagaagcggc agaggaggaa gaagaggagg 196921 aagagaagac tgaagacaac gaaacgaatc ttgaagaaga ggaggaagac atagaaaata 196981 gtgacggcga tgaggaagaa ggagaagaag aggtggggtc tgtagacaag aatgaagatg 197041 gtaatgataa gaagaggagg aaaatagaag gggggtccac ggatattgaa tccactccaa 197101 aggatgcggc acgttcaacg aattaagaat ttatgggtta taagattaat ggtacctgca 197161 agagaggtac actttataaa atgtataaat aaaaaaataa cagacataag ataaagtcgg 197221 gttagggcaa cagctacgta aaaaataaaa ggcagtaata ttttccattt aagttgattt 197281 tcttattatt gtcgttgaga acaaaaagaa attggacgag tccggaatcg aaccggagac 197341 ctctcccatg ctaagggagc gcgctaccga ctacgccaca cgccctaata ttattgatat 197401 tgttgtttat caaagtgaga tacgtcagta tgacaatacg tcatcctaaa agttcataaa 197461 acacatatga aacaacttca taacagaacg aacatgttgg aataaaaatc cactatcgtc 197521 tatcaactaa tagttatatt atcatgttgg aacgagagta attaatagtg acatgagttg 197581 ctatggtaac aatctaatgc ttacatcgta tattaatgta caactcgtat acgtttaagt 197641 gtgattgcgc ctattgcaga aggaatgtta aacgagaagc tcagacaata ctgaagctgt 197701 gttaaagacc tattagttga acatgttatg gtaggtacat atatgaggaa tatgagtcgt 197761 cacatcaatg tatagtaact accggaatca ctattatatt ggtcataatt aatatgacca 197821 atcggcgtgt gttttatata cctctcttat ttagtataag aagatcagta ctcacttctt 197881 cattaatact aatttttaac ctctaattat caacatggcg accccagtga ggggtgaaac 197941 aagaaatgtt attgacgaca acatttctgc gcggattcaa tcgaaagtca aaacaaatga 198001 tactgtcaga cagacgccat catcattaag aaaagtttct attaaagatg aacaggtgag 198061 acaatatcaa agaaacttaa ataggtttaa aaccatacta aatggtttaa aggcagaaga 198121 ggaaaaactt tctgaggctg atgatattca gatgctagct gaaaaattat taaaactcgg 198181 agaaaccatt gacaaggttg agaataggat tgtggatcta gttgaaaaga tacaattatt 198241 ggaaacaaac gagaacaata atatattaca tgaacatata gatgctacag ggacttacta 198301 tttattcgat acgttaactt caaccaacaa aagattctac cctaaggatt gtgtttttga 198361 ttataggact aataatgtcg agaacattcc tattctctta aacaatttta aaaaattcat 198421 caagaaatat caatttgatg atgtctttga aaatgatatc atagaaatcg atcctcgtga 198481 aaatgaaatc ttgtgcaaga taatcaaaga aggactcggt gaaagtttag atatcatgaa 198541 cacaaataca actgacattt ttaggataat cgatggttta aaaaaacaaa tatagaagtt 198601 tgcatggtag agatgtcaga attagagcct gggaaaaggt tttggttgat acaacatgta 198661 gaaattccgc attgttaatg aataaacttc aaaagttggt actaatggaa aaatggattt 198721 tttctaaatg ctgccaagat tgtcctaatc taaaggatta cctacaagaa gctatcatgg 198781 gaaccttaca tgaatcctta agaaattctg tgaaacaacg tttgtacaac attccacatg 198841 acgtaggaat tgatcacgaa gaatttctaa tcaatactgt tattgaaaca gtaattgatt 198901 tgagcccaat tgcagacgat caaatagaaa atagctgcat gtattgcaaa tctgttttcc 198961 attgctcaat taactgcaaa aagaaaccaa atagggaact taggcctgac tcgaccaatt 199021 tctcaaaaac ctattatcta caaggtgcac agagacaaca accacttaag tccagtgcaa 199081 aacgaacaaa agtcttggaa caagacacaa aaaaggtcga acaaagtgta caacagcaaa 199141 aaactggtaa ttattgatac cggttccgga gtaaacatta ccaatgacaa aaccttactg 199201 cataattacg aagacagtaa tcgcagtaca cgattttttg gtattgggaa aaacagttca 199261 gtgtctgtta aagggtatgg ctatataaaa atcaagaatg gtcacaacaa tactgacaat 199321 aagtgtctat taacttacta tgtaccggaa gaagaatcca ctataatcag ctgttatgac 199381 ttagccaaga aaaccaaaat ggttttaagt cgaaaatata ccagattggg aaacaaaatc 199441 ataaaaatta aaaccaagat agttaatggt gtcattcacg taaaaatgaa cgagttaatt 199501 gaacgtcctt ccgatgattc aaaaataaat gcaataaaac ctacttcttc tcctggattt 199561 aaactaaata aaaggtctat taccttggaa gatgctcata aaagaatggg ccatacagga 199621 attcaacaaa ttgaaaattc cataaaacat aatcattatg aagaatccct tgacttaatc 199681 aaagaaccaa atgaattttg gtgtcaaacc tgtaaaatct ctaaagccac gaaaagaaat 199741 cattataccg ggtctatgaa taatcatagt actgatcatg aaccaggctc atcatggtgc 199801 atggatatat ttggccctgt atcaagttca aacgcggaca ctaaaaggta catgcttatt 199861 atggtggata acaacacgag atattgcatg acctccacac acttcaataa gaatgctgaa 199921 actattttag ctcaagttag aaagaatatt cagtacgtgg aaacacaatt tgacaggaaa 199981 gtcagagaaa ttaattcaga cagaggtact gaattcacaa atgatcagat agaagaatat 200041 tttatttcaa aaggaataca tcacatactt acttctacac aagatcatgc tgctaacgga 200101 agagcagaaa gatacataag aacaataata actgatgcaa caacactcct aagacaaagt 200161 aacttaagag taaaattttg ggaatacgca gtaacttctg ctaccaatat aagaaattac 200221 ctggaacaca aaagtacagg taaactacca ttgaaggcaa tctcacgtca acctgtgaca 200281 gtgagattaa tgtcattctt accatttggc gaaaaaggaa taatttggaa tcataatcac 200341 aaaaaattga aaccatctgg acttccttct ataattctat gcaaagatcc aaatagttat 200401 ggatacaaat tctttatacc atccaaaaat aaaattgtca catctgataa ttatacaatt 200461 cccaactata caatggacgg tagagtaaga aatactcaga atattaacaa gagtcatcaa 200521 ttcagttcag ataatgatga tgaagaagat caaatcgaaa cggtcacaaa cttatgtgaa 200581 gctttggaaa actacgaaga tgataataaa ccaattactc gcctggaaga tttgttcaca 200641 gaggaagagt tatctcaaat agactcaaac gcaaaatacc catctcctag taataaccta 200701 gaaggggact tggattacgt attttctgat gttgaggaat ctggagatta tgacgttgaa 200761 tctgaacttt caacgacaaa taattcaatc tcaactgata aaaacaaaat tttgtcaaac 200821 aaggatttta attcagaact tgcatcgact gaaatatcca tcagtggaat cgataagaaa 200881 ggattaataa atacaagtca tattgatgaa gataagtatg atgaaaaagt ccacagaatt 200941 ccatcgatta tacaagagaa actggtagga agtaaaaata ctattaaaat caatgacgaa 201001 aacaaaatct ccgacagaat tcgtagtaaa aacattggga gtattttaaa cactggactc 201061 agtagatgtg tagatatcac cgatgaatct attactaaca aagatgagtc aatgcacaac 201121 gcaaaacccg aactaattca ggagcagtta aaaaaaacaa atcatgaaac ttcgtttcct 201181 aaagaaggga gcattggaac aaatgtaaaa ttccgaaata caaacaatga gatttcttta 201241 aaaacaggcg atacgagttt accaataaaa actttagaaa gcattaacaa tcaccatagt 201301 aatgattatt ccacaaacaa agttgaaaag tttgagaagg aaaatcatca tccgcccccg 201361 attgaggaca ttgtggatat gagtgatcaa actgatatgg aatcaaactg tcaggatggt 201421 aataacttaa aagaattaaa agtcaccgat aaaaatgtac caactgacaa tggaacaaat 201481 gtgtcaccaa ggttggaaca aaatattgaa gcatctggat caccagtaca aacagttaat 201541 aaaagtgcct tcttaaacaa agaattcagt tctttgaaca tgaaaagaaa acggaaaaga 201601 cacgataaaa acaatagtct aacaagctat gaattagaaa gagataagaa gcgttcaaaa 201661 aagaatcgag tgaaattaat tccagataat atggaaacag tttcagcacc aaaaattcga 201721 gccatatatt ataatgaagc tatttcaaaa aatcctgacc tcaaagaaaa acatgaatac 201781 aaacaggcat atcataaaga attacagaat ttaaaagata tgaaggtatt tgatgtcgat 201841 gtgaagtaca gtagatcaga aatccctgat aatttaatag tacccaccaa cacgatattc 201901 acaaagaaaa gaaatgggat ttataaggct aggatagtct gcagaggtga tactcagtca 201961 ccagacactt acagtgtaat aactacagaa tctttaaatc acaatcatat taagatattc 202021 ttaatgattg caaacaacag aaatatgttt atgaagaccc tggatatcaa tcatgcattc 202081 ctatatgcta aattggaaga agaaatatac atcccacatc cgcatgatag gagatgtgta 202141 gtcaagctaa ataaggcgtt atatggtcta aaacagagtc ctaaagaatg gaatgatcat 202201 ctaagacaat acttgaatgg aattggactg aaagataact cttatactcc gggattatac 202261 caaaccgagg ataaaaatct aatgattgca gtctatgttg atgactgcgt aattgcggca 202321 agcaatgaac agagattgga tgaattcata aacaaattga aaagtaattt tgaactgaaa 202381 attacaggaa cattaataga cgatgtactc gatacagata tattaggaat ggatctagta 202441 tacaacaaaa gacttggtac tatcgattta acattaaaat cattcataaa tagaatggat 202501 aaaaaataca acgaggaatt gaaaaagatt agaaaaagtt caattccgca tatgtcaact 202561 tataaaatag atcctaagaa agacgtactg caaatgtcag aagaagagtt tagacaaggt 202621 gttctaaagc tacaacaatt actaggtgaa ctaaactatg tcagacacaa atgcagatac 202681 gacattgaat ttgctgttaa gaaagtggct agactagtaa attacccaca tgaaagagtc 202741 ttttatatga tttacaaaat aatccagtac ttggttcggt ataaagatat tggaatacac 202801 tatgaccgag actgtaataa agacaaaaag gttattgcta taactgatgc atcagttgga 202861 tcagaatatg atgctcaatc aaggattgga gttatattat ggtacggtat gaatattttt 202921 aatgtttatt ctaacaagag cacaaacaga tgtgtatcat caacagaagc agagcttcat 202981 gccatttatg aaggctatgc agactcagaa acgttgaagg taacattaaa ggagctagga 203041 gaaggagaca ataatgacat tgtcatgatc actgactcaa agccagccat tcaaggatta 203101 aatcgcagct atcaacaacc aaaagagaaa ttcacttgga taaaaactga aataataaaa 203161 gaaaaaatta aagagaagag tataaaactg ttaaaaatta ccggcaaagg taatattgct 203221 gatttactaa caaaaccagt atcagcatct gattttaaaa gatttataca agtattaaaa 203281 aataaaataa catcacagga tattttggcc tcaacagact attgataatt aattaatgaa 203341 gttctaaaca cacaatgaat atctgttgaa gtacaataat atatctttaa gggagcatgt 203401 tggaacgaga gtaattaata gtgacatgag ttgctatggt aacaatctaa tgcttacatc 203461 gtatattaat gtacaactcg tatacgttta agtgtgattg cgcctattgc agaaggaatg 203521 ttaaacgaga agctcagaca atactgaagc tgtgttaaag acctattagt tgaacatgtt 203581 atggtaggta catatatgag gaatatgagt cgtcacatca atgtatagta actaccggaa 203641 tcactattat attggtcata attaatatga ccaatcggcg tgtgttttat atacctctct 203701 tatttagtat aagaagatca gtactcactt cttcattaat actaattttt aacctctaat 203761 tatcaacata tcaatatatt attgaagatt gggtgaattt tgagataatt gttgggattc 203821 catttttaat aaggcaataa tattaggtat gtagatatac tagaagttct cctccaggat 203881 ttaggaatcc ataaaaggaa atctgcaatt ctacacaatt ctataaatat tattatcatc 203941 attttatatg ttaatattca ttgatcctat tacattatca atccttgcgt ttcagcttcc 204001 actaatttag atgactattt ctcatcattt gcgtcatctt ctaacaccgt atatgataat 204061 atactagtaa cgtaaatact agttagtaga tgatagttga tttttattcc aacaattatc 204121 atatacggtg ttaagatgat gacataagtt atgagaagct gtcatcgaag ttagaggaag 204181 ctgaagtgca aggattgata atgtaatagg ataatgaaac atataaaacg gaatgaggaa 204241 taatcgtaat attagtatgt agaaatatag attccatttt gaggattcct atatcctcga 204301 ggagaacttc tagtatattc tgtataccta atattatacc ctctatcaac aacaggattc 204361 caacaattat ttcaaaatcc acccatatct cagatttcac atcagtattg attaaaatat 204421 taattgctac cagttctaat aaatctaatg tttacatcat atagtaatat atcttttgag 204481 aaatgtgact ggcgttatac agaaaccgaa ttacacgttt taaatactaa ttattaaaat 204541 ttatcctgat aagttgatct ttatttccgt acagcacaac cgatagagga gatgtttaaa 204601 gtgtttaagc tcactttata gggtgaaaca cattttgacg accgtaaaag gtcatttgat 204661 ttggtattga ggtcgagaaa atattttcaa atagtgaagg atacattaaa cacgctcaca 204721 aaacaacata aaaatccgtg atagtttaat ggtcagaatg ggcgcttgtc gcgtgccaga 204781 tcggggttca attccccgtc gcggagattt tttttggccc ttgatgactg ttctggtaca 204841 atttccacct tgaatgaggg tataagatac cgatgatata tattcagact atttctacga 204901 cacagaaaaa caatcgacca agccgtcctt gaacatgctg cagaacttcc ttttttttat 204961 tttttttggc tcatctacgt aatcctatta tcttttatta aattttgaag ctatgagttt 205021 ctttccagcg acttggaacc aatagttgac agtgagtgca tacttgagta ttttccccct 205081 acattgtaca gtcctcctca gacctggtat ccctgtttaa tgtggtcgct catcggactt 205141 ttccgtccga taggaattcg ctcaactttg acaggcggaa ctactttcac atcgattttc 205201 tcaggaaaga cggcgtaaac aagagaagaa attaactttc tacagaaagt acaaccatat 205261 aaacccttcg tagagctcca attagtagca aataatgaca aataatgtca gtgaacgacc 205321 aaataactca tataggaaaa acattgtcca caacggcttc cgctttttta aactaccaaa 205381 aatcgaacag caacactcaa gatgtactga ccaataatgg gccttataag aatttattat 205441 caaataccgt caacaatgcg agctcaactt catactttta caagaggact gaacacggtc 205501 gctttgtaaa aaatgcatct aacacttttg aggatattta ctccaagaca agaaggggcg 205561 atgtattcag gaacaagttc acagacaaca aaacatgctt cagaatgctc acgtacataa 205621 gtgatgattt gttgaacgag atcccaacta aggaaggtct caaaagtgat gcagatggca 205681 agcttctaac cgaaggaggc gaaaatgaaa atctcaggaa gaacgcatcc aaaaaagaaa 205741 catcgctgtt tcagggcttt aaaagctacc taccaatagc ggagcttgcc attgaaaaca 205801 ctgaaagatt aaactatgat acaaatggta caagcggtac ggttggtgcg aaagatgtta 205861 tgtctaaaac aaatgagcga gatgaaattc acacagagct tcctaacttc caagattcat 205921 ttctcatacc gcctggggta gaaactaaaa aaataagctc ctcttattct cctagtgcat 205981 taaaaagttt ttctcaaact cttgtaaata gtttagagtt tttaaatatt cagaaaaatt 206041 ctacgttatc cgaaataaga gacattgaag ttgaagttga gaatctgaga caaaagaaag 206101 agaaactgtt gggtaaaatt gcgaacatag agcaaaatca attactattg gaagacaacc 206161 tcaaacagat tgatgatagg ttggactttt tagaagagta cggattggag gtgatcgaag 206221 ctaatagcga cgaaaatgca gaagatgatg gtatgagtga gcgaaaggcc cttaaaaatg 206281 atgctataag aaatgagggt gtcaccacag agagcatatc atcagaggct tctaatctac 206341 ctccaaggag aaggcaacaa cttcgagacg ataactcatt gaatagatta ggtgcctttt 206401 atagcaaatc caaaaaaaga cacagaaaaa gcttcccaac attccagcag ctttacgagc 206461 caggaacaaa aattggctct ataatgtcca ctcacgatga tttcctcact tgcctagatt 206521 ttgatgcgcc ctttggtacc ttatgtacag ccggatatct tgatcacacg gtaaaaattt 206581 gggatttatc caaacaaaac aaaattggag aactagcagg acatcttgct acaattaatt 206641 gtatgcaaat caatcgtgac tacggaactc ttgttactgg tggtagagat gcggctttaa 206701 aattatggaa tttgaattta gctcaacaac tttaccagga aacgcaaaat cttacctctc 206761 ctacaaatca tattgattct ccatgtgttc atacatttga ggcgcataca gatgaggtta 206821 ctgcattatc attagatcct agtttcttgg tgagtggttc acaggataga acaattaggc 206881 aatgggactt acgttccggg aagtgcttgc aaaccattga tctgagcttt gcaaatgtct 206941 taacaacatc cactaatgtc gatttatcaa agagcacact tcttactcaa agaaatgaga 207001 ggcctagtat aggtgcacta caaagttttg atgcagcgct agcaacgggt acaaaagatg 207061 gtgttgtaag gctatgggat ttaagatccg gaaaggtgat tcgtactttg aaagggcata 207121 cagatgccat aacgtcatta aaatttgatt ccgcgtgcct ggtcacaggt tcatacgaca 207181 gaacagttag aatctgggac ttaagaactg ggttgttgaa taagtttcat gcgtacagtg 207241 cgccagttct ttcgttagat ctcttccaag agaacgctgc agtcgttgtc gcagacgaac 207301 caagtgtcca gatatacgat agcgaaaagg atgaaagctg gtcttgcgtc gaacaaggta 207361 acgagactag cgttagtacc gttaagtata aagaaaatta catggttgag ggtcgtgaaa 207421 atggggacgt aaatatttgg gccgtatgat aggcattgca ttgcaatcaa gtcaacccat 207481 ttgaagaaaa ataaatatcg agtgcatatg tgaatagctg ctcgctcaga tatatataaa 207541 taaatattcg ttctggaatg taaataaagt atcgtcaata ccttggatgg tttatcagcg 207601 aaatcggtgc tgtagatgtt gccctgtcat attactacag atgtcttgga agcaatcacc 207661 atacctgcat tatccttacc cggaaaaaga aaactttcgt gaataatgat taatatttaa 207721 gtggcgactt tttcatcctt gctattgaaa aaaaaaaaaa tgaataattg ttattaagcg 207781 ttagcagatg ccaaattgtc gaaatgattt caaatacaga gaattagccg caaatattaa 207841 gtagtacctg aatcacgaga catacaactc ggaaaaatga actttggaag ccaaacacct 207901 acaattgtgg ttctaaaaga gggaacagac gcatctcaag gtaaaggtca aatcatctct 207961 aatatcaatg cctgtgttgc agtccaagag gcattgaaac caactttagg tcccttaggt 208021 tctgatattt taattgtgac atcgaatcaa aagactacta tttctaacga tggtgccacg 208081 atcctaaaat tattagatgt agtacatcct gctgccaaaa ctttagtgga tatttctaga 208141 gctcaggatg ccgaggtggg tgatggtaca actagtgtaa ccattttagc tggtgagtta 208201 atgaaagaag ccaagccctt tttggaagaa ggcatttcat ctcatttgat tatgaagggc 208261 tacagaaagg ccgtttcttt agctgtggag aagattaacg aattagctgt ggatattact 208321 tcagagaaaa gcagtggcag agaattactt gaacgctgtg ctagaactgc aatgtcgtcg 208381 aaattgattc ataataatgc agattttttt gttaaaatgt gtgttgacgc cgtgctatcc 208441 cttgatagaa acgatttgga tgacaaatta ataggtatta aaaaaattcc aggtggtgct 208501 atggaagaat ctcttttcat caacggtgtc gcctttaaga agacattttc gtatgctgga 208561 tttgaacagc aacccaaaaa gttcaacaat cctaaaattt taagtttgaa tgtagaactg 208621 gagttgaaag cagagaaaga caatgctgaa gtacgtgtag aacatgttga agattaccaa 208681 gctattgtag atgcggagtg gcaattaatc tttgaaaagc taagacaagt ggaagaaaca 208741 ggtgccaata ttgtactatc aaagttacct atcggcgatt tggctactca attttttgct 208801 gatagaaata ttttctgcgc tggtagagtg agcgcagatg atatgaatcg tgtcatccaa 208861 gctgttggag gctctataca atctactact tcagatataa aaccagagca tttgggtact 208921 tgtgctttgt ttgaggaaat gcaaatcggg tcagaacgct acaatttatt ccaaggttgc 208981 ccacaagcta aaacatgtac attattatta agaggaggtg ctgagcaagt tattgccgag 209041 gttgagagat cattgcacga tgcaatcatg atagttaaga gagcgttaca aaataaactg 209101 atcgttgctg gtggtggtgc tacagaaatg gaagtatcaa aatgcttgag agattattca 209161 aaaaccatag ctggtaagca acaaatgata atcaatgcct tcgctaaggc tttagaagtt 209221 attccaaggc aactctgtga aaatgctggg tttgatgcta tagaaatatt aaacaaacta 209281 agattggctc acagcaaagg tgagaaatgg tatggtgttg tctttgaaac agaaaatatt 209341 ggcgataatt ttgccaaatt cgtatgggaa cctgctttag taaaaatcaa tgctttgaac 209401 agtgccacag aggctactaa cttgatttta tctgttgacg agacgatcac taataaaggt 209461 agtgaaagtg ccaatgctgg catgatgcct ccccaagggg ctggaagagg gagaggtatg 209521 ccaatgtaat taacactcta aaaaacatgt gctgcataca ttttattatt actctttttg 209581 cagtagttat ttgcatcaaa ggtaatttct ttcaatcata aataagttaa tactgtattg 209641 ataaaacctt attcttttct tttgtatact ctgtatctta aagtaattct aggtctaaag 209701 aaaaatgaaa gaagtaatga aaactccgag aaacaaatca tatcattggt cgtcatccgg 209761 gttggatgtc atgcagctgc attccatttc ttcggcaaaa tgtacgtaat attcgattag 209821 aaccctgttt tgcaactgat tatgctacta tgtatttata tatgcataca tatgatgata 209881 ttatatttga aaaatgatgc tgattttttt gaaaaaaaga tctatcctcc tttattccct 209941 tcttgtttta ctgtcctttg caaacgttcc tcaagagctc gacatttccc gtctaattca 210001 ttgatatgtc tcctatataa atctgtaaca agttctaact catttattct agttttgagc 210061 tttataattt cttcttcttt gtgcaattta gtggataact gatcacctaa atctttagct 210121 gggtgatttt caaattttcg tccagaaaca tcagaactag aaacactatt tgagatggat 210181 tgtgaatttg ctttggatat acagggagct ttagaagatt gtagaaacgg tatgaaatga 210241 ggcggtgtcg tctcggtttt cacgttgcta atcgcacgat ctctcgtctc aagcatgtcg 210301 ttaatagaag ccatgtggaa agataaaggg gctgggtcgt tacgcttagc agatattata 210361 tctggggaag acatcgtcga tctaatttga ttcggtacct cggatggatt agagtcagtc 210421 gtccgtgaag aagtgggtgc cagagttgcg gcggtagagg caataccatt attgcaattg 210481 gacactattt cacttccgtt atttgatatt gaagtactgc tcaagcttcc aagcagcatt 210541 gataagtgag gtaattgagg agaatctgcg cctgtttttg atgttactga atgtgaagca 210601 ttgaggggga aagaggctgc gttgaattgc gaccgttctt tgataaaagc agattggtgt 210661 gcagaatttg aatactcttt aacgtccgta taacttggga acgtaagtaa cttctcttgg 210721 tatatagcag tatcttgttt gggcagttta ggctttaagt ttggtctcga acaatctccc 210781 gacatcagta cctctaattt tgttgctgat aggtgagaat cgcttctttc cttagactcc 210841 gtttttggct tcttggatat cttcgcagta gatgatgttc ccattaaaag ttgcgaactt 210901 tttttctttt tatcttcaga tgttactctg ttagctttgc gaccgcttga ttctatatta 210961 caatcaccct taagctctgc aatcagcgtc tgattccgaa agttgtccag attatgtgca 211021 tgatttgtat tacttttcct atttcgagac tttattacat cagttttcaa actaattggc 211081 ctgggtttcc catgaagctt taaaaagaga ccacacgcat tacaaagcat agctccatgc 211141 tcatctcttc tccataatgg tgttgtagag gttaaacagt tcttacaaac aggaacatta 211201 gcatcattgg atacgttatt attgcaattg gcatccattg tttgtccatt attcttaact 211261 tgatttttag gtaatatatg gtgtaatgaa ttcgtatccg gactcattct tccagcagta 211321 gatgtggaaa aagacttgtc attcgcctta aaattcatat tgttgcttat tgacgctcct 211381 gcttgcgatt cacgcaattg aactgccgat ttttgctcgg cagatactgc ttcataacct 211441 aaaggtggcc atctcccaat atgcccttct tcttcgcttt gatttaagct gttgaggttt 211501 tcacttgatt ttggttcaaa tacattatct cgttttctaa tgttatagcc tcgaagagtt 211561 gtagcctgcg atgccataat attaccagta gaattgtaga gcacagtaca aatacccgaa 211621 atgatattcg tatatctagt attatagctt caaccgcttg caatatgttc tctttcaaac 211681 taccttatta tcaagcctat atcttatttt tcactgatta ggattgataa gcgcagataa 211741 gcgaagataa gaaaattttc actctgttcg cccgctattt aggatcagta attttagtaa 211801 cgttaatcac taggaacgac gagaaagatg acagaataat atctcattga aacttgaagt 211861 agcgtaattg aaatattaag ttcaaactca gaaaggggca gctatcacga atgaataaca 211921 atattttcaa tgaaagattt cgttcaacag catagtgttt tactttacaa aaatttacat 211981 aatacttcac cttttttttc taatctaaat acctatcaaa aggttcccct aaaacgtttt 212041 caacaacctt gaccaaaccg gtcctgactt cacgttcgat ctcttcatca tcatcttcca 212101 ataactcagc gatgacggga acgagctgtg gcaatagaac taaccaactt tcacctatct 212161 ttgagtatat caacttcatg gctctaatag cccataattt ttcattggag gaacaggaag 212221 ctttcatgtg ttcaacgatt agtttattca aaatttggtt atgctcatca acgccactat 212281 tgttagaagc cagagcgcca attgccttga ccaggtactt cccaatagag ttttctatat 212341 tagatagttg attgaccaag gatacagaaa ttaactcgaa tctggaagtt gatttccagt 212401 attcgtctct atcaaacttt agcgaagagg ttagagagtt gattaccaaa cgtcttaaat 212461 taacgttttc catgtccttg ctaatgaatc tttttaacaa catatcaaca ggttctaaca 212521 aatacgtgaa ataggaagta attatacctc tcaaattttc ttgaagcttg ttgaaaaatt 212581 tgaaaaatgc caacagtctt tctgtttcag tgatacctgc atttgtaacg ccttcaccgt 212641 caaacgccca tcttactaat ataacaaata gcggtctaaa tactttgtca ttcatcttca 212701 ggacgtaaga gttggaaatt tcgtgaacgg atgcctctat cctactaatt gtattattat 212761 cgaaactgga aatggatcta aattcgaata aagataatag taacttaaaa aatattggcg 212821 attgtgaggt tgcggatttt ttatcaatat tttcaacagt ggattctaat gtactcaaaa 212881 atagactaac agcaactgta tcattggacg ttgctatttc agtggaccaa attctgaata 212941 aaactttcaa aacttccttc aaatctatat tctcaattat caatgaaatt actgacagcc 213001 taatgctgct gtcaacttca cgggaaaaat aaataacatg caaaacatcc aaaatatttg 213061 acatcaagaa acttggtatc cttttgatta gaccggcgaa cagcaacagt atagcaactt 213121 gcaactgctc ttttaatggg ttactactat ctgccaatga agcatcaaat aatttaatag 213181 aaggtgggac tatttttgga tagaacgcaa ttgacttgac tcctaaaact tgaacacagt 213241 tagttatcaa tgccaacgaa gatatcttga cctctgtcat atcagaacta actttttcag 213301 tagcaagggt gagggcttga gttaatatgg acccctcaag cttcttacca tatttgctca 213361 ctaaagccgt catcgtgttc aatattactt gagaaataac aacagattta gattccaaag 213421 gcattctgtc gagcaaaacc ttcatcacat tgttaactat aggaatagct tcagagcctt 213481 ctaactcgaa tttggaccct attaccaacg ttaggtggta tctaatatct tcattagtgg 213541 atgtactgag taagggtaat accgcattaa caaactcgtc aactggtaga atttgtaaca 213601 cattgccaag caccttgaat agaatctcct ttatttcagt cgtgtgatct gataatgatg 213661 tttcagagtc ggaagcttcc tcattttctt gggaagttat acatgaaaag gttaattcta 213721 cagaattaat gaaaaaaaga acaccttcta aaagggttcc aaattcttcc ctgatgtttc 213781 taattaactt tttatcgctt gtttcatcta acaaaacaga atataccttt agtcttaaat 213841 ttctcctcac atcgtaataa tcttgatctg tttcctcggt tattttattg ataaactcaa 213901 aggtattgtt cataaatgtc aaaaattcac tttccgaaaa attcaagaca ccatttgaaa 213961 acaagacacg ggattctagt gatttcttct tttccgagga gctctttgat gatgtcaaca 214021 atttgatgat atcgagtaag tcattcaaac ctgataattc ctcattgaca tgtagatcaa 214081 cgagtagggc cttaataaac tcaattaata ttcttgcctc gccaatttta aagttgacta 214141 aagctgaaga atactgttgt gcaatcaaga aaaggaacga gcccagtgcc tttactggat 214201 caagtgtttt gattaacgta gaaaataatt taaccctcct atgtcttgga acatgttgca 214261 aagcggttgt gaagctcaac aaaaggaact ccatttcctc tttttcattt cctttgctat 214321 tcttgatcaa ggcagggaca acagttagta tcgtacgctc aacaacttta gttgtgaatt 214381 catcatcttg acgaatacta tgggctccca taaaagtaaa gataggcatt acagaatgca 214441 aaataacttc cgaacttaaa gtagcaagag atccaattac aagtaatagt ttgttttgga 214501 cttgcggaga tgcagaattt ctaatagcgg ataccaatat atctgccctt acgttggtta 214561 gttctgtaca gccatgttcc ttcaagtatg tgatagtgtt cagcgtacaa gaaatcaaag 214621 tttcttgcgc atataaaacc ggtaatccac cgtcttgatc caaagtttcc agatctgata 214681 ataaggaaag taaagtgaac aaaagctttt cggatccaac atttctgact ttatcaagtg 214741 cttccaaaat aatcgtcaac tttctcaggt gcaattccgc cagttgcgaa acctcctctt 214801 tcaaaaatgc gtttttactt gttgatgaac gtcttcttct tcttttagaa aagtctgtct 214861 gatccatttc gttactgata ctgttttgat ttagtatgga tacaaaaata tcggaatcta 214921 acggcaatga ttgtagtaca ccgactgtat cgtacgatga ttctacgtta ctcgaagaat 214981 ccacgatatt ttggacgatt tttagttttt gagcattatt taatgaagcg aatatgctga 215041 taagcctctc ggcagctatg ttagctaact gctcataatc tgagttaaga gcactgagaa 215101 caaaatcgat catgaatgac tgcttttctt ttggtgatac caaattaact aaagagcgct 215161 caaaatgctc aaagtttgtt ttattagcaa tacaactctt ttcccaacta gatctgtttt 215221 ctaagtagtg ggaaataaat tcctcaaata gggaggaata agaagatgca taagtcggac 215281 tcttgttcag gttatccaac aacactgtct tggcatacgg agaaggtatt agtagggctt 215341 gattagccca aaacatcaaa aagacttttt catttctctt tggcgttaaa attctggata 215401 tgtcataatt ctcagtaacg tactcattca aaaatcctga taaccatgcc tcactatctt 215461 tgggatttaa cataggaatg gtaacgttct ctccgtaaag tttatcagac aaaaagtagt 215521 gcttagtgga tggtctttta gcaatcaagg aaagaatctt cttcacgcca gtcctaactt 215581 ttatagaagc atctcgcaaa gcgcaaatca agcatggaac taaagtaaaa atattaactt 215641 ccttttcaat actattaata tattttgcaa tattgtttaa agatattagc tttagcgcgg 215701 ttggagcggc tggagatata gttactctta acaaaaacgt tattcttgat tctaaagtag 215761 tgaaaaatga agtcaagaag gaacttgctt tatagccttt accaatagct tcagtgaata 215821 aagataaaac ctttttgtat ctttctccag tttctgttag catggacaca ttcgttgtgt 215881 ttatcaattc tgaatgctta tccaagaatg tttgaaatga agcggtatcc tttttagtag 215941 tttccacggg gtcgcttaac tgctttacaa tgtcggtgtt aacatcggca ttagtgaaca 216001 aagatgtagt aagcctgatt tcgaagagtt cgcctgtcag tcccaatgat ttcaaacatt 216061 ttaacaccaa atcttcattt atggagataa aatattcgaa tagttctact aattgtgact 216121 tgtcctctaa aatttcggaa aggtaaatca aatcagtgat tatcaaccta acttcgtatc 216181 tttctagtct tatttttttt agtaggctaa gaataatgtt caatttggac cgatcatacc 216241 ttgctatgga tcttgtatag gaagtaatga atttatcaca aactggtttg tcttccttat 216301 ctaagaaggt tagtatagac acagtgtcga acttgctatc aaataacttg aaaattttgg 216361 aaggtagctg atctacgtta ccttgtcctt ttaatgtttg gaacagctta caaatcgtga 216421 ggagtgctga atgttttgcc tctttagcat ctaagtttga aagaatggtt tccatggcag 216481 ctaagataat tgttttcttt aaaggcaaag ctgtagcaaa tacaactaat atggtatgtg 216541 cagctatttg acaatccttt gatttagagg ctaaaagttt agcagatatt tcaagtaaga 216601 ttggaacaag ctgattcagt ttttcatcgt tgtttgaatt gaaagcaaca acgttaataa 216661 agcagcatgt tgtaaataaa agctggttag tatacgttgc attatgctta atacattgat 216721 ccaaataact ggtataaagt ttcagaaaat ccatgtcatt aaagagcttt atcatggtta 216781 gcgccgttgg gggcttttca cttctaacaa aattcgacaa acaattaaac aaagggggca 216841 acttaataat gctgagaatt ctcttaaaga caggtgtttg gtagtagttg agagtggaca 216901 aaagcagcat ctctgtgttt ttaacatgta tttgaaaacg acgaaccaac cattctgttg 216961 catgtagtgt aggtgctaaa taccatttag aagaagccaa tagcaagtaa gcattgatag 217021 cattatccaa atctttaatt tcttcttttg tttggacatt tctatcaaga gaaatggaag 217081 actctgaaaa gagtgttctt gagaaaatgg caaattttgg ctcaatttgg ctcaattctt 217141 caagagcctt actagcgttt tcaaaaatga aatcgtaatc ttgtgttgca gccgtctttg 217201 agttataaat caaagaagca gaatgaagtt tttgtcttct ctttctatcc aacgcaacag 217261 tagcattgtt ggaagcaact tgagctaatt ggtcactcaa cgaagacatt ttcaaagtta 217321 ttcgtacttt ggtggccagt tagataagtc tgattctgaa aggtaataaa gaaagtattt 217381 gttacacctt cgaaaatatc tagctcatcg ctaactgaaa atttttttct ttgcttaacg 217441 cagaaagaaa aaagaaaaaa aaaaaagtca tgtgacttga atattattaa tctatgtatg 217501 ttatgattat tggctatgaa accataaaat tgaaaaaaag gattcataag ctgatatgtt 217561 atttgtactt aatgctatat ttataattta cttttgaaat ttttcttagt gggtcaaagt 217621 cttctttgat actgaagaat gacccaatgg caacacttgg tccattggtt aacaagtttc 217681 taacgaagtg gaccttgtga gagcttataa actgaaaaga ccagttttct ttttaccaaa 217741 ggggtagaca aagagtgaag aagcaaatag tcccacagaa ataccgacac aaacttgaat 217801 cattgtcata ccaaatgaca ttgaggacga tggatcggag gtgcttgtcg taatggtttc 217861 attagcatta acaattgtat ttgcactttg caacccagac aacaacgaat tttgtgaagc 217921 aataccagat ggcacttgaa cgaagattgc gggaagcata gctgataccg ctaaaccttt 217981 ccaaattctg gaatatagat tacctaaaac acctatgaca aatgcagcta aggcggcagt 218041 aaactctgtc gaattcgcaa aatgcttacc ggcccaatat gttacgacat aaccggtgca 218101 agaaatgaag accataactg gcagttgtga gatgtgtgct tgatttaata acgagatact 218161 aatggtaaac gctggaacga agaggaacct gaaccacgga gaaattaatt gaggacatga 218221 aatttcgtta gtggcattgt gatacatcca tccaaacaaa gctgagccca atgttatgcc 218281 aaaacccaaa aacaaagaat aaataatggc gtagaacata cggaccgcgc cagcaactag 218341 gcttcgactt tgcagttcta gtgcaccaca cagaataata taacctggca ggattaatgc 218401 caatgagcct tgtgtaactg caccaaagca gatgtgagaa cgagggatag agccaaaagc 218461 tctaccgcag aagctaacga caatagatgc agaaatttcg aagacgtttg aatacatgta 218521 tgacttttgt gaaagaataa attgtaatga ccccacacaa agccccataa aaaatgagat 218581 tgccaggttt acccaatcgc caccaaaggc atacggagtg accatagcgg aacaaaatgc 218641 atataaaaga acacacatcc aaggtggata tagattcgtg tcagccaaaa tttgatcgag 218701 taaagcatta ccttcatcgg cacctaaggt atcatggaca actcttttgt aaacggcatg 218761 aacttgatgc agcttccaaa ggtttagacc ttgagtacac ctaaccaatt gaacttcgga 218821 agttcttgtt gttgcatcac caaatgaaac aatcatacaa cctggaagat acaaaactga 218881 ccatctattt caaggactct agaagtcata accatatatt cttcaagcct atgcgtcgga 218941 gcaccataca tcataagagc tctacacatg cgtaggatga accggtgtct ttgtaaaatg 219001 tctgcaatgt gaaccgtaat tttcgcttca gtttttagtc ttttcttcag tctaggcatt 219061 ctgccttttt tagccttgcc ttttaaattt tgtaatctgc tacgcttggc aactggtacg 219121 tctttgtttc cagcagtaga agaaatacct tcatcatctg ttgttacagc ttgtgaatct 219181 gaaaagattg agcttgaatt ttgatcttca ttttggtaaa gtttcaataa tgaccctagt 219241 actccacttt tcacttgaga tggagggggt acgtatgtgg aggtttcaat aaacccttcg 219301 ttatcgtcgg atgaattgtt ttctgcataa tcatcaaaat gatccactgc aggagccaga 219361 aatgaatttt ttgaacttga gcctaacgtt tcgccatccg acgtacaatt tacgtcacct 219421 tctaatttga gagcctccag tttttcttta tcgtcgccct catgaacgtc tacgatttta 219481 gacgcatcag ctagatcgga taagggaatt tcttcattac ggttattttt ttctatatca 219541 ttcttcccat tttcattttc tgaaggtatt ggtgccaagc cagggaccaa acccccttga 219601 tttccagtca ggttatttat tatcttcttg atgaacgtct catcgtctcc atccttacca 219661 ttgttcctta aatgtgtgaa agaaacttta ggcttcctct tgtggcgagc aggcctatct 219721 tcttcatctt gtccatctgt gcccttagaa ttatcgctgg tttctgtaga tcttgaagac 219781 aaatcatttt ctagagcatc cgtatcagca gtgaatctta catttttgtt atcattatta 219841 gaaataccta gatcactgat gcttttacca cttaaattgc cttttttgct ctcggctgaa 219901 ttggaagtgc gatggtcact actatcttca agattcactc ccgcttgact ttgctcggag 219961 cttcccaccc gaaaatctga cacaggagtg gttggttttt catttctacc gtccattgta 220021 tagcctatcg gttattcgat cttttttctt ttgttattct atatctaaaa gataaaagtc 220081 gcacaccgct aagtaagtaa gtaagtgtta tataagattt atttagctac gttctcagat 220141 atagtaggct taaaacaaac gtaaaacata gttatatatt aatatgcaat tcggtttatt 220201 tctttttcaa gattcttccg aatttcgtca tattgggttc gcaatttttg gcgatggctt 220261 tgcttcgata tttttcggat gaaaatagtc aaaggacact agaaacacga atggcgcgct 220321 gattacggag acgtcgggct aagacaaaga gggtccattc ggcgtgctgg tggtactgtg 220381 acagataaac ccaatgcccc acttttctcg aggagttgaa acaagcggga caactgctac 220441 gtcataaaaa tgggagtacc aagggaggag ccataagccg ggtaaaattt ggcgctgttt 220501 ttcttaatct aaaaatagtt caacaataaa atttgggctc cgcccatcca gaccaaagca 220561 atcttcggcc ttaacaagcc aaagggaacg aaacccagac tctaccatgc atttcgaaca 220621 tgttgtagct aactacactg gtaacccaga tacctattct ctcagtagct gtttcaccaa 220681 gactccgcac tcatggtaag tagaaaaaga aaactctcac aaaaatctga gtggcacagc 220741 ttttccaaat acgcttttta aacttggaga aataaagatg tattacccgc tggtgcctta 220801 aaatatcctt ttctccggtt gtccaataat ttatgttacg gcggctattt gagtttttgt 220861 ggaaatctct atcattaata aatgtcagcc ttgtgtctta aatgcaattc aacagggaaa 220921 aggcgcgaga cttcggcggc aaaaagccac agacaagtgc tggttgcaaa gaggtaaaga 220981 agtaatgtgt gtaatcaaat agatatatta aggtagcaac tcaccggtct gtccattttc 221041 ttttcctgaa taacttcttc tgtcttcaca cattcatttc atttttattt tccaatatca 221101 ctcaacgaga aagaagttac aagatctatc tttcaaaata gtttacagtt acctttactt 221161 taccctttcc cttttcagtt tgttacccct tctcctaaaa gttttatttt ttgggtaaag 221221 atataaagga cactccagtc ggttaaggtg gctgtctaga gaatataaac ctgtatttat 221281 ttaccaggct tatcagaaaa gttaatcgtg ttcttaaata ttcattgaaa aggaacgtga 221341 tacagacgta ataaaagaag agtactaagc ttaacttaat aggtcattta tggttgaaaa 221401 acgtagtaga cagagttcca gtagtggctc agagttcagt gttccacctg atgtcgataa 221461 cccgccactt tctatccctt tgaagacttt atcagacaga tatcagctga tcgaaaaact 221521 aggtgcagga tcatttggtt gtgtaacttt agccaaagcg caatttcctt tatcgaacat 221581 attgggtaaa caacatgata taaggggtac tttaatggat cagcctaaaa atggtcacca 221641 aaactatata acaaagacac aaggtgtagt ggctataaag acaatgatga caaaactgca 221701 tacactccag gattatacga gggtcagaga aattaagttc atactggcaa tcccagcgaa 221761 tgaccatctg atacaaattt ttgaggtctt tattgactct gaaaattacc aattacatat 221821 cgtaatggaa tgtatggagc aaaacctata tcaaatgatg aaacatagaa ggcgccgagt 221881 tttttcgatt ccttctttga aatctattct atcgcagata ctggctgggt taaaacacat 221941 ccacgaacat aatttcttcc acagagattt aaaacctgaa aatattctta tcacaccaag 222001 tacccagtat tttgaaaagg agtacatgaa ccagattgga tatcaagata actatgtcat 222061 taaacttgca gattttggtt tggcacgcca tgttgaaaat aaaaacccgt atacggccta 222121 cgtttccaca agatggtata gatcgcctga aatattatta agaagtggtt actattccaa 222181 acctttggat atttgggcat tcgggtgcgt ggcggtggaa gttactgtat tcagagctct 222241 cttccccggt gctaacgaaa tcgatcagat atggaaaatt ttagaagttc ttggtacacc 222301 tatcaaacgt tctgattttg ttaatacaaa ccacatcaca gctccaccac ctggtggatt 222361 ttgggatgat gccagtaatt tggtccataa attaaacttg aaattgcctt atgtagaagg 222421 ttcatcgttg gatcatctac tttctagctc ccaactatcc gatttatctg aggttgtcaa 222481 aaagtgttta agatgggatc ctaatgaaag ggcaacagcc caagagcttt gtgaaatgcc 222541 attttttgaa aacaccgtgg catcccaagt agacgcaaga ggcaatgtga ctaatacaga 222601 acaagcattg atttttgcag gtataaatcc agtagcgacc aacacaaagc ccatatattt 222661 taactcttca acaaaattgc ccgcagaaac agagtctaat gatattgata tcagcaacaa 222721 cgatcacgat tctcatgcta tgtgctcacc aacattaaat caagaaaaac taactttggt 222781 agaattttta aacgaattcg ttgaagaaga taatgatgat cactcaatac ctgatgttgg 222841 aacagattct accatttcag attctattga tgagactgaa ttatcaaaag aaattcgtaa 222901 taatttggcc ctttgtcaac taccagatga agaagtctta gatcattcat tatcgaatat 222961 taggcagttg acaaatgata ttgaaattat aaataaagat gaagcagaca acatggaaca 223021 gctatttttt gacctggaaa ttcctgaaaa ggatgagttt cagagaaaac aaccatttaa 223081 tgaacatgca gatattgatg aagacatcgt tctaccatat gtgaacaact caaattacac 223141 acatacagat aggtcacatc atagaggtga taatgttttg ggtgatgcct ctttaggcga 223201 ttcgtttaat tcaatgccag attttactcc aagaaatttc ttgataccta cattaaaaaa 223261 atcacgggaa aagttcgagc ctcatctatc caattcaaac caacattttg gaaatgtaac 223321 cttctaataa tttgtcattt gactgacgaa tcgttaggca cagttatata gttatataca 223381 catagacata catatgttcg catatatatt atattactat gcattcacct aaatagctac 223441 tgctctatta atacagtgct ttttcgatgg ctttaattta acttattaga cattactttg 223501 cgtttattcc cctccaatat atttttatgt ttgtttttct tgaacatttt atgatttctt 223561 gctcttggcg gctactgatt ttgttaagca actcatcaag aggtcaaaaa aagtagaacg 223621 agatctttgt gttcggttac ccggctcaga tcctaacttg gtatgtttat tcgtataagt 223681 tactgttgtc cacaggcaat actctgcaga aaattaaaac ggcattaatg ctaggacaac 223741 cagaactgtt actactgtat gtgcgatagt tgataactgc aacattatgc ccggtatatt 223801 ctcaaaaaac cctattactg catacgaaga aatcgcaaga gaaatctttc ggtttggaaa 223861 agctcactgt gaggttcctt ggagccaata gtaatacagc acaatccaag gaaaaatctg 223921 gcctatatgc aaggaaggag agatagtcaa aagcattctt tcccctagaa gttggtgcat 223981 atatggcatc gttaaaacat attaccccca aaatttcttc tctaaacgat gtgcttggcc 224041 tttgttttgg tttttgatgt cggtcgtttg aggccccttg cggaaaatcg agatcgccga 224101 atggcacgcg agggaaggga aataaggttt aaaggcactg aaacaatagg caagaagtag 224161 gcgagagccg acatacgaga ctaatgtgtc cgcgtttcta aggccacttt tcaatgaaac 224221 ggatattgat atgctagtaa aaggacgagc tcaagagcga aaatataagt aaagaattcg 224281 agtgcacttg tctccatgca gcaagatttc atatgagtct tttttatctt tttacttttt 224341 acattacacg atatgcactt tatgaaaatt taacgaggtt ggaagccgga taatcaacca 224401 aaatcaggca cgaaggcaca ctcgtatatg catgttgttg aaactctgtt acgctgaact 224461 aacaatcaca catgtagagg tcaccgggaa aagttgcgac cccatggaag gtcgatctct 224521 tcgtttggct ttgcttggct ggcggcattg cgcttcttcg cttatacccg tctcttgacg 224581 ctcgagctcg ttcattgaga tacctttatt cttgcacatt ttctggcttt tttcgctact 224641 cgggtacatg taatcatgca cacagaaggt gctgtagggt gaaagttcct ttgtgctgtc 224701 gtttgttttt aatgccaaac tttctggtga tcaataacca cctctttttc cttcaggaaa 224761 ccttattatt gttcttggat agtactagga agtatataag gaacctcgat tttggtattg 224821 cacggctata cacatctaag aaactttgta taaaaggtgg ctaccctatt catagcttga 224881 tatcaatagg ccatctcatc actttttatt gaaaaggaaa ggagggaaat atatctgatt 224941 caaattactt gtttgcttct ctttaagaca aaagcataga taatttcagc gtggaacgcc 225001 ggaataagat tggtaccctc gtcagaaagt tacaaatacc gcttcatctt caaaatgact 225061 tcaccggaat cactatcttc tcgtcatatc aggcaaggaa ggacatacac aaccacagac 225121 aaggtcatat cgcggtcgtc gtcgtactca tctaatagtt caatgtctaa agattacggc 225181 gatcacacac ccttgtccgt cagcagtgca gcttcagaga cattaccctc acctcagtat 225241 atgccgataa ggacattcaa tacaatgcct acagctggcc caacgccttt acatttattt 225301 caaaatgaca ggggcatttt caaccatcat tcttcatcag gctcatcaaa aacggcatca 225361 acaaataaaa gaggaatagc agcagcagta gcattggcaa ctgctgccac cataccattt 225421 ccactgaaaa aacagaatca agatgataat tccaaggtct cggtaacaca caatgaatca 225481 tcgaaagaaa ataaaattac accctccatg agagcagaag ataacaaacc taaaaatggt 225541 tgcatctgcg gttcaagtga ctccaaggat gagttgttta tacagtgtaa caaatgtaaa 225601 acgtggcagc acaagttatg ttatgctttc aaaaaatcag atccaataaa aagagatttt 225661 gtttgcaaaa gatgtgacag tgatacgaaa gtgcaggtta atcaagtaaa accaatgata 225721 ttccctagaa aaatgggaga tgagcgatta tttcaatttt catccatagt gacaacttca 225781 gcatcgaaca caaatcagca tcaacagtct gtgaataaca tagaggaaca gcccaagaaa 225841 cgtcaacttc attataccgc cccaacaact gaaaatagca atagtatacg gaaaaaattg 225901 aggcaagaaa aactggtagt atcaagccac tttctgaagc cactactgaa tgaggtaagt 225961 tcttccaatg acacggaatt caaagcaata acaatatcag agtataagga caaatatgtt 226021 aagatgttta ttgataacca ttatgatgac gattgggttg tttgttctaa ctgggaaagc 226081 tcaaggtcag ctgacatcga ggtaagaaaa tcatcaaatg aaagagattt tggagtcttc 226141 gctgcagatt cttgtgttaa aggtgagcta attcaagaat atttgggcaa aattgatttt 226201 caaaaaaatt atcagacaga tccaaataat gactatcgtt tgatgggaac gacaaaacct 226261 aaagtacttt ttcatccaca ttggccttta tatatagact ctcgagaaac aggcggatta 226321 acaagataca taagacggag ttgtgagccc aatgtggaac tagtaacggt aagaccgctt 226381 gacgaaaaac caagaggaga taatgattgt agagttaaat ttgttttaag ggctataaga 226441 gatattcgta agggagaaga gataagcgta gaatggcaat gggatttgag aaatcctatt 226501 tgggagataa taaatgcatc taaagatttg gattccctac cggatcccga caagttctgg 226561 ttgatggggt caataaagac tattttaaca aattgtgatt gtgcatgtgg gtacttgggc 226621 cataattgtc caataactaa aatcaaaaac ttttctgaag aattcatgag gaatacgaag 226681 gaatccctat ctaataaatc ttactttaat acaataatgc acaactgtaa gccataaacg 226741 aaattttaaa attaatagta ttcattttaa tcttttttga aagcttaatt ttatcatcat 226801 aatttttctt ccaaaacttc aatcttggta ttttttttcg cattggtctt catttttttt 226861 cttttgtttt tagctttaat gttgaaagcg tgaatatcaa aacactttta taataaatca 226921 ccactttgta actatagaga acaattcatg ctttatttat agatgccacg attaagcatc 226981 aatcattagt tgagaggatc cttaacgtta aaatccaccg cacttttcct ttcaaaaagc 227041 tgcattgttt ccataattca tttcatggca ggttaatgac ttatttgata tgaagagtga 227101 ggttcttatc aaatgaaatt cctacatatg aattttttaa aagagagttt ttcgttttac 227161 gatatttatt tacttcatca tcgtttatca tttttcacgt agcaaatttt gaagcttcaa 227221 cttataactc atttgcatcc gattcacata tttcagctga ctataaattt ggcaacagct 227281 tcgtgacttg agcataagaa aaacatagac ttgttggata taaaatatgg ctcacagggc 227341 tttcatacag gttataatca caggaactca agtttttgga aaagcattcg ccgaggcgta 227401 tagacaagcg gcttcacaat cagtgaaaca aggtgctaca aatgcatcta gaaggggaac 227461 aggaaaaggc gaatatggtg gtattacgtt ggatgagagt tgtaaaattt taaatattga 227521 agaatccaag ggcgatttaa acatggacaa gattaataac aggtttaact atctatttga 227581 ggttaacgat aaagaaaaag gtggaagctt ctacttacag agcaaagttt atcgagcagc 227641 agaaaggtta aaatgggaac tggctcagag agaaaaaaat gcgaaggcga aagcagggga 227701 cgcttcaaca gcgaaacctc ctccgaattc aacaaattca tctggtgcag ataatagtgc 227761 aagcagcaat cagtagtcaa ggaagcctcc atcattacgt cacaagtgtt atcgaaagca 227821 tgcagcagtg catatatttt cctagttggt tgcttcctgt acgttaggaa tcttcaacca 227881 ccatccttgt atttagttaa tattagtata tgtaccaaag taaatatact cagatgccat 227941 ctcgatatac gcaccgtaca cgaaaatgaa attaaaaaaa aaatgttgga gcacaagcaa 228001 ggcagcatca gaacgtaccg tcagttggta ccaagacaag tccatccccg taggcactac 228061 aaattatggg aatgagaaag tatacaaaat ataaactgtc ttatcatgaa gaagagtcgc 228121 ttaggaattt aaactttcaa atcgcattac gcaattctct aaaaacgcga acctttccct 228181 gatatgtaat cagggaattt cctcagaata atattcgatc taagaaaccg gaaacgaaat 228241 gaaaattgtt actactttgt ttaggagtag tcaaagttca ttcagctatg ggttatgatg 228301 aaatgattta aattattctc gctccagtat taacttatta cgtaatatga gcttaaaaga 228361 gcaagctcct catcactcac actccataac atgaagaacg aaaataacct aatctttagg 228421 tttctatggt ataatgaaat taatattatc taaagatagt attaaccact actgatgtta 228481 gccttttgaa aaaaaatcaa aagaaaaatt tgaattttaa agaagaagta acaaagggaa 228541 gaagtttttg ccaatcggac aacactagct ctatttatac ttttctgttg ctccaaaaac 228601 aggaaagaac aaatttttca atttagtgtg acccggctaa taataaagag ggaagtaata 228661 ggtagggttt tactggcaag aaatccatat tgttgctccc gaataatatt ataaattctt 228721 gtaattaata caaagtttct agatccacct tgtttaaaaa tataaagtta tgcttaaaat 228781 tcttcaggga agaaggtttt caatggatga ttttacattt ttgacgaatt cctgagaaac 228841 taaattacaa tgtaaaactg tacataaata taaatattat tgttgatacg gaaagtaaaa 228901 taaaaaaaag aaacgctaaa gaatactgaa ttgccaacct aagtaaaaaa taagcgataa 228961 aatcaaagaa acggacagaa tgcatataaa aactgtaatc agtaataagc ccaaaaaata 229021 gtgatcagtc catttcaaaa attggtaaaa attgtcccat tacgagaatt gggatattaa 229081 acgagtccct ttttactgtc caacaacagg cacacttcaa ataaagaccg ttacttaata 229141 ataaattgca cttagtaaag attgcttttc catccgtagt aaaagaaaac ccttctgtaa 229201 tttttgacga ggtagaagaa catgcgttca acatcaatag ttttttcctt ttattgatat 229261 cattgtaacc aaatgccagc aattcgttaa atatttgaaa gtaattcgaa acgcttttat 229321 gatccagata ttcaaaaata aaggaggtgc ggtctaatag taaatttttg ttaaaacctg 229381 ttaaagaata gaattcgtta ctgacaaaac aaatctcgcc tgatcttctc cagatgcaca 229441 tcggtgtgca gcttactaat tttgccatgt tctccaaatc taataaagcc ctttgcaagg 229501 taacttcctg taatagcaaa tcctcttcaa tcatattgga tgttaacgaa atgaaaattg 229561 gagcatatct ttctagtata gagcgtatta taacttctaa atcatatctc aaattatgct 229621 tttgggtact gtgttcgtct tttactgagg cagatttatc aatttcagct ccttcaagaa 229681 atttttttct taaagtagtt agcagtttgg tgtatgcgag cttgtaatta tgcggtttta 229741 ttaaacattt attgtcatat aggtcttgag gagtctttac taattcacga aactttgaag 229801 gtgatatgaa atcggtatca tgtttctcca gatctgcatc ggagtgacta gaactgtcac 229861 attcgctttc cagtttggcg ttatgtgatg ggtgtgtatt agcgtttgct ccacgattca 229921 aatgcagcat gtctaaagat ataaagggcc tagacactac ttcatcatat gtattgaaag 229981 tagaagtgga atggccgatc gaggagtcct tttggtcatt cacgcttttt gtcgagttta 230041 aaaggttcgt taaatgcaat gacgaatttc cccgtgtaga tgcgctagga ttgggatatt 230101 ctgattcttg gagggaaaat atctgggagt tattcggtaa aaacggcgtt gaaatatcta 230161 ctatatcctt taatttcatg tattcgtcat tgcaccacat actatcaaag tgaatattag 230221 tttcgtcatc gacatcatcg tcactcttat tactatcgtc cattccagag tgcacaggaa 230281 cgtttgaagt agcaaccaaa caattggtag ccagcggctg ctgcattgct ttatgttgct 230341 ctaggaaatg cgactttaaa ttgagagtac tcttccgtac ggtgggtatg atggggtcat 230401 tcattaaatg tactgcttgt gaagctgata tattattaga agtattttct aagacggtct 230461 ggcggttatt cgtattgaag ttcgtaatac gtggaataga tccagcgctt tgaaagttat 230521 catttatatt atacgtatat tggatattcg tattgtgggc aggtgttttg cctggttttt 230581 cctgatctga agatagaaaa tctcgctgca gatgtacgct tgagggggat accgtcttcg 230641 acggcacatc atgtattacc agcctcttcc ccaaattcaa gtatggttgt gttccatgct 230701 tctcaattcg ttttcttgat ttccttttct tatctctgca aaacttccca atatttcttt 230761 ttaaacagtt ttgacatggc ctccctacgt cacactgtat atgtttggta tgacagaatt 230821 cacaagctgt ctggatagac tttctcgtct gtttcaactc tgaaggtagt tttttggtca 230881 tatgtatata tattcttgta tgctgtatcc aaatatatta tttctttact ccctttattg 230941 ctaagctgta atacgttaaa tcattcgaaa tatgatctat tcatgcaaaa acttgatgtg 231001 tgtaacaaag aaaatatccg gttcagagat ccgaacaaat gatagtcgta cccttcccct 231061 tagtgttaac tcgtttaagc aggctatgat gattagtaaa tcgtttcagc ctcttctcat 231121 ttcgacaatt tttgaggcct tcccttagtg agaggggaga taaccaatca gcacagagaa 231181 cgacgacggc gcggaggctg ggcggttaaa agaagataat gtgaaataga tcaacaagct 231241 ttctggtggc aaaacggcag tcagagatat acaaaagggg caagataagt gagggaggct 231301 atgtggaaat ggaatgtgcg cagatgggcg ggcgcaagag taaacattag caagaaccga 231361 ttaagtgtaa ttaacgttgg aagtagatac ttatcgaccg caagaagtcc actgtctaag 231421 gttagaaata taggaattat agcccatatc gatgcaggta aaactaccac aacagagagg 231481 atgctttatt atgcaggaat ctcaaagcat attggagacg tcgacactgg cgatacgata 231541 actgattttt tagagcagga gagatcccga ggtatcacaa ttcaaagcgc tgcgatttca 231601 ttcccatggc gaaatacttt tgcaataaat cttattgata cgccgggaca tatagatttt 231661 acttttgaag tgattagggc tttgaaagtt attgattcat gcgtggtcat tttggacgct 231721 gttgccggcg tagaggcaca gacagagaag gtttggaagc aaagtaaatc gaagcccaaa 231781 atctgcttta tcaacaaaat ggatcgtatg ggggcgagtt tcaaccatac agtcaatgac 231841 ttgataaata aatttatgag aggaacaact accaaaccgg tgttggtaaa cattccttac 231901 tatcgaaaac aaccgactag caatgattat gttttccaag gtgttattga cgtcgtaaat 231961 gggaagcgat taacctggaa tccagaaaat cctgatgaaa ttatcgtgga tgagttggat 232021 ggtacttctc ttgagcagtg taatcgttgt agggaatcga tgatagagac tttgactgaa 232081 tacgacgaag atttagtcca gcacttctta gaggaggcag aaggcgatta ctccaaggtt 232141 tccgcacagt ttttgaacgc ttcaataaga aaactgacta tgaagaatat gattgtacct 232201 gtcttatgcg gtgcgtcttt taaaaatatt ggcgtgcagc ctctattaga tgctatagtt 232261 aattatctcc cttcgcccat tgaagccgaa ctaccagaac taaatgataa aaccgttcca 232321 atgaaatatg accccaaagt tggatgttta gtaaacaaca acaaaaatct ttgcattgct 232381 cttgcattca aagtgattac ggatccaatc aggggtaaac aaatattcat tagaatttat 232441 tcaggtacac taaacagtgg caataccgtt tataattcta ctactgggga aaaatttaaa 232501 ttgggtaaat tactgatacc ccatgcggga acatcacaac ctgtaaatat tttaactgcg 232561 ggccaaatcg gattgcttac tggctctaca gtcgaaaaca acatatctac tggagataca 232621 ctaataacgc attcgtcgaa gaaggatggg ttgaaatcac ttgataaaaa aaaggagttg 232681 acgttaaaaa tcaattctat cttcattccc ccaccagttt ttggtgtttc catcgaacca 232741 aggactttaa gtaataaaaa atcgatggaa gaagctttaa acactttaat tactgaagat 232801 cccagtcttt caatttctca aaatgatgag actggccaaa cggttttaaa cggtatgggt 232861 gaattacacc ttgaaattgc caaggatcga ttggttaatg acctaaaagc agatgttgaa 232921 tttggtcagt tgatggtgtc ctacaaagaa acaattaatt cagaaacaaa tatagaaacg 232981 tatgagagtg atgatggata tagattctcc ttatctctgc taccaaattc cgatgccctt 233041 cctaactgcc ttgcatatcc attaggagtc aacgagaatt ttctgataat ggaaaaaaat 233101 ggtaattggg ataaagaatg gaaataccaa gtttctttcg aatcaattct aaattctatt 233161 attgcaagtt gcattgtggg acttcaaaga ggcggaaaaa tagctaactt tcccttatat 233221 gcatgctcca tcaaaatcaa tagcgattgg tcagtcccac ctgatattga aactccacaa 233281 gaaatcttaa aaattactag aaacttaatt tttaaagctc tcaatgactt aaaacctgaa 233341 aaatacaacc ttctggaacc catcatgaat cttgatctaa caatccctca atctgatgtt 233401 ggtacggtgt tacaagatct aacaggagca agaaaggctc aaattctgtc tattgaagac 233461 gaatcaagcg tgtcaaattc tggcgcatcc acttgtaatt ctccagagaa cagcaatagg 233521 atatatattc cctctgatgc tgttacaacc ctacacgcaa ccaaagataa aaaaaacact 233581 caagagacca gttctaatgt aaaaaaaatt ataaaagcga aagtgccact aagggaaatt 233641 accacctaca ccaataagct aaggagctta tcgcaaggga ggggtgagtt caatattgaa 233701 tattccgata tggagaaagt taccaacgat cgcctacaat caatacttca cgacttgtag 233761 caaaaatgtc cttaataaac gccttgttat atctttatca aaatggtttt tacaactatc 233821 gaatagtgtg aaccgataac tgtgtagttg tatattaata gaactttact tttgcgcagg 233881 aacaaacatt ttattgcgac ataggcatac cttgccctca gagatcttta tattcttgtt 233941 cctcgtggcc caatggtcac ggcgtctggc tacgaaccag gagattccag gttcgagtcc 234001 tggcggggaa gaatattctt tttgtcacta acacaaccat tctataaatt gaagagaaaa 234061 attaaatggc caatattcta cgtgcttgtt attagaaact cgcaacaatt gttctgcaag 234121 gcccctcatt tttttttgct atataaaata ataaatggtc acgttggcat aagtttgtgt 234181 agaaatgctt aagatcactt gcaaaaatat aaactgaata ataaaaaaaa gaggtataat 234241 actggtcgtt gctttttcaa tcaccgtgtc acccaaatcg ataatgtcaa ctttctttca 234301 caaccgaagt aaaaggagtt taacatttgc tttctattga aggcttattt ttttttacat 234361 attctgcaat ttcagctcct aaaaaggatg tcaattcacc ttttgaatcg tctaaatggg 234421 taagtctatc acacgtagaa agcaaatcat aattgatcga ctttgaaatt tttgaatcat 234481 gtttgtaatc tggatgttgt agtacaaaat ttctaaagaa ttttgctgtt gttggcaatt 234541 caccgcttgc tctatcagaa attagcttta aataatagta tagtctctcg tgtttggaag 234601 aatgctttaa ttctttccaa tctttggtta caaacccttt ttggcatagg attggcgtaa 234661 caaattgagg aaatatacca ttctctggat tatggaaaat ctcgcttata gaataatctt 234721 cagtttccac atcggtgtcg ttgcgaaatg attttttcca atgaaatttt tcaaatagga 234781 tagcatctct gtgatgggct atcttcatat tttcccatac tttggacata tgaatatatg 234841 cgttaatatt atcggaaaag gtcaaaatgc tatcgacaat caagtatatg agcacggaat 234901 acgcagcgtt ctcaaaatct aatagttgca cttcaaatgg tctgaattcc actctccaac 234961 caggagaatc ctttttgtcc ggggttgctt gttgtgtggg gggtttaaaa cgtaatgtct 235021 gccaatttgt actttggatg ttttcaaagt gatttgaaga cgttttgttg tcctgattca 235081 acagttcttc gaatgtagat actggatctc ttatgtagag atgcgcaaaa tgtttagcaa 235141 gatcatagtc cagtggcgcc ttatcattct ctagtagtcg tcctaatact ttttcattaa 235201 taggtacatt tgtgtcgtta taagtcctat tgaaaaattt cgacccaccc aagaaaagat 235261 caaccgaact atatcttgac tttggtattt caaggacttt atcttgtacg tctttggcaa 235321 tgcctccaaa tccgttcttg ttgtatttgg gtagtaatgg cgcaacacct ctttccttcg 235381 gagtacggtc gtccaccgca ccagatatca cattccaacg aacatcttgg tcggctagcc 235441 aacctttaaa agcaggcgca gcggcagaga aggctagcat tataggtgca aaattcacta 235501 atgcatcgta caggtaacgt gccttgttga tattgggtgc ctgaaaggtc acttgtaagc 235561 acgaacagcc catgccaaaa cccatggaat ccatataaat gaaacccggt ttggaagcca 235621 gtttcgcctc tttgtcttct ggtaaaaacc aatctcgatc gtagatggag tcatccgttt 235681 ctggagtagc tatatcttta tacatgggaa cattcatgca aactttttca ccacgcctgg 235741 tcctgatgga tgctgtcaag ttaggaaacc tgacatgtct gttaatgact tcatcgggta 235801 aaaacagaga cctggaagcg gcatttttat gattccacgg atccttaatg ttaataaagt 235861 cggggcatcc catcctcggg aagacagtca gcgtcaaagg gacagacctg gagcccacat 235921 gcaagttatt tttactatct tgtctcgcat attcagatag cttatattct gcaatggcac 235981 gtcttttttg catgttaacc tcaacgtaac tacccacgta attcaaatat ggagaagctg 236041 gtgttgcctc taacatatac cggccatact cagggtgaaa actcacatcg ttagcctcac 236101 aaagggacga atcctccata ttaagctcag tgagtatctt gtcatggcaa acgtcgagca 236161 tagaatttct ctccttatca tcaaaatcta caaccatgta ctcaagctcg tctccccaaa 236221 aaagagggtc attgtctctt ttaccagcag cttggaaaat atacaacaac tgctcgatac 236281 cttcatccct tatgtgttca ttgtacgtcc tagactcaaa ccactgcaaa ggcgtgccca 236341 aagctaagag tcccatttta ttcttctata tgtatatttt cgatactcta aaccacccta 236401 caatgtagcc ctatactaaa tctgctcaat tttcagcttc tacaagtgac tcgagaccac 236461 gtggaaagat ccaactactc cagcacaacg attcaatata atcgattgct ccactcataa 236521 gaggcaagaa caagcttcaa cttttggtaa gccgccgttt ataaacaggg aagatgtcct 236581 ttgtcaaggg aggcacagag catggccaat ttggcaaatt gcaggttttt ctgagtgaaa 236641 aatgaaaaag cattgtagta gagtcggctc actgaaaaac cggggaggac gaaaaggttt 236701 ccagccacag ttgtagtcac gtgcgcgcca tgctgactaa tggcagccgt cgttgggcag 236761 aagagaatta gtatggtaca ggatacgcta attgcgctcc aactaccaag gttgttgagg 236821 gaacactggg gcaataggct gtcgccattc aagagcagca acaggcatgg gaagattcgc 236881 tttttttttt tgaattacaa tagtatgtct gatgtctgca agaagtaaca ggcgtgtgca 236941 caagaatacg tgtgtgtgcg taagcgtatg cactggtggc ataacttatc taagaagtat 237001 atatcactga catagaaatg tagatataca ggtatttttc tcgataatcg ataaaaatct 237061 cgtcgcgctg aaccaaactt ggtggttacg gagagttttt ctctcatcat tactgtcttt 237121 cgcattgatt tcccctttga ccgataaaat cccttggatt cataagatta aacaaagagg 237181 tgatcaaaga gaaccctgtg aaagtttatg tttataaccg ggcataaagt gaactagaca 237241 ctttcaagaa gccaaccaaa gcatgagtaa cgaagcttac cagcatgatc ataccgtaaa 237301 tcctcaccag aagatagttg tgaacagcta cgattggtta cagttccgtg atgagcaaga 237361 tcactgtaaa agtaagaacc cgataacgca cgcttctcca ggggtcggtt cgaatgcaca 237421 gaattcagac atagcggagg cccctcaggt attccaccct tcctatcaat ctctggtcaa 237481 cgtaccgtcc gagagcccgc gacctgatca gacttcaggg tccaatcctg ccgttggact 237541 gcttcataat gcagaggaca aagcgtcagg gcaagaagaa gaaggaagtc aatatgagat 237601 tcaatattcg gtatttcgtc cgctgcatgc atatccaacc aagggcctag catatgagca 237661 gctccgaaga aaagaagaac aagaacagag ggaaaacttc aaccatttgg tttctgactg 237721 tattgaggct gtagagacat ttggacgcga actcgagaga atccaaactg gctcaagtgg 237781 gtcgtacttt gtgtatggaa cacgggccga cgaaagcgtt ccggtggggg tcttcaagcc 237841 caaggatgag gaaccatatg gcccattttc tcccaaatgg accaaatggg cacaccgcac 237901 gtttttccca tgtctgtttg gcagaagttg tctgattcca aacctcgggt acatctgtga 237961 aagtgcggct agtttgttgg ataggcgact ggaaacgcat ctagtaccct atacagatac 238021 tgcatctata gagtctttta atttttatga taatagaaaa aaatgggtat tgggatacaa 238081 ccttcagaag aagaaacaaa aaaagctggg ttctttccaa ctttttttga aggagtacat 238141 caacgccgat gagttctttc ataaataccc attacctggg atgtattcag atgttaaaca 238201 ttcatttcat cgtaagtcat ccggcgaaga tatcaatcat aaaccagaga caaccaggaa 238261 cctaacagat gagacagaac cgtccaagca aataaattcc tctccaattt cgacggaatc 238321 tgaagaaaat tcgaaatttg aatggacaga atcaagtttg agtcagttca gattggaact 238381 agaaaaacta attatccttg attatataat gagaaacaca gatagaggtc tagacaattg 238441 gatggtgaaa ctaatcaaac tttcaaacaa taagtggaga ctcaagttag ccgccatcga 238501 caatgggttg tcctttccct ggaagcatcc tgatgagtgg cgtctgtacc catatggctg 238561 gttgtatttg cctctgcaac tactagccaa accattttct gagcaaatga gatctcattt 238621 cctaccgata ttgacaagca ctaattggtg ggaagagtcg taccaagaat tcttggccct 238681 atttagcagg gaccaagatt ttaacgtccg aatgtggaag aagcaatggg cagtattaaa 238741 aggacaggcg ttcaacgttg tcgaaacatt gaaagaccca cgacaaggcc ccttggaatt 238801 ggttagaagg acaaggtgcc aggtaataga tgagaagatg caagttccct gttgcccacc 238861 tccagtttct attttcaaaa acgccataga cgaacctatt ggatcatatt ccacttcacc 238921 aatggtactc cctagcaccc caagcacaat tccatttcat gcacataacc aaagcaatag 238981 taatcctgta tactatgatt ccactctgca cccatttgct aataaaacag tgatagcaga 239041 gcggctacaa atagtcaatt ccacccccgt attcacctgg tgttgatttt ttggaaaata 239101 attcaataca tactcaatat aaagaaatca taactctact ttagcatata ggaaatagac 239161 tctttcgaaa aaacctcttt ctgtagtgtt agaaagcaac cggctattat ttttgtgtgt 239221 cttcgaaaaa tcggaaccca aacagatctt agcggattca tggtaaaaat agccttgaag 239281 aatttaggaa aataaataga tactcaaaaa ggaatagagg atcttaacaa atcattacat 239341 tacttaactc acattaaaag caaacacctt tcttaagctg ttggtgcaaa aaaggattac 239401 atctattgcc cttatgaatt tgttttggcc atcggaaacc aaaaagcaaa atgaaatacc 239461 tggtggcgat tatacacctg ggaactcacc ttcagtacaa aagggttatc aattcctcaa 239521 tcgagacata tttaaaagtt gtccacgaat tatggaaagg cagtttggtg agtgtctgca 239581 caatagaacg catttaatca aggatttaat ttcttctggc aatgttggac taggtcccat 239641 tgagattgtt cacatgtcct acttaaacaa acatgaaaaa gaagagtttg gtgaatattt 239701 ctacgttaca gggatcgaag tttccggtcc tgcaatgccc gtagagtttc ttgaagtgct 239761 aaaatcgagt aagcggattt ccaaaaatat atcgaataat atcatattga cttattgctg 239821 ttttaatttt ttcagcaatc tagacatccg tattagatac gatgctgacg atactttcca 239881 gacaacggca attgactgta acaaggaaac cactgacctg accatgacag aaaaaatgtg 239941 ggaagaaacg ttcgcaagtt ctgtcatccg agcgataata acaaatacta atccagagtt 240001 aaaacctccc ggtttagtag agtgtccatt ctacgttgga aaagatacta tctcctcttg 240061 caaaaagatc atagaattac tctgccgatt cttaccacgg tcactgaatt gcgggtggga 240121 ttctaccaag agtatgcaag ccaccattgt caataactat ttaatgtata gtttaaaaag 240181 ttttattgca atcacgccaa gcctagtgga ttttacaatc gactacctga aaggacttac 240241 caagaaagat ccaatccatg acatatacta caagacggct atgatcacaa ttctagatca 240301 catagaaaca aaggagttag acatgataac tattttaaat gagacgctcg accccctttt 240361 atctctgcta aatgatttac cgcctcgcga tgctgattca gcacgattaa tgaattgcat 240421 gagtgacttg ctgaacattc aaacaaattt tttgttaaac aggggtgatt acgaactagc 240481 attaggcgtc tctaacacat caaccgaact agccttagac tcttttgaat cttggtacaa 240541 cctagcgaga tgccacatca aaaaagagga gtatgaaaag gctctcttcg caataaattc 240601 aatgcctcgt ttgcgcaaaa atgatggaca cctggaaaca atgtacagta ggtttcttac 240661 ctccaattat tataaaaagc cattgaatgg tacccgcgaa cactacgact tgactgcaat 240721 ggaattcacg aatctctcgg gaacgttgag gaattggaaa gaggatgagt taaaacggca 240781 aatttttgga agaatcgcaa tgataaacga aaaaaaaatc ggttatacaa aggaaatctg 240841 ggatgatatt gcgataaagt tgggtccgat ttgtggtcca caatctgtga atctgattaa 240901 ttatgtctcc cctcaagagg tcaaaaacat aaaaaatatc aatttaatag caaggaatac 240961 gatcggcaaa caattgggat ggtttagtgg taaaatatat gggttattaa tggaaattgt 241021 gaacaaaatt ggttggaatg gcttattaaa catccgaaca gaagctttca tgatggaaac 241081 tgaattctat caagcttcta acaacattat cgatgaaaac ggtcatatac cgatggaatc 241141 ccgaaagaaa aggttttgtg aagggtggct agatgattta tttttagatt tatatcaaga 241201 cttgaaattg agcaagatta gcctaagcaa taaagatgaa aaacacagcg gattagagtg 241261 ggaacttttg ggtttgatca tgctgcgtac ctggcattgg gaagatgccg tagcttgtct 241321 aagaacaagc atagtagctc gattcgaccc cgtaagttgc cagcagctgc taaaaatata 241381 cctgcaacct ccaaaaaata ttcaagaggt tacattacta gacacagata ccataataag 241441 tttattaatt aagaaaatat catatgattg caggtattat aattattgcc agatatttaa 241501 tctgcaactg ctagaaaagc tatgcaacga attggggacg catatactgc gtaataagat 241561 ccttcttcaa ccttccatag gagacgaaat catggtcatg atcgatgcca tgcttgcgtg 241621 gatagccgac ctagatcaca cagtacaacc ttgaacaaaa cggtgctctt agtattatta 241681 tataaccact acggttggat ggactgaggg taagggtaac cgtatacctt ttattttttt 241741 ttttacattt tgaactggga agaaaatttt ttttgcgagg gattgacggc taacgccaaa 241801 acactccgaa gagaatgaga aaagcttggg catcgctcga agtcatcgaa cgggactatt 241861 tttgtttaaa atttcaccag atctgcttga taagggtagt ttagcttgtg tatttgggaa 241921 aggtacgcaa aagatatatt ttactaagat ctttaaatat ttttagcttg aggtaataca 241981 tgctaatttt agttgattag agattctgaa aaattcgttt tagttagtgt ttaagaatag 242041 tggcgtttat cgttttgccc atttaataat taggaaaaaa tatgtcaggg tccttttgga 242101 agtttggaca agattttggt tcacagtctc cattagctaa actgttgaac agggctttca 242161 ttaagatcga tgataagccc actagtacgg aagcagggaa aattgactct aatagcacag 242221 atgaaagttt agaaagcaat tcttttaaat cagaagacga agaagaagaa tatgagctgc 242281 ctaacagaga agaagactac aaagcttata agccaaacct gtctctactg aatgatcttt 242341 tagatgatga ggagttatat acagaactga tgtgctcgaa cttcaagcta ctagtgtact 242401 tgaagtaccc tgaagttttg tccaaattga tagattatgt cagaaatagt accatacttg 242461 agtccaatat tgatagagtt acttcagaag acagagattt agtacgtggt gaagacaagg 242521 acacaacgga ggactttgag aatgctaaag cagataagaa aaacattgat ggtacttttg 242581 aagaaaaaga acgtactcgt agtggtgaag aagaggaact ggaaaatgaa gaaaatgata 242641 gtgcatctga ggatactaga gtcactctac ctcatgaact agaggaacat gatgatacgc 242701 gaagagccag aatagcggcc gaaatattgt ccgctgacgt gtggcccata tcatctgctt 242761 tgattgaaaa cgaaggactt ctcgctaagc tttggtcgat cctcaggcta ccttctccat 242821 tgtcaattga agcgtcaaca tattttatga aaataaacga acgcctcttg gatatgaata 242881 tggacggaat aattgaattc atattaaaaa aggaacacat tgttgacgat tttttagcac 242941 atatagataa tccgcctttg atggattttt tattaaaagt aatatcgacc gataagccag 243001 aaatatcaaa tggagttata caactgttta aaaaacagaa cttggttcca aagttgattc 243061 atttactcga tcctgttttt gattcttgca cacaatctgc agccggtgat tttctgaaag 243121 ctctggttac tattagcggt aactgtccta atgagattac ttcgagcata gggcctaatg 243181 aattaacaag gcaattagtt tctccaaata tgatgaaaca acttatggat ataatgctca 243241 agggaggcaa ttcgttaaat aatggcgttg gcattatcat tgagctgata aggaaaaaca 243301 attctgatta tgataccata caaacaaatt atactaccat agaatctcat ccgccaacag 243361 atagagaccc aatttattta ggatatttgg ttaaaatgtt ttctgaacac atggccgatt 243421 tcaacaaaat actaactgag aagaagattc cccttttaca gacgtcctat ggaacgattg 243481 aaccgttggg atttgaaagg tttaagatct gtgaacttat tgctgaacta ttacactgct 243541 caaacatgac tttattgaat gaaccgagtg cctatgacat tgtaagagag cgtgatgccg 243601 aaagagagag aatcttcaat tcacaaaatt acgtagattc taacgatcgt agtgaattaa 243661 aagaaaatga agacgacaat acaggtgatg ctgatgatga agtggaagat gatacaaatc 243721 aggtagaatc cgctaatacc tccattgatg gtgaagaagt tatcgataag ttaaattctt 243781 tacagataga aaccaacaaa gtaaaccaga acatgaataa tgaagagcaa catagtttaa 243841 tgccagactt caacaatggt gattttaagg acgaggaaga tgaaaatcca tttgaacccc 243901 aatattcaga cgtcattttg gattcttctg atatagaaaa aaactttcgt gtgtctccca 243961 acgttggaga tcagctgaaa atcagtttac aagataccag agtaatagat actatgctcg 244021 aaatgttttt tcacttccag tggaacaatt tccttcataa cgtagtgtac gatgttgttc 244081 agcagatttt taacggtccc ctcaaaatag gttataatag gttcctttta gatgatctcc 244141 taatcaacat ccgtttaact gatatgatta ttaacggaaa caatgaatgc atagaatatg 244201 agaaaggaca tgacaccagg cttggatata tgggccattt gaccctaatt gcggaagaag 244261 tcaccaaatt tactgcatat attgaagaga tgaacatcac ctttgaaaat actgaagtaa 244321 tgagttcttt atttgagagt aaatggattg cctatacgga ggatgttcta gaggatctaa 244381 aggagaaata caacgccata ttaggcgata tagctgaaga aggagacatg ttgcaagatg 244441 aagaagagga tgctgtatac gacaagggag agcgcactat gggtacagtc gatgactaca 244501 ttaatgacat aatgcaaatg gacaatgtac ggtgtcaaga ggaggaagag gatgaaggag 244561 aagggtatgt cagctttgat gaagatgaac cccaagaata tcgtaatggt gattccgtta 244621 gaagcaaaga atcgaattca tcagaaggca aacgtgacca agagcagctt tactatgagt 244681 acgttaacga agatggtaca aaaacaagat taaacttcaa tcctgattct gacgccacgg 244741 aacaagttcc aggtgaagtg aatcgcgatc ataagatacc attgaagctt aagcgaagtt 244801 ttacggatgc atgcaaatct gaaacaatac caaataatac agttaatgct aaggaagaaa 244861 gtgtatttca atttagcaat gaacttagtg acggctggga gtcatcacct tctaattcta 244921 tacccaagcg tgcttctcca tcaaaaaatg gcatgaattc acctatgttt caacaccagt 244981 ttgaacttca tagccccacc gatgaatttg gaggtcataa agacgaaata ttaagcgcgg 245041 aaggccatga ctacgacata gatgaatacg atgaactgag cgatgacagt gatgaagagt 245101 atgataactg tgaagacgaa gacagtttgg attatgctga ttccgccgca tatgcattgt 245161 gtagatccaa aagtaaggac aagatatcat gggatgaaga agaacaggcg cgattaatgg 245221 gcgttgtaaa atttaattca gagcattaca gggactagga aataatacta attaaataat 245281 tctaataatt ctaatattaa taacaataat aataagaata ataattatac aataacacat 245341 gtatttccta actcacaatc gtttggacta catatgctgt ctagtgcctt attgcgactt 245401 tgcccgtttg ataacttact tcgattgttt agtattcaaa aaggaaaaag gcgttttctt 245461 tttcgtgtac tttttttcga aattctgttg aatttattcg aactcagaat tggtccatca 245521 agagcatcca aaatacaaaa taactcatca tcacacaaga agaagcacaa ctccaagcaa 245581 tttctacaat atgtcaaaaa aacttgcgtc accattgtcc ttcttacccc tttataattt 245641 gctttctgct gttggttggt cttatttgct ttacttggtc atctccttgt acccaaaagt 245701 tggacagcca gcattcttct accaaactaa aaatgtcgct acccttgttc aatgtggtgc 245761 tataatcgag atcataaact catttttagg agttgtacgt tccccattgc tgaccactgt 245821 tgcacaagtg tcttcaagac tactagttgt cctcggcatc ttccaattgt tgccaaacac 245881 aagtggtgtt caatcagttg tttacatatc attattactg gcatggtcta taactgagat 245941 cgtcagatac ttgtattatt ttttcatgtt ggtattcaag aatggcgcac caaagatctt 246001 aattctatta agatataatt tgttctggat tttgtacccc actggtgttg ccagcgaact 246061 acgcattatt tactgtgctt taaatgcagc tgaatctcag tattctttac tttacaaaag 246121 aattttaata gcggccatgc tcgcttatat cccaggcttc ccaatgctct tcctacacat 246181 ggtagcacag agaaagaaag tcatgaaaag tttaagatcc tctttcggga agaaactaat 246241 ttgaattctt tagataaatt cttctgtatt ttttataaga atattagcct tcacattgaa 246301 atggcttcaa cgctcttaac cataatcact agtatcttgc ggtgcacggg ctttatattg 246361 agcaaaattg cgaagggtag ccgaattaga gaactcttag aaagatgtcg aagctcactc 246421 ggagtcgacc ttcacagcct actgaaacaa ctgtgccgag acaatcttaa gtgtgttgct 246481 ctaattttca tgctacaact gaaattcata tggccagtgg ccagaatcac acctatttat 246541 aggccattta ccagtcatcc attcagaaat ttagctactt cctcaagcat cagtagtaca 246601 aaagctaaga ctactaagac agatacaact ccactaaaat tatcaaatga actatatgca 246661 atattcaaga ttcataatcg tccatatttg gtgaccgagg gcgacagagt tattcttcca 246721 ttcaaattga agcaagcgga ggtgggtgac attttaaaca tgaccgatgt aacaacttta 246781 ggatctagaa actacaagct agttggtcat ccaatcaata cttctctgta tactttaaaa 246841 gcaaccgttg ttgggaaaac taaaagggct ttccaaacta gggaggtaac gaagagaaga 246901 aatagacggg tccgtcatgc aaagagtaaa ggtgatttga caatcttaag aatatcagaa 246961 ctgagtatga actgaatttt agggatatgt acatatacgc atacgtataa aatcatgtaa 247021 ataacaataa aatttgacac actttcttcg gccccaatgg ccattcaatt ccagaccgac 247081 gcgtcttcta agttataatg ctatgaaatt tcaacaagtt aattaaaagt aagcataata 247141 ataaaatcag gtaatggatt caccaaaaaa aaaaataaaa aaacaagggc agaggggtga 247201 ccattagtac gaaacactaa atatagtatt aaaatagttc aactccacct ccaaatgccc 247261 tttttgagga aaatagcggg gacagcacat acacattcta ggtctgattc gaactcatct 247321 gtgaaattcg gccatcagcc gactagttcg gtagcatcaa ccaaaagttc aagcaaaagc 247381 cctcgtgcaa catctcgcaa aagcatttat gatgatatta gaagccaatt tcccaaccta 247441 acccccaact ctacctcttc tcagttttac gaaagcacgc cagttatcga acaatccttt 247501 aattggacga cagatgacca catctcagct ggaacgcttg aaaacccaac gagctttaca 247561 aacagttctt ataaaaatga caatggacct agtagcctct ctgattcgag gaaatcctcc 247621 ggtggcaata gcgtaaatag tttgtccttt gacaagctaa ttctatcgtg ggatcctaca 247681 gaccctgatg aatggacaat gcatcgcgtc acctcatggt ttaaatttca tgattttcca 247741 gaatcctgga tattgttttt caaaaagcat caattgtttg gtcacagatt tataaagttg 247801 cttgcatatg ataatttcgc tgtttatgaa aagtatttgc cgcagactaa aactgcttca 247861 tataccaggt ttcagcagtt attgaaaaaa acaatgacca agaacgtaac aaatagccat 247921 attcgtcaga agagcgctag caaacttaaa agttccaggt cttccagcga atcgatcaaa 247981 tcaaaattaa aaaatagtaa atcgcaagag gatatttcaa attctagatc aacgtcagaa 248041 tctgcattga gcccaacaaa atcgggccct tccaagaccg atgaaaagaa ttttttacat 248101 tctacttcaa cacaccaaaa aaccaaaagc gcaagttcac tatacagaag aagttttata 248161 tccctaagag gctcatcatc gagcaatgct tcctcagcaa aatcaccttc aaacatcaag 248221 ttaagtatac cggctcggcc gcactcaatt attgaatcta acagtacact taccaaatcg 248281 gcgagcccac ctgcatctcc ttcgtatcct agcatattta gaagacatca caaaagtagt 248341 tcatctgagt cgtcattatt aaattccctt tttggtagtg gaataggcga ggaagctcca 248401 acaaagccta atccacaagg tcatagtctg tctagtgaaa atttagctaa aggaaaatct 248461 aaacactatg aaactaatgt gtcttcacct ttaaaacaat cttcactacc cacttcggat 248521 gataaaggta atttatggaa taaattcaaa agaaagagcc aaataggggt tcctagccca 248581 aatacggtag cttatgtaac gtctcaagaa actccatcct taaaatcgaa ttcgagtact 248641 gctaccttaa ccgtacaaac ggcagatgta aatataccat ctccatcttc atcaccaccg 248701 ccaataccca aaactgcaaa cagaagtttg gaggtcatca gcacagaaga tacacctaaa 248761 atttcttcaa ccacggcgtc ttttaaagaa acgtatcctg attgtattaa tccagacaag 248821 acagttccag tgccggtaaa taatcaaaag tatagtgtaa agaacttttt actggaccaa 248881 aaattttatc ctctgaagaa aacagggtta aatgatagtg agaataaata tattctggtt 248941 accaaagata atgttagttt tgttccgcta aacttaaaaa gtgtagcaaa attatccagt 249001 ttcaaagaat ctgctctcac aaaattggga atcaatcaca aaaatgtcac tttccatatg 249061 acagactttg attgcgatat tggtgctgca attccagatg atactttgga atttttgaaa 249121 aaaagcttgt ttttgaacac ttctggaaaa atttatatca aagaccaaat gaagcttcaa 249181 caaaaaccga aacctgctcc tctcacctca gaaaacaatg ttcctttaaa atcggtgaaa 249241 agtaagagtt caatgaggtc cggaacaagc agtctgatag catcgacaga tgatgtttcc 249301 attgtcactt cgtcttctga cataacatca tttgatgaac atgcatcagg aagtgggcgc 249361 aggtaccccc aaaccccgag ttattactat gacagagttt ccaatactaa tccaactgaa 249421 gaattgaatt attggaatat taaagaagtt ctttctcatg aggaaaatgc accaaaaatg 249481 gtttttaaaa caagtccaaa attagaactc aacctaccag ataaaggaag taaattaaat 249541 attcctaccc ccataacaga aaatgaaagc aagagtagtt ttcaagtgct aagaaaagat 249601 gaggggactg aaattgattt caatcatcgt agggaatcgc cttatacaaa accagaactg 249661 gcaccaaaaa gagaagctcc caagcctccc gcaaatactt ctcctcagag gaccttatca 249721 acttctaaac agaataaacc gatccgccta gtgagggcaa gtacaaaaat ttcgagaagc 249781 aaaagatcga aaccattgcc gccacaatta ttatcatctc ctatagaagc tagcagctcg 249841 tctcctgatt cgcttacttc ctcatatact cctgcttcga ctcatgtttt gataccgcaa 249901 ccttataagg gtgcaaacga tgttatgcgt aggttgaaaa cagaccagga ctcgacgagt 249961 acttccccat ctttgaaaat gaaacagaaa gtgaatcgct caaattcaac tgtatcgact 250021 tcaaattcaa ttttctattc tccttcacca ttgttaaaaa gaggtaactc aaaaagagtt 250081 gtttcgtcga catctgcggc cgatatattt gaagagaatg acataacatt cgcggatgct 250141 ccgccgatgt ttgacagcga tgatagtgat gacgattcta gttcatccga tgacattatc 250201 tggtccaaga aaaaaacagc tcctgagact aataatgaaa acaaaaagga tgagaaaagc 250261 gataacagtt ctacgcattc tgacgaaata ttctatgatt ctcaaacgca ggacaaaatg 250321 gagagaaaga tgacctttag accatctccg gaggtcgttt atcaaaattt agagaaattc 250381 ttcccaaggg ctaacttaga taagccaatc actgaaggaa tagcttcacc aacatctccg 250441 aaatccttag acagcctact ttcaccaaag aatgtggctt catcgagaac tgagccaagc 250501 actccttccc gtcccgtccc tcctgatagc tcatacgagt tcatacagga tggacttaac 250561 ggtaaaaata aaccattgaa tcaagctaag acacctaaaa gaacaaaaac cataagaacc 250621 attgcacatg aagctagttt agcaagaaaa aactctgtaa aactaaaaag acagaacacc 250681 aaaatgtggg gtacaagaat ggtcgaagtg accgaaaacc atatggtgtc aattaataaa 250741 gccaaaaatt cgaaaggtga gtataaggaa ttcgcctgga tgaagggtga aatgataggg 250801 aagggatctt tcggtgctgt ttatttatgt ttaaacgtta ctacaggtga gatgatggcc 250861 gttaagcagg ttgaggtccc caagtatagc tcacaaaatg aagccattct aagtaccgtg 250921 gaagcattaa gatctgaagt gtccacgtta aaagatttag atcatcttaa tattgttcaa 250981 tacttaggtt ttgagaataa aaacaatatt tacagtttgt ttttagaata tgttgctggt 251041 ggctccgtgg gatccttgat tagaatgtat ggaagattcg atgaaccgtt gatcaaacat 251101 ttaacaacac aagtattaaa aggattggca tacctacact cgaaaggtat tctccacagg 251161 gatatgaagg cagacaactt acttttggat caagatggta tctgcaaaat cagtgacttc 251221 ggaatttcaa gaaaatcaaa ggacatatac tctaattcgg atatgaccat gcgaggaaca 251281 gtcttctgga tggctcctga aatggttgat acaaagcaag gctacagtgc aaaagttgat 251341 atatggtctc tgggatgcat cgttctggaa atgtttgctg gtaagcgccc gtggtccaac 251401 ttagaagtcg tcgcagccat gttcaaaatt ggaaagtcaa aatcggcacc accaattcct 251461 gaggacactt taccattgat atcgcaaatc ggacgaaatt ttctggacgc atgcttcgag 251521 ataaatccag agaaaaggcc aaccgctaac gagcttcttt ctcatccttt tagtgaagta 251581 aatgaaacat tcaatttcaa atctaccaga ctcgcgaagt ttataaagtc aaatgataag 251641 ttaaactctt caaaattaag gataacctct caggagaata aaactgaata gctattagga 251701 tcgatctata cttaagatat ttatgcatac gtaataatat agaacaataa acatagatga 251761 cggaatgacg gaatgactga aaattaagaa caaagaaaat taaaaaattt ctgctgatac 251821 ttattcagac gaaaaatggt gcacaataag ggtgtcaaaa cgacgattcg acccttcaaa 251881 tattacagtc ctcacctctt cgctgaaggg ctcactttca tcaggaaggt cctctccaat 251941 aataaaggta gtctcctcta tatcagctaa agcagtatct gataaaccaa catcaagcac 252001 agtctctata aaggacggct tttcaattgc ttcttctgga actttcgttt caaaggggat 252061 atccacaatt ttaatggtag attcgtttag ccagtcatgc tcagcaaatg cagttgacaa 252121 atcttttgcg aaatcaatat tcttgctgtt aataaatata ctacaggatg cattatcatt 252181 attatagcca tctctatagc atatcaataa gagaagatat agtccaagat aatcggattg 252241 tgtcaggtat ggttttggaa gtaataaatt gaaccgtttc ctcttaaagc gatcagcatt 252301 taatctgcca taggtatttg aaatttgaac ggcaaaattt gccttgagtg actggaaaat 252361 agacttgaag aaagtagatg atagttcatt cagacctagg agatgagaat aaatgtgatc 252421 aaagtttgcg tatttttcat caatgaagac tgggctccct ctatactcat acgaggcccc 252481 ttttaatggc aataagatca gatctgtgga atccattttc atcgtcgcta tattagctgc 252541 cttttcacgc attgtagaaa atatgacttc acttgaaaat ggtattttgc tcaggtttga 252601 aaatatatca aaaatttgta atagtgaatc tgtatttgcg gtaaagtggg gatcatcatt 252661 atatagagaa gatgattgca gcagatcagt tgtccgttca gtgagcaatc gtaaatgaat 252721 ggccctcaat gcaccgactc cctcaaacgg ggtcaatttt tcatctataa cacttaaatt 252781 ggtatccaca tcgtcaacgc ttttagacca gatatgaacc atctttttta ttttgaatgt 252841 gttagatttc aatgtggaat cagtagctgt tgtcattctg ctcaaggagg tttcgttctt 252901 atgtttatta ttcttaggct tgggagatac ccctaaagac aggtaattta gcagctttag 252961 agatggagag atcgcttctg tagtgtttat caccgtggtc agttcaccaa ttctatattt 253021 gctaacatct gccaatgaat taagttgagt gttaatttca gtcttgtcca caccctcaga 253081 atcgagacca tctgctgcac catcatcttc tgcaggtgta gataaggatt tgcgaacacc 253141 atcccggtat gaatctgggt aaacaagctg agtcagagga gtagtgacaa aagtagaaac 253201 taatgccatc aacacaaaca taccaaatat ttttctactg ataatgcccg cattcaaacc 253261 aacagttaag acaacgattt caacgatacc tttgcatgac atcaaaacac cggctgcagt 253321 ggcttctctc caaaataagc cagtaagttt agctgtaaga gtacctgaaa taattttggt 253381 gaaaatggcg atgccgattg tggcgaaaac atagccccaa tctcttccct catttaatag 253441 agtcaaatcg acatttaatc ctgcaacagc aaagtagatt ggaatgaaaa caatgttagg 253501 aatatcttcc atcctttctg ttaatttaac aacgtagtga tcatctctag gaactactaa 253561 gccagcaatg aaggcgccaa aaataggatg aactccaata atatccgtaa aataagcaga 253621 aatgaacatg atgaatagaa tgcacatcgt tgccaacggt gaaggcttgc ttctgtccaa 253681 ttcatgggtc cttatgagca cccatcttaa taggtatttt aagggaaaga aataaatcaa 253741 aaaccatgca aacgtgataa gcagaatata aacggtattg acagggctcc cttctgcact 253801 agaaagaata atacttaatg ctaacaaaat ccatcccatt atatcgttaa tgatacccgc 253861 cgcaaggaca acgatacctg ctctatcctt gatcaagcgc aattcattta aaatacgaca 253921 taaaactgga aaagccgtaa cggagatgga aacagctata aataccatga agacagagaa 253981 tttaatatgc ctttcgcctt ctgttttgtt tgcataagtg tgaaataaag gaatcgccag 254041 cagacaacca aaaccgaatg gcactgctaa agtgactata cctatcacga gtgctttctt 254101 taggtgtttc ttgatgaaag caatatccac ttctaaacct aaaaaaaaca taaacagtat 254161 tattcccaaa ttcgccacta aatttagccc cgggatcgat gatgtaggga aaattgtgtt 254221 tgtatagttt ggaatttgac caaatatagt aggccccaaa ataacaccag atataacttc 254281 tgaaatgact ttaggctgcc tcatcattga aaagggaatg tgaattaaat tgcataccag 254341 tagtatgaga catgcttgaa agagaaataa tgtaagcggc gaactggagt tgtagtggaa 254401 cggatttaca cccgacagaa ttcctcctac agtgtttgcc atttgataga atataaataa 254461 tacaacttcg taataataat aatcgttggt atcatttgat gtgtgcttta gcaacaagag 254521 atgatataat aagcgaacag tttttgtttt ttattttccc ttactggagc tcagccacat 254581 taatgcgaga cgcaacgggt gcataatatt gaaagcgcat ttacagcaga aaaatgcttt 254641 cagtatttat tttgagatgc tgaatataaa tatttagaga atacatccgt agtagtctac 254701 agtaagatat aaatcaatgc ttcgggtgtt tgtatatcaa agtgtctttc tatgctcacc 254761 caaaaatttt cttttgctta taactttata aagctcttcg tcttctacta gattaccaac 254821 taattcttct atgttcttga aaagcatcat aaaagcaaaa tgaggttcat ttaacgggaa 254881 cttgaggggc gtatcaggtg atatccaaaa ttcgggtccg cgtgtgtact cctcaatatc 254941 tgtaatgttc ctcaaatgta gtttatgaat gtacgaccag tcggaaaaac taagtgtgta 255001 atctttatcc gccagacata tccgatgtag ttttttgacg gctttaagta gctcttgcaa 255061 gttccttaaa ttacaggtcc ccgagtcctg tagtgcatat tcagcagaag aaacatattc 255121 tagaggaagt attccctctg ggctagatgc ttttgataat gaagaaaatg attcttgcag 255181 gcttgcagga ggggatgtca ctccagaatc attctcttct gaattattat cgttgaattc 255241 agaaatttga ctggattgtg agctcgttgt attttcttcc agatcaccat cagctgtgtc 255301 agattcttcg aaaatttctc cagtgttcac cataaaggaa agtgctcttt gacgcccatt 255361 aaaaacgatg gacttgactt tattattgaa tgattcaccg atcttaatat ccagagaagt 255421 ggaaatgtca aacaacagat caccgactgt agataggata gcccccatta atggcacggc 255481 tcccaacgcc caaatcacaa aaaaagcacg gcctgcacca gtccttggag catagtctcc 255541 gtatccaatg gttaataagc acaagaaaca aaagtaaata caattgaagt acgaccaatt 255601 ttctgcgaat ttgaatacaa gagctcccaa taaccaaaaa gccatgaaaa ttgcaatagt 255661 caccgacaaa gaaaaccaat gctgcttcct tgaggccgtt tgtcggatac acttcattaa 255721 gtcgaacgct tccctttcag ataaattttt actactatcc atataatgtt tccacgattt 255781 ggacctgcct ttttcaactc tgtggaaaaa gaaaattggg ccagaggact tttgaatgat 255841 ggatcttgtc ataaacacta ttaaacccat caagacaaca ccagatagcg aaaagattaa 255901 aaccatgatt ttggcgccaa ccgacttggg caggatgtca cctagtccca cggttaataa 255961 tgataccgtg cagaaatata atgcatttcc gtaagtgatg tgcaataaac cgctaaacat 256021 acccgcaccc caaatcaacc ataaagacaa tagtacagtg tatgccatga tacttctttc 256081 attgggcaaa aggttgaacg ttggaggata ttttcctaat ttatatccaa taaaatgtat 256141 tgttaaaata atggtgcata ccaaatatag accagaactg atacaggcaa accaaaatcc 256201 gatagtctta ctgtagatgc tgggcatgtc attcaaggag catacaatca cgtccaccaa 256261 aagcatccct ccagctattg tccatcctgt tatatttatt aactgagatt taagatacgt 256321 caacttctta ctgaaatgta gcattagtat aatatttgac gtaaaaccca gtaccaaaga 256381 gatgatatta acggcaaaaa taccaggagg atcaaaaact gtctttactt gattcatcaa 256441 aacatcggtg tcattgcttc gtggatttgt caccacggag ttgttcttta aggatctcca 256501 tttttcaact acacaggcta tcgagatagt gttagctacg ggacccaagc aggcagtaat 256561 cacagggaaa tagcatgaaa ccacaaacca aaagacgaac agtgttgaag aaggctctgc 256621 attaataata ctaactcttt cgtcccggaa ccgcaatgca tcctttagtt cctctgcaag 256681 aacaccctta gcttgcttcg gtgtgttgtt tgaatgagaa tcaacagcct gagctgagct 256741 ctcttgctcc actgtcgcca tattgccata tcccagcgtt tgtttggcaa agctgttcat 256801 gaaccttgtc atatatatag aaatcggtaa aataaataca agaaatatgc tttgttatac 256861 tgctagaaag gagtgaagac atctgctcac gatctacgag atgcggctat ttttgatgga 256921 aaaagataca tagggtcagg catttttgcc atattgaata accaagatgg tactgagtac 256981 tcaggtaatg tatattacat tgagtacttc acttgtatac acaaccactg cttcgtattg 257041 tatatcaagt atctaactgt tgataaacta caactttctc ttcaaccata atgatagcgc 257101 cgcttaaaac atgctagggt aacgagacgc gaatgcgaaa aactcccaaa aaaaccaaaa 257161 caaacaaaag tgacaacaat tagaacgatg ctgaagaaga ataggagcga gtttagagtt 257221 acctccagct atcctgatac tactgcttag gctaccttcg cagagtctcg ataaatttgc 257281 agtcggcaag ataagaatat ttctctacag cttttagaca gcttcctgtc cctctagttt 257341 cttttgccat ccataattgt actctgcact ttgagtatca ttccaatttg atctttcttc 257401 taccggtact tagggatagc aaatgtcgtc gaacaatgat ctttggttgc atttagtatc 257461 ccagttaaat actcaacaga gagcagcggc cctctttgat tacactagag ggctgcaggt 257521 cattgccggt cccggcacag ggaagactaa ggttttaact tcaagagtag cgtatcttat 257581 tctgcaccac catattcatc cccgcgatat tatagtgact actttcacta acaaagctgc 257641 taacgaaatg aaagagcgtt tgcaagaaat gttacgcggg gcaggcgtga atatttcgga 257701 gctcttaatt ggtacttttc atagtatttg cctgaaaata ctttatagat ttggccactt 257761 ggtggatcta cagaaagact ggagaattat tgatgagaag gaaatagatg tcattttaga 257821 tgatatgatc gaaaaagttc ccgaccaaat aagggattat gcttcctcaa tcacaaggaa 257881 agtaaatctt tgtatgccga gtaaaaatgg agatgaatgg actattcatc cgaagctgat 257941 caagaaacag atatcaaagc taaaatcaaa cgcaatatta cctgaggaat acatcttaga 258001 ttcgaatcat gacgccgcgc ttggttactt ttaccaaata taccaatcag agctaagcaa 258061 gaaaaatacg ttagattttg atgacttatt aatgtacacc tttcgtttgc tgactagagt 258121 gcgtgtttta tccaacataa agcatgtttt agttgacgaa tttcaagata ctaacggcat 258181 tcaattggac ttgatgtttc tttttgctaa gggaaatcat catctttcga gggggatgac 258241 catcgtaggt gatcctgatc aaagcatata tgctttcaga aacgccttag cgcacaactt 258301 tctagaaatg ggcagaaaat gtcccatcga gtactcaact atcatacttg ttgaaaatta 258361 tcgttcatca caaaaaattc taaatacaag cgaaatttta ataacgcaac aaaacaaagg 258421 tcggcagaat agggctccac tccgtgccca atttgacctg gattttccac cagtttacat 258481 gaatttcccc gcttactttt tggaagcacc ttctttagtt cgggaactac tatatttgaa 258541 ggcattgcca aacctattca catttaatga ctttgctatc ctagtaagac aacgaagaca 258601 aattaaaagg atcgaaagtg cattaataga acatcggata ccctataaaa ttattagggg 258661 ccacagtttc tgggattcca aggaaacaag agcgatgtta aatttattaa aattgatatt 258721 ttctccgaat gacaaacatg caattcttgc ttcactttta tatccagcaa ggggccttgg 258781 tcctgctacc ggtgagaaga ttaagaacgc attggacacg ttagctaccg atgtgtcatg 258841 tttccaaata ttgaaagaca taagtagtaa aaaaataatg ctagacatac cgacgaaagg 258901 ccgttctgtg attgctgact tcatttcaat gatagaaaat tgtcaattgt tgctccagag 258961 cactttacta gggggtcttt cagatttatt tgataagcta tatgaattat caggtctgaa 259021 atacgaatac ttgtacaagg atggtaagaa aaaaaatgat cagcttgaaa aatccgaacc 259081 taatttatta aacgcaagac ataagaatat tgaacttttg aaaaactatt tcctggctct 259141 tctttccaag tcagaatctt cagataaaga aaaaaatgaa gccattaaag cagcaacaga 259201 tgaagccgaa ccaatagaga acaaggtcat cactccaaaa gaatacctcc gtaatttctt 259261 caattcactt tcccttcatt ctgatgcagc tgaggaggaa gagtcggaat ccaataaaga 259321 tgcaaaaata aaacgtgaga agaatgggtt tgtcacgata tctacaattc acggtgccaa 259381 aggtcttgag tggccggtag tttttattcc tggatgcgaa gaaggtataa ttccttgtgt 259441 gttcaacgat gataagaaag acgaatcaga ggaggacgaa gaagaagatc aagaaaatag 259501 taagaaagat gcaagcccaa aaaagactag agttttatcc gtggaagatt ctatagatga 259561 ggaaagaaga atgttttttg ttgcacagac tcgtgcaaaa tacctgttgt acctatcaaa 259621 tactgtaact gtggaagatg tcgatagacc aagaattgca agccgatttt tgactactga 259681 cttgataaaa gccatgtccg atagccaaaa attatttgaa agtacgaata gtatcaaaaa 259741 actataccga attttgaaca aaaagccgcc tgctgaagat gataaactat tctcccttga 259801 ccaattgcgc aaagactata accaattcat tgaaaatagg agagaaagga tgatttggca 259861 agggatacaa atgaatgatg tctatggaat acagttgtct agaaataaat tattgggttc 259921 tgttagtgat ttcacgtcag ctgcggacca gttacgactc gaaacgcaaa actctatatt 259981 cccacagaag aaacttattg aaaaatcacg cccatccaaa atcaatggca attacgctcc 260041 taaaagtaga gttaaaagtc cagaaaaaag gtacgctcca gaaactacat cattccattc 260101 tcctacaaag aaaaaggtgt atgcacctca atacgtttca acaactaatg tacctagtag 260161 gcaggagttt cattcttcta ctgggaaaaa tattcctttt ctgagaagag aagataggtc 260221 catcacagac atatcaccac gatcatcaac gaggtcgtta aaaggagcat ctccaaataa 260281 gacgagccac atgtcagatg atttaatgag accatcacct acgaggaagg acaaagttac 260341 tcgtaatatt catttcgcaa ctgcaggaac tttcagaata gaaacccagt caaatgttga 260401 tgaactgcat cctccggaat actccaataa atcagggcag tcgcttacgt cgagtgaatt 260461 ttctgggttt tctagcgcgt gcagtaattc tgatcagcca acgaacttaa tagaagatat 260521 aaacaacgaa ttagatctat ccgatgagga gttattaaat gacatatcaa tagaaaggag 260581 gagagagctt ttgggctcga aaaagacgaa aaaaataaaa ccaaaaactc gaaatagaaa 260641 gtctaagaga ggtgacaagg ttaaggtgga ggaagtgata gatttgaaga gtgaatttga 260701 ggaagatgac agcagaaata caacagctgc tgagttatta cataatccgg atgacactac 260761 agttgacaat cgtccaataa tctccaatgc taagtttttg gctgacgcag caatgaaaaa 260821 gacacagaaa ttttccaaaa aggtgaagaa tgaacctgca tcaagtcaaa tggatatatt 260881 ttctcagctg tcacgtgcga aaaaaaagtc aaaattaaac aacggtgaaa tcatagtcat 260941 cgattagtag cactttcatg cctgactacg tcaactattg gaggcggttt ataattttta 261001 tttaaagcac ataggagtta attttatttt actggtaggg tttgtatacg aactacatgg 261061 aaatgtggat ggtgtgttat tatagcttaa tgaatattct ttttctatac aagaaaaccg 261121 atatgacagc tatgaatgag cagtatgcca acaaaaccag gaatgatttt aagggtgaag 261181 aatctatcgt gaccatagac atattgacta aaccagtaga gacatttgcc aacaaaaata 261241 aaaacaaccc attggagttg attgattcca agcattcggc aactttataa tattccgaag 261301 aattaccgaa aattttgtca gtcaagcagt acccagtcaa aaatagtaaa ttataagtaa 261361 tgacccacaa agtatatggt aagttagcaa accttcttga aacactataa ggatggtatt 261421 gaaaaaccaa ctggctgata acaagaaaaa ttgtactcca tatacagagg ccacttaatg 261481 gggttactga agtccaatag tcccaagtcg aagacttctt tgatgctgca actacgtctt 261541 gcgtagaagg cttataaaga ttgtttaaag ttggtttatt tcccaacaag taaaatcccg 261601 tgttttggcc ccaaagaaaa atcgagcaat aacctagaaa tgagaagatg ccttctctat 261661 tagcactgaa gaaacaattt ctatcagcca aaattaaaaa gtttaaagtg cgatcgtcct 261721 ttaaaagtag ccattcataa atgcatgaaa tgaatattgc aattgagcag cgtggaacca 261781 ttcttgtgac gggatcaata aaggtcaata caagtggcaa caatgatagg gtgataaaaa 261841 aattccaatg aaccccatat tctgtgacat gttcttgata ttccaaattt tttacaaaaa 261901 acaacctcag caatcctagg aacaatagag ttcctcctga ttttaaggca ttaaatgcat 261961 tttttaagaa gctgggttta ctcttcaagc ttaggttttt caacagtgcc ctagaagaaa 262021 caataccgtt actgaaaacg aatgatccta caccaagatc catcagggat gtcccccaag 262081 tttccacctt ggcaaacctc cttgggaaaa ttggaaaatc tacagccaag atggcaatag 262141 cagtcagaat aagcatccca ccacgatacg cagtaatata cggctttttt tctagttgga 262201 accgctgtgt aatcattttt tttttattgt atattggatt agaaggttta ctcgagctag 262261 taaattttcc atatatgaat gcgagcaaac aaggtaacag tattagcgtg tttagaaggt 262321 atggttcact agcataaata gtaatagata gaagcaaagc aacccagttc aatgcaaaat 262381 caattatgta ttgcacgctg gaaatgccag gaggcataag gttggaattt ttcaataagt 262441 tccatgatat gtaagttacc aaagcaattg atgtcactgc gttaatttct gttatagaac 262501 cgccattgag ccctgtcaca aagtcctctt ttctctgttt taaagtcgac atattcttct 262561 gatgtactgt tgccatttat ttagatattt acgtgtcttc ttattgcgat cctctttttc 262621 tcatgctgtt ttttcacgcg agcatgtcat ggaaagtatt atcatacaaa acggtaatac 262681 atatagatga gtagatttga ataatgctgt agatggcgta tgtaaatgaa tatcttataa 262741 aattacggac tacatttcaa gaatctaatt cctttgtctg atttcttgtc tgtcgtctca 262801 taggtttttc taaagaggca gtacgtttct tatcttgaat ggagccatag gtaacttgag 262861 tatgtgaaac ttcctcagtt cttgggatct cttctggatt agaaattgca gtcggctgct 262921 ctgtaggcac attttctgac attattgtgc cccaactcgt ggttcgttta atttgtttag 262981 gaacgaaatt ttttggcagt gactccaact tgatcctttt cgtatccggc atttgtctct 263041 ctgaagaaac atccatgata ctcgatgaga cactacgctt ttttcttcca gaatcagttt 263101 ctctaatttt ctgcaataat tcgtttttgg tatctttcat agagtgctcc gataatgagg 263161 aattgtttct tttcaaaaga atagttttgt cgatttttgg atcattgttt tggtactttt 263221 tttctgaact aatgctggta tagtatggtt tttttatctt acatttaaaa tcgtccttgt 263281 gtcctcttgg gcagataata caccacttga tattgtttaa aaagatttca ttattttctc 263341 cagatgcagc ggacaataat ttaaaaataa atgctggagt aactaccggt atggagtgga 263401 atttcttgat atattcaatt ttccttttca tcgaatttct caagattgaa ttattttgaa 263461 aatcttttct gttattatca ccaggatcat cattattgtt attaatgcaa aactgagtaa 263521 aaagatcgct aaattcattc gaccataacg gatgggtttt cgggatactg ggtaaagctg 263581 ctaagttgat tagcagaatg tcagtggatt tattgaggta ttctacataa ttgatgccca 263641 ttggttttag aagatttaat actttagtca gatgtaacag ctctacgcca gagaatccag 263701 tgatagtaac attcagaaaa ggggaagaag aaaattcatg atgcaataac tttgaagaag 263761 acgaaacttg aaactctatt gtgctgagga agggttttga ccataaatct attgggtgta 263821 gtaatttttg ataatacaag cagcgttcaa tgaaaaattc tgtaactata ccatcattat 263881 catctataat ctcaggtaaa tcattgaagg agtcaagagc tttattactt ggaatgatgt 263941 aataagaatg atcgtaaatg ccgctcaagt aagacgtctc aattttaccc ccattttgaa 264001 caacaatttt ggttagtatt gaacggtgat tgccaggaaa aatatgatga atgataaacg 264061 cacaattttt gaaaatcaaa gtactattat cacttaaatc ttcttgtttg ttatttatcg 264121 ataatggtga ctgccctagt actgaaaaat ttgtcttact atgctgctgt agagacattg 264181 ccttgtccca tattttttca ccctttggtt taaatttatt caagagggat gatgttttcg 264241 ggagcgaagg agtcagggta ctggaggatt gctgccgctg cagagaggat tgggcatcga 264301 tattggttgg aaaggtggtg tttattttat cccagcaatc gcaagagttt gatccgattg 264361 aatcataggg caggtcttta atatttggta aaagataata gggatcgtac ggtaacagtg 264421 cgcttctttt ttggcaatcg agaatccatt tgaaatgtac aataggtata ttttgttcaa 264481 tagcagcgtt aactcttgct cctagtaaag tatccgtaac aaaaatggat atctgcccat 264541 tctgaccttg atcatcgtca tcattgtgtg aagaggtatc tttgattaca aagttttgat 264601 agttataact agaacaccct aactttttaa tactcctaac caatgaatcg atggaagtta 264661 tgttagtgtc ggttattctg ccaatgaaga tattgaagtt atgcaaatat ttaaacgaaa 264721 atcgccggta aagtatcttc agcatctcat aggtggatcc tgtcattgtt gccgtattag 264781 agtccggcaa tatattttct ccagacagcc agagctgata aatgtcatca atggcttgaa 264841 tgtcaataaa tatgatatcg aatctatgct tcaccgcaaa tttaaatttg tttgtattgg 264901 tggtggaccc aacaacaagg acattaactt gtctggtcaa atctttagaa aatatacctc 264961 ctaacttaat aattttcttt gatatttttt tagctaagat ttcattattt attgcagtcg 265021 gacaaaatgt tattccttga aagggcttca tagtaatatt aatgctactg ataaaatacc 265081 tgccatacta gaaatagaag acttatatat cacgtaaaat ttgtctcttc ttattcatca 265141 tgtacataaa acagtacaaa cattaccaat agtactatat agctttacca ggcaatacgc 265201 gaatagtcca tgcagttttt cttctcttat actgatgagg gtaagttttg catttgatca 265261 ccgccgtatg cgaagcggaa agagcaaatg cgttgaaaga aacctggcga caataggaac 265321 cacgagttca agctaataat gatacctcaa tgattatgcc cagattacgt tatgtgacta 265381 aagtagaaag gtgaataaat ataagtaacg aaacaaggtt acatggactc ttcaattaaa 265441 gaaggaaaag gaaggattct tttgcaggca gaaaacattg aagttatatc gcaacaataa 