LOCUS BC013594 2607 bp mRNA linear ROD 03-OCT-2003 DEFINITION Mus musculus solute carrier organic anion transporter family, member 1a5, mRNA (cDNA clone MGC:6720 IMAGE:3586426), complete cds. ACCESSION BC013594 VERSION BC013594.1 KEYWORDS MGC. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 2607) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 2607) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (04-SEP-2001) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: Gilbert Smith, Ph.D. cDNA Library Preparation: Life Technologies, Inc. cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Baylor College of Medicine Human Genome Sequencing Center Center code: BCM-HGSC Web site: http://www.hgsc.bcm.tmc.edu/cdna/ Contact: amg@bcm.tmc.edu Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H., Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati, A.N., Gibbs, R.A. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 10 Row: a Column: 2 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 18699999. FEATURES Location/Qualifiers source 1..2607 /organism="Mus musculus" /mol_type="mRNA" /strain="FVB/N" /db_xref="taxon:10090" /clone="MGC:6720 IMAGE:3586426" /tissue_type="Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy." /clone_lib="NCI_CGAP_Mam1" /lab_host="DH10B" /note="Vector: pCMV-SPORT6" gene 1..2607 /gene="Slco1a5" /gene_synonym="Oatp3" /db_xref="GeneID:108096" /db_xref="MGI:MGI:1351865" CDS 139..2151 /gene="Slco1a5" /gene_synonym="Oatp3" /codon_start=1 /product="Slco1a5 protein" /protein_id="AAH13594.1" /db_xref="GeneID:108096" /db_xref="MGI:MGI:1351865" /translation="MGETEKRIATHGVRCFSKIKMFLLALTCAYVSKSLSGIYMNSML TQIERQFDIPTSIVGLINGSFEIGNLLLIILVSYFGTKLHRPIMIGIGCVIMGLGCFL MSLPHFLMGRYEYETTISPTSNLSSNSFLCMENRTQTLKPTQDPAECVKEMKSLMWIY VLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGILESGKMIGPIVGLLLGSFCA RIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLPKEGLQ DNVARTENDKEEKHREKAKEENRGITKDFLPFMKSLSCNPIYMLLILTSVLQINAFIN MFTFLPKYLEQQYGKSTSEVVLLIGVCNLPPICIGYLLIGFIMKKFRITVKKAAYMAF CLSLFEYLLSYFHFMISCDNFQVAGLTTSYEGVQHPLYVENKVLADCNTRCSCLTNTW DPVCGDNGLSYMSACLAGCEKSVGMGTHMVFQNCSCIQSSGNSSAVLGLCKKGPECAN KLQYFLIMSVIGSFIYSITAIPGYMVLLRCIKSEEKSLGIGLHAFCTRIFAGIPAPIY FGALIDRTCLHWGTLKCGEPGACRIYNINNFRRIYLVLPAALRGSSYLPAFFILILMR KFQLPGEMYSSETELADMKQTVKKSECTDVHGIPKVENDGELKTKL" misc_feature 253..1362 /gene="Slco1a5" /gene_synonym="Oatp3" /note="OATP_C; Region: Organic Anion Transporter Polypeptide (OATP) family, C-terminus. This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family aligns residues towards the C-terminus. The family OATP_N aligns residues from similar proteins towards the N-terminus. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described as belonging to the SLC21 family of transporters" /db_xref="CDD:pfam03137" misc_feature 1600..2088 /gene="Slco1a5" /gene_synonym="Oatp3" /note="OATP_N; Region: Organic Anion Transporter Polypeptide (OATP) family, N-terminus. This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family aligns residues towards the N-terminus. The family OATP_C aligns residues from similar proteins towards the C-terminus. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described as belonging to the SLC21 family of transporters" /db_xref="CDD:pfam03132" BASE COUNT 779 a 543 c 553 g 732 t ORIGIN 1 atttgctgct gtgaatttct ttttccgtca ccagcgagaa caccattttc taaagcttct 61 tcatgtatgt acttctcatt tggccaagtg gtaagactgt ttaaagaata gtcatttgga 121 gacaatcaga agaacaacat gggagaaaca gagaaaagga ttgcaaccca tggggtcaga 181 tgcttttcta agatcaagat gtttctgttg gcattaacat gtgcatatgt atccaaatca 241 ctctcaggaa tttatatgaa ttccatgctt acacaaatag agagacaatt tgatatcccc 301 acatctatag ttggacttat caatgggagc tttgagattg gaaatctttt gttgattata 361 ctcgtgagtt actttggaac aaaattgcac agacccatca tgattggtat tggatgtgtg 421 attatgggcc tagggtgttt cttaatgtcc ttacctcatt tcctcatggg ccgatacgaa 481 tatgaaacaa cgatttcacc tacaagcaac ttgtcctcaa acagcttctt gtgtatggaa 541 aacagaacac agaccttaaa gccaacgcaa gaccctgcag agtgtgtgaa agaaatgaaa 601 tcattaatgt ggatatatgt actggtagga aacatcatac gtggaattgg tgaaactccc 661 atcatgccct tgggtatttc ctacatagaa gattttgcca aatctgaaaa ctctccttta 721 tatattggga ttttagaatc aggaaagatg attggcccga ttgttggact tttgttggga 781 tccttctgtg caagaattta tgtagacaca gggtctgtga atacagatga cctgaccata 841 actcccactg atacacgctg ggtcggtgct tggtggattg gctttttggt ctgtgcagga 901 gtgaatatcc tgaccagcat cccctttttc ttctttccaa aaacactccc aaaggaagga 961 ttacaggata atgtggctag aactgaaaat gacaaagagg agaagcacag agaaaaagcc 1021 aaggaggaaa accgaggaat cactaaagat ttcctgccat tcatgaagag cctctcctgc 1081 aatcctattt acatgcttct catcctgaca agcgtgctcc agataaacgc atttatcaat 1141 atgtttacct tcttgcccaa atacctggag cagcagtatg gaaaatccac ttcagaggtc 1201 gtcctcctca taggtgtttg taacttacct ccaatctgca ttggatattt acttattggc 1261 tttattatga agaagttcag gattactgtc aagaaggctg catacatggc attctgccta 1321 tccctgtttg agtaccttct gtcttacttt cactttatga taagctgtga taatttccaa 1381 gttgctggct taactacctc ttatgaagga gttcagcacc ctctatatgt ggagaacaag 1441 gtccttgctg actgcaacac aaggtgtagc tgcttaacaa acacatggga tccagtgtgt 1501 ggagacaatg gcctatcata catgtcagcc tgccttgcgg gctgtgagaa gtctgttgga 1561 atgggaaccc acatggtgtt tcaaaattgc agctgcattc agtcatcagg aaactcatct 1621 gcagtcctgg ggctgtgtaa aaaaggccct gagtgtgcta acaagctgca gtacttttta 1681 atcatgtcgg taattggcag tttcatctat tcgatcacag ccatacctgg gtacatggtt 1741 cttctgaggt gtatcaagtc tgaagagaag tcacttggaa ttggattaca cgcattttgc 1801 acaagaatat ttgctggcat ccctgcaccc atttactttg gagctttgat agacagaacc 1861 tgcttacatt ggggaactct gaaatgtggt gagccaggag catgtaggat atacaatata 1921 aataacttca ggcgcattta tctagtgttg cctgcagcac taagaggatc aagctatctc 1981 cctgcattct tcattctaat acttatgagg aaattccagc tccctgggga aatgtactct 2041 tcagaaactg aacttgcaga catgaagcaa acagtgaaga aaagcgagtg cacagatgtg 2101 cacggaattc ctaaggtcga gaatgatgga gaactgaaaa ctaagctgta atgaatggca 2161 atggaaacct gctggcctgt gcaaggctct gaacagaatg cacattgcac ttcctttgaa 2221 tcatgagagg tacgagagaa ctcctttcct aaaataaatc agggctggac acagtgtaag 2281 atattctcaa aagtcaccgt ctcatcctca ggaggcctct ggtgctcact cattctagtc 2341 acatatccca gagcacagtg ctactttcaa aatcatctta aagtaaaacc tttgaagagg 2401 ggccacctaa atggcccaat ggaaaggtgt gctttctacc aaggctgaca aggtgtgttt 2461 gatccttggg accaacatgg cagaaggaca gaaccaacct cgctttcagg ttgtcctttt 2521 ctctctactc ccgcactgtg gtgtgcatat cccaccccaa acaaacaaac aaataaaaaa 2581 atttagaaac taaaaaaaaa aaaaaaa //