265501 cgatgtagtt attatgacct cataatatga gaactttttc ctcaagtatt tttaagttat 265561 tctgtgtgtc atgactctca cttcgtcata ttttatgtta gtgcacaaaa tgcgaggtgt 265621 gggtgcaatc aagactccga tccattttcg ccgttcgacc ggtgttttgg cggctaaatt 265681 taagggcgtg atctcagaac tcggcggcaa aaaaaaaagt atataaggca gaaagctttc 265741 tgcctctccg atttcctctc ctttgttttc ttttccgctt caatttacaa tctagttcag 265801 cggctaatcc tctttaccat tgttttccgt ttatcctttg ctcattctcc tttgctcgat 265861 ttcttttgct cgtttttttt tttttttttt gcttcttttt ttcttctcgc tactctgaat 265921 agacgatggc caagaggaaa tatggcaggt cttattccct cgatgataca gattcctgca 265981 gcaataaagt cctgatagta ccaaccggtc aaagctcctc taacgcaatc actgatttct 266041 ctgtcagaaa ggcgcatgct tgcgatagat gcagactgaa aaaaatcaag tgtgacggtt 266101 taaaaccgaa ctgttcaaac tgtgcgaaaa ttgacttccc ttgcaaaacc tcggataaac 266161 tgtcgaggag aggtcttcca aaggggtata cagaactact agaaaaagag gtcgtccgtt 266221 tgacaaatat gaatgcgagt tccagcgcca atgcaaattc taatttgccg ttcattaatg 266281 atacatttta ttgttttgat aattacaaca ctcagtctga aaatcaaagg tttttgggac 266341 atttgacatg gaatattcta actaatactt ttcctactca aaaagcagta gtttttacag 266401 acgatcgaaa taatattgat ctacaactgc aactgttaac aaattttttg aacctgaatg 266461 gtgactttaa tcatctccca aattttcttt tacttaaata tgattataac cttcagtttt 266521 tgaaaaattt gttgtctgtc attattaaag atttttttaa aaggcaaaat tctttgctac 266581 ttctattata ccctacaaat ttatggaaaa atttgctatt agacaagatt aattcaaccg 266641 caatgacagg tgaacccata actctactgg cgttacttta tattattcaa tttacttggt 266701 cttgttttga tgatttcaag ctttttaaag tcacgaagct tattgtttct ctgacaacaa 266761 acagcaaatt agacttgaaa gttttgcaat tggttaactt atccatcttt tattttatgg 266821 gcgcctctgt tgactcttgt aaaagtaaaa gctcgttaac agaacattca aatgtaaatt 266881 cagtaatatg gaccaatgat ttgctaaacc taaactttac aaatattttg aatatgggat 266941 tgtacataaa tcccaaaaat ttaattccta tatcaggcaa caataataat aataaatcta 267001 atgaagagga tgatagaata gtgacatttt ggtgctttca attcttaagc tcatggtggt 267061 ccttaattca aggtttacca aagtccaact ttttaactga agaatttcaa ccgaaatcaa 267121 tctcggttct agaaatcccc aggctgaagc cctttgaaat tttgttaaac ttcatcatat 267181 attctttgga tggatgtaat ttgttgaata tctcatcttt aaatgtttcg gacccaaatt 267241 tccaattttt ccagaatgaa ctggaaagct ttaaaaaaaa tttattactg tggaaccttt 267301 atcacaattt gagtgatcac gataacttcc gattcttaac atccagttca aataaaaaac 267361 taacaacaaa tttactactt aagaatttga cgggtctaaa tcacaaactc aatcaacctg 267421 attttgtgga gattcaatta actttatttt acttgagttt aaaattaatg actttaaagg 267481 aaggggacca agatttgaag aaagaggata tctcgttaga gatattgtcc ctatattttt 267541 taattcttac agatgactct aataatgatg ataatcaaca gttacaacca cagcaactaa 267601 atctctacca ttttacgccc ttcaatagta ttgacattat tgacttatgt ttaaacaatt 267661 taaacaattg gtcattatca cttaaatacg aaagtggtca aaaccagccc cactcaagta 267721 aaataaagtt tgaaaaattt caaaactttt taaatcactg gtgtccaata tggtactatg 267781 atgaattttc cacaaaccct tttttacaaa tcctcaaaat caatttcaaa ttacttcctt 267841 ttgagacaat ccattactca caagaagagc aacgattgtt aataagtttg aataaattga 267901 gatatttgga tgccgtatcg agctttaatt caagttcagt caagtcgaat ttcgcgtcta 267961 aggtcaatac ccagctaaac cttttgcaac actcgagttc taactccaat ttcctagatg 268021 cgtcaccata cgattttaat aaaattttta tgaacaactt tgaaaactat gactacgaaa 268081 cagatgaagg atatgcggaa gatgatgatg aagaggatag tgacagtgac aatagcttac 268141 cactagaaat tccttttaaa aaaagtaaaa ataaatgcaa gaataggaat aaagagcttt 268201 cacaaaggtt atccctattt gaaaacagag atagcaattc ggtagatttc aacacagata 268261 caaatttaaa tttaaaccct gattcgccat cagttacgtc ttctaagaaa aaatatttag 268321 atcatattat tttagataac cgagacatcg ttagcaacca tgactccagt aaacaaaaat 268381 tcaagatcca gaatattttg aactcgacct tctaacatta cgctccttcg tattactcat 268441 tcagctcttc ctctgatagc agtgaatttt cgagggtcac gtcgtgactc atatgctttc 268501 ttgttccgtt tcgtttcgag atgacaaaaa actggtcatt ttttccgtta agtgcaactc 268561 acagcagtat cggccgctga gaaatgcccg gacaaatttt tttgagccgg attggtcacc 268621 gtttctttct tcggcgcggc ttcccattcc cgtccatcca aaaaaatcta cctatataaa 268681 tcgacttttc acctctaaag gcagtttatt ccttgtatgt cctttaagta cagttaataa 268741 cgagcaattt tttttttttt ttttagccat ctacccatca acttgtacac tcgttaccat 268801 gtcaaccaca gcatccacgc cttcatcttt acgtcatttg atttctataa aagatctttc 268861 tgatgaagaa ttcagaatct tagtacaaag agctcaacat ttcaagaatg tttttaaagc 268921 aaataaaacg aatgatttcc aatccaacca tctgaaacta ttgggtagaa ctatagcctt 268981 aatatttact aaaagatcaa ctagaacgag aatttcgacc gaaggtgcag ccaccttctt 269041 tggtgcccaa ccgatgtttt taggtaaaga ggatattcag cttggtgtca atgaatcatt 269101 ttacgatacc accaaggttg tatcatctat ggtttcatgt atttttgccc gtgtgaacaa 269161 acatgaagac atacttgctt tttgcaagga ttcctctgta ccgatcatca actctctatg 269221 tgacaaattc caccctttgc aagcaatttg tgatctttta acaataatcg aaaacttcaa 269281 tatatctcta gatgaagtaa ataagggaat caattcaaaa ttgaagatgg catggattgg 269341 tgatgccaat aatgtcataa atgatatgtg catcgcatgt ctgaaattcg gtataagtgt 269401 cagtatttcc actccccccg gtattgaaat ggattccgat attgtcgatg aagcaaagaa 269461 agttgctgag agaaacggtg cgacatttga attaacacac gactctttaa aggcctccac 269521 caatgccaat atattagtaa ccgatacttt cgtttccatg ggtgaagaat ttgcgaaaca 269581 ggccaagctg aaacaattca aaggttttca aatcaatcaa gaacttgtct ctgtggctga 269641 tccaaactac aaatttatgc attgtctgcc aagacatcaa gaagaagtta gtgatgatgt 269701 cttttatgga gagcattcca tagtctttga agaagcagaa aacagattat atgcagctat 269761 gtctgccatt gatatctttg ttaataataa aggtaatttc aaggacttga aataatcctt 269821 ctttcgtgtt cttaataact aatatataaa tacagatata gatgcatgaa taatgatata 269881 cattgattat tttgcaatgt caattaaaaa aaaaaaatgt tagtaaaact atgttacatt 269941 ccaagcaaat aaagcacttg gttaaacgaa attaacgttt ttaagacagc cagaccgcgg 270001 tctaaaaatt taaatataca ctgccaacaa attccttcga gttgtccaat ttcaccactt 270061 ttatattttc atcaacttca gcagattcaa ccttctcaca tagaacattg gaataaacag 270121 ccttaacacc actttcaagt ttgcacagcg taatatgagg aattttgttt tgacaacaca 270181 accctttaat tttctcattg ttttcatcaa ttatgcatcc atctttatct ttagacagtt 270241 ccactacaat agcaatgatt ttttcatccc aacatagttt ttcgagccta aaattcagtt 270301 tgtcggtcgt ttttacctgc gtattttggt tattaccaga gccttgtgca ttttctatgc 270361 ggttgttatt gtactccgtt atctggtcag tgtatctgtt acaatatgat ttccacaact 270421 tttttgcctc tttttcacgg gacgacatga catgacctaa tgttatatga agttccttct 270481 gaacttttcc actagctagt aaatgcttga atttctcagt cagctctgca tcgctagcaa 270541 tacacctctt gaccaattca ataatttcat cgtagttttc tattttagct gagatatatg 270601 taggtttaat taacttaggc gttttttgtt gattattgtt gcctttacca actatttttc 270661 tcacagtagg tttgtaatct aagctccttc tgaacgctgt ctcaatttca tcatctttcg 270721 ggatctctgg taccaaaatt ggataagctt tatgaatttc attgaggatt tgtttcgcat 270781 tggttaatga agagtctgct tgtccaaaat ctaactctat cattaaatca aacatattat 270841 ctggtgattt gtctaaatta acaggttgat atcttttcaa aaacccattc atgatgccta 270901 ccactttctt ctctcctaat tcgtcccatt taatactttg gtgattgtta cctcttttga 270961 ttactctttg cagtgttatg tctcttattt ccgatagttt gtcatatggc gcgaatgaca 271021 cgccgattac cttgatgttc gtatcataca ccaaataatc ttcttttagt tcattcaacc 271081 attcaaataa ttgctttctt tcgcggaatt ggtgattgtt tctgtcaact atgacacatt 271141 tgatttcttt tttggataat agttccaatg attttttcat taattgagat ttatctttac 271201 ctgtaatatc atcattttga atatgacccc agctgtcagg gaacaaattc actaatgtct 271261 gggaagttgt tgttttgcca catccaataa ctgatattgg aaagattaaa aatttagtgc 271321 gttcgtctac tttatcataa tcaatggcgt tttttaattc caactcggcc actttttcgt 271381 ggtttaagat ttccagccca ctcatgccat atgattgtag aaacttattt ctcaattcaa 271441 tcacaccaaa acctttcaag taattctcac agatcttggg tgatgactcc aatattggga 271501 ttgcgaaatc aagatacttg ttggttataa atttatgctt tctaaattta aacactcttg 271561 acttgttgga aatatagtct ttagtaactt ctctccactg acggtacatc aaatacggtt 271621 cttcaaattt atacttgaaa aaaaatggct tttcagtact cttcaagtgg cacctgataa 271681 caaaaccttc aatctcttgc ccttcaaaag atccggttgc agagcagtta tctaggaact 271741 ttttcaaatc ctccaaggtg ttcgatgtaa tgcattggac gcacctgaat ccgtatttac 271801 tcgccatttg cgaaacatct ttcatatccc aagtttcaaa ttccgcttta ttaacattta 271861 caccatgtaa gtataggcca gctttttcaa ggggatactc taagatgtgt tcttcaaatg 271921 aatcatcgca atattctgcc acagcggtga cattatgggt atatagcatt ctagcaaaat 271981 cacttcgatt gatgttcatt gccgccagtt gtcttaaaag ttgcttctca cctgcttctg 272041 catggttcct gtctacgtct gctctgggtc cagtagaatg cttcgaacaa actaccaagg 272101 taccatcttc taaaccagat ataaaaatga tacaaccatt ggcttttata gtgacatcgt 272161 aaggccctgt acagttctct tcaatccaat tccacttggt aaagttgacc tcgcctacat 272221 tgaaaaactt atcgtatcct ctagcaacaa taactggatt cgttgtatca tcgctaataa 272281 ataagcctct tgcattacat ggcaaagtga tagtattttt gccataatcc cattcgttaa 272341 atttccatga aattactttc ttattgctgt gtgataagtc acaaaccctt ctataagctc 272401 tgcctctacc ggatagtttt tctgcctttt ctaactcgtt aacaagctga gttactgttc 272461 ttttaccgtc atatgggcta ggcatcgctt cttcgtatga atacttttat gatcactaaa 272521 gtcaaagtgt agattttcaa agaaagaaag actatgcaaa tgcgtaaaat ttgctcgaag 272581 caattctcaa cagaatggaa tgaattagat gctcttctgt atactttctt tgggataaac 272641 tcatagtgaa attttatcaa tggaaaagta cgcggccggc ccgctggaac ataaagataa 272701 tttactgaaa cagtgtgctt aaacgtattt gaaaaccaag gtgaatgtac ccttaaagtg 272761 ctggcagtga atagcaaagg tccattaaag tgttctggtt ttataatatc aaaagcattt 272821 atagaaatgc ccgctgaaat tgacattgat gaagctgacg tattagtttt atcacaggag 272881 ttacaaaaga caagtaaact cactttcgaa atcaataaat ctttgaaaaa aattgcagct 272941 acatccaatc aatccagtca actcttcact cctattcttg ctagaaataa tgttttaacc 273001 acattacaaa gaaatattga aagtacattg aattccgttg cctcagttaa ggatctagca 273061 aacgaagctt ccaagtatga gatcatttta caaaagggta ttaatcaagt cggtttaaag 273121 caatacaccc aagtagtaca taagctagat gatatgttgg aagacattca gtctggacaa 273181 gccaatcgag aagaaaactc agaattccat gggattttaa ctcacttgga acaattgatc 273241 aaacgtagcg aggctcaact aagagtatat tttatttcaa ttttgaacag tattaaaccg 273301 tttgatccac aaatcaatat caccaaaaag atgccatttc catactacga ggaccagcag 273361 ttaggcgctt tatcgtggat tttagattat tttcatggaa attcagaagg ttctattata 273421 caggacatac tcgtcggtga aaggagtaaa ttaatcctca agtgcatggc attccttgaa 273481 ccttttgcca aagaaatcag cactgcaaaa aacgccccgt atgagaaggg cagtagcggg 273541 atgaacagct acacggaggc cttattaggc ttcatcgcca atgaaaaatc actagtagac 273601 gacctctact ctcaatatac agaaagtaaa ccccacgtct tgtcacagat cttgtcgcct 273661 ttaattagcg catatgctaa gcttttcggt gcaaatttga aaattgtacg aagcaacctc 273721 gagaactttg gattctttag ttttgagcta gtggaaagca taaatgatgt gaaaaaatct 273781 cttcgaggca aggaactaca aaactataat ttattgcaag attgtacgca agaagtacgt 273841 caagtaacac agtcattatt cagagatgcc attgatagga ttatcaaaaa ggcaaattct 273901 atttctacta ttccttccaa taatggtgtc actgaagcaa ctgtagatac catgtcaaga 273961 ctaagaaagt tcagtgagta caaaaacgga tgtttaggcg ccatggacaa tatcacacgt 274021 gaaaattggt taccatccaa ttataaggag aaagaataca ctttgcaaaa cgaggcttta 274081 aattgggaag atcataatgt attactatca tgttttataa gtgattgcat agacactttg 274141 gcagttaatc ttgagagaaa ggcacaaata gcactgatgc ctaaccaaga gccagatgtg 274201 gctaatccta atagctctaa aaataagcac aagcaacgta ttggattctt cattttaatg 274261 aacctgacgc ttgttgagca gatcgtggaa aagtcagaat taaacttaat gttagctgga 274321 gaaggtcact ccagattgga acggctgaag aaacgttata ttagttatat ggtatcagat 274381 tggagagatt taactgcaaa tttgatggat tctgtgttta ttgatagtag cgggaagaag 274441 tcaaaagaca aagaacaaat aaaggagaaa tttagaaaat tcaatgaagg attcgaagat 274501 ttagtatcaa aaacaaaaca gtataagctt tcagatccat cattgaaagt aactttgaag 274561 tcagaaataa tatcgttggt tatgcccatg tatgaaagat tctacagtag atataaagac 274621 tctttcaaga atcctagaaa gcatatcaaa tatacccctg acgaactaac tactgttctt 274681 aaccaattag tgagatagat tgcgaacatc acttttcaaa aagcaaaatt aaagaaaaga 274741 acgtaccata aacagatata aacatatata tgtataacaa ttagagtttc taatatttta 274801 tgtttgctct ggacgccaga tgtaagaaca ggaagggatg acgtaggaac cttgtgctag 274861 actaaagggt actctcattt atactttgta atccagattc attatctaac gtattaatca 274921 gtactttctc gggtgaagaa agtcttgaaa taaatctttc ctcggaatca gaattcttag 274981 agctttccgt taatcctgag ccctgtgtga aaatgtcatt attatgatct gattcggcag 275041 aattttgtgc attagctgca ttcaagaaat tctcgttact tcccaaaagt ggagaaaact 275101 gattgttatc gttatcgttt tgtaaaggat gccaagcaga ggaatttcta gcgtacggcg 275161 cagtgatatc aatcgtagta tctactgagg gttcaagtag atcaacgtat gaatcattag 275221 gccttaaaaa ggagtcttca ttaactttat tagtcaacgt ttccgtttta ctcagtaatg 275281 gttccatgtt caacttgtcc ttgcttatat taattcctga atagtcaaaa gaggatctag 275341 ctgaggcggg ggtgctcgaa gtatttgtag aatgtcgatt tagttcattt ttatcatgat 275401 ttttaagttc gtcttctatt aaaacttgat ttaaatctgt gaaaaaagga ttatcgtgtc 275461 ttattgtgga cggtaaatta tcttgaacac tttcccttct attcaatgat cttaatgatt 275521 cattgctcag atttcctaaa gctgaatgcg caaatccgct attatttggt gagctatgta 275581 atgaagacga taggcttaat actctttttc tgttcttttc gttactttga ttcccagtgg 275641 atgtcgagtc tttgctttcc tcgcgttgtg gggttgataa acttttcacg tccctatttt 275701 ctctcttttt aggagttgtc tctcttttgt gtttattttc ttctatcttt gacatcgatt 275761 cttttttatt caaagtttct gaagaattct tatccgaatt tttatttgga tgggaagctt 275821 ttaaacttgg aggcgtcgga tgtttggaat taggcctcct tttttgattg ttgtcatgca 275881 acacagtatc cttataagat ggtggatccc gtggtaagat gctcgactct gatgaagata 275941 cctcagtagt agtggttccg gaagcagcat cagatatgaa atcggaagaa aagtcaaaat 276001 ctggcggagg cacttccata tttgacattg gcgatgttat tggagagagc gggattgcct 276061 ggggtgatgc taattctctt tgcaaactct ccggttgata tatgttggat ttcaactttg 276121 cagaattgaa gatggtatta tcactcggat gggattttga gttcctattg aattgcctag 276181 agtttctggt caatgaagtg gaaggtaaat gtgggattaa aatgtctaat ggttggacat 276241 tgggcgaaag tactggagac gaaaggactt ccttgggaaa gaaaatatta gagttatggt 276301 atagatttat attgtcatca gacgattcca atattgagga aattgaggaa tctgtttctt 276361 ttggaaaaga agcaggatgt ccatcatagc tcggtaaaag ggtatttgca tgcgagcaca 276421 atctatgtaa aacatgtatt ggcgagtcaa tactaatttc gtaatgtttc cttttattat 276481 ctactactct agacagtctc aggcaaattt taatccaatg gtttgctttg atgttttcat 276541 aagaagtatc tggatgcaat tgctgatggt tgttgaaacg actcggaata aaaatctggt 276601 actcatactc tttattcact aaatcaccat tctttggatc ctgcaacagg ttccccatat 276661 tcttggcctt tgacaaattt gcatcattgg gcaagttcgg taatttagga cctttctgtt 276721 ctgtcaataa aaatttcttg gtgggctcca tcctatgaac cttcttttct ctacaataat 276781 actccattgt ctctgtcaca taaattctta ttctatgcaa cgtaacttta tcgaggggag 276841 cgaatttgaa cgtgataggc agaaaagcat ctaaaataat atcctttgat gctataacga 276901 tatcataata taattggttt tcccaatctc tagatatgat aatcggctca ctttcttcca 276961 cagaattatg agcctgtgtc cgtacgatat taaccacttg ccgggcgcta atgtttgatt 277021 taaaggcacc aggtctctct atactggcaa ataagaagta ttccacaaat ccgaaatcag 277081 ctttaataga ttctgggtat gcttgaggaa ttagttcttc gaaagcataa atatagtcgc 277141 ctggttgaaa gacaaaaaat tctcctccag acccgctggt gaagttgttg cttgtcattg 277201 ccagatgatt gctactggtg gggatatgat gaccatgatg cgatgctgca tcattatggg 277261 taaaggtgtt attcaacaag tcggaaaaga tggaagtggt cgtaggttta tagttgtggt 277321 gagacacgga aggagacgtg gctctcttca ataaatttat cggggatagg tttcttgatg 277381 gtccattgga agaagtgact gacgaagatc tagatctttg tctactttct ctgtctttta 277441 cgttgacaga ggaatttcca ggtgcaccta gaggtgacaa gttcaacgag gacaaacctg 277501 atatagaatt ttttctgctt gttatagttt cattatcaga cagtgttcta taaagagagg 277561 caccactttc cttcgtcaaa aaattattag ctgcattgtt gctctcatta ggtgcggaag 277621 catccatctt tttcttgctc ttctgttcag ttggcggata tagagcccat gtatggtcta 277681 caatatcttt gatttccacg aattcttgtc ttttaggagg gataccttca ggccattcag 277741 ttctagaata tcctttgaac gaaagactta tgcttttcag ctttgtgggt ttcagtattc 277801 ttaccactag acagccccga agaacaaccg agggatattc cgtcttctga gggtcaaagc 277861 cttggaggaa aacaactggt tcagctaaat gaataaaaag ctgtaatgat gaactttgtg 277921 ccaagggtgt agcatcgagg gggatatcaa tatccttttc catgggaaac aatggagatg 277981 agatagattg gtccatgggc atcttgaaaa atgactgatc tacaatgaga aaggctggaa 278041 aaaaaaaaaa gatgtttcaa cgttaaaaaa ataaaggact aacggtaatg aatagcgaag 278101 tctacagact aatttgccct ttttagtctc tctcaatact cacagactgc ttgtagcgta 278161 attagtacct attcttaaaa gacgaaaagg agaactagcc aagtcttttt tttttcccaa 278221 attggaccat atcggattaa atttcttttt tccgaaactg caaatcctcc agagaatgtt 278281 ttaataaagg aaaaccaatg aaagacattt agcagaataa caaagcaaaa agaaatgaca 278341 gtgaagagtg ataggtgaag gcgttgagaa atgagagttg ttgccatgga ggaatgggta 278401 ctgaaccctc tcacagaggc gtcactaatt taaaaaagga aaaaggtgtt atatgtattg 278461 gggaaaggag cgatgaattt ttgggtgatg aatgaaacag tgggatgaga tgaactacag 278521 caatatggtt tggtcttaac ggctgtcatg acaaactatt gatcagggcc agtatttgta 278581 tcattattgt tataattgag aatgaagaaa ggttagccgc tgagagaacc ttcttcaaat 278641 tatgtttttt ttgctttttt tctttttggg acggcgcgcg atagatggcg caagggagtt 278701 gctctccgtt cgacatcaat aaattggtta taaagtgacg tatttggttc ctttttagta 278761 attgatgaag agtgcgggat ggcctataca aggaagagtc gatttagtgc cggagaatac 278821 acgccctgac gtttgtataa atgcatttcc ccaaaaaaaa gcattccgga aatctctccg 278881 tggtggaatt gccgaaggaa gctctccaag attctttaac tgctgctcag attactttca 278941 agagatatgc ccaccccaat ggcaatgccg gtagcgcaga gaggccgaga catctaaagg 279001 tggaatctgc gcctgtcgtg aaatctgagc cttctttgcc gaggatgaga caaccggaac 279061 cgagaagtat aaatcatcaa tactctaggg aaacgcttcc aggccattct gaagcctttt 279121 ccgtaccgac gactcctctg cagacaatcc attatgatgt aaggaataaa gcgtcaaatt 279181 cgccaagtag tatagcagct gcagagacag ctgcatacct agcccacaca aattcattta 279241 gtaacagatc atccggtgtc ggcagccggg atccagttat ggatactgaa acaaaaccgc 279301 cacgtgctcc ttcagccttg aaaaatgagc tgcaattgaa cagaatgagg atacctccgc 279361 cgtcatatga taataatgtt cgttcacgat ctatttcgcc acaagtatcc tactctacct 279421 cgctgtcatc atcgtgttcc ataagttccg atggagaaga aacttcttat agagaaaaaa 279481 gcaccgatga ggcatttcct cctgaacctt ccatgtcttc ttatagtctt gcgtccaaag 279541 cctcagcaaa ggcttctcta acggacccct cacagcggca gcaagagtca gactatacgg 279601 caatgaataa actcaatgga ggaaatataa tatataaagg cactttaccc gacctaatac 279661 cgcgaagcca aaggaagaca agtaaaccca ggttcaagca caggctttta cgatcacctg 279721 agcagcagca agaaaactta tcacgtgtgt attcggacca aacgcagaat ggtagggcaa 279781 tcataaacac gcagcaaaat gtaaagttaa agacaactat gaggcgcggg aagtacgcaa 279841 ttacagacaa tgatgaaact tttccctacg acagaaagtc tgtatcatca gactcagaca 279901 cagatgaaga ttctaatgtg atggaaatca aggacaagaa gaagaaaagt cgtcgctcta 279961 agataaagaa ggggttgaaa acaacagcag ctgtagttgg gagtagtacc tctgtccttc 280021 cgttccctca tcaccatcat catcaccatc agctccataa cccgaattct catcacttac 280081 acacgcacca tcatacaagt tctcacaaat tcaatgaaga taaaccgtgg aaatctcata 280141 gagatctcgg gtttattacc gaacaagaaa gaaaaagata cgagtctatg tgggtatcaa 280201 acagatactc gtatttgcgc ttgctgccgt ggtggccctc tctcgcgaat gaagacgacg 280261 agtctcactt acagccctta aatttaccgc aagacggcct gatgcttaac ttagtcgtaa 280321 aagatatatg gtatcgatca aacctaccca gggatcttct agtgcaaata tacaatatgg 280381 tcgacacaag aaaagacggt accttagaca gaaaatcgtt tatagtgggc atgtggctgg 280441 ttgatcaatg tctctatggc cgaaagctaa cgaatgagct ggaccagaga gtttggaata 280501 gcgttgacgg ctatgttctc ggtacaatta acgtgaagcc tgccacttcc gatcactatc 280561 acaacgctaa taaccctcta gataagccat caaagctttc agtccgacag gaattgaaaa 280621 acatcaaacg cgatctcaga aatgtcagaa tatgatgcct ggcattattt gcagaagttc 280681 tcttcctgtg ttaataatga atgacgatga gttaacaatg acccttatgt atacaacgaa 280741 aggacgaatg aaagaaatga aaatattatc tttttttttt tttttctcaa ttttccttca 280801 cttttagaag tttttccgtt ccgcggattt tgttcgtcgg accttttgct ttatttgtct 280861 ccagatctct cgagcataat ggtcgttttt catttcatgc ttatagtctt tgtctttcca 280921 gcggtacccc caccccctat cttgggctat tttctaattt cgtccctcgg attatttaat 280981 tcatattctc cccacctttg tattactaaa tttattttcc aatgctcttt tcactcattc 281041 ttccttttgc atatttctat cagtatatat agcgaattgt atatataagc gtcttgttac 281101 cggtatagga attacctgat agaaagaaat agaacataat aggaggaagg gcaaacagtg 281161 cgccaaaacg aaagatagta gaagatgttt agagtatttg gttcatttgg atcaaagggt 281221 aatcaatctt ctggtgaaga gcaatcaaca aagacaaaac aggttctgaa gcaggctaat 281281 gactttgaga tcgccttaaa ggcaatggat tttgtccttg atgatagaac ggatgaaggg 281341 ttgaatttgc tgaaaaaagc tgaaatggaa actggttcag atcaaactat cttgactttg 281401 gcaagaggtg ttattgaatt tcttcaagcc actttgagtt ttgaaactga agaaatgaaa 281461 agagctgcaa ttactttagg caaagctgag caaatgtcct ggaaaagtaa gcaaaatgct 281521 gaaaagacca attttaggag cagttcaata tatcctcccg gtactgtcta tgctgtaaca 281581 tatactgagt catgtctgtt gcatgccttg ttgatgttat ttagtgaaag catgatggaa 281641 gcagccaagg ctttgctaaa gttaaggagg gcttatacaa tgttacaaga tatcatggtt 281701 actgtcaaaa aagctgaacg atcgaaaaat tcgagctctc cctctccaag cgaaaagagc 281761 caagagtcat gcggaagttt tgtttctgca gagacaactt tcatatcggt tgatatacca 281821 tacaaattgt cttccgagga caagtccaat ccactcctat tggaatttgc tgaaaaaatc 281881 tacacgatga gaatgggaag gttatcaggt gcccatattg gcaatactcc atcttttcat 281941 aggttaaggg atgatttggg tttacagacg actccgtctc aagcttccga ccgccattct 282001 gtttcagatg atttcgattt agaacaggct accatcgacg aattcatcca ttcaggtgct 282061 aatttatgct atggtatctt gcaagtcgtc ttatccttac ttccacctgc aatcggtgct 282121 gtgctatcta ttgttggatt caagggatcc cgtgaagaag gtttgaggct agtttggaag 282181 gctacaaagg agagaaatgt tcacgggtgt ataggtttgt taggtctgat gttttattac 282241 gacggtcctt tccaatttac agatgctgac tttgatatac caccaaacga taatggatcg 282301 agggctttaa acaaaagcag aacaaacgat agtagccttt taccaggtta tatggacagt 282361 gcaaccttat tgcatcctgg aaaaattctg gaggacgcat tactaaaagc aagagcactt 282421 tttcctaata gtgccctgtg gctgctaaat gaggccaaaa tgcttgctgg aaagggcagg 282481 cttcgtgatt ctctggccct aatggactct attgatgtca atagtatccg tatgagacaa 282541 gtgaaatcgt tgatggtgtt tgaacgtgcg atccttttag tcaacttaca cgaatacaac 282601 agagctgccg atgatttaat aagtttgctt gatattagtg attggtctca cgcattgtac 282661 acttattttg cgggttgctg ttacttggaa aattggagga tgacacaatt aggcttatta 282721 aatgacggta aagaacaatt ctataaagag cgggctcgag aactcatatt tgacgctcca 282781 tctttgttag gtaagaaaac gttcaaatcc aaaaatcttc cattggatag attcatgctt 282841 agaaaagttc aacaatttaa taatatgcag aagaaattaa acctacaaga accactagac 282901 tcaatagcaa catcacctgt ccatgaactg gcttatttct acaacggtta caacaggatg 282961 actgaaaacg atttaatttt gaccaaaaag atgttgacag agtatcacaa ccccgccatt 283021 gattcggaag acccagatca agagctgatc agaaacttac tactatcctt gaccttaaga 283081 agattggggg atgctgaaag aggtttagcc ttgttagatg acattgttct gccaaaaata 283141 ttctacattc aaaatggcaa agtcaaatat ttcaaaaaaa ccgaagaccc atgggcatat 283201 ccagccgctc tttatgagag agctttattc tgttggaaac tgggtggcat ggaaagtttg 283261 aatgaatgta gggaatggct gctaagagcc caaaattatg ccgccgatta cgaattgagt 283321 acgcgtatcg gtatgaagat caaagccgcc cttgatagag ttgaaaacgc gcttgcttaa 283381 ccttttgctt cttccgcccc aacattttag aagtatgcat tttttttttt ctttcgacta 283441 cttaccttcc cttgctagca gttattacaa ccatcatttt ttcgtgacgt ttcatagttt 283501 ttttatattt ttacgcaatg ggtttcccga gtagttagtt ctacggtgtc gatatatata 283561 gtgttatgat tttaaaaatg aacatattta aatttttgaa cctccttctt agttataggc 283621 caagttcatt actccctagg aaacaaaacc ggtccatcgt agaaattttt tttattttac 283681 aaaagggtta tagtagaatc aagacaattt atttatcact gagatattga tcgagtagat 283741 gaatggtcgc tcaaactgct aaactgaaag gcgacttgtc attcaacaac gttttctatt 283801 cctatctaaa cctatcgtta agcaatcttt cgacgcccac ctcttcgtat tcctttttcc 283861 caacccacag ttggtgaaat gttcccagac ttgtaagtat actaccgcca agccatgact 283921 ggtattgcct ttcgatagtg tgccctgttg ttaatattct aaatttaagg gatggtagta 283981 ttttgtttag ttctgtcatt aacctatcac ttaatccagg aatagaggat gtaccgcctg 284041 taaggacaac attatgagct agtgtcgctc ttagatccac atcactgctc attatagacg 284101 aataaacaag atccgctaga ccaatcaatt cattattttc tttaggaggc ttttcttctt 284161 ctaacggtct cttaccggtt tcatttggag tgtctgcact atttgcagcc ggagaagtag 284221 atttgcttac agcttcctgt tccttttctt cagttggtgt aactttcttg tctgatttgt 284281 tcactccgct tggcttggtt ctttttagcg gcacgtaatc attccgccaa gttttcacaa 284341 ctccagagtt cgagcgaggc caatttgctg ggatgtcatc ttcttttgga aggaaaagct 284401 cttcagcaaa gccgtaacga gtttcgttgt caaaaacaat ctcctcattc caaggacttt 284461 caatagatct tttagccgta gaacttaatt ctgttttcgt ttcttccaaa gtttttgttg 284521 ggcatatatg acaaagtgtt tctttgcact cttgaaagaa ccctcggtta ttggcgtaat 284581 catacagcga tttatcaacc tcatagtcga atgttttttt tataaactct ggttttcttt 284641 gcttgattgc gaaaagtggt atgatttctt tgggttccaa tgccttttta atcaagtgat 284701 tgataaattt cccagcaata aaatttcttc ttgtactctt tgataatgtc ataccatcca 284761 ctattggact gacgctgcaa gtatcatgtc caatatcaac aaccaaacaa ttgggtctac 284821 ctgctgcaaa agaaacgcat gtcgatgtgg gtgctaagta acaggcttca aattgcatgc 284881 cttctaagag cacttctaaa gattttttcc tgttttctgt gctattccaa acgggctcag 284941 ttaacagagc tggtattccg gagttggaat tcaaatagag ttcgttctgc aatgcccatt 285001 gccactgttc ttgtgcggta tcccagtcta tgactagacc gttctcgata ataggtttca 285061 gttcataatc ttttcttgga attccaattg attgttcaga aaatattttc ttattgcctt 285121 catctgcagt gtatttaccg taaacagagg gcagaattga ttgagggaag tcagaacccg 285181 aatagccaat atttgttgtg tatgagccag gatcaatgac tactgcggaa acttcgtcgc 285241 cgccataaac ttgcaaagca gcattggaca tagttatgct tttcaccgcc ttataacgaa 285301 gactcttttt ttgcctaaaa tccttggttt tctgtacatc ttgttttctt ttttttcttc 285361 tcgctgtttc gtcgtcttct ccatttctta tgttcgtgtt acttcaactt caaaatagct 285421 ttaaatggga acttttcaaa gaaaaactaa tgtaatctaa ctattttaaa aacgtacaca 285481 tcgtagatat taatggatta tataagtaag taaaagccaa aatctatatt gaaaaaaatt 285541 ggtttcaaag agcttgtcta tcttcttaag gatttcaaaa ccatttcacc ggccttttcg 285601 acaccagctt tggtacctct aatgtacaca acatcattga ctttgtcaga cttccttggg 285661 acgttgatga taacgtcggc cgcttctcta atctttttga tgttagaacc acctgggcca 285721 acaatcatat tgaatcttct ggtatcagca ccccagacgt aaccggcata tgtagcagat 285781 ggtgccttgg caattctttc tttaatcaac ttaacagcag tatcgagagc ttcttccttc 285841 ttagcggaat cgtttgaagt gtcctttgtg acttcctttt cttcaccgtc agagagaatg 285901 ctactcaaat caattggttc atatgtcaac ctcatggtaa tatcaccttc ctcggaagaa 285961 gttggtgcac cgacttcttc gatggtaaat ttagtctttt ctgcattttc gccttcggta 286021 gatccacaga ctttctctag aggaatttcg attggagcac gagctaattt gttagccttc 286081 tttgaggtgt taccaaatct tacattgacg gataaatcca ttctcaactt ttgtatgaaa 286141 gcaccacgtt ctgaaacata ttcataaatg gaggcaggaa catcgacttc tcggtcaaaa 286201 ttttccctga ttatttcatt caagattttc ttctcagctt tctcgacatt ttctggtgca 286261 ccggtaatag ttattttgcc gctagggtca tccttattag gaacgaataa gttaatgtta 286321 aattcggatt ctagttgacg acgaacaatc ccaccagggc caatcaaagc accctttctt 286381 tctgctggaa tatcaatggt cttagtaaca ctattttcag catccttgac aatcttgtta 286441 atttcctcga caaccttttt gacaaacttt tgaggacctt gtacggtaat gtctttattt 286501 tcggagtctg cgttaggaat atcaacagac ttatttctaa tttcttcacc accagccttg 286561 gagataattt ctcttaaaat atgaccaccg ctaccaacaa ttgacttatg gtatttgtga 286621 tcaattttca agacttcagt gacaaaatcg gaggcttcgg caacaatgga ttccacacgt 286681 ttggcggcat cttttatgtt ttgtctagaa ccagtgatct ccagttcaac ctcaccagtt 286741 tcctgagcct ttggatcggt gctcttttgt aagaaatcca tctcaacacc gtattcagct 286801 ctgatgtcgt tgatattgtc accattctta ccgataattc ttgggacgtg ctcagctgga 286861 acattaataa ccatcttatg tccgttctcc atttcaaaat ctaacagagc tttcaattct 286921 tcatgagctt tattgacacc acgagaaggg cctctaatgg tgacaatttc attgtctctt 286981 gggaagttaa tgaagacatt gtatttttcc tgcaaacggt tacgataagt accgtgtgga 287041 ccaatcagac taccatgaaa cttaactgga acaattagtt cctttgtgat gatatcagcc 287101 cattttttgg cttcggcagc caaatatttc ttggcatgag tcaagttgta ttctaaacca 287161 gtcaaagtaa cttcgacagt cttatctttc gaagcattat tgttctcttc gtttggaata 287221 tcaatttggc aggcaaactt ctcacgaatt tgttgtaggt tggagccctt gttaccaatt 287281 aatctggcaa ctgagttggc tggaatatta acagtcattt tgcttttgct cgatggagaa 287341 ttcaaaatag attcaaaaat tttgttagca gctttggcag ctttttcatc acctctaaca 287401 gttaactgat tttcttcagg ggtatgtagt ttaatttgaa ggtggccttc ttgttcagaa 287461 atgtcctcca taatcaattt ccatgtagcg gaagatggtt taaacaatga gtcttgaacc 287521 tcctcggaaa attcgtaagt tttagtctcc atgttgtttt gtttagtacg tagagagttt 287581 aatgactcat tggccttgtt caaagatgct tgaatctctt caatagatgg cttgaaatct 287641 tcatcttcag ttaaagcaac aagtaaaata ctgttatcat ttggataata atcaccgaat 287701 tgaacaaagg caacgctgct ttcggaagct aataaacaat gtttaataga cccgccgaac 287761 aactcgtaat ccaaatctgt gataaccagg gtttcggaag gtggaatatt gttcacaaaa 287821 gaaatcaatt ctttacgaac ggccttgata tcgtttgcct catcagattt tgcgctgatg 287881 tggatggtaa cagtttcagc tgttggcaat gactgtatgg atggtaaaga tattttaaca 287941 ttaggatgag attcttcaag accctttaaa acggagtact tggtgaaata catgattaga 288001 tttttggcat gggtcagatt cttactatga gccttggaaa tatctaaaga ttcaaccaca 288061 tagctctttg aagacgatct ggcataggtg atagcttcac caaccttatc gcgcaaaccg 288121 acaaatgaca caagctcatc atcaggagtt gatgggaaag tgacaatgac attgtatttt 288181 tcttttagtt cttctgcatc aatcaaaaac tggaacttgg atggaatctt gaccttttct 288241 tcgtccaaat tagaagctaa ttttttcaaa taatcttgaa tagatgtctt cgtggctttt 288301 gctttttcac gaggacccaa tatgacaata tcacccgatt ttttatagaa ttggactttg 288361 acctcttcat caccctcatc ggaggcaaac tcggaaacat caatgtatgg taggtatttt 288421 tcatcttcaa cgactaattt gattgtggca ttcttggttt cttccttaac aatggccaag 288481 attttagcct tagccaagtt gaccgattca aaatcaccaa ataaagaaac gttacttgta 288541 gtatcatcca tgtcttcatc atatgagttt tcattgactt cctttgagac attgatttta 288601 acttcgtagg catcactaat ttcacgaata gttctaccac ctgaaccgat aatactggct 288661 ttacatttgg atgggacctc gatgacagca ttgattggtt ttgttaattt cttcactaac 288721 tctctctttg cttcatgaac gttagcagct acaccagaaa ccaaaaaggt acgagcattc 288781 ttagaaagag ttgattcaac agaaacatca tgatttttct taacagattg gacaatacga 288841 gataattcag gtttggtgat tgacaactga gattgcaggt ccaaagtgaa agcctcttgg 288901 atgttctttg aacgcatcct cttggcccca aggccagtag tcaatgaagg agcagaaggg 288961 gaaggtgatg gcgagttaga gacagcaggt ttcatgtttg ggccccagct aaccttaacg 289021 ttcgcgaagg cagcatttga acccaaagaa ggaagatcct tcaaagatgg caatggagtt 289081 ggctttttct ccaactgagg atgttcttca gcggtagcag caatagtgga ggcagtagta 289141 cttggcgaat caatggtagt tacggtttca acagatcctt cgacagtgga agggggagag 289201 tcaatagcgg tttgttcttc agacattgca gttataatgg aaggaggggg tgtgggaagt 289261 atattttaag cgtggtaacc aaaagacaat agacggaaag ttaggaaatc agaatgattc 289321 accttaaaaa ttatgctaga taaaagacag caatttcaaa ggaaaataga aagtgctgtt 289381 gtgtacttag acgttctttt tcaaagacgt tcaattgaaa agctaatagc caatgtttcg 289441 aaggaagttc tgtacgaaat gtaaaaacta taaattagta aatatactat ccgttgcaag 289501 tctttaagag ctacattaaa ttgaaattgt cgagtgtcgc caacaacaat tcgcgaaaat 289561 gagcgaaaat ttttcaagcc caccgctaaa aaaaaaaaaa aaaagaaaaa aagggacata 289621 aatacgtata tctccagaaa atgcccagtg gagtggatga atacctgatg ggctatatta 289681 ctacattatt gaaaacgttt accaaaagtt tcgttactgt ataaaaaaat tggggtatat 289741 aggcgggtat atatgggtat acttagtgaa caaggaactg ctgaagcaga aaaatcctcg 289801 taaaacaatg aagataaaac gaacattaaa tgaaggaatg agaaagaagg atcaatgaaa 289861 acttttcttg aaagttaagc taggggctcg acattatcgg cgtattcgcc ttcgtagttt 289921 cctgcggggt cgtaactaca gatgacatag tcaccccatg caccgccaca ggttttgatg 289981 ccacaaccaa cttgggtggt ggacttccaa acgacttgag taaagtggcc agtgttactt 290041 gaaaagcctg gattcgagaa gtcgtagttg gaaatttcat tgtaccaagc gtcgacggca 290101 gctgggccgt cataacccaa agccaagttt tcaccgtatg gaccgccaga atgggtcaaa 290161 gtgccggagc aatcatagtt gtcagcatag tcttgagcgt aggaggccaa agtatcggac 290221 caggacaaag ctggtgtgtc cttgtgcaaa gctctcttct tgttgtgttc agccaacaca 290281 gaagaggcaa aatctgacag gtcactatcc gaagacgatg ctgagctagt agcagcggct 290341 tgagaagtgg tggtggtagc agcgggtgtg gaagtggtgg aagcagcagc gggtgtagaa 290401 gtcgtagtag cttgagccaa cgattgcgat gtagattcag aagatgtcaa cgtggtcgtt 290461 gaatcggtag ttttacccca aacagaggct aagttcttca aagcagacaa gaccacatcg 290521 gaattgctgg aagcagagga aggagcgaca gggggagcaa ccaaagctgt agctgtagaa 290581 gttggagtgg cagtggaagc aggagctagt gtttcgtaag ttgtacgtgt ttggccgttt 290641 tcgacataaa ctacgccttg cacagtaacg actgcagcct catgggcgtg ttcagtgaca 290701 gtaacaacgg caggagcggc caatgcagac gtggctaagg cggaggttaa gatcgataat 290761 ttagaaagtt tcatgattta tcaattacgg gatattaaaa acgaagaaaa agtaatatca 290821 aagagcggaa gagtgtggcg gcctataaaa aaagaatgaa ttgaaatagc ttacgacgta 290881 gcgatagacc taacggtagc aactaggatt gaaaagagag cgcgattgaa gattccttgc 290941 ttgttttcag aatagaaaaa tagagaatac gaaaagaata aataatacaa tttcgggttc 291001 gttaacagag gtgggtttat atatggtatg ggtaaaatag agaagttaga aattatatag 291061 ttctaaagaa gtagagagtc aatagctgca ggaagcacac gagtgctaca gttgttaaca 291121 cgcaataaac gggtccctct atctaaagcg acacaggtaa tgggtatgcg atccctcccc 291181 ttcgagcaga caggcaattt ttatccacat cgggaaatga ctctgtgcgt acatattacc 291241 tctttaggaa taataattac tgtgattggc gcacgggtgt ggaggtgtcg ctcgtttagg 291301 aaaaaaaatg catagttggg tgttgttcga ggagtctaga aggcgaacag aacagctacg 291361 acaaaagcgg caatcgttcc agctagacta ttgcactgga aaatggaaag aggtgttgca 291421 gcaccttcgt atgcagaaag ttttgcggtg gttgatgtgc cttcttttag ttgagtgtag 291481 atcgaggaag ttggctgatg catggcagac ccgtcttgtt ggctggtagt tgaacgaccg 291541 ttgctaccag tagttgttct tgcacctagg cttgtgctgg agggcttggc atacagtgta 291601 gcaacagtct gttggtaggt tgttgttgtg gaagaggtgc cttcgtttga ggtggatttg 291661 acagaagtgg gctcgtttgg cttttcagat gtggcgaaat cgctagcgag agaagatgtt 291721 tctccggggt taatgatagt tgcggcgttg acttcagtgt agatactaga aaaggcagtg 291781 tcatcatttt ctagacaagt ggttgtagtt gaagggaaag aagaagctgg aaccaccgtg 291841 ttggttttca taggcgatgt ggttagctca ctggtttggg ttgaggcgcc gttcaaagtg 291901 ctacaagatg tcgagattgt tctagtgaag gccgtctcat ctgtagaaga agcagcggag 291961 gtagggaaat tactatccgt actacaagaa gctgtgatgg tgtttgtgat cagattgctt 292021 tcagtggtgg tggcagtgga gatggcgaag ctaggactat cggaataatc gctctcggaa 292081 gtgcaggtag agactaactg tgtggtgttg cttgagacac taatactggt ggttgtgcgt 292141 aagctatcta aagatgcgcc tgtggaagaa gatccatatg tagaggtgtg tttagcattg 292201 tcggttggac tagctgagtt gtcggtaggg tccaatgtgg gatctatggt tactgcggta 292261 gctgcccttg tggagttgtt agcagtagtg gccaaggttg tagtactctt agtaatggct 292321 gtgatggttg tggtactcga attttctaaa gttgtggtct tcacgatact agagcaattt 292381 gtagcaggca cagatgtggc aagcgcagag gattgctcgg atgtaatggc gtattcggca 292441 gcgtatgtta caccgtgtcc tgacacagaa gcactgttgg agtaaatgct actcgatgtg 292501 gcggcactgt tactaatatt cttctctgtt gaacttgaag cctgagcagt ttccgaagtg 292561 atactttctg aggcggttac tgaagtggtg gcggtgtcct ttgtggtatg ggctgtgcta 292621 ctaactgagg ttacagatac gtcggtgttg acggctataa cggaattcag aacagattgc 292681 gacacagctg aggaagagac ggccccggaa gaacttctgg aagatgaccc aagtctcgtt 292741 gcatattggg cagcattagt tgcactagtt actatactag tatgttcgga aactgagctt 292801 gtggcctcct tggaagtgct accctgaata tcgtcagcag ctacagatga tgataatgag 292861 gcgcttacag aagaggttgt ttgagcagaa aacacagttg tgtttgcaaa cttaacagaa 292921 ttaactgaat tggaagttac acttctggag cttgcggtgg aagtagtaag agtactactc 292981 aaaggagcag aaaccattga tgaagagctc gagatggcgc tgctagaaga agcggcgttc 293041 tcggtactcg cgctggagga agcggcagcg gaacttgagg caggatcaga agaagaagca 293101 gcagcagtgc tcgaggtagg gtcggaagaa gtggtactgg acgatgtagc aaccgatgag 293161 gtggtggtag tggatgaagt agcatcacta gagacgacgg tactcgagga ggtagcatag 293221 gaagtagtga cagaagagct tgaggctgat gagacagtgg aggatccaac tgattctgtg 293281 ctactagtaa ttacggtaga agaggacgca gtgagggtag cggtcttggc agggtttatg 293341 gtcgtcgatt ttaaagaact gctgctagcc gcagacgata ccgttgttgt atacccttgc 293401 gctacagcgg gcataatact ggatgagatg gtggagactg tgtctgatgt agttgaggta 293461 gaagaggacg aggatgagga cgaggaaaca gtgcttataa gtggttccac ttcctctgca 293521 aactcaccca ggtagtttcc aggagggttg taggagcaca caatataatt gttccatgtc 293581 gtaccacaat atttataacc acatccaatc tcggcggttg acttccaaac cacctgtgtg 293641 aagtgacccg tggattcaga aaatccggga tttgaataat tatacttgct tatctccccg 293701 taccaggcgt ccaccgctcc cgtgtctgtg taaccaaggg caaggttctc accatatggg 293761 ccatcggaat gcgttaagac acccgaacaa tcatattggt cggcgtagtt ctgcgcatag 293821 gtggccagag tgtcggacca ggtgagcggc gctgtgtcaa catgtagcgc tctgaacttg 293881 ttatgctcgt tcagcacatc gctctcgaag tttggaaacg tggtttgtgc cttgacggct 293941 actaggcatc ctagcagaac tgatattgga aactccagca taagcgtttt cgttttaagt 294001 tgttttaagt tgtttggagt tgcaggggtg cagcaattat aattttatgc cgatattggt 294061 ttggcaacta ccgaaaagca agaagctaaa aactttgaag tatagaatat gttttagaga 294121 attcttcgac cgagttgaaa catgagaact gtttcatcgg ccctatatag caattacatc 294181 cttccgttgc tgggtccctg cctagatacc atatttgttg ttgaattaac cgcgggaacc 294241 cgcaatatac gaaagacgaa cacaagagag caagcacaca cagctagtgc gtagcgttgc 294301 tagctatatt gccatggtac ctacctttca cctccttgtt aaatccataa gtggacggtt 294361 ttcctaaacc agtatttatc agttctcgag cacgcagaga aaagtaaacg aagcgacctg 294421 cattgcggta actataaaca cccagccgcc tccagcagaa ccagccatgt gcgaagaaaa 294481 acaatttttc ggccaaactt accaacaata gcgacgcgtt cctcacatcg ttgggttttt 294541 ttcgcctctc ttcaagtttc ctatacccga gcttaacaca acacaacgga ccctcttaat 294601 tagaggtatc ctccgttctt ttcttccgct ttcctaatcg agataccaga gcacggaaca 294661 ggaccctagt gcatcggaga ggagatccgt ggcacgctca ctgcgccttt cactatcacc 294721 gatttcgtaa ttcgaacagg agtatttcgc tgcaggggaa ttactgtttg tagacgaggg 294781 aaagcaatta tcagatacat gccagggata gcgttcaagg ggaaagacat ggttaaggca 294841 atacagtttt tagaaatagt cgttccttgc cactgtacga cctgaacttt actcaacgaa 294901 aaaaaaattg gaaaaaaaat agtgcataac gttgctatta acagatgtag tactgatatg 294961 tccctgattg gtgaagagtc agaatgatat aagcctattt gatatgtacg tgtacgtatt 295021 cgaaaataag atttgtttct cgtagggagc gatatgtgca ttatgttacc cgttccacat 295081 gttttgaact ttttttcttt ttcatggtaa gcgtcaataa tcaatttgaa taactagtga 295141 agagtagcta gcacgatgaa ataagtgccg gagctgatcg aatccctagt ctcggttcgc 295201 ctgaaacaga gagaagtcga ttactgtaca ccgtgcctcc ttctatgtac aagctacaag 295261 tggtcttggt gcctccgagt cttcaggcga cgatgccaat acagtttggc tacggaccaa 295321 ccatcgccga atcttctcaa ttgttgccaa acagaactaa tatggcgcaa agcgccggag 295381 atgcctcttt gcagtatgct aatctgagat ctgccaatgt gagtttcacg ccaagctatt 295441 tcaaccagtc taggtttagg aagtttcttt tgtttaccaa gccgacaaac acgctgttga 295501 acttgagtga tgaaatcatc gataagtgtg aaaaaatgta cccgagtttg caagaagaca 295561 ttgaaatttt gagtttgcaa gataacagcg gttgtgacct tgatccggat tttttggtaa 295621 aggacgtttt caatgtaaat aatatcgtaa gagttatatt gaagaatgag atagatctgg 295681 acgattccgc accagtgtca ctttataagt cggtaaaacg atccaagttg aacaacgggt 295741 cgccccagtc ggtgcagccg caacaacaaa tcccgtcctc ttcaggtgtt cttcggattg 295801 ccaagaagag gccacctaca ggaaccacga caacaacaac cattcgtagt gccactaatg 295861 gatccatgag ggtttctacc ccattggcta ggcaaattta tcctccacct tcttcgaaga 295921 tcgtctccaa caactcagat gacgaagacg aagacattgg tgaaagatcc tttttgccgc 295981 ctccaacgca gcctcagtca cctcccataa gaattagttc gggcattgac gcaggtaaaa 296041 aaataaaatc aagcatcgtc gaggaagata tcgtgtccag atcagcaacc gtggatccag 296101 ataaaacaaa gcagcaacgt ctattgtccg gaactcctat aatgtccacc atgactccaa 296161 acagagttac tcttaccggt cagagagtgg tttctgaaca cgcacataaa aacgaattgg 296221 ttttctctgc ttcagcttct tcctcttcat ttgctaatgg tggcacagct gctgtcactg 296281 ctcaggacat taataggaaa ccacccgtaa ccactccaag aataacatca ggaatgttga 296341 aaatccccga gccaagaatc tcagagattg aaaaagagtt aaaagaggga ccttccagtc 296401 cggcctccat tttacccgct aaagctgcaa agattccaat gaaaaaacct tacttggaaa 296461 atggcgagaa ctacgaatcc gacgatagct caagtagcga aaaccaagaa actcctgaaa 296521 cagaaccaca ttcaaaggct tccttgcaac gtagtcaaag ctccatcgca gataataatg 296581 gctctccggt gaaaaatagt cctctcggtg atgccatgcc acacaatgtg catttagcag 296641 aacttcccaa ggcaagcaat acctcgatca ccaaatcttc aaatggcgaa tcctggggaa 296701 agcaacaaga acatcaacca ccaagaaaga gttcactgga aactatagtg gaaaagaaat 296761 ctcaggcgga accttccggt attgtggaac cgaaaagaat gactaatttc ctagatgata 296821 atcaggtaag agaaaaagaa gatacgaatg ataaactttt agaaaaggaa attttgccga 296881 caattccaca taatgatcag ccaatacttg catcatctga taagtctaat gggacgttga 296941 aatcactagc tgggaaagtt agttcaaaca acaacgcttc aaaggaagat ggcactatca 297001 ttaacggcac cattgaggac gatggcaatg ataatgatga agttgatact acggttcgta 297061 ttgttcctca agattcagat tcctctagtt tcccaaagtc agatcttttc aaaatgatcg 297121 aaggtgatga tacagatcta ccgcaatggt ttaagggcaa aaattcgaga acttccggta 297181 attccaaaaa ttcaaagcct tacacaacgg ttttgaataa agacatagac aattctaagc 297241 cagatccaag aaatattttg ccccagcgaa ccccaagaag tgcggctaag agggctgccc 297301 aattattggc aggtgccaag aaaaacgaag tcccacagaa aagtactgaa gattctagtt 297361 cggcagcgtc cacagacgat gagtcagaga gtgggattga aacagatttc tcatcagacg 297421 atgattttaa aaggaaaaat atgtcggtgc ctaataatgg gcccaaagac atttctttac 297481 attctttgaa aggcagtgtt gttccagtga aagactcaaa gataatcaat aaagaagttg 297541 atgaagaaag aaacgacaaa agagatagtc aaaaaaagtc agccgtgagt gaatcttcag 297601 taacaaatag caaaataagt gaacaaatgg cgaaaagctt ttatccgaat tcaaacaaga 297661 agcaaaatga agctacaaag gtggaaacta agccagcaac acaagcatcg tcttttcctg 297721 ttgttggtgg gtctccttct gttgctacta aaggaactac ctctttcaat gaagaaggaa 297781 atcgtaaaaa tgttaaaacg aaggccaaga atgagtctgc gcagattgat aggcagcaga 297841 aggaaacaac ttctagggtt gcagatttga aaagcgcaaa cataggaggt gaagacttga 297901 acaagaaagc agaggggtcc aaggaaccag aaaaagcatc tgccaatata caggatgcta 297961 acgataaaaa taactcgaag gaaaaagaag actccaaaag caaacaggta tctcagaaaa 298021 agttaaaaat gacagatcac ttaaaagaag gcaatgttca gcttcctaag cccagtgcaa 298081 atgataaatt gaaggatttg aaggctaaat ttactaatag taaaacactc gtgccacctg 298141 gaataatttc taatgaaaaa aataattcta gtgcaaacga tgatgattct agctcctcag 298201 gttcttccac agaagacgag tctagttcat cttcctcgtc ttctgatgag gaaacttcaa 298261 catccaggaa ggctagaaga gttgttgtaa atacaccaag agaaccagtt agatcttcat 298321 ctaagattga agccccctct ccatctgtta acaaaaaaat caatgccacc cctgataaaa 298381 ttccagttac acagctaatg gacatgtcgt ctcctccgtc agttaaatcc aagaccacct 298441 caaatccgtc tagtatactt catgaccttc caagaaaagt tcgtccttct ttgagttcat 298501 tatctgatct tgtttcaaga ggcatcccag atgtaaagga aaaaacttct aaatcgaatg 298561 agaagtcaca aacaaaagcc ccttcaagta gtgatgatga atctagctct gattctgact 298621 ctaactccag ttcggactcc gtatcggatt ccagttcaga ttctaaatct gagtcagatt 298681 ctgatgactc aggggattca tctgatgatg gaaaaagttt tattagtgcg aaatccgcta 298741 gtgctgcttt aggtaagaag aagaagccaa gtggtggatt tgcatcatta ataaaagatt 298801 tcaagaaaaa atgataccag aaagtctcag tagaatacac gtcacagaaa gctagtaaaa 298861 aaaaataatc aagcatataa aagtattaat atattaaaaa atcttcatgt aaaccaattc 298921 ttatttacct cttttcccag caagcgggca acttctttaa gaaaagtaat cttttttgta 298981 cgtcgaatta tcaaagcttg gttactatat ttaacattat tgtttagtaa cagtatcatc 299041 ttaaaagaaa attttttaaa attccaatat aggagacaat ggtaataatt acatacaaat 299101 agctatttat gtaagcaaaa ctgatatttt tatatacaaa tcgtttcaaa tatctcttag 299161 acttcagcga atttattgct acctctaatg aatccgattg cttcttctct attgacctca 299221 ataaccgtgg aaatcttatt ctcgtactta acacggaaaa atttgtctgc aacttgcaac 299281 atatctgttc tgaacgtcgt acaaataaac tgggcatttt ttgacagttc ttttagaagt 299341 gtagcgactg cagttctata ctgcttgtcg agtgcagcat caatttcatc aaacagatag 299401 aaggaagcag ggtcaaccat ttggattgcc agaatcaaag caatggcaca tacagtcttc 299461 tgaccacctg agagctgttc aacatgcagt tgttcgtttt gtttagaatt gaaggaaaca 299521 gaaattgaaa cacctgtata cataatttca ctatctttac cgttttggct ttcattggat 299581 tctgcatcca tgtcaacatc aatactttca tcatggtcgt tagcgttatc attcttacgg 299641 tgaataatca acttagcagt acctctggga actaatcttt caaaaacagc ttcaaagttt 299701 tcagaaacct tttggaaagt agaatcaacc gcgttaacct tttgttgttt taacttaaca 299761 attagatctt gaattgagtc tttagattca tccagctctg aagctctctc cgcaaggtct 299821 ttgcgtcttt cgttaaactt tttgaagttt tcaaaagctc tcttgtttac attcttcaaa 299881 ccagaaatct ctgtgttcat atcattcagt ctttgtaata gctgatcact tgtgatgtcg 299941 ctaaaatcat ttactaaagc atcctctggc agaagcccaa tttccctaat cctttgctgt 300001 aattcttctc ttctagtaac caaagttgtt ttcttaatca tcgttttttc aacacttttt 300061 tggaaattgt caagcttctt taatagtaat cgctgttgat tgtttgcttt ttctagcagt 300121 ttcttattat tagtttcttc agcaatgaga ctttcaattt ctctttgaac ggtacctagt 300181 tccaacacag cgttttcatg ctgcttttca acgctttcct tctccaattg taattctttc 300241 aactcatctt gtagaccaaa aataaatgcg tcacctactt ctgacatctt ggattctaga 300301 tcattttctt gtgggataag tttggactcc aattcggcat tcaacgagtc aatggttgta 300361 gttatacctt ctagggcgtc tgatgtaata tttagcttat tgtgcgctgc actaatctcc 300421 tttgttaaag attctaatct ttccttttct tcttttgaga gttcgctatc aaactcctga 300481 agcaaatcat tttcgaatgt atttagcttt tcctgagcaa atgtacgatt tgtattcagc 300541 ttttctagtt ttagtataat tgcgtttaat gattcttcga gaattaattt ttcattcttt 300601 ttggtgttta gcgatgttct atatacctcg atatttgtta agacagactc cctgtcatta 300661 gaaacctttc ttatattccc gtttacttga tcaatcttag tatcaatatc atttagttca 300721 tttcttacga aatctaattc ttccagtatt tttttgtgtt gacttcttga ttcatttaag 300781 tttttcaatg attccaaacg tgttcgtttg tgctggtcaa gatacccacc tgtaagtaca 300841 cctcttttgt ctgctctatc accatctaaa gtgatggcat tgagtttgtg tttcttagct 300901 aattttaaac cttgacctaa gtctttgaca acaatagttt ttccaaaaac gtgtttgaca 300961 gccttctcaa acctgggttc atattttatc ttctttatca agggagtaaa ctggatttgt 301021 gtagtagtgt ttgaggggaa tttaacatca ctgtccaaag ataacctgtt caagggaata 301081 aacgtcactc tcccaccctt catacgatat agttcgttca taatcaaagt ggccgtttct 301141 tcggtatcca cgacaatgtg gaagagggag ttacctccaa ttacttcagc acatgtcttg 301201 tacttatcat tgactttaat cagttcacct aatgtcccaa agacagattc cggtgatatt 301261 tttagttttt ctgtaatttc tttcacattt attataccat ttgccaatga tctactcatg 301321 gtttcattaa catttctttg attttgattg acgtcactta ataaagtttc caagactgtc 301381 tgtaattttt gctcctttct ccacaattcc ttacgagtgt ctaaactttc actcagcttc 301441 tgtttgaggt gtattaattc cgaatcaaaa tcttctaatt gacccttggt atctggtcca 301501 ttgatagaat caattagctc ttcaatctct tcatcaatcg cagagtactg cttccttaaa 301561 gaagtacgat ccatttgcaa ttgactttcc agttcattta agttttgtat tgaagatttc 301621 agttcttcaa tttctgaatg aatccacgta tcgcgttcat cctttgattt aaaacgggca 301681 tattctcctt tctttaagat aagatctctc tgcttttgtt gcaaggaggc caattgaagt 301741 ttgtacattg cttcttcctt tgtgagttct tgatatctag gtaaaatttt agacaacttt 301801 tgtttccttt gctcaattat agatttgatc tctttcaaag ttgcactatc caaatttctc 301861 tgctcctcat ttgactcaat ttgctgttga acatccttta tttttacgtt gacgtttgtt 301921 aatttctgag aaatctcaga ttcccgtagt tttgcctgtt gtaaatcagt cgcatttttg 301981 atcttcagtg aagcttcaat acttgatagc tttttggaga cttggtcaat catatcctct 302041 cttttatcca actcctggat gtattgttcg gaagagtata ccgtgttatt ataatcaccg 302101 tccagtcttt ccatttgatt gataacctca tttaattctc gatcatacaa tgtgaactgg 302161 tagatctttc tgttgcgttc caactcgttg tatttctcta attccttacg ttcctgttcc 302221 atttcactca atttagagtt tagttcaccc atttccttgt taatttgaat ctttttctgc 302281 tctgtttcct ccattttttt caatgaagct ttcaatttta cttcaaatga cttagctcct 302341 acaacatctt ccaataactg caatctttcc ttatccttgg cattagttaa ggcgactatt 302401 ttaccttgtg gtactatatt atacggatta ttcattgaaa aaccagcggt ttccaacatt 302461 ctgactatgt cccctttggt cacgtttctg tcatttaatt gatagtcatc cttcttcagc 302521 cctactgttc ttctaatggt cacttcgtca tctcctctcg aaagtacacc ggagggcaat 302581 atcatagaat gatctggatc gtggaacaca atttctaccg aggcactcat cactgaacca 302641 ccagaacctt ggtggataag cccttgcctt tcttccctct taagattaga gtaatcgtca 302701 ctaagaacaa atctaatcgc agcgaagaaa ttcgatttac ctgaaccatt ggagccaata 302761 ataacattct gatgcggcga gaaattatca ataatggttt cgttcctgta ggttttaaaa 302821 cccttaatta tcaccctttt gatatacatt gcagacgtga actattaccg ttactccagc 302881 aggtcgtctt gtaaaaaaat ggtgaaactg tttaaagatg aggttgaaaa ctcatcttta 302941 attagtttaa tcatttccta acgcgtcgcg tcttttccta ttcctgagac tttttttctt 303001 taggttccta atagtgaaat gtgacaggtg tacacttcga tggcaggcaa aaatagagcc 303061 aaaactgctt ataagttatt ccaagtgaaa ggagttggtt gcgagaaggg cccagaaggt 303121 ttcattcatt gttggtttag tgtattacta aggccgatct taacgtctac gaaacgaagt 303181 atgatactga tctcgggata ctgtctttta gtgtatagcg ttattttgcc agtactgata 303241 tcggcttcta agttatgtga tttggctgag ttacaacgat tgaacaagaa tttaaaagta 303301 gacactgaat ccttgccaaa ataccaatgg atcgctgggc agttggaaca aaactgcatg 303361 actgcggatc cagcaagtga aaatatgtca gacgtaattc aactagccaa tcaaatatac 303421 tacaaaattg ggctgatcca attatccaac gatcaacatc taagagctat taacacattt 303481 gaaaaaatcg tttttaatga aacttacaaa ggttcttttg ggaagctggc ggaaaagagg 303541 ctacaagagc tgtatgtcga ttttgggatg tgggacaagg tgcatcagaa ggatgatcag 303601 tatgcgaaat atctgtcctt gaatgaaacc atcagaaaca aaatatcatc caaagacgtt 303661 tctgtggagg aagatatttc tgagctgcta cgcataacgc cgtacgatgt taacgtcctc 303721 tccacgcaca tcgatgttct ttttcacaaa ctagctgaag aaattgacgt ttcgttagct 303781 gctgctatca ttttggatta cgaaacaatc ctcgacaagc atttggctag cttaagcata 303841 gatacaagac tttcgattca ttatgtcata tctgttttac agacctttgt acttaactca 303901 gatgcgtcgt tcaatataag aaaatgcctt tccattgata tggactatga taaatgtaaa 303961 aaactaagcc tgactatttc caaattgaac aaggtgaatc catcaaaaag acagatcctg 304021 gatccagcaa catatgcatt tgagaacaaa aagtttagaa gttgggatag aattattgaa 304081 ttttatttga aggataagaa gccatttatt acaccaatga aaattcttaa caaagataca 304141 aactttaaaa acaactactt ctttttagag gaaattatca aacaattgat agaagacgtt 304201 caactgtcga gacctttggc aaaaaattta ttcgaagatc ccccaataac cgatggtttt 304261 gtcaaaccaa aatcatacta tcataccgat tatctagtat acattgattc cattctttgt 304321 caggcttcta gcatgagtcc ggacgtcaag agagctaaac tggctgcgcc gttctgtaaa 304381 aagagtttga ggcattcact aacactagaa acatggaaac actatcagga tgctaagtcc 304441 gagcaaaaac ctttacctga gacggtattg agtgatgtat ggaattccaa tcctcatttg 304501 ctgatgtata tggtaaactc aatacttaat aaaagtaggt ctaaacctca ttcacagttc 304561 aaaaagcaat tatatgacca gataaacaaa tttttccaag ataacggcct ctcagagtcg 304621 accaatccat acgtgatgaa gaacttccga ttattacaga aacaattaca aacctataaa 304681 gagcataaac atcggaattt caaccagcaa tatttccaac aacaacaaca gcagcaacaa 304741 caccaacgac atcaagcacc cccagcagcg cctaactacg acccaaaaaa ggactattat 304801 aaaattcttg gagtatcgcc tagtgctagt tcgaaagaaa taaggaaagc atatttaaat 304861 ttaaccaaaa aataccaccc agacaaaata aaggccaacc ataacgacaa acaagaatca 304921 attcacgaaa ctatgtcaca aatcaatgaa gcgtacgaaa cattaagtga tgacgataaa 304981 aggaaggaat acgatctttc cagatcaaac ccccgccgca acacttttcc tcaggggcct 305041 aggcaaaata acatgttcaa aaatccagga agtggcttcc cattcggaaa tggctttaaa 305101 atgaattttg ggctttgatg aaatacattc tatgcccatt aactaggata ccacaacaag 305161 tacatatata tacatacgca tatcactgaa agttctaatt attgcaaagc cagcactttt 305221 ttaaatattg aattcttctt catcattttc agtaccagcg gtaagagatg ctgtgtgaat 305281 ttctcgcagt ttatccatga tttcagtaat gaacggcctc aactcattga tttctaatag 305341 acttaaatta tccaattgta aatgagattc attcaaatac ttaaggcctt ttaacacttt 305401 gatctgcctt atttccctta agtcttgtat tttaccacgt aattcgtgaa tggggtcatg 305461 aaaatcatcc ttagctttat tgaaaagtat acgtgccaag acaagccagt tccacggcaa 305521 ctcactaaac ctatccggat gagttttctc atattgtatt tttctatcaa gctctttcgt 305581 cgttaaccac tgtggtgcta caatactgca cttggattgt tgcttcagta atagagcgat 305641 ccaaagaacc acttctgtag aacgcatggc taccatatta tttaaagctt tgtcatctgt 305701 agtaataagt tgccagcggg tgtggtttcc agttcctcta tcatcgccac gaattttttg 305761 gcgtgttgtt attctgggaa aaatctttat tggctcgttt tccacaatga actgtatttc 305821 ttctggtgag aaagtctgct gcaaatgtgc cggtagtgac atgcgtctat gaaactagtc 305881 ttatttcaga tcagccgttg atcctctcta agtataaaac tcttttttgt taaccatttc 305941 atagttacac tttaggcgac tgatttttca ttaaatggaa aatatcacaa gaaatttcac 306001 gctggagaaa aaaaaggtta gtcatcactg atcttcccat ggagtcataa gcacgttcga 306061 cataaattgt gaaagttaac acatttgaag ctaggaccgt caatctagga cactagtcgg 306121 ttacttttat catgtggagg agaatattcg cgcatgaact caagtatgat caacccaatg 306181 catcttcaaa aaacttgatc ctttcagttc tgaatacaac cgctacaaaa cgagaggcta 306241 aggattatct ctcaaaatat acaaatgata gtgggcagca taatcattgt ttgtttttta 306301 tcagggacct gcataaagtc gcaccagcga ttttgtccca gttttcaagt gtcataaaga 306361 gactaggaat gctaggtttg cgacctatgt ttgtaattcc gccgtcgcca actcatgtaa 306421 atatacaggc agagttactt gacagtatcg ttacagaagc agatttaaag ccacttcacc 306481 ttaaggaggg tcttactaaa tcccgcactg ggttatatca ttctgttttt tcgcaagaga 306541 gtcgtttctt tgatattgga aattccaatt ttataccaat tgtgaaacct tatgtgtata 306601 atgaagagac tgcttcagaa ttcatgacaa aggatgttgt aaaatttatg gattgcctgt 306661 gccaagggaa tattccacac attgacaaat tcttcattct aaataatgcc ggaggtatac 306721 cttcgggaga gagaaatgat aacgctcatg tattcatcaa tctttctcag gaactcgagc 306781 atttgtcctc gtcattatct cacaatataa gcactctaac caaacgagag ccacgctccc 306841 aaaacctgtt acacagaatg gaggtgtacg ttaaaaaaga tgagatatct tccttagaat 306901 gtgaatacca tgatcattta gaaaacctgt tattgatgga caaagtttta tcaaatctag 306961 cggctacagc aacgggactg attacaactg tcaaagctgc cgcactatca tcagatagga 307021 aaaatccttt agtatataat ttattgacag accgatcgct aatttcttct tctttaccaa 307081 ggtttaaaaa aaaggacggc gagatagact caccagccaa catgtttgat gatcacgcat 307141 ggtatgaatt gccttcccaa caggtaaatg cagctccttc taactcagat gcagttttag 307201 tgacaactgt tctcaaaaag ggcgtccata tcaaaactta tgactataag acgctgactc 307261 aattcaactc aattgggctt ccaaagaagt ttcacgtacc tgagaaagga gcaaaaccct 307321 cgagcaatag tccaaaacta gatatcaaca aatttaaatc catcatcgat cagagcttta 307381 aaagatcttt ggatttgcat gactacataa aaaggattaa tggaaaaata gctacaatta 307441 ttgtgatagg tgattatgaa ggcattgcaa ttcttaccta tgaaggctcg gaggaaaatt 307501 cctttgttta tctcgataag ttcgccgttc taccacactt gaaaggctcg ctgggtatat 307561 ctgatataat cttcaatttg atgttcaaaa aatttcctaa tgagatactt tggagaagca 307621 gaaaagacaa tgtggtgaac aagtggtatt ttcaacgtag cgttgctgtg ctagatttgt 307681 cgattgactt agaccccgaa cactgtgatg aaaagcaaag ccaatttaaa ctattttact 307741 acggtaaccc tcaatacgct aagagggcac tacgtgacaa gaaacgttta agagaattca 307801 tgaggtctgt cagggacatc aagccaagtt gggaaaatga aaaaaatatt tcatgaaaca 307861 aagacgcatt ctcctcctcc ttaactttca agttttcatt ttcagttttt aaggtatcta 307921 tataaatata tatatcttac tatgcaaagt tgttgatatt tcactttacc ctaccaaatg 307981 gagttaatta ctccaaagtg atcccgaacg aagttccact cttgatccaa tgtctccttt 308041 ctatatcttc ttctaatcat cggaacgttg tgctttatcg aggtatcttt cgctgtatcg 308101 taccaattat ctatcccacc cacgttctcc tcaaagtaag gcgccttttt aactccaacg 308161 ccaatccaat gagccttgta ccaaccttca tagccactag atagcacact tgttctcgac 308221 aactcgcaca aatctgttgg gttcagcaag taaatacttg ctgctacact gtattcttca 308281 atgagaggtt ctagcgtgta tgaactattg taaagaatcg attttgatga taaagaaatt 308341 tttagtccca tcttaaacat tttcatgaaa ggatttgtct catatgatct ttgttcgccc 308401 acagtgatat ctctagaagg attgattttg gctgtttcct ggtctttcaa ataatcatgt 308461 tctagaagca cgtttttatt cttcaaaaag gtcgattttt gcgaattcag taatgaaaca 308521 gatgataatg gcgcagctaa aatgggtatt tgaaagagat aaaataaata ttgaatcatt 308581 gttgcagtat cccaaagcgg ttctacctgt agcagaccac cattacaaag cagtaagttg 308641 cacactaacg attcaacttg atctgtaaaa tataaatcca ctccaaattg ggaagttctg 308701 ctggatagtg gagaacaata atttcttagg gtgattgtat tttgaagatt ttgtgaccgc 308761 agaaaattaa ctttcgctaa acttttataa atataataca tgtaatgcgc aacagttgga 308821 ttgtcaccct gtgctgtcca aaattttggc ttacaattca tatcagtaaa ttctttccag 308881 taatattcat ccgactcttt aatgaccaga tccatagaac acacatttga taaaaaaaac 308941 tgcagaccaa tgatatcagt atttacagat gaatctattg gtaactgctc cttttccaga 309001 gtgaataaag gattgaagat aagatccaaa aactcctgga aatttgacac gacattttcc 309061 ttgaatagtt tgggaaaaat cctggcaatt tgtatattcc agcggatatt atacgatact 309121 agcttccatc gtagcaacca ttgagaaaat ttcttgtacc agtcttcacc actggaatag 309181 aattgaaaat taactgatac ttgggccaat tggtactttg atttttcgag gatatgaata 309241 acgtatttta tgaaaatttc tgctaggtac tcaccttcaa tgaaattatc aaactccaga 309301 aacactttgg ctaataggta aaacctcatt tctttgccga ccaactttgc tactttgtta 309361 ggagttagat ggtaatctat taggtaaata tttctatacc aatccaagaa ttcatcatca 309421 atcaatttca acccaatcgc aatgggttgg tcattagaag aacaaccaaa ctgaaaaatg 309481 tctctcaaac tgagtttcct tgacgtttcc gggtcttgat aaactatcct ttcaggttct 309541 aaatttattt tctcccatat atattcactc aattgacgtt gagaaataca accacttaaa 309601 gacaagtctc gatctacctt acgagaatta taaaaatctc tgtagggaac atttttatta 309661 gctaaaattt ctttcttaga gtttaggtac tgaaacaatt caaatttatc taataaataa 309721 gataatcgct ttcgtgaaac ctcgttgaat ttatgagatt ggattaactc tattatgtat 309781 gcaaaatcat ccctaaattc ttgaaacgta ggcacatctg ttaaaaattc ttcctctagt 309841 gactcctcct tactagaata aggtgaaagt gggttttgcg tattttcctg attacttaaa 309901 tggtaaatgt attgtttttt gtaatcctct aaatcgaaat attcaccggt gtatggtact 309961 tttatatttc cttttccttt caaaccagat tttgtgtagt agtagtagtg atcggtaaag 310021 taacttgggt aatagtagcc atggcggtgc ggtgtagcgg ctccggtccc agtactgtct 310081 ccatcgtcat ttaagtcaga gtcagaggga tcttggaatc gtttatcgtc ttcaaatctc 310141 caaaactttg gcagtggttt tgggtataaa aaccactttt cagtgtcatt ttttatgttt 310201 gaaatgccat cttgtttgga agcagcaatg tatctttttc tcatttgaga aaccaattca 310261 aacggattaa tgaaaagatc tttagtttct tcacccgttt tcagatttga gggcgtgtac 310321 gatgagacaa agctgtcact ttctccattt ccataatgat gggaaactga aggaagtgga 310381 tcaattttgt tttcttcgtc ttcaagatcg aaaaacatag gtgaacctaa aaccatttgc 310441 ctgtcaaatt ccgtgggcaa agaaatcata tccatatcat cgactgatat ttccttctgt 310501 ttcaaaacag atggggagac atcaccgtca ttctctgaca agaccctggc ttctttattc 310561 ttcgtctcat taggcttagt aacagaattt tgatattcgt caaagagtaa cgagggcctt 310621 ctctctaccg cctgcataat tcccagcgag atgaataagt aaagtgagat ttagataact 310681 cttacagagg atattgagag gacattttaa tcaaattctt taaactcaat gtcccctttt 310741 tttccatata ttatatttaa tttctcggac aatttttcat ttctgactat aaatgacagc 310801 aagaaaaaag tgggcagaat catattcaat ttcaagtttc ttcgcaattt ttttacagtg 310861 atattttgtg tatgtatttg tacattgctt ttaatatcta agtttgtcta taaatggaaa 310921 tttagtagtg gtttaatttc cagagcctca ctttaccttg ttcgttaccc acggccagta 310981 gcccaccaga tggcgaaaat gcgacactgg taactttacc caaaggcgtc ccgctggtag 311041 gccagttgct gaacacgcta caagaaggca gatgaactag tctcaaagca tccttgactg 311101 cacgggatgc catgcacagt atttgaccat caggggaaaa ttgtagatta gaaatggtag 311161 ttgttagctg gtccaaggcg gcgacaggtg taggggtcga cgaggtcata gcattatttc 311221 tatcgtaaag attaacaaat ccactctcac tacctaccgc aagccaccta ttttgcttta 311281 tcttacttat ttgaagagcc ggacaagtag ttgttgtccc accaccaact tggatttttg 311341 ttatacccac gccaccttgg tctttccatc ttcttataac atggccattc ttattcaagt 311401 caaattccca cacttcacca tacgcgttta cagcaattaa aatggtccta aacttaccac 311461 gtgaaatagg ttgataatcg atacagaaat ccgttatcac accttctatc ttgcagccca 311521 ttaaccatag tccggaagtg gaatgtaaaa tgttaatcca accattatta ccctgtaaaa 311581 ggacaattcc atggacagaa tttgtttgtg aattctgcaa atgtgcaact ttgaaattct 311641 caaatgatct ttgagtggac tcatgtccat acaatctgga aaatttttcg attttggcag 311701 tctgtgaatg agttaaattt tctaaggata agtcccagga atgcatatat cttcttctac 311761 cggcggtgaa tatattttgt tgattttggt ttgatagaga agtatagaaa gtacatgttt 311821 gtattggaga cccaaccagg tgcaaacttg tcactagatg gttcgttttc ccgtcaatat 311881 gatatattct taaggtctta tcatacccac ccgttaacag tagaggctta gaaggatgga 311941 atgaaagaga ttgtatggcg gaatgagacg ggtgtgatgc atttgcatct ttaagacgca 312001 caatgtcaag tttcttaggg ggtaatagtt tggaattcga taaagtgtct ttataattgt 312061 aagtagtaga caggatcttc gttagagcat taatatctcc attaataaca ttattagagc 312121 cttcttcttc atcgtcttct tcgtcatcta attcagaatc agattcatcg tccacccatt 312181 tgggccttgg atatatcttt tcaaactgag atctcaatct gttgatgtaa tgaacaccgt 312241 tgattttgga ctcgttatag gaggttctta atttctttgt cttattggta acaagaatag 312301 gcactttaat tttttcatca tccgaatcta tccaagcagc ttcttcagag tcctcagaat 312361 aatcatcgct tgaagagtca tcttcgtcat ccacgtccat ggtatcttca ttcttatctt 312421 gactatcttc gttaccacca tcgtccacaa aaaataactg atcgttgtta acatggtcta 312481 attcaccgtt ctgcgcttca tcttcttcac tgttatctga ttcagatccc tcatcctcct 312541 ggtcttcaac atccatttct tgttcattga aaatgaaatc ggcattaaat ttagcgagat 312601 tttcttgtaa atctgttgta tcaccgaata caaatttggc tagtaactgt tcttcttcat 312661 ctggtggagg tacgctaaca ttcattgcgg ttgttgccat tgtcattgtc gcactaatgt 312721 aggctgatat acactttcaa gaacgatacc acaacaggac cagagtgatc gatgagatga 312781 ggtgaaattt ttttattttt cgtttttttc atttcatatt attaaattcg tcggatgtga 312841 tgccaattaa ccacataata gcaatagtaa tggaagttac aggtgacata aaatctactg 312901 cgaataacct ttgaaaggat aactatgttt ggccattttt ttctacggac gtatatttca 312961 ctaaatatgt acatagaaaa gtcataaaaa ttaccataat gaaatgcgat gcctctcaaa 313021 tcaaacccaa gtttcgcgca tgaaattcag catgttctgg aacgaaagtg ctgacaaagt 313081 aataggagtg atcaaagccg tgaacttttt ttatttccac gtagtcctgc catgaagtgg 313141 ctttcaccgc ctcaagtagt aattccggtt tcaagtgttc ttccaaaaag ggatcggagt 313201 ctcctacatg gatcaaaatt ctgtcgtcgc ccacatgtct aatattcttg attaataaac 313261 atgggtcgta cgcttcccac tgggcttttt cttcgcccag ataaccttta aacgcttttt 313321 gaccccaggg aacgttggaa gggttcacga taggggcgaa ggcagaacaa gatttgtatc 313381 tctttccgga atagcccttc aaatacccac aaattgcacc atatcccccc atcgaatggc 313441 ctgtgatggc aacattgtcc aagaagtcca gctttacgtc accgttcttg ttaaaatgag 313501 aatctaatgt ttgtgggagt tctttgtgaa tgtagtcgta catctggtaa tgttgggcgt 313561 atggttcttg ggtggcattt agatagaatc cggcgccctg tccaaaatcc caggagccct 313621 caggatcatt ggctacttcg tcaccacgtg gggacgtatc cggaaagact attgcaaatc 313681 cgtacttgtc agcttgaaac tgccaaaaag ccttctcaga ggcgttgtct ggcgtgcacg 313741 tcaagccaga aaggtaaaac acagttggga tacgcttatt tcttggaaaa tcttgggcgt 313801 aatagtgctt aggcaaatag atattgacgt tcatgctggt cttggtagag ttcgagttat 313861 gtgacaactt gatcaatctg ccaccacaga cactaaattc cttaacaacc ttcatattga 313921 actatgtgaa tcgcttatat gtattttatt gatgctatat attgtcaaaa atgtgtattg 313981 atcttttgtg tgtgtgtgtg tggatctccc cttagcagtc gcatgttttc cacacgcgca 314041 aggtcataat cgtgcgatat atacaaggca tattgtgtaa gatatgagta aaaaaaggaa 314101 acgaaaatat gtcctaattg tcttcgtcaa cactcaccac tttatgcttc acctggggac 314161 tggaaccctt ggaggtagtg gtggtagtaa tgtctaccgt gccatcgtca aagtagattt 314221 tttcagtttt gacggtgctg ggttttgcat cattggaatc cttcgtggta ctaatggact 314281 gtgcccttcc aacaattttc ttggatccat ctgcagaagc atattcagca tcgttgccca 314341 gatgcaagtc gtcccaattc aacatgaggt cttctggagt tctagccaga ggctctacgg 314401 cagtgctcct agtcttgatt ctttgttttt gtagtctatt catgtgcgac ctccacttca 314461 aaaagaggtt gaaatcattg aagaacaacc catgagagtg cgacttgtca gatttgatct 314521 cctccagagg taagaggaag tccaattgtg gtagaggggg gatagcctta cttgggacaa 314581 gacatttcca aatcccttgg gtggtccatg cagactggcc cttaagttct tcgcacttgt 314641 caaactgctt caccgtaggg attccggacg ccatggcaag tgcactatct ccaagatctc 314701 tgaagttgaa attgaagggc agtggtagga gtggattatc gtattcatca atatccctta 314761 actttggaaa gaggttccag aagggtgccg ttgcgaactt ttgatctttg atatatttgt 314821 cattaaatgc cttggtgttg gcatcattgt catcgccttc ataaaagccc atatcgagta 314881 aacggtttgt cggtttcctt tgtctttctt gtccttttcg tttgtaacct cctaaattca 314941 aggcttaata tttttttttt cccctttact taattaacgt ataaagaaac tatgttgttc 315001 tacagatcgt gagagagaga agaaaaatcc ttctatgcaa tgtgcttgtg tagttattct 315061 tgatcagtaa cgtcttcgtc gtcgtcttcg tcattatcaa gatcaatctc gacaatgttg 315121 ggcttcggag ccgtatcgtt caccacatag gcggagtaaa cttcattagg gggcatgaca 315181 cttgtagtat atctaactcg gttttcttcc actagaagcc tcaaattctt tgttgttggt 315241 atcacatcat tcaaaaactg cagatggccg tcagaagagt gcacaattgc ggcagagatg 315301 tcatcgtacg acagcgtgag ttcatctggg agcggcggta cctgttgttg ttgctgctgc 315361 tgttgcctat gtagggactc atgtgtcagc acctggacga agaattctgt agcaaacgct 315421 gtggctacga atgcgtcatc cgaagtgtcc atatattctg gatcattctt ggctattctc 315481 tgcacttttt ctacaggtaa cttgggcgaa cacagaggtg cagacgccgt ttctttacca 315541 ctagtctcgt tgttcattgt gttagcctga tcacatcgag cgagctatcc tgacgctatt 315601 ctctcttgtt tcttctgttt tgtttctctt acatttttca tttttttctc tagttggaaa 315661 aaaaaaaaaa cactatatta gaatacgcac attgttagcg ctgttctttc aattgtcatc 315721 tatatattta caagggaata cacaaaatcc tggttttttt aaggtctggg aaccatgaca 315781 taggaggagg gtttcttcgt cttctttggc aatgacgaag agtagacctc cttcaaaagt 315841 gcctgcgtcc tttcgttttc gagtgcctca tcatagggaa gggacatttc cttgagtaag 315901 acctgcttga tgagcataat ttcaccatgt agctgcgctt ctgctttaaa cttggccact 315961 ttgtgaagat tctgcaatgt gagtgggtta tgaggtagct ggttggcgtc atcgttgatg 316021 actgacttga ctaacagcca catctttaaa ttgcccctgt tcaccgtatg cgattcggac 316081 atcacgggag agtcgactag ttccaagacg gattgcggcg ctgagtcgtt agccctaggc 316141 tctaaccgca gcacacgcgt gtacccaccg ggcctttcca agtaccgcgg tgcgatctcg 316201 ctgaacaacc gcttcatcaa ctttctgttg tctcctgcta aaaacaattg gctctgaatt 316261 tgggacttta attccgcctg tgcaacacta ttacttgtcg ttattgccct ctttgtccag 316321 gtaatgatcc gctctgcgac cctggaagcc tctttacatt tggcatgcgt tgacactata 316381 gattcatgct gaaacaactg gcacgcaagg ttttttagca gcgcatccct atgcgccttg 316441 tccctagaga gtttcctagc aatacccact gtcattgttg cgctcgactg tgcttctcac 316501 cgttttttct ccttggcgta gccaaatctc ttgaccgtta taagctgttt tagcttgtca 316561 aatcccactt gttcttgtta accaactttt cccgcctcgt acgcggtgac agacaaagca 316621 gtgatttttg ctcattgtat aaagggagtc tttactatgg tggcataagc aacaatacta 316681 cgtgagcagc aacgaaagca catatataga cgacaaagta gtatggtttt gaatccgtcc 316741 aagtaccaag acacccgcac gtggaagatg acgcctgcca tgatcagggc ccgtaaaccc 316801 tttttcaaag gcaatatgct cggtctcacg ctgctgctgg gtgtcacggg ctctgtttac 316861 tactacacat atcattttct gcacaaggac aacgactttg cagacgtgcc cattccaccc 316921 atcgatccgc aggagctcga ggctctcaaa aaggagtacg aagccaagaa gaaggcatga 316981 aaagaccgtt aatgtggagg tacgctgtgg tcttccatca ataggctttg cgctgttctt 317041 ctctcctctt ttgtaaatag tttacctact tgcgtatatg tatatatata tatatataga 317101 tatgcttata cggatatata catacattct gtttgtttat actctttgtc ctactctaac 317161 agccagctct ttagtttaag aatatgatga aaaactcagt ttgggaaaaa aaaggaaaat 317221 gttaaagtat aaacaatatc gaaataagtt catctaccac gcacacttca ccaagttagc 317281 aagatgaact tgaagcagtt cacgtgccta tcatgcgctc aattactcgc tattctgctc 317341 tttatctttg cttttttccc tagaaaaatc gtgctgacag gtatatcaaa gcaagatccg 317401 gatcaagacc gtgatctcca gcgcgatagg cccttccaga aattggtgtt tgtgatcatt 317461 gatgctctca gatcagactt tctttttgat tcgcagattt cccacttcaa caacgtgcac 317521 caatggctca atacgggcga agcatggggt tacacgtcat ttgctaatcc gcctaccgtg 317581 acgctgccta gactcaaaag tattactacg ggatctacac ctagcttcat tgacttgctg 317641 ctgaatgtag cccaggacat agattccaac gatctttcgg agcacgattc ctggctgcag 317701 cagttcatcc aacataataa cacgattcgt ttcatgggcg atgacacctg gctgaaactg 317761 ttcccacagc aatggtttga cttcgctgac ccgacacact cgttctttgt cagtgatttc 317821 actcaagtcg ataataatgt gacgaggaac ttgcccggga aattatttca ggaatgggcc 317881 cagtgggacg tggctatcct gcattacttg ggtcttgacc atatcgggca taaagatggc 317941 ccgcattcaa agtttatggc tgctaaacat caagaaatgg acagcattct gaagtcaata 318001 tatgatgaag tgttggaaca tgaagatgac gatgatacac tgatttgtgt tcttggcgac 318061 catggaatga acgaactggg caaccatggt ggctcttcag ccggcgaaac atcagcagga 318121 ttgttgtttt tgtcacctaa gctggcgcaa tttgctaggc cagaatcgca agtaaactac 318181 acattgccca tcaacgctag tccggactgg aatttccagt atttagagac tgttcaacaa 318241 attgatatcg tccccaccat agcagcactg tttggtatgc caatccccat gaacagtgtt 318301 gggataataa tacctgactt tttacaactg ttgcccaata agttggcaag tatgaaagaa 318361 aattttatgc atttgtggaa attatcagac catcacggcg aggttgctct tgacgatttc 318421 actgccgaag atatttatac aaagatgtac actattcaag aaacgttaac caagtctgca 318481 acaaattata attatcctct tttgacactg gcttttgttg gtttcctcat aataacaatc 318541 atcgccattt atgtattatt acgttattct gggcctgatt tttggcagtt gcgcgtttct 318601 tccctgtctg ttctgttagt ttccattata ctaggcgttt ccacatttgc aagtagtttc 318661 attgaagagg agcaccaact gtggtggtgg atagtaactg cattctcggc ggtccctctg 318721 ttcgtatacc gattgaatgt gctcataatc gtgcgctggt ttataatgat ggcatgcgta 318781 cgctcaatca agttttggaa taacagtggc cagaaattca tttattctaa cgttatgtcc 318841 aatctactta atcagaatcc ttcctggaag tggtgcttaa atatgttgac atttctagtg 318901 ctgataatgg catctgctgg ttttcaagta ctacatttta ttgtcactac tattttggtg 318961 gggttgtgtt tcacgtacaa aatctcgtgg gaaatcgtca atggtaacca ggcagaaata 319021 ccgctcttta tgcatgattt actggctaag atagactttg caccaactga aagtaacttg 319081 attgtacttg cgcgcgtttt cttccaagct tgggctattg ttgtcatttc aaggttggtc 319141 ctgacgaaat tgaaagtact taacaagaac tacctcatta aagatatgaa agtttatata 319201 acaattcttt tgatgttcca aacttcttct cagaacatag gtcaatttct cgttttccaa 319261 atattagagt cccaaatttt ttactttttc caaaatattc caaccgcctc attaacatca 319321 acaagtaaga tttatttttc gaatttggtg tccttaattt tacaaaattt tacatttttc 319381 caattcggtg gcacaaattc catttctact atagaccttg gaaacgcata ccatggtgtt 319441 tcctcagact acaacatcta cgtagtgggg atattaatgt ccgttgccaa tttcgcgccg 319501 gcaatatact ggtccatgct accgtggtca ataaactacg cctctattcc agcacaagtt 319561 aagttgcaaa cgttcatcag aagtaagtta cctgccttca cctatcattg tatatttgga 319621 acttgtttga tgacggcatg cgtcgttttg agatttcatc tctttatttg gtccgttttc 319681 agtccaaaat tatgttattt tcttgggtgg aattttgtga tgggattgct gaatggctgg 319741 ttacctgaat tggccctcct ttgcgctctt gattaacata gaattgttca cgtggtctaa 319801 atatgtatac atatatgata gtttatagat tcatactgag acaagtgaaa aaaaaaaaat 319861 ctactatcga ccttctctct tttcgcggca gcaaaaatga aaaattaact tcaataaaaa 319921 agttgaatac tttcaaatat tctaattgca tttaatattt aagcaacaaa aggacagcga 319981 taattgagtg gtggcttaat tctatactcc aaagtatgtc ccaatctagt aggttaagtg 320041 cacttcctat tttccaagca tcgctttcgg caagccaatc tccacgttac atttttagtt 320101 ctcagaatgg cacaaggatt gttttcattc aagataacat aataaggtgg tacaatgtac 320161 tcactgattc actttaccac agtttgaact ttagtcgtca tctcgtcttg gatgatacct 320221 tccatgtaat atctagtacg tctggtgacc tactctgtct tttcaatgac aacgagattt 320281 ttgtaatgga agttccttgg ggctattcca acgttgaaga cgtttccatt caagatgcat 320341 tccaaatttt ccactattca attgatgaag aagaagttgg tccgaaatcg tccattaaga 320401 aagttttgtt tcatccaaag agttatcgtg attcttgtat agtggttttg aaagaggatg 320461 acactatcac gatgtttgac atccttaatt cgcaagaaaa gcctatcgtt ttgaacaaac 320521 cgaacaactc ctttggttta gatgcacgtg ttaacgacat cacagattta gaattcagta 320581 aggacggatt gacgttatat tgtctaaaca ccacagaagg cggtgatatc tttgcatttt 320641 atccattttt accgtcagta ttactgttaa atgagaaaga tctcaacttg atcctaaaca 320701 aatctttagt aatgtacgag tccctggatt ctacaacaga tgttatagtt aaaaggaatg 320761 ttattaagca gttacagttt gtgtcaaaac tgcatgaaaa ttggaattca agatttggca 320821 aagtcgacat acaaaaggaa tatcgtttag ccaaggttca aggaccattc acgataaacc 320881 cctttcccgg cgagctgtat gactatactg ctacaaatat tgcaaccata ctaattgata 320941 atgggcaaaa tgaaattgtt tgtgtcagtt ttgatgatgg gtctttaatc ttactcttca 321001 aagatttgga aatgtcaatg tcgtgggatg ttgacaatta cgtgtataat aattctttgg 321061 ttctaattga acgagtcaaa ctacaaagag aaattaagtc tctaataacg ttacctgaac 321121 agttgggaaa actttatgtc atttccgata atattataca acaagtaaat tttatgagct 321181 gggcttctac attgagtaaa tgtatcaacg aatcggattt gaatccactt gcaggattga 321241 aatttgaaag taaacttgag gatattgcca ccatagaaag aattccaaac ctagcgtata 321301 tcaactggaa tgaccaatct aatttagcct tgatgtcgaa taaaacattg acttttcaaa 321361 atatttcaag cgatatgaaa ccgcaaagca ccgcagctga aacaagtatc agtacagaaa 321421 aaagtgacac ggtaggagat ggttttaaaa tgagtttcac acagcccata aatgagattc 321481 ttattttgaa cgataatttt caaaaagcct gtattagtcc atgtgaacga attatcccat 321541 cagcagaccg ccagatacct ttaaaaaacg aagctagtga aaatcagttg gaaattttca 321601 cggatatttc caaagaattt ttgcaaagaa ttgttaaagc tcaaactttg ggtgtttcta 321661 tccacaatag aattcatgag caacagttcg aattgacgcg ccaactacaa tcgacatgca 321721 aaataatttc aaaggatgat gatttaagga gaaaattcga agcacaaaat aagaaatggg 321781 atgcacaact aagcagacag tcagaattaa tggagagatt tagtaaattg agcaagaagc 321841 tatctcaaat cgccgaatcc aataaattta aagaaaagaa aataagccat ggtgagatga 321901 aatggttcaa agagatacga aaccaaatat tgcaattcaa cagctttgtt cactctcaaa 321961 aatcccttca acaagattta tcgtacttga agagtgaact aactcgtatc gaggcagaaa 322021 ctatcaaagt cgataaaaag agccaaaacg aatgggatga gctacgcaaa atgcttgaaa 322081 tagattcaaa gataattaaa gaatgcaatg aagaattgtt acaagtttct caggaattta 322141 ctactaaaac tcaatgagta agcgacttgc atagtctgct atcatatatg tacgctaaga 322201 aacaactggg caatggtata atatcatgta gcaagaggac attatatatg aattggtcaa 322261 tatataaagc cttctgtgca ccaaatcgtt aggatgattt ttcagtatgc tgtatcattg 322321 tatcgtatat tcattcgtat ctcttttacc tcactaaccg ctgccaaaat ttacatgtat 322381 acaaaataaa agtctttttt atgaccttat ttggtgagta atgctacttt tgtaaagagt 322441 gatggaaact attattccaa agggttagaa gaaggtgagg aatacgttca tatcaccgct 322501 acagatcgtg tctctcggtt atgagtaatc aaaccctctg caagcaacac agttactttt 322561 tttcggtttt ttcttttcgt gtgaattttt atccagtgag tttccttgtt cactttcgag 322621 aatggaaggc tgatttcgaa tttttatatt caacaactgt atttgtatta ggctttgcaa 322681 tagtagatga aaagtgcaga agacgaatct gctaccctca caatacaaag aaaaacaaaa 322741 tcgtcatttt aatataggaa gacaccgctc aggtaattca atattgaatc tggttgcact 322801 tttcttacga tgtaaatacc cacaaacttc ttgtacggtg agcgtctgac aacgaaatca 322861 atttacggag caaggatttt gacagtagag cagattgttt tgagtaggat ttaggaatca 322921 agacctccat ctttgtcgca ttattcctaa atgtaacgta actcgtttga taagagaatg 322981 tctaatcgaa gagagttaat aacttaataa gctctttaaa agaacgatgg catttatcgt 323041 ctcctatgcc aagataatta ctggctcaaa attgttcagc gttcataaaa ctttgatatc 323101 actttctggc gcacaagcta acctttatgt agttcttacg tagattcttt ttagcaagtg 323161 cctggtagtg gttattacat aaatgtatct tttcatttga taacaatttc ttcagtagca 323221 tgtcgtgtct agcacgtgac gtagaactgt ggcttttttg ttgtcattat gacaatcaag 323281 ataccaaaat tcagtcatgt ttaaaagggg aaggtacgat agagatatat ataaagtgtt 323341 caatttacta taattgcgta tagaatccat tgttacttgc tctcaatgaa acaacgattc 323401 attcgtcaat ttacgaacct aatgtctact tcgagaccga aagttgttgc caacaaatat 323461 ttcacttcta acactgccaa agatgtttgg tcgctaacca atgaagccgc tgcaaaagct 323521 gccaataact ccaaaaacca aggccgtgaa cttattaatt taggccaagg ctttttttca 323581 tattcccctc ctcaattcgc cattaaggag gctcagaaag ccctagacat tccaatggtc 323641 aatcaatatt ctccaactag aggtcgacct tcattaatta attccttgat taagttgtat 323701 tctcctattt ataacacaga attgaaagcg gaaaatgtta ccgtaacaac aggtgccaat 323761 gaaggtatac tttcttgctt gatggggctt ttgaacgctg gcgacgaggt tattgttttt 323821 gaacctttct ttgaccaata tattccaaat atcgaacttt gcggtggtaa agttgtttac 323881 gtccccataa atcctccaaa ggaattggat caaaggaata ctagaggtga agaatggacc 323941 attgactttg agcagttcga aaaagcgatt acatccaaga caaaagctgt cattatcaat 324001 acccctcaca acccaattgg taaagttttc acgcgcgagg aattaaccac tttaggtaac 324061 atttgcgtca agcacaacgt tgtgattata tctgatgaag tctatgaaca cctttacttc 324121 actgattctt tcactagaat tgccacactc tctccagaaa ttgggcaact aaccttaacg 324181 gtcggttctg ccggtaaatc gtttgctgct actggttgga gaattggttg ggtcttatcc 324241 ttgaacgcag agttgttaag ttatgcagct aaggcacata caagaatttg ttttgcatct 324301 ccatcccctc tacaggaagc ttgtgcaaac tctattaacg acgctttaaa aattgggtat 324361 tttgaaaaaa tgagacagga atatatcaac aaattcaaaa ttttcacatc gatctttgat 324421 gaattgggac taccatatac agctccagag ggtacatatt ttgtcctcgt tgatttctct 324481 aaagtgaaaa ttcccgagga ctatccctac ccagaggaga tcctgaataa gggaaaagat 324541 tttcgcattt ctcactggtt gatcaatgaa ttaggtgtgg ttgccattcc accaactgaa 324601 ttctatatca aagagcacga aaaggctgct gagaatttgt taaggtttgc agtttgtaaa 324661 gatgatgctt atctagaaaa tgccgtagag agattaaaac tactcaagga ctacttataa 324721 gataaatttt tttttatact cctttttctc aatatataga ttttataaag catgtatatt 324781 tttatgcaga agtggtaaat ataaacatca atattccaga ataattccat attttcttcg 324841 cgtactacaa gaaaaagtga acccttaatg aaaaatagac aatatgaaca tttagtaatg 324901 ttttgaacag tgtatttata gagtacttaa acacatatga agatatagcg caagtaaata 324961 taaatgagtg acaaatctca tcagatatat tgctactttt ggctctttgg tttgatcaat 325021 aatgtacttt atgtggtaat actttcagca gctgttgata tcgtgggtcc taccttgcct 325081 aaatctctag tattgctagc agatatattc ccatcactcg ccattaaatt gtgttcccca 325141 ttctttattg atagaatcaa gtacagctat agaatatggt ctttgatcac gatgagttgc 325201 ttaggaatgt tcttagtttc ttttaaaaac ttgtttgttt gtcttttagg aatatctttc 325261 gcatctatat cttccggatt tggagaagtg acattcctac agctaacaca ctattacaaa 325321 caaatttctt tgaatggatg gtcgtcaggt actggtggtg caggaatcat tggcggagca 325381 tcttatatgt tcttaacttc aatctttaaa gttccagtga agctaacttt actagtattt 325441 agtctccttc catttgcatt tttgttttat tttaaattag aatccaatga taccaacctg 325501 acttaccaaa gtcttcaaca aattgacgaa gcagaggatg accagttggt gccctttcct 325561 gtcgccttta cacataccaa cgcttcgcaa tccctgtatt ctacaagaca gcacattttg 325621 caaacggtca agagacttcg aagattggtt tttccataca tggttccatt gaccaccgtc 325681 tacttattcg aatatttaat aaaccaagcg gtagctccga ccctattatt tccgattaat 325741 ggtgatgaaa gaagtaaatc gatgccattt ttcttccata aatacagaga tatatacgta 325801 acctatggaa cgctctacca attaggtgtc tttatatcaa gatcctttgg acatcttatg 325861 agaatgagga gtttatacat cttagcgttt ttacaaggtg tgaatttgtg cataacggta 325921 ctgcaatcat ggttttatgt cacacattcg ccctgggcgg tgatgatatt aatattctat 325981 gagggttttc ttggtggtgc gtcatatgtt aacacattct taaatattct cgaacaagag 326041 gatcctgatg aaacagagtt cgccatgggt gctgtgtcca tcgctgattc ctttggcgtt 326101 tttttggctg cgttacttgg tttggggcta gaacccaaac tttgtaggca tcaaattgcc 326161 gatgacagac cttggtgtag gatggaataa agttttgttg tgatattaaa taggagattg 326221 aaataaagtg ttagatgctt tctatatact cattctaatg cctgctaata actcttcgat 326281 aattcgttga tttctatcat tactttgaat ggtactcaat atgccaaaac actgcagtaa 326341 tgtcaattta tctgtttctg tgacattact ttcttcttct tgattgaaaa tgtaaagttg 326401 aaaacttttg ctgataccat cgttactatt tacgaagttt tcataacaag gtaagactat 326461 tgaatctcta aagcacataa gcaaaagaaa cccaatagaa taattaccat taatgtgagt 326521 ccgactttca ttgcctgact ttaaaaccgt agaattacca tcttctctga tactctgatc 326581 caacggtaat aacacagcgg ctaaatcata atatacctct tgataaaata tccgccatat 326641 aacgcctaat cttttcaatg cgttatttat tgtgtcttca ttagaatagt taaaaacaat 326701 ttggttttct aaattgtata gggaactaac caaaaattct ttcaaatcgc tgataattct 326761 attcatgccg ctatgtgtga ctcttggatc tgtttttaaa atgcaataga attctaaaac 326821 ttcgttaaaa ttttctattt tggccctgag tttccatatt ctttgagttc tgaataattc 326881 tgctacgtta ctacaaaata tattccaaat attatttgtt agggttgtca gttcttggga 326941 gttgaagtgt ttatagttag cttccagaga tggtaaattt cttaaaaggt cgtgtaacat 327001 tgagaccgga ttcggtgagg caggatcagt tccagaaagc ggatcctcaa cgattgtgtt 327061 gggattgaca ccagatggat taacattcaa tgagtacaca gaagttcctg agtccacaag 327121 ttgccccgca ttagtatgaa taaattgtga cggagattta tgtcttccgt aagaggaatg 327181 cagaaattta ctcaaggaat ttggaattgc aggctcgata gcatcttgac caatgtgcct 327241 gtggctttta ttttggaaaa agttcttaat cacgtttcga aatgaatgtg aactattatg 327301 taaggtgctt gaatctgtca aaaaggaggc aggatccgat gaaatggtcg tatgtgctct 327361 gtttctccta ttaaaaaagc cagaagcctt tcctttcata tacctgccgg agggcgtgga 327421 gtgtaaactt ttctgagtaa tggatattgc atcagaagat aactttttag atagattgtt 327481 cgagcactcc accgtgtcaa cgctatgaga ttcccctatc tgagaagaac cagatttaga 327541 tgttgcagct gaggcattgt cattgctcct caaggaatga tttgaggcca cactgacctt 327601 cgatcgagga tgatctactg tatggaatat ggattggaag ccaacgttag aaacactagg 327661 gctaatgggg ttcctcgagc ccttcaaatt cttgatggaa taaacgtcat catttgatgt 327721 gtctacaaga gtttgccggc taatctcgct tgtagtctga aaatttttta ctggggctgt 327781 ggctaattgc acattaaggt attgttcgct attgacaggg cgttgtgtcg tagtagatgt 327841 tctttctcga aggagtatat cttctgctgt cataatgaaa gaactttatt tctacagagg 327901 tcaattggcg tttctgtcac ctagatcttt tcatttggtt attccctcta taaatttact 327961 catcggtcaa tttttctaac attatgcacc tttgtcaccg gcccttagaa gaggtgaaga 328021 tgattcgtga acattggtga taagcgagaa tattttctat aaatttgtaa agtaaaaata 328081 aattacgtgc tatttagttt gcaatgtgta cttattgtta gtatatgtat tttttgcatg 328141 cggcgatgaa ggccagtaaa accaacgctc ttgcatgctt acctctttca tcagctggtg 328201 atttaaaaac cattcccaac aatatcagtg acatataaga gagccacgac cccgttttgg 328261 tacacttaaa tatgattatc gttaatatca tagaaactag tttgtaacaa acctggattg 328321 ttctatttaa agcagaatac ttttggaggt tttgggttga tacggtgctc aaattttcct 328381 ctggtgctgg taatgataaa gtaacgttgt ctccgtcaat ataatcatca gtaaaactgt 328441 tggtattctc attcacttcc gagattgtac tgaagttcaa agtgctatcc acattttctt 328501 tccagaattt tttgccgggt ttggaattta ttagcatttc atctaacgtc tcctccactg 328561 tcttcgctgt gggtctagca tcattatttg gttgtaaaag agcgtccatt aggtgaaata 328621 ttctacggtc tattggtttc aatttcatcg cttgatgctt ttcaatcata ccttcagtgt 328681 cgaacctaaa atttttgatg cgtaccttca aatcaactat atccaactgt ggttcaaagg 328741 gcaattcacc gaagacaata aaatagcaaa tcattcctag agaatacata tcggaagcaa 328801 aggtgtattc attgtatgtg tgactcgatc ttgaaggcaa cgtagaagaa gaaactggtc 328861 tcccctggat aataaggtct ggtgctgtaa actctaatgt tcctgtgcaa ccagtaccca 328921 atctggactc tccttccaac tgactttccc ccaaatcgcc aataacaatt gatgggaaaa 328981 actcatctga attgtgttcc ctgtcgtata cgttgtcatt ctcattgtca cttttaaatg 329041 gagtcaataa taaacagttg gatggtttca agtccctatg tattaggcca atactgtgca 329101 gttcgtgtaa acctcttgca atatccctta taatggatac gagctgttcc gtagataggc 329161 caacttctcc tgatttaccg tgatttttct tgcgagttct aaattttttt ttcctctctt 329221 caggtgattc ggtatctgag aacctattga acacttttct tagaatacag tcttctaaat 329281 tgccgccact gcaatactgt tgtaaaatga aaatacaagg aacttcttct tgtgaatccg 329341 attggctccc atcaatggat ctgacaaatc caaccgaaga atccatttcg agccacacat 329401 gattatacgt aatcaaattg gcacttttgt gagttagcga actcaacgct ttcacttccc 329461 gtatgcactt attaaaccat tccatatcat ttccaatagg tatttttttt agtgcaaaaa 329521 cacctaattc agtattacca attgtgtgta caactttgta aacagaacct cttgcaccat 329581 ttcccagcaa agacaatatt ttgaaaaatt tacgaaagta tccggggata aacaaatcat 329641 ctggaataaa gtatttgttt ttgctgaact gtccctgctt attgttacta tcgttttgta 329701 gggcgtagtg ccgatgattt ctttccaatg actgaaaata tcttcttgaa aagcttgaat 329761 tggcaaattc aaatccaagt ggcacagtgt tctctggaat actgagccta ctgctttctg 329821 attctactcc agcagaggct cgacgatgaa gttgtcttct gtttataata tcagggttaa 329881 tttccgtacc acattgcggg cacacatagg aagcaatagg gcttttgtat tgatgaatcc 329941 ctgaaggaaa gtccagtgct gataaagatg cagtctggtc ttcatttagt tcagagtcat 330001 tattactgtt gtcctgttgg aaaaatgata aagttcctga ggttggatta acaaccacca 330061 ctgatttaga attaggatca tctaaaatca gcgaaccttc ttcatatggt actaaactca 330121 tttctaagtt ctacttatgc tatccctcaa actatatatc taatagtgtt tcttcggtta 330181 cctagttgtc actcatagga tctatatata caatgtcctt cccccccacc cccttttctg 330241 aaacgtatac aaaaaataaa gcttgaaata cgttattacg taaaaaaagt gtactgtaaa 330301 agcttacaaa aaagagtttg cgaaaaatta taaataaaaa gtagtctagg taaaatatga 330361 aatgtttcta attatgcatt tatgtgatcc tgaaaaccgc ccttcttacg ttggaccatg 330421 atgatcacat ttataaatat ggttttcttt ccaatgcgca tttcactttc tgtgagttca 330481 attttcccaa atcgtcaaag cttttggaac agtcagagca cttgtatttt ttctgatggg 330541 tcttaatatg tttgctcaaa tttgacgatt cgttgaatct cttaccacaa atcttgcatt 330601 gtaaaggttt ttcaccagta tgggttctta tatgaatctt caaagaactt gaaatcgcga 330661 attttttatt acaaatgtga catttgtaag gtttttcgcc agagtgtgtc ctggtatgct 330721 gaactaaagt ttcttcgctt gaaaaacacc ttttacatgt cttgcactta taaggtttgt 330781 atttcgaatg cacttttaaa tgacggatta atttttgtct ttgggggaac gtacgatggc 330841 agtcatgcca caagcattgg tattcagact taccccgggt taaatgtact gcttctaaat 330901 ggtcgtttaa ttcctgagca ctggaaaatg acttattgca accatcccat tggcaaatca 330961 cctgttccgg ctgcttgatt ggcggtatat tggaaacatc atttgcagac gtcatatcag 331021 gtgctccatc tgctttagaa acttcgtgtg tttgtgggtt ggggcaatgt agtaagtgat 331081 gtttttcctt tgatatacta ccaggcaaaa atgagtctgg gttggcaaat tgaatatcaa 331141 aattgatacc atgttgacaa ttaatatggt tcactatgga acatgtatca tctccaagga 331201 aatcacagtc ctcccaatta caagctaatg gttccatagg gtgtttgaaa tcttgagaga 331261 catgatcctt caaaagatgt ctttgtaggt caaatagtga gctacaagac tcaggacatt 331321 ctttccattt gcattttaag tcattgtttt tctcttcttt aaaacaccag ttgaaattta 331381 tagtgcttgt tgtctgtata ggaggagaga tgctagaagg taatgagtct tccaaagagc 331441 tgaaatcagt agattctaga tcttttgtag gccaagatct acgatttttc tgattctgat 331501 gagtgacttt gggtagcgaa gggggctcac tttgatttct aaatctttca taactatact 331561 ctcttgaaat taagtcattt aaatcgttgt tagttagatc ggctgttgtg ttcgccgcgc 331621 taatccctga attgttcaca atattgtttc tatttggttt gtgagaatga aactgtattc 331681 tatggtgatg gtgttgatga tcagttgaag ttgctccagc cgtattgtta ttgcttccat 331741 taagattatt tttagggttg catctattaa tgcttgataa tagaagattc attgtttggt 331801 taccgttttc attatttcct gtgctcgaac catcgcagcc gttaccggca ttattgtggt 331861 cgtggtggtt aatgtgtttt ccaaacggta cttcatacaa agaagaaata ttgcataaat 331921 cttccaaaat cttcaaatcc atatcagtat ttaagatatg ttcgtgataa gcatgatttg 331981 taccttgcaa agtgtttgta ggttttcgta aagatgaaca tttgggtggt agttgaggtg 332041 gctttgactc taaatgcata tgcttagaac aaggttgatt atcagtgctc tcctcacaaa 332101 atttgcagta tttatggaaa acgtcatcat tatttgatga ttgatgatct tgaacaaact 332161 tgtgaccact agtcgcgctc gtgctagccg tgcatggggt gtcacaggtc aaatcgcaat 332221 caatctccga taagtgagac atcagctgag aaaagctatc tggtacagta ttattgtgat 332281 tgtgagagtc gtgattggta ctattacagt actgatcatg aaggttaaaa tttggcatca 332341 agtgatcgtt ctttacatct gtgaatattg caacatcatt gccgttctca gatatgtctt 332401 tctttgtcgg ttgatcagat tcaccttgtt ttatattagc ctcacttttg ggatgagttt 332461 cgtcacaaca tatttccaaa atcttgggcg tacaataaca atcatcggat ccaggtggtg 332521 ggttcggttt atttttcttg gaagagggca gcagtatcag atcgtcgtta aaccaagaat 332581 cttttctacg tggtaggtcg cttttagaat tctgttgggg acttgtcgga tcagaagcta 332641 ccgaatggaa attgtttgca aaagaatgat tattagaatt atacgttgca gtatcattat 332701 attttgttaa tgacggatta ttgtgataat tcaagaactc gaaatgttgg cagtcggtgt 332761 actccttgca tttctcattg acgtggcaat caccacccat atcatggcta gctccagatg 332821 caaatgcgga agtagcggca tcagcaacag ctgcggctgc aggtgttgcc gaagcactac 332881 tgtcgttcac aggcgcgctg tggtgaaggt gaccatggat ataggtcagg ttgttgtagt 332941 tatggatgtg cccgtggaca atgccttctt tacctatcgt cagagcatca ggcttggcag 333001 aagcagcagt ggccgcactc gtggccatcg agtcatcgcg cttgggggag tccctgggag 333061 tcaacgcatc cattagttcc tatccttctt ctatttaaaa aaccgtaaca cataaaaagt 333121 aaaagtgtaa tgcttccgtc tcgccgctgg cctatattca cagtgactgc agttgcatct 333181 tatattgcca agcacgtttc atcatgacct ttagggtaga tgactgctgt caactactcc 333241 gtctgcagtg atatataatc atgttttggg cgtttaagga aggagaatta tttccaacag 333301 ttgaatagga agatccctag agtaaatcgc aggcaatcca gtactaagaa acggcgatga 333361 caatggaaaa aaatggaggt aatagcagcc gtggtggcca agtaggcggc aagtctgtgt 333421 gtgtttactg cgggtcttca tttggcgcta aggcgctata ctcagaaagt gcagaagaat 333481 taggagccct tttccataag ctgggatgga aattggtata cggtggaggc actactggtt 333541 tgatgggcaa gatagcaagg tctacgatgg gacctgattt aagcggacag gttcacggta 333601 tcattccaaa tgcacttgtg tctaaggaaa ggacagacga ggataaagaa gatgttaata 333661 aagcattgtt ggagtctgta gaaaatcata agggcgccac tcctatttct gaagagtatg 333721 gggaaacaac gattgtacca gatatgcata cgagaaaaag aatgatggca aatttgagtg 333781 acgcgtttgt tgctatgcct ggtggatacg ggacttttga agaaatcatg gaatgtatca 333841 cgtggtcgca actggggatt cataataaac caattatctt gttcaatatc gatgggttct 333901 atgacaaatt attggagttc ctcaaacact ctattcaaga acggttcatc agtgtgaaga 333961 atggtgaaat cattcaagtt gcctccactc cgcaggaagt tgttgataaa atagagaagt 334021 acgtcgttcc agagggccgt ttcaatttga attggagcga cgaaggtcac gctcacgagg 334081 attgtgctaa ataatagaaa cgtaagtcat gtatctagtt taaacgatct gtatagataa 334141 tgtggtgaaa aatccaaatt tttaggagct gtctttctaa gcccgaaggc tggaaaaaat 334201 agtactgatg gcaaagacat catagcttta aagtccattg ttctcaaaag aagctcaata 334261 gaccatgtct tctgaatcag gaaagcctat tgctaagcct attaggaagc ctggctatac 334321 caatccggct ttaaaagccc ttggtatacc cgccttgagg ctgccttctc gaaactggat 334381 gatcttttgg tctgtgttaa cagtatccat cggtggcata gcctatgaca aatacaagca 334441 acgtcagatt ctgagccatg caacagactt ggtgaagcct ttggcagagg agtccatgga 334501 ggtagacaaa gtgccacgaa agatcactgt ttttattgca cctcctccaa atgattatct 334561 ggagagttcg ttgaaagttt ggagacgata tgttaagcct gtactgtatt atgcagggtt 334621 ggactatgaa ttagttcaag aggataggca agggattatt agaactaatg tagccaacag 334681 aatcagagaa ttgagaaagg aaatattggc atcgacggat gggcagccag ttaaagagcc 334741 taaccaaacg gtagcaaaac caagtggttc ttcaaccagt aaaatttcat cactactacc 334801 gttcaataaa atcattcaag atcctgctga agaagatgac tcgtttgatc cagaaatcgg 334861 taaaaagttc aaggagaact tcgactggag aaacgttata ggtatcttct atacaatgcc 334921 aaaaccgaag catataataa gtgaagacgc cctgacaaag gaccctatat tatctggtgg 334981 tgttatttgt ttaggtagag gcgcctataa ggagtacatt gccggtattc acgaaggctt 335041 gcttggaccc atcgagaaga ccgaaaaaac aggatccact gagcctaaga tgactggggt 335101 tgtagaagca aatcaaatag aatcaaaggt aagtgaatcc ggtgctacgg aactggtgga 335161 tgccgagaaa gagactgctt tggaagaggc caaagtacaa gatgatctaa aggttgatga 335221 agaaaacagc tcagaggatt cgcaaaaatt tttgaagcca tttatttctt cagaccaata 335281 ccctgacctg caaatcgctt cggaattaca aactccaaat ggcgaattca taagaaaccc 335341 caatacaaat atcccgcttc tgattaatca gccgttattg gtcattccaa tacctaactt 335401 gataggtttt actaccattc caaggagaat acatcgtttt taccagaagc gtttctacgt 335461 agaggacgtg tgttcaagtg tagttaactg tgttcgacaa acccgtataa gaccgtttga 335521 tattgcaaag gatattgatt tggcgaagga cgaagaaaaa gattggccac agaactgggt 335581 caaacagggt aaagaaaaga acagcgaatg gacccaagaa ttagtatgtg atcctagaat 335641 cacgaagcat atgtttgttt acgaaaaacc acccaaggaa gagccagaat cagatattta 335701 attggatata tattatgttt tatcatcatg cacgatcgac gttatgtctg acatatacca 335761 aacccttttc gaagatttcc ctttactcat gttgaaatag tttttatata tgcacacata 335821 tacatatata taaaatctgt aaatataata aaatgtgtac attgtaaaag aatccaagca 335881 caactattat tagcattatg agtatttttt tcaagccgcc gattgatatt gagatccttt 335941 tcgataatga ggaatctcgc aaacacgtag acattgcaac aagatcaagt aattccagtt 336001 acaaatcaat gaaggaaagc ttgcccgtct atgaagatgg cgaatccctt ggtggaattg 336061 ttactttgag agttcgggat agtaaaaagg tagaccactt gggcataaaa gtgtccgtta 336121 ttggatccat tgatatgtta aaatctcatg ggagcggtaa ttcatcttct aaaaaagtta 336181 cctctagcac atcatcttcc tcttctaatg gttcagtaga tgtgcggaag aattcagttg 336241 atcaattttt atgccaaagc tatgacctct gtcctgctgg tgaattacaa cattctcaaa 336301 gtttcccatt cctattcaga gatttgagta aaagatacga atcttataaa ggcaaaaatg 336361 tggatgtagc ttactatgtt aaggtaacag ttatgaggaa gtccacagac atctcgaaaa 336421 taaaaagatt ttgggtctat ctttataata gtgtaactac tgcgccaaat accctttccg 336481 caaatgagac aaaggcaacc actaatgaca tcgctggtgg taactatgct gcagataatg 336541 cgagtgacaa cacgcaaaca aagagcaccc agggtgaggc ggcagacgtt aatcaagttt 336601 tgccgatatc acattcaaat aatgagccca agcctgttag attggatata ggtatagaaa 336661 attgccttca cattgagttt gaatatgcca aatcccagta cagcttaaaa gaagtcattg 336721 tggggcgtat atatttcctt ttaacgagac taaggataaa acatatggaa ttaagcttga 336781 tcacaagaga atcttccggc ctacaaactt ctaatgtaat gacagattcc actgctatcc 336841 gatacgaaat aatggatggg tcttcagtga aaggtgaaac catacccata agattattct 336901 tgagcggcta tgacctgacg cccaatatga gctgcaacta ctttaacgtc aagaattatt 336961 tgagcttggt tattatcgat gaagatggca gaagatattt taaacaatca gaaataacat 337021 tgtacaggac ccggtagaaa agctcgacct taaataaggt gaagatgtgg ttctctgttc 337081 tttcaacatc tcgatattta acttttcgtt tggcattata gtgttataca taacaatatc 337141 tagatttcag tagaagactt ttgcgtaagt tataacgaac taaacaagca agaggtaaaa 337201 tacgatatag taagaagctc aagtgctaaa actttttttc tctacgaaag gaggaatagc 337261 atatggtttt cttccctttt acagtgcttc ggaaaagcac agcgttgtcc aagggaacaa 337321 tttttcttca agttaatgca taagaaatat ctttttttat gtttagctaa gtaaaagcag 337381 cttggagtaa aaaaaaaaat gagtaaattt ctcgatggat tagtttctca caggtaacat 337441 aacaaaaacc aagaaaagcc cgcttctgaa aactacagtt gacttgtatg ctaaagggcc 337501 agactaatgg gaggagaaaa agaaacgaat gtatatgctc atttacactc tatatcacca 337561 tatggaggat aagttgggct gagcttctga tccaatttat tctatccatt agttgctgat 337621 atgtcccacc agccaacact tgatagtatc tactcgccat tcacttccag cagcgccagt 337681 agggttgttg agcttagtaa aaatgtgcgc accacaagcc tacatgactc cacgtcacat 337741 gaaaccacac cgtggggcct tgttgcgcta ggaataggat atgcgacgaa gacgcttctg 337801 cttagtaacc acaccacatt ttcagggggt cgatctgctt gcttccttta ctgtcacgag 337861 cggcccataa tcgcgctttt tttttaaaag gcgcgagaca gcaaacagga agctcgggtt 337921 tcaaccttcg gagtggtcgc agatctggag actggatctt tacaatacag taaggcaagc 337981 caccatctgc ttcttaggtg catgcgacgg tatccacgtg cagaacaaca tagtctgaag 338041 aaggggggga ggagcatgtt cattctctgt agcagtaaga gcttggtgat aatgaccaaa 338101 actggagtct cgaaatcata taaatagaca atatattttc acacaatgag atttgtagta 338161 cagttctatt ctctctcttg cataaataag aaattcatca agaacttggt ttgatatttc 338221 accaacacac acaaaaaaca gtacttcact aaatttacac acaaaacaaa atgatcagaa 338281 ttgctattaa cggtttcggt agaatcggta gattggtctt gagattggct ttgcaaagaa 338341 aagacattga ggttgttgct gtcaacgatc catttatctc taacgattat gctgcttaca 338401 tggtcaagta cgattctact catggtagat acaagggtac tgtttcccat gacgacaagc 338461 acatcatcat tgatggtgtc aagatcgcta cctaccaaga aagagaccca gctaacttgc 338521 catggggttc tctaaagatc gatgtcgctg ttgactccac tggtgttttc aaggaattgg 338581 acaccgctca aaagcacatt gacgctggtg ccaagaaggt tgtcatcact gctccatctt 338641 cttctgctcc aatgtttgtt gttggtgtta accacactaa atacactcca gacaagaaga 338701 ttgtctccaa cgcttcttgt accaccaact gtttggctcc attggccaag gttatcaacg 338761 atgctttcgg tattgaagaa ggtttgatga ccactgttca ctccatgacc gccactcaaa 338821 agactgttga tggtccatcc cacaaggact ggagaggtgg tagaaccgct tccggtaaca 338881 ttatcccatc ctctaccggt gctgctaagg ctgtcggtaa ggtcttgcca gaattgcaag 338941 gtaagttgac cggtatggct ttcagagtcc caaccgtcga tgtttccgtt gttgacttga 339001 ctgtcaagtt ggaaaaggaa gctacttacg accaaatcaa gaaggctgtt aaggctgccg 339061 ctgaaggtcc aatgaagggt gttttgggtt acaccgaaga tgccgttgtc tcctctgatt 339121 tcttgggtga cactcacgct tccatcttcg atgcctccgc tggtatccaa ttgtctccaa 339181 agttcgtcaa gttgatttcc tggtacgata acgaatacgg ttactccgcc agagttgttg 339241 acttgatcga atatgttgcc aaggcttaaa taaagcaatc ttgatgagga taatgatttt 339301 tttttgaata tacataaata ctaccgtttt tctgctagat tttgtgaaga cgtaaataag 339361 tacatattac tttttaagcc aagacaagat taagcattaa ctttaccctt ttctcttcta 339421 agtttcaata ctagttatca ctgtttaaaa gttatggcga gaacgtcggc ggttaaaata 339481 tattaccctg aacgtggtga attgaagttc taggatggtt taaagatttt tcctttttgg 339541 gaaataagta aacaatatat tgctgccttt gcaaaacgca catacccaca atatgtgact 339601 attggcaaag aacgcattat cctttgaaga ggtggatact gatactaaga gagtctctat 339661 tccggctcca cttttagtcc agagattact tgtcttctta cgtatcagaa caagaaagca 339721 tttccaaagt aattgcattt gcccttgagc agtatatata tactaagaaa ggaatcatac 339781 tctcttatgt gccataattc tgttaggagc ggaaataagg ctggtttttt ggggatcaag 339841 ttcggaagtg ctcttctctc aattgccaca ggtgccattg ctatcgcatt gctatgcaag 339901 ttccacgacc acgaagcggt actgatagtt attgtatgct cgacattgtt atatggaata 339961 ccgtcactga tatcgtttat cacagagact gtttttgcgc ctagcaagtt tcatattgga 340021 tacttttaca acgttcttaa ttttgcattg ccactgatca ccatgggctg cacagtggac 340081 tattttcata ataccttgag gagcccaata tcggtacaaa gcgagtctca cagagtctat 340141 ataacaactc tggattcttt gttaattttc acacttttca ttaatggcat acaattagga 340201 ttcttcctga aggatggcaa tgcgaacaat ttcggcagct catctaacaa tattagtacg 340261 gatcaatatg acaaagaagc aaatgcggtg gaaaatggta gatttgtacc ccttaagaac 340321 tcttcacaga ccttaacacc agatttggaa ttattacacg gtagtcccaa gagtatgaat 340381 ggggtagcgt ggctgattaa tgaactctcc acaaattcaa acacaaacgc aaacaaaacc 340441 atatcatccg atgaaaattc aaactcttca gttattcgac acaaattagg accgattagc 340501 accagcaagt gtcctaaaaa gccatctcat tcgcattttt ctaaattgaa aaaatataac 340561 agtttctttt tgggtcctaa agaaaatcga tacaaaagaa atacacaaca agctactaag 340621 gttccgacag aaaagaaaag caaccaccga agtagccagt atgtatccag actatcaacc 340681 atatctgaca tctcgaaaag tttcctgaat ttcttagcat taaacgaaaa aaacgggaat 340741 tcgacttcca ctgcgagaac accaagtgaa ggaagagttt caataataat taacgaagga 340801 aataatactt tgaaatacaa aactccccat gattcgcata ctattgattc tccaaacttg 340861 gagttagaaa gagaagctat tgggagaatt aatagtgcct tacttcctgc atgtttgaga 340921 gtaacagata aaatgatatc cccacagcaa agcactcaaa atgaggactc ataccaagca 340981 acaccattga taccccaggt ggaagttgac gatgatttct atgtaggtga tatcttaatg 341041 actaatgaac tacaagacat tccacaagtc ccaaggatat catctgatat agaagacgat 341101 ttcgaacaac aatataccaa acacgtggat ttgccagccc gtgtcacttt agagatgtgg 341161 gaaaaggatc aggagaaaat acttcaaaaa gtaaccacaa accgggataa aagcaaatta 341221 ctaccccctt tcagattcac ctctgaaagt gatatggatc caagtacatc caccgaattg 341281 gaagttgaac tgcatgccca aaacaacttc agctttccct ttaaaagtgc aggattacaa 341341 attgctacat cagaccaatt taaccaacag gagtttaaaa cttcagatac tattagcgaa 341401 ctagatgagt atttacatga tcccagcatt caagaagagg atgcaagtca gctgattgaa 341461 agcagtttga accaaaacaa cctatcctca actactattg acaatggccc aaaggatatg 341521 agtagattta gtacaaggca ttcaccaacc aaatcgataa tttccatgat cagtggatca 341581 ggaagtgtca agcaccaaca ttcacacagc accctaagca acttttttac gggtcattca 341641 agaaacaatt ctcaaataaa tcagctatta cagggttctt cttctaatat gatgtccaac 341701 acctcaccgc attcatctcc aaccaagtcg ttgagaatga gatttggaaa gaaattgtca 341761 ttatcaaata tctctgatac aatgtcgcca tatgagggta gtacaacaga tccgataaac 341821 tactcgtttg gccatggtca caataaaaac cagagtattg attttagcta cgtacgtact 341881 ttgcaaagca gtcattcacc tacaaaatca acctcgggaa attctcgtcg ggattcttta 341941 aacaatgata gaacccagag tactgttaat gaaagagcgc ttagaactgc aagtacatta 342001 ttctatctcc agcacaataa cgccacatgt acattgaacg gagaggagcc agttctggac 342061 acaccacaat ctatacagtc atcatcaagc ggttctgagc aagaatcggc gggatctggt 342121 tctggctatc cagaagtagt gttcagcgag tatgatagag aaaaatggaa tgttttgagg 342181 aatctaaaag agatagcgcc cgaaaaaact atagagagcg gacctgttga agaactagtc 342241 tctcccagta aataaaccaa ccgacttatt catatgtatc aaagatacct atgggaactg 342301 ctaaaagcaa ctattttgat cccgtagaac acgatttatt tcattaaatt tttttttttt 342361 tttttttttt tcactttctt gcgatgagat gcacatagta aaagaaaagt ataccagtgt 342421 agtgcgtaaa ttaataccta tataataatt cattttcggt gactcaacat tccctgccta 342481 tattttaagc acctgcaaga aatatagatt atatacgaag gatggattct actgatctgt 342541 tcgatgtttt cgaggaaaca cctgttgagc ttcctacaga tagtaatgga gaaaaaaatg 342601 ctgatacaaa cgtaggagat actccagatc atacccagga taagaagcat ggccttgaag 342661 aagaaaaaga agagcatgag gaaaacaaca gtgaaaataa aaaaatcaaa tccaataaga 342721 gcaaaacgga agataaaaac aaaaaagttg tagtaccagt gttggcagat tcgttcgaac 342781 aagaagcctc tagagaagtg gatgcatcga aaggactgac aaattcagaa accttacaag 342841 ttgagcaaga cggtaaagtc agattatcgc atcaggtccg ccaccaggtt gcactaccac 342901 cgaactatga ttatacgcct atcgctgagc ataagagggt aaatgaggct cgtacatatc 342961 cattcacatt agaccctttc caggacactg caatctcatg tatagataga ggcgaatctg 343021 tgttggtttc tgcgcacaca tcggctggta aaacagttgt ggctgaatat gccatcgcac 343081 aatctttaaa aaataagcaa agagtcattt atacctctcc aattaaggct ctatcaaacc 343141 aaaaatacag agaactttta gcagaatttg gagatgtcgg tttgatgact ggtgatatca 343201 cgatcaatcc ggatgcaggc tgtttggtca tgaccactga gattttgaga agtatgttat 343261 atagaggcag tgaagttatg agagaagttg cctgggtcat ctttgatgaa gtgcattaca 343321 tgagggataa agaaagaggt gttgtgtggg aagaaacgat tattttactg ccagataagg 343381 tccgttacgt gtttttatcg gccaccattc caaatgcaat ggagtttgct gaatggatat 343441 gcaaaattca ttctcagcca tgtcatattg tctacacaaa tttccgtcca actcctttac 343501 aacattacct gtttccagcc catggagatg gtatttatct ggtggttgac gaaaaaagta 343561 ccttcagaga ggaaaatttc caaaaagcaa tggcgtccat aagtaaccag ataggtgatg 343621 atccaaattc cactgattca agaggtaaaa agggtcaaac ctataaaggt ggctccgcta 343681 agggtgacgc aaaaggtgac atttataaga tagtgaaaat gatttggaag aaaaagtaca 343741 atccagtgat tgtattttcg ttcagtaaac gtgattgtga agaattagca ttgaagatgt 343801 ctaaattaga ttttaattct gatgatgaaa aggaggcttt gacgaagatt tttaacaatg 343861 ccattgcact attaccagag acagacagag agctacccca aattaaacac attttaccat 343921 tattaagaag aggtatcggt attcatcatt ccggtttact gcccattttg aaggaagtca 343981 ttgaaattct gtttcaagag ggatttttga aggtgttgtt tgcaacagaa acattttcga 344041 ttggattaaa catgcctgct aaaactgttg tctttacatc ggtcagaaag tgggatggtc 344101 aacaattccg ctgggtttca ggtggagaat atatacaaat gtctggtcgt gcaggtcgtc 344161 gtggtttaga tgatcgtggt attgttatta tgatgattga tgaaaaaatg gaacctcaag 344221 ttgctaaagg aatggttaag ggccaagcag ataggctaga ctcggctttt cacttaggat 344281 ataatatgat tttgaactta atgagagttg aaggtatctc tccggagttt atgttggagc 344341 attctttctt ccaatttcaa aacgttattt cagtaccagt tatggaaaag aaacttgctg 344401 aactgaaaaa agactttgat ggcatcgaag tcgaagatga agaaaatgtt aaagaatacc 344461 atgagattga gcaggctatc aaaggttacc gtgaagatgt tcgtcaagtt gtcacccatc 344521 cggcaaacgc cttaagtttc ctacaaccag gcagattagt tgaaatctct gtcaatggta 344581 aggataacta tggctggggt gctgttgtcg attttgctaa aagaattaac aaacgcaacc 344641 caagtgctgt ctatacagac catgaatcct atattgtcaa tgtggtcgtc aataccatgt 344701 atatagactc tccagtcaac ttgttgaaac ctttcaaccc taccttacca gaagggattc 344761 gcccagcgga agaaggtgaa aaaagcatat gtgctgttat tcccataact ttggattcaa 344821 tcaagtcgat tggtaatttg agactatata tgcccaaaga tattagagcc agcggtcaaa 344881 aagaaactgt tgggaagtct ttaagggagg ttaatcggag gttcccggat ggtattcccg 344941 tgctggatcc tgttaaaaac atgaagatcg aagatgagga ctttttaaag ctaatgaaga 345001 agattgacgt tttaaacaca aagttatcct ccaatccctt aaccaattcc atgagactag 345061 aagaactata tggtaaatat agtagaaaac acgatttaca tgaagatatg aaacaattga 345121 aacgcaaaat ttcagaatca caagccgtaa tccaactgga cgatcttcgt cgccgtaaaa 345181 gagttttgcg ccgtttagga ttttgtactc ctaatgacat tattgaactg aaaggtagag 345241 ttgcatgtga aatatctagt ggtgatgaac tgttactaac agaattgatc ttcaatggta 345301 atttcaatga gttgaaaccg gaacaagcag cagcattatt atcatgcttt gcattccaag 345361 aacgctgtaa agaagcgcct agattgaaac cagagcttgc cgaacctttg aaggctatga 345421 gagaaattgc agcaaagatc gctaagataa tgaaggattc taaaattgaa gttgtagaaa 345481 aggactacgt tgaaagcttc agacatgaac taatggaagt tgtttacgaa tggtgtagag 345541 gagctacttt tacgcaaatc tgtaaaatga ccgacgttta cgaaggttcg ttgatcagaa 345601 tgttcaagag attagaggaa ttggtgaagg agctggtaga cgtcgccaat accattggta 345661 actcttcact taaggagaag atggaagctg tcttgaaatt aattcataga gatatcgtat 345721 ctgctggttc tttgtattta tagttaatca cacacaatta tgtattttta ttggtatata 345781 taataaacaa atagatttca tcaacattta ttatataata acatttttgt ttgggcaagc 345841 acactattga tacacccata caactcaatg aagtgcagcg ttagtagaga caataagagg 345901 agttttaaat tcttaaacta tatctggcaa aacaccacca aagccagcca aatagtatct 345961 cactgtatct gaatgaaagt agatttacca gaatccagac taccatcttt atatagagat 346021 tttaggccat tgaaagattt aaatcccgat gggtacgaag caaacatcag tacatggagg 346081 gatttcttct tgcaacaata catcagcaac tccaacagaa tcatatttac tatagggaca 346141 aggactttgc aagaattaac tcatgaagtt tatggcgtac cgaaaagcat tgatatagca 346201 attgacgttc ttgttaatga aggaaatttg atacctatgg aattattcaa tcttggtgga 346261 atgtacactg acaacagtag aaaaggattt tggaagtggg ttagaagttg gaaggagtct 346321 acaaacatgt ataaaagccg gaaggatgaa acaaatttct acttgagaga agacaaattt 346381 attatcaaag caaatttgga aaaagagtat caaaggtttc atgaattact caaaagaagt 346441 gtttttatgg aggcttcatc tattacagat ttagtattca caaggaatga atttgtgacc 346501 acagaaagtt tgcagtcgtt cttttcaacc tatgatgaag aaacgaaaaa cgtgttcctg 346561 cactttatag agaattataa gcacataata gtttcaaaag acaatgttat caaagtcatt 346621 gccgctgaag tagaagacat tactagcagg ttctccaaag gcatcacaga aaatgacctt 346681 cgaattgcta gtgttaaagt gggtattata aacatcaaca aacaaattac aaggctaaga 346741 aaagaaatta atgaatctaa cattaaactg agaggaccag agtttaatga gctgccgaag 346801 agaataagga ttgaatataa acaggcgaga ttactatctg aaaaacatct ttctaggtta 346861 ctaaagtttc aaaataacct cgctcaagta agaactcaaa tagacaccag tgctactaat 346921 gcggttttaa ttcaaacttt aagtgaatcc aacgaagtaa ttaagtcaat taatggatat 346981 attggttcta ccgaaaaagt agaagactta ctagatgaga ttaaagaggg tcatgaccgt 347041 accgaagagg tcaatgattt attagctcat tataataaag gtcaagacga agaagcagaa 347101 gaagaaattg aaagagaatt agaacaatta gaacttgatg aaaagaataa taataaggaa 347161 gaaaataaga accaggattt gcacgagcca aaagaaagca gtagcgagga tctattaaag 347221 agattgaata atctgaagat aaatacaaat gaaggacctg tgcaagataa tgaaaaccac 347281 gataatgaga taagaaaaat catgatggaa gaacaaccac gttgacgaac tgagtgacta 347341 ataaataaat atatatgtat aaataaaaaa taaatatgaa tattttaata gacggaagaa 347401 agaaaatatg tgtgaataac caaataggaa ataaacaaaa gcacatttaa ttgttgccgt 347461 tattattaga gtaacctaat gtacgaactt tggtattaga tgcagaatta ttggaagaca 347521 agtttagttc agacacgttt tgtcgcaatt gagaagtacc attagaagga tacatccttg 347581 gggtagtata tgctgaagga gtcattgaat caccaccacc tcctcctccc ccgtccgaca 347641 ccatgtctaa gctagataat ttttgtaaag agtagttggc gctgtttgac acatttgtgc 347701 ccaacctctg gtaaccaaga cgggaggagg aagcatctac ttccggttct ttcgcccaaa 347761 aagatgtcaa acctgagtaa accttgtgta gaagagaaga ttgttccatg tagtcgaatg 347821 ttttgttatt ggcttccagc ggttctaaga tgagagtcga tctgggcaac agatccaact 347881 cttgcaaact tttgagttcg tcatttcgcg taagagtcac tcttggtata tttctgtgga 347941 aaaggtaagg tgttccatca tcgtagcaat tatagtctaa ccacatcctt actttgtgta 348001 attttgtttg aggagggaaa gtattagaga ttgtgtaacc attgggcagt ttcaattgta 348061 gagtacagta gttctgggcg agaaacccct tttgactctt gtaactaaca ttatcagtaa 348121 ctgtcaactg cttccacttc tgtggctttc tttgcgggtc attagtattt tgaaaaacat 348181 acttcctctc caacttgtcg ttctgaatca ttcttttgac tctttgatat tcttcattgc 348241 tcttggaaaa taacttcctc tttgttactt gacccttaaa gactgattgt aacccattga 348301 taaaggtttc ccaaggatcc tgctcacgag aaaggctatt accttggata gaacattcga 348361 gtagaccgtt ctgtaatatg ttaatgcttg gcgccgatga ggaggggaaa atgctcttga 348421 aaagcaagca ctctttagta ccatttacta accttaccca cagtatgttt tcgcgctcct 348481 cgtcactaag atttcctggt ttgaaccact gatgaagcca agaattgtcc ccggctgctg 348541 aactaatgta aacgacgata acctgctcac tagtatgaga gtaatcatga acaactcgat 348601 catgaaagag gctgtctata cctgacatct cgtacatttc tgttattcaa tacctgtaat 348661 tcacttcctt tgagggtcaa aaatgtcccc tgtaagcaag tgtataagta tataattata 348721 tatatgtgca tatatatgtc cctatacaac tactaacgaa tcttaaaagt tgactattca 348781 tgtggaaaaa gtccctcttc tagggttgac gcgctagagg taaatccatt aaggttcctc 348841 ctggcttcgt taactccgaa aagaatagca tgtgcaagat gagttaccga aagaagcaat 348901 aaagaaagca cgagtacatg tagaacaggg gcacagataa taccagacag atgagcccac 348961 ttttaagagt ttcaaaactt ccacgaatgc acagggagaa taaagtacgc gctgggtccg 349021 ttacgattcg tgctgcaaga ggtttaaaat cgctccacaa tggtctcgcc cctcggccct 349081 tctccaatta caagcatatt actaatacag ttttcgtttc ttttgtaatg ttcagatagg 349141 agcgaaagac taatttcgat ggaaattttt atcttcattt cgatagtatg ttcaatcagt 349201 tgaactatgc atctttggtt atcatcatta acaaattgaa acgaaaagct atcctgccaa 349261 gaaggccgga tagagagatt gaaaaagata tataaagtgt ccttgtcaca ctcatacaac 349321 acctgttgta tgtcaggcat acggcaaatt gactacagtt tgcatttgca ctaatgtcgt 349381 ttgcagtgta actgttgtat tgaacgtgga caaggacaag aaagatagtt tttatctctt 349441 gatgtttttt tatatggagg agaaagcgac gaagtcgaaa aaaacgaaag gaaataaaat 349501 gctgtcggaa aaaaagttag ggctggtacg gattataaac tatctcagta gttaggtaat 349561 atataagatg gcaccagtct tagtacttgt aagttgctgt tgattcgtcc ctagttatga 349621 atttgtctcg taacaacttg gccaaggcgt ctttgaactc accaacacta aagcctttta 349681 tctgctgctt taccgtttca aataaatggt cgtagtctag cccattcctc tcgctcttaa 349741 cggatctagt tatgcatgcc tttagtaatt cttgggtcca ttgggaatta cttccttcgt 349801 ggtgtgcaga actggttctt tcaccgcctg tgttgctact ttggagagac gcggttctcg 349861 gtagaaccac acgtagtttc ccatttttca cttttttcat atcaggtttg aagctctcgt 349921 tgatactgta tgtgttgtca atatctcttg tcagaatttt ataattgcag aaggatttta 349981 agactagcgc taagtctttg tacgccagtt tcgtttgctc tgatataact tgcaaggtca 350041 aatgatcgct ttcgttgaat aaagtcagca cacatgtttg gaaaagggtc aattcaaata 350101 ttaggttagt tccatcctgt atgatataag gcgactccac ttcgcagtgg tgcaagttcc 350161 acatcggata tagctctttt ttggaagcat ctgaatcttc cactttattc tgctcgtgat 350221 aattacggag aaattggttc cacgtatcat ccatctcttg aggtaggaca aaatttttct 350281 ttacttcgtt ggattgctga aaaactttgg gaattctttc tctatcaaag ataagtggga 350341 aaaatgactt gctgttgttt tcattgtatg tcttcccgaa cttcacagca gcctcgatat 350401 tctcataaaa cgacaagaac gatgcatatt tgattctcag atctgccata acctctaccg 350461 gctgaaagaa ttgcgataaa tagggttgat attgatctcg gtatcgcatt tcatcctctt 350521 gtgagacatt tgttatgatt ctttgtttga aaagttccat gaggctgtct ttgtaaacag 350581 gtaatatatc cttaataaat gaggaatttt gatcactttg taagatcgtc tttctgaaaa 350641 ttgatctttc gaaaaaatta ggaaatgtgg gaaggttaac gaacttcagt ctcaatatag 350701 gaagattttc gttgagatac tttattttca tatctctggg taggtctttt ttagttgttt 350761 ttatctttct gacgatgatg aataaatgtg actcaaaata tttgacatac tgttctatgg 350821 ctttgctggt acttccaagt aaattacata aatggtactc gatggaatcg gagtatattt 350881 tgaggtgatc tacattagct agctgaacta cctcatcaaa tagcctttca gtatcatgat 350941 tggatccata tgctgccttt aacttttctg aaacggcatc atcacagaat tccttgaatt 351001 ttgacagcat attttttgct tcaaaagcat ttctaaacat caataagcta aagtgtgtct 351061 cagttttgaa atatctctct ttttcttcat cataagtgtc cttcccaatt tctatgtatt 351121 cgctaataga cttcttgttc aacagtagat ggcttataaa taggtcattt gcatcgctga 351181 cccattcagg ggaaaataaa gatgctaata atgcattcct cgtcaatagt accttaaaat 351241 tcttgaaagt ttccagcctc ggccttaaat ttgattcctc acagtaatat tgtctgagag 351301 ttttcatata aaaatctttg gggctcaagc cctctatact aaaattgcag ttagacatta 351361 tacggagcat aggaacttcc ttctctaaca ttgtattcgt tattggaaac atatgaatat 351421 agtgatgaat agtagcgctt acaagggtgg aaaattccct tccaaaatgt gacttcatac 351481 attcgaaaag tttggaatca taatactgaa atatcgttaa ggtctcaaat cctagttctt 351541 ttcttatcat gggataattt accggcacat acgatataat aggaccaacg gcacccatta 351601 cgtactgaaa tagcttgtaa aaagaggtcc aatttttggg tataatttca taagaatagt 351661 cgcatctggt caaaaagcta aggacgtgcg cgtcaattat taactttgcc aattcatcac 351721 aaaattcttg aaaactcagc acaatttggt gttgatgtag cagctgaaac ttcttttgct 351781 tttcgtcatt cccattaaat tctgagttgt aaggaatgta tgatttcctt tgcgttaatt 351841 cacggcaatt gttcaacatc ttaggcatta gctttctaaa tttagcggcc ttttctttat 351901 tacactccaa ttctttcacg tcagtttcag ttatagtttc agctaaagta aggtgaaaaa 351961 actcgtgcag ctcagcaatc atcgttcgat acctgggatt tcgctcatcg ttaaatttat 352021 tgtatagtcc taaagcgttg cttgcactcg tctctctgct tatagactcg tggaatcctt 352081 ctctcttgga aacgctctca tttatcattg ttcctgtgaa cccgtacgag aatttatacc 352141 agtaaaaaag attggtgggt ttaatatctt gaggattcct tcaaagtagt cttttagtgc 352201 aaagatatcg atgatcttca ttcgcattgt tcatattcat cattacgcaa aggatagcta 352261 tgcgttccgc ttcgtcatac ttaatcagga atattgaaca tccaaaaatc tccgagctca 352321 cgtatgtaga atttttgatg aatacaaaag aagaaaacac tagacttttc tttgatgttt 352381 acattatgtc tatgatgcta agtaattggg cactctcccc tcgatatgtg ggacagcgaa 352441 acctcataca ttgcaccact ttatttcaca cacttacacg atgggcaaaa gacgcagacg 352501 ataaatatca tgatataaac tcaatgtatg aaaacatgtt tacaccttca aatgataacg 352561 tttcaatttt gcaggatgaa ggtaaatctg attatgatac gacgaaggcc agctctatgg 352621 aagaagatat cagtgctttt aataaagact tgtacaattt ctataatatt ggatatgcca 352681 aacagatcat gtctgcttca caattggaaa atatagtaaa ggcaaagggc agatttgtta 352741 tacaaagttt atccaccagt ccttattata atttggccct tgaaaactat gttttcaaga 352801 atacaccaag agccaaaaga ggtcccgata attgcagact gttattttac atcaatgata 352861 ggtgcgccgt tataggcaaa aaccaaaatc tgtggcagga agtagatctt gctaagctga 352921 agagtaagaa tttcgaacta cttagaagat tttctggagg tggcactgta ctgcatgatt 352981 tgggcaatgt taattattca tatttaacat caagggagaa attcgaaaca aagtttttca 353041 acaaaatgat aattaagtgg ttaaattcat tgaatcccga actaagacta gatttgaatg 353101 agagaggaga tattattcag gacgggttta aaattagtgg cagtgcttat aaaattgccg 353161 gtggcaaagc ataccatcat gcaacgatgt tgcttaatgc ggatttagaa cagtttagcg 353221 gcttattaga accctcacta ccgaacaata tggaatggga gtcaagtgga gttcatagtg 353281 taaaatcaaa aatcaaaaat gttggtataa ttactcctaa tcagttcatt gcagtggtat 353341 ccgagcgttt tcagaaaaca ttcaaagttg acggcgaaat acctatatat tactgtgacg 353401 agtttaaatc tataaacgat gagattaaag atgctatgaa caccttacag agcgaacaat 353461 ggaaatattt ctcggggcct aaattttcag tgaagattaa agataaaggc ttaacaatta 353521 aagtcgaaaa gggcatgatt tatgattgtg atagaaatga tttaatcggc ttggaattca 353581 aaggattttt ggagaatatt gacagttaca cataacgttg atgaatattt caattcactt 353641 gtaaataacg taggtaaata tcaaaattaa agtctttcac cggaaactga ttcagcatat 353701 ttcagcagac gcgtcctaga ttcacagcaa acttcaatat aagcgataca ttaggagtgt 353761 tcgtacttta gatctataag aactatattt tgttacgatt cagccgtctc taaatgtgaa 353821 ctaaatattt atactgttat ttgagaaacc gacagatagt acttaatttt atcgatcatc 353881 taagaatagc atcggtattg tggtgacatt tattgaattt cttccgctcc agaataaagt 353941 tccttttcac ttcaaaaaac tgccaccagt aaagttgcac cagtggtttt tgagcatttt 354001 ttgtcaatgt cgcttaaccg ttcttgaact gtatcctctt gacgtcgata aaatcatttg 354061 taaaaaccag gccaaatcat cattgaataa tttacactgt gtcttcaatg tcgccatttg 354121 gaccaataat tatcaaactg ttcacaattc actcaaagtc ctttcagcaa cattcttatg 354181 aaacaatact ttctttgaat ttgtatgatg aaacaaaatt ttttggttat taatcattta 354241 tcactctcgg tagccaagtt ggtttaaggc gcaagactgt aatttaccac tacgaaatct 354301 tgagatcggg cgttcgactc gcccccggga gattttttta atgtgctcta aatagaatgt 354361 ggatgaaatt tctcttggcc gccgtaccct tcttcataat taataatttc tttccatttt 354421 gcaggattat atctgatcaa taagtgattg taaagatttt gtttgtgaga aatatgtgaa 354481 tttttaattt tggttataac ttaataattg ttggaattcc atttttgata aagatgaaaa 354541 ttggtgaatt ttgagataat tgttgggatt ccattgttga taaaggctat aatattaggt 354601 atacagaata tactagaagt tctcctcgag gatctaggaa tcctcataat ggaacctata 354661 tttctatata ctaatattcc gttttattcc ttattccgtt ttatatgttt cattatccta 354721 ttacattatc aatccttgca cttcagcttc ctctaacttc gatgacagct tctcataact 354781 tatgccatca tcttagcacc atatatgata atatattggt agtatgacta ctagttgata 354841 gactgaagag aatgtggatt ttgatgtaat tgttgggatt ccatttttaa taaggcaata 354901 atattaggta tgtagatata ctagaagttc tcctcgagga tttaggaatc cataaaaggg 354961 aatctgcaat tctatacaat tctataaata ttattatcat cattttatat gttaatattc 355021 attgatccta ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt 355081 tctcatcatt tgcgtcatct tctaacaccg tatatgataa tatactagca acgtaaatac 355141 tagttagtag atgatagttg atttttattc caacatagac gatagttgat ttttattcca 355201 acagtgttga catataaata ctagtcaact aaatggtaat tggttattat tcctcaacat 355261 tctgctacca aacgcaaatg tagtaggaga gtttagattt tcaacgttgg tttgcgagat 355321 tggtgaaatc aaagcatagt ttacctttaa tcccaatctt ccaacaaaca gtagctcgcg 355381 tggcgtaatg gcaacgcgtc tgacttctaa tcagaagatt atgggttcga cccccatcgt 355441 gagtgctttg tttcttccgt gatagtttaa tggtcagaat gggcgcttgt cgcgtgccag 355501 atcggggttc aattccccgt cgcggagatt ttttttgaag ctgttgtagt tactacttta 355561 agatccagat tgatacagta cgtatgtgag gcaacagata cttgcaatat aacaagtttt 355621 gtgaagagat agtgtgaata cctatggttc cacgcaagaa atcatctatt tgaattttcg 355681 gcttctataa gaatgacaaa actcatagga agctgcaatg cattaatttt ccgtaagctt 355741 tattaacccg ttagccgctc aagtcgcttt tctcaggtcg cgctcctctt ctccggactt 355801 atgtggctcc ctttagaata taagggtctt ccctttaacg gaacagtaag gttccacaag 355861 gtggcaaaaa aggcaatcca accgacactt cggcaaattt ctttcactct agtcagagct 355921 aagttcttat atatactttc taaataatta tctgctaaaa taagaaaaga aggagcctaa 355981 atacgtatat ctatatacat gtatacacgt gagctaataa attatgttat ctttgaaaaa 356041 aggaataaca aaatcataca tcttgcaaag aactttcact tcttcctctg ttgttcgtca 356101 aattggggaa gtgaaatctg aatcgaaacc gccggccaaa tatcatatta tcgaccatga 356161 atatgattgt gtggtggtag gcgctggcgg tgcaggttta agagcagctt tcggtttggc 356221 tgaagctgga tacaagactg cttgtttatc caagttgttt ccaacaaggt cacatactgt 356281 ggctgctcag ggtggaatta atgctgcgct gggaaatatg catccagatg attggaaatc 356341 gcacatgtac gacactgtca agggttctga ctggctcgga gaccaagatg caatccatta 356401 catgacaaga gaagcaccta agtctgtcat tgaactagaa cattacggta tgcccttttc 356461 gaggactgaa gatggaagga tttaccagag agcatttggg ggacaatcca aagattttgg 356521 taaaggtgga caggcctata ggacttgtgc ggtggcagat agaacaggtc acgcaatgct 356581 tcatacattg tatggacaag cgctgaaaaa taatacacac ttctttattg aatactttgc 356641 aatggatttg ttgacccata atggcgaggt tgtgggtgtc attgcctata atcaggagga 356701 cggtacaatt cacagattca gagcacataa gaccgtcatc gcgacaggcg gatacggtag 356761 agcttacttc tcttgcactt ctgctcacac ttgtacaggt gacggtaatg ctatggtttc 356821 tcgcgctgga tttccactag aggatttaga atttgttcaa tttcatccgt caggaattta 356881 tgggtctggc tgcctaatca ctgaaggtgc ccgtggtgag ggtggatttt tattgaattc 356941 tgaaggagaa aggtttatgg aacgctatgc tcctactgcc aaggacttgg caagcaggga 357001 tgttgtttcc agagcaatca ccatggaaat cagggctggc agaggtgtcg ggaaaaacaa 357061 ggatcatatc cttttacaat taagccatct accacctgag gtactaaagg aaaggctacc 357121 gggaatatct gaaacagctg ctgtctttgc gggtgtcgat gtcacccagg agccaattcc 357181 tgtcttgcca actgtccatt ataatatggg aggcattccc acaaaatgga ctggtgaagc 357241 attgaccatt gacgaggaaa ctggagagga taaggtcatc ccaggattga tggcgtgtgg 357301 tgaagctgct tgcgtatcgg ttcatggagc gaacagatta ggcgctaact cactactgga 357361 tttagtcgtt ttcggtcgcg ccgttgcaaa taccattgct gacacattac agcctggctt 357421 gcctcataag ccattggctt caaacatcgg gcacgagtca attgctaatt tggataaagt 357481 aagaaatgct cgcggctcac tgaaaacctc tcaaatcagg ttgaacatgc aaaggacaat 357541 gcaaaaagat gtttctgttt tcaggacgca agacactcta gatgaaggtg ttagaaatat 357601 tactgaagtg gacaagacat ttgaggatgt gcacgtttct gataagtcaa tgatctggaa 357661 ttctgatctc gtagaaactc tggaattgca aaatttactt acttgtgcca cacaaacggc 357721 tgtttctgct tccaaaagaa aggagtctcg tggtgctcat gcgagagagg actatgcaaa 357781 aagagatgat gtgaattgga gaaagcacac attatcatgg caaaagggga catcaacacc 357841 tgtaaaaatc aagtacagga atgtaatcgc acatacttta gatgagaatg aatgcgcccc 357901 agtccctcca gctgtcagat cctattaatt cttatttatt tatttattta ttttggaggg 357961 caaacttatt tattgatctg gcaaaaatga tctttccctt ttttcttatt tttctctcta 358021 tctctctcat tgattcttgg tcaatagtac tcgtttactg tcaacttaca ccttatctat 358081 tatgctatat aattttatgc aagacattga agtacaatat acgtcgagct gcaatatgca 358141 aaaatatcag agggaaacca gctcattagg aaatatgaca tgtgggctat ctgtttgttg 358201 gtggtagctg ggtttttttt tttttttttt tgattttgtc gtgcgggtgt gcaggctggg 358261 atttcaaaca aataacaacg agtaattgac aagaaaaact tattggctta ttttcttttt 358321 gttcttcaaa attgtttgcc ttaccctctc cctcagtttg ttttcgagtg attgtctatt 358381 aggatcaata gtcaactttg ctgtttccat acttaaaaca tcactagtct ttatgccgaa 358441 cttcgcattt ataaaagtgt cgcaaatcaa tctcatatcg tcgtaatttt ttccatacca 358501 caattcacat aaatttccag tgaccttaca caggtctaaa aacttttcat catctttact 358561 ggcatcttcc ttttcaaaaa ttttcttgaa atgcaaaatc aattcaacaa attcatcgtt 358621 attattcgta tgttcatagt caccttggct cactagttcg tgaagctcat cgtaaatgga 358681 taacaaaagg gtgatgatag tgcatgcaat gaaaatatcc aagggataat tgaacgtcag 358741 gacgtggtcc caaacgatta gcacatattt taagggtaat tctcttaaaa ataacaacct 358801 tgtccatcgg atgagccaga ttaggttgga gtgaatcaga tggtctacgt tttttttctt 358861 cccgctgccc gtttttggtg gttggtaaaa aacctttgaa aacaagtctg gcaaacaaat 358921 cctaaagatt ttcgtgaata ctctcttatc ccagttaatc aaattttctt cgttataaaa 358981 aatcggttcg atttggttca ttagcttgtt aaagataatc agaacgtttt gcaaatcggt 359041 attatcgaga tctgtaccgt gatataattg cagataaatg acgcttaata tttcgtggaa 359101 cccttgttta tactgtaggt gttcgctttg atgtataagc aggtaattgt acaaaagttg 359161 tctcatttga gcatgaacct tgggttcctg aaatatatcg tcaagcatta tccttgagag 359221 gtccaaatct ataatttcca gagtttccct cagtgtcaac ggcttttcat cacttccctt 359281 ggacaaagaa cctttagttt tgtcattgtc atcagacaag ggatgttttt caacagcctc 359341 gacgggagtc agcctcctga ttcccactga ggaggaaacg ttcgagtgca agaccctttt 359401 aggtacattt gcattatgat tttcgtcata gttgtcgcca tctgccagca taggcactgg 359461 caccaagccg aactggttaa ggtccaaacc tttaaagtta tcagttaaca agcagttgtt 359521 gttttcatca cacagaagca aagctttcca gagccagcct ctactatttt ctttaaagat 359581 agagtcatgg tagagttcac ctttccaaat tcccttctgc accagttggt ctcttgtctc 359641 gtagtggtca atcgcccatt gtaagacatc cttcatggtt gcataagcga aaaaatacaa 359701 acgcacgaca gctaaccctc tctatgtatg ccaattctct tgacaactct cccccattgt 359761 tctgaaaaag gtaatgaaat taaacgctgc tgtaccgatt atggaaaact caatggaaaa 359821 attgaaaaaa aaaaaaaaag gaactagtaa tgccgtagga gaagcgggta acataatatc 359881 cggttttcct ttacgaccgc ttacaggcct aaaccagcgc accatccagt tacaataaca 359941 cttggagcat gcgtacacgt gtgcgtattc tacggctggc atgggcaaaa taagacgtgg 360001 aatttttctg tggtcagaac tttgcgtcag taaataattc aagaaaaaat aataattatg 360061 tcgaaaaaaa aatagaaaaa aaagaaaaaa agaatactaa aaggtgagtg ttcaggaaaa 360121 ccgcaagcca tgtttgttga ttattccgga ctggagcgtt acacggatat aaatgcatct 360181 tttggtaagt tggtcaacac ttactgctgt tttcagcgct gtgaagccat cagcgaacaa 360241 ttggagattc tgaaaagtct agtaccaaag tgccacgaca ttgtggcact tactgacgaa 360301 gactttgcta gtggccgtac tgccggactg acgcagaaat tgtttgctat ggcgatgacc 360361 ctacaccaga tcaccgactg tatcgacctc ctgcagaaat gcaacaccat aatacccatc 360421 gagatcgcca acccggctag ctttgaaagc ggcgccgcga cggcgccgct acgtcaaagc 360481 tatgctaggc tcttggatga ctggtcccac tacatgggcc catcaacggt aaaacacaca 360541 ggctgtacca accgacccaa gtggagattt ccctggcaac agtcacggac tatcatcatc 360601 cccatgctgt ttattggcga aactgcaatg agcaccaggg acctaaggtc tgtgctgcat 360661 gattgtgaga tcaggcacgc gagcgaaatg ccgctgcagc tactttggac gtcgtcaccg 360721 gagttggtgt acgccacacc gcatgttgac gactacgaca tttggtcgcg ctacgggtct 360781 gattacaaca tgcagataga ggacgaagac gaagcatcaa aagggcgaca gcgcaagtgt 360841 gtggtgcagt tggaggcact gttgggtgcg ctacctacta cggacccgtt gttccaatgg 360901 tagcccgggc cttttttttt ttcatcagct tctcttttag gccgtcggcc ccgttcgatg 360961 ttcacccgtc ctggacagct tgctctcccc ccttcctcgt gctgcgcgac tgtttacgtt 361021 attggcttat tgtattgttt tcgcatctag aacgttcagg ttcaatttac gcaacggtgt 361081 ttcactcgaa gcatctggct gtacaagcaa atgctgcgtt ctcattctcc tttatataac 361141 aagcttctgc cttaaagcgt tcatatgtac atacatatac accactcagg cactcgcata 361201 atcgcactta aatacgcaaa atatacaaga tagccctaca actgctccat ggactccaag 361261 gacacgcaaa agttgcttaa ggagcaccga atcccctgca tcgacgttgg atggttggtc 361321 aggcccagtg cctccaccag caagagctcc agaccaggga aatccgagtc caaggccaac 361381 agtgtggctc ctgacatcca gatggacact gctcgcccgc ccgttttcga aacgtctgta 361441 gactcttcca gcagcattct ttcttcaaac gataagggac gccgtcactc cgtagctgcg 361501 agcttgctaa tggataatca gcgtgctaac gctgggtcta catccgttcc cacaaacatt 361561 cctcccccta ggggtaggtc gaagtcagtg gtggagacta acctgtctaa cgttgaggct 361621 gactccggac atcatcacca ccaccgccac caccatcaca cggaagatgc tcctgcacct 361681 aagaaggtcg gattctttaa gagtctgttt ggccatagga agaaggatca ggaacaacag 361741 gagaaggaac gagaaaggaa agagcgctca ccctctccga ctcacgtgga ccgtggcgcg 361801 gccataagaa gagaaagaac ggctaccata tctgcggaat caccaccgcc tttgcagtac 361861 aatgctccac cctcttataa cgatactgtg gtaccgttaa caagatccaa gacggaatca 361921 gaagtgtatt acgaaaatca tccgcaaagc tactaccatg gccgtatgcg cacataccac 361981 tcaccagaag agggtaaagt cgacggaact tcccccgcag acgatcataa ctatggcggc 362041 tctcgacctg atcctagatt aatggatttc ttgcgctact acaaatctaa ggattacaaa 362101 ttagccgcct tcaaagaagg gaactttatt aagtcatctg cgtctcccac aaccaagaaa 362161 aatagacgcg cttcgttctc attacataac gacaaaccac aacctgccaa atcacttgct 362221 caccagaaat ttgacgctaa gggaagaccc attccgccgc atcccgacgc acccaaattg 362281 ccttccgcct tcaggaagaa gcatccaagc aacgcatcga tagtagacac agtggattcc 362341 aattcggacg tttcctcgtc agcgcagaat aataatcaga caccttcttc tcataaattc 362401 ggcgcctttt taaggaaagt tacctcttat gggaacaaca acaacaacag caccaatgcc 362461 tcctcccttt ctgcaaacgt caataatcca gacacctcat cgacgtccct atggtcttct 362521 agttcaatgg agttcgaccc ttcaaagata accaccgtcc ccggcctcga gaatatacgg 362581 cccttgaaac acgtctcctt tgctacgaac acctatttca acgatcctcc acaacaaata 362641 tgcagtaaaa accctcgtaa aggtgaagtg gaagtgaagc ctaatggatc tgttgtcatt 362701 cataggttga ctccgcaaga acgcaaaaaa atcatggaat cgactagttt gggtgttgtc 362761 gttgggggga ccgggcaatt aaaactatta aatcccgagg aagacgacgc aaatgccaag 362821 agtaaagagg agatggcccc tcaaaagcag aacgaagtgg aggcacacga cgaggaggat 362881 aacaattctc aaaggagaaa catcgttatg gccgctgcag aagctgctgc agaggccaga 362941 gccaaagagg cacctaacga attgaaacgt atcgtgacca acaatgaaga agaagtcact 363001 gtcagtaaga ccgccagcca tttgaccatc gataagccaa tgatttcaag aaggggtgct 363061 tccacatcct ctttggcctc catggtgtcc agtgatacca acggtacgaa cgcagatgat 363121 gaaggagaaa ttcttccccc accttctttg aagatacctc acgacattgt gtatacccgt 363181 tgttgtcact tgcgagaaat tctgcccata ccagccacat tgaagcaatt gaaaaagggc 363241 tcgacggacc ctatccccat cttacagtta cgtaacccaa gaccttctat ggtggaaatt 363301 tggtcgttca gcgatttctt gagcattgct cccgttttat gtctttcgtt ggacggtgta 363361 caattaaccg tgcaaatgct tagaataatt ttgagttcgc tggtttacaa acagcatttc 363421 caaaaacttt ctctaagaaa cacccccttg gatgaagaag gatggaaagt tctgtgttat 363481 tttgtctcca aggccaagtc tctgcactct attgatttga caatggtccc ttccatcaag 363541 acaaatgtac aaaagccttc taaatcttct ttgaagtcaa aaattctgag aatgcaatgc 363601 aacttggaaa atagatccga catgaactgg gaccttttga cagcttctat tgccctcatg 363661 ggcggtttgg aggaaattgt catttccggg gccaagatga attctgcaca attcaaaaac 363721 ttcatcctcg ttgcttgtat agcaaccgag agattgggcc tcgcgtataa tggattatct 363781 aagagccaat gtgatgattt ggccaagtgg atggttcaat caaaagtgac aggtctagac 363841 gttggtttta acgatttgaa tggcaaactt tcctctttca ccgatgctgt tttaggcaaa 363901 atacaaaaag ctaacgagaa aaacgtcttc aaatttttat ctctaaatgg gacaaatttg 363961 agagtgaacg aacacgacac ttttgagaat aacgaggtct taaaactgat aagcgtttta 364021 tgttatttgg aaaatttaaa attcttggat atatcgaaca atcctgccat cttcccccac 364081 tgtgttccga cgctgattga ttttttacct gtttttgtta atcttgtccg tctgcatatc 364141 gactacaata atttaagttc cacgagtgta gtgatgctgg ccgaaatatt acccatgtgt 364201 tcaagattga attatttttc catgttagga acggaattgg atttggcatc gtctaaagct 364261 ctagcagagg cggtgaggaa aagttcatct ttgatgactt tggacgtgga ctatgtgtat 364321 atgccagaga acattaagga aaaaatttca ttatatgctt taagaaatat tcaaggggag 364381 ttgaaaaggg ttaatagtga cgataaagat atcaaagata gccaattttc aagcctacag 364441 gaccaactat cacttttatt aactgaaaaa gcggataatt ccgaacatta caacaaaatg 364501 gttgagaatt tcatggccaa aatcgcgttg gcacgtatca agattagtaa agtggttcat 364561 gatctttttg atttaaaact gaatggacaa ttaaatttgg aaggtaagga agctttgatt 364621 agattatgct tcatagaggc aagtttggaa agaggctgtg acctgctgaa acaaagacat 364681 aacaacactt tgaaatcacc agaggccgtc tcaaaaagtc ggaaaggggg aaatcaagca 364741 caacccaatt ccgaaagctg tcaaagaatg ttactaagct catctatatt acaaaattca 364801 gatcatattg cgcttatgcc attcggtagt gcaatagtcg aaaagtcaag cccagatgca 364861 gaagatgccg tcgaattcag agaaggtgac gactccaacg taaatcacga agacgtacca 364921 gcaaatgatc aacaatttcg agatgaagtt gatatcaaaa acaaatactc tatcattaaa 364981 agagaactag aacacgaaaa gcttgtcggt ggtggcgatt tgccagtgga caaagaaatc 365041 ttaaatcgtg ccgcacaatc cttagatagt gaccagataa aggaatttct gttgaagaat 365101 gacgtctcta ctatccttgg cgtcattgat gaactgcata gccaagggta ccacttgcat 365161 catattttca aaaaacaggg aaaccaagaa gagaccgcgt tcagaacaaa ggatgaacaa 365221 cagtcctccc aatccaatga ttcaagtgct aatgcgtccc ctaccactga tccgatatcc 365281 acaggctcca atacttctag aacgaacgat aatgctcata ttcctccgac cgatgcgcct 365341 ggatttgata aatttatgaa caatgcagag gaaaatgcca ttgacgctgc ttatgatgat 365401 gtgctagaca aaatccagga tgcgcggaac agtagtacta aataataagg gatttctctt 365461 aattttttaa tctctttttt gtattgggtt tcgaaaatat aataaggagc cctcagacat 365521 ttacgtatcc tttcatgtat gattatttta agtattttgt attttttatt attattaatg 365581 taagcataat gcttttgtag aacttgagac aacccggacg ggtccgatga gtttttttct 365641 tcaaactttt atagaaaata ataaatggtg ttagcaccac tcagatgtga tatttgacgt 365701 gtcgattgtg atacctgaag acgctattgg agagccattg caacgcacag tccaacagta 365761 ataagctctg atcgttttga aaaagtatgt ttctttccat tggacggttg tcttccgatc 365821 aaaattttat ctcctataca atttcttcct atttactaac gaaaacctgc gaacctgtaa 365881 actacatgat ttttaatatt agtgaacttc aatacacctc aacaaaacaa aacgcccttt 365941 tcgttcggga ctgccaacaa taactctaac accaccaatc agaattcctc tactggtgcg 366001 ggcgccttcg gaacaggtca atcaacattt ggtttcaaca attctgcgcc aaataacacg 366061 aacaatgcaa actcttcaat cacacctgca tttggtagca ataacactgg taatactgca 366121 ttcggtaaca gtaaccccac aagtaacgtt tttggcagca acaattctac gactaataca 366181 tttggtagta atagtgcagg gacatccctt tttggatctt ccagtgctca acaaacgaag 366241 agcaatggaa ctgctggagg aaatacattt ggttcttcat ccttattcaa taacagtact 366301 aatagcaata cgacaaaacc tgcgttcggc ggtttgaatt ttggcggcgg caataacaca 366361 actcctagct cgaccggtaa tgctaacaca agtaataact tatttggcgc taccgcaaat 366421 gcgaataagc cagccttttc ctttggtgca accactaacg acgataaaaa aacagaacca 366481 gacaagcctg ctttctcctt taattcaagt gtcggtaata agacagacgc tcaagctccc 366541 actacaggat tttcctttgg ttcacaacta ggtggaaaca aaacggttaa cgaggctgca 366601 aagccttccc tttcatttgg ttcaggatca gctggtgcta acccagctgg agcttcgcaa 366661 cccgaaccta caactaatga accagcaaaa ccagccctct cttttggtac tgcaacatcc 366721 gacaataaga caactaacac aaccccaagt ttttcgtttg gtgctaaatc ggatgaaaat 366781 aaagctggtg ctacttctaa gcctgccttc tcattcggtg ctaagccaga agaaaagaag 366841 gatgataatt cctcaaaacc agctttctca tttggtgcca aatcaaatga agacaagcaa 366901 gatggaacgg ctaagccagc attttccttt ggtgccaagc ccgcggagaa gaataacaat 366961 gaaacctcca agccggcatt ctcttttgga gcaaagtctg atgagaaaaa ggatggtgat 367021 gcctctaaac ctgccttctc ttttggcgct aaaccggatg aaaataaagc tagtgctact 367081 tctaagcctg ccttctcatt cggcgctaag ccagaagaaa agaaggatga taattcctca 367141 aaaccagctt tctcatttgg tgccaaatca aatgaagaca agcaagatgg aacggctaag 367201 ccagcatttt cctttggtgc caagcccgcg gaaaagaata acaatgaaac ttccaagccg 367261 gcattctctt ttggagcaaa gtccgatgag aaaaaggatg gcgatgcctc taaacctgcc 367321 ttctcatttg gtgctaaatc ggatgaaaaa aaggacagtg attcttcgaa gcctgccttc 367381 tcatttggta ctaaatcgaa tgaaaaaaag gacagtggtt cttcgaagcc tgccttctca 367441 ttcggtgcta aacccgatga aaagaagaat gatgaagtct ccaagcctgc cttctcattc 367501 ggagcaaagg ctaacgaaaa gaaagaaagt gatgaatcaa aatcagcctt ttcatttggt 367561 tctaagccta caggaaagga ggaaggcgat ggggcgaagg ctgccatttc ctttggtgct 367621 aaacccgaag aacagaaatc cagtgatacg agcaagccag cgtttacttt tggtgctcaa 367681 aaagataatg agaagaaaac agaggaatct tctacgggga agtcaaccgc agatgtcaaa 367741 tcaagtgata gcttgaaatt aaattctaaa ccagtagaat tgaagccagt ttctctcgac 367801 aataaaacac tggacgattt agtaacgaaa tggactaacc aactaacaga atcggcctct 367861 cattttgaac agtataccaa aaaaattaat agttgggatc aggtactagt gaaaggaggt 367921 gaacaaatta gtcagttata ctcagatgct gtgatggcgg aacatagtca aaacaaaata 367981 gatcaatctc tacaatatat cgagaggcaa caggatgaat tagaaaactt cttagacaat 368041 tttgaaacca agacagaggc acttctgtcc gatgttgtgt ctacaagttc aggtgctgcg 368101 gccaacaata atgaccaaaa aagacaacag gcctataaga cagcccagac tttggacgaa 368161 aatttaaact cgttgtcatc caatctttct tctctaatag tagaaatcaa caatgttagt 368221 aatacattca acaaaaccac taacatcgat ataaacaatg aagacgaaaa tattcaacta 368281 atcaaaatct tgaattcaca tttcgacgct ttaaggtcac tagacgataa ctccacctct 368341 ctggaaaaac aaatcaactc gataaagaaa tgatctaaaa gaaaaaattc cctctattct 368401 acacttattt gacataggat gtgctatatt aaataattat atataggtat caaaatgtac 368461 gcgatggttc agaacctgca attaatttaa cacctcaatc atacttgttt ttttcctttt 368521 tcaagaagtt tttgtaatgt gtcgtgccga tctgtaaacg acctggattt ttatttcatt 368581 agacagtaaa tacgcaccaa atcagaacca aagaaaggct tctgtagtgt atgaaactaa 368641 aagccacttt ttgtgatagt ttcttcttag tacttagtac acaaccaaat attttgcaaa 368701 atgaaatcga ttcctaaaag taattcttaa aagtgataat gaatgactta atcgttattt 368761 tgatatcctg ttaatgtgca taacatcaca attagcttca ccatttcgtt taaactttgg 368821 ttattaggat ccgacgaatt tttcttatct tctttttccc tcaaaagatc tcttttgaat 368881 attccgatca ctagcctctt atacgtattc agtaaaccct ttaccgtttg aacaacagct 368941 ttgtttgagc tccccatgct cactaaaaca gctgatatca attggaatat aggaacgatt 369001 aactcaaaca aggaaacacc attagcatct ttgtcaacta gtagcggatt atccaaggtg 369061 acgttaacct ttaagaattt ggaattctga acgtagactt cgtcaaacat aaggtctaga 369121 cccaaatcag gatcaacttt taaaaatgac aattccgcga ttattcggaa tagattattt 369181 tcaattaaag cgctagctcc acctctagtt tcggcaacac gtattaaaaa gaatacagtg 369241 gctttaaaag ctgtcaattc atataacaaa tcatcaatgt ttatgtgctc tgtagtagaa 369301 tttaacaaag catctgtatt tttcagcgaa cgtattatta agagcagtct tgtagttttc 369361 atcagtgaat ccaatataaa attctcttta cttctattag ccagttgaat aagtgaatcc 369421 aatagtaata tacctgtaac cctactagtt ccctcgccat aaacaacatc gttccatatg 369481 atctctacca attttttact tcctagtctc aaatcctgca gaaccttttc ggaccctact 369541 tggtcgctta gaactctact caaataatgg tttgctaata tatagaaatc ggaccttaat 369601 gccacagagg agagtgggga gtttataccc tgaatacatg tcttgaacaa ctgatatagc 369661 ctgccgtcta ccgtgccttt gtcggtaatc aacttacgat cgcggttata tatatcaaat 369721 aggaaaacgg cgagagaaac caattcttct gaaaaagtta tattaaactc aatataatca 369781 ctaatcttcg gaataattgt accaaaaacc tccagaataa agtttgatct tgttgatggt 369841 tccaattttc catcagtaac aatgatttgc accaactgta cccaagagtg cagcacagat 369901 aggttcaact ccaatgcttt gtttcttgat ataatattcg tgaaatggct ttttgctttt 369961 atacactcga catctgcatc cttcaaaaat tgttcttttg acacagtgag actgaaggaa 370021 ttagaatgta agctttcagc acggactctt ttaatcaggc gcataaggtt ttccattttg 370081 tgaaagtcat agatattgcc ggagcaatac ttgttaagag tgacttgttc caaatttaaa 370141 ggaacattgg tgaaaattga taacgtctct tttggttcgc agatattgcc atagtttaat 370201 ggatccaaga aagaaaacaa ccttaccgaa tacattgtat ttgatatcaa gtaattcaca 370261 tatgttaaaa cctctgattt cgtgcccgaa aatgaaattt tatgaatgaa cagacccaaa 370321 tattgtgtcc aataattcct gtaggctaag aatgacagaa atgcaccaac ggattcgctc 370381 tcgatgaagt tcttacattt ttcctctgta gaattgtcaa aaggagagcc gttccatgtc 370441 gtgaaccttg tcacttgtgg atcgaggatc attattctct caaaaaagtt ttctttgatt 370501 aggtatgaat atagtagacc agatgttaac ggattacgac atagtttgag aataatttcc 370561 agtgctgctg tagccaatct cataggtgca taatcgatat tgtccttagt aatgctgttc 370621 aatgaagctt ccaacacgct tatgagggaa tcaagtaatg aggttccgga agatataaat 370681 gttgctaggt taggtcccag ggatataacg tttgagacct ggaaacctaa taacagatga 370741 gaaatagtca tcgttcgact ataattagaa agatttgatg ttaagaaatc taatagttct 370801 aacttcaaag caaggacacc agcgtcggtt attgagcttt ccaattgtgt aataaatgca 370861 tcctttattc tggctgattc atctacggaa tcgaatattg ttaacaactt atttctctta 370921 gacaaagacg caacggagcc attagagcgt tctgaaagtt tcgccaaaat acgcagtgaa 370981 tttgtggcta aaatttgatc atcgaccccg acgtataaac ccaagtgtgc aacaagtgga 371041 atattgaaaa aaattgcatc gtaaaatgaa cgtaatccgt gaagagaata attctttggc 371101 aagaaataat ccgtcttgcc atgcttctta acaattggaa ataattcttc cacgtatgtc 371161 tcctgataat ccaatacttt attgataatt ttcacagcta actgcaacaa ttcagcctga 371221 tttttgccac cttctaactc tatggacaat tgatcaacac caacatcaac tacattaaat 371281 atacttttgt aaatcttttc cgtgaaaata tagttgaata tggggatagc tgggcattct 371341 tgaacgtaat tgaagaaatt ttcgcaatcc accaaagcat ccaaattcgc agctgcagga 371401 atagaattta aaattacact gtaatcaaaa gagcataagc ccgtatagat aattttcaaa 371461 ataggaagct ggacggctct tttatttctg atatcaacaa tttgatccac gtgcgctaaa 371521 atgtcgttga aaatgtagtc aaaatatggc catataccta ccttcctata tccctgacct 371581 aatcttgttg gaaatgccaa tttgccaaaa accatgtatt cactattatt ttcacgagaa 371641 tgaatagaaa tcagattatg gaagagttgt aaaaacccca aaacgtcaga gtattttgtt 371701 aacacgtttg taaaagcatt tctataagat tcggatgaat aattcagcga tgaatccttg 371761 aaaattagag agtctagaaa agaccaaaat tttgttctag aagattcaag ttttggaacc 371821 aagttactta taaccttgaa agcagcgcct acgagaggtg tatttatctt ggtgaattcg 371881 aataggacat ctgagaaaac tttcgatagc gagcttttta catcctcgtc aacctggtat 371941 gtaactgatc caactaaagt taataaagaa gacagaaata ttacagcttc ttcatttaag 372001 ccttcttcta aggctaccgc agtcgaatcg atatcgttat gagttgactc actaaactgc 372061 tgcctcttat ggaggctcga gttaaaattg cttattttct tagtgtagtc actgagacac 372121 tgtgcaatgt ttttccatga aatcgagctg ttttcgccaa aatagtgata gacattcagg 372181 gcattttcag gaccaaagga caagctagaa accatcaaat agaaacaaga cctcatcaag 372241 ttgtcgttgc atctcgaaca ccactcaata aaaccataag cgtttgattc cttatcagac 372301 cagaaagtac atgaatattc gggccttgat gcatagaaaa aatatattga cagaaaaaat 372361 ctttctaagt cagcctttag tgagatgtca tccaaagtta agtcttcacc ggacaacaaa 372421 gagtcttcct cagcatcctt aatctttgta agcaaaaagg cacaatctgt aataatagtt 372481 tgaagcacat catcaaagga tgagaggaaa aattcttggg tctgatcgga taaaactata 372541 gtagtgtaag aatattcgtt gacgttattg ggcatactat ttagtcgagc ggtacccgtg 372601 gttgacatca tcccaggata agacggattc cataagccgc gtccgctcat attatcagtt 372661 gcggatgctg ggttgtaggt agaattcgtc gtttgactga aaattttttc atcatcaagt 372721 aactgtttag gaattagcct tggaatatgc ctttctaaca gggaccttat atcgtagaaa 372781 agttccatac tcttgtcttg ttccacgata gatgtatctg cggcaaatat taaaatttgt 372841 tcaatagcgc ctagttcgac ggcagaagtc attggctcat caacatcagt tttgaaatcc 372901 atcgtgtcag cccttctttt agggtcttct ttacaccacc caatgaagta agcaaaaaaa 372961 atgaaaataa gagctacttt gaccggtttg gtatatatgg agtcgtcctt taagtctttc 373021 ataaactgag aatgtaataa tttgacatct gcatcgggca aaactcttaa agatgcgaaa 373081 aggtggaaaa atgcaggagt ataatatatt ataaaaaaat cattggaatc caattctgac 373141 acatgatgaa gtaaggacag tataaaatcc ttatttttca tgatggctcc tttatccact 373201 aaaccatata aaatttgact cagaatatca tattctctca gtaagaagtc tctcctaaac 373261 ttgatatttt gttggaataa agcattatag ttttctagta tctgagcctt attgatttgt 373321 tgtttaatct cagataattg agtatgaatg aacttaaagg ctgagaggat attagaaact 373381 aaagctccat tctttataag ctcttggtat aactcagtat cttcgtggaa acagttgact 373441 ataaaagaaa caatttgcag gatatattgc cttctcaaaa agtattgtac tttgccatta 373501 ttagcggtgg tatcaccaga aagtataagt tcacatgcaa caatttcatc caagtttaat 373561 tcatcggaca aagaaatagc ttcgaaaata aactcctgat tgaccttaaa agtagagcca 373621 tcggatagtt caatttcacc tttttctaat tgtgatcggc tagcattgtt ttttagtttg 373681 tctgtgttta agttcaaatt ttgtaagtca ggaagtacct ctttgaacag atcaaaatcg 373741 aactcaccac tctcaataga gcgatacaat gtttggaaag gaattgcaga ccatttcatt 373801 ttttcttatc tgcggaacaa atcttttcaa ctaggttaga tgccaagtga tataagttat 373861 atatatttcg tgcttaggag gcgtgttgtt aattggcgta ccctgaggaa ataatttatt 373921 aagtatagtg taaactaagt ggctaagaaa ggtattggta aactagttga aaggcaatgg 373981 gcgcatttac taaatactac atcacactta caaactaacc ttgttatttt ccagcagaaa 374041 atttattttc atcaaaagac gaaaacggaa tcatactacc cggcccgaga aggactttga 374101 tgaagaccgt agttagaatg ggctcactag actcgtgagc cgtttcagtt taattattat 374161 tatatatgta taccagtgct ttacccaaaa gagaatattt acgtgaaata ctacgctctt 374221 gctgggacct taacgtgtat atactatcat aaactgagac tcttcgtaaa ttgcccctta 374281 acaacacggt gctgtgaatg ctatcacttg attatacgcc aataaacttc atattctttg 374341 aagagccgct gctattgcat ttaatgctaa ggaaggttaa caaagcatta atgaagaata 374401 actacaggag tagccaaaaa aatctccgcg acggggaatt gaaccccgat ctggcacgcg 374461 acaagcgccc attctgacca ttaaactatc acggaagaaa caaagcactc acgatggggg 374521 tcgaacccat aatcttctga ttagaagtca gacgcgttgc cattacgcca cgcgagctac 374581 tatttgttga aggttttact actttattat agtaaaacct aattacgctt tcaattacta 374641 caattttcgg attttcacgg ctggtgaaat aatgcagcct gtattgcata aaatggccgc 374701 acttatgaga actgatacaa gttgtttacc gttggggcac caaggtgtta ttagtcagaa 374761 ataaatgtaa atttcttata ctgcaaagca gaggtacata taacacacat cgattggttc 374821 atcttggcta cgactaatat ttttgggatg caggtgaata attagataat tgttgtaatt 374881 ccattgttat taaaggctat aatattaaag gttatttggg tctttctctc tctcggcttt 374941 attttattta tagtttctat ctttcagctt tcaaaaaata atatatatgg cgcttcatga 375001 aaagagagct agctacagaa atataaacag tcatggatga ataggcggcg gcagctatgc 375061 cggtgcatgc gcacagtata atggacttaa actgccttag tacaactgtt caagttattg 375121 aatagcatta tatattagtg ccaaccaaaa tatgaaaccg atgcttccaa ctgtcacccc 375181 aagaagacac gcaaaaggtg ctactgcaca taaatcggcc actccttgag ctagacccaa 375241 ttctaacaga cttacagtta ggattctctt tattctgtct agtcgtttct ttttttccct 375301 cgcttctttt tctttttcgt cttctctacc accatttata gtaattcgat tctgttctct 375361 actgaggttt tctaaagcat taactacctt gcccctggag acttctttaa actttttgat 375421 atattcaaat ggtgaaacat tcaaagccgc atctagtgcc ttttccacct tttcatattc 375481 tatttcgagc gactctctct cattattatc caaacttttc actttataat ttagcaccgc 375541 ttctaagccc ttcaaaataa aagtatgctg ctcatatttt gcactaatgt tttgaatttg 375601 tccctcgata ataggcacct tctctgctgt caatgtttcg tatgttccat tgttgtccag 375661 atttctcaat gatgtgatta acctatcgcc cgcatcgctg aactgttgta ttgtgttagt 375721 tcctgcaatc acaacaatgg tgaaataaaa atatatgaaa agctggaacc tcatttgaat 375781 tagtttactt cactaggctc ttttatcttc acttattgtt ttgtggtgtc tatttttttt 375841 actgacagtt tacactttta tagtctttaa aaaagcaaaa aaaataattc ttttattttt 375901 atcccaagat aataaatatt tatgtattgg atagtagtat aattgagtat aaaaattatt 375961 tttgtagtac tttttcaaac taatctctgc aagacatatc ttccatattt tcacaattat 376021 ttaagccgat tgcaacaaca ttcaccatag gtgccttttc tgcggcaatg cgtagcccta 376081 taattagctg cttgaatgag aaaaccacaa aaagggggat tgaatacata gcatagctta 376141 cactgtatct tagtaatttt tttcccttct actttgtttt tcgcagggcc tttgcctttg 376201 gaaaagggta cacgagtctt aagagaaatg aaaaaaaatg acactaaatc ggtgataata 376261 atttgtcgtt gtgaccacaa aaaagaattc ataaaaaaaa aaacttgatc attggcgcca 376321 caacctagtc atatttgaaa tcattttttt cctttatttt ttaccacagg gtgcgtttag 376381 aagagacaca aaatcactct agggttttct atcgaacata aagtaaatca tttttatatt 376441 ccaaaattgc tcgaagtaaa tctcttgttt tcctcccaaa tgaagatcaa tattaaacct 376501 ttctgaaaat cttttttaat acagattaca ttatagagtt gtatactctt cgatcattta 376561 acttctcttt tatgggtcat atatctctaa ttgtctctac agtacttttt ttgcttttcc 376621 aataaaaatc ataatcacag ccatagtcac aaaactataa gatgaaagta caaatgatag 376681 aaaggatttt tctgatccag ttgtgtttgc ttaccgttgt attagcaagt agtagagcag 376741 tggttgaatt cgaaagtacc ggaaccaaac tggtcaactc attaagggtc ttggctgctt 376801 actcgcagag ttctgtctgt gttgatgaaa aaatatctgg aatcgagaga caaatagagg 376861 aagttaaaga tatgtatggt aaccactctt ttattctaaa gggtttaaat ggtatattga 376921 ataacaaggt gaatatgcta acaagggaaa tccaaatgga aactgttggc aataacacat 376981 ttgaaacaga aacagggaag ctaactaagg gcctaaaccg agcagtaaat atatctccgt 377041 tcaagtacat aaaaaaattc aagaccgttt caacaaagaa atttgaaagc ctcttgaata 377101 agtatgatct ggttgccaag aagggcgggg aattgacaga ggaacaaaag aaaaagaagg 377161 aggtgctctc acggatcagt agagtagtcg ctgcaacaac gatagaggct ggtctggcac 377221 aaggtgtggt tgatttatgt ataacagtga caactagtct atgcttagtc tcggccagca 377281 ttggaggcgt cggatttctt atttggctca ccattatata ccaagctctg acttaggaaa 377341 atgttgccga ttttgttttt gccactcctg tacattgttt aatctcagat cgttgtatat 377401 atatacatat atatagtgtt ttaacgacat tcttatattt gcatttctgc ttcttattac 377461 acctaactat tctgtaactg ccatgggtaa gcatttttga agtattaatt aacaattaaa 377521 ctttcaaaca tacccaccct ttcgttggaa taaaaatcaa ttaacaccca ctgactagta 377581 aatattacta gaataactga tgattatgcc aattttctga cagttgttgg gtttccattg 377641 ttgacgaagg tcctattatt agatatacgg aacatactag atctctcgag cctatcggaa 377701 cctactaagc ggaatcggca atatacatgt tattcatttt tttcgttttt cgttttacat 377761 tattaatttt acgtctcaac ttggttcaat ttcagagaca gcatctcatc acatctatca 377821 tctttttgta ccacataagg taatatacac gtaataatag gcaatagatg tgtgcgaatg 377881 aacttccaat ataatccatt tagtagtgcc ttttgttact aatattcgtc agtttctcaa 377941 gctgacactt gatttattct aaacaaattt caatcttgga caattagttg acataaacta 378001 cgttactaat ttttgttgta ttaagggctt aaataatacc ggatgtcttg gcaattctat 378061 cgttaggaga gtaatagttg tcagacttat tgtcggcttg ttcgcacatc gttacttatc 378121 ctatattata cataagatct ggtgaagcga ggagtcccat gtctaaaccg attgctcagg 378181 tatttacagg tttaactgct tcatttaagc aagcaattat tgaattatat actcaatctt 378241 gtctctcccg ttactattat ttcattcgcg ttttatacat ctttattatt ataagtttga 378301 tacggtaact ttacaatcga ttaatttctg ctgaaagccc aagctttcat aaattaatag 378361 gtttcgtggt ctagtcggtt atggcatctg cttaacacgc agaacgtccc cagttcgatc 378421 ctgggcgaaa tcaatttttt gtttttttaa ttcacaagaa taacctggta ttgttataag 378481 caagccaccc tttgcgtacg atcaaacacc ctataaaatc tatatgcaat actgagatat 378541 tgtatttttt ctcctttaat tgtttatagt tcagaataac agttcaaaaa tctatgccgc 378601 gctcacaggg tcctgccggg tattcgccct ccagcttgaa aggggtggca atgcccaaga 378661 gcgatgtata gtttagtatc aaggaattga gagaggtatt acaccaagga tttccgtgaa 378721 cgaagtgacg acgcaagatt aacagattaa attctggtag taggctaagc cgttattaaa 378781 ctttatttac ggtataccac aatactgctc tttttgttga ggatatgaca gacaaaggca 378841 agaacgattt aacaagcaaa gctaaggaca aagccagagg caaccccgag aagccaccat 378901 attggtttga aatcattgtt tctgatccac aaaaaagaac tggtgaccca ggctcttcat 378961 ctggctacgt gagttatcag atatcaacaa agactaacaa cacgtcattt tatgataatc 379021 gtggcgatcc agaatctatt atagttgtac atagaagata cagtgaccta ttgctcctgc 379081 atgatatttt actcaacagg ttccccacct gcatcatccc gccattacct gataagaaag 379141 tttttcaata catagcaggc gataggttta gccaaagatt tacacaaaag agatgtcata 379201 gtttgcaaaa tttcctaaga agggtctctt tgcatcccga tctttctcaa tcaaaagtct 379261 tcaaaacttt tttggtgagt aaagattggg aatctcaccg caaagtcctc caggatagct 379321 tgcaaccaaa taaagatgaa gttactgatg cttttatgaa tgccttcaaa acagttcaca 379381 agcaaaacga agaattcact gagataaggg agaaaagtga taaactagat cggactgtga 379441 caaagataga taaacttttt cataaggttg tgaaaaaaaa tgattcgatg tctgaagact 379501 atacaaagtt gggcagtaat ttacaggaat tacaagaatt ggtcacaggc gaaaacgagg 379561 aacttgctgc gaagttgaag atttttaatg aaggtgtaac acagctgtca tatggcttgc 379621 aagatcttac aaagtatctg gattacgaat atattgttga tttgaaggat cttgaacact 379681 acattgatag tatgcgacag ctgatcaaat tgaaagacca gaaacagata gactacgaag 379741 aactaagtga ttatttaacc aggtcaatca aagaaaaaaa taacttgatt tctggatacg 379801 gaggtagtaa tttctttgcc aataaattgg aagaactagc gggaataaat caggaggctt 379861 cacgtagaga aaaaatcaat aaactagaag gcaaaataac gtcattaaca ggtgaattag 379921 aaaacgctaa aaaggtggcg gatggattcg aacaggaatg cttgaaggaa atagaccatt 379981 tcgaaagtgt aaaaacggct gaaatcaaga aatctctggg ctcactagcg gaccatcata 380041 tcgaattcta cgaaaggata cttgaagcat gggaaaaagt agacgatagt ctatagtggt 380101 gctcttaatg ttttcccatt actactgata ataccttggg cactacgatt atctgatcac 380161 atttaacaga gaaatttaaa aaaagaaaaa tatctatata aaaatatgta aatgttgcta 380221 ttattttatg atgttctgat ttttttcgtc aaaccttaga tttcttatgt acattaaact 380281 taaacatttt gcattgttct tccagttctt ggattatatt atcttggtgg gagtcaatca 380341 aatcccaatc gacgctatta ctggacaagt caactttatt cgcaaaacaa gtcctgtaat 380401 catcaccaaa agtctcaatg aatgcttctt cattaagata ctttgaccat tccataggcg 380461 gaaacgtgtt tttatccaac actctgtcac tcttggaccg tggctttggc gccctttcat 380521 tttgtcttac ataaaagtat ctcagcagca ttattgcttc tttcctcaag atccccggta 380581 tactctcgta ccctgccgca ctattgttct tgggcactaa tgtacacgta tcatgattta 380641 ctgacaagac agtaccgttg cctccaaatc tctcgttgcc acaaccgaac accacctttc 380701 caatgtctaa ttgcttgaga gcagatgcac acattataca cggttctaca gtaacatata 380761 gagtaatgtc tttgaacacg tcaacaactc ctcgggagcc caacatcgcc ttgatctgat 380821 cgatccccat gaactcagca tgtgctactc cagttaatga cttgttcgta tcgttcatgc 380881 cataagccat cacctggcca gttggcgtat gtacaaagat gcaagctacc ggtgtctcat 380941 cgtggtcaag agcgtatcta gccaaacgga cagctgtcct catatgttta atatgctgca 381001 tagtgtgagt cctctagttt ttaccgcagc caccagccgc ttctcgagca aagtgtagat 381061 cccattagga ctcatcattc atctaatttt gctatgttag ctgcaacttt ctattttaat 381121 agaaccttct ggaaatttca cccggcgcgg cacccgagga actggacagc gtgtcgaaaa 381181 agttgctttt ttatataaag gacacgaaaa gggttctctg gaagatataa atatggctat 381241 gtaattctaa agattaacgt gttactgttt tactttttta aagtccccaa gagtagtctc 381301 aagggaaaaa gcgtatcaaa cataccatgt ttttcaacag actaagcgct ggcaagctgc 381361 tggtaccact ctccgtggtc ctgtacgccc ttttcgtggt aatattacct ttacagaatt 381421 ctttccactc ctccaatgtt ttagttagag gtgccgatga tgtagaaaac tacggaactg 381481 ttatcggtat tgacttaggt actacttatt cctgtgttgc tgtgatgaaa aatggtaaga 381541 ctgaaattct tgctaatgag caaggtaaca gaatcacccc atcttacgtg gcattcaccg 381601 atgatgaaag attgattggt gatgctgcaa agaaccaagt tgctgccaat cctcaaaaca 381661 ccatcttcga cattaagaga ttgatcggtt tgaaatataa cgacagatct gttcagaagg 381721 atatcaagca cttgccattt aatgtggtta ataaagatgg gaagcccgct gtagaagtaa 381781 gtgtcaaagg agaaaagaag gtttttactc cagaagaaat ttctggtatg atcttgggta 381841 agatgaaaca aattgccgaa gattatttag gcactaaggt tacccatgct gtcgttactg 381901 ttcctgctta tttcaatgac gcgcaaagac aagccaccaa ggatgctggt accatcgctg 381961 gtttgaacgt tttgagaatt gttaatgaac caaccgcagc cgccattgcc tacggtttgg 382021 ataaatctga taaggaacat caaattattg tttatgattt gggtggtggt actttcgatg 382081 tctctctatt gtctattgaa aacggtgttt tcgaagtcca agccacttct ggtgatactc 382141 atttaggtgg tgaagatttt gactataaga tcgttcgtca attgataaaa gctttcaaga 382201 agaagcatgg tattgatgtg tctgacaaca acaaggccct agctaaattg aagagagaag 382261 ctgaaaaggc taaacgtgcc ttgtccagcc aaatgtccac ccgtattgaa attgactcct 382321 tcgttgatgg tatcgactta agtgaaacct tgaccagagc taagtttgag gaattaaacc 382381 tagatctatt caagaagacc ttgaagcctg tcgagaaggt tttgcaagat tctggtttgg 382441 aaaagaagga tgttgatgat atcgttttgg ttggtggttc tactagaatt ccaaaggtcc 382501 aacaattgtt agaatcatac tttgatggta agaaggcctc caagggtatt aacccagatg 382561 aagctgttgc atacggtgca gccgttcaag ctggtgtctt atccggtgaa gaaggtgtcg 382621 aagatattgt tttattggat gtcaacgctt tgactcttgg tattgaaacc actggtggtg 382681 tcatgactcc attaattaag agaaatactg ctattcctac aaagaaatcc caaattttct 382741 ctactgccgt tgacaaccaa ccaaccgtta tgatcaaggt atacgagggt gaaagagcca 382801 tgtctaagga caacaatcta ttaggtaagt ttgaattaac cggcattcca ccagcaccaa 382861 gaggtgtacc tcaaattgaa gtcacatttg cacttgacgc taatggtatt ctgaaggtgt 382921 ctgccacaga taagggaact ggtaaatccg aatctatcac catcactaac gataaaggta 382981 gattaaccca agaagagatt gatagaatgg ttgaagaggc tgaaaaattc gcttctgaag 383041 acgcttctat caaggccaag gttgaatcta gaaacaaatt agaaaactac gctcactctt 383101 tgaaaaacca agttaatggt gacctaggtg aaaaattgga agaagaagac aaggaaacct 383161 tattagatgc tgctaacgat gttttagaat ggttagatga taactttgaa accgccattg 383221 ctgaagactt tgatgaaaag ttcgaatctt tgtccaaggt cgcttatcca attacttcta 383281 agttgtacgg aggtgctgat ggttctggtg ccgctgatta tgacgacgaa gatgaagatg 383341 acgatggtga ttatttcgaa cacgacgaat tgtagataaa atagttaaaa atttttgctg 383401 ctggaagctt caaggttgtt aatttattga cttgcataga atatctacat ttcttctaaa 383461 aatacatgca tagctaattc aaacttcgag cttcatacaa ttttcgagga gattatactg 383521 agtatatacg taaatatatg cattatatgt tataaaatta gaaagatata gaaatttcat 383581 tgaagagtat agagactggg gttaaggtac tcagtaacag tgtcatcaat atgctaattt 383641 tgcgtattac ttagctctat tgcgcaaatg caattttttc ttaccctgat aatgctttat 383701 ttcccgttcc gaaaattttt cactgaaaaa aaagtgctta agctcatctc atctcatctc 383761 atcccatcac tattgaaata ttttgctaaa acattataac agagagagtt gaaaggctcg 383821 agaacctaat actgaaatgg ccaaaaaaaa tagattgaac acaactcaaa gaaagacttt 383881 acgtcaaaag gaagatgagt acatcgaaaa cttgaaaacc aaaattgatg agtatgaccc 383941 taagataacc aaggccaagt ttttcaaaga tctccccatt agcgatccca cattaaaagg 384001 tttaagagaa tcatccttta taaaacttac tgagatccaa gccgattcta ttcccgtgtc 384061 cctgcaaggt catgatgtat tggcggccgc aaagacaggt tccggtaaga cattagcatt 384121 tttagttcca gtaattgaaa agctataccg cgaaaaatgg accgaattcg atgggttagg 384181 tgcccttatc atatctccaa caagagagtt ggctatgcaa atatatgagg ttttgacgaa 384241 aataggtagt cacacttcat tttcagctgg gttagttatc ggtggtaaag atgttaaatt 384301 cgaactagaa aggatatcaa ggattaacat tcttatcggt acacctggtc gtattttaca 384361 acatttagat caagccgtag gtctaaatac ttccaatttg cagatgcttg ttcttgacga 384421 agctgataga tgtttagaca tggggtttaa aaaaactctg gatgccatcg taagcacatt 384481 gtcaccatct agacaaacac ttttattttc agcgactcaa tcacaatctg ttgcagactt 384541 ggctaggctt tccttgacag attataaaac cgttggtaca catgatgtga tggatgggtc 384601 ggttaacaaa gaagcatcta ctccagaaac tttgcaacaa ttctacattg aagttccttt 384661 ggcagataaa ttggatatcc ttttcagttt tataaaatca catttaaaat gcaaaatgat 384721 cgttttctta tcaagttcca aacaagtgca ttttgtctat gagacattta ggaagatgca 384781 gcctggtatt tctttaatgc atttacacgg tagacagaaa caacgtgcta ggacagaaac 384841 tttggacaaa ttcaatcgtg ctcaacaggt gtgtcttttt gctaccgatg tcgttgctag 384901 aggtattgac tttcctgcag tcgattgggt tgttcaagtg gattgtccag aggacgttga 384961 tacatatatc cacagagtcg gtagatgtgc tcgttacggt aaaaagggta aatctttaat 385021 catgttgact ccacaagagc aggaagcgtt cctaaaaaga cttaacgcta gaaagatcga 385081 accaggcaaa cttaatataa aacagtcaaa aaagaaatcc attaaaccac aattgcagtc 385141 attattattc aaggatccag aactaaaata tctaggacaa aaggctttta tatcgtacgt 385201 gagatctata tatgtgcaaa aggacaaaca agttttcaaa ttcgatgagt taccaacaga 385261 agaattcgct tattctcttg gtttaccagg ggccccaaaa atcaaaatga agggtatgaa 385321 gaccattgag caggccaaag aaagaaagaa tgctccaaga cagctagctt tcttatcaaa 385381 agcaaatgaa gatggtgaag taattgaaga taagtcgaaa caaccaagaa caaaatatga 385441 taaaatgttt gaacgtaaaa atcaaaccat cttaagtgaa cactatttga atataacgaa 385501 ggctcaagca caagaagacg aggatgacga tttcatttct gtcaagcgta aagatcatga 385561 aataaatgaa gctgagttac cagctctaac tcttccaact tcaaggcgag cacagaagaa 385621 agcgctttca aagaaggcat ctctggcctc caagggtaac gctagcaaat taatatttga 385681 tgatgaaggc gaagcccatc cagtttatga acttgaagat gaagaagaat ttcataagag 385741 aggtgatgcg gaggtacaaa agacagaatt tttaactaaa gaatctgcag taatggcaga 385801 cattgacaat attgataagc aggtggctaa agaaaaaaaa caagagaaga agagaaaaag 385861 actagaagcc atgagaaggg aaatggaggc tgctatggaa gaagaaattt ctggagatga 385921 agaagaaggg aagacagtag catatttagg aacaggaaac ttgagcgatg atatgagcga 385981 cggtgatatg cctgactcgg aaggccactt gaaaaagaaa gctagaactg ttgactattc 386041 ccacggccac aatccatcca attcagttga tgatgacatt attgaagtgg aagaaccaca 386101 aactttggag gatttggaat ctttgacagc taaattaatc cagggttaaa ccctcctgca 386161 tagtctaacc tatagtattt agaacttgta tacatctatt ctctacacta atatacttat 386221 ttctttgttc aaatcatcgg taatattaca ataaaagaaa aatatgcata tactttcgtg 386281 cattgaaggt gtcaaatgaa atcccgctta tagtgaacag gcttccatca tatatacata 386341 tatatatatg tttatatatg tatatcatca cttatgctgc tccaggagat gtaggtatct 386401 attctttctt aacggatccg catctattaa ttggaccaaa tattgttccg agcttctttc 386461 cgttagagct tccttttctt ccagaatatc ttcgagaact aataaaattt tcaagcacca 386521 aatattttgc ttcccggaaa attcaatttc gtcattattt attaacagaa tgttttctct 386581 caagtctttc aacattttaa ggtactcttg ttcgtccaga gttttacaaa caatgtcgtt 386641 tttaatgaac cacttgatat aaaaccatac ggattggtct tcggcgtcgg taaacatagc 386701 gttgatgata taagatattt cagtccgaat atactccttt tgattcccaa cctctccttt 386761 ctgaaacatt ctgcttatga tctgtactct ttggtgccat gcagaataat ttgaaatgtt 386821 attgttaatc tttattgttg tgtattcaaa ctcctccttg tcaagacttt tattagtgat 386881 actctctatg ttaccaacaa ctattctgcg gtaatgccat ccgtggtaat ttcttgcatc 386941 ttgttccaat aacttattca cgacagcaag ttcagtttgc cacactttag gggaactcgt 387001 aggataatgt ttcaagaccc aaagtctgtg attccatatc caatagactt tggggtaatc 387061 cttcaatagc atcattacaa aaactaactc tttatcccag aaaggtattt ccaactcaga 387121 agccaaactc gctataatat cccttctgta attccaaata gcattaaatt ccggattttt 387181 ctcaagaagt tctgatgttt tcttcagagc ttcaattgag taaatttttt catctctcat 387241 attcaaaaca ttttcagtca agcttctata atcatatatt ttcttttcgt cttgaactct 387301 cttttgtctc agtaattcct tggtccactg tttcctttta atgccatgct gtttaatgtg 387361 gcaaatataa aaaattgctt ggtagtcagt aaaaaaaaga attcataatg taacgaacat 387421 ttgaagtgca cataccattg ctgacctact gctttatagt ataaattcag tatactaggt 387481 atatgtggct caaaaatgtg gtttttttct tttttgcctt taattttttt caaatgttta 387541 cgtatggttt atgatttaac atttcaagaa tagaaatcgc cccgaagaat gattgatgtt 387601 aaatactcgt acaagagtat tgaaaaccac ttcaaagggg cccaatagca catttaatgt 387661 cacaatcaat atcactaaag ggttcaacaa ggacagttac agaatttttc gagtacagca 387721 ttaattccat tttgtaccaa agaggcgtat acccagcaga agatttcgta acggtgaaaa 387781 agtacgatct tacgttacta aagacacatg atgatgaact gaaagattac attcggaaaa 387841 ttcttctaca agttcacagg tggcttcttg gtggaaaatg caatcaatta gtattatgta 387901 ttgtagacaa ggatgaggga gaggtggtgg aaagatggtc cttcaatgtg caacacattt 387961 ctggcaatag caacgggcag gatgatgttg tagatttaaa tacaacacaa tcacaaatca 388021 gagctttaat caggcaaatc acctcaagcg ttacctttct gcccgaacta acaaaagaag 388081 gtgggtacac attcacagta cttgcatata cagacgcgga tgctaaagtt ccgttagaat 388141 gggccgactc caatagtaaa gagatacctg atggtgaagt agttcaattc aaaacattct 388201 ctaccaacga tcataaagtt ggtgcgcagg tcagctataa atattaatag aattcaagtc 388261 aaaaaaaaaa aaaaagacgg aagtccaaaa aaatctcgtt ttcgatgttt agaaagaata 388321 tagatttatg aactatatta tactatacta cgtacttcct ctgtaaacca cttcatgcgt 388381 tttttcaagt gcctctgtta aagaaccttg agtgagaaac gaagtctttg acactcaaac 388441 tttgcttttt ttgttcttct ttttgttgtt gtatttgagg ggtggatact atcctcttca 388501 taacaggtgg tgatattttc agatcttgcc tcacaaattt tgaccaattc ggatcttgca 388561 tccttgccaa gttgttttca aattgaccca aaagtacctt gtcccacttg aatatgaaaa 388621 gatcgcgatt actgtctggc ctgctgccct cgtcagtgtc gtctgtttct aagttgtagg 388681 cactccatag ctttttccat aatgccaggt cccatggaat gccctttaaa gcgaggacaa 388741 aagaccatac cgctgaatca gggttattat tggtcaattt ggagtaggtc tcgtaatagt 388801 catcagcgga atccagagga gccattagaa gtttaataaa cttcagcagc tggtctatat 388861 tattgtctgc atgtcttttc accctcttat aagaggtatt ttctcgcaag tcagaatcgt 388921 tacttacact ttctggtaaa gtgtgaaaaa tctccttcag caattctaaa tcaaggagaa 388981 gctgctcgcc aatgttgaca acagttctgg tttcaaattt ccttttgctg cccgccaggg 389041 aaaagggtgg aacgggctgc agaaggcgga tggtattgct tacaaaattt gtagtgatga 389101 tatcaatcac cttatccaag aaattccact tataaacatc tctattgaat tgcgacaaaa 389161 taaatgccaa agtcgaaggt tgctcttgct gttgtttaat agaggcatct gttaatgcgg 389221 gcattttaag tacggatttg agggttacca tgtacctgct ataatcttct atcgcagcat 389281 ttgaccaatc attgttgata aactctctcc atacaaaatt tagatctaag ggtatgacac 389341 ggtttaatag aaaagaagtt ccttttgcta gtaaatcgtc gtatatattt ttcgttttcg 389401 taaaactgtt tgccagcttt tcacgattac cgctgaattc agataattta tcctccaatt 389461 gatctatagt cgtggcacaa taatctgcag tattgatcaa taaaacggta tacttggcag 389521 cttctagctt atcctggact tcaatattgt cgggcagcag taaaggaaga agaatttttt 389581 gtgagtaagt ttgaagccat ctactgaaaa aatttgccaa tgaagtcaat atgctatcat 389641 tggcattatt atcaatgagc tctaaggtct gagtcagtac ggaacgatat gtcctgaaaa 389701 ggtctgcact cgagggtaac acgagagatt ctgtttcatt agatgggtac ttcggctcac 389761 tcatataaga aagaaatttc ttttccatca tttggttttg gtgagacacc cataaagtca 389821 aataaggttc gaagcaggaa cttagttttg gttccttaat tttttttgaa aatcgtacgt 389881 cgatgtattt ttcgaaatct agcgtcgatt gtaatgctgt catgaataga tcaatggaag 389941 ggttcttgtc tttgaattcc cttttcagaa gtgtctgaag gtccttgtgt gtaatgtgat 390001 aaaaagtggt ggtcaatctg actgccattt cccagtcttt taagaaatag tctgcgaact 390061 ttgaattgaa gttattaaga atttttttga agtaaatgta tcttctcgat aaattttcta 390121 gggatccggc ttcatcgtcg accctaaata tctctttcat ttcgaagaga agtttgtcca 390181 aacaccaatc tatcatctgg gctctcgtac ttgtatcgca gtcgagtagc tcgcaggcac 390241 cttcgcgcaa ttccatagtg agtgctgtat catgctctga gatattgccg ccggaaaaga 390301 gcgcattgta gttttgttta attttggaca aagtgtctcc tttcagtctt gaaatggagc 390361 tcaacaaata gtttatctcg tccaatgatt tgtaagagat gaatgtgttt tcagcaagcg 390421 aacacattat cttataaggg gacaccattt ttttgaatga gccctgtgag agtaattcat 390481 tgcattgtat gtaactgtct gtcaatatct ttaaattttg gaaaagagtc aaagagtggg 390541 tgaggttttt cttggcaatg tccaggtacg agataccttc tgtcagattc gatatcgtca 390601 actcggtgga ggctgagaca tcttgagttt ctttgaaatc ttggaaaact ttcctcagag 390661 aagcctctat ttcagcggaa tttttagggt gttccttcaa ttcattctct tctttgagaa 390721 tatcctcttg caattgcttt ttgtagcttc tggtaatact gatcagttca tctatgttgt 390781 tcagggattc ttttgaaaaa agtatattgg taatatcttc cagcgggtca taatctaccg 390841 taccttccag cattgtcctt ctgagaaaac aaaaatggaa gatgttgtga aaatgcagta 390901 agtgacaata agctagcgac ttttcaatga tcgcagatta agtatatata cactttaggt 390961 ctccttctct tctttactag ctacgaaaaa acaaagaaaa aaaaaacaaa atagagggaa 391021 aaaagatata cgtataaaaa tatgctccag gggaggttcg aactctcgac cttcagatta 391081 tgagactgac gctcttccta ctgagctact gaagcactat ttcttgttcc aaccgaggaa 391141 taatactaga cctgtagaaa agtaccgctt atctaatatc caactttttc ttctgttccc 391201 tttagtgaat tcaagatgaa ggaacataac agaacggaaa acaaaaaaaa agggaagaaa 391261 aaagatatca ccaccaattg gcacgctcgc aacggtttcg ggccagattc atggccctgt 391321 ggggtagaag tgcctacaga caaaaaaccg ttacgtcccg cctcaccaag catcgacaca 391381 caagccctct caacctcctt aatttcttta tctttttttc ccttcacctc tgtgctcttt 391441 ttttagccac agctgtgcat tacgcttgct ttgcttgttt tgttctcttt cgccatgcca 391501 tattactact tttctactta ctggcacgag gccgcgcaag ccagatccaa gcacgccaga 391561 aagtgcggtg tactggtgca accttttatc gatttctcat catatcgcta tcgcaacggg 391621 catgggcgac gaaaaagcca atctaaagcg ttgtcttcct cgttcctcgc gcacgcgatt 391681 ttgcgttctg cataggaagc cgaagtcgaa caagaagcag gcaaagttta gagcactgcc 391741 cctccgcact caaaaaagaa aaaactagga ggaaaataaa attctcaacc acacaaacac 391801 ataaacacat acaaatacaa atacaagctt atttacttga catcgcgcga tcttccacta 391861 ttcagcgccg tccgccctct ctcgtgtttt ttgtttacgc gacaactatg cgaaatccgg 391921 agcaacgggc aaccgtttgg ggaaagacca cacccacgcg cgatcgccat ggcaacgagg 391981 tcgcacacgc cccacaccca gacctccctg cgagcgggca tgggtacaat gtccccgttg 392041 ccacagagac cacttcgtag cacagcgcag agcgtagcgt gttgttgctg ctgacaaaag 392101 aaaatttttc ttagcaaagc aaaggagggg aagcacgggc agatagcacc gtaccatacc 392161 cttggaaact cgaaatgaac gaagcaggaa atgagagaat gagagttttg taggtatata 392221 tagcggtagt gtttgcgcgt taccatcatc ttctggatct atctattgtt cttttcctca 392281 tcactttccc ctttttcgct cttcttcttg tcttttattt ctttcttttt tttaattgtt 392341 ccctcgattg gctatctacc aaagaatcca aacttaatac acgtatttat ttgtccaatt 392401 accatgccta aagagacccc ttccaaagct gctgccgatg cattgtccga cttggaaatc 392461 aaagattcca agtccaacct taacaaggaa ttggagacat tgagagagga aaacagagta 392521 aagtcagaca tgcttaagga gaaattgagc aaggacgctg aaaatcacaa ggcttacttg 392581 aaatctcatc aagttcaccg tcacaaactt aaggaaatgg aaaaggagga acctttgttg 392641 aatgaagaca aggagagaac tgttcttttc cctatcaagt accatgaaat ctggcaagcc 392701 tacaagcgtg ccgaagcttc tttctggacc gctgaagaaa ttgatttgtc taaggatatc 392761 catgactgga acaacagaat gaacgaaaac gagagatttt tcatttccag agttcttgcc 392821 tttttcgccg cttctgacgg tattgttaat gaaaacttgg ttgaaaactt ctccaccgaa 392881 gtccaaattc cagaggcaaa gagtttctac ggtttccaaa tcatgattga aaatattcac 392941 tctgaaactt actccttgtt gatcgatact tacatcaagg accctaaaga aagtgaattc 393001 ttgttcaatg ccattcacac catcccagaa atcggtgaga aggccgaatg ggctttaaga 393061 tggattcaag acgctgacgc cttgtttggt gaaagactag ttgcctttgc ctccattgaa 393121 ggtgtctttt tctccggttc ctttgcctcc attttctggt tgaaaaagag aggtatgatg 393181 cccggtttaa ccttttccaa cgaattgatc tgtagagacg aaggtttgca caccgacttt 393241 gcatgcttgt tgttcgccca tttgaagaac aaaccagacc cagccattgt tgaaaaaatt 393301 gtcaccgagg ctgtggaaat tgaacaaaga tacttcttgg acgccttacc agttgctttg 393361 ctaggtatga acgctgactt aatgaaccaa tacgttgagt tcgtcgccga cagactgttg 393421 gttgctttcg gtaacaagaa atactacaag gtcgaaaacc ccttcgattt catggaaaac 393481 atctccttgg ccggtaagac caacttcttc gaaaagagag tttctgacta ccaaaaggct 393541 ggtgttatgt ccaagtcgac taagcaagaa gccggtgctt tcaccttcaa cgaagacttt 393601 taagagtatc tctctatata tttcttttta cgcagtctct tcaatctctt tatgtgggct 393661 ttcgcacctc ttatttatat atatatatat acactgaatc atataaactt ttttttatat 393721 tgaatctaat atattatcaa acggaaactt cggctgaatt tcatacgtat attgattaaa 393781 gtggaaaggg catcggaaaa gtaagaaaag cttaaaaaaa ttgaaaaaaa aaaaaaaaaa 393841 aataaaaaat aaaaaataaa aaaacctata caatacatac atatgtatat gaatataaac 393901 ctggaacgat gtgtctttaa aaatagttga acgaactact cggacatacc cctacatcac 393961 ttaaggatgt ctactttcat aagaggtccc atctgcggta cagacaactg cccctcacgg 394021 ctttggcgta tcattgatgg gagaagaacc tgccaatatg gtcacgttat ggaaggtgac 394081 gtggaattta acgacgatga agatgatctc aacggcctcg gtgcaggtgt tatcacaaga 394141 cgtctgaatc ttaccaccaa tgccactggt agttttcaat ctagtcaact taccaactcg 394201 caactgctgc aacaacagca aaggcaatct cataaaaaat ttaaaaaact tatcggtcat 394261 gaggccaaat tactatttct caaatccttc cagttcatct tgaaaaggca aatccgctgg 394321 ctcataactg aaatgcggtt tccgaaagag ttcgaacatg tcgccaagat aatttggctc 394381 aagatattaa agacgattaa cgaccaaccg caagaagaac taaaacttca attacatatg 394441 acttcgacaa tttcgatcct ctaccttgca tccactcatt tgtccctacc agtttatacc 394501 tgtgactaca tcaaatggat atgcaccgcc aaaatgccgt atttccaggc aagtgaaata 394561 ctaccgaaat cgtggaggat ccagctgcca aattattatg tttccatact agagggctca 394621 atttcacctt ttaatgggca actgtacaac aaaatcgcat tgacgtgtgg tatgatccac 394681 ttcaaagaat tcttcaactc tgaaatttcg tgtcagggct tattactgaa actagtgatg 394741 caatgcgctc ttcctccaga attttatttt tataccaaac aagttatcga atttgaagaa 394801 acagacattc ggaacctgac actgtgggaa agaacggacg aacgtcacac agggcgagta 394861 agtaatcatg ccgaactcag ggtcctctct tattttatgc tcacaataaa ttggatgctt 394921 tcttttgata gagaccgaca atacccacta aaatggatcc tttccctcac ggaatcattg 394981 actcagcgca caaccacaag tgaatctatc ggcagaaata tcgttaaagt ggtttaccca 395041 gacaaaccga cttctagtga ttatttccag tggtctgagg aggagaccct agagtttttg 395101 aagtggatgg aaaagcaatt tttgcccaca caaacaaaat ctttgcataa tgagaatggt 395161 tcgatggaga tgacaattga tcaaaaaatt gctagaagga aactgtacaa gattttcccc 395221 ttggatcgag aggccaatca tgatggcgaa tttaatgact caacgcatca gttaactttt 395281 attgaagatc tgcaagaaag atacgctaaa caaaccccct tttttgaaag caacaaaata 395341 cgtgattctc tcaattatca agaggctaat ccaccggcca gaaaggaggc tatcggtaga 395401 cttctaaccc atatagcatc acagctttta gtggattttg ccatttctaa agagcaactg 395461 aaagactgca tttcaaggat caaaaatgcc tgtctgcata ggatgaattg actcctttta 395521 aattattctc gctggattgc tatttctatg catactcctt gaattacata taccaatctg 395581 catatattat aggtacatat taatatagaa atgtatccta ttttacattg tttctataac 395641 ttttacatta tcagaactta tttttttcct gtcaaaaaga aagaaaactc attctctaga 395701 cacagcgaga tcttactttt cctaacggtg tgaccatatt gtacgtacaa tattatctat 395761 gttttatgac cagatctagt tttaaacaga attttaaagg gagggtgcct aattttgtat 395821 tatatattaa aaaagctggg aaatgcccgg ctcagctaat tttcttcaag ccggttttac 395881 gtgcagatct tgacgaacga aaataaccat catccgatta atttgtttgt ttattgcccc 395941 gttgcccatt gtgcaaatcc gccttgagca aacgcttgta gtgcgcttcc aaatccagtg 396001 gacgttagtc ttccaatttt actatctgtg gactcggcag ctttgttgag ttcgtcaaca 396061 gaagcaacta ttctgttcac atttgtttca atgaccatgc ccccctgcac gatttcttct 396121 aatacacttt ccaaagtttg ccagttaaaa atcaaatcaa gttcattgac ttcagtaaaa 396181 caacggtcca atgattccac aaaagtttgg atcagatcta atatggccag ttctgattct 396241 tgatcatcca cgatgaaagt gaaatatagt gtagcgtagt ttttatagat gatttgaata 396301 tcttcattgt ttacctcatc attattattt tcattgctta acagaagcga tggtggcgtg 396361 actaaaaaag aactttgaaa atcgctattc ctttgagaaa tcaattcata tacttgctct 396421 aatagcagtt tttgctttgg aaggtcgacc ggcgtgtaga atttcactaa tcttggttgg 396481 catttcttat tgactatacc aaaaatgatg aattatgtta gtaatgtata attttggcag 396541 aagaaaagac ccttgagaaa tcttacatac atattagaac tgcatgaatc attgtgtaac 396601 gttatatgtg ttctggcctc tgtaacccag atctggtata gttacaacag aaatgatatt 396661 gttccagtgg actatttaaa aaaaatatac tcctacaacg taagagaaga aatataaaaa 396721 agaaatgcgc aagcccggaa tcgaaccggg ggcccaacga tggcaacgtt ggattttacc 396781 actaaaccac ttgcgcttac ttttgatatg aatctttcat tcatactcaa tattaataag 396841 caagatattt tttgaaatga agaaccttaa tcgagccatc gtattcaaaa agaaagaaaa 396901 aagactgaat gagaactatt tttttattgc cttatagaga attacttgag actttttttt 396961 tttgcctaaa atatatgact ttattttcgc ttggcctttc ttacctcgtt ttgtgattac 397021 tcattactta catcagcgta agctttccat atctataaca tttatgaaag tggaactcct 397081 catactcaaa agttattgct atccatttat attgtgatct taccattaag atatatagca 397141 gatcataatg gcttgattct aatactcctc gagtatgacc atgcaacggt tcaaaatccc 397201 gggttgtaaa tatttctttt atcacgaaac atgagtgaca accacttaga ctcgaaagtg 397261 acgttcttgt atttgcacat tcgatgataa atatttaaaa cgtatatgta gatacatagt 397321 ggacagcaag agagatgcat ggttggccca tttctcagcc ttctgtttgt tctcttctta 397381 attcaaatgg aaacttgttg atctcgagta tcttgttaat tgtttgaacg tttatactgt 397441 cattgaacga ttctacccaa tttttgcctt tcgtgccttt ttttggggtc aagaacccat 397501 cccaatccaa attggcaacc ttttgaacgc ttctattgac ctcgtcatta aattctccta 397561 acatatcttt atcaggaaat atgctaacaa tgtataaata atagccgtcc tttgcggttc 397621 ccacagtact tctaccaagg ttatctaaaa aacttttctt tggcttgccc ttcatgctag 397681 caggattaat atttggagat ctgttaagat taacgtactc tcgaatggcc ttatcaccat 397741 ttagtttaca ccactccttg ataaacgttg ttttcacctt taattttaaa tctcgtctca 397801 agtacgcaaa ttcagaggga atactgtttc tatgtctatt tgtaagccgt gtcatcgctg 397861 tttgaatttt gcttagttcg acttcattag cttttgatat cctagtttca ttgaaatatt 397921 ctttgtcctt gttgaaaacc ttcccattta aataaaactt cttattggat tttaccgtta 397981 ttgctggttt actttttcta aaacaagaca taaaatggtc ttcagggaag taatgaagtt 398041 gaaagaatct actagtgtat accaatgagt taggggaaaa tttttttcca atcgtcacat 398101 aggcttggat gggtgaaatt acacctcgaa gtttaccagc aacaaatttc actggatccc 398161 agtttctttc ttcttctttt tgtaaatcag ttagcgtact taatatagta ttttcagcat 398221 ttaagcacac agctgaattt cctgaatcgc tttttcgaag gtcaccaaga gaaagaggct 398281 cggtattctt cgtcactata aattttgaaa agggatcact actatgtata gtggttgatg 398341 gtcgaattac cagtttgcct ttaggttttt gcgataagag tgtggagaat atcttcatga 398401 tttggttttt ctattaacct tcttaatctt ttctttcttc atctgccatc gcctttctat 398461 gttttccgta tttcttcccc gcaagttctt taaactcaga tagtattaga atcgataatt 398521 aaggccaggt caaagttcgt attaatttca acctttgggc acctatattg gattaatttc 398581 cgtaagataa tatatgagag cactatcatg gagtgatgaa gaaaaattca aactctaggg 398641 gcaaaccgtt tgttacgatt gctcaaaaat tactgcgtct gaagccagaa ttgtaggtat 398701 atacgaaaag gtacaacttg ggatactatt gacggcggta agataagtga atcctacctt 398761 tcgttttgag ccgctcaaat aagacctgat acaaaaacgg ttgtttaatc tttgtatagt 398821 ttcttctgta gaagagttat gaaaatatac acttaaacta taacgataag aaaatgcgaa 398881 aggaaaatga tgaaatcgaa agcattcaca atttcccctt ggaagcattg ggtaaattac 398941 caacctacgt atcctctcgc aacaattctg aaaaccttta acttcccact tttcatatgg 399001 cttagcttgt agctgttttg aataatcttt ccctcgtgat tttcgataac tctaaactta 399061 ttctttgtaa aatcataatc agtaacaaca ctcgaatacg gagcggcgga gtccattcca 399121 acgttgataa tttcgttttt tccgatcttt ttatgagctt caaatttggc ctttctaatt 399181 acaagaatgt cacctggttt aatcttctgt aagctcttca tcaactgttc gattccttct 399241 tcaggtttat aactcaatat agttgcgcca aacgttcttg ctcctatggg ttgtataact 399301 tcgtctttga attcggatac aatttgtgac acgaaattct tagccccaat atgtgaattt 399361 atcaatgaat gagatttctc tacaactttc gcattaaacc tttgagcgta ttcatcaaga 399421 atacgtgctg attgtgtttc gactggcgat ggaaagcgtt cttgaagagt cgttaccgtt 399481 ttctctgggc ttgtactatt aaaggtcaag gagaatctta gttgcgaata gttttcaaac 399541 aagaagtaaa aatcccttac cacccatttt tgatgtaatc ttttggaaat gaaatgatca 399601 tcgatctcca tcaaaaagtt caacttcaga ttgcttatag caggaggtgc gcttttatta 399661 atccaccatc tttcttgtgc attaaactct atcttgacgt tgttggaaat ctcgcctaca 399721 tcatgcgtcg ttgaccttct tatagaggcc accttcggtg tagtatctga ctcatggaat 399781 gaatccacag gacgattcgt caatgaaggc acatggggcg gtagggttcg tgattctttt 399841 tctgccccag atagtactga ggttggcaca cgttgttgcg tactcatcat tgaaggtgta 399901 gaggccgtga cattttgatg tggtggagga gaaggagctg tatgtgaatg agtggctgtt 399961 ggttcagagt caaattcaaa agtagccggt ggtactggtg gtgcacgtgg aagtggcgga 400021 gcagtatttg gcataggatg atattcctcg gatacaggtg gaaggggagc agatgacttg 400081 acatgttctt ctacttcatt gtgtttaggc agcgcaagag gcgctggagg tgctggaggt 400141 gctggaggtg ttggaggtac tggaggtatt gaaggtgctg agagtgctgg aggtgctgaa 400201 gatactggag gtactggggg tactgggggt actgaaggtg cagagagtgc tggaggtgct 400261 ggaggtactg gaggtgcaga gggtactgaa ggtgcagagg gtactggagg tgcagagggt 400321 gcagaaggca ctgggtgagg tggcaccttg tcctcaggat gtgacacctt acttagaact 400381 ggagctgctg gagctgccat cgaaatatct tgagcggttt ctgttaatgc agatgaatta 400441 gtggaaactg tatcatgata ctcgtttatg gatttccgcc gattttcccc tgaaatggat 400501 ttagtcaaag aatttatcga cccgttgcga gcaactcttg tttgtgggga agagacaggc 400561 aaaacatttc cagttgtgtt ttgtgatgaa ttttcaatat catgtgatac ttctgcagta 400621 cggtgggaga ttggtggttc ttgagggtaa attttttctc cggaattaac attctctgac 400681 tcattattac ctatctgaaa agcttgctcc accatcgaat gctttctcaa cccatcgttt 400741 gcatcctcaa actcgtggtc gtcagtatct tcatcagaat catggtcaga gtattcggga 400801 tgtgcattat caacagcagc taaattgtga taggcgtgtg taccatgttc ttgcttctgt 400861 tcatgctctg tggttgcatg aggatctagc gtctttgttt cagtgggttg attcttctca 400921 cttagatttg atttcctaaa aaatgggtta gaacttgggt caacaaatgg cataacaggt 400981 atggcacgag gtagttcttg gagctgttca ggttcctcct cctccttctc cttatgctgt 401041 ttctttttcg gctcttctga tggtttattt ccaactccag aagccatacc gaaggggtta 401101 aaaccaacag gagcaccgaa tctactagcg ccagatagtt tagccattct ttctctcaat 401161 gcggccctac gattctcttc actatcttcc tcttcttttt cctcatcatt atctccctct 401221 ctgtcttcat ggccgtaacc tatttcgctt tcctcagcaa cattttctcc tcttgcctcg 401281 tctgcttgtg actcctcaac tttctgattt tcctttgtgt actcatctaa aaattgttct 401341 ttctctatgt cattcgtgcc ttcatctgct tcgcgtgagg ttttagtaat ctctttatgt 401401 gccaataatt ccatttgcgg ttcctcgttg tgctcagttt caggcgtaaa ttcaggtttc 401461 ggttcagttt tttcattttc ttctgcttct tcagtttccg tatagggctc attcttgtta 401521 accgcactac gttcatgttc ttgttcgagc ttagcctttt ttctcaagag ttcttcttct 401581 cttgcagcct gtaatctttg ttgctcctgt aaaagagcaa ttctttcttt aaggctcatc 401641 tggggcaaat ccttctttaa ttggtcattc tcagtttcta ttcttccact ttccacctgt 401701 gcacgattaa ttggttcggg aacaatcttt ttttcgtttt cctttaggga ctttttcctt 401761 tcaagattgg acgtatcatt tgttggaatt ccagggggga catagtattt aggagcatct 401821 gccacaattg tttttttcac aggtatgttt tctaaatcca agtgagttga ttttggtaaa 401881 ggaacttgct ccgttatatc ttgattaaac atagataagc gagccttcaa ttttggagaa 401941 tccatgggaa cttttctttc gccattacca ctactactat catgctggac ctgtgctgat 402001 actgctgtag cggctggaac tggcactgta gcggctggaa ctggcactgt agcggctgga 402061 actggcactg gcccggacag agtttctttc ttcgtttcag gggaaatggg ctctggtagg 402121 tccttttgtt ctacttccgg ctggattgta cgttgctcag tggaaccggt attcggagat 402181 gattcggctt cctttccaac ttcagatccc tgaacagcaa caaaactttt cgggaagata 402241 ccctcaataa cgtcgccatt tgaatcctgg tattcaccaa agtaccattc ggcgtcttca 402301 acagacgtaa caataatctc ttgatctttt tcaaaattta aatcgtcctc gtaatcggac 402361 ttgtatggga actgagccac caccttgaag ggcacttcgg gttcactcat ccttagtttg 402421 ggtaagactg tgtttacttc tagtagctct tgcagttggg acgcgattga tgtttactac 402481 cgacttgacg ctactgtttc acagtgtgct agtaaatacc acttctagtt gaagtcttaa 402541 ggagattata attctggagg taaaataggg gcattgtaga cctctaacta ttttcagggt 402601 atattcctat attatatagg tttattctta aaatatgagg tttataaatg atacacatca 402661 cttattgata gggttatact ctttgatacg ggtaacatat gagacgcgaa aatggaatat 402721 aatgacaatg taaatatcgt catcttgaga taattatcaa caaggttgtc atgaggagtt 402781 acagataaaa gtcaacagag tggagttagt ggtgttttaa ctgtagtgct ccatagtttc 402841 acggcggttt ctcttgtttt cagttggtag taacttttat cctggaagtg ctggaaatga 402901 ataactcaaa tgagcatagg cgggaagagg caggagcggc taatgaacaa atgccttaca 402961 ataaggctgt aaagtccgcg tatgcagatg tcctcaagga caaaatgaat agggaacagg 403021 agattagcct acgagccatc aaaaaaggga tatacaccga tggcggtgaa actgacaact 403081 atgatatgga taaagagaat gattccgcgt acgaaatgtt caaaaaaaat cttgattttc 403141 cgttagacca acataatgat gacgacgatg atgatccgta cattgaggat aatggacaag 403201 agaccgacgg atatagcgac gaggactata cagatgaggc agacaagagt tttatagaag 403261 acagcgattc cgacagctac gatttggaaa gtaattctga ctttgaagag aacttggaaa 403321 gttcaggtga agctaagaag ttgaagtggc ggacgtacat tttctatgga ggccttttct 403381 tcgtttttta tttttttgga tcttttttga tgacaaccgt gaaaaataat gatttagaaa 403441 gccattcatc cggcgctaca tcctctccag gcaaatcatt cagcaaccta caaaaacagg 403501 tgaatcattt atatagtgag ttgagtaagc gggacgaaaa gcacagttca gaattggata 403561 aaacagtaaa aatcattgtc tctcaatttg aaaagaatat taaaagactt ttaccctcaa 403621 atttggttaa ttttgaaaat gacattaact cgctgacaaa acaggttgag acaatttcaa 403681 cttccatgag tgagttacag aggcgaaatc acaaatttac ggtcgagaat gttactcaat 403741 ggcaagatca actggtaaaa cagttggata cacacctccc tcaagaaata cccgttgtaa 403801 ttaataattc ttcgtcgctt ttaataatcc ctgaattgca caattatttg agtgctttga 403861 tttcagacgt tattgagtct ccaggcattg gtactgctgg aagcgctgaa agtcgttggg 403921 agtatgattt gaatcgctat gtaaaggaaa ttctttcgaa tgagttgcaa tatatcgata 403981 aggattattt catccaagaa atgaacagaa ggttgcaatc taacaaacag gagatttggg 404041 aagagatcac aaataggtta gagacacagc agcagcagca gcagcagcag gttcaacagg 404101 attattctaa cgtgccacag cagtattcga gcatattaat gaaaagatta attcaccaaa 404161 tttacaattc caatcaacac caatgggagg acgatttaga ttttgctact tatgttcaag 404221 gtactaaact attgaaccat ttaacttcac caacctggag acagggcagt ggggtacagc 404281 cgatagaatt actgaccgac tccaaacaaa gctcctcaac ttactggcaa tgtgagaacg 404341 aacctgggtg ttcatgggcc ataaggttta aaactccttt gtatctaacc aaaatttcgt 404401 acatgcatgg ccgttttact aataacctac atataatgaa ctcagcacca agactgatct 404461 cattatatgt aaaactgtca cagactaaag agatcaaagc attgcagaca ttggcaaatc 404521 aatacggttt cgggcagcat cacaagagag accgaaatta catcaagatc gcaaaatttg 404581 agtacaggtt gacagattct agaatacgcc aacaaatgta tctgccccca tggttcattc 404641 agttaaaacc actcgtacgc tcaattgtct ttcaagtgga cgagaactac gggaacaaaa 404701 agttcatatc tctgaggaaa tttatcatca acggagtgac accgcaggat ttgcaaataa 404761 ttgaaaataa cgagttccct gttttactgg gtgacacccc agaatatggt gtcactcaga 404821 acaccgacga aggcaagagg aaagttctcc tatcaaagcc tccttacgcg tcttcatcta 404881 ctagtaccaa gtttcatccc gcttctaacg tcccatcatt tggccaagat gagctagatc 404941 aataaacgac aataaaaaat taaacgttct aaccccctgg cccccagaaa atcgcgcaga 405001 ttgacggcac tccctttaaa tcatagagtt aatcagctac tcaccactct ctttcggtac 405061 tggcgttatt ctgaattcca accttgaaca cagccacacg gcattcagat gttgctccca 405121 tgcgtggact cacgctctgc gattaacagc tcatggaaat ttcctcgtgc tatttaagac 405181 tgcagtcgtt tggaaatcgg aatatctttt ttcgtgcagt tttgcgggaa attttcccta 405241 cttaaaaagc tgaatgaaaa tcagaaatat ctgcaaaaaa aaaaggtaaa aaagggaaat 405301 tttaagacat agcataaagg acttggtttt gtttcaatac tcagcccttt tcattcattt 405361 ctatcacaag tttttttttg ctctcgtttc cattttcttc gtttacttat tattgacgta 405421 catctttttt agtttcaaat aacatagcaa gaaggcttaa ctaagttcct atattcttgg 405481 catatttatc atcatcaggt cttttaaaag tatctcagaa cgtaacttca acgcctttag 405541 atttttttca caacacgact ctattgcaag agacaaaaaa aattaaaatg ggcattttgg 405601 actcgctgaa aaaacctgtt aatatcaaga gttcgctccc caaattctcc cgcagtgcta 405661 ccagcatcaa tttaagtagc cacccagtaa gttcacggtc cttcctcgaa ttaccaccag 405721 agcttttcag catcactaaa cctatattta agcttctgca agcacacgca aataagattt 405781 acttccaatc ttccgacgct gaggctgtat ggaatgttaa ggattcttct ggacatgttt 405841 ttgaagcaga gtcaatttct ttgctcggct ctcatataat tatcacaaat tcctctgtac 405901 aagtcgcaga cgtggccatc atagattccc cttccaacat aaaccaatgt gaaatttcaa 405961 gcgttggaga gttcctgcaa ttcaataatg gccaactatc tatcacatgt aacgattttg 406021 gtttactgga gaagttcaaa aggttgtgta tgatttctat ttttgagttc atttctatat 406081 ataaggcctt gacaggcaca gtgatttcct cttatgggct gagaatgtct gatatgcata 406141 tcattttgaa ctcgccgttc aattttaagg attggtgtga agtttatctt gatggtcaag 406201 gttgggtgaa agtgtggtgt catattgata aagtgtctaa aaccaataat tctaaaagta 406261 gtagtgacaa tgatgctaaa ggaaagtatc aaatacggtt ttatagagat gacaaatcca 406321 catctagcaa gaactgcgtt ttttttattc ctgacaatga gtacgttcaa gatattttct 406381 tttataacat caatgcggca gaaccttcta aaaatatgaa cgactttttt caagggttgc 406441 aaatgataaa gctcgttggt aatgtacgct tttgcagtga tacggacttt aatgatgtgg 406501 tggatagtgg atccatctat agtagtgcaa acaacggcag tggtgacagc agctcgacag 406561 cattgaataa tgaaagtcct aacactacac caaaaagtag aactttcttt tcacctaaag 406621 ggcacagaag aaatagctcc catgtaagtt cgttaacttc tagatcaaca aaaaagccta 406681 taactaactt cactacacgt acaaatgggc ttttgattag gccattgccc catcatggcg 406741 tacatcacct ggaagcaatg atcaggttca ttattccttt gatggattgt gcaagacttt 406801 atgggcgtcc agttcaattc aagacagaaa gaaccgatat aaattcgtta atgtttggat 406861 tacctaaatt gccctcagtg gattattttg ctgaagagga gattgcccat ttgatgaccc 406921 aggaatttaa tcctttgaaa gaaaaagata ctgacgatac tatggcttta actatgtcaa 406981 gattttctag ctacctgcaa gaaagaatga caaaagtctc caagagaaac acagaactca 407041 acttcaggac ctttagtgat gtaatgggca tgtataatac tacgagggat cactctaaac 407101 ttaattgcat gagtgacaag gataattctg tgaaggaatt ttcattgagt gataaaagca 407161 atgttagttc tgaaacgact aatatgatga atcaattgca agtaaacgcc catgaataca 407221 aaagttctat gtgcgaacgt cctatcgtcg caagtacttc gcccattgca tagttcttcg 407281 catatatagc cacatctcaa aaacttacat acagtgtata tatttgtggt acagtttctg 407341 tatagccaaa tataccctga tataatctta tgtgatatta tatacttcca tcctaatact 407401 aaactttttc gtttaacgtg acgcatggtg cgaagaaaaa aaaatagcaa atcgccactc 407461 aataaagtga gtagagagca ttatatcaaa aaagcatcga taatatcgag tgatcatacg 407521 ttgaaaatca tcaagtacaa tagtgatata agccacaatg caagctccag tggtatttat 407581 gaatgcttct caagagagaa ctaccggtcg tcaggcccaa atctccaata tcactgctgc 407641 aaaggcagtt gccgatgtca ttcgaacttg cttaggtcca aaagctatgt taaagatgtt 407701 attggatcct atgggcggtc ttgtgttgac taacgatggc cacgctattt taagggaaat 407761 tgatgttgca catccagcag ctaaatcaat gttggagtta tcccgtactc aagacgaaga 407821 ggttggtgac gggactacaa cagttattat tctagctggt gagattttag ctcagtgtgc 407881 accttatttg attgaaaaaa atattcaccc tgttattatt atccaagcct tgaagaaagc 407941 actgactgat gcactagaag ttatcaaaca agtaagtaaa cctgtcgatg tggaaaatga 408001 tgccgctatg aaaaaattga ttcaagcctc tatcggtact aaatatgtca tacattggtc 408061 agagaaaatg tgtgaattag ctctagacgc tgttaagact gtccgtaaag acctgggaca 408121 aactgtggaa ggtgaaccta attttgaaat cgatatcaaa agatatgtcc gtgtggagaa 408181 gattcctggg ggggatgttc tagattctcg cgtcttaaag ggtgtcttat tgaacaagga 408241 tgttgttcat ccaaagatgt cccgtcacat agagaatcca cgtgttgttc ttttggattg 408301 tccactagaa tataagaagg gtgaatctca aaccaacata gaaattgaaa aggaggaaga 408361 ttggaatagg attttacaaa tcgaggaaga acaagttcag ctaatgtgtg aacaaatttt 408421 agccgttagg ccaacactag tcatcactga aaaaggtgtt tcagatctag cacagcatta 408481 tttactaaag ggtggatgta gtgttttaag aagagtgaag aaatcagaca ataatagaat 408541 tgctcgtgta actggtgcaa ccattgtcaa tcgtgtagag gacttgaagg aaagtgatgt 408601 cggtacaaac tgtggattat tcaaagtaga aatgattggg gacgaatatt tctcattttt 408661 ggataactgc aaggaaccaa aagcttgtac cataatgtta cgtggtggtt ccaaagatat 408721 attaaacgaa atagatcgta acctacaaga tgctatggct gttgctcgta atgtgatgtt 408781 gagtccttcc ttgtccccag gtggtggtgc caccgagatg gcagtttctg tcaaattagc 408841 agaaaaggca aagcaattag aagggatcca gcaatggcca taccaagctg tagctgatgc 408901 tatggagtgt attccacgta ctttgataca aaatgcaggt ggtgatccta ttagactcct 408961 atcccaacta agagccaaac acgcacaggg aaattttaca acaggtattg atggtgacaa 409021 ggggaaaatt gtagatatgg ttagttacgg tatttgggaa cctgaagtca tcaagcagca 409081 aagtgtcaaa accgctattg aaagtgcatg tttactatta agggttgatg atattgttag 409141 tggtgtaaga aaacaagaat aatagcctcg aggttaaact tcattactgc cgtttaatat 409201 ttggtgtttc ttcacatttt tttgtttttt tatactattg taatgtattt atatagaatt 409261 aaagtcctca ctataatttt gtcatcccta cagtatgtca taagcgttaa tcggacaaac 409321 gttcatttta aaattggcct ttttatattt atattactcc tcataggatt taatatagaa 409381 gtatcattcg ttaaataatc attatatcat ctgtgcttta aataaaaaag tcggccgtcg 409441 atgtgtttac gattggccag tatacttact cattcatggg attagtttta tttcaacgct 409501 gtggtgggta cgatatgaaa gacgaactcg acttgtcatc atctgaaatg atctcagaat 409561 ttttgctttg agaaaaagaa tttgattctc tcatttctaa aattggggtt aactgccgcg 409621 gcttgacagc tgagatgata tcagacgtct cagtgcttcg tccctttggc gtcatagggc 409681 agtttatgta ctcttcgcca gaaaacattc ttccctggtt tgagggggtc aacgacttgg 409741 agactaaggc ttttctactt atttttggtc ttttcgattg tgcttcagct tctttttgat 409801 ttgcgctttc ttcttgccct aaatttgctt ctcttggatg tttcctattt gtcctaaccc 409861 ttttataaac gtttctagaa attgccaaga cttcttctag cgaaaattct agtctaccac 409921 ctttagattc ctcatcttca caataaatca gtttaaaatt acagtcaatt ttttctggtt 409981 tctggtcctt tgtattaatc atttgataaa cagggtcact tctacctata gaatctctaa 410041 agatcggtag tttttcatca tatggtctct ttttttgcga taacatctca tgttgtttaa 410101 gctcacccaa attggtattt gcttctagca atgatattcg aaggttgttt tctttgttcc 410161 tttctgcctt taagtcaaaa ttttcccagc catctctata aacacctcta ttcggagttt 410221 cgaatagttc tacatcagac tcttctccat ctacaaatac gttgtttttt gttaaattga 410281 cgtcacttga tgtgccattt tgatttgcaa gctctagtct attgacaaat tcagatctgg 410341 ttttcccaag tactgtagac tctaatgagt ccatcgatat ttcatttcct agctgaatat 410401 tgttctcccc cagttctctc aggagatggt ttaaccggtc ttctaaaacc ttattaggcc 410461 tagccttatt tttgattcct agctgtagaa ttttcacggc atattgaaat ttttctttct 410521 gaattaatag attcgtaaat tcttcataaa atgacgctaa ctcggaacca attccatttc 410581 ttaacatata catgaaaatg tctctgcttt ccatgaatga atttctggta aaaagttcta 410641 tgtaccaaaa ccatatttta agaaacctaa catcattgcg atatctctcc aaatccttta 410701 agtgagataa acatcgctcc aaaagggtga gcattccaga ttgtttggaa ttaccgcctt 410761 gtggataggc gttgttcagc cactttatgt attcaagata caaagtaatt gggtcgctta 410821 atgcagggag ctcatctatc agtctttgtt cgaagcttga tttaacttgg tttatttcca 410881 ccagtggttg atgtatcgct ttcgagagtg ccgctgctga tctgccttcc ttcaggggaa 410941 gaatgttttc tttttgagtt tcgatttctt caaagttaat aacattttgt gatggtgacg 411001 atggcatgta agagatacgt ttctttgcgt acgctttcat tctatcaagt taacgtcttt 411061 tattgtattt tcgcatgatt ttgtttacta tttttgaacc agtgtgcgcc tggtgaaggt 411121 gtgcatttca ggcaagaggg tagttctcat atataaaaaa atggcgctaa agaaattatt 411181 atatctaata tgattattac ttaattatac agtaaaaaaa acacgctgtg tattcattta 411241 gcaactaggt tgcagaaaaa ggaaaataaa atagagagaa ttagaaacac agaaaccatg 411301 ccgggcccga tcttatcctc ataatctact gctctcttta gtctaatgtt taccactctc 411361 ttggcataaa ccataacagt acgtatcaac acagccaagg aagtaataaa gaacccaatg 411421 gagccaatca tggctgttgg tgaaccatat gttaataaag tagtggagac accgcccaac 411481 aatatcgaga tggacaacca agacaggtag gttctttcag tggcaaagta aacttttggt 411541 tccacacgaa ctggcacaca tatcgtcttt cccggtgggg cacgaatttg agtatcaaaa 411601 gtagtacctt ttgggatttt agatatttga tcaccgttaa aatagtggtc aaaaaatgcc 411661 acgatttcat agtatttctt ggagatagga ttttcggcat tcctgatctt tctttgataa 411721 taagcagcat tagcactctc aacaacatga ttagtgttgg aggtgggggc cgaagtagcc 411781 ccgtaaccaa cagattcttc tatatcaaga gaattaccgg gtgcgtttgt catggcagca 411841 accaaagcag cgtcatcctc atcatcctca tcgaagtcgt tatcttcgtt atcggatcta 411901 ccgggtcttg ttatttcaat atttgttggt agtggaggtt tcctgatatc aacatccatt 411961 tgaggtaacc aaaatgggat tgaatccact ttatcattta gtaaggtagc cacaccatga 412021 ataaacttgg agaattttgg gactggctca actaagtgag acccgactaa ttcacgtacc 412081 cactctggag gttcttgacc tagttgagtt tgcaatttaa cttccaggac tgcatatggg 412141 aaacggcaaa tatccttgtc atctagctgc ttgaatggcc aatcgacacc aatatcagtt 412201 ctcctccaat tcttatgagt tctatccaca ccatcaaagt tgtcttctct caccatagtt 412261 aactctgtat caagggagat acgaactctt gcatcaccag gtaattgaaa agcagttcta 412321 ttgtagaatg atctcactac aggtctcaac tttttcttta acatgacgta ttgaatttcg 412381 gatgctaacg cctccaagtt ttcaatttcg ttcattggct tcttgccttc tttacgcatc 412441 ttggcaaata cttgatcaac agtatattta ccctttaaga agtcattaac atgacgttcc 412501 tttagcgcaa atcttgcctt gacagatttc tcaccagtcc aatcctctct atgggtcttt 412561 ctttctacaa agatcgtgtc tgtagacata cccccatacc atctcaatct gtgggcttct 412621 gcaccttcat cttttcttaa tctgccataa taaaggtcta gattttcatt atcaaaatag 412681 atcgaagtaa tagcggaatc ttctctttcg aattccttat tagtgttgaa gactaacact 412741 ggtaaatgct tcaagatgat cagcttcaat tctgtaatgt tatcagggtg aacccaatac 412801 tttgttgtct gtctaacgaa attttgttgc ttcccaccag cagatgagtc tcccttgatt 412861 gggcgacctg aagttctggc aatatcatat agttgggaaa ttttaacgac tagttcgtca 412921 tagttttcct tgaaaaatgg tttagagtct aatctaactt ggaaaactgg tttcaagata 412981 aaacctgtct tcttatcgtg tttcttgata atcttttgga aaccagtgta gtttagtctc 413041 gaaaactttg ctagatcatg aacatcggca atgatatcac ttagttcttc ttctagaatc 413101 tcaaaatcta gctgagtagg aggattattg gagtctaaca aacgaacagt atgttgcact 413161 tgttcttgaa cctcttttac acgtctaaaa acttcactat gcttaacttt gcaaaatgtg 413221 taaaccttgt ctaactcgat ctccaaagat tctaaaaaat ctgtttccaa ttcttgcgtc 413281 cactgaccgt tattcttaga taagttatct tctagctcag tcttcagatc atcataacta 413341 atataatagt agctgtactg tctaataaga gacttgctca agtgctcacc aaacttcata 413401 gctgttcctg ccttgttatg ctcttttatt ggccgatttg attgttagcc tgtaacttct 413461 ttctgattgc ctcaatatat aaagatagta ttgcttcttt ttcattcacg tgtgcagcca 413521 cgtgcggatg aataataaaa atgcaacata tatgcatagt gcggtgtgtg aaaaagtgaa 413581 cctacaagtc agtagctctc cgtcaaaacg cagacaaacc aattttttgt cggtgttttc 413641 ctgtgcaatt ccagtaagta acatattaat acaatttcct atgatgggtt acgtggaaag 413701 cagagaggca attgcgtgat taattcggaa tattagcaac gcttctctta gtatgaaaaa 413761 gctcttcgaa agactatatt tttgaaagct ttaatatgtt tataagttaa atattgtcga 413821 acttgtttgc gacagctctt gaagtcacgg tgcgtctttt tttactcgtc aactggtata 413881 acaatgcgta tgacaattat tatataacta ttactttatt cttgccatga agggattact 413941 gtaacgccct caactagtat acccttttaa gcctcgacaa aaatacagaa taaacaaaag 414001 ttaaatctca ccgaagttgc ttgtggtact ggctttacag acgtttataa cgcagcacta 414061 aatttccaaa taataacctt cctccaatgg aaataaaaaa aatcgagact aacccaaagt 414121 gtgcgcaata aactctaaaa aataaagtat attcttgtaa atatttctat atgcttaagt 414181 tcaataatac atgcatactc attgaacatg ttatattgtt acacaacaaa gtaatttctg 414241 tttttcggaa gtgccagtcc aaatcaattc aaagcactgt acactcatgc gtagccagag 414301 atgatctcta gcatttcctc aattgttttt tcgtcaaatc ttgcatcaca ctcctccact 414361 atggagtaaa ggtggaccat attggcagga agttgattga caatctgcag tttttcagcc 414421 ttgaataatt taaaagaatt cagtttagtc atcaactcag caaagctttc atcgctcatt 414481 ttgcttatac ccgatttttc agcatctttt gcaccactgc tttctcgttc ctcgccttca 414541 tcttcctggt tgataaagtt tttgtttata ctgagatagt taaccacatt gcgagtaata 414601 ccttgcaatt caggatgatt gtagggccta ttctgcttac ctttcgagcg acttttcttc 414661 agcgcagcca aacttttttg gtcccaaaga tgtttttttt ctagatctgt taggaacttc 414721 aagacttcat agtcacttaa aaatgcattc ctttcctcaa gaactttcat aacgtttaaa 414781 gttttttgtt taagtgtcga ttttttcagt ggtgggtgtt ggattcactc aacttctctt 414841 ctactgtggc tgttatttgc ttaactttca tagatcgatg gcattgaaaa aaataatttt 414901 tcaggcaatt ttcctttttt tacttggtat aattttcagg aattgaagga tttttcaacg 414961 aattagcctt gttggcgcaa tcggtagcgc gtatgactct taatcataag gttaggggtt 415021 cgagccccct acagggctaa tatttttttc ttgcccactt attcaaggaa taagtgctaa 415081 ttatctttca accttgcagc gaagctttct tttgtatttc atctcataga aggtgaaata 415141 tcacactatt ttgtaaatag aaatagtata tgtagttcgt ggagaaccag actgcagact 415201 atcaataaaa ggttacattc tgttcaactc atgtgaccag aagtttgatt aagcaaaatt 415261 gttcttctcc ttaacatatg atattatctg aaggaatcta gaaaagcttg atcattccgc 415321 agaataacct atcaaaatga ttgggaggac cattttataa ttcatgctac atatataaca 415381 ttatacagta aaccctttta atgtaatgga ttgctcatag ttgtgtacac gaactgtttg 415441 ctaataagct tgttttagct tctattgcta aagaaattac tgacgaagag tttatgacaa 415501 ggaaagatga acgaaagtac aatttaccgg ttagtgtcag cgccaaagga tccacgcact 415561 agcaaaataa tgaaaattgt gccggatatt caagactaag agatgtacaa gttgaaatat 415621 aagtaaccct cggcataaac tactctgtcg taagatcatt aacatgtcga tttgcctgtg 415681 acatttaacg attcacaaat agcggaatta aatgatactt tatctatcct aaaacgcacg 415741 aagcatactt tagaatgcat gctcttagta agtatgcatt gccgacttct ctgtaagact 415801 tttatctcgt ttcagaccta atctgcaaca agagaaaggg aagaggacgg tattgttacg 415861 acgttattgg cggctaggaa agagagaatc accatgaacg atatggtgca aaaaaaataa 415921 aaaaataaat tgaaacggac aggaattgaa cctgcaaccc ttcgattgca atcttattcc 415981 gtggaatttc caagatttaa ttggagtcga aagctctacc attgagccac cgcttcaact 416041 tttgttgaaa atttaggcta acattttcta ataggtgaca ttacaaaatc cagtcttaca 416101 gttatgctta atattgacca gtagtcatat tactggcata ttatctgtta gaatagtgac 416161 atactattct ttattactga tgaatttgta attgtgaagc aattagacgc aaacgtcatt 416221 gatgtgtcag gatggagaac gatatagact atgtgataat gtaaagttaa atatctgtta 416281 cttgaacaat taacttgacg tttgtatatg taaggatatg ggtcattaca tagaaactat 416341 agtaaatagt ctcagtattg ttatatttgt catgtttgat atgactaatc ggcgcatgtt 416401 ttacacctct tttgtatagt ataagaagat ctgcttttat tcttgaaccc taccactatc 416461 tcgccaagtt tttaaaagat ccactgcgat cattgaagat tctatttcaa ataaaaatca 416521 actattacct atcatctagc attcatatta cttgtatatt atcatatctg taagaagatg 416581 acatgaatga tgagaaatag tcatcagact taataaaagc cgaaattcaa ggtcgataat 416641 gtaataggat agggtgttga atgacaatgt ataaaaggaa cgaagacaga gtaatactat 416701 tatgtaagaa ataccgattc ccttgtgagt atataaacat aaccatttca ttaaaataat 416761 ttattcaatg gtatgtatga tattataata acatacttat acttgtctca ctctgttcat 416821 aaacgcaaca atacaattac ttttgaatat tatctttaat aaatacactt agtagttacc 416881 aataaataat aaaatccttt actaatacta atataaggat ttctatgttc tcgaggagaa 416941 ctcgtagtat gttctgtatc cctaatattg tagcccttaa caacaatgga atacgaacaa 417001 ttttcttaat attcggctat ttctgaaata tacatattca cgggatacta ggaggtcagc 417061 atgttacaaa tttcatgata gtgcatcaag agaccctaaa attaatatcc tttatgtgcg 417121 tattgctttc atggtagtaa attatcactg ttttcatcta gacgtgggac ggtaacattt 417181 tcgataaata tcaaaagatg gcagtcattg tatagaatac cacaatttgt gagcatctct 417241 gaggtttttt acaagcttcc gtaactcata cagacttcta tcgtcctact ctagtattat 417301 ttacctattc ataaccactt ttttatcctt ctatttaaat ttatagatgc aaagggcgga 417361 aagaattgac tggaaagtaa actaaatata aaaaatatcg ccaacttatt catacaatat 417421 cgtagcaact gacaactttt aaaaatctgc aaaattcttt gtagtgttcc ttaataatgt 417481 ttaagctaag gttttttatt aagaggaaaa tattgcataa ttctataatt tacatcagta 417541 cagtagtaac atattatcca attatctata gtgcttttgc tttttgaagg cgcttccttc 417601 cttcgaatta tttctttctc ttgagtgctt ttctggcttt ggctgtagcg gtttagaatt 417661 tggaaatatt tcaaattctt gctccttaat tagttttttc caatcccaca tttttctaac 417721 atataattcc agtttccaat tcttccacac ttgcctgcca taaatactat tcttcacctt 417781 ctcagtttct aaaactaatg ctctagcaat acgctcctta tataatgtta attttgccgt 417841 aaattcccac aatttgtcca ttatatgaga gccatataca ttgcatgcca aatttacaga 417901 ctctttagac agtatgttca atagcatttt tctcttaatt atgtccaccc tagtagtttg 417961 tagtacgtgc tcaacaacat gcgaaaatac tccatggtaa cacatttgta tcaacctttc 418021 ctcaggcaga gccaacatgc tgtcaatggt aatattcaaa aacttgtcgt cgtagtcaat 418081 taattgttcc aagaaaactg atcgtcttct ttcttctgct gttggccagt catctctggt 418141 attgcccaaa gtcgatgcac tcaacaacag gcaactttcc aaaatattct ttgcatcaga 418201 cttttctgga taatattttt gtattaattg agcaatgaca tcatccctta agtaaccacc 418261 ttgtttattg cttgcgttga taatagcagt accaaaatcc atatttgagt ttaaaagcat 418321 gcttaattca ggaactactg catccaatat ctgttttacg tccttctcct tcaaatgttc 418381 cagcaatgca cgcactacaa aggcacctgt agtatccctt tttgctagtt tcacaatacg 418441 gtctttcata tataaacgat aaagtctttc aacatatttt agcctggcag agccaatcac 418501 attttctaag aaatgagaac cgacaggatc tgacagtaaa tattccagga atgattcctc 418561 cttaggatcc ttctcatctg ctgtattgaa gaccaatctc caaaatgaac ggtccctgtc 418621 aaaaatacct tcgacttgaa taatgagctg aattacaggg gaagccactt tatccacact 418681 gtactctcta aatttggtga tagtagattg cgaaatatca gaacgcgact cggcaccatt 418741 agtaaatcct ttgtataaag tagttattat gtcacgaagt tcagatttga aagattccgg 418801 tgtttggtaa actttattga aatcgtcatt atctttaatg tcaatcattt ttcttgcaat 418861 ttttgacttt ttggaacgta aagtagagtt cgctttagtt gaattaggca atgtcttgga 418921 agacaaaatt aatattagca atctcaaaac atgtgatgca tactgatggt tcatcatagt 418981 tttcaagtgc ggtttcagtt cattcaacat aaagagaaac atattttcca tagtcacata 419041 aggcccttct ttttcattgt tatcaaaact tggtgttaaa agttctcttt ctaccaaggc 419101 ggcacttcta acaaataaag tctctaaaac atgggaagca tatttatgac atgacaaccc 419161 gaagaaaacg ccattgaaag attggaaaat gtcttttaac tgagtctcat cacattcaag 419221 aataactcgt tccatcaatt tcgaagttat ttgggaagta accaatttca gttctttacc 419281 ttttgcttcc tcaataatgc tcgtgacgaa ttgaaacttt tcctcaggtg cttcgaaggc 419341 gtctaattgc aaagtcgatt cggcttgctt gaaatactcc agttcttctc tatctagcac 419401 accaaaaaac atttgtggct gagtctcttt aatttcggct tcgtcattgt aagtagactc 419461 ttcttgctgg atgtgctcct tcgcagaatt tgaactgggt tcaaattcgt cctttctctg 419521 tttgtcttgg tgtcttctgc ctcttgtttt agtctttccc ataataacaa taatgtggtt 419581 tttccgtgaa ggtttcagcg tcgttcacag tatactagtt gtaacagatc gcagctcatc 419641 taatataatt ttcttcatta tattgtagat gagcatgaaa attctcgcta accgaaaaaa 419701 aattgaaaaa aaaaaaagta ttacaatcat cgaacaaata tacaggccaa gagttcgtcg 419761 gttttgcagg ttgcttcttg gttaatgtat acagtacatc tgcattatca aaaattcaaa 419821 cattatatat atctttacta ctatacaggt acacatgata cagcctagca agtttgaaaa 419881 cttgattgca atttatgaca ttatattctg ctgtttgcag gtatatctac tttgtaagta 419941 taaagatgca aacaaatcag tcttcttggt cccagttacc tggccttggg ccttgaggtg 420001 ctcttggacc acccgccttc tttgccatga taatttggtc aatggaaagc acagtagttg 420061 cagcttctgt agcgacgtta atagcaaact ttttcgttgc aagcatgtca taaatatttt 420121 cctctctgat gtcctttaca ccttcatcag attcgccatc aatatccaca cctttatata 420181 aatgatctgt cttaactgca ccaggttcag ttacgttatg tgcagcgtat aagtttggta 420241 gtacctcatt aacatcaaga ccagcggtct ccgctagggt acgaggaacc acttcaaaag 420301 ccacggcaaa ctgttttata gctaactgta gcaatccagg tgttcgttca ccatacttag 420361 ttatcctaga aatcaattca atttcggtag caccagcacc aggcaacaac ttaccgcctg 420421 atggcttcat tagtcccttg acggctgcaa caccatcatc aatggctctt tcaatatcat 420481 ccaaattatt ctgtgtggca cctcttaaaa tgatagtaga tgttcttgaa atttcacctt 420541 gctcttgttt gaacacagtt actctatcac cacctatctc cattgtctta acagtttcca 420601 ctaaacctaa ttcttctgga gttggcgcac ctaatctagg caatggagtg gccccacaaa 420661 cgcgacataa tcttcttaat tcgaatttgc ttggtacctt caagactagt ataccgtatc 420721 tattcaaata atgtaacgcc aattcaccaa caccagcacc tgcaacaatg cattctacgc 420781 ccatgtcggc aatctctttc atcatggcat ctatttgctt ttcctcgccc ttagaaaaat 420841 cgagcatttc ttgtgcatta tgtaataaaa cagtgccttt cgtttcagta ttggctatgt 420901 caagcggaca agtgaaaact gcaactttat gctttttatc ttcggataat gattttacat 420961 ggccttcagg ctcacgattg aaaaccatac ctttgatgac ggtagaattg gaaagcgatc 421021 cacccataat ctttactact ctgatagaat caacattaaa ataaggaatt tctccagctt 421081 gctgagcaac tggtaaaacg tgagatacag cttcagaaac aagttcactc aatatgtctt 421141 cagatccgta ctttttggag gagatgactg gtttaatcat tttcaaaagt tcgtttttat 421201 cattcttgtc agtaatttca ccaacaacca tttcgtctag ttctttcaaa gtaaacttcc 421261 ttgccatatt ataaccttga ataatctcaa cggcagacaa gcccattgaa atcagttttt 421321 cggacacatt taatagttcg ccagccaaaa tcatgactaa atttgtaccg tctcccatgt 421381 cgatcttctg ttgttcagtc gccattacga ggactttcac tgcaggatgg acaatatcta 421441 gttctcttag catggtggcc gcgtcgttgg taataatgat tttaccgaga tggttaacaa 421501 tgatcttgtt tctaccacag ggtcccatag aagtcaaaca catttgatgt aattcgcgaa 421561 tggccgcaat tgatttaata atttggccat cggcgttaga gtaactattg tagccttgtt 421621 taaacaatcc cgcgttggga ttttgtggca atctaagtga catggttaat tgatgatttt 421681 attgcccttg aggttcaagt tgtcttgtcg gtatctgtaa agtgagaaca tcatcatgct 421741 atactatttt cttcactttt ttttgccact agcggaggtg atgaacattt tcgaataccg 421801 ttaataatga caaaaacacc attaacttgg cttatataaa ataagctatt gaaatagtaa 421861 atgtgctcgc aactctttaa ttatctaaat ccggcagctt ctttattgat taataataca 421921 aaatgttcgg acaagtgatc attagatatc aacatgaatt caattggtaa caatttcgat 421981 gcttacattt tatgctagta tacaccacgc atatgtctgt caatgtacct attacagaag 422041 gaaatgttca agaagcagtt cagacagtac cgaagcagaa ttaaaaatcc attatttgaa 422101 tatgatctga tagtcatata tatgagcaat acaggtcttc acattaaatg tatgagaact 422161 gccggaacca ctattacatt ggtcacaatt aggaatgaac caatcggcgt gtgttttata 422221 tcccccttat ataagtctaa gaagatcgat attcaatctt cattaataaa gctttttgac 422281 ctctacctat gagcaataaa ccatatccat caatagtggt caagccgtaa gaatgttttt 422341 accgagaata gaagtaaact tttcttattg tatataagaa aagcatataa acacgcgccc 422401 agagaacata ttcagtatgc cctagcttgg aaacacatca gtaaaatact acgcgcctag 422461 tataatgact tctatatcca aaatttttaa gttaaccttt caagtaaaag atctttgcct 422521 tatactactg tctgaacaac tcgtataaat taatgtatga tatgaacatt cccattgtta 422581 cgatagatgt cctaatgagg atcaactata atctatcgaa tagtattcat attactaata 422641 tattatcatg tacgatgtac caagatggca tgaagattga gaaaacagtc atcagattta 422701 atagatgctg aaatgccagg actgatagtg taacagaata atgaatgata tcatataaat 422761 tggggaaaca ataatgacaa tattatgtga aaatatcaat tctcttttgt ggattacaag 422821 atcccctgga gaacttctag tatgtcctgt atacccggtg ctatatcctt taataaccat 422881 ggaatccgca aatatttgat gtaaagtttg tttttcttcc ccaacatcct ttgtatgctt 422941 cagtagctca gtaggaagag cgtcagtctc ataatctgaa ggtcgagagt tcgaacctcc 423001 cctggagcac attttctttt tttgtgaatt aaacctcgaa gctcaacatt catgttttga 423061 gataaaaaaa ggtacttatt acttgtgtaa aagaaagttt ataatgatga tcttatttaa 423121 gtttatagta ggactttcta tgcatgtctt gtagaactat ttatgctgga ctcgccatta 423181 attagctcca gtgaaagtac atatcttctt tcttggacat tattatctct agtaatagtg 423241 atataaggat cggcattcaa caggtgatct ggtatttgcg gcaatccaga ttctggtcct 423301 gcgttttttt tcagttccat aaacctttca acgccaatcg gcagcaaatc agccggtaaa 423361 tgacgttgta gatcgcacat atcgaatgaa ttgatgtaaa aattgactat atcaaaataa 423421 gcttcattta cggatttctc gtctgtttca aataaagaat accttttact tgaccaattc 423481 ttattatcta gtaattcata tgctattttc aaaatggcca atgcaatgga atgttggggt 423541 atgactaaaa tagtttctag cttcaaagca tcataagcaa ttacccaagc cagattgcac 423601 aacttataat caaaggatag ctccctacca atttttataa catattcatc aatatgaacg 423661 taattgttga ctctataatc gaatgagcat gactctaata tccgaagttc tatttgaaat 423721 accctttttt taaaattttc caaaatgtcc gtattgattt taaccacatt cctcaatcgt 423781 aatgacaaag tacatatatc atttgttttt ttaattgtct caacttcttt acagcccaaa 423841 gtcaggcagc ttgtcgctac agtgtagcaa acctcggtct cgaagcgatt aaagaggtgg 423901 tatctttggt aaaagtatac tgctgtttct aaagtcttcc gtggaaattt cagctgaaca 423961 cacaagtcac ttagaaattt gaacacggca agttttttct ggttgtaatt tcgatagtcc 424021 gatattgtat tcttttgggc tctttgaatt tgccttttag acagaaacgg tctcgaaaaa 424081 aaaagctggg attcaaacgt gctaggcata tcaaagtacg taattttctt agttttgctg 424141 gctctatatc tcctctcgct ctatagatac agatatatat atatatatat atatatctat 424201 gtgtataaag acggctttca ggacagtact tgtttggatt tttgatcatc gcggattttc 424261 gcaatgcaag tataaagaga gcattacccg ccacacagtg attcttcagc aagttgtacc 424321 gaaaaggacc atttaggtac gtgggatcgc aaaggttccc aaacggtgtg catcaagccg 424381 tagacttcat gagtgctttc ggtgcagcaa aaagataagg acaaaaaata ctgaaggatg 424441 cgaggttcga actcgcgcgg acaaccgtcc aacagatctt aagtctgccg ccttagacca 424501 ctcggccaac cctccatctt atttaaaaat cctaggaaat agatgttata taagtcatac 424561 atcattgaaa acatcaaata ccgttccctg cgttgttcta cagaaaagcg cattagagta 424621 ggtcataccc tttaaaaaat gattttgtaa atgccagaaa gtaaacaaat atgcatttcg 424681 cctagctccc aatgtaaata gccataaaaa aggataaaat gccagattta gagtcagttc 424741 tcgttcttct tcttctctgt gttcaattgt tcaattgcat tgttaatcac tgaaattcta 424801 tgtttcaaat tggaatggca gactgaactg agaccttcct tactttctcc tctatcaaac 424861 ctaaatattc aatcataacc ttattttttc acttcctttt tcttactttt tttttttttt 424921 tttttttgta ttttggaagg aaagcagggg ggacttacca taagaaaagc gactctaaaa 424981 aagtgtattt tcttccaaag ttcagtaaag acagctggga agtatagtaa cagaggagag 425041 aaagcataag gagacctctt gctgcagttc acaaccaaaa atagcatatc tttactattg 425101 tcgctaacca ttgcgaaacg agctaaagca acagcaaacg aaatccctag gtcgaaatgt 425161 catcaaaacc tgatactggt tcggaaattt ctggccctca gcgacaggaa gaacaagaac 425221 aacagataga gcagagctca cctacggaag caaacgatag aagcattcat gatgaggtac 425281 caaaagtcaa gaagcgtcac gaacaaaata gtggtcacaa atcaagaagg aatagcgcat 425341 atagttatta cagcccacgg tcgctttcta tgaccaaaag cagggagagt atcactccaa 425401 atggtatgga tgatgtaagt atttcgaacg tggaacatcc aaggccgaca gaaccgaaaa 425461 tcaaaagggg tccatattta ctgaagaaaa cattgagcag tctttcaatg acgagcgcga 425521 atagtactca tgatgataat aaagaccacg gttacgcttt gaattcatcc aagacgcaca 425581 actacacatc tactcataac catcatgacg gtcatcatga tcatcatcat gttcagtttt 425641 ttcccaatag gaagccatca ttagcggaaa ccctattcaa aaggttttca gggtcaaaca 425701 gtcacgatgg caataagtca ggaaaggaaa gtaaagttgc taacctttcc ctttcaacgg 425761 taaatcctgc acctgctaat aggaaacctt ctaaagactc cactttatct aatcacttgg 425821 ctgataacgt gccaagcact ttacgaagga aagtgtcctc attggtacgt ggttcttccg 425881 tccatgatat aaataatggt attgcagata aacagattag accaaaggct gttgcgcaat 425941 cagaaaatac attacattca tccgatgttc ccaatagcaa acgctcgcac agaaaaagct 426001 ttctgctagg ctccacatct tcttcaagca gtagaagagg ttcaaatgtc agttcaatga 426061 ctaacagtga cagtgcaagt atggcgacgt cgggtagtca tgttctccaa cataacgtat 426121 ctaatgtttc tccaactact aaaagtaagg acagcgttaa cagcgaatcc gccgatcaca 426181 ctaataataa atccgagaaa gtgactccag aatataatga gaacattccg gaaaattcta 426241 actctgacaa caaacgcgaa gccacaacgc ctactataga aacacccatt tcatgtaaac 426301 catccctttt caggctagat acaaaccttg aggatgttac tgatattaca aagacggtgc 426361 cacccaccgc tgtcaattct acactaaatt ctacacacgg gactgagact gcctcaccca 426421 aaacggtgat catgcctgaa ggtcctagga agtcggtgtc aatggctgat ctctccgtcg 426481 ctgccgcagc acctaatggt gaattcacat caacttccaa tgatagatca caatgggtag 426541 cacctcaaag ctgggatgtg gaaaccaaaa ggaaaaaaac aaaacctaaa gggagatcga 426601 aatcaagaag gtcaagtata gatgctgatg aacttgatcc catgtcaccg gggccacctt 426661 caaaaaaaga ctctcgtcat catcacgatc gaaaggataa cgaatcaatg gtcactgcgg 426721 gtgacagtaa ctcaagtttt gttgatatat gtaaagaaaa cgttccgaat gatagcaaga 426781 ccgcactcga tactaaatct gtgaaccgct taaaaagtaa tttggctatg agtcccccaa 426841 gtatacgata tgctccatca aatttagatg gggactacga cacgtcttcc acttcctcat 426901 ctttaccgtc ctcatctatt agttcagaag atacatcttc ctgcagcgat tcctcttcgt 426961 acactaacgc gtatatggag gccaaccgag agcaggataa taaaacaccg atcctgaata 427021 aaacgaaatc gtataccaag aaatttacat cctcttcggt aaatatgaat tcaccagatg 427081 gtgcccagag ttctggatta ttactacaag atgagaagga cgatgaggtc gagtgccaac 427141 tggaacatta ctataaagat ttcagtgatt tagatccaaa gaggcactat gctattcgta 427201 tattcaatac tgatgacact tttacgactc tctcatgtac tccagcgact accgtcgaag 427261 agataatacc tgcacttaaa agaaaattta acattacagc gcaagggaat tttcaaattt 427321 ccctgaaggt gggaaagttg tcaaaaattt tgagaccaac ttcgaaacct attttaattg 427381 aaagaaaact tttacttttg aatggttatc gaaagtcaga cccacttcat attatgggta 427441 tagaggattt aagttttgtt tttaagtttc ttttccatcc tgtcacacct tctcacttta 427501 ctcctgaaca agaacaaaga ataatgagaa gcgaatttgt tcacgtagat ttaaggaata 427561 tggatctgac tacacctccc atcatttttt accagcatac gtcagaaata gaaagtttag 427621 acgtttctaa taacgcaaat atattcctac ctctggagtt cattgaaagc tcgattaaat 427681 tattaagttt gagaatggtt aatattagag catctaaatt tccttccaat atcactaagg 427741 cgtataaact agtatctttg gaattacaga gaaacttcat aagaaaagta ccgaactcaa 427801 tcatgaaact gagtaattta acgatattaa accttcaatg taatgagctt gaaagcctac 427861 cggctggatt tgttgaactg aaaaatctgc aattgctaga cttgtcttca aacaagttca 427921 tgcactaccc agaagttatt aactactgca ccaatctttt acaaatagac ctatcatata 427981 ataaaatcca aagcttacca cagtccacta agtacctagt aaagcttgcg aagatgaacc 428041 tttctcataa caaactaaat tttataggcg acttatcgga aatgacagat ttgaggacgc 428101 tgaacctaag atataacaga atatcatcaa ttaagacaaa tgcgtctaac ttgcagaacc 428161 tttttttaac agataataga atttcgaact ttgaagacac tttgccgaaa ctaagagccc 428221 ttgaaattca agagaatcca atcacttcta tatccttcaa agatttttat ccaaaaaaca 428281 tgacaagttt gacgttgaac aaggcacagt tatcgagtat tcctggagaa ttactcacca 428341 aactatcttt cctcgagaaa cttgaactta atcagaataa tttgactaga ctgccacagg 428401 agatatccaa gttgactaaa ttagttttcc tttcagtggc gagaaacaaa ctagagtata 428461 ttccacccga gctatctcaa ctgaaaagtt tgaggacatt agatctacat tctaacaaca 428521 taagggactt tgttgacggt atggaaaacc ttgaactaac atcgctaaat atttcatcga 428581 atgcattcgg taactctagc ttagaaaatt ctttttacca taacatgtca tatgggtcaa 428641 agttatctaa aagcctgatg ttttttattg ctgcagacaa tcaatttgat gatgctatgt 428701 ggcctctttt caattgcttt gtcaatctga aagtgctaaa tctttcttac aacaattttt 428761 cagatgtatc gcacatgaaa cttgagagca ttaccgaatt gtacctctcc ggtaataagc 428821 tcacgacatt gtcgggtgat acagttttga aatggagctc tttaaagact ttaatgttga 428881 atagtaacca aatgttatct ctgcctgcag aattatcaaa tctctcacag ctaagtgtat 428941 ttgatgttgg agcaaatcaa ttaaagtata atatatcaaa ctatcattac gattggaact 429001 ggaggaataa taaagaacta aaatatttga atttttcagg aaatcgaagg tttgaaataa 429061 agtcatttat aagtcacgat attgatgctg atttgtcaga tctgacagta ttacctcagt 429121 taaaggtact aggtttaatg gacgtaactt taaatactac caaagtaccg gatgaaaatg 429181 tcaatttccg tttaaggaca actgcatcaa taataaatgg gatgcgctac ggtgttgctg 429241 atacattagg tcaaagagac tatgtgtcat ctcgtgatgt tacctttgaa agattccgcg 429301 gaaatgacga cgaatgctta ctatgtcttc atgatagtaa aaaccaaaat gcagattatg 429361 gccacaatat atcaagaatt gttagagata tttacgataa aatactgatc agacaactgg 429421 aaaggtatgg agacgaaaca gatgataata taaaaactgc acttcgtttc agttttttgc 429481 aactgaataa ggagattaac ggaatgctaa attctgttga taatggtgcc gatgttgcca 429541 atctttcata tgcagacttg ctaagtggcg cttgctctac tgtgatatat atcagaggga 429601 agaaactctt cgctgcaaat ttaggtgact gtatggctat tttatccaaa aacaatggtg 429661 actaccaaac gctaaccaaa caacatctcc caacaaagcg ggaagaatac gagaggatca 429721 gaatatctgg cgggtatgtc aacaatggaa aattagatgg tgttgtagat gtgtctagag 429781 cagtgggttt ttttgatttg cttccccaca ttcatgcttc tcccgacata tctgtcgtga 429841 cattaacaaa agcagacgag atgcttattg tagcaacgca taagttatgg gaatacatgg 429901 acgtggatac agtttgtgat atcgcgcgtg agaatagtac tgatccactc cgtgccgcag 429961 ctgagttgaa ggatcatgcc atggcttacg gctgtacaga gaatattaca attttgtgcc 430021 ttgctcttta cgagaacatt cagcaacaaa atcggttcac tttaaataaa aactctttaa 430081 tgactagaag aagtactttc gaggatacta cattaagaag acttcaacct gagatttctc 430141 cgccaacagg taacctagca atggtcttca ctgatatcaa aagctcaacc ttcttatggg 430201 agctattccc taacgcaatg aggaccgcaa taaaaactca caatgacatt atgcgtcgtc 430261 aactacgaat ttacggtggt tacgaagtaa agacagaagg agacgccttt atggtggcat 430321 ttcctacgcc aactagtggt ctgacatggt gcttaagtgt tcaattaaaa ctcttggatg 430381 cacaatggcc ggaggaaatt acctcagttc aagacggctg ccaagttacg gatagaaatg 430441 gtaacattat ctatcaaggc ctatcagtta gaatgggtat tcattggggc tgcccagttc 430501 cagagcttga tttagtgact caaagaatgg actatttggg gccgatggtc aataaggcag 430561 caagggtcca gggcgtcgct gacggtggtc agattgcaat gagtagtgat ttttactctg 430621 aattcaacaa gataatgaag tatcatgagc gagtagtgaa gggcaaggaa tctctcaagg 430681 aagtttatgg tgaagaaatt atcggagagg ttcttgaaag agaaattgcc atgctggaaa 430741 gtattggttg ggcatttttt gactttggcg agcataagct aaagggactc gaaaccaaag 430801 aactcgttac tattgcgtat cctaagattc ttgcttccag acacgaattt gcatctgaag 430861 atgagcagtc aaaattaatc aatgaaacga tgttgtttcg tttaagagtc atttcaaaca 430921 gactggaatc tataatgtca gctttaagcg gcggatttat tgaactagac tctcggacgg 430981 agggaagtta tattaaattt aaccctaaag ttgaaaatgg tattatgcaa tcgatttctg 431041 agaaggatgc gttgttattt tttgatcatg taattactag aatcgaatcc agtgtggcat 431101 tattacattt acgacaacag aggtgttcag gactggaaat ttgcagaaac gataaaacat 431161 ctgctcgaag caatattttc aatgttgttg acgaactttt acaaatggtt aagaacgcaa 431221 aggatttatc aacttgagtt ctgttcgtaa attatgtacc accctgttac tcgtttcata 431281 ttcacgctag agaagtacct cagcttacta gatccattca cacattgcaa gtatactaaa 431341 actatataaa atttaagtac gtaaactctt tacttattat tatcttcaat gtcatcacgt 431401 acttaattat gttaaatata gattgtgtat aaataagaaa taggatctgt tttgaaaaat 431461 tggccaaaaa ggcagattta ttaagcctat agagataagg ttcttgccat ttttcataca 431521 tttactgttt tctcttgaat gactataata ttgccaaaat tgcctcgaat atgttgtttc 431581 atctcctctc atatttggct ttctaagtct tttagttgta ttggtgattg ctccaattct 431641 gaatgattac tatgctgctg actaggcgta accaatccaa cttctccttc attaggatca 431701 accaagccct caaaaaaggt gtctctaagc tctctccatc ttgttgtcca tgtccccaaa 431761 aatattagta ttaaagatga taaaatttga agaaaaaacc aagaaaaaga aggaaatttc 431821 cgagtataga ggaacaccac aataaaattg atggcatgta tagtgatagc aaaatcccat 431881 gcgagtttac tccgtccaac gataacagtt aagaaaaaaa cacatattaa tgaatccaga 431941 agccataaca gtgagattga taaaccgtat gcgttcgtaa agtcgatatt ctcccaagaa 432001 aacagccatt ccttgatatt gagatcatat cccgctagct tcgcccaaca ataaaaaaga 432061 acgatcgctg tggtgtaata aaaaatctgt aaaagaacaa tttgaagtcc aatcttactt 432121 ggagagagag aatcttgttt gaagatctgg gaaggtttca actcattcgg cactcgcaaa 432181 taccttctta tcgaaaccat gttacagtaa ttcaaatgcc tattttttat ctcacttcta 432241 tgtgtaccct tccttagcct tcctaaagat catctcttaa catgaagtta cagaatatta 432301 ccgtgaatat cgcgagctac gaatattttg ggtggggaga tatttattca tgattagcct 432361 tgtcctatag tgttacaatg gagcaaattg ttcaccgtta gtattttgaa tacgacaata 432421 ttaaatgaat aatagcgcct atctcttgtt acgtttggcg atttgtatac cttgttaaat 432481 aaactgatta aaagccgggt tatggccgta cacaagttat tagaaagcaa atacacttcc 432541 ttatatctgg tcacctagtt aataaaagga agtctttaat tttggcaaaa accactatat 432601 atattagtca acaactgaaa tattaccaga atttgtctcc taaatgtcgt tcagcggaaa 432661 aaaatttagg tctagaagac agcagctagt atatgaagca tctttagcgg ggcgatacaa 432721 aaaagcattg agtaagcacc cctttctttt ttttggttta ccattttgtg caacaatagt 432781 attgggttcg ttttggttgt caagctttac agcgatcaag tacgagcaag gcgatcgtaa 432841 agttcaggaa attaatgaag aggatatctt gaaaataagg aagaatcaaa gggaatttga 432901 tattaaagaa gaatattatc gtttacaagg tctttctgaa gaggattggg agcctgtgcg 432961 cgtcgctagg ttaaaggatg aatctgagaa tgtctggtaa cattcaaaac gtgaacatct 433021 ttgttattct tctgtcctta aactactaaa caaaaaaaac tatgaccatt gattgtgcaa 433081 agaaaagacc acgagaatgt ctaggaaatg attgtaaata cctttattca ttggaaaatt 433141 cttatctata aaacttataa aaaattaaat actgaattta ttgctctgca tcataaggta 433201 tatatcattc aaacgtgaac tcagttagtt acgttcatgt tcaaagtttt taagacaaaa 433261 actcccatta gtgcggtgaa aatatagcaa gcaatagaca gaggcttctt gaaaaaagag 433321 cttttcgggt agtcgtactt tatcaagact tggccattgg caacttgact aatcaaattt 433381 ctgtaactga aagttaattt aacgtgacct ttatttaggt caaagtatga tttctgggtt 433441 tctatagaaa catttgtaaa agggactgga gaatcaatat cgaatatttc ggccccttcc 433501 ggaagaaata ccgataattc aacattatca tatacagtgt ccggtgggcc gtttagaatt 433561 gggatagaag caacgaattt ctcgtctgag ccagaggata catgcaagaa atcggacaat 433621 ttattagtcc aaccgacagt aaaattgtag ttccaacctc caaagattgg gaatcttggt 433681 cttataaaga aatggtcacg ttctgcatgc gacgtggaaa caaggccaac caaatcagtg 433741 aaataatgat cagtagctcc ctcaggcagg agcatgtcta agacagtaac aaagtgagtt 433801 tgtctcatat tctgagtttg aatctgtttc attaattcta atcttgaaaa tcctttagac 433861 agttttgcgg ctttgtttgt taattcataa tattcctcaa attgtattgt ggaagcccaa 433921 tgagaaagcc aaatatctct tctcaaattc actacctgat tcaatggggc attgtgggaa 433981 taaacaattg ctaaggtttc gtttgaagaa aatctcggaa tatcttccca aggcccaaac 434041 tcaaaagagt ttccattagc ttttcccagt aaactctcgt catttggggg gtggtactcc 434101 tcaaatgatg agctaccaat cagcgtaaaa gaggccttct tggtatcgta agcagaaagc 434161 ggcaatctgt tcgtttccca caataggtgt tgttcttctg acattccaac gtgctcagga 434221 taaggaatac ctacggtatt atagaagctc ttaatcacta aagaaacttc ttcctgaggg 434281 gaaattgcat ttggaaattg aatgatcccg tatctaattt cactttcacc atcgtcacca 434341 ggtgctgtag tcgaattggc aagtaattgg ctatttaaaa aagttgcctc gttggtaaaa 434401 taggctgaaa aaaaggaaac tttactgaag atgccactct caaaggctgt gaagtattca 434461 gtcgcaggtt cgcttgctat gtttttgata gttatttcga ttgtttctga aatataagcg 434521 tttgacacgt ctattgtcct cttataatca acattctccc aagtcgcagg tggctcgtat 434581 tgggcagcag aagacacgtt gaaaaaacat aggaacaatc ccacaatcca agagaaccaa 434641 acctgcctca ttttttcagc accaatattt tgtagtttgc gtcttgttcc gagctaaaga 434701 agcaatcggg tacttgtcaa agaagtagct tgcttaataa aaagcaaaca ttaatttgtt 434761 ctgcatactt tgaacctttc agaaaataaa aaacattacg cgcatactta ccctgctcgc 434821 gaagaagagt aacactaacg cattctatgg gcaattgaag acagtattca gtacaagaca 434881 tagtccgttt ccttgagtca attcctatag cattatgaac tagccgcctt taagagtgcc 434941 aagctcttca acaccgatca tttttgatga tttggcgttt ttgttatatt gatagatttc 435001 ttttgaattt tgtcattttc acttttccac tcgcaacgga atccggtggc aaaaaaggga 435061 aaagcattga aatgcaatct ttaacagtat tttaaacaag ttgcgagacg gtgtacaatt 435121 acgataagaa ttgctacttc aaagtacaca cagaaagtta acatgaatgg aattcaagtg 435181 gacatcaatc gtttgaaaaa gggcgaagtc agtttaggta cctcaatgta tgtatataag 435241 aatttttcct cccactttat tgtttctaaa agttcaatga agtaaagtct caattggcct 435301 tattactaac taataggtat cttataatca cctaataaaa tagtatggcc gtgacattta 435361 aggatggtgt gatactaggt gctgattcac gtaccaccac tggtgcgtac atagctaacc 435421 gtgtgacaga taaattaacg agagtacatg acaaaatttg gtgttgtagg tccggttctg 435481 cagcagacac gcaggcgatt gccgacattg ttcagtacca tttggaatta tatacttctc 435541 aatatggtac cccctccaca gagactgctg cctcggtgtt caaagaatta tgttacgaaa 435601 ataaagataa ccttactgct ggtataattg tggctggtta tgatgacaaa aacaaagggg 435661 aagtatatac tattccattg ggtggctccg tccataagct gccttatgcg atagcaggat 435721 ctggctctac tttcatatat gggtattgtg ataaaaactt tagagaaaat atgtcaaagg 435781 aagaaaccgt agatttcata aagcattcgc tatcgcaagc cattaaatgg gacggatctt 435841 ccggtggtgt tataagaatg gttgttttga cagctgctgg tgtggaacgt ttgatattct 435901 accctgatga atatgaacaa ctataataga ccccaaaaga acaaattctg agtgattact 435961 tctctttata tttgttaaca aatgcctctg gatctacact gatataacat ataatagtct 436021 ataacctctt tctctttttc tcttcgcttt acgctttttt ctctaactgt tagaacgaca 436081 aagtatctca gaagggaatt tcgtaagcaa gatattttac gactaatcat ttttttgttg 436141 tataaaaacg tatgtgagat tgattcacta attcttcgga gtcctggaag gcttacctta 436201 tctatgcatt cgtacagttg tgtgcaatgt taaaaatggt gactgtatct acgtatctat 436261 aaaaaaaggt taactaccgg aaaatcattt cttctcgtaa agtgtatatt taggttcgga 436321 aatcataaac attgtttttt tgtgtttttt atttttaaat aaaaagaata aatattttat 436381 attaaaaaat aaattttaaa gtaaattaat tatttaacac gtgattaagt tactctaata 436441 taatcctatt taataattag tagagttgtt gagaacgagt ataatattat ttttttttta 436501 tttttttgta ggttctttgg ccatcctaaa tagaataagc atccacaaca actaaactgg 436561 tattttgtta tacacaacgc gtcttggtta ggcatctgtt ttgttttagc tattgttcat 436621 cgcgtttttt tttttcttat ctcttttacc gaggggcgaa aatagcgata gatcgagaat 436681 ataaataaat aaaatattgt tgtgttgtgt agttctaaag aaaaatttta cagtgaaaag 436741 gtaacaccgg ggagtcatta cgtagactta cgtattctgt ataactgatt ccgagacgca 436801 aatgcctgag caagaaccat tgagtcccaa tggccgtaag cgctctgagg ttcactatat 436861 ctcaatccca ttgaacagag gttccgcatt ctcaccagat gattctgtat cacagtttca 436921 gtctgacggg ttcatgacac gtaggcaatc catattggac catcctgtgg gctcatttaa 436981 gggagttaat tctttaagtc gatttgcgac ttcgttgagg agagccaatt cgtttcgtaa 437041 tatcgagcta aatgcggata atgaaagatc ctttttcaaa gagagtaacg atgaaaccta 437101 cgatccggat actttagcac cagctttgga cggtagaaga ttatcagtaa ctttaaataa 437161 tgctggtcgc ccgcgcatta ctaatttggc taacaacgat agagttagta cagccagcat 437221 ggctattcac gatgatgatt atgggtccat ccaaaattca acaattgggg attctgggtc 437281 aatattacgc cctactgcct ccttaacaga aatgatgagt ggtggagcgg ggagaaggtt 437341 tacaaataat gacatggatt caattgtagt gaagagagtg gagggtgtag atggtaaggt 437401 agtaactctt cttgctggtc agtcgaccgc tccacagacc atattcaact caatcaatgt 437461 actgattggt attgggctcc tggcgttacc tcttggtttg aaatacgccg gctgggttat 437521 aggacttact atgcttgcaa tcttcgcctt agcgacattt tgtactgctg aacttttgtc 437581 taggtgccta gatacagatc caactttgat atcttacgcg gacttgggat atgcagcatt 437641 tggtacaaaa gggcgcgcac taatttctgc tcttttcaca cttgacctac tgggtagtgg 437701 ggtgtccttg gtgattctct tcggagattc tttaaatgct ctatttcctc aatactccac 437761 cacttttttc aaaatagttt cattttttat cgttacaccc ccggttttta taccattgag 437821 tgttctatct aatatctcgc ttctgggaat cctttcaaca accggaactg tgctagtcat 437881 ttgctgctgc ggactataca agtcgtcttc tccaggttca ttagttaatc cgatggaaac 437941 gagcatgtgg ccgatagatc taaagcatct ctgtttatct ataggtttat tgagtgcctg 438001 ctggggagga catgcggttt ttcccaactt aaagacagat atgaggcatc cagataaatt 438061 taaagactgt ttgaaaacta cctataagat aacatcggtt acggacatag gtactgcagt 438121 tattggcttt ttgatgtttg gaaatcttgt taaagatgaa attactaaga acgttttgct 438181 gacggaggga tatccaaaat tcgtttatgg tctgatttca gcgcttatga ctatcattcc 438241 tatcgcaaag accccattga acgcaagacc tatcgtttct gtattggacg ttctgatgaa 438301 tgtgcaacac atagatgaag cggccagcgc cataaaaaga agagctgcga aaggccttca 438361 agtattcaat aggatcttta ttaatgttgt cttcgttttg atagctatta atttccctga 438421 atttgataag attatcgcat ttctgggggc cggtttgtgt tttacaattt gcctaatttt 438481 gccgtgttgg ttctatttaa gattgtgcaa gacaacaatc aaaccatggg agagagtggc 438541 ttgtcacgta accatatgta ttagtgtcgt gttgtccaca ttaggtgttg gtgctgcaat 438601 tatttcataa tcgacgaggg gcatacttac tctacttaaa attcatttac attagctctg 438661 tacttctgat aatgaaaaac cattgcgtaa tatacatatt ttcgtgtaga attatttcca 438721 taaaatattc accgcctttt ctgtactggc cgccggcatg cgagggaagc agaaaatttt 438781 caattttgcg atgagctctt gaagaaacag tgttttgtta tgaataaatg atgtgtgcac 438841 gaaagaccca aggaaagtcg tataatgtca gaactctttg gagtattgaa atctaatgct 438901 ggcagaatta ttttgaagga cccctccgcc acttctaaag atgttaaagc atatatagat 438961 tcagttatca atacctgtaa gaatgggagt attacaaaga aagcagaact ggacgaaatc 439021 actgttgatg gtttagacgc caatcaagtt tggtggcagg tcaaactagt tcttgatagt 439081 attgatggtg atctaattca aggaattcaa gaactcaaag atgttgtcac gccttctcac 439141 aatctctctg atggtagcac cctgaactca tcatccgggg aagaaagtga actagaggag 439201 gcagaaagtg tttttaaaga aaagcagatg ctctctgctg atgtttctga gattgaggag 439261 cagagtaatg atagtctttc cgagaacgat gaagaaccta gtatggatga cgaaaaaacc 439321 agtgcagagg cagctagaga agaatttgcg gaggaaaaaa gaatttcttc tgggcaagat 439381 gaaaggcatt cttcacccga tccttatggt atcaatgata agtttttcga tctcgaaaag 439441 ttcaataggg atactttagc tgcagaagat tctaacgaag cttctgaggg gagtgaggat 439501 gaagatatag attattttca agatatgcct tcagatgacg aggaggagga ggctatttat 439561 tatgaagact tttttgacaa acccacaaaa gaacctgtga agaagcactc tgacgtaaaa 439621 gatccaaaag aagatgaaga attggatgaa gaagagcatg attctgccat ggataaagtg 439681 aaattagact tatttgcgga tgaggaagat gaaccgaatg ctgagggagt gggagaagcc 439741 agtgacaaga acttatctag tttcgaaaag caacaaatag agattagaaa acagatagaa 439801 caattggaaa acgaagcggt tgccgagaag aaatggtctt tgaagggtga agtaaaggca 439861 aaggatcgtc ccgaagatgc attgctcact gaggaacttg aattcgacag aactgcaaag 439921 cctgttcctg ttataacaag tgaggtcaca gaatcattag aagatatgat tagacgaagg 439981 atacaggaca gtaactttga cgaccttcaa agaagaaccc tgttagacat cacacgtaag 440041 tctcaacggc ctcaatttga attgagtgat gttaaatcct cgaagtcgtt agcagaaata 440101 tatgaggatg actacacacg cgctgaagat gaatctgcat taagtgaaga gcttcaaaag 440161 gcacattccg aaatatcaga actttatgct aacttggtat ataaattgga tgtgctttca 440221 tcagtgcact tcgttcctaa gccagcaagt acttctttgg aaattagagt tgaaacaccc 440281 actatatcga tggaggatgc tcaacctctc tatatgtcga atgcctcttc tttggctcct 440341 caagagatat acaatgtcgg taaagcagaa aaggacggag aaattcgctt gaagaatggt 440401 gttgcaatgt ctaaggaaga attaaccaga gaagataaaa acagattgcg cagggctttg 440461 aaaagaaaaa gatcgaaagc taatttgcca aatgtaaaca aaagatctaa aaggaatgat 440521 gttgttgaca ctttgtcaaa agccaagaat attactgtta tcaatcaaaa gggtgaaaag 440581 aaagatgttt ccggtaaaac gaagaagagc agatcagggc cagatagcac aaatataaaa 440641 ctttgaacac gccgaagaag acttagtttg tatttaggta aaaaattatt tcttcataac 440701 tctgttcacc cagcattttt tatggaatat cgaccttgta atgtcattaa ccccttaaag 440761 gaccacttaa agaaaatgaa gtgcatcatg aaatattcat gacgagatgc ggaacatata 440821 cactcataaa taccagaaga atgtgctgaa taattttttg ttggtaattg gctgtcattt 440881 aaagtatcgt tgaaacaaga ggtattggaa gatagctaat tttagtatta tttatgacgt 440941 tctttcctgg ataaatgtag atgtatatac gtaataaaat gttaattagt aagttatatg 441001 ctttccatat aatgttctat cttagtctgc ataacttgtt tgcttgtttt tgtttctaac 441061 gcttctccat actgggctaa gagatttttt attttttttg cagcagtcgg ccctgatatc 441121 agcttttctc ctagtgcgcc atcaaagatg accctggcaa aatcagcatc atctctggat 441181 aagaatgcta aaatgagcga ttcagttaat acgtcacttt cagcaagatc tgtgtactta 441241 tctttctctc gtttagcagt agatatatta gaattgtaaa ttttgagaga tagatcaata 441301 tttgctttcg cgttagcaac aattaacaca ctttgaattt tactctctag tttggaatca 441361 aagtcttctt taataaaagc ttcagcgtat tgtagcattt tttcattact gcttttataa 441421 ccctggcagc agagcgttaa aaacgcttca aacattaagt cgtcctcatt atttttgaat 441481 tttaagagat attcgtcgta taatttaaaa aatagagaaa ctttaccttt gaaagcgcca 441541 attaatctta acagcttgtg agctaattcg aaatccttct tgtctatgtt tcttttttgg 441601 atctctaaaa ataattcttc gaatgaagtt gcagttttgc gtacactcca attcggaaat 441661 tcgaggctcc aattatcatg acattgtgat ttaacaatat ctatttcttc ctccaacttg 441721 ctaataattt ctttttcttc ttcagtttgc tgaattttct cgttttcgcc cagaacagtt 441781 agacacttgt gtagtactaa tggatcagct actatattat caagcgaata aaaatcataa 441841 agttcacaaa tttggtattg tgtcatttca ctgacatact tatcaaaaaa gctcagcggt 441901 attttatatt tgagtacaga acctaaaaca ttgggaattc cgttgtccac tatgtaaata 441961 aggataggtt ccacgagctc tgaaggcaaa ttataatttg aagaaaaatg gttgattaaa 442021 taaagacatc taacgaggtc ttgataagtc agactctttt ttccatcaac cttttctgcc 442081 ttgtcaaact tgataatttt ttctaagacc acttccatca gttcatcagg aacattttcc 442141 attgaggcct tgtattgtgt aaaaagttcc caagagcttt gtactcttcc tggattattc 442201 ctaataattt gtttgatggc gggaagtgaa ggttttaaat caagatcacg caaattattt 442261 gagtgaattg ttgcaacgcc gtagtcaaga tcacttaagt tttctatcat catattgtgt 442321 accatggccg catccttttt aggaacctct aatttgttta aactttcgat aacattctgc 442381 gatagagagt atgggtcaat ggtggttata tcttcaggca aatgatgacg aattggatcg 442441 aaagaagggt gacgtagaag ctttttgatt atgttctttc tatttgaatg agatatgaga 442501 gagtaaaacc tcttgttaga taacgtagcc gcagaatgaa gagagcgtaa cattattgaa 442561 tggcggttag ctgttaagca tttgaaaaag tagctctcat cgaactcttt catggtgatg 442621 aaattttttc atctacttac ttaatcagtg gtctactgaa acagccttcg ggtaatgaaa 442681 cgagcggtaa cgctcacaaa tttttctttt tacgaacaaa atataaattt aatactatga 442741 taaaatctgc ggtgagacgg aaaaggataa gaactagaaa agtattatta gagttaagat 442801 atgaactgtc catttaacta tggttgaaga aaaaaagagc caggatgaaa attatgaaca 442861 ataatttcgt atatttcgac tcaatgtact aactgtacag tacccgtttt agaatagcag 442921 gtacgacaaa agcagaaaaa tgatcgaacc gagctcagct gagaaaaata tagacgcttt 442981 accttcatag gttgaaatca tgagagaagt tgatgtgaaa ttctgttgga taccggacaa 443041 ttggcttcct gatgcagaag aaggatatgc gatcaaggat gacactaaaa aggtgtcaat 443101 tttcgttccc tgagatgaga ctgctgtttc actaaaagaa ttaaggccaa ctgaagatgt 443161 tgtcaaagcc gtgtgctcaa agtaacccgt atttttcgtt ttgatatatg tattagatgt 443221 tggcacagaa ggcgtaaaac tggtgcttag taatgttttg cttacggaga gggacgatac 443281 gagtggggaa gacgtataag atgagggact ggatggctgt ttgctgctgc agaaggaatt 443341 taaggagttt ctcgtggcat ttacaaaagt gggctcttca gatggaacag cagcagtatt 443401 cgtgatattt tcagtgtgca cattgacaat tgaagcatct gaggtttcaa atactgctga 443461 tgaagagatt attggtgtgc tgttgattgt tgcgaaagaa gaggatgtaa attgcgagat 443521 gtaagtattc atagcgcctg tccatccagt tgttgaggtt ggagcggcta caacggtcga 443581 agctgtttct ctgctaatgg tttccacatc actaatcact tctgatgtgg tgtgaatatc 443641 tgttcctact gtgatatttg agtcagtaga atagatactg gtttgtgcaa ttgtcaggct 443701 ggtagtagca gttggagaca gttttgtgct ggtagtcacc acatggctga tcacttctga 443761 tgtagttcga ttgcctgttt ctactgtgga aatggatcca gtggaatacg cactagtgtt 443821 tatacttgtt aaatcagtag tagtggttga gataaaagag cttttggcgc tagctgtacc 443881 gaggttccga ccctgataaa caataaattc cctagtagtc gagaattgcg tagcgtacgt 443941 agtatttgct atggtatcaa ggcatgtgta ttgaaattct aacgcatgat ctattgtgtt 444001 tacattagcg ggtagagatt gtaatgcatt aacccataac atttccccat catatagttt 444061 ttcgtcaagt gtaatccaca gattactacc aaaacaagtg acgtcagcat tggtatcatt 444121 gtaactttgc gggaaccacc aatcattaaa atcattggat gaataaacct gaactgaaga 444181 acaatccaaa tcgacattgt tattggaact gtcgtaatca atcttctcag taccacccag 444241 gaaatatccg tttggacaat acatacccaa atgataactt tcaaaagaac cgtaaccagt 444301 tgaacgccca gagtgaaaaa cattctctgt aaaagcagca ggatcgaaat tcaccacatc 444361 tgacatttga ttaccaagtt taacaagcat tggcccagat ttgaaaaact tagcgttttc 444421 taactcatat tcatagctgg aaccaccatc actaaaattt agcgaaaatg ttatggatcc 444481 atcaatcgta ttataggagg acaggtcatt ttgagcagta catgtgaaag tagtattttc 444541 atacaagtat gcagcctgtt gcgaaacata gcatttgaaa gcctcagtac catccgctaa 444601 ggaaatagta gctgtttgcg atgagtttaa tagcttaatc ctataaacat gtggcattga 444661 taatgtgaat tcatcgccct ccctaatgga agacgcatct gcaatactaa aatcaaaagt 444721 ggcagtccaa ccttgatcag gttgtttatt tgcagtcagt ggagtaattt ctaaattgga 444781 aaatgtgata tcgttgatat ttatagcaga ggccaatgcc aaggaaaaaa gccacagaat 444841 aattttgaga aaagtgaaca ttttgaaaac tggcgaattg ttgttccttt tgtgctgact 444901 atattaagcg aggcgactga tataaggaag atatgagaat ggacgattac tagaataaat 444961 agagggcatt tcgcatattt atagtatgct aaaaggaatc tttttttgat tcacatggct 445021 ttttttttag aagattgcat ttcgttacat gatcaaacaa ttccattgta acgtttttgg 445081 gaatatttaa gcgccgttac tgaagaatga agtgacataa agctgccatt gtatggtaaa 445141 acaccaaagg cgagtaccct tagcatttcc ttatcgagct ggagcggctt ctaccttcct 445201 aattaggtca tcaatgacct gcaaaacaaa gcgaaatgga caaaggacct acacttgcct 445261 cgtggcggga aactgcatgt agttgttcaa tgtttcacca ctcagtgttg aaactgttta 445321 ctccattgaa ttgaggtgac gatggataaa ctttctttat tttttatatt tttttataat 445381 ttaattaacc taaattgagc ctaacagagg aatttgaaac aacacaatag aaaacatgag 445441 tttcaaaagc taaatatggt attactattc atagtggtct tggtaatgaa taatgcatat 445501 gtatactctt cttaacgcct tatcttatgt aaccatacac ttttttagta aggtttcaat 445561 taagctacta ttctcaatta aatactgctc tgagctagat aaggcctatt gaagttggag 445621 gattagatgg atagaaataa ggaactaaat cgtcaagttc gaaagcctat tcccattcat 445681 gcatatcact tacctttcct taatcatgat ctctttagtg ccatcagaac tattttctta 445741 acatcgcgat tctgtcttcc gggtatcgct ccaaaaatgt gcgaggaaat aggagatcgt 445801 tcaaatcatc aacttttagt attgggtatc aaagtatcgc agcctggaaa cagaattaat 445861 ctactgcaca agaagggaat acagcaagaa cattcacttc attaatagga cgtatttcgc 445921 ttatgtccga tcaaaaagtt tttgccagat ataaagcaaa tgaaatcgtc acagatctgc 445981 aacattttgg agtaaaaaag tttaaatcga atataacaag aaggaaaaat gctctgagaa 446041 aaattatcgc caatttggtt ctaggaaact atggcgaaat gtccgttctg ttttctgagc 446101 tcttgaaatt ttggcaaatt gaagatgatc tagaagtgaa aagaatttgc catgagtata 446161 ttagggtgat cggcgcatta aaacctcagc aggccagaga ggctttgcca tttataatgg 446221 acgatttcaa aagcagagat gaaaagttac aaataatggc actaagaact ctggtattag 446281 tcccggtgaa agagctatct gatcaggcct tcgactgtat catttcattg gtaaatcaca 446341 agtctccacc tgaacaagtg acgaggacag caatttacgc actgttggat ttagatgaaa 446401 ttgatcatga aagggtattg gggttatcaa gcattctaca tgacattgta aaagcacagt 446461 cgagctctcc agaagtcatt gtagctgcat tacatacttt atattccatt cacgaaaaaa 446521 acgctaacat ggaacccttc aggattccct tggaactcgc ttttgacatg ctagagcttt 446581 tacccgaatt aaatgagtgg aataaggcta ctgttttgga agttttgacg acttcggttg 446641 tgccgcagca ttatttggat acccatgaaa tgatcgaact agctttaccg tacctgcaac 446701 aagtaaacac atacgtagtg ttgaactctt taaaattcat catgtacttg ttgaattatg 446761 ttgacgtcat caaagaaact ctagccgaaa agctatctaa ctctgtaata gctttgttag 446821 ataagccgcc tgaattacaa tttttagtat taagaaacgt tattcttctt ttattgagta 446881 gggagtcatc tctactcagg ctagacattt cgtatttttt catcgagtac aatgacccca 446941 tatacatcaa agacacgaaa ttagagtgtt tatatctttt agctaacaag gaaacattac 447001 caagaattct agaagagttg gaacaatatg ctacagatat tgatattcaa atgtcaagga 447061 aatcagtcag agccattggt aatctggctg ttaagctaga tgaagactct gtacacgatt 447121 gtgtcgctgt tctactagat ttgttagaat tcggtgttga ttatgtcgtc caggagatta 447181 tttcggtttt cagaaatatt ttgaggaaat atcccaataa ttttaaagca aacgtaacag 447241 aactagtcaa acacactgaa gttgtacagg aacctgaatc aaaaaacgct atgatctgga 447301 taataacgca atattcggat gtaattccaa actacctgga gttatttaga gttttttcct 447361 caaacatgtt tagtgagacg ctagaagtgc aattttccat tctgaactca gcaataaaat 447421 tcttcatcag aagtcctaca aaggaaactg aagaactttg tatggattta ttaaaaggat 447481 gcatcgatca cgaaaataat cctgacttaa gagataaaac actgatgtat tggagattgc 447541 tgtcattaac gaaaacgtct cgtatatcaa acgcgataac ttttgaatct ttaaaatcag 447601 tactggacgg agagttgcca ctaatagaaa tgaacacgaa attagatccc accgttttgg 447661 aggaattgga gctaaacatt ggtacaatag tatcgattta cttaaaacct gtttctcata 447721 tctttagatt gaataaaacc aaactgctac cacaaagtcc tattttgaat ccaaacaaag 447781 acctcttgcc agttgtaggt aactcatttc ctccaactgg agctaatagg gaccgtcaaa 447841 attcagaaag ccagtcctcg acgaagtcca gaaagactgc tatgatggat gattatgata 447901 agcccgctga aaaaattaat cagttgaaag gtaagcgtaa atctagttca aacaacccct 447961 caaaactatc acggaaaccc tcaactttat taagaaaact ctctatgaaa cggccctttt 448021 cgtgactgca aatgatacta attcctgtat ttaaatatac tcatatttaa cgaacaatta 448081 tgatgaatga aaaaacctga tataatagac ttaactaagc gatcataaaa aaattcaaaa 448141 agttatttta taaaacaatt cagatgttaa actaaagagt taatgtaata tatatacaat 448201 gaactgcgtc ataaattccc atagttcagc tcatgggaca ttatctactt ataaagacgt 448261 ggcttggcag catttcatat ataaggctac tgaatgtaaa tttttcttcc attgtctttc 448321 ccgtgtcccg agaactcaat tcaagcactg ttcttgggcg taataaacct tccggtacta 448381 ctaaaatcag acaaaggcag gaagcctcga tttgaccttt taacgggtaa agctctaaaa 448441 gttgctctct gctccatatt ctcgttttcc gtcatttcag tatctttttc ccctgcctcc 448501 cttacctaaa gcttcctctt cggcggctag taattggtct ctttcctttt tggctcttag 448561 cttctctgtc tttttttgtt ccataatcag cttcttctgg ttaggggttc tcgcaccttc 448621 ttcccacctc tgagcttctt gagcttctag ttgttgtttc tctagttggt ccttttcgta 448681 agcttgccta cgttttcttg ctcttcctgc tgccactttt ttggcagttt ctgagtatct 448741 cttgccagta ttatgcatgt tcgcttcttc actatgtttg gtggtttcta atgacaacta 448801 tgcggttagc aaacttccaa aaggcggtta ataatacgac tacacattat cctatatata 448861 tatatatatg tacgcaagtg cttagattgg aaaaaagggt gcaacattct cgattgttct 448921 atttcagcct gttgatatca atctgtcgtt caatgctttg tgggtgtgct ttacccactc 448981 ttatacagta gttaagtggc aaaaagggtg tcaaagggaa aggaaaacca gaggaaaagc 449041 aaaatagccg ccaatactaa ctctagattt atatcatgtt atacgattaa tcagacgcgt 449101 ctgattaatt tcaaaagtta aaatataaac tatttttgaa atcccattgc aataagcgaa 449161 ctatagctga atctttcctg caaaaatgga agtgaagggc aatggacgca ttgttaacaa 449221 agttcaacga ggatagaagt ctccaagatg aaaacttgtc ccaaccacga acgagagtaa 449281 gaattgttga cgacaatctt tacaacaaat cgaatccatt ccaactatgc tataaaaaac 449341 gtgactacgg ttctcagtac taccacattt atcaataccg tctaaagact ttcagagaac 449401 gcgtcttaaa agaatgtgac aagagatggg atgcgggctt taccttgaat ggccaattag 449461 ttctaaaaaa ggacaaagtg ttagatattc agggaaacca accatgttgg tgcgtaggat 449521 ccatatattg cgagatgaaa tataaaccaa acgtactgga cgaagtgatc aatgatacat 449581 atggtgcacc agatttaact aaaagttata ctgataaaga gggtggttct gatgaaatta 449641 tgctcgaaga tgaaagtggg agagtgcttc tagtgggaga ttttattcgg tctacaccct 449701 tcatcacggg tgttgttgta ggtatactgg gtatggaagc tgaagccggg acatttcaag 449761 ttttagacat atgctacccc actcctttac cacaaaatcc tttccctgca ccaattgcta 449821 cctgccccac caggggaaaa attgctcttg tttctgggtt aaacctcaat aatacatcac 449881 ctgataggct attgagattg gagattttga gagaattttt gatggggaga atcaataaca 449941 aaattgacga catttctcta attggtagat tactgatatg cggcaactct gttgacttcg 450001 acattaaaag cgtgaacaaa gacgaattga tgatttctct aactgagttc agtaaatttc 450061 tacacaacat tttgccatct atatctgttg atattatgcc cggaaccaat gatccaagtg 450121 acaaatctct accgcaacag cctttccaca aatcattgtt tgataagtcc ctagaatcat 450181 acttcaacgg ttctaacaaa gaaattttga atttagtgac caacccatat gagtttagct 450241 ataatggcgt agacgttcta gccgtttcag gcaaaaatat caatgatatt tgtaaatacg 450301 taataccatc aaatgataac ggagaaagtg aaaacaaggt cgaggagggc gagagtaatg 450361 atttcaaaga cgatatagag catcgcctgg accttatgga atgtacaatg aaatggcaaa 450421 acatcgcgcc caccgcacct gataccttat ggtgttatcc gtacactgat aaggatccat 450481 ttgtattgga taagtggccc cacgtttaca ttgtggcaaa ccagccatat tttggaacaa 450541 gagtagtgga aataggtggt aagaacataa agataatatc tgtccctgaa ttcagttcta 450601 ctgggatgat aatattactg gatttggaaa cgttagaagc agagacggtc aagattgaca 450661 tttaaataaa acaaggaata atttccacat agatatgcaa ttaagtttta tatgtaaaag 450721 tgagcattca tcgttcagct caaaatacgt ttcttgtcac agctggtaga aaaactatga 450781 gcgttttttc ttacccgcag tcggagaaaa attttttctt cgaagaggcg aaaaagagaa 450841 gaagagaaag cacaaatctg atgaaatagt agtataaaat cgcatttaca aattttcaac 450901 cattgtttat ttcctaggtc attaaagagt aaagtgcaat ctgtttacta atcagttttt 450961 gtcttcatat ttttgtgtct tttctgctgc ctcacgcacc ttctataata caccaaataa 451021 tgtccacttc tcattgcaga ttttatgaaa acaaataccc agaaattgac gatatcgtca 451081 tggttaacgt ccagcagatt gctgaaatgg gtgcttatgt taaattgtta gaatatgaca 451141 acattgaagg tatgattcta ctaagtgaat tgtcccgtag acgtattagg tcaatccaaa 451201 aattaattcg tgttggtaaa aatgatgtcg ccgttgttct tcgtgtcgac aaagaaaaag 451261 gttatattga tttgtccaaa cgtcgtgttt cttctgaaga tatcattaaa tgtgaagaaa 451321 aataccaaaa atctaagact gttcattcca ttttaagata ctgtgccgaa aaattccaaa 451381 tccctttgga agaactatat aagaccattg cttggccatt aagtcgaaaa tttggtcacg 451441 cttacgaagc tttcaaacta tccatcattg acgaaactgt ttgggaaggt attgaaccgc 451501 catcaaaaga tgttttagat gaattaaaga actatatctc caagagatta acaccacaag 451561 ctgtaaagat tagagccgat gttgaagtgt cttgttttag ttacgaaggt atcgatgcca 451621 ttaaagacgc attaaaatca gctgaagaca tgtccacaga acaaatgcaa gttaaagtta 451681 aattagtcgc cgccccatta tatgttttga ccacccaagc cttggataag caaaaaggta 451741 ttgaacaact ggaaagcgct attgaaaaaa ttacagaggt tattacaaaa tacggcggtg 451801 tttgcaacat taccatgcca ccaaaggctg tcactgctac tgaagacgct gagttacaag 451861 ctctattaga aagcaaagaa ttagataata gatctgactc tgaagacgat gaggatgagt 451921 cagacgacga gtaatcattg ccgcgcctaa tttttctagg tgttttcaag tgtcatactg 451981 ttttagaaaa ttttgtatag aacaaatacg tatatcctgc catatcatat tctttgcaat 452041 atacaccttg tacatttggc tattataaat attacaatcc atttaatcat aatcaaaatt 452101 taatttctgt taccacgggg ttgtcagtgg agcatgccct gccggttctc tataatttat 452161 ctttttcaca tgagatattt ttacctcaaa aggtagtgat gctgtaataa tatgaggctc 452221 ccccctttcc ttcggaattg catttaaatc attggggaac actaagacaa gacaaagggg 452281 ccgtccactc atgtgatttt caacaaaaca gataacatgc ggatacacac tgatatattt 452341 tcaaaggaaa gtctgactga tacttaagtg aagtggtcct agtcggtggc ttaggtggac 452401 tacagtgcaa agaatagaat ttttcaaaca tgtcaatacg tccagcaaca catgcaggct 452461 catggtattc caatagagcc caagaattat ctcaacaact gcatacatac ttgatcaaaa 452521 gtacccttaa aggcccaatt cacaacgcca gaattatcat atgtcctcat gccggttaca 452581 ggtattgtgg acccactatg gcctactcgt acgcatcgtt ggatttgaac cgtaatgtta 452641 agagaatatt tatcttgggg ccgtcgcatc acatctattt caaaaaccaa atattagtta 452701 gtgcattcag tgagctagag acgcccttgg gtaatctgaa agtggataca gacttgtgta 452761 aaacattaat acagaaggag tatcctgaga acggaaagaa gctgtttaag ccaatggatc 452821 atgacactga tatggctgaa cattccttag agatgcagct ccccatgttg gtggaaactt 452881 tgaaatggag agaaatttct ttagatacgg tgaaggtatt tcctatgatg gtttctcata 452941 acagcgttga tgttgatcgt tgcattggta atatcttgtc ggagtacatt aaggatccga 453001 acaatttatt cattgtaagc agtgatttct gtcattgggg ccgcagattc caatatactg 453061 ggtacgtcgg aagcaaggaa gagttgaatg atgccattca agaggaaaca gaagtggaaa 453121 tgttaactgc taggagtaaa ctttcacatc atcaagttcc catttggcaa tccattgaaa 453181 taatggacag atatgcgatg aaaacgctaa gtgatactcc aaatggtgaa aggtacgatg 453241 cttggaaaca atacttggaa atcaccggaa acaccatatg cggcgaaaag ccaattagtg 453301 tgatactaag tgctttatcg aaaatccgtg atgccggtcc ttcaggcatc aaatttcagt 453361 ggcctaatta ttcacagagt tctcatgtga caagtattga tgatagtagt gtcagttatg 453421 cttcaggtta tgttactata ggataatgat cacggctaaa acggtcgaat gtaagcatat 453481 atctttcgat tgtataattg ttcccaaata ctacagcatc tcaaggaaaa aaaaacaaaa 453541 acttccaaaa aaatcgaatc cctgaggaat ctttaataca ttttcaatct atttaagttt 453601 tataaacgtg tatatgagat gtcatgagca tgaattatta ataataaaaa ctaaatcatt 453661 aaagtaactt aaggagttaa atttaagcct tggcaacgtg ttcaaccaag tcgacaactc 453721 tggtagagta accgtattcg ttgtcgtacc aggaaaccaa cttgacgaac tttggagaca 453781 attggatacc agcggcagca tcgaagatgg aagagttaga gtcacccaag aagtcagagg 453841 agacaacagc gtcttcagtg taacccaaga cacccttcaa cttaccttca gcggcagcct 453901 tgacaacctt cttgatttca tcgtaggtgg tttccttgtt caacttgaca gtcaagtcaa 453961 caacggaaac atcgacggtt gggactctga aagccatacc ggtcaactta ccttgcaatt 454021 ctggcaagac cttaccgaca gccttagcag caccggtaga ggatgggatg atgttaccgg 454081 aagcggttct accacctctc cagtccttgt gggatggacc gtcaacagtc ttttgggtgg 454141 cggtcatgga gtgaacagtg gtcatcaaac cttcttcaat accgaaagca tcgttgataa 454201 ccttggccaa tggagccaaa cagttggtgg tacaagaagc gttggaaaca atcttcaagt 454261 cagaagtgta tttttcttcg ttaacaccca tgacgaacat tggggcggtg gaagatggag 454321 cagtgatgac aaccttcttg gcaccagcgt caatgtgctt ttgagcagtg tccaattcct 454381 tgaaaacacc agtggagtca atggcgatgt caatgtttag agaagcccat ggcaagttag 454441 ctgggtctct ttcttggaaa gtggcgatct tgtgaccatc aacgatgatg tgcttgtcat 454501 cgtgggaaac ttcaccagcg tatctaccgt gagtagagtc gtacttgaac atgtaagcgg 454561 agtagtcgtt agagatgaaa ggatcgttca aagcaacaac ttcgacgttc tttctttgca 454621 aagcaattct cataaccaat ctaccgattc taccgaaacc gttaatagca actctaacca 454681 ttttgttttg tttgtttgtg tgatgaattt aatttgaaac taagttcttg gtttttttaa 454741 catttaaaca aacaataata aaatgaatag acacacaaga aaaaaactat cttgaatgag 454801 tgcaaccttt atatattctt ccaaacctac aaaaaaattg caggtctgcg atcactgggt 454861 actatcaaaa cacatattag catacgtatg tgttcgtacg tgcggtccgc aaggtctttg 454921 tgacagccat gacatgattg gattgaatag ttcacttcag ctgtcaccac cagttttagg 454981 ccctaacaca tcagtcgagt tccactaggc tttgttagcc gtagctgcgt tgcaacaact 455041 gcgcaaaacg cgcgacttcc tgtaaatgcc gcagatcacg tggtaaagaa aagaaacaac 455101 aggccgaccc agtttcgttg tttcttttca ttatttctgg atgctcttca caacgtattt 455161 catgacatac ttattgaatt agtggaagcc caaaacatca ttaccctgga aaacttaatt 455221 gacgtaaatt aacttcagtt gtcttatgtt ttttgcatcc ttaactttag ccgcgcaggg 455281 ataatcatat atgtcgaaag agcaactaaa caatacttaa aaacgtgttt gaacttttac 455341 gaaagggtaa cgacaaataa tcattcactg gaaaaaccaa taaaccataa gtaaatgaaa 455401 aactgtttca accgatgttg gtactttcca tgtcttaaaa gagtacaatt tataaattaa 455461 tgaaaacaca gaagtattta gatcggctca aatgtttttg gacattaaaa gatcttgaaa 455521 ctgagtaaga tgctcagaat acccgtcaag ataagagtat aatgtagagt aatataccaa 455581 gtattcagca tattctcctc ttcttttgta taaatcacgg aagggatgat ttataagaaa 455641 aatgaatact attacacttc atttaccacc ctctgatcta gattttccaa cgatatgtac 455701 gtagtggtat aaggtgaggg ggtccacaga tataacatcg tttaatttag tactaacaga 455761 gacttttgtc acaactacat ataagtgtac aaatatagta cagatatgac acacttgtag 455821 cgccaacgcg catcctacgg attgctgaca gaaaaaaagg tcacgtgacc agaaaagtca 455881 cgtgtaattt tgtaactcac cgcattctag cggtccctgt cgtgcacact gcactcaaca 455941 ccataaacct tagcaacctc caaaggaaat caccgtataa caaagccaca gttttacaac 456001 ttagtctctt atgaagttac ttaccaatga gaaatagagg ctctttctcg agaaatatga 456061 atatggatat atatatatat atatatatat atatatatat atatgtaaac ttggttcttt 456121 tttagcttgt gatctctagc ttgggtctct ctctgtcgta acagttgtga tatcgtttct 456181 taacaattga aaaggaacta agaaagtata ataataacaa gaataaagta taattaacat 456241 gcctgctcct cacggtggta ttctacaaga cttgattgct agagatgcgt taaagaagaa 456301 tgaattgtta tctgaagcgc aatcttcgga cattttagta tggaacttga ctcctagaca 456361 actatgtgat attgaattga ttctaaatgg tgggttttct cctctgactg ggtttttgaa 456421 cgaaaacgat tactcctctg ttgttacaga ttcgagatta gcagacggca cattgtggac 456481 catccctatt acattagatg ttgatgaagc atttgctaac caaattaaac cagacacaag 456541 aattgccctt ttccaagatg atgaaattcc tattgctata cttactgtcc aggatgttta 456601 caagccaaac aaaactatcg aagccgaaaa agtcttcaga ggtgacccag aacatccagc 456661 cattagctat ttatttaacg ttgccggtga ttattacgtc ggcggttctt tagaagcgat 456721 tcaattacct caacattatg actatccagg tttgcgtaag acacctgccc aactaagact 456781 tgaattccaa tcaagacaat gggaccgtgt cgtagctttc caaactcgta atccaatgca 456841 tagagcccac agggagttga ctgtgagagc cgccagagaa gctaatgcta aggtgctgat 456901 ccatccagtt gttggactaa ccaaaccagg tgatatagac catcacactc gtgttcgtgt 456961 ctaccaggaa attattaagc gttatcctaa tggtattgct ttcttatccc tgttgccatt 457021 agcaatgaga atgagtggtg atagagaagc cgtatggcat gctattatta gaaagaatta 457081 tggtgcctcc cacttcattg ttggtagaga ccatgcgggc ccaggtaaga actccaaggg 457141 tgttgatttc tacggtccat acgatgctca agaattggtc gaatcctaca agcatgaact 457201 ggacattgaa gttgttccat tcagaatggt cacttatttg ccagacgaag accgttatgc 457261 tccaattgat caaattgaca ccacaaagac gagaaccttg aacatttcag gtacagagtt 457321 gagacgccgt ttaagagttg gtggtgagat tcctgaatgg ttctcatatc ctgaagtggt 457381 taaaatccta agagaatcca acccaccaag accaaaacaa ggtttttcaa ttgttttagg 457441 taattcatta accgtttctc gtgagcaatt atccattgct ttgttgtcaa cattcttgca 457501 attcggtggt ggcaggtatt acaagatctt tgaacacaat aataagacag agttactatc 457561 tttgattcaa gatttcattg gttctggtag tggactaatt attccaaatc aatgggaaga 457621 tgacaaggac tctgttgttg gcaagcaaaa cgtttactta ttagatacct caagctcagc 457681 cgatattcag ctagagtcag cggatgaacc tatttcacat attgtacaaa aagttgtcct 457741 attcttggaa gacaatggct tttttgtatt ttaatcgtca taaaatgctc ccatctcaaa 457801 agtagggcaa aattcatgat cgaccgcgca aaataaatag atttgcaaat aagttttgta 457861 tgtacattta ttaatatata taatatatca aaagaaaaaa atcaaaaaaa aaaaaaaaaa 457921 aaaattgcac tcttattcag tcatcaatta caaaacctag agatagcgat ggtgcatatt 457981 caataaaaaa ctccttatac tgtcgagaaa gcttattatt ggtacttctc gaagatacta 458041 aaaaaggtta atttttggag acggaggcaa tagcgactag tcatactggt cgacattaat 458101 ttcaattttt ggctgtgccc acctcaattt ttgtttatta taccatgggt aagctggcaa 458161 aacacatatt aaagtaatca cacaactaat gccatacgca gtcagtaaaa ctttcaggga 458221 ctgttgtgca aatcccaata tacacgctac caaagctccg atcatgagcg atagctgttg 458281 aaatttttct gttttccgtt ggctgggaaa atctattgga aaaaccagtt tcctttgtac 458341 atcttgtaat atctcagaca ttgaagttga ctatgacgtg acgttgatct tgtttgagta 458401 ttgcttgacc aatcctggag taacttcgtt taatctgcct cgtttttttc tctaaatagt 458461 ttctattatc cctcctccac gcgagatgta tttaaaatgt gaaaagtgta cacatggcgt 458521 tcatcttacg tagatgagag aaacgctaag aagccaacca aactagtata atctatacat 458581 ttatagatgt ttgtgtagaa ccttattttt atactcttgt attatattac attacttgca 458641 ttaaaccgtc atttcaccaa taatttggtc ctttagccaa ttaacatatc tgatgaatgg 458701 ttcacccttg ctaacatcaa taacactatc gttcgtagct tttctatata tattaatcag 458761 gcccttatcc ttagagagct cgttaaatag tttacaattc aaaagatcta actgaaactt 458821 ccaaatgggt aacaattcat tctgtaacac attaactaag atcttcatct gtaaatcgtt 458881 catctgtgac tgttgtttac tcatagggat cttgttcaaa aatttgtaga gattaacgaa 458941 tcctgataaa caattttgca tttgtaatat aaattcatct ttaaaatcga catttaatct 459001 gtttaattcc tggaaaatat acctgttcac tccataaatg gaggtgacta gaaccttctc 459061 gatcaaatgc cggcattttc caggagtttc aaagtgatct aactcacaac tatccaataa 459121 taagcggaat cctgtcctta aatcgtaaat tagttcacaa atatcactct ttagtgcaag 459181 gagttctttt ttgtgtgaaa taaatgtgcc agaatggttt aatacttcgt cttcctgctt 459241 ttgagccaga taatacaaga catacattag atccgtcata taatgtgaag tattcagaat 459301 aaacggcact atttgattca gcagtataac atttttcttg ttgttttcgg atattccgtc 459361 attgagcaaa agtttggttt gtaaagacga aactgtactt tcattagatt ctcgtgtttc 459421 actcatacgc ctttatatgc tatcacagtt accttatttg tcctttttct tgtagagcta 459481 ttctctattc tgctttgact taactagcgt gaaattaaaa ccaacgccgc ttatctaatc 459541 acaataaaag atcagactgt gaaattaata aaaaggaaag gataaaacga cagatatcgc 459601 actaactttg ttagaaacat tatgcagaca aaagaaggag atgcatgtgc ctttgtattc 459661 ttttaaacgc aaaaagggca ggtctatgat taagtatgaa tgagcgatat aaaatttaag 459721 tagaaaaggg aagataatag tactatatat aaatatataa atgcattttt ttacatacct 459781 gttgggtgaa taatttacct agctgttgga tttgctgtta ctgtattatt gtcgtcatca 459841 ttgccatcgc ctttattgtt atcattgtta ttgtcatcat tatcgttgtc actgtcatta 459901 atctgtaact tagactgtat atcgtaacat tcagacagcc ttgttaatga ggtcatgcct 459961 tctaggcttt cttgatcaat gtccagagat atattgggtt tgtctaatga tccttgatga 460021 gattgatgct gcagctgacc ttcccaaggc ctaggtcttg gcctcaatga aggagtacta 460081 gctaaaccct catccagcgt aacattgggc acctccacaa tattaggtat aggcttgtta 460141 ttcagaatgt gatccagcaa ctcttcataa ctaagttcac cacctgctgc catgcttgac 460201 tcgttatgtt cgcaatcaat tttcaagagg taaaccgaaa catgtggagc tcttttacag 460261 gctccgataa taataaaaga aactttaata gttggtaaga acttgacaaa aaaaaacaca 460321 atatatatac ataaaaaagt caacaactga caagcaaggt aaaaggtgat aaagttgaaa 460381 gatgactggc gaagaatggg gcttgactgt actgtcattc ttggtaagag tcggattttt 460441 tctttttggc atttaccagg acgctaattt caaagtgagg tacactgata tcgactattt 460501 tgtgtttcat gatgctgcta aatatgtata cgaaggcaaa tcaccttatg caagggatac 460561 atatcgttac acaccgctac taagttggct gctagtgcct aatcattatt ttggatggtt 460621 tcatttgggg aaggtcatat ttgttatttt cgatttggtt actgggctca ttataatgaa 460681 gcttttgaac caggccatct ccagaaaaag agctttaata ttggaaagca tttggctatt 460741 gaatccgatg gttatcacca tcagtacaag gggaaacgct gaaagcgtgc tttgctgttt 460801 gatcatgttc acgctttttt ttctacaaaa gagtagatac accctagctg gaatcttata 460861 tggtctttct atccatttca aaatatatcc aatcatatat tgtatcccaa tagcaatttt 460921 tatatactac aataaaagaa accagggtcc acgaacacaa cttacatcgc tactcaatat 460981 cggtttgagt actctaacaa ctttgcttgg atgtggttgg gcaatgtaca agatatacgg 461041 atacgagttt ctggatcagg catacttgta ccacttatac agaacggatc acagacacaa 461101 tttttcagtg tggaacatgc tattgtattt agattctgca aataaggaaa atggtgagtc 461161 caatctctca aggtacgcat ttgtgcctca attgctgctt gttttagtaa ctggatgtct 461221 tgaatggtgg aatcccacat tcgataacct attgagggtt ttatttgtgc agacgttcgc 461281 atttgtgaca tataataaag tgtgcacatc gcaatatttt gtttggtacc tgatctttct 461341 accattttac ctctcaagaa cgcacattgg ttggaagaag gggcttttaa tggccacgct 461401 ttgggtagga acgcagggaa tttggttaag ccaaggttac tatttggaat tcgaaggcaa 461461 gaatgtattc tatcctggac tatttattgc aagcgtgtta tttttcgtca ccaatgtgtg 461521 gctactgggt caatttatta ctgatattaa gataccgacg caacccacag tttccaacaa 461581 aaagaacaac tgactgacgt gaacttgcac catgtacatc aattctataa atctactcat 461641 ataatgaatg tgtaaatatg aaaaaaaaaa tgcaaaagcg caccaccaaa agagaaaaaa 461701 gctgaaaaaa aaaaggaaaa agatacttga tgtgatgtgt gagtgaaaaa attattaatt 461761 cctactggat aaaatcaccc caaggaaaca gttcaagagc taaactaaag aaaagcatat 461821 tgcataaaat gttaagagaa gtcatctatt gtggaatttg ctcctaccca ccagagtact 461881 gcgagttttc aggaaaatta aagcgttgta aagtttggtt atctgaaaac cacgcagacc 461941 tttatgcaaa gctatacggt actgacgata atacgcaaga ggtggaagcc gtgaccaaca 462001 aactggctga atccagtatt ggcgaagcta gagaggaaaa gttggaaaag gacttgctga 462061 aaattcaaaa aaaacaggaa aacagggaac aaagagaatt agctaagaag ctgtcatcga 462121 aagtgatcat taaaagagaa gctaggacca agagaaagtt tatcgtcgct atctctgggc 462181 tggaagtttt cgacatcgac atgaaaaagc tagccaagac atttgcgtct aggttcgcca 462241 cagggtgctc agtctcgaaa aatgcagaga aaaaagaaga agttgtcatt caaggtgacg 462301 tgatggatga agtggaaact tacatacatt ccttgctgga agaaaaaggc ctaaaggacg 462361 tcaaagtgga aaccatcgat gctaagaaga agaaaaagcc tgctgcagaa ggagctgcca 462421 agtaagcaat ccataaatat gtaatagcac cgttctggga gaaaaggact ttttacttgg 462481 taaccaggcg tgtaggttag atagtcaaac cctatatcgt tcttgagatc gtcgctcata 462541 tatactgtgc agccggccct cgtgcgcctg cgccgttcct tctctgaaac cttcgtagta 462601 ggacaataaa tatagtcccc attgcctatt caaattattt gcaaccgaaa aactgcaaaa 462661 tttgttgttg accataggcg tacaaaacac aactcaatcc agccgtaagt aagtatagtt 462721 atgacttcat ctctagatga tatagaacca acagcatata ataatatgga agcggacgag 462781 gaatattgca gacgcaacga tatacatgac ctttccagcg tggtcggtga tgctgtctca 462841 caaggtgtgc cagacatgga tggtcaaaca acggattctt cgaaggaccc tgagccaaat 462901 tccgaggata agaaagcgtt tcctccttcg agtggctcat ttttttctcc taatctacag 462961 ggtcaaagga agaaagttct tttaaagttt gttttcacaa attgcttact ggccataatt 463021 tgctttacaa tgtttgtgtt gttctggggg gctctttacg acaccagcaa gtatctacac 463081 aaagttaagc ttctggttgt tatccaggaa ccccctgtgg taattttgga taataacagt 463141 tccatggtag tgccctccat atcgtatgct ttgcctactt ttatcaataa aataccatgt 463201 gattgggata tttataacag tcctaccttc caggccaagt tcgacgtaaa tacgccacag 463261 caagtcaatg acaaggttgt cgatttggtt tacgacgaaa aatactggtt tgccattaat 463321 atcaagccaa acgccacgga gactctattt gaatcactaa tcaacgatac cgcaccacta 463381 ttcaattcta cgctgtttaa tcaggtggta tatgaaactg gtagagaccc gacaaaccta 463441 aaatcaacga ttttaccggt tgctcagacc attgaagagt actaccatac attctacaca 463501 ctaaattatc tgccgccgtt attgacaaac ataacccagg tatatcgtta tgcactaact 463561 aacaatgcaa ggtatatcgc tgcagcaggt aaatataact acgaatacta tgaccacaga 463621 ccattcacag accgtattct actggcaccc acacaaatcg gtgttgttta ctgtttactg 463681 ctaacttttt tccaatttct attgtacggc ccattacacg tagaaatggc aaaagtgcta 463741 agaccagcca acggtttaat ttaccgtatc gctatgtcat ggttcacctt tttctttgcg 463801 tctttgttct tctgcacaac aaccgccatc tttcaagtcg attttaccaa gtcctttggt 463861 agaggtggct tcgtcgtata ttggatgtct acgtggctct tcatgcttgc tgcgggagga 463921 gctaacgaaa atgcggttat gcttgttatt acgttaggac cccagtatct cgggttctgg 463981 atcctatcat ttgtcattct caatattgca ccttctttct tcccattagc gctaaacaat 464041 aatgtttata gatatgggta catgatgccc gttcacaacg tcatcgatat ctacagggtt 464101 attttttttg acgtgacaag acgcaagatg ggtcggaatt atggtatttt agtcgcactc 464161 attgccttga atacggcact gttaccattt gttggcaagt atgctagtag aaaactaaaa 464221 cagaaggctt tagtggcagc aaagcagagt taatttcgta gattataatt aaggcgactt 464281 ttcaaataaa aaaatactga tcgttgtttt tttttaaata aatgtttatc cattcaatgg 464341 actataataa atatttatat atatatatat atgaaaagat tgcgaacaaa aaagatgatg 464401 gaaaaggaga atctctatat atatattcat cgattggggc ctataatgca tcaagcatct 464461 aaaacacaac cgttggaagc gttggaaacc aacttagcat acttggatag agtacctctt 464521 gtgtaacgag gtggaggtgc aacccaactt tgtttacgtt gagccatttc cttatcagag 464581 actaataggt caatcttgtt attatcagca tcaatgataa tctcatcgcc gtctctgacc 464641 aacccgatag gaccaccttc agcggcttcg ggaacaatgt ggccgattaa gaacccgtga 464701 gaaccaccag agaatctacc atcagtcaac aatgcaacat ctttacccaa accgtaaccc 464761 atcagagcag aggaaggctt tagcatttca ggcatacctg gtgcacctct tggaccttca 464821 tatctgataa caacaacggt tttttcaccc ttcttgattt cacctctttc caaggcttca 464881 ataaaggcac cttcctcttc gaacacacgt gctctaccct tgaagtaagt accttcctta 464941 ccggtaattt tacccacagc tccacctggt gccaatgaac cgtacagaat ttgcaagtga 465001 ccgttggcct tgattgggtg ggagagtggc ttaataatct cttgtccttc aggtaggctt 465061 ggtgctttct ttgcacgttc tgccaaagtg tcaccggtaa cagtcattgt gttaccgtgc 465121 aacatgttgt tttcatatag atacttaatc acagattggg taccaccaac gttaatcaaa 465181 tcggccatga cgtatttacc agaaggtttg aagtcaccga tcaatggtgt agtatcactg 465241 attctttgga aatcatctgg tgacaacttg acacccgcag agtgagcaac agccaccaaa 465301 tgcaaaacag cattagtgga cccaccggtt gcaacgacat aagtaatggc gttttcaaaa 465361 gcctcttttg tgaggatatc acgaggtaaa atacccaatt ccattgtctt cttgatgtat 465421 tcaccaatgt tgtcacactc agctaacttc tccttggaaa cggctgggaa ggaagaggag 465481 tttggaatgg tcaaacctag cacttcagcg gcagaagcca ttgtgttggc agtatacata 465541 ccaccacaag aaccaggacc tgggcatgca tgttccacaa catcttctct ttcttcttca 465601 gtgaattgct tggaaatata ttcaccgtag gattggaacg cagagacgat atcgatgttt 465661 ttagagatct tcgaagaacc acatgttgga tgaccgggca agatagtacc accatatacc 465721 atgatggaag gtctgttatg tctacccatg gccatcatga caccgggcat gtttttgtca 465781 catgatggga tggcgatgtt agcatcgtag tgttgtgcca tcatgatggt ttcaaaggag 465841 tctgcaatga tttctctact ttgtaacgag tatctcatac ctttagtacc catagagata 465901 ccgtctgaaa caccgatggt gttgaactgc atagctttca aacccgcttt ttcaatggat 465961 tgagaacatc tgttattcaa gtccaataga tgcatgttac atgggttacc ggaccaccaa 466021 caggaaccaa ccccgacttg aggcttcttg aaatcttcct tcttgaaacc ggtggcataa 466081 agcatggcct gggacgcacc ttggccctta ggttcagtga tgatatacga gtacttgttg 466141 agcttctttg caacgcatct cgttgtagag aattgtctag atgtagcaac tttcgttaac 466201 aagcccatct ctactttttt cttggctgtt tacaaaaaaa tacaagaatc cgttactaaa 466261 gattacaggc gctacaatgc ataataaaac ttcagtctct tcttttgtta cattatataa 466321 tatactacta tattactgag tcatctggag aggaaaagag aaaatttttt ttcaggcccg 466381 gttccgctcg cagcgaagaa cagcgccatt taactatgtg actagttaat tttttttctt 466441 ttcatgggtt cagcgaggac ggaatggata caagagggaa taagaacata aaaaggtgag 466501 gtggagaagc aaatgccaac ctaacctacc cgcttgatca catgaacacc gcttcctgat 466561 tcaacgatat cgcttacctc gccgaccttg agctggaagg cagcgtcttc aaagctaggc 466621 tgcatctcgc ctctcccgaa ccagccgagg tcgccgcctc gcttgtatga agagcaatct 466681 gatctctctt tagccagggc ctcgaaggag ttcgtcttag agtcgtcatc caacctcgtg 466741 attaaggttt tcagttcgtc cgtagcgtct tgcttggata tcgtaatgtt ctcggatcta 466801 tgcgatgcgg gtcttcttga atccttgtgc ttgatgagaa tgtgcaggca tcttacacgc 466861 actggatggt ctcttaagtg cttgtgtagc tggtccttgt tggtgccctc aggctcctcc 466921 cattgcgagt gcttcgtctc tggattgaaa aaatactctc ttttcttgga cttactatac 466981 ctgacggtcc acggggttgg cagcccggtc ctcgatgcta cgtcagatgg cattggtgcg 467041 tcgttgtggt gccgtagtcg gttatgcgtg ggaataagta ccacaatgat cattcaggtc 467101 ctttttctac ttagatcgaa gggaaaaagg tatgataccc gctcgtgaaa ggtgatgtaa 467161 taataaatag gatattatta tataatataa gaatatatat gtatgtgttt atacgtggga 467221 gggaattgtc ctcagaactt ggctcgaatg tctcgttctg acccgtagac aacgtagccc 467281 tcctgagaga cgcttgccat gatgcgtccc gactgtgtgt cgaaatactt gccctgtacg 467341 aggtgcttgt cccagtggga cctgggattc gaaatcttaa gatagatcca attgttcaca 467401 tgaggcaact ggtgaaagta aatcgtgtgg tcgagcgaga cactgaaact gtggcagtac 467461 aaaggcaggt tgtggaagta cgggatcgtg agtaggaggt aggaatcgga cagatacgca 467521 aaggccacgt agttgtagcg agcgtcgttc tcaggagtaa tgctcttcgg gatcctgtac 467581 ggatgatgct tgtgtaaaga agactcgtcg cccgcgtgct ccacggtagt gatgggaggt 467641 ctcactttga cgaaataatc cagctcgtcg gtgtgtcttg ccgagtagaa catgtccttg 467701 gggaattggt actccatgac tccgtattga aacgcatcca catacttgct catcgaggtt 467761 gcgtcttgga acctgtcgga caatgaggca tacctgctca atttctgtgg gtccagaact 467821 tctttctgga aaagcgaagt ggcctcttca taacgatgag ggtctggctg cttaccttgc 467881 aggcctggaa tcgtctccca gtgctgcaag gagtcgtgct ccttggaccg ttgcacggca 467941 aataagatca tcgacgtaaa tatcaacttg tcgtgctgat aagcactaac ctgcttatgg 468001 atgaaatttc taccgtttct cagattctgc acatggtacg tgatcttggt ccgcggatca 468061 ccacccttga tgaaatacga atgtagcgat gtggggaaga agttcaatgg cacagtatgc 468121 aatgacgcca gcagcgattg tgataccagc gttccaccaa aagtgccctt agaccctacg 468181 ggcgcggcag gcagatactt tgtgacaaaa ctggtaggcg aaagaggaac cagttccaat 468241 attttctcta ggttggacat ggccattttg gaagcactca tttttatgca atcttgtctt 468301 atcttgtctt gctcatggtg gatactgaat tgaaaccctt ttctggttta tatccaactg 468361 gcgtggtttt tcattgtagg atgaggctcg gtgtttatgc cgtctcttcc gaggatgcaa 468421 tcaaaggctc tctcctttgt tggggtagta gcaagtccaa taagcaacgc ttgtttgttg 468481 attgggccga tttacatagc ctatacactg ctgttacata tgcctgtgta gaatgaaaaa 468541 gcaggacgcc cgtttcacag ctcagattcc agagtgtcgg gtcttagttc ctcccaggga 468601 ataatggtcc tggccgcacg cttcagccga tggctagcgt catcattgtc ttcgctattg 468661 tggttttggc tggtggatag ggttggggag ctggatcttc tgcgtttcat ggaccttgtg 468721 accatcattc ttggtggcgg cacggacttc ttacgctgct tatcgtgggc ttcgtccata 468781 tcgtgcagga gtgtggtgcc attcagagac acatccgggc gatcgtaggc gtgatctgcc 468841 ttttctcgaa acgccatctc tagagcagtc tggcgggttt gtagactgtg catgtctttg 468901 gatagagaca ggagcacttt atgcacgtcc tccagttggc tgccgacgtt gaagagcatc 468961 tcctgggtgc acctcatcga cttttccgtc tcatgctgct tgttagttac gtgtcgcgtt 469021 atcttggaat tatacctgct tatttcttcg actaatacct gcctgtagct ggaatccgac 469081 tttgtcttct tctcgtcgcc tttcgataac attgctgttg acactttgtc cagttggttt 469141 tcaatctggg aagccaaatc ctttattaag gttttcacgt ttcctatact acagttgtta 469201 gtaaatgtgt tttggaagaa aatgaataaa aaacttgagg gtatgcactg tgttggtacg 469261 aaccgttcgt agcagcatct tgttccagta gctggttaaa cttgtttagc gatttacata 469321 atgtcttaga attttcattt aaaactttaa ttagcttgtc agagttttcc ctcagctcca 469381 tactctccaa ttccagttta cctgcccatt ccagtatctg cttgtccgat tcctctaaag 469441 cgcctgcatt cgctactttc ccactgtggg agaatataga tctgaacggt gatgatgttt 469501 ctgtaatcat caacgagtgt tcagaattag cctctgaaac atctgtagat atctcgtctg 469561 ttctacctct agcgaccatt ttactaaatg tttctacacg tctgcagtat ccttgttttg 469621 cttgttttcc ttctttctgt tcttgttgat tttcccttta agtcctgaaa atactatcat 469681 ggcgtaaagg gaaaaaaaaa aactaatctt acgtggttct tataagatgg accagcaagc 469741 tgcatacagt acaccataca agaagaacac actatcgtgc accatgtcag ccaccttgaa 469801 agactactta aataaaagag ttgttataat caaagttgac ggcgaatgcc tcatagcaag 469861 cctaaacggc ttcgacaaaa atactaatct attcataacc aatgttttca accgcataag 469921 caaggaattc atctgcaagg cacagttact tcgaggcagc gagattgctc ttgttggcct 469981 catagatgca gaaaatgatg acagtctagc tcctatagac gaaaagaagg tcccaatgct 470041 aaaggacacc aagaataaaa tcgaaaatga gcatgtaata tgggaaaaag tgtacgaatc 470101 aaagacaaaa taatatagtt gcaataatag taataataat aataataata ataataataa 470161 taataataat aataataata ccatgtatag aagtatataa atcatacaat aaatttaagc 470221 attaacccgt cacggactgg ccatcttcag atgcttcttc tcttcgccaa tgccacagtc 470281 gggaggaatc cccatttggt acatctttat ggccagctcc atcaaataat cgatggcttc 470341 gttgaaaatt ttggccttat cgattgtcgg accccaaaca aaaatgccat gtctcctcac 470401 aattacggcg catgtgtctg gataatcttt aaaagtcttg tgcaagtcat cgatcaactc 470461 gtcctcatgc gccatgtttt caatgatggg aatcttcagc gtatcaaaaa acgatagcgc 470521 catgggtttc ttggtcacag ggtccacctt tccgcttgga attgctttga tttgttcgat 470581 gttagcaatc ctgaactcat cgccaaatag caaggagcat atcacagcat tttgggagtg 470641 tgtatgtatt atagcacctg catttttctt ttggtagcac gctaagaaca atggagtaca 470701 tgcgcttggc ttgtaaagct tgggagagcg caaatactct aatgtctgag cgtccatgac 470761 aaacaaatcc tcaggtatca tcttctcctt ctgcacccca gatggggcga gataataata 470821 attcgtgtta ggatctttta ttgaaatccc acctccagtt ccggtgcacc aattattatg 470881 aaaaaactgc ttgcatagcg tgcaaatgag atttgctgga tggcacggat catctgaatg 470941 tatcagaaca tcttgtgaag acatagtcgt tcactggctc cccttgttag ttcagtgctt 471001 aaaaacgtta catatcttga tgaacagcta gctgctttga tcaagagaaa aaaaaaaaaa 471061 attggcaccg catcttagtg ccgcaatctt acgtaacaag agagctataa aagtacaact 471121 aacaactctt ctaatactta attagattga gggcgtgcgt agtttaacgt cttgcaatgg 471181 aaacatgtcc tcttttcgac atcattttca aaatctaaaa tggcttcttt cacttgggta 471241 cctaagtcta acatttgcag ttcactctcg tggaccactt ggcgacaatg agaacagtac 471301 caccttatct tatcgttttc tcccccaggc ctatcttgtt ccacaacaat acccacagta 471361 tcagcaaacc gaacaggact gtgaggaaca tttcctggca ataaatatga atcgccttca 471421 ttgatgatga tatcaatgaa ctttggttca gcgtctgtct catccacaac ctttaaaagc 471481 atagatcctt ttttttgata gaaccattcg ggagttggat tgatgtgata accggttctt 471541 tcattaggcc caccgacaat catcacagtg aatccccctt tatgtaagca ataattattc 471601 accggtggtt tcaaaaggcc ttcgttctcc ttcaaccatt tgtcgatatt aattggtgta 471661 gtattaaaca tttttttcga tttttttggt aaatgtatgc tatttcagtt acttgtagac 471721 tgtcgtgaaa agaataaaga aagaatcttt tacgtccgtt tttttacttt gccgaatatg 471781 tttcagtgac tcacaattta tcctgacgcc gtcacaaagg cagccattcc attgcaataa 471841 cgacactctg aatattcacg aacgttcacc agacatttgg aggcagcgtt ctaaatgccg 471901 atacccgttc aggagtacag gtgtcagtga cagaaaaata atggcaccgt tgacgtcgaa 471961 aatacatccg cgcaaatttt gacaggctat tttggcagcg caatcaaaga ataaacttgg 472021 tatagtaagg aagccagtta ctgtacgcat gaattacggt agcttttttt attttattta 472081 tttttttttt ttttggacaa atagaaaaat ttttattatt atgtaagatt attgaagtaa 472141 aaatacaatt ggacgaatct agttagattg ccaagatgtg ttaaaaggca agattaactt 472201 atgaacatga tctacaacgt cctggttttt aaattcgagt aaatacgcct cctttttatc 472261 tgtgaatgac agtcctgttc tcccaagtct ttttacatca tggagacggg agttatactc 472321 tctcgggtac aaggttcctt cagcatcaga acagatcaca aactttatcg caacaacaat 472381 tcctttatat tcctgggaaa atatgtcggt atagcctact cgagacggct tccaaacatc 472441 agctttcgtt ttaacatgtt gctgttggaa taaaaatcca ctatcgtcta tcaactaata 472501 gttatattat caatatatta tcatatacgg tgttaagatg atgacataag ttatgagaag 472561 ctgtcatcga agttagagga agctgaaacg caaggattga taatgtaata ggatcaatga 472621 atataaacat ataaaacgga atgaggaata atcgtaatat tagtatgtag aaatatagat 472681 tccattttga ggattcctat atcctcgagg agaacttcta gtatattctg tatacctaat 472741 attatagcct ttatcaacaa tggaatccca acaattatct caacattcac atatttctca 472801 tggtagcgcc tgtgcttcgg ttacttctaa ggaagtccac acaaatcaag atccgttaga 472861 cgtttcagct tccaaaacag aagaatgtga gaaggcttcc actaaggcta actctcaaca 472921 gacaacaaca cctgcttcat cagctgttcc agagaacccc catcatgcct ctcctcaacc 472981 tgcttcagta ccacctccac agaatgggcc gtacccacag cagtgcatga tgacccaaaa 473041 ccaagccaat ccatctggtt ggtcatttta cggacaccca tctatgattc cgtatacacc 473101 ttatcaaatg tcgcctatgt actttccacc tgggccacaa tcacagtttc cgcagtatcc 473161 atcatcagtt ggaacgcctc tgagcactcc atcacctgag tcaggtaata catttactga 473221 ttcatcctca gcggactctg atatgacatc cactaaaaaa tatgtcagac caccaccaat 473281 gttaacctca cctaatgact ttccaaattg ggttaaaaca tacatcaaat ttttacaaaa 473341 ctcgaatctc ggtggtatta ttccgacagt aaacggaaaa cccgtacgtc agatcactga 473401 tgatgaactc accttcttgt ataacacttt tcaaatattt gctccctctc aattcctacc 473461 tacctgggtc aaagacatcc tatccgttga ttatacggat atcatgaaaa ttctttccaa 473521 aagtattgaa aaaatgcaat ctgataccca agaggcaaac gacattgtga ccctggcaaa 473581 tttgcaatat aatggcagta cacctgcaga tgcatttgaa acaaaagtca caaacattat 473641 cgacagactg aacaataatg gcattcatat caataacaag gtcgcatgcc aattaattat 473701 gagaggtcta tctggcgaat ataaattttt acgctacaca cgtcatcgac atctaaatat 473761 gacagtcgct gaactgttct tagatatcca tgctatttat gaagaacaac agggatcgag 473821 aaacagcaaa cctaattaca ggagaaatct gagtgatgag aagaatgatt ctcgcagcta 473881 tacgaataca accaaaccca aagttatagc tcggaatcct caaaaaacaa ataattcgaa 473941 atcgaaaaca gccagggctc acaatgtatc cacatctaat aactctccca gcacggacaa 474001 cgattccatc agtaaatcaa ctactgaacc gattcaattg aacaataagc acgaccttca 474061 ccttaggcca ggaacttact gaatctacgg taaatcacac taatcattct gatgatgaac 474121 tccctggaca cctccttctc gattcaggag catcacgaac ccttataaga tctgctcatc 474181 acatacactc agcatcatct aatcctgaca taaacgtagt tgatgctcaa aaaagaaata 474241 taccaattaa cgctattggt gacctacaat ttcacttcca ggacaacacc aaaacatcaa 474301 taaaggtatt gcacactcct aacatagcct atgacttact cagtttgaat gaattggctg 474361 cagtagatat cacagcatgc tttaccaaaa acgtcttaga acgatctgac ggcactgtac 474421 ttgcacctat cgtacaatat ggagactttt actgggtatc taaaaggtac ttgcttccat 474481 caaatatctc cgtacccacc atcaataatg tccatacaag tgaaagtaca cgcaaatatc 474541 cttatccttt cattcatcga atgcttgcgc atgccaatgc acagacaatt cgatactcac 474601 ttaaaaataa caccatcacg tattttaacg aatcagatgt cgactggtct agtgctattg 474661 actatcaatg tcctgattgt ttaatcggca aaagcaccaa acacagacat atcaaaggtt 474721 cacgactaaa ataccaaaat tcatacgaac cctttcaata cctacatact gacatatttg 474781 gtccagttca caacctacca aaaagtgcac catcctattt catctcattt actgatgaga 474841 caacaaaatt ccgttgggtt tatccattac acgaccgtcg cgaggactct atcctcgatg 474901 tttttactac gatactagct tttattaaga accagtttca ggccagtgtc ttggttatac 474961 aaatggaccg tggttctgag tatactaaca gaactctcca taaattcctt gaaaaaaatg 475021 gtataactcc atgctataca accacagcgg attcccgagc acatggagtc gctgaacggc 475081 tcaaccgtac cttattagat gactgccgta ctcaactgca atgtagtggt ttaccgaacc 475141 atttatggtt ctctgcaatc gaattttcta ctattgtgag aaattcacta gcttcaccta 475201 aaagcaaaaa atctgcaaga caacatgctg gcttggcagg acttgatatc agtactttgt 475261 tacctttcgg tcaacctgtt atcgtcaatg atcacaaccc taactccaaa atacatcctc 475321 gtggcatccc aggttacgct ctacatccgt ctcgaaactc ttatggatat atcatctatc 475381 ttccatcctt aaagaagaca gtagatacaa ctaactatgt tattcttcag ggcaaggaat 475441 ccagattaga tcaattcaat tacgacgcac tcactttcga tgaagactta aaccgtttaa 475501 ctgcttcata tcaatcgttc attgcgtcaa atgagatcca agaatccaat gatcttaaca 475561 tagaatctga ccatgacttc caatctgaca ttgaactaca tcctgagcaa ccgagaaatg 475621 tcctttcaaa agctgtgagt ccaaccgatt ccacacctcc gtcaactcat actgaagatt 475681 cgaaacgtgt ttctaaaacc aatattcgcg cacccagaga agttgacccc aacatatctg 475741 aatctaatat tcttccatca aagaagagat ctagcacccc ccaaatttcc aatatcgaga 475801 gtaccggttc gggtggtatg cataaattaa atgttccttt acttgctccc atgtcccaat 475861 ctaacacaca tgagtcgtcg cacgccagta aatctaaaga tttcagacac tcagactcgt 475921 acagtgaaaa tgagactaat catacaaacg taccaatatc cagtacgggt ggtaccaaca 475981 acaaaactgt tccgcagata agtgaccaag agactgagaa aaggattata caccgttcac 476041 cttcaatcga tgcttctcca ccggaaaata attcatcgca caatattgtt cctatcaaaa 476101 cgccaactac tgtttctgaa cagaataccg aggaatctat catcgctgat ctcccactcc 476161 ctgatctacc tccagaatct cctaccgaat tccctgaccc atttaaagaa ctcccaccga 476221 taaattctca tcaaactaat tccagtttgg gtggtattgg tgactctaat gcctatacta 476281 ctatcaacag taagaaaaga tcattagaag ataatgaaac tgaaattaag gtatcacgag 476341 acacatggaa tactaagaat atgcgtagtt tagaacctcc gagatcgaag aaacgaattc 476401 acctgattgc agctgtaaaa gcagtaaaat caatcaaacc aatacggaca accttacgat 476461 acgatgaggc aatcacctat aataaagata ttaaagaaaa agaaaaatat atcgaggcat 476521 accacaaaga agtcaatcaa ctgttgaaga tgaaaacttg ggacactgac gaatattatg 476581 acagaaaaga aatagaccct aaaagagtaa taaactcaat gtttatcttc aacaagaaac 476641 gtgacggtac tcataaagct agatttgttg caagaggtga cattcagcat cctgatacgt 476701 acgatacagg tatgcaatcc aacactgtac atcattatgc gttgatgaca tccctgtcac 476761 ttgcattaga caataactac tatattacac aattagacat atcttcggca tatttgtatg 476821 cagacatcaa agaagaatta tacataagac ctccaccaca tttaggaatg aatgataagt 476881 tgatacgttt gaagaaatca cattatggat tgaaacaaag tggagcgaac tggtacgaaa 476941 ctatcaaatc atacctgata aaacagtgtg gtatggaaga agttcgtgga tggtcatgcg 477001 tatttaagaa tagtcaagta acaatttgct tattcgttga tgatatgata ttgttcagca 477061 aagacttaaa tgcaaataag aaaatcataa caacactcaa gaaacaatac gatacaaaga 477121 taataaatct gggtgaaagt gataacgaaa ttcagtacga catacttggc ttagaaatca 477181 aatatcaaag aggtaaatac atgaaattag gtatggaaaa ctcattaact gagaaaatac 477241 ccaaattaaa cgtacctttg aatccaaaag gaagaaaact tagcgctcca ggtcaaccag 477301 gtctttatat agaccaggat gaactagaaa tagatgaaga tgaatacaaa gagaaggtac 477361 atgaaatgca aaagttgatt ggtctagctt catatgttgg atataaattt agatttgact 477421 tactatacta catcaacaca cttgctcaac atatactatt cccctctagg caagttttag 477481 acatgacata tgagttaata caattcatgt gggacactag agataaacaa ctgatatggc 477541 acaaaaacaa acctaccgag ccagataata aactagtcgc aataagcgat gcttcatatg 477601 gtaaccaacc atattacaag tcacaaattg gtaacatttt cctactcaac ggaaaagtga 477661 ttggaggaaa gtcgacaaag gcttcattaa catgtacttc aactacggaa gcagaaatac 477721 acgcgataag tgaatctgtc ccattattaa ataatctaag ttacctgata caagaactta 477781 acaagaaacc aattattaaa ggcttactta ctgatagtag atcaacgatc agtataatta 477841 agtctacaaa tgaagagaaa tttagaaaca gattttttgg cacaaaggca atgagactta 477901 gagatgaagt atcaggtaat aatttatacg tatactacat cgagaccaag aagaacattg 477961 ctgatgtgat gacaaaacct cttccgataa aaacatttaa actattaact aacaaatgga 478021 ttcattagat ctattacatt atgggtggta tgttggaata gaaatcaact atcatctact 478081 aactagtatt tacattacta gtatattatc atatacggtg ttagaagatg acgcaaatga 478141 tgagaaatag tcatctaaat tagtggaagc tgaaacgcaa ggattgataa tgtaatagga 478201 tcaatgaata taaacatata aaatgatgat aataatattt atagaattgt gtagaattgc 478261 agattccctt ttatggattc ctaaatcctt gaggagaact tctagtatat tctgtatacc 478321 taatattata gcctttatca acaatggaat cccaacaatt atctcaacat tcacatattt 478381 ctcatggtag cgcctgtgct tcggttactt ctaaggaagt ccacacaaat caagatccgt 478441 tagacgtttc agcttccaaa acagaagaat gtgagaaggc ttccactaag gctaactctc 478501 aacagacaac aacacctgct tcatcagctg ttccagagaa cccccatcat gcctctcctc 478561 aaactgctca gtcacattca ccacagaatg ggccgtaccc acagcagtgc atgatgaccc 478621 aaaaccaagc caatccatct ggttggtcat tttacggaca cccatctatg attccgtata 478681 caccttatca aatgtcgcct atgtactttc cacctgggcc acaatcacag tttccgcagt 478741 atccatcatc agttggaacg cctctgagca ctccatcacc tgagtcaggt aatacattta 478801 ctgattcatc ctcagcggac tctgatatga catccactaa aaaatatgtc agaccaccac 478861 caatgttaac ctcacctaat gactttccaa attgggttaa aacatacatc aaatttttac 478921 aaaactcgaa tctcggtggt attattccga cagtaaacgg aaaacccgta cgtcagatca 478981 ctgatgatga actcaccttc ttgtataaca cttttcaaat atttgctccc tctcaattcc 479041 tacctacctg ggtcaaagac atcctatccg ttgattatac ggatatcatg aaaattcttt 479101 ccaaaagtat tgaaaaaatg caatctgata cccaagaggc aaacgacatt gtgaccctgg 479161 caaatttgca atataatggc agtacacctg cagatgcatt tgaaacaaaa gtcacaaaca 479221 ttatcgacag actgaacaat aatggcattc atatcaataa caaggtcgca tgccaattaa 479281 ttatgagagg tctatctggc gaatataaat ttttacgcta cacacgtcat cgacatctaa 479341 atatgacagt cgctgaactg ttcttagata tccatgctat ttatgaagaa caacagggat 479401 cgagaaacag taaacctaat tacaggagaa atccgagtga tgagaagaat gattctcgca 479461 gctatacgaa tacaaccaaa cccaaagtta tagctcggaa tcctcaaaaa acaaataatt 479521 cgaaatcgaa aacagccagg gctcacaatg tatccacatc taataactct cccagcacgg 479581 acaacgattc catcagtaaa tcaactactg aaccgattca attgaacaat aagcacgacc 479641 ttcatcttag gccagaaact tactgaatct acagtaaatc atactaatca ttctgatgat 479701 gaactccctg gacacctcct tctcgattca ggagcatcac gaacccttat aagatctgct 479761 catcacatac actcagcatc atctaatcct gacataaacg tagttgatgc tcaaaaaaga 479821 aatataccaa ttaacgctat tggtgaccta caatttcact tccaggacaa caccaaaaca 479881 tcaataaagg tattgcacac tcctaacata gcctatgact tactcagttt gaatgaattg 479941 gctgcagtag atatcacagc atgctttacc aaaaacgtct tagaacggtc tgacggcact 480001 gtacttgcac ctatcgtaaa atatggagac ttttactggg tatctaaaaa gtacttgctt 480061 ccatcaaata tctccgtacc caccatcaat aatgtccata caagtgaaag tacacgcaaa 480121 tatccttatc ctttcattca tcgaatgctt gcgcatgcca atgcacagac aattcgatac 480181 tcacttaaaa ataacaccat cacgtatttt aacgaatcag atgtcgactg gtctagtgct 480241 attgactatc aatgtcctga ttgtttaatc ggcaaaagca ccaaacacag acatatcaaa 480301 ggttcacgac taaaatacca aaattcatac gaaccctttc aatacctaca tactgacata 480361 tttggtccag ttcacaacct accaaaaagt gcaccatcct atttcatctc atttactgat 480421 gagacaacaa aattccgttg ggtttatcca ttacacgacc gtcgcgagga ctctatcctc 480481 gatgttttta ctacgatact agcttttatt aagaaccagt ttcaggccag tgtcttggtt 480541 atacaaatgg accgtggttc tgagtatact aacagaactc tccataaatt ccttgaaaaa 480601 aatggtataa ctccatgcta tacaaccaca gcggattccc gagcacatgg agtcgctgaa 480661 cggctcaacc gtaccttatt agatgactgc cgtactcaac tgcaatgtag tggtttaccg 480721 aaccatttat ggttctctgc aatcgaattt tctactattg tgagaaattc actagcttca 480781 cctaaaagca aaaaatctgc aagacaacat gctggcttgg caggacttga tatcagtact 480841 ttgttacctt tcggtcaacc tgttatcgtc aatgatcaca accctaactc caaaatacat 480901 cctcgtggca tcccaggcta cgctctacat ccgtctcgaa actcttatgg atatatcatc 480961 tatcttccat ccttaaagaa gacagtagat acaactaact atgttattct tcagggcaag 481021 gaatccagat tagatcaatt caattacgac gcactcactt tcgatgaaga cttaaaccgt 481081 ttaactgctt catatcaatc gttcattgcg tcaaatgaga tccaacaatc cgatgatctt 481141 aacatagaat ctgaccatga cttccaatct gacatcgaac tacatcctga gcaaccgaga 481201 aatgtccttt caaaagctgt gagtccaacc gattccacac ctccgtcaac tcatactgaa 481261 gattcgaaac gtgtttctaa aaccaatatt cgcgcaccca gagaagttga ccccaacata 481321 tctgaatcta atattcttcc atcaaagaag agatctagca ccccccaaat ttccaatatc 481381 gagagtaccg gttcgggtgg tatgcataaa ttaaatgttc ctttacttgc tcccatgtcc 481441 caatctaaca cacatgagtc gtcgcacgcc agtaaatcta aagatttcag acactcagac 481501 tcgtacagtg aaaatgagac taatcataca aacgtaccaa tatccagtac gggtggtacc 481561 aacaacaaaa ctgttccgca gataagtgac caagagactg agaaaaggat tatacaccgt 481621 tcaccttcaa tcgatgcttc tccaccggaa aataattcat cgcacaatat tgttcctatc 481681 aaaacgccaa ctactgtttc tgaacagaat accgaggaat ctatcatcgc tgatctccca 481741 ctccctgatc tacctccaga atctcctacc gaattccctg acccatttaa agaactccca 481801 ccgatcaatt ctcgtcaaac taattccagt ttgggtggta ttggtgactc taatgcctat 481861 actactatca acagtaagaa aagatcatta gaagataatg aaactgaaat taaggtatca 481921 cgagacacat ggaatactaa gaatatgcgt agtttagaac ctccgagatc gaagaaacga 481981 attcacctga ttgcagctgt aaaagcagta aaatcaatca aaccaatacg gacaacctta 482041 cgatacgatg aggcaatcac ctataataaa gatattaaag aaaaagaaaa atatatcgag 482101 gcataccaca aagaagtcaa tcaactgttg aagatgaaaa cttgggacac tgacgaatat 482161 tatgacagaa aagaaataga ccctaaaaga gtaataaact caatgtttat cttcaacaag 482221 aaacgtgacg gtactcataa agctagattt gttgcaagag gtgatattca gcatcctgac 482281 acttacgact caggcatgca atccaatacc gtacatcact atgcattaat gacatccctg 482341 tcacttgcat tagacaataa ctactatatt acacaattag acatatcttc ggcatatttg 482401 tatgcagaca tcaaagaaga attatacata agacctccac cacatttagg aatgaatgat 482461 aagttgatac gtttgaagaa atcactttat ggattgaaac aaagtggagc gaactggtac 482521 gaaactatca aatcatacct gatacaacaa tgtggtatgg aagaagttcg tggatggtca 482581 tgcgtattta aaaacagtca agtgacaatt tgtttattcg tagatgatat ggtattgttt 482641 agcaaaaatc taaattcaaa caaaagaatt atagagaagc ttaagatgca atacgacacc 482701 aagattataa atctaggcga aagtgatgag gaaattcaat atgacattct tggcttggaa 482761 atcaaatacc aaagaggtaa atacatgaaa ttgggtatgg aaaactcatt aactgaaaaa 482821 atacccaaac taaacgtacc tttaaaccca aaaggaagga aacttagtgc tccaggtcaa 482881 ccaggtctat atatagacca gcaagaacta gagctagaag aagatgatta caaaatgaag 482941 gtacatgaaa tgcaaaagct gataggtcta gcatcatatg ttggatataa atttagattt 483001 gacctattat actacatcaa cacacttgca caacatatac tatttccgtc caagcaagtg 483061 ttagatatga catatgaatt gatacagttc atatggaata cgagagataa gcaattaata 483121 tggcacaaaa gcaaacctgt taagccaaca aataaattag ttgttataag cgatgcctcg 483181 tatggcaacc aaccgtatta taaatcacaa attggcaaca tatatttact taatggaaag 483241 gtaattggag gaaagtccac caaggcttca ttaacatgta cttcaactac ggaagcagaa 483301 atacacgcga taagtgaatc tgtcccatta ttaaataatc taagttacct gatacaagaa 483361 cttgacaaga aaccaattac caaaggatta ctaaccgaca gtaaatctac aatcagtata 483421 attatatcca ataatgaaga gaaatttagg aacagatttt ttggtactaa agcaatgaga 483481 ttgagagatg aagtatcagg aaatcatctg cacgtatgct atatcgaaac caaaaagaat 483541 attgcagacg taatgaccaa acctcttccg ataaaaacat tcaaactatt aacaaacaaa 483601 tggattcatt agatctatta cattatgggt ggtatgttgg aataaaaatc cactatcgtc 483661 tatcaactaa tagttatatt atcaatatat tatcatatac ggtgttaaga tgatgacata 483721 agttatgaga agctgtcatc gaagttagag gaagctgaaa cgcaaggatt gataatgtaa 483781 taggatcaat gaatataaac atataaaacg gaatgaggaa taatcgtaat attagtatgt 483841 agaaatatag attccatttt gaggattcct atatcctcga ggagaacttc tagtatattc 483901 tgtataccta atattatagc ctttatcaac aatggaatcc caacaattat ctcaacattc 483961 acatatttct cagttgcctt actttaacag aagataacag aagtgaagaa cttatatatt 484021 ctgatgagtc tttcatatta gccaattctg aattttcagt agatgatcta gtaacattac 484081 gactgaagca tgaagacgaa gataccgttg ataaagttcc tgtggtggtt gagggtgaaa 484141 gggatgatgt ctggctactt tgtaactgat attgtaacac attcaccaac ttagcagctt 484201 gcgcacagcg tatagacagc gtgagatcgt ggagtgttcc aaatacacta gctttgaaat 484261 cagaggaagg aatccgaagt tgaacatctt gtgccgttga tctattgtac ttccaggtgg 484321 gttccaattt cacaaccaat ttacacttct ccttttcgaa gtctttatat acaattagta 484381 aggtctcgtt gtctccggat aaaattaaag acaaacacag catgtcctta ctcaaaggca 484441 cccatgactt gccgttccaa agggaaactt ttaccgaatc gttttcgaaa tatactgctc 484501 ctccagatgt gtttatgctt aacggaaacg atacatacgt ttcatcaacg ttatcgtcat 484561 ggggggttgc tgataccggg gtaactgatt gttgattgcc tggcaaacta aacaatgatc 484621 ttgaatgatt tttgggaata tcgatagtta gattcttttt gttttttgag aagatgctta 484681 gtaaagatga agatttacgc cgataaagcg ttggcttata gaaatcgata tctggatcga 484741 ataaatcttt atctcgttta tcctttccat cttcagaaat tatactctca gaatcgtcaa 484801 tttcagacgc aacactctct attagttcgg gagagacact ctccaggctg aaagtttgag 484861 aagctgttct aatgtttttt aaggtaggtg tgtccatata tttaggcgag agaggtactt 484921 gaatgctctt atccaattca attagctttt cacaacttag ggattcaata tctttcagag 484981 aggtgtcaag atctgaatct tcgctaactg ttgccctctc actcatgatt gacagtgact 485041 cctcgtcagg gtattcatta gaggtctcta ttaaggaaga cagacttccc ggcaaaggaa 485101 ttgatctatg cagtgtgcga ccattgtgta ttgtatctga tatctttaca gagctaatag 485161 gcatatcgtc atttctttta ggagaagtat aatcagggtt gttactccta acataaacct 485221 gttgagaaat tttacttcca gatcgcttgt attcttttgt agctgttgag tcgaaaagct 485281 ttctaataac atgtttccaa tactcttgcc attgaatagg atctttgcaa gttaacctca 485341 atacaatgct attatttatc ggtaccttta gttttgctcc actatcatca agtctgatga 485401 gatcaagatc gccggaccta aatggtcgaa atagcagcga cctcccgaca ttcattaagt 485461 catggtttcc taacgcaagg gattggaaca agttatcaat ggtttgtaat gtgtatggca 485521 ttttttcaga aagaacctca aatatagcta tctccccatt atctaattca aggatttcaa 485581 ctagtttatt attgatcgcc aacttcttta catctagtct gtaatatgct ctatttataa 485641 ccttattgga atcgattggc ggaagattaa tcagggaaac ttcgcctgat ataacgtcac 485701 gaacgcttcc gtatttcagt gagttacagc ttataaagtc atagcaactt ttaaatttgt 485761 atacaaacgc actgattagg gagcctagtc gtacttcatt tgtgacatag aaaatgtccc 485821 tcaacttata ataaaccttg aatagtaata ccgcaaaaag cttttgtgaa tccatcctaa 485881 agtatgacat gttcgcatcg agaagcaaat gcatacatcc aaataaaaga ttatgataca 485941 aatcgagtat ttgcgcatct ttgaataaac tcttgtaaga attcactatg gattgtgtta 486001 gagacatgtc atcatgattt gcagcatgct ttctcaaaat gcatctcaag taaccgctaa 486061 tttttctcat ttcatgacca actttaacca ttgggtccaa gctcgaacca tggtacctgc 486121 tatgggactc acagacaacg agtaatcgtt ttaacagagt ctcgaagctc gcttcttcct 486181 tgttaaataa ttccatcccg tctcccacac aatactaatt tgcttgctcg ttcgtaatta 486241 gaggaacttt tacttggttc atgatgaatt ttaattgaac tgagggtaaa agagtaatct 486301 cgataagggt acatttttat ttttcccatt aagtgaaatt tccttcaaat tattctcgaa 486361 gctttcatgc cattggtgac acgaaaaaaa aatcttgttg tattttatct aacgcgtcgc 486421 gacgcgttag ataaatataa cagtaaatga tggtataaat gccaccgtcg atatttaaat 486481 gagattgctt atatatcgca ttattacctg cgaaaatcta atttacgact ccttgaaaaa 486541 attccatcat actaagtttc ttggtatagt tacattatcg ttggtctact ccttctcgat 486601 ttccctctta gaaataatca actcttgcaa ctgcctttcc accgtaggat catctacata 486661 cttgttaaat acgttaagca ctctcaaaaa agtttcgtta cttgttacgc cttccacaag 486721 ttgacccaag aagattttag aaagaacgga taaaatgcta gtaattcgtt tcatcttgac 486781 atcttggatt tcatccaact caaaaatcgg taataatcct gtctctagta ggttatccac 486841 cgcaactttt tccgtacgta gttgacttgc tcgagataac agaatgttct ctaatgcttg 486901 caatgcttgc atacctagtt cgtcacaggg attgaggcat tgatgggcga gaccttgaat 486961 agcagctata atctcattct tgttgagtgc tgaattactc ctcccaacag tcgaaagtag 487021 gtctgcagtt atattaatgg aacgactaga aagatcaata atagaacggt atggattgga 487081 ttcaggtgct tcacacccat cctcgactga attttcataa ttttgttccc attttgtgcc 487141 aacggcacct gcacatgaca tttcatcaag cagacttaat atgttcataa agttcccatc 487201 atctacaaag atatcaccat tttgaatgta tttttccaaa aatgtgtaga cggcaaattg 487261 gcggtctttg gctgatatta atatccttaa aaaattccaa aattttacat ttttgagagc 487321 ccgctcattg tattttacgt cattgagatg tgtaaacaga tcatttatta cttgcttccc 487381 ccattcactt tcataatatt tagtattgaa gatttcattt tttaccaaaa agtcgtgttc 487441 tattaaatca cttaaaatgt cccgtggatt atcaaatctc gaaaccaaaa acattttata 487501 cgaggcaagt cttgcaatag cctccttgga aaggccatct aaattcgaaa tattaatcat 487561 atgatcagca attagtgctc caaattcttg tccataagaa gcctctgata ttaatataat 487621 ggatatttcc aacaaaaaga gaagttcttg ttcgaaatag ggcgaatttt cactcgtttt 487681 ttcaatcaca agtgaagaga gaagagtttc aatcatctta ggactgacga gttgattgtt 487741 ctcaaagact gaactgagag gatggctagc cttaacgcac tcaaatgctt taatggaaaa 487801 atcgatgtct tcttccgaag gttcttcatc gcctttcaag taagaggcga aagtagacag 487861 aaggcttctg ctcatctttg ccttgcggat cgatatatct ggatctggca atggtagttc 487921 aggaagtttc aagagtgaat gaaagtttgt aaaaaatggt aaattaggtt ccatcaataa 487981 attctcgaat aatttcaaaa tgagttgcac aatctggttc catagtctgg tagaaacaat 488041 gctaggatca cttatttctt taatgatttg aaagtacaat acggtacata actgagcctt 488101 aaagttttgt ccaagtctta tactctggtt actaacggat atcttcgacc cagtgtcttc 488161 gacgaatatc tcgaccaaag gaatactgtc aacatctagc tccaccgctt ttgcgctact 488221 ttgtgccaat gttgtcattt ctcccagatg aagtacagta tcattatatg actggtcaaa 488281 agaaaagtaa tagttgataa atgtacactt actaatggcg tccaagatac gtaatgatat 488341 ttgatcactg gaagcaactg tgaatatttt gaataaagtc ttcaggataa tatctctaac 488401 atttgagaaa attgctttct catactgaag tatgtctatt tgcgctaact tagaaatagg 488461 gtttgtgaaa tctctttgca tctctgtcat cacagatgtt gaggatatta agttattcca 488521 ggcatcttca aaccaccttt catttccatg atgttcttca ggcattacta tttccttaac 488581 tttgatggac gtgtaaattt tatgcaaata ccaacgagga aaatcttttc cattgtagca 488641 tcctcgtaaa ttgttagagt agtcatcaaa agtcatatgg tctttaacct gcgggttatg 488701 tgaatcggta tttaacatga ttatcgaata acttaacaca aacacagagt ctgcatcagg 488761 ctgtacatga atgatgtcat cttctgtcat tgactctgag ccattttttc ctgctttttt 488821 atcctctaac tccactttat cattgctttg atcagcagaa tattttgatg aaaatgcttc 488881 aacgattctt tcaatctgtt gagattcccc tggtaatctg aatttcgtca gcaaaattct 488941 gatcgcttca tcaaccctta accctttaaa atcgaataga tctataaatt cttttaacaa 489001 tgaagttttt ttcggatcac aaagtaatag accgatggtt ttcttattta aacgtccgtt 489061 attgagaaac aaaaatgaag caatgtctct attagaatcc gaatcaatga atcctttttc 489121 aattaacatt tgaatgcctt tctttgcctt ttcattaaat gtttcaacgc ataatatgaa 489181 ttcagtcttt ctgtctctct gtttcaaaat atcaatttct ttctgatttt ttacgaattc 489241 tgccctatca aatctctgca gatcattgta tatattttca ataagcgaaa gtacaccttc 489301 taggcaaatt ggaggaatgt tgttagaggt attaacggcc gccgctggta aagaaaattt 489361 agttagctct tttataaagt caatcgaaag atccgaccta tccaaattac aatcgaaatt 489421 tacaaaaagt tgcaaaaaga aagcgggaga gtgaatccac agtattgaaa gttgttcaat 489481 aattaattcc ctgattgcag gtggtttttg cttactaacg tcaccactga ttgtggtatc 489541 ctctagaatt tcgaatattc tccttaaagt cagttcaatc tgcataggca aataatcacc 489601 caatatcaca accaaactcg tgaataattg taaagttgct tgcaaaagag aatactgggt 489661 agaactttgt ataatgaata aaacactttt aaatattgga tcagaaatta agctgaataa 489721 ccggggatat agaggaaatt tgtcaccgga tatttcaatg gctgcattga ttaactgtag 489781 agataatttc atggccgaag ttgtgtgctt cattctattc tctggcataa ccagtgataa 489841 caataatcca agataatcct ttataactgt tattccgtaa tttggctcga cattttcggc 489901 tttctcagcc gtttcctcat cattttcctg ttcccttatg acctgttgga ctggcttctc 489961 atttttatta tcgtctgcaa cagcactgtc atcatcagtg ctactcaaat cgttatcaga 490021 ggtagtcgta cctataatgt catccttcaa attattgtcg gtgtaacttt catcattgat 490081 atatttttct gtttttgtag gtggatctag taacttcaac tttgtaaata gtttaacggt 490141 tatccctgca attgtaactt cagccgtttt cctcaaaacc tcgcttctct gcgtattaca 490201 tgccaaggaa agtgtcgttt gtaaaacatc gtagattata gtatcggaga gatagtctcc 490261 aaaggaagag gttataatat cgcgtagtaa tgttacaact tttaataaaa cagagtcgtc 490321 cgaaatttgc tttgaagctt caaatctaca atgtgtaagc gcaacaacgg tttccctaac 490381 ggcaatttga atatcattaa atgttttgtt tatgattttt agtgtaaaaa ctttctgcaa 490441 cgagtccaga gccagagaag tagtataacc cgatactgaa ctagcgctga ctatttctaa 490501 aaatggtttc aaaagttcca aggcgtttaa tgaatctaaa cccttcaagt cgttaatttt 490561 tagccgcagc tgtactaaac cagatatcag aggatcatga tagctagaag taggcaaatt 490621 gtggaagctg tcaacaaacg aatcactttg actcaagaat atatcactac ctccgcccag 490681 caacgcggcc acacttgttt gtgatttatc tctggactgc ttgttcatgg cagaacaaag 490741 attgatgcac tctttgacaa tcatcgtagc tgggttcacg gccaaaacag tttccattgg 490801 cacgtcgtgc attttgtata tgaagccgta ttagttaaac ctgggcgctt cttaccaaag 490861 ttgcgaatta acttaactaa gatggttcaa ttctctgtgt aaagtatcca tattaaaagg 490921 tcttagttcc aacatgtaaa caaagagatc tatatattgt tttttttcca atgcgctgag 490981 tgatgaagtg attagaaaat cataaaaatg agaaactgca aagaaaaaaa aagtcgttat 491041 tctgaaaggt gttcggcagc aacaacctac atccaacgcg atgattcaag atccccttgt 491101 atatttagac atctccattg ataaaaaacc aattggtcgt attgtctgca aactttttcg 491161 tgagaaggct cctaaaacaa cagagaattt ttataagtta tgcgctggtg atgttaagag 491221 tcctttgaag gatcaacagt acctgagcta taagggaaat ggttttcata gagtcgttaa 491281 gaattttatg atccaggcag gtgacattgt ctttgggaca caaaaggatt cctcttcatc 491341 gtctgttgga aaaggtggat gttcaattta cgctgataaa gaggaagtga aaaccgatga 491401 tgaatctttc tgttacggga attttgaaga cgaaaacttg ggagagtttg tagaaccctt 491461 taccttaggt atggccaatt taggttctcc aaatacgaac aattcccagt ttttcataac 491521 tacatacgcc gcacctcatt tgaacggcaa gcattctatt tttgggcagg tggttcatgg 491581 aaaatcagtg gttcgcacta tagaaaactg cagggtagat tctgatggag tccctgaatc 491641 agacgttaga atcagcgact gtggagtgtg ggaaaaaact atgggtgtcc cgctttacaa 491701 cgcttctaat gaccaaattg gcggtgacgt atacgaagaa tatccagacg atgatacaca 491761 tttcggtgac gatgattttg gtaaggctct tgaggctgct aatataatca aagaatctgg 491821 gacgctctta tttaagaaaa aggattactc taatgccttt ttcaaataca gaaaatcttt 491881 aaattatatc aatgaataca tgcctgaacc cgacgtagac aaagaaagaa acatccaatt 491941 tattaaccta aagatgaaaa tttacctaaa tttatctttg gtgctcttta atctggaaag 492001 atacgatgat gctatcatgt atgctacgta tttattggag atggataacg ttcctaacag 492061 agatcaagca aaggcttatt atagaagagg taacagttac ttaaaaaaaa agagactaga 492121 cgaagcttta caagattata ttttttgtaa agagaaaaat cccgatgacg aagttataga 492181 acaaagaata gaatatgtca ataggctcat agaagagaat aaggaaaaga caagaaagaa 492241 tatatcaaag tttttctcct aattagttac ttgtaaggct gaaatttgag attaaataac 492301 ccaatatgaa aacactacat taataagatg taattatttt tatttataaa tccatttatt 492361 tgataaaaaa tatgatatca tacaaagtca tctagtaagt tcttggtaat agcagatttt 492421 tttggcttct gtggcttttg tgatgaaaga tcatctaata tgtccttaga gagtttatct 492481 ttcctatttt ctgagttgtc tgtttcaccc acagagtcgt ttggcgcttt tggagttaaa 492541 ttctctttat gctgagaata tgaaggagag acgaactcat ccagtatact tctaggtgca 492601 gaagaagaac tttgagcgag ggaatttgaa gaagtgctat ttggtggtgg ttgcaagaag 492661 tcgtctaata agctatttgg taactttgga ttaggtgact ctatatctga agcacttggc 492721 gagccaaact tatcaaaaag actgggcctc atcctagcag tagaaattgg ttcagacgcc 492781 atggcgccaa tagcagaata tgctctatcc ttggtggggc tctttaatag cttctgaact 492841 ggtatggaat ttctttcgat gaacttccaa ttcttcacaa gtgaaaccgc caggtaattg 492901 caacccattc ggcaaagaat atcagtaact cttaagatca gagtacactc gatttttgct 492961 tcaacattta gagatccaat gaaatacttc aagtttctgt ttctcaggtg attgtataga 493021 tagagcaaag cagggtcttc aacaaggaat gatctgttaa cacagacttc cttatcaaca 493081 atgcttgagt tgttttctaa atcaatcgga gcagtcagca aagctttaat agccacttcc 493141 tgctttctca atttccagta aatgaaactt gctttccatc tatcattctc ctttattgtt 493201 tcaggtagca tttgcgctgt caatagctct cccaacacgg gtccattatc accttcataa 493261 acacgacata caccgattgc caaatccata tcatgcactt gcttgcaaag aacgttgaca 493321 caatctttta gagagtcagt taagagaaag aaaactgctg catccatata tctatgctta 493381 cttagcagaa caaaagcatt tttgagtgct gccgttctcc acctcggtac agtgaaatca 493441 ttactgataa atctaaccat cttttgctgc tcaggatgac caatagccat cttccacaag 493501 ctcaatagta tctgtttttt cttcaacgca agataaaaaa tagcacaacg gcttggatcc 493561 ctcttatcat ctttggaaaa ttcatatttt gcaatatcct cgaatttctt caccaagtcc 493621 tgctccttaa tccaataggc tattctatat tctcgagcgc gattccatga ggttatgtgg 493681 cggtcaatag aagataataa tatttcttta ttgtctgagt gcaatgccca agacacatcc 493741 ctcatcaata tgcttttttg aatattttta tgtgataaaa ataacttcac gcccaacaag 493801 aacctaacac cgttgtaatc tactatattc tcatttttgg tgacttcatc cactgcttca 493861 atgactgtga taagcgtgat ctgctggtgg cgggttagat aaggcaaagt tgttttcgtt 493921 agttgctcag taagtgctag agacactgtc ttattgaaac aggggtatgg atcagggaaa 493981 gattcgaccg gatagtctct atctttagca ataaagtact ttaatggatc cattcctaga 494041 ttggaatcca aattagatac atcttgcgat tcaaagtcta attttcttaa cgctaaaaac 494101 aatcttaata acagctcctt gacaagttgt aacttattcg cataaatggc ttgaatcaaa 494161 aattgtggat gataaactgg aagtggacca tttaaaacac tacttaaatg gagaatatca 494221 tttgataaaa tttttcttga accaattgat tggtacgtaa atggatcagt caaatccaga 494281 gatttatcct tgatgtaaaa ttgatttccg gaagcaacaa caaacgtgcc atttttcatc 494341 catacggagt cacctatatt atgagctgta tgtgctgtga tatcaatttt ttcaataggt 494401 aggtaactag gtgtgttgtt cgtgtaatca taccttaatt gagtataaag taaagcgtat 494461 cctgtaaatc cgatagagac aatgctttgg ccatattccg tgcttgtcca atctatatcc 494521 tcgataggat tatgaaatgt ttcttcgtat tcaagaactc ccctgttcag gtcccatagt 494581 gacattactt taccagtaga attaacaata cataacttac ctgtagatga tcctctaata 494641 catgtacaat tcattattcc ggtgttaatt tcacatgcct tgatccattg gacatgccta 494701 tcattataat taacgatggc tttatacgtt ctggtaagac cttttttagt aatcaaagaa 494761 atcaaaggcc tgttactcac aaaagtttga tgtacagggt caataatgga gatcttgtat 494821 atgtcgtcac catcgatatc taatgaatca gactttactt caaaaatacc acgtgttaaa 494881 gagacttcaa aagctttgat tgaaccatca gagaatatta acgcggtgaa atgacgctca 494941 tgactatgct ttggctcagg tgtatttaac ataactattg gatggatttt tttctcctct 495001 ttcagtctcg tttccacacg taaatatgat tgcttctgtt cactgtcctc cttacgattc 495061 gttggacatt cccaggcttg taaagcccca ttttcgagaa gacagatgac ctgtttaccc 495121 aactcatgta caactgcaaa ttttatggga gattctgttt gtattgtatt ttgtaaccgc 495181 agtgaaaccc catggtttaa cttttgtggg taccaaacgc cattttctga gaatctcgaa 495241 gtggttaata aagcttcgcc gtcgctgctt cttaccaact tctgcacaga tttgttatgt 495301 cccgtaaatt tgtgctctaa agcggcactc agatcttcgg ttttattgtt tataagctgc 495361 agaatgtcga ttagtaaatg tctgattaca ccttgtaaat cgtggacgag aaaagaaagt 495421 ttgcccttca cattgtcata gggttgtatt tcggggaggt acaaatatct tgtatcgttt 495481 agcatagttg ctttcttgac ttttttatgg gaaatggtct ttttagtcat tggttttgga 495541 ggatcttggg aaagattatt caaagccaaa acttccattt ccccagtcat tgaacccaga 495601 ataacaatgt ctgagtcaga tatatcaaag atttccgagt ctttcacact gagagtttgc 495661 ctaatgatcc aattgtctat tatcacgcag aacttctgcg tgggggaaag aggcacttca 495721 ccccatattt gcacagtatg gtttttctcc atttcaaaac aagaccatat tctcagaact 495781 ttatcttcac acagcgtata aagagcatga gaggcagtgt tgtttttact cacctggtct 495841 ggctcttttt tccaccgcat tgcagttata ggtttcggat gaggcaacat agtaaggtta 495901 aagatggctt gttctccgac tattgaaaca cgcttccata gtttagcatt acagtcgtac 495961 ttcccaatac tgactatcag ctgcgaatct tgtgatataa tcacattata aacaggttta 496021 ggctgttttt ggttccactg caaaataggt tgatacacac caaaattatc cttaattttc 496081 caaaaagaaa gaaaatcaga tccaatggct aactcattat cagaagacca tcttaggcag 496141 tttactggcg tgtcatcatg gaacaactgg caacattggg tccacttggg attctgcata 496201 atttgatgaa tgggcttgta gatgagcacc ctattgtgga aggaaagggc aatgaatcca 496261 ttctggctgt taatatcgac cgcagtacag tctgattgtg tatatatggt ctgtaaccta 496321 gtgaatttgt tggtaagtat gattaaatta ttccctgaac aatatgcaaa gatggtatga 496381 ttttgccatg ttgcttgaca agctgtctga ggggtagcat tggggcgtcc tggaagaaag 496441 ttcaatgaca tgagaactac ctttgcgtgt gcacgtttgt ttactttctc aattgtttgc 496501 ggtgttctta gatcccttta attattaaaa aaactgaagt gcttgaaaca ataacataac 496561 gaggtttcgc tatgcgggca gctttaaaga aagagggata gtatattaaa aggctgccat 496621 aacaattaat cggaacagaa tagacacaaa taaatttgca gtgcgtttgt agatatcaaa 496681 gaatggtagc tagttgtaaa gatcagaaga aggctgtcgc tatatgtttg cagagatcgc 496741 cctgtgtcat gatagagaga cataaccctc aagaatgtct tgacaatcca gagctgaata 496801 aggatctgcc cgaactttgt attgctcaga tgaaagcatt tttggattgt aagcgaggaa 496861 tcgtcgacat gactaagcgg ttcacaggta acgcacctct gtcgactggc aagtacgatc 496921 aacagtacga aaacttgtgc aaaggaaagt ttgatccgag ggaggagatg gaaaagctaa 496981 aacttctgaa cagccagcag aaggactgat tatttatgaa aattggcctg taaatatata 497041 cataaataaa tatatgcgtc aagctctttt attcggtttg tccagtaatc ctcttacaat 497101 atatatatat atatatacgc atgtagcgta ttcaagaaca ttacatttaa aaaatagagg 497161 gtagaacaat aaaaatgcac ttaacaagtt ccgtaagtag aaattataat cagtctaagt 497221 acaaatttat accttagctt catttcagtt aagggcgatg caataaaagt ggaagaaaaa 497281 aaaagaaggg aagaggtttg ataatatata tatatatata tatataacat tgctcagaga 497341 aacatacatc agtgatggaa gataaagagc agcaagacaa tgcgaaactt gaaaacaatg 497401 agtcactaaa agatctggga gttaacgtgc tttcccaaag cagtttggag gaaaaaatag 497461 ctaatgatgt aactaacttt agcaacctac aatcgctgca gcaagaagag actcgtctag 497521 aacggagtaa gaccgctctg caacgttatg tcaataagaa gaatcatctc acaaggaagt 497581 tgaacaatac cactaggata tctgttaagc agaatctccg agaccagatc aagaacttac 497641 aatcagacga tattgaacga gttctgaagg acatagacga tatccaatca aggattaaag 497701 agttgaaaga gcaggtagat caaggtgctg aaaataaagg ttccaaagag gggctgcaga 497761 gacccggtga aactgagaag gagtttttaa tcaggactgg taagatcact gcatttggac 497821 acaaggctgg tttcagcttg gacactgcaa acagagagta tgccaagaat gacgaacaaa 497881 aagatgagga ttttgaaatg gcaacagaac aaatggtaga aaatttaacg gatgaggatg 497941 acaatctcag cgatcaagac tatcaaatga gtggtaaaga gagtgaagat gacgaagaag 498001 aagaaaatga cgataaaatt ctcaaagaac tggaagacct gcggttcaga ggccaacctg 498061 gtgaggcgaa ggatgatggg gacgagttgt attatcaaga aaggttaaaa aaatgggtga 498121 aacaacgttc ttgcggtagt caaaggtcat cggacttgcc agaatggcga agacctcatc 498181 cgaatattcc cgacgcaaaa cttaatagcc agttcaaaat acccggtgaa atatactcgc 498241 tgttatttaa ttaccaaaag acgtgcgttc agtggctcta tgagctttac cagcagaact 498301 gtggcggtat tattggtgac gaaatgggtc tgggaaaaac gattcaagtt atcgcattta 498361 tcgcagcgtt gcatcattca ggtctattaa caggccctgt attaattgtc tgtcctgcaa 498421 ctgtgatgaa gcaatggtgt aatgagttcc agcattggtg gcctccattg aggacggtca 498481 tattgcactc aatgggttca ggaatggctt ctgaccaaaa atttaagatg gatgaaaacg 498541 atctagagaa cttgataatg aattcaaagc caagtgattt ttcttacgag gattggaaga 498601 actcaacaag gacaaagaag gcattggaat caagctatca tttagataag ttgatagata 498661 aagtcgttac tgatgggcac attttaatta ccacgtacgt tgggttaaga atacattcag 498721 ataagctact aaaagttaaa tggcagtatg ctgttttaga tgagggacat aagattagaa 498781 acccagattc ggagatttca ttgacttgca aaaaactgaa gacacataat aggatcattc 498841 tttcaggaac accgatacag aataatttaa ccgagctttg gtcgcttttt gatttcattt 498901 tccctggtaa attaggaact ctacctgtgt ttcaacaaca gtttgtcata cctataaata 498961 ttggtggtta tgcaaacgca acaaacatac aagttcagac cggctacaaa tgtgctgttg 499021 cattgcgtga cttgatttca ccgtacctgt tacgtcgtgt gaaagctgat gttgcaaaag 499081 atctgccaca aaagaaagaa atggttctct tttgtaagct tacgaaatat caaagaagca 499141 aatatttgga gtttctgcat tcttcagatt taaaccaaat acaaaacggt aagagaaatg 499201 ttctatttgg tatcgacatt ctaaggaaaa tatgtaatca ccccgattta cttgacagag 499261 atacaaagag acataatcca gattacggtg atcctaaaag atccggaaaa atgcaggttg 499321 tcaagcaatt attattactg tggcataagc agggctataa agccctactc ttcactcaat 499381 cgagacaaat gctcgatatt ctagaggagt ttatatcaac gaaagatccc gatttatcac 499441 atttgaacta cctacgaatg gatgggacaa ctaatatcaa agggagacag tcgttagttg 499501 accggtttaa caatgaatct ttcgatgtat tcttactaac cacaagagtt ggggggctag 499561 gtgttaattt aaccggtgct aatagaatta tcatttttga tccagactgg aacccatcta 499621 ctgacatgca agctcgagaa agggcatgga ggattgggca gaaaagagag gtatcaatat 499681 ataggttgat ggtaggaggt tcaatagagg agaagattta tcatagacaa atattcaaac 499741 aattcttaac caacaggatt ttgactgatc ctaagcagaa acgatttttc aaaattcacg 499801 aactccatga tctgttttca ctggggggtg aaaacggtta ttctacagaa gaattgaacg 499861 aagaagttca aaaacatacc gaaaatttaa aaaattccaa atcagaggaa agtgacgatt 499921 ttgaacaact ggtcaaccta tctggcgtat ctaaactaga aagcttttat aacggtaagg 499981 aaaaaaaaga gaatagtaaa acagaggatg atagattaat cgaagggttg ctaggaggag 500041 agagcaattt agaaaccgtt atgagtcatg attcggttgt caattcgcac gcgggcagtt 500101 cttcttcgaa tataattaca aaagaggctt ccagagtagc gattgaggcg gttaatgcgc 500161 taaggaaatc gagaaaaaag atcactaagc aatatgaaat tgggacacct acttggacag 500221 gtaggtttgg taaagcaggt aaaattagaa agagagatcc gttgaaaaat aaattaactg 500281 gatcagctgc cattttaggc aatattacaa aatcacaaaa agaggcatcc aaggaagctc 500341 gccaagaaaa ttacgacgat ggtataacct tcgcaagatc caaggaaatc aattccaata 500401 ccaaaacgct agaaaatatt cgggcatatt tacagaaaca gaataacttt ttctcatcta 500461 gtgttagcat acttaacagc attggcgtca gtctttctga taaagaagac gttattaagg 500521 ttagagcatt attaaaaacc atagcacagt ttgataaaga gcgtaaaggg tgggtgcttg 500581 atgaagaatt taggaataac aatgcttcat gaaaacttag aatggacaga gtacccttga 500641 cgtaacttta cccatagaaa tatctataaa aaatatgtat gtgttatgtg tatatgtata 500701 ttctgaagac tcttagcgga acccgtaacc ttcagattca ttaattgccc aaagtaattt 500761 cagttctagt ttttttttcg aggaataatt ccataaacat atttcattaa aacatgtatg 500821 agccaatggc aaatcatcac tatcatgcga ccctagcaag ctaattttga atgggatagt 500881 agagataccc gttgcaggta tacgatcaga tgccgttacg aattgtaata atttcttctg 500941 caatggatag tcccaacttt caataatttc ccaaaaccag caaaccgctc tggaatcatc 501001 ggagaagcca cctacatact ttgtcacgga tcttaacgat ttgaaatcaa atttagtttg 501061 ttcctcatca ccacacacta atctctccag ctcttcagaa ttaaataatt ttatagaatt 501121 gcattctgcg aagacccttt taaaacctga aacaaattta ttgtattgtg gctcaatgga 501181 cttttccaga taaaattcta cccatttcat gacaaactca tgcttgttac tttgggttat 501241 tggcacattt ctgccatttt cacataattc taccgttaca tactctttgc tcgatttact 501301 gtcatttaaa atccagttgt tatttcgata cgtagtctca aatgttaaag aaaagacgtc 501361 ttcgaaatta tcctctgtgt aattgagcat ttttattaag ttcctacttg tctccggaaa 501421 caattccgag taatcttcaa aactcagagg ctctgagcat agttttttat aaagcgcctt 501481 tggaaattgt aaatctaata tggtactgtt gaaaatcgcc aaccccatga caactccaaa 501541 caagtaatat aattccagtt gtgagttttt tccttttgat ttgtcaaaat ttggagggtc 501601 aatggcaaac catgaacgtg agctttcttt tatgtaaata aataagccat tcatcggatt 501661 aaacagcgat tttgttaata agaaaaacca ttcttttctc aaccctcccg catcaattcc 501721 aggttcatta acaaactcta ttctcagcga ttttaataaa tcgccttgat gttccttgat 501781 acatctcaat gaatcatgag aaataacgtc acgccgtact ttgattttga aataaacgtc 501841 tacggatttg cctttatcca gtgaaattaa aaaagcctgt tcagcttcat gttccatgat 501901 tctgcgaatt tcatactcca taatagagat tttgatgccg agtgacaata taaatggata 501961 cttacagaat gaaaaacatt tttttgtcgt cgaatttccc cactcttcaa tcagttgatt 502021 catttttgtc ttttgagcta ctcctctcca atgatcgaaa tcttgtttat aatctatgaa 502081 gtctagcgtt atattgtaaa agctttgaat tgacaacgct ccacggccat ttcttctagt 502141 attggctaca taatagatga acgtcaattt tgctgcagag tgaatatgcc agtcttcctc 502201 atattgaaaa aatttaaatt tcatcttatt attgacggga tgcgtgaaac cacttccctg 502261 tttatcattt gattgtgcac ttattggtct agtactcagg aattcatggc cagtagtgtg 502321 atgccgacga agacgagatc gcatctcatc ttcaggcttc acgttatttt ttgcggttct 502381 atttgataat tcgttcgaca gtaatctgga aaattggaaa ttgatgtata aatttaaaat 502441 ctctacctgg tatgaaaaat tatccgtagg cgttcgccgt aatgattgaa tcaattgttg 502501 agatgttttt gttgataggt tagacaagta gccaatacat cgtttggcca actcataaga 502561 caccgccctt atttgttggg tctcaaacac atttttgctc ttccgatctc taataaggca 502621 ggttcgtatt gtaggtatat ttaatataat cagcaaccaa cgatactgta atatttgcaa 502681 attttcccct ttattgattg ttattctctt cagtagatcg ttacagcaac acagcatact 502741 ataatacggt ttccttgtag gaagatttga taatatactg taaaatcttt gtaaaacttc 502801 ataattcagc atctttatat tctttccacc atcatgtacc aagaacgacc tgtttaaaat 502861 gctaacatca tgaaatctgt ccagtaaata cgttattacc ggttggaaaa tcaacccctt 502921 tctttcttta tccagaatcc cagtcttctt aagccgctgc aaatcatcat ggcaccgcct 502981 tactaccatc tgcaaaccct ctaatgtgca cgaaatatgc gtactagatt ccaaattact 503041 gttaatttcc ggctccttta caataactgt tacttggcat gcgctgcatc gaaatttcgt 503101 tatggaggct ggaaaccgta gtgggacacc acaacatagg caattaagtg aaattagaca 503161 ggatttatct tcttcccctg acacggatgc cgaagagttc cgcttattgc ttttgctatt 503221 tgagcaactt ccgtccttta cactagcggc taaggaccgt tccgacgtgc gccttcctga 503281 tttgggtaac ctgttcttag tatgggctac agaatgtgat agcaactcct tcgacacaga 503341 tccatctcta ccgtcttttt ttgcattaag cttatcaaat aaagaaacca tttcctattt 503401 tactttacct atcagccgca gtattcgaga gatatacctg gtaaatttca ccaatgccct 503461 taaaaatatg tacttttctg cttaaagtcg agaaatgcat gcaaaaactt gcccctatct 503521 agcaatcctt cgaatatatt tatctatcta cctgttccac atgggcggtt atacctgact 503581 cttcaaaaaa tcctgtaacc tccatttttt tcctttattt ggggcaatca caaaaaaagg 503641 gtcccagaaa gatatgaccc tactcccttt ttgccttatt taaaagtgct aggagataca 503701 aggttaaagc tagacctcgg ttaacgatgg gtcttgacac gtaggcgttg ctctcctctc 503761 cataatcata gtaagttgag acaatcgtat acctccaaag gaagcacttg ttggcttgac 503821 aagagactca tgatagacag gaacgagagt cagggtaatt ggatagtgga aagatgaaag 503881 caagagaaac gatgcaaaga ggaggctgcc cagggcttgg cgtatccaat ttctcatgcc 503941 agcagggagg attcgtatag cgatgactga caacattata gtaagtgagg ttgatggtcc 504001 cccggatgta gttaaatgtt ttattaggga agaagatgga ctcgaaggac agagccgaga 504061 attggtggtc ataggactag aatatataga tgtgtttgaa ggggtagaac aagatgaagc 504121 gcgcaagaag ttaagactta ggactgtcgg atatacaatg gcagcctttt atttcaaaga 504181 tcatactgca cctaaccgaa gattttatat tctgttgaaa gccacgggac ggttggactt 504241 cgtcaacctt gattacaaaa tagtgaaatc tctggaaaca ggaattgatc aggtaagatc 504301 agagccaaag ttcatgttcc aagatccact acgaacagct ctggttttta atttgtcatg 504361 cactgaaatt tacgagattt ctactgagga cattttttgt ttggaagaaa cagacgttaa 504421 gctgagttat gtgacatcct caccgatagt atccatagat gcgtgtatca atttcaatga 504481 tttcttagat aaggatgtct ttacgttgtc gattctcaca cgtgcacaca atgaggttgc 504541 atataagttg gaagcatgcg tgtgtgtatt cgagtctaaa ccagccaaag gaacgaagtg 504601 gcaaagaact accaatttaa catttgtgga ggaagcaacg gtctcacaag tacttctcaa 504661 atcggtcacc aatattggtc attttgtttt tacgccatgg aaaacttatt ttattaaaca 504721 tgcattgtca tcgaaacaga ccattgatgg taaaacggta gacaaaatat accaagggcc 504781 tggtgccttt gggtctgata acatggaaag aatcgaactt ttgcagccta ttttagcgga 504841 taccacatta aatcatttaa catttacatt tatgacgagt actgcaattc taataacatg 504901 cagaatgaat gcaatcctta gcagttttga agacgatacg tatatctggg aaaaggcctt 504961 gtttgagagg cttcccatca atggtggttc ctcacatgat cactaccttg cagcgttttt 505021 caatgagaag tgttggatac tggtatcccc aaagggccat cttacagtat attcagtcag 505081 aaatgaaggg catagtaatt ttgttcatct tggttctttt ctttgcaaat caaccttata 505141 ttccgatttg atagggaact acaccaagtc acatttatct tgtggatcat tacactgtgg 505201 gcagggatac ttgtgcttga aatttcgatc gtgtggggac attttcgcgt ccacttgcat 505261 gaagctactt ttcaaaagta aagacagtgt tcctcgacaa gtttactcta caagaaaagg 505321 tatctattgg gcagatgtga ataataatgt ttacagagat agtgagcgaa tagactttga 505381 aataaatggc agtttcattg ctactaaaga tggaactcta ttgaaagata acactatcgt 505441 tactttggtc ccaattcaaa gagataatga gtgtaattac gcatacgtca caaaacaagg 505501 ttatctgagg tggagttttt caaaggttta ttaccggatt caaaacacgg gagttgattt 505561 gactatagat aattgctttt tatctgctat atctagcaag ggctcttttt tgactgtact 505621 tgttctgaat gatgaaataa cggtatttga tcattgcaac cgtttgaaaa gccagaaagt 505681 agttttccat agactttctg acttagcgtc cattttccta tatgaatacg aaagcacggt 505741 ctacattttc atgtctgaca ccgaaggaaa cctttgcgtt atgaaattgg caacttttga 505801 gatcgtagaa gaggttaaaa tttgcaagaa gaagttacag ttctgtgaag tccctaactc 505861 agattatttt tttatatata cagccgatac tataattttt ttcaagccaa gtaaaataaa 505921 aggtagattt aaaatccaag aagtatatgc accatgtcct ataagctgtt tgatacctgg 505981 agaaaaagat ggctcagttg ttatggttac ttctcaaggt caattttacg acgtacttgt 506041 tcctggtgat gccggaaggg ctactctttg ttctaagttt gaaaaagttt taaaaacatg 506101 tctcaaattt ataactttgg aatcttcatc aagatatgtg attgtagcgg ccctgccagt 506161 agcaaatcca ttgcaggaca agtattccga aatttatgtg tatgatatta aacagttcaa 506221 aaacatttcc gcattcaatt tttctaacct caacaatgat atcgagagta taaaatatga 506281 aaacgctatg atatcagata ttattgccgt acccatgctc aaaagaaccg aaacattagg 506341 aaaaagaaag acttctgagc tgtataagga agtgattttc aattcatgta tcttggtgtc 506401 tctaaattta gactcaatag acggtattga tagtaaaaat atgaataacc tattattgtt 506461 ttcatttgat gaggaatcgg gttttattga atttgttttt gggattaaca cggggttctc 506521 aatcagtggg ttacataact attacaatgg atgtgttttg gtttatgggg agtttgtgca 506581 agcttatcaa ctgaactatt cagttcatga taacaagttc agtattgaac aggtttcaaa 506641 taggttgaat atttctggta ttacaataac atcatctata ttttttgata aaaggaaggc 506701 aaagatggct aggaagcagc aaaatatagg tacatgggtt tatttggaag aaatgatttt 506761 acttgatgta cggaaaggtg tgatgaggtt caatgtcatc catacaacag acggtaacat 506821 agaaaaggtt caattgcagg tacagcctct gaatttattt gagagggacc tcatcaatag 506881 cattaccgac accgggaaaa tgtttaccgg tgcagccgct ataactttca agaatattag 506941 gtatctacta atttcgtacg gtgatcaaaa gctcacgtta tttagtttaa aacttgatgg 507001 tgaggaagaa atagacgaaa gagtgtacca tgttgctgag caagttacaa ccatcaactc 507061 tgtaagaact actgattcca gaatgagcac gtttttaggc gaatctacat ttatgccctt 507121 attcttagta agtaccttgt ctaacggttg ttatgtgatc ggaatcctgc atgaagagtc 507181 agatatctca ttacatatct tatcagaaaa gaaagctgtc ttcgcaaagc ggtcggttca 507241 aaagttcctg ggcttcctcg atcctcaaat ggatgatcac actgtaatat ctgaaattta 507301 gtgtctacgt tatgatatat acacttacaa atttactttc cttttttagt atagttttca 507361 agtaaaattc ttgaagcggt gttgtttttg tttgttcttc gtttagcaaa agtcattgtt 507421 aaatacacgc tataatatgg ccatgaccgt aggaccgaat gctgtccgaa aaatgatact 507481 tatcacacat ttcaaataag atcggttttg tagttcaaag atttcttaag agccttttac 507541 gtgtttctta agaaacactt cacattggct atcattatta gtaaatagat ttatatgatt 507601 ttcacttatt aaggacagaa atgtcgcgat ttcgaaccca taaaaaaagg aaaagcaccg 507661 cctgttctcc agtcttcata aaagcacacc gtatagaaag ggcggtgaat gttgatcttg 507721 catactataa aattatttga cactaatgcc aacaacttat gtgccaataa atcaaccaat 507781 tggggatggt gaagatgtca ttgacaccaa tcgattcacc aatattccag aaacgcaaaa 507841 ttttgaccaa tttgttacaa ttgataagat tgctgaggaa aatagaccac tgtctgtaga 507901 ctcggacagg gagttcctta attcaaaata tcgacattac cgagaggtta tatgggaccg 507961 tgcaaaaaca tttatcacat taagctctac ggccatagtt attggatgta ttgctggttt 508021 cctacaagtc ttcacggaaa ctctggttaa ctggaaaaca ggtcattgtc agaggaactg 508081 gctacttaat aaatccttct gttgtaacgg cgtggttaat gaggttacct ctacaagcaa 508141 tttactactg aaaagacaag agtttgaatg cgaggcacaa gggctttgga ttgcctggaa 508201 gggacatgtg tcccctttta taattttcat gcttttgtca gtcttatttg ctctaattag 508261 tacactgtta gtcaaatatg ttgctcctat ggctactggt tcaggaatct cagagattaa 508321 ggtatgggta tcaggttttg aatacaataa ggaatttttg ggtttcttaa cattagtcat 508381 taaaagtgtt gcccttcctt tggctatttc ttcgggatta agcgtaggta aagaagggcc 508441 ctcagttcat tatgcaacct gttgtgggta cttactcaca aaatggctac taagagatac 508501 tttgacgtat tcatcgcaat atgagtatat cacagcagct agtggagcag gtgttgcggt 508561 tgcttttggt gctcctattg gtggtgtcct ttttggtttg gaagagattg cttctgcgaa 508621 taggtttaac tcctctacct tatggaaatc ctattatgtc gccctagtcg caataactac 508681 tttgaagtac attgatccat ttaggaatgg cagagttatt ttattcaatg taacatatga 508741 tagagactgg aaggtacaag agattccgat ctttatagcc ttaggaatct ttggtggttt 508801 atatggaaaa tatattagta agtggaacat caactttatt cactttcgca aaatgtacct 508861 gtcctcatgg ccagttcaag aagtgctttt tttggcgacg cttactgctt tgatttctta 508921 cttcaatgag ttcttgaaat tagacatgac agaaagtatg ggtatattgt ttcatgaatg 508981 tgtcaagaac gataacacct caacttttag tcataggtta tgtcagttgg atgaaaatac 509041 gcacgctttt gagttcttaa aaatttttac ttccctatgc tttgccactg ttatcagggc 509101 cttgttggtg gtggtatcat atggcgccag agttcctgcc ggaatctttg ttccttcaat 509161 ggcggttggg gccacatttg gacgggcagt aagtctactg gtagagagat ttataagtgg 509221 cccttctgtt attactcctg gtgcctacgc cttcctggga gcagccgcta ccttgagcgg 509281 gataactaac ttgactttaa ctgtggtggt aataatgttc gagctaacag gcgccttcat 509341 gtatatcata ccccttatga ttgtagtggc aataacaagg ataattttaa gcacgtctgg 509401 tatttctggc ggtattgctg atcaaatgat catggttaat ggattcccat atttggaaga 509461 cgagcaagac gaggaagagg aggaaacctt agaaaaatac actgcagagc agctcatgtc 509521 ctccaaatta attactatta atgaaaccat ttacctttcc gagcttgaat ctttgttgta 509581 cgactcagcg tctgaatatt ctgtgcatgg ttttccaata actaaggatg aggataagtt 509641 tgagaaggaa aaaagatgta ttggctatgt tttaaaaagg cacttagcca gtaaaatcat 509701 gatgcaaagc gtaaatagca ccaaagctca aacgacactg gtatacttca ataagtctaa 509761 cgaagagttg ggacatcgtg aaaactgcat cggatttaag gatattatga atgaatctcc 509821 aatctcggtg aagaaggcgg tgccagtaac attgttattc cgtatgttta aagagctagg 509881 ttgtaagact atcatcgtag aggaaagtgg aattttaaag gggttggtca ctgctaaaga 509941 tattttgagg ttcaaaagaa ttaagtatcg agaagttcac ggtgcgaaat ttacatataa 510001 tgaagcactt gatagaagat gttggtcagt tatccatttc ataatcaaaa ggtttaccac 510061 taatcgaaat ggtaacgtta tatgattaga catttatgta atttttaagg cgctagtata 510121 gattattcaa aattatatga tacagacttt tatcaatttt tacttgttta agctccgtca 510181 ccctgttatt aaacgtgagc agagaaatgc cttttgaaaa cacactaaaa cacataagtt 510241 aatcttcgcg ccatttacca acctttttgt attggaggta aagtgctttg aaatattgtt 510301 tcccaggtgt gtcaaggaaa gcgttcaatt gattcaactc gttctgagat aatatatcaa 510361 aaatcgcatg aataccgggc tgcagactct tttttatgtt taaactgaac tgcgtcgtaa 510421 tagacaactg tatatatttc gttagaacca caagtacatt ttttctgatg gactgcttta 510481 tcaaacttat ctttgagctt aagttatttt tctgcccatt ttgagcgttt gatacattat 510541 aaggctcgca gtagttcgtt attagtctgg ctacggcgtc tgctgaattt gcacacaatg 510601 taccatcatg aattgctatt atttctagta tctggcaaag aacggagtta aacaaatggt 510661 gacgattgga aaatttaaac ctgtgaacta atagcatatg atctatcact tcgatgatgt 510721 taataaagcc ttcattgatt tcatccgttg actcatggtt tactataaaa gcgagagttt 510781 ttaaacagaa aggaagcagc atttcaatac agtattggct gaatagccat ggtttcgata 510841 ctaagaactc cttgatagca ttgaacagta gcaagtatga cttgtagcca aatttttcta 510901 tatcacaata ggtgtaggct tcaagtaaag ctatcacaaa taggtgatga ccaaggttat 510961 tgtctcttgc aatccttttt gacattatga taaaaactct cacaaatttt tcagcacaag 511021 gttggctaat ggtggaaaac gatttagcac tgttccagag caggcggtta aacgcatcag 511081 gaccttgttt aagactttct tccaagcaga accccaaggc agaatcgcac ttatctgtat 511141 gctcaatatt taagtactct gcaaaaatat actccaactt gttttctgta aggagtgaat 511201 gaaccaaaaa catttcctgt tcttctggcg catggtacac ttttttagaa tgatatcgaa 511261 gcataatttt ggaaaatata tccagaattc tcgatttatg cttagaaata tcgccttgtc 511321 cggtcgttat aatcttgtac aatgtagaca ttgatattct gaaaagggga attgtttcag 511381 attcaaaatt ttcagagtag ttttccaaaa ttttaacagc atagctaatt gccatacctt 511441 gtatatctct atgcttgtta tctggtttca aaaattttgc gatagtaaac ccggcgataa 511501 ttagtttgct atcaccattg gacaatgaca ttgactgttt aacgatatcg taaccagatt 511561 ctaagaactt ctcactcaca ggctcctttg cctgtgacag atgattagtc caaacttttt 511621 cgaaaataga tattttgtct tctatttcct ttttttcatc acctgtctct gaaatggcca 511681 tttcggggct cattattgtt ttctcacata attcgtagaa atttgtttca atgttgctct 511741 tgaaggtcgg gcttgacaat aaatgaagga ggcattctct agtagcggaa tcaaggcaaa 511801 atgattcgca tgttagattg ttaatgagag ccactctaac gtttttgttg atgcattgga 511861 taggaatttg aatcaaagct tctagagcga aggtttgatg gtatgatgaa gcaagcttgt 511921 ttattaaagc gtacgtgata tttgtctcct caaaaatgtc atcatttttt aataacgaag 511981 ataaatttgt cgagttcaat agtaatgaat caattaaaga agaaatttgt tctcttgtaa 512041 agttgttgtt tactaatgtt gcaaatttgg acacaacaga gtatgataag tttgactttc 512101 tttcttcgtc aaggatttca aagtgcctca tgaatttttt ttttgcatca gaaagatcga 512161 acgaaatata ttctctcaat ttgaagcaat aaaagaacag ttcttcaaca tcagccgatg 512221 tagtatcaaa aatattagaa gataacacgt aatcgatttt ttctagttcc tctgcaggga 512281 caatatcatc gtagacttcc attatatgat actttaggtc ccattgaaga ctgttattaa 512341 atgattccaa agtaaatact tgagataaaa taggctttac ctcatcgaga gttgcgcgcg 512401 atgcgccctc tgatagtccc tccaagcata tgcgtattaa atataaagga accctgttgg 512461 tggaatcgtg attgacttgg tcaagtaaag cttgcaatag atttttccat tgtaaagaag 512521 ataaagtgaa caattgcttc gttatagact tgacatatgc aggatgattt atcaaaaaat 512581 aggaatcggg tccttttctg gaacagtact catttatttt ggcaaaaaaa tctgataatt 512641 cccttgcgtt agcgtgtgat tggattatta aatcccaaat atgagaggaa aagagaggat 512701 cgttcaaatt ttcgagctga atcaattcaa gtaaccgaaa aatatgttta atagcaacct 512761 cgatatccaa tttaaggata attggtatta atgataacac tccagattca tcagtcgacg 512821 ctaacatttc aagcaataat gcttcaagga actcttgaga tacggttttc ttcgattccg 512881 ataaaagatt cagaaatctg cattctaaac taggtttctt ggcacctaaa attgtaaaga 512941 tgacttctag ttgagcaaaa ttgtcttttg ataagaaagt gacgaaagtg gcaaaataat 513001 aataagccat atcgtcggta atttcggacg cattctcttg gacaaacttt ttatttaatt 513061 tcatgtaatc tatgcgtggt tgtaaaagga actttcccat aaaatgagat agacgaatga 513121 aggattggtt tgaagatgca gaatttttgg tctgtgcgaa atatcttaaa cttggtagta 513181 gcatatgctt gcagtaacaa gtagcaattt tgttatccgt tgtagtaata ttgtcaacat 513241 gagttagatt gcaggcatct tgcaagtatg aaagcgcaaa gtcagtcgtc gggcacgaac 513301 ttaatccatt tatggcatgt tctaaaagtt gaaaagactc ttcaacagaa aaattgacaa 513361 tcaagtagtc attaatcgca aaaaatgctt ttataaacga aacgctacgt gtaagtaatt 513421 tgtctttagg ccaaaggaaa aatgttctta tcattacagg cacagtcttc aattttttga 513481 gtagtttttt tatcgaaatt ggatcattaa tagcatctaa taatctcgtg aaaattatcc 513541 aagtatgttc actggtctta aaatcatcca aatttccatt gttgagccta tcaatgagta 513601 aatctaagac gaaaatttct ttttttggaa agtaggtttc taatttatca aattttgaaa 513661 ctatctcggc aatttgatgg ggttttgtgc tcgtcgaacg tagtaatttc gacaaatctt 513721 gggcattgtc tgggatagat agttcttctg taagatcacc catattatca aaaagtgcag 513781 tatactctct gtttttccaa agataattga tggcaagcta aatcttagac agagatgttc 513841 ctatgctagt aaacaattct gtagttgtga ccaagtgccc tcttagcgat cattttgaga 513901 tgagctaagt gaaatttttc agatcgcgca cgacggagag gttttttagt tggatggaag 513961 tcaagccttg tacaaattgt agttgtatag aaaacattga acttacggtc ttgagttgag 514021 tcaataagcg tgagccagaa cgcaattatc agatatgaca atcgatgatt caaatcgatt 514081 acttatggac gtcgatcaat ttgatttttt ggacgacgga acggcgcaac ttagtaataa 514141 caagaccgat gaagaagaac aactatataa aagggaccca gtcagcgggg ctatcctggt 514201 ccctatgact gtaaatgatc aaccgattga aaaaaatggc gacaagatgc ctttaaagtt 514261 caagctgggg ccactttctt accaaaatat ggcattcata actgcaaaag ataaatataa 514321 gctttatcct gttagaattc ctagattaga taccagcaaa gagttttctg catacgtatc 514381 aggtttattt gaaatttacc gtgatttagg tgatgacaga gtgtttaatg taccaacgat 514441 tggagttgtt aattctaatt tcgcgaagga gcataatgca acagtaaatc tggccatgga 514501 ggcgattctg aatgaattgg aagtgtttat tggtagagtc aaggatcagg atggaagagt 514561 gaaccgattt tatgagttgg aagaatcttt aaccgtttta aactgtctga ggacaatgta 514621 cttcatatta gatggtcagg atgtagagga gaacagatca gagtttattg agtcattgct 514681 aaactggatt aatagatcag acggtgaacc agatgaagaa tatattgaac aagtgttttc 514741 agtgaaggat tctacagcag gtaaaaaagt gttcgaaaca caatatttct ggaagctttt 514801 gaatcagctt gttttaagag gcctgctctc ccaagctata ggttgcattg aaagatcaga 514861 tcttttacca tatttgagtg atacatgtgc cgtttcattt gatgcagtaa gtgactccat 514921 cgaactcctg aaacaatatc caaaagattc gtccagtaca tttagagaat ggaaaaattt 514981 ggtgctaaaa ttaagtcaag cctttggtag ttctgctact gatatttccg gtgaattacg 515041 ggattacatt gaagatttct tgttagtaat tggtggaaat caacgaaaaa ttctgcagta 515101 ttcaaggacg tggtatgagt ccttttgtgg gtttttatta tactatatcc cctcattaga 515161 actatcagca gaatatttac aaatgtcact ggaagctaac gtcgtagaca taacaaatga 515221 ttgggaacaa ccatgcgtcg acatcattag tggtaagata cactcaattt taccggtaat 515281 ggaatcttta gatagttgca cagcagcatt taccgctatg atttgtgaag caaaaggttt 515341 gatagagaat atttttgagg gtgaaaaaaa tagcgatgat tatagtaatg aagacaacga 515401 aatgcttgaa gatctattct cttataggaa tggtatggca tcttatatgc taaatagctt 515461 cgcttttgag ttgtgttcac tgggtgataa ggaactatgg cccgttgcca ttggattgat 515521 agccttatct gcaacaggga cgagaagtgc aaagaaaatg gtgattgcag aattacttcc 515581 acactaccca tttgttacga atgatgacat tgaatggatg ctaagtatat gtgtagaatg 515641 gagactacca gaaatagcga aggaaatata caccacgttg ggtaatcaaa tgttatcggc 515701 acacaacata attgaaagta tcgcaaattt tagtagggcg ggcaaatatg aactggtaaa 515761 gtcatattcg tggctattat ttgaagcttc gtgcatggag ggccagaagt tggacgaccc 515821 tgtgttgaat gccattgtga gcaaaaactc tcctgcagag gatgacgtta taataccaca 515881 agacatttta gattgtgtag tgacgaattc tatgcgtcaa actttagcgc catatgctgt 515941 tctgtcacaa ttctatgagc tgagggacag agaagattgg ggccaagcgc tgcgcctatt 516001 gcttttgctg attgaattcc cttatttacc aaaacattac ttggttttgc ttgtggcgaa 516061 attcctgtac ccaattttcc ttttagatga taagaagcta atggatgaag attcagtggc 516121 gacagtcatt gaagttatag aaactaaatg ggatgacgct gatgaaaaaa gttcaaactt 516181 atatgaaacc attattgaag cagataaaag cttacctagt agcatggcaa cacttttgaa 516241 aaatttaaga aagaaactaa atttcaaatt atgtcaagcg ttcatgtaaa tcagtatagt 516301 aatgtccttc ggatggtata ttaggatata tgacgaaaat aagtaaattt aaacaacaat 516361 atatatttat attgatctat ttttctatca cgtaagttga catttgtatt atacattaca 516421 tcacaattag taatggaaag tgtttggaaa aaaaagaaga ttattttgcc tttcttttga 516481 aaaagctttc caatgttcct tgctttttta accttttatt cgatgacggc gtttcttgct 516541 tttttgaaga cgacaatgcc ctttttacca cgggtgatgg cttgcgtggt ggtgttgaag 516601 ttgcgggtct ctttgtcaca atatatccat cctcatcaat aaaagaggag ggctcttctt 516661 cagatttagg ttcctttgaa tgttctgttt cagaaggctt tgtttgctgt attttaggta 516721 catccataag tgaatcttct gctgtcgttt ccaacaagtc ttctaaatca tcgttgtttt 516781 tgtccttatc gttgctgtca gtttctttag gtgagttggg cttggaccct ccatttactt 516841 cctctgtatc taagtcatct tcgacaaaaa gattatttaa ctctttcatt tgagcttctc 516901 tttcagggtt ctgtttattt attttttgca agttctcctc tttcctttta cgtaactcat 516961 tttgtctaga ggtttccttg tcatctctat cctttttcat cttagccagc agtgcagtag 517021 acctgagacc catgtcttta gatttggatt tccttccggt tgtttcttct ggcgtggtct 517081 ttgatcttgc tgtaggcctt accaaaggtt tagatttctc ttctaacgtc ttagtcctct 517141 ctataatttt cgatgattca gaaactttaa gttcgtatga atttttaatg gttaaacaat 517201 ccttttgatc gataatgtcg taatatggta tgaagctgtc catgggattg aaggcataga 517261 tgaaacaatc aattattgaa tcttgctgtg gaatgttgga aagatcatga ataattttaa 517321 tagtttgatc tttgtagcag catatcacta cgcagttgta tttggcattg gtggtctgtt 517381 tgtaatagtc aaacattaat ttcttggcca tggatgggcc gatcttcaag tggtgaatta 517441 gatccgtaaa aaggacgggc tttacctcag tgaagagctt ctcattgata aaatatgacg 517501 ccttttgatc cattaattac cgattgagtt aactaaagcc tatttctggt tgttagttaa 517561 tgtgaaatat tatttcgagc tgatctgatt gcgatgtaac gaacttctgc gtacttttca 517621 aaattaagag tttcgcgtgt ttaactcata cgcgtttact acttccgtcg gaaagttaca 517681 ccgtagtgga aaatagacct attcgttagt ataaccttat taaggtactt ccattaatga 517741 agtgttctat attgaggcat actgatcgag aattttcata aggtgaaacg ataaaaatat 517801 aaaaattaag cttagcgccg ctcggtttcg atccgaggac atcagggtta tgagccctgc 517861 gcgcttccac tgcgccacgg cgcttaactt ttatgaatat tttagactta ataaagattc 517921 atattgtaaa attaaaaaca acttgcacac tgagctgtgt tagaatgaaa tcctactata 517981 atccatagta gtattcatgt cactagcaca ttacaaaata tgccatagga agatgacgta 518041 aagattgaga actagtcatc agatataata gaagctgaaa agcaagaatt gataatatcg 518101 gacgctatcc tacaatagca gcgcagttgc ataatttgtt atgtgtcgtc tttattgtgt 518161 gtaaagcttt atacaccttt acctttgtgt agaagacaaa gacattgttg ttatcactat 518221 gtccacattc gctacgagga tattttcaac atatctagtt gaaatacaaa tctcaagcca 518281 ctataaaaac tgcggaatca aacaaatgta caatacatta tcctactaga gactaatttc 518341 tcaaggtttg caatcccatc tcttttcatg aggtatattg cggcacagaa tggttgtacg 518401 accattgctc aacgtttccg ctcatagatc gattcaaata agattataga catgtggcga 518461 ttcaatgcca atccttatcc cgaaattacg gatgtattca gccaactttg cctatctaca 518521 ttattctgtc aactagaggc taaagacacg aatttcttgg cattttttgt ttgaaaactt 518581 gaaatggaag aaagacagaa agtaatttta tgtaatctat tatatttaag tagttctaaa 518641 aaaaaggaga aatcgacgcc agatttccca ccttgagtag agtatcatac tatataatat 518701 caatgtacgg ttcacgcacc cagttggctt agtctgttga ggggatgagt aattgttata 518761 tattaaccaa aaagggaatc atcttcgttg aaatcttttt tgaaaaacca tttaaaaata 518821 acaatactag aatatatgat aagaccaccg atcatgcaca tgatacaact caaatggcca 518881 atcaattggc aatgatagaa aacaacaggg agtgctatac cgcttgtcac cagcattcct 518941 gtaaggaagt gagccagatc ttggccagtg tttgatgaat cggacatgaa gtcagatgtg 519001 tgatatttat ttcctgcatt gaaaattgtg tttggtattg gggcaagcaa aaagatcaaa 519061 atatcgaata gtgggtagta attatggaat aatgcgcagc ttagtatgac caaaaggaat 519121 cccaatgcga ggaatcctga cagagaaata atctttgtca atggtgacac tttgaattcc 519181 atcataaccg tctgggattt tatgtattaa gattctttgc cttttagatt tgataaatat 519241 gcgccgatat tagacgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgattc 519301 cccttttcta gtttttctcc tactcttttt ttctcagttt ttcgtaaagt ggagtgaaag 519361 cccatctaag aaaaaggcat aataaaatgt aataattttg aggagtacat ttgggtatag 519421 aacaggatca aactaattac aagagataca tggctttccc gcttaatgcg aggaaacagt 519481 acttatataa acgatatatg tttggggcgt gtatattatg tatataaatg ttcttaaaaa 519541 ataaagaaac aaaaatactg gttagttatt attatgtttt ttgtcattct ttctagttta 519601 acattgtggt agtaatttat taacaggaat ttgcttttta ctgcttagtt tcaccagatt 519661 cggcattgtt gccgttgttg ttgttgttgt tgttagagtc gttcttgtat aattgttcaa 519721 acaatttcat cgaggaagtt tgcaattctt cggtcttggt ctttaactcc tcagcgttaa 519781 cctcttcgcc accttgtact ctagcaacca actccttcaa ggaagtgatt tgatccctaa 519841 ccttttgggc ttcagccttg tcaaccttac cttcaaattc tttcaaggag ttttcagtat 519901 cgttggccaa ttggtcagcc ttgttggcag tttcgatggc ttgttttcta gcttcatctt 519961 gagacttgaa tttttcagcg tcgttaacca tttgttcaat ttcgttttcg gacaaaccag 520021 aagaaccggc aacagtaata gaagaatctt tgtttgtagc tttgtctcta gcagaaacgt 520081 taataatacc atcggcatcg atgtcaaaag tgacttcgat ttgtgggaca ccctttggag 520141 caggtgggat accggctaaa gtgaagttac caatcaattt gttgtctcta accaattctc 520201 tttcaccttg gaaaactctg atttcaacag aagtttgacc agcagcggca gtggagaaga 520261 tttgagattt ctttgttgga atagtagtgt ttcttggaat caatcttgtg aaaacaccac 520321 ctaaagtttc gatacctaga gacaatgggg taacatctaa taataagacg tcagtaacct 520381 caccggacaa gacagcacct tgcacagcag caccaatggc aacagcttca tctgggttga 520441 cggccttaga tgggtcctta ccaaacaaag atttaacggt ttcgacaacc ttaggcattc 520501 tggacatacc accgaccaat aagacttcag atatgtctga agtagacaaa ccggcgtctt 520561 tcaaagcctt cttgactggg tcgacagttc tcttaactag tggggctgtc aaagtctcga 520621 attgagccct ggagaacttc atgttgatat gctttggacc tgaggcatca gcagtgataa 520681 atggcaggtt gatttcagtg gaaacggtag aagatagctc aatcttagcc ttttcagcag 520741 cttctctaat tctttggata gccatacggt cattttccaa atcaatacca gtttcggtct 520801 tgaaacgaga aacaatctct ctcaacaaat agatgtcgaa atcttcacca cccaaatgag 520861 tgtcaccgtt agtggactta acttcaaaaa caccgttgtc aatatctaag atggagatat 520921 cgaaagtacc accacccaaa tcgaaaacgg caacaacttt agagtcggat ttttccaaac 520981 cgtaagctaa ggcagcggcg gttggttcat tgacgacacg taaaacgttc aaaccaacaa 521041 tttggcctgc gtctttagta gcttgtcttt gagagtcgtt gaaataagct gggacagtga 521101 caacagcatt cttaactggc ttacccaagt aggcctcagc tgtttccttc atcttgttca 521161 agacgaaccc accgatttgg gctggtgagt aagtttgacc tctggcctca acccaagcat 521221 ccccgttgga gtgcttgacg atcttgtatg gaacttgctt gatatctctt tgcacttcag 521281 cgtcttcgaa acgacgacca atcaaacgct tggtagcaaa tagggtgttt tctgggttca 521341 ctacggcttg acgcttggct ggaataccaa ccaaacgttc tccctcttta gtgaaagcta 521401 ctacagaagg agtagttctg gaaccttcgg cgttttcaat aatttttgga actttacctt 521461 ccataatggc aaccgcagag ttggtggtac ccaaatcgat accgatgacg gaaccttgaa 521521 ccttggttga ctgcaaacgt gtggcaatac ggaaagagct agacaagctt gacctgttta 521581 gtatgttttt agcagcaagc atcttggtgc gtataatatg agatttgtgt agtcttaatt 521641 atattaaatg ggtcgtaaat acaaaagttg tcactctggc aaaggttggt gagcagcggg 521701 gcgtcgatat gtacagcagg cagaggagga cagcaacgta tggagttttc aaacgtggaa 521761 caaagaaccc aaaagttccc aagcgtcgag ccggcgttgg atcgttcgtt tttatacacc 521821 gcaccgtaag cggtcaccgg aaaaagaggc agggggcggt ggaaccgggc cgaagcccat 521881 ggaaaagctc tgccgttgtg ggtgatatac aattattcag cgcatctaag gcactagctt 521941 tagcacattg taccattgcg atgatgcgga agagtttaat ataagcagat gttagttgcg 522001 gtagttggta tcatgacagt gagctgaact acgtagcgtc gtgatttatg agtggcacag 522061 ctaatagtag gaggaaggag gttttgcgcg tgcctgtgat agatttgaat agagtttcag 522121 atgaagagca gctgttgccg gtggtgaggg caattttgct acagcatgac acctttctgt 522181 taaaaaatta tgctaacaag gctgttctag atgcactact agcggggctc acgacaaagg 522241 acctgcctga cacgagtcaa ggttttgatg cgaactttac gggtacatta ccgctagaag 522301 atgatgtttg gctggagcag tacatatttg acactgatcc tcaattacgc ttcgatcgga 522361 agtgcaggaa tgagtcactg tgctccatat atagtaggct gttcaaactg ggtctgtttt 522421 tcgcccaact gtgtgtgaaa agtgtggttt ctagcgcaga attgcaagac tgtatcagca 522481 cctctcatta tgcgactaag ctgacccgtt atttcaatga taatggtagt acacacgatg 522541 gtgcagatgc aggtgctacc gtgctgccca ctggcgacga tttccagtac ctgtttgaaa 522601 gggactatgt tacttttctt ccgacgggcg tgttgaccat cttcccctgt gccaaggcta 522661 taaggtacaa gccatcgact atggcgacga cggacaattc ttgggtgagt attgatgaac 522721 ccgattgtct tctgttccac acggggaccc tccttgcgcg ctggtctcaa ggtatgcaca 522781 ctacctcacc actccagata gatcctcgtg cgaacattgt ttcgttgacc atctggcctc 522841 cacttactac gccaatctcg agtaaaggag agggtacgat tgccaatcat ttgttggagc 522901 aacaaattaa ggctttccca aaagtcgctc agcaatacta cccacgggag cttagtattc 522961 taagactcca agacgcaatg aagtttgtta aggagttgtt tactgtttgc gagactgtat 523021 tgtctttaaa cgctctttcc agatccacgg gcgtcccacc agagctgcac gttttgttac 523081 cccagatatc cagcatgatg aaaaggaaaa tagtgcagga tgatattttg aagttattga 523141 ccatttggtc tgatgcatac gtagtggaac tgaactctag aggggagctg accatgaatc 523201 tacccaaaag agacaatcta acaacgttga ccaataagtc taggactttg gcattcgtgg 523261 aaagggcaga gtcgtggtac caacaagtga tagcttccaa ggatgagatt atgactgatg 523321 tacccgcttt caaaataaat aaaagaaggt ccagctctaa ttctaaaaca gtcttgagca 523381 gtaaagtgca aacgaagagc tctaatgcta atgccttgaa taactcaaga tatttggcga 523441 atagtaagga aaatttcatg tacaaagaga agatgcctga ttcgcaagca aaccttatgg 523501 acagactgcg tgaaagagag agacgttcgg ccgcattgct ttctcaaagg caaaaacgtt 523561 accagcagtt tctagcgatg aaaatgactc aggtatttga tattcttttt tcgctgacca 523621 ggggccagcc ttatacagag acatatctaa gctcgctaat cgtagatagt ttacaagata 523681 gtaataatcc tatcggtaca aaagaagcaa gtgaaatttt agctgggcta caaggtatcc 523741 taccaatgga catatctgtt catcaagtgg atggtgggtt aaaagtttat agatggaaca 523801 gtttggataa aaacagattt tctaagctgt tgcaaatcca caaatcaaaa caacaagatt 523861 gaagaatatt tttagatata aggtagaata cgtacattta cggtaaaaaa aaaaaaaaaa 523921 gaaaaaaaat tgatcttgat acatacgttg gtattttact ttgaagactg tgcattgtgt 523981 atgtacgaaa agaaagggaa ataaaaaata acgacaactg caggactcga acctgcgcgg 524041 gcaaagccca aaagatttct aatctttcgc cttaaccact cggccaagtt gcctttaatc 524101 tcttgagttt gtttaaggac aacactgtcc acctggcatg ggaatattac cattattcca 524161 gattcgggct tgttattagg actttttacc agcttgattt accggtcatt acttatccta 524221 cacatcatac atcacaacta cacttggtga agaaatcaca gagccttgga tttgtaacaa 524281 ttatatgttt acgcaattta tcttgggaaa gcagggcctc atttgtggac atagcacggt 524341 ctgtcaccct cgtcgtgcaa aaaatatttt gacttctact ctttttgaag tttcgttgat 524401 cgggtccctt ccaaggaaaa gtcgaatgct gtcactgcgc atataaaggc gagaacgata 524461 gtgactgtga tattaagtta ttgtcatcat ataagtaatt ttttctctga tatctgtagc 524521 cctagttttt aatattttcg taaaatgctc aaaaaaattt ctgtttaaat tcttctgggg 524581 tatatacaca tgttcccgtc agctaaatta aaaagaagaa ggaaccgaaa gaaggcaaat 524641 tataaagtaa tcatcctcgg catattgagg ggaaaatatc cgtcaaaaaa aaaagttctg 524701 cacgtcgtca taagtgacta tggtatcaaa caccaattaa cacgaacgta gcgataatga 524761 aggcaacttc gtagctgaaa cagaacgaag ttagttagga tgaataatta tgattatgat 524821 tattataata ttatataaaa tgtataaata agatttctag atcaaaaaaa catcgcgtat 524881 tttgtaagct atagaaatct aaaatatcta atcagatctt ggagcttcct tgaaggagat 524941 ggcagcttct tcacccatgg cagaaatgat agtgaccatc aaatccttac cttcatcgaa 525001 agcagcttgc atgctgtcac ccaattcacc ttctggtgcc ttgacatcgt ctttggtttc 525061 accgtccatg gtcatcaagg acaagtagcc atcatcaata tccaacaatt ggtattcgct 525121 tctcttgaca aatggaactt ccaagttgtg agtggatgga gacaaatctt ccaacttctt 525181 accagtgaag atatcaaggg taaccaaatg gaccttggcg tgaccgtgct taccggtctt 525241 ggaagtggac atgtcgacaa tcttacatgg tctacctttg atgacaacga aaccattctt 525301 tctcaaggca gaacattgca ttgggtaggt ggcggaggca ccagcgtcag cattttcaaa 525361 ggtgtgttct tcgtcagaca tgttttagtg tgtgaatgaa ataggtgtat gttttctttt 525421 tgctagacaa taattaggaa caaggtaagg gaactaaagt gtagaataag attaaaaaag 525481 aagaacaagt tgaaaaggca agttgaaatt tcaagaaaaa agtcaattga agtacagtaa 525541 attgacctga atatatctga gttccgacaa caatgagttt accaaagaga acaatggaat 525601 aggaaacttt gaacgaagaa aggaaagcag gaaaggaaaa aatttttagg ctcgagaaca 525661 atagggcgaa aaaacaggca acgaacgaac aatggaaaaa cgaaaaaaaa aaaaaaaaac 525721 acagaaaaga atgcagaaag atgtcaactg aaaaaaaaaa aggtgaacac aggaaaaaaa 525781 ataaaaaaaa aaaaaaaaaa aggaggacga aacaaaaaag tgaaaaaaaa tgaaaatttt 525841 tttggaaaac caagaaatga attatatttc cgtgtgagac gacatcgtcg aatatgattc 525901 agggtaacag tattgatgta atcaatttcc tacctgaatc taaaattccc gggagcaaga 525961 tcaagatgtt ttcaccgatc tttccggtct ctttggccgg ggtttacgga cgatggcaga 526021 agaccaaagc gccagttcat ttggcgagcg ttggttggtg gatcaagccc acgcgtaggc 526081 aatcctcgag cagatccgcc aggcgtgtat atatagcgtg gatggccagg caactttagt 526141 gctgacacat acaggcatat atatatgtgt gcgacgacac atgatcatat ggcatgcatg 526201 tgctctgtat gtatataaaa ctcttgtttt cttcttttct ctaaatattc tttccttata 526261 cattaggacc tttgcagcat aaattactat acttctatag acacacaaac acaaatacac 526321 acactaaatt aataatgact gaattcaagg ccggttctgc taagaaaggt gctacacttt 526381 tcaagactag atgtctacaa tgccacaccg tggaaaaggg tggcccacat aaggttggtc 526441 caaacttgca tggtatcttt ggcagacact ctggtcaagc tgaagggtat tcgtacacag 526501 atgccaatat caagaaaaac gtgttgtggg acgaaaataa catgtcagag tacttgacta 526561 acccaaagaa atatattcct ggtaccaaga tggcctttgg tgggttgaag aaggaaaaag 526621 acagaaacga cttaattacc tacttgaaaa aagcctgtga gtaaacaggc cccttttcct 526681 ttgtcgatat catgtaatta gttatgtcac gcttacattc acgccctcct cccacatccg 526741 ctctaaccga aaaggaagga gttagacaac ctgaagtcta ggtccctatt tatttttttt 526801 aatagttatg ttagtattaa gaacgttatt tatatttcaa atttttcttt tttttctgta 526861 caaacgcgtg tacgcatgta acattatact gaaaaccttg cttgagaagg ttttgggacg 526921 ctcgaaggct ttaatttgca agcttcgcag tttacactct catcgtcgct ctcatcatcg 526981 cttccgttgt tgttttcctt agtagcgtct gcttccagag agtatttatc tcttattacc 527041 tctaaaggtt ctgcttgatt tctgactttg ttcgcctcat gtgcatattt ttcttggttc 527101 ttttgggaca aaatatgcgt aaaggacttt tgttgttccc tcacattcca gtttagttgt 527161 cgactgatac tgttaataaa ctcatcgggc gaggcttcca cggttggaaa agcatatggg 527221 ctggcgcata tggttataaa atcacctttt tgcaattcaa ttctatcttt cccatcaaaa 527281 gccgcccatg ctggagccct tgacttcatc gagactttca cttttaaatt tatactttct 527341 ggtaagatga tgggtctgaa actcaatgca tgtggacaaa tgggtgttaa agcgattgca 527401 ttgacggttg ggcataccaa tgacccacct gcactcaaag aataggccgt ggacccagtc 527461 ggagtagcag caatcagtcc gtccgcctgc gcaacggtca ttaatgagcc gtcaccatac 527521 aattctaaca tggatagaaa aggacttgga ccacgatcga tggtcacttc gttcaaaatg 527581 tggtgtgtgc ttagtttttc caccacacat attttcttcc ccgtgtttgg gtctacttca 527641 gggcggtgtc tacgataaat tgtgcactcc aacctcaacc gtaaatttgt cttgatttta 527701 tgattcataa tccgaggtaa atcctccctg aaatgttcaa acttaaaatt tgttaaaaat 527761 cctagagacc ctaatgaaaa cgacataacg ggtggtacat gtctctgaaa aatggaactt 527821 acaaaaagaa cagtaccgtc gccacccaaa gtcactacca aatcgaagaa aacatcatgt 527881 tccctgatga aatcctttgt ccaatacttg atccttgatt ctctacattt actatcttca 527941 cataactcgc cagcggcaaa ttttttgctg tttttcaatt cggaatccac ataaacagtc 528001 acacgtggaa aatgtaccaa aacccattct accaactctc ttgttaagaa atacagtgag 528061 acatcgttga gtttcgtaac aatcatcaaa ttttccacat ccagttccac tttggtatta 528121 gatatatctt tactcaacat tcttacacca tacgccgtgg aggcatactg aaagtgtgta 528181 ttactactct tagaacttcc tcttgttccg ttaatgctcg taccaccgcc actgtttgca 528241 ttgccgttca cgagagatga atctttattc aacagggagc ttctgcgcga gctgctttca 528301 cttgatattt tcctcaacat ttctttggcg ttgtcgatat cctgagttct atcaatttgc 528361 tcattgttca tcatggcctt cttcatcaag ttattattgt tgttatgatg atcatttcga 528421 ccatcttcct catttaccca tttatctacg ccattattca tgtcattctc cttcatctca 528481 agagctttta ctctacttat ttagggagcc tattgtattt ttttttggct tacgatcacg 528541 atgtcaatga tcatttgccc tattatacct ttttctccgt tctctttgcg tagtgcggtg 528601 aaataatttc aggatgcatg aaagagcaaa taaaagtgac acaccgttat atcgcaaggc 528661 gcaccacatc agtaatcaga tacctgtgca ttcaaaatga gtagaaatgt agataaggcc 528721 aactcagttc tggtacgatt tcaagagcag caagcagagt cggcaggtgg atacaaggat 528781 tattcacgtt accagaggcc caggaacgtg tctaaggtaa aatccataaa agaggccaac 528841 gaatggaagc gacaagtaag taaagagata aaacaaaaaa gcacaagaat atatgatccg 528901 tctttaaatg aaatgcagat tgcggaactt aacgacgaac ttaataatct tttcaaagaa 528961 tggaagagat ggcagtggca cattgaccat acacttatgg aaaaaaaaac caagaggaaa 529021 aggttagaag acagtcatgt gctgatgaat tcaggaaagc tgataaatgg taagagatat 529081 tttggaagag ccctggaatt gcctgaagta aaagaatggc tcaagcagtc tcaaaggcag 529141 aatgatgggg gttctataaa caccaaatgc ataccgaagg atagaaatga tttttattac 529201 catggcaaag tcacagccgc cttaaccgaa tttgaggcta actggacatc cattttgaaa 529261 gcacattata atgtgcctgt gaatgaagat gaagaagaaa tgtcaaggca gacacaagaa 529321 atccatgtac caactctggc agatatggag cattggttag tgcaaagaag aaaaaagaaa 529381 ctaatggatg aacttaacct ttagctatgg aaaattattc aaacatttag aagaggcact 529441 atttcgaatg accatcacaa gcattataat cttcaaacat gtccgagctg cagatatgaa 529501 gtaaaatagt gatcgggact catttttttt tcttctatga tatcatattg tcccgttcgt 529561 tattaaatgt aattcttcca ccgtactagt tatcgaaggc aagatctcct ttttacgctt 529621 aggtagatta catagatttc ataatgtaca ccaatacaaa tgtatcttat acactcgtca 529681 aatcttatat gaatcatgca ggagtagctc tcgttttctt tttacgagct acttgaaaaa 529741 aaaaaactag cgaaaatcct ttgcttagaa atccagattt aaaacaaaac cgccgaaaag 529801 ggaaagattt tatgatagga aataccttaa taattctata tcatcccgag tcttaggaaa 529861 atgattagat ctgtgagaag ggttttcatt tacgtctcaa tattcgtatt gataatagtt 529921 ttgaaaagaa cattaagtgg cacagatcaa acgtcaatga aacaaccagt ggtggtcatt 529981 ggctctggtt tggcaggctt aaccacaagt aatcgtctca ttagtaaata cagaattcct 530041 gttgtgcttt tggataaggc ggcttctatt ggtgggaatt ctataaaggc ttctagtggt 530101 attaatggtg ctcacacaga cactcaacaa aatttaaagg taatggacac tcccgaattg 530161 tttttgaaag atactttgca ttcggctaaa ggcagagggg ttccatcact gatggataag 530221 ttgactaagg aatccaagag tgctatcagg tggttgcaaa cagaattcga tttgaaatta 530281 gacctccttg cgcaattggg cggtcactct gttccaagga cccatagatc ttctggcaaa 530341 ttaccaccag gttttgaaat cgtgcaagcg ttatcaaaaa aactaaagga tatctcttcc 530401 aaagattcca atctcgtgca gattatgcta aacagtgaag tagtggatat cgagcttgat 530461 aatcaaggtc atgttactgg tgtagtatat atggacgaga acggaaaccg taaaatcatg 530521 aagtcacacc atgtcgtgtt ttgctcaggt ggatttggtt actctaagga aatgttgaaa 530581 gagtactcac caaatttgat tcacttgcca actactaatg gcaaacagac tacaggtgat 530641 ggtcaaaaaa tcctttcaaa gttgggtgcc gaattgattg atatggatca agtgcaggta 530701 caccctaccg gcttcattga tccaaatgac cgtgaaaata actggaagtt tttggctgca 530761 gaggcattga ggggtttagg cggcatctta ttgcatccca ccactggaag aaggtttaca 530821 aatgaattga gcaccagaga tacagtaacc atggaaatac agtctaaatg tccgaaaaat 530881 gataatagag cacttttggt aatgagcgac aaagtctacg agaactatac gaataacata 530941 aacttttata tgtccaaaaa cttaatcaaa aaagtgtcaa tcaacgatct gatccgacaa 531001 tatgacctac aaactacagc ttctgaactg gtaactgaac tgaagagcta ttccgatgtt 531061 aatactaagg atacgtttga taggccattg attatcaatg cctttgataa agatatttcg 531121 actgaatcaa ctgtttatgt tggggaagtt acaccagttg ttcatttcac aatgggtggt 531181 gtgaaaatta atgagaaatc tcaggtaatt aagaaaaatt cggaaagcgt tctatctaat 531241 gggatatttg ctgctggtga agtttcgggt ggtgttcatg gagccaacag attgggtgga 531301 tctagtttgt tagagtgtgt tgtctttgga aagacagctg cggataacat agcaaaattg 531361 tactgagaat ttatagggaa ataaaagata tttttgcaac gtactttaca tttcaataat 531421 taatgcgaca tgataggata tactgtttgc tatttctttc cgtaacgata tacgattttt 531481 tcttttcttt ggagttccaa atgaagaata tatcttgttg ggaaaagcta tagtattagg 531541 tttacagaat atggtagagg tttctccccg acgatatagg aatctacaag agagagcatg 531601 attctacacg ataatactgc aatttcttct ttgcgttgaa gtgtcaccat tgcctatcct 531661 tttacattat caatgtcaat gttccctctt ctaacaaact gaatgacttt tctacacgat 531721 tcatattatc ttcttgcgca gtaaattatg ttaacgtaat agtagggtct cttgtgcttc 531781 attattttgt aactgtacac ataattgaca cgtttaacaa ttagtgagcg caagtggttt 531841 agtggtaaaa tccaacgttg ccatcgttgg gcccccggtt cgattccggg cttgcgcagt 531901 ttcttttctt tttttctgga aaataagaaa acttatttat ggaagcaaaa atggaataaa 531961 ggattgggac gaagttagtg aaaaaaaact gaaatagtcc tagagtaact ccgaagtgtc 532021 tttgtataag ctattatcta gaaatcacga gaggggaaga aatgtatcgc agtagaaacc 532081 gaccaaaaag aggtggagaa aatgaagtta agggaccaaa ttctgccttg actcaatttt 532141 taagagaaga agggatcagt gctgaaaata tcaaacaaaa atggtaccag cgacagtcga 532201 agaagcaaga agatgcaaca gacgaaaaaa aaggtaaagc ggaggatgat agctttactg 532261 ccgagatatc tcgagtagtt gaagatgaag aaattgatga aattggaaca ggtagtggta 532321 ccgagacaga aagagctcag gtttcctacg atgccaggat gaaattagtc cctgctgata 532381 gtgatgaaga agaatatgaa actagccaca tttctgacac gccagtcagt ttaagttcgg 532441 ctaatgaccg ggaatcattg actaaaaaaa ggcaaaatac tgcaaaaatt atccaaaatc 532501 gtcgcagaaa gcgtaaaaga gcagctgacc tattggatag acgcgtcaac aaagtatcca 532561 gcttacaaag tctttgtatt acgaaaatta gtgaaaatat atccaagtgg caaaaagagg 532621 ctgatgaatc atcaaagttg gtatttaaca aattgagaga tgtccttggt ggcgtatcaa 532681 ccgctaattt gaataatttg gcaaaagcac tatcgaagaa tagggccctg aatgatcata 532741 ctctgcaact tttcttgaag acagatctaa aaaggttaac tttcagcgat tgttctaaaa 532801 tttcatttga tggttacaaa acgctagcca ttttttcgcc acacctaacc gaattatccc 532861 tacaaatgtg tgggcagttg aaccatgaat cattgcttta cattgctgaa aagcttccga 532921 acttgaaatc actgaattta gatggaccat ttctgatcaa cgaggacaca tgggagaagt 532981 tctttgtaat aatgaaaggt agattagaag agttccacat ttctaatacg caccgcttca 533041 ccgacaaatc attatctaat ttattgatca actgcggttc taccttggta tccttagggt 533101 tatccagact agattctata tcaaattacg ctttattacc gcagtaccta gtcaacgacg 533161 aatttcacag tctctgtatt gaatatccat tcaatgaaga ggatgttaac gatgagatca 533221 tcataaatct gctaggtcaa atcgggcgca cgttacgtaa attggttttg aatggctgta 533281 ttgacttgac agattcaatg ataatcaatg gtctgactgc attcattcct gagaaatgtc 533341 cattggaggt attgagcttg gaagaatcag atcagatcac tacagattca ctgtcgtact 533401 ttttcagcaa agtagaactg aataatttga ttgaatgcag ctttagaaga tgtctacaat 533461 tgggcgatat ggcaattata gagctattgc ttaacggagc aagagatagt ctgagaagct 533521 taaatctcaa ttcattaaaa gagctaacta aggaggcatt tgtggcgtta gcctgtccta 533581 atctgacgta tcttgatctt ggttttgtac gttgtgttga tgactcggtg attcaaatgt 533641 tgggtgagca aaatccgaat ttaactgtaa ttgatgtttt cggagacaat ttggttactg 533701 aaaaggccac aatgaggcct ggacttacgt tgatagggag acagagtgac agtatataat 533761 aaaataaaga catataaaac gtgtattaga tagaaaacgg aaaattgact aatgttttta 533821 ttcctattat actcagatcg tcaaatgttg cctttatttt ctattgaagg gattttatgg 533881 catctcgcga ataataaaca aacaataata gtaaaaaaaa aagtgtaaac ttatgtattc 533941 agcgcagata aaaggaaaaa aacgagaagt ttgacgtaaa gaaaaaagtt cgaaaacttt 534001 tgtagcagtt gaaagttttg tatgctatgt caattaggcc tctcacgtta aacggtttag 534061 atgagccaga aacctctttt gaagaactga atacaactct acctcgcttt caatcccatg 534121 aaacattaac tttggaagaa aacgtgccac cattgagtac atcaacttat ataccgcctc 534181 catcctcggt aggtacttct gacactggca cggtattttc caatagtacc agcgcgtttt 534241 ggtctaataa gcaagcagac gatgatcagg acatggaggt agaccaggat gatgaatttc 534301 taaatgactt ccaggaattc caaaataaaa aggatgattt tgacgatgct attaaaacaa 534361 attttcattt gagaaatgga tgtcgaactg gccctttcaa aaacgacatt ttcgcagaag 534421 agtttgatag aaaactgagt ttggaagata aaccaaggct aaagcaacct agatcaatga 534481 tggaattgaa accaaaaaga aaactatcaa atagcgtcac ttcaagaaac ttaaggtctg 534541 gtaattctgt aagatttaag aaatctatgc ctaacttagc tttagttaat ccagctatca 534601 gagaagaaga agaggacgaa gaacgagaaa gagaagatca acgagagttt aattacaaga 534661 ttgataacga tacgcaggac acaattttgg cgaaattcag ttcagatgat gaaggtgact 534721 ttctgacagg atttgaagaa ttagagggtg aagcaattga tgaaacgatt tcttcgaacg 534781 ataaagaaag tgccgaccat ccgcgtttct taaagaagtc atcctcatct ttgccattaa 534841 aaatatcacc tgcacaatat gatatagtaa agcatgacga attattaact ccaggtcttc 534901 ataggcgaca acgagattgg aatacccagc aggaactgga ctcttttaaa gaaaaacgat 534961 cagtaagaca ctgttctaat caaaatgtac aactcaatgg tccagctaaa atcaaaacaa 535021 taaaacagca aattgatcat aatactccaa tgaagaaagg ttctatgata tataacccga 535081 aaactatgaa gtgggaagga aatgaaaacg tcttaagcaa atttagtgat gtagacacgg 535141 caaacaggaa agctttattg ataaaaaaca agctacaacg agatgcagat tctaagaagc 535201 aaaaatattc tgatctacag catgcaagag ccacttcgag aaatcaaaag gtcatcggga 535261 acatgatttt agatgaacaa aatttaagat gggttagtgt ttcagaggaa gaagcagacc 535321 cttttgcagg cattcctgag ataaacttac caccagttgg caaaagtatg aaaaaacgta 535381 gctcctcacc atttttgcgt tccaaaagcc aagttaatac gccatttgtt tcaaatgaca 535441 atgatggcgt ttatcaaagt acggctgctc aagcaagact ccgtaaatac cattcaatga 535501 ggacacttaa cggtacaaca gaaactccag aaataagctc tactttccat ttgagttcaa 535561 gagcattgga aaaattttac cacgaggaga acaggtggtg taaaaagtta gcctcatggt 535621 ttataccccg agatgagacc attatcagtg ttgatgagga aacaatcatg gatgaaagta 535681 cggtcaatag caagagaaaa tcctatatgt atgaaatcag gaacatggta atcaattcga 535741 caaaagatta gccctttagc cttcttataa ctgtttcttt accgttatct tgagtacatt 535801 catttctctt acattccaaa attagataga accttgaatc gtgtcaactt ttcgccgaca 535861 tttcgcgtct gacagaaaaa gaaatgttgc agaaaattcg aatagatgtt tcaaatgaaa 535921 atagaccatg agggacacat taacatttca aacaaaagag cccttgatga ttattaaaac 535981 agatctttat ggtttgttta gcaaacactt tggtaatttc atgaatattt gactagcagg 536041 aacagaaaat caaaaatgtt taaccatgat tggaagtact ccattaattc taagactttc 536101 gccgatttaa acattgaatt atttcgaaac cacaagttca aaactgtttt aaattacata 536161 ataggtgtag ttgggtggaa tggattaaaa ctcgcccttt ttgtttctga catttacaca 536221 tgtatcaaat tgctggcatt caactcctgg tcaaacaaca tcatcaaacc atacttaccc 536281 tttaaaatat ccaaatggtt gtttagcggt tgtattttag catcgattgt gctattgata 536341 tgggaggcta tagcgggaat gaggatttac aaaacgggaa atatctcttt gacttatgtc 536401 aacaattttt ccagaaacct aaattcagtg ctcaattatt ccaagttttg tgtttataat 536461 atgatcgaac gaaagggttt tcgacagaaa atgacatttt ttactttttt tcaactgaaa 536521 gattgtatta gattaatctt cacggatacc ccaaggcaag ttattaatgg tcttacgctg 536581 tggtcagttc tcgtaacagt aaataaaaac gaggatctag gcgatctgga atcatttacc 536641 ggtttgatca acaaaataaa gaacattggc cagaccaatc atgaagaagc agtgatattg 536701 tcgctgatgc tattttcctt tataatctgg gcattatttg tcttcaagtt tctgcttgct 536761 gtcatttgct cgatttttgt ttattataaa ataatcaatg atcaggaata tagcgggttg 536821 cgtgagtaca tttgtgttac cgtcagcgaa aatgttgatg aacttgttga aagacaaagg 536881 aaaaaggaaa atgatgacac gatttataag acaggtcttc tcgaatctca gacttttgac 536941 gattttaaag aagttgaaaa taaaattgaa acatctttta atgatacgtc atatgcttct 537001 aataatgatt ctatgattga gctaatagag agaagacccg aatacaaaag tcaggatgta 537061 tgtgggccca ttcccacaat gaagaaaacg gaaacaatgg aatcgttcgt tgacaatggc 537121 aatccacaat ataccactag attctctgcg attctagatt caccatatat caacagctat 537181 gaaagtaatg atataaagaa agcaaaaata caaagcagaa gcgtaaatac tccaaaatat 537241 gaggatttgt cttcttctga cattttcaac aaaatacact ctgctggaca attaaaatct 537301 acaacttcta tggagtttca cgggccatta gattctatgc caaatacaac aaacaacatc 537361 cgtaatttta atagcaacag tagtagacct agaccacctc ctttacagac aaaaagttcg 537421 attaattcaa aagctgactc gaatgataat ggaaggattt atacaccaat gaaagcgtac 537481 ttcagggagc ctgatcttcc gaggaagggt ttgctggaag atgaagatcg tacatataat 537541 tatacttaat aggctggcaa aagccctttg catatttcat gaattagata gacgtgatta 537601 gaaacagccg ttagtatgtt tctgataaaa ataatacttt ttttgtaaca ctattttcat 537661 atattggatt gataccggtt atagcacaaa cataacagcc atgaaagttt ctttgaaaac 537721 cccttttaac atttgcttgt aagagatagg ttaatttttt atagttgctg agattccatt 537781 gttggtaaag acttaatatt aggtatacag aatatactag gagttctctc tgggtatgta 537841 ggaatccaca aaagggtgtc actagttcaa cataataaca tctttttttt attccttctt 537901 tgatattttg tcatattatc ctattatttt atcaatcctt gcatttcagc ttccaataga 537961 tttgatattt gtttctcaat attatgtcat cttcatacac agtatgtgat aatatactag 538021 taacatgaat actactaaat gagtactacc ttaggggttc attacagcag cttaagcgaa 538081 agtagaaaat gaggcggata tttgttggaa taaaaatcaa ctatcatcta ctaactagta 538141 tttacgttac tagtatatta tcatatacgg tgttagaaga tgacgcaaat gatgagaaat 538201 agtcatctaa attagtggaa gctgaaacgc aaggattgat aatgtaatag gatcaatgaa 538261 tattaacata taaaatgatg ataataatat ttatagaatt gtgtagaatt gcagattccc 538321 ttttatggat tcctaaatcc tcgaggagaa cttctagtat atctacatac ctaatattat 538381 tgccttatta aaaatggaat cccaacaatt acatcaaaat ccacattctc tacaatattg 538441 atttccatcg tgtaagtttt ctgcacgaag tttattcatt caatttgaag tgcttcgtaa 538501 taatattact atgcaactta ggtacctcat atttcttaga gttcaaccaa gttggttccg 538561 ttggcgtaat ggtaacgcgt ctccctccta aggagaagac tgcgggttcg agtcccgtac 538621 ggaacgttga ttattttttt tttttcgttt ctttatagaa aaaattcaga cgatattacc 538681 ttgcgatgag ataatcttac cgcagaaaga gtgccacagt ggtaataact agttgaaggt 538741 tcatattata taaaaaactc taagaataaa aatggtatct agtgcagtta aatgtggcat 538801 atgtcgcgga gttgatggta aatataaatg tcctaaatgt ggcgtacgat attgctcctt 538861 gaaatgctat aaagatgctg caaagcatgt tcataaggaa agcgaacaac ccagggctgg 538921 tacagaagct aatgtggaag ttgttaataa cgataagatc ataaacagtt cactcgcaat 538981 gaataaaaca ttaaagacga aggcattcga tgatatatat caaaatagcg cagaattgca 539041 agagctgttg aaatacaaca cggtgaagtt ccatttggca aaggtttata gaattttgtc 539101 cagtactgtt aacgatggaa gttctggaaa aatgaacagc gatctacaaa aagaactagc 539161 tgtaaattat ttgaatacat tacgatatgg tggtatacat tataatgaag caattgagga 539221 attttgccag attttattag ataaattaaa tgcggtgaag aaataagaat tatcgttgtt 539281 agcatgattt ttaagattga gcattttatt catttttaac catataatag tgaaggtgag 539341 gactaataac aaagtacttg ttgaaagggt cgggttgctt ttaggttttt tcttctcgtt 539401 aaggatttcc cacttgtctg gcaaggcgtc aagcagactt ggaaaataat gatattatgt 539461 cagaattttt gtgtgaggcg cttctattgc aagtttgtga caccttataa taaaagtgaa 539521 ccatgtattt acatatgatt agggaaagtt ccaccatcat cttatgatct tcatggccgt 539581 tttggtcttc tttttaactt gaagtccaac ttggcgactg tacatatata catatatata 539641 gcaataagta taacaaggca acaaatcagg tcccattatt taatttgaag tcatctactg 539701 ccccataaga acctctatat tatcagtaga ttctttcttt tagggaaatc gaacctcgat 539761 attgtaagag aaacccgcgc cactcctaaa aaggtatttt gaaggagagg atgatttgga 539821 gcaacatttg gtacacttta tcctcagttt ttcgctaact acctcgcaac ttgttgttgt 539881 ggatgaaatt tttgatatta atttcaataa ataaaatata tgcaaatatc attataattt 539941 gtcaagtgcg ggaaatagac tatgcagtga tttagtgtgc aagtttgccc acttcacatt 540001 cataccaaat atttcttccc actcattttt atcgtattag cactacatac gtgacttttt 540061 agctcagctt tcggactgga tagctttact gacttacttt ctacaagcga tatcattcgt 540121 cacagtactc caaagaagtc tgggcattta attttcttct ttatcaagtc cgccattatg 540181 aaggaatgta ttgggtaata gttgacatac cgatgttctg ctggtagcat cgatgaacga 540241 aaataggtaa cggcttgccg ctgaagatat tggaaatgag acagatcatt ctagggtaaa 540301 atgcgctgta gagctagcgt caattgcgat tttcgaacac tggctgcagg tatttctgtt 540361 ttctcggctt tcattatagt aatgtgaagc tactaggaga atcacgaaac atctttttag 540421 taggatgaga acaccacgct ctcctaactg gaagtaattt ttggtatgct tagagatctg 540481 ttcctctctt atgacttctt tttcgcctac tataaactta atatcaacat atttagttag 540541 ttttttcaga gcaatacgtg tttatttttt cacaacttcg catggcatta tgtatcattg 540601 cagcgtaaat ttttacattt agtaatatct aataacatat acacaaaaaa gggacagatt 540661 tttgaattaa ataaaccaag cgtaaatcag tattgctctt accgcagtag ggggagttat 540721 ctactcctgc ttaacgtaga gaaacaatag taaaagttat gcttgtgttg gaataaaaat 540781 caactatcgg ctggcaacta atagggacac taccaatata ttatcatata cggtgttaga 540841 cgatgacata agatacgagg aactgtcatc gaagttagag gaagctgaaa tgcaaggatt 540901 gataatgtaa taggataatg aaacatataa aacggaatga ggaataatcg taatattagt 540961 atatagagat aaagattcca ttttgaggat tcctatatcc tcgaggagaa cttctagtat 541021 attctgtata cctgatatta tagcctttac caacaataga atcccaccaa ttatctcaaa 541081 attcaccagt atcttaaaga gaatgtggat tttgatgtaa ttgttgggat tccattgtga 541141 ttaaggctat aatattaggt atgtagaaag tactagaagt tctcctccag gatttaggaa 541201 tccataaaag ggaatctgca attctacaca attctataaa tattattatc atcattttat 541261 atgttaatat tcattgatcc tattacatta tcaatccttg cgtttcagct tccactaatt 541321 tagatgacta tttctcatca tttgcgtcat cttctaacac cgtatatgat aatatactag 541381 taacgtaaat actagttagt agatgatagt tgatttttat tccaacatat ctcaacatta 541441 attactcgga actttttttt gatttgttat ataataacag aaaatccaga tttgtacaga 541501 aagaaaatcc gtgatagttt aatggtcaga atgggcgctt gtcgcgtgcc agatcggggt 541561 tcaattcccc gtcgcggaga tttttttggc tactgttgcg gttacatata acatactttt 541621 tgcatatatc gtaagttatc agacaccatc tggctcactg aaagtttatt tctatgtgct 541681 ttctgaaacg tatgtatata tgagattcaa aaacaatatt taaatatttt cgatattata 541741 cctacaatgc aatgggctcc ttctaacttg agaacctctt cccgggtgtt cttacaggtc 541801 catatcctgg cggaaactcc ttatgtctac ttctgaatca gaatccaatt tcggtttttt 541861 ttcataatgt gtattttcac gatcacgctc acgctcatgt ccaagtcccg ttatgtcatt 541921 taggtttctc gtgtcccctc ttccgtgatt gattgttcgt gctttccagg attttatacg 541981 actagcattc ctaggaggat gttcgacact taaaggcggc atagaaagtc taaatttagg 542041 tgctatattt tcattaatat ttgagaggtc cccatttgat tcgttgaaac tgaaattata 542101 cttgactgcg ctgtcttttt caaaaggttc cttatgagct tcattttcgc ggtgttggtt 542161 ttcactgaac ttattaagct ttctttccct ttctttcacc ggatttaaag atttatcctg 542221 cgagtttgaa aggatatcat ttcttcgttt atagcaccaa gcccttaact cgtcagcagt 542281 cacatttgag tccaatgcac atagtatatc atccaaacag gtgaggtagc cctgatgttt 542341 ggttaaagag tttttctcat tagccacccg gtaaagtctt gtcaccgcat tggcggctag 542401 cttgaactct tgagaaagtt ccaaattaag actctcaatc gcttgctttg taggaggttg 542461 ctctggaggt aaacttgatt ccaatgaatg catttgctcc ataattgaat atattctgct 542521 cttgaattag atatgtgtcg tcggtaaaaa aggtttcttg aaatgtaatt gtatgagctg 542581 ccacgatgct aaactgcaaa acgacgtaag acaagtacag tagaatgaat ggctgcgctt 542641 caccaccaat gatttgtatc aggctaacgt gcacttggaa ggtggaaacg atgcttttgt 542701 ccagatgcct ttacgagtaa ggaaaaagaa ccatttgaaa ttttttcaag cgcactttta 542761 gaacaaattc gaaaagtgaa gaaaatatag gtggggtaac aaggaaaaga ggctacaaga 542821 gttcgttaat atattatctc cgtattgtgt aaaggaatat gtcacaattt gataataact 542881 cttcgttaag agcttgaaag aaatatttca acttgcaagt ctgggaagtg aatggagaca 542941 taaaaaacaa aaaaatctcc cgggggcgag tcgaacgccc gatctcaaga tttcgtagtg 543001 ataaattaca gtcttgcgcc ttaaaccaac ttggctaccg agagtattta attgttgaag 543061 aaagagtata ctacataaca catatacaat tgaaaaagag atttcaaata attatccggt 543121 ccttccaaga tggttcagag tgaaatttat actaaagcta agggatggaa gagaatactg 543181 acaaattaat gaacaaatac ttgaaatgag atagcaactg aggaacaaac gtaagtattt 543241 tcaacggaat tagaaatagc gacatcatga ccagcttatt cgcaaatgtg attttcggtt 543301 gggaagtatt aagtcagcat catcatatga aaatacttca taacttttct ggaggatacc 543361 ttttgaagag agaaacctgt attttgcaca gtggattaga gccgaaactt catatgctgc 543421 tgcgttattt tccatagcta tagtaacgtt ggaacaagaa tcaactatta cctatcgaag 543481 agttttcatg ttactattat attatcccat actgtgtaag aagataacat aaggattgag 543541 aaacagtaac aaagtctaat gaaagctaaa aatgcaagga ttgataatgt aataggataa 543601 tgagtgacaa agtatcaaag aaggaataaa aaaaagacat tattatgttg aactagtgac 543661 acccttttgt ggattcctac atacccagag agaactccta gtatattctg tatacctaat 543721 attaagtctt taccaacaat ggaatcccag caattatcaa aaaattcacc tttcttccaa 543781 acattaattt gttccacggg tccattttta taattacgaa ataattgtgc attggtaaca 543841 aagggagaaa gcgatatcct aaactagtag gttacagttg ataatataaa aagttggaaa 543901 atagcttaga aatgaagaag agaataacgg cttctatgcg gttgtgactt ttgacgcgtt 543961 aggcgtggtg ctaaagatgg cgaaaaaatg taacgtcttc ccaagaagta cgcttctaaa 544021 ctaaatatga ttcatagtgg acagaaagat caccattttg aatgatgggt cgtggcaaat 544081 taatactgat agaaggattg gataggactg gtaaaaccac gcaatgtaat attctttaca 544141 aaaaattgca accaaactgt aaactattga agttccccga aaggtctacc cgaatcggag 544201 gactcataaa cgaatatttg acggatgata gtttccaatt atcagatcag gcaattcacc 544261 tcttgttttc ggcaaataga tgggaaatag ttgacaagat aaagaaagat ttactagaag 544321 gcaagaacat tgtcatggac agatatgttt attctggagt ggcatattct gccgctaagg 544381 ggacaaatgg aatggatttg gattggtgct tgcaacccga tgtagggttg ctgaaaccgg 544441 atttgacatt atttttaagc actcaagatg tcgacaataa cgccgaaaaa tctggatttg 544501 gtgacgaaag atacgaaact gttaagtttc aagaaaaagt gaagcaaact tttatgaagc 544561 tattggataa agagataagg aaaggcgatg agtcaatcac gattgtagac gttactaata 544621 agggcattca ggaagttgaa gcgcttattt ggcaaatcgt tgagcctgtt ttgagtacgc 544681 atattgatca tgataaattt tcgttcttct aggaggatct gtacatatat cctagtctag 544741 tctatctaaa atacttagtc tttctaacag catatccttt gaaatttctt gtatttcccc 544801 tccaataaac atctcgtcca ttatcatata gactttgtaa aagttgaata cgatatccag 544861 ttcacagaca ttgccgaaaa atgcatctag cacctccaca aacagatgga tgtggcacaa 544921 atatatgggt tcatcgtcaa gtaagtccac acccatgaca aaatacagac ccgcatacct 544981 cctgtatatg agtttcgtcg aatcggaaaa ctctacgaag ttactctgat gcttatgatc 545041 tctggaagat atgagtctat aaatctgcgc aatggcatcc tggctacgct gaggatccga 545101 actgtgtaca tcgaaccatc tcaccaaccg caccacaccc tgcttattaa agcacagtat 545161 aaactgtact gccatttttt ttatccctta cagcaaacaa gtctccgttc ttcacaaaat 545221 aacagcacca aacgctatct caaggcaaac gttcttaatg tacctactga ataaaccatt 545281 cctccccgtt tgtatcaaaa gtatccgaaa ctgttctatg cgtgcaaaat gatatgtctt 545341 gcaaaactat tggaaagacc cttccactac aggtacagtt tagaaatgcc ggagctgcaa 545401 gtactacgtg ccggcagcat gataaacata cccgcgtcct atagccattc aagcctacat 545461 atatggtata tacaacatga acgctttagt acggtcaccc catctacaag cataacctct 545521 tgggcaaagg cgcaaatagt tgccacgtgc gagtgcggtg catgggtggc tgtcttttcg 545581 tcattggcac gaccccttgc aggtgggagg tagaaccaaa taatatccgg ttgacggtaa 545641 aagcaggttt atatatagtg ttaaagaaag gtattgtcac atcccgtcgc tacccttatc 545701 caaaccacga tatcgcacgc acaccaggaa agtaaagttg tgtaagccgt agcagttttt 545761 tacaggttaa ccgattgaat aagataatgg cgggaaacgg taaggacaaa gaggtagata 545821 aaagtccctc tgttagtact ttgaaactat tgggaaaacg cctgtttaat tccagcagtc 545881 acacggataa ctcttcgtta ctgcttagtg ccgaacaatt gggcaatggg agaagtttaa 545941 gaaaaaggcc aacgtctccg tccattagtg gcagtggtag cggtggtaat tcaccttcgt 546001 cttctgctgg ggcacggcag agatctgctt ctttacatag aagaaaaaac aatgcttctg 546061 taggattttc aaatgggtct gtgtcgtcac acaagtcctc tgtcgcattg caggacttaa 546121 ttaaacataa taataaccct tacttgaact ctccctctga tattctgggc acaggtactg 546181 gcattgcctc gacaagagat agggatagag cagttttgga tagagaaaag gaaaaagaaa 546241 gggcgagaaa caaagaaaga aatactcatc acgcgggctt accgcaaagg tctaatagca 546301 tggctagtca ccattttccc aacgagaata tagtttataa tccatacggc ataagcccaa 546361 accatgctag gccagatact gcatttgcag acactctgaa tacgaataag gagaacgatt 546421 tgagttttta catgcatgat ggtaacagca agatacggat gttgcccctt ccaattgcta 546481 atccgaacga ttttttgccc gaagatatga aacaatatag tgtccattta acggataatt 546541 tcgtatttga tacggacaat aaacctattg gttcgggtgg gtctagtgaa gttagaaagg 546601 ttaaatcaag ttacaggcaa aaggatgttt acgctctaaa aaaactgaat atgatatacc 546661 acgagtcacc cgagaagttt tacaagagat gctccaaaga attcatcata gctaagcatt 546721 taagtcataa cgttcacatc acgaatactt tttatcttct aaaagttccc acgaccacat 546781 atacaactcg tggttggggg tttattatgg aactaggtgt taaggacctc ttccaactga 546841 tggaaagaac aggctggaag aacgttccct tcaatgaaaa atattgtctt ttcaaacaag 546901 tggcccaagg tattaagttt tgtcatgaca atggtattgc tcaccgtgat ttgaagcccg 546961 aaaatgtttt aatttctaaa gaaggtatat gcaaattgac ggatttcggt atttctgatt 547021 ggtaccatgt gatacctcat gactacacta gtccagtgaa aacatgccaa ggtatgattg 547081 gctctccacc atacactccg ccagaggtaa tgtacttcga tgccaagaag cactaccccg 547141 aaaagttcca aaaaccctat aatccgttgg ccatggattc ctatgccctc ggaatcatgc 547201 tgattaccat gattaacaat atcatcccct tcatcgattc ttgtaacact gatgcgagat 547261 tcagggaatt tgaagtgtca tatgacaact tcatcaatca tcaaaaccca catttcaggg 547321 acaagggctg ccacaagccg ggtcctggtt ccgaatactc tttagcaaga aatttcaaga 547381 atactgatgc cacgcgtatc gcatggagat tggctgaccc gaaccctgca actagatata 547441 caatggatga tttatttaat gatccgtttt tccaacaaat tgaaacatgt gtcgagccaa 547501 atgatgatga cttagtaagg gttcctgaat taaggaaaag tacttctacc aatgatttta 547561 gtgaaaattc attagatgca ccccatgatc aagaggtcat tcacacgtct aatccattcc 547621 taaaaaagga aacgctcact tctaaaccaa gatcgatgtt ggaaattgca gaatctcctt 547681 ccttgaaaca aaaatccaag gtaaaagata gcgcaaagac caaaacacac gatgttgggg 547741 atgaaggggg gaatgaaagc accaaaccta agcagcaaga taaaaaggaa aatttgaaga 547801 aagatgaggt caagaacggc gacaaggaca aagtcattga agaggctacc acgactaatg 547861 tggacagcat attggaaaaa ccaacaccaa cctccacaaa agtagaggac aacttaagcg 547921 aagatgattc cacaatgaag gaattaaagt cgatgctaaa ctccacccct actacaccaa 547981 cacataatgg ccccactccg ctccctgcaa aggctggcac tcaattagat aagcgtatga 548041 gcgacctatc actcaaatcg gaaacaccgg cttctacaaa gaactttagc gcaccgaatg 548101 tttcgtcatc aagcaattca ctgagaagcc tcggaagtcc aagcgtgtca tcctcgaaaa 548161 agaagaaggt aattcaccac cacttggaca ttaccaacag cgttacaaac atgtcatccg 548221 tgagcgcctt tatctcaaga tagacgttag gacttcttta attccctctt ttatgcttta 548281 gtatcgtcat attctttcat acccttcctt ataagctttt tatataaaat atcccaccgg 548341 gaaaagataa agaacggaag ataaatcaaa caatgaaata aagcacacac atataaatcc 548401 acatatgtac ttatatattt tacttcaaac aataaacaaa cattttatta tttatttttc 548461 ccgtacatcg atgtacgtga tcggtttttc tcattcctct cggatccttc gggaccacca 548521 tgtctcaccc accaaggtca aaaaaaaaat aaaatcggac gagaaaagta ttgggcaaac 548581 aacaattatc cacgtgctta tcacgttttt ttatttaatg tagaatgtaa accattatac 548641 cttaaagata aacactttgt taattaatca ttttagttgg cggtcatttt catttctgct 548701 acaagtacca acatcaagtg cttaaaatat aatacggttt tctacacttt tattaacgat 548761 gaactctctg gcaaataata ataagctttc tactgaggat gaggaaatcc attcggcaag 548821 aaaaagaggc tataacgagg agcagaacta cagcgaggcc aggaaaaagc aaagagatca 548881 aggcttgttg tcacaagaga gcaatgacgg aaatattgac tctgctctgt tgagcgaagg 548941 ggctacgcta aaagggactc aaagtcagta tgaaagcgga ctgacgtcta acaaagatga 549001 gaaaggaagt gatgacgaag atgcgtcagt ggctgaggct gctgttgccg ctaccgtcaa 549061 ttatacagac ttaatccagg gccaggaaga tagttctgat gcccacacat ctaatcaaac 549121 gaacgcgaat ggtgagcaca aggattccct taatggggaa agagccataa ccccatcaaa 549181 tgaaggagtc aagccaaaca cctccctgga gggaatgacg tcttcaccaa tggaatctac 549241 acagcaatct aaaaacgaca tgctcatacc attggcagaa cacgatcgtg ggccagaaca 549301 ccaacaggat gatgaagaca atgatgacgc tgacattgat ctcaaaaagg atataagcat 549361 gcagccgggt cgtcgtggaa gaaaacctac tactttggcc acaacagacg agtggaaaaa 549421 gcaaagaaaa gactcccata aagaagtcga aaggcgtcgc cgcgaaaaca tcaacactgc 549481 aatcaacgtt ttaagcgacc tcctgcccgt gagagaatca agtaaggcag caatattggc 549541 gtgtgccgct gaatacattc aaaaattgaa agaaaccgat gaagcaaaca tcgaaaagtg 549601 gacgttacaa aaattgctta gcgagcaaaa cgcatcgcaa ttagccagtg caaatgagaa 549661 actgcaggaa gaactgggaa atgcttacaa agaaatcgag tacatgaaac gcgttttaag 549721 gaaggaggga atagaatacg aggatatgca cactcacaag aaacaagaga acgaaagaaa 549781 aagcactagg agcgataatc cacatgaggc ttgagagtta aaaatagata gctaaatgta 549841 tttcgagtct ccctatgtat ctgcgtctct gccccatagc acctctgtta agtttttatc 549901 aatattccat cggcatattt gaaaccgccc ggatggtatt agagaatcac tcagcctcaa 549961 actcagcaag taaaagagga cgggacggac tttcaaatat gtctttgtac gttattgttt 550021 ttcatcccta aatggcttag taaaaaagtt ttgccaagaa ttttttgacg ttcaatggaa 550081 aaatcgccaa gagaaatacg cacaacctcc gttttcccgc cttttatcaa aaaatcttag 550141 ttttcccttc cttttttttt ttttgggtcg cagaaaagaa aaaagatagt agtggagagg 550201 attacctgaa aaaaacaggc aaaaacgtca catccttgaa ggtccgcgac aatcacgggc 550261 ctatttctac tttggggctt tgcttgatta tttaagaaga aacattggac gaagatcaag 550321 taagagtgca cttgtcttta gtctggcatt ccgctatttg tatcttatat agttaacaac 550381 aactgttatt tactttctgg aaaacaacca acgtttattt ttatgaatta gaatcattga 550441 gattgtctaa acgagaggaa gagaaagaaa gagagaaaga gaaaagaaag cgaagcaaga 550501 tacaattcca atgatgttat cactgcgcag gttctccatg tacgttttga gatctctgcg 550561 gcttcacttt aaaaagataa tcattactct tctaactatc cagttactat tcattaccat 550621 atttgtattg ggcggtcgct cgtcgattat tgacggtaac tggaagtcat tcatggcgct 550681 ctttttcaaa ccgcttgctt acactaacag aaacaacaac catgcttctt tcgatctgag 550741 atcaaaagac aacgtagcca aactttacga aaaaatgaat tttgatactt caggcaaatg 550801 gatcgacacg tacaccttga agaataatct tctcactgtg aaaatgggtc ctgaaaaagg 550861 gcaagttctt gattcggtag atgaattgag atattacgat aacgacccaa ggctggtatg 550921 gtcagtttta ctagatcact tattagaatc agattccaat gaatacgcat tttcgtggta 550981 cgattgggct aattttgact ctacaaacaa actcattgca ctgagacaca cgaacatatc 551041 ttgccagttc gtttgcgagg gtgcctttga taaaaatgtg ctagaaatgg tagagagtga 551101 agtccaagag cctttattcg tcacaaatag gaataaatat gacgaatcgc tctggtacaa 551161 cagggtaaga aaggttgtcg attctaattc tgtgcagcaa gccatacatg atcactgcat 551221 gaataatgac gcgtattcca atggtactcc cttcgaattg ccttttatca taagcgaaat 551281 ttctgaaagg ttgaggccag aagtgtatga cttacaagcc aaaaaccact tgttatattc 551341 taactttact ccactgtcat taaccgtact ggacagcgat aaagatgcat acagaatcaa 551401 tttgaagaca acagactctt ccaaatcaaa tatagtacag acaaatctac tacagaatta 551461 cattaagagg cacagaaatg aaatggtaaa tggcgacctc attttcaacc acacttccat 551521 gtttgaaaaa tttttacatc atggatccac taaaaaaagg aaacttgacg ttgaagcgtt 551581 ggataaaaca atatacgctg gagagtatct agaactatca ccatctgatt tccaattcaa 551641 tgcaaaagag aggatcattg aattagagac caggctcagg tctgaaggcc taccatctca 551701 tgatacccac tatttacgaa gtttaaagac gtccgtaaat acgtcccctg cattacagca 551761 aaagtatttc gcagaggcct ctgatattac ggacgcgact gccgatggtc atcatagaga 551821 caggcgattt ttctcaatcg gacataatct cctaaatgac cctcaggagt ttgaagcaag 551881 attgaattct ttgatcagaa attttcagaa atttgttaag gctaacggat taatttcctg 551941 gctatcgcat ggtacattgt atggatatct atatgatggt ctgaagtttc cctgggatgt 552001 cgaccatgat ttacagatgc ccattaaaca tttacattac ttgagtcaat atttcaacca 552061 atccctaata ttagaagatc caagagaagg taatggaaga ttcttactag atgtaggaag 552121 cgcaattacg gtaggagttc atgggaacgg cgaaaacaat attgatgctc gtttcatcga 552181 tattgactca ggtatataca ttgacatcac gggacttagc gttagttccg atgcggctaa 552241 acagtacatg tccaaatttg tagaagaaga aagctcgggc gaaagctttt ctgcccttat 552301 tgaagactat aagtttgacg aaaacgacta ttttgacgag gtggatggta gagaaggttt 552361 agctaaatat accatacatg aattaatgga atgggttaat tctcatccag acgactttac 552421 ggatgcagaa aagaatttag tcaccaaaac atacaagaaa gagcttgcaa tttcgagaag 552481 cgattatgct gaaaaagact tgtctccgaa acaaaggtat ttggtaaatg agaagtataa 552541 cctttacaat tgtagaaacc agcatttttc cagtctaaac atcatatcac ccttgagaaa 552601 tacaatgttc agcggtgtgt cagcatttgt tcctaatagg cccatagcaa cattgaataa 552661 tgagtataaa gttccggcaa aatacgggct tttgtcattc caaggtaagg tgtatttacc 552721 ggaattcaga tactggttct cgtttgcaga catgaagaag tttgcaaatt tgcagctgaa 552781 agaacccaag ataacacgac tggaaagtcc cttaaatgat ttaaaattca gcgacataag 552841 cctactgata acaaacattt taaaatgtgg gtttcactcc gtatttgcca gcttatttaa 552901 ttcttttgac agtactgttt acagactcaa agagcttgaa atacagtatg atcctagctt 552961 gagtgaggaa gaaaaaagta gtctattaaa aactctacgg cgaggaatgt caaaaaaaat 553021 aaaatcacca gaaaaagatc cgatcatata tatatacgaa agaaagttat gggaaaacgt 553081 ggaaaagttg ttgaatgcgt caaacatcta caacattgct tcacaagttg agaaggaaaa 553141 aggtaaagag tttgttgaac ggtcccagca agtatatgaa agaaactttg acggcttcag 553201 acttcccgat ggcggcaaca gtaagactgt aaatgatctg aattctaagg gcttaaatct 553261 ctttggtgat aataagaaaa cttcaaacaa tatatttggt tcagaccaaa aatattaaaa 553321 aacgttccct tatccttcgg aataggataa taacaaaaac cattatttat tcattcttgc 553381 ctcacttaaa ttcggccctt acggcgacat ttcaataaca taaatatgcg tgtaacctta 553441 ttaatttata atgtctaatt tattataata ttccttcacc taaacacttc aaattggacc 553501 tcacgcaata tagcgccttc tagacccttg cccaaattac ccagcaactc tacgctttca 553561 ttgagagaat caagcgaact ctcatcatca tcctgtgaac ctttaggttt tttaccgtta 553621 aatttataaa tgccagaact tcctgcaaaa atcgtggtac catcttcagt accacatctg 553681 ttagctagca ccaaaatcgc attctttcct tggaacttcc aaggctgtcc aagggaggtt 553741 cccaaaaatg tcttttccag tactgtatcc tttatcactt cctcagaatc caataagtct 553801 attgtgtcct ccttgtgctt tccatcttta taatattcat gatctagggg cattctagtt 553861 ttgcccaaaa tgctttcgat aagagatgaa tttttaaacc aattaattct ggatttaaag 553921 tacaaaaaag gaaaaaatcg tagaatccag tagtttacgt ttgacatatc tggttcatcc 553981 atatccttat attcacttgt actgtcgtca gaaggcactc tgggcgtacg ttgcgaatca 554041 ccaattttaa gctggtaaat tccttgagat cctgccaaag gcaacccttg ctcctttaaa 554101 gcgaaagcta ttttgttctt agcggcttct aataatgaat tgttatgtaa cgtctgtttg 554161 tctgtgatag aagtagagtt taaccacgcc attggacata gaatcaattc aacattattg 554221 tcaacgcaaa aagaagagaa ttcaaagtga ttaaaggggg ccatgaattt gtagggactt 554281 aagtccatac aaatacctat tgatgctttc aaagtcacat ctctgttgta agagtcctca 554341 ttagaaagct tagcacactt tgaaaaatcc atgggaaacg tctgaaatcc ctctggattc 554401 tcctcgcaat cccaattcat ttctgtatca tagagaaaag tctttctgta attaaagatc 554461 tgctccccct gcggatttac taccagggca gaattgtata gcttctgttc atcatcatct 554521 tcaggatatc ctattatagt gtagcattga aatttctcgg atattgattt agccagttca 554581 aaagagggcc cttcatcttt cttagtaaca taaggtaaaa tatcttttct ggcatgaaaa 554641 ctgtaacctg tcaatgcaaa ttcggggaat agtattatgt ctggtttcac ataggtggca 554701 cttttcgtaa ctttatccaa tattgaccat gttctcttaa ttgtttgatc tacttgccca 554761 atttgcggat tgagttgaat tactagtacc tttagtgata ctaaaagttt tgtgctcatc 554821 ttagcaccat gaattgcgtc tattagcatt cactgaatgt cacgatagag ttatcgctgt 554881 aaactagcac tttttagcat tgaaatgctt aaaatgtgtg aaactaaagt ggttttattt 554941 ccaaagaagg gttatccctt actagggcaa cgaatgaata tctattaggg ctataaaaca 555001 aaaatagtta agtgagatat ataccctctt gaatggtgca gggtaaataa ttatatatcg 555061 ttacgaacga aagatgaaaa atatgaaaaa aaaaaaaatc aaatttatgt caagtgaagg 555121 gcattgcatg gcaagtgtaa agaatccaag aagaaaagaa aggcttaaag caatccaggt 555181 tagtacttat aagaatgtct gttgtaggat cgttaatttt ttgcttggac tgtggtgatc 555241 tcctggaaaa tcctaatgcc gtattaggct ctaacgttga atgcagccaa tgtaaagcca 555301 tatatcccaa gtcacaattc tccaatttaa aagtcgtcac cacgacggca gacgatgcgt 555361 ttccatcttc tcttagagcc aagaaatccg tggttaaaac ttctttgaag aagaacgaac 555421 tgaaagacgg cgctactatc aaggaaaagt gtcctcagtg tggaaatgaa gagatgaact 555481 atcatacttt acagttaaga tctgcagatg aaggtgctac tgtcttctat acatgcactt 555541 cctgtggtta caagttccgt accaacaatt gattgggttg tgttcgcaca tattacaatt 555601 tgtacattaa tatcatcccc gctttcatca tgtgaacatc tatagaacat catttataaa 555661 aacaaaaaat ctatgtactg acgatataat agcgtacatt atcatattat tcttactatt 555721 tatcatactc atcgcatcta ctgttctcga gaacgtgtaa agtgatttat gccattgaat 555781 gaaaaatttt gttaaggaac aactagaaat ataatagtgt cttggtggat gtggcaaatg 555841 aggtgtgcgt gataaagagc tacaaactca aagtaataac agctatcatc catttttata 555901 gcaatatttg aaaatggctg ctcgtccaca acaacctcct atggaaatgc cggatctgtc 555961 gaacgccatt gtggcacaag acgagatggg tagacccttt attatcgtga aggatcaagg 556021 taacaagaag agacagcacg gattagaggc caagaaatca catatattgg ctgctagatc 556081 agtagcttct attatcaaaa cttcgttggg tccccgtggg ttagataaga tcttgatttc 556141 acctgacggt gaaatcacca tcactaacga tggtgctaca attttgtccc aaatggagct 556201 agataatgag attgcaaagt tgttagtaca actttccaaa tctcaagatg atgaaattgg 556261 tgatggtact actggtgttg ttgttctggc aagtgcgcta cttgaccaag cattggagtt 556321 aattcaaaag ggtatacatc caatcaaaat cgctaatgga tttgatgaag ccgccaaatt 556381 agccatttcc aagttagaag aaacatgtga cgacatttct gcgtcaaacg atgaattgtt 556441 cagggacttt ttattgaggg ccgccaaaac ttctttgggc tccaaaattg tttccaagga 556501 tcatgataga tttgctgaaa tggctgtgga agccgtcata aatgtcatgg acaaagatcg 556561 taaagacgtg gatttcgatt taatcaaaat gcaaggacgg gttggcggat ctataagcga 556621 ttcaaaattg attaatggtg tcattttgga taaagatttt tctcatccac aaatgcctaa 556681 atgtgtttta ccaaaagagg gctctgatgg tgttaagtta gctatattaa cgtgtccatt 556741 tgaacctcct aaaccaaaga ccaagcataa attagacatt tcttcagtag aagaatacca 556801 aaaattacag acttatgaac aagataagtt caaagaaatg atagacgatg tgaagaaagc 556861 gggcgcagat gttgttatat gccaatgggg gtttgacgat gaggccaatc atctacttct 556921 acagaatgat ttacctgccg taagatgggt aggtggccaa gaactagaac acattgccat 556981 ttccacaaac ggtcgcattg ttccaagatt tcaagacttg tctaaggata aattaggtac 557041 atgttccaga atttacgagc aggagtttgg tactactaag gatcgtatgc tgattatcga 557101 gcaaagtaaa gaaacaaaaa ctgtaacatg ttttgttcgc ggttccaata aaatgatcgt 557161 ggatgaagct gaacgtgcat tgcatgactc actatgtgtg gtacgtaact tggttaaaga 557221 ctcacgtgta gtttacggtg ggggagcagc cgaagtgact atgtccctgg ctgtctctga 557281 ggaagctgat aagcaacgtg gtattgatca gtatgcattc cgtggattcg cccaagcgtt 557341 agacaccatt ccaatgactt tggctgaaaa ttctggtctt gatccaatcg gaactttgtc 557401 tacattgaaa agtaaacaac tgaaagaaaa gatttccaac attggtgtcg attgcttagg 557461 ttacgggtct aatgacatga aggaactatt tgtcgttgat ccatttattg gcaaaaagca 557521 gcaaattctt ttagctactc aattatgtag aatgatttta aagattgata acgtcatcat 557581 tagtggtaaa gatgagtatt gattttgtat aaataaataa taaaagataa gttttaatca 557641 catatcccac aatttttttt ctcagatcag catttggggt tacttgattg tacatatacg 557701 tgtatataat cagttgtata cgtatattta aatgaagtga ggggcgtttc agttatttgc 557761 atttgttttt gtaccttttt ccttataaga tgagtcatga ctcaataatc aaaccatgtt 557821 gaaaaggctg aaatttctaa caatttccgg accatattcc tcataatctt tcttagtgtg 557881 acagtagcct ttgaattcgg ctgtttgtgc cagcagcgag ccaccaaacc agacagcgtt 557941 tctctgcttc cgatgagaaa tcacggaaac atctacacca gtcgatttag ttccacttaa 558001 cagctcactt tgtgcgattc tgttatttac gatagacttt agatctcttt gtaaacgacg 558061 tccaaaatct ttgaacatgg tagacccacc tgatagtaca atattgttgt ataaaccttt 558121 acggacgtca atagggcaag cctggatagt ttgatccact accgtgggta aaggagtcaa 558181 gaagtctgag gatgcaattt ctggattgaa gaagatttca ggtgctaaga atctttcgta 558241 accaatatct acgacttttc tccttgtctt ttcttggttt tccaccacaa attgggcaaa 558301 tttagaagga tctttatcga atttgttaaa ctcctttaca atatctggac agacgtaaca 558361 gtattcttgc ttaatctttt cggcagttct caaggaagtg tctgcttcac cacgttctct 558421 tagcaaggat tggatgaaca atgtgatgtc tctaccggct attggaatgt ttttaattgc 558481 tgagccaatg acgtaacctt ccgccactgg gatgacgtgg gtgacaccat caccagaatc 558541 tataacagta ccagttaatg atctatccgt gacttttgaa gaggtccatg acgcagccag 558601 agccaaaact gcttgcacag caatatatag accagcacaa ttaaatgatt caaaaaaaat 558661 ctccgccact tgctctctgt tttctggagg attcagtggt ggttcggtca ataggaaaaa 558721 atgatcttca ggctctgttc ttaaatactt gaagatggaa ttttcccaga atctttccat 558781 gtgatcccaa ttttccactt gaccgtgtct gattggatag ctcaaagagt aagagggtcc 558841 ttgggatgct actaaagcct catttccaat atagaaatcc aaatcttctg tacctctttt 558901 accggataaa ttattagaca gcaaaccacc tgttgcacca ttgaaattgg ttgcagaggt 558961 ggaatttcca aagtatgatg cttcattact aactgctgag ggcgcaccaa cgcccgagga 559021 cttctttgta tttgaaggtg cagctgtggc tattgcagta gggaagaccc aggagggaga 559081 atcattaccg gcgaaaccga gcttggtcag cccggtacca ttgtccatga caacagcggg 559141 attgtttaag tatgacattg aatcctaatt tcttgctcaa tcgtgaggcc ttacggtagg 559201 gccaattctt gattaaacta ctctcatata tttttgtttg aaacttttga aaaggggttc 559261 tcgccatttt gaagccgcgg acagccgggt gactactgaa agtccttatc gaagggtctt 559321 cttgagctta cgttaaaaaa gagccatagt agcttcacga gagagtcatt ggtaaagtga 559381 aacatacatc aaccggctag caggtttgca ttgatatgga accgcatgag gagcagattt 559441 ggaagagtaa acttttgaaa gcggctaaca acgatatgga catggataga aatgtgccgt 559501 tggcaccgaa tctgaatgtg aatatgaaca tgaaaatgaa tgcgagcagg aacggggatg 559561 aattcggtct gacttctagt aggtttgatg gagtggtgat tggcagtaat ggggatgtaa 559621 attttaagcc cattttggag aaaattttcc gcgaattaac cagtgattac aaggaggaac 559681 gaaaattggc cagtatttca ttatttgatc tactagtatc cttggaacat gaattgtcga 559741 tagaagagtt ccaagcagtt tcaaatgaca taaacaataa gattttggag ctggtccata 559801 caaaaaaaac gagcactagg gtaggggctg ttctatccat agacactttg atttcattct 559861 acgcatatac tgaaaggttg cctaacgaaa cttcacgact ggctggttac cttcgagggc 559921 taataccttc taatgatgta gaggtcatga gactcgctgc aaagactctg ggcaagttag 559981 ccgttccagg aggtacatat acctctgatt tcgtggaatt tgagataaag tcttgcttag 560041 aatggcttac tgcctccacg gaaaagaatt cattctcgag ttcgaagcca gaccatgcta 560101 aacatgctgc gcttctgatt ataacagcgt tggcagagaa ttgtccttat ttactctacc 560161 aatacttgaa ttccatacta gataacattt ggagagcact aagagaccca catttggtga 560221 tcagaattga tgcgtccatt acattggcca aatgtctttc caccctacga aatagggatc 560281 ctcagttaac tagccagtgg gtgcagagat tggctacaag ttgtgaatac ggatttcaag 560341 taaacacatt agaatgcatc catgcaagtt tgttggttta taaggaaatc ttgtttttga 560401 aggatccctt tttgaatcaa gtgttcgacc aaatgtgtct aaattgcata gcttatgaaa 560461 atcataaagc gaaaatgatt agagaaaaga tttaccagat tgttccccta ttagcatcgt 560521 tcaatcctca attatttgct ggcaaatatt tgcaccaaat tatggacaac tatttagaga 560581 ttttaaccaa tgctccagca aataaaatac cacatctcaa agatgacaaa ccacagattt 560641 taatatcgat tggtgatatt gcatatgaag tcgggcccga tatcgcacct tatgtgaaac 560701 aaattcttga ttatattgaa catgatttac agacgaaatt caaattcaga aagaaatttg 560761 aaaatgaaat tttctactgc atcggaagat tggcagttcc cttgggcccc gttctaggta 560821 aattattaaa cagaaatata ctggacctga tgttcaaatg ccctctttcc gactatatgc 560881 aggaaacgtt tcaaattctg actgagagaa taccatcact aggccccaaa ataaatgacg 560941 agttgcttaa cctagtctgt tcaaccttat ctggaacacc atttatccag ccagggtcac 561001 caatggagat accatcgttt tcgagagaaa gagcaagaga atggagaaat aaaaacatcc 561061 tacagaaaac tggtgaaagt aacgatgata ataatgatat aaaaatcatt atacaagctt 561121 ttagaatgtt aaaaaatatc aaaagcagat tttcgttggt ggaattcgtg agaattgttg 561181 cactttctta cattgagcat acagatccca gagtaaggaa actagctgcg ttgacatctt 561241 gtgaaattta cgtcaaggat aacatctgca aacaaacatc actacactct ctgaacactg 561301 tatctgaagt gttatcaaag cttctagcca ttacgattgc ggacccttta caagatatcc 561361 gtttagaagt tttaaagaat cttaatccat gtttcgatcc ccagttggca caaccagata 561421 atttgagact cttgtttact gcactgcacg atgagtcgtt caatattcag tcagtagcaa 561481 tggagcttgt cggtaggttg tcttccgtaa accctgcata cgtcatccca tcgataagaa 561541 aaatactact ggaactgcta acaaaattaa aattctcaac ttcttctcga gaaaaggaag 561601 aaactgccag tttgttatgt actcttatca ggtcgagtaa agatgttgcg aaaccttata 561661 tcgaacctct tttaaatgtt cttttaccaa aattccaaga tacctcttca acggttgcat 561721 caactgcact gagaactata ggtgagctat ctgttgtagg gggcgaagat atgaagatat 561781 atcttaagga tttgtttcct ttaattatca aaacatttca ggatcaatca aactctttca 561841 agagagaagc tgcacttaag gcccttggtc aacttgcagc ctcatctggt tacgtgatag 561901 atcctttact cgactatccc gaattattgg gtatattggt gaatatattg aagacagaaa 561961 actctcaaaa tattaggaga caaacagtca ctttgatagg tatactggga gctatcgacc 562021 catatcgcca aaaagaacgt gaggttacct ctactaccga tatatctaca gaacagaacg 562081 ccccgcctat cgacattgct cttctcatgc agggcatgtc tccttcgaat gatgagtatt 562141 ataccactgt tgtcattcac tgcctgctaa aaatcctaaa agatccatcc ctatcatctt 562201 accacactgc cgtgatccaa gcgattatgc atatttttca aacccttggt ctaaaatgtg 562261 tttcattctt ggaccagatc atcccaacta ttttggacgt aatgcgtaca tgctctcagt 562321 cactattaga attttacttc caacagcttt gctctttgat tattatcgta aggcaacaca 562381 taagacctca tgtcgattct atattccagg ctatcaaaga tttttcttcg gttgctaagc 562441 tacaaataac gcttgtaagt gttattgaag caatatcaaa ggctctggag ggtgaattca 562501 aaagattggt ccctcttact ctgaccttgt tccttgtaat tttggagaat gacaagtcta 562561 gtgacaaggt cctctccaga agggtattga gactgttaga atcgtttggt cctaacttag 562621 aaggttattc gcatttgatt acacccaaga tagttcaaat ggcagaattc accagcggga 562681 acctacaaag gtctgcaata attactattg gcaaactggc caaggatgtt gacctttttg 562741 agatgtcctc aagaattgtt cactctttac ttagggtact aagttcaaca acgagtgacg 562801 aactctcaaa agtcattatg aatactttaa gtctactgct aatacaaatg ggcacatcct 562861 ttgctatctt catccctgtc attaatgaag ttttaatgaa gaaacatatt caacacacaa 562921 tatatgatga cttgacaaac agaatattaa acaatgatgt tttacccaca aaaattcttg 562981 aagcaaatac aacggattat aagcccgcgg aacaaatgga ggcagcagat gctggggtcg 563041 caaaattacc tataaaccaa tcagttttga aaagtgcatg gaattctagc caacaaagaa 563101 ctaaagaaga ttggcaggaa tggagcaaac gtctatccat tcaattatta aaagagtcac 563161 cctcccatgc tctaagagct tgttcaaatc ttgcaagcat gtattatcca ctagccaaag 563221 aactttttaa taccgcattc gcatgtgttt ggaccgaact ttatagccaa tatcaagaag 563281 atttaattgg gtcattatgt atagccttat cttctccctt aaatccacca gaaatacatc 563341 aaacattgtt aaacctggta gaatttatgg aacacgatga caaggcatta ccaataccaa 563401 ctcaaagcct gggcgagtat gctgaaagat gtcacgccta tgccaaagcg ctacattata 563461 aagagattaa atttattaaa gagcctgaga actcaactat tgaatcattg atcagcatta 563521 acaaccagct gaatcaaacg gatgctgcaa ttggtatatt aaagcatgcc caacaacatc 563581 attcacttca attaaaggag acatggtttg aaaaattaga gcgttgggaa gatgcactac 563641 atgcttataa tgaacgtgaa aaggcaggtg atacttccgt gagcgttaca ctcggtaaga 563701 tgagatccct tcatgccctt ggcgaatggg aacagttgtc gcaattggca gctagaaagt 563761 ggaaagtttc gaagctacaa actaagaagc taatagctcc cttggcagct ggtgctgcgt 563821 gggggttggg agagtgggat atgcttgagc aatatatcag cgttatgaaa cctaaatctc 563881 cagataagga attttttgat gcaattttat acttgcacaa gaatgattac gacaatgcta 563941 gtaagcatat attaaacgcc agagatttgc ttgtgactga aatttccgcg ttgatcaatg 564001 aaagttataa tagagcatat agcgttattg ttagaactca aataataaca gagtttgagg 564061 aaatcatcaa gtataaacaa ttgccaccta attccgagaa aaaacttcac tatcaaaatc 564121 tttggacaaa aagactgctg ggctgccaaa aaaatgtcga tttatggcaa agagtgctta 564181 gagtaagatc attggtaata aagcccaagc aagacctgca aatatggata aaatttgcaa 564241 atttgtgcag aaaatctggt agaatgaggc tagcaaataa ggcattgaat atgctactag 564301 aaggaggcaa cgatcctagt ttaccaaata cgttcaaagc tcctccccca gttgtttacg 564361 cgcaactaaa atatatttgg gctacaggag cttataaaga agcattaaac cacttgatag 564421 gatttacatc caggttagcg catgatcttg gtttggatcc gaataatatg atcgcgcaaa 564481 gtgtcaaact ctcaagtgca agtactgctc cgtatgttga ggaatacaca aaattattag 564541 ctcgatgttt tttaaagcaa ggtgagtgga gaatagcaac acaaccgaac tggagaaaca 564601 caaatccgga tgcaattctt ggttcttatc tattggctac acatttcgat aaaaattggt 564661 acaaggcatg gcataattgg gccttagcta attttgaagt aatatccatg gttcaggaag 564721 agactaagct caacggaggt aagaatgatg atgatgatga cacggcagtt aataatgata 564781 atgtgcggat tgacggtagt atcctaggaa gtggttcttt gactattaat ggcaacagat 564841 acccgctaga gcttattcaa agacatgttg ttccagcgat caagggcttt tttcattcaa 564901 tatctctatt agaaacaagt tgtttgcaag acacgttgag gttattgact cttttattta 564961 actttggtgg tattaaagaa gtctcacaag ccatgtatga aggcttcaat ttgatgaaaa 565021 tagagaactg gcttgaagtc ttaccacagt tgatctctcg tatacatcag ccagatccta 565081 cggtgagtaa ttcccttttg tcgttgcttt ctgatttagg gaaagctcat ccacaagctc 565141 tcgtgtatcc tttaactgtc gcgatcaagt ctgaatctgt ttcaagacaa aaagcggctc 565201 tttcaataat agagaaaatt aggattcata gtccagtcct ggtaaaccag gcagaattag 565261 ttagtcacga gttgatcaga gtagccgttc tatggcacga attatggtat gaaggactgg 565321 aagatgcgag ccgccaattt ttcgttgaac ataacataga aaaaatgttt tctactttag 565381 aacctttaca taaacactta ggcaatgagc ctcaaacgtt aagtgaggta tcgtttcaga 565441 aatcatttgg tagagatttg aacgatgcct acgaatggtt gaataactac aaaaagtcaa 565501 aagacatcaa taatttgaac caagcttggg atatttatta taacgtcttc agaaaaataa 565561 cacgtcaaat accacagtta caaaccttag acttacagca tgtttctccc cagcttctgg 565621 ctactcatga tctcgaattg gctgttcctg ggacatattt cccaggaaaa cctaccatta 565681 gaatagcgaa gtttgagcca ttattttctg tgatctcttc gaagcaaagg ccaagaaaat 565741 tctccatcaa gggtagcgac ggtaaagatt ataaatacgt tttaaaggga catgaagata 565801 taagacaaga tagccttgtt atgcaattat ttggtctagt taacactttg ttgaagaatg 565861 attcagagtg tttcaagaga catttggata tccaacaata cccggctatt ccattgtcgc 565921 ctaaatctgg tttactagga tgggtaccaa atagtgacac attccacgtt ttgatcagag 565981 aacaccgtga tgccaaaaaa attccgttga acattgaaca ttgggttatg ttacaaatgg 566041 cccccgatta tgagaatttg actcttttac aaaaaattga agtattcacg tacgctttag 566101 ataatacaaa aggccaagac ctttataaaa tattatggtt aaagagtagg tcgtcagaga 566161 catggctaga acgtagaaca acttatacga gatctttagc agttatgtcc atgactggtt 566221 atattctggg actaggtgat cgccatccaa gcaacctgat gctagataga atcaccggta 566281 aagttatcca cattgatttc ggcgattgtt ttgaagctgc catcttaaga gaaaagtatc 566341 cagaaaaagt gccatttaga ctaactagga tgttaacata cgcaatggaa gttagtggaa 566401 ttgaaggcag tttccgaatt acttgtgaaa atgtcatgag agtcttaaga gataataaag 566461 aatcattaat ggcgatcttg gaagcttttg cgcttgatcc tttgatccat tggggatttg 566521 atttaccgcc acaaaaactt actgagcaaa ctggaattcc tttgccgttg attaatccta 566581 gtgaattatt aaggaagggg gcaattactg tcgaagaagc ggcaaatatg gaagcagaac 566641 aacaaaatga gaccaaaaac gccagagcaa tgcttgtttt gagacgtatt acagataaat 566701 taacgggcaa tgatatcaag aggttcaatg aattagacgt ccctgagcag gttgataaac 566761 tgatccaaca agccacttct attgaaaggt tatgtcaaca ttatattgga tggtgcccat 566821 tctggtgact gcggtgtcat ttttcatttc gtgctttgtt tactatttat tttttttgta 566881 ttacgcattt gtatacgtgt gcaagtattg tgtattatta ttattattat cattattttt 566941 gtaatatctc gtcattatgt gaaatgaagg atgatataag gtacataaat tgtgaaatca 567001 actccattta aaacaacttt attggataga tggcacatgg tacttttcac aataggtatt 567061 ggcaatatca gtccattttg ttatgagcgg atgtttttct tgcaagtcaa agtttggatc 567121 aaatatggac ttactaagta ctttgttaat gcgtaattct ttttgagcat caatatatgc 567181 cttactgagg tcctcatctt catcaccaaa acgtgttcgt aggccaagta aaatccccat 567241 aattatgcca acttgtttcc ctaatttagc gcccgttggg aaaccatcat tgaaaccctc 567301 ttgcagcttt tcttctttag aactcactat tccgtccaag taccccctct tgctatgatt 567361 ctctcttaac ttcactaaat ctggagatcg ttcagtttcg acatcactgt ctgatgccca 567421 tacatcgtcc caagtattcg acatctctat atactattgt aacactgttc cttttttgtt 567481 ctcttctatc aaaaaccttt ctcatcgtta tttttcactc ttttacttcg cgtatttcaa 567541 agcaatcagg aagtaactca agcgaacaag tcaatgctat aagagaagta aaatagagag 567601 acagcgagaa atactggggg aaagtattgg caatcacttg agatgtttga agggtttggt 567661 ccaaataaaa agcgtaagat atcaaagtta gccgcagagc aatcattggc acaacaaccc 567721 tgggttgaga aatacaggcc caaaaaccta gatgaagtga cagctcaaga tcatgccgtt 567781 actgttttga agaaaacctt aaagtcagct aatctaccac atatgttgtt ttatggtccc 567841 ccaggaactg gtaaaacgtc taccatttta gcgctaacaa aagaattata tggacccgac 567901 ttgatgaaat caagaatatt ggagttgaac gcttctgacg aacgtggtat ctctattgta 567961 agagaaaagg taaaaaattt tgcaagattg actgtatcca agcctagcaa acatgacttg 568021 gagaactatc cgtgcccacc gtataagatc attattctcg atgaggccga ttcaatgact 568081 gccgatgcac agagtgcatt acgtagaaca atggaaacct attcaggagt aacaagattc 568141 tgtttgattt gtaattatgt gacaagaatt attgacccgc tagcgtcccg ttgttccaaa 568201 tttagattca aagccctaga cgcaagtaat gccattgacc gtttgaggtt tatcagcgaa 568261 caagaaaatg ttaaatgtga tgatggagtt ttggaaagga tcttggacat ttcggcaggt 568321 gacttgagaa gaggcattac attattacaa tccgcttcca agggggcgca atacttgggt 568381 gatggtaaaa acataacttc tacccaagtg gaagaattag ctggtgtggt acctcatgac 568441 attctaatag aaattgttga aaaagtcaaa agtggtgatt ttgatgagat taagaaatac 568501 gtcaatacgt ttatgaaaag cggttggtct gctgcgtcag tagttaacca actacatgaa 568561 tattacatca ccaacgataa ctttgatacg aacttcaaaa atcaaatatc ttggttgctg 568621 tttactacgg attccagatt aaacaacgga acgaacgagc acatccaatt attaaactta 568681 ttggttaaaa tatcccaact ctaatataca ggcatcttta tataattgaa tatagaggcg 568741 acataaagta agaataaaaa aaaaaaaatc tatccataat tcctcttatc ttctcagcac 568801 atcacctaaa agtcattttg atacaagtac tctttaaact gagcgaaggc tttaccacga 568861 tgagaaatag cattctttgc gtctttgctc atctctgcgt aagtcagtcc atgactatca 568921 aaaggttcaa aaattgaatc ccagccgaat gtagtgggtc cccggcttgg aacgatcttg 568981 cctcttgtaa taccttgaaa gaagtgatat tcaccccgag aatcagcaaa acaaatggtg 569041 gtaactgctt cagcgttttt attttcaaag ggttccaaca ttttcacaat tttttccaat 569101 cccatgctct ttaaaaacca ttttatataa gcacctggta gaccgttaaa ttcgtcaaat 569161 ctcaacgcag tgtcttccac aaacactggc ttacccttac ccaaggccgc aacagcttgc 569221 tttcccttag ctaacgcaat ggcattcaga tccgtgtcct gcaattcttc caggtctaag 569281 gcctcattga ttaagtggat ggttttgttg ttgttgtcga cctcttgagt caaaatcgac 569341 tgcacttcct ttaacttgtt ggcattgcca gtgacaaata caatttcgtt gttgctcatt 569401 ctgctatcgt tcgtttttag atatctctat gtgagtgttt cctatgcttt gaagaccagt 569461 gttgaaagct gaagctcgag agaacggttt cgaaaataaa taattttttt gctatttgat 569521 acatttgtat atataacgga aatggcgggt tttgaaaagt ataaaataca agattataca 569581 atgattattg ttactatcat tattgatgat gctgattctt ctaattagca gttggagcat 569641 attctagttc gttgctgttt tcgtaatcat acatatctag cgcaacgata caagattctc 569701 tgacgacatc gacttcatcg ttgaggtaag atttcaagac gtcgacaact tctggagaag 569761 caatggcacc caaggcttca gcagcttcat gcctaaccat tggagcttct tcctttctgc 569821 ccaaaacttc aatcaaactt gggacagcag ccggactacc tatttgaccg aagacgtagg 569881 cgatttcatg cttgaaaagg gaggattctg cactgaaacc agtggccaag gccaggattg 569941 cttcatcagt accgatatct ctcagtctga acatggctct gtatctttgg aacaaaggtt 570001 gcttaggatc attcaataag gcctgtagtt ctgggatggt agcatccttt tctaatggta 570061 gaggtggggc tgggtcaata ctcgagtata gggattgttg caagttttcc ttatccttgg 570121 cacctccatg ggtccagttg attctgttaa tggccagttc acaggtttct ctcacagcaa 570181 cgtgtggatc ctccttagca gccttattta ggtcatccaa cgaatccttg tcacctaggg 570241 cacccaaagc ctcagcggct tcgtgtctca ccattggttc ttgattttga tctaacataa 570301 cgtgtcttaa agttggagca gcgtccaagt tcttggtttg acccaacacg taggccactt 570361 cgtgcttcaa caactcagac ttgtcattga cgaaggattc ggcaatgtat tcgatggcct 570421 ttttggcttc ctctggctta gtggcaaatt cttcagcaac agtctttaag ttgaacagag 570481 ctctaaatct gttggccaaa actgttttgc cggacttgtt gactaagatg tcccttagtt 570541 gctctagagt gcattcatcg acgttttctt ggaaatgttt ttcaaagtta gtagacatgt 570601 tttttttttt ctttcttgcg tggtatgtta gaaggactac agtttatcct aacctaaacc 570661 tagagctacc gtcaaatata cacgtgtatt cactggattt gccttatgta atttatatga 570721 taaaaacttt tcagctcatc gagaaaaatt ttctttcctc ccacgcagga tagagaaaaa 570781 aaaaaaattt tttttttttc ttgtttctca ctgcattcta cagggatttc tgtggaagga 570841 ttacctctat tgttcaaaag ataataaacg tgggagttta tctgacgttc gtctttgcaa 570901 ttccattgtc tttttttttc tctgcgggtc gaatgatcgc cgaaccaaag gactatacgt 570961 agttatttag tttctaatat acttcgcgat attttctgca gtctcgctac tggccgtttt 571021 ccctacttgt tgcatagctt cctgatatct cctttgtagg tctggagcag agttctcgtt 571081 gacctcacct tttgttcttt cttcgcctgg gaacgtgtat tctctctcaa cgccttcgtc 571141 ctcatcccta tccacaagac catcattggc atcctcttcg aggtcgctaa tggcatctat 571201 gctgtcgttg tcgctggctg cagcgctgct cttctcgttt aaccctagat ccttcatcag 571261 gccattcaat gatttttgct ttctcatctc ttcctttttc ttttttaggt tcaatgcttt 571321 ttcacgttct tgcttatagt attggtcgta ttcatcaact ttcttgtcta cgcattgcat 571381 aaattcgtcg aatccgtctc cggtaaaact ggaaacgccc acgacgtcta gctgggaata 571441 gaattcttca agcatcagtg acatagaatt gaccaatgag ctcatgtacc cggagcccag 571501 cccattgtca ccattcaagt cttgatcttc cttgattgct gcttggaaac tctcaaaatc 571561 cgtcatccat tccttagcaa aatctgcctt gcacacgtcg gtcttgttga aaacgacaat 571621 catgggaagt ttggtcttat acagaatgga gcaggcgtac agcatgttac tcatgaatgt 571681 agttggggat gagtttctag gcgtatccac gatatatgca atcactgtgg gaaagctgga 571741 ggcaaaagat tccgtgataa tggcacccga cgcactccac acaaaacatt cgatttggcc 571801 tggagtgtcg atgatgcagt tttggaactt gtccttcttc tgttccacca acctaataac 571861 ttgatcaatc ttggtgctga acaaattcaa actggtgaca atggcaccgt tcggacctag 571921 ctggtaattc tccatcactt tcttgtattt gattgagtct ctgatatcga tgtttgcacc 571981 ataggggact ctcaatactg caggatcaag attgattacg tatggtggcg ttttctctgc 572041 ccgcaagtgg gagtttaacc tttgcatgaa agttgtttta ccggatccgg ccataccaat 572101 acatatgatt gtgctgagac tcattcttgc tgtgtcgtta ttgcgttttg tagttgtttg 572161 tgtgcgctag atgctctcat tgtattcctt gttaaataga gcatcgcatt aaaatttttt 572221 tttttcactt tcgcgaagaa attgcttatg gagctatata gaaacggtaa tagcataggc 572281 ttctaacatt atagaatata tagaaataga gcacttacat attctttttg gccttatcac 572341 ggttagcgta gatcatggca gtaaaaggtt cttcccaacg aagagcgatc ttgtacatga 572401 agtaaactac ggcagaaaca accagccccg caggctttcc tttgtaaagg gctatgccca 572461 agaaggacaa agtggaaccc tggtacatgg ggttgttgga aacgttgaag gggaagccgg 572521 tgactctctc atccatcagg atgccgaaat agtcacccaa gtacgtccct gtgataccca 572581 gcttgtacat ggaactcaaa acaagcactt gccccaaacc aaagagagcc acacccagct 572641 tggtccagtt ctcgcccgtg atcagagaac acgtaggctg ttcacgcaat gcagactcgt 572701 acaccatgtc tctgacgata cctagcgaaa atatggtcgc cgccaacatg taacagccct 572761 ttctggcccc accacacatc ttggtgagag aatgcttgtg gtattccatt cttgcaacga 572821 tgttccaaaa gataggattg aacatcgtgc acacaatggc cagctggaac ttggaagact 572881 gtaaatcgac actgtggatg agttgctgga tgatctcttg gactgactcc ttcatcgctt 572941 gacttgcgct attcttgttg tcttcaattg ctgtttatgg ctctgtccaa gaacgttcat 573001 gttcttcata tgtgttctct tataaagacc ccttatccag tggtcattgc agtggcagtg 573061 gacagaaacc aacgatgcat gtgtgggttt gcatatgaag attgaaaagg cttctcatat 573121 ttcacaaccg gtgcaacttt ccacatgcac tctcattgac acctaccctg gtcatcaagg 573181 aagcatgaac aacaaggaag tcgaattata cggcggcgcc atcactactg tcgtcccacc 573241 tgggtttata gacgcttcta ctctaagaga agtccccgat acacaggagg tgtacgtcaa 573301 ttcccgtcgc gatgaagaag aattcgaaga tggactagcc accaatgaaa gcattatcgt 573361 ggatctcttg gagacggtcg acaagagcga tctgaaggag gcttggcagt tccacgtgga 573421 agacctgacg gagttgaacg ggaccaccaa atgggaagct ttacaagaag acactgttca 573481 gcaaggaacc aagttcaccg gactcgttat ggaagtagca aataagtggg gaaaaccaga 573541 tctggcacag accgttgtca tcggcgtagc gttgatcaga ttaacccagt ttgacacgga 573601 tgtggtcatc tccattaatg tacctttgac aaaggaggag gcgtcgcaag caagcaacaa 573661 agagttgcct gcaagatgtc atgctgttta ccaattgttg caagaaatgg tacggaagtt 573721 tcacgttgtg gacacgtcgc tgtttgctta atctttcaaa ttttaacctt atgtttatat 573781 taccttttta tttctactat atagcgtatt acatgttttt tccgataagt ataacgaaat 573841 ttcccagcag cgaagaaagt gaaaaaataa cagtgaccat aatgaacatt cctctctttc 573901 cattttgcac gtattcttgc agagaagagg cactctactc ggaagacagc agatagatat 573961 atagactgta gcggttaacg atggccaaaa caacaaaaag agcctccagt ttcaggaggt 574021 tgatgatatt cgccataata gccctcatct cattagcatt tggagttaga tacctatttc 574081 acaattctaa tgctactgat ttacaaaaaa ttctgcagaa cttgcccaaa gagatttccc 574141 aaagcattaa tagtgccaac aatattcaga gttcggattc tgatctagtt caacattttg 574201 agagtttggc tcaggagatc agacaccaac aggaagttca agcaaagcaa tttgataaac 574261 aacgtaagat cctggaaaaa aaaatccaag acttgaaaca aacacctccg gaggccaccc 574321 taagagaacg catagctatg actttcccct acgattccca tgtcaagttc ccagcattta 574381 tttggcaaac ttggtccaat gatgaaggtc ccgagcgtgt tcaagatata aagggcatgt 574441 gggaaagcaa gaatccgggc tttgcgcacg aagtgttgaa ccatgacgtg ataaacgcac 574501 tagtacacca ctacttctac tccataccgg aaatcctaga gacttacgaa gctctgccct 574561 ccatcatcct aaagatagat tttttcaaat acttaatact gttagttcat ggaggtgttt 574621 atgctgacat cgacacgttc cctgttcagc caattccaaa ctggattcct gaagagttgt 574681 cgccatccga cattgggttg atagttggag ttgaggaaga cgctcaaaga gctgactgga 574741 gaaccaagta tatcagaaga cttcagtttg gtacttggat tatacaagca aaacctggtc 574801 accctgtttt gagggaaatc atttctcgaa ttattgagac cactttacag agaaagaggg 574861 acgaccaact aaacgtcaat ctaaggaatg atctgaatat tatgagttgg acgggttctg 574921 ggttgtggac tgacactatt ttcacgtatt tcaatgactt tatgagaagt ggtgtcaggg 574981 agaaggttac atggaaatta ttccataacc taaatcaacc aaaattgcta agtgatgttc 575041 tggtctttcc aaaattctcc tttaactgtc caaaccaaat cgataatgac gatccacaca 575101 agaaattcta tttcattact catttggcat cacaattttg gaaaaatact ccaaaggtgg 575161 agcagaaata agtacttcta cgcagatata ataaggaact tttttgttaa tttttttttg 575221 ctgatcgata ttaatacttt ttaagaatga agaaaaaaaa aaaataatat accagatgta 575281 tttacttata tacaacactc actctttata tatatagaga aagaagaaat aagtgaggaa 575341 gccaaaagcg gactcattct tcctgtttga ttttcgcctc tttttccaac ctggcttcaa 575401 tttctcttaa ttccttttct ctttgcaaca gttcttgtct tttcaacagc agttcttgct 575461 gaactctctc ctcaaatgcc tttagtcgct cttcttctaa ccgtatttgc tcctcacgtg 575521 tcatgtaggt ttcgttattt tcgccagtgc tttgcccgtg catatcggat gctgggttga 575581 gaacatcgtt attaatatta ttactttgct tgaagggatt tgtgtttctc cttgttgtgg 575641 tggacgatga cgacgaacca ttcaattttg tcagatttgg acgtatggat tctgccgcga 575701 cagattcacc tgataatgcc tcggttctat atctttcata taatatctca tgtgtgtagt 575761 ttttcaagtc atgtaaatga gagatcaata acgcattcct taagataaca aaatcagaga 575821 tcgatgaatc ttccacgtcc agtatgcccc atggatactt tctgccacga attgtcccaa 575881 catcgccgcc catttcgtaa acttcattgg atccaataat agcaaaaggt agaagtgtac 575941 gtaggtacat attggtttcg taatcttcgt ctgatatttc atcttcatcg aaagggaaat 576001 tataaattgg caagttccat ctgtcgatat cctccatgat caatttttta ttcagtttca 576061 gttcatctct tgtcaaggaa tctgatttgc tgatcacagg gatgatgtta actaaggatc 576121 ccaactgtct gatgaattcc acatcaatct cttttaaacc gtggccagtt gggttgatta 576181 agtaaagaca acaatgaact ctgccgtcct taaatcttgg gtttcttctc acacgacttt 576241 cttccaataa gatttcatca tattggtggc gaatgtagtc ggaaatgatt tcgaaagatg 576301 gagaattgtc gagagaatca ccgaatcccg gagtatcgat gatattaagt tgaatcttga 576361 caccttcatc atcttctaat tcgaccgtct cctctctcaa ttgtaagtct atttctgtgg 576421 acgtatctgt gggtaacaag attgtcgtcg aagtgtctac aacttgctga ccgcacaaag 576481 tatttataaa agtcgatcta ccagatccgg actggcccac gatcatcaca gtgaaggtta 576541 tacctctttt caaatgcttt ctttttctta atgcagaaga tgcgtcaatt attccggaca 576601 tggctggtgg ttagcaactt taggccttgt gatgattgac tttctaaacg gctccagatc 576661 gggtcgccaa tacgtggtgt ctacctattt tacttttcga tcaaatactt ttttgtttat 576721 ttttctttat gttagaaggc ggaaaaataa agaatactgg cgatcctgca tggtcgggta 576781 acgacccacg agcattgtgt tgtgtaaata tagccatatt taagctatat ttatctgtat 576841 aacatatacg tgtccgtatg tgcccgacca aatatgttac tgcgatgaaa tggattgaga 576901 acgatgttta aatgttatgt tccatgttgt gttttccacc aaaaaaccgt gaaggacaat 576961 tcaatgagca aagggtttaa cggagctata acctgctttt gtagatgaaa aaatagaaaa 577021 ttcaaatata tatatatata tatatttata atagcatgtt aatttacaga tatttggact 577081 tttgcaaagt cagtaaatac atggaataag aatactagtg attgaataga gtacatttaa 577141 acagatttat ttatttcttt cctttgttga ctctttctta gaatatgaaa aaaaaaaggg 577201 gctccggtgg tgatgaggag agaatatata tgcatgtatc aatcaagacc atttctaatg 577261 accaccacca ccaatttcaa tggttggtgg gcaacccaaa gtgctcttta aagaaccata 577321 aataccaaat tgcaaggagg tcaaggtacc aaccatgacc aaacgagtag gcaacccagc 577381 aaaggaaccg aaaaatccta actgtttggc caactgagcc aacaaaccga ctgtggattg 577441 gccaggagcc ttcttagtct tgttgacctt ggacaacaga gtgtctgctg gctgggaaac 577501 aatggcagcg gccaaaccag cagtcaaacc ggaaagcaaa ttcaacaaag tagtggaagt 577561 agaggacaat ttttcttttg gaccggcgaa cccgtagtag aactcggagg cacgttcaaa 577621 gaccaagaat ttagcaatgt tgtaaggaat ttgcttgaac aaaattggag tgaacccact 577681 gtagaaagag ccgatacctt cttctttcaa aattctggaa aaccctccga cgagtccatt 577741 agcgaactgt ggttgggaga ccaatctgat tctagtggct tctaggggac acaaggcaat 577801 gtctgccaag aattcggcca tggcagcaga acccatgtaa acagagttct tgtagcgaga 577861 ggcggtatcg taacccaagt tgtcaatgaa gaacttcttg aacacttcgt aaccaccgaa 577921 cttgaaggca ccttggatag agtaacccaa caaagtagga ccaaacccgg tcaacaacgc 577981 accagcacct tctccggcga tgatttgctt gaaagagccg accataccct tgttgtacac 578041 ggtaggttcc agttggattc tcgtcttaac gacatcgatc gggaccatac tggagtgagt 578101 cgacccgcac cctatggcgc cggctagggc gaatttcatg tagtcagaga cagagtactg 578161 tggaatagca ggagcagcag acacagacat ggtgagatga gactttttga tctttgtagt 578221 tcttcttctt gcagatcact ctgttctttg cgatggttct tgtagataaa aagatcggga 578281 ggatggatcg cacttaaaaa tcttctcgaa acgggccgcg gccgggcatg ggacccgttc 578341 tcgacgctga ttggctaacg atggttgggc agagtctcag ctgctgcttg ctcacattcg 578401 acaaaagact agaggaaagc agtaccatgc tgcgatactg ttgcatcgca gcattccgct 578461 gtccaaaaac aatacctgtt gtattgtttg aggctggcag gcgcttgggt agaaacaaca 578521 cccgatactg gtgacagggc tatctataaa tattaaaact tgactccgca attcgtcgta 578581 aactgcctta accatcgtaa tggacgccgt gcaaatgctt cgacttttcc cagtagtcag 578641 gcattgcgcc agacacttgt gctgcttaat tgtcgtaatg aaaacatatc ggtagcggcc 578701 tttttttatt ttttttctct atgggctgac gctgtcactt ttcaacgtcg ctccgaggca 578761 aaaaagccac cgtcagaaat aattactgtc acacacacta gatgtccatg tatctttagc 578821 atatataaag cgaaaataaa agaaagagtc aacgccgata tgaacaacac ttccataacc 578881 ggaccacaag tactacatag aacaaaaatg agaccactac cagtgctaga aaaatactgt 578941 atctcgccac atcatgggtt tttggacgac cggttaccct tgaccagact gagcagcaag 579001 aaatatatga aatgggaaga aatcgttgct gacctgccct ctcttttgca agaggataac 579061 aaggtgcgga gcgtcatcga tgggctggat gtcttggact tggatgagac gatcttgggc 579121 gacgtcaggg agctcagaag agcatattcc attttggggt ttatggcgca cgcttatatt 579181 tgggccagcg gaactccccg ggatgtatta ccggagtgta ttgcaaggcc actgttggag 579241 acagcacata ttttgggtgt gccaccgtta gctacgtact cctcgttggt gttatggaac 579301 ttcaaagtga ccgacgagtg caagaaaacg gaaaccgggt gtttggactt ggaaaatatt 579361 acaacgataa acacatttac gggaaccgtt gacgaaagtt ggttttatct ggtcagcgtg 579421 cggtttgaaa aaatcggcag cgcttgttta aaccatgggt tgcagatatt gagagccatt 579481 agaagcggtg ataaaggaga cgctaacgtg atagacgggt tggagggctt ggctgcaacg 579541 atcgaaaggt tatcgaaagc cttgatggaa atggagctta agtgtgaacc caatgtattt 579601 tatttcaaga taagaccatt tttggccggg tggacgaata tgtcgcatat ggggttacca 579661 cagggtgtta ggtatggagc ggaaggacag tatcggatct tttctggcgg gtccaatgcg 579721 caaagctcgt tgatacagac actggacatc cttttgggtg tgaaacacac tgcgaatgct 579781 gcgcattctt cccaaggaga cagcaagatc aattatctgg acgaaatgaa aaaatacatg 579841 ccaagagaac atcgtgaatt tctttaccat ttggaatcgg tatgtaatat tcgcgaatac 579901 gtttctcgta acgcttctaa ccgtgcattg caagaggcct atggacgttg catttccatg 579961 ctgaaaatat ttagagataa ccacattcaa attgttacca agtacattat tttgccctcc 580021 aattcaaagc aacacggctc caataagccg aacgtactaa gtccaatcga gcccaatacc 580081 aaagcaagtg gttgtttagg gcataaagtt gcctcatcta agactatcgg aaccggtggt 580141 acaagattaa tgcccttctt aaagcagtgc agggacgaga ctgtcgccac tgcggacatt 580201 aaaaatgaag ataaaaattg acattataca ttttattaac gccccccctt tttttttttt 580261 ttttgttgat gcagaagcct cgcaacttaa agcttttcag ttgtttcttc ttggtcatat 580321 tttttataca tatatacata catatatgca tgtgctgtgt actacatgct gcctttcttc 580381 aatttttatg tatagacaag gaggccagaa agatattata aacaatgttt tttatgtgaa 580441 cttcgaagta ctttgaaaat caaccctccc atcttgcgag acggtcgcaa taaacagtga 580501 gggtctgttg gcaagctcaa tgatctttga atttacatcg ttagccactt gtttctctaa 580561 attgacaccg ttatcattca cgttgctctt cttaacgtgg cccttggacg ttagtttagt 580621 tagaatatta tctttggatg ttgtcatttc atgcgtttga atcaatattg ttcttggacc 580681 tttaatcttc ataaagtacg agtcgacacc ataaatgtat cttttttcgt actggttacg 580741 gatccaactg cgcattcttt tgaaaaattg aacagtatgt ccgtaagcag attttagcgt 580801 ttggttctta atgaatttag gtgccaccgt atcattactt gaatctccga cgtacgcgcc 580861 ttccacgtgt aactcttgtc tctccactga atttgcaata tccaattgac tttggccgtt 580921 gatggccaaa atgtttctgg aattaaccag aattttgtcg ctttcatcaa ttaactcaat 580981 tgaatatacc aacccacctc cacatactaa cacatttcct ctcccattca gaatttgaaa 581041 tttccgtggt agttgtgatt ttgatgagtt cgagactaaa gaccttgcag agggaaagat 581101 aggcgatttg atttccagac tggagttctg ttcaaatgcg ataattgaat ccttgccaaa 581161 tacattccaa tcctttgtcc cggtcaaatt cagtacggac aagcttcttg aagaatcgaa 581221 aggtcttctc gatgtttgaa agtttggggc agccagaatt tctaaaacgg aggatccaat 581281 aattctatga aacaatgaag atttgaatga acgaaattta atcaggtttg accaaaaatt 581341 cagccattta taggaaaggg ataaatggtt caaattgtga atggaaacta ggcaatcctt 581401 tttgatacaa attggaatat ctggttgaac agtgatagat gcaattttac cattttcgtc 581461 tactagcctg aaacgggaag tcgcaatatc cttgcttaag ttctcgatat atgtcctttc 581521 tttagttacg acattactct ccgtcttggc cgcttgtggg ctcaaaagag aaattgatct 581581 ctgccaaact cgagtattca cccttgggct tatcatgatg ggtggatatc cttttctgtg 581641 cttctgtttt gtttatctgt atccgtttat tcgccagcca ataaaatgac tgggagcacg 581701 ggacctttga aattttgccc ttgttagtaa atcgttataa aaatacttat atagatattt 581761 tatagaaaat gaaaaataaa agaaatagcc aatatgtagg tatatcgaac ttaaaggtca 581821 cctgtcgaaa tcatttcctt cttctctctt tttcttttca atcagatgtt ttagagcggt 581881 caagcaacgt aaataccaac gtgtgctatc gcattagtcg ttttgtgatt ggccatgctg 581941 ctgcttcacg tacgtagcac tacttaatga aaaaatacga tcattgttat tgaatgcaga 582001 atctgcatgg ctgtggtgtg acttggagaa ggtatcaaac ccttttatga tgttaccaga 582061 atagtgtgat tttgacccat gggctccccc atgacctgaa tggttgttat tactattgtg 582121 tgagaaatac tcggtctctt tatcatatat ctcttgttgt aagttgtcaa aggtatcttc 582181 ttgctctctt ctatcttgga gggacttttt tagttccgct ttcaatgctt cataactttt 582241 cagctcatca gtcattttct tctaggcgta ggttggtaac aaacggaaag atgatggaaa 582301 atggctgttc tctaaagatg tttatcttac gtatattctt tgctttcgtt gtggctttac 582361 acacctttaa tcattaattt aatggcatag tcggcaagtt gttgaaggac ctgggttaat 582421 cgcctacatg tgaggttttt ttaaaaatat caattacatt taaaaaagga aagcagtagt 582481 accaaaaatc gggcaaaaaa aatttaccta aataaaggaa tgcataaatg aagccgttta 582541 atctttgtat ttaatgagaa tattacatat gaaggtctct tgagaaagca tcaatagtgg 582601 acattagcta ccttttaaat aaatgaacgg gtatgtcacc catgggttca aactcttcat 582661 catcctcgtc ttcactgcgt acttcatcgt attcgtaacc caaattttct tttatgtaat 582721 agtgatcttt cttacttttc ctcttttcca aaaggtcatc gaattcgtcc tcttccatat 582781 tcatttgatt gaatttgtta agtattcttt gtaagaatgg tgtgttctcc ccagcagttg 582841 ccgtggtatt agcattcttc atagtattcc ttgggggtag caagggagga cccgatgttg 582901 gagttgattc tgaactacgg cttggagcaa tattttgcat acgttgtgac cgattaggcg 582961 gagggttcgg tttacgattg ggtagagtgt tatttatgtt gctattaaca ttattattgg 583021 gcttactaaa aaaatcgttt atactctttt ttcccttgag catatttggt gaattattta 583081 cgtccacaaa tgtctgttga attcttttgg taaaagtaga gaggtattca cttgggttct 583141 ggttacctaa tttctgttgt ccatttcggg gcagtgtatc tttgaactgt aactctaatt 583201 gttttaattc tttttgggcg acctctaatt tgaaactaag ttcattgatt tctctgtgtt 583261 ttgcagctaa tttatatatt aaatcttggt ctgttgaaat cggacttgcg tggtcgctca 583321 cgggtgactg atttgtcgta gatctttgcg gacttgatat aggtatagca agtcttttgg 583381 gctttaaagg tgtcgtaacc cttggtgatt ttgattcagg ctgcacttca tgttgttttt 583441 gatgcggctg ttgctgctgt ccttgggagt gtttatcgac aatcgacagc ttatgtaatt 583501 caattggttg actaattaca cgctggtctt ctgacattac tttagggcgt atgtatggat 583561 gtattttgta ttgcttttgg ctagttagta gtattcctca atcgtattgt ttttgatttt 583621 gaaaaagcta acgataaagg tcaggaaaaa aaaagaaaat tgtatgtaaa ggaatgtctg 583681 gagagagtta cacaggaaca gaaaggtcca gcaacggttt ctacaaccaa tcatggatgt 583741 tgatatagga tgttattttg aagagaaacg ctatgacgac aaactgttag acttcatcag 583801 atatgacgtt aaaacaccta aaaagactaa atatatacta caaaggccta cggcgacaga 583861 tgaagagagt gtacgattac aaaggtttta ccaattagga gtagatctaa aattgaagta 583921 ttccaagcgg aggtcattga agaagcaagg gcggatcaag aatgctactg aggaattgct 583981 gcgattagcc aatgaacagt tgaaactttt caacagaata gtagaaagag aaaccaattg 584041 gataatttat ccgctgtggg taatggctaa acaattaatt cgtctggcaa acgaatctag 584101 tgaacttaat aaagactcaa ttgaggaatg tggacgcact atccatagaa gctttactat 584161 atgcctcaat gataggaacc caagattgaa tgaaaataaa aaaatcgggt gttatatgtt 584221 tgctaatcta gagttttcca tctaccatcg gttaagtaat aaagatatga ttaaaaattt 584281 agtgaaagtc ctcgagagca gagtgaacgc ccgggatata ccaccgttga ataaaagcct 584341 ggcaatggaa cataagtctc aagtggtgtt gtataattat tatctaggtc aatactacgg 584401 atgtctggaa aacgatcacg aacgcgggtt cttccattta aatgaagcat tattgcaatg 584461 tccaatgcta tatgtggaat ctaccggcaa gttcgtctta cagggccaaa tggaaaagat 584521 aatgatactg ctggttccgc ttgctctttt aactaaaagg ttgtaccctc actgggatca 584581 tccagtaatc gccggagtaa ttactaggag taagcgctta agtcaagttt atccgacatt 584641 agtgcgtagc gtaatctcag ggaacctgtc actgtacgag gctaccgcag caagccatga 584701 aagatttttc ctttcgcaag gattgcatgt cgtcatcaca ttacttcgag aggtggtctt 584761 cactcggttg gtacaacgat gttggcaatg ggggaatgat cggaaaagta tcatgccctt 584821 gaaaattctt ctggcaacaa aacaacacga tagttctgcc aatgaggacg aagaggagca 584881 gttggatgcc ctagaatgcc gtctagcaag tgctatagca agtgggcttt tgcgtgctta 584941 tctttctcac tccaaccgct gcatcgtttt cagtaagaag gagccctttc cccatagcaa 585001 atgatagaaa aatagtcaat aattgaacga agaaaaaaaa aagaaagttt gttcataaaa 585061 gaatatcata ttatatatat atatagggtc gtatatatat cgtgcgtctt cttccttctc 585121 taagggtaaa attccttgta tttgttataa tagtagtaac tgccgagccc acccaaagct 585181 gtcaaaacga cagggacagg tttagtgaac ctggaaggca tgcctcttat gacaccagca 585241 ccaagtagta aggtcgatgc acccaatgcc atttcgagcc caccatctct attcatatgt 585301 agcaagtaac cggcaatccc atatacacta ccgaatacta agccagatac tagagatgga 585361 atggagccct tacggtagta tcccataagg ccaccggctg tagtcaaaag actcaatgta 585421 tatgctggat gttccatagt gtgatctgat gttcctttct ctcaaacttc gtttctgtct 585481 tgtctcccgc tgttacctaa taacttcatg tgatctgctc ccccttctcg ttaaatacca 585541 ccttttcatc aaccccgtag ggcgcgacac gtctaaaata ttaacctctg aatacttatt 585601 gggtcaaaat gaatgttgat aactttcctt tacaaaaaaa aaactaatag agtatatgca 585661 tttcggtagt gaaatattcg ttaatgctaa tatgctcagt agtgatccta gattaccagt 585721 tttactgcag ccatcgtaca attttggaac gagtataaag agagaaatta aaaacgacaa 585781 gaaatattcg tactagcttc tcttccggct tgatgacagt cttaatatca tctgcaactc 585841 ttgaaatctt gctttatagt caaaatttac gtacgctttt cactatataa tatgatttgt 585901 caatgtgatg agtgaatgtc tccctgttac ccggttttca tgttgatttt tgtttcaggc 585961 tctaaatgtt tgatgcaata tttaacaagg agaacagaaa tgttttgtga cagcacctgt 586021 caattttagg atagtagcaa tcgcaaacgt tctcaataat tctaagaatg acatcagttc 586081 aaaactctcc acgcttacaa caacctcagg aacagcaaca gcaacagcaa cagctttcct 586141 taaagataaa acaattgaag ttaaaaagaa tcaacgaact taacaataaa ctgaggaaag 586201 aactcagccg tgaaagaatt actgcttcaa atgcatgtct tacaataata aactatacct 586261 cgaatacaaa agattataca ttaccagaac tatggggcta ccccgtagca ggatcaaatc 586321 attttataga gggtttgaaa aatgctcaaa aaaatagcca aatgtcaaac tcaaatagtg 586381 tttgttgtac gcttatgtaa tgatagtaat agaatccaaa aaaaaaaaaa atatacatgc 586441 tttttcatat cctctctcac cctatctttt tttttcttct aattttggct ccgttcatat 586501 cttattcaaa attaattcag cggtaatctt atctttattg ttagacttcg cagaaatttc 586561 ctttagcttc gatgcagata gtttgatcaa gtcattttgt ttattacgtc ccagttcgcg 586621 agaaatgatg ttaaccaatg cccacccttt taggtatagt tcgctaagtt caacgctcct 586681 caaagcattc tttaatgcct tttccaagag ctcggtcttg gtttgtttct tgctacgtag 586741 agcctcataa tacagagtct cacttagcct accaaaacaa gcgtaattga atggtgtaat 586801 acataggacc tgttccaaac aataacaggc tttttcaaat tggcccattt cgaaataaat 586861 ctcgctggca taccaccaca attctgcatc aagcgggaat ttatctgtaa gagctaccac 586921 ttctttaaga acactttctt ggctcaagtt cttggaagtt gtcttgatag ctatcaattt 586981 ctttgcaata gagacataag taacgaagtc cgtttcatac tccagatcat cattcaacaa 587041 attttccaga tattcaatag cgcctttatc atttccgttt atctgcaata aagtggcttt 587101 catgattacc attttatacg aattttcacc aagacgatct cttaatgtat tataaacaac 587161 ttgcgcatca acgtcttggt ttcggtacac caaaacatag aaaagcattt ccatcaagaa 587221 gaaatagttt ccttctgtta gtgcagagtc tccgcttttc atgtaaattt tcatttcatt 587281 ttctagttgc agtaattgtt ctggattaaa ttgagtatac gctttggtat tcataattgt 587341 caaaagcttt tctctaacca aatccttcaa cattgtttta tctactgctt tctataattt 587401 tctccgttcc aatgcgatcc aatgcctttc attcatacat agttatttat ttcattaacg 587461 atccaaatct ctttacttaa cttcactagt caacgcttct aacacatcac gcgatacgaa 587521 gattaacagt ttagtataat attgcaatac atacccattt cacacatcgg tcaaggtcat 587581 caagcacttt tagttatagt gtgtcctata gttctttcag attgattgag gtttcatatt 587641 agtgttgaaa gcctagctaa agttctctgg gcgtgcaaca ttcgaggaca catcggttgt 587701 ttatacctca tgggattatg gatggtcaaa tagataaaat ggagaagcga tatagcatga 587761 ccaaactgga gaataggtta aggactttcc aagatggtgt tgcacttgaa aaaaaaaagt 587821 taaagtggag ttttaaagtt attccgtatc aggcaatggc caagcttgga ttttactttg 587881 atccagtgat cgatcctaag acatctaaac tgaaaaaaga ctctgtaaga tgttgctatt 587941 gtcatcgtca aacatacaat gtgagagact gcagatccaa aagaaaagat gttcttgaga 588001 ctctaagcaa tataatgagg caacatctga ctgttactga taacaaacaa gtttgcctcc 588061 ttatttactt gcgcaataag ctattgacgg actatagctt ccatatgggg gtttcggact 588121 ggaaaaatga caagtacttc agcaatccag atgatgaaaa cgtgataaac ctaagaaaat 588181 ttacttttca agataactgg cctcacagtg gttctcaaaa tgaacatccg ctgggtatag 588241 aaaagatggt gaatgcagga ctcatgcgat acgactccag catagaaggc ttaggcgatc 588301 caagcatgga taaaacactt atgaacgata cctgttattg tatttattgc aaacagttgt 588361 tacaaggttg gtcaataaat gacgatccga tgagccgaca ttataaggtt tctcaaaatg 588421 ggaactgtta tttctttcag acacgtaatc gatttgagag aataaaaaat gacaatgaca 588481 gtatcacgaa aaattgcgaa gtctctccaa ctttaggcga aaatgggaaa agagaagtga 588541 tcaacacgaa aaccgcttct caaaggcagt gtcctttatt tgagtcacct ccatctagta 588601 ctggtcctca acttgacgat tataatgaga agacagatat atctgttatt caacataata 588661 taagtgtgct tgatggagca caaggcgaaa atgtaaaacg taatagtgtg gaagaaaaag 588721 aacaaatcaa catggaaaat ggaagcacta cattagaaga gggcaatata aatcgtgatg 588781 ttttagcaga taagaaagaa gttatttcga caccaactgc aaaagaaatc aaacgtccaa 588841 atgtccagct aacccaatca tcgtcaccta taaaaaagaa aagaaagttt aagagaatat 588901 cgcctagaaa aatctttgat gaggaagata gcgaacactc ccttaataat aattctgcca 588961 acggagacaa caaagataag gatttggtta tagattttac aagccatatc ataaaaaata 589021 gagatgtagg gagaaagaat gctattttag atgacagcac agatgaattc agtttcagta 589081 accaaggaca taacacattt gacataccta taccaacctc atcacatttg ctcaaaggta 589141 tagattcaga taatgacaat gttatacgag aagatgatac tggcataaat acagacacaa 589201 aaggagcgtc ttctaaacac gaaaaatttt ctgttaattc tgaagaagat ttaaatttca 589261 gtgaagtgaa actcacaggt agagacagta gtactaatat tcttataaga acgcaaattg 589321 tagatcagaa tttgggtgat atcgacagag ataaggtccc caatggtgga tccccagaag 589381 ttccaaagac acatgagtta attagagata actctgaaaa gagggaagca caaaacgggg 589441 aatttcgaca tcaaaaagat tcaactgtac ggcaatctcc agatatatta cattctaata 589501 aaagtggtga taattccagt aatattaccg caatacccaa agaggaacaa aggagaggca 589561 atagcaaaac atccagcatt cccgctgata ttcatcctaa accaaggaaa aacttgcaag 589621 aaccaagaag cctatcaata agtggaaaag ttgttccaac agaaagaaaa ttagataaca 589681 tcaatataga tctaaatttt tcggcgtccg atttttcacc atcatcacaa tctgagcaat 589741 catcaaaaag ctcaagcgtt atttcaacgc cggtagcgag ccctaaaatt aatctcacac 589801 gcagtttgca tgcagtcaaa gagctttctg gcctcaaaaa agaaactgac gatggtaagt 589861 attttactaa taagcaggaa actataaaaa tactggaaga tgtgtctgtg aagaatgaga 589921 ccccaaataa tgaaatgtta ctttttgaga ctggaacccc gatcgcatct caagaaaaca 589981 agtcaagaaa attatttgat gaagagtttt ctgggaagga attggatata cctatagatt 590041 catcaactgt agaaataaaa aaggttatta aacccgaatt tgagccagtc ccatcagttg 590101 caaggaattt ggtgtctgga acctcttcat atccacggaa ttcacgttta gaagaacaaa 590161 gaaaggaaac aagcacaagt ttggctgata attctaagaa aggaagttca tttaatgagg 590221 gcaacaacga aaaagaaccg aatgcagcag aatggtttaa aattgatgaa aatagacacc 590281 ttgtaaaaaa ttacttccat gatttgttaa aatatataaa taataatgat gctacgctag 590341 ctaatgacaa agacggtgat ctggcttttt tgattaagca aatgcctgca gaagagttgg 590401 acatgacatt caacaattgg gtgaacctaa aagtgcaatc tattaagcgc gaatttatag 590461 atgactgtga taagaaattg gacatattga gaagggatta ctatactgcc acaaatttta 590521 ttgaaacttt ggaagatgac aatcaattga tcgatattgc taagaaaatg ggcattttat 590581 agctaactaa tttgataaac aggctaaagg tttgtatttt ttgtagtttt gaaactgtgt 590641 atagaatgtt tcgccgcatc gcagatatct gcagggaact gttgacatag catcttctgt 590701 ggacgtgaca acgttacgta tattcgttga taccgcaagt ctatagcgta tacatgctaa 590761 ggcaaaaagt ttcaaagtga atgcattatg tatttatatg taaataagta agaaaagtgg 590821 gattttgaaa ataaaggtgt agtaggacag taagtattca atgaaataca attataacat 590881 atcttcatcg ggcgttcctg atgcttcatc catttgagaa tcaatggcag tgtcaggcat 590941 tgattcgtca attgtgttgt tgttattgtt cctaaccatg ttctgattac gaagtcccat 591001 ttggagattc ctcatctggt caggtgatat ttgcattcta ttgccaaact gacgccagaa 591061 atttggattt tctgtttcat tgtcatcatt accattgtta gtttcattgt tacttgtatc 591121 gtttgcccca gcatccgata caatattcac tatgttgttg gcgttccggt tggcgtcatt 591181 gtcattattg ttattccatg ctgatctttg gtgggctatt aatagttctc tttgtctggt 591241 taacaatgtt atgttatctt ttaaatatag tctcaaaaca acggtggaga gcttgtactt 591301 ctgaaccacc ataatgaatt tgtcaatgaa taaaagtcgc catattaaaa gccctttttg 591361 gtaatctatg ttgcccgatt cctgaaccgt tttttgtact aaacaaattt gtctgtttaa 591421 ttcaatcatt tgcatatagg tttgagtcat ttcatgaagt aaaaaaccag taaactgaaa 591481 ctgaactctt accaaactag caacattcac ctcgaaatca tcaatatgat catttaactc 591541 atggaatttt ctaacaatat gacacatttc actgttaatt tcccggttta caccaggtgc 591601 tacgacataa tcttgatcat cgtccacatc actaaatgga tcttcacaaa acgtcttgtt 591661 tacttgcaat aatagtgagt taacttcctc cgagctcatc ctaatgccat caaaagtatt 591721 gagataccaa ctgaatactt catctattcg ttcaaaattg atattctgga aaagaaaatc 591781 gttatttaga ccgttgattt gatttaatcc tgtagcagct ataattgcag cggaatcttg 591841 atttaaatca gttatgattc tcctaagagc atcttcaagt gtttcaccgt taaatatcaa 591901 attcttggat ctaatatatt ttgtcaaaac atcatttaca tcgacatgtg gtccaaaagc 591961 gggcgacgtt aaatttacta aataatggcg aagtttatga acacctttcc ctgaaaatac 592021 gcagaatatt tgacgttgat tttcactaaa gtctgagggt gcaggcctgc aatacatcgt 592081 tatatcgggg cgtaaaaatg acggaacagc agtcaaagac aaatgtgaga gccttgggca 592141 agacattaga agctcatata tcggatatat tgttaaatta gaacagtaag ataaatgtac 592201 cctttctaaa gtatcatttc ggcctcgcaa ggaaaccata ttcaacaaac cctcgtcagt 592261 catttgcgta catttgacaa ggccaattct ctttaatttt ggtaagtctg ctagttcata 592321 aagagttcta ttggttaaat tcgtacagca cgcaaagtcc acatactgta ttcttgtaca 592381 tgaatgaaag agtgctctta ccccgttatc agttatattg aaacagtgcc caaaatgcac 592441 tgtttgcaag tttttgccca gcttcgataa ttggaacaac gatgcatctg taattcggct 592501 acacttgcct agaaaaacat tacgtaattt aggggctaaa ttgactatac tttctatagt 592561 tttatctgta atattttcac atccagaaag atcaatcaat cttaaagagg gcatatcgtc 592621 aactacttta gaaagctcct ggaaaagatt atccgtaata ttcgtattat gagttattct 592681 gaattccctc agctgaacta acctagtgag gagttttaac aaactagaat cagtgacatt 592741 tggacttaat gttatatcga cctctacaag caaagggcat ttgttggcta atagttctac 592801 taattcgtca ttcatgttat tgtttgctgt gatttttatt cttttcaaca tcggggaatg 592861 gactatgaaa ttccgcagtg aatcgaatgt tacattcctt gcctgaggaa cataaaagcc 592921 ctgtactctg ggacaatatg tcgctaaggt atcaaatacg tcatcggaaa cgtctcttat 592981 tccagtgata tccacacttt ggagaaattt acatcctctc aaaacagccg atattggaac 593041 actggttata tgcttgcaaa atactaaagt tagtcgctcc aaattcttac atccgacaaa 593101 atagttaagc tctgtatcgt gcatgtagtc accaacaaat gaaaaattta atcttttgat 593161 cattaaacga tagttgaata cagtttcttc agaagttaac ttcatagtcc ttaaaaacaa 593221 gtctaattga ctctttttgt tgatgtgcgg tctgtaataa agtatcttca caattatttc 593281 agcccagagt ttggaaacgg taaggaattt tacaatatca tatttttggt taagtttatc 593341 taatattaag tgtaatattt ccgagggtag catgtttagg gcaaacacag gtgatcttcg 593401 ggtgacactc gtacatatgt tttgatttga tggattcgaa agcacattat ttatgaactg 593461 ccttgaatat ctcgaaagat cttgtagccc ttctttcaag tcagatgatt cagtagtatc 593521 tatggagttt atccaaatga tgaaattatc tgttggattt tccacttgtt gacctcttag 593581 cttggaatgg cagtatgcat ataatgactt tttgtactct tctataattg ttaatatttt 593641 tagccttaaa tttctaattt ccatgttttc tgtctctagc gccctaagcc tcattctttg 593701 taatttatgc aaataactaa ttgcttgtgg ggagttatca atacgtagct cctttagttt 593761 aaggttgtct agctcaattt cgttcagtat tttttttcta cgtttctcta taacaaccag 593821 aaactcttgg atttttttgc ccactattag cttgaattcg tggatttgct tccgttcttc 593881 ctctggtagg ttcggtaaca atcgattaag ttgatctatt tgaacattga caccattcat 593941 aaggtttgtg ttcacagtgt ttatgtcaat cccgttcagc gcatttgttt gctgttgtgg 594001 ttgaaatgtc agcgaaaagt tttgatttag cggttgtccg ttgttggttg gcaaaagcgt 594061 ttcccgttga atactatcga acctaaagat attatttagc gttgcatccc taacctcact 594121 tgcatttctt tccgaagttg ccgtttctct agttcgtgat ggcatttgtg gtcttgtgct 594181 attattattg ttgttgttgt tgttgttgtt gttgttgtcg tcaaaatcac cgctactatt 594241 cagccacaat tgagggccca aatttggatg tatatcaggt gggtgcagcc tattgctgtc 594301 attgtggttg ttgttatcct gatccattat agaccttctt agtataaagg aaaccgcaaa 594361 actgtttagc ctcactacca atgataatta ttgtgccgaa atcaatgaga aatttcaaga 594421 tttcacgcag gtgtaagctt aaatgcaatg ccttaatttt tgggcttccc tgctagttgg 594481 acacaagtac gattttgata ttcaaaaacc gggcttctaa gagaacgatt aaatgaaaac 594541 gaattattgt gtaaaatcga aaaactggtg aagtatggac aaaagaaagt aacacacagg 594601 cacagttaaa tttggtgtta tgtattttgc cacgcctttt ttgataatca tatcactaaa 594661 tttgttaaaa ggcaaatttt aaaacaagtt cctttaccaa ggaaggtcca taggcgggta 594721 acctcagtag taatgaaagc ctagtaatga tgactataaa tgttcattaa cacatctggg 594781 taataaatga tgatattttt aaaaactgta taaaacttta tggatttatt taatcatgat 594841 taggtgtaga aaaaaaattt ggcgatatga tggcttgaaa aagacacgtc ttcccagtaa 594901 tgaaaatgcc caaattcttc attagctcgc tcatattcta ttaggatttg aaccataaaa 594961 ccgttggggg taaatgagat agttttgaat ggatgcaggt atgagaagaa aacggcgtgg 595021 tctcccaatg atgacggaaa taaaagaaaa catggggacg tcagtttgca gagtgtaaag 595081 tcagagtttc aaaaacggtg ttatcgtcgt tatagttcgt gttgttatta ttgttgttgt 595141 tgttcgtatg aggttgtgag gagccaacat tgtttactaa ttccatagta gtgttgttat 595201 ggttagttag gctcagttgt ggcaacgata aacgggttcc gttattaaag tttagcatat 595261 caaactggga acttaagtca tcgttgttca tagcatatcc attactggcg ttgcctgaaa 595321 agccgctgac agggaagacg ccaggataac taaaatagcc cattgaagaa ttagaattgg 595381 cattcaatgg ttggcccggg gataatgtag aggcagaaga accatttgta gtcgtggtgt 595441 tcattgtggt atgtttagat ccaccacttt taacgctaga aacagaaaga cctctcatgt 595501 gttgtccaga agtatcagga gtggcgaaca tgtgcgaaat gctgctgtta tgatgctgct 595561 gctgttgttg ttttgtcttg ttatgagtac tagagggtga tgccaacccg acttcttcca 595621 ataaacggcg gcttggttgg atttgagtag aatccgtcaa tacttttctg acttgtttaa 595681 tgatgtgggc tcttaagtca tcttctaata atggcattgc taaaacttta tggacaaagg 595741 ttgggccata atttgtttca cataaaagct ttgttaattc ctttggtggc gaagaatcgt 595801 gtgcgttcac gtttccaaat agggaatcta ggatgatttt tctagcgtta tcatcccctc 595861 tgtaattcaa gaccttcaaa atagtcaaag aagccaatct gtggccacat aactctacaa 595921 ttcttttcgt caatcttggt gccaagatag aatgtctgtt gggtaaaaca ctagtatcta 595981 aaaaccacgt tactaacaac gcaccattgc tattagtgct tagatattca gcatatgtaa 596041 cgatcattgc actcaaaact attgattgtt caggagttac aatgtcatgt gcctctaaac 596101 aagctctgac tgcccttgca ccatatctat tctgaacaat aacccaaaaa ttagctatta 596161 tactttcaaa aataaactgg ttccagggga atccaaattt caaaacgcac tgtatgacat 596221 aatttccgaa ttggtcattg attaatggag tacagtagtc cttgacccct tgcgtcactt 596281 gcatgatttg tctcggagta tgcgccatag tgatcatctt ctgacaagcc catgttccgt 596341 ttttgtgaac acccatagag gttaggtatt tgcttgtttt cctcagcatg atgtctttaa 596401 taatatcaga tgaatgttca aataattttt gaacgatagt gttacccaag taatctgaac 596461 tcaattcggg caattcgtca agcattgcaa tagccaactg ttcgatctct aagtcggaaa 596521 atgcgtttga atcgattgat tttcgcaatt cgcgtaattt tggtggatcg aactccctgc 596581 cagacaatgg ttctggtaaa ggtccaaagt tttgcgtatc ggaagtgcct ttgtgattca 596641 gcgatttttt tatcaacgaa ttgatttggt attcatcgga atttgcttca aaaagttcga 596701 tgatctctct taacaaatct tccttttcgt taacgttagg tggtggtaga gggaaaggac 596761 attgttcttt ttcatttgct gagttattgt tgtttccgtg catactattg ttattattat 596821 aaccatggag aacattgcta aaaccagcag aacccgaact atggttttgg tgctgcgatt 596881 gttgtgattg ctggttaaat acaggtatag aaacatttcc ttgttgttgg aaagtcacag 596941 ctccattgaa taactgctcc tgtaataaag gctgtggttg caaattgttg ttttctaaac 597001 ccaatggcaa gccttgagaa ttgagaagaa attgtggggg ttgttgatgc ataggtaaga 597061 ttttggcaaa tgaaatttta cttggtgctc caatcataga tacctccttg ccctgtaaac 597121 tatctaaggc ttttacggca ctttccacgg aagaaaattc aactaaagcc atgtttaaat 597181 tccttaaagt cctagcagat atgacttcac catatttgga gcatagggtt gccaaggaag 597241 tacttgttaa gtttatcgcg ttatttaatt gtggctgctg gtgctgtagg ggaaaaacgt 597301 tggaaataga aatggtattt gtgggtaaaa ggttcgatat ttggtttatt gatggtacag 597361 tggggtccat tgttacccaa ttgatggatt gcggatctat ttcatcagca atcaatggag 597421 attcctgtgt tggaatagta tagtgcgatg aaatactggc acgagcgggc tgttcgtaca 597481 gtggagcgtc ggtatatatg ctagacgcgt tggattgaga tctctgtctg gtatttgacc 597541 aaacagagtt tgggatagcc aagttattcg tattcatctt attatctgcc atttggcttc 597601 cactagtaga taccatgttg tcaaaatatg cagtttttgt cgaataatcg ttgagcgtgt 597661 ttgaattagt tgtattattg cttgtcgtag gttgcaattg ttgcaaaagg tgctgttgca 597721 tgggatcgtt cgcactagca tttgaagacc atattccgct cgaagtacga ggcttggggg 597781 cgattgatga aatggaagtt atctgagaag acattgtgtt gtttctcgtc ctcgagatct 597841 gatgtggcaa gttaaacgag tcgctagatc ctcggggggc aggaattaag aagttattac 597901 tcgagtcagg aaaatgcacc aatttttcca tgtcttgagg aggggttaaa ctgccaggtc 597961 tatccatagt tacaccgtct atagaacttt ccatcatctt actcctggaa gggctggccc 598021 ttggtgtctt ggacgccacc gtagattggg aactgttgtt gctagaggaa aactcagcac 598081 cgttctttcc gtgactattt ttcttcgaat ggtgtaactt ggcactgatg gagggcaaaa 598141 ggttactcaa tgtattagaa aattttcctg ctcgcgacct atatgatcca agcttttggg 598201 gttgttgctg cagttggcta ttactctctc cattgttctc gtattcttcc tcgtatattg 598261 ggatagtgat gccagggtca atcacctcgg ggatgttgga caagttgttg atgttcatct 598321 gcttactttt atccatctta agaaggaata aatagacgtt cacgctcttt ctcacacata 598381 cacacaaatc tctcgaagtg cctcttattg ttttaactat tcatctctat gcgccattgg 598441 tcatcctacg agaaacgccc ccctttgtcc caataattgt cggcgggtaa tttgtccaaa 598501 tgaaaaagag acattgtcgc gaggaacgaa tagatgaccc gatttggaaa aaggtaaaca 598561 acaatgaaat attcctcgag aaaacaataa tgtttattta tgcaaaggaa acacttagaa 598621 gggaacatct ccattcacta aacttcgttg gtttggtgta tatttctttg attcagtctg 598681 tgcaagaaga attttttagt tcattaaatt atataaaaac aaaagtacag aagcatgcac 598741 gacgcagaga gtaccgtaga ttctctactg aaggagatag acaatgaaat ggaacaaaca 598801 aagtctaata tcacgcaaaa tggttccgaa gatacaccac acaactggaa gcttccgctg 598861 caggaaatag gcgatgatac catggaaatg ttggtcaaac acaatactag gtcgaatgct 598921 acagaaaata gtagaggtcg atcaccttct aagatgtcta ccatctcaaa tgaaagcctt 598981 aatttgggtc tcttacgtgt aaattcggaa cttgaagagt ctccagccgc tgtgcatcag 599041 gaacggatta aaaactctgt tgccaacggg gcacttggtc atgccaattc tcccaaagtg 599101 cttaataatc tgaaaaatat ggcacaagat atagataaac tagcccgtga tgaggaaaag 599161 cccgtaaaac ttagcagctc tccccttaaa tttactttga aatcgactca accactgctg 599221 tcgtatccag aatcgcccat ccacagaagt tctattgaaa ttgaaacgaa ttacgatgac 599281 gaagatgaag aggaagaaga tgcatacaca tgtttaacac agtcacctca aatattacac 599341 tctccatcaa ggattccaat aactaacgca gtgtcgatta ataagctcaa tcttgatttc 599401 acattgaatc ccaacgaatc agacaaaagt ctagtatctg acacctcagt tgatagcaca 599461 ggacgagaac tagatacgaa aacaatccca gaattaccat tttgtatgtc atcaacgccc 599521 gaaatgacgc cagtcgatga gaaatgtaac cttccaagta aattgttgaa cactagtaac 599581 aattcacatt ctgattcaag atcgccaaca gcctctgtgg aggatttaaa catttcaacg 599641 aatctgccgg gtgctgattc cagccaaaat aatccagtca ctactgatgc ggatgcgctt 599701 attgaaaacg atgttgtgcg ggaccttcaa cagaatatgg aacatatcga tgatgctttt 599761 gatgagaaaa aagttcttga cgaaggttgc agcaatgagc ccgttacctt tttgggtgaa 599821 aatgacacta ggtccatagt atactctaat aaagggacca atgctaatgt tcaagaattt 599881 tcacaggaag attctctagc gcacagtgaa cccaaattca aagatcttaa tgctacatcg 599941 gatgacgtat ggaatgaaga caaagaaaca gacgcaaata tttcaacatc tacaaagtca 600001 gaggaaagct acattgctga ctataaagta acgagacaag aagactggga taccaaaaag 600061 cttcatcaag aaagtgaaca tgcaaatgaa caaccggcaa taattcctca aaaggattct 600121 tcagaagaaa cattcactga actaaataat gaaagtgaat tccaaaggaa ctttaaggat 600181 ggagaggaat accgaatcgt tcaacacgag gagagcctgt atggacaaag aacaaagagt 600241 ccagaagaaa atataataaa tggcagtgaa attggtgtcg accatggaga ggccgctgaa 600301 gtgaatgaac cattggcaaa aacttctgca gaagaacatg atctttcatc atcatgtgaa 600361 gatcagtcgg tgagcgaggc tcgtaataaa gacagaattg aagagaagga agttgaaact 600421 aaggatgaga acattgaaac cgagaaagat gaaagtgagt accataaagt cgaagaaaat 600481 gaagagccgg aacacgttcc cctcttacca cccctgccaa gatgggaaga aattcaattc 600541 aacgagccat ttatagatga aaatgatacc tccaatgatt ccatcgattt aaccagatcc 600601 atgaaaccat cagattacat ttctatatgg catatccaag aagaggaaat caaatccaat 600661 tcaccagaat ccattgccaa ctcccaattt tcacaacaat cctcgattac cactgcatct 600721 acggtcgatt ctaagaagga taatggatca acttcgttca aattcaaacc tagaatagtg 600781 agcaggagta ggatttacaa tccaaaaagc agagtatcct cattgaatta ctacgataat 600841 gaagattaca ttttaagcaa cagtgaatgg aatgcactcg accctatgag aagaaataca 600901 ctcatctcta aaaggattca agataacata agaactcaaa agggtcacgc tccacttatt 600961 aggccaagca tcatgaaact taatggcgaa gattctggtt ttcagaatca tttcttggag 601021 gtagaacaac cgcaagaaca cgaaaatatc ccattaagta cgcacctaag cgaacaagat 601081 atcacaacaa atgtaggcct cgatgaacag aaattaccaa ccaataccca ggacgaagct 601141 gaaatttcca ttcgggaaat agagagtgcg ggtgatatca cttttaatag gggcgattta 601201 ctatctttat cctttgatga ggaattgggt caggattttg ctaattttct agacgctttg 601261 gatcatgact ccacatcttt caatcatggg ccggatgatt catccagttt tcaaagagac 601321 agttcaaaga aaagcttcaa ttctctttgg gaaagcagtt acgaactaaa accgccacct 601381 tccataagaa agcaacctat tgcccccgac gtcctgcaaa aattattaga atcagatact 601441 aaagatgacg cagatttgga aaaaattaga gaagagcgta taactgaacc aaggactggt 601501 ttggggattg gaatgctgaa aacaccagtt aaggatgttt caattgcgct agctgcaagc 601561 attaaaggat atgaggcaag tttcagcgat actgactctc gtccagaggg catgaataat 601621 agtgatgcca tcactttgaa catgttcgac gatttcgaag aagataaaat gaccccttcc 601681 actccagttc gtagtataag tccaataaaa cggcatgtta gcagtccttt caaggtcgtg 601741 aaagctggaa acaaacaaga gaataatgaa ataaacatta aggctgaaga ggaaatagag 601801 ccaatgacgc agcaagaaac cgatggtttg aaacaagata ttcctccact gctagcgcag 601861 acaaaagata acgtcgaagc aaaagaagaa acgataactc aacttgaaga accacaagac 601921 gttgaacaag aatttccgga tatgggaaca ctttatttaa gtataaaggc tatttccacg 601981 cttgcattat atggaactaa gagtcataga gcaacatatg ctattgtttt tgacaatggg 602041 gaaaatgtcg ttcagacacc ctgggagtcg cttccgtatg acggtaacat caggatcaat 602101 aaggaatttg aattgcccat agattttaaa ggaaaagccg aaacatcctc cgcttcttct 602161 gaaagagata gctacaaaaa atgtgttatc acattaaaat gtaaatatga aaaacctcga 602221 catgaattgg tcgaaatagt agacaaggtg ccggtgggta agagtttttt tggaaagaca 602281 aagtataaat ttgaaaagaa gtatgtacag aaaaaaccta aacaagatga gtgggattat 602341 ctatttgcac aagacggttc atttgctcgt tgtgaaattg aaattaatga agagtttttg 602401 aaaaacgtgg catttaatac cagtcatatg cattacaata tgattaacaa gtggagtaga 602461 atcgcagaca aaattcacgg ctcaaaaagg ctgtacgagt taccacgcaa ggcgcctcac 602521 aaagtggctt cgttggatgt ggaagcatgt ttcttagaaa gaacttctgc ctttgaacaa 602581 tttcccaaac aattttcatt ggtcaataag attgtttcca aatacaagtt gcaacaaaat 602641 atctataaag aagggtattt attgcaggat ggtggtgatc tgaaaggaaa gatagaaaac 602701 aggtttttca aactgcacgg ctcgcaactt tctggttatc atgaaatctc tagaaaggct 602761 aagatcgata ttaatctgtt gaaagtcacg aaagtcctac gtaatgaaga catccaggcg 602821 gataatggag ggcaaaggaa ttttacagat tgggtactct ttaatgaatg cttccagcta 602881 gtatttgacg atggtgaaag aattactttc aacgcggaat gctctaatga ggaaaaaagt 602941 gattggtaca ataagctcca ggaagttgtt gagttgaatg ttttccatca accctgggtg 603001 aaaaagtatt gtgaaaagtt agctgaggag gaaaagactc gaacaaccgg tcataatttg 603061 aagcaagatt ttaattagaa ggtgattaat ggaatgaaaa cagcatataa tctgatgact 603121 gagaggtctt tagtttaaag attaattaaa tacacataat aagagtaaat acgtgaatca 603181 tggacgatat atttttattt caatttcaca gatccccatt catttcgaat tttgattttg 603241 attttgatta ggctgttggt tcatgggtgg catcatacct ggcatgggga atggtggaaa 603301 gctaccaaac ataggtaagg gtgggaagct tggatgcatt ggtggagcgg gagggtttgg 603361 tgttccagac atactattac ccatattact gttcagatta gacatatttg cattgtttac 603421 gttgttgttg ttatcaatta tattaccgag gtttgagtct gtatcattcg cggaattcaa 603481 cttcccttgc tgttggaggg ataataggcc cattaggatc ctcctaggat tataatcttg 603541 ttgtagtttt tcctgtctat gtaaatactc catccaggta aattcgttaa aaccgtaatt 603601 gaaataatca cttaagttgg cccccggttg cctccagggt ttctccttta atacttcagg 603661 atctattgtc gttatgccaa cactatcaaa gattccctct ttatccaggt ctatagaacc 603721 agtcattgct ttcggtacat ttccatcgct ctctgtagct tttacggtcg ttgccgttac 603781 accttgattt gcttctcctt ctgttattag tctttcatct gatgtctttg tgatggtatt 603841 ggatacatct gtagctacgc taattacgtc tttgcttgaa gatgtcgctg cggtagaata 603901 agaatcgagt agttttgcat ctaacctagt agggtcagga cccagactta tgataacctc 603961 taggtcagaa tcactatcgt catctgagga gtcagagtag atatcttcat cagaacgatc 604021 atctctggca gtagctggag tttcttccac gggagagtcg aatttttgcc ttttaactat 604081 atcaggatta ctggacgcac ctgcgtctgc ttcatcatct cttgatcgtt tagatgaagg 604141 tagtgctaat tcggagtcgg aaccatacaa gaacttgtcg tcttcgtctt cactggagct 604201 catttagaga aatgctaata attttagtgt aggcaaaagg aataagaatg caaagcacga 604261 tggtgcggtt taacaaagtg aatttggtga tgtactctct caagatttat gtcgcattat 604321 tcgctacgaa ggtttttcaa gattaaaacg aatctccttt cccatcgcga catacgataa 604381 ggctaataac gctacggtat tatgtcatgg agcttgagac attgaataca tatatatacc 604441 tatatataat atatatatat gcaaatacac aaattcttag caatttgagt gagacaatgg 604501 aaataaagaa atgagtgtga atggatatat tttgagggaa gggggaagat tgtagtactt 604561 ttcgagaatt aagaataggt tttactaaac ttgtaggata tttcttgaaa cctgaccttg 604621 tcataataat cttgatcatt agaactgctg aaggagtaag ccgcagcata tcttgacagt 604681 ttggagttca acttttttag gaattctaac tcttttgaat ttaatttttg tagtgatggc 604741 ggtggtgatt tttcaacgtc gaaggcaatt tctaatgggt aatagtagga gggcacctga 604801 ggttcatcta taaatggatc tgcctcatat acattatcgg aggcgttgtt attattgctg 604861 gtattattat agtaattaca attagtgctt ttatggttgc tatagtgacg attattaaag 604921 gaatgtatgt tatcagtatg tggtggaaac tgatcttgat attgggagta tgaatccgtg 604981 ttttttgaat ttattgattc atgaatattt gtgggttttg aataggtata attagtggta 605041 tatgggtaga agtcttgtgt gtatgggaat tcattgaatt caaaattttc ttggaatatt 605101 ttgatatctt tttgtgcatt tgtattagtt tcatatttta ttgtgtcact aatatcgata 605161 tcatctccat ttctgttgct cttttgaaag ttatcatggt tattgaatga tgagtggaac 605221 gtagatgcgg attcatcatt agaaaaaaga gatgataatg aagaggatct ggtactttca 605281 gagctctttt ttcctctttc aggaccagtt gccattgtgc agtccttcgt agttttcgtt 605341 tccttggaaa taggctgaga atcaatattt tccaaattca gaaactcttc attgaacaat 605401 atttgaggat taattaaatg aattggttgt gtatgaacca agttctgcag ctgagatgag 605461 gcaattttgt cagacttttc aaaatgccaa cttctagggg aaattgtaga tccaaaagaa 605521 aaacaaggac ggtcttcttg atcggtggtt gtgtcataat aaatgttagg ttgttgttgc 605581 tgttcaaaag gaaagaggaa gaaaccatct tctaaggcag cgtgaagttt tccatgcata 605641 tccgcttgca ttttgtttgt ggggagagga atagaaaagc ttttctttta ttattttttt 605701 cctttttcac cagtaatggg tgccagtagg aatttgtttc tctgtaggtg actaatgaca 605761 gtagtatatt atgcttttaa tctttaacaa tactactggt cgatttataa tatgataatg 605821 taaaataaat cgtaatagga tagtcgatgt ttgtatctac ttcacgaaac agttatggta 605881 tacggtagtt taaatatctg aagaagcaaa aataccgaac tacaagggaa gcattttgag 605941 aaaaatatta agatcaaaag ataattaatt taccttaaat acataaaaga ggaaaagtaa 606001 tatacaaggt aaacaacagg caaggaacaa gatcaaaaac gtccgacccc aatttagtag 606061 taaattacag taagagaaaa aggtattggg gctgatacat attaattgtg cgttgttgtt 606121 gttgtttaat tttagattgg ctattatgag tacacacaaa acgttgtaaa cgcaatcacc 606181 catggataag cgctcccttt aaaatgcact acgaaatcat tgatctacta actttaaacc 606241 ggacttaaac catcaaaggg tgctctagat ctcatcgatg tattctgatg cagccaaaat 606301 tgcgcaatca atcacgtttc ccgatataga aaactaattg gctgtgttac gtggctgggg 606361 gttctgtaat tcctttcttc cccggtgaat catcaagatt gggctaagcg cctttgatcc 606421 tttccctcga agacggaaat ggggccgcag gataaaaaat ggtgtgtctg taattccgat 606481 tttttgctta tgtaatcatg taactttctt ctagtccctt tgcagacatg catgacactt 606541 ccttacccga atagtgagtt agatctgtgt taggatgcag gatgggcagt tcaaaggctt 606601 ttcttatcgt atctttacct tttcctgtaa ctaagaaggt ttttgagtgc atgtaaaggc 606661 acataaatga aactttaatt ccctgcgtat ttaagaccca agaagccacc atgacgcttc 606721 cttgatgttg tatctacccc caatcctggc gccccctcct gcgggcacgc atgcgccttt 606781 gatccttccc ctcgaagacg aaaagtaaac aaagatacgc actttttttc tccaacgcag 606841 tattgaaggt accatcacat gcttactcac tttgcggctg ctataacacc gtggcagtgt 606901 aacgttttac cgtttgtcct ttgctaccgc attttaaagt ggtacaagat gttgagagaa 606961 aagatttcct gcagccatga ttaggagagg taatagcgga tgacatcaac gaataagctt 607021 tatccagcgg cttgtatagt tctgtgtaca caattactgc cgggctctct gagcatttgc 607081 gtttctcggg ctagcttcat tacttagtaa cttcaaatta atgaaatatt taattatcat 607141 gattccaaac aaaactactt taatttcaat cacatttttg ttatctgcct gaaacgatag 607201 ctgtacgggt acgttcttga taaataaaac tcagtgttta aaactctctt tttacatctg 607261 ttcgccgatg attgcttgct cggaggtact agtcatcgga attgaggaaa ttccttttct 607321 cctttgtttt ctctttatcc ccgcgtaaat acgcggaatg ccaataatca agtacacatt 607381 ctttctccaa gttggccaaa aaatagttca aattctttaa actaagcgct attaattatt 607441 attaattata taagtttgaa aatatcaatg caggacccta tttcttcacg agggtgtatc 607501 cagaaacggt ttcttatata gtgttggcgc tcactttttt cctacccacg tctatatatg 607561 caacgcctac ttgttttaat caacatcaca attttatgct tttgaggtac agcagttagc 607621 cgtacgtttt cggcagtcgc taaaaatgta agcgcggcat ttactgccat ttagtggact 607681 tcttgaggtt cttttgacat ccgcattctt gcagcaaata cacccccacc cttcttttat 607741 tgagaatatc tactgaacct ccgtgaggga atacattaat caaattactc caacaccata 607801 cgggccgtgg cggaaagaac agcatgatat agataatata tgatatgaat tgattttttt 607861 ttcttttttt cttgcggctg gtatggtatt gtaaggatga tagtgcattc tatgagtgat 607921 ttttgtgacg gtgacgtacg atctctatac ctttttagcc gcccatcttc tgcctttcat 607981 ttttatgcca accctccatc catacatcct ttttaaccca tacatatcat ttagattatt 608041 gttttttaat ttttttttta tcagatgttg ttcatcgcga aatttataat ctttcgattg 608101 aatcgcactt gtcgtgcata atgataaata ccttccggag agaaaactca gacccactgg 608161 gaagttccta cctgccgagt aagaccagct tgaaaaattt gaaatttcaa ctgagaatca 608221 gaatatatta ctgcccttcg tgttgtaggg ttattcatta actatatacg atattataaa 608281 cagcatagat aatcaaacaa aaaaatgtat gcatataata gaggaattgg atgactaaat 608341 gttcttatat tggagttagt ggagatgcgt ggtagatttg aattaaatag aaagtgctgg 608401 ggttgataaa ccacgaaata tcgcagttga ggagaatgat aagccaggat agatggtagc 608461 gcatttttgg ggcaatctca ctgtaggtcc accacaactc aatatgacta catcgaatca 608521 gttataaggc aagtttttag tttactaaca aatatttcca tcttattttt tttttttgca 608581 gggctaagag aacaaagaag gtcggtatca caggtaaata cggtgtccgt tatggttcat 608641 cattgagaag acaagttaag aagcttgaaa ttcaacaaca tgccagatat gactgttcct 608701 tctgtggtaa gaagactgtt aagagaggtg cagctggtat ttggacttgt tcctgttgta 608761 agaagaccgt tgccggtggt gcttatactg tttctactgc agctgccgct actgttagat 608821 ctaccatcag aagattaaga gaaatggttg aagcttaaac ttctttcatt cattttctct 608881 tggctttcac taggtatatc tattccataa cgactatgtt ttgtatttgt taatttacat 608941 aaaaccatat cagtacatca acgaactgta aaaaagaaac tttagcataa ttattgcgga 609001 tatttaaact cacttgcagg taagagcaaa aggcgattga tttccagtcc gcctcttgtc 609061 acgtgattta gtaagaaatt ttgacagcac cctcggttta atggaaaaga ggggcgtttt 609121 tcgatgaacc cgaggggaga ctagagaatc atctcggttg aatggagcat tattttttta 609181 gtagcgcccg cccggagaaa tggacgttgg cgaatgagcc atgaattatt aaccgcccat 609241 gtctaccaga taccacatcg tatgacagta ccagcctagt cccggtaaac cgcaaacgga 609301 ccttaattgt gacgaagggc ccaaatttga tgggtcggtg ttaatgatta gtcctcattg 609361 tcataataaa gtgtgatgat ggaggcaatg atgatatacg gtagtactac tgctcgaggt 609421 gctatctttt aaccaatcct ttgagattct tgtcgccacg gagttactac cttttacaaa 609481 ccgtaatgtc acattttgca tatatcttat gtataaatat atagttcact tactacttgt 609541 tctcgttttg ttaactttct tgttgtagtt cttcttgttc ttggcgtttc cccctttgtt 609601 ttctatctgc ttcataagta aagtgcaaag cattttggaa gatattatca attgagtcat 609661 tgaaagaaac ttggcatctt ccctattact aaaactaaga atacttgatt caagaaagaa 609721 gtttatatta gttttagccg taagataaca taacaaagaa gaagaaagaa aaatgtctca 609781 aaaaaagaag gcttcccatc cagccatcaa tctcatggct ggcggcacag caggtttatt 609841 tgaagcattg tgttgtcatc ctttagatac aattaaggtg agaatgcaaa tatacagacg 609901 ggtagctggt attgaacatg ttaaaccccc aggatttatt aaaactgggc gtaccattta 609961 tcaaaaagaa ggtttcttgg ctctgtataa aggtctaggt gctgtggtca tcggtattat 610021 acctaagatg gcaatccgtt tctcgtctta tgaattctat agaaccttat tggttaacaa 610081 ggaatcagga attgtgtcta ccggtaatac ttttgttgct ggtgttgggg ctggtatcac 610141 cgaagctgtt cttgtcgtga acccgatgga agttgtaaag attaggttac aagctcagca 610201 tttaactccg agtgagccaa atgctggtcc taaatataac aacgccattc atgcagccta 610261 cactattgtc aaagaagaag gtgtttctgc cttatataga ggcgtttcct taactgcggc 610321 aaggcaagca actaatcagg gtgctaactt cacagtttat tctaaactga aggagttttt 610381 gcagaattac catcagatgg atgtcctacc ttcatgggaa acttcttgca taggtttgat 610441 ttcgggtgct attgggccgt tttccaacgc tccattggat actataaaga caaggctgca 610501 aaaggataag tccatctcat tggaaaaaca gtccggtatg aagaaaatca taaccattgg 610561 tgctcaacta ctgaaagaag aaggttttag agctttgtac aagggtatta ccccaagagt 610621 gatgagggtg gctccaggtc aggctgtcac ctttaccgtt tatgaatatg taagggagca 610681 tttagaaaat ttgggtatat tcaagaagaa tgacacacca aagccaaagc cattaaagta 610741 gatgatgaac aatgggacta caaaatgaaa taaagaaaaa atagaaatag gctagaagat 610801 caattattaa tcgccctatt cttccttatt acctacacaa aataaagcag caacataaga 610861 aacaaaaaca aaatgaaaac aaaccaaata aatctatgta agcatactca tttcaatttg 610921 atattcatta cttgactttt ttgtccttat ttgaggctcc ataagcgcgc catttttccc 610981 tactcccttt tttcgtaaat agtaataatg tgctgaaaag aacaatgaag tagttatcat 611041 acatattccg tcgtgtcgat atgaggggag gtgtctcttt ctttcatccc ttgtcgcaac 611101 ctccaatata taagagcata agcaactgat cttactttag taattaactt agcataccta 611161 gcccgaagga agaaaaaaaa ttcacctcaa caacatggtt cctaagtttt acaaactttc 611221 aaacggcttc aaaatcccaa gcattgcttt gggaacctac gatattccaa gatcgcaaac 611281 agccgaaatt gtgtatgaag gtgtcaagtg cggctaccgt catttcgata ctgctgttct 611341 ttatggtaat gagaaggaag ttggcgatgg tatcattaaa tggttgaacg aagatccagg 611401 gaaccataaa cgtgaggaaa tcttctacac tactaaatta tggaattcgc aaaacggata 611461 taaaagagct aaagctgcca ttcggcaatg tttgaatgaa gtctcgggct tgcaatacat 611521 cgatcttctt ttgattcatt cgccactgga aggttctaaa ttaaggttgg aaacttggcg 611581 cgccatgcaa gaagcggttg atgaaggatt ggttaagtct ataggggttt ccaactatgg 611641 gaaaaagcac attgatgaac ttttgaactg gccagaactg aagcacaagc cagtggtcaa 611701 ccaaatcgag atatcacctt ggattatgag acaagaatta gcagattact gtaaatctaa 611761 aggtctcgtc gtcgaagcct ttgccccatt gtgtcacggc tacaaaatga ctaatccaga 611821 tttattaaaa gtttgcaaag aggtggaccg taatccaggt caagttttga ttcgttggtc 611881 tttacaacac ggttatttac cactaccgaa gactaaaact gtgaagaggt tagaaggtaa 611941 ccttgcagcc tacaactttg aactgtcaga cgaacagatg aaatttcttg atcatcctga 612001 tgcttatgag cctaccgatt gggaatgcac agacgcgcca taaaaagaaa atgcgaaccg 612061 tagaataacg tatatagaac atataattag tttacgtttc acaaagtatt aatattacat 612121 gtagcttttt caggactttc gatctaaatc aaagattaaa ggagctgcta gaggtagaaa 612181 aggaaatcat tgacttttct tgaagattta tgagcgggta actggagatg gaaattttca 612241 gaaaaattgt aaatggatgc gatgacttcg atgtgacgtt actagtctta ccattgtaaa 612301 aaccactatc ggtgccaaaa gataagcgca atcaactaag aaatttacca cgctctttgt 612361 attgtattta tctccaattt aatctttctt ttggtgtgaa aatttagcga aaatgtcatt 612421 ggtgaattcg ttaacacact acgaaatttt aagaattcca tcggatgcaa cacaagatga 612481 aatcaaaaag gcatatagga atcggttact aaatacgcac cccgataaac tttctaaaag 612541 catacatgat acggttagca acgtcacaat caataagatt caagatgctt ataaaatact 612601 atcgaatata aaaactcgtc gcgaatatga taggttgatc cttgaaaact ataaacgcca 612661 aggatttcat aattgtggtg atgggctgga tgaattttcc ttagacgatt tctcatttga 612721 tgaagataag ctggagttta tgatgaattg tcctcgctgt caatttgttg gtggttttca 612781 ttttagtgag agtttgttag atgaatgcat tgataatgta gacgctatgg aacggagtca 612841 ttctggttat caattattaa cccaatgtag cgcatgcagc ttatggctga aggttaattt 612901 tgacatcgag gaagagcaag aaggacaata atgaaaatgg gaggggaaat tgagcatatc 612961 agataaatct gtttatagaa ttattatttt acttcgtggg aaatcgaatg gtgtatataa 613021 aagaggttgt aaaattgacg aaataaatag tatttaggca actaaagata aaaaaatatt 613081 atttattttt attcgcggtg cgttgccaga ttttttttga catgcggaat tttggtaaaa 613141 agaaaaatgc agatatgaat agtaaacaaa ggaataaaaa gcctttcatg aagaagttcg 613201 tgttcgagat cttcttcctt ctttttcgct gtcgacgata gatatgaatg cttttgccat 613261 tgatttcaaa tccgtcatta agctaacatg acctgaagaa ctggcgattt tacaaacaac 613321 tggaaagcct ctctgttcag gcaataacca tttatggtga acaacaccgt cgcccggacc 613381 atagtaaaaa tcttcataat tcccatcttt tatatcttgt ataccgttca ctttagcacc 613441 tctaacagtg ggaaccttgt taccgtaaac catggccaat ggaggatatt ctttgttcgg 613501 gtcgtaatct aagctatcca aataattctt tgtacgtttt aaagttctcg ctaaatattc 613561 acagctatct tcataagatg tatggaagac ttcatcgaaa ggcacatccc ttggtacctg 613621 tttattattg ccggctacat tcctaacaac aggtgcattt aggacaaact tggtagttgc 613681 gtttagggta gctttaagcg aaagcgctga tttcgttttc cttggtaata attttgattt 613741 ttcgtgagct gattcctctc ttttctcatt gacgagaggt gacaagccaa gggttttcca 613801 aacatctgta tcaaaaaaat cgaaatcata cctctctaag gtaattttgt caacaaaaca 613861 tctaccatct aacggtagaa aatagaaact acttctcata aaaaagttgg tttctttagt 613921 gaaaatagtt ttattccaca tcacatcatc tccaaaccta ataggaccta aaatatttgg 613981 acattggctt ggggaaccca cgtaaataat acctcttatc aaatgagtac agtcttgcaa 614041 cactttatgt gcgaccaatc cgcccattga atgggcaatg atgtatattc ccttcttatt 614101 tttttgctta ttgtaaattt cctctagttt agtcgttaaa tgcttggcag atatgtccaa 614161 ggataatctc caatcatagc caaactgctg aacatttaaa ttaggatttg cgtctagcct 614221 ctttatcaac ctcttagaga tatcaacagg ccctatatgt gttagcattc catcagggac 614281 aatctccttc tgagttttaa gttcatcttc gtcattaggt ccgatcaata aatcgacttt 614341 cgtcatattc aaacctgcct ttaatgggat ccaaattcgc ttatgagtag tagcatccct 614401 tagcacacta cctcgatatc cacccattat aacgacatct ccttccaatt cattccatat 614461 agattctaaa cgcgaacggt aatatccgtc atgagttttg tcgaatgggt ctgctgttat 614521 ttgcttaatg gagttcttca aggcatccat ttccaaagat tctttaacag cccttaacct 614581 tgaattatca atgccccttt cgtatttaaa taattctatc tcttccaagg aagaaatgga 614641 ggttgatttt ttcagttttt gcttgatctc attctttctt agattctttt tgatgaactc 614701 atctggagtc ttgggaagca cagttttaat tatggctaat ggtgaacttg atcggaaatt 614761 tgtattacca aatggtaagg aaaaggagaa agttttatga gagctgtcat agttcccgtc 614821 atgcgaataa gaaataattt catcgagatc ttcatcatca gcgtcaagag aaatggcact 614881 cgcttgcttc tcttctaaat tatgatagtt attgggccca gttgtttcct tctttcttcc 614941 cctttgttca ctatcgctgt ctttttctac tttattgctt ataactcttg cacctccaat 615001 caaggtatcc actttctcca ttgtatccaa ttcaccttcg ctttcattta cggaaaaaaa 615061 gcttacatca ctaccactat cacttgaatc agaaagacat tgcttgttat atttatcatt 615121 atcggaaata agatcagtag ccggagttgc catcattgta atactcccca gttaacctct 615181 acaagttgat tcttttacgt atcaccaaaa taggcaggct attcttaccc agtcctttct 615241 ttttaagggc gtcatagagt tgtaagcatt ttttgagaat gcagtgatga gctattaact 615301 tctcaaaact tcctgacgtt ttattacccg gattgaagta ccttgtattc ttggagatgt 615361 ctgtggtcga gttaggaagt gtgaacatgc ctatcaacgc cccaaaaacc agtgcagata 615421 atgatctgga acaatttttc cgtgttttaa acttcctcag tagaagtatt tttatttagt 615481 cgactataaa ggtggaagtc catacttaag agatattaag ggtattttga tcaacaagta 615541 agtaacaatc gttataaaaa tacaatagca aaagtatgag cggagaaaat cgtgctgtgg 615601 tgccgattga atcaaaccct gaagttttta caaattttgc acataaatta ggtttaaaaa 615661 atgaatgggc gtatttcgat atctatagct taacagagcc agagttacta gcattcttac 615721 caaggccagt gaaggccatt gtgctgctat ttccgataaa cgaggataga aaatcgagta 615781 ccagtcaaca aattacaagt tcttatgatg ttatatggtt taagcaatca gtcaaaaatg 615841 cgtgcggatt gtatgcaatt cttcattctt tgagcaataa ccagtcattg ttggagcccg 615901 gctccgactt ggacaatttt ttaaaatctc aaagtgatac ttcaagctcg aagaataggt 615961 ttgatgatgt tactaccgac caattcgtct tgaatgtaat aaaagagaat gtacaaacat 616021 tttctactgg ccagtcagaa gcaccagaag caactgcaga tactaatcta cactatatca 616081 catatgtgga agagaacgga gggatatttg aactggatgg aaggaatttg agcggacccc 616141 tctatttggg aaagagtgac ccaactgcca ccgatttgat tgaacaggaa ttagttagag 616201 tgagagtcgc ctcatatatg gaaaatgcaa atgaagaaga tgtattaaac tttgctatgc 616261 taggattggg ccctaattgg gaataataat tgttttatta ctgcgtagtc aaatatgtat 616321 ttacagaatt cttttaaata tataattcac ctactcatca tagccaccgc caaaagaaag 616381 gaaacctcca gtttgtctgg aatgtctcga aaaataatcg aaatcgatgg acacagcgtt 616441 tgctaataac acggcccttt gatccaaagt tagtacttga gaacttagca tctcagtagg 616501 ataaatatta tcaaagcatc tctgcgaatc aaatctaaca acataaacac cagtatcggt 616561 aaacatttct cttcctaaac caacccaatt tctgtctaca ctcgccatta tcttaccatc 616621 agcatctgtt acaggaaaat caaatgataa gaaaggtgca tctatcttac caaattggtc 616681 aaaagtggat ccttctactc catctttctg gaataattcg taacgacgcc tccagagatg 616741 ccagttctga atggtctctc ctactgtcgt tccttcttta ccgtcgtgat agtgagtgga 616801 gtcactgcca ttatcaacat acgcggaagg aggtatgata gtctttatat gagaattgat 616861 gaacgaaaag ggccttttaa tcgtcattat tacatttccc caattatcaa agacatctac 616921 caaaaaagga cgatgtagac gataaaactg ccgcattatg gcctttgtta tagaaaaatc 616981 tctttccatc attgatgcta ttttgtttcc gttcacatcc attatggcat acctattagc 617041 ctgctcgaaa cctagaaaaa cgttcataaa ttctatttgc ctttcgataa taactgtcgg 617101 ttcattaagt atcgtagtag ctataggatc atgtactttt attatcccgc tattgctatt 617161 ttctttaaat gcttttactg atggcgcctt cgttatttgg ttcttttcac gaattactct 617221 cctaaatgga ccgtttctga ttactttacc agaagaaacc gttaatgttt tactcagtgt 617281 actgaaattt ctcatacatg atcggtaagt tagaaatatt gccgttctat gcatgtcggt 617341 gttatccttt atgtttgacc tttaatcttc ttttgttttg tcttttttca tttcgtactt 617401 ttcaaatcct tattgccggt aggcttacaa acttgaatga agtatataac gaagtcaatg 617461 aaacctctcc catactaggt tcggaacctg ttaaggggaa caagaccgcg cacttgttat 617521 gaaaattctt cctataacta tattgaaagc tatttttcca catcggcaga caaacgactg 617581 tccagactta gtaaagctct tggtcgattt tgtacattgc ctttccttta cagctccaag 617641 atattatata tatttttgac aaggtaatca attgccccac aaatcttcca tataaaaacc 617701 tatatatgct attaaccgaa tggcaattcc ctctatctca tatctcacct ctacagtaat 617761 ccttccgtgg tatctggtct atagaaatgg gtactgtttc atttaaacgt gttatcactt 617821 gatccaatgg ttaccatctg actttggcat caatcccttc ttaaaaagta accaatcaat 617881 gatatgcgat tgtttatgaa gtccattcaa caaacaatgg gagtttggcc gagtggttta 617941 aggcgtcaga tttaggtgga tttaacctct aaaatctctg atatcttcgg atgcaagggt 618001 tcgaatccct tagctctcat tattttttgt attttttttt ttcacttccc atctttccaa 618061 gaatcttagg agaggtgccg cagtactttt ttggactgag caagaagtat cgcaaagcat 618121 ggaaaagtaa gaagggtata gcaaaagtct tttcacaata agaggatatt ttgcaggcaa 618181 atttctgaag accacataat atcgtcttct tggcgcaact aagacgcaga gaaatgcttg 618241 ttttcaaaag gggtattcac gtagtaccta aactaccaaa ttctaaggcc ctactgcaaa 618301 atggagtgcc taatatactc agttcttcgg gattcaagac ggtgtggttc gactaccagc 618361 gatatctatg tgataagcta acgctggcga cagcgggaca gtctttggaa tcatattatc 618421 catttcacat attgctgaaa actgcaggaa atccattaca gtcaaacatc ttcaatttgg 618481 cgtcctctat ccataataac catttattcg tggagaacat tctaccttct gctgttgaac 618541 atggcactaa ctcgaacgcc gttgtgaaga cagagccttc taggcttttt ttatccaaaa 618601 tcaaagattc attcaacggc agcgattggg aagtagtgaa ggaggaaatg atttaccgtg 618661 ctgagaatga agtcttggga caaggctggt tatttctagt tgaaaacaat gagaaaaaac 618721 tcttcatatt aacgagcaat aataatggta cgccgtatta ttttcccagg aaccagtcat 618781 ttgatttaaa cagtgcgata tccatcgatg aatttgctac cttgaaacaa atgaaagaac 618841 tgataggaaa gtctactaag ttgaatggta aggttcaaga ctggaccatg cctataatct 618901 gtgtcaatct gtgggatcat gcttatttac atgattatgg cgttggtaac cggtccaaat 618961 acgtgaagaa tgttctagat aacttgaatt ggtcagtggt aaataatagg atattctctg 619021 gtatatcgaa gtaatgaaaa gaaaggaagc gatagcctct taccctcata tgtaattata 619081 aaggtatcgg gtagaagggg atctaccaaa atcttatata ctgtaaatag ttttatttta 619141 tcctctcgct cgtgttttaa acaaccttaa tggcaattac tttatcattt tcatctttca 619201 gcattgtggc cctatttcta tcgcataggg gcttcaaaca ataatagagc aagctttcgg 619261 gcattctatg gaactcccaa ttgactgttt catcaccttc actcaattcg tataacgtaa 619321 tgacttgatt cagttttcca gagtcttcga accactgtag tatcaaagaa gcccaactgt 619381 ctaagctctt ccataatata aaatatctcg tagtggtggt attgctgctt ctcctaccac 619441 tttggtcaat cggtaagcat ttgccttctt tggtcatttg cgaccaaatt tcatcaataa 619501 atacctgtga tacagatctt tggatgtcct cattattaaa aagatttttc gagatttttt 619561 ttgaatcgtc attatctgta cttccactat ctagttcgtt gtcattgatt acagtcccgt 619621 caacagacat gtaccaaatt ttcttggtct tgcaatattg tgatatgatg tctatccacg 619681 tacttatctg ttgtctcctt gttaaagaat tgggttgacg ggtatatagt ggagggaatg 619741 agtatactgg aggtaatgca gacataatac acttgctata ttagcgcaac aagaataatt 619801 ctgagtgatg ctttgaattc aaatggttta gttgagaaaa tgttaaagaa ataactggac 619861 aagcgaactg cctgcaaaaa tttttgacaa cctttctgat atgcttaact tttatgaatt 619921 aggtattttt cttaagggac aacaaatcca gaagaacgaa attatttgag gaaccagtta 619981 aaaaggttat ttaacgaaca ctattaatgc aaaaaaatct cttgtacatg ttcattactc 620041 tattcatggg gtgtaatcat ttgtaggcac aaaatgcaga ctcttcagta gaaaggagca 620101 agttcgatga acagtcctta gctaacgcaa atatctaaaa aaatattcat atgaagactc 620161 tttctatcta ctatagttta caaatataat actgtatata agaccattta ttggcttaaa 620221 agattttaac caagagcaat cctatggaac gttctgtccc acttcactca agtttttgaa 620281 agggtaaaaa ttaaaaaaat tatagaatta acagtaaaat gtgctacgtt ccaaaaaaaa 620341 aaaatatgca ctatagtata ttactacatg taatacttcg gtcaaataca ctgggagtaa 620401 gtgaaaatag agattgttat ctccattagt ttcttcacat tcaataacta ctttttccgt 620461 atgaggcgct tacctcatca aaatgaagaa aaaaaaaagt atataagcag cgtgattgtc 620521 cgatcgaaat ctttcatttc tcaccctctc tctctttaaa cagtcgccca cacgttccct 620581 cttttttttt ttcgattgtt ttagttcccc ccctgccttt tcttctttat cttgtccttt 620641 ttagtttatc acattttttt tgtttttgag tatttatctt gtatctaact gtctatctga 620701 ctaggaatca atttgtaaag ttctaaaaaa aaatttaaag gcggctattg aaaatgaaat 620761 acgttgttgt ttctggtggt gttatctcag gtattggtaa gggtgtttta gcgtcctcta 620821 cagggatgct actgaaaacc ctcggcctaa aggttacttc catcaagatt gacccatata 620881 tgaatattga cgccgggacg atgtctccct tggaacatgg tgagtgtttt gtacttgatg 620941 atggtgggga aacggacttg gatctcggta attacgagcg gtacctcggt attaccttaa 621001 gcagggacca caacatcacc accggtaaga tatactccca cgtaatttcc agagaaagga 621061 gaggtgatta tttaggtaag acagttcaaa ttgttcctca tttgactaac gcaattcagg 621121 attggattca acgtgtttca aaaattccag tggatgacac aggattagaa ccagacgtct 621181 gtatcatcga gttaggtggt acggtcggtg acattgagag tgcgcccttc gtggaagcat 621241 tacgacaatt tcagttcgaa gttggaagag agaatttcgc cctgatccat gtttcacttg 621301 tgcccgtcat tcatggtgaa cagaagacga aacccaccca agcagcaatc aaagatttaa 621361 ggtcattagg gcttattccc gatatgattg cctgcagatg cagcgaagaa cttaacagga 621421 gcactattga caagattgcc atgttttgcc atgtggggcc ggagcaagtg gtcaacgttc 621481 atgatgttaa ctccacgtac cacgttccct tattgctgct aaagcaacat atgatcgact 621541 acctccattc aaggttgaaa ttaggtgaag tgcctctaac cttggaagac aaggaaagag 621601 ggtctcaatt attgactaac tgggaaaaca tgaccaaaaa cctagatgat tctgatgatg 621661 ttgtcaagat tgctcttgtg ggaaaataca ctaatttgaa ggattcctac ctatctgtga 621721 ccaaatcctt agaacacgca agcatgaagt gccgtcgtca gctagaaatc ctctgggtag 621781 aggcaagtaa cctagagccc gaaactcaag aggtggacaa gaacaagttc cacgattcat 621841 ggaataagct cagttccgcc gacggaattt tggttcctgg tggatttggc acgagaggta 621901 ttgaaggtat gattcttgct gccaaatggg cccgtgaatc cggtgttccc tttcttggtg 621961 tctgtcttgg attacaagtt gccgctatcg agttcgcccg caatgtgata ggccgcccaa 622021 acagcagttc tacagaattt ttggacgaga cactactagc tcctgaagac caagtagtca 622081 tatacatgcc cgagatcgac aaggaacaca tgggtggcac gatgagattg ggtttgaggc 622141 ctaccatttt ccaaccgaac tcagaatgga gcaacataag gaagctttat ggtgaagtta 622201 atgaggtgca tgagagacat cgtcatcgct atgagataaa cccgaaaata gtgaatgata 622261 tggagtctcg tggctttatt tttgttggta aggacgagac gggccagcgt tgcgaaatat 622321 tcgaattgaa aggccatcca tactacgtgg gcactcaata ccatccagag tatacatcga 622381 aggtgctgga accatcaaga ccgttttggg ggcttgtggc cgcagcctcc ggcacacttg 622441 gtgaagtgat caaggacata aatctaagcg agggaaatga aaatgaatga attgatgcgc 622501 ttactactta cttacatacg gtttttattc aagtatatta tcattaacat tagttggtta 622561 gaccaatgac accacaggct ggtcttggac cggcattacc agtcttcaaa gattcttcag 622621 tgtcaccctt acctaagtca tcttggccgg cgtggataac gacgcttctg cctacaacgg 622681 aggtaggacc gataagcttg atcaaagagt ccttgaagga gcccttggcc acaccatttt 622741 cgtccgtctt tacgttaccc atgtcaccga catgtctgac ttcgtcagtt ggagcaccat 622801 gtgtcttctt gaaaggattg aagtgaggac cagcagagac acaaccattg gtggcatctc 622861 caaactcatg aatgtggaac ccacgttctg cgttaggact gttaccagcg atctcgtaag 622921 agacagtggt tggctcggat tcggaagcct gttcgaactt gacaacacca gagacaccgg 622981 catcaccctt taacactgcg actgcttgaa ccattataaa ttaattatgt tttatttgtt 623041 tgcgcgattg ctttcttgcc tgtttttccg caacatagtt acagctaaac atttgcccaa 623101 aaccatcttc ttatatatat atctgcgatg gcgagcccag cggaagggat gtccgcttac 623161 taattccgac acaccggttt aaccccccgg cgtgctgggg tgggtgcccc taagggagcg 623221 ggttctgtac ttccagtaag cggcatttgc gctgtcatcg ccttatcgaa cccgctactg 623281 agatcatgtc ctgagtgggt gagtcgcacg cccaatcggc tgcacttcag agatacttac 623341 gtccaatttc gcatcatgcc aatattacct gtggaagttg aaactttttt tgcagatgcc 623401 gataattttc acatggatga gtcgcagtgt cgtcgtacgt gatgagggca ggcttgaaaa 623461 ttattcttcg agcccaattc tctttactta taggcatgcc atgtctaatt aggtagtcat 623521 ctcagtttat cttgtgcagg gtagaaccaa agataacagc aaaagaaaga gcaagcaatt 623581 atgaccgcac cattggtagt attgggtaac ccacttttag atttccaagc cgacgtcacg 623641 gctgaatacc tggccaagta ttctctaaag gaaaacgacg caattttggt cgatgccaaa 623701 tcaggcgatg ctaagatggc tatttttgac gagctcttac agatgccaga aacaaagctt 623761 gttgcaggtg gtgctgctca aaacactgct agaggggcag catacgtttt gggcgccggc 623821 caggtggtgt acttcggttc cgtcggtaag gacaagttca gcgagagatt gcttaacgaa 623881 aacgaaaaag ctggtgtcaa gtctatgtac caagttcaaa atgatattgg taccggtaag 623941 tgtgccgcat taatcactgg ccataaccgg tccttggtca ctgacttggg tgctgccaat 624001 ttctttactc cagaccactt ggacaagcat tgggacttgg tcgaagcagc taagctcttc 624061 tacatcggtg gtttccactt gaccgtgtct ccagacgcta tcgttaagtt gggccaacat 624121 gctaaagaga acagcaaacc tttcgtgttg aactttagtg ctcctttcat tcctcatgtc 624181 ttcaaagacg cattggccag agttttgcct tatgctaccg tcatcatcgc taacgaatcg 624241 gaggccgaag ccttttgcga cgccttccaa ttagactgtg ccaacactga tttggaagct 624301 attgctcaaa gaattgtcaa ggactctcca gttgaaaaga ctgtcatctt cacccacggt 624361 gtcgaaccaa cagtggtcgt gtcctccaag ggtaccagca catatccagt caaacctttg 624421 gactcttcta agatcgtcga caccaacggt gctggtgacg ccttcgctgg tggctttatg 624481 gctgggttga ctaaaggtga agatttggaa acctctattg acatgggtca atggctagct 624541 gctttgtcta ttcaagaagt tggtccctct tacccttccg aaaaaatatc ttactctaaa 624601 tagattcttc ttacaatata atagaaataa aatatactct acgtgttccc tctagctttt 624661 cattcgtaga catgtttacc gcttgttctt aaaccaaata agccaccgtt accacaataa 624721 ggaaaagagg cgctataaag tacagcttca agaaaaaagg acaagcagcg ctaagaacaa 624781 aatactcgtt catcctctcc acatacggcc gtacacaagc aacaataaca caataatatg 624841 gactgggcaa tcaatgtcgc ccatccacga ttactttaca aggatcctaa actttcagta 624901 acgtttattg tgccgagctt atttcatatc attattgctt tcgtgttatt aggaatatgt 624961 gcatccgatt ttctttgccc caacgtggcc catatatcag atcccaacag ccttcgatcg 625021 aatggttctt tagtctcaaa aacggcgtcc catgcatctc atactggggc attaatggca 625081 gttctactat cttggtgtaa ctcttcgcct gacctatttt ccaacttaat gagctgggca 625141 acctctacga gagaaacaag gtcaacctca gtatcgctat caattggtga ggtgcttggc 625201 gcttgcggca ttatcctgtg cattgtagag ggctccattt ttattattat gtcaagaact 625261 cacattgaaa tctcgcaaat tcaaaaacta tccatcatga gagacttgtt attttcttta 625321 gctgccatgt gcgtaatgag ttacgtttcc cttatgaatc aggtcactgt gctgaattgc 625381 cttttgatgg cgttccttta tgccttttat ctagtcgtta agttaacttt caagcttaat 625441 cattctgcag aaaccccaga tgaaactgct gcggatacga gcctcagaga aaactccgtt 625501 tctccttttt tggatgactc tctgatggct tctggtttac taccaccaat acaacctggc 625561 tttgacatat ccaattctat aacacacggc attaagccta gtttgctatc tgctatggat 625621 ttcaatagtt tcttatcaat gcttgaaaac tcatctttgg aggaggatga ctcaaggaat 625681 gaaatggcag aattgaacac tctacgtagc atgacgccgg gacaacattg gtccgcctct 625741 gcaacagttg caggagaggc aacgagtgct ggaagacctt tcagtgagcc aacgaatgcg 625801 tttacggaat atagagattc tgaaagagca ataaatagtt ccccagcggt gttcgccccc 625861 taccgtgaca accctgatga tgaagagtct caagagcaag tattattgga gacaacaacg 625921 catggtcatt ttggtgcgca agaaatgcga aggttctcca aaaggtctct gggctggatt 625981 ataaaaattt tcataccaca tctctcaaat ttttcccaga aatccatctc agatgcgatc 626041 ttttccataa taactgttcc gtttttcatt attttcaaac tatcatgtcc tcaaccgcct 626101 tcagatattt tgagttatga tcccactttg aacagatact ctttaacaac gttacccata 626161 attttattat ttatccaatc aattactgca cccttcctcc tttgcagtat actttctgtg 626221 cttttgacat atcatctagg ctatctcgtt taccttttcc ctcttatatt agctatggcc 626281 ttaattttac tattgacggc ttttattaca aaggtaaatc tgcataacaa gtttactctg 626341 tcattagaca gctctaacat tttacaggaa aagctacaaa aaagaaaact cctcgaaagg 626401 cttaacacaa gcatccaaat aatttttcta gctatcggca taataaatat cataatttgg 626461 atatcacttt tagccaattc tcttattgag atgatggaaa tttaccaaaa aatattagga 626521 ttatcgaaag ctattttggg ccttaccatt ttcgcatggg gcaactcagt aggagacttg 626581 atctccaaca tatctatgtg caggctctac aaaacccaaa ctcactacca agacagagtt 626641 cgtttagcca caaaattttt tatgatatca tgcgcatctt gcttaggagg cgtaatgctg 626701 aattctatgg gtggaatagg ctttagtggg ctagtatcaa tgctttttat tggcgctttt 626761 aatgataacg aatggtggtt cctaagaaag gttaaattac aagaaacaag tcaattggat 626821 aatacattaa attacaaatt catagtttct tgcgtcttca ttatcctaca gattattctc 626881 ttgctgttat tcttcggagg gcctaacaat attaaacggc gcctcacaaa ggagatgaag 626941 ttagtcggaa tctctatgtg cggactatgg gcactagcca cgttgattaa tatacttcta 627001 gaactgttta gctaaagctt gcaagagtgc ctcccgaaaa atttgttttt gtgacattta 627061 tctggcgccg taacagatcc gcgcagaaca cagaacacca agaaaagaag tactatttaa 627121 tttcaagatt acttagactc cgtcattcaa atcgcccttt tattcaaaca aaaatgggcc 627181 atatattctt tctgtctcaa ccttcgtttc cttggatgaa ttattttgat tgagctccaa 627241 aaaaaaagtt gtagccagga actatccaaa acttcgattg agaaacccat aacaatgatg 627301 cctgccagac ttttcatact atatcttttt gtagtactca tgcctgttgt tcattgttcg 627361 tccaacctgc ccatcactcc atatatctat gagcgtctag tatattttat taaggcaagc 627421 tctatatcaa gctgcatatc tgacaactta cttcttgtta ataaaacctt caacgacgga 627481 ggttgtccac cacatattaa cttctgcaat gatgagataa ttaacccaac agcgggtcaa 627541 acagtggttg aattagttct taatgcaaaa aaaggtgaat taggctcggg ttatctggct 627601 gttgaccacg gaaaaaaggt tgttatttta gcatttagag gatccacaac aagacaagat 627661 tggtttagtg attttgaaat atatcctgtt aactattctc ccctttgcgt taaggaatat 627721 cgtaagctta tagaggaagg aaaaatcaga gaatgtgaag gttgtaaaat gcatagagga 627781 tttctaaggt tcacagaaac tctcgggatg gacgtcttta aaaaaatgga gtcgattctg 627841 gaaagctttc cggaatatag gatcgttgtc actgggcact ccttgggggc agcattagca 627901 agtttggctg ggattgaatt aaagataaga ggctttgatc cgttagtgct gacattcgca 627961 acaccaaaga tatttaacag tgaaatgaaa caatgggtag acgagttatt tgaaacagat 628021 gctatagaaa aggagtcaat tcttaaagat gaaattcaat ttcgtaaggg ctattttagg 628081 gttgtgcata caggtgatta tattcctatg gttccaccat tctatcatcc ggctggttta 628141 gagatgttta ttaacaaagt tggtctacct cagaatgcgg aagatattga ataccgtggt 628201 aaaaataaca ggttaacttt aaaggatgga tttcgagagg gtatgagcgg tttggttgaa 628261 gactggttac atgtctatga acatcgagcc tacttcattg acgtagtggg atgttctgga 628321 ctttaacatt cacccacttt tacgtttttg tctataacta gcatatataa taccgctcta 628381 gagttactct aaactaaatg cgaccactat tcttaactaa taattgttct ttttacaaat 628441 aactctttca aaacttctaa tcttttctct tacgttttcc atttatctgc tcttcttctg 628501 aaactctttt tcctgcattg gccctctctt tgttacatga aagaggtttt agggttggta 628561 atatttctgg ttgtaaactt cttgaataca cttgggtagc taactgctta ttccagttct 628621 cctggccact aatcccggct acgcttttgt tgaaatagta ttcttctaca gcatcatagc 628681 tatcatcaca catgtctact agtttccacg tatgtcttgg aggtactcta tcttgaccgt 628741 agatggaagc tttaaaattt tcatcccttg ggaaatattc ctcacgtgga attttttgag 628801 cgctgcatgg ctaaattcta ccgaatccaa tacgtatatc cactactcaa catgttgggg 628861 cacaagtgat tacacactta atatctctgt catagaagct actacagaga aattggttga 628921 cactagatta ttaacaacac tcgagaatgc aaccgcttgg attaactcaa actctattga 628981 tgaagacgaa gatgatatgc ctcatgccac taacgtagca gaccggcttg atgggttatc 629041 ccttagcaag cgcgtatata gcatctgtca ctacgaattt tagtgcggat tctctccgta 629101 gcgtaaacgt tctctataca tcatctaccc atgttgctcc acctagcaga acatttcaga 629161 aagaaagaag tccaagtaat ggccaacaac cagaaggaca gcttttttta tgaaggcccc 629221 ctactgcata ttcattaagc ttaagcttga tcggtgaaaa atgctataat ctacgtgtac 629281 tggtcacatt gttgcacatc tcaattaatc aacgctctat tattatacgg aagatataaa 629341 ggcatagtaa atacacttgc ctgaggtatt gattgatgaa ttattttcca cggcccatgc 629401 gttactcact tcgaaaatac atttgaattt tagtgataag ttttgcgatc tacttttgtt 629461 caagataata atactggggt agaatataca ctaagaagtc tctttgaaat taaaaatatc 629521 tctaaaaaaa tccattatat aatatacagt aatacaatta gaggcaggtt tttcttttgc 629581 acaatcaata tgctttgaaa ccaataaatt catcccagga acggacttct ggtggaacta 629641 taacgtcatg agattccaaa attttgatct tttctgcaat ttttgccttc aaacactttg 629701 caaataacaa agccgtttga ggttcattga acaatgggat agcaaaatca atagcattcc 629761 ttctcataat atagtcaaca tcgtcagtgc tctcagctct cttggaggct aaattgaaaa 629821 cagcttttat gtcatattct tgaaatagtt cacgcaattt tctcttatca ttctttggaa 629881 atttaatcaa agaaaccttt gcgttctttt ctttgatgtg ttcctgtaga tacgttttag 629941 tggtctcatt agttgtgtat attctgtaac caatagtggc cactatggaa gccacttggc 630001 ccaagtattc tcgagatgta tcacctccaa ataatatacc acttggaggt agtggtacat 630061 ggaagttcat ggtactttga atagcagtcc aatagctttc aattaaatct ctaccaaatg 630121 aagcaacttc accagttgat gccatttcaa cccctaagaa aggatctgca ccagccaacc 630181 ttgtaaagga aaattgagga actttagtag caacatagtc gtactttttg ttgagcatca 630241 aatcaacagg ttttggtaca atgtcaccgc ccaaaaatgc cttgacagca atttcaataa 630301 aattaacgcc taaaactttt gaaacgaatg gaaatgatct agaagctcta atgttacatt 630361 caatcacttt caatgtatgc tccccatcct tgatgatttg catattgaag gggccagtga 630421 tcttccaagc ttttgcgacc ttatcagcaa tgtcttttag ggcaatcttc acatcgtcag 630481 aaagatgttg tggcggtaag actaaagaag catcaccgga gtgcacaccc gcattttcaa 630541 catgctcgga aatggcatgt accaagacat taccattata agcaacggcg tccacatcaa 630601 tttcttgagc accttcaata aatttagaca tgacgactgg gtggtctgga gaaacgtcag 630661 atgccaaagt taatttagcc ttcagttcct cctcattatt aacaacactc attgccgcac 630721 cggaaagaac atatgaggga cgaatcaaca cagggtagtt aactttagaa gcaaataatt 630781 ttgcttcttc tactgatgtt aattcactcc attcaggttg gtcaacatca atagaatcca 630841 aaatagatga gaatttgtgt ctgttctcag ctctatcaat atcgtttgga ttggtaccca 630901 ttatattaca gccgttatcg taaagtttca aggcaatgtt ttgaggtaat tgaccaccga 630961 cagaaataat gcaaccctca gattgctcca actcataaat gtccatcact ctttcatacg 631021 ataattcttc aaagtataat ctatcaactt catcgaaatc tgtggaaact gtttctgggt 631081 tataatttat catgatagtt ttcttgcctt gatctcttaa tgtcttcgcg gtgttcacgg 631141 cacaccaatc aaattctaca gatgaaccaa tacgatagac accagagcct aaaaccagca 631201 taccattttc gttgaactcc acatcgttct ttgtagcatt gtaagtggta tacaaataat 631261 tggtttgtgc tggaaattct gcggccaaag tatcgattct cttgacaaaa gggattatac 631321 ctaacgtttt tcttaaactt ctgatttcca gttcgttaat gtttgtggag gcgtgtttat 631381 ttatagtaac cgcaatctgc ttatctgaaa accctaattt cttggctctc tgcaagagat 631441 ctttactcaa gtcacttaaa gatttaactg attcaagctc tttatagata ttaacaatgt 631501 tcatgcactt gtaaagaaac catttatcaa ttttactcaa ttcattaact ctctcaacag 631561 tatagttttc atggattaag gcctgaccaa tggcaaggac tcttctatca gttggagttc 631621 tcaaggcttc atcaagttga tcgccgaatt cagtagaacc ttggaatccc aataatgatg 631681 gatccacctg tcttaatgct ttttgaaagg cttcttcata gtttctacca atagccataa 631741 cttctccaac tgatttcata gaggaaccaa tggatctgtc cacgtattgg aacttagaaa 631801 gatcccactt aggtattttt gccacaatat aatccaaaga tggctcaaag ttagccactg 631861 tagtttttgt gattgggttt ggcaattctg gcaaagtata gcctagccca attttggcgg 631921 cagtgtatgc taagggataa ccagtggcct tagacgccaa tgcagaggaa cgagataaac 631981 gtgcgttcac ttcaataact ctatagtcta gcccatcagg ttgcaaagcg tattggacat 632041 tacattcacc aataacacca aggtgtctaa tgattttaat tgcggcggat cttaacatat 632101 gaaactcttc atctgatagg gtctgcgaag gagcaaaaac catagaatca ccagtatgaa 632161 caccaagtgg gtcgaaattt tccatattac atactgtaat acagttacca accctatctc 632221 tgaccacttc atattcaact tctttccaac ctttcaaaga tttttcaaca agaatttgtg 632281 gggccaacga caaggactgt gcggcaagtt ccttcatttc acttgcattg ttagcgaaac 632341 ctgagcctaa cccacccaaa gcgtatgcag atctgacaat aactgggtat ttgacccttt 632401 cagcagcctc caaagcttca tccacggttt cacaagcaaa tgattctgcg atgggaatgt 632461 tgatatcctt taacgcagat gcgaaaagat ccctatcttc agaagtgatc aaagttttga 632521 taggagtacc taaaactttg acgttgtatt tagccaaaac accagattca tccagagcca 632581 ccccacaatt tagacctgtt tgaccaccga aggttaaaag tatagcatcc ggcctttcaa 632641 gttcaatgat atatgtgatg tattctggtg taacgggcaa gtaataaatc ttgtccgcca 632701 gggaatgaga agtctggtta gtagcgatat ttgggttaac caatatagta aacttgttat 632761 cttccttcag agctttgata gcttgagaac cactgtaatc gaattcacca gcttgaccaa 632821 tagagagccc tcctgatcca atgacaagta cagaatttac tccttcaact aattgaggtt 632881 tgtagtcctc ggtagtaaaa gcagaattcg taggctctgt tgatgtataa atcgatgtca 632941 ttcttttctt cctgtctatg tactgtattg ctcttccttt atagaactaa ttttaactat 633001 agatgttagt ttttcgatgc ttaaacttaa atagcgcttc aaaaaagaga taaggcatac 633061 tatagaagac gtattagtaa ttatatatat acaaatagca tggcagaaat gcttatgacg 633121 gaaaaaaaaa gattggattt tctcgatgct tactcaaggt gacacaatcg ttacgacatg 633181 gaggttccta tctctgatat tcaaaagtta ttgccatctc atcaataaga gtcattcaca 633241 ataatctata gaatgccgca ggaaagaaga cagtggtgga tgagtcattt tctcaaccct 633301 agtttacaat ctgaatgttt aggggattta ctatttttaa ttaggacatt tgaatatttc 633361 tgatagggta aaatcacttt ttagggtttc tgattttcta ttttcctcat ttttcacaat 633421 aataacaatg ttgccattct tttatcacta ccctaaatgt accaaatatt agtaagaaaa 633481 gaaacattat aaagaaaagg aggttttaca agggtcactt ggtgagatta ggtcgtcgtt 633541 attattttta ttttgtgggc ggggtgtaat agtgctaaaa agagggaaaa gaaatagtat 633601 accattccgc aaagatggag tacatcaaga ttgccaaagt atctaatgta gtgctgcata 633661 gaagaggtac ggccacacaa ggtactttac atttgactac tcaccatttg atctttgagt 633721 caccacaatt gtcgacggaa ttttggtttc catatccttt gatctatgga gtgcataaaa 633781 acccgggtag tacattactg tccaagttga cttccactaa tcaaatccaa ttggagggaa 633841 cggattcaca gaattacaag ctttaccagg gtaaggatct atggtctttt gtaaatatca 633901 aggtaattgg gaaagattat gcggtattct cattggattt cggtggtgat ttacatctac 633961 aggcaagaaa ggtgtatgat tccatcttaa atttgacggt cctgtccaat atcacgcaac 634021 tatatgcatt tatttacata tccaacaatc tggaaaggaa actaccttca cccgatagct 634081 gggatatata tgacccaatt aaggaatttc gaaggcaggg cctcgacagt aaagatgaaa 634141 catgtccttg gaggctatcc acggtaaacg aacactatga attttgtcca acgtatccct 634201 caaaactttt tgtaccaaga tccacgtcag atatattatt gaagcatgct tcgaagttta 634261 gatcacagaa aagaattcct gttttaactt atcatcacaa ggcaacagat tgcaacattc 634321 ttaggtcatc tcaaccatta ccggggttga tcaatcagag gtccattcaa gatgaaaaat 634381 tagtttggga aagcttcaac tcattttgta ataaagatat tagaagaacg aaacatgtaa 634441 tagtagatgc cagacccaga acaaatgcat tagcacagat ggcgttgggt ggcgggacag 634501 aaaatatgga taattataat ttttttttag ctgataacaa tatgggtgtc gataaaagtc 634561 taaaactgcc cacagttaca cggttatttc ttggtataga taacattcat attgtttcca 634621 acacagctgc atacatgacg gaagttatct gccaaggtgg cgatttgaat ttaccactgg 634681 aacagaattt aattaggagt caaaaatttt ccaattggtt gaagttgaac actcttattt 634741 taaaatccgt tgatatgctt ttaaagtcca tcattttcaa tcattccaac gttttggttc 634801 attgttctga cggttgggac agaaccagtc aagttgtatc actattagaa atttgtttgg 634861 atcctttcta tagaactttt gaaggtttta tgatcctagt ggaaaaagat tggtgctctt 634921 ttggtcaccg gtttttggaa agaagtggtc atttaaactc tgatattaga tttcatgata 634981 acactatgca ttccaacttc aacgatgtgg ataccaatgg cgatgatctt gacataggtg 635041 ttaacactca agacgattat gctgaagatg atgaaggagg tgaagatgag acgaatttaa 635101 ttaatttgag tagaatttcc aaaaaattta acgaaaactt taaattgaac aagaaaagtc 635161 taaagttcgt ctccccagtt ttccaacaat ttttagactg tgtataccaa cttttgacgc 635221 aaaacccaga tctatttgaa ttcaacgaaa gatttttaag aagactagtt taccacttgt 635281 attcatgcca atatggaaca ttcctttcca atagcgagaa ggagaaattt caacagaatt 635341 tgccaaacaa gactaaaagt gtctgggact acttcagatc tagaagaaag cagttcataa 635401 atccaaattt catacagaga aaaagaagcg gcatgaatga gcacgatcaa aaccttgaag 635461 aggaagaaaa agtggagtgg atttcgccgg atctgaagaa agtccaatgg tggtggcagt 635521 tatatggaag aaaagattca gaaatgaatg atgaattacg ccataaacga gactcagtac 635581 ccatatcggt ggataaaaag agtaaagagc atagtaattc cgatggcggt aagggtttaa 635641 atttgtcaat ttttggattt gatatgttta atagaaagtg atctggttaa cggcaaagaa 635701 gacaaataag tgagttagta ttttgcatac aatgatagaa gtatagaaaa gttcaagcat 635761 ttctccgttg ttagtataca tatatatata ttaattttaa tgaataaggg tacatatatt 635821 atgagcataa cgagtggccg atcggcaaag gggcttacaa ttttacaaca ccagatttcc 635881 aactaacacc acaccactga gatattagta tagccaatcc tctcactgcc tccacagttt 635941 ccttatcaca accaatattc aaggcacctt tcaaatgccc acgcaattga ggattaacat 636001 cttgtggaac caaagaagca attatcacta aacttgtctc ttgcgcagat agtatctcat 636061 caaaggcaaa caaagggcca tatacatgga ccagtgtata ataccataag tctgggtacg 636121 aagagtttag attgtttacc acgcgggttg agactttgtt gtatattgaa ttccaatgcc 636181 gtaagccgtt ctgtatggta tgatctcttt cctggattgt cttgtcatgc ttccttctca 636241 tagaggtttc cgaaagggga gaactgtttc ccatggcagc ctcccacggg tctattgggt 636301 ctaagtgcgg tactaaaatg tccggagtag tttcctttag catagtcagg ccattgatcg 636361 ctcttggaag gccggccaga ggtcctgttt taagaataac ttctctaaat tttgctgtca 636421 attgcttttg gaaaaaagta ggttgttggt aattctcatt gatcaaagtt tttctcattg 636481 gtaattctga gcgcagtaag tcaatggttt gggaagctaa tgtgaatcta tacatgtgtg 636541 cattatcatt actcagtagc atggcatagt ggtataattt aggtatttcc tgtggctcat 636601 tacaaacact gaacgtggcg gccgcaacaa ggtaccatat attcttcagt ttagggtgaa 636661 attgtgataa ttgtatcagc ctttgtgcat ttagtatctg gttcattctt gaaatacttg 636721 caaaatatat atgtattttt tatgataaag taaaggaagt ttggcaagtg gagcctgcag 636781 tgtggcactt gtatatatgt atgtgtaagt cagtacacaa gtataagcat atatggttat 636841 gcttcgttga gtaattatta gtcacacatt tttttaggct ctttaggatc tgcatttttt 636901 ttttggcaag cacgaattga aggacagaaa aaagaaaaaa agtgatgaga ttgaaacaat 636961 aacaaggtaa acaagtaaat gggaagccaa taaacaaaaa aaaaaaaatt agagtagaaa 637021 gaaccgagaa tggttaactc acatggaata cggtatattc ggttgaagca ggtctttaat 637081 cgtgcattgg accaatcgat ttcgaaatta cagagttggg acaaggtcag ttcatgcttc 637141 ccgcaatatg tgaatagcaa gcagggcgct ataaacgtcg ccaattgtca gcgccaatta 637201 acggaattct ggacggagct ttgtcaacga gagtttaaag aaattatgga agaacgaaac 637261 gtcgagcaga aactaaatga gttggacgaa ctgattttgg aggctaaaga acgttacacg 637321 gatcgtgatc aagatgaagt aaacaaaggg cccgcgatcg atgagctctc cagcaaagag 637381 cttgtggaat gccatttata cagccaacgg atgcatgcca tacacgagat agacgagcgg 637441 cttgcgaaag tgaatgagat gaacgaccag ttagcccagg agttgaaaga cttagagacg 637501 caagtagagg tagagaaaaa cgaaattggc aagatgtacg atgagtacct gggctcccac 637561 acggaccaac cggccaacgt gctgctggta cagagcctca atgatatggt cttggaattg 637621 aaggaaaact attgattagt tgtataaatt tcataagtga cgtataagga acctgtttta 637681 tgtattcatt aagcgaggcg aaaagcgagg cgacatactt cttttcacat caactcgaac 637741 agagaaaaaa gtagacatag aaagaaccca aagaccacaa gagcaaacaa tggtacagct 637801 gagaagaacg tatgtatata tgttcgtggt aagctcgttg gtatgcacgt atcttaggca 637861 tcactaccaa caaagtgttt caagcgatca cgtcgactaa cgacaaagtt gctcactttg 637921 tcgtgttcat gtgggagtcg tggctgtttg taaagatgtt tgctgaggac atcgtgactt 637981 tccgcaagct acaggccaac aagtacgtgt taggggtgct gatctgttca ttatgcgcaa 638041 gtgtaacgag tgaattcgcc caaagcgtgg tttcgcgggg acaaagggtg ttcgatgtga 638101 aggatattat ttgtaatttc tggggcagtc tgcttggtgt gggcattgcc ttctaccagg 638161 accgataaaa agagattata cggaaaatca tataaatgtg tttatgtaca ggcaagttta 638221 cgtagactag attactttaa ttgaatatat gctctgtgag caatggctgt cttgtgaatc 638281 tggtccctct tttcaaaggc agacgaagtg cctttggcaa tggcagtgag ttcttctccc 638341 aaacgcacgg cgaagtcgct cgacactctt tggtttgcgc tttgtacgat ccagttccac 638401 gcgatcctat ttctttgcct cttgttcaga ggcacaggaa tgacagaagc cttggccacg 638461 cctgtgttga atgtcttggt catcatcagc ggagctagtt cgtcgagtga cttttccaaa 638521 gcctggatgg ggtcctgccg ggtctggcag tacaccagat ataaggccct ggacagaatg 638581 gtttgtgcct tttccttctt accgtggcgc atgatcatgt ttgtgatgtg atccagcgtt 638641 gcgttcttgc gtggaggaat gggcacggac ttcagtgcct cccattgtgc caactgctct 638701 gcagttggct ttatcttgga gcccgcctgt gaaccctgta agaggtctac tttggactgg 638761 cccggtggag ccagcgaggt ctctggcagg tattcttttg cagagaactc ttcccttagc 638821 tcgttgatcg cttcaagcca ctcgtcgacc cctttctctg ccgatggttc gctagctggt 638881 gttcgtactg acgactggaa acgagcaaca catgtcccac tttgccacag gagacgtggc 638941 ctgactaaca tatacctcct cgcacaatgc agcattatat tcacctcaga tccgtatcta 639001 tctatttttc ttctgaaaac gatagctgct gtcttttctg tacgtgtata atgtgcattg 639061 tatgtagtaa gctatttctc aagcaaatgt agattggagc caagacgaac atttaaagcc 639121 gtatagaact actttgtttc ttcttcagat gatcatttct catatatggt cacgtggctc 639181 gatgtttatc gctttatctt tttttttttt tttttttttg cttttcattt tggctctgct 639241 ctctgtatta gctcatcatt taacgcaaat gaccacgaga caataaaccg acgaggaatg 639301 tgctcatatg tctcgccaat acctctaaat aattgaccgc gcgattattt agtgtgacca 639361 gagcaaagta gctttgcgtc cgaccatgca accatggata tactcaaaaa tggcaatagt 639421 gtgcccctaa tacgtttgct ggccagtatc cctttctgaa ataagctaaa cccttgcaac 639481 caccaggggt gccgccgtcc taactttcca gcctggcagc gcgtcgagtc gccgaatgtt 639541 gcgggcgctg ccccgcccgc aacaccgcgc ccgccctgcc tcagcttaac cgaaaccaca 639601 cgggtctgcc atcttccata taccctggct cttctttcac aatgcccgct cacaacgcca 639661 actgcaaaag aagcccgccc ttagtcggtt ttccccactt tgatataacc cccccccccc 639721 cccccccgca tcaactggta atttaaccca aacaccacgg ggtcataatt taaaagcgaa 639781 aaaccttaaa gcgttctcga agaaatcttc ctgtagatga tgtcgtagca aacttatctt 639841 ttagagtgtt tgtgcttact gcattgtcag atcaaaattt acgtagccgc ccttttcaac 639901 ccctgtcgaa gagtagcata acagcagcgt agtgaacgtg catgttcaca aatacacgta 639961 caatattaat atacaatagt aaggtgatga acacacacac acacacacac acacacacac 640021 acacacacat atatatatat acaggagatc aagttagtgt gaggggacga ctactgagtt 640081 tgaagttctt taaagtgtta aagttatttt tcccctctcc cacctcgttg gcaacctctc 640141 acccaccgct tagcagcatg tctccgtaca tgaccatacc tcagcaatac ttatacataa 640201 gcaagatacg ttccaagctg tctcagtgcg cccttactcg acaccaccac agagaacttg 640261 atctacgaaa aatggtgggc cacgccaata tgctggacag gatcctcgac gaaatagacg 640321 aaatcgacag cgaggtagta ctgtgtgacg ctgccgatgg ttcttctact gcagaagctc 640381 attccgcttc cccagcatcc agcgactctt ctcctctcac taataacatc cggcccatta 640441 gcattatgtg attagcatgc attttcccct tttcctttct taagaacatt tttacgacgc 640501 ggatctgccc gtcatcgcat acgaatgttg aatcacgcca gaatcaccaa agaaaaaaac 640561 tcgttcagtt cctaggtttt atgagccagg aacaatagac ttttatcgca tattatttct 640621 atacgtgcac ttatatatgc acacatatgt ttatatacat atacatacat acgtgtttct 640681 tttcagcctg tgtttttgtc gggtccaaaa acatacaagg caacataata ttttgacata 640741 actcaacgca acataacagt ataaaacata gtttaataaa agagaaaaaa aaaacaatat 640801 ttttaagcta tcgctcttgc cgcaatgaac gccaactcta ccacgacagc aatcggcctc 640861 accagcccct tcgaaaagct gtccttcttc cctcattcgt ctaatttaat actggctcat 640921 ttgcatgaga tcatcttcag cttcgtcttc taccagctcg cattctccgt tgtcgcaccg 640981 ttcttgaata aagtggtctt tcgcaagcac tacaccacga tccgtgaccc actgctgaaa 641041 attgatttca atgtccacac cgtctcgatg atccaggctg tcgtctcgaa caccgtcctg 641101 ttgcccaccc tcacgacgcc aatgcattat aatgttgtca cctacacaga ttcgtacagt 641161 tcaatggtat cttccctcag cgcagggtac tttatctggg acttgactat gtgcgtgcgt 641221 tacttcaagc tttatggtct cgagttcacg ggccacgcca ttggctccgt atatgtgatg 641281 ctgttgtcct taagaccgtt ctgccaaccc tggatcggca ggttccttat ctacgaggcc 641341 tccactccct ttgtgaacat caattggttc atcatgcaat gtaacgccaa gagcaagaac 641401 tctatccctc tgtggtttaa tgtcgtcaat ggccttttgc tcatgactgt gtttttcgtc 641461 gtcaggattt gctggggctc catcgcatcc gctctcttat tcaggcagat gtggaaggta 641521 agagacgagt tacccaagtt ttctgctgtc acgatgatgt cgctgaacat tttcatgaac 641581 cttttgaacg tgctttggtt caagaagatg attagaatcg ccaagaaact tgcaaaacca 641641 gccccaacgt cgaagctaga ctaaacctac ctttttttct atcttcaaca acgaaacgcc 641701 ttacacacac acacacatac atctacatac atacatacaa atatacatat atgtaaactt 641761 gtatattcat tcctattaac caaaaagagg caattaaact tttccctctt tttctacgtc 641821 atttactcaa aaactctaat tccttcgtct ctgttctgcc attttctcca gaaaaaaatc 641881 gacgggaaat aaaaaaaaaa agacaacgaa caagagaaaa agttcgcgaa ttataaacca 641941 cttctataat taacaggaaa aggaaggaaa aaaaaggagg aaatagaaaa ctgcaggcct 642001 ttattcatgt ttgatcttaa gacgattctc gaccatccta atatcccgtg gaaattaatc 642061 atttctgggt tctcgattgc ccaattttct ttcgaatctt acttgacgta cagacagtac 642121 cagaagctat ctgaaacaaa gttgccacct gtgctggaag acgaaattga tgatgaaact 642181 tttcataaat caaggaacta ctcccgggcc aaggccaagt tctccatttt cggtgacgtc 642241 tataacctag cccaaaagct agttttcatc aaatacgacc tcttccctaa aatctggcac 642301 atggccgttt ctttattgaa tgcagtcctg ccagtcagat ttcatatggt ctccactgtc 642361 gcacagagtt tatgcttctt gggtctctta tccagtttgt ctaccttggt tgatttgcca 642421 ctctcttact atagccattt tgtcctggaa gaaaaatttg gtttcaataa attgaccgtc 642481 caactatgga tcaccgatat gatcaagagt ctgactttgg cgtatgctat tggtggccca 642541 atcctttacc tgttccttaa gatctttgat aaattcccta ctgatttcct ttggtacatt 642601 atggtcttct tgttcgttgt ccaaatctta gccatgacaa tcattccagt cttcatcatg 642661 cccatgttta ataagttcac tccattggag gacggtgaac tgaaaaaatc tattgaaagt 642721 ttggccgata gagttgggtt ccctctagat aagatttttg tcattgacgg ctcaaaaaga 642781 tcttctcatt caaacgcata tttcacaggt ttgccattca cctccaagag aattgttttg 642841 ttcgacactt tagtgaacag taattctact gatgaaatta cggctgtttt ggcccatgaa 642901 atcggtcact ggcaaaaaaa ccacatcgtt aatatggtca tctttagtca attgcacacc 642961 ttcctcattt tctccctttt caccagcatc tacagaaata catcatttta caacaccttc 643021 ggctttttct tagagaagtc cactggcagt tttgttgatc ccgttatcac taaggaattc 643081 cccattatca ttggatttat gttatttaac gacttattaa ctccactcga atgtgccatg 643141 caattcgtga tgagtttaat ttccagaact catgaatatc aagctgatgc ttatgctaaa 643201 aaattgggct acaagcaaaa tctatgtagg gctctaattg atctacaaat caaaaacctt 643261 tccaccatga atgtagatcc tctgtattct agctatcatt attcccatcc aactctagct 643321 gaaagattga ccgctctaga ctatgttagt gaaaagaaga aaaactaatc tatagagtac 643381 acatattagc atgtaccgtt aaattcagct tcgttatgtc tatatctaca tacatacaca 643441 ggtatctact ataagaataa aggaaagaaa aaataaacga ttaaacattt tatttttttg 643501 catcgctatc atcattacct ttctcattgt tatcatcatt atctttccca tcttcatcgt 643561 cattttcttc atcattgatt atttcaatga tttctgtggt ttcagtcttc acggtaaatg 643621 gttggggttc ttcaatatcc tcatcattaa ccatgaattg gttcaatctt ttgaactctt 643681 catttttctc ctccctaatg gcattataca aaagaaaatt tatccaaact tctgcaaaac 643741 agtaaataaa aacagagtta ttgtgaacgt aaaagtttga ctcccaaagg tacgagatac 643801 ttgtcaaaat aaaaaaaatt agtaatctaa ctggcacaac agattggaag tatttaacat 643861 tgttttctaa caggggaatt agatcatgaa caccgttaag agtaaacaga agagcgaaaa 643921 gacccaattg accactataa cgtgacagtg ttaactgcgg taaattcatc gcttgcgtta 643981 agactatgaa atatgtattt tgcaaaatag aattaacgtt ctttaaacaa aagaaggcga 644041 tcgtgaataa aaatgctact ctgaaaaaag caatattggt ggagttcaag gcttgagcca 644101 ttttcttaga atttattctt tacttttgct gaatgcgata ctctattatg ttgtaaattg 644161 ttacactacc attcaattgt ctctctttaa agattgatcg acattatttt ctttactttt 644221 ttggtgtttt cgcgctaaaa gtggcgtgct aaatgccaag tattattcta aaaaatcatt 644281 acgccataca caaatattga agactatcta tctaacttaa caccaacttg ctttattaaa 644341 gagtcaatat ccttcaaaga cttagtgaaa tacaattcat cgtcaatata aggttcttca 644401 ccgtcgctat tgttcaagtt ttgtattgat tttaagtaat cctgcgtaca caggatactc 644461 actttactgt ccgtcgtgga tagttcattc cactgcctaa tacttaaatg gtttttcttg 644521 tgtcttttat acgttctaat tgaatcatag ttattctttc gcaatacaaa ggctattgaa 644581 catatagtct tacattggga acaaaatata tcgtattcct catcttcatc gtttggatca 644641 gtatgcacct ccaaaagagt tgtccgtggt acaatggcct gaattttccg tatgcgtttt 644701 aattcagtat tataaaagac gatcaatgaa gagtaacatt gcctaacaaa agcatcattg 644761 aacaatagag tatctttatt gtacttgtcc aaaacattga tcattaaatc aaacatatca 644821 aaaacacatg ctttctgagt taatttataa tccgtaatcg caccaaatcc atatggtagc 644881 cagaaatcta tagtaaaatt gacagcttca ttaaaattat aacctgtatt aaaaccagca 644941 tggtaacatt taggaaacgt gataatatat tcgttgggct tttgcacagc tttgtacaca 645001 ggaatacctg atttcttgaa atttggatcg tacggagata ttaaagtcac tagctgatgc 645061 agtaggtctg gttgtttgat aaataagtct ggtgacatat catttaatag atcgttgaat 645121 ttcgtacatc ccgattcggg aatgctgtac cagaccttag ggtcaccttc atgttgatag 645181 ttagcactta gggtatactg atcttccata tgccaacaaa atgtggaaaa taaggagcct 645241 atgtaaatcc aaggaatagt catgccagaa atatttcttt taaataacgg taatagcgaa 645301 ttatgagcca taggcaagtt agttaaattc ataggatgat cgcaatattt gaggtagtct 645361 atcaattcgt ccccatttat atttttgggt ataaattctc tcgtcggaaa gccggtaatt 645421 tgacctggca attcgttatg tatgtcagca ccgtatttaa ctgtcgttaa tgaactgcga 645481 cgattcttgg tcactaagct ccaaaacatc tcttccaact catctataga cagttttcgt 645541 gctggtaata accttgaatt ttgacgttta caatattctt gaaactctgg tagagaatag 645601 tcatgcgtgt cctgagtgaa tccgtaatat ccgtttccga cgatacaagt gttacaaatc 645661 caatcgccag agggaacacg ttccaaaggt ggtgataaac aatatatatg gaatggtttg 645721 tcacatgaat cacataaaat tgttcttttt ggatcatttg tcttgcgaca aacaatacaa 645781 gcatcatcat cgtcctcctc aaaatccgac ccagaattcg aatctggccc aagatcgaaa 645841 tcgtcctcgt catcacttaa taaggatttt ggatactggt cagcatgcag cgccgtgtgc 645901 acgttctcgt tcagtgaatg aagaaatatg tagtatgagg caatatattt ctcaaaaatt 645961 tcctttaaca agccgattgg tacgttgaat tttttagaaa tggtcctcca tagactgatg 646021 tcgcctctta attgggaaat atctctaaat ttcaattttc gcctgaatga ctgtgtagtg 646081 tcagtaagtg tccgattgtc ttttattagt tcagagaaaa cgtcataaaa gtacactttt 646141 ttttttagta tttccgatgc atgagtagaa tctgaatatt ctacaatcgt ataaggttcc 646201 ctaagtataa gtttcgatgg atccttaacg gatcttttaa aattatttaa ctgtttcata 646261 aaaaatagcc tacacctatt tttcaggtct aggttctcca gattttgaat tcttggttga 646321 aaagtaaaat tttccatatc aatagaaagt ggcgggcaga acccgtttgg tggtacgacc 646381 ttgaccatac catatcgtac accaagcctt ttaatgtggg ggttagagag ataatcgatc 646441 ggatttttga attcttgttc cgttggatac agggcaggaa tttcctccat gatagtgata 646501 cgttttttgt gcaagatgag attagttaat atgatctaga ggtaaaattg actaagtagt 646561 cagatcttat tctacattga gcctgcgttg tcaacatgca catctctgtc tcttgggatg 646621 ataatttttc aatgatgatt ccagggttac tttaacgtta cacaaaagaa attaattagt 646681 gcggctgttt ctgtgagcgg ggcagtaagt ccgaagccct tgatattagc ccatacccta 646741 cacattttac tcgtttgccc tacatcagat aaaatactgg ccctaagccc tcctaatctc 646801 ttctggttac acctagggta aaatatctgc ctttctttgc attcaatgcg ttacttctat 646861 atcacgagat gagcatacgg atcgtgtata atactaaaaa gaaagctcct gaaagagttg 646921 tgacaagcaa gactgtatac tactccttct acgaaagtta gttcgagttc ttgatggcac 646981 ttggctattc tatttcttga acctttgaga aagaacagaa gtaaaaggct gtgtattctg 647041 ctacatgaaa tacagtagta gtcacagtac aaaaatactc taaaccagta ataaagccac 647101 atatatatgt atttcctttc acgtgatgcg ctgggatgtt atcatcttat acgcaattag 647161 ccgcccatat gccacccggc gcaccgggtc gcacacacac ccccgtgatt cgcgatatat 647221 agcggccaat caacggcgac ctccaagcgc gtgccgggtg ggcccctcgc cggccaagca 647281 gcgcaaggat attcccatct tcgagctctt agatacaacg cttataaaga acgcactttt 647341 tgcattaacc tcttttttgt attacagaac aaacatttta acttgccctt ttttaaactt 647401 tctttatctc tccaggacag gccaattgga taaattttgc aaagatcaaa cagtaacaca 647461 aattttagca acctaaaccc ccctcataaa cgaagacaaa agtgctcctc ctcaagtcaa 647521 atttgtcttt cttttctttc attttttagt ctgttgttat ccaatttata ctgaatcttt 647581 gagagaaaac aaaaataaaa aaaagaatgg ttttgccaag actatatact gctacatccc 647641 gtgctgcttt taaagcagcc aaacaatccg ctccgcttct atccacttcg tggaaaagat 647701 gtatggcctc agctgctcaa tctactccaa tcaccggtaa agttaccgct gtcattggtg 647761 ccattgttga cgttcatttt gaacaatcag agttgcccgc tattttgaac gctttagaaa 647821 ttaaaacacc tcaaggtaag ttggttttgg aagttgctca acatttgggt gaaaacactg 647881 tcagaaccat tgctatggat ggtaccgaag gtttggtccg tggtgaaaag gttcttgaca 647941 ctggtggccc tatctccgtc ccagttggga gagaaacttt agggagaatc atcaacgtta 648001 tcggtgaacc tattgatgaa agaggtccaa ttaagtccaa actaagaaag ccaattcacg 648061 cagaccctcc tagttttgca gaacaatcta cttcggctga aattttggaa acaggtatca 648121 aagtcgtcga tctattagct ccttatgcca gaggtggtaa gattggtctt ttcggtggtg 648181 caggtgtcgg taagactgtg ttcattcaag aattgattaa caatatcgcc aaggcccatg 648241 gtggtttttc cgttttcacc ggtgttggtg aaagaacaag agaaggtaat gacttgtacc 648301 gtgaaatgaa ggaaactggt gtcattaact tggaaggtga atccaaggtc gccttagtgt 648361 tcggtcaaat gaacgaacct ccaggagcca gagccagagt cgctttaact ggtttgacga 648421 tcgctgaata tttcagagat gaagaaggtc aagatgtctt gttgtttatc gacaatatct 648481 ttagatttac tcaagctggt tcagaagtct ctgccctttt gggtcgtatt ccatctgccg 648541 tcggttatca accaactttg gccactgata tgggtctctt acaagaaaga attaccacca 648601 caaagaaggg ttctgtcact tctgtgcaag ccgtttatgt tccagccgat gatttaacag 648661 atcctgctcc tgccactact tttgcccatt tggacgctac taccgtcttg tcaagaggta 648721 tttcagaatt aggtatttac cctgcagtgg atccattgga ttctaaatca aggttattgg 648781 atgccgccgt tgtcggtcaa gaacattatg acgtcgcctc caaggttcaa gaaactttac 648841 agacctataa atctttacaa gatatcattg ctattttggg tatggatgaa ttgtccgaac 648901 aagataaact aactgtcgaa agggcaagaa agattcaaag attcttatct caaccatttg 648961 ctgtcgccga agtctttact ggtatcccag gtaaattagt gagattaaag gacaccgttg 649021 cctcgttcaa agccgttttg gaaggtaaat acgataatat accagaacat gctttctata 649081 tggttggtgg tattgaagat gttgttgcta aagctgaaaa gttagccgct gaagccaact 649141 agaagaaata aagcttaaac caagggaagc aaaatttgaa ataccgaagg tagaacaata 649201 aggatgatgg gaaaaaaaag ataatttttt ttttttgttt ttccctgctt ccttcttgtt 649261 tattggtatt attatgttac gatattcatt cattatccta ttgatatttt ctttatattc 649321 actaaaaaaa aatttattct ataagactga ctataatttt ttttactccc aactgtaagt 649381 aaataaagac tcacctacgc atacattttt tatatatact ataagatgta ggatcttaaa 649441 gaaaaataaa gagaaaaaga gaagcacaca acctgcgata agttgtaagt ttgcctcaac 649501 agctattcta ctcacttttt gtatcttcgg ttagtattat tgggaagtca tgttcatcgt 649561 actcactttc gcacatgcga ttacgtgtat taccctgatt ttctttctgt attagcgtat 649621 ggctgactaa tattcacttg gggtcaacat aacttacttt cacatatcat ggtagctgtt 649681 ttaattacca ttctattaga tgcgctgtat tccaaattac cgttctctca ttgagcttct 649741 tccttaaagg ttcttgcctc gctttcccac tggacatgtt catcagtaga agatgcagaa 649801 ttaaaggctt tacccttaag aatttgctgt ggttcaggtc atcatcaact cgatttgttt 649861 caactgaatc accagatgcg agcgcaatta cgaaaccaga tggtattttc aattattctc 649921 tgttggaaaa cagaacatac atcaggatac gaggacccga cacagtgaaa tttctaaacg 649981 gattagttac ctcgaaacta ttacctcatt ttattaagaa aaatctaacc actgtagaag 650041 agaatgaagt gcctactgaa gaaggaacga cgaaggttga tccaattatt cctgtgccag 650101 aatttgatgc acgactggga aattggggac tgtataacga aaaaggtatt caagggccat 650161 atatttcaag gtttggtttg tactctgcat ttttaaacgg taaggggaag ttaataacag 650221 atacaattat ttaccccact cctgtgaccg taagcgaaca aatttcaaat tatcctgagt 650281 atctgttaga gcttcacggg aatgtagtgg acaaaatttt gcacgtttta caaactcaca 650341 agttggccaa taagattaaa ttcgaaaaaa ttgatcattc ctccttgaaa acctgggatg 650401 ttgaggttca attccctaat ttgcccaaag atattgaaaa cccgtggttt gataatctac 650461 tggatcctat ggctctacca aaaaattcca tagatgctaa taattttgct gttaatgttt 650521 taaattcttt gtttaactca gatcctagaa tattgggtat ttacgtagaa agaagaactg 650581 agtcaatgtc aaggcattac tccacatttc cacaatcctt cagagttgtc acttccgagc 650641 aagtggatga tctctctaag ctatttaact ttaacgtttt cgacttccct tttcaagtaa 650701 ataaaaaagc ttccgttcaa gttagagaaa tcagatttca aaaaggtctt atagatagca 650761 ctgaggatta catatctgag actttgctac ctttggaact aaactttgat ttttttccaa 650821 acactataag cacaaacaaa ggatgttatg taggacaaga gctgacagcc aggacatatg 650881 ctacaggcat tctacggaaa cgtttggtcc cagttaagct ggataattat caacttttag 650941 atacagaccc agaaagaaag tacgcagaat tccatatcga caacgttgta gaaaagagcc 651001 ttgcagagaa cgagccaacc ctcaatccat ttaccaataa accgcccgaa cgaaccaaga 651061 gaaagcaaag gccggcaggc ttattgattt ctaatgaagg gctgtatggc gtagctttac 651121 ttagaacaga gcatttctct gctgccttct catctgatga gccagtcgaa ttttacatta 651181 ctacaacgaa gggtgaaaat attaaaataa cacctcaaaa accattctgg tttagcgact 651241 ggaaaaacaa taacgggcct cataaataga tttcacgaaa acaccttgta aatactactt 651301 gtgaatatgc aaataggaaa tagatatatg catacaaata agaaacaatg aacagccttg 651361 agttctcaaa tttgcatatc atttgttacg taattcctta tcaagacctt ttatacaaca 651421 acacccatat acccataatt attcttaacc catacatatt tgtctcaagt ttatttttca 651481 gatgagaatg gccctgcatc agtttttttc cagaaactaa ttcatggtaa caaacatttc 651541 gcgccctgct acggggaagg agaattcttt ttctcccgcc cagaacgtaa agccttgttt 651601 ctttctaccg tactgggccc gtctaattct gcccctttgc tgggaaatct cctttgcaag 651661 ctcccctacc ttcgccgcag gcttagtgga ggtctcactg aacccttcca ccttgggcca 651721 acttctacgc tcacgttagt aggtaatgga ttatccacaa tgtgcccatt agttctaaaa 651781 tattttgtac tttttatcaa tacttaaaat ttcattttga attaaaatta ctttttattt 651841 taattacact cctttcataa taccaagaaa agagactaga aataaccgac cattccaaag 651901 atgtctgaca ccgaagctcc agttgaagtt caagaagatt tcgaagttgt tgaagaattc 651961 accccagtcg tcttggctac tccaattcca gaagaagtcc aacaagctca aaccgagatt 652021 aagttgttca acaaatggtc ttttgaagaa gttgaagtta aggatgcttc tttggttgac 652081 tacgttcaag ttagacaacc aatctttgtt gctcacaccg ctggtcgtta cgccaacaag 652141 agattcagaa aggctcaatg tccaatcatt gaaagattga ccaactcctt gatgatgaac 652201 ggtagaaaca acggtaagaa attaaaggct gttagaatca tcaagcacac tttggacatc 652261 atcaatgtct tgactgacca aaacccaatc caagttgttg ttgacgctat caccaacact 652321 ggtccaagag aagacaccac cagagtcggt ggtggtggtg ctgctagacg tcaagctgtc 652381 gatgtttctc cattgagaag agttaaccaa gctattgctt tgttgaccat tggtgccaga 652441 gaagctgctt tcagaaacat caagaccatt gctgaaactt tggccgaaga attgatcaat 652501 gctgctaagg gttcctctac ttcttacgct atcaagaaga aggatgaatt ggaacgtgtt 652561 gccaagtcta accgttaaga agctaaaaaa agtgaaagat tttcaatatt acatatgttt 652621 ttcttattat tacttttatc ttctttgtac actctattgt ttaaatttat aacataatac 652681 aatcttatct tttgatgtaa aaaaaaatag gactatcaat ttttaaataa tatatcttac 652741 gcaaatctat caagtaaata taaatgctat tggttgtact tcctcgtgtg tcagatactt 652801 taactgggta ctatttacat tgtctctaaa cgtaacgttt ccttgaaatg atctacacat 652861 gtttctaagt cactctacat ttgctgctgc attaatggcg gttcatttgc tttttaattt 652921 tagcgtccac tcctaaaaac atgcatgcca gtattagatc cgccgttatc accaaggacc 652981 cactaatgat gtaacatagc cataaataat tattgttagc aagtataccc gtgaatattg 653041 gaccaacaca ccgagcaaat gtctttccaa tgttgaccac ccccataact ttggttaaat 653101 ctcttggttt gatgatattt gttaatagaa tttgccttgg tgtaacgtcc atggcagttg 653161 ttgcaaaatg cagattcaaa aacaaaatag ataagggcaa gtaattcttg gccataggga 653221 tgagaataga aaatatccct gatggaattt ggaccaatag tgtggctctt actgggccaa 653281 aacatctggc aattattgat gatgggatgg tggaagatgc cataaccagt tgcgtgatga 653341 aaaataaagt acccaacgcc agagatccca tcaaaaattg cttactatag tagtaaacca 653401 tccagccact tgtcataaac ccggacccga gagagtcgac catgaagatt actaacaatt 653461 tcatcaaaac cgaaacggtc tccttagata gtttgttgga tctttcttct gggtgagttg 653521 cttgtctcat taatggtgca gtttcatcgt taacgtccaa tggttcagct gtttcttcat 653581 tgcaatctgt atgttcataa tgcccgtcca attctgtagc atctgataat aagagcatga 653641 tgaccatttt gcaaaaggcg aagaaggcat acagtaagaa aactaattta taacattgca 653701 aatcagtagc agctaaacca gttcttttca aaagatctac aaatatacca caaattattg 653761 cacctagagc gcttccaatt gttccaacca aggcgtgaat agcataaatc tctggtcttg 653821 cattatgagg actcagatgt gcaatcatgg cctcttctat agatttgaaa ggcccgactt 653881 catcacttga aggcgatata acaccgaaga tagcaaatac tagcaagagg gtgaaatttt 653941 cgctaaaact gaaaaccaac ccacttaaca acatcattgc acaaccataa actaggactc 654001 ttcttcggcc ccaggaatcc gcataccaag taagaatgta agagcaaatt acatcccctg 654061 ccagtgttaa tgacataaac agcccaattt tatcctctgt catattgatg gcatttaaaa 654121 aaagcgtcaa aacttgattt gttaaaccat atgatagaag tctaagaaag acggacgccc 654181 atagtagctt tatgtctcta cttgcacact tgaatttaac aaaaatttcc ggtgccatgg 654241 ttacgttaac tttagaaata ttggtaaatc cttctgcaat gagctttttc gagatgtgaa 654301 aaattagtag agttttcttt cgtgcctttt ttttcggtgc gtcaacttta atatatagtt 654361 ataattgctc tataatgcta ggcaaaaata aacgagaagg aaggtgagtt ttagttcatt 654421 gactaaaaat gagcaaaaaa agtcaggagt ttttgttttg aagggcactt caactctcga 654481 actatggatt tacagtttct tcctcgtctt tttaagtaaa gtattttcaa atgaccaaaa 654541 tgtaaataaa tttgaaaagg gcccttcttt acgaaaaaaa gatcaaaaaa atgttcacaa 654601 actatttcac gaaatcaaga caaacatata aaggagaaat acagtggaga ttagatagta 654661 atgttcgtaa tacctgttac aaagtacttt ctattgttat aaaacattta catattgtgt 654721 aaaccaataa tatcactcaa aaggaaagta aatcgatttc tttggatgat gtatggttat 654781 tattggtatt ctgttcttgt tgaacagctc caccatgcat ttcaccaaat tcgtcatcat 654841 catcttgatc tgtacttagt gcagttgtgc tattagatac aggattagag gcagcggctt 654901 tcgcttggga tgctttagga gcactaggtg cttctgcaga tgcctttgca gttgaaaaga 654961 gagagctaaa aggatctact tttttaggtt ccgcaatagc tggggtaatc ttgccttggt 655021 cggtagtgga gctgttataa aaaggcattg aactcgtggt ggcgggcata ccctcaattg 655081 ggctcgtgtt tagcaagtta aacgaattag cagggttggt aacagggacg gcgctttgaa 655141 attctgaaaa ctcgtcatca tcgtcctctt cttcgtccgc cttcttttca tcttcttgta 655201 tgagttcttt agatggtttt gaagactcac tagaaaaaaa gtcaacaaag tcctctggtt 655261 cttgttttcc ttgcccagga gtagatgtgg ctctcgaggc attatcgtta tatccatttt 655321 gactaaaaga accatcttcg ttatcttcat tgtcactatc gaaatcagca ctcacgctaa 655381 tgccgtgcac tttcgttgac gtgaaacctg ccttcgaatt caaactgcca tcagcagagg 655441 cagatcctcc agcaacgccc ttgtacttct ttgccgtttc tcttgccttt tttctttctg 655501 cgcgtatctt attatcgtcg ctcaataatt caatcaaagc tttgacccta gttctgacat 655561 taattccttg atctcttccc tgggaatcaa tatagtgaaa agtttctaaa atcctaatta 655621 agttaatgct attccttgta tcatcgataa acctttcaga accgtgtttg ataaggtaat 655681 cgagcaattg caaggcttta taaatttgcc tccactcact acctgccttt tcagtgaacc 655741 ttctgaatat catggacaaa atttcttctc tttccctgaa attgtaagtt ccttgagaaa 655801 tctggtccat taaagtggat gaggcacccc aaggctcgtt gtttgtcgct tcacgaactt 655861 tcccctccat ctcagtataa ttgaaaacaa cattttgagc tttacgaaaa tatttcttgg 655921 cgtcatataa tgacatgttg gctaatgtat cctctaaact cattcttcct aacactaatt 655981 aacgatgtga tctcctatcg acgtccctac accttcctga attggtaatt tttgctttcc 656041 tcaaataact gtatctacaa atcatttcat gattcttcta gtcccctttt acttttccta 656101 atcacctcgc acaacgtacg gtgtgacatg tataagaaat tgaagccatg tttatagagt 656161 atatacaaaa aagcctctca tggttattat tcaaagtcac tctacgtatg caaataaaat 656221 aaatgtatat actgaggtga ggtacttaaa tgcttattga agtaaatagc gaacgttgct 656281 gaattggctt agcaaaatgg ttaaccactg aatgacctcg tttctatcaa tatcagccaa 656341 tccttcgtga aggccgggca aaacttcccc gacagatccc tcaaacttac taggtgctaa 656401 aagagagtac ttcatccatt ccctgtcttt cagtcctctg tgtgtaataa ataattgatc 656461 aatttgcttt gatttgctat tggatcgttg cagtttaata tagctcttga tttttttgta 656521 aaaagcccaa acaggtaaag cttccctaca ctctttatag agaataccat tttgttggtc 656581 aaattggatg ctatcttcct gtgtggcaac ttttaataag tccagaaccc tttttgctaa 656641 gctgttcact tcatcgtcct ggggaaatgc tgaagataga ttagagtgcc atgcgatata 656701 ccagttatat attttcttca ggtaaacatg tgtattgaat cttgccagtt cgttttcact 656761 cagcatcagc gttgtcaaac ctacaaacat ggccatggtg ttgtgtaact tgtagtcaga 656821 attggtaaat ttttccaacc aagttgggct atcgaatacg gagttactat gatagactgc 656881 gcctgaagta tcattggcat taaactgaaa atgtgcagcg ggcactccaa gatggtactg 656941 aaatgaagtg taactagaca acccatcaag tagagaaata gtggcattag aagtgtattt 657001 ccaatggtcg aacaatgacc agtcttcgtg cccattaaat tccgtgagct tagcagcttc 657061 gtatatcacg tcttgtaaaa gtgggttggc tttacagtga aaatttgtcc cagagattgc 657121 attatctaga tttaggtata ccaaggccct tctcctgaga atcgcagcat gagcttctgc 657181 ataatctgta gatcccagaa ggccggatcg ttcaccatcc caacttatta gtttgatagg 657241 acgcagtggc ttccaaccat gcttaagtaa tttactcatt cctcgtgcaa tttctaaaag 657301 aatagcgctg ccactatttg catcaccggc gctactcgag gcgagcgaat ccctatgagc 657361 tccgataata atctccccct cagtgaatat accagggata ctaacctcta cactactcat 657421 ttccttgatg ttgtaagtta gctcattatg caaatggact ttatcgatag agcttgaagg 657481 tccagtgaat gatccaaaat cttttatatt actaccgggc ccaatttgaa aacccctgcc 657541 attcaatctt tctaaaattg gttggacatc tctagcactc atcggcaccg atggtatcct 657601 cggcactctc cctaccggtg acatatgttc agtgtcggaa tccttggagg gataccctgg 657661 agttgtcgga tctcctggag tgtcactgaa atagtttaca gaatctctcc taatataact 657721 tgggtttctt gctggtccat aaggatagtg taaaaaccca ttttcctcag taactttacc 657781 atcgtcaaat gggtctgtat atataatgac actggaagcg ccataaagtt ctgcattctt 657841 tacctttaat ccaggtaata ttttacccga tcgtacgatg tggattttat cttcaatatc 657901 aatgtttttc ttcaaaagta gcttgtaatc actgatgcta ccataattgc aaaacacgta 657961 tcgagcagtt acacttccat tttttgaata ttgatggaaa cccttttgcc ttttcctagc 658021 gtgagaagca ggatcacctt taactctatc ctcgatcatg cttgcttcgt agaccacttt 658081 accattttct aaaggagcta cgttagtgtc tactggttca cctatccatg ggtaatattt 658141 ttcaactttg ggtttgtacc ccatatctag aaactcgtcc aaggtatatt taaacgttga 658201 cgaatcactt gctccgttgc tcatgtaccc agcatacttg tatacatgtt ctttcgctct 658261 attttcctgt tgcaaggagt tcaagtatat cctataaacc tctgcattcg tcaatctgga 658321 agagtgaaac cgccgaaagt ctcttgataa agacgtcctg ggagcaaatg cggcaacaaa 658381 tcccatgtac aaaaggagac tcgctagaat caagtacata aacttttcct tgtccatatg 658441 ttctttcatt atttcataac cactaacaat actagatatt gtattacttc tgcctctatt 658501 cctggatgtt aaagtgaaag aatcattcat gctttcttca ttgtcatcgc gagtggtctc 658561 gccactatat tgttgtaatc cagtggcttc ggcctcattg tcatcagggt ctgccatatt 658621 aacaacagtt ctctccttta attgaccttc ctctttctct ctctttctct ctctctgtat 658681 cattctcata tatctcttac attcttaatt gtgcatgttg aaattgtttt aataagtacg 658741 gccccttgcc ttgtcaaacc tttttacccg ggccatcaaa ctcaagcaaa ctccgaatgg 658801 aacaatgcct ttttgaagcc tggtggtata ttatgaaagt tatgatagtt ctaagcttta 658861 attctgtaaa tactatagta tagagacggc cgccattata tatttgtaaa tcggacttat 658921 attctagtgt ttcttttttt cgtaacacta tagatagctc ttgattgcaa accatgagcg 658981 aacgataata ttataggcca aattggcgca tcacccaata tttgaacacc caaatataaa 659041 catttggagg atagacttgc cgctacaatt agttgaattg tctcatttat atcggtattc 659101 gggtccatgg ccctttgtgc ttgttcttca tttagtgctg acaaatctag ggcatccttg 659161 tcctgccatc ttaagaaatc agtgtacgat ttcaacacat cacactcctt cggtatcaag 659221 ttcatttgta atcttctcaa aatcctttct gcttttagcc ataagacacg gtccgaaaaa 659281 tccaataatg ctgagttagg gttgttggca ttgtacccgc gtgcccaatc ctctacacat 659341 ttcatgtatt ccgaaatcac taatactgca gtgaacatac atgtggtcgc aaatacagga 659401 gtattgaaaa ttctgcgctt gccctgttta atgtacgtaa aaaatgaagt ccacgcatcc 659461 accatattca gtgcatactc ggtagcttcc ctcaatgaac ccatgtcata gcaaacttcc 659521 tccaaagctt tattcatatt ggaccaatct ttcaaccaga ttttctcaat aacatgtgcc 659581 aggtccaaac accgtctcat tttggcaaac aaatataccg gaattattaa cctcattgct 659641 ggattggcgt ttattgttga catgctattc tcggtaggtg tcaagatgcc accatttttc 659701 aaataaaggt tttcccagta ttttaacatt gtatcgatcc gttgtctgga agtcatcttc 659761 cactcaatat cgtccaactc aatgttattg ctattggtgt tgttattact gatccttgcg 659821 ttatttcttt caataagtat tttctcatgg atagatatca acaatgatag acatgtactt 659881 aacgaaaccc tagcatttcc gtaaaaaaaa ctatcgcctg tagaaagaaa cctcaaacaa 659941 ttttcatatg cctcgttacc attagacaat tcaatcaacg aaaatttcga atctaacgtt 660001 attttgtatt gacataatag gtccgaccat tcatcggaat ttcggcactg atataattct 660061 tctttatagc atggaacacc acattttaaa tcgactgaat gaaaacagca atcagcacct 660121 accagtgaag aaaataagtt agatataagt aataccgcat ggcaagtcct gatacgtgac 660181 tgcgccaata caaaatattg gtagtttttg ttcatttgat tcggcgcgtt gtattgctct 660241 cttatttttg aaaacatatg aggactgttt tcatattcca taatatgatc actctcaata 660301 ggcggctggc atagggactc taggggcaaa tttaaacgag aggccttcaa gagacgaata 660361 atagtcgtca actgaccatg catccccttg atcacggctg tatttttatt gaaaatacag 660421 tagaacgtta gcaatactaa tgtctgtata acccataact ctgtcgtctc cgggtttttc 660481 tcactaactt tcaagctttt cctaatttgg gtgctagctg cattagctaa cacttttgca 660541 tgcgtcgaat gaaacccata caatgctccg accatggaga tagataataa caagggataa 660601 ctgtccatat taggtatgat agaaggaaga tgaataaatg aaaaaaatgg atggaattct 660661 tccttatagt aagtcacata atcgttcaat tgactagttg tggggaaggc tcctgaatcg 660721 atattattgt cggctagcat catactcctt agctcattgg taaaaagcac ttgagatact 660781 gaagggacag aaaacggaga taacaaatcc gaaggagtaa gaacaggcag ctgtttctgt 660841 gttgcattag aatcagtttc gccggggaaa gacaaagtga gaacatcgtc gttcacatga 660901 gaattatttt gctctgtccc gtttaatacc ttggaaatat ccaattgcct tgagctgaaa 660961 aaattggata gatcgtagtc catcatgacg ctatcacgac gcctcttatg agaactatgg 661021 gaaatagggt cagaatagga aggctccttt agttggtttt gtggtgtact tggtaaatct 661081 gtgcttccat tcaaactcaa gtttaagcga ggtgataaag aagctttttc atgatttaat 661141 gaggtagcag aatggtttgg aggtgacttg tttggtatag atgaccttga tgaaggtgga 661201 gaataaataa acccaatgtc attgaaatga ttgaagttga tcttgaaggt agattttgga 661261 tcagagttgt taataaactc tgataaccac ttgtcatcta tggcagcagg atcgatatta 661321 ctatccttat cattgggctc cattgatggt tccagtaaat tatttgtgcc tggattgaaa 661381 ttgatcgtgg aagaggaatc tgaaacagtt gttggtgggt ttttaggaga tagtgacata 661441 agcggctgct cattgctcat ttgcctataa gtttgatttg ccaaattact gtaactatta 661501 gaagccgtag tagaattaga cggtatagta ttcgggaagc ttgacggaag gttaaattca 661561 gaaactgtcg gtttatcatg actgaagcag cccaaatcaa atggcgaatg gtggctagac 661621 atgtatcctc ccgcacctgc atgtgcagag ttcattgtca aaagatcggt taaagatgga 661681 ccgctactta agagatacac tccaggtgta gcaactgtac ttccattgtt gctgttcact 661741 atggtactag aggtggaatt ttgctgttgt tgttgttgtt gttgttgctg tccggagggg 661801 tcattgttaa atagatttaa gttaaacttg atagcttgcg gtggttcgtc cagggttaac 661861 ggaggtaaat ccaattctga cacgctttcc atgagctgct tcgcggtcat ttgtggagta 661921 gaaaagccga cttgatgcgg agcgtcttca acgagctcga aattggtaat tgaatggtgg 661981 gggctattgc tactagacat gtaagtcatt gcactggatg cagagaaaga cgcatgtctt 662041 ttcgtcttat gcatggaaga gggagtgttc gccctgtcga taacagcatc gcttgatgca 662101 gagtgaactg gcacgccttt cgtgctgaac ttgaactctc gaaatcctag ggagcctgcc 662161 ttactaggag gagttttctc tcgcttatcg ttcattactg gggccgagac gggaagttct 662221 acattatttg atttggccaa ggcaaccacg gcctctttca attcttcaga tgtcttacca 662281 gcaaggttct tcggggtggg tagaatagtc tctttatttc cggctatttt aatgatatga 662341 aggtcggttg gatcatccgc cgccacggaa tggcgccgct tggaggcaaa agaagaagtc 662401 gaatttggtg ctggcgtcat tcgccgtgga tcccccgtac ctacaagagc agcatgaagt 662461 ttttgctgat gcctgagcac taaatctcta cgagcaaaac acctaccgca aaagatacaa 662521 agatacggtt tctcacgggt atgcgaatgc tgatgtctct tcaaatgctc ctgcctgaca 662581 aaacccctag tgcatgtggg acacaagaac ggtcttggct tatcagtctt aataattcga 662641 gattttttag gaatgggcag aataccttga ccagcgggct tagcgaaatt agattgatta 662701 ccgttcacaa acatacttgg ctccggcact aataaaaaat ctttatctgc cctatctatt 662761 ctagtatcgc caatgtcttt tagcttcttc gccctaaagt ttctttttgg tgcaagagtc 662821 ttcgagaaaa acgtgtgttg agagaggcaa tgtttaacga agaaaaaaaa ctctatggaa 662881 atccaagaag tccttgtttc tttgttttcg tttctaatat atgcagggtc aagcgggaaa 662941 aagaaagaca gacggaaaag tgcccagcaa cacggaacaa aattgtccag atttattcga 663001 gcggccgcgg ttagtatgca taatgcaggc gcccctcgtc caaatgcgaa cggttccatc 663061 cgaaacaggc catttcccaa aaattatttc tcttaataga agttgctcgc gtagttacct 663121 attgtcgatg ccgcatacgc agttacctta tccgttgccc tacggagaat ttccgcgatg 663181 cagcaccgtg cggcgagatc acaattttcc ttgtacactc tactctgccc ctggagtggt 663241 tcacccccgt ctgtgcgtat tttcgtgtat gatgatataa ggtcgttact accgttgatt 663301 caaaaacagt tgcttcttcc atatattgta gcacgaacaa ctatggccgg ccgcaaattg 663361 cgacaattac acctaacgca gcattaaggt cgcaggaaat gttatctgcc gagctgttta 663421 tctctgtttt ccaagatttt ttcaaccagc ccatgagtct gctgttggcg gcaacccagt 663481 tacagataat ggtgcatgtg ataagcttcg taccactatt cgtagtttgt tacatcttgt 663541 aagccagtat atatatttgt tagattgtgc cctaacgttc cagtaattga agggtaaccg 663601 aggtttccgt ggaaaaaaac cgtgtataag caagaggttc cgagcgaaaa aaaaaagtat 663661 aaaagaaagc acaggcaatg agatttgttt ttcgcttttc cttcttattt gttaattcta 663721 tttttgaagt ttccttccga aaaaaagtaa ctttgtccta aagtactaat ccaccgcatt 663781 agacagtacg aagatcgagc tatttatttg aacactcggt cttattcgtg ataagcgtaa 663841 tgtggagaga tcaatttccg ggtcatttat aagaactcga gtggattgct agttgttttg 663901 attagctgaa tgagactcga gtgtcagaag atgactatat tttttttctt ttttttttta 663961 gttatgtttt atttttgaac ttgtacttgc acatgtatct tattgtttcg tgatcttgta 664021 gatccgtatg ggtgcaatca aaggtttgaa ttgcagggct ttcatcgcgc ggatctcgtt 664081 gtttgcgtcg tactctgtgc tggtgactat ggtacatttt agcccgagtt tattgcactc 664141 ttgagaaaac agttggacag tggattcgct tctaattgtc gcggatagga gacacagttt 664201 gcatcggtct aaagcaagac attcggccag acactcgcat agatcaggaa ggatagttgg 664261 gtcatacgta acatctgccc ccactactaa atctatatcc tcaggaactc tatcgctgcc 664321 ccaccataat ctttgcaact tgatgtctgg ttcgttctca cgcacttcat tgttcaattc 664381 aaaatttctt ttcagctgcg tctcaacgag attcgaatca ccatccgtga cgtacatctt 664441 atttacgaac tcgtgatact tttgtaaaat gacgagactc actatgcctg tgccagcgcc 664501 gacctcaaga acatttaatt ttttcttgcc atcgtcttgt ccttgtaccg gtgccaactc 664561 ttgtaagggc ttatgaataa ggaaatcacc catgtataag gcagcttccc atgtcctgaa 664621 acctgtagta ctggccgcac tgatcaaatt cggtgtttcc tcaattttga tctttacgtc 664681 ctcgtcaaac ctgtacctca cgacgtcttt catcatcggg tctggcttgc ctgtgcttaa 664741 tagttttatg tacttctcat agagataatc atatatctct atctcgtctt cgccatcgtt 664801 gacaattgtg aatgccttcg cgaaaatcca ttcgtggtct aagagcatct tgactatggt 664861 tttgcaataa tatgcattcg tcttttgcac aagttccatc tcacaaacaa atctcgatgc 664921 atgcaggaca tcgttagatt tgcttgtttc caactcttct agcaagtatt ttccagggca 664981 ccgctgatgt aatctatcgt agaatagatc ttcattcatg ttatctttga cgaggagggt 665041 caagttttac tagctcgatt tttctgcttt cttttccttt ttcatttact tatacattct 665101 tcatcatttt tgcgatgatg tactaactgc tagtatttat ttcgctgttt gtcgtgtccg 665161 gacaatcagc attaaaattt tctacagagt tttctaatac atataaacat tttggcttta 665221 ttcccctaaa gctttctcaa tggcacgctg aaaaacattg cataaaacgt cgctattttc 665281 caaaccgacg ctcactctta caagatttgt ttcgacacca tattgagcta cctcgtctaa 665341 ttcctggtag tgggcaataa tagcatatgg acacgccaaa gtgaaattcg taccgagaga 665401 aggtcctttg cacaattcca gattattgaa aaacttcttt gcctcttcaa tattgaaaaa 665461 agttagtgaa aataaacctc catacccacc atcttttgta gacataacgc tgtcataatt 665521 ccgcttggta tcctctgatg ttaaactggg gtaatatatt ttcttgaaca attttcccac 665581 ctgaggcaat aacacccttt ttaacaatat atcagtgttt gtattcacct tgattgtacg 665641 ttccacgaag tctctcgaat ttctttccag gcataacgca tcttcgcacc ataggcaatc 665701 ttcatatccg tcttcagtct tcataaattt tctagcaaac tcataaatct ttcctctagg 665761 atttagtact aaggatcctg caataacgtt cgagtcgccg ctgaagattt tcgttagcga 665821 actacaaaca atatcggcat acggtaatac atctatattg acaaagccac ccacagtttc 665881 atcgaccact atgtaaaatg aatacaagtc tgatagcctt ttcagttctt gtaaatctcc 665941 cattttcaac agtgggttcg atggagcttc tataaatacc gccagtattt gctcaccaga 666001 atgtaaaata tttttcagag cgttcattga cgttgaatct ccctgtccca agaaatgtgt 666061 gtgattgaac ttccgaagaa tgctcagagt atctgtatat gggaatccaa acatgacggt 666121 cttcttgaac ggaggtccat atccaatcaa cttatcttgt ctactagaag accttgataa 666181 gcgcttggca tcgaagttta aaagcagcct gtgggcagtg aaaatggacg ccattccact 666241 tggaaataag taaacatccg tattagggtt gacatgaaac ttcaagtcat cggtagctgt 666301 gttttcaaaa gtactgtttg agccactttc tcccatagaa gtaattgttt cggcaggtat 666361 gtccgaattc aactgatcat catccagagc ctctccactg ccaacattga atggaccgtt 666421 gctctcgtta tagtgttcaa aagagaatag gtccgataga ccttcagagt caattttttc 666481 aacaactttt gtggcaatcc tctttcgtat tagatatttg gctttatcag cagcaagaaa 666541 atttaaattt ctcccaaatc tcgtttctat atattcttcg ttcactctgt tttcatcttc 666601 ggtcataaat tttttaccgt tatccactgt ttccatcttc ttaagattat ccttgacttg 666661 taattcatgt aaaatatact ccgccattct gctagataca atctcaccag aatgttgcca 666721 atactgcttc atcacgggga atatttcctg gtctacaaac accaccgtga ttttacattc 666781 ccttctccag agcttttcct cttggttcat aggtttaggt gtacatagtt gtaagatgcg 666841 tactttggta gaaagacccg ttttcacttt gataaactct ctgcacctat tggcaacctt 666901 gtaagagggg aagcaaagac aagcttcatc ttccatggag tacttagcgg ataaaatttc 666961 acataatttc tttattgact tgtgtatgaa aaatcttgga tatccggtag taagcgagtt 667021 aattatactg ctttcaccct cttcatagcc tactgtagct tcccatgtgg gcaaacacac 667081 ggaaacagca tgttttgtgt tgggcggaat agattcacca atggttctag atatcatttt 667141 ttcttctgtt cctcttctct ctcttgttta tgtaggtccc gaatcggcac atgagcgtca 667201 ttctactatc gttatatata tgggtatata tatatatata tatccaaaat atatgactaa 667261 tttttagacc gagatattgt gaagtgcaga ggcgctatca tgatttttgt tttttacatc 667321 cacgcatgaa gataagtcat atttactagg tttgaagggt tttacctgaa caacactggc 667381 aatcattgaa gttaattgag ttcttaaacc gcaagatatt ttaatatgaa tactgctatt 667441 tttaaataag actgtagcaa aatgtggggt taaactttta caaattcact ttggttgtaa 667501 cgcattttct gtggaagagc aattatttgg aattttcagt ttcgccaaac gaaagaatga 667561 aagaaatgtg ctttgccaag aaacgaaaga cgacagaaaa aggtagtaaa agaggaaaag 667621 gttaaacatt gaaaaaggat tctatgaaga actctgtcgg tatttcaatt gcaaccattg 667681 ttgctatcat agcagctata tactatgtgc catggtacga acactttgag agaaagtcac 667741 cgggggccgg agaaatgaga gatcggattg aaagcatgtt cttggaatcg tggagagact 667801 attccaagca tggctgggga tacgatgtgt atggacctat tgagcacact tcccataata 667861 tgcctcgtgg caaccagccg ttaggctgga ttatcgtaga ttcagtggat accttgatgt 667921 taatgtataa ctcctccaca ctatacaaaa gtgagttcga ggcagaaatt cagagatcgg 667981 agcattggat aaacgatgtt ttggattttg atattgatgc cgaagtgaat gtttttgaaa 668041 ctactattag aatgctaggt ggtttattat ccgcatatca tctatctgat gttttagaag 668101 taggtaataa gactgtctac ttgaacaaag caatagattt gggggatagg cttgctttgg 668161 cgttcttatc cactcagacc ggaattccat actcaagtat aaaccttcat agtggccaag 668221 cggttaagaa ccatgcagat gggggggcat cttctaccgc agaattcact acgctacaaa 668281 tggaattcaa atatctggcg tatttgacag gaaatcgtac ttattgggag ctggtggagc 668341 gtgtttacga gccattatac aaaaataacg atcttctaaa tacctacgat ggattggttc 668401 caatttatac atttccagat actgggaagt ttggtgcttc gactatccgg ttcggatcaa 668461 gaggtgattc tttttatgag tatttactaa aacaatattt attgacgcac gaaacacttt 668521 attatgatct gtacagaaaa tccatggaag gtatgaaaaa gcatttatta gcacaatcca 668581 aaccctcttc tctgtggtac attggggaaa gagaacaagg tctacatgga caactttctc 668641 ctaagatgga ccacctcgtg tgctttatgg ggggattgtt agcatcaggc tctactgagg 668701 gcctttctat tcatgaagcc cgaagacgtc cgtttttctc tctttccctt gaaagaaaaa 668761 gtgactggga tttggctaaa gggataactg acacatgtta tcaaatgtac aagcagtctt 668821 cctcggggct tgcgcctgaa atcgttgtct tcaatgatgg aaacataaaa caggatggtt 668881 ggtggcggtc gtctgtgggt gatttttttg ttaaaccact cgataggcac aacctacaaa 668941 gaccagaaac ggtggaatcg attatgttca tgtatcattt atctcatgat cacaaatatc 669001 gtgaatgggg ggcggaaatc gcaactagct tctttgaaaa tacctgtgtt gattgtaatg 669061 acccaaaatt aaggcggttc accagtttaa gtgattgtat cacgttacct acaaagaaat 669121 ctaacaatat ggaaagtttc tggttggcag agactttaaa gtatttatat atattgtttt 669181 tagacgagtt tgatttgacc aaagttgttt tcaacacaga agctcatcct tttccagtat 669241 tagacgaaga aatattaaaa tcgcagtctc tgaccacagg ttggtcgttg taggttagtg 669301 tgctatatag tggccagatt cgccttttaa aattcactat gcggtgtgat gatgtgctat 669361 accatttttt ccatgtttag gaaaatgaaa aatttgcaat gcttacttca gcaaaaaagt 669421 atatttgaat caatattcat ttatatattt cagcataatc aatcattttt cgtctggata 669481 tttgacacaa ttttgatttt gacgaagaca ttttattctc gatggatatt acagaattgt 669541 tacagtgctt tgcctgtact ttggaccata acgctgccgt aagaactaat gcagaaacac 669601 atcttaaaaa tgcaagtaaa gtaccgggat tcttaggcgc atgcctggat atcattgctg 669661 ctgatgaagt accagaaaac atcaaattat cagcttcctt atatttcaag aataagatta 669721 catacggatg gtctgctggt gcaagacagg gttcaaatga attattagat tcacatgttg 669781 atccggatga aaaaccagta gtaaaagata tgttaattaa aacaatggtc agtgtgtcca 669841 agacctcccc gcgttgtatc agagtgctaa aatctgccct tactgtaatt atttcagaag 669901 attaccctag caaaaaatgg ggcaatttgt taccaaattc cttagaatta ctcgcaaatg 669961 aagacatcac agtaacatat gtcggacttc tgtgtcttgc tgagattttt aggacctata 670021 ggtggaagaa taatgatgaa agacaggact tagaagagtt gattttaaat tatttccctg 670081 ctttattaaa ctatggcgca aatgtccttt tccaagatgg taaatatatg aataacgagc 670141 aaattggcga attggtaaaa ttaatcatta aaatttataa gttcgtttca taccatgacc 670201 taccatttac attacaacgc tcagaatcgt ttaccccatg ggcatgtttt tttgtcagca 670261 tcattcagca gccattgcct caggaagttt tggctatatc agatattgag gtcagaagta 670321 aaaatccatg ggtcaaatgt aagaaatggg ctcttgcaaa cctttataga cttttccaga 670381 gatacgcatc aacgtcatta acaaggaagt ttcagtacga tgagtttaaa cagatgtact 670441 gtgaagagtt tttgactcag tttttgcaag tcgtcttcga tcaaatcgag aaatggggaa 670501 ctggacagtt gtggttaagt gacgaatgct tatactacat attgaacttt gttgagcagt 670561 gtgttgtgca gaaaacaact tggaaacttg ttgggcccca ctacaatgta atacttcaac 670621 atgtcatttt cccactacta aagcccactg cagagacttt ggaggccttt gacaatgacc 670681 ctcaagaata tatcaaccgg aatatggact tttgggatgt cggctattcc ccagatcttg 670741 ccgcactggc tttgctaacg acatgcgtga cgaaacgcgg taaaacgacc ttacaaccga 670801 ccttagaatt tatggtctca accttacaaa gtgccgttgg tgattacaac aatattatgt 670861 tggataatgc cttgcaaatt gagtcctgtt tgagaatatt ctccagcatt attgaccgtt 670921 tgataactaa agattctcca tttgccagtg agatggaaaa gtttatattg acatacgttt 670981 tacctttttt taagtctcag tatgggtttc tgcaaagtcg tgtttgcgat atttgttcga 671041 agttgggttc tatggatttc aaagacccgg taataacctc tactatctac gaaggtgtta 671101 tgaattgtct gaataactct tctaattctt tacctgtaga attgacagct gcattggcat 671161 tgcaaacttt tatcagtgat gaccagttta atatgaagtt atccgaacac gttgttccta 671221 ctatgcagaa attactaagt ttgtctaatg attttgaatc tgatgtcatt tcaggcgtta 671281 tgcaagattt tgtggagcag tttgctgagc aattacaacc ttttggtgtt gaattaatga 671341 acactttggt ccaacagttt ttgaaattag ctattgatct gcatgaaaca tccaatttgg 671401 atccagattc cttcacgaac gttgatagca tacccgatga atctgacaag caaatggcgg 671461 cgctaggtat tttgtcgact acgatatcta ttctgttgtc ttttgagaat tcacctgaaa 671521 ttttaaaaaa cttggaacag tcattttatc cagctgcaga gtttattttg aaaaacgaca 671581 tcgaagattt ctatcgcgaa tgttgcgaat ttgtagagaa ctctacattc ctactaagag 671641 atatcacacc catcagctgg aaaattttgg agctgattgg agaatgtaat agaaaaccag 671701 atagtatggt atcttattat ttaagtgatt tcatgctagc cttaaataat atcctcattt 671761 atggaaggaa cgaattaaag aagaacgagt tttacacaaa aatcatattc gaaatatatc 671821 aaaaggctgt tactgcagaa gataattcgt tagacgatct tagagtggtt tttgatttat 671881 cccaagagtt ggttcttgca ttagatgaca gtttacctca acaatacaga gagcgcctac 671941 tggcggatgt tgtcggctct attctaacgc aaaagaatga attgaaaact aatgttgtat 672001 ttagtgtgac tgcttttaat gtcgtaatct caaatatgat aacagagcct ttgatcacgc 672061 ttcagtacct gaaacagcaa ggttgtcttg aaatcttctt tcaaacgtgg attacagact 672121 atattccgaa ttataaaagg tgctatgata tcaaattatc agttcttgcg ttattaaaaa 672181 ttatactgaa gttagaaagc aacgattatt cagtgttgaa cttagaaaat ttggttccgc 672241 aattagggag tattgttacg cagttagctt cgaggctacc aacggcgtta aggcaattag 672301 ctaaccaacg caaggaattc tcatcatccg gttttgaaga ggatactaag tgggatgaaa 672361 attttcttga cgttggagac gatgatgaaa atgatgacga gggagacctt actgagaaat 672421 atctggaact gataaaaaat agagccgatt ccttggactt cgtagatggt tatgacgcaa 672481 aggaaacttt cgatgaccta gaagaggacc cattaacggg gtcgatcctg gacacagttg 672541 acgtatacaa ggttttcaag gagtccattg cgaacttaca acatgttgac agcaatagat 672601 atcagggaat cttgagacat ctgaccccgg ctgatcaaga actattcatg ggaattatga 672661 atgcctaatt gaattaaatg gcgattgtat attgaaacaa acactggatt acataattta 672721 gatagaagag agaggatatt atgctcaaag tttgttgcct ttgcctcggc cagttgactt 672781 tgatttgata tcaagatctt ttttttttat ctggagtcaa tgcgatgaac ctaaaaaaat 672841 cacaagcttt ttttatctct aagctgggga aagaatcgta gttaaatcgg aaagaaaaat 672901 atctgagttt tgtcagtctt tcttttgcat agcccatcct tgtactagat ttcataaaca 672961 ttgatcactt caaaatatac ttgtaccaag atggccgaaa atgagagaat gtacatctcc 673021 tataataata ttcacaagct ttgtcaggga gtggctaaac atatcttagc tagaaacgaa 673081 agacctgata ttattatcgc catcactggt ggtggtatga tccccgcaag aattattagg 673141 tcctttttga aaactaaagg acaaaagaat attccgattc aggccatcgg cctatctttg 673201 tatgaagatt tagggttgga taatagcgtc gaaactatcg gcaaagaggt catcagaaca 673261 caatggctgg acttcggtgc tttgaaccaa catttcgatt ccttaattgg taaaaaggtc 673321 ctaattgtgg atgaagttga cgatactaga actaccctcc actatgctgt ttctgagctg 673381 gaaaaagaga ttgctgaaca acaaaaggtt ttgaatagaa tgagtgagga aaccgttatt 673441 tctatctttg ttctacataa taaggacaaa ccaaagagag ctggactacc tgactccatg 673501 atgaattctg gacgttacat tgctgcgcaa actgtccctg ataagtggtt gtgctatcca 673561 tgggacgctg aagatatcga agaacatacc atgctcgcta aggctcaagg tcatgactga 673621 tgacaaacag tatgttgcga tggggttgca tgtatataga tacatatagt tatcattggt 673681 aattatttca tatttaacct aaatctaaag ataagagtgt atttctagtt atctcatttt 673741 tccttgcatt tctaccattt gttgaacttg ttgatgcatc atctctttta aatcggacac 673801 atcattttct aattcctcca cttgttcagt cttttcacct aatagttgta aggaggtttc 673861 caatttactt tgcatctgct caactctttt taagagatca tctttctgtt tatttacctc 673921 attgaattta tcgttttctt ccagaagtct taaaatctca tcatttgctt ttgtcttttc 673981 tttcagtaaa ttatcgtata attcctttga tgctgataat tcaccttcca atctttttaa 674041 ctccgtactt aacttgttca ccagatgagc gcttatgtgg ccgttagaat tcgatagctg 674101 gacgctagct cttctgtatg gtattgatgt gttgtttaac gagttcattg attccccttc 674161 cctgattgct tgtaaagcag cggcctcttc tggaatatcg tcaatgctga aatccacatt 674221 ttttctatca aaatgttggc tttcttcgct acatatggtt tcgtgagatt cattgtaaat 674281 gggttttaga gacggatcgc tttctaattc gccaagtttt gacattgata atgacagcat 674341 agaattttct tgaggtaaag tccattcgtc ttctatattt ccctccatgg agtttaaact 674401 atctgttaat tctacaggta ttttatctat aattttctca ttgctgtttt cttgatgtgg 674461 ttttagttcg ttctcttttt gttccaactg agacctttga atttcgtact tcttcttcag 674521 tagattataa tcatcactta tactttgcaa tgatgacttc aatgtctccg cccgtctctc 674581 caagtctttc acttccaaaa ctgccttcga atgattctct ttttcttttt ctaattgctt 674641 acctaatgtt tcagatgaac gtaaggcagt ttgatatttt tcttcaatat catttttttc 674701 tttcattgta gattcaaagc ggttttccaa gttcacaatt ttagtgttca aagcgtattc 674761 aatactatcc cagttggcct ttgatgactc aagctgttct ttgagccgat tgtattggaa 674821 agatgcgtgt tgtttttctt cataactttg ttggtcatcg acaaaatctc tatttgattt 674881 agcgtctaaa ttttgagtag agctatctaa ttctattctt agttgttcta gtttagtctc 674941 tagagtggta acttgatcaa ctgttgcttc ttgtagtgct ttcttttccg tttgaaattc 675001 acttttttct ttttcaagca atgttctcat attatctaaa gattgctgta aaattgttat 675061 caaatcatct ttttctttta tatttttctc taatgtttca agtgactctt tttgtttatc 675121 tgcatccttt aatttatttg tagcttcagc cagttgtcct tgtatgttgt gatacaatga 675181 ttgcagctca ttatagtttt cgacactctg agcagaacta tcgtttagtt cagatacctc 675241 atactctaag tctttcactt ttgttcttaa agctttgatt tgatttgatt gcctcagctc 675301 agtttccgct aatttagctc cttcttttct caactgatct atcaagtcgt ccttctcttt 675361 aatcaatttg aaaaaactag aatccgtggt ttcgatttgt gattttctgt ttagttcgtt 675421 agttaggtca tcaatctgtt tgtttaatct taaatattca ggactaattt ctttgactaa 675481 ttcttcaaca gtaaattcag tgtaattttt aggtagccat gtaggcagtg ataccatagt 675541 gtcgtcgaag caatcagtcc tattgtgatc gggatgcacc acgtcatcga cagcgattga 675601 atctgcctta cctgtatcgc cttccacagt gctttctgat cgtaccgcag gatcatctat 675661 gttttcagca ttgtcaattg acaccacacc ggcagccgca tcatcaatgg atgtacgagc 675721 actttcttgt tcattgtttg acagcaccac aggcgatgga gacgacaaat ttgacgttga 675781 ccttttattt ttctttcttc ctttcttagt tgccaaggag agtctctctt ccaacgataa 675841 ttttttactc atagcaaaat tggtatacca ctaccataca acacttttta tatactattc 675901 tggactaagg accttttaac gacagtctat taaaagagga agtcaagagc tttttggtga 675961 ataatctacg gttactgcca aattatgatc ttctaaattt tggcgcttta taacatcctc 676021 acaccactac gaagcacact ttgactacga agtattactt aagttagact ggtctcattg 676081 aaatctatta gtttgatgta tttagtccct ggatttgtag agccctcaat tactgttatt 676141 atattagccc taagtaataa tctgtatatt ggtatcgttt tagatgaaaa atcgtttaat 676201 gtcagattca aatcatgctc aattagtctt ttcattaaca gcatgacttc gttcgttaag 676261 ctatctattg attcatcatt atcatccaaa ttcggtacta gataaccctt gagaaagtcc 676321 gccagtgagt cccaaagctc tttatttctg gcttttcgtg ttctaatatg ggcgtgatct 676381 tgcttcttac tgtccataat ggtcatttga tgctgcagtt ttcgtagcag ctctttcaag 676441 tcactattaa tattattctg taacaataac atggcctttt gatcaactga ttgatcattc 676501 ataagcgaga gccattcact ggaactttgg gctctcaaag acaaaaaatt cgatgtcaaa 676561 ctgaaaccaa taggatcagc tctctctgag aagaacatgg gttttcttaa taactctgta 676621 aagacctcag aattgaccgg tttaccctct gtatccagag atctcttcgt gatctcatcg 676681 atggcacctt gagcttgctt caagaaatat cgtttgtttc cgatctggtt ctccaggttc 676741 tttatgtaga catccaggac atccttttca acatccatgt ttcctttgtg agactttctg 676801 ccgtttgctc ttgtccctct ttgtcgtcat atgcgtcttg tttgttgtta cgctgcatat 676861 caaagcgaac ggttagttat taactaacgt aaaaattgat ggaaacattc atttatatga 676921 aagtattgaa gaagaggtaa aaaggaaaac aaatttacaa acaacaaaga atgtcttctc 676981 tatcaacgtc tgatttggcc tcccttgatg acacttccaa aaaggaaatt gctactttct 677041 tggagggaga gaactccaaa caaaaagtcc agatgtcaat ccatcaattc actaatatat 677101 gcttcaaaaa atgtgttgag tctgtcaatg attctaattt aagttcgcaa gaagagcaat 677161 gtttgtctaa ctgtgtgaat cggtttttgg atactaatat caggattgtg aacgggttgc 677221 aaaacacccg ttaatatgaa accgatttat ctctccgagt cattattctc tttaccttaa 677281 tatatctgta aataagcaaa tgaatatttt aatatatgtc caaggtttct ttaaaaggga 677341 ttcttcagca taaagggcaa ataactcttt ttgtttatat actgtctagt tatatatata 677401 tatatatgta tatgcatttg tctgtgtctg tgtctgtttc ctatgagaac tcaaaaagta 677461 actgaaaccg cggttgctta gatagagtcg ataactgttc acccatagcg cagtcacaat 677521 tcagcaacca gcttatcgtt tccttacatt gttgtagtat tgattcgttc aacgcatcct 677581 cttgcgaaca cttatcgtat gtaactagaa ttaatgataa aatgtcgaat ctgtgagcca 677641 ctattctttc attcgggcaa acctttatga gagtacttac cactgaaaga gtttttgaaa 677701 taagttttgg aaaagttgtg taaaaaggat ttcgtacaat atattcacct aaaacaaaaa 677761 tcagcctctg gagatgtaca acagaccctt ctctttgaag tctcagtatg ttcattgtgc 677821 attccaatgc gtataacgtc aaattttcgt atgcaaggct agccctagga attatgtttt 677881 gcaagattat ctctgacatg aacttttcca ggtgatattg atactttgtg taattgtcca 677941 aaaattctac tttatataac gactgtatcg ttgggaaaac gacccgccat atggctattg 678001 tttcatcagc attgtatgag ggagggagaa aatagcacat attgattagc gtcttttcga 678061 acagtggaaa taaaccagta ctagagaact gtatccattt tgagtcattg gtttcgttca 678121 taaaggtatg atttaatagc gtctgtagga gcagaacacc acgaagttta attcttctta 678181 tatcagtggt atcatctagt atgtttagaa ttcctggaat aatccaagaa agattcgtag 678241 atatgtctct ccttttcaaa tgtaacagaa ttacgtagaa taacggaatg cctttcaagc 678301 caccctgact tacccacgcc tgcattaggt tatcttcttt caaagacatt ccaagcgtgg 678361 gtttgagacc aagattacgt tgctctttga gttcgaagtt gcttttgcgt tttaaaagta 678421 gtggctgtaa cttagaaata aggacgcaca taatttcgtc atgttcactt ttgttacgct 678481 gaaagtagta atctatagtc tgcaaaacat ctgtgttgat ttgtatgtct actcctggag 678541 atatggagtg atatgagaga gattcaataa ggttgacctc atcggacacc gtaattgcac 678601 atccagtatc tgtcttcttt cgtaactgga gacacaactc tcgaagcctt gtagaagaaa 678661 gactcgaatc attcaattca tcgatgatat cagttacggc cgtcattctt ttcaatattt 678721 tgttatatga ttttattctt cacctcgttt tcattcttca tagttttcgt ttctcatctg 678781 ctattgaaaa accgaactag ccgaaggata acaataatga gtcttaactg ttaatataca 678841 agattataca aataaatatg tttctataaa ataaaaagtt atattcaatt gcgaaaaaaa 678901 taaataaatg tgggaagaaa acccaatagt atgtcctact atgtcatatg ctatcattaa 678961 taggcatctt cagacacatc ttcatggaag tatttaccct cggtggttgg tttaatgata 679021 cctactctta tacagaaatc accaaagtgt tccccttctt ctctttctaa agcatacctt 679081 ttaaacaatg gtttgatgta gtcgacaatt tcctcatcct tcacattggc cttatacaat 679141 ttgtttagcc tttggccgag gtaaccacca ccaagcatca agttataagt atgtggagct 679201 ttaccaacaa gagctaattc acctagccat ggacgagaac aaccgttagg gcaaccagtc 679261 attctcataa taatggaatc atggcgtaaa ccatactctt ctaaacaatc ttccaactga 679321 gtaataatgt caggtaggaa acgttcagat tcggcaaacg ctaaaccaca tgttggcaaa 679381 ccaacacagg aagatgaaga taatctcaaa ccgctgaaat cggtgttatc caatttatag 679441 gtctttaaaa tagattttat tccagcaaca tgttcatctg taatattaga gataaccaaa 679501 tgttgattac cagtcaatct gaaatgacca gaattagtct taagcatgta ttcagcaacc 679561 tttctaatac ctgtcttttg aggcaaatct ggtgtatctt caaccctacc attttcaata 679621 aatgcggtaa agtggtttaa cccagtttca tctttaatcc atccaaagta atcaatatta 679681 gatttaaact caaatggtct ctcaggctcg aatttcttac cccagtattc ctccactttt 679741 tgcttgaagc cttcgacacc catatcatct acagtatact ttaaacgagc atgcttacgg 679801 tctttacggt caccgtgatc tctttggaca ataacgatac cttcaagtgg tggaataatg 679861 tcttcagttt taacaaaacc taagcatgac cctaatcttg ggtaagtttt cttgttgtta 679921 tgagtggtac ccataccacc accaacaaaa acattataac cctccacgat ttgagtttct 679981 gggttaacta tagcaactaa accgacatcg atagataata catccacatc gttatatgga 680041 ggaacggcga tgttgaattt aaactttctt ggcagataag ttggaccgta aattggttca 680101 atatcgacca aagcgttacc gctaactaga gtcttctttt ttcttggacc atcttttctg 680161 ttttcaaaaa tagatggcca ggatggatca tcgtcctgtt cttctgggcc ctccagccaa 680221 acttcgtggt aggccgtagt ctttggtaag aaatgatcag aaatcaattt tcccatatca 680281 gcgatttgtt ggtgaacctt ggcattggtt ggtagagcag aaaccatgac atttctgttc 680341 acgtcacctg cagcagctaa tgtatccata agaactgcat tcattcctct caatgtgtgt 680401 ttcaagttct tctttagcac accatgaatc tggaaggttg cccttgttgt taatttcagg 680461 gtaccattgc ctgaagtatc agataagtga tccagagcaa gccattgttg tggagtggtc 680521 ttaccacctg gtaaacgagc tcttgccata aacatatagt atggctctaa gccttgtgac 680581 ttacgtattt ctctaatgtc acgatcgtct tgggtgtaaa taccgtgaaa tttcattaat 680641 tgttcattag cgtgagtaac accacctgaa gaagtatcct ttaagttctc actgatagta 680701 cctctcaaga aattagattc tctcttaata tcctcgtttg taacaggttt tggctcatca 680761 tcaacagcag cgccggaaac accaagagct tcccataatt taggttccca ctcagaataa 680821 gcagtttgga aaccatcagc atcttgatca tcacccagtc ccaagggaat tagggctttg 680881 gcactcaata attccaagcg cttaaataaa tcctgtgaag gcttgttaaa ataatgttta 680941 tcttctttac gtggccaata ctcagaatca ccgagaccaa aaacagcaac attcaaacta 681001 gctaaatcca agtcggtgtc atttttcaga gcttcccaga aagacttacc gtcttggggg 681061 aattcacctt gcccagccgt ggaagtaatg aaaactacat tctcttcacc aggtaattct 681121 tccaaaataa tgtcatccat ggacagaaca gtagccttta aacctcttgc agatgccctt 681181 gctgctagtc tctttgccaa gtttgcagca ttaccaccgt cagaagcata atagacgtgt 681241 agcggtgggc cggacaaacc ctccaataac tgatcgaagg cagccttgct tcttttttct 681301 tgtttccttg tcaacgcatc accagcagat tgctttagat ttcttgacaa agatggatct 681361 tttctggtta atagggtaag cttattctca cggtctaaga agtcctgtaa ttgttttctg 681421 ataaccgaag aatccaagct aaatgcctcc ttatctgttg atggatcgtc ataaacagga 681481 ttaaacctat acaatggcca gtaaccagat tcaacggcgt ttttggtttc ctttaagact 681541 tctaatggag tatcattttc ggaattatac ggcaaataag ccaagacaat agaaggacca 681601 ttgtatttag atgcctctat tattgcagtc aatagttggg tgtaagaagc atatactgct 681661 acagaggcaa cataggcact gtaataattc atggcgtaca aaccaacatc tttctttcta 681721 tcctggtttt gctttctatg gtcatatggc tctgaatcaa tcaataaaac attaatgttt 681781 ttacgggagg ataaaacctg ttgaatacct gagtgaccca aatcataaga ccaggcatcg 681841 gagccaatta gccagcttga tttgaaaata aaagaatcgc ttgttggagc tatctttaag 681901 aattttaaga cagtagagga atcttgatta gattgtaata actgaaatat ttccaaacct 681961 gtcgcattgg cctcttgtaa ttgagcttcg tcaagatcgc gtccattgaa tgacaaccat 682021 ttagataata gttgaacaat tttatttgca tcctcggaca agtaaagact tggatcaaga 682081 gaggtttttg ctaagctgat caattcttca cgctgggctt cttgttttaa aaagcgtcca 682141 aaaccaaatt ctggattact tggttcaatt gtctcactgg aaaattgatt caaaatttgt 682201 agatttgatg aaaataactg ttttagcact ttgatatagg cgtcttctaa gttcacaact 682261 tttttgacag aagaaataag ttgagtaact tcagcttgtt cctcagcctt ttcattggat 682321 tcacctaaaa ataagttatt atctggttcc ttcttgttaa tattcgatat gacggtgttg 682381 ataacgttgc cataatcatt cacattacca atattagtca acactacctg ctcgatgttc 682441 ctagaaacta attcattaaa attgccaaag aagtccaaaa gaaatggttg aaattcgttt 682501 gattgcgatt tcttagagac accctgtaaa acggcgattt tggtaacaga agatggcagt 682561 atttccaaga acttggaaaa attccatggt ctgtatactc taatcttgat caatcctacg 682621 tttgaaggca atacgctact gaattccgcg tcatatggtg acaggttaac aatgacagtg 682681 gtaattgact ctttaccttt aaccagttca aaatttgtca atgaatcagt agcttctgat 682741 aatgctactt tagtctcttc gttagcaatc tccaaggtag gaaagtcgat gtcttgttca 682801 atagctgtac tcgtgccaat tttctccaag ttaagaaaat ggaaaactgg ggtcagagaa 682861 cttgtagcaa tcttataaga agagtccgcg tttgaaattg cagtttgcaa atcagaagat 682921 attaagatgg ggaaagaaag atcctttaac gcaggaattg cggaataatc ttgcaaattc 682981 aaatccactg taatcaccaa tggaagttta ttaggaagag aatatagatg gtggatggat 683041 ttgaccaaag tagtttcatc tgtaaaaacg gtagttaaaa tgtccttaga gagttgatct 683101 ttgatggtat tcaatggatc ttgattgttc aatagatgag tagcatctgt ggcaacagat 683161 tctagccctt tgaaggatga atgactattt tttgtgctag tagtgtagaa cactttattt 683221 tggggagcac tagaggaata ttgcgccaac aattgtggga gcgtcaagag gtcagaagca 683281 gtcattcgcc aatcttttgt ttttctctgg ttcccgttcc ctactgttac tttattagta 683341 tataagggat ctgaataaat atcaagacga tggaaaaaaa ataacaagca aaggaacctt 683401 tctatatccc aattttattt cacattaaaa actatcgtct tccaacactt tatataactg 683461 cttgcagcgg ccagtaattc gtcgcatctc catgactcaa attttccagt gtctcttagc 683521 agttaaacca ttcctgcctc tgtgtggtgg taattgtggc attatgagtt aagagataat 683581 acgcacgtga tgaaattcat tctgtgaaat atcacgtgga caaattatat tacccggatt 683641 cataaatcca cgtattttac ctgcatcttt attgagtgct tagtaaaagt cagttggtga 683701 aattccgcag ataaaacagc atattagttg cctgaaaata gccttatgtg ttggtttgat 683761 acgtctttgt cattatatac ccaaaggttt gtagttcatg ttgcgggttg gtatgaataa 683821 atttttcgta tttagtgatt ataatactta ttacccattt cggcggctaa taaggaatct 683881 gctaagatag gtaaatgtac aataccatca atggcttcta aaagttttca aagaagtggg 683941 ataagggatg aaagttgtgc gtgtgttggt tacttaggtt ctaatttggc ttcaatttga 684001 agtgagatgt tttgtttaac attagtttca aattaacagc ttttgtgaga aaatatattt 684061 tggatgaata gcagaaaata gaaatctgga aataaacaaa acagagccaa aattctaagc 684121 ttaataacat gaatatttgt ttatctagca tcttgttcct cccactcttt ttccgaaaat 684181 atggctagcc aacttaggtg aatggggaag ggtactagat tcattcattt atttctattc 684241 aaggacaaga acttttaaca tagtaagacc tttatgttag tttggtgcgg ctgacaaatt 684301 catagctaat gtgctagagc tcttatattg gtaattacta atccttcatt gctattatga 684361 ctatcacatt ataaggtaat gaaaaattaa atcattgtgt acggattaag tcctttctct 684421 aaaagagatc acgtgactat ttgaatcact atctatgtta atcattattg tttaaaagat 684481 agtaagtgac agaacaacga attgtttctg taactacttt ttaagcaggg aaataactca 684541 gcactgacaa gggacacttt ttaaggatgt tcgctaaatt gcatgggaag aaacaaagac 684601 caatttcttc catcaattca caaactccaa ggactagcaa tactactcac gcaaatagca 684661 tatccttatc atcgggtaat ttgatagtag gttccaatag aaatttaaga caaaagaaag 684721 agcagtttgg ttctcaacaa agggcttccg gcagaaagct gatttcaaat aaggaaaatg 684781 acgataacgt caacaatggt ggtgacaaca attatgacaa tggggaacgg gtccatcgcc 684841 atcatattcc aggactgaaa ataaaggcgt atcaagctga attaggctat catgagtccc 684901 gattttccga gaatttagtg atgctaaatc tagttgagtt cccggatata aaacctggtg 684961 atttggtaga attgaaaaca tatcacaaaa atccatctgc atcgaacgga gataagaaaa 685021 tttattttat tgcaaaagat tttgacggag agactaaaag aagggcaaaa acatctaatg 685081 tttcaatact ttcgggtcaa ctgcaaactt tgttagattt gccttctagg tctaggatat 685141 ggataaaatt gaaaccaaac aaatttgact tacaggcaga tgtggtagag tttaatatca 685201 aagattgcct actaaataga ggtgatatgt gggttctatc atctaagctg gtagatacat 685261 gtgtgtttat ggatcaaaga ctggcattct tagactctat cagaggtact attaagggaa 685321 tttatcgaaa tggtaagaag attgtttctg gatatattgg cgaacaaaca aggataattt 685381 ttcggtccga atctgccaga ttaatttttt tgattcaaat aactgatgaa atgtggaact 685441 tcgaagaaac tggtgaacaa ttatttcaaa agatggttaa ttcatttttc ccgaagatct 685501 tcaaaaaatg gaaagatgtg gacacccacc atactatcac tatagccttc gctatatcaa 685561 tggacttgtc tgatacatca ttcaaggact taacacccgg cgaatctttg aaaaattcac 685621 aggattattt taggatagtt gtagatcaag tcagtattat ccattgggtt gatattatgg 685681 aaacattaag agaagaattt atggaaatca gaaaagattt attaaacaag caaacggata 685741 agggttacag tgtagcgaat ggaagatttt cacctgtaat caagtcgaat tttctcgaat 685801 tggtcaattt tgccacgaca attttaacgg atcctttcaa gcaattagat cttcgacaca 685861 ctacaacgca cgtcatgatt atttcaccag ggtctggatt atttgacgtt gattatagtt 685921 tattaaggct aacaggaaaa aaactactct ctcttgaaat gacgatggat ttaatatgtc 685981 tttcaaaagc tccattgcac atagttccac tttttaggta ccgagacttt gagaacaagc 686041 ttcatcattg tgtaccgctt tggttaagtg ttttcttttg gaatgatcat gacaaaaaga 686101 gtaactcaga atggactcca agatgtaaaa tttatgactt acaaatgatg gggattactg 686161 aaaatgagtt aattcgggaa gtggatgttg aatatttaca gctgaacaag aaagtcaaat 686221 cactatccga gtttatgaat gattacgaca aaaatgcctt cgaggtgaaa attttatgcg 686281 ctggctctaa tacgaaacaa tctaagaaat taaattcaaa gtttgatacc gtcttcgaga 686341 atgatgttgt tgtgaaggca aggaaaatcc cggcaacagc aacaacaaca cacggtaaca 686401 caaaattcat atggagaggt ccaaaagttg ctctcccagc cattaaggat attcaaaaac 686461 caaacgtaat accagatcta tcaataaaaa caatagaggc ctctttttat gatgattgta 686521 atactacaaa tgataaaatt agcactccca ccacttctaa caatgacaat ctcgaaatga 686581 atgactcatt ggtctctgtg agatctgctg ataaccaaaa cacatctttg gcgctggatt 686641 cgctcaaagg actaagcaaa aggaactcat tgaaagattt tactcaaaga gtaattacaa 686701 aatttatttc gaacatagac acaagtaaaa ataaaaaaat aaagtcaaca ttactcagag 686761 atgatgtgga taactcacct ttaggttcaa atacaccact accatcttct gaaagtaaaa 686821 taagtggcct gaaattacaa caaaaaggcc tggcagatga aaacgttatc agtaaacgtg 686881 gaaatttgat aataaagaaa aacctatcca tttttgggct acctagtaat gaaatcatga 686941 gtggttcacc ctcctcatat ttaggctcat cacataccag aacatcctct aaactttcta 687001 atatgtcaga caaggctgct ttcattacag aagggcaaaa atcaaaacat gatgactcga 687061 acacttatag cctcacacag caattgaaac atcgtataag tgaaacttgg gtggatatta 687121 aaagtccttc cattccggta agtagtgaat ttgccaacga attattgcct atacgttgga 687181 aagatgtatg gccaaaatat gtggccagaa aatatagtaa atggaggtct tttacaaccc 687241 cagcagagtt accaatcaca atttctgatt ttccatccaa ggatgatttt gataggaact 687301 tcatcttcag aaatcactca gtgactttaa acacagatca agaacaatat aatcagacat 687361 acaaagactt acttcgtgat atgatttata tgcgactgtt aactggtttt caaatctgcg 687421 tgggccgaca agtagaaaaa atagaacttt ctagggaaag tggtgaaagt gaaactgtag 687481 tcaacaagta tttagatttc aatcaaaatg atgcgttcaa actttatcta atgatcgact 687541 ctgaaataca cagaataaca tgctcgtcaa gtggaattat tgatgtggag aggtatttga 687601 gaaaagatga agcaaacttg tttgatcagg ttcctagtta tattccgttg gttaaaacga 687661 gatacgagag ctcatttcgt gatgctatga ttgacccact tcatgttaaa agagaatctt 687721 tgaactggaa tcaaattgat caggttctag caggttatgg cgataactta atagatagga 687781 aatggcacgg atttcgagct aaatatgtgg tgttaccaac agatatccct cccaacacat 687841 attctatggt tatcaatggt aaaagcgaaa ctttaaaccc agaagaaatc agagtcgagg 687901 gtttgagaag attaattggc tcaataacga ggtcaagact aagaacagag aaagaaaaaa 687961 aaggaagaaa aactaagaga gaagaaatac agcctgaagt tatgttttac accggcccgc 688021 tttacaactt cattaatgag caacaaacat ctttagaaag ctcggctata aattttaaag 688081 attcaatttt tgttaatgat aataaccttt taaacagaaa tgtagaacta tccaagttgg 688141 cgtatcaaat tcaacgtggc gaagatcgca ttactttagt caacagaaaa tggcactgga 688201 aaaagcatga aaagtgtttt gttggctcgg agatggttaa ttggctcata agaaacttct 688261 ctgatataga tactcgagaa gatgcaatta aatatgggca gaaggtgatg aaagagggat 688321 tatttgttca cgttttaaat aagcacaatt ttttggacgg gcactacttt taccagttct 688381 cacctgaata cgtaatggac actaataaac tagaaaaaac aaactcccat cgctctacat 688441 tatccgatcc aaagcagatg ttgagaaaag catccactgg tagctcaaac gatccaagcg 688501 ctatgactcc tttttcttca gtagtacctg ctataagcgc ttcgaatgct tcagttgctg 688561 acgccaaaga gccatcacgc cctattttaa tgctgagtaa ctctcttgtt atcgatgttg 688621 atcccgcggg aaaatcctcg aaacaagaat cgtgtacagt ccattatgac agagttcata 688681 accccgacca ctgttttcac ataagattgg aatggttgac taccacccca aaattgatcg 688741 atgatttggt tgggaactgg tcaaggttat gcgaaaggta cggtttgaaa atgattgaaa 688801 ttccttggga agaactttgt actatccctt cggtcaatcc atttcactct tttgtggaaa 688861 ttaagttagc tatcaatcct tgggaagatc ctgagttcaa ggatagggag cttttcgcta 688921 aaagcaaatt ctactaccac gtttatcttt taaaggcatc tgggttttta ttagacaata 688981 gggcatccaa atttttacaa aatcaagata tagagtttga catcatgtat tcatggggca 689041 aaccacagtt caaatatgtt caatatattc atcatacggg tgcttacgtc gcggaattga 689101 gggaaaatgg ctgcctattt ttagctccta acaacattta tatatccaga gtgaatccgg 689161 gaaacataat cgggaaaatt cattctgctt caagctcttc attagatgct caaaaagtga 689221 tcctaaattt caaatcaact tgcttggact atcagaagtt aaggtcaatt ttccttgacg 689281 caaaggaaat gtggattaca ggaaagattg tagaagattg agtagcccca tgacatggat 689341 gagtttcttc acaaagtaaa taatattcga acgtggatag taaagcataa tgttatctat 689401 ttatatataa atatacctat gtttttatat gtctgtttac tgatctaaag tctttgagca 689461 atcttgataa catcacccaa aacaccagcg gcagtaacgg cagcaccggc accggcacct 689521 tgaatgacaa caggattggt gtaacgctta gtcttgatgg aaataacgtt atctgatccc 689581 ttcaatgatg cgaatgggtg tgagtaatcg tacttttcaa ttcctacaga cacagatttg 689641 gtggcaacat cgactttacc aatgaatctc aataccttat tttcagtggc agcttccttc 689701 ttcaattgag tcaaatcttt atcgtaatca gataattttt ccaagaattc atcagcagac 689761 ttgacagatt ccaatggttt tggaatcaaa gactggacag ggaaggaagt tggagattca 689821 acttccacac cagatatcct accaacaatg gtaacctttc tagcaacatc caacccattc 689881 aaatcatctc ttggatctgg ttcagtataa cccaattttt tagcaacttt gacaacatca 689941 gagaatttga cgtcgttagc ttgactagtg gagaactcgt tgaaaatata agatagagta 690001 ccagagaaga taccttcaat tttttcaact tcgtcaccgg tttgaataat ttctcttaag 690061 aaactgatga taggcaaacc agcaccgacg gtagcttcat gatagacaaa accgttagtt 690121 ggcttatttg agaaaagagc cttccaggta gccaaatcag aggaaaaggc cttcttgttt 690181 ggagtagcaa tggaaatacc attttcgaca aacttagtgt aaaaaccagc aatgtaagcg 690241 ctggaagtgt tatcaaccaa aatgactggc ttaggtgaag tcttcaaatg agcaattaaa 690301 tcatccaaag gcaacgtttt agtagtggag gctgctaaag cagccttcca atcagaacca 690361 acatttaatg gagaaaagtc cttggagatt aaagaacgct cagcttcagc caaaagaact 690421 agattgtaag taatggtaga cttcatggct aacaattgat ccaagaaagc tgaaccaaca 690481 acaccggcac cgataacggc aacattaaca actttagtgc tcattttttt tttattattc 690541 gattgatgat actatctacg ttcttaaaac agtcctgagt acacacacag aagatttagc 690601 ttcaacaaat tgtctatcgc taaccgcaat atttacatat tctttataca tttctgttcc 690661 attcaaccca actttaccac cagggcacac ttcttccaaa atatggtcat caacacaccc 690721 gtacaccacc atgtgcgtta ttgaaaaact cacgtgatct tatccactaa tagcctcact 690781 ctatcgaaga cttccttctt tgtaacacgt ttcttaattg cacttggctt agaagtaggg 690841 tctggagtgc tttttgatgt cacagaacct gatgacggta gtgctggatt gttttcatcg 690901 ttcacgtctg tgagggattg atcctgtcga gctagaggaa aatagagata ctcgaaataa 690961 atgcccaagc aaacgctgtc aaatgcaatt ccgctatgtc cctttttcaa ctggaaagca 691021 agttttaacc cggatgatat ttcttcaggg tactttcctt ggtcgaaaac ttggttcagt 691081 tgctcactaa tcttcaggaa ttcttggtag ttcaaggttg gaaggatttg ctccacgtag 691141 ctcttgtctt gcaattgcag cttgattttg gcactttgcg tgtacacatt aatggcacgc 691201 tctaatagtt cgtttacgtt cacagttcca gaaccaaatc gccttagctt ttttataaca 691261 agacctgttg tattgaagtc ttttattgcg aagagtaaat ccaaatacaa aaccaggtac 691321 tggtaagtat agatgaaatg tttccctggc ctttcaaaat ctggtttcca tatattgacc 691381 aagtttttgt ttatactttt tgcggatatt aagctatcca tctcctccaa agcaccgttc 691441 acatcaccca aatcgtcaaa caatatgcgc gctattctgt aacgaggtct gtgctgccat 691501 ttttttttat caacagatag taaatggcga agtagtctta tgattttgtc aaaaaagaat 691561 ttttcttgat aatcccatgc aagaccttcg tcgttgaccc aaaattcctc ttgttcctgg 691621 aagaattggt tatctttaga cagtaaggtc agagcttcgt taacacctat gacgcctctt 691681 tttacccact tgtaacaagc attaactaac agataatggg gttctatgat cggatcttta 691741 gcaggtgatg actcataagc tatttggcaa ccctgagtaa tatatttggc aactaattta 691801 caattattac caccatctgt tttgaaaaag aacttggcca gattgtaaaa actagaccaa 691861 ttcaacacga atacatcgtc ctgtgacttg atatcgccgg ataaagaaca agccctatta 691921 aaacataaaa atatactttg ctcgatgtta aagtctgaga ttgtggtgat tttcttagtt 691981 ttttccatta ctacttcacc ggtttcagac aatctcattg tattctcagc actgcttttc 692041 cagctaaaac aaagcttatt catgggatta tagtagccgc taatcagcat agatcctaag 692101 tcatccaatg cctccaatat aatcttttta tcgtcaatag ttcgatccaa cttactataa 692161 taaatggaaa tggccattaa ataacacaat attgcctttc tttgagtcaa agcaataaca 692221 tcttttttct cagggacagt gatcttatct gaggtccata ttaaatcatc ttcaacaata 692281 taactgtaac actttccgag taatatccaa ctttcgaaac ggtttgtgtt gtatataatg 692341 tcattcttta acattctgat aatggagtct aattcagaag gtcttgcttg catagacttc 692401 tttctcattt tatacaaacc cagggactgt aagctggata cgtagaacaa gccggctgtc 692461 atgccttgct gtaactcgtc gtttggagaa gttaaataca aacttgttgc accagaaaat 692521 gtatgcttca acaagtctgc cgttattggc cttgataaat attcatttaa tagaaatgag 692581 tttctagata tgatatgatt gtccagcgtt gatgggtcgc caattttttc tataatatta 692641 tccattatct gttttagggt ggtctttgac gacgacaggt aagggttctt attttgatac 692701 tgtaatttga ttagatatgt acctaaaggc aaagagtgta tcttttccat ctctaccgct 692761 tttgtatcat gcagatcagg actgaagtta tcactagcta tcgcgtagtg atatctacac 692821 cacagtattt gcttcaattg taaaaaagaa tcattattaa tgaactggca caatagtttt 692881 tcagctaaat ctaggaactt tccatttgat gcatcacaaa aatggaaatg tccaaaaaga 692941 gtgtgtaagg accaaattag ttccgttgtt tcaatacctt gttcagcagg tgtcctgagc 693001 tttgcttgta aatcataata ataaagtatc aacgtcgcta aatctatcat tatatccttc 693061 attttccctg atgatttcga tgctcttttg aaaaaagact tattagaaac gtcgttaacc 693121 gcagagcttt catagaaaag gacagtataa aagaagaaga atgtttgcag cagcttttca 693181 aacatatagt cctccaagac aaaatcgctg ctttcccacc tatttgaatt tagtatcgct 693241 gtcagttggc ttgagagata gccaattgct gtcaacactg ttaataacat ttggtgcctt 693301 ccgtgtgggt tcgattcttt gtagacaggt gacgtcaatg cgcccttcat aaaatcaagt 693361 acgtggaaat aaattctttg aacatcctgt atactggatt ttttgacata tgacgaaaag 693421 agaacgcccc aaagtctaat tttcaataaa aatggtgagt tgaaaataaa ggaaaccatc 693481 tcctcatcaa tatttgaatg attagtcgaa gggtgtaata tatgtaaaag gactttttct 693541 agtgtctcta gatgattttc tgaatgagtg tcagagttcg tgtcttcaga tatatcttcg 693601 actgttatgt tttgtattat tcttattttc cttttctggg attgaactgt gtttaggttt 693661 agtgccggta tatgacggta attcggatag gcaatgtcta aagaagaatc tgaatccttt 693721 atagtatttt ctaaagacgt caaagtttca gagagtctgc tatcgactat atcacatgta 693781 tattgcaaga agcagtaatg cgtccattga aaatgtacat acagttcttt atctttttcg 693841 tcagcaattt gttctaacag agtatgccac gaccttattc ttttctcgac tttatttctt 693901 tgacttttta ggtctgctga cttatgtcct tgaatccgtt tatttgtgat ttcctccaca 693961 atattcccta aatggttaac aagaagttcg taaatcgata aagccaaata tttgcattgc 694021 cttttgtttt tgttaataag tgcaaaaatg ttcgattcga ttccaaatac aaaccataaa 694081 acaattttta gaagctgaga ctcccaaagg tagtctataa tgagacgcct tccgtttcct 694141 tcatcgtaag ttccaagcaa tttgaataat aatttcaaac gcacttgatg gaagtgaaga 694201 ttgcctgcat tcacttcgga aataaaagat ctgatgtgat ccgagtccaa atcatttaaa 694261 tatctaggaa agctctcctt atcatcaaat gcattagatt tcaggagcgc atttagttgg 694321 aataattcct cattttcgtt agaaccactg gacaagtagt cattttggtt aaaaatatca 694381 gtatatctac tactccaaga tttcaaacat tcatagagat cagtataggg aataaatttt 694441 tcgggttgtt tgtcactaga gccaatgata aatttggaag caaatgtgtc aaaatcgcaa 694501 aagggtagaa tgtgaatata tgacaacaac gtgttgaact caccaaaaaa tcttttatga 694561 acgtccataa caagctcttt tgagttttct tgttctcttt ctttaaagcg tttactactt 694621 ctttgaagag gcttcgtgct atcgatatgt tcatcagttc tcttgttagg ccttgcttct 694681 tcattagttt ggatatccga tggagctaaa ttcccactct tatcatctgc tcgtacactc 694741 tcattatctt gctcttcttc ttgtcgctca gactctctat ctaaagatgg tgtattatta 694801 attgcttccg atagttcaaa cttaaccgct tcaataggtt cttcaatttc gttatacgga 694861 tccatattcc ttccaataag agacgatgtt ttaacgctgg gtagtaagtt tttcaaagcc 694921 ttcgcaactt catcccatga ttcttcattc aaagtgacat taaacacgtc cagctttttc 694981 attatttcct catcttgctt tttcatttct gatattctag aaagaattgg accaaaagct 695041 agtggttccg gcttaatatc tttgtacttc tccaaatgat atctctcaaa gattgtgtta 695101 tccgataagt tggggactaa tagtttgttc gtgagttcta cgtagttatt catcatcaga 695161 gtcaaatcgt tcaaaagaaa tttacgatgt cgccccaaca aaagtgaaag attttcctgc 695221 ttagtgaatt catattctga tattaaacgt tccaacttga cactattaaa gctcttgaag 695281 atgcgagcca gcaaatctgt aactgcaaaa tcagcatcgc tatgttgaat agactcaacc 695341 aagttctcaa ctgcttttaa aatacaatta actagttctt gtgagttcaa cctttcatag 695401 ttattctcca aatacagatg atagtacatc cctctgttcc tataacatag atatcgcagg 695461 ttatctagcg taggagaaga attgcgatac atgccccacc tatcaggctt gacgacatca 695521 atctggaaga gctcttggaa tttgctgtcc gacttttcga agtccttgtt ttttagatca 695581 atcagagcgt cctgcaaaat attaaaactc tgttctattt gaagctctct tgaatgctcc 695641 tctgcttcat attgttcacc ttcgatgttt gaattgaggg cattgaacat agacataata 695701 agctttatct agaatctgtg ttgaggttct aactccttaa agtgccttta cggacctgcc 695761 ttgctaccgt ctatttgtat ttctgctctt cccaacgtaa acaattcaat aaataatttc 695821 gcgatggcac atagtaacaa gctgttaaat cgaagtaaag aaaaggaaag tcaagaaaac 695881 aaagagagaa acaaatgcaa gggtgatggt tcaatatgtg gtagaatggt taccaaggat 695941 acagagcatt tcagtggtag tagaaggttg gaagcaggtg gagataaaga acttgaagga 696001 cacactcatg agcatatctg gtgatgaaga acaagttgaa gatattttac ttccagtaga 696061 agttgaagaa aaagtagacg cttcttacaa gttcaaaaac agaggtaaag acttagaatg 696121 gatgacgaag ttaagaagca aatcctctaa gatatatgac agttctatca tgtcgcttcc 696181 agatggaaga tggactaaag aagagcttcg ctcagattct gatttctcga tagaatgtct 696241 taactgtaag caaaaaatta taagcaaaga taactgtcaa gttttgaatg atatgccttc 696301 agagttttgg ttcgagttaa tggattattg gcattgccac aaacccgatg ttaaggaaga 696361 caagtcttcc tacacaagat ttgaaacgct aaaaccatct aaaaacgaaa ttttaattgg 696421 aagctcttat tttcaaggca ctcctgcgac ttttgaaaat gtagcgacta caaaggaaaa 696481 tgataatgtt ttatgcataa agtgctcagc agtgttaggc caagtaactg ctggttcgct 696541 ttataaacta cacaaatgga aactgcagtt aatacgcagt ggaaacacat acaaatttcc 696601 tccagaatgt gacattacaa tttctttaat aaacgtagtt aaggcaaact cttgtcgtta 696661 cgtactagta aaatgtaaaa cggaatcatt gctagtttgg atattttccg ttgacattgg 696721 agtcacattg acgggaaaca aaagcttcaa gagagcgatg aagttgcttt acacaaacag 696781 cgttaccaca ataaatcgat gtctcaatcg acaagtcgtc gaggaattag atttccaaga 696841 aacatcgttt aatgcttttt acagcgccct tcaacatact aatgcacttt taccctcaag 696901 catgaaaaaa attggtgaat ggaccattag ctatacatca ctaatctaat tttaagaacc 696961 attctctttc aaatttgtac aaatattgtc atcaagtaat aaatagcttc tttttttttt 697021 taacatacag ttgtagaatt aacttcgttg gccgaagaat tgcacaacaa tagcgtttgt 697081 tatattacta aatatagggg ctttcttggg aacgaaagtg aaacaaacgc ttttaataca 697141 atgaaggtcg agaaatcatc taaaggcttg gaagttttag tgaggacaca ggaggatgat 697201 ctagaggggt tctctttcct ggagattatg gaccgcgtag accctttacc attagacttc 697261 gagaattaca aaaatttcaa agagggcatt tactatatgt gtacacacga tggcacaaag 697321 atcggtttcg tgttgaaatt tgcgataaat gaaatggaga ctgtttgctc ggaaatcttc 697381 gaagaaacct tccaattaga tgaatctaga catgagttaa ggtttaaaag tgaagatttt 697441 gatcatagaa acaatctaat tgaccaattg gctcgtaaaa tgtatttaga atcatccttg 697501 agtggtgtga agggctggag aaacgagaaa tatgccgttt gggttaataa aaaaccctat 697561 gtactggttg agcgtgcagt agcaggtgtt cttggtataa ttacctacgg gattcatatt 697621 aatggttatg tgctagatcc aaagtcaaaa aaagttcagt tttgggttcc aagaagatct 697681 aaaacgaaac aaacatggcc gctaatgctt gacaacatta tcgccggggg attaggttat 697741 ccttatggta tctatgaaac agttttgaaa gaaagcatgg aggaagccaa tctagaaaag 697801 agtgttattg aggataacat taaagcaact ggttcagttt cctaccttta ctttacgggt 697861 gatatttctg taacgaagtt caataaggaa tcagatttta tcgtagggga agtacaatat 697921 gtatacgatc taaaactcag cgaagacatc attccaaaac caaacgatgg tgaagtcgag 697981 agtttcaatt tattcagcct gcaagagacg attaatgctt taagaaaaaa agagttcaaa 698041 ccaaattgtg cattggtaat ggtagatttc ttgattagac atggctacat cactccagaa 698101 aatgagccca attatcttga actagtaact agaatgcaca gaaggttacc attccccacc 698161 ttgaattaac attcaagagg ttaccggttg atatctaaac aaatataaag aatttttttc 698221 atatatacac atctaggtac atactatcta agatcaaaag tactctattt tgtcactaaa 698281 cggaggaagg cgttcagttc gtttgtggtt agtgaacaga aaaagttact tggagaaatt 698341 taattctatg tcaaaccact ctctagaaac aacttccgat ggtgacaagc tgacatctcc 698401 atacactagt ggtgaaaagt atacaaaaaa ccacgcaaca gcacaggaga cacacaccaa 698461 gaagacggta tagggtttaa cgtagacctt agggttccgt tcatatgatg cacctgaaat 698521 atcctcgtct ttctccaaat ccaatgattt gcaatcactg aaaattactt cccatagtgc 698581 tcctgagaat aagcacgcga ttaaatgagc tggtaagtaa tgatgcaaaa acttttgacg 698641 cgccattaaa aagaatggaa aataatgaca gcaccaggag acgaagaaaa acatcaatgg 698701 gccatacagc ttttctctgg tcatcttgtt tagggcataa tagccacgat gtctagtaat 698761 taaatcggcc acgataatgc caacaaaaac agccaatgat atgacttgga accaccaccc 698821 aatgatgtta ccaatgaaat atatttgctt cttttcgtca ccgttggtcc agaacgaaac 698881 accacttaaa ctaccgggcc aactgtaagg ttcagaggca aatggatgct ctgatgatag 698941 tttattgtta tgttcgaaca tagatttttg agtttcaatc catttcttca agaatggtaa 699001 tggcttaaca accttcggaa tatatacctt ccgaacctcg tccaggttaa caatttcatc 699061 aacaacccag ttatttgaag gatcaataac ttttttgtta ccattaattt cttgttgttg 699121 gaacccccaa tccggtaaca actcgtcgtt gtgagtccac aaagctacgg aggtatcaac 699181 gtggaaaaga cggaaagaaa ccgttttact ctttaaaacg tgaccttcat ctgatttttt 699241 cagtggttgg aatgcaaaaa gtgtttcagg atataattcc ccatcacctt cttctaaagt 699301 tactgtagtg atttcttcat tggtagggta aaatggggag gcgacatcat gggctaacaa 699361 gtaggtatcg gtggctacat gtctcaatct tatatgctgg ttcaatagaa cagcttgtcc 699421 tttaccgaca tcactgccat ggggtggtaa cacttcccat tgattgttga agtcaggatg 699481 cgtgtaacca gtaacttgtt gaccagcgga tgagatacga ccatcttcat accgttgtgg 699541 gtaacgtgcc aagtgagaat gtaagaatgc gtcagtatct tgatgtttga tagtgataat 699601 atcaaaataa ttgacggttt tagagtcaac acttaaggga gagtccttaa gtgtttcttg 699661 aaattcagca gacataaatg cgtcgccagg acctgaagta ttcaaaacgg tgaaatgaac 699721 ccagaaccaa aacaagtaaa tcacaaatgg aatcaaaact aaaccattca gccttttact 699781 aaaatgtctc atgaactgcc tcaaggacaa acccgccttg atgtccagta attgccataa 699841 gttgaccaca gcagcaaaac caatagcgga atatgtcata acaccaacat attttgtgga 699901 aatcacgaag gataaagaca aaccagtagc gtgtaaccaa atataccaac tccatgtaaa 699961 aggttgacgc aattggcact tgtagaaacg aacgtaacaa tacatagtag cagcaataga 700021 aataatcaag atggcatcca gtaaaatcag cctagtttct gtaacatgcg cagtatcgat 700081 tgcaaccaag agagatgcaa acgcacatgt aatagccctg aaattcagtt ccttcaaagt 700141 gttgaacata attggtacag tcaatgtgcc caatatcgcg ttgaaagaac ggtacgcgat 700201 atatggagct ggatgagttt cataagaata cccaatctca tcaaacttaa aggaaccatc 700261 atagccacat aaccaaccaa tgaaggcaat catcatctta gcaaaagggg gatgaacgtc 700321 aaagaaataa gacctttcta agtaatacga tgcaaatttc ccgaaatgta cctcatcaaa 700381 aacaacttct tttggatacc agatcttata aaatctagca gcaaacgcta ataaggtaac 700441 aattgttacc caaaagctat aacgtgattc cggttccggt agtggctgca agagccaatg 700501 ttcagcaact tgttcacatt taggcgcggc cttcgtgtac ttcaacgaag gatcgtctac 700561 gtccttagtg gaaggtggta acttcccatg gttacgtttt ttgggcacag acatctgtac 700621 ttctgtggac tgtcagaaaa tatcttggta aaatatgtat cgacaaactt cttagtacag 700681 ttaatataga agtaaggatt cgagtgagta gttttgataa agcgcgtttc attatgcata 700741 tttttcattt tttatttttt ttgtcaagaa atacacgaat aacatcacga aatttatcga 700801 cagaataatg gaagaaacta tttaaaaaga cggtagagac taaaaaagga aagaaaggac 700861 aagtaggaag atcagcgtac gatgaaaagc attttcaagg ttagaggatg tgtatcgcat 700921 gctgctcaat tttgccaaaa aagaaccgtg gtgagtaccg gcactagtaa caccgcaaca 700981 gccggtgcag tgaggaaaag tttcaacagt accgaaacca agcctgtatt tgcaacaaaa 701041 tcggaagctg gcaatggaag ccacatgaag gaatattcaa gcggcattaa ctctaaactc 701101 ggcgggaccc ctttggaaac ccgcagcacc gccgatgatt ctttgaacaa tagttataag 701161 caagtcaagg gagacattga ctggtatact tcatggtatg gcctaggtat gaagcccttt 701221 gaagcaaaag tgcaaaagga tctaatcgag cctctggacc ctaaggatat agaaatcaag 701281 ccagatggtt tgatatactt gcctgaaatt aaataccgta gaatactgaa caaagctttt 701341 ggcgcaggcg gttgggggct agtgccaaga tcacaaacaa tagtgacatc caagctggtc 701401 actagggagt acggtcttat ttgccatggt caattgatca gtgtggcaag aggcgaacaa 701461 gactatttca acgaagccgg cataccaact gctacagaag gttgcaaaag taatgcatta 701521 atgaggtgtt gcaaagatct cggcgtcggt tctgaattat gggaccctgt tttcataaag 701581 aaattcaaag tggatcattg tactgagaag tttgtggaac atgttaccac caagagaaag 701641 aagaaaattt ggttaagaaa ggacagacaa gttgaatatc cttataaata gtcaatatgc 701701 gaaccatata agctaatttt agtaagtata tatattccaa tacaatcaca cacacacaca 701761 cacacacaca cacacacaca tacgcatata ttgtggtagt gcgtagtgtc agtacgtctt 701821 atcatacgcc ttctatttca gggttagcgt atttttacta tcaatattac aatacggata 701881 tatatacaca cacctaatat atatattata cgttatatta ctgccagtcg aaaaaggaag 701941 atacgatgta ttattttaaa attcaatttc taataaacat taatggagat atacaaaaga 702001 agaaaataat taagttgtta tgaaatttat aaaccttgtt gagctcttct tctgtcacgt 702061 tcttcagcaa tagacaactt gataccctta ccctttggca aagaaatgta aggcttacct 702121 tgttcaccga tgacgaagac attgttcaat ctagtgacga aagtgttgtc caaggagtcc 702181 ttgatgtgaa ctaaatcgaa accaccatcg tgtctttcct tgtgaacgat agtaccgata 702241 cgacccaagt tacgaccacc agtaacgtaa accaacttac cggcatcgaa cttgatgaaa 702301 tcagtaatct taccagaggc caagtcgatc ttaacagtgt cattgacctt gatgtttggg 702361 tctgggtatc tgatagttct accatcgtgg gtaacaacgt atggaacacc cttcttacct 702421 aattgaacct tcttgacctt acccaacttg taagaagctt cttcatcggt gatacggtgg 702481 acagcgaatc tacccttgac atcgtagacc aatctgaagt tttcattggt ggcatctaga 702541 gtgatgacat ccatgaaacc agctgggtag gtagtgtcgg ttctaacctt accgtccact 702601 ttaacgtgac gttgcatcaa gatagccttg acttcacggc cgttcaaagc atactttaat 702661 ctgtttctta gaaagacaat caatggcaag gattcacgca atttgtgtgg accagcagat 702721 ggtcttgggg cgtaacaacc ggacaacttg tccaataacc agtggtgtgg agctgctaat 702781 ctttttagat gcttctttct gtacggaaaa aaatgagaaa aaagggcaaa aatgaatgta 702841 taatgaagat acagacattt tatttttttc attgtgctcg ttagtaaatc attactcgta 702901 aaatatttgt acaatcccag gatgatctaa aattaaatgg acataaactg gttcattgtt 702961 gttcctattc gtttggttaa gactccactt gtttcttgtc tatcattctt ctcatccttg 703021 cgtaattata atcaaagtct atagtcaaac atacggtcct ctagccatct ttgcgtattg 703081 attctttggt ttgttttggg cagaaaaatc gctatataag aaagtatttc aacactagat 703141 taaattatag tataattttt aatatactag tattgccgac aatctctgaa atttcaatac 703201 taccacacag aacaggactt gccagggcca gtccgagcca gcctaactcc aagaccacgt 703261 actaagtgaa ttgctactcc cccttaccac gactacaaag agctacacgg cctcccggcc 703321 taggccgctg ctactttcaa ctgatgtcac cgaaaaaaat aacggaaaac gacagttcaa 703381 gaaaaaaaga acgcaggaag aaaaaggaag caaaattaca gaatgtacgg ctgtttaaaa 703441 ataaatagtg gatgcatggg tgcttccacg cgtctctggg aaaaaaaacc aggatatttt 703501 aatgtttgtt tatttgttta tttcctgctg aactgaatat tgaaaacatc gaaaaaatgc 703561 agtacccagc tctccattag gactttttac gtaatgacga aaatggacaa gctgcgcagg 703621 aaaggactac gaaaagtatg ctgccataat gacaagataa ggcgcaacac acgtaatcat 703681 gactaatggt tgcacagacg gtaggccagg agaaggatta gatctcgtgc cgaacgacag 703741 caagctagct agactatgtt atctgagtgt aaacgaaagc gcagcagtct ctgcaagagc 703801 acgtgcgacg tgtctggtgt gcaaaaaccc tctagagaaa cattgctaag gtttaccgat 703861 gcaggaaatc tttagttcta aaagatgaaa gtcggaaaag ccaaaaagaa accggaaatc 703921 ttctctgcgc attgttctgt ggccacggcc ttcctggacc cgtccttctt ttacccgaac 703981 tttgtcgccc aaaaggcatc tcattataat gacaaaactg gatctgcaaa tatttggaca 704041 tatatctcca gaacgggctc acttctcctc ttcacccagg tggtatatag gaagagtaag 704101 tggacgcatc agtccgcgac atttgcggac tgtatatatt gccagtcagg gcagtcgcca 704161 agtgtgtctc tttcgtgtag cgacgcacgt cagacatgga tgcaacatcg aggatggagc 704221 agcctgatgt ctttgtaagc aaactctacc acctgctgca ggggaacgct tactcgaaca 704281 taatacaatg gtcgactgat ggcagcaagc tcgtcatttg gaatccggac cagttcacca 704341 aagtcatcct agagcgattt tttggtattc acacctttgc agcattcgtt aagcaattga 704401 gcaaatataa cttccagaag gcgggccgcc cggactgcgt ggagttttcc aacattcatt 704461 ttcaaaaaga taacattaat agcctctcac tggttaaagc tcatcagtct gccgccactc 704521 ccaatgtcgc cgccgtcaat aatatgaata agcagtgtac ttttcactgg gaccctttca 704581 aagtgaactc cattctaagc aaggccatcg gcaagccttc cttcgagaaa ttagtgaaaa 704641 atgttgacag gcttcagggc aatcttgatg agcttaagtc gacaaacgca gatagtctgc 704701 gtattataag ggaaattaac gccagcttac agacaatctc ctaccaccag tttcacgcct 704761 accaaaccgc taacttcctt caagaaaatt ttgaagccat caaaaaggtt gtatgcccgg 704821 actcttgtct acaacaccag caacgccaac caaagcgccc caaacgctac tcgttgctgt 704881 tactaatacc aaacgcatcc gaattgtcag aaacaccttt gatgcgcttc gccggcgtgt 704941 tcgaatttat gaactgctct ttggatacgg ccactcagtg gcacccgcag ttgcatcccg 705001 aggcatacga ccttcttttc gtcaccgtgt cgcccaacat gcaacaagaa catctcatct 705061 acttcaagag actgagaaac ctactcccaa gctttcctgt aatagccatt attaacagac 705121 ccgtctcccc tcaagatacc agcattgctc cctccaacta ctctcgctat tatttccacc 705181 attttttgca gttggggttc agtgacatcc tagttagccc cttcacccca acacaactta 705241 taacgctcct ttccaaacat cttcgaacgt gaaaacctgc ctctgagggt cattcacgac 705301 ctagcatacc actatatacg tgtacgattt tttttttctg tgaccgcact acaccaaagt 705361 ttaatgttcc attggccccg gaaccattct tgcaaacggc gttctttttc cgctttcggg 705421 tgacacttaa tttagcttct tttccctctc tgacacctct tgttatctaa tctgtagatc 705481 cgactctttt tctttttggt gtcgttcttc tatgtccgtt tttctgtcaa caaaaacgga 705541 aataataggt agaaattaag agccgtacgt gagtgagagg agatccgaaa tgagctgaca 705601 gtataactaa tataagctta caagatattc gactatttcc tgggaaaaaa ttcattcctt 705661 tgagaaatcc ttaataaaaa cagactaact actaaaattt tagaaattta agggaaagca 705721 tctccacgag ttttaagaac gatatgacct tggcacccct agacgcctcc aaagttaaga 705781 taactaccac acaacatgca tctaagccaa aaccgaacag tgagttagtg tttggcaaga 705841 gcttcacgga ccacatgtta actgcggaat ggacagctga aaaagggtgg ggtaccccag 705901 agattaaacc ttatcaaaat ctgtctttag acccttccgc ggtggttttc cattatgctt 705961 ttgagctatt cgaagggatg aaggcttaca gaacggtgga caacaaaatt acaatgtttc 706021 gtccagatat gaatatgaag cgcatgaata agtctgctca gagaatctgt ttgccaacgt 706081 tcgacccaga agagttgatt accctaattg ggaaactgat ccagcaagat aagtgcttag 706141 ttcctgaagg aaaaggttac tctttatata tcaggcctac attaatcggc actacggccg 706201 gtttaggggt ttccacgcct gatagagcct tgctatatgt catttgctgc cctgtgggtc 706261 cttattacaa aactggattt aaggcggtca gactggaagc cactgattat gccacaagag 706321 cttggccagg aggctgtggt gacaagaaac taggtgcaaa ctacgccccc tgcgtcctgc 706381 cacaattgca agctgcttca aggggttacc aacaaaattt atggctattt ggtccaaata 706441 acaacattac tgaagtcggc accatgaatg cttttttcgt gtttaaagat agtaaaacgg 706501 gcaagaagga actagttact gctccactag acggtaccat tttggaaggt gttactaggg 706561 attccatttt aaatcttgct aaagaaagac tcgaaccaag tgaatggacc attagtgaac 706621 gctacttcac tataggcgaa gttactgaga gatccaagaa cggtgaacta cttgaagcct 706681 ttggttctgg tactgctgcg attgtttctc ccattaagga aatcggctgg aaaggcgaac 706741 aaattaatat tccgttgttg cccggcgaac aaaccggtcc attggccaaa gaagttgcac 706801 aatggattaa tggaatccaa tatggcgaga ctgagcatgg caattggtca agggttgtta 706861 ctgatttgaa ctgaagtatc gctattgcta cgtaaagtaa ttaaaagtta aaaagaataa 706921 aactagagcg ttttttctac tgagttaagg ggtcatgtca gaatataaca taccctttga 706981 cattgtatat atgaattcct ggattttgca gtgatctgat aaaaaatgta tgtcgaaacc 707041 tgcaattatc ctttcgtttt ttttcttgtc atctagtgct ggcctatcgg tatcaaggac 707101 atcttttgcg cggatagaaa agggcccata cataccttag aagcaactca agacaattca 707161 tgtacttttt aaaccaacta atatttcaag acgtttccgt aatgtcggtg gataaaagag 707221 aagatatgag cagatctttc caaaaatgtt taaacttgag ataccctatc atccaggccc 707281 ctatggcggg ggtcacgact attgaaatgg ccgctaaggc ttgtattgcg ggcgccatag 707341 cttcactacc cctatcccac ttagacttca gaaaggtcaa tgatattgaa aagcttaaac 707401 tgatggtttc acaattcaga gatcaagtag ccgatgaatc tttagagggc aatctcaacc 707461 taaacttttt ttgccatgat atcgttgata aaccgaccga tcttcaaaca gctaactggg 707521 cgaagctata cagaaagtct atgaatgtgc cgattgatat gaatgagatt aaattcgata 707581 atggtaatgt atcttttaag gcatttgaaa aagaaaatgc tcttcaagat tttttccagt 707641 acctatcaga tggctttagg cctaaaatca ttagtttcca ttttggccat ccgtcgaaat 707701 ctacaataga atatttacaa aaaattggaa ttctaatttt tgtgactgcc acctctgtaa 707761 gagaagttcg attgttagca cgtctcggca ttaatggcat agtgtgtcaa ggctatgaag 707821 cgggaggaca tagaggaaat ttcttagtaa atgaccccaa agatgatgaa aacttatcaa 707881 ctgtacaatt ggtgaaaaga acagttgatg aacttgctga aatgaaaaat aaaggtctta 707941 tacatgctac tccctttgtc attgcagcag gtggtataat ggattccaaa gatatatcat 708001 acatgttatc acagcaagca gacgctgttc aagtggggac tgcttttctt ggttgcagtg 708061 aatccaatgc atcaaaaaac ttttcaagcc ccttcactcg agaaacaaca actaaaatgg 708121 ttaatataat atcaggaaag cctgcaagga ccatctctac tccttttatc gaaaaagtca 708181 ttgctaattt tcaaggtgag gagcttcctc catatggcta catgtatagt gctttcaagc 708241 aagtaagaaa aaagtatcca gaattggcta actttatttt agctggacaa ggatttcaga 708301 atgtccaatc aggaatcaca acagacaaga aaattgaaac tatgggcgca agattgaaaa 708361 ttgacggaaa ataatataaa tacatataaa agacctgata cttattgaca caaattttct 708421 ggatgacctt tttctatatg atatatatac gtcgctattg gatcgtaggt tacttggcca 708481 ttatttgagc gtaaccgttc acaggatgtg ggctttaagg aatacaaaat ccaaatatgg 708541 aaaaaatttg atatcaattt agggctttaa tatctaaagg tatttatttt tttcacagtt 708601 ttttttctgt taagctgtct gcaataagga atgctcctga catgaaattc gaaaaggacc 708661 ggaaatagtt ggagcacaag actgcaaact aaaaaacaaa tttctttgga atttccttac 708721 gcttatagta tatatcttat aaatattaaa attaagagaa ttcaattatt ttacatcatt 708781 tatacaactg tacagggccg cacatgatca ctataacaat agagcggcgg caccagcaat 708841 agcagcggca ccgaaaacac cgttattgaa cttgttagca ccgttagtgg taacgtcaat 708901 aacacgagat gctgacgatg tgacagaagt agctgtagat tgagctttgg aggagactgg 708961 cttagtcaca gttgaacaga cgttatttga acaactagtt atggtagttt caacagtgga 709021 agcttgagtc tttgtgacgg tgctgtcagt accattttgg accactggag tgactgagat 709081 agaagatgta gaagaaactg gagctgtggt attggcaaaa ctagcagagc ttgcaacaga 709141 gcttgcaaca gagcttgcaa cagaactttc agcagaactt gcaatggtgc ttgcagcaga 709201 gctagattca gatgaaacag tagcttgggt ggaagcagcg tttgagctgg tctctgctga 709261 actttcagag gagctagaag actcagtggc ggcactagaa gcttctgaag tggaggtgga 709321 agaagcctct gtggtagaag ctggtactgc agtagcaata ccttcattcg caagtgcttc 709381 ggaaatagca cccatcaatc tagtagagta ccatggcaca ccggtgatca ttctggtcac 709441 ttcatcacct gaaataccag tcaacatggt ggtgaaatcg ccaccggcaa aaacagcctt 709501 ggcaatttca ggtgggtatg tttcagtctt atgcaaagcc tggaaagcgt aatattcaga 709561 taaatgggcg ccaatatcag aaacgtaaac agccaattca atcaaattga ccctttcatc 709621 ataaggggat agagtggtgg tcacggatgc ggcggttgca cttgccacta atgctgcggc 709681 gacagctaat atactaattc tagacattac ttggggtata tatttagtat gctacacttt 709741 tatctgaaaa agaagaaata gtaccgtgtc gacataaaaa tagtatcatt tagtcgtgct 709801 attttatacg cagtattttc aatcatttct attcaatgag tacccaggga cccttttgca 709861 tttctagcat tctctgttcc tgaacgatgt tttgttagag gcctcgtata gatcttggca 709921 ttttcaaagg cacgcgttgt attgttttat tgcctatcaa aggaacgcgc aggaaacatg 709981 aaacttttca gaggagcgtc tacggaggat acattcatca atttttcctc ataaattaaa 710041 cgatgtgtac aaaaaggacg aattgacccc gtcgttcggc gaaaccttat gtattttcct 710101 ggccatatgt gctaaacgac agataaaata ggaaattctc cccattttcg actaataaga 710161 taagcgggag atagcatcat atgaactttt gcactcaaac gaagaaagca cgtgaggatt 710221 gaagaaaacg gatcgccgaa tccagcgtga attgagctca acaattttta actatatcaa 710281 tctctttcac tttaaacact accacttaaa tctttttaaa acgctttgcc caatgaccct 710341 ttttttatta aggttgctga gctatttttt ctatactatt gtcaaactcc aaagatattt 710401 tgagctttat tttcttgcaa acaaaatacc ctactgctta ataaatgcaa tgtatacata 710461 gttttcaagg tacattatat tttaaagtta cctcaggcct gtttgccctt gcattctaca 710521 gtccctttgt aagggtgtga gacaaaaggc ctcgttagct acgactgttg aaatcgtttg 710581 aattcggctt acaatctaac tttgactgcg caattgttca tgaatttata gtgtgcttgc 710641 gaggggcaac ttcatacgaa ggcttgtagg acccctaagt gcatccataa acatgctcaa 710701 agattgtctt agaaaccaca aggagaacgc acagtatgaa ttaaataagt tgcgctctgc 710761 tagaatattt tgacgattac aaagtcagag atcgaaacat ttccgctgtg caactaagta 710821 attttcccaa tctttggaga aaatcaataa tcacaagatt agtacttatc ctcttgtagg 710881 cttctctctt tcgctataaa tagagcagaa aaatatgata cagaaggtcg aaagtttgct 710941 tcgctgactg aagctttctg tcaagagttg acaaaaacat acaagattca gtattgataa 711001 taaatggcct gcacttaaga ctcaaccatc ccaataagtt acctagttgt gttacctaag 711061 ctaggaaaat acacattgaa agatgtttta caaagtattg taaaggtaca atgcattcta 711121 ggccgaatgt tcatttcgga ttgtaatatg tagtcaacga taacgaacct catggttatg 711181 gttatttctg ttccaaattt gcaaaataga tcttcattgt cgttgtcgga acgggtggtt 711241 tataatttta gtaaccatag taactgaata aagtgaccaa acagtatact tcatagctcc 711301 aggctaggaa acaagatact actgcgaaac tagcggaaga agttacgtta aagatctatt 711361 aattcaatgt taattcaaat ttaatatacg tagggatgcg agttattaca ttggaaatat 711421 agcaaatcac tgaaatacca tcattttgaa tacattcgtc atcgccgcat cagttatacg 711481 tttctgctat accgtataag aatacttgct tctattctta gttatactga attttagaca 711541 ttaataaact actaacggtt gctactacac tacactattc ttctaccaat gtcgatgaga 711601 gcgaactctt cagaaagcag tttacttgaa taaatttttt caaaggccct catttctaat 711661 gccttgtgac ctagaattta gcagcgtcaa ctttatggag cgttatttct caattccatc 711721 tttgtgccgc gtagttctat cttacataac tttattttaa gaagagcttt agttcatgtt 711781 cttggaagaa ttcctttttt gacacgattt ttaacctaaa ggctaaattt tatttaaact 711841 aacagtgaac aaagtattta aagcttcata tgtgagttgt cgaacacgtc aataaacgga 711901 ggtaataaaa tgaaggatga gggaaaaaaa aaaccataat tttaggctga agcccatatt 711961 gtgatatttt taatgttttc ttagaaaaat taaaaaactt ctcaattaaa tgtaaaattt 712021 tacttgttgg cgatacctta gaggattcaa atttaactag tgttaatata cgaactggta 712081 acactaatgt ttagatacct gtatatcata caaaccattc aaagtgtata ggagtatgtt 712141 cacaaaccgt agtattatgt gctacatgaa tcaagtatag atttaaaatt tctttcaagt 712201 caatttaaat tattttacaa ttgtttatat gcttgtgaag attatattgt atcactatag 712261 cagtaataaa gcgacaacag caacgatagc ggtaccaaaa atgttatctt tatcgaaatt 712321 ataggcaccg ttggtattga tactgacagt ataagaagca gatgaatgag caatggaagt 712381 agccgaggag gcttttggaa ttggtgagat gactttgctg gtagcggtcg cgattggtgc 712441 agttaacatg gtacaggttc cacctgagca gttggtcaca gtagtttgag tgatagacaa 712501 tccggttctg gtaaacatgc taatccctgc atcgacagta gtcagggtgg tacaggcacc 712561 cgcagagcaa ctgactttaa tcgctttggg gatggtcgac tctgcattgt tcgatgtagt 712621 ggctttggag ttgaaactac taaccggaga catcagcgtg gtgcaaatac cacccgaaca 712681 actagtaata gtagtttcca tagttagcaa ctcggtttta gtagaggcga catcttcttc 712741 attatcttcg caactaatgg tagcggtggt agttgcttcg ctggtgattg tagtaactgg 712801 aacagtcagg gtcgagcaaa caccaccaga gcatgttgtt atagttgttt cgaccgtgga 712861 agtttctgta gttgttaatg tgttcgcctt agcattaata gtagtaaccg gagacatcag 712921 cgtggtacaa ataccacccg aacaactagt tatagtagtt tccaaagtta gcaactcggt 712981 ttcagtagaa gtgatatctt cttcattatc ttcgcaacta atggtagcgg tggtagtggc 713041 ttcgctggtg attgtagtaa ctggaacagt cagggtcgag caaacaccac cagggcatgt 713101 tgttatagtt gtttcgaccg tggaagtttc tgtagttgtt aatgtgttcg ccttagcatt 713161 aatagtagta accggagaca tcagcgtggt acaaatacca cccgaacaac tagttatagt 713221 agtttcaacg gtagaaactt gagttttcgt caaaacacta tcttcattag tacaactact 713281 cttacagctc gtgatgacaa tttcatctgt tgataggttt gtaaatgttg aggttgcatt 713341 acgaacattt tctatcgtgc tgaacagacc gctactgatg gtgttggaac ttctggcatc 713401 actgcaatta cttcttgagg atactaagag aggggaactt gatgcaaaag atgcgactga 713461 cgatgtaggt tccatagaaa atgaagagac gatcgattgg gaaacagtga aagtacttaa 713521 agtgaaactt gacatatttg atgacgaaag atataaggaa gaagtccgct cagcaatgaa 713581 gctagtggat gtagacgtaa ttgcagtaga cgactctgga gaggaactga tttcactgaa 713641 gggaatatta ggagaaactg aatcggtaga gctagtgacc acagttgaag aaacagcaag 713701 tggagtggaa ggcgtagcaa aaaaggtagt agattgggta gaggagttac cagagacatc 713761 agatttagca gaaacagtgg atctggtaaa gaaatcagca gccttgctcg aggaaacaac 713821 ggctgaagtg aaagtggatg tggcagatag actttcagta gaagaaatgg attcatcaga 713881 agaaggtcca accaaagaag tgggttcaac tgatgaactg atcccgcttg aagtaagtac 713941 ttcaatggaa gaaggaatct cagaagagga agtaattaca ctagaaacta ttagttcact 714001 ggaaatggtg atttgattag aggagataga ttctgcggaa gtggttgctt tactgaaaga 714061 gagaggttca gcagaagagg tgatttcact gaaagtagac ccgaaggaag aaacaggttc 714121 tgtcgtggtc acttgactag acctgatagg ttcaacagaa gaggtgactt cacttacagt 714181 agtaggttca gcggatgaag tgacttgact agacctgata ggttcaacag aagaggtgaa 714241 ttcactgaca gtagtaggtt cagcggatga agtgacttga ctagacctgg taggttcaac 714301 agaagaggtg aattcactga cagtagtagg ttcagcggat gaagtgactt gactagacct 714361 ggtaggttca acagaagagg tgaattcact gacagtagta ggttcagcgg atgaagtgac 714421 ttgactagac ctggtaggtt caacagaaga ggtgaattca ctgacagtag taggttcagc 714481 ggatgaagtg acttgactag acctggtagg ttcaacagaa gaggtgaatt cactgacagt 714541 agtaggttca gcggatgaag tgacttgact agacctggta ggttcaacag aagaggtgac 714601 ttcactgaca gtagtaggct cagcggatga agtgacttgg ctgggactac ttgaactgat 714661 atatgtatcg ctcgtagtag tagtagttgc agaagtagtg aatgcgttag ttgttgagac 714721 actagaggtt gtatggtcag tagaagccgt agatgtggca ggtgtagtaa gactggcaaa 714781 agtggtagag gttgtagcag tggtagaaat gacagaggat gcagaggcac tagaagtact 714841 gaaagtgctt gaagttgtag aggtcgtggg agcggtagaa atggtagaag tggtagaggt 714901 tgtagaagtt gtagaagttg taggagcggt agaggttgta gaagttgtag gagtggtaga 714961 agttgtagga gtagtcgatg tgcttgaagt agtaggagta gtcgatttgg tggaagtttg 715021 agaagtggtg gaggttgtag aagttgtagg agtggtagaa gttgtaggag tggtagaagt 715081 tgtagaagtt gtaggagtgg tagaagtagt agaggttgta ggagtagtcg atgtggtaga 715141 agttgtagga gtggtagaag tagtagaggt tgtaggagta gtcgatgtgg tagaagttgt 715201 aggagtggta gaagtagtag aggttgtagg agtagtcgat gtggtagaag ttgtaggagt 715261 ggtagaagta gtagaggttg taggagtagt cgatgtggta gaagtagtag aagtgatagt 715321 ggtggtagga gtagtcgaag tactagattt tgtagtcgtt gtagaagtag aggttgggat 715381 agccgtgtaa ataccatcct ttgaaagcgc tgaagagata gccggcttta atctggtaga 715441 gtaccacgga acaccagtga tcattctagt tacttcatca cccgaaatac cggtcaatcg 715501 agtagtgaaa tcaccgtagt caaaaacggc tgctgcgatt tccgaaggat atgtttcagt 715561 cttatggtga ttccggaaag agtagtactg aaatatgtgg gctctgatgt cagaaacata 715621 aacagccaat tcaataaggt tgactctttc atcgtaagga gataaagtag tggtcgctgt 715681 aatagcagcc gcactagtag ctaaggctac aattcctgct acgatgctta tattaaccat 715741 tgctttcttc ggagtttttc ggatatcgca gattcgacag gaactggtac ttatttcagt 715801 ttgagcatac tctcaataca gccatttaca caggccattt ataggctttc gaaccaaaca 715861 gctgttgtat aaacgaatat attggagcaa aatcactatc tttgccaatg cttcttgttt 715921 tacagttcct gaacgatgga gatcttaaac agatctcgta taatttttga catctttaaa 715981 ggcacgcgat gtactgtctt tttcaccgcc aaagaaatgc gcagcatgta aaaacttctc 716041 cggagaaaac gcctacggat gggcagatcg atcgaatttc cccgtgccta aattgttctg 716101 ctcttattat ctgtgattaa gtgacagaac tgcaaaaaaa gttaatttga tgtcgtcgtt 716161 caatagacat tcacataact ttactctacg tgctatacgc gctaccaaac agaaagatca 716221 ctttttccca gtcagtagac actgggtcac ttggggttta gcacactcga aaaggagtaa 716281 atatgctgca aacgagaatg tgcaagcacc attcagagga tcttagctcg tagagagaga 716341 gaagctgttt gtgctatcca attttgatcc tagcgctccg aaaaaggtcc gtattaggaa 716401 actagatctt gttaattgaa atatctcctc atttttttgc agcccgccac tcaatgcgct 716461 ttgtaacctg tcatagcttg cacagagaag tatcaaagtc tacatgtgac aaaaagaaaa 716521 cccaaatact tcttggctat gaatgttatc gtttgatgat aacatccatt cctccaattg 716581 gaaaataatt actcacgaag gttctatgca tccaaagcgg aaccgttgct ttcatttaat 716641 agaatccaca gaacttttag tgtgatttat acgaattcca agggagacct cgacgtgtga 716701 cttgaattaa gaaaaagcct tgccaatcat aatagttcat atatgataaa cggtcttgat 716761 tcgggttctt atagcaacag taacgaaaaa tctctaccct cataacttag tattgttgtg 716821 ttagcggtca tgaaatcttt tgtatttcct ttaacatatc agttatattt tcttcacgct 716881 acgtcagccc cattattgtg ccaacagttt acatcctttg cattcagagg tggttcatta 716941 gtcgcctaca gctgcccgtt tggaatgacg gcccgtagag gacacgttaa tagaagacat 717001 tccccgcgat tcgacgagta cggcgcactc tcaatgattt gtaaaggttt catatcaaac 717061 tatcaaaata tgcggggctc tgcgtaaaca gaagcaatca gactacataa ggtcctcagt 717121 gtaatcttac cgtaggccga tatgtcttcc attgtgagaa tttctcaaca ttctgtggtt 717181 aatcaaccaa atcatgcgat actaatgatc ttgacgggca tacataatag aagctaaaaa 717241 aaaaaaacta gcctgaagct tattctgggg cccatatgct cgaaatgcca aattttcaaa 717301 aatctagccc tacatgcaca acaaatgatt gtgcctgcct cctggcagga aaagggttga 717361 tatgaagatg tccggcggcc tcttaaactt aagattgaaa gacatgctaa ccttgttccg 717421 ttttaaggat aaagaggagc ctcaataaat gtgtagttat cccttgctaa taaaatagtc 717481 ttattatctc gccactataa aagtcgaagt aaacagacag agacatgttc gatactccac 717541 ttgcacttcg aaaaagtaat taggaatcct atatatgcga tgctatcgtt aatcttttac 717601 cttcgtttcc catcttatat aaggggatga cgaaaatacc tttcggctta caaatccatc 717661 tgtaacagct gaaaaaaaaa accagatctg ttgatcagtt gtaatcgtgt aaacgagtac 717721 aaaaggccag agacagcttc tactccaagc ttaagatacg tatacacaaa agatttttac 717781 ttgaaggagt agagccgaag cgtgtgagta tgacagcgct gcgtaaaaca tcagagacgt 717841 atgtaatctt cttgtctaat ccattattgt caataactca agctatattt acatctttag 717901 cgaagtcaga aacttattgt catcctttca agcctcgccg ttgacatccg ctgtcagcat 717961 caccctcacc taaagtgtta ttacacgaag aactgattaa atacgccgag tttgggatga 718021 cctgttctta cccgttcatt cctttttatg gcacactacg gttagtatac ggcgttggcc 718081 gtgtgatagg gaaaaatagg gtaggtaata gagaacaatt gatgagtttt atgtaattgt 718141 attcgcgcaa aaataaaaga atatcaacaa aaaattttga ttcgtttact tcataaaaaa 718201 aaatcctaaa atttatgaaa atgattaaaa aaagacatcc acttccccat agtgctaaat 718261 tggtatggac gttaaatagc ttttatcgtc gttggttttc agacaaatgt gtagcaccct 718321 aagtgtgaga tatcatatat ttcagagaat atagcaccaa gtatcgttat gcgttctggt 718381 ccgtacctga gagctgctca taagaatagg caaaagcaag aaagagtgtt ctgtcaggaa 718441 ttttcaaact atttacaagc taggaaggct atacgtagta aataacagcc acgattcgac 718501 gtggataaac aaacatctac gaaatcccat tttggcatga aaaagtggag caagaaagac 718561 ttgaggtatg aaatacttgc aatctttcac atcaacacta ctttcaagat gttattgcaa 718621 acagaaagtg cgattctctt tctttcatcc gggcgttaca gatgaccata tcttcagtga 718681 ggataacgaa agataaagag tgctggctca cattaatgga aaaagaaatc tacccgctaa 718741 ttgtgatggc tcagagtttc ttcttatgat aaggatgtta gtttatatct tgacatgtgt 718801 gtttctattg tacaccgtaa tagcagatta gataaacgag aggtcattcg taaggatgaa 718861 aaaatgaaca tctgtttaac tttcaagctt tctaccatat agccgagatg agcaaataca 718921 ttaaaacatc aaaaagtggt gcttgaatgc ttattttatg acgcaaagca gatgtaatgc 718981 atcccgagta aaacagaata cttaatttga cttcagcaaa ataactaccc agaatgaaca 719041 ccgaatttga cattgataac aagacaatct aggaatactt ttacatcagc acaatatcca 719101 tggtggatcc cggcggattt ttctttctta ttgcacctta atcaggttta cagcctatga 719161 ctgactctgg agtgtccttt cccagtatct gattgtttcc gcaacatcta tgcatatcag 719221 agaagcgttc tcatcagtca cttgacaaat gctcgaggag ctatcatttg ctgataaggt 719281 gctacagcgc gctcctgccg cacgctttgt tccttttcga taagagtccc tcgcgttagt 719341 ctgagtgaag tgcggaattc agcaaacgaa taacaatcga ccttatgatc atgtggatta 719401 tcggggcaaa agatttggcc aagatgtcag agaacgttat caccaatcac tcacacaatt 719461 aagtggtagt gtaactccga agatacggct aatacttatc attatctggt tttccgaata 719521 tacagattgg atgaagtaat atatgtatat aaatggacca aggaaacatc aaattaggag 719581 atcatgaggg aaaggtttaa cataacaaca ttgaagaaaa caacaaaaca aggataatca 719641 aatagtgtaa aaaaaaaaat tcaagatgtc agcggatgct agtacaaatt cgaatgcttc 719701 cctagacgaa aaaaatttaa acatcacttc agaagctgaa atcaagaatg aagacgtaac 719761 cgcggagcca gttctaagca cggtactatc acccaacggt aaaattgtct acatcagtga 719821 caaggttgat gaggccatga agttggctga agaagccaaa gaaatcgaag tgacaccaga 719881 agaagataga aaacttcgtt ggaagatcga ctattgtatg tttcctttga tgtgtatatt 719941 gtatgctgtt caatttatgg acaagatttc cactagttca gcggcggtca tgggattaag 720001 aactgacttg aaaatgcatg gtgaccagta ttcatgggtt acttccgcct tttatttcgg 720061 ctatctattt atgaacctag gcccggtaca gttcattttc caaaggacca gtcacatgtc 720121 aaaaatgctt gcggttttta ttgtcatatg gggaatgtta ttagctttac atgcagctcc 720181 aacagttaag tatccttctt tcattgtttt gagagtactt ttaggttgcg cagaaagtgt 720241 tgtcacacct tgctttacca ttatcactgc tcaatactgg aagacagagg aacaattcac 720301 aagagtatca atttggtttg gtatgaacgg tcttggctcc atcctgatca acgcaattgc 720361 gtacggtgtt tacattcacc aggattctta tgctattaaa ggctggagaa ccttatttgt 720421 cattactggt gtgataacaa tcttcattgg tatcttgata ttcctgtgga tccctgacga 720481 tccatcaaaa gcaaggtttt tatctaaaag agagaaatta atggttgtcc aaagaattag 720541 gtctaaccaa caagggttcg gtaatcacga gatcaaaaaa taccaaatta tagaggcgtt 720601 gaaggatgtt aggacgtggt tatatttcct ctttactgtg agctctaata ttcctaatgg 720661 tggtatttca agttttatga gtattctatt gaatagtgat tttggatatt catcaaagga 720721 aaccctatta atgggtttac ctacaggtgc tgttgaattg gtaggttgtc cactttttgg 720781 tattctagca gtttatgcag ccaataagaa gataccattt tggaaatata agttgagttg 720841 ggctattttt gcagctgtct tagcattgat tgctagctgc atgttagggt ttgcaacaaa 720901 ctccaaaaaa gcaagactgg ctggtgctta cctgtggtac atctcgcccg tctcatttat 720961 ttgcgtactt tccaatatca gtgcgaattc ctcgggatat agtaaaaaat ggactgtatc 721021 ttcaataaac ttagtagcat atgctgcagc taacttggca ggaccacaaa cctttattgc 721081 taagcaggct cctaaatatc atggcgctaa ggtcgctatg gtcgtatgtt atgctgttat 721141 gatcgtgctt ctatctatac tgctcatcgt caatttaagg gaaaacaaga gacgtgataa 721201 gatagctgcc gagagagggt tccctgaaga aacagagaat ttagagtttt ctgatttgac 721261 tgattttgaa aatccaaatt tcagatacac tttatgaaat agtggtgaga tacactgaca 721321 ttattgttat cagagaagaa tatataaaac taaaatactt aatatcaaaa taaggaattt 721381 tttatcaaag tagaatttct gtaagctaca ttctcttggt gtagaagatt tctcgactga 721441 tgtaaaggac aagtcgactt gtcctgcctc atacatactt gacgatgaag agcaagatac 721501 tgagcacgtg aatcgaggaa caggtaagga tacctcgaga aatgaaaaaa aaaagttgat 721561 cagccgtact tgaaaattaa atttggcggt gagaaagaca atatcgtaat gaaaatgatt 721621 ctgacgaccc tttgatagtg gcaatgatca aaaagaaaaa aaaaagataa gacggtagtg 721681 tgaagatgac atatagcgct actctatact cgtccaactt cgaaaataat atgtggtcgt 721741 tggtacgttc agataagaga atacatctcg cgcgtacgca taattgtggt ctaaaaaacc 721801 gctgaaattt tctcaatact gaatagaatc acgctactac gacaagactc ggttactgtg 721861 cctaaaataa tcctgtgata aacgagttat gttaaacgca gtacaggggt taaagggcat 721921 tgagtttttg tgagtggaaa tgcccccgtt atagcttcca gtttaattac aaattatcaa 721981 tttaagcaaa tataactgga ggattgggga ggcgactaaa aatggctacc acgctattag 722041 acatacaaca ttgagtattt tatgtaattt tgttactgct agcacggcca tgcaattggc 722101 aactgaaagc tatctgacaa cttaaatgat tcttaaaaca atgacgacta taatcttctc 722161 taagaagttt catatccatc ttcctcatta ttcagtttct ttttcctctt gaaagtatcg 722221 taaagaacaa cgtcttcaca ttagctatta gaagaccatt gaactaccgg atatgagtaa 722281 gagtgatctt gccgtagaga taatagctgc acaaaggcca aggattagat taatgggtgc 722341 attgtacgaa aaaaaatagt ttacagtcat ttattcgcaa taaatcaatt tttttttcaa 722401 aaaatatgta agtctgataa aaaattcttc actgaagaga gatgcttaca ttctaattct 722461 tgaataaaag actctctaac gctgtgaatt ctctttagct gtaacggaaa cagagagtta 722521 ttccgtagtc actgaatttt ttttttttga cgctattatt taaaacctag gatatccgtc 722581 ccatacaaaa cggccacgag tttcaatccc agaatgtacg agttataatt ctcctagatg 722641 catgatactc gtgcattcgt ttaacaatca taccaatttc ccattttcgg gatattaaac 722701 atgaacatac ttttttactg tgagaatgtg gtttcacaat tattccatac aggtataaaa 722761 acgcacagaa cttcaaacgg gaagactatc tacccacatt gatggacaaa cgcaatgatt 722821 tctgctaatt cattacttat ttccactttg tgcgcttttg cgatcgcaac acctttgtca 722881 aaaagagatt cctgtaccct aacaggatct tctttgtctt cactctcaac cgtgaaaaaa 722941 tgtagcagca tcgttattaa agacttaact gtcccagctg gacagacttt agatttaact 723001 gggttaagca gtggtactac tgttacgttt gaaggcacaa ccacatttca gtacaaggaa 723061 tggagcggcc ctttaatttc aatctcaggg tctaaaatca gcgttgttgg tgcttcggga 723121 cataccattg atggtcaagg agcaaaatgg tgggatggct taggtgatag cggtaaagtc 723181 aaaccgaagt ttgtaaagtt ggcgttgacg ggaacatcta aggtcaccgg attgaatatt 723241 aaaaatgctc cacaccaagt cttcagcatc aataaatgtt cagatttaac catcagcgac 723301 ataacaattg atatcagaga cggtgattcg gctggtggtc ataatacgga tgggtttgat 723361 gttggtagtt ctagtaacgt cttaattcaa ggatgtactg tttataatca ggatgactgt 723421 attgctgtga attccggttc aactattaaa tttatgaaca actactgcta caatggccat 723481 ggtatttctg taggttctgt tggtggccgt tctgataata cagtcaatgg tttctgggct 723541 gaaaataacc atgttatcaa ctctgacaac gggttgagaa taaaaaccgt agaaggtgcg 723601 acaggcacag tcactaatgt caactttatc agtaataaaa ttagcggcat aaaaagttat 723661 ggtattgtta tcgaaggcga ttatttgaat agtaagacta ctggaactgc tacaggtggc 723721 gttcccattt cgaatttagt aatgaaggat atcaccggga gcgtgaactc cacagcgaag 723781 agggttaaaa ttttggtgaa aaacgctact aactggcaat ggtctggggt gtcaattacc 723841 ggtggttctt cctattctgg atgttctgga atcccatctg gatctggtgc aagctgttaa 723901 tcctctttta aagtactcat atgactatac ataccttctt ttcttttctt tactattcaa 723961 tacataacag aacaaagatg caggaaaata ttggtatttg ttcggcaatt tatgctgggt 724021 ttttttgtaa attcaggtct aattattact gttgatttgt atcaagttgg tatctttttt 724081 gccatttaat aatagagata cgctatgctc atccggatag caacaatgag agcctaaaag 724141 tcctaattga gaagaaaatc tctgttcaag actatagttt atgtttcatt ctggaccctt 724201 gggatcgtct gaaacaggaa ggtcaataat tggtaaaaaa aatggtaaat gcgactaagt 724261 actacaattg aaacgaatga gcgcacttca tctgcctaca aaacgctgcg gctgaaaaag 724321 ttacataaaa aaccgtcctc aatagcgtta atccagcgta catgagaaag taatgacaaa 724381 gtcttcggta atatcagtgc atctaccaat atgacacaat tgtgaaactt cgctgactca 724441 aataatagcc ctgttttttt gaccattgtt acccatcgag ccagtgagaa aaaagccaaa 724501 atatctttaa ggccttctcc attttatgtt tatcgatatt gtgttgtctg caatattgaa 724561 attttaaagg ctatttactt tgcctcttgt tataaactaa gtctgccgaa ttatgcaata 724621 tatagcaaaa gctgaaaata gatgtaatta cataattcgc agttgtatat gagtatcctt 724681 aactcgtaca ttccagttca tctgtgacaa ggcactgttt tccctaataa ttattaggga 724741 aacgtccttc aaaaatcaaa ataattttag agagtctcat caaccttcgc catagttcgt 724801 gatgaaaact ttacggtacg tcagacttta gatattgatt tttttattat ttctcccatc 724861 gtgagtacaa ttaccctagt tcgaactata tctttcatta ctggcggaaa aaaaattcaa 724921 cgaatgttct tggctcaata tagcttagta tttatgttta aagaatttgt aatatgcgtt 724981 actagtaatt cctttgaatt tttgaatgct ttaactgtga gttggcgtac atgcagaaac 725041 ggccgtttaa aattttaccg attgcagtga cagaaaagct agttgaatat ttgtttacat 725101 aagcgattca gatagacccc taataatatc aagctagata tgcctgttgg aaacttctca 725161 aaacctgcgc tagacgtccc acgcaatcaa cttacagata tgtcagtgct agggaaaagc 725221 catagaatgt tgaaaaaagc gaaaagggtt tactaactta ggcaggttga aaagcttctc 725281 gaaaaataat accttttggt aaaacaacgt aaagaagtac tgccataacg tagaattctg 725341 cagttatgaa catactacag gcgaaattgc taaaattaat gaggatagtc aaaattgggt 725401 tatgaatcaa agttttttat agattttcag caccggtgtg gctagtagtc gtccatacat 725461 gactcaaaga aaaaaaaaat aagtgacata acgcgaagtg aggcattatt gggctgctaa 725521 agaattttac gttggaaaag aggcaagatt gtctcatttt ccttcaaaat gaaggtactg 725581 ctgccccgga gtaatagtaa tttattctca acagaaatag aatatttaat taatcagagt 725641 ctaacattaa ggtcatgtgt tgatagcagg tgacgcgtct gtaaaactaa taaagtatat 725701 aaagcacatc catgagatct taagacgaga gatttcccct actcaaagta caagcaggac 725761 agattcaaaa cgcaatccat acgatgaaca cagattcaca caaccttagt gagccataca 725821 atataggtgg ccaaaaatac attaatatga aaaaaaagga agatcttggc gtatgccagc 725881 ctggcttaac gcaaaaggca ttcacagtcg aagacaagtt cgattacaaa gcaattattg 725941 aaaaaatgga agtatacgga ctttgcgtgg tcaagaattt tatagagacc tccagatgtg 726001 atgaaatatt gaaagaaatc gaaccgcatt tttatagata cgaatcatgg caaggctcac 726061 cgtttcctaa ggaaactact gtggcaacga gatcggtttt acactcatct acagtcttaa 726121 aggatgtggt atgcgaccgt atgttttgtg atatctcaaa acattttttg aatgaagaaa 726181 actactttgc ggcgggaaag gtgattaata aatgcactag tgatattcaa ctgaactccg 726241 gtatagtcta caaggttggc gctggtgcaa gtgaccaggg ctaccaccga gaagatattg 726301 ttcatcatac gacccatcaa gcatgtgaac gtttccagta tggaaccgaa accatggtag 726361 ggttaggtgt agcttttaca gatatgaata aagaaaatgg ctctacgcga atgatagtcg 726421 gttcacattt gtggggtccg cacgattcct gtgggaactt tgacaagagg atggaatttc 726481 acgttaatgt tgcaaaggga gacgcagttc tattcttagg gagcctctac catgcagcca 726541 gtgcaaatcg tacgtcacaa gacagagttg ctggatattt ttttatgaca aagagctact 726601 tgaaaccaga ggaaaatctt cacttaggga ctgatttgcg agtgtttaag ggtttaccat 726661 tggaagcctt gcaactgttg gggctcggaa ttagtgagcc attttgtggt cacatagatt 726721 ataagagtcc aggacatctt atcagttcta gtttgtttga aaatgatatc gaaaaggggt 726781 actatggaga gacaataagg gtgaattatg ggtccacgca ataatcattg taacgggaaa 726841 acatatcacc acaagttcgc tgtaaatgtg cagactgggt ggcatgcttc aaaagcctat 726901 tctagtactt ccctgctgtt ttcgcacgga accggtaaga aaacttcgta ccgaaatcga 726961 acaactttca ttacttgcac ttgtacaaat ttaagggagc gggattttaa aacatataaa 727021 aggatagtgg cacaactagg aataaggtgt attacccaat atgattctca ccttcggttg 727081 gggactggtt aattaattga atagcttcat aacccaccgc cgcaaaatgt gctcttcgaa 727141 atgtctgagg cttttggacc tgcacctgaa ccacctaccg agttaggacg tcttagggtc 727201 ctatctaaaa cagctggtat aagagtttct ccactaatcc tgggaggtat gtctattggt 727261 gacgcctggt ctggattcat gggatcaatg gacaaagaac aagcttttga gctacttgat 727321 gctttttacc aagcaggcgg aaatttcatt gatactgcaa ataattatta gtatgagcag 727381 tcagagactt ggatcggtga atggatggca tcaagaaaac tgcgtgacca gattgtaatt 727441 gccactaaat ttaccacgga ttataagggg tatgatgtag gcaaggggaa gagtgccaat 727501 ttctgtggga atcacaagcg cagtttgcat gtaagtgtga gagattccct tcgtaagttg 727561 caaactgatt ggattgatat tctttacgtt cactggtggg attatatgag ctccattgag 727621 gaagttatgg atagtttgca cattcttgtg cagcagggca aagtactcta tctaggtgtg 727681 tctgatactc ctgcctgggt tgtttctgca gcaaattact acgccacatc tcatggtaaa 727741 actcccttta gtatctatca aggtaaatgg aatgtattga acagggactt tgaacgtgat 727801 atcattccaa tggctaggca ttttggtatg gctcttgctc catgggatgt tatgggaggc 727861 gggagatttc agagtaaaaa ggcagtggaa gagcggaaga agaaaggaga aggcttgcgt 727921 accttttttg gtacttcgga acagacggat atggaggtta aaatcagcga agcattgtta 727981 aaagttgcgg aagaacatgg cactgagtct gtcactgcta ttgccatagc ttatgttcgg 728041 tctaaagcga aacatgtttt cccattagtg ggaggaagaa agatcgaaca tctcaaacag 728101 aacattgagg ctttgagcat taaattaaca ccagaacaaa taaagtactt agaaagtatt 728161 gttccttttg atgtcggatt tcccactaat tttattggag atgacccagc tgttaccaag 728221 aaaccttcat ttctcaccga aatgtctgcc aagattagct tcgaagatta gtcaaatcaa 728281 tagttttagt atgttcataa tgtgaaaaat gtttatatat acgcttacac acacagtttg 728341 atgattcaaa tacttagaga aaactttgcc gctcatgcat ttgcaggcat cttttattgt 728401 gttgattttg cgaggaaata aagtgttaag ataaagggag ttcatttaaa gcttgtatac 728461 atgctctgat acataaatat gtatgtctat atatcgagta ggaaacaaca gctaatgtga 728521 aatcataaac aagtcgtaga ggaaggctgg gctgaacgag tgacgaagca cgtttaagct 728581 ggaagagcca atctcttgaa agtaccttcc tgtctgcatt tttcttgatg aatagccatc 728641 aatctttgag cttccaaagg atcagaaacc tcttctggtt ctggccagga caagtattca 728701 ttagtgtagt tcgagacata gtctggtggc agaatggcta atctcttacc gtaaccggta 728761 accttcttcc agtcacggtg aacattgtac aaagatgaag agaagtaagc gtaacatctt 728821 tggtattgct tgtatgatag atcgttgttc aattgaggct tgaagtcgat gtattctttc 728881 caagccttca cagggtcggc tagaacgtag tcggttgcct tcttgatggc tttcaagaac 728941 tttctgacct tttcagggtt tttcttcaaa aattcatcgt tgcagatgta aagaacggta 729001 cagaaacaac agcaacccaa gcaagccaac ttgtcaattc tcaacatttt agcatcagaa 729061 gctggtctgc cttgcttggc caagtactct tccaattcga cttgttgcat acattcgata 729121 ccaataccag catcaatctt atcttcgatg atgtacttgg cgacattcat accacatctg 729181 acagcagtgt agtcttctgg cttcataccg tagtgcttgg tcaattcatc gatttggatc 729241 ttaccgaatt caccaacgta accgatcttc ttacccttta gggactggaa gtcttcagtg 729301 ataccactgc cctttaagta caagacaccg gtgaatggtt cgtccaacaa agaggcaaca 729361 gaggtcactg ggaaaccacg ggccttggca gccaaggtgt ggatcatggc tttcaaaccc 729421 atgtcgacct taccagatcc aattaactca gtgacatccg aaggattggt tggttctagg 729481 atggcaatgt ctagaccttg ctccttgaag taacctttgg tttgagccaa gaaaattgga 729541 atatggtatg gggttggttg ccagttcaac aaaaatgtga tcttgtctgt agacatagct 729601 tggaagtatg tgtattgttg ttgtggtatt tttatataat tgaaaaggta aaagaacgaa 729661 agaatggaca agaatattgt tcatgaagat gataatacga ggtttttata tgttttgttt 729721 gctgtcgtca caagagattg atgttgctta ttttgctata acagcaccat tttacataac 729781 ctggataagt aatatttcaa gccttctgct agttgaataa ttcgtatatt tcatagttca 729841 taagccatcc aattcgaatt gagctcattg catcatagcc aaaaatcgat aaatgcatta 729901 acgctgttac ctccaggtga ttgctgtctt tatgcattaa cgcgccaatc ttattccctt 729961 aaaacattac gccggcaaaa cgcttaatcg catatcccag ttggcccgaa agagaatgca 730021 catatacaaa tatatatgta aagggaaata ccttgtgact acacctatgc ctaagtttca 730081 gtatctgaac taggataatt tcgattataa ctctaacatt ttttacgttt tctccatatt 730141 tcgaattgtt ccttcttcaa tcaaaataat aaaaaaaaaa aatcacaaaa atgactatag 730201 tattttgagc ccaacatgac tgcgaaattg ctattaacaa tgattagtca gtagtattga 730261 ataacttaga atttaaaact accttataca agatgggcat ataaaggaca tgccaaatgg 730321 acatattaaa tacgctcgat gtaccagaac atccaggaac ttaccataga aaaatatgta 730381 acgacttata aactttaaat aaattagaga ttcaatgaat ctctaatttt ttccgcccgc 730441 ctattgaact tttactttgt cattaatcta ttctgaaata ggtacagagc gacgccagtg 730501 taaacatatg tgtgatggac atcagcattc aatgtatatc ttatcacacc agtttatcca 730561 aagatagatg cagttttgaa attggttact tagaatattt ctactacatt tcgataacaa 730621 atataactat tttgaattta aaagttgagt atccaaaaat tttagaaata catacaatta 730681 cttcccaatt acttcccaaa tattctcccc cctggtttga tatcataaaa gcaccttatg 730741 gcaacaagat tcccgggata gtaatgctat ttaaatgtat atctatttct cgaatacttg 730801 tatctttact ccactacccc tatgcaagaa gatacgcgat agtttttgtt ccttcctctt 730861 cctactctgt taattaactg aaaattattt atattgaaaa ggtacttgta gcaaattaga 730921 caaggaattc tcctggtata aagttagaga aacagaaata tgaaacggcc accccaggta 730981 tgaaatatta tcttaagaag agccatgaac acacatgaat agattcttga gacatgctta 731041 gggtaacaaa gactgtaacg ccttgttgca atactgcttt attcaaattt ttaaattgta 731101 cggaattgtg gtaaggagaa tgtgcaaata acttagcatg aaacggtgct atagttgaat 731161 cattgtatga ggtaacatca cttcaacgaa aagaagaata aaattgacct gcacatggag 731221 aaagcgtaat atataaaaaa tgtttacaat tttggcgcac tatatgggag aacagctgct 731281 ggataatatt atgcccttac ttcatttcac catatccgtt tacagttcaa atctcgccgt 731341 cgagccataa attctcaaaa ttcctttgca aatattttgc ttacctgtaa ccggcagctt 731401 acattcttcc gtcataattt ctcagacgga tgacataaac cattttttca gaatcctcga 731461 taacataatc gatcaaaaca gtaataaaca ttctcttgca caaaatggac tttggcagca 731521 aatcctgaaa tattgtggag tattgccaga ggtaaaagca acgttgaaca aattatgaca 731581 ctagacctct taggcataaa gatgacatca tctaggtact cgtaaagatc ctaaccacag 731641 attccacctt aaaagacgac aatagtaact ttgtccttga tctgggttac taaatcagcg 731701 atatgatcat taaagtgaat atccccttct taaaatgtac caaatatctt atacgtttgc 731761 agtttttctt ttcctttttc tttatttctt tggtaaggac taggtaatta tttccgtatt 731821 tggctccttt ggcgcttaaa aaatcttgta cgcaaatttc cacaagatat tgcgtgacaa 731881 ttactattac tgaagttgaa cttgtttcat gtctccgcct gtgttaactc cgttttgctt 731941 aactccgtct cgtattacag taaattcatg atgtgcctat gaatatgcag ctagcctgct 732001 gcaggcaaaa ttatttttag ctttgtgcgc tacagtggta gtaacttaaa acttaaaagc 732061 taaaatgcaa aaacagtaga gtgcggggta tgcttttctt ttgaacgtgc actgcgcaga 732121 ggcacaattt agcaaagaag tcaggcaagg tagatgatgt aaacaaacga ggacttgtac 732181 tgcgcatctt gaacctttca atatcataag tgcaatcagc taaaggtttg attttccgaa 732241 tgctctgcaa aaaagttaaa catggttata taactcaagt atgataactc cagtgttggc 732301 ctgtaatcac caactttcaa acgtataaag aaagtaagta attcattgtt tgcttcaggt 732361 ttagtcttat tactatccat agaagtaaaa ctattgatat tattgacaga aaaggaggaa 732421 aggaaactaa aggaaaaaaa tggcaagcga acagtcctca ccagaaatta atgcagataa 732481 tctaaacagt agtgcagctg acgttcatgt acagccaccc ggagagaaag aatggtcaga 732541 cgggttttat gacaaagaag tcattaatgg aaatacgcca gacgcaccga agagaggctt 732601 tttaggttac cttattatct acttactatg ctatcctgta tcctttggcg gttttttacc 732661 tggttgggat agtggtatta ctgcaggctt catcaatatg gataacttta aaatgaattt 732721 tggttcttac aagcacagta ctggtgagta ttatttgagc aacgtgcgta tgggtcttct 732781 cgtggccatg ttcagtgtag gatgttccat tggcggtgtt gcttttgcga gacttgctga 732841 tactttaggt agaaggctag caattgtaat cgtggttttg gtatatatgg ttggtgcaat 732901 tattcagatc agttcgaatc acaaatggta ccaatacttt gtcggtaaga tcatctacgg 732961 tcttggtgct ggtggctgtt cggtgttgtg tccaatgctt ttatctgaaa tagcccccac 733021 agatttgaga ggtggacttg tctcattgta ccaacttaac atgaccttcg gtattttctt 733081 gggttattgt agcgtttatg gaacaaggaa gtatagtaat actgcgcaat ggaggattcc 733141 tgtgggacta tgctttctgt gggctctaat tatcatcgtt ggcatgttat tagttccaga 733201 gtccccaaga tatctgattg aatgtgagag acatgaagag gcctgtgtct ccatcgccaa 733261 gatcgacaag gtttcaccag aggatccatg ggtactcaaa caggctgatg aaatcaacgc 733321 cggtgtcctt gcccaaagag aactagggga agcctcatgg aaagaacttt tctccgtcaa 733381 aacaaaagtc cttcaacgtt tgatcacagg tattcttgtg caaacctttt tgcaacttac 733441 tggtgaaaac tacttcttct tctacggaac taccattttc aaatcagttg ggcttactga 733501 tgggtttgag acttcgatcg tcctaggtac agtgaatttc ttctccacta ttattgctgt 733561 tatggtcgta gacaaaatag gccgtcgtaa atgtctgtta ttcggagcgg cttcaatgat 733621 ggcttgtatg gtcatatttg caagtatcgg ggtaaaatgt ctttaccctc atggccagga 733681 tggtccatcc tcgaaaggtg caggtaatgc catgattgtg ttcacatgct tctatatatt 733741 ctgctttgca acgacatggg cccctgttgc ttatattgtg gttgccgagt cattcccttc 733801 gaaggtcaaa tctaaagcaa tgtcaatttc gactgcattc aactggttat ggcaattctt 733861 gattggtttt ttcacaccat tcattactgg gtctatccac ttctattatg gttatgtgtt 733921 cgtaggttgt ttggttgcta tgtttttgta cgttttcttc tttttaccag aaacaattgg 733981 tctatctttg gaggaaaccc agttactata tgaagaaggt ataaaaccat ggaaatctgc 734041 atcttgggta ccaccctcaa ggagaggagc ttcttccagg gaaactgagg ctaagaagaa 734101 aagctggaaa gaagttttga agttcccaaa gagttttaat tgatcaatat gcgcgcttga 734161 taaacatgct aagagataaa ttcttgaaaa aaaatagggc ctactgtaaa acgaagtgac 734221 acgtaatttc aaatttaatc aacaaaaaac tacgagtttc tttgcaaact ccctttttcg 734281 gactactagt actatataaa ataacgagtt atttagtgaa agaaagcgtt tggttaaggc 734341 aacattgtac gaagttctgt ttctttaagg caaagcagag tataaaaagt aggatgctta 734401 tggagtgaaa acggagtggt gatgaagatg gggaagtcaa cataggtcca cttgagtgct 734461 tatggaagat ccttaaaaat gcatttccag gaacgtaaca ctgtaccatt cctctaaata 734521 aagtgtatac aataatatag aaatatagat tcttcccaaa tattcagttg ttactataaa 734581 gggaatattt gagctcgtta ttagcgtggc cgcacaaaca accatcatat tagaagagat 734641 aactttgttt caactcgggg gggcaaactt tctcatgctt cgttaacttg gcaaatacaa 734701 caagcatact ttttgcggtg aaaacatttt gaggcatgtt tccacacaac ataatagcga 734761 atggagtaag attttttttg tagtacagta aaaagacctc atataggtac ccgtacaaag 734821 tctctgacct ctctgggtga cctgggtcat tagtagttca aggagcatct gccactaaaa 734881 gatttgtgac ctaactgtgg tagtaaccgt taaagacacg gtattgaaac aatgggttca 734941 aaacagtcga gggttttagc atttaagtcg gcatatgtcc atttctatcc tttttccaag 735001 tctattgagt ttctttatct ttttacttat ttcctttttg aaaggtctta cgacaaagtt 735061 caaagcttga tgaattgtct attactttat ttgctaaatt gaaactctgg atgagtacca 735121 attcttcttt tcattttgcg ataattgaca ttatgatttt tcaactaatt aacatgatat 735181 tgtacataat tttttaatat caaagcgcta cgtccactga aactatagaa ccgttcatct 735241 gtcgaatcaa catctctaca attagtacga aagcttagtt tatcaatttt ttgtgaaaac 735301 tttgactaat gacgtattat tgtggtgtgc attacgacca aaaggcgggc taacaattcc 735361 aaggaaaaaa gctggtgtaa acctgactgt ttgccacggc ttttcttact actaaatcgg 735421 tagcaggcat gaaggaatcg tgaatggtgt gacctgagac aaggagaggc aggcatgaag 735481 gcaaacaaat tacgggggaa ggcacaggag atacccccac taaagattac cccacaatcc 735541 cttattttct cgagctccct gcaggagagt aagttttagg cacatatagg tgcagaaaat 735601 aaagttttcg cggacagcta ctgccgagtg gcaaaatcta tgttgaagtt ggaaagttac 735661 gcctagcttc aggaaccatc gggcttggtt ggggtgaata atgaaggaac ttcgttcaga 735721 aaactgttgt ctttaccaag cactttaatg ctttcttcct cttcaacagt taaggttcat 735781 catattctat tatctccggt ctcgtatctc ctttctccgg tcacatgaag cctctgtatc 735841 accttgctaa ccgcatttct tccatctaaa gtatgttcat tgccataagt tgcttactct 735901 ctctttaata tatagaaaaa aattcgacat ataaaaggct caatgtctta ccgttcatct 735961 ttatgaagag atatagtata agtggaaaaa agaaacatca aacaatcaac aagaaaaaat 736021 actaaaaaaa aaaattgaaa aatatgtctc aaaatagtaa ccctgcagta gttctagaga 736081 aagtcggcga tattgccatc gagcaaagac caatccctac cattaaggac ccccattatg 736141 tcaagttagc tattaaagcc actggtatct gcggctctga tattcattat tatagaagcg 736201 gtggtattgg taagtacata ttgaaggcgc caatggtttt aggtcatgaa tcaagcggac 736261 aggttgtgga agttggtgat gccgtcacaa gggtcaaagt tggtgaccgt gttgctattg 736321 aacctggtgt tcctagccgt tactctgatg agaccaaaga agggaggtat aacctttgcc 736381 cacatatggc atttgctgca actcctccaa ttgatggtac tcttgtgaag tactatttat 736441 ctccagaaga tttccttgtg aaattgccag aaggcgtcag ttatgaagag ggcgcttgtg 736501 tcgaaccctt atcagtcggt gtacactcta ataaattggc tggggtccgc tttggtacca 736561 aagttgttgt atttggtgca ggtcctgtgg ggcttttaac tggcgcagtc gcccgcgctt 736621 ttggtgccac cgacgtcatt ttcgtcgatg tattcgacaa caagctacag agagcaaaag 736681 atttcggagc cacaaacact ttcaattctt cccagttttc caccgataaa gcccaagact 736741 tggccgatgg ggtccaaaag cttttgggcg gaaatcacgc agatgtggtg tttgagtgtt 736801 caggtgctga tgtttgcatt gatgccgctg tcaaaacaac taaggttgga ggtaccatgg 736861 tgcaagtcgg tatgggtaaa aactacacta attttccaat tgctgaagtt agtggaaagg 736921 aaatgaaatt gattggatgt ttccgttatt cattcggtga ttatcgtgac gctgtgaact 736981 tggttgccac aggaaaagtc aatgtcaagc cattgataac ccacaaattt aaatttgaag 737041 atgcagccaa ggcttacgac tacaacattg cccatggtgg agaggtagtc aagactatta 737101 tctttggtcc tgaatgaaaa gtgaatactt ttcggcactg gttcatgtcc atatatatag 737161 accaattcaa aagcagtaat acttgaaaat aacaccgaaa aataaaaatt taaatagtag 737221 acacgtttaa tgacttaaaa actaactttt tcatatctaa tattgtaaaa tgggcggaaa 737281 aagcttaaga atatgttatt ttacaaatca gagcgctgac acatatagag agctatatga 737341 tatgagtgag agcaactctc ccgtatatgc taagaatatt gtcgcttatt aggattgaaa 737401 gataggatca atgaggaata aatgttaccc ttttttctta aaaatgtaag aggaaattat 737461 gaaatatact ctgatttgtt tattattgat taagaacaat ataataaccg ctctggtagc 737521 tactgtacat ataatttgac ggcatatatt gctcatatat aaaactaccg cattacttcc 737581 agttgataga tttttaactc agtttcagta ctgccagaac tgctcattcg agattttttc 737641 tatttttaga ataggtaaaa ttgcacttaa atgtataagg gatgtacgaa gtgagtgccc 737701 agactgttac tatgacaatt aaactaatgt cgatgaccat ttgtttcgac aactccatct 737761 tcattttctt cacgcgccat actcggatga gaaagaatct tttctctaac tatacatttc 737821 caaacgcaat gatcaagaag aaagctaaat gttactttga gttcaattac tgagacatgt 737881 catgggaata tgaggaagaa acaaatctac gtgtattata ctccgtaaca tgtagagtaa 737941 ataccatagt tacctattta cctgtgtcga taaatgttca ttagctcata agtgatggga 738001 tacattgcta ttcctctgca atggaagctt cgatatctcc cttggggtcg ttatgagaga 738061 cgtctttagg gggggttttg acaacaaacg gatctacttt cgtcgatttg aactttcttg 738121 cagaaactcc aagtttaaat aactcattta tttccacgaa agtctttccg gcagtttctg 738181 gtaggtcaac cacagcccag attaaagtac aaaagcataa gacaccccag aaaaagcctg 738241 acttagcgcc ccagttccac ttcttagagt tcagttggta taagatgaga acgctacata 738301 tgatactgac cacattataa gtgttacgtg ctagaatgat tgttttcgtt cttagtcttg 738361 aagatggcat ttcagagact aggcaaaaaa cgaccggggc aattcctaaa ttgtaaaaaa 738421 atgctacagc cattaaaaga gaaccacttc ccattttgga accgtgcgta cttgagcacc 738481 ccaaaccgcc aataatgaaa aaaacaatgg tttggaaggc tagtccaaaa gcgtaaaggt 738541 catatctacc aaaatacttt gacgcccacc aagatagaaa tgtagcacaa ataccgagac 738601 agtattgaat aatactaaaa gtgaaggaca tttcagtact aacgccagcc ttttcgtaaa 738661 agtaagttga ataacctatt agtattgaac cacaagtggc ttgaccagcc cagcagagac 738721 aagtaattct cgttcttctt cgattaatct tgtcttcaaa acaatcacta taggagcctt 738781 ctttacttgt gagtctcttt tccttatcta tagtcacttt tattttgtcc acctccagag 738841 ttactagtat ttctttttca ggtcccttgc cgcttaaagt tcttctaagt gatctccttg 738901 cctcatcaaa ccttcctttt ttaactagcc accatggaga ttcaggtgca aaaaaaattc 738961 ccagtgctaa aggaactggc aaaatccact gtagggcaaa tggtagttta tatcctaatt 739021 ctgaatccgc atattttttt tgagaatttt tcatgattcc agctgcaaaa agttgtccaa 739081 ataaccagca caagtttgaa taggttgtaa ggtaatatct cagagccaat gggcatattt 739141 cagaagcgta agacaccgtc aaacactgaa aacaacccca tggcatcccg cacaatgctt 739201 gtcccacagc aatcatgcct aaactattgc aaaagtacag tataaaagtg aaggcagcta 739261 aaaaaaacaa tgcaataatc aatgtgtaac gatttccaac aagatccacg gagggccccg 739321 ttagctgtag ccccacaatt tcacctgcca tataacataa ggtcagcccg atttgccatg 739381 acgctgaaat ttcccattct ccagttttgt cattttgtga gccaaacttt ctctgaaaaa 739441 taggcaaggc gtagaaagct ccaagaatag ctgtgtcgta cccttccatg attaaagttg 739501 tagagaccaa tagtgaccaa gctgctgcct tgggatatgt attcaatgct gtcgcaagtg 739561 gcattcctct ttcactttcg tctgcctcct tggcatcctc agtagcgtca aatatctctg 739621 ttattacttt attgctatcg cttggcgctc ttgtatccgg actgaactca acatgaacaa 739681 tatctaagcc gtccttctta gtttgatcat ccatttctat ccagctgggt tcatgcgact 739741 tagcctttcc tgggtataca ttcgagtcac ttgtattttc ctttcttctg tttatgagaa 739801 aagataagtt tttcatagct aggtaatggc tttacaagac ctgtatctct atttgtgtta 739861 gattttgtga tggtaatctt tgcataataa ttccaagaac aggcctctaa gaattacaaa 739921 caacgattac agatgacccc accttttttt tatattctat agtcaacact atcatgaact 739981 tgtggcatac tcattgcata tggctgacag gatgtcaaat gctcccttct acgaaagatt 740041 ctgtgcacgt aaaacgcggg gtgtggaatg tcgcgatgac tctcgagcag agaaaaagac 740101 aaacatataa cgagctgatt cctctccaga agaacaaagc caacattgat tcaaactgag 740161 gacttaatat gattgactct ctggaaactg caacagtgtg attatagatc agaaattcat 740221 gctgtaattt tagtatatcg acctgtcgcg atgttgcaag cgtgacagat ctatacatat 740281 ttcgctaaaa ctgtcggtaa aataccaaca cgctgcactg cagaccacag attcgaaccg 740341 aagcatattt tcagaaattt acgagaggtc tttatagtca ccaaaatatc caaattgagt 740401 aattagaaag aaaaaaacac acatactgta gtccacaacc tgtttacgga caggttctgg 740461 ctgatgggat aaccactcta cctgactgct ctcctacttc atatttacct cccgaacaac 740521 gtgaaatctt tttgcttgga gaaaaacaag taaaaagtat aaatggagat gaaagatcca 740581 ccaataaatt ccagcttgat ttttcaacat atgatgacaa atgtgagtgc taaatctaag 740641 tcgtaagaca aataagaact tttaccataa tcagtatcct gggaaaagtg gtagaactac 740701 agtttatcaa gcttacccac aaagcattaa atatgctccc acaataacct ctggagtgat 740761 ataacaggta tgactttcaa gttatagtat attaaagatc ttggaattgg gcggtttagg 740821 cttgttcatt tcaaagctcg agtaagattt tagtatactt ttccctatag aaatatttcc 740881 gacatagatt ttttaatata agcacttctt ccatgacatt ttgtttcagt tatctctctt 740941 tcgtcgctac ttgagaaaac tatatggttg tacgaaaaag aaatggccaa aatattcttt 741001 gggccttatt aatctcatta ctattgtaag agttggccct taattttata gaaacactgt 741061 tttaaggcca aaaaaaaaag atgccaaaca tagaaaggaa atgtcgcttt acttggctaa 741121 ttggctctaa atcacaggtc ttaatactcg aaacgccatt gatgtactgt gcacaatttc 741181 cattccgggt taattataaa gatatcagcg tttattttca tccatggcaa tgaaaattgt 741241 aaaataatca tcatcaaaat ttgatatggt tgcaatagag ggaatgattt gatttttatg 741301 agacttatac gcatcaccct gtatttttgc aattacggcg atttataaaa cttataacgg 741361 aatttaagag tttcatccta ccaagcgtaa tcatagatat aaaaattcta ttgtgcaact 741421 catatttgtc attgaaacag ggacttttct ccgaagttta atatctagta tgagctatac 741481 accttaacca ctccttactt gtaaaggtac gaaaaagttg tcgttttagc gcgcacttac 741541 tgatggatgc tgaatcagta tagtgtttga ctgcggcagt aaactactca cagtagcagg 741601 cacgtactat ggaagttgtt tcgaggcgca tgataggaaa aagggtacca aaaaggatta 741661 gaagagaaaa ttttcataat gggaagtcac tgacgagggt tggtggttat ccgttttaaa 741721 aaaatattat gcaatcaagc tacaacatcc tgtaaatttt gtagtagaaa acttctatta 741781 taacggtttc tgaattggca tataaaatag tcaaaaggtg atctttaaat caacggtaaa 741841 aacagtgaag ctggtcctgt tgtagaatcg ccatttcctt tgtggtgata ggtctttaag 741901 taaagtaatg gtgaatttag ttaatttgtt aaccaacgcg actccagcta actgagcgca 741961 tggtctaata cagttccgtt agaaacatat tttcattttg atgaggtatc agtatttggc 742021 gactattatt tgaatgcatc tgtaatctgg atgaatgaaa ccttttatga aaccagaatt 742081 gtcccagcta ttatcaatgt ccgtgaatgg cttgaccata tggaggcaaa cgatccttca 742141 cctagtgtaa ctaacccact cgaaacttca attattatgc cttttcaacg gtagctcccg 742201 ctttaatgga ggatatgaaa gtagcataaa tgaattagaa aagtgtattc actgttctgg 742261 aatatacatg gtacgcaaga gatataaaaa tttataataa acgtacgtta tgcccgaagt 742321 gtatcccgaa ctacgggtta aactaaagct ttttaattac tagtaggttg gaggtttacc 742381 aatatgcgtt cttctttagg ccttacatta ctgaaacaat actggaaaat cactcttatg 742441 atgcttttaa gttatcacat ttaactttat ggcatggcct ccgtttgagc gcacggaaag 742501 attttatagt actttagtat gactattcgt tagcattgct ttatggtcgt actcggagta 742561 agaatatttt gtgagtgagc tggtaagatg aggatattgt agaatagcat ttttgctctt 742621 atgtgtattc ctggtatgat atataacatt tgtgcagctt cttactgatg aatagcatat 742681 ttcctgttta agagaggtag tagtgattaa ttagtaatat tagtattact gcatgataaa 742741 tcgcttgata aaagtgtcca ctcgcctttt aaagtcactc aatagagtgt agtattcata 742801 tctaacagaa tgcaaaagta tgaattttta agtccagaag ggcgttctca tttcttcatt 742861 aaagactctt cattgcggga caattgcgct tctttaatat atggccatag ttccacattc 742921 aatggtaaaa gccacataga tttctttgca gatagaaggc ggtagaagaa gtggctaaaa 742981 aaccattcac agtcaatccc ctcgaagaaa aactcttcat tcttccaggc ttttttctca 743041 aacaagtacc tattcatttt ccttgcaatt tcgtcccatc cattcgcacc actttcttgc 743101 tcatttataa tagtcaacaa gaattgcatc ttgtgttcca ttttcacgag taaagcagtc 743161 gtcctcatat tttggaaaag ccacaccatc atgaggaaaa acaatccagg acacaatata 743221 cgaaatgcaa ggcaaaaatg ctgtgacacg cagatacagt tcaaaaaagc aagccataat 743281 ggtagagagt aaatagtgaa aatccgcttt aaaaaccaag taagcttgga ccgatgaata 743341 tccttgggaa gctgaacgtc ttccaggcca acagggctcc atgatttttc agtattaaac 743401 aacttccatt gtttttcaac ttctctaaaa taaactccca atgcttcttc aatgtaaggg 743461 acggaatcct taaatgactt aaccttggca gcttcgtctt ttttcaaaga gaagggttcg 743521 agaagggttg ttctgaacgc ttcttggcag cccatggcat tgaagaaaaa gtacctagta 743581 ttccaagcct tattttcata taagtacgaa tttagatttg ctgcaacaac ttcccaatca 743641 tgaggatcag aacttggtgt gttttcagta acctctttgc aaaactgaat gagttgtttc 743701 gataaggaac gcttacgaga aagtccacaa ataacaagga caaatattgg tcccagaaac 743761 aggaccagaa gtgaaactat aagtgggtaa atacaattgt tggaaagttt ccaccagacg 743821 ctaagtggta gccataatag catccagatc ggaaacgcta aggacttgta aatttcataa 743881 caaaaccagg taaagctgct tctgaaaaga tcttgaggta gaacaatctt ttgggattcg 743941 agctgtttga aggataatac atctacactc ttctcatttt taagttcatt ctctttcatt 744001 ttcggtagtg agatggcagt tcgaggggtt ttttattcga gatagtaact tctgactttt 744061 cgcttttata cagcacagca gaaaaaaaaa gccgccgagg cgcgcgcgtt catgcaatgg 744121 ctcagtaacc tcgtgataga aaaagggcaa caatattggg ctattttagg caaagaaact 744181 cagctattcg aaaagggcat ccatttcatt tccggttttc tatctagcca actcgataat 744241 cgtaataacg aatttacaaa actttaatgc gggtacatca cggtgtgccg taactttggt 744301 ttacatttaa ggtgcgacca gcaatgtcac tgctcgtaca gcggttaccg cttgaatgaa 744361 atacatattt taagcgtaga tttcctgtga caaaactgtg taaacatcta gtagaaaata 744421 gacgtagctg tcacaaatat ttacacagga aagagtctgt cctacgtatc tgacatgaag 744481 attcatagaa ccaagttact tcccaatgtg gacaaccttt cgataccatg tcaatagctt 744541 ccccttatgt tcggtgtcac tgtaaaacgg atcaaaacaa aacctagagg tacggtggta 744601 ctcagatcat gcatgacctc tgggtaatta gcacttctcc cgcttgtttt gagattctgt 744661 atataaatat tgcaaacaaa aggatagagc gcggatggca gcccttacag taaaaattat 744721 tcgttttaat catgcgtcag tgtgagattc tatgacaata gtatgagaag atggggtgaa 744781 gtaaaagcgt ctgtatgact atagagtaca gttatattac aatatatgga atagagcata 744841 gtggtatgac gatattaagg aactttaagt taatgatacc atgatagtat taagacgcaa 744901 ttaagtgtgt ttatgtatta tggttgaaga atagaatatt tttatgttta ggtgatttta 744961 gtggtgattt ttttgtaata ttggcataag tgtatataaa ttgagtggtt agtatacggt 745021 gtaaaagtgg tataacgtat gtattaagag cagttataca atatttgggg ccgccgaatg 745081 agatatagat attaaaatgt ggataatcgt gggagttatg ggtaaatggc acagggtata 745141 gaccgctgag gcaagtgccg tgcataatga tgcgagtgca tttggtactg atggtgagag 745201 atgggtgatg gagtggaatg tgagagtagg gtaagtttga gagtggtata tactgtagca 745261 tccgtgtgca tatgccatat cagtatacaa gtgcaagtga gtatggcatg tggtggtggg 745321 attagagtgg tagggtaagt atatgtgtat tatttacgat tatttgttaa cgtttcaata 745381 tggagggtag aacaacagta cagtgagtag gacatggtgg atggtagggt aatagtaggg 745441 taatggtagt ggagttggat atgggtaatt ggagggtaac ggttatggtg gacggtggat 745501 ggtagtagta agtagagaga tggatggtgg ttgggagtgg tataatgaaa tgggacaggg 745561 taacgagtgg ggaggtaggg taatggaggg tacgttaaga gacaggttta tcagggttgg 745621 attagaatag ggttagggta gtgttagggt agtgttaggg tagtgtggtg tggtgtgtgg 745681 gtgtgggtgt gggtgtgtgt gtgggtgtgg tgtgtgggtg tggtgtgtgg gtgtggtgtg 745741 tgtgtgggtg t //